Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EEN-Innovate Plus Portugal (EEN-Innovate Plus PT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Portugal,Portugal,Portugal,Portugal,Portugal,Portugal,Portugal
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 143689.59
EU funding (EUR): 143689.59
Participants: 11
Project status: CLOSED

The proposal presented by this consortium, IAPMEI (coordinator) , ANI; CEC and INESC TEC, is based on the continuity of the work that has been provided within the framework of the EEN-Innovate PT proposal, in the biennium 2017/2018, and whose objectives remain and are intended to continue. It should be noted that during 2019, the H2020 program is still under way, and this year's focus will be to continue reinforcing the objectives proposed and achieved in the previous proposal and to initiate new approaches to the challenges posed by the EIC - European Innovation Council - which the EEN- Innovate Plus PT now aims to incorporate into this framework. Considering the challenges of the EIC, there will be new competition schedules to consider, from FTI - Fast Track Innovation and FET - Future and Emerging Technologies (one of three complementary lines of action to address different methodologies and scales, FET OPEN), which will require more expertise to accompany companies benefiting from this programs, as each addresses the needs of a particular community in the innovation ecosystem. Despite the time frame (one year), the challenges posed will require new approaches to the team, and therefore the reinforcement of stakeholders and partners (e.g. Clusters, Financial Institutions, etc.) - creating greater synergies and converting the Network into a "hub and spoke". The main goal of this project is to contribute to reach a greater economic impact from SMEs innovation activities, by reinforcing their innovation management capacity and contributing to establish more effective and efficient links between actors through all the innovation chain (hub and spoke model .In sum, we intend to provide services to 74 companies - Partner 1-IAPMEI – 16 services, (KAM/FTI/FTE-8, EIMC 8) Partner 3-ANI – 17 services(KAM/FTE/FTE 6 + EIMC 11), Partner 10-CEC-20 services, Partner 11-INESCTEC 21services.

Keywords: innovation,innovate,innovative,management,smes,portugal,sme instrument,scaleup,eimc
How MHC-I editing complexes shape the hierarchical immune response (EditMHC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2181250.0
EU funding (EUR): 2181250.0
Participants: 1
Project status: SIGNED

Our body constantly encounters pathogens or malignant transformation. Consequently, the adaptive immune system is in place to eliminate infected or cancerous cells. Specific immune reactions are triggered by selected peptide epitopes presented on major histocompatibility complex class I (MHC-I) molecules, which are scanned by cytotoxic T lymphocytes. Intracellular transport, loading, and editing of antigenic peptides onto MHC-I are coordinated by a highly dynamic multisubunit peptide-loading complex (PLC) in the ER membrane. This multitasking machinery orchestrates the translocation of proteasomal degradation products into the ER as well as the loading and proofreading of MHC-I molecules. Sampling of myriads of different peptide/MHC-I allomorphs requires a precisely coordinated quality control network in a single macromolecular assembly, including the transporter associated with antigen processing TAP1/2, the MHC-I heterodimer, the oxidoreductase ERp57, and the ER chaperones tapasin and calreticulin. Proofreading by MHC-I editing complexes guarantees that only very stable peptide/MHC-I complexes are released to the cell surface. This proposal aims to gain a holistic understanding of the PLC and MHC-I proofreading complexes, which are essential for cellular immunity. We strive to elucidate the mechanistic basis of the antigen translocation complex TAP as well as the MHC-I chaperone complexes within the PLC. This high-risk/high-gain project will define the inner working of the PLC, which constitutes the central machinery of immune surveillance in health and diseases. The results will provide detailed insights into the architecture and dynamics of the PLC and will ultimately pave the way for unraveling general principles of intracellular membrane-embedded multiprotein assemblies in the human body. Furthermore, we will deliver a detailed understanding of mechanisms at work in viral immune evasion.

Keywords: membrane proteins,macromolecular complexes,er quality control,membrane transporters,fluorescence labeling,chemical biology,super resolution microscopy
Wanderlust is the passion for discovering (Wanderlust)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-05-18
End date: 2021-01-17
Duration (months): 8.0
Total project cost (EUR): 133012.5
EU funding (EUR): 60000.0
Participants: 1
Project status: CLOSED

Wanderlust is the name of the European Researchers Night in Zaragoza. This year 2020 it will celebrate the 11th edition. Wanderlust is a concept that includes the core values of research: the excitement of discovering, exploring, researching and the emotion of sharing this stimulating work with society. Wanderlust is the largest scientific festival in Spain and consists of a true festival of culture that combines different kinds of activities and performances to get all audiences, from 3 to 99 years old. Both the event and the program of activities are designed to value and disseminate the figure and valuable work of our researchers. In order to get this goal, we carry out synergies and innovative experiences that combine research with other cultural disciplines. The success of the project is based on the experience of the organizing team. Esciencia is a company specialized in science outreach with more than 13 years of experience and with a multidisciplinary team of 30 employees. We have been the organizers in the past 10 editions. We have the “know-how” to make this event a success of participants and impact scope, as well as satisfaction of the visitors. We use a proved methodology whose strengths are: the event's communication campaign, communication advice and training in didactic and communication tools to researchers to set up their performances, and the evaluation procces that allows us to enforce the suggestions of the public and to improve the event. As a result of this experience we have a network of stakeholders, sponsors, researchers and suppliers that guarantee the achievement of th objectives. Our event has become a national reference. We have created a powerful network of contacts and collaborate with several projects. In this edition we improve our rates of participation and impact and we will reach 375,000 people with the promotional campaign and 10,000 direct participants in the event.

Keywords: outreach,general public,caixaforum zaragoza,education,science fair,hands on,geocaching,game,teatre,edutainment,mscfellows,show,humorous mologues,music
Why do individuals cooperate? Exploring the behavioural, cognitive, and hormonal mechanisms governing cooperation in macaques. (CooPMacaque)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

A myriad of species including humans are social. Maintenance of sociality is based on cooperative interactions among individuals. Regardless of theories and empirical explanations, experimental evidence scarcity has rendered addressing the evolution of cooperation challenging. Ergo, little is known about what influences humans and other animals to cooperate and select specific partners during cooperative interactions. Proximate mechanisms facilitating cooperation can provide crucial information on its evolution and maintenance. In this project, I will focus on the following proxies - personality, prosociality, dominance rank-relationships, and the interplay of hormones - to understand how cooperation evolved, using ~100 individuals belonging to 5 macaque species (Macaca mulatta, M. fuscata, M. fasicularis, M. sylvanus, and M. silenus). I will examine - how similarities in personality and dominance-rank relationships influence partner choice; whether prosocial motivations of individuals initiate and enhance cooperative interaction; and the effect of the interplay of peripheral oxytocin, testosterone, and cortisol on cooperation. The innovative and new perspectives of the project include– a. avoiding anonymous/forced dyad testing - testing of macaques based on their intrinsic motivations to cooperate, thus, prioritising areas of ecological relevance such as partner choice; b. testing macaques in their social groups; c. testing in semi free-ranging environment. Hence, I will use an integrative, interdisciplinary, and comparative approach in the project. My existing expertise in social cognition and subsequent training during the fellowship will undoubtedly result in pioneering research output and scientific advancement in the area of cooperation dynamics. This project is the first attempt to study cooperation from an unexplored angle and will provide us with significant information on why cooperation evolved and how it is being maintained in social systems.

Keywords: animal cognition,non human primates,cooperation,animal behaviour,partner choice,macaques,social cognition
Women In Research and higher EDucation (WIRED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Over the last years, women have made a significant progress in academia and science across all Europe. Yet, their representation across scientific fields and ranks remains uneven, as they are still under-represented in some STEM disciplines (science technology engineering and mathematics) and in senior positions. The WIRED project – Women In Research and higher EDucation – aims at investigating gender inequalities in academia by focusing on the reasons why and the mechanisms through which women are at disadvantage in the career progression and/or they drop-out from the academic labour market. It will undertake this challenge by means of an innovative, comparative, inter-disciplinary, multi-model and multi-level research. WIRED draws its originality from its unique data, which are the result of the combination of observational longitudinal micro-data on the Swiss and Italian academic populations with experimental data on gender discrimination in the selection processes. The observational field will be based on different administrative and web-based data sources, including the micro data on academics held by the Italian Ministry of Education, University and Research and by the Swiss Federal Statistical Office, where the fieldwork will be undertaken. The experimental research is based on a vignette survey which will be submitted to a sample of professors in targeted Italian and Swiss Universities, chosen on the base of the results of the first part of the research. The combination of these two methods within a comparative approach will provide an extremely rich and comprehensive understanding of gender differences in academic career trajectories allowing to simultaneously shed light on the micro, meso and macro levels of explanation. Face to the scarcity of comparative and longitudinal insights, WIRED will represent a tremendous step forward in the debate on women in academia and science.

Keywords: gender inequalities,gender and academia,women in the stem,longitudinal data,experimental methods
Differential Higgs distributions as a unique window to New Physics at the LHC (HiggspT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 1317500.0
EU funding (EUR): 1317500.0
Participants: 1
Project status: CLOSED

In 2012, the ATLAS and CMS experiments at the Large Hadron Collider at CERN announced a ground-breaking discovery: both experiments observed a new particle. Subsequent measurements confirmed it to be a Higgs boson. In the Standard Model (SM) of particle physics, which describes the known elementary particles and their interactions, as well as in many extensions of the SM, the Higgs boson is fundamentally linked to the question of how elementary particles acquire mass. A thorough program of measurements is necessary to determine if this particle has indeed the properties of a Higgs boson as predicted by the SM or one of its extensions, and to gain a complete understanding of the mass generation for elementary particles. Studies of the Higgs sector now open a unique window to the discovery of New Physics. The aim of the presented project is to perform a detailed analysis of the Higgs differential distributions measured in Higgs decays to diphotons and to four leptons, using the data collected by the ATLAS experiment between 2015 and 2021. These distributions are sensitive to effects from New Physics and will be confronted with precise theoretical predictions. In this way, the indirect extraction of Higgs couplings and the search for effects from new heavy particles can lead to a discovery of New Physics. The detailed analysis of differential distributions goes substantially beyond the standard analyses based on measured event counts. A dedicated program is needed to achieve these goals. With an ERC Starting Grant, I will assemble a team to make decisive contributions to these challenging measurements and build a unique research program. As a former leader of the ATLAS Higgs-to-diphoton physics group and current leader of the electron and photon reconstruction group I am in an ideal position to establish a strong research team. This team will build on the important contributions to the Higgs boson discovery and property studies made by my Young Investigators Group.

Keywords: higgs boson,new physics,atlas
Clinical validation of prognostic biomarkers of chemotherapy response in liquid biopsies (SENSITIVITYMARKERS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Netherlands
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The lack of clinically validated biomarkers to properly select patients for treatment with anti-cancer agents remains a major problem. Patients are not always receiving the most optimal treatment, resulting in poor response rates and high societal costs. By profiling more than hundred drugs on a broad panel of genetically characterized cell lines, researchers from NTRC have identified novel predictive drug response biomarkers for several anti-cancer agents. In the feasibility (Phase 1) study two of these genomic drug sensitivity markers will be validated using whole genome sequencing data of patients treated with the corresponding agents. In addition, a protein kinase that is involved in glucocorticoid resistance in T-cell leukemia will be validated. Proliferation assays will be carried out with blood samples from leukemia patients using proprietary inhibitors that NTRC has developed against this kinase. After successful completion of Phase 1, the project will be extended to other drug sensitivity markers identified by cancer cell line profiling in Phase 2 of the project. In addition, assays to determine the mutant status of cancer genes in circulating DNA and miniaturized proliferation assays with patient blood cells will be developed. In the commercialization phase of the project, novel clinically validated biomarkers and assays for several anti-cancer drugs will be licensed to pharmaceutical and diagnostic companies. The results of the feasibility project will increase the value of NTRC’s biomarker discovery platform, resulting in a doubling of turn-over within two years. In addition, novel IP will be generated and licensed to pharmaceutical and diagnostic companies. After six years an ROI of seven times the initial investment is estimated. Overall, the project will result in increased clinical availability of genomic biomarkers, contribute to an overall improvement of cancer therapy, and increased sustainability of health care systems in the EU.

Keywords: personalized therapy,anti cancer drugs,genomics,leukemia,kinases,cytostatics,kinase inhibitors,prednisone,cell lines
A Comprehensive Approach to School Choice and Education (CompSCHoice)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Spain,Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2020-12-31
Duration (months): 65.0
Total project cost (EUR): 1207500.0
EU funding (EUR): 872923.21
Participants: 2
Project status: CLOSED

School choice is one of the most hotly debated policies in education. Advocates argue that school choice allows equal access to high quality schooling for all. High-income families have always had more choice, either through residential choice or through enrolment in private schools. Therefore increased choice should also improve equity by allowing minority and low-income students to choose too. On the other hand, school choice critics suggest that school choice can increase sorting between schools based on their socio-economics status, suggesting high-income families benefit more from these policies. Three different and disconnected literatures in economics provide different and often contradicting answers to these questions. We propose a unified theoretical framework that merges these three literatures and allows for a comprehensive analysis on school choice design and its impact on actual choice, outcomes and segregation in schools and neighborhoods. Unique and newly constructed data sets are used to address novel empirical challenges. The data constructed for Barcelona shall become one of the largest and most comprehensive data sets not only on school choice but also on public education worldwide. Using the data set from Barcelona we 1) estimate families’ preferences and, for the first time, evaluate the efficiency of different mechanism through structural estimation of our model and counterfactual analysis. We then 2) evaluate the impact that peer effects have on parents' choice and on outcomes. Exploiting the occurrence of hurricane Katrina in New Orleans and the aid programs implemented we aim at 3) estimating the distribution of willingness to pay for quality schools for families with different socio-economics. And last we exploit a policy change in Catalunya in 2009 to 4) provide evidence on how increased flexibility of the school system to adapt for differential maturity levels affects individual short and medium-term outcomes.
Imaging Biomolecular Self-Assembly with a Molecular Photonic Scale (PHOTOMASS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2024-11-30
Duration (months): 66.0
Total project cost (EUR): 1999574.0
EU funding (EUR): 1999574.0
Participants: 1
Project status: SIGNED

We propose to transform our understanding of biomolecular interactions and self-assembly by directly visualising the associated molecular mechanisms. To achieve this, we will capitalise on our recent development of interferometric scattering mass spectrometry (iSCAMS), which enables not only the detection and imaging of single biomolecules in solution, but also the accurate determination of their molecular mass at the single molecule level. These studies, and the development of the associated technology, will bridge the gap between high-resolution structural and low-resolution solution-based methods for studies of biomolecular interactions and assembly. We will achieve these ambitious goals by pursuing five interconnected objectives chosen according to their potential to maximise scientific and societal impact by addressing fundamental questions related to biological function and health: (1) Determine the physicochemical origins of mono- and polydispersity; (2) Visualise the mechanism of viral capsid assembly; (3) Reveal the molecular basis of cytoskeletal dynamics; (4) Capture the aggregation and inhibition of amyloid aggregation. These four system-oriented objectives will be accompanied by a technological objective, (5) aimed at implementing improvements in terms of dynamic range and resolution of iSCAMS required for studying self-assembly. As a consequence of the universal applicability of our approach for characterising molecular interactions, oligomeric distributions and dynamics in a facile fashion in solution, this ambitious project opens up a broad range of exciting applications beyond molecular biophysics in fields as drug-discovery, bioanalytical and biomedical science.

Keywords: biophysical chemistry,label free imaging and sensing