Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genetically Encoded Multicolor Reporter Systems For Multiplexed MRI (GeneREFORM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-04-30
Duration (months): 60.0
Total project cost (EUR): 1478284.0
EU funding (EUR): 1478284.0
Participants: 1
Project status: CLOSED

In order to fully understand the complexity of biological processes that are reflected by simultaneous occurrences of intra and inter-cellular events, multiplexed imaging platforms are needed. Fluorescent reporter genes, with their “multicolor” imaging capabilities, have revolutionized science and their founders have been awarded the Nobel Prize. Nevertheless, the light signal source of these reporters, which restricts their use in deep tissues and in large animals (and potentially in humans), calls for alternatives. Reporter genes for MRI, although in their infancy, showed several exceptionalities, including the ability to longitudinal study the same subject with unlimited tissue penetration and to coregister information from reporter gene expression with high-resolution anatomical images. Inspired by the multicolor capabilities of optical reporter genes, this proposal aims to develop, optimize, and implement genetically engineered reporter systems for MRI with artificial “multicolor” characteristics. Capitalizing on (i) the Chemical Exchange Saturation Transfer (CEST)-MRI contrast mechanism that allows the use of small bioorganic molecules as MRI sensors, (ii) the frequency encoding, color-like features of CEST, and on (iii) enzyme engineering procedures that allow the optimization of enzymatic activity for a desired substrate, a “multicolor” genetically encoded MRI reporter system is proposed. By (a) synthesizing libraries of non-natural nucleosides (“reporter probes”) to generate artificially “colored” CEST contrast, and (b) performing directed evolution of deoxyribonucleoside kinase (dNK) enzymes (“reporter genes”) to phosphorylate those nucleosides, the “multicolor” genetically encoded MRI “reporter system” will be created. The orthogonally of the obtained pairs of substrate (CEST sensor)/ enzyme (mutant dNK) will allow their simultaneous use as a genetically encoded reporter system for in vivo “multicolor” monitoring of reporter gene expression with MRI.

Keywords: chemical exchange saturation transfer cest mri,molecular and cellular imaging,mri reporter genes,mri of gene expression
New Electro Spraying Process of Two-Component, Solvent-Free, Fast-Curing, Liquid Resins (KEMISTATIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: France
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-03-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Powder coating is the leading coating method, as it forms a high-resistance layer, without the need of a solvent to keep the binder and filler parts in a liquid suspension form. However, polymers used for the epoxy powder coating contain Bisphenol A which can have serious adverse health effects. Moreover, the aesthetic value is low due to peel off or pinhole phenomenon and the range of applications and the substrate size are limited, as the substrate needs to follow a heating curing process (at 180-200oC). Thus, the coating industry is in need of a technology, able to be applied on a wide range of materials, providing enhanced aesthetic potential, at a cost and energy-efficient way. KEMICA COATINGS is an expert on the field of polyurethane and poly (urea-urethane)-based high performance resins. Since 1992, we have spent more than €2M on R&D to find an innovative solution to face those challenges; KEMISTATIC process is a pioneering, sustainable coating technology, consisted of a new generation of ''green'', two-component, liquid resins to be applied through an innovative electrostatic spraying method, without the need to heat the substrate. Our new resins are completely solvent and Bisphenol A free. We create a coating technology of low initial investment (€150,000), able to save up to 150m3/h of gas emissions. Moreover, it can be applied on any size and type of material, including wood, EPS, electrical equipment, etc. In addition, it has a strong aesthetic aspect, as it provides an endless finishing variety. The overall aim of KEMISTATIC is to commercialize a new sustainable coating process with enhanced technical and application opportunities, replacing the conventional powder and liquid paint coating systems. With this project, KEMICA COATINGS aims to reach revenues of about €33 million after the fifth year of commercialization, and create at least 113 new job positions. With a Phase 2 investment of €2.8M, this would imply a Return of Investment of 3.39.

Keywords: coatings,electrostatic spraying,green solvent free resins
Assessment of African Vegetation Resources: New Perspectives from Satellite Passive Microwave Datasets (AfriVeg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

Livelihoods of most of the African population strongly depend on local ecosystem services, such as grazing, agriculture, firewood, and construction timber. Although an overall greening trend is shown by both dynamic global vegetation models (DGVMs) and Earth Observation (EO), large uncertainties for each data source are reported and significant divergence between outputs have been documented, impeding accurate assessment of vegetation dynamics in Africa. The overall purpose of this project is to develop methods to for an improved assessment of African vegetation resources based on new capabilities originating from satellite passive microwave observations. Specifically, the vegetation optical depth (VOD) derived from passive microwave data is sensitive to the water content in both the green and woody (i.e., branches and stems) vegetation components which is different from the traditional optical-infrared greenness driven vegetation index (VI) being primarily sensitive to chlorophyll abundance. By combining multi-frequency VOD retrievals with long-term VI datasets, in situ measurements, and DGVMs, this project will accurately quantify woody biomass, green biomass, net primary production (NPP), vegetation phenology and ecosystem functional types (EFT) in Africa, as well as their long-term changes and the climate and socio-economic drivers. The results are expected to pave the road for improved vegetation resource management in Africa and understanding of global carbon cycling. To achieve this, I will be trained in cutting edge skills (EO time series, flux measurements and ecosystem modeling). My major mobility activity will be sparking the integration of passive microwave VOD, carbon and water flux measurements and DGVMs for an improved understanding of changes in vegetation resources and drivers hereof in Africa.

Keywords: africa,passive microwave,biomass,phenology,ndvi,vegetation
Aerosol, Clouds and Trace Gases Research Infrastructure Implementation Project (ACTRIS IMP)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Spain,Spain,Estonia,Ireland,Spain,Austria,Germany,Germany,Spain,Italy,Cyprus,Switzerland,Finland,Poland,Sweden,Switzerland,Norway,Belgium,Bulgaria,Greece,Greece,Greece,Romania,France,France,France,France,France,France,France,Czechia,Netherlands,Netherlands,Denmark,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 4999997.5
EU funding (EUR): 4999997.5
Participants: 51
Project status: SIGNED

The Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS) is a pan-European research infrastructure producing high-quality data and information on short-lived atmospheric constituents and on the processes leading to the variability of these constituents in natural and controlled atmospheres. Different atmospheric processes are increasingly in the focus of many societal and environmental challenges, such as air quality, health, sustainability and climate change. ACTRIS brings essential information for understanding atmospheric processes and bio-geochemical interactions between the atmosphere and ecosystems. ACTRIS is composed of Observational and Exploratory Platforms, Topical Centres, Data Centre, and Head Office that is coordinating the ACTRIS activities. ACTRIS serves a vast community of users such as scientists, policy makers, private sector, funding organisations and educators. ACTRIS activity started almost 20 years ago, and currently more than 100 European partners from 22 countries are engaged in building the research infrastructure. ACTRIS was selected to the ESFRI roadmap in 2016 and was granted with EC preparatory phase project funding (ACTRIS PPP) for 2017-2019. Interim ACTRIS Council (IAC), representing the governmental representatives of 16 member countries and one observer country, have submitted the ACTRIS ERIC step 1 documents to EC in Feb 2019. IAC is aiming to establish ACTRIS ERIC in 2021. ACTRIS is entering the implementation phase in 2020. The ACTRIS implementation project, ACTRIS IMP, will take ACTRIS into a new level of maturity and will set the needed structures for the implementation actions, both at the national and European level. ACTRIS IMP builds on three main pillars: securing the long-term sustainability, implementing of ACTRIS functionalities, and positioning ACTRIS in the national, European and international science and innovation landscape. ACTRIS IMP will enable ACTRIS to respond to the users’ needs and requirements.

Keywords: actris,aerosol,clouds,trace gases,research infrastructure,esfri,atmospheric research,implementation,eric,catalogue of services,services to users,science,innovation
How dendritic mRNA and protein distributions shape synaptic plasticity (MolDynForSyn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany,Germany,Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1469625.0
EU funding (EUR): 1207285.16
Participants: 3
Project status: SIGNED

Proteins are the building blocks of life and neurons constantly need proteins to remain functional. This is a formidable challenge because neurons must regulate dendritic protein numbers across hundreds of micrometers, and need to redistribute proteins quickly in response to any synaptic changes. For example, long-term plasticity requires new proteins. Yet, it is still a puzzle how the available pool of proteins is redistributed via diffusion or active trafficking and how synaptic protein numbers are modified by increased translation of local mRNAs. Similarly, it is now an open question how the dysregulation of mRNA transport translates into plasticity impairments, how these modify circuit functions and ultimately lead to cognitive impairments. To answer these questions and connect the molecular dynamics to circuit function, we will develop a data-driven theory describing the dendritic mRNA and protein distributions in space and time and will use it to study the emergent synaptic plasticity dynamics in dendrites and its impact on memory storage. We will use data from leading experimental labs to identify how the unique combination of dendritic mRNAs, dendritic morphology, and synaptic activity gives rise to the synaptic protein dynamics that shapes circuit function. Our theory framework will generate and test hypotheses about how individual components such as mRNA motion, translation or degradation shape the protein exchange between synapses and clarify how they translate into multi-synapse synaptic plasticity rules that give rise to memory formation, memory generalization and separation. The unique combination of theory and experimental data will improve our understanding of long-term memory mechanisms and numerous neurological diseases that are associated with neuronal trafficking pathologies or protein synthesis dysfunction.

Keywords: neural circuits,protein dynamics,synaptic dynamics,neural network models,computational neuroscience
Metal Organic Framework mediated synthesis for novel catalysts in the Fischer Tropsch synthesis. (PyroMOF2cat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Hydrocarbons are the most widely used chemicals and fuels, and are quite accurately, the driving force of occidental social well-being. The major part of hydrocarbons on Earth is found in crude oil. The depletion of the latter while demand for it is increasing, and the geopolitical risk related, boost the use of different hydrocarbon sources. The Fischer Tropsch synthesis (FTS) from ‘syngas’ comprises the exothermic synthesis and WGS reactions to obtain gasoline fraction (C5-C12), hydrocarbons (paraffins and olefins) and oxygenates in a wide range of boiling points, from methane to waxes. Transition metals are typically used in FTS process due to their considerable activity, cobalt being the preferred one due to its higher activity for FTS, selectivity toward linear products, stability, low activity towards water-gas shift (WGS) reaction and low price. Recently, Metal Organic Frameworks (MOFs) have emerged as promising precursors for the synthesis of nanomaterials, due to their unique structure, atomic metal dispersion and textural properties. The goal of this proposal is to design, to control and to apply the MOF mediated synthesis to obtain outstanding cobalt based catalysts for the Fischer Tropsch synthesis, and to set the ground of this potentially universal method for the synthesis of metal supported catalysts. The project will be carried out at Delft University of Technology (TU Delft) within the Catalysis Engineering (CE) section of the Chemical Engineering department (ChemE) and in close collaboration with industry. The resulting catalysts are expected to possess unique catalytic properties by virtue of their controlled synthesis, leading to the preparation of paramount catalysts which will be studied for the first time in the FTS.

Keywords: mof mediated synthesis,fischer tropsch synthesis,novel catalysts,kinetic modelling,industrial application
BioResorbable Ostheosynthesis Implant (BriScrew)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Austria
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the EU, 20 % of all hospital treated injuries are bone fractures. If surgical treatment of bone fractures is necessary, it is currently performed with standard metal implants. Conventional gold-standard titanium or steel implants are too stiff, have adverse effects on the patient (feeling of pain during temperature changes) and lead to stress-shielding. Their usage is associated to the risk of infections and bone loss. Often a secondary surgery for removal is needed which is associated with almost 50 % higher healthcare costs. When Mg-based implants are used they are frequently alloyed with rare earth elements, aluminium, silver or zirconium. However, zirconium reduces the healing properties, aluminium and rare earth elements may remain in the organism and can lead to unpredictable effects, while the application of silver might result in a silver-disease. Within the BRI.SCREW project we will introduce to the market revolutionary osteosynthesis implants that do not need surgical removal. We will use our own bioresorbable magnesium alloy which consists merely out of extremely high purified natural materials including Mg, Ca and Zn. BRI.SCREW is 100 % biodegradable, stimulates the healing process of the bone and has no side effects due to the implant's composition. Our orthopaedic implants will prevent the need of a second operation to remove the implant and will therefore minimize patient costs and surgical risks. Our team consists of highly qualified individuals with experience in medicine, engineering and quality assurance. The investment in BRI.SCREW will pay off. We have estimated that after 5 years from launch, we will sell in total 81.900 BRI.SCREWs (sales €13.2M), hire 10 technical employees, and manage 5% of the global market. We will earn €8.7M profit and generate a ROI of 3.95 by commercializing this technology. We foresee the payback time in 2 years after commercialization (in Q3 of 2020).

Keywords: ostheosynthesis,bone generation,implant,biodegradable screw,orthopaedic,treatment,bone fractures,patented,magnesium alloy,dissolve,surgery avoidance
Demand Response in Block of Buildings (DR-BOB)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Italy,Italy,Romania,France,France,France,Netherlands,United Kingdom,United Kingdom
Call: Demand response in blocks of buildings (H2020-EE-2015-2-RIA, 2015)
Start date: 2016-03-01
End date: 2019-08-31
Duration (months): 42.0
Total project cost (EUR): 5136769.5
EU funding (EUR): 4274499.5
Participants: 10
Project status: CLOSED

The aim of the DR-BOB project is to demonstrate the economic and environmental benefits of demand response in blocks of buildings for the different key actors required to bring it to market. To achieve its aim the DR-BOB project will: • Integrate existing technologies to form the DR-BOB Demand Response Energy Management solution for blocks-of-buildings with a potential ROI of 5 years or less. • Demonstrate the DR-BOB integrated solution at 4 sites operating under different energy market and climatic conditions in the UK, France, Italy and Romania with blocks-of-buildings covering a total of 274,665 m2, a total of 47,600 occupants over a period of at least 12 months. • Realise up to 11% saving in energy demand, up to 35% saving in electricity demand and a 30% reduction in the difference between peak power demand and minimum night time demand for building owners and facilities managers at the demonstration. • Provide and validate a method of assessing at least 3 levels of technology readiness (1-no capability, 2-some capability, 3-full capability) related to the technologies required for consumers’ facilities managers, buildings and the local energy infrastructure to participate in the Demand Response Energy Management solution at any given site. • Identify revenue sources with at least a 5% profit margin to underpin business models for each of the different types of stakeholders required to bring demand response in the blocks-of-buildings to market in different local and national contexts. • Engage with at least 2,000 companies involved in the supply chain for demand response in blocks of buildings across the EU to disseminate the projects goals and findings.

Keywords: demand response measures
A New Monitor for Cosmic Rays in the Solar System: Inverse-Compton Emission from Cosmic-Ray Electrons Scattering with Sunlight (SolarIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

How well do we understand charged particle propagation in the solar system? This is an important topic for both astrophysics and space weather. Unfortunately, we still lack a fully predictive theory to this problem; a major challenge to this is the lack of cosmic-ray (CR) measurement throughout the solar system, as most data are measured locally on Earth. I propose to overcome this hurdle in my SolarIC project by using the solar inverse-Compton (IC) emission—produced by CR electrons scattering with Sunlight—as a remote probe for CR distribution throughout the solar system. I will achieve this through three main results. First, I will detect and analyze the solar IC emission with Fermi-LAT data to study its morphology and time dependence. Second, I will calculate the theoretical prediction of the solar IC emission for both GeV and MeV regimes, utilizing state-of-the-art CR simulations. This will be a theoretical foundation for interpreting the data. And for the first time, I will compute the polarization signatures of solar IC emission. Third, building on the previous two results, I will constrain and test contemporary models of CR propagation in the solar system through cross correlation of the Fermi-LAT data with the theory prediction. I will also perform a mock tomographic analysis of the solar IC emission, utilizing the polarization signature. This will be an important and novel prediction for the proposed future MeV space gamma-ray telescopes, such as e-ASTROGAM. Through my SolarIC project, I will demonstrate that solar IC emission can be used to provide valuable data and constraints on CR distribution in the solar system. This will be an important step leading to a better understanding of charged-particle propagation in the solar system, which will have significant impacts on many astrophysics disciplines including solar physics, cosmic-ray physics, neutrino astrophysics, and dark matter searches.

Keywords: gamma rays,cosmic rays,solar modulation,dark matter,neutrinos