Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High-throughput droplet-based single-cell small RNA sequencing technology (droplet-small-seq)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Lithuania
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-11-29
Duration (months): 24.0
Total project cost (EUR): 146112.0
EU funding (EUR): 146112.0
Participants: 1
Project status: SIGNED

Droplet-based single-cell RNA-sequencing (scRNA-seq) technologies have penetrated almost all branches of life sciences and have significantly advanced our understanding of cellular processes and organism development. However, despite their astonishing impact, most of the scRNA-seq technologies reported to date rely on poly(A) tail capture and thus are mainly restricted to the protein-coding RNAs, while neglecting a substantial proportion of the transcriptome, including small non-coding RNAs. As a result, very little is known about the non-coding RNA expression and function in individual cells, and especially their role in the establishment of cellular phenotypic diversity. Small RNAs contain a variety of classes, of which miRNAs are the most common and these act as regulatory molecules by suppressing translation of mRNAs. In addition, loss-of-function studies of miRNAs uncovered their involvement in development of nearly all tissues, including hematopoiesis. However, most studies exploring miRNA dynamics reported to date relied on bulk cell assays, thus disregarding the individual cell types and their heterogeneity. In the scope of this proposal, we aim to develop a high-throughput droplet-based single-cell small RNA-seq (droplet-small-seq) for simultaneous miRNA and mRNA capture and sequencing. We will apply this newly developed technique to investigate the regulatory roles of miRNAs in cell fate decision during hematopoietic development at a single-cell level.

Keywords: mirna,microfluidics,scrna seq,droplet small seq
Human Skin Microbiome Engineering (HuSME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The skin microbiome constitutes an attractive platform to incorporate novel functionalities to the host, due to accessible location, tight contact with the host, low immunogenicity, and easier genetic manipulation, among other reasons. I will adopt a translational synthetic biology approach to engineer the human skin commensal C. acnes (formerly P. acnes) as a disease-sensing biological device (“biodevice”) with therapeutic activity. Precisely, engineered C. acnes will detect atopic dermatitis (AD, the most common chronic inflammatory disease worldwide) and respond by producing an anti-inflammatory molecule. First, I will develop a vector and a methodology for efficient gene delivery into C. acnes. Next, I will construct synthetic gene circuits that will allow C. acnes to detect inflammatory markers in vitro and to respond by secreting anti-inflammatory signals. Finally, I will use the C. acnes biodevice as an in vivo therapeutic product: I will apply the engineered bacteria on a mouse model of AD and evaluate its potential as a therapeutic tool capable of disease-sensing and regulated maintenance of skin homeostasis. This project will contribute to the emerging field of human microbiome genetic engineering, will inspire and guide future efforts towards microbiome repurposing for therapeutics, and has the potential to provide exploitable results and better therapeutic options for AD patients.

Keywords: translational synthetic biology,smart engineered bacteria,programmable probiotics,human skin microbiome engineering,skin microbiome,c acnes,p acnes,gene circuit,atopic dermatitis
Sodium-Ion and sodium Metal BAtteries for efficient and sustainable next-generation energy storage (SIMBA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Ukraine,Germany,Sweden,Norway,Norway,Slovakia,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Next-generation batteries for stationary energy storage (H2020-LC-BAT-2020, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 7914350.0
EU funding (EUR): 7914349.5
Participants: 16
Project status: SIGNED

The project main goal is the development of a highly cost-effective, safe, all-solid-state-battery with sodium as mobile ionic charge carrier for stationary energy storage applications. To achieve this goal, several aspects need to be considered including material innovations, sustainable electrode and cell manufacturing, improved characterisation and understanding of the electrochemical processes. SIMBA has the ambitious and realistic goal to tackle these challenges and has formulated the following objectives: (1) Safer batteries with a novel Solid-State Electrolyte (SSE) (TRL3-5), by developing a new class of single-ion conducting polymers (SIPEs) and its production method. (2) Higher energy density and more durable anodes by developing materials up to TRL5 using sustainable manufacturing methods. (3) Low-cost and higher energy cathode materials, by developing ultra-low-cost Prussian White (PW) and high energy density layered oxides (P2/O3) up to TRL5. (4) Obtaining deep understanding of fundamental mechanisms incl. degradation phenomena, taking place at the Solid-Electrolyte-Interface (SEI) and within the battery components. (5) Demonstration of a scaled-up highly efficient 12V, 1Ah battery module incl. BMS to validate the re-use of materials, recyclability, performance, LCA, and potential for further development. Jointly this will result in a sodium-based battery demonstrating the improved performance, recyclability and sustainability, for a stationary energy storage use-case, including a detailed Total Cost of Ownership analysis.

Keywords: sodium battery,solid state electrolyte,stationary storage,lower cost,longer lifetime,improved safety,efficient recycling
A novel multi-functional nanocomposites against Parkinson’s disease for the protection and regeneration of dopamine neurons with anti alpha-Synuclein aggregation properties. (NEUROCURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-09-16
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 1
Project status: SIGNED

Parkinson’s disease (PD) is the second most common neurodegenerative disorder that is characterised by progressive loss of dopamine neurons and abnormal intra-neuronal accumulation of protein α-synuclein (αS). None of the available treatments have shown ability to slow down the progression of the neurodegeneration. One of the therapeutically potent approaches to combat PD is neurotrophic factor (NTF)-based therapies. Delivery of NTFs to the brain shows a notable therapeutic potential due to the ability to stop and reverse neurodegeneration in animal models. The most potent NTFs for PD therapy so far are CDNF and GDNF that have been recently studied in clinical trials on PD patients. Despite of the promising results, CDNF and GDNF does not pass through the blood brain barrier (BBB) and should be delivered to the brain through a risky microsurgery. Thus, there is a great need for an effective method that can deliver CDNF/GDNF through the BBB avoiding intracranial surgery. Another promising strategy for curing PD is based on αS clearance and control of its pathological aggregation and propagation. Our preliminary results showed that beta-casein coated AuNPs have great capacity to reduce αS aggregation and can be used to deliver NTFs to the brain. This proposal combines nanomedicine and molecular neurobiology to develop multi-functional AuNP-based medicine against PD that will positively impact the disease progression through mitigation of the parthenogenesis associated with αS and support the survival of dopamine neurons by CDNF/GDNF delivery to the brain. The applicant will get training needed for his future independent research career through hands-on training in the top scientific laboratories and by managing the highly innovative research at the interface of different disciplines connecting two excellent scientists: Prof. Saarma, a world leading molecular neurobiologist and Prof. Teesalu, an expert in homing peptides.

Keywords: parkinson s disease,nanoparticles,drug delivery,cerebral dopamine neurotrophic factor cdnf,glial cell derived neurotrophic factor gdnf,blood brain barrier,neuroregeneration
Euler systems and the conjectures of Birch and Swinnerton-Dyer, Bloch and Kato (BSD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 1428588.0
EU funding (EUR): 1428588.0
Participants: 1
Project status: CLOSED

In order to celebrate mathematics in the new millennium, the Clay Mathematics Institute established seven $1.000.000 Prize Problems. One of these is the conjecture of Birch and Swinnerton-Dyer (BSD), widely open since the 1960's. The main object of this proposal is developing innovative and unconventional strategies for proving groundbreaking results towards the resolution of this problem and their generalizations by Bloch and Kato (BK). Breakthroughs on BSD were achieved by Coates-Wiles, Gross, Zagier and Kolyvagin, and Kato. Since then, there have been nearly no new ideas on how to tackle BSD. Only very recently, three independent revolutionary approaches have seen the light: the works of (1) the Fields medalist Bhargava, (2) Skinner and Urban, and (3) myself and my collaborators. In spite of that, our knowledge of BSD is rather poor. In my proposal I suggest innovating strategies for approaching new horizons in BSD and BK that I aim to develop with the team of PhD and postdoctoral researchers that the CoG may allow me to consolidate. The results I plan to prove represent a departure from the achievements obtained with my coauthors during the past years: I. BSD over totally real number fields. I plan to prove new ground-breaking instances of BSD in rank 0 for elliptic curves over totally real number fields, generalizing the theorem of Kato (by providing a new proof) and covering many new scenarios that have never been considered before. II. BSD in rank r=2. Most of the literature on BSD applies when r=0 or 1. I expect to prove p-adic versions of the theorems of Gross-Zagier and Kolyvagin in rank 2. III. Darmon's 2000 conjecture on Stark-Heegner points. I plan to prove Darmon’s striking conjecture announced at the ICM2000 by recasting it in terms of special values of p-adic L-functions.

Keywords: arithmetic algebraic geometry
Computer-Aided Fashion with Yarn-Level Fabric Models (FabricMetrics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 149545.0
EU funding (EUR): 149545.0
Participants: 1
Project status: CLOSED

The Animetrics ERC Starting Grant has led to the invention of the first computer models capable of simulating in an accurate, efficient and robust manner the behavior of full textiles using a yarn-level representation. The proposed models handle frictional yarn interactions at the small scale, yet they naturally produce the rich large-scale nonlinearity of textiles. In contrast, models used in the fashion, engineering, or VFX industries nowadays, describe textiles as a continuum, and do not reach the accuracy required for validating the mechanical behavior and visual appearance of cloth. The FabricMetrics project will develop a commercial prototype that will leverage yarn-level fabric models, and will enable digital testing of designs, utilize economic and renewable materials while achieving desired mechanical properties, or explore the design space of textiles until the desired fit, drape and flow are achieved. The project plan includes the development of the commercial prototype, testing phases, establishment of connections and alliances with potential customers (fashion schools and fashion companies), and the refinement of the current business plan.

Keywords: cloth design,textile simulation
Innovative High Resolution Electro-Static printing of Multifunctional Materials. (Hi-Response)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Developing next generation nanomaterials, nanodevices and nanosystems
Action type: Innovation actions
Countries involved: Austria,Spain,Spain,Israel,Austria,Germany,Belgium,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: High-definition printing of multifunctional materials (H2020-NMP-PILOTS-2014, 2014)
Start date: 2015-03-01
End date: 2018-12-31
Duration (months): 46.0
Total project cost (EUR): 7601984.21
EU funding (EUR): 6281339.83
Participants: 14
Project status: CLOSED

The EU is well placed to exploit printed electronic technologies to create greater economic and social benefits for the EU, but only if we are able to commercialise innovative technologies created within the EU. Ink jet printing technologies are at the forefront of printed electronic developments. However, Ink jet printing has only been able to achieve a resolution of >=10um and the viscosity of printable inks is limited to <40 centipoise, this further limits the solids content of inks to <30-Vol% and the size of the nano-fillers to <50nm typically. These factors limit the range of functional inks that can be printed as well as the resolution and final properties of the resultant printed/sintered structures and components. The HI-RESPONSE project is based on highly innovative, patented Electro-static printing technology (ESJET) that has already been proven on TRL 4 to print to a resolution of 1um and be able to print inks with a viscosity of up to 40.000 cP. The resultant printed/sintered structures will therefore be able to achieve a high resolution and increase final component properties through enabling the printing of highly filled nano-inks and functional organic materials. This technology will be further developed to TRL 6 within the project to allow for the design and assembly of a multi-head system that can achieve resolution, speeds and cost that far surpassed that of current ink-jet systems. The resultant system will be demonstrated at TRL 6 for a wide range of materials, including: nano-Cu and nano-ceramic filled inks and organic polymers. Each of these materials will be printed to create components specifically defined and specified by the industrial organisations within the consortium: Infineon, Ficosa, Piher (Meggitt) and Zytronic. The specific end-user defined applications are: Automotive aerials and sensors, metal meshed for OLED and touch screens, conductive through silicon vias and mechanical strengthening ribs for thin Si-wafers.

Keywords: high resolution,printed electronics,ink formulation,oleds,automotive,semi conductors,touch screens,inspection and repair
Integrating Diversity in the European Union (InDivEU)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Estonia,Italy,Switzerland,Türkiye,Finland,Croatia,Lithuania,Poland,Slovakia,Slovenia,Belgium,Sweden,Latvia,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Liechtenstein
Call: Past, present and future of differentiation in European governance (H2020-SC6-GOVERNANCE-2018, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 3132250.5
EU funding (EUR): 3000000.0
Participants: 27
Project status: CLOSED

The challenge of Integrating Diversity in the European Union, InDivEU, is back on the EU agenda as it strives to forge a post-crisis future, respond to Brexit and reach out to European citizens. Europe’s Union has been under assault from populist political entrepreneurs who have mobilized distrust of and opposition to the EU. Hence the urgency of building the next phase on solid foundations. Differentiated integration (DI) is a compelling issue in deliberations on the Future of Europe. InDivEU has built a consortium of some of Europe’s premier research universities and outstanding scholars of DI to address the challenges facing the EU and commits to supplying robust evidence to support policy. The aim of InDivEU is to create a comprehensive knowledge base on DI of relevance to Europe’s policy makers. This work will have a direct impact on the work of AFCO in the EP, the Commission planning unit, prime ministers offices, European Affairs Committees and numerous civil society nodes. InDivEU will: 1. produce a comprehensive reappraisal and re-assessment of DI; 2. develop and test a range of models and scenarios, based on a catalogue of design principles, for the future use of DI; 3. create a DI Manual to support policy makers in designing future DI solutions; 4. evaluate existing policy proposals for DI and draft proposals for DI and other forms of flexibility as an input into the European debate based on four InDivEU unique data sets, tool kit and scenarios. The project’s foundations are built by establishing the normative criteria for a fair system of DI and by critically analysing the constitutional and institutional architecture of DI. InDivEU will complete two unique data bases, EUDIFF 1 & 2, on the uses of DI and two data sets on public opinion and flexible implementation. This is complemented by zooming in on key policy fields and on EU relations with its neighbours. InDivEU includes thorough analysis of the DI preferences of citizens, parties and governments.

Keywords: eu integration process,eu policy making,modes of multilevel governance,policy advice,political science
EMpowerment through liquid Integration of Migrant Youth in vulnerable conditions (MIMY)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Belgium,Norway,Hungary,Poland,Romania,Sweden,United Kingdom,United Kingdom,Luxembourg
Call: Social and economic effects of migration in Europe and integration policies (H2020-SC6-MIGRATION-2019, 2019)
Start date: 2020-02-01
End date: 2023-01-31
Duration (months): 36.0
Total project cost (EUR): 2999998.75
EU funding (EUR): 2999998.75
Participants: 15
Project status: SIGNED

MIMY is a comparative interdisciplinary study of migrant integration with the aim of empowering young migrants in vulnerable conditions and supporting integration strategies within the EU. The project brings together 11 disciplines and 12 partners to examine the dynamic, open-ended process of integration at the EU, national and local level by examining 18 case studies within 9 countries. MIMY analyzes integration policies and strategies across macro (EU migration policies), meso (regional economic & social systems) and micro (individual practices) levels by establishing a unified theoretical framework at the intersection of liquid integration, resilience and vulnerability. The innovative, multi-method approach (e.g. policy analyses, quantitative data analysis, delphi study and participatory action research) provides in-depth analyses of: 1) the long-term socio-economic effects of successful and failed integration; 2) factors fostering or hindering integration processes of young migrants (considering the heterogeneity and diverse biographical backgrounds); and 3) how diverse social actors and institutions can support the agency of young migrants by further strengthening their resilience and resistance strategies. In contrast to existing approaches, MIMY emphasizes and combines the vertical (multi-level governance structure) and horizontal (sector policies) axes. MIMY will show which integration strategies and policies can successfully support the empowerment of young vulnerable migrants to become active citizens within an inclusive society by working in close cooperation with migrants as peer researchers. It will contribute extensively to integration studies - empirically, methodologically and conceptually - through its place- and gender-sensitive and migrant-centred approach. MIMY offers direct benefits to young migrants and evidence-based policy-recommendations will help to push policy and practice innovation in the field of migrant youth integration in Europe.

Keywords: youth,integration,local level,vulnerability,resilience,embeddedness,empowerment,micro level,meso level,macro level,mixed methods
Cost effective solution against insects in long-term grain storage by natural diatomaceous earth (PestiSi)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Hungary
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-02-28
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The European Union targets to reduce the application of chemical pesticides, however due to the climate change and increased transportation, the problems related to pest invasions are increasing. We have developed a natural insecticide that can be applied during long-term grain storage based on formulated diatomaceous earth. Our product can kill all insects during storage with a long-lasting effect that is completely harmless to humans and other mammals. Our objective is to commercialise our diatomaceous earth as insecticide material during storage, to develop the commercialisation strategy (including pricing) and distribution channels in Europe as well as to scale-up and standardise our production. In this Phase 1 project we aim to carry out a feasibility study to confirm our preliminary business assumptions. The success of this project will promote the growth of our company.

Keywords: pest managament,diatomaceous earth,insecticide