Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Novel Exploration Toolkit for Finding Geothermal Heat Efficiently and Sustainably (FindHeat)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Netherlands,United Kingdom,France,Spain,Czechia,Iceland,Germany,Switzerland
Call: Advanced exploration technologies for geothermal resources in a wide range of geological settings (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 2955616.25
EU funding (EUR): 2955616.25
Participants: 11
Project status: SIGNED

Geothermal energy can provide a climate-friendly baseload for heat and power that is independent from wind and sun. However, the growth of geothermal energy lags behind EU targets. This is because geothermal energy projects have comparatively high technical and economic risks, which impacts public support negatively and holds back investment. Reliable exploration strategies that have inherently lower economic and technical risks and hence increase public support are key to drastically reducing these barriers. FindHeat develops a novel, conceptual model-based geothermal exploration workflow. A modular toolkit, the FindHeat platform, provides innovative software tools and geophysical exploration techniques at significantly lower costs than the state-of-the-art. The platform will be validated across eight geologically diverse geothermal plays to demonstrate its economic and technical benefits arising from faster turnaround times for exploration and appraisal of geothermal resources, making better use of legacy data and non-invasive geophysical techniques, and constraining uncertainties with respect to the size of the heat source and the range of possible heat production rates. The FindHeat exploration approach enables geologically-based resource assessments and will lead to a paradigm shift towards exploiting geothermal resources with inherently low technical and economic risks, thus improving exploration success and economic feasibility. Comprehensive social science research at the use cases will help to earn the public trust that the FindHeat approach will lead to a more efficient and sustainable exploitation of geothermal energy. FindHeat brings together extensive expertise and innovation from industry and academia, covering geology, geophysics, engineering, social science, economics, communication, and technical training. The industry partners of the consortium are direct end users of the FindHeat platform and will exploit the results in their daily operations.

Keywords: geothermal exploration geological uncertainty reservoir modelling geophysics techno economic analysis
Developing novel inhaled bioengineered Extracellular Vesicle RNA based advanced therapeutics, delivered by tailored aerosol delivery technology for the treatment of lung cancer (INSPIRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Ireland,France,Germany,Portugal
Call: Next generation advanced therapies to treat highly prevalent and high burden diseases with unmet medical needs (HORIZON-HLTH-2021-TOOL-06, 2021)
Start date: 2022-06-01
End date: 2026-02-28
Duration (months): 45.0
Total project cost (EUR): 13269061.75
EU funding (EUR): 13268022.5
Participants: 9
Project status: SIGNED

Lung cancer (LC) treatments have advanced in recent years with the advent of genetic profiling and immunotherapy. However, LC is a complex heterogeneous disease and survival rates remain poor. RNA (mRNA, microRNA, other non-coding RNAs and nucleic acid based modulators of same) and gene therapies (DNA or gene editing) for delivering nucleic acid-based therapeutics have curative potential for a host of indications previously untreatable. They have yet to enter the mainstream, due to safety concerns and difficulties delivering them efficiently to areas other than the liver, kidney and circulatory system. Aerosol delivery allows direct targeting of lung tissues but viscous mucus in the lung is a significant barrier to gene transfer to the target cells of the lungs. Even if the mucus layer can be penetrated, inefficient penetration through the cell membrane further impedes access of these vectors to the underlying target cells, thus preventing successful gene transfer. Delivery is a major barrier to successful pulmonary gene therapy for competing viral and non-viral gene transfer vectors and the vast promise of gene therapy has many challenges to overcome. OMNI's novel solution is pioneering the use of genetically modified MSC EVs with a proprietary surface engineering technology to further enhance delivery through the mucus barrier and into the targeted lung cells. This platform technology also combines efficient aerosol delivery of the EVs via AERO's proprietary state of the art vibrating mesh nebulizer technology. This unique solution solves the problems associated with lung targeted delivery of RNA based advanced therapies.

Keywords: gene therapy,atmp,lung cancer,inhaled bioengineered extracellular vesicle aerosol delivery gmp manufacturing for in vivo screening screening optimisation single cell resolution study
RISC-V for Cloud Services (RISER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Greece,Spain,France,Germany,Switzerland
Call: Open source for cloud-based services (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5316125.0
EU funding (EUR): 5316125.0
Participants: 7
Project status: SIGNED

Building on top of outcomes from the EPI and EUPilot projects, RISER will develop the first all-European RISC-V cloud server infrastructure, significantly enhancing Europe's open strategic autonomy. RISER will leverage and validate open hardware high-speed interfaces combined with a fully-featured operating system environment and runtime system, enabling the integration of low-power components, including the RISC-V processor chips from EPI and EUPilot and LPDDR4 memories, in a novel energy-efficient cloud architecture. RISER brings together a set of 7 partners from industry and academia to jointly develop and validate open-source designs for standardized form-factor system platforms suitable for supporting cloud services. Specifically, RISER will build the following two cloud infrastructures: (1) An accelerator platform, which includes the ARM-based RHEA processor from EPI and a PCIe acceleration board that will be developed within the project which will integrate up-to four RISC-V based EPI and EUPilot chips. (2) A microserver platform, which interconnects up to ten microserver boards all developed by the project, each one supporting up to four RISC-V chips coupled with high-speed storage and networking. Embracing hyperconvergence, the microserver architecture will allow for distributed storage and memory to be used by any processor in the system with very low overhead. The open-source system board designs of RISER will also be accompanied by open-source low-level firmware and systems software, and a representative Linux-based software stack to support cloud services. To evaluate and demonstrate the capabilities of the RISER platforms we will develop three use cases: (a) Acceleration of compute workloads, (b) Networked object and key-value storage, and (c) Containerized execution as part of a provider-managed IaaS environment. RISER will offer open access to the microserver platform, facilitating uptake and enhancing the commercialization path of project results.

Keywords: risc v,open hardware interfaces,pcie accelerator board,microserver,boot firmware,linux operating system,open source software stack for cloud services
Mapping social disruptive effects of extractivism (MAPSOCEXTRACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Poland,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-11-30
Duration (months): 27.0
Total project cost (EUR): 155793.6
EU funding (EUR): 155793.6
Participants: 2
Project status: SIGNED

Erradicating poverty, reducing inequality and achieving decent work and economic growth for the least developed countries is a major challenge in the 21st century. In this context, the way we provide and manage natural resources necessary for our day-to-day – athmosphere, water, minerals, wind, vegetation, sunlight, land – plays a fundamental role, as the resources tend to be extracted through large-scale infrastructures and in middle and low income countries. Since 1970, extraction of fossil fuels (coal, oil and gas) has increased from 6bn tonnes to 15bn tonnes, metals have risen by 2.7% a year, and other minerals (particularly sand and gravel for concrete) have surged nearly fivefold from 9bn to 44bn tonnes. Overall, resources are being extracted from the planet three times faster than in 1970, even though the population has only doubled in that time (UN Global Resources Outlook 2019). This study aims to build evidence based theories around and for the better understanding of the so-called Resource Curse, i.e. the paradox that countries with an abundance of natural resources tend to be associated with lower growth rates, promotion of authoritarianism and worsening living standard. We will give a central place to the concept of social disruption, a term used in sociology to describe the alteration, dysfunction or breakdown of social life, often in a community setting. By bringing together Earth Observtion (EO) and secondary data analysis to the study of natural resources extracition in Colombia, we will provide evidences that the large-scale extraction of resources disrupt regional economies in a number of ways: increase in crime, poverty and inequality and the creation of an “economic dessert” in the surrounding of the extraction sites. The results are expected to challenge some of the existing regional development theories, whille highlighting the conditions under which extractivism can still drive sustainable development.

Keywords: extractivism,nighttime lights,remote sensing,inequality,poverty,crime
Energetics of quantum correlations (EQC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Argentina
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-09-30
Duration (months): 27.0
Total project cost (EUR): 164031.48
EU funding (EUR): 164031.48
Participants: 2
Project status: SIGNED

The proposed project Energetics of Quantum Correlations aims to establish a comprehensive framework for studying quantum correlations and thermodynamics in continuous variables. The key research goals established within this project encompass the creation of a universally applicable operational framework delineating the relationship between entanglement and energy manipulation. This framework should be readily employable within the quantum technology sector. Additionally, the project aims to conceive practical applications for harnessing energetic quantum advantages. Lastly, it seeks to formulate an experimental plan for assessing the proposed theory. To achieve these goals, the project leverages the expertise of both the hosting institution, Universidad de Buenos Aires (UBA), and the partner institution, ICFO. Furthermore, the project emphasises knowledge transfer and collaboration. During the outgoing phase, the researcher will collaborate closely with Prof. Paz's team at UBA, gaining insights into quantum thermodynamics and correlations. In the return phase at ICFO, collaboration with Prof. Acín's Quantum Information Theory group will involve advanced analytical and numerical methods for characterising quantum correlations. The project places a strong emphasis on skills transfer. The researcher will actively engage in co-supervising PhD and master's students, enhancing supervisory and management skills. Teaching activities at both institutions will improve pedagogical abilities, while participation in interdisciplinary initiatives will foster networking and knowledge exchange. In addition, the project is committed to develop energy efficient quantum technologies, aligning with the MSCA Green Charter. With a strong foundation in theory and practical experiments, coupled with a commitment to sustainability and knowledge exchange, it is well-positioned to make significant strides in our understanding of quantum correlations and their role in energy processing.

Keywords: continuous variables quantum information,quantum correlations,quantum thermodynamics
SInGle cells iN AuToimmUne inflammatoRy disEases (SIGNATURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,France,Belgium,Italy,Germany,Netherlands,Malta
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2859381.26
EU funding (EUR): 2630239.2
Participants: 16
Project status: SIGNED

Autoimmune disorders are highlyImmune-mediated disorders are highly heterogenenous entities for which the mechanisms of disease progression and therapeutic responses are only recently beginning to be understood. The patterns of transcriptome are the reflection of distinct cell types that are involved in the development of the disease process. Our plan is to approach the diseases beginning from a global view that allows us to then come down to the most relevant cell types in tissues and blood. In addition, by understanding disease heterogeneity and diseases similarities, we can also identify the best pathways to be targeted with specific biological treatments. The diseases involved are systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, asthma, chronic obstructive pulmonary disease, Crohn´s disease and ulcerative colitis. Based on a unique ongoing platform of clinical groups across Europe and specialists in cell and molecular profiling, imaging analyses, single cell sequencing and analysis, we will identify the molecular basis of each of the diseases heterogeneity, the mechanisms of treatment non responsiveness, and develop a specialized training program where students will be able to visualize the overall work from design to analysis of the data and become engaged in the unique multi-disciplinariry of this platform. The platform will have available existing clinical studies and clinical trials, but will be also producing new data from prospective studies where samples and tissues for each disease, based on the appropriate indications will be obtained with special protocols, for the study. The engaged students will be permeated by the latest advances in not one, but several new approaches and systems biology modelling, and develop out-of-the-box concepts where diseases can be viewed not as separate clinical entities but as novel groups of shared molecular and cellular patterns that impinge on specific tissues by specialized cell types.

Keywords: autoimmautoimmunity,asthma,systemic lupus erythematosus,rheumatoid arthritis,multiple sclerosis,crohn s disease,ulcerative colitis,chronic obstructive pulmonary disease,single cell analysis
Cold Sintering Process for Fabrication of Biodegradable Drug-Eluting Ceramics (DrugCer)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: SIGNED

DrugCer proposes a paradigm shift in drug delivery for bone restoration by making drugs an inherent part of a biodegradable ceramic implant. Such a new approach would require drug loading during ceramic sintering, which in turn requires multidisciplinary research and development of low-temperature/cold ceramic processing. Accordingly, the main research goal of DrugCer is to apply a novel pressure-assisted “Cold Sintering Process” (CSP) for co-sintering of biodegradable ceramics with drugs. To achieve the goal, the researcher will receive advanced training in CSP and develop the co-sintering process by establishing a relationship between the processing parameters and properties of the resulting bioceramics. She will train in and master cryo-focused ion beam milling and cryo-scanning transmission electron microscopy to investigate the process kinetics and densification mechanisms. Finally, she will train in and develop methods for complex shaping to adapt the method for potential translation to preclinical studies. Cold-sintering will decrease energy consumption in bioceramics’ fabrication. It will also enable bioceramic co-sintering with other temperature-sensitive materials (e.g., polymers), opening paths to innovations in fields beyond orthopedics or even medicine (e.g., construction ceramics). Multidisciplinary supervising teams at Fraunhofer IKTS (host) and Penn State University (secondment) will support training through research and transferrable skills development (grant writing, teaching/mentoring, project management, networking, and horizontal skills). Inter-sectoral communication with Charité hospital (short visits) will ensure high-quality guidance in developing prospective biomedical technology from its very beginning. Thus, DrugCer will equip the researcher with unique expertise, skills, and a professional network for establishing an independent group in the niche of low-temperature, energy-efficient ceramic processing.

Keywords: cold sintering process,drug loading,drug release,biodegradable,bone healing
The chemical exposome in pregnant women and metabolic dysregulations analysis towards the prioritization of hazardous chemicals (Expo-IS-omics)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 169326.72
EU funding (EUR): 169326.72
Participants: 1
Project status: TERMINATED

Expo-IS-omics is an interdisciplinary and highly innovative project in the field of human exposomics and bioinformatics. The main objective of EXPO-IS-OMICS is to obtain a holistic picture of both the external and internal chemical exposome in a large cohort of pregnant women to study which are the contaminants that can cause metabolic alterations. Once we know which contaminants are having more effects, we will develop new cheminformatics tools, capable to predict the chemicals with potential to dysregulate human metabolism based on in-silico predicted molecular predictors. EXPO-IS-OMICS will analyse samples of blood and urine of >200 pregnant women residents in Greece from the Rhea Cohort. This project will use state-of-the-art instrumentation to provide nontarget data at trace levels from a vast chemical domain, obtaining with the same data information of both contaminants’ presence (external chemical exposome) and specific alterations in the endogenous chemical profile (internal chemical exposome), by means of target, suspect, nontarget and metabolomics strategies. EXPO-IS-OMICS will also be pioneer in developing cheminformatics tools to predict when a certain chemical may represent a problem to human health. For the development of the tool, experimental data from this project will be joined with others cohort’s results in which the applicant is currently involver and the principal investigators have agreed to share (e.g. BISC (https://www.projectebisc.org/) and Insulin (https://www.tecnatox.cat/list-of-projects)) for validation purposes. The expert knowledge of fellow and host group gives the security to reach the ambitious objectives.

Keywords: human exposure,metabolomics,high resolution mass spectrometry
Religion and Comics: New Forms of Mediation of Religion (RELIGIOMICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 320924.16
EU funding (EUR): 320924.16
Participants: 3
Project status: TERMINATED

RELIGIOMICS aims at capturing new forms of religion and spirituality represented and experienced in comics by both artists and audiences. Considering the growth of comics production and consumption, this project is crucial to understand the transformations of religious phenomena in Western societies and their connections with popular culture. RELIGIOMICS investigates the relationship between comics and religion, by studying: 1) the artists’ subjectivities and biographical paths, 2) the intertwined influences between the artistic production and religion, 3) audiences’ receptions and 4) the transformation of the comics field. RELIGIOMICS proposes a cross-national comparative perspective focusing on artists and audiences, with different religious and cultural backgrounds in Europe and the USA. It is innovative in considering comics as a medium for religious expression and not only as an instrument of commodification and banalisation of religion. It is multidisciplinary as it combines and connects sociology of religion, comics studies, media studies, and sociology of art. The fellow will be hosted at the University of Lausanne (outgoing associated partner), the University of Harvard (secondment), and the University of Bologna (host institution). The fellow, an expert in sociology of religion, will gain the expertise to carry out the research: in Lausanne, on the relationship between contemporary art and religion, at Harvard, on comics studies and spirituality and pop culture, and in Bologna on sociology of art and discourse analysis. RELIGIOMICS will address the following questions: (RQ1) How do comics artists live and represent religion and spirituality? (RQ2) How does the comics medium shape, and how is it shaped by, religion and spirituality? (RQ3) How are religious narratives and symbols experienced by the audiences of comics? (RQ4) How did religion favour the emergence of the semi-autonomous artistic field of highbrow comics in tension with commercial comics?

Keywords: comics,popular culture,religion,spirituality,esotericism,graphic novels