Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Plastics Recycling from and for home appliances, toys and textile (PRecycling)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Greece,Denmark,Germany,Belgium,Türkiye,Spain,Netherlands,Cyprus,Norway
Call: Paving the way to an increased share of recycled plastics in added value products (RIA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-04-01
End date: 2026-03-31
Duration (months): 48.0
Total project cost (EUR): 6974419.5
EU funding (EUR): 6974419.0
Participants: 17
Project status: SIGNED

As it is addressed by the European Plastics Strategy (European Green Deal & Circular Economy Action Plan 2.0), new methods to reliably calculate, verify and report the recycled content in products need to be developed, boosting the increase of recycled content in everyday products against the use of virgin materials. However, measuring the recycled content is complex, requiring product tracing to the production source. PRecycling aims to develop an easy-to-use methodology for sorting, sampling, tracing and recycling plastic waste streams, including detection and separation of legacy additives, along with standard analysis procedures for both plastic waste materials and recyclates (secondary raw materials) in order to produce consistently high quality, safe-to-use recyclates based on their degradation degree and added-value products with predicted lifetime. Smart tracing via digital systems will be developed in parallel, to ensure the quality and safety of reused materials, targeting a sustainable, transparent and functional Circular Economy Model for the recycling market. The environmental and financial viability of PRecycling solutions will be assessed throughout life cycle and cost analysis in order to reach competitive prices of recycled products. The above will be demonstrated, producing (I) home appliances components, (II) toys/learning resources, and (III) 100% recycled textile, starting from the same sector recyclates and different European regions. However, the proposed methodology in PRecycling could be adapted by many other sectors, i.e. packaging, vehicles, and electric/electronic equipment, triggering significant societal impact apart from commercial and industrial interest. Demonstration activities will serve as part of a community awareness initiative, showing that 'from waste to product' transformation is scalable, replicable, traceable, commercially viable and most importantly, safe to use, both within the same and new supply chain products.

Keywords: plastic waste stream,recyclate,sorting,mapping,recycling,upcycling,polymer processing,manufacturing,digital tracing,blockchain tool,home appliances,toy industry,circular textiles
Realistic modeling of unconventional superconductors (RealSuper)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2131675.5
EU funding (EUR): 2131675.5
Participants: 1
Project status: SIGNED

Feynman diagrammatic extensions of dynamical mean-field theory are powerful enough for calculating unconventional superconductivity in actual materials. As a proof of principle, we were able to predict the superconducting phase diagram, the electronic and magnetic spectra of infinite-layer nickelates - with astonishing accuracy. At the same time, a new class of finite-layer nickelates, La_n+1Ni_nO_3n+1, was discovered last year. These Ruddlesden-Popper nickelates led to a boost of scientific activity and put common wisdom of superconductivity in nickelates and cuprates into question, as clearly multi Ni orbitals are relevant. Our objective is to (1) realistically model superconductivity in these finite-layer nickelates and in cuprates, to achieve a similarly good agreement with experiment as for infinite-layer nickelates, and to quantify the relative importance of spin and charge fluctuations. We will validate our calculations against a carefully selected variety of experiments: photoemission and optical spectroscopy, neutron and resonant inelastic x-ray scattering, the superconducting temperature Tc and gap, its doping and pressure dependence. If successful and achieving a consistent picture, we can settled the arguably biggest quest of solid state theory: the physical origin of high-Tc superconductivity. Already in the normal phase, we can (2) study exciting physics: pseudogaps, waterfalls, strange metal behavior, pi-tons, spin and charge density wave order. With an improved understanding of high-Tc superconductivity, a further aim is to (3) eventually predict how to optimize superconductivity in nickelates and cuprates and even to identify new classes of superconductors. Advancing our understanding and developing a predictive power is how theory can contribute to push Tc toward room temperature, which bears the prospects to revolutionize how we generate, transport and consume electric energy.

Keywords: unconventional superconductivity,strongly correlated electron systems,computational materials science,nickelates,cuprates
DIGITAL MAINTENANCE FOR SUSTAINABLE AND FLEXIBLE OPERATION OF HYDROPOWER PLANT (Di-Hydro)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Greece,France,Italy,Serbia,Romania,Spain,Cyprus
Call: Development of digital solutions for existing hydropower operation and maintenance (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 5748897.86
EU funding (EUR): 4498761.0
Participants: 13
Project status: SIGNED

Di-Hydro contributes towards harnessing the full potential of hydro-power (HP) plants and clusters in line with the objectives of the European Green Deal and the Paris Agreement, by development of tailored, optimized digital and smart decision-making tools for use in such plants, at scale. Indeed, Di-Hydro will develop smart devices and pro-active intelligent algorithms that utilize data acquired from static, dynamic, and alternative sources (e.g., satellites) so as to predict the operational and maintenance-related behavior of standalone HP plants and clusters, and we will then incorporate such algorithms in digital twins that can fully interrelate with such HP plants/clusters, yielding, eventually, an intelligent, fully-replicable decision-making tool for optimal coordination of environmentally mindful power generation from such plants/clusters (based on the foreseen market needs and the intended commercial strategy of their owners). Notably, a wide variety of previous plant digitization levels, weather and water flow conditions, biodiversity, environmental and societal issues pertinent to such HP clusters are incorporated in the integrated practical solution developed here, mainly by leveraging innovative sensor technologies, cutting-edge digital adaption for energy production, and optimized operation and maintenance practices based on next-gen information technology. The consortium is comprised of 13 partners, 3 of which are RTOs, 7 SMEs, and 3 large power enterprises (represented here by their hydro-power branches).

Keywords: hydropower plant,operation and maintenance,digital,sensors,monitoring,environmental and socio economic sustainability
Neuronal dynamics of learning and memory in the mammillary body (LearnMamBo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-07-01
End date: 2031-06-30
Duration (months): 60.0
Total project cost (EUR): 1492673.0
EU funding (EUR): 1492673.0
Participants: 1
Project status: SIGNED

At the heart of our individual personalities lie our memories – be it our first time riding a bike, the school graduation ceremony, or yesterday’s football match. Yet, it is estimated that in the coming decades up to 150 million people worldwide will suffer from dementia. To tackle this surge and identify therapeutic interventions, a thorough understanding of the neuronal mechanisms underlying long-term memory storage is necessary. Research in humans and rodents has identified the hippocampus as the brain’s preeminent structure for memory processing. Yet, for memories to become permanently stored and correctly retrieved, the hippocampus needs to communicate with the rest of the brain. One of the main projection targets of the hippocampus is the mammillary body (MB). Over a century of clinical research and lesion studies in rats have established the importance of the MB to form and retrieve long-lasting memories but its peculiar anatomical location has prevented research to uncover the mechanisms underlying this role. In this research programme, we will reveal the role of the MB in memory processing at a cellular, circuit, network, and behavioural level in mice. First, we will make use of recently established genetic tools to ascribe precise causal roles for memory processing to individual mouse MB subnuclei. Next, we will leverage my extensive experience with in vivo two-photon microscopy to image calcium activity from identified MB neurons across multiple days of learning. We will then combine these tools to elucidate the role of reciprocal brainstem inhibition. Lastly, we will use high-density silicon probe recordings to simultaneously record activity across cortical, thalamic and hippocampal sites connected to the MB, as animals are actively engaged in memory tasks. Overall, our research will deliver mechanistic insights into how the MB aids memory processing, which will prove critical for our understanding of how the brain can form life-long memories.

Keywords: mammillary body,ventral tegmental nucleus,papez circuit,spatial memory,optogenetics,hippocampus
Transformative Environmental Monitoring to Boost Observations in Africa (TEMBO Africa)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Innovation actions
Countries involved: Netherlands,Kenya,Greece,Slovakia,Italy,Zambia,Germany,Ghana
Call: New technologies for acquiring in-situ observation datasets to address climate change effects (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 3460931.25
EU funding (EUR): 2939922.0
Participants: 12
Project status: SIGNED

Objective: Set up cost effective innovative sensor networks that can be financed by climate services built on top of these networks. Concept: Transformative new methods to measure five essential hydrological variables (rainfall, soil moisture, river flow, bathymetry) at less than 10% of current costs. These reduced costs are essential to have realistic business models for services that cover the costs of building and operating the networks. The five essential variables will be available through GEOSS. Innovation: Seven new sensing methods will be introduced in Africa. The innovation does not focus only on moving up Technology Readiness Levels of new measuring methods but, especially, on the usefulness and practical applicability of these methods in the specific contexts. The direct linkage of sensors and new value-creating services is part of this innovation because this is essential for long-term financial sustainability. New services assimilate in situ and satellite data in numerical models to make optimal use of strengths of different sources of information. Knowledge of the African market: Building on earlier research-oriented projects and on experience in development of geo-services in Africa, in-depth knowledge of the opportunities and limitations of the African market is widely available within the consortium. Selection of focus services was based on this knowledge. These focus services are Flood Early Warning Systems, reservoir management, and crop germination insurance. These have been selected as the most promising services in the broader climate-oriented areas of geo-hazards, water management, and agricultural information.

Keywords: africa,value chains,sustainability
Precision control of glycosylation to open a new era of therapeutic antibodies (GlycoBoost)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Croatia
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-04-01
End date: 2027-09-30
Duration (months): 30.0
Total project cost (EUR): 3570771.97
EU funding (EUR): 2499540.38
Participants: 2
Project status: SIGNED

​​Biologics comprise a $511B market of advanced therapeutics that are used to treat cancer, autoimmune diseases, infectious diseases and beyond. Two thirds of biologics are decorated with sugar molecules attached to the therapeutics, including all antibody therapeutics, called monoclonal antibodies (mAbs). These sugar molecules are known as N-glycans and are vitally important for therapeutic safety and efficacy. To date, the N-glycans are poorly controlled and, as such, display highly heterogeneous patterns on a therapeutic. This complicates large-scale production and regulatory approval of biologics, and significantly limits the possibility of using N-glycans in therapeutic design. GlycoBoost revolutionises mAb design by delivering consistent N-glycans, precisely profiled with advanced analytical techniques. This innovation unlocks the full potential of N-glycans to elevate the effectiveness of mAbs. Kyron.bio’s breakthrough technology uses cell engineering to produce therapeutic proteins with uniform and precision-controlled N-glycan patterns. This technology is being used to produce glycoengineered mAbs that are safer and more effective for patients, starting with mAbs used to treat autoimmune diseases where patient resistance to current treatments remains high. Through a well-established collaboration between kyron.bio and Genos, one of the world leaders in glycoanalytics on whose SYSCID project this proposal is built, GlycoBoost aims to advance the project to commercialisation through the development of advanced glycoanalytical techniques, preclinical evaluation, pre-industrialisation, bespoke customer PoC’s, partnership-building, and fundraising. GlycoBoost will place Europe at the heart of the glycobiology revolution, leading to the development of safer and more effective treatments for autoimmune diseases and ultimately redefining the landscape of therapeutic drug development.

Keywords: glycosylation glycans glycoanalytics glycoengineering antibodies therapeutics biologics pharmaceuticals rheumatoid arthritis immunogenicity cho cells bioproduction drug design
Dissect the impact, safety and effectiveness of gene therapy at the whole organismal level by cell-free DNA signatures (TalesfromDeath)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Gene therapy (GT) with integrative vectors has emerged as a revolutionary intervention for the treatment of inherited and acquired disorders. Despite the great achievements, a major challenge pertains to the heterogeneity of responses that can be obtained in patients. The success of these applications critically depends on the ability of engineered cells to functionally integrate within the patients’ tissues to re-establish the physiological functions. Intrinsic features of the cellular drug product, and inter-individual factors present at the time or after cell infusion may modulate the clinical outcome. The proposed investigation aims at characterizing cell-free (cfDNA) signatures in patients who underwent GT. Epigenetic studies on cfDNA will capture the organism-wide changes induced by disease progression and consequent to the treatment in a non-invasive fashion. Furthermore, the retrieval of integration sites on cfDNA will provide molecular insights into the activity, clonality and persistence of engineered cells in peripheral organs. The translational relevance of this proposal will be directly assessed in unique clinical settings represented by patients treated with hematopoietic stem cell GT for the correction of inherited metabolic disorders, and with engineered T-cells to fight hematological and solid tumors. By correlating patient-derived cfDNA signatures with clinical variables outcomes, I will establish if these analyses can predict the impact of engineered cells at the whole organismal level potentially highlighting mechanisms of therapeutic success and failure that have not yet been explored. The advanced knowledge gained with this project may prompt a more accurate diagnosis evaluation, assist in selecting patients who will benefit from GT, and provide early insights on the efficacy and toxicity of cellular therapies guiding for a more personalized therapeutic intervention to reduce inter-individual variability.

Keywords: cell free dna biomarker gene therapy metabolic disorders car t
Antibiotic Lead Optimization (AnLeadOp)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The bacterial sliding clamp (DnaN) is an innovative target for the development of novel antibiotics, which are urgently needed to overcome the alarming antimicrobial resistance crisis. In the previous ERC starting grant (NovAnI), we discovered a novel DnaN inhibitor (WAM-N17) with promising broad-spectrum antibacterial activity including multidrug-resistant (MDR) pathogens. In this PoC project, we will optimize the antibacterial potency and spectrum and characterize the in vivo pharmacokinetic (PK) and pharmacodynamic (PD) properties of the WAM-N17 class so as to develop preclinical lead candidates for the treatment of bacterial infections, especially those caused by MDR germs. To achieve this goal, we will pursue three main activities. (i) Design and synthesis of 25–30 compounds (in two rounds) with modifications focusing on improving the anti-Gram-negative activity as well as target identification through chemical probes to further validate DnaN and identify other potential targets in bacteria. (ii) Evaluation of antibacterial activity, target binding/inhibition, and in vitro ADME-T (absorption, distribution, metabolism, excretion, toxicity) characterization for all new compounds. The frontrunners will be profiled for antibacterial activity against an extended panel of Gram-negative and MDR clinical isolates and subjected to mode of action (MoA) and target-identification studies. The most promising ten compounds will be submitted for in vivo PK studies and the best two lead candidates will be tested in a proof-of-concept in vivo efficacy study using relevant infection mouse models. (iii) Ultimately, we will file a patent to secure our intellectual property rights and continue to move this class of compounds forward into preclinical and then clinical studies in collaboration with a pharmaceutical industry partner. The knowledge that will be gained from this PoC project is essential to develop an urgently needed new antibiotic with an unprecedented mode of action.
Abortion, Law and Nature (ALaN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland,Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2027-11-30
Duration (months): 42.0
Total project cost (EUR): 342729.12
EU funding (EUR): 342729.12
Participants: 4
Project status: SIGNED

The ALaN project brings together philosophy, gender studies and life sciences to question the impact of representations of nature on women's health and rights, starting from the specific case of abortion. The objective is to renew the philosophical approach to abortion, to enlighten the European public debate thanks to an interdisciplinary and intersectoral research. [1] Starting from a philosophical clarification of the notion of "nature", it will question the representations of nature that underlie the debates on abortion in order to open up the possibility of a dialogue between Gender Studies and biomedical sciences. [2] The project will rely on this renewed approach to abortion to compare the sources available at the level of the EU and the Council of Europe (incl. ECHR) to define abortion rights, and examine the representations of the body that emerge from these sources. [3] Confronting law with obstacles women actually encounter when they seek abortion, the project will set up an ethnographic study at family planning centres (FCPPF, Belgium), to measure the impact of legislation on women's lives and health, and to test the hypothesis that the legislator has a role to play in advancing gender equality. [4] This research will lead to a six-month non-academic placement as a consultant and a network facilitator at FCPPF, that will lead to the publication of a European Guideline. The research strategy adopted is innovative: interdisciplinary (renewing key philosophical concepts by integrating data from other disciplines, esp. biomedical sciences); intersectoral (comparing legislation to the reality on the ground); "bottom-up" (making room for women's lived experience through ethnographic investigation and collaboratoing with non-profit organizations). The project will produce 6 articles, a monograph, 2 conferences, several seminars and a podcast for the general public.

Keywords: sex and gender,philosophy of law,abortion,reproductive rights,idea of nature