Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction (BAMI)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: United Kingdom,France,Belgium,Germany,Spain,United Kingdom,Germany,Czechia,Denmark,Italy,Poland,Germany,Belgium,Finland,Norway,Spain,United Kingdom,Belgium
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-11-01
End date: 2017-10-31
Duration (months): 72.0
Total project cost (EUR): 7842161.4
EU funding (EUR): 5993083.0
Participants: 22
Project status: CLOSED

Although the long term prognosis of patients suffering acute myocardial infarction (AMI) has improved since the introduction of reperfusion therapies and primary angioplasty, the 1 year mortality of patients with AMI and resultant left ventricular systolic dysfunction (LVSD) is still as high as 13%. A major reason for the high morbidity and mortality is that the heart has an inadequate regenerative response to the myocardial necrosis sustained following AMI; cell death from the ischaemic damage can lead to progressive ventricular dilation and dysfunction through the processes of vascular remodelling. Despite the use of full conventional treatment, including ACE inhibitors, beta-blockers, aldosterone inhibitors and diuretics, yearly mortality rates of patients with post-infarction heart failure are still in the range of 13 % and rehospitalisation for worsening of heart failure occurs at a yearly rate of 6–8%. Clinical data now exists supporting the concept that autologous bone marrow derived cells can restore cardiac function following AMI. We plan to advance this research in the BAMI project and will: • Develop a standardised method of bone marrow cell collection • Develop a standardised method of optimising reparative potential of bone marrow derived cells • Standardise bone marrow preparation procedure so that it can be universally applied • Standardise method of bone marrow cell delivery post AMI • Conduct the first large scale all-cause mortality clinical trial to test if the product and delivery method mentioned above can lead to a 25% reduction in mortality end-point at 2 years Our project will establish the therapeutic value of this approach to stem cell therapy. Success will demonstrate that transcoronary infusion of bone marrow-derived progenitor cells is safe and will reduce the mortality rate by 25% and reduce the rehospitalisation rate by 15%.

Keywords: intracoronary reinfusion bone marrow-derived mononuclear cells acute myocardial infarction autologous cell therapy
Predictive Genomic Biomarkers Methods for Combination Bevacizumab (Avastin) Therapy in Metastatic Colorectal Cancer (ANGIOPREDICT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Ireland,Belgium,Germany,Netherlands,Germany,Netherlands
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-02-01
End date: 2016-01-31
Duration (months): 48.0
Total project cost (EUR): 7993254.67
EU funding (EUR): 5999155.75
Participants: 11
Project status: CLOSED

In recent years the treatment paradigm for metastatic colorectal cancer (mCRC) has evolved in complexity to include newly developed targeted therapeutics. In 2004 bevacizumab (bvz) [Avastin] became the first anti-angiogenic drug to be licensed in malignant disease, based on the results of a randomised trial in advanced metastatic colorectal cancer. Nevertheless, over the past six year period emerging data now indicates that bvz fails to produce an enduring clinical response in a high proportion of patients. Delivery of the drug as part of a combination treatment regimen in mCRC elicits transitory improvements in the form of tumour stasis or shrinkage. Inevitably however, the tumours begin to re-grow and the disease progresses. It is now universally agreed that the future use of bvz in mCRC (and other cancers) is likely to be greatly influenced by the availability of predictive biomarkers to allow selection of patients who will attain the greatest benefit. The ANGIOPREDICT paradigm relies on a modular platform for the integrated discovery and validation of predictive pharmacogenomic biomarkers for combination bvz therapy in mCRC. Through initiation of a multi-centre clinical trial, early discovery findings will be validated for markers of Intrinsic Resistance to therapy. Parallel optimization of companion in vitro diagnostic tests (IVDs) through exploitation of proven SME development and validation strategies will ensure a cross-sectoral benefit to the cancer patient, prescribing physician and more broadly, across European and global public health networks. Crucially, leading SME partners will expand business portfolios into a well-defined market, progress novel intellectual property and access several in-licensing opportunities. ANGIOPREDICT uniquely unites world-class molecular diagnostic biomarker discovery SMEs with leading clinical and academic entities to identify a new generation of individualized methods for predicting response to combination bvz therapy.

Keywords: metastatic colorectal cancer,combination therapy,bevacizumab,angiogenesis,predictive pharmacogenomic biomarkers,patient stratification
Listening to the Future: Next-generation Sound Synthesis through Simulation (NESS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1477477.0
EU funding (EUR): 1477477.0
Participants: 1
Project status: CLOSED

This proposal is concerned with simulation-based approaches to sound synthesis, in the interest of generating very high quality synthetic sound of a natural acoustic character—partly to emulate real instruments, but also to explore classes of sounds which cannot be produced using conventional synthesis methods, or acoustic instruments. A further goal is to introduce such physical modelling synthesis methods definitively into the world of electronic music, virtual environments, and to the greater public. Target systems to be studied and simulated include: highly nonlinear acoustic systems (brass instruments, and percussion based on plate and shell vibration; electromechanical instruments; full 3D acoustic spaces; embedding of instruments within 3D spaces in order to achieve fully virtual and spatialized audio; and finally modular connections of systems in order to allow the eventual user, a composer, an instrument design environment. Such complex systems, including strong nonlinear effects, have never before seen a rigorous exploration from a numerical synthesis perspective. This proposed project is of an interdisciplinary nature, and rooted in music, numerical analysis, time-domain simulation, and high-performance computing. Work will be carried out at various levels: a) theoretical work and time domain algorithm design, with special attention paid to the appropriate choice of model, efficiency and real time operation, and various issues critical in audio, including: adequate perceptual rendering of system responses at audio sample rates; aliasing; robust algorithm design, ensuring numerical stability under highly nonlinear conditions; and modular constructions. b) large-scale parallel implementations on multicore processors and general purpose graphics processing units (GPGPUs), and c) experimental testing through collaborative work with established composers of electronic music, leading to performances original multichanel and fully synthetic music.

Keywords: sound synthesis,audio signal processing,gpgpu,high-performance computing,physical modeling
Identification of epigenetic markers underlying increased risk of T2D in South Asians (EPI-MIGRANT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,Italy,Finland,Australia,United Kingdom,Singapore,Sri Lanka,Mauritius,India,Japan
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-12-01
End date: 2014-11-30
Duration (months): 36.0
Total project cost (EUR): 3903100.4
EU funding (EUR): 2999052.0
Participants: 13
Project status: CLOSED

This project focuses on identification of epigenetic risk factors underlying the increased rates of type-2 diabetes (T2D) amongst South Asians in their home countries, migrants to Europe and other parts of the world. Known environmental and genetic factors explain only a small part of the increased risk of T2D among South Asians, who constitute the highest numbers of people with T2D worldwide. We hypothesise that epigenetic modification contributes to the increased T2D risk amongst South Asians. We will carry out an epigenome-wide scan of DNA methylation in whole blood, among T2D cases and controls from non-migrant (living in India or Pakistan) and migrant (living in the UK) South Asians. Further testing of top-ranking markers will be carried out in South Asian T2D cases and controls from UK, India, Mauritius, Pakistan, Singapore and Sri Lanka. We will use results to investigate the mechanisms underlying the epigenetic modifications identified, to develop a predictive panel of lifestyle, environmental, genetic and epigenetic markers increasing susceptibility to incident T2D in South Asians, and to quantify the contribution of these risk factors to T2D amongst South Asians in diverse regional settings. This research will improve understanding of epigenetic mechanisms underlying T2D, and may enable development of novel biomarkers and therapeutic strategies to reduce the burden of T2D amongst South Asians worldwide.

Keywords: biomarkers,epigenomics,diabetes,south asians
Asymmetric microenvironments by directed assembly: Control of geometry, topography, surface biochemistry and mechanical properties via a microscale modular design principle (ASMIDIAS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1484100.0
EU funding (EUR): 1484100.0
Participants: 1
Project status: CLOSED

The interaction of cells with the extracellular matrix or neighboring cells plays a crucial role in many cellular functions, such as motility, differentiation and controlled cell death. Expanding on pioneering studies on defined 2-D model systems, the role of the currently known determinants (geometry, topography, biochemical functionality and mechanical properties) is currently addressed in more relevant 3-D matrices. However, there is a clear lack in currently available approaches to fabricate well defined microenvironments, which are asymmetric or in which these factors can be varied independently. The central objective of ASMIDIAS is the development of a novel route to asymmetric microenvironments for cell-matrix interaction studies. Inspired by molecular self-assembly on the one hand and guided macroscale assembly on the other hand, directed assembly of highly defined microfabricated building blocks will be exploited to this end. In this modular design approach different building blocks position themselves during assembly on pre-structured surfaces to afford enclosed volumes that are restricted by the walls of the blocks. The project relies on two central elements. For the guided assembly, the balance of attractive and repulsive interactions between the building blocks (and its dependence on the object dimensions) and the structured surface shall be controlled by appropriate surface chemistry and suitable guiding structures. To afford the required functionality, new approaches to (i) topographically structure, (ii) biochemically functionalize and pattern selected sides of the microscale building blocks and (iii) to control their surface elastic properties via surface-attached polymers and hydrogels, will be developed.The resulting unique asymmetric environments will facilitate novel insight into cell-matrix interactions, which possess considerable relevance in the areas of tissue engineering, cell (de)differentiation, bacteria-surface interactions and beyond.

Keywords: biomaterials engineering
Impact of Prenatal Stress on BRAIN AGEing (BRAINAGE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Belgium,United States,Austria,Netherlands,Spain,Netherlands,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-03-01
End date: 2017-02-28
Duration (months): 60.0
Total project cost (EUR): 3880676.8
EU funding (EUR): 2998420.0
Participants: 10
Project status: CLOSED

Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ageing; (2) this predisposes to age-associated brain diseases including cognitive decline and stroke; (3) epigenetic changes affecting glucocorticoid receptor (GR) sensitivity, altered autonomic nervous system (ANS) reactivity and cerebrovascular tone are important mediators of these processes, (4) these changes represent targets for diagnosis and therapeutic interventions. Our consortium has unique access to well-defined human and non-human primate cohorts (age range 25-115 y equivalents) that have been exposed to different types of prenatal stress. For experimental analysis of mechanisms of prenatal programming, we apply innovative techniques to characterize brain ageing, namely MRI based volumetry, non-linear analysis of EEG and ANS, advanced molecular techniques including epigenetics and metabolomics and neuropsychological and behavioral tests. Human subjects, non-human primates and rodents (including transgenic models) exposed to maternal stress, glucocorticoids or undernutrition are examined in order to: (1) determine structural (MRI based volumetry) and functional (metabolomics, brain function, cerebrovascular tone) indicators of brain age, (2) relate them to susceptibility to stroke and cognitive decline, (3) determine to what extent GR resistance, stress sensitivity, and cerebrovascular contractility mediate premature brain ageing and disease susceptibility; and, (4) dissect mechanisms and pharmacological interventions relevant for aged subjects. Data from the study allow to identify subjects at risk for premature brain ageing and to initiate interventional therapy.

Keywords: fetal programming,brain ageing,epigenetics,dutch famine cohort,non-human primates,transgenic animals,stroke,hpa axis,therapeutic interventions,next generation sequencing,metabolomics
Composition and Sources of Atmospheric Organic Aerosol and their Negative Health Effects (CORANE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2017-09-30
Duration (months): 72.0
Total project cost (EUR): 1495851.0
EU funding (EUR): 1495851.0
Participants: 1
Project status: CLOSED

Atmospheric aerosol particles are key components of the earth’s climate system and are one of the major air pollution components. In both areas large uncertainties are associated with aerosol effects. The chemical composition is a major parameter determining the effects of aerosols on the climate and their health effects. A major but poorly defined fraction of the aerosol is organic material formed within the atmosphere (so-called Secondary Organic Aerosol, SOA). Only a comprehensive chemical analysis of SOA simulated in laboratory experiments can rigorously identify and quantify SOA sources. However, only a small minority of the SOA mass can be characterized on a molecular level due to fundamental limitations of conventional analytical-chemical techniques. Thus, there is a large uncertainty how accurate current laboratory experiments mimic atmospheric SOA. This uncertainly critically limits our ability to assess the role of aerosols in the climate system, to determine their toxicity and also constrains further improvements of legal limits for ambient particle concentrations. The main SOA sources will be identified in this project in unprecedented detail by developing novel analytical techniques to characterize SOA comprehensively (mainly ultra-high resolution mass spectrometry). Generation of SOA in improved laboratory experiments and comparison with field samples will help to overcome the long-standing uncertainties described above. Particle properties responsible for health effects are poorly understood, but oxidizing particle components are likely important in understanding particle-cell interactions. Compound classes in SOA will be quantified, which are potentially damaging biological tissue such as peroxides and radicals, using the strongly improved laboratory conditions to simulate accurately SOA. For these studies new, fast online spectroscopic techniques will be developed to accurately quantify these highly reactive and short-lived particle components.

Keywords: aerosol particles secondary organic aerosol mass spectrometry air pollution health effects
Efficient megahertz coherent XUV light source (MEGA-XUV)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Switzerland
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-03-01
End date: 2017-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Coherent extreme ultraviolet (XUV) light sources open up new opportunities for science and technology. Promising examples are attosecond metrology, spectroscopic and structural analysis of matter on a nanometer scale, high resolution XUV-microscopy and lithography. The most promising technique for table-top sources is femtosecond laser-driven high-harmonic generation (HHG) in gases. Unfortunately, their XUV photon flux is not sufficient for most applications. This is caused by the low average power of the kHz repetition rate driving lasers (<10 W) and the poor conversion efficiency (<10-6). Following the traditional path of increasing the power, numerous research teams are engineering larger and more complex femtosecond high-power amplifier systems, which are supposed to provide several kilowatts of average power in the next decade. However, it is questionable if such systems can easily serve as tool for further scientific studies with XUV light. The goal of this proposal is the realization of a simpler and more efficient source of high-flux XUV radiation. Instead of amplifying a laser beam to several kW of power and dumping it after the HHG interaction, the generation of high harmonics is placed directly inside the intra-cavity multi-kilowatt beam of a femtosecond laser. Thus, the unconverted light is “recycled”, and the laser medium only needs to compensate for the low losses of the resonator. Achieving passive femtosecond pulse formation at these record-high power levels will require eliminating any destabilizing effects inside the resonator. This appears to be only feasible with ultrafast thin disk lasers, because all key components are used in reflection. Exploiting the scientific opportunities of the resulting table-top multi-MHz coherent XUV light source in various interdisciplinary applications is the second major part of this project. The developed XUV source will be transportable, which will enable the fast implementation of joint measurements.

Keywords: xuv generation,ultrafast laser,mode locking,nonlinear optics,high power laser,high field science,high harmonic generation,phase matching,attosecond science,xuv imaging,frequency combs
Mathematical Aspects of Kinetic Theory (MATKIT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 1150000.0
EU funding (EUR): 1150000.0
Participants: 1
Project status: CLOSED

The main goal of the project is to reach a better mathematical understanding of the (integro)-partial differential equations from kinetic theory, in particular their qualitative and asymptotic behavior, derivation from many particle systems, and singular limits. Although various evolution problems from physics shall be considered, the paradigmatic ones are the Boltzmann equation for gas dynamics and the Vlasov-Poisson equation for plasmas and galactic dynamics. The methodology is focused on the developement of conceptual tools and mathematical techniques. It shall put therefore the emphasize on the structures common to several problems, with a view to their possible application to other fields of mathematical analysis. The methodology is also characterized by the search, whenever possible, of constructive quantitative methods of proofs, and by the attention payed to the qualitative meaning of the mathematical results obtained for physics. The tasks related to the general goal of the project are organized into the following four parts: I. Space-independent kinetic equations for describing microscopic interactions (Cauchy problem for long-ranged interactions, granular gases and self-similarity). II. Transport equations and phase mixing (Landau damping for Vlasov equations, inviscid damping for 2-dimensional incompressible fluids). III. How transport and collisions mix: hypocoercivity (spectral and stability analysis of hypocoercive collisional operators according to the local equilibrium space and the geometry of confinement). IV. Derivation of kinetic equations (mean-field and Boltzmann-Grad limits by semigroup approach). I have been involved in many recent progresses related to these aspects and I aim at constructing a team around me in order to achieve these tasks and objectives. Kinetic theory is developing a growing rate, and the construction of such a team in Europe would be timely.

Keywords: kinetic theory,boltzmann equation,vlasov equation,vlasov-poisson equations,mean-field,cauchy theory,relaxation to equilibrium,hypocoercivity,hypoellipticity