Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Playfields: Prototyping a location based game for higher education. (Playfields)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-02-01
End date: 2017-07-31
Duration (months): 18.0
Total project cost (EUR): 149681.0
EU funding (EUR): 149681.0
Participants: 1
Project status: CLOSED

The idea for this Proof of Concept (PoC) is to develop a prototype of a location-based game (LBG) that can be used for teaching fieldwork in a Higher Education (HE) setting. The rationale behind it is that location-based games, understood here as pervasive games in which gameplay develops through a player's mobile location, are promising educational tools for fieldwork, as they: - Are close to student’s lifestyle as digital natives - Offer innovative and creative technologies for using methods in vivo. - Offers educators possibilities to monitor and supervise students’ progress - Allow for different interactions between students, teachers and learning environments - Allow for more creative learning processes for understanding environments and people - Offer accessible and informal ways to break down barriers between researcher and “researched” The game we envisage to prototype will consist of an OpenStreetMap based GPS enabled mobile phone app that can be used by students while conducting fieldwork. The game mixes spatial and qualitative approaches, that prompt students to complete certain educational tasks, plan routes , create narratives, or “claim” certain spots or areas. The app will then feed data created by the students (GPS check-ins, images, texts, recordings) back to a main computer where the findings and activities are collected, scored with points and evaluated by the teachers of the course. Through this central interface organisers of the course as well as BOTs (automated tasks/non-playable entities in the game-world) can send messages, advise and tasks to the participants, information that is also used to share and evaluate the results with students in the classroom. Likewise students can communicate with their supervisors while in the field through this central interface to ask for advise.

Keywords: serious games,games for education
Deciphering the Molecular Foundations and Functional Competence of Alternative Human Naïve Pluripotent Stem Cells (CELLNAIVETY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

An important goal of stem cell therapy is to create “customized” cells that are genetically identical to the patient, which upon transplantation can restore damaged tissues. Such cells can be obtained by in vitro direct reprogramming of somatic cells into embryonic stem (ES)-like cells, termed induced pluripotent stem cells (iPSC). This approach also opens possibilities for modelling human diseases in vitro. However, major hurdles remain that restrain fulfilling conventional human iPSC/ESC potential, as they reside in an advanced primed pluripotent state. Such hurdles include limited differentiation capacity and functional variability. Further, in vitro iPSC based research platforms are simplistic and iPSC based “humanized” chimeric mouse models may be of great benefit. The recent isolation of distinct and new “mouse-like” naive pluripotent states in humans that correspond to earlier embryonic developmental state(s), constitutes a paradigm shift and may alleviate limitations of conventional primed iPSCs/ESCs. Thus, our proposal aims at dissecting the human naïve pluripotent state(s) and to unveil pathways that facilitate their unique identity and flexible programming. Specific goals: 1) Transcriptional and Epigenetic Design Principles of Human Naïve Pluripotency 2) Signalling Principles Governing Human Naïve Pluripotency Maintenance and Differentiation 3) Defining Functional Competence and Safety of Human Naïve Pluripotent Stem Cells in vitro 4) Novel human naïve iPSC based cross-species chimeric mice for studying human differentiation and disease modelling in vivo. These aims will be conducted by utilizing engineered human iPSC/ESC models, CRISPR/Cas9 genome-wide screening, advanced microscopy and ex-vivo whole embryo culture methods. Our goals will synergistically lead to the design of strategies that will accelerate the safe medical application of human naive pluripotent stem cells and their use in disease specific modelling and applied stem cell research.

Keywords: cell therapy,ipsc,pluripotency,embryonic stem cells escs,stem cell differentiation,epigenetics,reprogramming,trophoblast stem cells,germ cells,pgcs,dna methylation
Rheological Monitoring of Chronic Respiratory Diseases (RheoCare)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Chronic respiratory diseases are expected to become the third cause of mortality worldwide by 2020. Patients experience periodic acute exacerbation phases favouring infections of the lower airways and causing irreversible loss of pulmonary capacity. These crises cannot be forecast with current techniques and require emergency hospitalisations, leading to healthcare costs (€24k per crisis) and antibioresistances due to wide-spectrum treatments. Among respiratory diseases, we choose to target cystic fibrosis (CF) in Europe as organised care structures pre-exist. CF also represents a very attractive market segment of $4.5B across the Group of Eight (G8). Rheonova develops a unique monitoring test based on the rheology of lung secretions (mucus). The RheoCare project will provide a dedicated plug-and-play rheometer, with a quantitative biomarker and a specificity above 80%, allowing a point-of-care CF monitoring test within 10 minutes as a first step towards personalised healthcare. Our four-patent-protected technique already assesses treatments efficiency and is commercialised to researchers. Phase 1 clinical trials have demonstrated the reproducibility and the robustness of our biomarkers. Two new clinical protocols (Phase 2) proceed in order to demonstrate the medical benefit for the patient, i.e. the reduction of hospitalisations by predicting the exacerbation phases and assessing treatment performance quantitatively. Within three years, Phase 3 clinical trials will support the commercialisation of the device in EU and China. We will address the medical market with an attractively-priced machine accompanied with specific consumables needed to test mucus samples. To support our ambition, we need to implement an automated sample manipulation device. Three priority tasks remain to complete the feasibility study: (i) remoulding the software, (ii) supporting our commercialisation plan, and (iii) defining the IP strategy regarding this new building block.

Keywords: cystic fibrosis,rheology,monitoring device
Plastic in Agricultural Production: Impacts, Lifecycles and LONg-term Sustainability (PAPILLONS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Italy,Germany,Spain,Italy,Greece,Slovenia,China,Belgium,Finland,Poland,Norway,Czechia,Czechia,Netherlands,Netherlands
Call: Emerging challenges for soil management (H2020-SFS-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 7266740.0
EU funding (EUR): 7075861.75
Participants: 20
Project status: SIGNED

PAPILLONS will elucidate ecological and socioeconomic sustainability of agricultural plastics (APs) in relation to releases and impacts of micro- and nanoplastics (MNPs) in European soils. We will advance knowledge on sources, behaviour and impacts through cross-disciplinary research, bringing together scientists from chemistry, materials engineering, agronomy, soil ecology, toxicology and social sciences. We will transform the scientific knowledge generated into guidance on specific solutions by applying a Multi-actor approach, involving actors in the agricultural and policy sector and world-leading industries. This will enable co-creation of knowledge and provide the scientific background to enable policy, agricultural and industrial innovation towards sustainable farm production systems. We will deliver the first digital European atlas of AP use, management and waste production to estimate sources of MNP to agricultural soils. We will run integrative studies at laboratory, mesocosm and field scales in different parts of Europe to address: occurrence of AP-derived MNPs; MNP behaviour and transport in soil; uptake by biota and crops; long-term impacts on soil properties, fertility and ecological services; effects on biological and functional diversity across multiple scales; effects on plant production and quality; and socioeconomic impacts of AP-based practices. We will focus on multigenerational effect studies for relevant traditional and biodegradable polymers, at realistic and future high-exposure scenarios. PAPILLONS partners pioneered soil MNP research, host the majority of European analytical capacity for assessing soil contamination and will provide validated, high-throughput analysis for MNPs in soil. Using innovative applications of state-of-the-art analytical chemistry, we will advance analysis down to the nanoscale range and develop novel radiolabelled nanoplastics for accurately tracking behaviour and transport in soil and uptake by biota and crops.

Keywords: micro plastic,nano plastic,agricultural plastic,plastic chemical additives
International Energy Agency support action for clean energy transitions in emerging economies (CETEE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: France
Call: Contribution to the IEA & Energy Transition Support (H2020-IBA-Energy-IEA-2019, 2019)
Start date: 2020-01-01
End date: 2022-09-30
Duration (months): 33.0
Total project cost (EUR): 3774994.61
EU funding (EUR): 3500000.0
Participants: 1
Project status: SIGNED

This H2020 funded Coordination and Support Action (“Action”) is intended to assist a select number of emerging economies to implement actions to fulfil global clean energy and climate targets, in line with the Paris agreement. Built on a foundation of fact-based insights and tangible recommendations, the Action’s objective is to guide policy makers on how to push ahead in sector reforms, attract investments, foster innovation and ultimately enable a clean energy transition in selected emerging economies. In addition to this focus on policy makers, the Action is also intended to support policy implementing stakeholders such as regulators, system operators, local authorities and developers. A broader audience will also benefit directly and indirectly from certain data and other deliverables produced and made publicly available under the Action. The Action is intended to focus on a number of specific regions and topics, with a particular focus on major emerging economies (such as China, Indonesia, Brazil and India). Throughout this proposal these countries are referred to as “priority countries”. The intended specific objectives of the Action are to: • create more effective knowledge and information sharing and create capacity to enable stronger policy action and alignment of investment flows, including via country-specific reviews of policies, supported by scenario modelling where relevant; • strengthen international energy and climate plans in a way that complements existing initiatives, support multilateral efforts to facilitate and enable National Determined Contribution (NDC) implementation, increase collaboration between experts across priority countries and share relevant global expertise; • encourage innovation for the promotion of clean energy technologies and related investments; and • enhance and build upon an existing analytically rigorous evidence base for policy action, via statistics, indicators, and improved capabilities for data analysis.

Keywords: innovative indicators of the clean energy transition,power sector analysis and system integration of renewables,regulation,market design,investments and financing,energy innovation policies
Touch and pressure sensitive material without electronic sensors for intuitive and eye-free control of a car’s features while driving (Tangi0)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Current in-car controls have many individual components and parts included, making them very costly to assemble. If even one of the parts fails the controls won’t work and car models could be recalled by the factory to have to fix the issue. The assembled components are difficult to take apart and need to go through a timely, costly process to be recycled and not be turned into e-waste. The main problem behind in-car controls are that they cause significant distractions to drivers which has been found the cause of 80% of road traffic accidents. The problem is only becoming worse with infotainment displays imbedded with multiple lights and sensors and controls being inputted through a large touch-screen device. Tangi0 have developed a new method for operating controls in the cockpit of cars through an intuitive, tactile material with distinctive shapes that allow drivers to operate it eye-free. This reduces the safety hazards of driving distractions. Using a touch-sensitive, conductive material also means that there is a huge reduction in electronic components needed in the product making a much cheaper, environmentally friendly. Following a very promising preliminary validation of the innovative technology with Jaguar-Land Rover, Tangi0 now intend to develop and design the integrated system and fully commercialize the solution by reaching the market in 2021. Incorporated in the UK in 2015 with its core business in the European automotive market with a revenue of €200K, £450K in funding and a staff headcount of 8. The proposed work in Phase 1 of the SME instrument fits into the overall Tangi0 plan to reach market by contributing the financial resources needed to plan a fast, sound and wider deployment of the solution and the market uptake. It will also allow the SME to accomplish key feasibility activities and reduce the business risks, such as business planning, customer identification and outreach, and stronger IP management strategy.

Keywords: automotive,materials,controls,touch sensitive
Biohybrid phytosensing system for plant-technology interactions in mixed-reality and smart-home systems (Biohybrids)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Germany
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2019)
Start date: 2020-05-01
End date: 2021-10-31
Duration (months): 18.0
Total project cost (EUR): 99960.0
EU funding (EUR): 99960.0
Participants: 1
Project status: CLOSED

This innovation is related to an embedded electronic system connected to plants and trees – so-called phytosensor -- which measures their physiological parameters as well as different environmental values. Measured data are processed in the local device based on stored models that enable recognizing environment/plant states leading to normal vital activities, stress or decay of biological organisms. The system is used as a bio-sensor and as a bio-hybrid interface device. In ecological and bio-sensing usage, the phytosensor enables a biological monitoring of indoor conditions or urban/forest ecologies for early detection of environmental pathogenicity, pollutions or impact of human activities on environment. As a bio-hybrid interface, the phytosensor provides physiological data from plants for plant-technology interactions: Mixed Reality or smart-Home systems, integration into digital infrastructures, controlling the robot actuators or performing autonomous phytoactuation. Fully operational prototypes of phytosensors are produced and tested in multiple locations during 24 months in indoor and urban applications. These tests demonstrated a large social and ecological impact as well as a technological readiness for a global B2B and B2C market within entertainment, smart home and sensor equipment segments. This proposal describes an exploitation strategy that increases economic and societal benefits of the Flora Robotica project. The phytosensor system is a finalist of the Innovation Radar 2019.

Keywords: biohybrid systems,intelligent plants,smart home system,advanced sensors,embedded computing,biological sensors
Rapid on-site detection of Mycotoxin in wheat (MycoQuest)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Hungary
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-09-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The business of our company is agricultural trading. We realized that our sector lacks a reliable, fast, on-site detection method of Mycotoxins, in particular of deoxynivalenol (DON) in wheat grains, which is one of the major threats to the food and feed sector. We aim to commercialize a Mycotoxin (DON toxin) sensor unit, which is easy to use on-site, provides results with more than 90% accuracy compared to conventional laboratory HPLC method in the whole measurement range, while keeping its selling price low (at 10.000€). Our pilot technological tests and preliminary business planning envisaged a huge business potential of our project. In this phase 1 project, we plan to carry out technological feasibility study, market and risk assessment, freedom to operate study as well as to develop a phase 2 proposal and improve our business plan.

Keywords: mycotoxin,deoxynivalenol,food safety,wheat processing
A disruptive nutrigenetic solution for ageing well (Nutri4g)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The increased life expectancy in Europe means that a growing number of Europeans suffer from general health problems for the elderly. There are a number of diseases that are generally age related, are very prevalent in society and cause high rates of mortality. Our scientific team has selected to focus on nine diseases that are most common in the elderly and can be prevented by specific diets. We have developed the Nutri4g online platform, based on our own algorithm, allowing us to provide a complete service, in which, beginning with a test that determines genetic predisposition to 9 diseases (performed without extractions of blood), we offer the customer dietary guidelines that are genetically customized and scientifically tested by dietitians, in order to prevent diseases associated with the elderly. Nutri4g is a disruptive low-cost solution specializing in identifying genetic predispositions to diseases common to the elderly, after having measured their predisposition to 9 diseases in a single genetic test and providing personalised nutritional guidelines for each customer. To achieve the scalability of the service, we have developed a Tele-nutrition platform that optimizes the process and allows us to reach thousands of customers in different countries Phase 1 of SME Instrument represents a good opportunity to get a thorough business plan to minimize risks and to set up a plan for international commercialization. If the result of the feasibility study is positive, we will apply to phase 2 in order to implement our international expansion.

Keywords: telecare nutrigenetics ageing well nutrigenomics diet dietitian nutritionist genetic test platform
Fast Proof Reading and Correction of Complex Delineations (FastProof)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2018-01-01
End date: 2019-06-30
Duration (months): 18.0
Total project cost (EUR): 149648.0
EU funding (EUR): 149648.0
Participants: 1
Project status: CLOSED

This project aims at turning the novel approach to automated delineation of complex curvilinear structures we have developed under ERC funding into industrial-grade software that can be commercialized. Our primary goal will therefore be to transform our research software into user-friendly plugins with well-defined APIs that can be bundled with widely used commercial software platforms. In the neuroscience and biomedical areas, we have identified three such platforms and will explore potential licensing agreements with the companies selling them. In the field of aerial cartography, we have close links to an EPFL spin-off company that could help us break into this very different market. We will also investigate the feasibility of launching a new startup company to carry out any further development that might be required. To this end, we will conduct a market study to assess the size of the market and develop a business plan.

Keywords: delineation,neuroscience,biomedical imaging,cartography