Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIO-MICRO: Biomarkers and Intervention Outcomes in Micronutrient Optimization (BIO-MICRO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Germany,Ireland,Italy
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 4356399.39
EU funding (EUR): 3933202.32
Participants: 14
Project status: SIGNED

European micronutrient (MN) guidelines explicitly recommend to replete any MN deficiency in critically ill patients. MNs are crucial for immune defence, cellular metabolism and as antioxidant. Critically ill patients have increased requirements for MNs which can result in severe deficiencies and worse clinical outcomes. There are currently no accurate methods to diagnose MN deficiencies in critically ill patients. MN plasma concentrations are substantially affected by inflammation. MN concentrations in erythrocytes and leukocytes or new functional markers may better reflect real deficiencies. Furthermore, most intervention trials with high-dose MN monotherapy yielded mixed results on clinical outcomes. Due to the absence of accurate monitoring tools of MN body status, all patients received fixed high-dose MN monotherapy. Personalized MN therapy based on subphenotyping of patients and accurate estimation of individual metabolic demands in all phases of disease may yield better outcome than this one-size-fits-all strategy. In addition, more insight in the complex interplay between MNs and the role of MNs in post-ICU phase is necessary to guide future trials. BIO-MICRO consists of physicians, biologists, methodologists, trialists, health scientists, clinical chemists, patient representatives and industrial participants and aims to train innovative research fellows with interdisciplinary and intersectoral skills to develop the urgently needed strategies for MN personalized therapy in critically ill patients. They will develop new analytics for reliably determination MN body status, investigate subphenotypes of patients likely to benefit from MN therapy, enable guidance with appropriate timing of MN therapy, investigate the interplay between MNs and explore the role of MNs in the rehabilitation phase. This will ultimately lead to significantly decreased mortality and organ dysfunctions, shorter ICU stay, improvement of quality of life and significant cost reductions.

Keywords: micronutrients,personalized medicine,biomarkers,inflammation,redox status,oxidative stress
digital based bio-waste derived meta-PANels Towards A REvolutionary building Identity (PANTAREI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Luxembourg,Netherlands,United Kingdom
Call: EIC Pathfinder Challenge: AEC digitalisation for a new triad of design, fabrication, and materials (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3085000.0
EU funding (EUR): 3085000.0
Participants: 6
Project status: SIGNED

Buildings wield substantial influence on the environment, accounting for a hefty 30% of global energy usage and a consequential 19% of greenhouse gas emissions. To combat this looming crisis, the Net-Zero Energy Building (NZEB) concept emerges as a transformative paradigm shift in the world of construction. In the midst of this environmental renaissance, a digital revolution sweeps across manufacturing, presenting a tantalizing prospect of reducing embodied CO2 and enhancing thermal control. Yet, a considerable chasm separates these cutting-edge digital technologies from structures crafted from sustainable materials. The intricacies of computational and algorithmic design struggle to encapsulate the rich tapestry of Nature multi-scale marvels, the very essence of this green metamorphosis. Bridging this gap could boost digital fabrication to a mass production system, but issues include the complexity of multi-scale modeling, reliability uncertainties, technical limitations in 3D printing, and poor solution versatility. PANTAREI project addresses all these challenges by implementing a revolutionary adaptive intelligent computational irreversible thermodynamics paradigm to design and assess novel bio-waste-derived meta-structures for the reduction of embodied CO2 in buildings. PANTAREI over-arching aim is to extend the capabilities of current computational tools for material design, by developing adaptive solutions based on the intertwining of virtual physics of failure and non-equilibrium thermodynamics principles for the bio-waste multi-scale meta-structure design and tailored realization through the entire structure life-cycle with a human-centered perspective. This could be materialised only with the aid of a multi-disciplinary stakeholder coalition, which involves renowned universities and companies, leaders in computational/digital design of multi-scale meta-structures and sustainable manufacturing.

Keywords: net zero energy building adaptive modeling bio waste meta material multi scale 3d printing
Survival response to global change among tetrapods (ECTOGLOB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom,Canada
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 2
Project status: SIGNED

General background – Global change is at the centre of the alarming declines of many tetrapod species, especially ectotherms (amphibians and reptiles). To date, however, the demographic processes underlying the global declines of tetrapods as a whole, and ectotherms especially, remain poorly understood, limiting our ability to quantify, predict, and manage extinction risks. Gaps and challenges – Global change factors (climate, habitat degradation) are likely to have major deleterious effects on vital rates such as adult survival, a key parameter in population dynamics and a strong predictor of species extinction risk in endotherms. Yet, our understanding of these processes across tetrapods remains limited, mainly because demographic data on ectotherms have long remained scarce and disparate. Aims of the project – In ECTOGLOB, I will (1) develop the ECTOLIFE web platform, an open-access tool for storing, preserving, and promoting the use of demographic data on amphibians and reptiles; (2) assess how adult survival predicts demographic resilience and extinction risks of tetrapods in general, and ectotherms more specifically; and (3) analyse how the thermoregulatory mode mediates the influence of climate and human footprint on adult survival, expecting more severe impacts in ectotherms. Methods – The project builds on my past research, relying on the ECTOLIFE database that I have developed over the last 8 years. ECTOLIFE compiles longitudinal and transversal data from 1,555 populations of 527 species of amphibians and reptiles worldwide. Using adult survival estimates from ECTOLIFE data and those of endotherms from published studies, I will conduct large-scale comparative analyses, taking advantage of key methods developed by my host and secondment. Projected impacts – ECTOGLOB will shed light on major mortality processes involved in tetrapod biological crises, and will facilitate the development of further international research projects via the ECTOLIFE platform.

Keywords: demography,ectotherms,global change,meta analysis,tetrapods,survival
Deep Earth’s Oxygen recycling at subduction Zones (OZ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

In contrast to other known terrestrial planets, the Earth's interior is oxygen-breathing through the sink of oxidised tectonic plates at convergent margins since the late Archean to Paleoproterozoic. Recent estimates suggest that the redox capacity of some key subducting chemical elements is not balanced on geological time scales by global magmatism and volcanism, thus implying a puzzling deep oxygenation of our planet. Although current models presume that the redox state of subducting slabs is irreversible, my most recent results demonstrate that mixing of fluids from different slab lithologies can dramatically change the redox capacity of such fluids and the deeply subducted residues. The OZ project will provide an unprecedented quantitative framework to account for such interactions in order to determine the effectiveness of subduction slab fluids to oxidise the mantle wedge and generate the most oxidised magmatism on Earth: arc magmatism. To achieve this ambitious goal, OZ will address four specific goals: (1) the experimental determination of the effect of oxygen (fO2) and sulphur (fS2) fugacity on the stability of critical mineral assemblages during the prograde metamorphic evolution of serpentinites by using a novel triple capsule buffering technique in high pressure experiments; (2) the determination of sulphur mobility at high pressure due to gradients in fO2 and fS2 by means of an original experimental capsule design with interconnected reservoirs representative of the heterogeneity of the slab; (3) the characterization of sulphide-oxide mineral associations in natural samples from exhumed paleo-subduction terranes to demonstrate the scales of fluid mixing in nature; and (4) the upscaling of these processes to subduction zones by using two types of equilibrium reactive transport models at the scale of the slab and the mantle wedge.

Keywords: subduction zones redox processes serpentinites volatiles
Leveraging artificial intelligence to help asset managers better grasp the complexity of financial markets and make informed investment decisions (Ai For Alpha)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-03-31
Duration (months): 10.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Ai For Alpha is a solution based on the latest artificial intelligence techniques to help investment professionals in their management decisions. From our previous experiences in finance, we realised that information flows faster and faster and is sometimes contradictory. It is impossible as a human to analyse all these different signals at the same time to anticipate their impact on the markets. Our vision is that today, in an increasingly complex world, the asset manager needs the machine to outperform his process. This is augmented intelligence. In our view, the machine will not replace the manager, it is a decision support tool. We have developed a Deep Learning solution to help managers analyse the impact of a considerable quantity of market data (economic and financial data, changes in prices in commodities, currencies, volatility, credit spreads, etc.). Depending on market conditions, the model helps the manager to anticipate regime changes and adapt to the market environment in order to determine the best investment timing. The significant advantage of our solution is that the manager can see which market information explains the regime expectations at any time. Unlike other AI models that are often black boxes, the manager here understands the model's decisions and has a better understanding of the market's drivers. The solution has been validated by Société Générale's research teams. SG uses it to propose innovative investment solutions to their clients. The solution is also deployed for a French asset management company (Homa Capital). Ai For Alpha has calibrated its equity strategy to anticipate regime crises in the different markets and adapt its asset allocation according to market conditions. Our objective now is to scale our solution and develop it for other clients.

Keywords: artificial intelligence asset managers financial markets market information investment decisions augmented intelligence
Integrating bio-inspired assembly into semiconductor manufacturing technology for biosensors (BIOASSEMBLER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Finland,Austria,Germany,Portugal
Call: Development of technologies/devices for bio-intelligent manufacturing (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 3265740.25
EU funding (EUR): 3265740.25
Participants: 6
Project status: SIGNED

Bio-Intelligent Manufacturing Processes for multiplex MEMS biosensors
Refining Olive Mill Waste Lignin with Natural Deep Eutectic Solvents for Advanced Bio-Based Food Packaging Films and Nanoparticles for Plant Protection (OLinWASTE-LIGNADES)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Portugal
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 36.0
Total project cost (EUR): 599317.5
EU funding (EUR): 599317.5
Participants: 2
Project status: CLOSED

The OLinWASTE project develops a zero-emission biorefinery that transforms byproducts from olive oil production into high-value products, including bioimmunostimulants, biopesticides, biofertilizers, bioplastics, and renewable energy, while significantly reducing emissions, odors, and noise. The HOP ON OLinWASTE-LIGNADES initiative enriches OLinWASTE by valorizing lignin-rich side streams such as pits, branches, and other processing residues that remained underutilized. The new partner, UAveiro, introduces a sustainable lignin valorization platform using Natural Deep Eutectic Solvents (NADES), eco-friendly solvents that are less odorous, have low toxicity, low volatility, and high biodegradability. Advanced computational and machine learning tools guide the selection of optimal NADES formulations for selective lignin extraction, enabling tailored fractionation and recovery of high-value lignin components. To ensure the sustainability of the processes, NADES recirculation and reuse will be explored, minimizing waste and environmental impact. The extracted lignin will be incorporated into polysaccharide-based functional films for food packaging applications. Lignin molecules will also be used to develop nanoencapsulated, bio-based bioprotectants, enhancing delivery, stability, and efficacy for plant protection. By providing innovative lignin-based biosolutions, the project reduces waste, emissions, and fossil dependence, supporting zero-waste, zero-pollution biorefineries while promoting sustainable and circular processing within the olive oil industry.

Keywords: olive mill wastes,lignin,natural deep eutectic solvents,biorefinery,functional films,food packaging,nanoparticles,antimicrobials,plant bioprotectants
Phytoplankton Towards Valorization of Ammonia-containing Liquid for Upgraded Economy (PhyToVALUE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Czechia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-17
End date: 2025-08-16
Duration (months): 25.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

Unicellular small plants, microalgae and cyanobacteria, have a great potential to valorize wastewater by producing high-value biomaterials using the contained nutrients. However, a high concentration of ammonia in wastewater exhibits strong toxicity to microorganisms and prevents the successful cultivation of algae. While dilution is the most prevalent solution, large consumption of freshwater resources is costly and not sustainable. Therefore, this project aims to develop a novel method to detect algal ammonia inhibition by fluorescence monitoring, which will enable direct feeding of undiluted ammonia-containing wastewaters by controlling the feeding rate. In this project, appropriate fluorescent methods will be screened first, and the screened methods will be applied to algal cells exposed to various types of inhibition. A multivariate statistical model will be constructed to distinguish ammonia toxicity from other inhibitions. For improvement of feasibility, a low-cost fluorescent monitoring device shall be also developed. Finally, the developed methods and devices will be integrated into a long-term ammonia feeding control experiment to evaluate the feasibility. During the implementation of the research project, the candidate will receive training both from the host institution (Universidad de Valladolid; UVa) and from the Centre Algatech (CA) where the external advisor belongs to. The candidate will further develop skills in process engineering in the training from UVa and learn the mechanisms of fluorescence from CA. The expected results of the project include a fluorescent algal toxicity identification tool, a low-cost fluorescent monitoring device, and the ammonia toxicity control protocol, all of which have a strong impact on the field of wastewater treatment, aquaculture, and algal mass cultivation. Successful development of proposed methods will enhance the utilization of waste for value creation, leading to the establishment of a sustainable society.

Keywords: algae,cyanobacteria,mass cultivation,wastewater treatment,valorization,circular economy,ammonia,toxicity,fluorescence,sensor,statistics,process engineering
The European Biodiversity Partnership (Biodiversa-plus)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: COFUND actions
Partnership: Biodiversa+ (co-funded)
Countries involved: Croatia,Czechia,Denmark,Estonia,Finland,France,Germany,Greece,Hungary,Iceland,Ireland,Israel,Italy,Moldova, Republic of,Bulgaria,Austria,Belgium,Latvia,Lithuania,Morocco,Netherlands,Norway,Poland,Portugal,Romania,Slovakia,South Africa,Spain,Sweden,Tunisia,Türkiye,Albania,Switzerland,Cyprus,Montenegro,Slovenia,Faroe Islands,Georgia
Call: European partnership rescuing biodiversity to safeguard life on Earth (HORIZON-CL6-2021-BIODIV-02, 2021)
Start date: 2021-10-01
End date: 2028-09-30
Duration (months): 84.0
Total project cost (EUR): 354589990.7
EU funding (EUR): 105000000.0
Participants: 81
Project status: SIGNED

Being one of the main actions of the EU Biodiversity Strategy 2030, the European Biodiversity Partnership (Biodiversa+) will coordinate research programmes between EU and its Member States and Associated Countries, mobilising environmental authorities as key partners for implementing biodiversity research and innovation, along with ministries of research, funding organisations, and environmental protection agencies (75 organisations from 37 countries). Biodiversa+ has five overarching objectives: (1) improve monitoring of biodiversity and ecosystem services across Europe (status and trends); (2) generate actionable knowledge to tackle the direct and indirect drivers of biodiversity loss; (3) expand and improve the evidence base, and accelerate the development and wide deployment of NbS to meet societal challenges across Europe; (4) make the business case for the conservation and restoration of biodiversity; and (5) ensure efficient science-based support for biodiversity policy making in Europe. Biodiversa+ will meet these objectives by (i) setting up a pan-European network of harmonized monitoring schemes, building on existing national/regional monitoring schemes, creating capacity for setting up new schemes, and feeding into the EC Knowledge Center for Biodiversity; (ii) coordinating research programmes between the EU and its Member States and associated countries, thereby ensuring the long-term pan-European research agenda is co-created and implemented; (iii) contributing science-based methodologies to account for and possibly value ecosystem services and the natural capital, and to assess the dependency and impact of businesses on biodiversity and (iv) better linking of R&I programmes to the policy arena, providing greater input to policy making and improving the assessment of policy efficiency. Doing so, Biodiversa+ will help ensure that, by 2030, nature in Europe is back on a path of recovery, and by 2050 people are living in harmony with Nature.

Keywords: biodiversity,nature based solutions,research and innovation,biodiversity monitoring,mainstreaming,stakeholder engagement,open science,eu biodiversity strategy 2030,evidence based policies