Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hopping on Artificial Intelligence Guided Develpment of Vanillin-based Flow Batteries - HOP-ON VanillaFlow (VanillaFlow_Hop on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Austria,Türkiye
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 18.0
Total project cost (EUR): 315437.5
EU funding (EUR): 315437.5
Participants: 2
Project status: CLOSED

TThe Grand Challenge ahead is to transition from fossil-fuel dominated, centralized energy systems to regenerative, integrated multi-vector grids. This shift demands sustainable electrical energy storage solutions, encompassing the entire supply chain of raw materials, processes, and systems. True impact on the economy, society, and environment is achieved only if materials, processes, and products can be scaled to meet large-scale demands. This poses a significant challenge for mid- to long-term, systems-integrated energy storage, especially as the EU heavily relies on critical raw materials from politically unstable regions. The Hop-on VanillaFlow project aims to extend the technological innovations of the EIC Pathfinder VanillaFlow project, which focuses on redox flow batteries (RFBs), by introducing regenerative fuel cells (RFCs). These RFCs combine fuel cell technology with RFB systems. The overarching goal of Hop-on VanillaFlow is to optimize operational conditions, improve cost-efficiency, and enhance overall effectiveness, all while prioritizing the use of safe and sustainable non-critical raw materials. Specifically, Hop-on VanillaFlow will leverage the AI-guided molecules developed in the VanillaFlow project to operate an organic RFC, with hydrogen as the fuel on the counter side. This approach opens up new applications and opportunities by modifying only a single component within the system, while maintaining the benefits of the original VanillaFlow innovations.

Keywords: redox fuel cells,redox flow battery,vanillin,artificial intelligence
Paludiculture demonstrations providing multi-actor approaches and recommendations towards large-scale deployment in the EU (PaluWise)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Innovation actions
Countries involved: Finland,United Kingdom,Netherlands,Poland,Lithuania,Latvia,Ireland,Germany
Call: Paludiculture: large-scale demonstrations (HORIZON-CL6-2024-CLIMATE-01, 2024)
Start date: 2025-02-01
End date: 2029-07-31
Duration (months): 54.0
Total project cost (EUR): 10273604.75
EU funding (EUR): 9999999.5
Participants: 19
Project status: SIGNED

The EU aims to cut greenhouse gas emissions (GHG) by at least 55% by 2030. This ambition requires fast mitigation measures within all sectors. Paludiculture is the productive land use of wet and rewetted peatlands and can reduce GHG emissions by up to 70-80%. It thus has a large potential to support the EU’s climate targets and biodiversity strategy and still provide farmers and landowners with income, but only if the practice is scaled up. Currently, there are too few large-scale sites involving local actors that demonstrate industrial scale paludiculture farming models. PaluWise's 4 large-scale paludiculture sites in Finland, the Netherlands, Poland, and the United Kingdom will showcase best practices and solutions for converting degraded organic soils to paludiculture. They develop field-scale operations and their associated five value chains (crops: Downy Birch, Reed, Sedges, Typha, Reed Canary Grass). By having two established (NL, UK) and two new sites (FI, PL), PaluWise can demonstrate different stages of paludiculture and associated value chains, emphasising replicability and scalability. Network sites (e.g., PaludiZentrale, Germany) will provide lessons learnt guidance and engage actors in innovating improvements (e.g. maintaining high water levels, adapting machinery, choosing suitable crop species). A multi-actor approach is applied to co-innovate and improve cost-effective, climate smart value chains. Activities cover the full sequence from deciding where to set up a site (WP1 decision support tool for rewettability), what works well in a site (WP2 demos), what are the benefits/impacts in emission reduction, carbon sequestration potential, biodiversity and other ecosystem services at landscape scale (WP3, WP4), and how to upscale and get support (WP5). We will identify barriers and provide recommendations to boost improved policy and legislation for large-scale deployment of paludiculture in Europe.

Keywords: paludiculture,rewetting,greenhouse gases,carbon sequestration,value chain development
Ampher Controller Technology (ACT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-01-01
End date: 2023-10-31
Duration (months): 22.0
Total project cost (EUR): 2428492.13
EU funding (EUR): 1686300.0
Participants: 1
Project status: CLOSED

Uptake of electric vehicles (EVs) depends on the availability of charging points. If charging the EVs is not possible, people will stop buying them. In some regions, the available grid capacity is already setting limits to how many EVs can be charged simultaneously. Current charging station controller technologies do not enable using the full available grid capacity. As much as 2/3 of it may remain unused. With such technologies, the only solution to grid congestion is to increase grid capacity, but this would cost billions and take decades. Ampher unique controller technology enables using the full available grid capacity and allows charging up to 6x more EVs simultaneously with the same grid connection than current technologies. This is achieved with breakthrough microcontroller and semiconductor technologies, instead of high investments into infrastructure. With Ampher controller, all EV charging stations can be made smart and European climate goals can be achieved.

Keywords: power electronics,smart grid,smart controller technology,ev charging technology
Accelerating Datacentre performance through Memory Chips to efficiently manage the Big Data Age (ENERGIA/PIM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 3566042.5
EU funding (EUR): 2496229.75
Participants: 1
Project status: CLOSED

Datacentres have become a backbone of the modern economy, they currently consume 2% of worldwide electricity, rising to 10% by 2030. While compute accounts for 40% of this energy, 80% of this compute energy is related to moving data between the main memory chips and the processor (CPU), a structural bottleneck within server design that causes slowdown and low CPU usage. Development of ground-breaking Processing-In-Memory (PIM) technology by UPMEM prevents this data movement by performing calculations in the memory chips, where the data resides. By eliminating the need to move data off chips, PIM bypasses structural bottlenecks. The power of UPMEM’s technology comes from leveraging existing industry protocols, chip technology and programing languages, and designing PIM modules that fit into standard memory slots. When compared to those using conventional memory, PIM equipped servers have proven to be up to 20x faster, 10x more efficient and cheaper for Big Data and AI applications.

Keywords: memory chips,processing in memory,data centres,big data,severs
Pushing Boundaries in BPL Derandomization (LBPL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

We propose to study one of the most fundamental problems in computational complexity theory: the BPL vs. L problem. Specifically, we aim to construct improved pseudorandom generators (PRGs) and weighted PRGs—a notion introduced by the PI and coauthors (STOC 18, CCC 21). In recent years, weighted PRGs have gained significant attention and played a central role in numerous advancements. Notably, the PI and coauthors leveraged WPRG techniques to improve the 30-year-old Saks-Zhou algorithm for iterated matrix multiplication (STOC 23). Despite a flurry of progress in recent years, achieving breakthroughs on such fundamental problems will likely require fresh and innovative approaches. In this proposal, we present novel ideas drawing from spectral graph theory, computational methods, and combinatorial techniques. Some of these ideas build on the PI's analysis of rotating expanders (STOC 23), and of the Zig-Zag and other graph products (FOCS 24, ITCS 25). These efforts are further supported by promising preliminary results. We also introduce a novel computational model, termed input catalytic machines, along with new PRG variants. These models hold the potential to shed new light on classical questions and the barriers that hinder progress. This adds a conceptual dimension to the proposal, increasing its likelihood of success. Furthermore, we propose to study key algorithmic problems, specifically focusing on their space complexity. While challenging, we are well-positioned to tackle these longstanding open problems. The PI has made significant contributions, including introducing WPRGs, improving the Saks-Zhou algorithm, and achieving breakthroughs on foundational questions such as Ramsey graphs and tree code construction (STOC 16, STOC 18). Additionally, the PI's deep expertise in advanced mathematical theories, such as finite free probability, underpins the spectral methods integral to this proposal.

Keywords: bpl,pseudorandom generators,derandomization,space bounded computation
Empowering the Circular Economy with Renewable Methanol for the Shipping and Aviation Sectors (ECOANOL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

PuriFire is pioneering a transformative technology in the sustainable fuel industry. PuriFire’s unique reactor system streamlines the production of green H2, and biogenic CO2 generated in-situ from waste water and carbon feedstocks. The outputs are then converted in a continuous, downstream process to create methanol or other sustainable aviation fuel. The core of the technology is a continuous hydrothermal gasification process, which applies high pressures and temperatures to flexibly operate under various conditions and produce green H2, biogenic CO2 and renewable fuels, including bio-methanol. This method is particularly efficient with wet feedstocks, such as digestate and sewage sludge, which would otherwise require energy-intensive drying. PuriFire’s approach eliminates the need for costly electrolysers and carbon capture systems, reducing CAPEX by 50% compared to similar technologies, while innovative heat recycling cuts energy consumption by up to 70%. PuriFire’s system stands out for its simplicity and adaptability, incorporating a plug flow reactor that maintains consistent pressure and volume, preventing issues like clogging and unwanted by-products that plague other systems. This, combined with its ability to utilize wet, low-cost feedstocks and industrial waste heat, positions the technology as a cost-effective and environmentally friendly alternative to conventional methods. Through the EIC Accelerator, PuriFire aims to scale its technology to a commercial demonstration plant producing 10,000+ tons of methanol annually by 2026, having already multiple patents and established key partnerships. Their technology promises to reduce the cost of green methanol by up to 40%, while offering significant environmental benefits, including a 95% reduction in CO2 emissions compared to fossil-based methanol. By supporting the circular economy and reducing dependency on fossil fuels, PuriFire’s innovation contributes to broader environmental and economic goals.

Keywords: renewable methanol,green hydrogen,hydrothermal treatment,reactor engineering,biobased,digestate
Non-Thrombogenic LAA Closure Device (ENDM_2025)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Atrial fibrillation (AF) affects over 15 million people worldwide and is responsible for up to 30% of all strokes. In most cases, blood clots form inside the left atrial appendage (LAA). Oral anticoagulants (OACs) are the current standard of care, but millions of patients cannot tolerate them due to bleeding risks or contraindications. Existing transcatheter LAA closure devices, such as Watchman and Amulet, leave foreign material exposed to the bloodstream, causing device-related thrombosis (DRT) and requiring prolonged anticoagulation—defeating their primary purpose. Endomatic Ltd. develops the world’s first truly non-thrombogenic transcatheter LAA closure system. Our proprietary intra-appendage suturing implant, delivered via a steerable double-curve catheter, achieves hermetic anatomical closure of the LAA without leaving any material exposed to the left atrium. The design mimics surgical suturing while maintaining the simplicity and safety of a catheter-based procedure. Pre-clinical and first-in-human studies have demonstrated complete sealing, tissue fusion, and zero DRT without post-procedure anticoagulation. The technology is protected by two international patent families covering the collapsing nitinol implant and its anchoring mechanism. It fits all LAA morphologies and can be performed under fluoroscopy with intracardiac echocardiography, enabling single-operator use under conscious sedation. Targeting a €2.8 billion global market, Endomatic removes the key limitation of current devices and can expand the treatable population five-fold. With EIC support, the company will finalize its next-generation delivery system, conduct multicentre European clinical studies, and scale manufacturing towards CE-Mark and FDA approval—establishing a new global standard for safe, durable stroke prevention in AF patients.

Keywords: interventional cardiology medical device structural heart stroke prevention electrophysiology
GAME-CHANGING IMMUNOTHERAPEUTIC ALLERGY VACCINES FOR TRANSFORMING ALLERGY INTO TOLERANCE (TOLERAIT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Allergies have become a widespread concern in today's world, with urbanization, dietary changes, and environmental shifts contributing to a significant rise in allergic conditions like allergic rhinitis, asthma, food allergies, and skin sensitivities. These issues affect the quality of life for millions, and current treatment options remain limited, with no known cure. Desentum, a pioneering biotechnology company established in 2011, is set to transform allergy treatment with its innovative approach, offering hope to allergy sufferers globally. Desentum brings together scientific expertise, strategic business insights, and visionary leadership to drive cutting-edge advancements in allergy therapy. Led by experienced leaders who have successfully launched multiple biotech innovations, we excel at navigating complex regulatory environments, forming strategic partnerships, and fostering sustainable growth. With extensive experience in mergers, global business development, and finance, Desentum is well-equipped to scale its innovations across various allergies and regions, positioning itself as a leader in the allergy therapy market. Our breakthrough hypoallergenic immunotherapies, often referred to as allergy vaccines, represent a significant milestone in allergy treatment. By re-engineering allergens at the molecular level, Desentum is revolutionizing the allergy treatment landscape, offering safer, faster, and more effective solutions. As we continue clinical development and trials, Desentum is paving the way for a future where allergies are no longer a source of fear and limitation but a manageable and potentially reversible condition.

Keywords: allergy,allergic rhinitis,allergen immunotherapy,ait,immunotherapy
High-performance self-healing and flame-retardant polymer materials for all-solid-state lithium metal batteries (PolyMat4Bat)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

The development of new energy vehicles is a strategic initiative addressing oil security, air pollution, and industrial upgrading, and is pivotal for achieving Europe's carbon neutrality goal by 2050. All-solid-state lithium metal batteries have significant advantages in energy density, safety, wide temperature range, and environmental adaptability. However, the interface between lithium metal and Li6.4La3Zr1.6Ta0.5O12 (LLZTO) still faces chanllenges, such as high impedance, side reactions, mechanical decay, lithium dendrites, and poor interfacial stability. Notably, the modification of this interface using self-healing polymers effectively alleviates the inevitable physical or chemical fatigue and interface damage, although it may introduce issues such as uneven Li+ nucleation and flammability. To address these challenges, the overarching goal of the ambitious yet feasible project (PolyMat4Bat) is to develop rapid self-healing, flame-retardant, and high-performance polymer films (CLSHPFs), which will be utilized between lithium metal and LLZTO. Specifically, this project will systematically investigate the self-healing mechanisms of CLSHPFs. The introduction of B-O bonds, Si-O bonds, and phosphorus-based structure is expected to enhance fire safety and chemical stability. Furthermore, electrochemical characterization, theoretical calculations, and in-situ/ex-situ characterization techniques (XPS, SEM, TEM, and Raman, etc) will be employed to elucidate the electrochemical reaction mechanisms, interface stability, dendrite growth inhibition, and Li+ deposition behavior. PolyMat4Bat is a typical multidisciplinary approach requiring complementary expertise from the host (flame-retardant molecular design, fire chemistry, polymer chemistry) and the researcher (electrodes design, battery assembly, and electrochemical characterization technologies), contributing to the achievement of the “Sustainable Development Goals” and “European Green Deal” of EU policies.

Keywords: flame retardancy fire safety self healing polymer all solid state lithium metal batteries
Ribosome Heterogeneity as a Determinant of Cellular Identity in Hematopoiesis and Leukemia (RiboID)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1700000.0
EU funding (EUR): 1700000.0
Participants: 1
Project status: SIGNED

Differentiation and acquisition of cell identity are fundamental processes in multi-cellular organisms. It is well established that chromatin and RNA mechanisms regulate cell fate determination. Mounting evidence from our lab and others, however, suggests that translation is an additional, until now underappreciated, determinant of cell fate. The importance of translation to differentiation can be gleaned from the hematopoietic system, where a prominent feature of human congenital syndromes, due to mutated ribosomes, is aberrant blood production. Crucially, these mutations lead to distinct cell-type-specific differentiation defects, rather than systemic failure. It remains unclear how congenital (“total-body”) ribosomal mutations only affect particular differentiation paths and manifest in a cell-type-specific fashion. We hypothesize that cell-type-specific ribosomal composition—i.e., ribosome heterogeneity—results in cell-type-specific translation profiles, and therefore represents a crucial layer of gene regulation in cell-fate and differentiation. We will explore this hypothesis by pursuing three complementary objectives: (1) Systematically map ribosome heterogeneity and reveal its function in normal hematopoiesis and leukemia; (2) Determine how ribosome heterogeneity controls cell-type-specific translatomes and contributes to cellular transformation; and (3) Explore ribosome heterogeneity at single-cell resolution, using novel methodologies we will develop for simultaneous transcription and translatome interrogation. By combining cutting-edge sequencing techniques with extensive genetic manipulations in physiological settings, we will reveal cell-type-specific translation, controlled by cell-type-specific ribosomes, as major regulators of cell fate in health and disease. Understanding the mechanisms of cell-type-specific translation will provide a new paradigm for elucidating gene expression regulation and for revealing new mechanisms for human diseases.