Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Building more reliable and performant batteries by embedding sensors and self-healing functionalities to detect degradation and repair damage via advanced Battery Management System (PHOENIX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Belgium,Germany,Türkiye,Italy,Spain,Switzerland
Call: Embedding smart functionalities into battery cells (embedding sensing and self-healing functionalities to monitor and self-repair battery cells) (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 4998505.75
EU funding (EUR): 4998505.75
Participants: 9
Project status: SIGNED

PHOENIX aims to develop battery cells with integrated sensors (mechanical, enhanced impedance spectroscopy, temperature, gas, reference electrode) and self-healing (SH) functionalities (magnetically activated polymers, thermally activated polymers, metallic organic frameworks coated separator, core-shell NMC composites). Tailor made triggering devices to activate SH mechanisms will be developed, prototyped and demonstrated in Generation 3b and 4a Li Ion batteries. A Battery Management System (BMS), capable of detecting defective operations and of triggering SH functionalities will be developed with in-line communication. The degradation detection and quality, reliability and life (QRL) will be tested through dedicated profiles (fast charging, extreme temperatures, calendar life). The novel batteries’ manufacturing will be studied from a recycling and mass production point of view. PHOENIX’s objectives: 1. Develop sensors to detect healable degradation mechanisms 2. Develop materials with SH functionalities triggered by external stimulus to eliminate/avoid failure mechanisms in battery cell components 3. Develop triggering devices to activate SH mechanisms 4. Demonstrate proof of concept for coupling sensors and SH agents via BMS 5. Detect critical degradation processes during cell ageing and estimate the QRL over the life span 6. Assess the environmental sustainability and demonstrate the competitive advantage over alternative approaches such as replacement, recycling or second use 7. Adopt an adaptable approach towards battery cells mass production processes which do not hinder the subsequent recycling process and enables an economic evaluation of the developed cells PHOENIX will collaborate with the BATTERY 2030+ initiative and will contribute to Europe’s competitive and sustainable battery manufacturing industry. PHOENIX consortium is a partnership of 4 RTOs, 1 university, 4 SMEs expert in materials, sensors, modelling, BMS, recycling and battery manufacturing.

Keywords: self healing,triggering,sensors,batteries,manufacturing,recycling,battery management system,sustainability,safety,lifetime,bms,quality,smart batteries
European Concept for Higher Altitude Operations Phase 2: Towards the integration between Air Traffic Management and Higher Altitude Operations (ECHO 2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Belgium,Italy,Spain,Germany,France,Sweden,Ireland,Portugal,United Kingdom
Call: Industrial Research & Validation for Air-Ground Integration and Autonomy (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 14849731.25
EU funding (EUR): 7030567.87
Participants: 25
Project status: SIGNED

The European airspace above FL550 is expected to become an area where operations will significantly expand as a result of increased new entrants presence representing both aviation and space domains, with estimated business values in the order of billions of euros per year. The European Air Traffic Management (ATM) system, including ATC’s operational procedures and systems, needs modernization and adaptation to allow seamless integration of Higher Altitude Operations (HAO) because of vastly different characteristics of vehicles and associated operational, safety and performance requirements. ECHO-2 will build on the deliverables of the ECHO (European Concept of Higher airspace Operations) project, starting from the Concept of Operations, to propose validated solutions paving the way towards the operational integration of HAO in ATM, on three directions: - Space Launch Real Time Monitoring Module and associated working station for the European ATM Network Manager for increased situational awareness at Network level, supporting Air Traffic Flow Management as well as crisis and contingency management. - Procedural Package covering specific ground and air-ground operational integration issues (including for communications, navigation and surveillance means) associated with the integration of High-Altitude Platform Systems (HAPS) operations into ATM - Procedural Package covering specific ground and air-ground operational integration issues (including for communications, navigation and surveillance means) associated with the integration of supersonic, hypersonic and suborbital vehicles operations into ATM. These solutions will propose all the elements needed by the European ATM Network operational stakeholders for a rapid, harmonized and cost-effective implementation of a European approach towards the integration between ATM and HAO, at TRL6 maturity. They will also include assessments of potential specific related standardization and regulatory activities.

Keywords: new entrants operational integration higher altitude operations supersonic hypersonic suborbital haps
Precision oncology of spatial immune escape mechanisms in ovarian cancer (SPACE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 2368459.0
EU funding (EUR): 2368459.0
Participants: 1
Project status: SIGNED

Tumor progression is dependent on the ability of malignant cells to escape the recognition and attack by the host immune system. The development of more efficient cancer immunotherapies has been hampered by the perplexity of immune escape mechanisms. I hypothesize that tumor genetic drivers dictate the immune escape mechanisms, and that these mechanisms can be exploited to develop more effective immunotherapeutic strategies for patients with high-grade serous ovarian cancer (HGSC), the most common and lethal ovarian cancer. My group has developed an optimized algorithm based on homologous recombination (HR) DNA repair deficiency to enable clinically meaningful stratification of the complex HGSC genotypes. We will define the immunogenicity of the HGSC genotypes via profiling tumor somatic mutations and neoantigens, the cell-type specific gene expressions, and T/B cell receptor diversities using altogether >600 HGSC samples. Using a cutting-edge highly multiplexed technology and advanced image analysis, we will reveal the single-cell spatial landscapes of the tumor microenvironment in 200 immunogenetically-defined HGSCs. We will apply pioneering spatial analyses on the single-cell data and use artificial intelligence to uncover clinically relevant spatial biology of HGSCs. Via transcriptomic profiling of 384 spatial microregions, we will discover the detailed immune-escape mechanisms of the HGSC genotypes. For functional testing, we have developed a groundbreaking method to establish immune-competent patient-derived organoids (iPDOs), which faithfully recapitulate the patients' tumors. Using our high-throughput iPDO functional platform, we will test mechanism-specific immunotherapeutic approaches and capture the treatment responses at single-cell resolution. The discovery and functional targeting of the immune escape mechanisms gives us unprecedented potential to open new horizons in immunotherapeutic targeting of HGSC.

Keywords: spatial biology,cancer immunotherapies,ovarian cancer,immune evasion,tumor immune interactions,tumor genetics,immunogenomics,single cell profiling,tumor microenvironment,patient derived organoids
EVTOL MULTI-FIDELITY HYBRID DESIGN AND OPTIMIZATION FOR LOW NOISE AND HIGH AERODYNAMIC PERFORMANCE (eVTOLUTION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Netherlands,United Kingdom,Belgium,Italy,Germany,Czechia
Call: Competitiveness and digital transformation in aviation – advancing further capabilities, digital approach to design (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3520000.0
EU funding (EUR): 3520000.0
Participants: 12
Project status: SIGNED

This project supports the digital transformation of aircraft design by developing new multi-disciplinary and multi-fidelity simulation tools that will enable novel aircraft architectures with improved aerodynamics and reduced noise emissions. This project addresses more specifically the design issues of electric Vertical Take-Off and Landing aircraft developed for Urban Air Mobility, but the innovative design/optimization framework that are proposed in this project are equally applicable to other novel aircraft architectures, such as those based on Distributed Electric Propulsion, Boundary Layer Ingestion, or open rotors. One common issue for most novel aircraft concepts is indeed the complexity of the aerodynamic and acoustic interactions between the lift-thrust systems and the airframe. eVTOLUTION is designed as a low-to-mid-TRL enabler project meant to develop the knowledge, data, tools, and methods that are necessary to understand, model, and optimize aerodynamic and aeroacoustic installation effects. The main objective of the project is to implement and demonstrate a novel design and optimization framework, built upon three pillars: (i) exploit the strengths of low-, mid-, and high-fidelity simulation methods at each phase of the design; (ii) accelerate the optimizations while preserving robustness thanks to data-driven surrogate models combined with physical models; and (iii) further consolidate the accuracy and robustness of the design and optimization using advanced experimental/numerical cross-validation and training methodologies. The realization of these objectives will be achieved through design exercises, defined by the consortium under the guidance of its aircraft manufacturers. The analysis of the design exercises will permit quantifying the gains achieved in terms of design cycle time, prediction accuracy, optimization robustness, the efficiency of the noise-mitigation technologies, and eventually the acceleration of the certification process.

Keywords: electric aircraft design,digital aviation,optimisation,multi fidelity simulation,evtol,machine learning,urban air mobility,distributed electric propulsion,aeroacoustic installation effects
WASTE QUANTIFICATION SOLUTIONS TO LIMIT ENVIRONMENTAL STRESS (WASTELESS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Portugal,Italy,Slovenia,Türkiye,Estonia,Spain,Belgium,Austria,Denmark,France,Czechia,Greece,Hungary,Switzerland
Call: Research and innovation for food losses and waste prevention and reduction through harmonised measurement and monitoring (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2023-01-01
End date: 2026-05-31
Duration (months): 41.0
Total project cost (EUR): 5458232.5
EU funding (EUR): 5458232.5
Participants: 30
Project status: SIGNED

The WASTELESS project will develop and test a mix of innovative tools and methodologies for Food Loss and Waste (FLW) measurement and monitoring. A bottom-up approach will be followed: starting from defining an harmonised methodological framework and set of standards for the testing activities, the evaluation of the tools implementation and the quality and integrability of the data produced in other frameworks and finally recommend sustainable policies and business strategies to set the ground for a harmonised Framework at EU level. Additionally to the measurement and monitoring tools, WASTELESS will carry research activities on innovative processes and streams to valorise unavoidable FLW. With the ambition to make existing FLW quantification solutions and WASTELESS ones usable by all food actors, it will be developed a Decision Support Toolbox for any stakeholders to access to the most appropriate methodology, digital tools and solutions for FLW valorisation all that aggregated with the Environmental and Socio-Economic impact associated to the implementation of the solutions. This will enable the replication of data collection hubs accross Europe feeding the model developed by JRC with robust, reliable and comparable FLW data.
Computational study of on-surface catalysis induced by ligh (PhotoSurf)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

On surface synthesis is an emerging field that aims to adapt traditional organic chemistry reactions to the fabrication of atomically precise low-dimensional nanostructures. This has been made possible thanks to the catalytic properties of surfaces and their 2D confinement. Despite the rapid development of this field, there are still key fundamental aspects that require additional efforts. One of the main problems is the strong interaction of nanostructures with the catalytic metal surface that results in a real impeachment for applications due to the difficulty of decoupling the nanostructures from the surface. To solve this, the community, and the host group, have turned its attention to the use of photoreactions on an insulator for the formation of these nanostructures and low-dimensional materials without the use of thermal catalyzed processes on a metal surface. The scientific objective of this fellowship is to develop computational tools to rationalize, and finally predict, possible photochemical reaction pathways of organic molecules deposited on surfaces. In particular we have three main objectives: create a virtual screening method for the study of molecular self-assembly on surface; study the effect of surface, substituent and self-assembly in the absorption spectrum of the molecule and a computational study of the photo reaction that can takes places on the surface. For these objectives we will take advantage of the computational tools developed during the phD and postdoc of the applicant for others fields, like biochemistry and wet chemistry, and apply them and develop new ones for the field of on-surface photochemistry together with the host-group . This synergistic approach, together with the experience and facilities of the host and collaborators, will lead to the successful completion of the project and to the strengthening the career development of the Researcher.

Keywords: on surface catalysis,photoreaction,self assembly,dft,qm mm
Microstructure-Informed Numerical Framework for Predicting the Response of TBC System (MIM-TBC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Among conventional power generation systems, gas turbine (GT)-based technologies provide the optimal balance between reliability, affordability, and, most importantly, flexibility in the face of a substantial proportion of variable renewable energies (VREs). In response to intermittent VREs, the operational profile of GT will shift towards higher ramp rates, more frequent peak-load/base-load cyclic operations, and a greater number of start-ups which will negatively affect the life cycle of hot components. On the other hand, to enhance efficiency, the turbine inlet temperature should increase from the current 1500℃ to 1800℃, exceeding the temperature limit of high-performance superalloys (1300℃) and imparting the severest thermo-mechanical loading on hot gas path components being coated with indispensable overlay or diffusion type thermal barrier coating (TBC) systems. Owing to the multifaceted and severe consequences of protective coatings failure, research to predict interrelated deformation, chemo-thermo-mechanical degradation and subsequent failure of TBC systems particularly under high-temperature thermal cycling is a top priority. Experimental durability tests, which are primarily based on empirical fitting of coatings mass loss data, are incapable of predicting the lifetime and long-term degradation of a TBC system. In light of the above circumstances, it is extremely beneficial to develop comprehensive modeling techniques that are capable of replacing time-intensive and limited-scope experimental endeavors. Among the different options available, MCrAlY-YSZ (with M being Ni or Co) arises as the most common protective coating system. MIM-TBC project aims at developing a mechanistic and microstructure-sensitive framework for predicting deformation, damage progression, and lifetime of the MCrAlY-YSZ TBC system. Specifically, the framework will be organized to achieve the following specific objectives: O1) A microstructure-sensitive framework for deformation analysis of MCrAlY-based TBC system under thermal cycling O2) Physically-based lifetime prediction of MCrAlY-based TBC system under thermal cycling.

Keywords: thermal barrier coating,crystal plasticity fast fourier transform,phase field modeling,damage,deformation
Targeting the undruggable: Leveraging neomorphic DNA-binding preferences of chimeric fusion oncogenes to promote cancer suicide (Cancer-Harakiri)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1992235.0
EU funding (EUR): 1992235.0
Participants: 1
Project status: SIGNED

Many aggressive cancers, such as pediatric high-risk Ewing sarcoma and alveolar rhabdomyosarcoma, are fueled by and addicted to chimeric oncogenic transcription factors (OTFs). So far, all attempts to suppress these potent OTFs largely failed, wherefore they are classified as undruggable. This proposal challenges this dogma with a novel strategy to leverage, rather than to suppress, the exquisite neomorphic DNA-binding preferences of OTFs to express therapeutic genes specifically in cancer cells. In pursuing three ambitious aims, this project goes far beyond an original proof-of-concept study in which we drove pediatric cancer cells in preclinical models into suicide (CANCER-HARAKIRI) via viral transfer of therapeutic genes induced by the specific interaction of an OTF with its neomorphic DNA-binding motif: In Aim 1, we will genetically engineer and functionally test a conceptionally advanced viral vector in vivo with optimized general design, oncotropism, and therapeutic payload focusing on immuno-oncological aspects. In Aim 2, we will comprehensively map the regulome of OTFs using novel reporter cell lines, single-cell sequencing, RNAi-screens, and CRISPR interference to identify and validate OTF-inhibiting genes that can be co-targeted in our vector to prevent escape variants with low OTF-activity. In Aim 3, we will integrate insights from Aims 1&2 into our new vector design, translate our therapeutic approach from our main model entity, Ewing sarcoma, to other OTF-driven cancers, and set the stage for GMP-compliant virus production and initiation of a clinical trial. This integrative approach combines expertise and technology across disciplines with original experimental tools to afford a comprehensive understanding of the OTF-regulome, and to rationally design and leap ahead an innovative therapeutic concept, which has the potential to revolutionize the therapy of metastatic OTF-driven cancers. Thus, we will exploit the undruggable to promote CANCER-HARAKIRI.

Keywords: ewing sarcoma,pediatric oncology,virotherapy,oncolytic viruses,oncogenic fusions,neomorphic dna binding preferences