Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A catalyst for EuropeaN ClOUd Services in the era of data spaces, high-performance and edge computing (NOUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Spain,Greece,Italy,Portugal,Belgium,Germany,Ireland,Slovenia,France,Luxembourg,Cyprus
Call: Integration of data life cycle, architectures and standards for complex data cycles and/or human factors, language (AI, data and robotics partnership) (RIA) (HORIZON-CL4-2023-DATA-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 8428875.0
EU funding (EUR): 8428875.0
Participants: 21
Project status: SIGNED

NOUS will develop the architecture of a European Cloud Service that allows computational and data storage resources to be used from edge devices and supercomputers through the HPC network and Quantum Computers. NOUS will be an Infrastructure-as-a-Service (IaaS)/Platform-as-a-Service (PaaS) cloud provider, harnessing edge computing and decentralisation paradigms to incorporate a wide array of devices and machines in its computational flow to provide leaps in Europe’s capability to process vast amounts of data. The pipeline of the NOUS in the project will include three types of components: i) computational components that are responsible for executing computations, ii) edge components that are responsible for communicating with edge devices (such as IoT sensors/ actuators/ devices), iii) data storage components that are responsible for data storage and storage management. Components are researched individually, expecting to yield breakthroughs, and jointly, to create the architecture and cloud-level services such as syndication with other platforms and virtual labs. The project has defined four use cases that will allow the testing of the developed technologies in real-world scenarios that industry leaders face. The NOUS architecture will be open source to allow companies and organisations to capitalise. Furthermore, a set of workshops and collaboration activities is envisioned with Data Spaces Support Centre, Gaia-X, FIWARE and EOSC powered by a strong consortium of 21 partners from 11 European countries.

Keywords: cloud architecture and services,hpc,quantum computing,edge computing,distributed federated concepts,ai,ml,blockchain,data management,data spaces,sharing,life cycle and economy,cybersecurity
A therapeutic software that delivers remote speech therapy to individuals with Parkinson's disease (Teleatherapy)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Ireland
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-03-31
Duration (months): 9.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Parkinson’s disease (PD) is the second most common neurological disease worldwide after Alzheimer’s and is the fastest growing one. Over 10 million people in the world are living with this disease, of which about 90% will experience difficulties with their voice as the disease progresses. At Teleatherapy, our goal is to make speech and language therapy accessible to all patients with Parkinson’s disease and to improve the service provided by speech and language therapy clinics. Our Teleatherapy platform aims to do this by allowing patients to practice therapy at home. Patient monitored through the platform enables therapists to receive key insights, saving therapists time and ensuring patients get the early intervention they require. Teleatherapy is a web-based care management platform allowing therapists to: customize care plans for patients; monitor their progress by assessing the strength of the individuals' voice; and provide feedback each time the patient practices and adjust care accordingly. In parallel, it allows clinics to: increase their caseload; personalize speech therapy plans; and maximise patient compliance by allowing them to practice speech therapy on our mobile app. This will contribute to a significant reduction in PD treatment costs for the healthcare systems and wait lists. PD Patients download a mobile app which delivers their care programme, analyses their voice, and tracks their progress for their therapist. Patients are guided through their practice with exercises, i.e. volume exercises, high and low pitch exercises, and practicing key every day phrases. Planned improvements to our Software as a Service will include the use of machine learning algorithms supporting enhanced voice analysis and progress monitoring, and the implementation of decision making and recommendation capabilities for therapists.

Keywords: speech and language therapy web based care platform mobile app loop closing technology therapy plans monitoring machine learning algorithms voice analysis clinical recommendation
A cheap, fast and reliable diagnostic test for Tuberculosis Infection (FastTBItest)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-03-01
End date: 2026-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Latent tuberculosis infection (TBI) occurs when someone is infected with Mycobacterium tuberculosis but does not have active TB disease. Those with TBI are at risk of developing active TB, with 8–10% progressing without antibiotic treatment, causing significant societal and economic impacts. Testing higher-risk groups, including immunocompromised individuals (e.g., those on immunosuppressive therapy, HIV-positive), close contacts with active TB cases, healthcare workers, and people from high TB prevalence countries (e.g., refugees), is crucial for TB control. The interferon-gamma release assay (IGRA) is a primary TBI test, detecting T cell immune responses to M. tuberculosis in blood. However, IGRA is technically challenging, requires long incubation times (24–48 hours), and incurs high costs (>100 EUR/test). These factors hinder the widespread screening of high-risk populations recommended by the WHO. We have developed a new technique, ProliSpot (patent pending), which detects antigen-specific T cell responses within several hours after collecting a blood sample and potentially overcomes the limitations of IGRA. This project's goal is to determine ProliSpot's in vitro diagnostic (IVD) potential for TBI testing. To achieve this, we will assess clinical feasibility by testing blood samples from TB patients and control subjects and compare the results with IGRA. Moreover, we will identify the subsequent steps needed for clinical development, particularly for the Investigational Medical Device Dossier (IMDD) and other requirements of the EU in vitro diagnostics regulations (IVDR). We will also perform pre-commercialization studies and define funding and networking strategies. Given that TBI testing is crucial for TB control, tens of thousands are screened annually in Europe, there is a societal need for increased TBI screening, and improved TBI testing methods are needed, the project's societal and economic impact is expected to be significant.
A thematic network to boost small-scale sustainable farming through sustainable cropping practices (Crop-MATCHING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Greece,Italy,Türkiye,United Kingdom,Bulgaria,Norway,Romania,Denmark,Spain,Poland,Portugal,Cyprus,Netherlands
Call: Thematic networks to compile and share knowledge ready for practice (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 3335598.26
EU funding (EUR): 2997562.5
Participants: 16
Project status: SIGNED

The overall objective of Crop-MATCHING is to set up a holistic approach to identify information, underutilized knowledge and best sustainable practices from small-scale farms, mix and match them into crop combinations (such as crop rotation, strip cropping, or vertical cropping) and generate new impartial and tailored knowledge specific to small farmers'/foresters' requirements. Crop-MATCHING by proposing successful and easy-to-use small-scale farming practices, aims to provide an ‘automotive’ solution to the problems smallholder farmers/foresters face in EU agriculture and at the same time, line up with the European Green Deal, Rural Vision, Climate policy and Farm to Fork strategy. What is of great concern is the fact that the number of small farms follows a sharp decrease. In this context small farms produce most of the healthy and biodiverse food that we eat every day, they provide local jobs and sustain rural activities, and they secure the resilience of our food system. Crop-MATCHING considering the important role of smallholder farmers/foresters and their need to have sustainably fair economic returns to continue farming activities and remain in the rural areas proposes the wide use of successful and easy-to-use farming practices. Through, the exploitation of various networks it is aimed to identify, diffuse, and convince farmers/foresters to adopt these successful practices. Through the proposed procedure, initially, the underutilised knowledge that appears in the literature (or identified in previous EU projects) will be mapped (more than 100 practices); almost all European territory and several pedoclimatic zones will be covered, as small and subsistence farms don't present the same structure and need everywhere. Conceptualized actions to communicate ready-to-use practices, through Crop-MATCHING, including digital cloud solutions, info packages, fact sheets, practice groups, open-access databases, e-learning, infographics, videos, website and social media.

Keywords: thematic network,small scale farms,sustainable cropping,best practices,cost effectiveness,automotive process,build trust,digitalisation,easily accessible,green deal,climate,rural vision
Studying the metabolism and function of myeloid dendritic cells and neutrophils in distinct tissues in health and aging (MyTissue)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499500.0
EU funding (EUR): 1499500.0
Participants: 1
Project status: SIGNED

Myeloid cells, such as dendritic cells (DCs) and neutrophils, reside in various organs to respond to insults and are key to control immunity and inflammation. However, their aberrant activities in the elderly can cause immunosenecence and inflammaging. Different tissues comprise highly distinct milieus that impose context-dependent biochemical challenges on their resident cells, which further change when tissues age. Yet, it is not known how DCs and neutrophils survive in their different homing organs and maintain their functionality. I hypothesize that DCs and neutrophils have to adjust their metabolism to the distinct environments of their tissues of residence. This is important, because metabolic changes upon stimulation were shown to affect the functions of those cells in vitro. Given their power to orchestrate immune responses, it is now vital to reveal the precise metabolic adaptions of DCs and neutrophils to their distinct homing organs and to determine how that affects their activities. This pioneering knowledge will expose organ-dependent metabolic vulnerabilities of DCs and neutrophils to uphold their homeostatic and immune functions, which I envisage to cause their dysfunction in aging. I will uncover the metabolic adaptions of DCs and neutrophils to >10 healthy and aged tissues using independent innovative approaches and adapted cutting-edge techniques. I will reveal the relevance of such tissue-dependent metabolic adjustments for their presence and functions in organs, and dissect the underlying molecular mechanisms. I will expose the tissue-specificity of DC and neutrophil dysfunction in aging and the role of their metabolism. The discovery of tissue-dependent metabolic adaptions by DCs and neutrophils that impact their functions will transform translational immunology research to integrate the tissue-context and reveal novel organ-specific therapeutic strategies to combat immune dysfunction in aging and beyond.

Keywords: tissue context,dendritic cells,neutrophils,metabolism
Frugal Artificial Intelligence and Application in Astrophysics (TITAN)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Greece
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Beneath the amazing colors of the beautiful images collected by telescope facilities in space and on remote mountaintops lie numbers, and lots of them. These data contain the scientific information astronomers need in order to reveal the physical properties of the Universe and the laws that govern its function. Recent advances in detector technologies and large focal plane CCD arrays enable astronomers to efficiently monitor a hyperspectral/multiwavelength view of the sky, thus opening the last unexplored window, the one of time domain in short time scales. This ability of daily monitoring big swaths of the sky over extended periods produces astronomical datasets at an astounding rate, revealing the transient and often violent face of the Universe. Hence, researchers need to develop more powerful computational and statistical methods to tackle the data, to get the big picture view out of the underlying science details. The TITAN project will appoint an outstanding researcher as the ERA Chair holder of Astroinformatics to incept and lead a research program in computational astrophysics and data science, which will couple, transform and expand two major research operations at FORTH - Computer Science and Astrophysics - while rooting an effective bridge between regional research excellence and international missions. Our grand vision is to create a true interdisciplinary, international and multicultural center of excellence for developing the tools, methods, and applications of computational science, machine learning, and statistics for research and education in data-oriented Astronomy. TITAN will fully unlock the potential of FORTH, the Cretan region and Greece through the implementation of a set of measures geared towards: capacity building (expansion of the research program, advanced training opportunities); institutional development and structural change; and intersectoral and international partnership activities in the field of Computational Astrophysics.

Keywords: astrophysics,astroinformatics,artificial intelligence,machine learning,radio interferometry,weak gravitational lensing,deep learning,signal processing,computational astrophysics,statistics
Macrophage blockade for the improvement of targeted radionuclide delivery to malignant tumours (RADBLOCK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2028-06-30
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

The aim of RADBLOCK is to improve nanocarrier-based radionuclide delivery by enhancing targeting and overcoming problem of non-specific uptake of nanoparticles by macrophages in liver and spleen. For this purpose, two approaches will be used simultaneously: 1) modification of radionuclide-loaded nanoparticles with targeted scaffold proteins, recognizing HER2 receptor expressed by malignant cells; 2) temporal blockade of the cells of the mononuclear phagocyte system (MPS) to decrease elimination of the nanocarrier. The results of the project will be beneficial to the diagnostics and treatment of tumours with overexpression of HER2 receptors, such as human breast and gastric/gastroesophageal carcinomas. This project is novel and innovative, since presents first application of macrophage blockade technology for improving of radionuclide delivery with nanoparticles. RADBLOCK is a multidisciplinary project and combines modern chemical methods of nanocarrier preparation, physical methods for the material analysis and its comprehensive biological evaluation at the animals, bearing human xenografts. The applicant will conduct research in Uppsala University under supervision of Prof. Vladimir Tolmachev, expert in radiopharmaceutics and clinical applications of targeted scaffold proteins. As a two-way knowledge transfer fellow will be trained in methods of radiochemistry and radiopharmaceutics and will bring experience with nanomaterials chemistry and macrophage blockade techniques to the host organization. RADBLOCK is expected to increase radionuclide blood bioavailability in mammals and enhance specific tumour delivery, which will have positive effects on targeted diagnostics and therapy of malignant tumours with radionuclides.

Keywords: nanoparticles radionuclides drug delivery macrophage blockade her2 targeting
How does the digital data-layer of digital-physical products and services shape collaboration and competition in industry-spanning ecosystems? (ECOdig)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Digitalization of industry, such as smart industry solutions, promises society sustainability and prosperity. To reduce resource consumption and increase operations’ reliability, organizations deploy digital technologies to monitor, control, optimize, and automate existing physical operations (e.g. sensors in factories for efficient production, maintenance, and IoT services). This often requires organizations to build or join industry-spanning business ecosystems, where the data-layer of the digital-physical offerings acts as “portal” connecting organizations across different industries (hardware/engineering, software/IT). Yet, we know little about how digital data enable these connections and how this shapes competitive dynamics. Furthermore, organizations have different origins, sizes, and structures, which fuels innovation but also confers unequal opportunities. This poses challenges to policymaking, because the emergence of industry-spanning ecosystems redistributes market dominance, so that powerful incumbents may block initiatives to remain dominant. To avoid a build-up of power by a few tech-platforms (e.g. Google, Amazon), we need to understand how different types of organizations use digital data and how differences shape ecosystem emergence and management. This is important, because competition based on digital data likely takes different forms than “traditional” strategies. Building on strategy, information systems, and organizational theory, this project develops an inductive framework to explain how digital data allow organizations to devise digital-physical offerings that straddle multiple industries. Based on interviews, observations, and archival materials in two digitalizing ecosystems that tackle this twin digital/green transition, this research answers the question: how does the digital data layer of digital-physical offerings allow organizations to enter and traverse industries, and what are the organizational and strategic implications?

Keywords: digital platforms,qualitative research,business ecosystems,digital data,information systems,layered modular architecture,digital disruption,digital transformation,digital strategy