Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Battery and Energy Management System for Second-Life Battery energy storage (iBEMS-SeLiBat)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-12-01
End date: 2025-04-30
Duration (months): 29.0
Total project cost (EUR): 1446250.0
EU funding (EUR): 1012375.0
Participants: 1
Project status: CLOSED

Octave’s product consists of a second-life battery energy storage system equipped with Octave’s cutting-edge battery and energy management technology. The novel technology relies on a deep integration of the battery management system and the energy management system. It makes the raw battery cell measurements available for optimisation of the battery system’s charging strategy. The data are sent to Octave’s battery cloud, where it is used in advanced machine learning methods and digital twins of the cells are created to extract useful insights. This innovative technology opens up a range of improvements in the operation of the system such as optimal control, extended lifetime, improved monitoring and enables predictive maintenance. It is particularly useful for second-life battery storage. The goal of this project is to bring Octave’s product to the market by lifting the technological readiness from TRL 5 to 8 and prepare the go to market via the blended finance modality.

Keywords: circular economy,second life battery cells,battery cell degradation,machine learning,big data
A Multi-Omics Approach for Novel Drug Targets, Biomarkers and Risk Algorithms for Myocardial Infarction (TargetMI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Malta,Netherlands
Call: EIC Pathfinder Challenge: Cardiogenomics (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 3999840.0
EU funding (EUR): 3999840.0
Participants: 2
Project status: SIGNED

In TargetMI we propose a high throughput multi-omic approach for rapid discovery of novel drug targets, biomarkers and risk algorithms, applied here to atherosclerosis, myocardial infarction (MI) and their risk factors. Cardiovascular disease is a major cause of death and morbidity worldwide. The causes of MI are highly complex involving genetic, lifestyle and environmental factors. Whilst much research effort has been invested in attempting to decipher these factors, clinical applications of findings are disappointingly few. We will harness four -omic datasets (whole genome, transcriptomic, metabolomic and proteomic data) on 1000 highly phenotyped samples of the Maltese Acute Myocardial Infarction (MAMI) Study. These were collected from cases, controls and relatives of cases (including 80 families) with meticulous attention to preanalytical variables. We will identify intermediate phenotypes associated with risk of MI and its associated risk factors. Using a combination of approaches including extreme phenotype and family-based approaches we will identify variants which robustly influence these intermediate phenotypes. The genes thus identified are potential drug targets that influence risk of MI via an intermediate phenotype and are applicable across all populations. They will be validated through various approaches including computational analysis, (using Mendelian randomisation and 10 year follow-up data), and functional work that includes using zebrafish as an animal model. Machine learning algorithms will be used to analyse the multi-layered data to identify novel biomarkers and risk algorithms, including polygenic risk scores, for early risk prediction in the clinic. Quantitative targeted proteomic assays will be developed for further validation in other cohorts facilitating clinical use. Besides the increase in knowledge on the molecular etiology of MI, this powerful integrated strategy will bring rapid clinical translation of unprecedented multi-omic data.

Keywords: multi omics,genomics,transcriptomics,metabolomics,proteomics,drug targets,biomarkers,risk algorithms,myocardial infarction,atherosclerosis,risk factors,machine learning,big data
The Holographic Bootstrap (HoloBoot)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 1996250.0
EU funding (EUR): 1996250.0
Participants: 1
Project status: SIGNED

The holographic principle is believed to embody key fundamental features of any quantum gravity theory. It can be seen as a profound consequence of the intrinsic tension between the definition of quantum observables and the fact that in a theory of gravity it is impossible to define such observables in any finite volume due to the existence of Black Holes. The aim of this project is to push the boundaries of the holographic principle beyond AdS space, formulating a set of self-consistency requirements in dS, flat and inflationary backgrounds directly at the level of the sought-after holographic observables. If successful, this will allow us to understand the basic model independent principles at the basis of a quantum gravity theory and to check if a result of a calculation is consistent with unitarity and causality providing a paradigm shift in the search for consistent quantum gravity theories. The bottom-up perspective developed by HoloBoot will also be centred on phenomenological applications, ranging from classifying model-independent properties of consistent gravitational EFTs to understanding signatures of new particles during Inflation.

Keywords: holographic principle,cosmological bootstrap,flat holography,celestial cft,conformal field theory
Comparative signature of Marburg virus cell activation as a blueprint for the identification of antiviral targets against newly emerging viruses (COMBINE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Norway,Sweden,Romania,Belgium
Call: Pandemic preparedness and response: Host-pathogen interactions of infectious diseases with epidemic potential (HORIZON-HLTH-2024-DISEASE-08, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7285043.75
EU funding (EUR): 7285043.75
Participants: 7
Project status: SIGNED

Identifying cellular attachment factors and functional receptors plays a critical part in developing an understanding of a newly emerging virus. However, the identification and therapeutic targeting of plasma membrane proteins critical for virus infection is often difficult due to the transient nature of virus-cell binding and the overall kinetics of the infection process. Our goal is to interrogate virus-host cell interaction and cellular uptake of Marburg virus (MARV), a highly pathogenic and clinically relevant member of the filovirus family. To specifically target virus-plasma membrane interaction we will use a unifying inverted infection platform that allows us to halt and synchronize virus infection at the cell binding stage. Our approach is compatible with BSL-4 environment and multi-Omics technologies. It will allow us to identify the signature of virus-host cell activation, i.e., proteins involved in virus-cell entry in a tissue-specific manner. This screen will be complemented by an innovative combination of proteomics, virus-host cell interaction analysis and imaging approaches to pinpoint and characterize the involved cellular and viral proteins, their post-translational modifications and how they mechanistically concert in viral uptake. Our unique combination of different technologies will lead to the identification of viral and cellular interaction partners which will in parallel be specifically targeted by high-throughput compound screening to identify small molecules that inhibit virus-receptor interaction. Moreover, we will use our gained knowledge of tissue-specific post-translational modifications to develop improved vaccine candidates as additional prophylactic countermeasures against MARV. Our project will further deliver a blueprint experimental pipeline for the streamlined identification and antiviral targeting of proteins involved in the virus attachment process, a critical cornerstone of pandemic preparedness.

Keywords: virus entry,proteomics,small molecule screen,vaccine development,marburg virus
Rapid chip-based detection of antibiotic resistances (ResisCHIP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain,Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 165000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Drug-resistant infections are one of the greatest threats facing humanity. Antimicrobial resistance (AMR) causes over 700.000 deaths each year. Furthermore, AMR is associated to reduced quality of life, increased hospitalization periods and medical costs. Misuse and over-prescription of antibiotics for human or animal treatment are one of the drivers of AMR. At the same time, the development of new antibiotics is virtually nonexistent. Hence, developing fast diagnostic methods to identify the optimal treatment is key to effectively fight AMR and increase survival rates of patients encountering life-threatening infections. So far, diagnostics rely on bacterial cultures, leading to slow turnaround times, which are linked to the preventive administration of broad-spectrum antibiotics, often inefficient and leading to worse disease outcomes and spread of AMR. Novel approaches such as DNA PCR-based diagnostic panels or next generation sequencing methods have been recently proposed to address this issue. However, they are target a limited number of pathogens and genes or require expensive equipment and highly-trained personnel. Furthermore, they require a culture step to reach detection levels, usually lasting a few hours, that can be critical for serious conditions. Recently, using technology derived from ERC StG and PoC grants, we designed a method to concentrate, purify, and isolate bacterial RNA in just 5 minutes. Here, we seek to develop and validate these tools, combined with a rapid RNA chip array with single-molecule resolution, to provide a culture-free, fast, and highly sensitive alternative to bacterial infection diagnostics from direct blood samples. Once developed, ResisCHIP will provide a tailor-made diagnostic kit with the capacity to identify thousands of genes and pathogens from a blood sample in less than 2 hours, allowing the rapid selection of the best treatment, improving AMR stewardess, and becoming a significant breakthrough in AMR diagnostics.
Unveiling Gravitational Waves from Galactic Nuclei (GWnucleus)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

To date, the mechanisms that trigger the formation and gravitational wave (GW) coalescence of compact-object (CO, black holes, neutron stars, white dwarfs) binaries are still unknown. Two main formation scenarios have been proposed, primordial and dynamically-formed binaries, but both appear in tension with data. Galactic nuclei are a promising nursery for GW merger events, because of their high stellar density and the presence of a central massive black hole (MBH). Numerical simulations represent an ideal tool to model COs in galactic nuclei, but the current literature misses several key features which are needed to fully capture the complex physics involved. The GWnucleus project aims at filling this gap, by answering to the question: how do galactic nuclei shape the properties of gravitational waves (GW) sources? I will achieve this goal by developing an innovative hybrid Monte-Carlo/N-body model for simulating COs in galactic nuclei, at the Theoretical Astrophysics group of the Niels Bohr International Academy (NBIA), led by Prof. Martin Pessah. This novel framework will finally provide a complete understanding of GW progenitors' evolution in galactic nuclei, and establish a new theoretical model to interpret (present) and predict (forthcoming) GW observations.

Keywords: gravitational waves,galactic nuclei,few body dynamics,gravitational few body problem
HI-EURECA-PRO (HERITAGE INNOVATION IN EURECA-PRO ALLIANCE) (HI-EURECA-PRO)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Poland,Romania,Austria,Germany,Spain,Belgium
Call: European Excellence Initiative (HORIZON-WIDERA-2023-ACCESS-03, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 4299899.5
EU funding (EUR): 4299899.5
Participants: 8
Project status: SIGNED

Heritage as a source of identity, sharing, cohesion and history safeguards European values and cultivates broad European mentality of inclusiveness. This project aims to investigate the potential of heritage-based innovation for sustainable economic and social development in rural and urban communities in Poland, Greece and Romania and to identify best practices for fostering heritage-based innovation across the region and beyond (in pan-European and international collaborations). An Alliance of universities of widening (Poland, Greece and Romania) and non-widening countries (Austria, Belgium, Germany, and Spain) will develop specific measurable methods, tools and procedures for material sustainability in heritage. The main goal of the HI-EURECA-PRO project is to reach research excellence based on the heritage of regions in HEIs of three widening countries through targeted innovations supported by EURECA-PRO Alliance partners. To implement the above general goal, industrial, cultural, and mining heritage demos are planned to become Demos pilots in the actions of the project. Therefore, in accordance with the priorities and objectives of the call, the development of innovative methods, tools and processes for material sustainability in heritage will: • Create a robust regional innovation ecosystem including all parameters of the innovation quintuple helix: environmental, social, economic, political and academic • Introduce new and upskilled knowledge, which will be available to all interested parties. • Contribute to new research careers in HE with hands-on experience in involving the industry, the society and the government • open new roads for collaboration between the HEI and the market sector in the testing and application of sustainable materials, tools and methods • Will support the knowledge creation and transfer in the green and digital transition by upskilling the educational tools and methods in the green transition era

Keywords: sustainable heritage innovation mining heritage,industrial heritage,cultural heritage circular economy era agenda green deal
Advanced Manufacturing for Innovative High Temperature Heat Pump for Flexible Industrial Systems (I-UPSX)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Sweden,Poland
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 27.0
Total project cost (EUR): 451281.25
EU funding (EUR): 451281.0
Participants: 2
Project status: CLOSED

I-UPSX aims to develop and validate advanced manufacturing (AM) techniques for cost-effective subcomponents of high temperature heat pump (HTHP). These techniques and subcomponents, also complemented by a broad post-mortem assessment aim at improving cost-effectiveness, reliability, scalability, standardization and mass-manufacturing potential of high-temperature industrial heat pump fully integrated in a flexible energy system for industrial medium temperature (~400°C) heat decarbonisation (as developed and validated by I-UPS).

Keywords: advanced manufacturing high temperature heat pump heat decarbonization
Building Bridges between Earth observation and Environmental Sciences (EarthBridge)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Czechia,Germany,Italy
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1106576.25
EU funding (EUR): 1106576.0
Participants: 4
Project status: SIGNED

Unprecedented human-induced changes in climate and biodiversity are increasingly threatening nature, human life, and well-being around the world. Earth Observation (EO) has become one of the most important methods for regularly obtaining standardised information about the Earth’s environment and is therefore essential for addressing climate change, biodiversity loss, and other societal challenges. However, the full utilisation of EO is still limited. This is especially due to (1) a lack of experts in the field of EO with background in environmental sciences as well as (2) a lack of general awareness of the potential of EO in the field of environmental sciences or policy support and implementation. Universities play an essential role in bridging such knowledge and communication gaps by conducting research, developing new methods, and training new professionals. The proposed project (EarthBridge) aims to: (i) substantially increase the interdisciplinary research capacity of the Czech University of Life Sciences Prague (CZU) in the field of environmental EO; (ii) and to further improve the use of environmental EO tools by a wider community, through twinning with three internationally-leading universities: Technische Universität Dresden (TUD) and Rheinische Friedrich-Wilhelms-Universität Bonnc (UBO) in Germany, and Alma Mater Studiorum - Universitá di Bologna (UNIBO) in Italy. EarthBridge focuses on the development and application of environmental assessment methods for monitoring, restoration, and conservation of biodiversity in agricultural landscapes, a research topic of high relevance to Europe. The project will benefit from ongoing research activities that will feed into it existing EO data. Ways to achieve the bridging will include staff exchanges; scientific training and training to prepare research proposals; organisation of summer school and scoping for a joint study programme; a synthesis project for early-career researchers; and involvement of regional/national institutions according to their needs or requirements.

Keywords: earth observation,remote sensing,biodiversity,agriculture,climate,measures
Counter-acting the pandemic potential of flaviviruses: addressing virus-host interactions and defense strategies to design new therapeutics against WNV and DENV (InFlaMe)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Italy,France,Austria,Spain,Czechia
Call: Pandemic preparedness and response: Host-pathogen interactions of infectious diseases with epidemic potential (HORIZON-HLTH-2024-DISEASE-08, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 7995922.4
EU funding (EUR): 7995922.4
Participants: 11
Project status: SIGNED

To strengthen EU's ability to fight DENV and WNV epidemic and pandemic threats and elaborate effective emergency plans. The project is based on three pillars: 1) clinical investigation of host factors related to severe disease, 2) therapeutic development (i.e. host-viral protein binding inhibitors) and 3) One-Health-based surveillance of the infections. Open science practices will guarantee quality, efficiency of the research and maximise the impact of the project. The declaration of interest in the InFlaMe project of a company, world leader in the field, supports the thrustable of the network and the impact of the project’s expected outcomes. The project’s tasks will proactively be addressed in 7 sounding work packages and will go beyond the state-of-the-art. The partners have outstanding experience in all the aspects of the project, collaborated previously and working together on emerging flaviviral infections. The team includes Fondazione IRCCS Policlinico San Matteo as coordinator (IT; Fausto Baldanti), the National Institute of Molecular Genetics (IT; Renata Grifantini, Antonio Lanzavecchia and Raffaele De Francesco), Pasteur Institute (FR; Jouvenet Nolween), CIC Biogune Institute (ES; Jesus Jimenos-Barberez and Nicola Abrescia), University of Florence (IT; Cristina Nativi), Centro Nazionale per le Ricerche (IT; Giovanni Maga and Paolo Mazzetti ), Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IT; Ana Maria Moreno Martin), IMAGINE Institute (FR; Jean Laurent Casanova and Shen-Ying Zhang,), University of Vienna (AT; Judith Aberle and Karin Stiasny) and University of Masaryk (Daniel Ruzek). This truly complementary and collaborating network has a robust know-how in diagnosis of flaviviruses in humans and animals, on host-pathogen interaction and drug discovery.

Keywords: dengue,west nile,monoclonal antibodies,one health