Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Interactions between predictive coding and predictive timing in audition: characterizing the role of rhythm in repetition suppression through entrained brain oscillations (PREDICTIVECODINGTIME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-10-01
End date: 2016-09-30
Duration (months): 36.0
Total project cost (EUR): 254925.9
EU funding (EUR): 254925.9
Participants: 1
Project status: CLOSED

The present project seeks to bridge between two important lines of research in current systems neuroscience in order to enlarge our understanding of the brain’s representation of the acoustic environment. The first line investigates the neuronal mechanisms underlying auditory sensory memory trace formation. This constituted the backbone of the applicant’s PhD thesis and as well, is a major emphasis of the research group lead by Dr. Carles Escera at the return host organization of this proposal. The second line investigates the role of low-frequency neuronal oscillations tuned to environmental rhythms in dynamically shaping the excitability of neuronal ensembles, and constitutes a major topic of the research group lead by Dr. Charles Schroeder at the outgoing host organization of this proposal. In this project, both lines of research will be bridged by a series of experiments conducted in both human and nonhuman primates, aiming to unravel the neuronal mechanisms underlying the formation of internal models of the acoustic environment. In short, we seek to characterize the role of brain oscillations entrained to stimulation rhythm (Predictive Timing) in modulating neuronal adaptation to stimulus statistics (Predictive Coding) at cortical and subcortical stages of the auditory pathway, integrating information obtained at a neuronal macro-scale, observed with human electroencephalography, with that obtained at a micro-scale, observed with laminar profiles of post-synaptic potentials and neuronal spiking activity in macaques. The outcomes of this project will provide both a significant step towards understanding the predictive nature of the brain’s representation of sensory events, and new empirical bases for developing theoretical models of perception. These models will in turn, guide further human and nonhuman animal research and contribute to clinical studies on socially and economically relevant psychiatric syndromes such as schizophrenia.

Keywords: l509 systems neuroscience,l504 sensory systems,auditory,predictive coding,predictive timing,repetition suppression,brain oscillations,entrainment,ssa,rhythm,humans,macaca mulatta,eeg,mua
CO-OPTION OF THE NKG2D LYMPHOCYTE RECEPTOR AS AN ONCOPROTEIN PROMOTING CANCER STEM CELL TRANSDIFFERENTIATION AND CANCER AUTONOMY (NKG2D)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-01-01
End date: 2018-01-01
Duration (months): 36.0
Total project cost (EUR): 261326.4
EU funding (EUR): 261326.4
Participants: 1
Project status: CLOSED

The stimulatory NKG2D lymphocyte receptor expressed on natural killer cells and T cells and its tumor-associated ligands enable the immune system to recognize and destroy cancer cells. This role of NKG2D is well recognized and efforts are underway to target NKG2D and its ligands for cancer therapy. However, cancers adopt diverse strategies to safeguard their survival. With advanced human cancers, NKG2D ligand expression favors tumor progression, which has been ascribed to ligand-induced immune evasion. In a surprising conceptual twist, Dr. Spies’ laboratory at the Fred Hutchinson Cancer Research Center has found that cancer cells themselves express NKG2D together with its DAP10 signaling adaptor. Above-threshold expression of NKG2D–DAP10 in ligand-bearing tumor lines activates oncogenic signaling cascades and induces differentiation changes characteristic of the epithelial-mesenchymal transition (EMT), a cellular reprogramming process that leads to increased cancer cell motility and metastatic dissemination. Intertwined with EMT is the generation of self-renewing cancer stem cells (CSCs), which are main culprits of failed cancer therapies. These findings challenge current concepts as cancer cells may co-opt NKG2D as an oncoprotein serving their own benefit. In a preliminary assessment, this role is supported by significant correlations between proportions of cancer cells that are positive for surface NKG2D and criteria of tumor progression. This proposal seeks to establish that cancer cell NKG2D has a major role in the development of CSCs. The experimental approach involves tissue culture-based studies using model tumor cell lines and functional testing of patient-derived NKG2D bearing CSCs for their tumor forming capacity in a mouse model. The results may have profound biomedical implications by establishing a previously unrecognized mechanism that promotes tumor autonomy, and may impact translational approaches targeting NKG2D or its ligands for cancer therapy.

Keywords: natural killer group 2 member d (nkg2d),cancer stem cell,epithelial-mesenchymal transition,cancer autonomy,l406 cancer and its biological basis,l101 molecular biology and interactions
Multifunctional theranostic nanoparticles using pH-responsive DNA-nanoparticle conjugate for effective cancer therapy (NP-DNA-NDDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Cancer is a leading cause of death worldwide, accounting for 7.6 million deaths in 2008. Although conventional cancer chemotherapy can provide profound benefits, seriously adverse side-effects still cannot be avoided, due to lack of specific targeting nature of current treatments. Nanomedicine can reduce such side-effects by exploiting characteristic properties of tumors for targeted delivery and therapy. Despite extensive research, most nanomedicines developed so far have relied on passive targeting using a single therapeutic modality, which are inefficient for treatment of challenging conditions such as multi-drug resistance. Recently we developed a pH-responsive-DNA-GNP conjugate based nanocarrier that numerous features required for an ideal drug nanocarrier, e.g. uniform small nanoscale size, resisting non-specific adsorption, non-toxic, biocompatible, water-soluble, stable, and having high drug loading and controlled release capacities. It can offer efficient and pH-triggered drug release suitable for effective cancer chemotherapy at the cellular level using doxorubicin, a widely used chemotherapy drug. Herein we will extend it into a more effective, multifunctional nanomedicine that can offer simultaneous biomodal chemotherapies with hyperthermia and MRI imaging capacities. First, we will prepare, characterize, and evaluate their drug loading & release profiles in buffer; then we will study and quantify their cell- & cell-specific- uptake and drug delivery efficiency, and then evaluate their toxicity, cytotoxicity & cell-specific cytotoxicity with cancer cells (incoming phase), and finally evaluate their synergistic therapeutic efficacy at cellular and preclinical level (re-integration phase). This project will greatly benefit both the fundamental research in nanomedicine and the healthcare/pharmaceutical indurstries in Europe.

Keywords: nanochemistry,nanomedicine,nanoparticle,dna nanotechnology,cancer therapy
Proximity Enhanced Energy Harvesting of Multi-Axis Motion (PROXEE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Proximity Enhanced Energy harvesting of multi-axis motion (ProxEE) is a proposal to design, model, fabricate and test a class of inertial micro energy harvesters that convert multidimensional and non-periodic human motion into electrical energy for powering body worn and medical devices. The harvester uses a spring-less spherical magnetic proof mass to capture kinetic energy from the user, after which an array of transducer ‘cells’ employing a novel actuation method are used to convert the mechanical energy into electricity. The contactless actuation mechanism uses magnetic attraction between the proof mass and a magnetic fluid to induce an aspect change in a variable capacitor thereby allowing the coupled energy to be transduced using electrostatic means. A hydraulic amplification scheme is utilized to produce a mechanical advantage and to increase the force in the electrostatic transducer. The mobility proposed in this project is for the fellow, an expert in the field of energy harvesting and microsystems technology, to expand his skill set and research portfolio while working on a novel project at the University of Freiburg Department of Microsystems (IMTEK) in Germany. This project couples together the fellow’s expertise in developing low-frequency wide bandwidth motional energy harvesters with the host’s mastery in the development of microsystems technologies, materials testing, and mechanical design. This project will have a strong impact on the European Research Area (ERA) through the innovative project and associated knowledge creation, focused knowledge transfer and a new international collaboration, training of students, and outreach.

Keywords: g313 micro(system) engineering,g202 electrical and electronic engineering,electromechanical engineering,energy harvesting,vibration harvesting,mems,motion harvesting
The molecular network linking nitrogen assimilation to growth (NITROSIGN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-07
End date: 2015-05-06
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The high yield of crop plants currently supports the global population with sufficient food, but this is achieved at substantial environmental cost. One of the most significant of these costs involves the use of nitrate fertilizers, which pollute groundwater supplies and promotes the formation of a potent greenhouse gas. The aim of this project is to understand in more detail the efficiency of soil nitrate use at the molecular level using the wealth of knowledge, tools and resources available in Arabidopsis. The research plan is based on work in the host laboratory showing a genetic link between the amounts of available photosynthate, nitrate transporter gene expression, nitrate uptake and growth. Physiologically this involves the plant balancing nitrate acquisition from the soil with carbon metabolites for amino acid biosynthesis. This balance directly influences growth in response to nitrate and is a potential control point. However, the molecular mechanisms need to be understood in more detail in order that the knowledge can be used to breed new crop varieties that use nitrate more efficiently. The project involves a genetic screen to identify genes that influence the levels and activity of key nitrate transporter in response to available sugar. Another screen of transcription factors that bind to and activate the transporter gene will also be conducted. Together these will identify new components in the regulatory circuit controlling nitrate uptake and utilization. The researcher brings highly complementary expertise in sugar signaling from Utrecht to the John Innes Centre that is essential for the success of the project. Her skills will be augmented by a training programme to impart additional skills, knowledge and experience required for her future career as an independent scientist. Importantly, exposure to industry and public engagement activities will help develop a well-rounded, productive and skilled researcher.

Keywords: molecular regulatory components,nitrogen assimilation,nitrate transporter,growth,next generation mapping,gene expression regulation,genetic screening,crop,enviroment
Development of Low Band Gap Conjugated Polymers by EcoFriendly Synthetic Methodologies for High Performance Organic Photovoltaics (ECOCHEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Novel low band gap (LBG) conjugated polymers and state-of-the-art electron donor polymeric materials used in high performance organic photovoltaics (OPVs) will be developed with the aim to replace existing hazardous ones for cleaner and environmentally friendly laboratory and industrial processes. Direct Arylation (DAr) represents an economically attractive and ecologically benign alternative to the traditional cross-coupling methodologies (Suzuki and Stille; Nobel Prize in Chemistry 2010). Despite the great versatility and choices in Suzuki and Stille cross-couplings, these reactions have drawbacks such as numerous steps to monomer synthesis, instability of the organometallic reagents, and formation of stoichiometric amounts of toxic by-products, preventing their easy scale-up manufacturing. Easy large scale production of organic semiconductors by eco-friendly procedure (DAr) and their applications platforms entails robust, non-cleanroom, low-cost infrastructure along with affordable, environmentally benign materials, ideal for globally competitive production by local SMEs and large enterprises. Finally, advanced spectroscopic characterization and photovoltaic evaluation will be performed on the new polymers and blends thereof with fullerene derivatives in order to identify the elementary mechanisms that govern the fundamental physicochemical processes. As a proof of concept, solar cell fabrication and optimization will be performed on the most promising systems with the goal to achieve world class power conversion efficiencies (PCEs) above 9.0%.

Keywords: polymer chemistry,organic chemistry,physical chemistry,molecular architecture and structure,environmental toxicology,photochemistry,thin films,semiconductors,molecular electronics
Impacts of metallurgy: iron production and the environment in the Pare Mountains, Tanzania (ENVIRON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-04-22
End date: 2015-07-21
Duration (months): 27.0
Total project cost (EUR): 218151.82
EU funding (EUR): 218151.82
Participants: 1
Project status: CLOSED

The advent of metallurgy was one of the most important transformations in human history, widely considered to have driven political, social, economic and environmental change. The ability to produce metal tools and weapons is said to have instigated shifts in both physical and cultural landscapes, facilitating the expansion of agriculture, encouraging the growth of urban centres, and advancing the rise of complex political systems. Knowledge and control of these transformative technologies is frequently seen as a cornerstone in the early acquisition of material wealth, physical might and symbolic authority. However, the intensification of iron production is also often attributed with triggering pronounced ecological deterioration, whether in the forests of Europe, Asia, the Americas or Africa, due to an increased need for fuel and a subsequent over-exploitation of wood resources. Despite the frequency with which this argument is referenced, it is a hypothesis that remains to be systematically tested. Yet the importance of developing a firm understanding of this relationship is not to be overlooked. Through an exploration of the links between past industries and historical environmental change, more coherent strategies for resilient resource exploitation in the present can be developed, in Africa and elsewhere. An archaeological study of iron production in the Pare Mountains, Tanzania presents an excellent opportunity to do just this. Within a defined research area, the fuel needs of an emergent iron industry can be quantified and mapped through time. By examining this data in conjunction with highly comprehensive extant environmental records from the region, and through a consideration of the social organisation of local communities, the impact of metallurgy within this landscape can be characterised, with wide-reaching ramifications for the understanding of human-environment interactions on a global scale.

Keywords: soc iron technology environment deforestation
Applying neuroscience to social policy and the law: neuromaturation and young adult offending (NEUROSCISOCPOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-10-01
End date: 2016-09-30
Duration (months): 36.0
Total project cost (EUR): 388538.6
EU funding (EUR): 388538.6
Participants: 1
Project status: CLOSED

This proposal is concerned with the complex and contested application of emerging understandings within neuroscience to issues of law and social policy, with a focus on young adults in the criminal justice system, including those with neurodevelopmental difficulties. The last 30 years have seen remarkable advances in the range of neurosciences. The application of these advances to a wide range of legal and social policy concerns is clear, though also controversial and potentially problematic. The fellowship has three objectives: to facilitate multidisciplinary debate regarding the challenges and possibilities in the application of neuroscience to social policy; to consider the explanations apparent in emerging understandings of neuromaturation of patterns of offending behaviour amongst young adults; and to explore the implications of these emerging understandings for policy and practice within the criminal justice system. The fellowship provides an opportunity for a social policy academic with significant experience researching criminal justice policy and practice to be based in the Murdoch Childrens Research Institute: the preeminent child health research organisation in Australia, recognised globally for its research in neurodevelopment and adolescent health. Under expert supervision, the applicant will review existing neuroscience and associated research, addressing its application to law and social policy, and undertake secondary analysis of longitudinal quantitative survey and neuroimaging data to develop indicators of neurodevelopment applicable to understandings of offending. This will facilitate interdisciplinary debate through a series of workshops engaging policymakers and practitioners, followed by two empirical studies critically exploring current approaches to assessment and intervention. The return phase will enable comparative empirical work, allowing consideration to the potential impact of neuroscience in two highly varied criminal justice systems.

Keywords: s114 social studies of science and technology,s110 legal systems - constitutions - foundations of law,l511 neurological disorders
Physiological mechanisms underlying interpersonal coordination and observation in joint action (PHYSIO COUPLING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 138475.2
EU funding (EUR): 138475.2
Participants: 1
Project status: CLOSED

Interpersonal coordination and observation are crucial to social interactions, whether we are engaging in conversation with other people, jointly assembling furniture, or performing in a musical duet. Previous research in social cognition has so far been mostly restricted to measuring behaviour and brain signatures of isolated individuals, in the absence of a real interaction. There has been a recent movement in the field, away from individuals in isolation and towards a joint action approach, employing studies of two or more individuals engaged in an interaction. Interpersonal mechanisms of joint action have largely been addressed by studying behavioural synchronization between people’s movements, gazes, and postures as they engage in real-time, joint, rhythmic actions. Recent studies have also begun to investigate physiological synchronization between romantic partners, choir singers, and performers and observers during high arousal rituals. However, the physiological mechanisms underlying joint action remain largely unknown, and their relationship to action coordination and observation has not yet been established. Here, we propose to investigate the relationship between interpersonal behavioural and physiological coupling at the autonomic nervous system level, during observation and participation in joint coordination. The first objective of the proposed project is to investigate the relationship between behavioural coupling and physiological coupling, during coordinated action in a musical setting. The second objective is to investigate physiological coupling between performers and observers of behavioural synchronization in online and offline scenarios. Finally, the third objective is to investigate the effect of physiological coupling, enabled using biofeedback training, on behavioural synchronization. This research takes a novel direction towards understanding coordination and human bonding beyond behaviour and brain activity.

Keywords: interpersonal coordination,physiological coupling,joint action,biofeedback training