Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ToWards Immunisations that Last: the Immunology and Gerontology of Helper T cells (TWILIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 1499997.95
EU funding (EUR): 1499997.95
Participants: 1
Project status: CLOSED

A major accomplishment of modern society is the extension of human life expectancy. However, this creates a new challenge for medical science, to facilitate healthy ageing. With age, the function of the immune system declines, rendering older people more susceptible to infections and less able to benefit from vaccination. Indeed, improving vaccine efficacy is key to reducing infection-related morbidity in older people. To date, the complexity of the ageing process has hindered attempts to fulfil this ambition, and thus innovative approaches are required to better understand the underlying biology. Vaccination creates protective immunity by inducing the germinal centre (GC) response, an intricate process that generates memory B cells and long-lived antibody-secreting plasma cells. However, the GC response declines with age. Strikingly, it is not B cells that are responsible for the age-dependent decline in the GC response, but the CD4+ T cells and the microenvironment of older individuals. The cellular and molecular mechanisms responsible, however, remain unknown. In the GC there are two subsets of specialised CD4+ T cells, T follicular helper (Tfh) and T follicular regulatory (Tfr) cells, which act in opposition to promote and suppress the response, respectively. I hypothesise that aberrant formation and/or function of Tfh and Tfr cells contribute to impaired GC responses during ageing, and that these cells could be targeted to improve vaccine efficacy. Furthermore, the most prominent age-dependent change in secondary lymphoid tissues is the accumulation of senescent cells, which can modify immune function and tissue structure. I hypothesise that accumulation of senescent cells alters this microenvironment, impairing the response to vaccination. I will test these hypotheses using new mouse models and innovative approaches to human research, in the expectation that the knowledge obtained will promote healthy ageing and uncover novel aspects of GC biology.

Keywords: germinal centre,t follicular helper cells,t follicular regulatory cells,vaccination
Mediators in plant pathogenic fungal-bacterial symbiosis (FUNBIOSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Interspecies interactions between fungi and bacteria are highly prevalent in nature and are critically important in a variety of fields including agriculture, food processing, biotechnology, medicine, and dentistry. The study of such bacterial-fungal interactions (BFIs) can provide invaluable information regarding host-pathogen interactions that can be leveraged in understanding and treating important animal and plant diseases. The unique experimental tractability of the Rhizopus-Burkholderia endosymbiosis provides a model system for the investigation of the secreted factors central to BFIs. One remarkable feature in BFIs is the delivery of bacterial effector molecules that can take control of their eukaryotic host cell. FUNBIOSIS aims to speed up the discovery of natural compounds utilised by endosymbiotic Burkholderia sp. to control its fungal host by integrating the emerging technology of microfluidics. We will focus on novel effector molecules that: (i) can modulate host gene transcription (transcription activator-like effectors, TALEs); (ii) are associated with the recently discovered type 6 secretion system (T6SS); and (iii) are involved in chromatin-dependent changes in the host genome. This will not only elucidate the nature of host control in this commercially important BFI but also has the potential to serve as a roadmap to understanding how prokaryotic pathogens and symbionts interact with more complex eukaryotic hosts. Understanding the biology, ecology, and biotrophic interactions of the zygomycetes (of which Rhizopus microsporus is a member) with their associated endobacteria can help to identify novel secondary metabolites which are central to ecological functions and are useful for effective and innovative biotechnological utilisations.

Keywords: bacterial fungal interactions,endosymbiosis,host control,tal effectors,type 6 secretion system,epigenetics,host gene regulation,microfluidics,proteomics,genetic engineering,analytical chem
Development of an innovative alternative to the use of hexavalent chromium in the aerospace coating (Cr VI FREE COATING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aerospace coatings industry has been working to minimise the exposure of individuals with the sector from Carcinogenic Mutagenic Reprotoxic (CMR) compounds such as hexavalent chromate based coating solution. The drive has been steered towards substituting or at least limit to the bare minimum CMR compounds according to European Directive 2006/122/EC and the European Registration Inspection (REACH) requirements. As Mapaero SAS, a French manufacturer of water based aerospace paints and coating products, we have developed turnkey innovations for the aerospace coatings sector. We have developed a water based primer P7X that is free of the CMR classified hexavalent chromate corrosion inhibitor base in compliance to the Directive 2006/122/EC and REACH requirements. Since our primer is chromate free, we have also developed an effectiveness assessment test Droplet Test, used together with the conventional Salt Spray Test. Our innovation will result in a quick drying, chromate free water based primer that can be easily sprayed onto large aerospace parts with a long pot life >4hours and reduced Volatile Organic Compounds (VOC) constituent limited to <350g/L. Our Droplet test will reduce primer effectiveness validation test from 3,000hours to 168hours. We anticipate this will inevitably result in the establishment of a new standard in the effectiveness assessment of chromate free aerospace coating solutions. The main objective of this Feasibility Study is to initiate and validate the primer qualification for commercial development according to aerospace regulations and define the best strategy to reach market readiness. As a result of this project, we anticipate that we will grow our turnover of €20.82 million and a profit of €12.22 million, increase the headcount by 40 and achieve a ROI of 71,46% for each invested Euro by 2025.

Keywords: hexavalent chromate,aerospace primer,chromate free corrosion inhibitors,water based primer,aerospace coatings,carcinogenic mutagenic reprotoxic cmr
Antibiotic Resistance: Socio-Economic Determinants and the Role of Information and Salience in Treatment Choice (ABRSEIST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Germany,Denmark
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1498920.0
EU funding (EUR): 903996.25
Participants: 2
Project status: SIGNED

Antibiotics have contributed to a tremendous increase in human well-being, saving many millions of lives. However, antibiotics become obsolete the more they are used as selection pressure promotes the development of resistant bacteria. The World Health Organization has proclaimed antibiotic resistance as a major global threat to public health. Today, 700,000 deaths per year are due to untreatable infections. To win the battle against antibiotic resistance, new policies affecting the supply and demand of existing and new drugs must be designed. I propose new research to identify and evaluate feasible and effective demand-side policy interventions targeting the relevant decision makers: physicians and patients. ABRSEIST will make use of a broad econometric toolset to identify mechanisms linking antibiotic resistance and consumption exploiting a unique combination of physician-patient-level antibiotic resistance, treatment, and socio-economic data. Using machine learning methods adapted for causal inference, theory-driven structural econometric analysis, and randomization in the field it will provide rigorous evidence on effective intervention designs. This research will improve our understanding of how prescribing, resistance, and the effect of antibiotic use on resistance, are distributed in the general population which has important implications for the design of targeted interventions. It will then estimate a structural model of general practitioners’ acquisition and use of information under uncertainty about resistance in prescription choice, allowing counterfactual analysis of information-improving policies such as mandatory diagnostic testing. The large-scale and structural econometric analyses allow flexible identification of physician heterogeneity, which ABRSEIST will exploit to design and evaluate targeted, randomized information nudges in the field. The result will be improved rational use and a toolset applicable in contexts of antibiotic prescribing.

Keywords: health economics,pharmaceutical demand,bayesian learning,machine learning,structural modeling,field experimentation
MOXO-Mobile: the first Attention Deficit Hyperactive Disorder (ADHD) screening mobile application, using Eye Tracking and Continuous Performance Test components to give the first evidence of attention (MOXO-Mobile Phase-1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Undiagnosed ADHD leads to learning and social difficulties, school drop-out, unemployment, criminality, and even premature death. Early diagnosis can dramatically improve the quality of life of at least 26 million individuals in the EU, prevent incarceration and recidivism, and save lives. MOXO-Mobile is the first ADHD screening mobile application, combining a Continuous Performance Test (CPT) and Eye Tracking (ET) to give an accurate and simple evaluation of the evidence of attentional difficulties. Using this application, every smartphone user could assess his/her attention level and profile and receive further guidance, in case of need, for further diagnosis. The application will be downloaded for free with pay-per-use strategy as the user will purchase tests as he wishes for himself and his family. MOXO-Mobile will create a new market (ADHD screening), with max market potential of €2.8B, and a projected ROI of 6.1 in 3 years for MOXO-Mobile. SMEi Phase 1 will enable Neurotech-Solutions to conduct a wide feasibility study, establish an elaborated business plan, risk assessment, and a sustainability estimation of the product.

Keywords: adhd,digital health,mass population screening,medical service accessibility,early detection,pre diagnosis
Enabling a Mobility Back-End as a Robust Service (EMBERS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Germany,France,France,France,Portugal
Call: Integrating experiments and facilities in FIRE+ (H2020-ICT-2015, 2015)
Start date: 2015-12-01
End date: 2018-11-30
Duration (months): 36.0
Total project cost (EUR): 2156837.5
EU funding (EUR): 1999525.0
Participants: 8
Project status: CLOSED

EMBERS will bring to market a back-end for smart city mobility that is developed by a European small enterprise based upon its smart parking and smart traffic management products that two municipalities in Portugal currently deploy. The Mobility Back-end as a Service (MBaaS) replaces such all-in-one systems, in which a municipality purchases the full set of components from a single vendor. Instead, the city manager can purchase best-of-breed devices and apps developed by third parties, with the only constraint being that they interoperate with the back-end via a free, open, smart city mobility API. This domain-specific API lowers barriers to entry for app and device developers, making it easier for innovative SMEs to enter the market. Furthermore, the API is offered via a variety of generic interfaces, including oneM2M, ETSI M2M, OMA LWM2M, and FIWARE NGSI. EMBERS thus clears the way for developers and to municipalities that have adopted any one of these potential emerging machine-to-machine (M2M) communication standards. Beyond its primary goal of bringing the MBaaS to market, EMBERS will stimulate development of an entire ecosystem around the MBaaS smart city mobility API. Separating out the back-end from the other components will, however, require rigorous testing. EMBERS will experiment with the system on two testbeds that are part of the FIRE+ OneLab facility: the FUSECO Playground, for M2M communications, and FIT IoT-LAB, for wireless sensor devices. EMBERS will host a hackathon and an app challenge to bring in third party developers. The project will also include three demonstrators by third parties via an open call. These activities will contribute back to FIRE+ by demonstrating successful experimentation by SMEs developing close-to-market products. The project will also conduct real world pilots in two or more cities as a final step in bringing the MBaaS to market.

Keywords: internet of things,smart cities,open innovation,cloud services,intelligent transportation services its,sensor networks
Ultrashort Pulse Generation from Terahertz Quantum Cascade Lasers (ULTRAQCL)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,France,France,United Kingdom
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2014)
Start date: 2015-10-01
End date: 2019-03-31
Duration (months): 42.0
Total project cost (EUR): 2798445.0
EU funding (EUR): 2798445.0
Participants: 5
Project status: CLOSED

The generation of ultrafast and intense light pulses is an underpinning technology across the electromagnetic spectrum enabling the study of fundamental light-matter interactions, as well as industrial exploitation in a plethora of applications across the physical, chemical and biological sciences. A benchmark system for such studies is the modelocked Ti:Sapphire laser, which has grown from being a laboratory curiosity to an essential tool in a broad range of application sectors. Beyond Ti:Sapphire systems, there have been impressive developments in semiconductor based devices for pulse generation in the optical range. These benefit from low system costs and are an enabling technology in new application domains including high speed communications. However, in the terahertz (THz) frequency range, with its proven applications in imaging, metrology and non-destructive testing, a semiconductor based technology platform for intense and short pulse generation has yet to be realised. Ultrafast excitation of photoconductive switches or nonlinear crystals offer only low powers, low frequency modulation or broadband emission with little control of the spectral bandwidth. In the ULTRAQCL project we will breakthrough this technological gap, using THz quantum cascade lasers (QCLs) as a foundational semiconductor device for generating intense and short THz pulses. QCLs are the only practical semiconductor system that offer gain at THz frequencies, hence making them suitable for pulse generation, with the ‘bandstructure-by-design’ nature of QCLs allowing the frequency, bandwidth and pulse width to be entirely engineered. We will demonstrate: the first self-starting (passive) mode-locked THz QCL; the first hybrid modelocked THz QCL; the first gain-switched modelocked QCL; and, the first pulse generation in QCLs with on-chip dispersion compensation. The ULTRAQCL project will implement these radical schemes for pulse generation enabling ultrafast QCLs to become a ubiquitous technology for the THz range.

Keywords: terahertz,modelocking,quantum cascade lasers
Multichannel Investigation of Solar Modulation Effects in Galactic Cosmic Rays (MAtISSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-05
End date: 2018-05-04
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The topic of the MAtISSE project is the Multichannel Investigation of Solar Modulation Effects in Galactic Cosmic Rays (CRs). When entering the heliosphere, CRs encounter a turbulent flowing plasma, the solar wind, which modulates their energy spectra. The solar modulation is expected to be different for positive and negative particles (due to charge-sign dependent effects) or for leptons and nuclei (due to different charge/mass ratios), making their individual studies essential. The study of these effects has been limited for long time by two factors: the scarcity of long-term CR data, and the poor knowledge of the interstellar spectra. With the Alpha Magnetic Spectrometer (AMS) in continuous operation on the International Space Station (ISS), we have now an excellent multichannel CR monitor of solar activity. With the spectacular Voyager-1’s entry in the interstellar space, we have the very first data of CR fluxes unaffected by solar modulation. The aim of this project is two-fold: (i) to extend solar modulation measurements of CR leptons and nuclei using the AMS data from the ISS, and (ii) to develop a numerical model of CR modulation to be characterised by new data from AMS, spacecrafts and ground detectors. With the unprecedent quality of new data, this project is aimed to achieve strong theoretical and observational milestones. By advancing observations of particles and antiparticles, we will explore the origin of CRs and their propagation in the Galaxy. By numerically modelling the solar modulation, we will study their fundamental transport processes in the heliosphere. The goal of this project is to provide a detailed measurement-validated model of modulated CR fluxes at all locations on Earth for varying solar activity conditions. This goal addresses a prerequisite for modelling the effects of cosmic radiation and space weather hazards, which is an increasing concern for space missions and air travellers.

Keywords: cosmic rays,solar modulation,heliophysics,heliosphere,data analysis,particle astrophysics
Friction Welded Valve for Enhanced Hygiene in Food and Beverage Industry (FricWeld)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-11-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Aviatec aims to pursue a major market opportunity through testing and demonstrating a new cost-effective sanitary valve housing for the food and beverage processing (F&BP) industry, where hygiene is of utmost importance. The novel valve housing is fully assembled using friction welding (FW), achieving the highest level of hygiene. The primary benefits for equipment manufacturers and end-users are stemming from significant savings in materials and energy, as well as increased food and beverage safety: • Very hygienic and easy-to-clean solution: it ensures 100% elimination of pores, cracks and other unhygienic hiding places for bacteria formation, and facilitates clean-in-place (CIP) activities. • Savings on material and energy, reduced labour costs and processing time: the process is accomplished without the use of filler metals, fluxes or shielding gases, therefore no consumables are needed and no waste is generated. It minimizes energy and raw material consumption. It produces no fumes, gases or smoke and is a fast process. • Process flexibility: by combining different materials and dimensions, material costs are reduced without compromising on strength, and new products/equipment may be introduced because the design becomes more flexible. Additionally the process offers 100% traceability. Despite these advantages, the technology still has not achieved a breakthrough in this market, mainly because of conservatism and scepticism towards new equipment, as well as a general lack of knowledge about the possibilities of FW in F&BP market. In this scenario, and leveraging on a large accumulated know-how, Aviatec wishes, in the FricWeld Phase 1, to detail the viability of offering the novel valve housing for the F&BP industry. Subsequently in FricWeld Phase 2, ensuring and demonstrating a maximum level of hygiene, as well as lower costs and environmental impact, will be a key differentiating factor to gain access to the market.

Keywords: food and beverage safety,food and beverage processing industry,hygiene,sanitary valve,welding