Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Research to Reality: Digital Solutions to European Challenges (DIGITAL-HE BEPCY24)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Coordination and support actions
Countries involved: Belgium
Call: ICT Event 2024 (HORIZON-CL4-2023-ICT-EVENT-2024, 2023)
Start date: 2023-06-01
End date: 2024-04-30
Duration (months): 11.0
Total project cost (EUR): 630624.38
EU funding (EUR): 500000.0
Participants: 3
Project status: CLOSED

The event, organised by the Belgian regions represented by the Department EWI from the Flemish Government, Innoviris from the Brussels capital region government, and SPW Economie from the Walloon government, aims to bring together researchers involved in research on digital technologies within the Horizon Europe programme, implementers involved in projects from the Digital Europe Programme, and policy makers working on digital policy at regional, national, and European levels. The primary goal is to discuss policy and practical challenges hindering cooperation between the two framework programmes, particularly in terms of digitalisation. To ensure diverse perspectives, there is a strong emphasis on making this event interactive. Other objectives include fostering networking among different target groups, reviewing the functioning of the Digital Europe Programme, and providing a platform to showcase best practices in cooperation and synergy between the two framework programmes. The event is scheduled for the 5th of February 2024 in Brussels, with visits to relevant organisations in Belgium planned for the following day. Overall, the event aims to create a dynamic platform where researchers, implementers, policy contributors, and other stakeholders can converge, exchange ideas, and contribute to the advancement of digitalisation initiatives in Europe.

Keywords: digitalisation,research,digital europe programme,horizon europe,digital,synergy,policy,europe,europe s digital decade,strategic autonomy
Towards an understanding of social media: The effects on health, well-being, and genetic susceptibilities (SOCIAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: SIGNED

In 2022, 63% of the world population actively used social media, spending a daily average of 2 hours and 27 minutes on these platforms. Despite its widespread adoption, our understanding of social media's impact on health and well-being remains limited, mostly due to lack of data availability on social media use. SOCIAL leverages several unique data sets and takes a comprehensive approach to investigate the effects and susceptibilities associated with social media use. This knowledge is fundamental to design smart and effective regulations that promote promote individual well-being in an era of rapid digital evolution. This proposal introduces a novel perspective to social media research. It aims to study the 2021 Facebook papers leak, the 2022 TikTok ban on government devices, Instagram's transition to an algorithmic feed in 2016, and the 2024 EU Digital Services Act, examining their impact on social media users. Additionally, it investigates the genetic factors influencing social media usage patterns, utilizing molecular genetic data and a within-family design to explore whether genetic susceptibilities to mental disorders contribute to social media use patterns. This action, unfolding at Nova SBE in Portugal under Prof. Pedro Pita Barros' guidance and Cátia Batista collaboration, addresses research questions, offers training and career development, and greatly enhances skills and fosters my career prospects. By joining Nova SBE, I'll broaden my network, fortify capabilities, and leverage my expertise in health economics, econometrics, and social-science genetics to expand their research capacity.

Keywords: health economics social media mental health genetic susceptibilities social science gentics impact evaluation natural experiments
Development of a novel hiPSCs-derived Vascularized-Epicardial-Adipose-Tissue-on-Chip model to investigate cellular crosstalk in healthy and stressed states (VEAT-ChiP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Obesity-associated metabolic and cardiovascular diseases (CVDs) are serious public health concerns. A fat depot surrounding the heart, known as epicardial adipose tissue (EAT), is likely contributing to the pathologic conditions leading to CVDs. But it might also play a protective role during ischaemic events highlighting a complex role of EAT in heart homeostasis and disease. Some studies report post-menopausal women having an increased EAT suggesting that changes in levels of of sex hormones affect EAT and may cause sex-specific contributions to metabolic diseases. Though EAT covers nearly 80% of a human heart, it is virtually absent in rodents. Given the underexplored role of EAT in the pathology of CVDs, and the lack of animal models, human in vitro cardiovascular EAT model is necessary. VEAT-chip proposes to develop the first human induced pluripotent stem cells (hiPSCs) derived, fully autologous, vascularized EAT-on-chip model. The project will start with establishing a novel protocol to obtain epicardial adipocytes. Then, those cells will be integrated into hiPSCs derived cardiac-specific vessels-on-chip to generate a vascularized EAT-on-chip. Given an undetermined role of sex hormones for EAT function and an unclear balance of protective and toxic effects of EAT in pathological settings, vEAT-chip will explore hormone- induced changes in function of EAT during homeostasis and stressed conditions. In a final aim of the project, addition of cardiomyocytes (CMs) to the system will result in a model resembling a portion of the heart wall. By combining novel hiPSCs differentiation protocols, organ-on-a-chip technologies, advanced microscopy techniques, and global transcriptome and secretome analysis, the VEAT-chip project will reveal EAT-associated factors affecting healthy function of cardiac-specific vessels and CMs. Ultimately, VEAT-chip will provide a novel means to study cellular crosstalk and unravel mechanisms associated with cardiometabolic diseases.

Keywords: organ on a chip,epicardial adipose tissue,human induced pluripotent stem cells,vascularised in vitro tissues,sex hormones
Science PlAtform Cloud Infrastructure for Outsize Usage Scenarios (SPACIOUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Spain,Portugal,United Kingdom,Poland
Call: Scientific exploitation of space data (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1511755.0
EU funding (EUR): 1511755.0
Participants: 7
Project status: SIGNED

The SPACIOUS project aims to boost the scientific exploitation of ESA mission data by offering a new computational framework for astrophysical research that requires Big Data and Data Mining technologies to be employed. SPACIOUS will raise the competitiveness of the EU scientific community by increasing the Big Data and Data Mining expertise and providing easier access to these techniques. To reach this goal SPACIOUS aims to combine existing technologies in a new Data Mining environment to enable the analysis of ESA missions’ data up to a level which is not possible without a dedicated infrastructure. The ambition of SPACIOUS is to open this platform to the community, while at the same time exploiting the data by developing astrophysical research, in collaboration with external scientific teams. The main idea is to facilitate and open the analysis of ESA archives to the scientific community in new ways. SPACIOUS will make the difference by providing access to the data and, at the same time, providing the infrastructure, tools and methods to analyse these data. SPACIOUS will be the tool enabling Big Data analysis of ESA data products. Furthermore, we expect SPACIOUS to make a change by influencing the future way to treat data in space science. A key part of the project is to produce scientific value (publications, enhanced data products and knowledge). We will face major scientific research data problems (challenges) whose analysis will be, per se, a key result of SPACIOUS. Four of these challenges will be defined internally (based on the exploitation of the massive Gaia and Euclid datasets) and used to drive the design requirements of the system, serving as test cases and technology demonstrators of the Big Data Analytics Framework (BDAF). In a second phase we will open the system to the community through an Open Call for proposals and will select the most relevant (both scientifically and technically) challenges submitted for their implementation.

Keywords: data mining,big data,cloud computing,cosmology,astrophysics,the milky way
Generation of cartilage-free kidney organoids: a small molecule strategy (GECKO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

The prevalence of chronic kidney disease in Europe varies from 3.3–17.3% and has risen during the last decades. In the world, 9.7 million people need kidney replacement therapy, but only 2.6 million will receive it. These numbers are expected to double within the next 10 years, increasing the pressure to find alternative solutions. Recent scientific developments to generate kidney organoids in vitro have opened the possibility for a regenerative medicine–based approach that would provide a functional substitute to the failing kidney. These kidney organoids can recapitulate renal structures as well as the cellular complexity of human kidney, and may restore glomerular filtration upon transplantation. In this project, we make use of human induced pluripotent stem cells that can be differentiated with a cocktail of biomolecules and aggregated to form of kidney organoids that are cultured at the air–liquid interface. This protocol leads to the formation of complex renal structures including glomeruli and tubules. While kidney organoids show great therapeutic potential, they also present several drawbacks, one of which is the appearance of off-target cell populations, such as neurons, myocytes and chondrocytes within the organoid. Preventing the appearance of these off-target cells will greatly improve the quality of the organoids. Preventing cartilage formation is most desirable because cartilage completely disrupts the organoids and renders them dysfunctional and unsuitable for in vivo use. The reasons for the consistent observation of chondrocytes during organoid growth and transplantation are not yet understood. The objective of this work is to understand the molecular mechanisms of cartilage formation in kidney organoids and reduce it using a small molecule strategy.

Keywords: kidney organoids,cartilage,regenerative medicine,small molecule strategy
ORGANIC FARMING INNOVATIONS NETWORK EUROPE (OH-FINE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Poland,Bulgaria,Lithuania,Austria,Belgium,Switzerland,Italy
Call: Organic farming thematic networks to compile and share knowledge ready for practice (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 4038396.56
EU funding (EUR): 3823271.8
Participants: 18
Project status: SIGNED

Oh-FINE´s is a 48-month long project that aim to empower European farmers and smallholders through the definition, enhancement and transfer of competitive and efficient organic farming knowledge and alternatives that address farmer’s capacities, consumer needs and evolving food market changes. To this end Oh-FINE will create pan-European Organic Farming Learning Community (OFC) structured in four main technological pillars: 1) to develop a multidimensional framework on the organic farming knowledge and practices; 2) to establish a multi-agent approach organic farming learning system and validate the framework in 5 case of studies areas across Europe, 3) to collect distribute and disseminate to farmers and other stakeholders of easily accessible practice-oriented knowledge focusing on organic farming and covering cereals, oilseeds, protein crops, and livestock, and 4) to develop a Decision Support System ICT Tool for farmers.

Keywords: farming learning community,conversion knowledge exchange thematic network multi actor innovation akis cooperation co creation cross fertilisation dissemination spreading of organic farming empowering farmers
Extreme-scale Urban Mobility Data Analytics as a Service (EMERALDS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Countries involved: Greece,Austria,Italy,Spain,Netherlands,Latvia,United Kingdom,Belgium,Germany
Call: Extreme data mining, aggregation and analytics technologies and solutions (RIA) (HORIZON-CL4-2022-DATA-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 4998938.0
EU funding (EUR): 4998438.0
Participants: 23
Project status: SIGNED

EMERALDS’s vision is to design, develop and create an urban data-oriented Mobility Analytics as a Service (MAaaS) toolset, consisting of the so-called ‘emeralds’ services, compiled in a proof-of-concept prototype, capable of exploiting the untapped potential of extreme urban mobility data. The toolset will enable the stakeholders of the urban mobility ecosystem to collect and manage ubiquitous spatio-temporal data of high-volume, high-velocity and of high-variety, analyse them both in online and offline settings, import them to real-time responsive AI/ML algorithms and visualize results in interactive dashboards, whilst implementing privacy preservation techniques at all data modalities and at all levels of its architecture. The toolset will offer advanced capabilities in data mining (searching and processing) of large amounts and varieties of urban mobility data and its efficiency will be assessed, validated and demonstrated in three TRL5 pilot use cases (by following a co-development approach with mobility and city stakeholders to improve decision making in urban smart city environments), and deployed/showcased in two early adopters’ data-driven TRL6 applications (by integrating the new services to existing systems to improve commercial offerings).

Keywords: extreme scale urban mobility data analytics,analytics as a service,maaas
What doesn’t kill you: primed and adaptive mechanisms of treatment resistance in ovarian cancer (STRONGER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1999754.0
EU funding (EUR): 1999754.0
Participants: 1
Project status: SIGNED

Cancer therapy resistance is a complex, dynamic process. Pre-existing heterogeneity in cell states provides substance for evolutionary selection, and their plasticity enables adaptation during the therapy. Recently, we discovered a stress-related, immunocompromised cell state underpinning both intrinsic and adaptive resistance in high-grade serous ovarian cancer (HGSC) metastatic tumours, suggesting that pre-existing stress improves the resilience of cancer cells during neoadjuvant chemotherapy. To unveil how past stress responses prime cancer cells’ adaptation during therapies, I suggest a novel approach that combines dynamic stress recording with the identification of pre-existing resistant states via my novel methodology, ReSisTrace. We will apply this ground-breaking approach in patient-derived organoids to reveal how past stress signalling of a single cell is reflected in its adaptive stress responses and survival upon chemotherapy or cytotoxic immune attack. We will further characterise subclonal and spatial enrichment of the identified resistant phenotypes in longitudinal clinical specimens to incorporate the effect of tumour microenvironment in discovered mechanisms. Importantly, simultaneous characterisation of primed and adaptive resistance enables us to overcome both of them by a sequential combination of drugs where the first will drive cells to identified sensitive states prior the treatment, and the second will block identified adaptive responses during the treatment. After finding the most effective pre-sensitisers and anti-adaptive drugs in the organoids, we will validate most promising combinations in patient-derived xenograft models to pave the way for clinical translation. By targeting both pre-existing cell states and their plasticity, my novel approach will lead to a paradigm shift by providing novel, sequential therapeutic strategies to mutually overcome intrinsic and adaptive resistance in the treatment of cancer.

Keywords: single cell rna sequencing,adaptive resistance,stress,high grade serous ovarian cancer
Self-Sustained Photonic Systems through Autonomous LOSS Harvesting (bLOSSom)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Poland,Portugal,Ireland
Call: EIC Pathfinder Open (HORIZON-EIC-2025-PATHFINDEROPEN, 2025)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 2996000.0
EU funding (EUR): 2996000.0
Participants: 6
Project status: SIGNED

In the quest for efficient and sustainable technology solutions, innovative approaches to energy management are crucial. Our vision is to harness the parasitic energy (i.e., losses) of photonic integrated components and reuse it to drive the components themselves, enabling their operation with near zero external power requirements. This approach aims to revolutionize integrated photonics by drastically reducing energy consumption and enhancing sustainability. We propose collecting these energy losses using precisely designed Electro-Optical interfaces (transducers) and directing them to an integrated power management unit (PMU) that can store and release energy on demand back to the system. We plan to explore various types of harvesting interfaces, including electro-optical polymer-plasmonic joints, traditional PN junctions, and advanced approaches such as 2D materials based on graphene, as well as natural energy harvesting methods using synthetic photosystem complexes. These methods are expected to push the frontiers of interoperability between molecular physics, electronics, and integrated photonics. A key element of our vision is the creation of a photonic integrated module that is self-sustaining. This module would be part of a self-activating machine where the parasitic energy collected and managed by the PMU triggers the system and enables the module to activate. This concept has the potential to pave the way for ultra-massive integrated photonic modular networks and neuromorphic solutions, where the size of the networks can scale exponentially without a significant increase in energy requirements.

Keywords: near zero consumption devices,self sustaining photonic devices,parasitic energy harvesting,electro optical interfaces,integrated photonics,integrated power management
Solutions for constructions and bulding MAteRials based on The eNeRGy absorption (SMART-NRG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2026-02-28
Duration (months): 12.0
Total project cost (EUR): 94295.04
EU funding (EUR): 94295.04
Participants: 2
Project status: SIGNED

Energy efficiency in buildings is a critical aspect of addressing climate change and reducing greenhouse gas emissions. To contribute to this endeavor, our research project focuses on the development and optimization of phase change materials (PCMs) derived from biomass as a sustainable solution for thermal energy storage in buildings. PCMs have shown promise in enhancing energy efficiency by storing and releasing thermal energy as they undergo phase transitions. However, challenges such as low thermal conductivity and leakage have limited their widespread application, especially in construction materials. Our project seeks to address these challenges by exploring the use of natural biomass materials, such as plant fibers, wood particles, endocarps, and husks, as containers for PCMs. These lignocellulosic materials possess unique properties, including high deformation capacity and porosity, which make them promising candidates for effectively containing and activating PCMs. By utilizing biomass as PCM containers, we aim to improve the thermal performance of building materials, reducing energy consumption and greenhouse gas emissions. To achieve our objectives, we will conduct a comprehensive research program that includes experimental testing, numerical simulations, and optimization techniques.

Keywords: biomass phase change materials thermal energy storage cement based materials sustainability