Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Belgium,Germany,Austria,Czechia,Denmark,Finland,Italy,Poland,Portugal,Netherlands,United States,United Kingdom,France,Switzerland
Call: Screening platform and biomarkers for prediction and prevention of diseases of unmet public health need (HORIZON-JU-IHI-2022-03-single-stage, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 21464280.0
EU funding (EUR): 10744280.0
Participants: 35
Project status: SIGNED

EDENT1FI is a unique and timely project building and operationalising an open platform for general population screening of children/adolescents for type 1 diabetes (T1D) throughout Europe. The case is compelling: T1D is a common chronic disease affecting >1 in 300 children or adolescents. Decades of European research have signposted the step-wise nature of T1D development and generated tools for early diagnosis, monitoring and disease modification. EDENT1FI now positions Europe as the leader in early interception of T1D. Our goals are to identify individuals at earlier, pre-clinical stages, dramatically reducing clinical severity at T1D diagnosis and providing the opportunity for interventions with disease modifying therapies to delay or prevent clinical T1D. Spurred by the success of our collaborations in model European childhood screening activities and clinical networks in GPPAD and INNODIA, EDENT1FI will: establish harmonised islet autoantibody surveillance programmes to screen 200,000 children/adolescents across Europe; assess the psychosocial, medical and economic impact of screening in diverse European health systems/populations including underserved families; use state of the art metabolic sensors and biomarkers to optimise monitoring schedules for early-stage (pre-clinical) T1D aligned to maximising compliance and identifying disease progression strata; design SMART trials to expedite evaluation of disease modifying therapies; and inform and educate the public, healthcare professionals, and regulatory authorities of the new paradigms in T1D diagnosis and care. To achieve this, EDENT1FI assembles academic, clinical and industry expertise in screening, clinical care, biomarkers, machine learning, population outreach, ethics, regulatory affairs and policy to accelerate evidence-based early T1D screening into regular healthcare in Europe. The success of these activities will promote early diagnosis and prevention pathways for other chronic childhood diseases.

Keywords: monitoring,type 1 diabetes,children,validation of biomarkers,novel trial designs,communication,person related outcomes,personlised risk trajectories
Living Too Long: Republican Time in American Literature (RPTM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

How do you nurture democracy in a republic? Today, as republics around the world are straining under the pressures of authoritarianism, this question becomes almost overwhelmingly urgent. In helping to draw the blueprints for United States republicanism, Thomas Jefferson gave his answer in temporal terms: the U.S. would remain democratic as long as each generation was given power to “repair” the Constitution to suit their era, but also the obligation of handing on that document, with the entire republic, in a peaceful and timely manner to the next generation. This pattern of generational succession, which Jefferson believed would prevent any one generation from permanently stamping their likeness on the country, became essential to nineteenth-century Americans’ socio-political outlook: to be a truly democratic republic, they believed, required living in this new temporal order, which has yet to be identified by scholarship and which I am calling “republican time.” The goal of my research project, executed under the co-supervision of Hélène Quanquin and Hélène Cottet (University of Lille, France), is to investigate the relationship between republican time and the workings of democracy in nineteenth-century America. I will accomplish this goal through a program of close reading of American literature, informed by theories of political science, history, race, and gender and sexuality.

Keywords: literary criticism,political science,gender theory,race studies,philosophy
Next Generation of Artificial Heterointerfaces as Building Blocks for Energy Materials (NEXUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2491730.5
EU funding (EUR): 2491730.5
Participants: 1
Project status: SIGNED

In an era of rapid green transition changes, interfaces lie at the heart of the advances in most energy conversion and storage technologies, including batteries, Power-to-X and electrolysis. Depending on the type of device, these technologies rely upon the fast transport of atomic and electronic species across the solid-solid, solid-liquid and solid-gas interfaces. Developing viable solid-state devices requires a fundamental understanding of how ions move at the interface between two solid materials stacked together. Despite half a century of sustained research into interfaces, we still cannot answer the most critical questions about the role of interface symmetries and finding pathways for engineering fast ionic transport at room temperature. The underlying motivation to find the answers is clear: fast transport of ions provides an opportunity to accelerate energy technology. However, the fundamental science required is extremely challenging: (1) the interfaces are buried in bulk structures and (2) possible combinations of materials are limited by the rules of epitaxy. Imagine a future where the precise tuning of materials can take place according to our aspirations by assembling ultrathin layers into new artificial heterostructures. NEXUS is the epitome of this future. In NEXUS I seek to take a leap from our present knowledge by creating artificial oxide heterostructures and hybridizing their physical properties by directly stacking freestanding membranes with different crystal structures and orientations (Figure 1). In this way I will realize novel structures with fast ionic paths potentially breaking fundamental limitations of existing energy devices. During the last decade I pioneered and matured new sets of oxide-based interfaces, exhibiting an exceptionally colourful palette of properties. The approach of NEXUS is radically different from the past work and will provide fundamental breakthroughs in the study of fast ionic transport across interfaces.

Keywords: epitaxial films complex oxides freestanding membrane energy materials interfaces ionic transport
From Chrysoloras’ Latin to Erasmus’ Greek: Renaissance classical bilingualism as a European phenomenon (1397-1536) (ERASMOS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

ERASMOS hypothesizes that, in contrast to the tenet, the great age of Latin-Greek bilingualism, especially in its written form, is not to be situated in antiquity. Instead, classical bilingualism flourished in the Renaissance, a pivotal period in canonizing classics. After 1397, when M. Chrysoloras started teaching Greek in Florence, classical bilingualism developed into an authorial ideal championed by writers like Erasmus (d.1536). This ideal pervaded countless genres, far beyond classical standards. It turned into a common practice shaping Europe’s cultural identities across the Republic of Letters, where Latin-Greek code-switching occurred on a daily basis. ERASMOS opens a new research avenue on Renaissance classical bilingualism in its own right, which offers broader opportunities. The project has 3 main aims. (1) It inventories classical bilingual sources from the long 15th century (1397–1536) in a database, in order to create a new detailed heatmap of European humanism. (2) It develops digital tools for the analysis of literary multilingualism, leading to a new form of digital humanities-assisted close-reading. Most notably, the novel “tongueprint” tool will allow us to automatically calculate the linguistic make-up of texts. This tongueprint aims to further integrate multilingualism into Neo-Latin studies by cross-fertilizing the field with historical sociolinguistics. (3) ERASMOS analyzes through DH-assisted close-reading the forms and functions of classical bilingualism, in comparison to its ancient pendant, thus testing the core project hypothesis. ERASMOS, in sum, brings cultural-historical and digital-conceptual innovation. The tools developed will benefit humanities studies more broadly and will help us save a key part of European cultural history from oblivion. The project promises major advances in the study of Europe’s classical bilingualism, which connected the continent’s brightest minds in an age that fell prey to divisive ideological forces.

Keywords: classical reception studies,neo latin studies,historical sociolinguistics,digital humanities,book history,classical bilingualism,code switching,cultural history of europe in the renaissance
Silicon and T2SL EuroPean collaboration for a non-dependent supply chain for large eSWIR FPAs (STEP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: France,Sweden,Germany
Call: Space technologies for European non-dependence and competitiveness (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2023-12-01
End date: 2027-05-31
Duration (months): 42.0
Total project cost (EUR): 3905316.59
EU funding (EUR): 3058895.74
Participants: 4
Project status: SIGNED

In the last years, Mercury Cadmium Telluride (MCT) IR Focal Plane Arrays (FPAs) have drastically boosted the observational capabilities of space IR payloads. In the US, industrial production of MCT IR FPAs with formats up to 4K×4K pixels is established, while in Europe, initiatives from European Institutions and most advanced EU manufacturers are currently on-going to progress on large format MCT hybrids such as 2kx2k, though the industrial set-up necessary to support operational space programs remains to be elaborated and matured. As instruments designers are asking for larger size FPAs, EU detector manufacturers are losing ground with respect to US competitors. T2SL technology is an alternative to MCT for the manufacturing of IR FPAs. In the US, progress on T2SL FPA development led to up to 8K×8K IR FPAs demonstrations, but like US MCT ones, these are not easily available for the EU market due to strong export/ITAR restrictions. Moreover, US ROICs feature better performances and interfaces compared to their EU counterparts. The STEP project will provide a disruptive European supply chain fully focused on the design and manufacturing of competitive and affordable large format T2SL eSWIR FPAs. STEP will incorporate all steps of the IR FPA production chain: detector design, large scale growth, fabrication, hybridization, large format and high performances scalable ROIC with dedicated features to improve eSWIR space FPA performances, and evaluation of large space prototype FPAs (including space environment evaluation). STEP will benefit from a European complementary consortium team: Airbus, the well-known space industrial (requirements, performances testing, environment evaluation, space missions insertion and business plan), the European leader in T2SL manufacturing, IRnova (high performances eSWIR T2SL design & characterization, FPA space prototype manufacturing and non-space applications insertion), a world class RTO, Fraunhofer IAF (T2SL manufacturing and characterization), and a leader in aerospace research ISAE-SUPAERO (high performance large format ROIC design & validation and establishment of a EU large format digital space ROIC line).

Keywords: t2sl,swir,mbe growth,fpa,european supply chain,roic
Strengthening Regulatory Capacities for Clinical Trials Oversight in Southern Africa: South-South and South-North Collaboration Initiative for Regulatory Bodies. (SEARCH II)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Coordination and support actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Botswana,Eswatini,Lesotho,Mozambique,United Kingdom,Zambia,Namibia,Portugal
Call: Strengthening regulatory capacity for supporting conduct of clinical trials (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 599947.5
EU funding (EUR): 599947.5
Participants: 9
Project status: SIGNED

The Southern Africa Regulatory for Clinical Research (SEARCH) is a consortium established in 2020 under the second program of the EDCTP, designed to develop and promote a framework for collaboration, harmonization process and support regulatory capacity and develop technical expertise in Southern African countries to support the conduct of clinical trials (CT). It is composed of four institutions from Southern Africa and one European. In this proposal, SEARCH II, eight institutions come together to strengthen and increase the capacities for the clinical trials review process in Southern Africa built from the SEARCH I project, including the issuance of relevant permits, CT oversight and clinical research pharmacovigilance and post-trial market authorisation by NRAs. However, insufficient access to quality, safe, efficacious and affordable medical products in Southern Africa has imposed significant challenges on public health for decades. This, in part, is attributed to weakness or absence of technical expertise, lack of policies, guidelines and regulatory systems, a lack of competent regulatory professionals in the National Medicines Regulatory Authority (NMRAs) and ineffective regional collaborations among the NRAs and NECs. In response to these regulatory challenges, the SEARCH I project initiated a process of regional harmonisation efforts and conducted SWOT analysis among the southern African members, and developed a comprehensive common plan for continuous improvement and overcoming gaps at the beneficiary country level and effective harmonization of regulatory and ethical review processes. The SEARCH II project aims to support the national regulatory capacity system, develop technical expertise and continue promoting the South-South and North-South collaboration built from the SEARCH I project, while also enhancing and advocating the establishment and structuring of NRAs and NECs in Botswana, Eswatini, Lesotho, Mozambique, Namibia and Zambia.

Keywords: review process
Pregnancy and Infant PrEparedness pLatform IN Europe (PIPELINE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Italy,United Kingdom,Netherlands,Belgium,France,Spain
Call: Pandemic preparedness and response: Adaptive platform trials for pandemic preparedness (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 9999975.25
EU funding (EUR): 9999975.25
Participants: 16
Project status: SIGNED

Recent epidemics have highlighted how infectious disease outbreaks can severely and sometimes uniquely affect the short and longer term health of pregnant women and their infants. Nevertheless, these groups are invariably excluded from pandemic preparedness and response research, as during the COVID-19 pandemic. Our ambition is to develop a dedicated pregnancy-infant preparedness platform for adaptive trials, to improve pandemic preparedness for these underserved populations. The objectives of PIPELINE are to: 1) establish a multi-country adaptive trials platform that that can support novel diagnostics, vaccines and therapeutics for infections in pregnancy and infancy, able to pivot rapidly to emerging health threats; 2) create and sustain a responsive and “ever-warm” clinical trial network of sites with expertise in recruiting pregnant women and infants and adaptive trial designs; 3) undertake an adaptive platform trial on respiratory syncytial virus immunisation in pregnant women and infants, to test the platform’s capabilities and address a public health priority for the EU; 4) evaluate novel sampling techniques and immunity approaches with relevance for preparedness; and 5) embed all activities within sustained dissemination, exploitation and communication with key stakeholders to translate results into policy recommendations. We will achieve these objectives through our multidisciplinary partnership with track records in maternal and infant health research, who will leverage and strengthen existing networks to maximise Europe-wide outreach to benefit PIPELINE. Our objectives are aligned with Horizon Europe Work Programme 2023-24 Health Destination 3 “Tackling diseases and reducing disease burden” as our work will reduce the health burden of disease through more effective management, lead to improved preparedness of health systems to respond to health emergencies, and reduce citizens’ risk of, and increase their knowledge about, health threats of epidemics.

Keywords: pregnancy vaccines infants
DIAgnostics, MOdeling and coNtrol of airfoils in Dynamic Stall regimes (DIAMONDS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Aerodynamic forces generated by rotor blades and wings in unsteady regime modulates when the angle-of-attack (AoA) is dynamically varied. One of the important phenomena that occurs with the increase in the magnitude of the AoA modulations is the dynamic stall (DS) which entails large excursions of the aerodynamic forces in turn introducing strong vibrations (alongside noise generation) and structural fatigue. The emergence of 3D flow features (i.e. stall cells) further complicates the DS phenomenon and leads to spanwise modulation of lift and drag. Overally, DIAMONDS seeks to address time-resolved (TR) and three-dimensional (3D) diagnostics, modeling and control of airfoils in DS regimes. Objectives of DIAMONDS are: 1) characterization of the pitching airfoil in the DS regime using a TR-3D particle tracking velocimetry (PTV) method, 2) investigation of leading-edge (LE) tubercles to control spanwise lift and drag modulation acting on the stall cells, and 3) development of an unsteady stall cell characterization model through extension of the unsteady lifting-line theory (ULLT) to the 3D flow structures also in presence of LE tubercles. Implemented in TU Delft, and supervised by Prof. Fulvio Scarano and Dr. Morgan Mogeng Li, DIAMONDS will allow me to diversify my individual competence by acquiring new scientific and non-scientific skills. DIAMONDS will strongly benefit my inter-sectoral and interdisciplinary expertise and strengthen my international network. A two-way transfer of knowledge is guaranteed since DIAMONDS combines my expertise in analytical aerodynamic modeling with the host’s expertise in the state-of-the-art 3D optical flow diagnostics methods. In addition to creating high quality new knowledge about stall cells and DS phenomenon and it’s control, DIAMONDS leads to wind turbines and rotorcraft that are safer and much quieter and have less environmental consequences and also makes it possible to fly with less fuel or generate energy at a lower cost.

Keywords: unsteady aerodynamics,flow control,dynamic stall,stall cells,airfoil leading edge tubercle,wind tunnel testing,particle tracking velocimetry,lifting line theory,wind turbine,rotorcraft