Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
HetERogeneous sEmantic Data integratIon for the guT-bRain interplaY (HEREDITARY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Italy,Bulgaria,Netherlands,Spain,Denmark,Belgium,Austria,Portugal,Germany,Switzerland,United States
Call: Better integration and use of health-related real-world and research data, including genomics, for improved clinical outcomes (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 9988833.75
EU funding (EUR): 9988833.75
Participants: 18
Project status: SIGNED

HEREDITARY aims to significantly transform the way we approach disease detection, prepare treatment response, and explore medical knowledge by building a robust, interoperable, trustworthy and secure framework that integrates multimodal health data (including genetic data) while ensuring compliance with cross-national privacy-preserving policies. The HEREDITARY framework comprises five interconnected layers, from federated data processing and semantic data integration to visual interaction. By utilizing advanced federated analytics and learning workflows, we aim to identify new risk factors and treatment responses focusing, as exploratory use cases, on neurodegenerative and gut microbiome related disorders. HEREDITARY is harmonizing and linking various sources of clinical, genomic, and environmental data on a large scale. This enables clinicians, researchers, and policymakers to understand these diseases better and develop more effective treatment strategies. HEREDITARY adheres to the citizen science paradigm to ensure that patients and the public have a primary role in guiding scientific and medical research while maintaining full control of their data. Our goal is to change the way we approach healthcare by unlocking insights that were previously impossible to obtain.

Keywords: multimodal health data federated networking infrastructure
Is International Refugee Law Effective? (RefLex)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland,United States,Canada
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 3
Project status: SIGNED

Is International Refugee Law effective? This is the central question of RefLex, a project that will offer the first comprehensive empirical study of the workings and effectiveness of International Refugee Law (IRL), a body of law partly imbricated with International Human Rights Law (IHRL), domesticated and judicialized to an extraordinary degree across the globe. There are many theoretically and empirically rich studies of effectiveness of International Human Rights Law (IHRL), as well as many other fields of International Law (IL) in constructivist International Relations (IR) in particular. The effectiveness of human rights courts and other bodies is also a well-established academic subfield. However, there are no analogous empirical studies of IRL in practice. RefLex will fill this huge puzzling knowledge gap, thereby making a vital contribution both to refugee studies and to scholarship on the theory and practical workings of IL. It will develop a new dataset, the Refugee Protection Index (RPI), in order to enable our (and other) large-n quantitative studies, identify key cases to trace how IRL comes to be effective, or not. It will also contribute to the burgeoning field of legal mobilization (LM) studies, which again, have failed to examine refugee legal mobilisation in comparative or transnational fashion. It will break new ground here also, by studying LM from above and below by studying both UNHCR’s own LM and that of refugees themselves, both acting via transnational organisations and in local settings. The analysis of the RPI will inform the choice of LM casestudies, in order to develop a new account of when LM emerges and when it is effective. The project aims to provide vital insights at a time when the Global Refugee Regime (GRR) is seen to be increasingly adrift from IL, with over challenges to core norms, and practices focusing on informal cooperation, ‘deals’ and political trading, lacking normative specificity and legal force.

Keywords: international refugee law effectiveness of international treaties and norms impact of human rights courts and un treaty bodies legal mobilization role of unhcr refugee legal mobilization
Real time Liver disease early diagnosis through exhaled Volatile Organic Compounds sensing (ReLiV)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Israel
Call: EIC Transition Challenge: Full scale Micro-Nano-Bio devices for medical and medical research applications (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 2499875.0
EU funding (EUR): 2499875.0
Participants: 1
Project status: SIGNED

The analysis of volatile organic compounds (VOCs) in exhaled breath with nano sensors has great potential to transform healthcare, with accurate, inexpensive, real-time diagnostics. However, attempts to implement this strategy have failed to reach clinical deployment. Firstly, many efforts try to identify the complex mixture of VOCs associated with disease, which is a long and expensive process. Secondly, commercially available sensors require high operating temperatures and have low sensitivity to breath VOCs. NaNose Medical has overcome these limitations through DiaNose, an easy to use, hand-held diagnostics device with potential applicability in >20 different diseases. Instead of identifying individual VOCs, DiaNose deploys an array of patented cross-reactive sensors delivering a chemical signature of breath that can be classified as healthy or diseased through artificial intelligence. Our initial alpha prototype focuses on a key clinical indication: Non-Alcoholic Fatty Liver Disease (NAFLD): with a global prevalence of 30%, it is the leading cause of liver related morbidity, generating an annual burden in Europe of > €35 billion and a further €200 billion of societal costs. Crucially, NAFLD diagnostics present key limitations: liver biopsies are expensive, invasive and subject to sampling error, and non-invasive alternatives lack precision, are operator-dependent, and require expert interpretation. DiaNose will fill this gap, aiming to achieve a diagnostic accuracy of >90% at <50€/test. Lab testing of our alpha prototype has shown high accuracy (88%) with NAFLD models. With the ReLiV project, we will develop an advanced beta prototype that will be validated in clinical settings across different locations. This will bring DiaNose one step closer to commercialization, providing a truly cost-effective, point-of-care detection and monitoring device capable of improving patient outcomes and alleviating the economic burden generated by the growing NAFLD pandemic.

Keywords: preventive healthcare,public health,community accessible diagnostics,liver disease,steatosis,cancer surveillance,early detection,stratification,sensing,breath analysis,nanotechnology
Chemical rewiring of E3 ubiquitin ligases as a generalizable therapeutic approach (TrickE3)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-03-01
End date: 2027-02-28
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: SIGNED

Classical drug design relies mostly on the availability of accessible pockets to block specific protein activities. Despite tremendous progress, more than 80% of all human proteins remain beyond the reach of traditional inhibitor-centric approaches. Chemical ablation of protein abundance using bivalent degraders (PROTACs) moves away from an occupancy-driven (inhibition) to an event-driven (binding) pharmacology. However, their design is intrinsically limited to targets that are ligandable via chemical probes. To tackle current unmet clinical problems, we need transformative paradigms. Fortuitous discoveries have illustrated the immense potential of monovalent degraders. These molecules induce the degradation of target proteins by molecular gluing to E3 ubiquitin ligases or by prompting their destabilization. They have desirable drug-like properties, proven capacity to induce the degradation of proteins otherwise deemed undruggable, and they are already a clinical reality. However, their discovery has been driven by serendipity, thereby hampering their realization as a generalizable drug solution. TrickE3 seeks to establish the foundations for the systematic development of monovalent degraders. To this end, we will develop innovative methodologies to detect and predict drug-induced changes in the interactome/activity of E3s at scale. As proof of principle, we will focus on the chemical rewiring of E3s expressed in pancreatic ductal adenocarcinoma (PDAC) due to the imperative need for treatments. We intend to prospectively identify monovalent degraders (i) of specific vulnerabilities, and (ii) to unlock new PDAC targets. At the interface of chemical biology and cancer research, TrickE3 will be an instrumental resource to broaden drug discovery efforts, probe disease-relevant vulnerabilities and, overall, widen the targetable space of the human proteome. We hope to empower other disciplines to chemically explore, without limits, the degradation of relevant targets.

Keywords: monovalent degraders,novel therapeutic approaches,targeted protein degradation,e3 ubiquitin ligases,targeting the undruggable,unmet clinical needs,pancreatic ductal adenocarcinoma
Harmonic Brushless Field Excitation Methods for Electrical Machines (HARMFIX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-11-30
Duration (months): 25.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 3
Project status: SIGNED

This project is focused on the design and development of new rotor field excitation methods to achieve brushless operation for wound-field electrical machines (EMs). The proposed method will provide an opportunity to reduce the reliance of EMs on rare-earth materials of which EU is lacking its resources and eliminate the usage of brushes for their rotor field excitation while improving the reliability and cost-efficiency of the machine systems. Through this method, a new armature winding configuration will be developed to generate not only the fundamental magnetomotive force (MMF) but also a suitable harmonic MMF component in the airgap of the EMs, while powered from a single customary current-controlled voltage source inverter (VSI). The rotor of these machines will be altered to house both harmonic and field windings. The harmonic MMF component will be employed to induce a harmonic current in the harmonic winding of the rotor, which will be rectified to excite the rotor field winding to achieve brushless operation and develop torque. A new topology optimization methodology will be developed to optimize the windings and minimize copper consumption. The EMs employing HARMFIX do not require rare-earth materials, costly auxiliary electromechanical excitation systems or custom-made power electronics circuitry, or control strategies for their brushless operation. Therefore, this method is a truly viable and sustainable alternative for commercial products which are currently employing rare-earth materials, brushless exciters or brushes, and slip rings.

Keywords: electrical machines
Nuclear Quantum Information Processing Controlled via Hyperfine Interaction with Electrons (nQUICHE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2485658.0
EU funding (EUR): 2485658.0
Participants: 1
Project status: SIGNED

Quantum RAM (QRAM) is a key quantum computing resource featuring in many theoretical proposals that has never been demonstrated in experiment. A QRAM is a quantum memory in which one can read or write quantum information to a superposition of memory cells. Such a device is powerful as a tool for implementing many quantum algorithms, including Grover’s search algorithm, quantum chemistry, quantum cryptography and quantum machine learning, and is regarded by many as essential for a future quantum computer. Nuclear Quantum Information processing Controlled via Hyperfine interaction with Electrons (nQUICHE) aims to use recently developed techniques in single spin detection, spectroscopy and coherent control to demonstrate a quantum router, the unit cell of a QRAM, using electron and nuclear spins in the solid state coupled to superconducting circuits. The hybrid spin architecture proposed in nQUICHE has a baked-in double controlled-SWAP interaction that efficiently routes quantum information into memory qubits with seconds-long coherence times, making the system particularly well suited to realising a QRAM. Beyond QRAM, nQUICHE will expand the toolbox of techniques for solid state spin quantum information processing and will investigate new crystal hosts and an alterative spin system with a large nuclear spin of 7/2, exploring its 16-dimensional Hilbert space. Architectures for controlling large arrays of spins and interfacing with superconducting circuits in a scalable, modular architecture will be developed. These experiments are relevant not only for constructing a QRAM, but also for quantum computation and networking with this platform. The techniques developed will push the frontiers of electron paramagnetic resonance. In addition to having technological applications, experiments performed during nQUICHE will explore novel effects with single spins that are of interest from a purely fundamental physics perspective.

Keywords: spin,hybrid,electron paramagnetic resonance,superconducting devices,circuit qed,circuits,nuclear spin,electron spin,qubit,quantum devices,quantum sensing,quantum ram,qram,quantum memory
SKeletal Muscle - REgulation of FORce and Maturation through Tubulin isotypes (SKM-REFORMAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-05
End date: 2028-01-04
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

Microtubules are formed by polymerization of tubulin heterodimers. Tubulin monomers rise from 16 genes each with their own spatiotemporal signature, resulting in a patterned microtubule network. As tubulin dimers define binding microtubule associated proteins (MAPs) and occurring post-translational modifications (PTMs), I wonder whether microtubule properties and patterns are encoded/defined by the tubulin isotypes themselves. This proposal aims at 1-confirmation of the expressed tubulin isotypes in skeletal muscle, depending on developmental stages, sex, and fiber type. 2-Understanding of how tubulin isotypes contribute to macroscopic phenotypes such as myoblasts fusion, general fiber organization and muscle contraction. 3-Deciphering of the molecular mechanisms at play upon tubulin isotype loss-of-function. 4-Assessement of potential beneficial effects of tubulin loss-of-function in diseases such as Duchenne muscular Dystrophy (DMD), Centronuclear Myopathy (CNM), and myasthenia. Using innovative in vitro differentiation tools, animal models and state of the art microscopy, I will explore all potential effects of selected tubulin isotypes, from macroscopic phenotypes to molecular mechanisms, as well as in disease. Expected techniques to use are: RT-q-PCR, co-cultures motoneurons-myoblasts, CRISPR/Cas9 mediated KO, shRNA KD, gene transfer by AAV injection, force measurement in vivo and ex vivo, immunohisto- and cytochemistry, live-imaging with fluorescent probes, and image analysis. Microtubule and tubulin being involved in many types of diseases (cancer, development, degeneration…) this project will lead to many economic, social and therapeutic benefits.

Keywords: microtubules,tubulin isotypes,skeletal muscle,post translational modifications,motor unit,ipscs,crispr cas9 gene editing
Global Cleavages: The Shape of Political Conflict across World Regions in Historical Perspective (GLOBAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 2499931.0
EU funding (EUR): 2499931.0
Participants: 1
Project status: SIGNED

This project investigates the dimensionality of global politics. It analyses the cleavages that structure world politics and asks whether conflicts are shaped territorially or along functional dimensions cutting across world regions. The question of whether individuals worldwide are opposed territorially or according to socio-economic and cultural groups is addressed in a long-term empirical analysis spanning historical phases from the 19th century to the present. The goal is to establish if, and under what conditions, international divisions opposing world regions – core−periphery, North−South, or civilizational contrasts –increasingly blur giving way to conflict lines that oppose groups functionally, such as class or education. This is done at the level of citizens, actors and institutions. GLOBAL combines a comparative approach (to detect convergence between world regions) and supranational one (to detect functional dimensionality in global discourse and institutions). The project categorizes cleavages according to three types of inequality: socioeconomic, political-military and cultural. Unlike economic work, it focuses on the politics of inequality, i.e. how actors compete to politicize different inequalities, with narratives legitimizing a more or less equitable redistribution of resources to correct for inequalities. A multi-pronged research strategy based on statistical, scaling, GIS and network methods is used to analyse electoral, socio-economic, roll-call, text, survey and organizational data. GLOBAL will be led by Daniele Caramani and hosted at the European Governance and Politics Programme (European University Institute), of which he is the director. It will lead to an authored book by the PI that follows – as third instalment with common theoretical foundations – the volumes on the nationalization and Europeanization of politics (Cambridge UP, 2004, 2015), as well as a special issue, an edited volume and 11 journal articles by the researq

Keywords: world politics,political cleavages,global territoriality,class inequality,left right,core periphery,civilizational divides,quantitative longitudinal analysis
Ex-Soldiers of Empire: Colonial Veterancy in the Interwar World (COLVET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-04-01
End date: 2028-03-31
Duration (months): 48.0
Total project cost (EUR): 1196801.0
EU funding (EUR): 1196801.0
Participants: 1
Project status: SIGNED

COLVET will develop the first comprehensive and comparative account of colonial veterancy in what was the foundational era for modern conceptions of the veteran, the interwar period. Grounded in a collaborative and comparative methodology, the project will trace and analyse the contrasts and commonalities in the evolution and reception of veteran policy within, across, and between the French Empire, the Italian Empire, the American colonial empire, British-ruled East Africa, and British-ruled India. This innovative research will not only deepen our understanding of veteran history around the world in the period but also help us reimagine the concepts we use to analyse veterans and their stories so they can better capture the diversity of veteran experiences. The project has four principal aims: 1. To trace and compare the history of veteran experiences and policy across colonial contexts and imperial polities. 2. To use veteran policy and the responses it elicited to explore the nature of colonial rule across interwar empires. 3. To expand the imagined geography of veteran history in the period to include colonial veterans. 4. To reimagine the conceptual framework of veteran history so it can better incorporate colonial veterans alongside veterans from the rest of the world. To achieve these aims, the COLVET team will explore key questions around the definition and regulation of veterancy, the political recognition and mobilisation of veterans, and the systems set up to cater for and control veterans across a range colonial territories and imperial polities. The project design ensures that the original research this generates will then be put into dialogue with scholarship on and scholars of veterans in other contexts, colonial and non-colonial. This collaborative and comparative approach will allow the team to co-produce a new analytical framework that will facilitate the writing of a truly global history of the veteran.

Keywords: veteran history,history of the welfare state,imperial history,military history,anti colonialism