Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bioinspired Catalytic Metallofoldamers (Foldmetcat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Inspired by mimicking the characteristics of terpenoid cyclase enzymes, the goal of this proposal is to design new types of catalysts containing electrophilic transition metal centers that could simultaneously fold and activate polyunsaturated substrates promoting non-inherent cyclization modes. Our goal is unprecedented, although it is rooted on fundamental organometallic chemistry, in particular, on the known activation of polyunsaturated substrates by highly electrophilic transition metals. These unconventional cyclizations cascades challenge the paradigm that the intrinsic reactivity of the substrate is the relevant factor in carbocation-initiated processes and would provide access to large carbocyclic skeletons such as those present in taxol and ophiobolin enantioselectively in a single step under catalytic conditions. Although the initial work will be carried out with gold catalysts, a major goal of this research is to develop other general-purpose efficient chiral electrophilic catalysts based on zinc. To attain our goal, we will study more simple catalysts to delineate the factors that control the folding of polyenynes and polyenes. Thus, we will prepare new series of C2-chiral catalysts in which the stereogenic elements are close to the reaction site. Related C2-chiral systems will be generated by supramolecular hydrogen-bond pairing. A similar chiral arrangement could also be achieved by an intramolecular chiral anion translocation from the metal to a distant hydrogen-bond donor site. In addition, we will explore larger systems based on structurally well-defined metallic clusters to generate highly electrophilic chiral reactive sites. The folding and activation of polyunsaturated substrates will be studied first with a series of catalytic prototypes based on digold or heterobimetallic complexes with N-heterocyclic carbenes, diphosphines, mixed ligands of these types, as well as resorcinarene-phosphonite cavitant ligands.

Keywords: homogeneous catalysis,transition metal catalysis,organic synthesis
Polycentric Carbon Pricing Governance: Cooperation, Contestation and Connectivity (PolyCarbon)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1450000.0
EU funding (EUR): 1450000.0
Participants: 1
Project status: SIGNED

The PolyCarbon project’s objective is to uncover, investigate and understand the underlying mechanisms and conditions for the expansion and contraction of the global system of carbon pricing governance. It will (1) chart the entire global system of carbon pricing policies, (2) explain the causes of adoption and rejection of (ambitious) carbon pricing policies, and (3) analyse the interaction amongst the various carbon pricing policies globally. The global system of carbon pricing policies will become exponentially more effective as it expands since carbon leakage is reduced. Carefully crafted and ambitious carbon pricing policies can be powerful tools for transitioning to a low-carbon economy in the urgent pursuit of international climate goals. Understanding the underlying mechanisms and conditions for the expansion and contraction of the global system of carbon pricing governance can provide insights for fast-tracking its formation; thus, accelerating the transition to a low-carbon economy. The PolyCarbon project will develop a novel analytical framework that captures the complexity of local and transnational processes and their interaction. This framework will guide the creation of a unique and expansive database of carbon pricing policies. The database will be used for a comprehensive multi-method analysis, combining qualitative network analysis and case studies.

Keywords: policy diffusion,polycentric governance,norm contestation,international cooperation
Chair Of Micro Process Engineering and TEchnology (COMPETE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Slovenia
Call: ERA Chairs (H2020-WIDESPREAD-03-2017-ERAChairs, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2500450.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The project will establish the ERA Chair Of Micro Process Engineering and TEchnology – COMPETE. It is designed to capitalise on microfluidics research and technology, an existing knowledge base of University of Ljubljana (UL) to a leading European hub of microfluidics expertise. Microfluidics offers huge potential for new solutions in biomedicine, biotechnology, food quality assessment and environmental protection, and is directly in line with the Slovenian Smart Specialization Strategy. To achieve this ambition, the Chair will integrate micro-process engineering disciplines – chemical, mechanical and electrical engineering – with basic research in biophysics, chemistry and microbiology in order to overcome the main barriers for research excellence in this highly interdisciplinary field. COMPETE will address the lack of institutional organization connecting research teams and infrastructure within UL, lack of financing, and practice not in line with open recruitment policy. Attracting a Chair Holder with excellent research credentials and leadership competences, thus creating a research team with broad expertise and wide network for collaboration that will greatly improve the culture of research and research performance at UL. Cooperation with other research, industrial, governmental and non-governmental entities and dissemination are key activities that will complement internal structural changes and help build sustainability and a wider impact of the Chair as a leading regional centre for micro-process engineering. Sustainability will be granted by research funding procurement for projects, structured cooperation with industrial and public research and educational entities, establishment of a new study field in the doctoral programs at UL, PhD summer school and other training programs. By setting a best practice example and through a well-thought outreach campaign the project will stimulate structural changes throughout UL

Keywords: micro process engineering,microfluidics,production optimization,biosensors,cell analysis,electroporation
Regulation of DNA resection, DNA repair and genomic stability by cohesin in undifferentiated Caenorhabditis elegans germ cells (coDNAres)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

DNA double-strand breaks (DSBs) are the most hazardous type of DNA damage threatening genomic stability. Thus, eukaryotes developed different mechanisms of DNA damage response and DNA repair pathways which are highly conserved, but not fully understood. To keep a control between error-prone (Non-Homologous End-Joining, NHEJ) and high-fidelity (Homologous Recombination, HR) mechanisms of DSB repair is essential for cell fitness, mainly exerted at the level of licensing HR by the initial step of the pathway known as DNA end resection. Therefore, a full study of this step is essential to understand genetic diseases, as cancer, with a high potential to direct future therapeutic strategies. Cohesin complexes are high conserved factors with several roles in preventing genome instability. Cohesin are a tripartite structure ring-like where only the kleisin subunit differ, the meiosis-specific Rec8 kleisin substitutes its mitotic counterpart Rad21/Scc1. It has been described roles for cohesin in chromosome segregation and DNA repair, but as short, all based in providing close proximity of sister chromatids. But little it’s known about an active function in DNA repair further tethering DNA molecules, e. g. participating in the decision of NHEJ/HR pathway, mediating early DNA resection, or targeting other repair proteins to damage sites regulating the DNA damage response, all aims of this proposal. We will combine the expertise of the applicant in cohesin in nematodes and the host laboratory in DNA repair to shed light and compare the active contribution in DNA repair of the SCC-1- and REC-8-cohesin complexes. The use of Caenorhabditis elegans as model system will provide a portal to the study of systemic DNA damage response mechanisms in a tissue- specific way, here the mitotically proliferating undifferentiated germ cells, of great interest for the host lab.

Keywords: dna repair,dna resection,dna damage response,cohesin,caenorhabditis elegans,rec8,scc1
FI-GLOBAL: Building and supporting a global open community of FIWARE innovators and users (FI-GLOBAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,France,France,France
Call: Net Innovation Initiative (H2020-ICT-2016-1, 2016)
Start date: 2016-10-01
End date: 2019-03-31
Duration (months): 30.0
Total project cost (EUR): 1710435.25
EU funding (EUR): 1397764.75
Participants: 7
Project status: CLOSED

Through the FIWARE Mundus activities, mostly performed in the FI-LINKS project, countries from all over the world have already started to mobilize innovators and users around new FIWARE ecosystems. FIWARE is currently stepping out from experimentation into commercialisation. The technology must be adopted at global level in order to allow European FIWARE stakeholders to expand their reach worldwide. The first main objective of FI-GLOBAL is to underpin a FIWARE global community, by increasing the number of FIWARE ecosystems all around the world. FI-GLOBAL will identify and engage multiple stakeholders, who will help bootstrapping innovation ecosystems around FIWARE, provide support to startups, enhance the open platform with additional FIWARE components, and deploy new FIWARE nodes. FI-GLOBAL facilitates the set-up of a worldwide recognized FIWARE Master Course to educate future students and establish international cooperation via a FIWARE Education Community. The second main objective is to incentivise the take-up of the FIWARE platform and facilitate the means for an effective cooperation among innovators and users from the global community. FI-GLOBAL will mobilize a truly global marketplace of FIWARE applications that will stimulate new solutions and business ideas, and incentivize innovators and users to discover the platform and adopt the technology. This will be done by providing tools that support the cooperation among the global ecosystems to implement new ideas/services and match particular needs that may have been already tackled by FIWARE solutions; and launching a FIWARE Global Piloting Programme to encourage the improvement and replicability of FIWARE solutions at global scale. Reaching these objectives will contribute to make FIWARE the “de facto” reference in terms of global open source platform for the development of solutions and applications and one of the main instruments for promoting entrepreneurship and strengthening digital education worldwide

Keywords: fiware,fiware mundus,fiware communities
From planetary birth with aperture masking interferometry to nulling with Lithium Niobate technology (LITHIUM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 1851881.0
EU funding (EUR): 1851881.0
Participants: 1
Project status: CLOSED

Observing the process of planetary accretion is crucial to inform models of planet formation. Most of the key action is expected to happen in the gaps of protostellar disks – a spatial realm over which aperture masking interferometry has demonstrated a unique ability to deliver incisive imaging. Masking offers twin advantages of higher dynamic range at the diffraction limit (lambda/D) than differential imaging, while at the same time giving nearly complete Fourier coverage compared to long baseline interferometry. The founding objective of this proposal is to create expertise and technology to understand the astrophysical phenomena so far only glimpsed in faint detections in stellar gaps such as those published in T Cha (Huelamo et al. 2011), HD142527 (Biller et al. 2012) and FL Cha (Cieza et al. 2013). But the central goal of this project is to further advance the experimental technique. Reaching even higher dynamic range for fainter detections is essential for probing planetary birth. The way to improve the dynamic range is clear: increase the accuracy of the primary closure phase observable. To do so, we will follow two paths. The first will use laboratory experimentations to analyse and understand the sources of bias to the closure phase. The resulting end-product will be better software offered to the community, and better techniques for a next generation of aperture masking devices. The second path is to amplify the closure phase signal by combining nulling with closure phase (Lacour et al. 2014). This second path is the most challenging, but will be an important breakthrough to the field. Nulling is to aperture masking what coronagraphy is to classical imaging. Without a first level of nulling, the aperture masking technique will always be limited by the photon noise due to the stellar light. We propose to build on our experience of Lithium Niobate integrated optics devices to bring aperture masking to a new level of performance in high dynamic range imaging.

Keywords: young stellar objects,high contrast imaging,optical interferometry
Silicon Nitride Photonic Integrated Circuit Pilot line for Life Science Applications in the Visible Range (PIX4LIFE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Ireland,Germany,Germany,Germany,Spain,Spain,Sweden,Belgium,Belgium,Belgium,Netherlands
Call: Cross-cutting ICT KETs (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2020-09-30
Duration (months): 57.0
Total project cost (EUR): 10229106.89
EU funding (EUR): 8557337.879999999
Participants: 18
Project status: CLOSED

Photonics is essential in today’s life science technology. PIX4life will mature a state of the art silicon nitride (SiN) photonics pilot line for life science applications in the visible range and pave the way to make it accessible as an enabler for product development by a broad range of industrial customers. We aim at 1) establishing a validated CMOS compatible SiN technology platform in the visible range for complex densely integrated photonics integrated circuits (PICs), 2) developing a supply chain to integrate mature semiconductor laser sources and CMOS detector arrays with the SiN PICs on the basis of technologies that are scalable to high volume, 3) establishing appropriate design kits and tools, 4) demonstrating the performance of the pilot line for well-chosen life science applications in the domain of vital sensing, multispectral sources for super-resolution microscopy, cytometry and 3D tissue imaging, 5) setting up the logistics for multi-project-wafer (MPW) access to the pilot line. Integrated photonics has demonstrated that optical functions can be realized in a more compact, robust and cost-effective way by integrating functionalities on a single chip. At present industrialization is limited to telecom applications at infrared wavelengths. The field of life sciences is heavily dependent on bulky and expensive optical systems and would benefit enormously from low cost photonic implementations. However this field requires a visible light PIC-technology. Proof of concept demonstrations are abundant, but pilot line and manufacturing capacity is limited, inhibiting industrial take up. PIX4life will drive the future European RTD in visible photonic applications for life sciences by bridging technological research (via participation of 2 academic and 2 research institutes) towards industrial development (via participation of a foundry, two large companies and 9 fabless SME’s, either technology suppliers or life science end users).

Keywords: photonic integrated circuits,biophotonics,pilot line,visible
THE NON-ABELIAN HODGE THEORY OF AN ORBIFOLD KLEIN SURFACE (HORUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

For centuries, mathematical concepts have inspired technological progress. As the distance between fundamental research and applications shortens, the impact of mathematics on our everyday lives becomes stronger, and the long-standing European tradition of excellence in mathematical research reaffirms itself as a key factor of sustainable economic growth. In line with that tradition, the goal of the present project is to achieve and disseminate high-impact research results in the field of Differential Geometry, that will irrigate related disciplines, such as Theoretical Physics and, in the longer run, more applied fields. The applicant’s outstanding research record in Gauge Theory and Representations of Fuchsian Groups, combined with the expertise of his European hosts in the rapidly growing area known as Higher Teichmüller Theory, make the proposed collaboration between them unique, timely, and ideally shaped for success. The research results that they are setting out to obtain will redefine the field and open new lines of research. Moreover, the host institution is committed to providing high-quality training of the applicant at every step of the action, from concrete initiatives to reduce the gender gap in mathematical sciences to the use of technological tools for the dissemination and communication of research results. The completion of the present research project will thus bring a significant boost to the applicant’s career and establish the host institution as a pioneer in a new line of research, hereby strengthening its tradition of excellence and innovation. The project is in accordance with the recommendations of the 2016 consultation of the European Commission for Mathematics in Europe, according to which “the wealth of mathematical competence in Europe and its potential for European science and industry is undeniable”.

Keywords: fuchsian groups higher teichm ller theory
Wearable chemical sensors for public health-based business models (WoRShIP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-10-01
End date: 2020-09-30
Duration (months): 12.0
Total project cost (EUR): 128750.0
EU funding (EUR): 128750.0
Participants: 1
Project status: CLOSED

The monitoring of sources and sinks of air pollutants and green house gases (GhG) is no longer a purely scientific task but transcends to all areas of human life. In recent years it has become abundantly clear that exposure to and evolution of air pollutants is a fundamental parameter for health and well-being of the general population as well as a corner stone in next generation agriculture and safety applications. However, currently no technologies or even technology concepts for high resolution, large-scale monitoring are available that could enable a quantification of pollutant/GhG concentrations and fluxes at relevant temporal and/or spatial scales. Currently, commercially available state-of-the–art sensors or satellite-based methods fail to strike the balance between reasonable investment and necessary accuracy for larger scale monitoring. WoePal UG possesses a unique and disruptive photoacoustic gas detection technology, that enables the fabrication of miniaturized, highly selective and sensitive gas analyser systems for the most important GhGs (CO2, CH4) and air pollutants (NO2, CO, SO2, O3). Due to the reduced size, weight, and prize, WoePal is in a unique position to produce wearable, low-power consuming gas analysers with unrivalled performance. Using wireless communication protocols, each person wearing such a device can be converted into a mobiles gas-sensing node. Based on this basic sensorial hardware, WoePal plans to use sensor network technology to develop an innovative, transferable solution to a number of industrial, scientific and societal challenges by providing high quality, ground truth information about GhG fluxes and concentrations. The innovation associate's objective is therefore to extend current hardware capabilities and sensor knowledge at WoePal UG to enable and provide additional services where the measurements are combined with modelling to deliver solutions which are tailored to the needs and demands of users.

Keywords: gas sensor network