Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of a bioengineered basement membrane to enhance the performance of blood-contacting devices (HemoStratum)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-04-01
End date: 2027-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Each year, over 10 million of transitory and permanent blood-contacting devices are implanted worldwide, playing a crucial role in addressing cardiovascular diseases and providing life-sustaining support. However, despite their widespread use, sub-optimal biocompatibility still represents a major challenge, compromising safety, efficacy, and durability. Up to 70% of patients experience device-related hemocompatibility issues, significantly affecting their quality of life. To mitigate these risks, antithrombotic drugs are commonly prescribed, yet these systemic treatments come with severe complications, including postoperative bleeding, stroke, and hemorrhage. To address these limitations, material surface modification strategies have been explored to improve the hemocompatibility of blood-contacting devices, with a particular emphasis on promoting stable endothelialization. Among these approaches, physical modifications, such as surface patterning, are considered superior to biological and chemical functionalization because they offer a long-lasting performance, without degrading or losing functionality over time, unlike conventional surface coatings. Despite the continued interest from both industrial and academic research, there are no clinically available bioengineered substrates that integrate mesoscale and microscale surface features able to promote and maintain stable device endothelialization that can ensure long-term resistance to thrombus formation. In this proposal, we aim to optimize and validate HemoStratum, a bioengineered substrate fabricated by our proprietary processing technology. By integrating electrodeposition and photolithography, HemoStratum leverages on both microfibers and meso-patterns identified to promote endothelial cell proliferation and structural organization. This notion represents a radical innovation that can enhance hemocompatibility of a broad spectrum of blood-contacting devices while ensuring long-term stability, and durability.
DEVELOPING TRUSTWORTHY ARTIFICIAL INTELLIGENCE (AI)-DRIVEN TOOLS TO PREDICT VASCULAR DISEASE RISK AND PROGRESSION (VASCUL-AID)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,Serbia,Norway,Germany,United Kingdom,Portugal,France,Finland
Call: Trustworthy artificial intelligence (AI) tools to predict the risk of chronic non-communicable diseases and/or their progression (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-05-01
End date: 2029-04-30
Duration (months): 72.0
Total project cost (EUR): 5969125.0
EU funding (EUR): 5969125.0
Participants: 16
Project status: SIGNED

The aim of VASCUL-AID is to predict the risk of cardiovascular events and progression of the vascular diseases Abdominal Aortic Aneurysm (AAA) and Peripheral Arterial Disease (PAD) to influence the course of disease improving the patient’s quality of life and care and assisting clinicians to make better-informed decisions involving the patient. VASCUL-AID will allow us for the first time to identify patients who are at high risk for AAA growth or PAD progression and cardiovascular events. To this end, we will deliver a clinically relevant and cost-effective trustworthy AI-driven platform (VASCUL-AID) that integrates multi-source parameters including imaging, proteomic and genomic data as well as life-style patient data from wearables to enable personalised vascular disease management. To maximise the personalised prevention strategies, VASCUL-AID leverages visualisation tools to improve clinician-patient communication and empower the patient. The VASCUL-AID platform consists of AI risk-prediction tools, a patient communication app an a clinical dashboard to support clinical decision-making. A particular emphasis is placed on ethics, to ensure beneficial implementation of AI prediction tools. In this project, we aim to (1) build an EU-wide data infrastructure, (2) develop an AI-based progression prediction tools for AAA and PAD, (3) develop criteria according to the COMET initiative to assess the effectiveness of VASCUL-AID, and (4) clinically test and show proof-of-concept for the VASCUL-AID platform. Once validated, this platform can be extended to other cardiovascular diseases (CVDs) as well. VASCUL-AID brings together 14 leading organisations (and 2 affiliated entities) consisting of clinical academic centres, institutes, universities and SMEs as well as large industry, patients organisations and policy makers that cover the full value chain to enable integration of the platform into clinical practice.

Keywords: vascular diseases abdominal aortic aneurysms peripheral arterial disease personalised medicine
Finite-state abstractions of infinite-state systems (FINABIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1482500.0
EU funding (EUR): 1482500.0
Participants: 1
Project status: SIGNED

The algorithmic analysis of infinite-state systems is a central topic of theoretical computer science that is part of a popular approach to software verification. While analyzing infinite-state systems is indispensable when verifying software, finite-state sytems are far better understood and permit much more efficient analysis. In this project, I will pursue fundamental questions that arise when we want to abstract infinite-state systems by finite-state systems. The goal is to understand two types of problems: 1. Separability problems: Given two infinite-state systems, can we find a finite-state overapproximation of the first system whose behaviors are disjoint from those of the second system? Separability is a basic task for synthesizing certificates for disjointness and therefore safety properties in concurrent systems. 2. Closure computation. There are several non-constructive results that guarantee the existence of finite-state overapproximations of infinite-state systems that preserve some particular information. We are interested in how to compute these overapproximations effectively and efficiently. Examples include downward closures and upward closures with respect to the (scattered) subword ordering. Efficient procedures for closure computation would have immediate implications for infinite-state verification tasks that combine recursion with concurrency. In addition to directly attacking well-known deep open problems regarding these fundamental questions, the project will also develop methods that will likely be crucial for resolving further major open problems in infinite-state systems. Moreover, the obtained results would have immediate implications for software verification in settings that combine recursion with concurrency, which is a notoriously difficult task.

Keywords: software verification,decidability,complexity,algorithmic analysis
Exoplanetary Systems with a Coronagraphic Archive Processing Engine (ESCAPE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2028-08-31
Duration (months): 72.0
Total project cost (EUR): 1999996.0
EU funding (EUR): 1999996.0
Participants: 1
Project status: SIGNED

Determining the frequency of life in the Universe is one of the main challenges of the next decades. It requires a large high-contrast imager in space such as LUVOIR or HabEx, able to characterize dozens of nearby earth-like planets. The detection of such planets, 10^-10 fainter than their star and lost in the bright and varying glare of the star in the images, is a formidable challenge. In the race to remove the contaminating starlight, both the coronagraphic instrument and the image processing have a key role to play. Yet, the science and technological definition of these mission concepts relies entirely on the coronagraphic instrument to reject the starlight, assuming a simple gain of 10 in sensitivity with image processing based on 15-year-old techniques developed for HST. The cost of this approach is a daunting wavefront stability requirement of 20pm rms and conservative exoplanet yield estimates. With ESCAPE I propose to develop innovative image processing methods that make use of the specific hardware in these high-contrast imagers (their wavefront sensors and deformable mirrors) and of the data accumulated in their archives to bring a significant gain in starlight subtraction. I will use the unique opportunity of the timely launch of the Roman Space Telescope during the ERC timeframe, which precisely includes the CGI technology demonstrator of high-contrast imaging in space, to demonstrate my methods and achieve 20x improved detection limits. In parallel I will deploy the ESCAPE methods on the public archives of the VLT-SPHERE and JWST NIRCam and MIRI coronagraphic instruments to deliver higher-grade data to the community, obtain new planetary systems discoveries, and constrain the giant planet population on scales yet-unexplored and comparable to the Solar System. These ambitious goals and timeline will pave the way for the implementation of the ESCAPE methods in the future space imaging missions and facilitate the determination of the frequency of life.

Keywords: direct imaging high contrast imaging image processing data analysis
MEDIATED BIPHASIC BATTERY (MeBattery)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Austria,Portugal,Germany
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-05-01
End date: 2025-10-31
Duration (months): 42.0
Total project cost (EUR): 2508694.0
EU funding (EUR): 2508694.0
Participants: 6
Project status: SIGNED

Energy Storage Systems (ESSs) have become key elements for achieving a sustainable energy and transportation system. Among the EESs, different battery technologies hold great promises for enabling the necessary transition from fossil fuels to renewable sources. However state-of-the-art flow (All-Vanadium and Zinc – Br2) and static (Na-ion and Li-ion) battery technologies fail to satisfy all key performance indicators, e.g. sustainability, cycle life, recyclability, energy and power decoupling, cost or energy density. The overall objective of the MeBattery project is to lay the foundations of a next generation battery technology, which will overcome critical limitations of state-of-the-art battery technologies exhibiting an excellent balance among these key performance indicators. The radically new vision of this novel battery technology relies on a combination of unconventional thermodynamically-driven concepts that will lead to a paradigm shift in energy storage. The proposed new battery technology relies on a flowing configuration system that i) possess the intrinsic benefits of flowing systems (energy conversion reactor separated from energy storage reservoir), ii) boost the energy density by storing energy in solid materials confined in the external reservoirs, and iii) guarantee the stability of the systems over long periods of time by using immiscible liquids. Using the complementary expertise of the highly qualified partners of MeBattery consortium (including 3 ERC awardees) in computational science, materials science, organic chemistry, environmental chemistry, chemical engineering, electrochemistry and battery prototyping, the final prototype aims to demonstrate a long-life, safe and eco-friendly flow battery technology based on non-critical materials with an energy density of > 60 Wh L-1, projected lifespan of 10.000 cycles, energy efficiency of > 75 % and thermal stability up to 50 ºC.

Keywords: electrochemistry energy storage battery biphasic systems
Solar To Value (SolVa)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: SIGNED

To combat global warming, achieving net-zero or net-negative CO2 emissions is imperative. The EU, aligning with the Paris Agreement, aims to reduce emissions by 40% and increase renewables share to 32% by 2030. Another challenge that the globe faces is the massive accumulation of PET plastic waste, prompting the EU to seek innovative recycling solutions. Solar-powered photoelectrochemical systems offer a clean, cost-effective alternative by converting CO2 into fuels while simultaneously recycling PET waste into high-value products. Moreover, by integrating PET oxidation, it aims to overcome the substantial overpotential loss associated with conventional oxygen evolution reactions at photoanode, making the process more efficient. Therefore, Solar-to-Value (SolVa) missions to develop a co-planar photocathode-photoanode architecture based on halide perovskites, creating an interdisciplinary solution for an efficient PEC CO2R-PET oxidation system. To facilitate these processes, advanced and selective electrocatalysts: Fe and Cu single atoms on N-doped carbon catalysts for CO2 reduction and NiFe-based catalysts for PET oxidation, will be integrated into the photocathode and photoanode, respectively. To ensure the stability of the perovskite-based photoelectrodes, protective layers of ITO will be deposited, preventing direct contact of thin-films with the electrolyte. The successful realization of this project holds the promise of developing standalone monolithic PEC cells for CO2R-PET oxidation. This can also extend the anodic recycling process to PV modules/spent Li-ion batteries and integrate it with cathodic CO2R through proper modifications of electrocatalysts and electrolytes. SolVa addresses two pressing global issues in a single innovative system, ultimately promoting a sustainable and circular economy.

Keywords: photoelectrochemical cells,co2 reduction,plastic recycling,pet oxidation,electrocatalysis,single atom catalysts,photovoltaics,solar fuels,integrated energy conversion systems
CREATING FRAMEWORK CONDITIONS FOR RESEARCH MANAGEMENT TO STRENGTHEN THE EUROPEAN RESEARCH AREA (RM ROADMAP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Belgium,Hungary,Portugal,Netherlands,Ireland,Cyprus
Call: Towards a Europe-wide training and networking scheme for research managers (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1499997.0
EU funding (EUR): 1499997.0
Participants: 8
Project status: SIGNED

RM ROADMAP (Creating Framework Conditions for Research Management to Strengthen the European Research Area) will create a roadmap for the future of research management (RM) in Europe and a community to support its delivery. To enhance access to excellence, the overarching objective of RM ROADMAP is to identify and adapt the research management capital base of the EU, including the widening countries, of its current and future research management workforce to emerging needs to improve the EU's competitiveness and sustain its economic performance. The RM ROADMAP consortium is proposing a state-of-the-art pan-European network of research managers, supporting the establishment of strategic, cross-border partnerships between research managers in industry, Research Funding Organisations, higher education and research institutions. RM ROADMAP will connect existing European networks on a smart community platform which will enable an unprecedented co-creation process in research management in the world. This co-creation process will gather the existing communities and expand upon them to reach two main objectives: 1. create and inform a bottom-up consensus on the future of RM in a roadmap and 2. inform the community about existing training, networking, funding and mobility opportunities. RM ROADMAP consists of 8 partners: European Association Of Research Managers And Administrators (Belgium); HETFA Research Institute (Hungary); Nova University Lisbon (Portugal); Association Of European Science & Technology Transfer Professionals (Netherlands); Crowdhelix Limited (Ireland), The Cyprus Institute (Cyprus) and associated partners Janssen & Janssen and Una Europa (Belgium).

Keywords: research support,rma,rm training,rm career path,job roles,professional recognition,networking,rm skills,rm capacities development
Advanced Modeling of Pulsar Emissions at Radiowaves (AMPER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 1
Project status: SIGNED

Magnetospheres of neutron stars (NSs) represent unique plasma-physics labs of extreme environments characterized by ultra-high magnetic field strengths, relativistic processes, and the presence of quantum electrodynamic effects – parameters far unreachable on the Earth. Detailed information on these processes comes to us via coherent radio emissions of pulsars and possibly fast radio bursts (FRBs), being observed by fast-developing sophisticated instruments of radio astronomy like FAST, CHIME, ALMA, and in near future, SKA. However, no agreement has been reached on their exact coherent radio emission mechanism that can interpret the observations, mainly because the modeling of the radio emissions requires operation of the extreme-physical processes and simultaneous consideration of the wave coherency at plasma kinetic micro-scales. This project addresses the question of which specific mechanisms are responsible for coherent radio emissions of NSs; in detail, which qualitative radio emission properties of pulsar pair-creation events and propagating kinetic Alfvén waves in the magnetospheres of NSs can lead to the interpretation of pulsars and transient events like fast radio bursts. The mechanisms will be investigated by combination of my expertise in first-principle particle-in-cell simulations of the micro-kinetic instabilities with the long-term experience in advanced dispersion and coherency analyses of radio waves in the simulations at the host institute. This combination of skills will allow me to make predictions on coherent properties of radio waves in terms of their total power, luminosity spectrum, its directivity and polarization as they escape the emission sources. I will distinguish, for the first time, how the extreme plasma instabilities lead to the coherent and incoherent radio emissions of pulsars and FRBs. After the project, the obtained properties can be utilized in radiative transfer codes to get specific predictions on NS radio observables.

Keywords: pulsars,fast radio bursts,neutron stars,radio emission mechanisms,particle in cell kinetic simulations,space plasma simulations,plasma astrophysics
Transport resilience against Cyber and Non-Cyber Events to prevent Network Disruption (TRANSCEND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Resilient Infrastructure
Action type: Innovation actions
Countries involved: Luxembourg,Italy,Spain,Belgium,Ireland,Hungary,Greece
Call: Supporting operators against cyber and non-cyber threats to reinforce the resilience of critical infrastructures (HORIZON-CL3-2023-INFRA-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 5067273.81
EU funding (EUR): 4378953.54
Participants: 21
Project status: SIGNED

The transport network is among the so-called Critical Infrastructures' (CIs), which are essential to maintaining the vital functions of the Single Market. While it is by nature a large-scale interconnected and interdependent system to efficiently move people and goods, its complexity also makes it more vulnerable in the event of a disruption and generates economic impact on a European scale. Due to the increasing cross-border interdependencies between services provided using critical infrastructures in these sectors, an interruption in one MS may have implications in other MS or in the Union as a whole. In December 2022, Council Recommendation 2023/C 20/01 suggested giving priority to four of the eleven sectors mentioned in the CER Directive, including transport. Although transport is recognised as a key sector to be protected, freight transport is underrepresented in terms of previous research projects. As supply chains become more complex and global, they rely more on logistics infrastructures that must be resilient to provide seamless transport. Since freight transport terminals are locations where goods are assembled and dispersed, they have always been a focus of security and safety concerns. The overarching objective of TRANSCEND is to provide freight transport critical infrastructure operators with an integrated set of advanced tools, guidelines and technological solutions to reduce risk, and enhance the protection and resilience of their critical infrastructure and interrelated critical infrastructures against physical, cyber and hybrid threats.​ The contributions will be integrated into a Control Tower, a digital platform with embedded business intelligence giving stakeholders a shared and continuous visibility of threats and risks by breaking down silos within and between organisations. To demonstrate the effectiveness of the approach, five diverse CIs will experiment methodological and technological solutions as pilots: three leaders and two followers.

Keywords: resilience,policy and support,cyber and non cyber threats