Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Disruptive platform for sustainable and low-cost amino acid production (BioBAA)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Denmark
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-12-01
End date: 2023-05-31
Duration (months): 30.0
Total project cost (EUR): 2945306.0
EU funding (EUR): 2061714.2
Participants: 1
Project status: SIGNED

Serine and Cysteine are two commercially important AAs. However, both present severe limitations regarding their production’s environmental and economic sustainability, which limits their market potential and causing a large negative environmental impact. Supported by advanced patented-metabolic engineering and synthetic biology approaches Cysbio developed a bio-based platform for AA production - AA-Platform - with an unprecedented environmental and economic performance. Through the design of proprietary cell factories (Escherichia coli), Cysbio was able to combine, balance and tune the different metabolic pathways involved in Ser production. The accomplishment of the AA-platform performance is also due to: i) the sustainable and cost-efficient bioconversion of Ser into Cys; ii) efficient and multi-sourced (i.e. can use sources of glucose, maltose or glycerol with limited impact on process’s efficiency); and iii) sustainable upstream and downstream processes. Building from these strong value propositions, this innovative platform yields a significant advantage against competitors’ products and will radically change the market, by creating the cheapest AAs (Ser<2.1 €/Kg and Cys<2.5€/Kg and longer term the target is >1 €/Kg and >2 €/Kg respectively) and in an environmentally sustainable manner. This will allow companies and society at large to replace fossil-based, energy consuming and polluting processes and products with sustainable, bio-based alternatives. Cysbio is currently a small and agile company, whose business strategy is to move quickly into the market by taking a large share of the existing Ser and Cys market segments and by creating a new one, replacing part of Met added in the chicken feed (with a market size of 5.4€Bn) with our sustainable and inexpensive Cys. The BioBAA project is at the core of this strategy and is what drives the company´s mission and future activities for a successful development.

Keywords: biobased amino acids,renewable feedstocks,serine,cysteine,cell factory,new cost reference
Tracing novel androgen pathways: deciphering the role of 16α-hydroxylation in human fetal biology (SHOXY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Steroid hormones, produced by the fetal adrenal, are metabolised by the fetal liver and placenta thereby regulating fetal development. Consequently, these steroids are also implicated in endocrine-related disorders and diseases that present in the fetal and neonatal stage. The major fetal liver cytochrome P450 enzyme, CYP3A7, catalyses the production of 16α-hydroxy-dehydroepiandrosterone (16α-hydroxy DHEA) leading to the biosynthesis of the 16α-hydroxy estrogen of pregnancy, estriol, in the placenta. This 16α-hydroxylation is also mediated by CYP3A4 in neonates, as a switch from the predominant CYP3A7 to CYP3A4 expression occurs after birth. Both enzymes, together with CYP3A5 (expressed in adult livers) are capable of hydroxylating steroid substrates on C16 producing metabolites in the fetal and neonatal stages. Importantly, the major adrenal steroid, 11β-hydroxyandrostenedione (11OHA4), a C11-oxy androgen, is produced in the fetal adrenals and circulatory levels have been quantified at birth. The chemical structure of 11OHA4, possessing no moiety on C16, allows it to be hydroxylated by CYP3A enzymes —producing novel downstream 16α-hydroxylated metabolites. While the contribution of 16α-hydroxy DHEA to fetal biology has been widely reported, the contribution of 16α-hydroxy C11-oxy androgens has not, to date, been characterised. Moreover, these metabolites have not been structurally identified. I hypothesise that C11-oxy androgens are catalysed by CYP3As, producing novel 16α-hydroxy C11-oxy androgens in the liver and the placenta. State-of-the-art high-resolution mass spectrometry platforms will be utilised to identify these novel metabolites and confirm the hypothesis. Significance of the proposed study: This project will advance our current knowledge on the downstream metabolism of the C11-oxy androgens and will characterise a novel steroid pathway in fetal biology, potentially important in human development in health and disease.

Keywords: steroid hormones,cytochrome p450 cyp enzymes,fetal liver cyp3a7,bacterial expression systems,enzymatic assays,liver steroid metabolism,high resolution mass spectrometry
Enforcement of the environmental regulations on sulphur emissions from ships using drone technology. (Project Sense)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Denmark
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Explicit I/S is seeking phase 1 funding in order to assess the commercial feasibility of Project Sense ― a drone technology system to monitoring sulphur emissions from ships during cruise. Project Sense is aimed at offering a cost-efficient, highly scalable solution in answer to the urgent demand by enforcement authorities (= customers) for technologies to enforce the international restrictions on ship sulphur emissions in force from 1 January 2015. On this date, the allowed sulphur limits in North European and North American waters will be reduced by 90 % resulting in a dramatic increase in fuel costs for ships operating in these areas. If not effectively enforced, the change threatens to create a devastating competitive disadvantage to those operators - many of them European - who comply with the rules. Creating a difference in market pricing of up to 25-30 % the temptation to keep burning high sulphur fuel will be enormous. But ship emissions are hard to monitor and existing sampling technologies are limited and very costly to deploy. Project Sense solves the enforcement challenge by using smart, self-guided drones programmed to intelligently seek out the ships at sea, sample the plumes using onboard sensors, and transmit the compliance results back in real-time. Based on low-cost hardware components tied together by an advanced software platform proprietary to Explicit I/S, Project Sense presents a highly competitive enforcement alternative to the authorities in Europe and globally. The feasibility study is intended to assess the commercial viability and marketability of the prototype system. In particular: The regulatory requirements needed to operate autonomous drones in the key markets; optimising the software for smart flight and establishing key operational parameters; verifying the appropriate business model; and exploring grounds for extended IPR. The study will lead directly to a Phase 2 application to take the project into scale.

Keywords: drone,sulphur,sulfur,emission,ship,emission limits,limits,enforcement,marpol,eu sulphur directive,smart flight,sniffer,sampling,monitoring,autonomous,compliance,competition
Inlet PArticle Separator Numerical ExperiMental Assessment (IPANEMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Belgium,Belgium
Call: Experimental & Numerical analysis dedicated to FOD Management for Turboprop Air intake (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-06-01
End date: 2022-02-28
Duration (months): 57.0
Total project cost (EUR): 949337.5
EU funding (EUR): 949337.5
Participants: 2
Project status: CLOSED

IPANEMA is a joint numerical and experimental undertaking to understand and improve the separation efficiency of inertial particle separators (IPS), which are integrated in the intake to protect turboprop engines from the ingestion of dust particles and water. The project first focuses on the numerical and experimental tools used for this type of studies and design. Based upon a complementary detailed experimental and numerical study using Large Eddy Simulation of simplified geometries, representative of the IPS and the intake, practical design tools will be developed and calibrated and integrated into an automated design chain. Subsequently, a full configuration will be studied both experimentally and numerically, in order to assess the design, investigate geometrical sensitivities and suggest geometrical optimisations. During the course of the project, new numerical and experimental techniques will be developed. Together with a detailed reference validation database on simplified geometries, these improved techniques will provide a significant contribution to future scientific research on particle separators and particulate flows in general.

Keywords: turboprop intake,inertial particle separators,particulate flows,rans,model calibration,optimisation
Surviving extinction: traits encouraging survival at times of stress (SurE-TESTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Understanding the response of marine organisms to future global warming, and associated changes such as acidification and oxygenation, is difficult to evaluate based on modern observations alone. This uncertainty will be addressed by studying the fate of marine organisms during the warmer-than-present climate of the Triassic – an interval marked by several major extinction crises attributed to such factors. A major database of species and genera ranges will be constructed for selected groups showing varying susceptibility to stressors alongside a proxy database of environmental variables. I will assess patterns in this dataset using state-of-the-art subsampling and residual modelling techniques and GIS-based packages to reveal the selective roles of kill factors. By allowing me to work in one of the main mass extinction research centres in Europe, alongside Professor Paul Wignall, the fellowship will allow me to become established as a major international researcher. I will bring complementary taxonomic and geochemical skills to the Leeds, which will greatly contribute to this research group and also strengthen their links with my home institute in China, the major geosciences university at Wuhan, thus placing Europe at the forefront of research on key environmental issues concerning ocean stresses.

Keywords: extinction,palaeontology,ocean acidification,ocean anoxia
Mechanisms of epigenetic inheritance by short RNAs (RNAEPIGEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-02-01
End date: 2021-07-31
Duration (months): 66.0
Total project cost (EUR): 1791250.0
EU funding (EUR): 1791250.0
Participants: 1
Project status: CLOSED

Epigenetic mechanisms are considered to be central to the development of multicellular organisms made of different cell types, all having identical genomes. Similarly, they may explain how genetically identical organisms are capable of adapting to distinct environmental conditions. Yet, the molecular mechanisms regulating how epigenetic traits can be inherited during cell division or across generations are not fully understood. Using the nematode Caenorhabditis elegans, we have recently revealed how the nuclear Argonaute protein CSR-1 and its associated short RNAs participate in global transcriptional regulation and chromatin organization. This unprecedented observation opened up a new class of molecular mechanisms by which Argonaute proteins and their bound short RNAs may actively contribute to epigenetic inheritance in animals. This research proposal focuses on the characterization of short-RNA-based mechanisms of epigenetic inheritance during animal development and upon environmental changes. Using C. elegans as an animal model system, we plan to integrate genetic, biochemical, and molecular biology tools with high-throughput genomic and proteomic approaches to dissect (i) the molecular mechanism by which CSR-1-bound short RNAs regulate transcription, (ii) test their ability in propagating the memory of actively transcribed genomic regions during early embryonic development, and (iii) characterize their role in propagating the memory of stress responses across generations to facilitate the adaptation of animals to environmental changes. Given the association of nuclear Argonaute proteins with transcriptionally active loci in metazoans, we anticipate that similar CSR-1-like epigenetic functions are also conserved in humans. Therefore, our research has the potential to significantly advance our understanding of the molecular mechanisms underlying epigenetic inheritance and reveals their impact on animal development and adaptation to changing environments.

Keywords: short rnas,small rnas,sirnas,endo sirnas,rnai,rna silencing,epigenetics,transcriptional regulation,rna biology,chromatin,histone modifications,c elegans,epigenetic inheritance
Dissecting the role of the ubiquitin proteasome system in the pathogenesis and therapy of B-cell malignancies (BCM-UPS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 1973255.0
EU funding (EUR): 1973255.0
Participants: 1
Project status: CLOSED

B-cell malignancies are characterized by high levels of genomic instability, which critically contribute to their pathogenesis and evolution. Recently, the fundamental role of the ubiquitin proteasome system (UPS) in maintaining genome integrity has been appreciated. Two major new therapeutic modalities in B-cell malignancies, proteasome inhibitors and imunomodulatory drugs (IMiDs), target the UPS and demonstrate particular efficacy in multiple myeloma (MM) and mantle cell lymphoma (MCL), two incurable entities with poor prognosis. This suggests the presence of aberrant ubiquitylation events, whose identities have however remained mostly elusive. Our recent studies identify fundamental roles of orphan ubiquitin ligases of the Cullin Ring ligase family (CRLs) and their counterparts, the deubiquitylating enzymes (DUBs) in the cellular DNA damage response machinery, and characterize these candidates as novel oncogenes or tumour suppressors in MM and MCL. These findings provide the foundation for our hypothesis that deregulated ubiquitylation events involving CRLs and DUBs have a far reaching impact on the pathogenesis of B-cell malignancies and can serve as new therapeutic targets and biomarkers. We therefore propose a multistep strategy in which we will (1) characterize previously orphan CRLs and DUBs, which we have distinguished as candidate oncogenes and tumour suppressors in MM (FBXO3, USP24), MCL (FBXO25), or MM and MCL (CRBN), respectively; (2) decipher the global role of CRLs and DUBs in MM and MCL using defined genetic screens; (3) identify relevant substrates of CRLs/DUBs discovered in (2) using mass spectrometry; and (4) validate CRL/DUB candidates in preclinical mouse models and defined patient cohorts as to their disease relevance. We expect that our interdisciplinary approach will unravel the overall role of the UPS in the pathophysiology, evolution and treatment of B-cell malignancies.

Keywords: b cell malignancies,ubiquitin proteasome system
Field driven materials for functions, dissipation, and mimicking Pavlovian adaptation (DRIVEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

During the recent years, biological materials have extensively inspired materials scientists towards new properties, e.g., for composites, photonics, and wetting. The future grand challenge is to mimic biological active materials towards new properties that commonly have not been connected with man-made materials. Due to the biological complexity, conceptually new approaches are needed in materials science. In the project DRIVEN, field-driven dissipative out-of-equilibrium self-assemblies are developed in the colloidal and molecular scale. In the proposal, instead of using chemical fuels to drive dissipative self-assemblies, which is ubiquitous in Nature, imposed fields are here used to drive the system out-of-equilibrium towards new assemblies and functions. The project show steps with growing risks towards highly ambitious new materials mimicking aspects from active biological materials.

Keywords: dissipation,cognitive materials,responsive materials,pavlovian conditioning
Themistius, Heavens and Elements. Interpretations of Aristotle’s Cosmology Across the Ages (THEIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

THEIA is the resubmission of the project “Themistius, Heavens and Elements. Interpretations of Aristotle’s Cosmology Across the Ages” that has received the Seal of Excellence 2019. THEIA is a project on the paraphrase of Aristotle’s De Caelo by the 4th century rhetor and philosopher Themistius. It aims to shed light on Themistius’ presentation of the Aristotelian cosmos, that is contained chiefly in this paraphrase. Its importance in the history of Aristotelianism is beyond doubt, as it is the first complete exegesis of the De Caelo that has come down to us, but adequate study of it has been hampered by the fact that the original Greek is lost: only a medieval Hebrew version of the lost Arabic version, and in a Hebrew-into-Latin version survive. Both are edited, but the Latin is derivative, and the Hebrew text requires a new critical edition. THEIA will edit, translate into English, and comment upon the Hebrew text. Once the task accomplished, this will allow the scholars in the field to get a more complete picture of 4th century Aristotelianism. To the importance of THEIA for the history of philosophy another reason of interest should be added, that concerns the text of Aristotle. The Hebrew version allows the scholar who is conversant with Themistius’ exegetical habits to reconstruct some passages in the Greek original, and to single out the Aristotelian lemmata of the De Caelo interspersed in Themistius’ wording. The retroversion of these lemmata into Greek will provide the philologists with an extremely important piece of documentation: parts of the text of Aristotle’s De Caelo as it was read in the 4th century, i.e. five centuries before the most ancient ms of it. In this sense, THEIA can be considered an interdisciplinary project that, through the reconstruction and interpretation of a Greek work transmitted in Hebrew and Latin, paves the ground to a fruitful cooperation of philosophical and philological skills.

Keywords: aristotelian tradition,late antique philosophy,arabic philosophy,medieval philosophy,jewish,thought,renaissance,early modern thought