Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
General characterisation of near term quantum advantage regimes (ENCHANT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-03
End date: 2027-03-02
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Quantum computing is a very rapidly developing field with the potential to address problems that were considered intractable some decades ago. Despite the daunting technological challenge, quantum devices have reached a size for which their calculations cannot be fully simulated by classical computers. Nevertheless, noise and short coherence times hinder their actual performances, and the algorithms with proven quantum advantage will not be implemented soon. This intermediate scenario opens exciting avenues and poses several challenges. How to systematically identify tasks where a quantum advantage over classical computers can be obtained in the near term? Once they are found, how to certify that the same computation cannot be reproduced by any classical means? ENCHANT, gENeral CHAracterisation of Near-Term quantum advantage regimes, proposes a radically new vision: the development of a comprehensive toolset to characterise the remarkable realm of near-term quantum advantage regimes. The toolset is meant to provide three fundamental assets for such an ambitious task: (A) a general framework encompassing the algorithms that can be run in current devices, compatible with their main limitations and constraints. We envision to obtain that by means of a careful classification of the families of states that can be obtained as the output of near-term quantum computation, (B) an assortment of task-tailored classical algorithms to simulate the performances of quantum devices. Here the interest is two-fold: to provide comparative methods to assess the quality of those devices and to identify tasks with no quantum advantage over classical computers, (C) a selection of techniques to certify quantum effects in computation and relating them to the hardness of simulating the same task classically. To make them amenable for quantum advantage regimes, we look for methods that rely on partial information about a quantum system.

Keywords: quantum computing,tensor networks,quantum information
Engineer Architecturally Heterogeneous Multi-material Multi-principal Element Alloy Composites for Cryogenic Applications (E-AH-MMEAC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-03
End date: 2027-07-02
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Architecturally heterogeneous multi-material multi-principal element alloy (MPEA) composites represent a unique class of heterostructured materials with great potential to evade the strength–ductility trade-off dilemma. However, most conventional processing routes involving high temperatures (e.g., casting, additive manufacturing, and powder metallurgy) suffer from various metallurgical issues such as excessive elemental diffusion, segregation, hard intermetallic phase formation, cracking, and poor densification. To mitigate these challenges, the project suggests prefabricating various MPEA powders into billets using cold spraying (CS) and then employing solid-state friction stir processing (FSP) to achieve microstructural densification. This approach will initiate various dynamic recrystallizations in different compositional domains, allowing us to engineer architecturally heterogeneous multi-material MPEA composites. In general, this project will be implemented in phases, including optimizing process, controlling the heterostructure, evaluating mechanical performances from ambient to cryogenic temperatures, and elucidating deformation mechanisms. The results can be expected to build up the “processing–microstructure–mechanical behavior” correlations of the newly developed multi-material MPEA composites in a quantitative manner. This will facilitate the design and fabrication of similar heterostructured composites, thereby impacting a wide range of industrial sectors, e.g., transport, defense, nuclear, and manufacturing.

Keywords: multi metal composite multi principal element alloy cold spraying friction stir processing microstructure evolution mechanical properties
Just knowledge co-creation for a regenerative Arctic economy (ArcticKnows)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Finland,Iceland,Sweden,Greenland,Norway,Denmark,United Kingdom
Call: Participation and empowerment of Arctic coastal, local, and indigenous communities in environmental decision-making (HORIZON-CL6-2024-COMMUNITIES-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 2927741.17
EU funding (EUR): 2809495.63
Participants: 8
Project status: SIGNED

ArcticKnows will empower Coastal, Local and Indigenous Communities (CLICs) in the Arctic to mobilise their indigenous and local knowledges (including traditional ecological knowledge) and enhance their agency to act towards co-creating regenerative economies and livelihoods in a just, inclusive, and gender-sensitive way. The project convenes CLICs, researchers and other local stakeholders (industry, businesses, civil society, policymakers) in a just and decolonial knowledge co-creation process, to co-design and co-deploy pioneering principles, methodologies, guidelines, frameworks and indicators for regenerative economies and livelihoods, as well as attractive platforms for community engagement and participation. ArcticKnows tackles some of the key challenges including a) climate change and climate related vulnerabilities; b) extractive economic models and mindsets; c) lack of recognition and/or—depending on the context—appropriation of local and indigenous knowledges; and d) lack of CLICs, women, and youth engagement in decision-making. It employs just, decolonial and inclusive knowledge co-creation and multi-actor collaborative and transdisciplinary approaches, for innovating and transforming towards regenerative and climate-wise economy, while co-designing platforms for meaningful community engagement that empowers and strengthen CLICs’, women, youth and other marginalized groups to participate in policy making. In ArcticKnows we cocreate, demonstrate and evaluate examples of regenerative local economies in four Pilots, in Greenland, Norway, Sweden and Finland, focusing on close-to-nature tourism, small-scale climate-resilient agriculture and climate-resilient fisheries, all of which represent environments of multispecies encounters. ArcticKnows advances and activates multispecies coexistence and justice. Finally, it promotes mindful sharing and scaling up best practices, while ensuring intellectual and cultural autonomy of local and indigenous knowledge holders.

Keywords: regenerative economy,environmental justice,more than human,coastal livelihoods,multi actor approach
Oxygen Optimization Therapy through BCPAP for management of childhood pneumonia in general hospitals of LMICs (OPT-bCPAP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: South Africa,Sweden,Nigeria,Ethiopia,Malawi
Call: Implementation research/real life assessment of existing interventions in women and children’s health (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 4641691.25
EU funding (EUR): 4641691.25
Participants: 7
Project status: SIGNED

Pneumonia is a leading cause of morbidity and mortality especially among children in sub-Saharan Africa. Nigeria and Ethiopia are among the 5 countries that account for half of the under-five pneumonia deaths. Majority of the deaths from pneumonia are however preventable with early diagnosis and appropriate management. In children with pneumonia, hypoxemia is quite common and constitutes a major risk factor for death. The WHO and other leading child health agencies urge widespread access to oxygen therapy. Bubble continuous positive airway pressure (bCPAP) is a method of delivering oxygen and positive pressure into the airways thus keeping the alveoli open for improved gas exchange. While use of bCPAP devices appears safe and effective worldwide, scaling of quality bCPAP devices in low- and middle-income countries (LMICs) has been limited. This has prevented most children in LMICs from receiving life-saving non-invasive respiratory support which could have saved many lives. Achieving Sustainable Development Goal (SDG) 3.2 of the reduction of under-5 mortality to at least as low as 25 per 1,000 live births by 2030 will likely not be possible without access to innovative and low cost interventions devices such as bCPAP in LMICs. The aim of the OPT-bCPAP is to perform context-appropriate scale-up of bCPAP in settings of very high disease burden (Nigeria, Ethiopia and Malawi) using the the positive results and the lessons learned from clinical trials conducted in Ethiopia, Bangladesh and Ghana. In addition to scaling up bCPAP, we will deeply explore additional factors associated with treatment failure and mortality from severe pneumonia, we aim to generate data on adherence to treatment guidelines, healthcare-seeking behaviour, magnitude of respiratory syncytial virus infection, antimicrobial resistance, PK/PD of commonly used antibiotics and generate novel recommendations for antibiotic treatments tailored to the populations in these diverse settings.
Ancient irrigation detection and analysis using advanced remote sensing methods (UnderTheSands)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-05
End date: 2024-09-04
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Ancient irrigation systems are probably the first human large-scale landscape modifications. The analysis of the ancient irrigation systems that gave rise to and sustained the first urban civilisations goes well-beyond the study of ancient irrigation to touch topics such as climate change, sustainability, population dynamics, and ancient economy, all at the core of urbanisation as a deeply human phenomenon, perhaps the most important change in the history of humanity. For many decades ancient water management research in archaeology was mainly focused on the Near East and surrounding regions with similar hydroclimatic conditions. The political situation in that region and, as a consequence, the lack of new data nearly stopped further scientific activities. The relevance of this research topic, however, did not decrease and many methods for the study of ancient irrigation and water management using remote sensing haven been developed during the last years. However, most previous approaches are region-focused (lacking applicability to other environments) and have mostly detected isolated channels, which complicates the study and understanding of the network that constituted ancient irrigation systems. UnderTheSands will employ a combination of novel remote sensing techniques (including Multi-Scale Relief Model, Seasonal Multitemporal Vegetation Indices, hybrid machine-deep learning algorithms, archaeomorphology, spatial correlation indices, and historical analyses) and sources (including multispectral imaging, synthetic aperture radar, and TanDEM-X) to produce a workflow for the detection and analysis of ancient irrigation networks in diverse environments. These methods and the training provided during their implementation by a team of leading international researchers will enhance the candidate's profile with cutting-edge techniques that will situate him at the forefront of research in ancient irrigation and boost his career.

Keywords: machine learning deep learning remote sensing,landscape archaeology ancient irrigation near east
ElectrOlysis of BIOmass (ELOBIO)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Estonia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 48.0
Total project cost (EUR): 397291.25
EU funding (EUR): 397291.25
Participants: 2
Project status: SIGNED

The ELOBIO project (EIC Pathfinder Challenge, 2023-2026) aims at advancing biomass electrolysis as a novel technological mean of green H2 production. ELOBIO will demonstrate that electrocatalytic oxidation of biomass-derived molecules offers the possibility to simultaneously reduce the energy cost and improve the chemical value of H2 production compared to the current water splitting technology. ELOBIO targets the development of low-temperature functional electrolysers capable of a large-scale production of H2 and value-added decarbonized chemicals, originating from the cellulosic biomass renewable exploitation. The project will design, build-up, test and improve a labscale prototype electrolysis cell at TRL4 involving a selective electrocatalytic cathode for the hydrogen evolution reaction and an electrocatalytic anode capable of selectively oxidizing biomass-derived compounds. Aldose-type sugars and furanic compounds were selected as model biomass for the validation of the concept. These molecules will be selectively converted to value-added chemicals. Furthermore, several emerging technologies rely on electrolysis assisted with an additional renewable source of energy (ultrasound, magnetic field) or coupled with the concept of electrochemical promotion of catalysis will be explored to further enhance the energy efficiency of ELOBIO electrolysers. The additional partner, the Baltic Innovation Agency (BIA), an Estonian SME, will help ELOBIO to strengthen the exploitation plan, long-term strategies and visibility of innovative ELOBIO electrolysers trough stakeholders mapping, value chain and market analysis and communication activities. In addition, BIA will promote the participation of stakeholders from Estonia and other Baltic states and will take part in the exploitation activities of the green hydrogen portfolio via the Buildit Accelerator, a Latvian based accelerator.

Keywords: biomass,electrolysis,green hydrogen,decarbonized chemicals,sustainability
Towards early cancer detection and tumor classification using epigenomic biomarkers in blood (EpiCblood)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 1499999.0
Participants: 1
Project status: SIGNED

Early cancer detection could increase curative treatment and long-term survival. Dying cells release small DNA fragments wrapped around a core of histone proteins into the bloodstream, so-called circulating cell-free nucleosomes (cf-nucleosomes). They carry DNA sequence information and histone modifications stable in blood, reflecting promising epigenomic disease biomarkers. But, the low proportion of cf-nucleosomes originating from cancerous cells versus the large background of nucleosomes arising from dying blood cells poses significant challenges for early cancer detection using circulating cf-nucleosomes. In EpiCblood, I will tackle these challenges and propose two complementary strategies to increase the number of “cancer-signature” cf-nucleosomes for cancer detection and tumor classification. In the first strategy, I will employ my previously developed synthetic histone modification readers to profile abundant histone modifications on cf-nucleosomes allowing me to seize up to 35 percent of the human genome non-invasively. I will prove this technology’s concept by detecting earlier stages of pancreatic cancer and simultaneously classifying molecular tumor subtypes. Furthermore, I hypothesize that tumorigenesis gives rise to cancer-specific genomic sites decorated with combinatorial histone marks, so-called “bivalent” regions, found explicitly in cancer and not in healthy adult cell types. In the second strategy, I will employ a computational pipeline to map cancer-specific bivalent sites across multiple cancer genomes. I will use my well-established combinatorial histone mark readers to test their diagnostic potential as cancer-specific biomarkers in blood plasma from healthy donors and cancer patients. My genomics expertise and proven technology provide an excellent basis for accomplishing the planned goals. EpiCblood will be a major step towards developing precise and rich liquid biopsy assays for multiple clinical applications in cancer management.

Keywords: liquid biopsy,cancer diagnostics,cancer predictive biomarkers,epigenetics,genomics
Advancing HeRitage science procedures for Depth-resolved condition risk assessment of wall paintings (HeRiDe)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1494881.0
EU funding (EUR): 1494881.0
Participants: 2
Project status: SIGNED

Although heritage science field already offers a wide range of tools for condition assessment of wall paintings, an efficient on-site full-field depth-resolved inspection is not achieved yet. In practice, heritage professionals often struggle to interpret complex and fragmentary scientific data. Conservators often face challenges in assessing hidden risks and localizing the depth of detected detachments, covered fresco layers, refills, and cracks. The main challenge in wall painting’s condition assessment is that it is inextricably linked to the architectural/archaeological support. The preservation of the pictorial layer, often unique and irreplaceable as in ancient frescoes, depends on the integrity not only of the surface but of the bonding substrate and the structure behind it. Informed and timely interventions by conservators are important to mitigate natural aging processes, and become crucial in case of extreme events (e.g. seismic activities, climate disasters etc.) or anthropogenic damage (both intentional and unintentional, including past restorations etc.). The HeRiDe methodology will be grounded in a scientific protocol that employs cross-correlation formulas to analyze full-field interferometric and thermographic datasets. This approach will differentiate hidden risks according to their characteristics and depth in the stratigraphy of wall paintings. The HeRiDe project seeks to exploit the maximum yet to be explored potential of the complementary full-field heritage science approach, testing and validating the results on wall painting mock-ups, and transposing the methodology to real case studies. To facilitate its real implementation, a dedicated open source software tool will be proposed to ensure broad access for all international heritage professionals. Finally, HeRiDe will enhance the accuracy of risk assessments and support more informed conservation decisions, contributing to the sustainable preservation of wall paintings worldwide.

Keywords: wall paintings,frescoes,conservation,heritage,non invasive diagnostics,deterioration,optics,physics,thermography,interferometry,shearography,digital documentation
Electric natural entryways (ENTER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The reach of biological electron transport (ET) increased from nm to cm with the discovery of cable bacteria that do ET via highly conductive fibres along their filaments. Their extremely long distance ET electrically connects 1000s of cells and influences redox cycling. Other bacteria interact with this electric highway via interspecies ET. A visual version: flocking, where aerobes use cables to breathe oxygen in its absence. Flockers dump electrons on intermediates, electron shuttles, which cables recycle. Since their discovery, cable bacteria sparked interest for green, biodegradable electronics. Flocking suggests that we can access the electric fibre without damaging it. Cables must have a natural electric entryway, to upload electrons from shuttles onto the fibres. ENTER aims to map this. We combine Prof Meysman's expertise on cable bacteria fibres with mine on flocker-cable bacteria interactions to: 1) Identify the electron shuttle by extensive electrochemical characterization of flockers (isolated in my PhD), map their ability to generate electricity, and find shuttle production potential in the genomes. 2) Advance models to find entryway protein sequences in closed cable bacteria genomes (from the host). 3) Localize the entryways on the filament and activate them using correlative light and electron microscopy with labelled shuttles and Raman microscopy. ENTER will provide new insights into the functioning of electric ecosystems and electric microbes. It will offer novel perspectives on redox and electron flow in natural systems. For example, oxygen breathing way beyond its presence will affect CO2 burying and sequestration in the seafloor. ENTERs impact, not limited to natural systems, will also inspire new insights for engineered systems (microbial fuel cells, contaminant biodegradation). It could provide critical stepping stones for promising alternatives in new green electronics. ENTER connects many disciplines, that it will influence and inspire.

Keywords: extra cellular electron transferring proteins,extra cellular electric interactions,electron shuttles