Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart Crystal Nucleation near Interface Dynamics in Active Pharmaceutical Ingredients (SMART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 313813.83
EU funding (EUR): 219669.68
Participants: 1
Project status: CLOSED

One of the most important challenges that drug development researchers face today is the low aqueous solubility of the active pharmaceutical ingredients (APIs). Most of the drug molecules under investigation exhibit poor water solubility and additional efforts are required to improve their solubility feature. Thus, the development of amorphous drugs is the most effective way how to improve the bioavailability of the APIs, and huge amount of effort is directed towards this smart approach. The aim of this project is to develop a reliable and universally applicable dynamic physio-chemical procedure for the description of the interconnection between the microscopic and macroscopic description of the triggered phase transformation – a task that would lay fundamental principles for the prediction of the macroscopic manifestation of the sub & near-Tg crystal growth in the class III amorphous drugs. This proposal is ‘SMART’ as this is first case of designing the unique green, dynamic and advanced molecular crystal nucleation near interface. In addition, the SMART project also aims to develop the combined experimental and mathematical procedural approach for fast, reliable, and accurate projections of the sub & near-Tg amorphous-to-crystalline dynamic transformation in amorphous APIs.

Keywords: amorphous solid dispersions smart solid state properties phase transformation amorphous drug molecules
LESSEN DATA ACCESS AND GOVERNANCE OBSTACLES (LAGO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Innovation actions
Countries involved: Italy,Spain,Portugal,Greece,Belgium,Finland,Sweden,Estonia,France,United Kingdom,Netherlands,Germany,Cyprus,Austria
Call: Improved access to fighting crime and terrorism research data (HORIZON-CL3-2021-FCT-01, 2021)
Start date: 2022-11-01
End date: 2025-04-30
Duration (months): 30.0
Total project cost (EUR): 7379298.75
EU funding (EUR): 6489798.75
Participants: 28
Project status: CLOSED

LAGO will deliver the foundation for a trusted EU FTC Research Data Ecosystem (RDE) to address the so-called “Data Issue” in the FCT research landscape, i.e., the lack of domain-specific data in sufficient quality and quantity to enable appropriate training and testing of the developed methods, platforms and tools. LAGO will be instrumental in identifying common barriers and subsequently providing the structural, governance and technical foundations to foster and innovate data-oriented research collaboration among LEAs, security practitioners, relevant EU agencies, academic and industry researchers, policy makers and regulators. For this purpose, LAGO will develop an evidence-based and validated multi-actor Reference Architecture for the FCT RDE for these actors to deposit, share and co-create data and tools for FCT research purposes based on common rules, protocols, standards and instruments in a trusted and secured environment. The envisaged Reference Architecture and accompanying governance framework will be based on the design principles of decentralisation, data sovereignty, data quality, openness, transparency and trust and comply with EU values and principles on data protection, privacy and ethics. The Reference Architecture will be accompanied by a TRL-7 Reference Implementation of added-value technological tools to ensure practical realisation of the Reference Architecture as multiple data spaces and across the full range of concrete usage scenarios. A Roadmap will finally provide the consolidated rules, conditions and considerations for the actual deployment of the EU FCT RDE. The ultimate ambition of LAGO is to go beyond the creation of a common repository in order to innovate the FCT data-oriented research sphere by creation the crucial foundations for the sustainable, safe and trusted creation, co-creation, sharing and maintenance of training and testing datasets for the FCT research domain.

Keywords: data spaces,trusted digital ecosystems
NGI0 Entrust (NGI0 Entrust)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Ireland,Spain,Belgium,Czechia
Call: Trust & data sovereignty on the Internet (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-08-01
End date: 2026-01-31
Duration (months): 42.0
Total project cost (EUR): 12499375.0
EU funding (EUR): 12499375.0
Participants: 11
Project status: SIGNED

NGI0 Entrust is a unique program to foster open source and open hardware solutions to pervasive privacy and data governance problems in internet technology. NGI0 Entrust leverages the proven successful NGI Zero program to fund internet research and development projects with a light-weight granting procedure and orthogonal support services to address internet-scale requirements. NGI0 Entrust extends this program to contribute to more trustworthy data management tools and decentralized identity management solutions by supporting a European ecosystem of top internet innovators, many of which we expect to be (groups of) individuals previously not funded by Horizon Europe-like R&D initiatives (NGI Zero has +95% grantees not previously funded by H2020). We expect to leave a lasting impact on the field of online data and identity security and privacy, because we can build on decades of experience to make this happen. What is unique about our program is that we provide an agile, effective and low threshold funding mechanism coupled with a greenhouse environment where funded projects in addition to receiving a grant are supported by world class domain experts in various fields, such as security, accessibility, license compliance, etcetera. The experts participating in NGI0 Entrust provide guidance and mentoring to tackle each of these topics and meet important requirements and needs of technologies on internet-scale. And to directly connect project output to decision makers, we can leverage our close ties to major constituencies: major standardization bodies (IETF, W3C, OASIS), the largest European open source community and open source licensing experts (FSFE), the digital rights and civil society actors (EDRi, EFF, Internet Society), the hosting companies (ECO), industrial and hardware representatives and gatherings (OSADL, FOSSI) and operational and technical intermediaries (Euro-IX, RIPE, CENTR, GÉANT, EuroISPA). Together, we can make a more trustworthy internet.

Keywords: open source trustworthy technology internet research and development ngi zero charitable grant privacy security data control user centric
Intelligent Real-time Elemental Analysis System (IREAS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Iceland
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 3490881.25
EU funding (EUR): 2443616.88
Participants: 1
Project status: CLOSED

IREAS, DTE’s “Real-time Intelligence from Liquid Metals Solution” combines DTE’s unique and only in the market proprietary chemical composition analysis based on Liquid-Phase Laser-Induced Breakdown Spectroscopy (LP-LIBS™) technology with a predictive AI-based cloud platform, engine of DTE’s metals intelligence ecosystem. IREAS converts elemental analysis data generated on the metals production plant floor into intelligence. This intelligence is not only supplied in real-time to management and operators on the plant floor for decision making, but is also fed back into the process and business systems for “forward-looking process control and business management“. The solution contributes to maximising value, sustainability, safety, and efficiency along the end-to-end value chain, for all stakeholders in the metals industry. DTE’s market target is the €3.5Trillion metals industry with initial focus on the aluminium (€255BN/y) while working towards the iron and steel market (€950BN/y).

Keywords: production technology,process engineering,machine learning and statistical data processing
LCTB-21: A DYRK1A protein kinase inhibitor for treatment of cognitive decline in Down Syndrome. (DOWN-AUTONOMY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-06-01
End date: 2026-06-30
Duration (months): 49.0
Total project cost (EUR): 11359709.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

All people with Down Syndrome (DS) suffer from a certain level of impaired learning and memory (cognitive disorders) from childhood onwards, greatly impacting their autonomy and societal integration. This is becoming an increasingly urgent issue as people with DS are more often outliving their care takers, yet an adequate treatment has not yet been developed. Studies have revealed that the cognitive decline in people with DS is associated with overexpression of the DYRK1A protein kinase in the brain. Perha Pharmaceuticals has developed a novel therapeutic compound, Leucettinib-21 (LCTB-21), which acts as a DYRK1A inhibitor that can reduce cognitive decline in children with DS. Ultimately, this will increase the autonomy of people with DS resulting in better societal integration. Perha Pharmaceuticals aims to outlicense LCTB-21 to a large pharmaceutical partner (e.g. Otsuka Pharmaceuticals, Intra-Cellular Therapies) following a successful phase 2a clinical trial.

Keywords: down syndrome,alzheimer s disease,dyrk1a inhibitor,kinase inhibitor
Production of a new biodegradable bioplastic made up of biomolecules extracted from expired milk (SP-Milk)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Italy
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2022-11-30
Duration (months): 6.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The global plastic production reached up to 448 million tons in 2018, of which approximately 8 million tons are entering into the oceans every year. The imprudent use of plastics in our everyday life elevated plastics into the major pollutant component of the world seas and oceans. At the same time, every year in Europe 3-6 million tons of milk are thrown away as waste. Splastica is an innovative startup and a spin off from University of Rome Tor Vergata founded in 2019, whose CEO is a woman, which found an innovative way to turn expired milk into a biobased and biodegradable plastic, by means of a patented process. This bioplastic has been widely characterized, showing good hardness, resistance and great stability in a wide range of temperatures, and in contact with food, water, detergents. The single-use plastic industry is the target field of application of SP-Milk bioplastic. Single-use plastics, often also referred to as disposable plastics, are commonly used for plastic packaging and include items intended to be used only once. The recent EU Directive 2019/904, the SUP Directive, imposes, from July 2021, EU wide market restriction measures (bans) for various single-use products such as plastic cutlery, plates, stirrers and straws, oxo-degradable plastics and expanded polystyrene food and drink containers. SPlastica business idea is to bring to the market SP-Milk bioplastic in the form of granules to be used by plastic processing companies with injection moulding and compression moulding machines or to produce films for industrial packaging applications. Project Objectives within the Women TechEU program are: the optimization of the bioplastic formulation to assess its machinability with industrial machines; the material certifications (bioplastic material; compostability; material in contact with food); the study and design the wastewater treatment system inherent to the SP-Milk production process and the layout of a industrial scale plant.

Keywords: bioplastic biopolymers bio based compostability plastic processing
Modelling food plant trade in the Roman provinces of Gaul and Britannia (FoodMod-RGB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Food is at once a universal necessity and subject to the particularities of environmental and socio-cultural setting. Examining trends in food consumption provides a means with which to detect shifts in past economies, and can greatly augment current understandings of the ways ancient populations interreacted with each other as well as their environments. This project will explore the diverse ways that Roman imperial occupation impacted provincial lifeways, as reflected in foodways, or more specifically, food plants. As food plants were a traded commodity, tracking their trade and transport allows important new light to be shed on economic connectivity, trade networks, as well as culturescapes and the intricate social dynamics that influence consumption patterns. The focus will be on the Roman provinces of Britannia and Gaul, regions which are historically and geographically distinct, but also interconnected in terms of their proximity and necessary transport links. A large body of archaeobotanical data will be collated and entered into a relational database. Data analyses will look to methods from computational archaeology, employing underutilised techniques of advanced network analyses in order to model spatial and social distributions in food plants. In acquiring these new skills, the candidate will be able to combine such methods with existing expertise in large-scale, regional archaeobotanical studies. Results will complement current knowledge on food plant trade by filling the essential gap that is the geographical centre of the European provinces, Gaul, as well as shedding new light on trade in the frontiers. Implications will be far-reaching, offering novel insight into socio-economic networks, as well as human-landscape relationships, and complex nature of cultural dynamics within imperial spheres. Such topics are not only of great relevance to the ancient world, but also to modern studies of food and the impacts of the global economy.

Keywords: archaeobotany,network analysis,roman archaeology
High-Voltage Spinel LNMO Silicon-Graphite Cells and Modules for Automotive and Aeronautic Transport Applications (HighSpin)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Austria,Spain,Germany,Slovenia,France,Italy,Denmark
Call: Advanced high-performance Generation 3b (high capacity / high voltage) Li-ion batteries supporting electro mobility and other applications (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 7999555.53
EU funding (EUR): 7999555.0
Participants: 17
Project status: SIGNED

HighSpin aims to develop high-performing, safe and sustainable generation 3b high-voltage spinel LNMO||Si/C material, cells and modules with a short industrialisation pathway and demonstrate their application for automotive and aeronautic transport applications. The project addresses in full the scope of the HORIZON-CL5-2021-D2-01-02 topic, setting its activities in the “high-voltage” line. The project objectives are: • Further develop the LNMO||Si/C cell chemistry compared to the reference 3beLiEVe baseline, extracting its maximum performance. • Develop and manufacture LNMO||Si/C cells fit for automotive and aeronautic applications. • Design and demonstrate battery modules for automotive and aeronautic applications. • Thoroughly assess the LMNO||Si/C HighSpin technology vs. performance, recyclability, cost and TRL. The HighSpin cell delivers 390 Wh/kg and 925 Wh/l target energy density, 790 W/kg and 1,850 W/l target power density (at 2C), 2,000 deep cycles, and 90 €/kWh target cost (pack-level). The project activities encompass stabilisation of the active materials via microstructure optimisation, the development of high-voltage electrolyte formulations containing LiPF6 and LIFSI, high-speed laser-structuring of the electrodes, and the inclusion of operando sensors in the form of a chip-based Cell Management Unit (CMU). HighSpin will demonstrate TRL 6 at the battery module level, with a module-to-cell gravimetric energy density ratio of 85-to-90% (depending on the application). Recyclability is demonstrated, targeting 90% recycling efficiency at 99.9% purity. HighSpin aims at approaching the market as a second-step generation 3b LNMO||Si/C in the year 2028 (automotive) and 2030 (aeronautics), delivering above 40 GWh/year and 4 billion/year sales volume in the reference year 2030.

Keywords: batteries,electric vehicles,electric aircraft,li ion,lnmo cathode,silicon graphite anode,high voltage electrolyte,battery cell,battery module,sensors,battery recycling,battery testing
Affordable and digital solutions to Build the next generatiON of smart EU buildings (BuildON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Spain,Greece,Italy,Finland,Poland,France,Belgium,United Kingdom
Call: Smarter buildings for better energy performance (HORIZON-CL5-2022-D4-01, 2022)
Start date: 2023-05-01
End date: 2026-10-31
Duration (months): 42.0
Total project cost (EUR): 6737905.0
EU funding (EUR): 5598718.01
Participants: 22
Project status: SIGNED

The 2021 EPBD recast highlights buildings' central role in the energy transition towards an integrated and renewable energy-based EU energy system. Smarter buildings will support the digitalisation and decarbonisation transition to the benefit of building occupants, owners and the energy system. Improving energy performance and reducing energy demands are even more relevant in the context of the REPowerEU Plan to rapidly reduce dependence on Russian fossil fuels and accelerate the green transition. BuildON seeks to develop a highly replicable, generic solution to deliver intelligent building services, facilitate the integration of heterogeneous systems and technologies, and help Build the next generatiON of Smart buildings. The main objective of BuildON is to develop and demonstrate a Smart Transformer Toolbox at TRL8 to plan and achieve improved energy performance applicable to the broadest range of building typologies and smart readiness levels via a comprehensive demonstration campaign involving five representative real-life use cases. This toolbox will offer affordable, adaptative, close-to-market and easy-to-install SRI-aligned services to continuously Monitor, Assess, Predict and Optimise (MAPO services) a building’s performance. A unified representation of the building, exposed through a Universal Building API, will abstract all field-level communication complexity, allowing the energy devices’ homogeneous real-time monitoring and control. Moreover, the generation of (Maturity Level 3 and 4) Digital Twins will allow simulation and control of a building and its systems. User-friendly decision support and user empowerment tools for facility managers and occupants will be part of the toolbox to explore, understand and expand their buildings' smart capabilities. By providing a unified approach to interacting with buildings, the floor is offered to develop a building app store that significantly accelerates the Smart Transformation of existing and new buildings

Keywords: user empowerment,smart readiness indicator,smartness upgrade,iot edge cloud framework,universal building api,ai based mapo services,smart energy management system,digital twins
Autonomous self-adaptive services for TRansformational personalized inclUsivenesS and resilience in mobiliTy (AutoTRUST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Greece,Korea, Republic of,Japan,Portugal,Switzerland,United States,Germany,Italy,Norway,Cyprus,France
Call: User-centric development of vehicle technologies and solutions to optimise the on-board experience and ensure inclusiveness (CCAM Partnership) (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 3999850.0
EU funding (EUR): 3999850.0
Participants: 17
Project status: SIGNED

The AutoTRUST project aims to develop and demonstrate a novel AI-leveraged self-adaptive framework of advanced vehicle technologies and solutions which optimize usability, perception, and experience on-board, and when boarding/off-boarding, in terms of security, privacy, well-being, health and assistance. AutoTRUST provides enhanced inclusiveness and trust in the interaction between users and new automated modes of road transport and mobility services in the transition from human-driven to automated vehicles. Safety and security of vehicle occupants in all circumstances even when the vehicle is driverless by helping to prevent dangerous and inconvenient situations will be of paramount importance. Intense cooperation between users, vehicle manufacturers, suppliers, researchers, and other stakeholders to co-design vehicles with solutions that optimize the on-board experience will be adopted. Moreover, an in-depth knowledge of the benefits of new vehicle technologies and solutions in terms of on-board experience, accessibility, inclusiveness, and trust will be acquired to enable wider user acceptability and contribute to the creation of future standards.

Keywords: inclusive mobility,in cabin monitoring,cooperative situational awareness,user centered design methodology,virtual assistant framework and xai content,hmi interfaces for personalized interactions