Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Un passé qui ne passe pas. The Ethics and Aesthetics of Contemporary French Holocaust Literature (HOLOFRENPOSTMOD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The project addresses the controversial interplay between postmodern narrative strategies and Holocaust representations in recent French fiction. The project’s innovative quality lies in applying Anglo-American theories of postmodernism to French literature, deemed largely immune to the influence of the ‘alien’ and negatively connoted postmodern poetics. The project’s aims are a) to establish the presence of French literary postmodernism, b) to observe parallels between contemporary French- and English-language Holocaust historiographic metafiction, c) to explore the tension between the analysed works’ thematics and aesthetics, and d) to examine the ethical implications of the corpus for French World War II memory. The project is planned for 24 months and is entirely feasible, its successful completion being ensured by suitable project management procedures, the perfect match between the Fellow’s profile and the research, and the ideal working environment offered by the Host. The future Fellow is Dr Helena Duffy, an experienced researcher whose academic work has more than adequately prepared her for the proposed research, and the Host is Royal Holloway (RHUL). By being one of UK’s top research-led universities and home to the Holocaust Research Centre, the leading academic centre of its kind in Europe, RHUL is the best possible context for Dr Duffy’s work. The project will be supervised by Prof. Robert Eaglestone, a world-leading specialist in Holocaust Studies, and carried out in synergy with other eminent scholars. The project, which will result in a range of publications and outreach activities, will create a space for a two-way transfer of knowledge between Dr Duffy, who will contribute her specialism in French literature and postmodernism, and the Host that will offer its expertise in Holocaust Studies. By creating an opportunity to refocus her research, the fellowship will help Dr Duffy attain the position of academic independence and authority she is seeking

Keywords: the holocaust,world war ii,historiographic metafiction,postmodernism,french literature
Microbial communities of Temperate, Artic and Tropical peatlands and their role in the response of carbon storage function to global change (MicroPEAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The present proposal aim at understanding microbial role in peatland sensitivity to climate change at a Global Scale. Peatlands represent one of the most important terrestrial carbon pools, despite they only cover 3% of the earth’s surface they store one third of all terrestrial carbon. This ecosystem has shown to be sensitive to different disturbances in terms of their carbon storage capacity and it is expected a huge CO2 and CH4 release as well as an increase in dissolved organic carbon exportation to freshwater systems, due to climate change. Peatlands cover large extensions in arctic and temperate zones, but they are also present in tropical regions were their ecology and functioning is almost unknown. Due to the valuable peatland role as carbon sink there has been many intents to find out the effect of global change on their functioning, however we are still far to totally comprehend and predict this effect, existing important unsolved questions on the role of microbial decomposer communities (Fungi, Bacteria and Archaea), the structure-function relationship, and so far, none study has assessed the climate change impact at global scale. In order to fill these gaps I propose to survey the microbial communities in Arctic, Temperate and Tropical peatlands and test how differences in origin-legacy can drive peatlands sensitivity to drought events. The proposed methodology is an interdisciplinary approach (combining molecular thechniques, ecosystem measurements and biogeochemistry) with three big components: 1) initial field work study to systematically assess microbial communities from the 3 regions; 2) a microcosm experiment to test the effect of drought (water table reduction) on peatland functioning; 3) a secondment in a drinking water company to put into a management context the results, as these companies are interested in the by-product formation problem thanks to the DOC enhancing in water supplies due to the loss of peatlands storage capacity.

Keywords: peatlands,extracellular enzyme activities,fungi,bacteria,archaea,global change,drought
Coming together or doing it for themselves? The apparent paradox of social information and individuality in foraging (IFSSOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Australia,United Kingdom,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 295940.16
EU funding (EUR): 295940.16
Participants: 3
Project status: CLOSED

Social interactions are fundamental for many ecological and evolutionary processes, including foraging. However, in many animals that use social information, a high degree of individuality in traits such as site and diet selection also exists. This represents an apparent paradox when sociality could potentially reduce individuality. Thus, it is unknown how these two processes interact to shape current and future foraging behaviour. For instance, can some animals become specialised in terms of social information use, or does group foraging erode individuality? This project will determine the interplay between the social and learned components of foraging, and levels of specialisation in habitat use and diet, across of range of seabirds in the Sulidae family (a morphologically constrained but geographically diverse group). State-of-the-art biologgers will be used to collect coupled video and GPS data to quantify the prevalence of group, solitary and commensal foraging in focal taxa representative of tropical and temperate environments, and link strategy to foraging success. State-space models, trained on coupled datasets, will be applied to long-term tracking data from nine Sulid species, to allow a family-scale comparison of specialisation. Through these focused analyses of individual foraging, this research action will enable predictions about the adaptive capabilities of populations to climate change, thus aligning with EU environmental priorities. The current skill set of the experienced researcher, together with a suite of newly acquired skills gained under tutelage of the strong supervisory partnership at host organisations, will make this timely research possible. This global, interdisciplinary project will result in high levels of knowledge exchange, foster international collaboration, and maximise the experienced researcher’s professional development, mobility and career potential, while addressing a fundamental question by combining two fields in bioscience.
Disseminating N-terminomics to Advance Protease Research (ProteaseNter)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-01-01
End date: 2019-06-30
Duration (months): 18.0
Total project cost (EUR): 149900.0
EU funding (EUR): 149900.0
Participants: 1
Project status: CLOSED

Protein N-termini represent a wealth of biological information, such as their generation by limited proteolysis, which sculpts proteome functionality by yielding protein-sized cleavage products with novel functionality. N-terminomics is a branch of functional proteomics and enables the analysis of thousands of protein N-termini in an unbiased manner. By targeting native, proteolytically generated or acetylated protein N-termini as well as uncovering novel translation initiation sites, N-terminomics bears relevance to proteolysis and proteogenomics research. Unlike proteomic assays to study modifications such as phosphorylation, N-terminomics has remained inaccessible to non-expert laboratories due to a lack of ready-to-use kit formats or commercial services. Based on a recently published N-terminomic workflow by my laboratory, the present project aims to fill this niche by laying the foundation to represent N-terminomics (sample preparation up to mass spectrometry analysis) in a kit-like format together with online data analysis. Development steps include inclusion of multiple internal standards for improved sample-to-sample comparability, sole usage of cost-effective, disposable “small-scale” equipment in sample preparation, minimization of required input material, adaption to different input material including cryopreserved and formalin-fixed, paraffin-embedded samples, as well as web-based mass spectrometry data analysis and annotation. This endeavor is based on multiple collaborative projects of the applicant with pharmaceutical companies and backed by interest of proteomic supply companies. In a small forward-looking activity, the project will explore the application N-terminomics in molecular diagnostics of bladder cancer; based on the rationale local infiltration by solid tumors is based on differential proteolysis. This activity serves an initial step to add N-terminomics to the toolbox of molecular pathology.

Keywords: proteolysis,functional proteomics,degradomics
Innovation and Networking for Fatigue and Reliability Analysis of Structures - Training for Assessment of Risk (INFRASTAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Switzerland,Poland,France,France,Denmark,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-05-01
End date: 2020-04-30
Duration (months): 48.0
Total project cost (EUR): 3161112.84
EU funding (EUR): 3161112.84
Participants: 9
Project status: CLOSED

INFRASTAR aims to develop knowledge, expertise and skill for optimal and reliable management of structures. The generic methodology will be applied to bridges and wind turbines in relation to fatigue offering the opportunity to deal with complementary notions (such as old and new asset management, unique and similar structures, wind and traffic actions) while addressing 3 major challenges: 1/advanced modelling of concrete fatigue behaviour, 2/new non destructive testing methods for early aged damage detection and 3/probabilistic approach of structure reliability under fatigue. Benefit of cross-experience and inter-disciplinary synergies will create new knowledge. INFRASTAR proposes innovative solutions for civil infrastructure asset management so that young scientists will acquire a high employment profile in close dialogue between industry and academic partners. Modern engineering methods, including probabilistic approaches, risk and reliability assessment tools, will take into account the effective structural behaviour of existing bridges and wind turbines by exploiting monitored data. Existing methods and current state-of -the art is based on excessive conservatism which produces high costs and hinders sustainability. INFRASTAR will improve knowledge for optimising the design of new structures, for more realistic verification of structural safety and more accurate prediction of future lifetime of the existing structures. That is a challenge for a sustainable development because it reduces building material and energy consumption as well as CO2 production. Within the global framework of optimal infrastructure asset management, INFRASTAR will result in a multi-disciplinary body of knowledge covering generic problems from the design stage process of the new civil infrastructures up to recycling after dismantlement. This approach and the proposed methods and tools are new and will allow a step forward for innovative and effective process.

Keywords: auscultation and monitoring,structural behavior,reliability analysis,fatigue,bridge,wind turbine,tower and foundation,civil infrastructure
Quantum sensors - from the lab to the field (Q-Sense)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Germany,Germany,Italy,Belgium,United States,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 945000.0
EU funding (EUR): 945000.0
Participants: 12
Project status: CLOSED

Q-SENSE will promote international and inter-sector collaboration for the advancement of science and the development of innovation in the area of cold atom quantum sensors. In particular it fosters a shared culture of research and innovation that turns the Nobel-prize winning ideas of cold atom research and precision measurement (Nobel prizes 1997 and 2005) into innovative products. In particular, we bring together a synergetic network of the world leaders in optical clocks and atom interferometers with technology translators and end user applicants to promote space and terrestrial applications of optical clocks and cold atom gravity sensors with an additional eye on implications on policies via the JRC. Our research and innovation programme will deliver knowledge exchange around a technology demonstrator for a space optical clock, development plans for atom interferometer satellite missions, an open source toolbox for simulations of atom interferometer performance in real-world applications and outreach to over 70 companies and the public raising awareness of the potential of optical clocks and cold atom gravimeters for economic and societal benefits, such as in global water monitoring, humanitarian de-mining, satellite navigation and broadband communication. Q-SENSE will enhance the skills of research- and innovation-related human resources in our partner organisations to work seamlessly across sectors and provide new career perspectives in the emerging area of commercial quantum technologies.

Keywords: atomic clock,optical lattice,cold atoms,metrology,precision measurements,interferometry,inertial sensors
Valorisation of splice-switching oligonucleotides for lung cancer therapy (VALSL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-04-01
End date: 2019-09-30
Duration (months): 18.0
Total project cost (EUR): 149894.0
EU funding (EUR): 149894.0
Participants: 1
Project status: CLOSED

Here we propose to test the therapeutic potential of a novel class of reagents, known as splicing-modifying antisense oligonucleotides, in preclinical models of lung adenocarcinoma, including patient-derived tumours in mice. Alternative splicing is a major mechanism of gene regulation by which different messenger RNAs and proteins are generated from a single gene, often displaying distinct, even antagonistic functions. Alterations in alternative splicing have been linked with a plethora of pathologies ranging from neurodegenerative disease to cancer. As a result of detailed mechanistic analyses of alternative splicing regulation in the context of the ERC-funded MASCP project, we have identified antisense oligonucleotides that modulate alternative splicing of a gene that plays key roles in the control of lung cancer cell proliferation. These reagents repress cell growth in vitro as well as inhibit tumour growth when administered intranasally in mouse models of lung adenocarcinoma. The main experimental goal of the ERC PoC proposal is to test the therapeutic value of the antisense oligonucleotides in a variety of patient-derived xenografts in mice, alone or in combination with other treatments, including chemotherapy. This will require previous optimization of dose and delivery route, which is being carried out with available support from other healthcare innovation funds. These goals are aligned with requests from various stakeholders, and funding from the ERC PoC program will be critical for successful valorisation of our assets, intellectual property protection and recruitment of venture capital to establish a spin-off company. Given the high incidence, poor prognosis and lack of efficient therapies for lung cancer, the work proposed can translate fundamental knowledge on molecular mechanisms of gene regulation derived from the ERC-funded MASCP project into applications whose valorisation can bridge the gap to market and provide added value for society.

Keywords: lung cancer,adenocarcinoma,splicing modifying therapy,antisense oligonucleotides
A novel ulcerative colitis treatment - A phase III ready feasibility study (UCRxF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

InDex Pharmaceuticals AB is a pharmaceutical development company based at the Karolinska Institutet Science Park in Stockholm, Sweden. The company´s primary asset is cobitolimod, which is in late phase clinical development as a new medication to treat moderate to severe active ulcerative colitis (UC); a chronic, debilitating disease with a high unmet medical need. UC is caused by chronic inflammation of the colon, and there is no cure. Cobitolimod offers a novel and unique mechanism of action for the treatment of UC, and has demonstrated a higher efficacy and better safety profile in clinical studies than what has been reported for currently approved biological drugs. Cobitolimod is part of the broad InDex portfolio of DNA-based ImmunoModulatory Sequences (referred to as DIMS), which have the potential for treatment of various immunological diseases. Cobitolimod is currently being tested in a phase IIb clinical study with top line results expected in Q4 2018. InDex’s business strategy is to out-license cobitolimod to a larger international pharmaceutical company prior to the initiation of clinical phase III development. This will generate revenues for InDex from upfront and milestone payments as well as royalties from third party sales, which can then be reinvested in the company to finance development of new compounds from the DIMS technology platform. For clinical phase III, additional manufacturing and toxicology work as well as commercial preparations are essential. The planning and preparation of this work is the purpose of this feasibility study, which is a crucial part of the cobitolimod phase III ready programme, increasing the attractiveness of the asset in partnering discussions with pharmaceutical companies looking for innovative new products. A licensing deal will ensure that the development of this promising, innovative drug will continue in a fast and efficient way to reach patients with this debilitating disease.

Keywords: gastroenterology,ulcerative colitis,immunomodulator,toll like receptor 9,toll like receptor 9 agonist,oligonucleotide therapeutics
Real-time Evaluation and Classification of Plastics (RECycle Plastics)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Netherlands
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-12-01
End date: 2020-11-30
Duration (months): 12.0
Total project cost (EUR): 130250.0
EU funding (EUR): 104200.0
Participants: 1
Project status: CLOSED

The Virtual Chemist is a quality analysis machine used within the plastic recycling chain, based on artificial intelligence. This project aims to increase the accuracy of this analysis through the implementation of new, state-of-the-art AI architectures and by using real-time data for further optimization. This proposal calls for a help for a new research associative to help drive this innovation faster and more efficient, thus enabling high accuracy classification algorithms. These algorithms would enable the plastic recycling industry to increase recycling rates while creating a quality recycled material that can be used in new high-grade applications.

Keywords: artificial intelligence,plastic recycling,quality analysis