Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REUNIR - Resilience, Enlargement, Union, Neighbourhood, International Relations Future-proofing EU security, Enlargement and Eastern neighbourhood policies for a new age of international relations (REUNIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Belgium,Norway,Poland,France,Germany,Netherlands,Estonia,Austria,Serbia,Ukraine,Moldova, Republic of,Georgia
Call: Political perspectives for the Eastern Neighbourhood and the Western Balkans (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2999951.25
EU funding (EUR): 2999951.25
Participants: 12
Project status: SIGNED

Russia’s 2022 invasion of Ukraine has ended the post-Cold War European security order, creating new realities in countries neighbouring the EU and shattering illusions in several member states about the Kremlin’s true intentions in wider Europe. By granting candidate status to Ukraine and Moldova and a European perspective to Georgia, the EU has rejected a Russian sphere of influence and instead determined where its future borders should lie. But this decision has not yet led to policies tailored to effectively respond to a geopolitical context which also sees China and other state actors competing for influence. The Eastern Partnership still needs to be fitted with security and connectivity components. In the accession process, existing formats had already reached their limits with, inter alia, the obstructionism by certain member states that is linked to the divisive issue of EU internal reform. This has cost the EU a lot of credibility in the Western Balkans and will take years to resolve. REUNIR, a project with 12 partners from across Europe, examines how the EU can strengthen its foreign and security toolboxes to bolster the resilience and transformation of (potential) candidate countries in a new age of international relations. REUNIR’s foresight approach takes the fundamental uncertainty and openness of alternative futures seriously. Adding the effects of ‘protean power’ unleashed in unforeseen circumstances to a multi-disciplinary approach to the research of the EU’s ‘control power’ in relations with strategic rivals, REUNIR empirically assesses foreign threats to the military, socio-economic and democratic resilience of 9 neighbouring countries, determines capability shortfalls, maps local perceptions of the EU’s support and political perspectives inside the EU on neighbourhood relations. Outlining scenarios up to 2035, REUNIR offers evidence-based policy recommendations to mitigate malign foreign interference and strengthen the EU’s external action.

Keywords: eu foreign and security policy eastern neighbourhood western balkans russia china foresight
SOuthern aFrica research cApacity netwoRk (SOFAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Zimbabwe,Mozambique,Zambia,United Kingdom,Germany
Call: Global Health EDCTP3 Training Networks - Clinical Research Fellowships (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-10-01
End date: 2029-03-31
Duration (months): 54.0
Total project cost (EUR): 4370387.88
EU funding (EUR): 4370387.5
Participants: 6
Project status: SIGNED

The SOuthern aFrica Research cApacity netwoRk (SOFAR) will train a generation of innovative world class and resilient African scientists, clinicians and public health professionals facilitated by a partnership of two higher education institutions (HEIs) in Europe and three African Partner Research Institutions (APRIs) with proven track records of research excellence. SOFAR will train 4 MSc, 6 PhD fellows in high quality and relevant infectious disease research combining taught content with practical experience, and support 5 post-doctoral researchers in conducting high quality infectious disease research on a pathway to establish themselves as independent researchers thus contributing to the generation of a critical mass of research capacity. Training will be delivered through fostering a mutually beneficial network that includes the SOFAR partners ministries of health and policy making organisations, with network meetings, pairing of fellows across institutions and placements of fellows within Africa CDC and WHO. This will facilitate direct transferability of relevant research to practice and policy. SOFAR will develop and deliver a modular digital and face to face training programme (Digital Global Health Academy) aimed at equipping fellows to maximize their research impact. This open access platform will foster a culture of open science, innovation, and knowledge circulation. SOFAR will strengthen processes and systems for recruitment ensuring both transparency and equity through the development of written guidance documents, training and intentional recruitment and review panels; in addition a tailored participatory programme to train academic supervisors at APRIs will be delivered. This will ensure that SOFAR not only trains skilled and internationally competitive researchers, but strengthens the systems and the environment of institutions, ensuring both impact and sustainability and contributing to reversing the brain drain.

Keywords: research capacity building,fellowships,phd,postdocs
Phylogenomic-driven Drug Discovery from Rhodococcus and Saccharomonospora using 2D and 3D Cell Cultures (PhyloDRS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

The project titled, 'Phylogenomic-driven Drug Discovery from Rhodococcus and Saccharomonospora using 2D and 3D Cell Cultures' aims to explore the microbial diversity and genomic landscape of two important, yet somewhat neglected, natural product producing actinobacterial genera, Rhodococcus and Saccharomonospora. Symbiotic systems and unique habitats will serve as isolation sources of novel species, and I will employ state-of-the-art sequencing techniques to perform a comprehensive in depth phylogenomic analysis to fully depict their biocatalytic repertoire and by doing so, unravel their unique natural product potential. I will spearhead the establishment of novel 2D and 3D cultivation techniques with ecomimetic properties to mimic natural scenarios and thereby trigger the production of cryptic metabolites. I will employ sophisticated dereplication and chemical analytical strategies to characterize and structurally elucidate novel chemical entities with drug-like scaffolds. Based on these results, I will be able to test all of the identified natural products for their pharmacological properties within the framework of the Helmholtz drug discovery pipeline and collaboration partners. My targeted and interdisciplinary research approach will allow me to gain valuable genomic and evolutionary insights and streamline the discovery of pharmaceutically valuable natural product scaffolds.

Keywords: natural product discovery secondary metabolites antimicrobial activity
Personalized Text Enhancement for Researchers (PeTER)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Iceland
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-02-29
Duration (months): 8.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Every year, more than 9 million articles are submitted for publication by almost 25 million academics around the world. Scientific publishing is increasingly shaped by an emphasis on speed, particularly in high-stake areas such as medicine and sustainable energy. The advent of scientific preprints has greatly improved our ability to access scientific publications in a timely fashion, but the burden of actually writing those publications still rests solely on the shoulders of overworked researchers. Scientific writing is a challenging, laborious, time-consuming task, and one that most researchers feel they are failing at: according to a recent survey we carried, 79% of our almost 400 respondents stated they have trouble completing more than half of their papers. For over 56% of them, the frustration behind not publishing fast enough is among the top three problems they feel the worst about in their lives as academics. For over 23 % of them, this is the very first source of anxiety. The more time a researcher spends painstakingly choosing words and rearranging paragraphs, the less time they have to collect data, analyze it, formulate theories and actually engage with the public. SageWrite wants to invest in research by giving researchers more time to focus on what really matters: the contents of their articles. SageWrite offers a cutting-edge AI-powered text-enhancement algorithm that is specifically catered for scientific/technical text. Users input a very schematic draft of what they want to write, and our software generates the corresponding perfect text for them. SageWrite helps researchers write better papers, faster. We already have a working prototype that can generate grammatical text starting from a draft. We ask for WomenTech EU's help to add personalization to our platform: we want to research and develop ways to personalize the generated text output based on the user's preferred style and field(s) of expertise.

Keywords: artificial intelligence,natural language generation,academic text
Depolymerizable bio-based multifunctional closed loop recyclable epoxy systems for energy efficient structures (REPOXYBLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,United Kingdom,Switzerland,Greece,Slovenia,Italy,Austria,Portugal
Call: Advanced lightweight materials for energy efficient structures (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 3810103.0
EU funding (EUR): 3810103.0
Participants: 17
Project status: SIGNED

Materials, especially advanced materials, are the backbone and source of prosperity of an industrial society” (Materials 2030 Manifesto). The Green Deal and the Digital Decade establish high-priority policies for Europe, where 70% of all technical innovations are directly or indirectly attributed to advanced materials. Lightweight and high-strength materials have consistently played a key role in the construction of fuel-efficient and high-performing transportation structures. Lightweight materials such as glass and carbon fibres composites are commonly used due to their intrinsic properties such as high mechanical performance. However, the poor recyclability and recovery aspect poses a significant challenge. The end-of-life aspect of these materials is crucial, as when landfilled they release toxic substances into the environment. Moreover, minimising resource use, energy of manufacturing processes and optimising waste disposal of future advanced materials can help mitigate cost and product’s end-to-end footprint across its global lifecycle, thereby significantly improving its overall environmental performance. REPOXYBLE will create a new class of high-performance materials -bio-based epoxy composites- targeting cost and energy effectiveness, recyclability and sustainability. REPOXYBLE assumes an upstream approach more efficient and effective than having to address deficiencies at the end of the product development process. This approach integrates product performance, multifunctionality, sustainability, safety and potential legal concerns, while there is still time to act, on the monomers’ synthesis, the resin formulation and the future composite design. REPOXYBLE is driven by two complementary market applications in the aerospace and automotive sectors.

Keywords: high performance materials bio based epoxy composites energy effectiveness manufacturing,recyclability,sustainability,multifunction perfomance
Importance of human β and Endothelial cell Cooperation for the maturation, organisation and functionality of islet organoids. (BECoop)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

To cure diabetes, functional ß cell mass must be restored. Transplantation of human islets has seen significant progress over the past decades. However, organ donor shortage is a major obstacle. For transplanted patients, poor graft revascularisation and a recurrent autoimmune attack ultimately result in the loss of the graft. Human induced pluripotent stem cell (iPSC)-derived ß cells are a promising alternative source of cells that is inexhaustible and allows genetic interventions prior to transplantation to stimulate revascularisation, immunoprotection and ultimately graft survival. iPSC-ß cells retain an immature phenotype in vitro and only in vivo acquire mature function equivalent to that of native human islets. Intra-islet endothelial cells (ECs) form a necessary niche for pancreatic endocrinogenesis and adult ß-cell function, and they improve islet survival after transplantation. This proposal aims to test the hypothesis that ECs are crucial to generate mature and functional human iPSC-derived islet organoids in vitro and to promote revascularisation, function, adaptation to metabolic challenges and survival in vivo. To this end, we will generate 'vascularised' islet organoids containing iPSC-derived endocrine and ECs. By combining genetic interventions and cutting-edge technologies, such as whole tissue three-dimensional analysis and transcriptomics, we will characterise the impact of ECs on islet organoids. This project will broaden the knowledge on the essential relationship linking structure to function in human islet organoids, paving the way for new human cell therapies.

Keywords: beta cell,endothelial cell,human induced pluripotent stem cell,three dimensional analysis,transcriptomics,adaptation to pregnancy
Intangible Cultural Heritage, Bridging the Past, Present, and Future (INT-ACT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Finland,Portugal,Greece,Romania,United Kingdom
Call: Cultural heritage in transformation – facing change with confidence (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1985532.52
EU funding (EUR): 1985532.5
Participants: 7
Project status: SIGNED

INT-ACT focuses on intangible cultural heritage – i.e., practices and aspects of culture that shape our understanding of ourselves, our sense of belonging, and our relationships to each other and to the tangible cultural environment – as a means of bridging the past, present and future to provide novel approaches to transforming society and addressing societal challenges facing humanity at these times of epochal changes. INT-ACT does this by: 1) developing effective methods for extracting, structuring, and presenting the Emotional, Experiential and Environmental (3E) dimensions as formalised knowledge, 2) developing transdisciplinary methods of inquiry for capturing, compiling, and preserving the 3E dimensions contained in human narratives, 3) proposing and testing interaction techniques, narrative methods and audio-visual media choices for immersive eXtended Reality (XR) environments that present the 3E dimensions of intangible cultural heritage in the context of their associated tangible cultural heritage sites, and 4) providing solutions that address societal challenges by utilising these immersive XR environments. INT-ACT uses four selected tangible cultural heritage sites to develop its methods of extracting their associated intangible cultural heritage knowledge and human narratives, which are used for creating the content of four small-scale XR-based demonstrators. These demonstrators are then used in four case studies dealing with cultural, social and technological changes facing citizens and cultural heritage, namely: cultural tourism, ageing societies, disappearing communities, and immigration and multiculturalism. Each of these case studies targets a different societal challenge of importance and relevance to the multidisciplinary consortium of INT-ACT.

Keywords: intangible cultural heritage,tangible cultural heritage,societal challenges,immersive xr environments,human narratives,formalized knowledge,future societies,ageing,migration,cultural tourism
SCIENTIFIC PHILOSOPHY: RISE AND FALL OF A EUROPEAN IDEAL (1850s-1940s) (SCI-PHIL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Austria,Canada
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-07-15
End date: 2028-07-14
Duration (months): 36.0
Total project cost (EUR): 256442.88
EU funding (EUR): 256442.88
Participants: 4
Project status: CLOSED

SCI-PHIL provides an in-depth historical and theoretical account of the rise and fall of the ideal of ‘scientific philosophy’ (SP) in Europe from the mid 19th century, when the notion emerged, to the 1930s, with the first international congresses on SP, and WW II, which put an end to the project. It focuses primarily on five geographical areas: France, Germany, Austria-Hungary, England and Italy, with a foray into the Russian context.It is original in two senses: (1) It accounts for a neglected chapter in the history of European philosophy in all its transnational and transcultural scope, as part of a multi-faceted process of articulation of a European intellectual space at times characterized by the conflicting pulls of political nationalism and scientific internationalization and tragically punctuated by two world wars; (2) It focuses on a decisive historical moment wherein the problem of relations between philosophy and the sciences emerged in its current configuration and constituted a burning issue that concerned the very scope and vocation of philosophy itself. Indeed, from the 1930s onwards, with Nazi-fascism and WWII, a sharp fracture between philosophy and science occurred, worsened by the Cold War years. Today, in our age of specialist fragmentation, the stakes in bridging this rift have never been higher. Can philosophy contribute to mending the fragmentation of knowledge or is it destined to merely be one discipline amongst others? More than a century ago, scientific philosophers were asking exactly this kind of question. In fact, SP is not merely an antiquated locution to indicate what we now mean by ‘epistemology’ or ‘philosophy of science’, which are specialized fields in the current academic division of labour. On the contrary, it denoted the high hopes of thinkers who, overcoming the two cultures divide, intended to take seriously the revolutionary scientific breakthroughs and set up a new beginning for philosophy, reshaping its scope and methods.

Keywords: scientific philosophy,neo kantianism,french epistemology,phenomenology,logical positivism,twentieth century european philosophy
CLinical impact through AI-assisted MS care (CLAIMS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Spain,Germany,France,Czechia,Belgium,Switzerland,United States,Italy,Finland
Call: An innovative decision-support system for improved care pathways for patients with neurodegenerative diseases and comorbidities (HORIZON-JU-IHI-2022-01-single-stage, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 9633843.75
EU funding (EUR): 4783843.75
Participants: 16
Project status: SIGNED

Multiple sclerosis (MS) is a devastating immune-mediated disorder of the central nervous system. Since there is no cure available yet for MS, the primary therapeutic goal for MS patients is to slow down disability progression and to reduce relapses at early stages of the disease. Despite 19 available disease modifying treatments (DMTs), the large heterogeneity of the disease, further complicated by the high prevalance of comorbidities and multipharmacy, and the limited understanding of the working mechanisms DMT thereon results in a poor and variable treatment response in a real-world setting. The CLAIMS project is a public-private partnership aiming to address this and make precision medicine for MS patients a reality through data-driven prognosis and treatment advice, in order to better slow down disease progression and eventually conversion to progressive MS. We will develop, validate and submit for regulatory approval a companion diagnostic platform, which offers the MS care team a holistic view of the patient through the visualization of the clinical and subclinical biomarkers and the prediction of the expected disease trajectory under different treatments. For biomarker extraction and treatment prediction, state-of-the-art technologies that allow a reliable and scalable implementation across the world will be used. We believe this platform will initiate the paradigm shift from a trial-and-error, experienced-based treatment of MS patients to a first-time-right, value-based holistic treatment management, and will, hence, improve patient outcomes at a lower total cost of care, enhance patient experience and improve the well-being of the care team.

Keywords: multiple sclerosis,companion diagnostics,relapse,comorbidities,ai,dmt,efficacy,treatment,deep learning,bayesian,digital health