Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Designing and Thin Film Engineering of Organic Plastic Ionic Ferroelectrics towards Multi-sensor Electronic Skin (FERROPLAST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-02
End date: 2025-08-01
Duration (months): 27.0
Total project cost (EUR): 213643.36
EU funding (EUR): 213643.36
Participants: 2
Project status: SIGNED

Organic plastic ferroelectrics with inherent pyroelectric and piezoelectric properties have the potential to outperform traditional ceramic ferroelectrics, particularly in terms of sustainability and large area fabrication as flexible coatings. The latter is highly sought as means to continue the current evolution of humanoid robots by offering touch sensitive electronic skins. FERROPLAST focuses on development of plastic ionic crystals (PICs) as the active sensitive component of such skins. PICs are comprised of globular ions tethered by weak intermolecular forces and demonstrate plastic crystal phase at higher temperatures. The PIC ferroelectrics possess intriguing features as high pyro and piezoelectric coefficients, malleability, and multi-axial polarization suitable to realize multi-sensor property in flexible thin films. FERROPLAST proposes: (1) Rational designing of PICs based on chirality, ionic size and intermolecular interaction strength to have high pyro/piezoelectric coefficients; (2) Fabrication of crystalline and phase pure PIC thin films embedded in elastomer by molecular layer deposition (MLD) for application as flexible electronic skin; (3) Study of crystal phase landscape in thin films under variable temperature and pressure using grazing incidence XRD to estimate multi-sensor ability of PICs; (4) Selection of ions by insight in entropy of phase transitions as calculated by first principle DFT studies. At the core of FERROPLAST is knowledge building and exchange between the experienced researcher’s background in supramolecular chemistry to design and synthesize PIC ferroelectrics and the host’s core focus on MLD thin film engineering and characterization of physical properties in thin film structures, and the secondment on first principle DFT calculation of lattice phonon density of state. FERROPLAST will expand the competence and focus of all parties by mutual aid and competence building to push our respective fields further beyond state of art.

Keywords: organic molecular ferroelectric,pyroelectric,piezoelectric,electronic skin,plastic ionic crystal,molecular layer deposition,grazing incidence xrd,lattice phonon,first principle dft
FlowAssist Pouch will help to improve the skin condition of ostomy pouch users, while introducing novel design features, dramatically improving their lifestyle and management of their condition (FlowAssist Pouch)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 3571287.5
EU funding (EUR): 2499901.0
Participants: 1
Project status: CLOSED

Ostoform has developed and patented a new Class I medical technology – FLOWASSIST – by combing a non-absorbent material with an absorbent material (hydrocolloid). The non-absorbent material comprises a flexible spout, positioned beneath the patient’s stoma and is combined with hydrocolloid adhesive to keep the spout in place. This hybrid design directs stoma output away from the patient’s skin and into the pouch. The spout prevents output from being absorbed so the hydrocolloid material does not break down. This means that the appliance lasts for longer, the skin is protected for longer and the risk of leaks and skin complications is significantly reduced. The Ostoform Seal with FLOWASSIST has been successfully developed and commercialised through the H2020 SME Instrument. Ostoform now plans to develop the Ostoform Pouch with the same FLOWASSIST technology. As the ostomy pouch market is larger than the seal market, the novel pouch will increase market opportunity and company value.

Keywords: ostomy patients,stoma care,ostomy pouch,hydrocolloid
The next generation of sensors and imagers enabled by 2D materials digital integration (Next-2Digits)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Sweden,France,Germany,Finland,Czechia,United Kingdom,Netherlands
Call: New generation of advanced electronic and photonic 2D materials-based devices, systems and sensors (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-02, 2022)
Start date: 2023-10-01
End date: 2026-12-31
Duration (months): 39.0
Total project cost (EUR): 5134570.5
EU funding (EUR): 5134570.5
Participants: 12
Project status: SIGNED

Graphene and 2D materials (2DM) have proven superior optoelectronic properties and performance in a plethora of applications with respect to conventional materials. Despite that, specific integration and processing challenges are impeding the industrial uptake of 2DM. In particular, the wafer-scale integration of high-quality and defect free 2DM layers, without disrupting the process-line Si foundries, has not been demonstrated. Next-2Digits will introduce the direct wafer-scale integration of 2DM in PICs using two additive technologies: i) semi dry transfer of Graphene layers for full wafer scale integration and direct die processing and ii) Laser Digital Transfer of pristine 2DM pixels directly on the stack without the need for post-processing. This will enable defect-free interfaces offering high carrier mobility and large bandwidth, paving the way for the next generation of on-chip Photodetectors (PDs) and Modulators which will be validated at TRL5 in three use cases: 1. A miniaturized LiDAR with integrated graphene PD offering high resolution (<0.1mm) and high speed in compact form factor validated in an UAV mapping system. 2. A PIC gas sensor with sensitivity down to 50ppm and miniaturized footprint offering multi-sensing capability validated in a biogas plant leakage sensing system. 3. An on-chip PD receiver offering extended bandwidth (>100nm), high resolution and responsivity >0.5A/W validated in a biomedical OCT imaging system. The project will foster the incorporation of 2DM in PICs and MEMS foundries, enabling future industrial uptake and significantly shorter time-to-market for 2DM-based devices. Companies will be able to offer PIC-based components with (up to 6x times) lower power consumption, lower size (in orders of magnitude) and more than 50% reduced cost. Widespread adoption of such devices will lead to almost €25M of yearly revenues associated with at least 80 new jobs by 2030 for the partners, as well as environmental and social impacts.

Keywords: 2d materials,pics,graphene,digital processing,additive manufacturing,lidars,gas sensors,polarization diverse receiver
International Law and Place (PLACE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 185843.28
EU funding (EUR): 185843.28
Participants: 1
Project status: SIGNED

International law is increasingly being called upon in response to climate change and environmental harm. International courts and tribunals have been asked by States to clarify State obligations in respect to climate change through advisory proceedings, and human rights treaty bodies and courts are seeing a dramatic proliferation of climate-related litigation and complaints. But how is the discipline of international law equipped to rise to the challenge of our current environmental crisis? This project suggests that an important answer lies in the concept of territory, and the matter of place, under international law. Whilst territory is a foundational concept under international law, it offers a rather sterile understanding of the diverse ways through which we relate to the environment around us. It is a legal abstraction which allows international law to carve up the world into neatly organised unites, and does not account for many of the interdependent relations that communities have to each other and non-human actors in place. This project hence proposes that international lawyers would benefit from the development of place as a conceptual frame in international law, operationalised alongside that of territory. It will trace how international law is engaging with a range of notions of place beyond what arguably is possible within the international law of territory, and how it might be shaping the discipline in unacknowledged ways. The importance of the project lies in its ability to theorise and articulate place as a conceptual frame in international law, and articulate how it can enable more precise and robust State obligations relating to climate change and environmental harm. It will contribute to the theoretical and doctrinal debates that international courts and tribunals are currently engaging by opening a set of new questions relating to how we understand the environment through and beyond the international law of territory.

Keywords: critical approaches to international law posthumanism and international law third world approaches to international law critical environmental law critical legal geography public international law
Photo-induced Enantiomeric Separation on chip (PiES-on-chip)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Separating the two enantiomeric versions of a chiral molecule is crucial for ensuring the safety of pharmacological drugs and agrochemicals for the human body and the environment. However, the enantiomeric separation process at industrial level through chiral chromatography is costly and slow. As a result, 90% of chiral pharmaceutical drugs and agrochemicals are being sold as racemic mixtures. The PiEs-on-chip project aims at exploiting enantio-selective optical forces produced in silicon-based Photonic Integrated Circuits (PICs) to separate enantiomers. The chiral light-matter interaction, between the light guided throughout the PIC and the enantiomers results in a momentum transfer due to optical forces that move the particles of opposite chirality in opposite directions, leading to their Photo-induced Enantiomeric Separation (PiES). The PIC would be easy to mass-produce at low cost per device, thus, making optical enantiomeric separation more viable at industry level. Guided modes along integrated rectangular waveguides demonstrated inherent transversal and/or longitudinal spin which generates chiral optical forces that could be used for separating chiral particles in the transversal and/or longitudinal direction. Although the use of silicon-based waveguides is promising, they still lack more strength in the optical forces that can exert on smaller particles like molecules, partially due to the simple designs of the tested PICs. This requires new strategies to enhance enantio-selective interactions. The PiES-on-chip novel approach consists in inversely designing the PIC with topology optimization with the objective of maximizing the produced enantio-selective optical forces. Next, we will fabricate the optimized PIC and measure the generated chiral optical forces with Photo-induced Force Microscopy. Finally, we will deliver the chiral particles over the PIC with a microfluidic layer and experimentally verify the laser-driven enantiomeric-separation on chip.

Keywords: chiral optical forces,nanophotonics inverse design,force microscopy,microfluidics,enantiomeric separation
Next generation ketoamide inhibitors of fibroblast activation protein (FAP) to revolutionize radionuclide therapy in cancer. (KetoFAPIs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

Fibroblast activation protein (FAP) is a serine protease that is highly expressed on cancer-associated-fibroblasts (CAFs), in nearly all tumor types. Its limited presence in healthy tissues makes it an attractive diagnostic and therapeutic biomarker for cancer. UAMC1110, a potent and specific FAP inhibitor discovered by the host, opened the way for the development of the so-called ‘FAPIs’. These are tumor-targeting molecules composed of a UAMC1110 moiety and a radionuclide. The latter can either be a diagnostic radionuclide for PET imaging, or a more cytotoxic radionuclide for cancer therapy. Radiodiagnostic FAPIs are now entering clinical practice, but their therapeutic counterparts face challenges, related to the relatively short tumor residence time of currently available molecules. The latter leads to significant ‘leaking’ of toxic radioactivity from the tumor. To overcome this issue, we will develop ‘ketoFAPIs’ that form long-lived covalent bonds with FAP. This should already ensure significantly longer tumor residence. The ketoFAPIs will also be bound to the surface of gold nanoparticles (AuNPs). The resulting constructs could have further increased tumor residence through the ‘multivalency’ effect. This interdisciplinary proposal covers 1) the chemical preparation of novel ketoFAPIs and derived AuNPs, 2) their in vitro characterization and 3) in vivo investigation in a mouse model of colorectal cancer. Overall, the project can lead to safer and more efficient FAPIs for radiotherapy applications. The status of FAP as a ‘pan-cancer’ biomarker entails that these FAPIs could be applied in nearly all cancer types.

Keywords: fap,ketoamide,cancer,aunps,theranostics,radionuclide therapy
Eco-Friendly Hydrometallurgy for Rare Earths Recycling (FREECOVER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Serbia,Spain,Slovenia,Ireland,Bosnia and Herzegovina,Cuba
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 836542.86
EU funding (EUR): 777400.0
Participants: 10
Project status: SIGNED

Rare Earths Elements (REEs) are crucial for the EU's strategic sectors, in particular renewable energy and electric mobility. However, they are classified Critical Raw Materials (CRMs) with a high supply risk. FREECOVER aims to develop a sustainable hydrometallurgical process for recycling REEs from metallic waste based on eco-friendly materials as key-elements of the separation processes. The project objective is strengthening the supply chain, protect environment and generate new value through its circular economy approach. FREECOVER aims to show the effectiveness of materials derived from natural resources in developing a sustainable REEs recovery process. The demonstration will focus on the recycling of REEs from permanent magnets, which constitute one of the large scale applications of REEs. The proposed process starts from treating the waste magnet by using natural acids, then REEs are separated from the resulting complex liquid phase by liquid/liquid extraction using novel eco-friendly ionic liquids supported on polymeric membranes, based on natural polymers and composites. Then, residual metals will be removed using natural, low-cost, minerals as adsorbents. The resulting aqueous phase will be recycled within the process to obtain a closed water cycle. Finally, the project will show how the metal-loaded adsorbent will be valorized as catalyst in wastewater treatment processes. The project brings together 6 academic partners and 3 companies from EU/AC and one AP from Cuba. The staff involved will perform international, inter-sectoral and interdisciplinary secondments to develop high quality R&I activity, transfer knowledge and benefit of new skills and experience. A detained dissemination and communication activity will be directed to maximize the impact of the project. The EU will benefit from FREECOVER by acquiring a technologies capable to ensure the supply of REEs, and thus increase the competitiveness in green technologies.

Keywords: rare earths elements,critical raw materials,supported ionic liquid membranes,zeolites,x ray absorption spectroscopy,thermodynamics,adsorption,speciation
Spatiotemporal Analytical Modelling for Paleobiology (STAMP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1498735.0
EU funding (EUR): 1498735.0
Participants: 1
Project status: SIGNED

Radical changes in the Earth’s biome as a consequence of climate change will fundamentally affect human society and its relation to the natural world. How can we best model species dynamics, to make predictions for the future? What are the main drivers underlying these dynamics, and how are these changing as we enter the Anthropocene? A great compass for biotic changes we will see in coming decades is the study of changes the Earth has experienced before – from alterations in the distribution of terrestrial and marine mammals, to the dynamic changes in the range and connectivity of forests. There is now a wealth of historic and prehistoric records documenting these processes, including pollen and fossil records, ancient genomes and sedimentary DNA. Here, I propose a research programme called Spatiotemporal Analytical Modelling for Paleobiology (STAMP) to link these disparate types of paleobiological records with the methodological tools of spatiotemporal process analysis. I will focus on three empirical research areas: 1) reconstruction of megafauna species ranges across the late Pleistocene and Holocene; 2) reconstruction of boreal paleo-forest dynamics; 3) study of the historical resilience and mobility of arctic marine mammals. These empirical projects will be supported by two computational approaches to inference: one based on descriptive spatiotemporal modelling, and another based on dynamic simulation-based inference. STAMP will produce a new conceptual paradigm for thinking about paleobiological data and create a statistical methodology that will be widely applicable to palaeontologists, geneticists, paleo-botanists and ecologists worldwide. Ultimately, it will empower the next generation of paleo-scientists with powerful tools to use the living past as a spatial roadmap into the future.

Keywords: sedimentary dna,ancient dna,population genetics,spatiotemporal analysis,paleoecology,dynamic inference
Novel peptidomimetics for inhibition of MDM2 in glioblastoma (GlioLight)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Croatia
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-09-01
End date: 2029-04-30
Duration (months): 44.0
Total project cost (EUR): 187631.76
EU funding (EUR): 187631.76
Participants: 1
Project status: SIGNED

Mouse double minute 2 homolog (MDM2) is a primary antagonist of p53 tumour suppressor, and MDM2 inhibition represents an attractive way to restore p53 function. Peptidomimetics which are based on p53 sequence-derived structure, are one of the most promising tools for mimicking MDM2/p53 interaction. Varying structure of peptidomimetics gives opportunity to measure effect of fine structure changes on inhibition process. Linking peptidomimetics with fluorophores represents an attractive way to spatially track inhibition process. In this project we aim to synthesize novel fluorophore-peptidomimetic probes (FPPs) for MDM2 inhibition. Fluorophores triarylboranes will be covalently linked to peptidomimetics and introduced into patient-derived glioma stem cells. In the first part of the project we will detect effect of MDM2 inhibition on major histocompatibility (MHC-I) peptides presentation at cell surface. Further, we aim to investigate immunogenic response of CD4+ T cells on MHC-I peptides presentation. In the second part of the project we will investigate effect of proteasomal inhibition on MDM2 and p53 degradation, and their role in composition of MHC-I peptides. Immune response on presentation of novel MHC-I repertoire at the cell surface will be tested with co-cultivation with CD4+ T cells. By focusing on these particular pathways, GlioLight intends to hinder the processes that enable GBM cells to grow and escape standard treatments. Ultimately, this effort paves the way for advancements in personalized medicine.

Keywords: mdm2,p53,fluorophores,peptidomimetics,cancer,inhibition,mhc i,mass spectrometry