Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optimising cancer therapy scheduling through personalised mechanistic models and reinforcement learning (B-REDiTx)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Cancers are complex, continuously evolving diseases unique to each individual patient. Yet, most drugs are administered according to fixed, “one-size-fits-all” strategies that always aim to deliver the maximum tolerated dose until it fails due to toxicity or resistance. “Adaptive Cancer Therapy” (AT) is a novel approach which seeks to delay drug resistance by personalising when and how much drug is given, based on the tumour’s response dynamics. After initial success in prostate cancer, there are now important questions about which patients would benefit from AT, and how should we optimally adapt therapy? In this 2-year fellowship, I will develop a computational framework to: i) understand and track resistance evolution from a patient’s tumour burden data (volume, blood biomarkers, ctDNA), and ii) translate this knowledge into personalised dosing strategies to slow resistance evolution and improve quality-of-life. To predict whether a patient will benefit from AT we need a firm, quantitative understanding of the dynamics of resistance evolution. Under supervision of Prof Trevor Graham at the ICR, I will develop a software package (B-REDi) which integrates a family of mathematical models and Bayesian inference to learn about the evolutionary route to resistance in a patient. Subsequently, I will deploy this package to investigate how AT is altering resistance evolution in a clinical trial in ovarian cancer (ACTOv). Finally, I will use deep reinforcement learning to explore how our calibrated models can guide treatment decisions even under uncertainty about resistance mechanisms. In the future, I plan to establish my own lab to develop computational tools to mitigate resistance and toxicity through schedule personalisation. This project will serve me as a steppingstone towards this goal, and it will contribute novel tools and insights towards a future in which mathematical models are used akin to weather forecasts to inform clinical decision-making.

Keywords: cancer drug resistance mathematical modeling ctdna mathematical oncology treatment scheduling
Improving research and innovation to achieve a massive integration of solar renewables (TwInSolar)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: France,Germany,Denmark
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-09-01
End date: 2025-11-30
Duration (months): 39.0
Total project cost (EUR): 1488250.0
EU funding (EUR): 1488249.75
Participants: 5
Project status: SIGNED

The project TwInSolar aims at strengthening the research and innovation capacities of the public laboratory PIMENT of the University of La Reunion (UR), which is located in one of outermost regions of Europe. TwInSolar will create new opportunities inside and outside of Europe and more specifically in the zone surrounding Reunion Island and in insular territories that face similar challenges. This capacity building will be done through the establishment of effective partnerships with the Technical University of Denmark (DTU) and the Fraunhofer Institute for Solar Energy Systems (Fraunhofer), which are internationally renowned research organizations. The dissemination and outreach of TwInSolar will be achieved with the support of the Conference of Peripheral Maritime Regions (CPMR) and the regional R&I agency of Reunion Island (Nexa). Particular emphasis will be placed on issues related to the massive integration of solar energy production in insular territories.

Keywords: solar,renewable,grid integration,smart management,regional outreach,international dissemination,isolated areas
Electronic Mesoscale Modeling of Organic Mixed Conductors (MIXCONDUCTORS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands,Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: CLOSED

The promise of organic materials as biological sensors, electrodes, and memristive devices creates outstanding opportunities for medical diagnosis and treatment, energy storage, as well as neuromorphic computing. At the core of these applications are organic polymers that efficiently support both ionic and electronic transport and therefore are called organic mixed ionic-electronic conductors. These materials’ enabling feature is their ability to convert ionic currents into electronic signals, and vice versa. However, our understanding of these materials is incomplete and the molecular mechanisms underpinning their properties remain elusive. In MIXCONDUCTORS, I will describe and characterize mixed ionic-electronic conductors using machine learning-enhanced multiscale simulations to unravel molecular mechanisms and identify material design guidelines. I propose to use specific machine learning surrogate models to develop a new multiscale method with dramatically increased computational efficiency, unlocking the possibility of bottom-up simulations able to predict device-scale properties. The proposed multiscale method will be used to characterize in silico the growing library of organic mixed conductors, allowing me to uncover their common and/or unique strengths and discover material design guidelines. Finally, together with experimental collaborators, I will be in the position to unravel the molecular mechanisms underpinning some of mixed conductors’ unique properties, enabling me to formulate application-targeted material design guidelines. In summary, MIXCONDUCTORS will provide detailed and unprecedented understanding of the molecular mechanisms behind the functioning of emerging organic mixed ionic-electronic conductors, thereby informing the rational design of improved materials with ramifications for the development of devices that improve health and well-being and enable a future with clean and affordable energy.

Keywords: multiscale modeling,organic mixed ionic electronic conductors,machine learning for soft materials
Unified, AI-enhanced platform for financial advice and financial education (Ningi)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 18.0
Total project cost (EUR): 1165026.0
EU funding (EUR): 1165026.0
Participants: 1
Project status: CLOSED

Ningi Limited (Ningi) was founded in 2021 to address inefficiencies in financial advice technology and the widening advice gap in the UK. Its platform integrates tools into a unified solution that streamlines workflows, reduces errors and lowers costs, enabling advisers to serve more clients and improve outcomes. Early adoption by 45 firms demonstrates demand and validates its approach. The solution also extends access to financial education and guidance for underserved groups, supporting equality, inclusion and financial literacy.

Keywords: financial advice gap,financial education,financial wellbeing
Assuring transparency, efficiency and quality across the supply chain of high- compliance goods. using Blockchain, AI and Digital Twin Technologies (Vigia)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Switzerland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

VIGIA, a recognized leader in cannabis compliance software, is expanding its proven technology into new regulated verticals—phyto-pharma (natural medicines), nutraceuticals, and bio-based products. Building on its success in Europe, Africa, and Asia, and its exclusive partnership with the Swiss Federal Office of Public Health, VIGIA aims to create the digital backbone for transparent, traceable, and compliant bio-based supply chains. Our Objectives: To digitize and automate compliance across regulated industries by delivering a unified SaaS platform that ensures full traceability, quality, and regulatory alignment from cultivation to consumer. The project will extend VIGIA’s validated cannabis compliance system into new markets, supporting the EU’s objectives for safe, sustainable, and ethical bio-economies. How they will be achieved: VIGIA will enhance its platform with AI, blockchain, and digital-twin technologies, integrating data from cultivation, laboratories, and distribution into a secure, ISO-certified environment. The system automatically validates data, detects anomalies, and flags potential non-compliance, while generating standardized, machine-readable reports for EU and national authorities. Real-time dashboards and audit logs improve collaboration between operators and regulators. By transforming manual reporting into automated compliance, VIGIA reduces errors, costs, and administrative burden, ensuring GDPR-compliant data protection and privacy. The project aligns with EU priorities on digitalisation, traceability, and sustainability, directly supporting the European Green Deal and regulatory innovation. With 150+ clients in 20+ countries and strong recurring revenues, VIGIA is ready to scale its impact—positioning Europe as a global leader in trusted, transparent, and compliant bio-based industries.

Keywords: seed to sale traceability automated compliance reporting gdpr compliance end to end monitoring data validation and anomaly detection,quality assurance
EFFICIENT AND SUSTAINABLE COOLING SYSTEM FOR ELECTRONICS IN EVS BASED ON IONIC WIND (EVEHION)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2100000.0
EU funding (EUR): 2100000.0
Participants: 1
Project status: SIGNED

The worldwide need to reduce CO2 emissions is driving the need for society to adopt electric vehicles. But the speed of adoption is being much slower than expected. The biggest problem reported by users for this adoption is the low number of kilometers per charge. At CEDRION we have developed patented technology that allows us to give 7% less consumption to the EV battery. These vehicles are a mobile on wheels due to the amount of electronics they have, sensors, antennas, screens, on-board computers, etc. And like a cell phone, when the temperature rises they are much more inefficient, so they are cooled with fans and heatsinks. Our technology is able to do the same thermal management but with half the weight, volume and consumption, which means that with the adoption of our technology we can improve the performance of the EV by 7%. Our technology is at a proven TRL 7 thanks to the synergist EIC program that has allowed us to reach this status. We can also demonstrate the interest of the market through the innovation contracts we have signed with large companies in the sector such as Mercedes, Valeo or Antolin. Finally, we have a strategic agreement with a Tier 1 and 2 automotive and aeronautics company, FAGOR Electrónica, which allows us to minimize the risk of scaling and manufacturing our cooling systems based on ionic cooling. We are a Spanish start-up with 7 years of life and 20 full time people. With a male/female ratio of 50%, 4 times more than the sector. With a very high technological profile, 19 of the 20 are graduates and there are 7 phd. We are applying for a blended finance project, to enable us to make the leap to TRL 8 in this very competitive sector and then to be able to serve our systems to the whole world. With our systems we will help accelerate the adoption of electric vehicles and save tons of CO2.

Keywords: cooling electronics,electric vehicle,ionic wind,deep tech
Understanding Non-Photochemical Quenching Regulation in a Dynamic Environment. (UNREDE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-15
End date: 2021-01-14
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

Life on Earth relies on photosynthesis that converts water and carbon dioxide into organic molecules using absorbed light by chlorophylls bound to light harvesting complexes (LHC). During evolution, LHC have maximized the capability to capture light energy, allowing organisms to grow even in very low light environments. However, during nutrient deprivation or under high light conditions, when light absorption exceeds the capacity for carbon dioxide fixation, the excess absorbed energy can elicit the generation of reactive oxygen species that cause severe oxidative damage. Photosynthetic organisms have developed mechanisms of non-photochemical quenching (NPQ) that alleviate this photo-oxidative stress in the timescale of seconds to minutes. This NPQ is critical to protect the integrity of the photosynthetic apparatus, allowing the organisms to survive in a dynamic light and nutrient environment. In algae, LHCSR (LHC Stress Related) proteins catalyze NPQ, but their specific role and regulation are poorly understood. For this project, I will use the model organism Chlamydomonas reinhardtii in which two LHCSR proteins have been identified. My main goals will be (1) to characterize components involved in NPQ under conditions experienced in nature, where light intensities vary and nutrient conditions (C, N and S) are suboptimal, and (2) to explore regulatory circuits and signaling molecules that impact NPQ. The experimental approaches involve characterization of novel mutant strains unable to properly trigger NPQ, transcriptomic analysis to elucidate the effect of NPQ deficit on global gene expression and pharmacological approaches to explore the impact of different signaling molecules in NPQ. Understanding NPQ is essential to predict how photosynthetic organisms will behave with changes in atmospheric dioxide fixation levels, temperature and nutrient availability, but will also impact strategies for improving photosynthetic efficiency and tolerance to harsh conditions.

Keywords: photosynthesis,non photochemical quenching,signaling,nutrient deprivation,reactive species,transcriptional regulation,postranslational regulation
INVI self-defense bracelet: feel empowered (INVI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sexual violence remains an important social issue both in developed and developing countries worldwide. Although more and more attention is devoted to this violation of human dignity, and gender equality and women's empowerment are at the top of the agendas of the European Union and United Nations, the number of sexual assault victims is still alarming. Even though the problem is not restricted to a special segment of the society, women represent the majority of victims. We at INVI are convinced that awareness, self-confidence, and education represent the main instruments to tackle this unresolved issue. We aim to deploy in the market the INVI Bracelet: an innovative, patented, non-violent self-defense wearable device, that enables the users to protect themselves and empowers women and men by making them feel safer in their daily lives. The mechanism is simple; in case of emergency, the wearer can activate the safeguard of the bracelet, the capsule breaks and releases an unpleasant and repellent smell which confuses, distracts, and sexually discourages the potential attacker; it can also alarm people in the vicinity since it is perceptible for over 100 meters. Our prototype has been tested and validated with end users in collaboration with the City of Rotterdam and so far 600 bracelets have been sold. Now, we aim to get to an optimized mass manufacturing process, develop a new low-cost version for the developing countries, and reach up to 1 million women by 2020. In addition to protect the potential victims of sexual harassment, we also aim at creating a community of people wearing the Bracelet to speak out against violence, and support gender equality. The performance of this feasibility study will help us minimise the technical, commercial and financial risks before undertaking this ambitious and transcendent project.

Keywords: self defense,self protection wearable device,sexual violence,personal violence,prevention,gender equality,empowerment,human rights
Uncovering the Kinship Matrix: A New Study of Solidarity and Transmission in European Families (KINMATRIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 1487427.0
EU funding (EUR): 1487427.0
Participants: 1
Project status: SIGNED

How do families mobilize to respond to their members’ needs? How do families transmit advantages and disadvantages within and across generations? Most of what we know about these questions is restricted to solidarity and transmission in the nuclear family – a small segment comprising only the closest kin. The project’s core concept – the kinship matrix – offers a much richer view of family members and family ties relevant to solidarity and transmission. It widens the lens to examine nuclear family ties in a larger pattern of relations that constitutes the immediate and extended family network spreading vertically and horizontally. Based on this concept, the project will achieve three objectives: to collect new comparative data on the kinship matrix in five European countries (Objective 1); and to use these data to conduct novel studies of solidarity (Objective 2) and of transmission (Objective 3) that break new ground in family research. The project comprises three subprojects, each dedicated to one objective. Subproject 1 will achieve Objective 1, collecting and preparing data on kinship ties that underpin all analyses on solidarity and transmission. The new comparative survey on the kinship matrix will be supplemented by further sources of population-scale data. Subproject 2 will achieve Objective 2, capturing solidarity in a multigenerational structure of immediate and extended kin. Subproject 3 will achieve Objective 3, capturing status transmission and behavioral transmission across a wide set of relevant kin. All subprojects will study the channels of solidarity and transmission, combining attribute data on status and behavior with relational data on the quality of kinship ties. The project will advance our understanding of the family as a unit of cohesion constitutive to the European social model and as a unit of transmission constitutive to inequality within and across generations. The new data will be released to create a lasting impact on family research.
Molecular characterization of vesicle tethering complexes as novel regulators of collagen trafficking (COTETHERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Collagen maturation (through post-translational modifications, quaternary assembly and transport) is critical for tissues and organ development and homeostasis. This complex process involves numerous actors in different sub-cellular compartments, which in turn depend on highly regulated trafficking systems. Although the mechanisms of vesicular trafficking, membrane tethering and fusion are conserved throughout eukaryotic evolution, highly specialized tethering complexes have evolved to regulate specific fusion events. Recently, a novel pathway regulating collagen trafficking has been identified. Central to this pathway are two trafficking proteins, homologous to, but not part of, classical vesicle tethering components. At present, very little is known about their specific functions. Genetic mutations in both proteins induce rare but highly invalidating and often lethal phenotypes, characterized by abnormal collagen distribution, disorders of the extracellular matrix organization and impairment in endosomal trafficking. In this proposal, I will develop a multidisciplinary approach, merging cutting edge methodologies of affinity purification coupled to mass spectrometry with structural biology and biophysics to decipher the molecular mechanisms driving membrane tethering and, more broadly, endosomal trafficking, through this new complex. These results will unveil unprecedented mechanisms of vesicular trafficking, offering a potential for translational research on collagen-related diseases and also on disorders related to vesicular trafficking, possibly paving the way to future therapeutic strategies.

Keywords: membrane tethering complexes,protein protein interactions,collagen trafficking,molecular recognition,genetic diseases