Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Immune system involvement in sex-specific vulnerability to prenatal stress (ISSVS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-10-21
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Prenatal stress (PS) is more detrimental to males than to females. Evidence is accumulating that PS may play an important etiological role in the incidence of neurodevelopmental disorders, which often show a male bias in incidence. The mechanisms underlying the sex-specific effects of PS are still unknown, but recent evidence implicates a crucial role for microglia, the resident immune cells of the central nervous system. Although in the adult brain microglia are activated only after infection or injury, in the developing neonate microglia show a structurally activated pattern, especially in males, which coincides with the critical period for hormonal action that cause sexual differentiation of the brain. Very recently the immune system, with a central role for microglia cells, was found to play a pivotal role in the masculinizing pathway. I hypothesize that the sex-specific behavioral vulnerability to PS is caused by sex-specific activation of neonatal microglia, leading to deficits in synaptic pruning, through epigenetic alterations in microglia, most notable in the COX2 promoter. COX2 is pivotal in the feed-forward mechanism of microglia activation and implicated in neurodevelopmental disorders. I will induce or block neonatal microglia activation to study whether PGE2 is both necessary and sufficient to induce the sex-specific vulnerability to PS and its mechanisms. These experiments may give important novel insights into the sex-specific sensitivity to the prenatal environment, and help understand the male predominance in many neurodevelopmental disorders. Coming from a world-leading lab with the main focus on sex differences in the brain I will bring important new knowledge and techniques to the host institute, while I will be thoroughly trained in state-of-the-art techniques at the interface of neuroscience and immunology at the country’s best research university, creating a novel niche in the field and preparing me for a professorship position in the EU.

Keywords: sex differences,prenatal stress,microglia,neurodevelopment,pge2,neurodevelopmental disorders,autism,behavior
Carbon Nanotube Quantum Circuits (CNT-QUBIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-04-30
Duration (months): 68.0
Total project cost (EUR): 1998574.0
EU funding (EUR): 1998574.0
Participants: 1
Project status: CLOSED

The aim of this proposal is to use spin qubits defined in carbon nanotube quantum dots to demonstrate measurement-based entanglement in an all-electrical and scalable solid-state architecture. The project makes use of spin-orbit interaction to drive spin rotations in the carbon nanotube host system and hyperfine interaction to store quantum information in the nuclear spin states. The proposal builds on techniques developed by the principal investigator for fast and non-invasive read-out of the electron spin qubits using radio-frequency reflectometry and spin-to-charge conversion. Any quantum computer requires entanglement. One route to achieve entanglement between electron spin qubits in quantum dots is to use the direct interaction of neighbouring qubits due to their electron wavefunction overlap. This approach, however, becomes rapidly impractical for any large scale quantum processor, as distant qubits can only be entangled through the use of qubits in between. Here I propose an alternative strategy which makes use of an intriguing quantum mechanical effect by which two spatially separated spin qubits coupled to a single electrical resonator become entangled if a measurement cannot tell them apart. The quantum information encoded in the entangled electron spin qubits will be transferred to carbon-13 nuclear spins which are used as a quantum memory with coherence times that exceed seconds. Entanglement with further qubits then proceeds again via projective measurements of the electron spin qubits without risk of losing the existing entanglement. When entanglement of the electron spin qubits is heralded – which might take several attempts – the quantum information is transferred again to the nuclear spin states. This allows for the coupling of large numbers of physically separated qubits, building up so-called graph or cluster states in an all-electrical and scalable solid-state architecture.

Keywords: carbon nanotubes,spin qubits,quantum information,quantum dots
SME Innovation Associate: matching MyTherapyTools up with a talented researcher (MyTherapyTools)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2018-03-01
End date: 2019-02-28
Duration (months): 12.0
Total project cost (EUR): 86312.5
EU funding (EUR): 86312.5
Participants: 1
Project status: CLOSED

The H2020 SME Innovation Associate offers the opportunity to MyTherapyTools to recruit a highly qualified specialist that are not available on the Spanish job market, but whose knowledge would be crucial to open up opportunities for innovation and significant growth for the enterprise. The specialised skills / knowledge MTT needs to start realising the opportunity by exploring feasibility and developing concrete innovation projects are: knowledge, ideas and capabilities to program and apply motivational mechanisms of game theory, affective computing, gaming technologies, personal robotics, simulations, game-based learning and training systems. These skills will be applied in: Development of state-of-the-art and marketable products in the field of health using VR/AR, mostly, integrating IA and expert systems technologies for the development of new products. From a business perspective, we are focussed on the healthcare sector, especially in effective rehabilitation, and experience from the candidate in these fields would be positively considered. Our goal is the development of new ICT enabled tools able to contribute significantly to the provisioning of better and more effective rehabilitation. The innovation associate will join MTT to start tasks strategic business plan. One of the activities that will participate will be review MTT's current state and external environment so as to establish the position of the organization with respect to the competition. It will also support the technical team in developing the platform for at home tele-rehabilitation. The contract period is for one year during which the innovation associate will also receive specialized training. The following costs are covered during 12 months: - Salary: 4.000 € / month - Relocation: 2.250 € - Travel and subsistence costs related to the training: 6.000 €

Keywords: cloud based platform,tele rehabilitation treatments
Quantum Environment Engineering for Steered Systems (QUESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 1949570.0
EU funding (EUR): 1949570.0
Participants: 1
Project status: CLOSED

The superconducting quantum computer has very recently reached the theoretical thresholds for fault-tolerant universal quantum computing and a quantum annealer based on superconducting quantum bits, qubits, is already commercially available. However, several fundamental questions on the way to efficient large-scale quantum computing have to be answered: qubit initialization, extreme gate accuracy, and quantum-level power consumption. This project, QUESS, aims for a breakthrough in the realization and control of dissipative environments for quantum devices. Based on novel concepts for normal-metal components integrated with superconducting quantum nanoelectronics, we experimentally realize in-situ-tunable low-temperature environments for superconducting qubits. These environments can be used to precisely reset qubits at will, thus providing an ideal initialization scheme for the quantum computer. The environment can also be well decoupled from the qubit to allow for coherent quantum computing. Utilizing this base technology, we find fundamental quantum-mechanical limitations to the accuracy and power consumption in quantum control, and realize optimal strategies to achieve these limits in practice. Finally, we build a concept of a universal quantum simulator for non-Markovian open quantum systems and experimentally realize its basic building blocks. This proposal provides key missing ingredients in realizing efficient large-scale quantum computers ultimately leading to a quantum technological revolution, with envisioned practical applications in materials and drug design, energy harvesting, artificial intelligence, telecommunications, and internet of things. Furthermore, this project opens fruitful horizons for tunable environments in quantum technology beyond the superconducting quantum computer, for applications of quantum-limited control, for quantum annealing, and for simulators of non-Markovian open quantum systems.

Keywords: quantum electronics,superconducting qubit,single electron tunneling,josephson junction,quantum computer,open quantum system,decoherence,fluctuation relations,non markovian quantum evolution
How a mutualism evolves: learning, coevolution, and their ecosystem consequences in human-honeyguide interactions (Honeyguides-Humans)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: South Africa,United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2024-05-31
Duration (months): 84.0
Total project cost (EUR): 1998885.0
EU funding (EUR): 1408260.0
Participants: 2
Project status: SIGNED

Species interactions such as mutualism, parasitism and predation underpin much of life’s diversity. We aim to understand the mechanistic role of learnt traits in the origin and maintenance of mutualistic interactions between species, and to test their evolutionary and ecological consequences. To do so, we shall study a remarkable mutualism: the foraging partnership between an African bird species, the greater honeyguide Indicator indicator, and the human honey-hunters whom it guides to bees’ nests. Honeyguides know where bees’ nests are located and like to eat beeswax; humans have the ability to subdue the bees and open the nest, thus exposing beeswax for the honeyguides and honey for the humans. This model system gives us a wonderful opportunity to study mutualisms, because local human and honeyguide populations vary strikingly in whether and how they interact, and because we can readily manipulate these interactions experimentally. We have already demonstrated that it is fully feasible to carry out observational and experimental work at a study site we have established in cooperation with a honey-hunting community in northern Mozambique. Here, and at a series of comparative field sites we have identified in south-eastern Africa, we shall ask: is learning involved in maintaining a geographical mosaic of honeyguide adaptation to local human cultures? How does reciprocal communication between humans and honeyguides mediate their interactions? What are the effects of cultural co-extinctions on each partner and their ecosystems, and how quickly can such cultures be re-ignited following their loss? In so doing we shall test for the first time the hypothesis that reciprocal learning can give rise to matching cultural traits between interacting species. Understanding the role of such phenotypic plasticity is crucial to explain how and why the outcome of species interactions varies in space and time, and to predict how they will respond to a rapidly changing world.

Keywords: avian behavioural ecology,human animal ecological interactions,learning and cultural evolution
EUROPEAN DEVELOPMENT OF BIONICS VESTIBULAR IMPLANT FOR BILATERAL VESTIBULAR DYSFUNCTION (BionicVEST)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Australia,Spain,Belgium,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-09-01
End date: 2023-02-28
Duration (months): 54.0
Total project cost (EUR): 2924690.0
EU funding (EUR): 2899690.0
Participants: 7
Project status: SIGNED

Vertigo of vestibular origin has a global prevalence of 38% in the elderly and deserves special attention because of the high risk of falls and permanent functional disability, and even death. This seriously handicaps their lives, disabling them of doing routine daily activities, such as driving and even walking. The associated total costs are around 60.000 million euros in Europe. It is estimated that at least 100 million people worldwide could benefit from a vestibular implant as an effective solution to this disease. Restoring the function of the vestibular labyrinths was not possible until now. Current devices, under research, detect change in angular velocity of the cephalic movements through gyroscopes and use this information to stimulate the semicircular canals. However, they do not code vertical and horizontal accelerations, used to sense gravitational forces, keep a stand up position and restore the sense of self-position. Linear accelerations are detected by a different set of structures which are a more complex and harder to access: the saccule and utricle. This project will develop the first system to electrically reproduce linear accelerations in the otolith organ by stimulating their neural ends. The project will have three phases: Device design, fabrication and clinical trial. Therefore, the objectives will be: 1) to study, for the first time, vestibular pathways through electrical saccule-utricle stimulation; 2) to develop a vestibular response telemetry system to analyse the evoked action potential of vestibular nerve; 3) to design, manufacture and test the first vestibular prosthesis that restores the sense of linear accelerations. The main objectives are to demonstrate the safety of a vestibular implant for human, to determine its efficacy in restoring vestibular function by measuring the improvement in objective and to objectify the improvement in Quality of Life of patients.

Keywords: vestibular implant,active bionic protheses,vestibular dysfunction,utriccle and saccule physiology,elderly,balance coding strategy,neural stimulation
Shore Connection Solution for an efficient, environmentally friendly and safe electric power supply to vessels (eSHORE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Iceland
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nearly 70% of ship emissions are released within 400 km of land, ships are major contributors to air pollution in coastal communities. In harbor cities ship emissions are often a leading source of urban pollution and, in particular, fine particulate matter (PM). When ships are docked, they use their engines and/or generators to power onboard systems and equipments, generating substantial pollution in port areas. In this context, Shore connection technology is emerging as the most cost-effective means of reducing pollution from ships at berth, as it eliminates ships’ need to run their engines by providing electricity directly from the electric grid. In fact, EU recommendation 2006/336/EC highlights shore connection as the optimal solution in terms of both cost savings and pollution control. Traditionally, high cost on integrating and operating shore connection service into the harbour, along with frequent overload incidents, causing personal and material damage, have hampered its wide adoption. eTactica is positioned at this market gap. eTactica is an Iceland based company founded in 2009 with the aim to provide the most accurate control and information over energy consumption. eTactica’s Shore Connection Solution (SCS) is an energy monitoring, control, and communications system that streamlines the connection and invoicing process. The SCS utilizes our patented current meter bar. The versatility of our devices and solution enables its integration within current infrastructure. In this way, harbours see the cost of integrating advance shore connection management reduced up to 75%. The high return of investment and short payback period (less than 2 years) is bound to increase penetration of shore connection technologies. eSHORE contributes to a faster realization of EU objectives through the reduction of emissions from vessels docked at the harbour, resulting in a drastic improvement of the air quality in the surrounding areas of the harbour (typically urban areas).

Keywords: energy management,monitoring,electricity,harbours,vessels,efficiency,reduce pollution
ADVANCED ANTICOUNTERFEITING SCANNABLE CODES 2 ENHANCE TRUST AND ENFORCE TRACEABILITY (SCAN-2-TRUST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

It is a well known fact that in today's complex globalised world, if you can make it, counterfeiters can fake it. Indeed, as per 2016 Frontier EcoIt is a well known fact that in today's complex globalised world, if you can make it, counterfeiters can fake it. Indeed, as per 2016 Frontier Economics report, taken together, the negative impacts of counterfeiting & piracy are projected to drain $4.2-tn (trillions!) from global economy and put 5.4M jobs at risk by 2022. In addition, current solutions are either too easy to imitate to a level that the normal user is deceived, too expensive to be practical to be used in low value products, the process too cumbersome to implement at unit-level, or, usually, a combination of all aforementioned drawbacks, so in practice, no current system provides practical protection against counterfeiters. SCAN-2-TRUST is a game-changing "Internet of Packaging" platform that allows cost-effective unit-level authenticity assessment thanks to our unique, proprietary, copy-proof secure 2D barcode, based on 3-patents. Moreover, our technology also let brands further engage with their clients and provides accurate actionable information on the full product lifecycle: from the very instant the product is packaged at the factory, to the final moment, when package is recycled. The value of our Serviceable Available Market (SAM) is ~$206-bn (Year-1). However, for the first 4-years, we will focus on the markets we have gained early traction: e.g. food & beverages, industrial goods, secure documents/ticketing. SCAN-2-TRUST has been validated by Fortune-500 clients, e.g. SGS, Pernod Ricard, Abbott Labs, Syngenta, Dow Chemicals, ABInBev, Leybold, Nexans, LVMH, Agfa, Nestle (see letters of support in 4.2.B). To-date, we help protect +25M products in +70 countries every year, and have demonstrated global delivery and project rollout capability with key clients (see explanatory videos, awards received & latest news in our webpage: www.scantrust.com).

Keywords: 2d barcode,authentication,supply chain,packaging,counterfeiting,safety,internet of things,recycling,drugs packaging,internet of packaging,consumer engagement,inspection
Engineered microbial factories for CO2 exploitation in an integrated waste treatment platform (ENGICOIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,Austria,Italy,Sweden,Belgium,Netherlands,United Kingdom
Call: Microbial platforms for CO2-reuse processes in the low-carbon economy (H2020-NMBP-BIO-2017, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 6986910.0
EU funding (EUR): 6986910.0
Participants: 14
Project status: CLOSED

The ENGICOIN proposal aims at the development, from TRL3 to TRL5, of three new microbial factories (MFs), integrated in an organic waste anaerobic digestion (AD) platform, based on engineered strains exploiting CO2 sources and renewable solar radiation or H2 for the production of value-added chemicals, namely: MF.1) the cyanobacteria Synechocystis to produce lactic acid from either biogas combustion flue gases (CO2 concentration ~ 15%) or pure and costless CO2 streams from biogas-to-biomethane purification. MF.2) the aerobic and toxic metal tolerant Ralstonia eutropha to produce PHA bioplastics from biogas combustion flue gases and complementary carbon sources derived from the AD digestate. MF.3) the anaerobic Acetobacterium woodii to produce acetone from the CO2 stream from biogas-to-biomethane purification. High process integration will be guaranteed by taking advantage of low-grade heat sources (e.g. from cogenerative biogas-fired engine or an tailored PEM electrolyser), exploitable side gas streams (e.g. O2 from electrolysis, CO2 from biomethane purification), low-price electricity produced during night-time by a biogas-fired-engine cogeneration unit or even intensified operation conditions (e.g. up to 10 bars pressure for the anaerobic acetone production bioreactor; led-integrated photo-bioreactor). This is an essential feature, alongside with the high conversion rates enabled by synthetic and systems biology on the above microorganisms, to achieve competitive selling prices for the key target products (1.45 €/kg for lactic acid; 3.5 €/kg for PHA; 1 €/kg for acetone). Notwithstading the key application platform (anaerobic biorefinery based on organic wastes) the innovative production processes developed have a great exploitation potential in other application contexts: flue gases from different combustion appliances (e.g. cement kilns), alcoholic fermentation CO2 streams (e.g. lignocelluosic biorefineries, breweries), etc.

Keywords: biogas,hydrogen,lactic acid,acetone