Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Self-organising principles underlying nanodomain formation and function (SONA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Signal transduction of diverse inputs often relies on a comparatively small number of central signal integrators. The resulting question, how such a central signal transmission protein can recognise the specific input and trigger the respective, appropriate outputs is as of yet unresolved. However, recent research focusing on plant signal transduction suggested that the precise spatiotemporal organisation and the organisation of signalling modules into membrane nanodomains could play a crucial role in achieving signal specificity. A prime example in Arabidopsis is the GTPase RHO OF PLANTS (ROP)6 that forms nanodomains in the auxin-mediated gravitropic response as well as in osmotic stress. In SONA, I will use ROP6 as model system for membrane organisation at the nanoscale to dissect the self-organising principles of nanodomain formation and function. My host group and collaborators discovered how ROP6 assembles into nanodomains, which will be the foundation for a detailed and innovative characterisation of how protein-lipid interplay contributes to nanodomain specificity. Based on preliminary results, I will use live super-resolution microscopy to investigate how and where ROP6 nanodomains are nucleated after auxin and hyperosmotic treatment, respectively. In addition, I have two parallel, complementing goals in identifying the membrane lipids necessary for sustaining the nanodomains and the protein components required for feedback loops and specificity in ROP6 nanodomain signalling. Taken together, SONA will give insights into the membrane organisation of ROP6 nanodomains at unprecedented spatiotemporal resolution. It will also challenge our understanding of the signal transduction at the plasma membrane by emphasising how self-organising principles contribute to the formation of specific signalling modules. Finally, this action will provide me with valuable training to develop into an independent researcher in the field of plant lipid and membrane research.

Keywords: plant membrane nanodomains,auxin,osmotic stress,receptor kinase,lipid signaling,rho gtpase,arabidopsis,roots,proximity labeling,lipidomics,single molecule super resolution microscopy
Scalable Knowledge Graphs Platform for the New Era of Intelligent Connected Data (QLeverize Platform)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Switzerland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Large enterprises are constrained by traditional data systems that force interconnected information into fragmented tables, hindering real-time insights for critical problems like fraud detection and drug discovery. Existing graph databases fail to scale affordably past billions of relationships, requiring costly, power-hungry infrastructure. The proprietary QLeverize Platform solves this by leveraging the opensource QLever engine to deliver the world's first RDF knowledge graph platform that scales, is designed for deployment in enterprise environments, and AI-driven accessibility for ease of use. QLever is an ultra-fast, highly scalable RDF knowledge graph database, designed for commodity hardware to enable real-time analysis of very large knowledge graphs. For instance, QLever queries over 200 billion OpenStreetMap triples on a €3,000 server (64 GB RAM, 16 cores), delivering simple queries in milliseconds and complex ones in seconds, where other systems often time out. This breakthrough offers up to 10x faster query speed at a 20x lower cost and up to 90% reduction in energy consumption compared to alternative solutions. The platform is at TRL 7 and targets market entry by 2028 through this blended finance project with 3 key objectives to reach TRL 8: 1.Enterprise stack development: implementing full cloud readiness, high-availability features, and GeoSPARQL compliance. 2.Neuro-symbolic AI integration: Developing integrated Generative, Agentic, and Causal AI layers to enable non-experts to query data using natural language, automate workflows, and provide traceability. 3.Validate and qualify the platform at scale: run large-scale pilots in real operating environments. QLeverize will disrupt the market by establishing the knowledge graph QLeverize Platform as the default for enterprise data intelligence, already validated by firms like BMW and UniProt. The solution aligns with the EU Green Deal by promoting exceptional resource efficiency and digital sovereignty.

Keywords: software,computer science,knowledge graphs,enterprise data management,data infrastructure,data management algorithms,high performance computing
NANOTRIBOLOGY: STUDIES OF FRICTION AND OSTEOINTEGRATION AT THE NANOSCALE AND ITS RELATIONSHIP WITH INTERFACES (NANOTRIOSTEO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Brazil,Argentina,Slovenia
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 345000.0
EU funding (EUR): 345000.0
Participants: 4
Project status: SIGNED

NANOTRIOSTEO is a scientific cooperation project based on experimental and theoretical research of the surface iteractions on solid materials at nanoscale for improving materials for engineering applications. NANOTRIOSTEO will provide theoretical support for better understanding of process at the nanotribo interface developing models based on experimental information that provide feed-back to materials design. NANOTRIOSTEO will develop capacities for the study at the level of the Density Functional Theory and Molecular Dynamics of molecular aspects of nanotribology and oesteointegration phenomena in materials used for surgical replacement of hip and knee with an endoprosthesis. Modern materials science and in particular surface science is all about the molecular level knowledge of physical, chemical, and biological processes occurring in the nanometer scale vicinity of surfaces or interfaces. NANOTRIOSTEO will apply computer simulations methods that allow complementing experimental studies and interpreting at atomic scale the lubrication properties of different carbon nanostructures, SiCx/Steel and Ti oxides interfaces. Nanotribology is a key in understanding the first events of friction, wear and adhesion behaviours at solid/solid and solid/liquid interfaces of materials in relative motion. An exceptional expertise in theoretical physics and chemistry and simulations is an added value for understanding process at molecular level. NANOTRIOSTEO activities are linked to research as well as to education. Both of them will empower the cooperation among the partners involved. This project will allow the start of networking among the four participants; this cooperation will be strengthened due to the secondments that will be carried out during NANOTRIOSTEO. Furthermore, this project will be the foundation for future cooperation among the partners due to their interdisciplinary expertise and the synergetic approach to be used within this project.

Keywords: molecular dynamics tribology coatings osteointegration dft biocompatibility surface adsorption
Forward-Models of Cosmic Dawn: connecting 21cm simulations to the real world (FORWARD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

FORWARD will enable a new generation of transformational probes of Cosmic Dawn (CD) to provide meaningful inference on key questions of galaxy formation. The CD contains some of the most sought-after insights into galaxy formation. Though these secrets remain locked away by a host of formidable real-world challenges, upcoming radio telescopes are optimistic. Interferometers such as HERA and future SKA, along with global experiments such as EDGES-3 are honed to observe the faint 21cm emission from neutral Hydrogen, redshifted to 50-150 MHz, in complementary ways. The dominant limitation of current experiments are spectral systematics that couple with overwhelmingly bright foregrounds. As we enter the regime in which the most extreme physical models begin to be ruled out by observations, meaningful inference of key parameters is most susceptible to inaccuracies in accounting for these systematics. Prior efforts to provide parameter constraints from CD have focused on forecasts, and treated systematics crudely and optimistically. FORWARD will synthesise the popular semi-numerical simulation code 21cmFAST and a radically overhauled parameter-inference engine, 21cmMC-2, with a series of new pluggable modules designed to efficiently forward-model the response of realistic interferometers, enabling the most direct comparison of theory to data. By applying this novel machinery jointly to observations from HERA and EDGES-3, we will (i) provide meaningful constraints on the parameters of galaxy formation during CD, (ii) build confidence in the reported detections, and (iii) enable future joint constraints from the SKA & EDGES-3. The framework developed will follow a legacy of code excellence, providing a bedrock for state-of-the-art developments over the coming years.

Keywords: cosmic dawn 21cm cosmology semi numerical models bayesian inference
Linked User-driven Multidisciplinary Exploration Network (LUMEN)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Partnership: EOSC (co-programmed)
Countries involved: France,Poland,Sweden,Germany,Croatia,Italy,Belgium,United Kingdom,Portugal,Austria
Call: Innovative and customizable services for EOSC Exchange (HORIZON-INFRA-2024-EOSC-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 6999997.5
EU funding (EUR): 6999997.5
Participants: 20
Project status: SIGNED

The LUMEN project is a groundbreaking initiative aimed at revolutionizing cross-domain collaboration and discovery processes in the fields of Mathematics (Maths), Social Sciences and Humanities (SSH), Earth System (ES), and Molecular Dynamics (MD), and beyond. Leveraging the successful GoTriple platform, renowned for its service to the SSH community, LUMEN seeks to extend its functionality to foster interoperability across scientific domains. Through interdisciplinary solutions spanning all four domains, LUMEN will redefine the process of discovery with radical innovations, simplifying initial research phases and facilitating access to advanced AI-powered tools for researchers. By expanding existing discovery platforms in the SSH and Maths domains and developing new platforms for other domains, LUMEN aims to fundamentally transform EOSC services, promoting innovative and customizable solutions for data discovery, attracting new users, and fostering Open Science principles. The project will also drive multidisciplinary cooperation through collaborative platforms and onboard new scientific communities into EOSC, providing them with the necessary tools. Ultimately, LUMEN seeks to revolutionize how research outputs are created, shared, and utilized across scientific domains, enhancing scientific discoveries, fostering interdisciplinary collaboration, and promoting innovation and trust in European scientific research.

Keywords: discovery services ai chatbot gotriple eosc
Low-cost and eco-friendly localized water-in-salt electrolyte-based rechargeable anode-free Zn-ion batteries (WIZBAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Aqueous zinc ion batteries (AZIBs) have attracted tremendous attention for the application in the field of large-scale energy storage devices due to their instinct properties of non-flammability, low-cost and high ionic conductivity of aqueous electrolyte. Rechargeable anode-free zinc ion batteries (AFZIBs) have multiple advantages over its conventional counterpart, especially by removing Zn metal in its initial state, the weight and volume of anode-free cells is significantly reduced, maximizing the energy density of AZIBs. The obstacles impeding practical applications of AFZIBs originated from the H2 evolution during batteries cycling. In a typical zinc-ion battery electrolyte, Zn2+ solvated with six water molecules forms hydrated zinc ion [Zn(H2O)6]2+. Preliminary research implies that H2 evolution primarily originates from solvated water, rather than free water not interacting with Zn2+, since the interaction between H2O and Zn2+ weakens the O-H bond of H2O, leading to deprotonation of the solvated water. Water-in-salt electrolytes (WiSEs) can prevent the formation of hydrated zinc ions ([Zn(H2O)6]2+), thus, suppressing H2 evolution. However, in such case, boosted electrochemical performance is achieved only at high costs because a large quantity of expensive fluorinated salts is used in electrolyte. In this project, we aim to lower the WiSE salt concentration by diluting the electrolytes with an inert solvent (called a diluent) that dissolves the water but not the salt. Therefore, the diluent does not alter the salt solvation structure of WiEs, forming a localized water-in-salt electrolyte (LWiSE). The as-designed LWiSE is expected to have the same effect as WiSE regarding H2 evolution suppression but is comparable to the conventional dilute aqueous electrolyte in terms of production cost and eco-friendliness. The as-designed LWiSE will be finally demonstrated in different prototypes, from lab-scale coin cells to industry large-scale pouch cells.

Keywords: zinc ion batteries aqueous electrolyte anode free batteries solvation structure
Antibody-guided design of multivalent nanoparticle vaccines against bacterial pathogens (NANOBAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2485312.0
EU funding (EUR): 2485312.0
Participants: 1
Project status: SIGNED

Vaccines are the most effective single measure to protect populations against infectious diseases without promoting antimicrobial resistance (AMR). In this proposal, I intend to harness the rapid developments in protein design and quantitative and structural mass spectrometry to i) enable detailed molecular characterization of circulating serum antibody repertories, ii) establish a generalizable framework for antibody-guided design of next-generation nanoparticle vaccines against bacteria and iii) use the developed nanoparticle vaccines to investigate structural properties of protective antibody responses required for immunity. The planned work relies on identifying and producing protective antigen-specific monoclonal antibodies from immune individuals. These antibodies are used to structurally characterize conserved epitopes in their correct three-dimensional conformation. The structural information is then harnessed to design multivalent nanoparticle vaccine candidates. The planned work is focused on i) determining the optimal combination of epitopes that generates the highest level of protection using Streptococcus pyogenes as a model system, ii) determine the molecular properties of the circulating serum antibody response that mediates the protection and iii) modify the epitope design to target conserved structural motifs typically found within protein families to produce immunogens that confer cross-pathogen protection. The work will be novel as it will for the first time, demonstrate the design of a protective vaccine candidate against a protein family associated with distinct bacterial pathogens and infections. The concept will be extendable to other protein families and bacterial pathogens to aid in the combat against AMR.

Keywords: structural proteomics,quantiative proteomics,vaccine design,biological mass spectrometry,infectious disease,hydrogen deuterium exchange mass spectrometry,cross linking mass spectrometry
Investigating the biodegradation and fate of plastics in the gut of xylophagous insect larvae (PLASTIGUT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

The recalcitrance of plastics leads to their accumulation in the environment, where physical deterioration in absence of degradation is causing widespread pollution. Microplastics have been found to enter the food chain and to bio accumulate with hitherto unknown long-term health effects, making plastic pollution one of the major environmental problems of our time. In recent years, a plethora of plastic degrading microorganisms and enzymes have been reported, however their degradation efficiencies, especially for conventional plastics, are often underwhelming. Enzymes capable of plastic degradation share a close homology to enzymes involved in the degradation of natural plant derived polymers, such as esterases, cutinases, lipases. It is therefore no surprise that most plastic degrading microorganisms and enzymes are found in the soil environment and compost, where plant litter is a dominant carbon source. Recently, microorganisms inhabiting the guts of xylophagous insect larvae were reported to degrade highly recalcitrant plastics such as polyethylene, polystyrene and polyurethane. However, evidence of this degradation remains scarce and to date few enzymes capable of degrading these polymers could be confirmed. in this regard, xylophagous insect larvae harbour much untapped potential for the discovery of unknown plastic degrading microorganisms and enzymes that could help mitigate plastic pollution. This project will benefit from my previous experience with stable isotope probing, sequencing analysis and plastic degradation by using carbon-13 labelled plastics to investigate plastic fate and degradation in the gut of xylophagous insect larvae. Cryosectioning of the larval gut and state-of-the-art imaging technologies will be used to study plastic fate. Stable isotope probing coupled with metagenomics and proteomics will then identify genes and enzymes responsible for plastic degradation and their function will be confirmed in vitro through heterologous expression.

Keywords: plastic biodegradation,stable isotope probing,metagenomics,metaproteomics,heterologous expression
Molecular mechanisms underlying the evolution of central neural circuits and behaviour (MolEvoNeu)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-01
End date: 2028-04-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

The immense variety of behaviours displayed by animals – including ourselves- arose through the evolution of neural circuits within the brain. However, how central neuronal circuits change over time, integrating these modifications within the brain's highly interconnected networks remains largely unknown. Particularly puzzling is that evolution acts at the level of the genome but behaviour arises through the activity of neuronal networks. How are these two levels integrated? How do evolutionary changes on the genome lead to changes in neuronal circuits that themselves lead to behavioural divergences across animals? The larval olfactory system of Drosophila provides a powerful model to address these questions because: 1) different Drosophila species have evolved diverse odour-guided behaviours, 2) the olfactory system is numerically simple yet parallels more complex circuits, and 3) the availability of molecular tools and resources. I will use this system to identify hotspots of central neuronal circuit evolution at both functional and genetic levels by comparing two Drosophila species. First, leveraging comparative connectomic data from the host lab, I will use calcium imaging and modelling to examine the functional impact of cross-species connectomic changes. Second, I will employ a combination of transcriptomic approaches to determine the molecular changes that lead to functional and connectivity differences. Finally, I will apply these insights to re-engineer the neuronal circuits across species by making use of the genetic tools available in D. melanogaster. This research will enhance our understanding of the intricate interactions between genes, neuronal circuits, and behaviour in the context of evolution.

Keywords: evolution,central neuronal circuits,brain,olfaction,drosophila