Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Real-time Multiscale Imaging of Pathological Calcification - Zooming in on Aortic Valve Calcification (REVALVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Calcifying Aortic Valve Disease (CAVD) is a cellular-driven disease that actively alters the structure and composition of the valve extracellular matrix, leading to severe disfunction of the heart. Because the molecular mechanisms underlying CAVD are still unknown, there are currently no drug-based therapies and valve replacement is the only available treatment. Specifically, it is still unknown (1) how the disease modifies the extracellular matrix (ECM) to become susceptible for mineralization, (2) how cell differentiation and matrix modification lead to calcification, and (3) how the mineral develops within the matrix. We lack these answers mainly due to our inability to characterize matrix development with the required chemical and structural details during the CAVD process. I aim to push our capability for in situ imaging of ongoing biological matrix formation processes from the micron to the nanometer scale by creating a designer tissue imaging platform for CAVD. This will be achieved by: • creating a human CAVD-on-a-chip that allows the application of mechanical and (bio)chemical cues to accurately emulate the early stages of CAVD; • designing the chip to accommodate a 3D correlative multiscale imaging and spectroscopy workflow to study matrix modification and mineralization in the native state from the micrometer to the nanometer scale; • developing a method to (1) collect cryo-sections from the ECM created at precisely selected points in space and time, to (2) transfer these to a transmission electron microscope and (3) revive -inside the microscope- the biological processes that are ongoing in the at the moment of cryo-arrest. This will allow for the first-ever dynamic nanoscale imaging of ongoing ECM processes. These new capabilities will allow breakthroughs in understanding the role of matrix interactions in aortic calcification, opening the way for future development of drug-based treatments for CAVD.

Keywords: electron microscopy,correlative microscopy,volume em,3d cryoem,in situ em,raman microscopy,biomineralization,organ on a chip,aortic valve calcification,collagen
REmote Sensing INtegration For Optimized Resource Management: Scaling farm water balance toolbox for mapping the water productivity and sustainability of the Australian agricultural sector (REINFORM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Research and Innovation actions
Countries involved: Portugal,Netherlands,Germany,Australia
Call: Designing space-based downstream applications with international partners (HORIZON-EUSPA-2023-SPACE, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 1397026.43
EU funding (EUR): 998944.0
Participants: 6
Project status: SIGNED

Droughts are worsening due to changing climate, affecting all reliant on water resources. Since agriculture is by far the largest consumer of freshwater, sustainable production practices are the only way forward to mitigate the most severe impacts on the local environment, which is also acknowledged by the Australian agricultural sector. Scalable and transparent methods to report on the water productivity and sustainability are needed to allow agriculture industries to continuously improve their productive and sustainable water use. However, local reporting initiatives using in-situ data are labour-intensive, costly, and not scalable. Therefore, we aim to inform the Australian agricultural sector on the advances in EO-based water productivity and sustainability reporting. We will accomplish this by integrating state-of-the-art EO-based estimates on irrigation and precipitation and alternatives to locally sourced inputs with advanced hydrological models. Contrasting to most existing EO-based water productivity and sustainability indicators, we aim to include most of the intricacies of irrigation systems and the consequent losses that occur during the application of irrigation, enhancing the reliability of the indicators. The proposed system will not only deliver these indicators for the entire Australian continent but also provide transparency on each of the components used to calculate the indicators. Although we will focus on the entire Australian irrigated agricultural sector, we have a particular interest in the Namoi and Murrumbidgee River valleys where we have already established lasting relationships with local stakeholders. The REINFORM consortium is well experienced in leading and implementing EU funded projects. With 4 research focussed SMEs, a private sector company and a university, we have the scientific depth needed for research and development, as well as the commercial insight and flexibility needed to meet market demand beyond REINFORM.

Keywords: water productivity,sustainability,irrigated agriculture,hybrid hydrological modelling,sustainability indicators reporting
Development of two-dimensional transition metal compound based efficient electrocatalyst for green H2 production (2DTMCH2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-02-28
Duration (months): 25.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: CLOSED

The rapid progress in intermittent solar, wind technologies has created an urgent need to develop parallel technologies of storing energy in forms that are suitable for on-site applications as well as long distance transmission. The present method of storing the surplus energy in batteries is not a viable solution in the long run, owing to the limited reserves and toxicity of battery materials. In such a scenario, storing the obtained energy in the form of H2 fuel is a fairly attractive strategy. Alkaline water electrolyzer (AWE) have been a key technology for large-scale hydrogen production and are capable of generating energy in MW range. Alkaline water electrolyzer (AWE) still requires technological make-over to reach the desired efficiency of about 90 % from the current 70 %. On the other hand, counterpart technology of proton exchange membrane (PEM) water electrolyzer is highly efficient, but its investment cost and low lifetime limits commercialization. The investment cost of AWE today is around 1000-1200 $/kW, and PEM is 1700-2500 $/kW. In addition, the lifetime of AWE is higher and the annual maintenance costs are lower compared to PEM. Although AWE has an economic advantage over PEM, integrating AWE with an intermittent energy source of solar and wind power requires a major advancement in the design to be used in dynamic operating conditions. The key objective of this research is to develop a multipurpose low-cost water electrolyzer for H2 production by electrolysis of alkaline-water with special focus on seawater (alkaline) water to store intermittent energy sources (solar and wind) in form of clean fuel. Unfortunately, there are no commercial electrolyzer that run on seawater, owing to the associated research and technical challenges of high activity, OER selectivity, stability, and low cost. The present project aims to develop AWE stacks for H2 production employing efficient, cost-effective two-dimensional transition metal compounds (2D-TMC).

Keywords: electrolysis,hybrid 2d systems,transition metal,layered compounds
Deep Programmability and Secure Distributed Intelligence for Real-Time End-to-End 6G Networks (DESIRE6G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Netherlands,Hungary,Israel,Türkiye,Greece,Belgium,France,Spain,Finland,Italy,Germany
Call: System Architecture (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 6211893.75
EU funding (EUR): 5874905.0
Participants: 17
Project status: SIGNED

Over the past decades the mobile communications has evolved over the different generations to the current 5G, and transformed into a fundamental infrastructure that supports digital demands from all industry sectors. However, 5G systems are expected to fall short on meeting the anticipated stringent performance requirements for the new generation of real time mission-critical applications. In view of that, DESIRE6G will design and develop novel zero-touch control, management, and orchestration platform, with native integration of AI, to support eXtreme URLLC application requirements. DESIRE6G will re-architect mobile networks through a) its intent-based control and end-to-end orchestration that targets to achieve near real time autonomic networking; and b) a cloud-native unified programmable data plane layer supporting multi-tenancy. The latter will be supported by a generic hardware abstraction layer designed for heterogeneous systems. Flexible composition of modular micro-services for slice specific implementations and flexible function placement depending on HW requirements will enable granular use case instantiation and service level assurance with minimum resource consumption and maximum energy efficiency. The DESIRE6G data, control, management, and orchestration plane is supported by a pervasive monitoring system, extending from the network to the user equipment or IoT terminal. DESIRE6G will employ distributed ledger technology to support a) dynamic federation for services across of multiple administrative domains and b) infrastructure-agnostic software security. Finally, DESIRE6G will enable communication-, and energy- efficient distributed AI, at the network edge, while considering application-level requirements and resource constraints. The proposed innovations will be validated employing a VR/AR/MR and a Digital Twin application at two distinct experimental sites.

Keywords: serverless computing,programmable data plane,multi agent systems,blockchain,software security,extreme urllc
Cell mechanics of megakaryocytes in 3D tissues - deciphering mechanobiology of platelet formation (MEKanics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1497550.0
EU funding (EUR): 1497550.0
Participants: 2
Project status: SIGNED

Homeostatic platelet counts are crucial for vascular integrity and vital to life. Megakaryocytes (MEKs) are giant hematopoietic cells forming large protrusions that fragment to constantly replenish the circulating platelet pool. Nevertheless, severe blood loss, sepsis and aggressive cancer therapies, often cause critically low platelet levels - a major public health problem in Europe's aging population. Despite the unmet clinical need to control platelet production, there is a major lack of knowledge about the mechanistic cell biology of MEKs, hampering the development of innovative therapies. MEKanics will go beyond the state of the art and proposes a combined cell biological and biophysical approach to study MEKs in physiological tissue environments to uncover the mechanical principles that drive platelet formation. I will use quantitative microscopy to characterize cytoskeletal dynamics of MEKs confined in 3D environments of controlled adhesiveness, geometry and stiffness to reveal the mechanisms of force generation and transmission critical for MEK protrusion formation. Further, I will explore how protrusion mechanics affect cytoplasmic transport and partitioning of organelles required for functional platelets. Using super-resolution intravital imaging, I will investigate these processes in their physiological bone marrow niche. By integrating scRNAseq and live-cell microscopy, I will map morpho-dynamics with transcriptomics to identify the gene signature initiating protrusion formation of MEKs in response to mechanical stimuli. A novel MEK cell-system with optimized access to genetic manipulations will allow high-throughput screening of candidate genes. Together, the unique combination of genetics, engineering, quantitative microscopy and intravital tools will provide a holistic cell mechanical model of MEKs in 3D tissues paving the way for new therapeutic approaches to control platelet formation and to advance devices for large-scale platelet production.

Keywords: cell motility,force transmission,actin dynamics,platelets,thrombopoiesis,megakaryopoiesis,cellular confinement
Error Correcting Codes for Interactive Channels (InterCoding)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2027-01-01
End date: 2031-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Error Correcting Codes (ECCs) address a fundamental question: how can we ensure reliable data transmission over unreliable channels? Since Shannon’s pioneering 1948 work, seven decades of research have created a rich theoretical framework with practical impacts across diverse fields. Today, communication systems are no longer just about transmitting information. Instead, they often involve interactive processes requiring multiple exchanges between participants, as seen in cloud computing, cryptographic protocols, and distributed systems. \begin{quote} \textbf{This proposal focuses on crafting interactive error-correcting codes and uncovering their fundamental limits.} \end{quote} Our research revisits the fundamental ECC problems in interactive contexts, aiming to address key challenges, including: \begin{enumerate} \item Determining the rate-distance trade-off for reliable data transmission. \item Investigating rate-distance trade-off for general interactive protocols \item Developing error-resilient protocols for distributed computing. \end{enumerate} We will explore both classical questions in interactive communication and uniquely interactive challenges, including the creation of adaptive coding schemes with enhanced performance over static alternatives. By integrating concepts from diverse fields, this work seeks to advance the interdisciplinary understanding of error correction in interactive settings. Given the success of classical ECCs and the growing importance of interaction in modern applications, we are confident that advancing the theory of \textbf{interactive error-correcting codes} will drive transformative progress.

Keywords: error correcting codes,information theory,interactive communication
Training AlliancE for Novel Microbiome-Modulating TherapieS (TALENTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany,France,United Kingdom,Austria,Belgium
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1512000.0
EU funding (EUR): 1512000.0
Participants: 17
Project status: SIGNED

TALENTS aims to build up an international programme for interdisciplinary and transsectorial training of 15 doctoral candidates (DCs) as needed for the next generation of drug researchers. Research projects are structured in 3 clusters (PCs): PC1 will investigate the microbiome by transcriptomic and metagenomic analysis of diseases to identify and isolate microorganisms/metabolites for therapeutically modifying the microbiota. PC2 will focus on pathoblockers targeting virulence factors as alternative to traditional antibiotics with lower risk of resistance development. PC3 will address the delivery needs across biological barriers, to achieve efficient and targeted transport to the site of action. Throughout the PC structure of 15 individual, but interconnected research projects, we aim to develop and exchange disease models, analytical methods and microbiome-related results. By generating knowledge on correlations and causalities between microbiota and disease TALENTS will advance the development of novel microbiome-modulating therapies TALENTS is builds on an earlier joint venture of Saarland University, University Clinics Saarland and Helmholtz Institute for Pharmaceutical Research Saarland to foster transdisciplinary doctoral training between different faculties and institutions. In addition, TALENTS is intersectorial by implementing a unique supervision structure for each DC with an external expert advisor and translation-oriented training for individual career development, also including secondments in a complementary industrial or clinical sector. Working on challenging research projects, the candidates will acquire specific knowledge and skills at the interface of clinical medicine, microbiology and pharmaceutical science, pivotal for state-of-the-art infection research and microbiome interventions. By collaborations of experts from natural sciences, medicine, and bioinformatics, TALENTS provides high-level multidisciplinary and intersectorial training.

Keywords: microbiome drug discovery and development anti infectives natural products antivirulence drug delivery
DPP9 degradation-induced pyroptosis for treatment of acute myeloid leukemia (DPP9-TACDrug)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

Dipeptidyl-peptidase 9 (DPP9) is a proline-selective serine protease that belongs to the peptidase S9 family. During recent years, DPP9 inhibition has shown to cause pyroptosis, selectively in acute myeloid leukemia cells. Pyroptosis is a lytic form of programmed cell death, that has mainly been observed in immune cells. The process typically recruits and activates other immune cells and inflammatory mediators, causing a localized activation of the innate immune system. This is particularly appealing for leukemia treatment, because the immune-response to leukemic cells is typically severely subdued. Recent mechanistic insight suggests that native DPP9 suppresses pyroptosis through a stabilizing protein-protein interaction (PPI) with the NLRP1 inflammasome sensor. Furthermore, DPP9 inhibition with small molecules only has a mildly destabilizing effect on the [DPP9-NLRP1] PPI. This proposal suggests the targeted clearance of DPP9 from the cytoplasm in acute myeloid leukemia cells to cause pyroptosis through enhanced NLRP1 activation. PROTACs and AUTACs are heterobifunctional molecules that mediate the degradation of a protein of interest (POI) by hijacking cell’s own proteasome and autophagic system, respectively. The implementation of PROTAC and AUTAC technologies for targeted clearance of DPP9 and consequent pyroptosis induction in acute myeloid leukemia cell lines is proposed in this project. PROTAC and AUTAC molecules will be designed and synthesized, followed by in vitro evaluation of their cell permeability, DPP9-engagement, DPP9 clearance potency and selectivity, and dose/time dependence of DPP9 clearance. Furthermore, a comparison of the pyroptosis signatures of PROTACs, AUTACs and DPP9 inhibitors will be performed. Overall, this proposal can provide a superior therapeutic strategy to AML and other cancer types.

Keywords: autac,dpp9,protac,pyroptosis
A grant to support the Mission Director and the Annual Innovation Summit of the Urban Transitions Mission under Mission Innovation (MI UTM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: Global Mission on Urban Transitions under Mission Innovation (HORIZON-MISS-2022-CIT-IBA, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 420106.25
EU funding (EUR): 349500.0
Participants: 1
Project status: CLOSED

A grant to support the Mission Director for the Urban Transitions Mission under Mission Innovation, co-led by the European Commission DG Research and Innovation (RTD), the Global Covenant of Mayors for Climate and Energy (GCoM), and Joint Programming Initiative - Urban Europe (JPI UE). This grant covers the resources required to appoint the Director for an initial two-year period - including overhead costs - as well as travel and external event engagements. It also contains a contribution towards conceptualization, development, and execution of the planned Annual Innovation Summit under the Urban Transitions Mission: a gathering of clean energy and net-zero leaders across national governments (and the European Commission), cities and local governments, businesses, academia, and civil society.