Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modulating Drug Transporters Dynamics to Improve Therapeutic Efficacy (DynamITE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1671339.0
EU funding (EUR): 1671339.0
Participants: 1
Project status: SIGNED

The therapeutic effect of a drug is largely determined by how effectively it reaches its site of action. Drug distribution in the human body is defined by an intricate network of transporters, offering potential for dynamically controlling where a drug spends most of its time. DynamITE aims to provide the tools to manipulate this "highway network" of drug transport at will. DynamITE will exploit the common mechanism shared by transporters, that is the alternating-access. Every transporter must dynamically switch between different states to enable directional transport of its substrate through the biological membrane. At the molecular level, this involves important local and global changes in the protein's three-dimensional structure. The foundational methodology of DynamITE is a structural mass spectrometry approach that reports on such changes: hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS). I have demonstrated that HDX-MS can fingerprint the effects of drugs on the dynamic switching between states. DynamITE builds on this knowledge to identify and design modulators of transporter dynamics. A modulator that prevents the conformational changes underlying transport will block drug transport, while a modulator that increases the rate of conformational transitions will accelerate transport. DynamITE’s approach will be applied to selected drug transporters with proven critical roles in antibiotic resistance, drug toxicity, and drug transport into the brain. In parallel, DynamITE will advance the HDX-MS technique to make it applicable to living cells. Such a development will enable the observation of protein dynamics in cellulo, with a molecular level of resolution—something currently inaccessible. This methodological breakthrough be used to monitor drug transporters dynamics while in action within the cell. The toolbox developed within DynamITE will be applicable to any transporter for which targeted modulation of transport activity is desired.

Keywords: protein dynamics,transmembrane transport,drug transport,drug distribution,h d exchange mass spectrometry,nanobodies,solute carriers
The Role of Green Quantitative Easing for Optimal Climate Change Policies (GREENQE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

The United Nations Sustainable Development Goal 13 calls to "Take urgent action to combat climate change and its impacts" by 2030. This call to take action also reached central banks: A controversial debate of whether monetary policy shall target climate change mitigation is ongoing. This addresses also the use of titling the asset purchase programs towards green assets (green quantitative easing, green QE). GREENQE contributes to this discussion, by investigating how large of a carbon emission and temperature reduction could be achieved by tilting the corporate asset portfolio of central banks around the world towards green assets. Benefits from slowing down climate change are contrasted with costs from possible impediments to the monetary transmission channels. These costs and benefits are quantified using a rich integrated assessment model with incomplete markets and aggregate risk, featuring a green and brown sector of production, asset markets and fiscal and monetary authorities. This allows to evaluate the trade-offs of greening central banks' asset purchases (climate change mitigation vs. impeding monetary transmission mechanisms) as well as to investigate whether a monetary policy focused on the business cycle horizon can be used effectively to address a slow-moving climate change process. The results of GREENQE are of interest to various stakeholders, including foremost central banks as well as governments. If green QE is found to be an effective and not-costly tool it might be used to complement green fiscal policies of national governments and supranationals like the EU commission.

Keywords: climate change monetary policy green quantitative easing carbon taxation integrated assessment model
Advanced systems and soLutions for Better practices AgainsT hazaRds in the aviatiOn System (ALBATROS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Netherlands,Germany,France,Italy,Switzerland,Slovenia,Spain,Finland,Greece,Portugal
Call: More resilient aircraft and increased survivability (HORIZON-CL5-2022-D6-01, 2022)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 9571160.5
EU funding (EUR): 8328635.0
Participants: 22
Project status: SIGNED

ALBATROS overarching ambition is to maintain a high level of safety in aviation in view of extreme weather conditions, expected changes brought about by the evolution of aviation systems especially new fuel and energy systems (including hydrogen) which will be integrated in the coming years to both future aircraft and airport infrastructures. ALBATROS activities target the increased resilience against safety issues both on the ground and in flight to ensure the survival of passengers and crew as well as their evacuation and rescue in case of emergencies. ALBATROS objectives are to: - Develop a concept for real‐time sharing of safety intelligence to support decision making on safety issues, emergencies and crises; - Develop safety risk models and analyse safety data for prediction and prevention of emerging and future hazards in aviation (linked to Data4Safety); - Develop survivability measures to mitigate safety issues and risks; - Assess and improve human performance and develop best practices for decision making in the handling of crises and emergency situations; - Validate and demonstrate concepts, technologies and decision support tools (exercises at airports, simulations and laboratory tests conducted in close collaboration with EACCC, GADSS and ACI-Europe); - Disseminate, communicate, and exploit project key results and outcomes (including through emergency response training & exercises). ALBATROS will work on maturing technologies and solutions up to TRL6 which will be compatible with EACCC and GADSS requirements. Initially, scenarios, requirements, concepts of use and relevant technologies will be agreed upon, before development activities are performed on safety modelling and data analysis, survivability as well as decision support tools and best practices. The results of these developments will then be integrated and validated through 15 demonstrations in relevant environments across Europe (airports, flight simulators or crisis centres).

Keywords: survivability,safety,resilience,weather hazards prediction,hydrogen,electrical energy systems,aircraft tracking,aircraft,airports,ground handling,fire prevention,emergency response,rescue
DeConstruct Stars: revealing the enigmatic mixing process in the radiative-convective boundary of stars using cutting-edge 3D numerical simulations (DCStars)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: SIGNED

Stars like our Sun are complex systems in which hydrogen fusion occurs in the radiative core, and heat is transported by convection in the outer part. The two most important regions in Sun-like stars are the optical surface and the transition region between the radiative core and the convective envelop, called the tachocline. The tachocline, which is believed to be responsible for generating stellar global magnetic fields (also related to the 11-year solar cycle), is a complicated region where the effect of rotation, magnetic field, diffusion of elements, and convective overshoot interplays. In this project, we will carry out global convection simulations that range from radiative interior to the lower atmosphere for the Sun and a few F-type stars using the state-of-the-art DISPATCH code. Our ab initio simulations will include complex physical processes such as rotation and magnetic fields and are free from approximations typically adopted in previous works. Based on these simulations, the applicant will quantitively study the problem of overshooting and gravity wave excitation near the tachocline, which are crucial for a better understanding of the solar modeling problem, the anomalous abundance of lithium in the Sun, and the cosmological lithium problem.

Keywords: hydrodynamics,stellar interiors,turbulence,overshoot,waves
A quantitative study of periodic patterning in growing multicellular tissues: understanding trichome development (PaTrich)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

The development of living organisms involves tightly coordinated regulatory mechanisms that reliably instruct each cell type, tissue, and organ to perform specific functions. This is achieved through an elaborate interplay between pattern formation, cellular growth, and division. Patterning processes occurring as cells grow and divide are present in many biological systems. These include the generation of digits in the vertebrate limb and the specification of trichomes in the leaf epidermis of Arabidopsis, among many other examples. Still, the effect of cellular growth and division on pattern formation remains poorly understood. Because of the difference in time scales, pattern formation, and growth have been typically studied separately; however, in many developmental processes, these two time scales are comparable, and the effect of growth on patterning must be considered explicitly. In this project, I will combine quantitative image analysis, mathematical modelling, and computer simulations to understand the interplay between cellular patterning and growth, by focusing on trichome development. Trichomes constitute an optimal model to test fundamental principles of pattern formation in growing tissues, because there is a good understanding of the underlying gene regulatory networks, and the pattern formation process can be tracked over time. This project will be developed in collaboration with leading experts in the field: the Hülskamp lab, providing the experimental data, and the Fleck lab, providing the theoretical expertise in the regulatory networks underlying trichome patterning. The findings resulting from this project will elucidate general principles of pattern formation in plants and other living organisms during tissue growth.

Keywords: quantitative plant biology,pattern formation,theoretical biology,image analysis
Boronic Acids as a New Strategy to Boost beta-Lactam Antibiotics for the Treatment of Tubercolosis (BAN-BOOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-16
End date: 2026-05-15
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 3
Project status: SIGNED

Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb), one of the most dangerous aerobic bacteria. The need for long-term treatments and the increase in drug resistance mechanisms make it necessary to urgently develop new strategies to combat this potentially lethal pathogen. beta-Lactam Antibiotics (BLA) are the most widely used and safest antibiotics in the clinic and include several classes such as penicillins, cephalosporins and carbapenems. However, historically these agents have not been used to treat TB. There are two mechanisms of resistance to BLA in Mtb: the cell envelope rich in lipoglycans which acts as a barrier for the penetration of many drugs, including BLA, and the expression of BlaC, a specific beta-lactamase enzyme capable of hydrolyze and inactivate the BLA. Recent studies have shown that the combination of meropenem (a beta-lactam carbapenem), amoxicillin (a beta-lactam penicillin) and clavulanate (a beta-Lactamase inhibitor) markedly reduced the Mtb load in the patient’s sputum after two weeks, therefore giving new hope to the use of BLA to tackle the tuberculosis epidemic. This proposal aims to develop new compounds that behave as BLA adjuvant for anti-Mtb treatment with a dual mechanism of action. We will design and synthesize novel Boronic Acid Transition State Inhibitors (BATSIs) as inhibitors of BlaC, the beta-lactamase expressed in Mtb, and investigate whether they can be derivatized to become disrupting agents of Mtb’s unique outer “capsule” made of lipoglycans, to promote better penetration of drugs into the cell. This project will also investigate the possibility of improving the penetration of molecules into the necrotic granuloma formed in vivo as part of the disease process, by developing a lipid-based prodrug strategy. To achieve these specific objectives, the project will be divided into three main work packages, involving a combination of biological, chemical, and analytical expertise.

Keywords: mycbacteria,antimicrobial resistance,beta lactamase inhibitor,boronic acids,prodrugs
World’s first diagnostic test that can detect all bacterial species in a single assay (Molecular Culture)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 4550314.69
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Every year, bacterial infections cause 20% of human deaths. These deaths can be avoided only if the patients are administered correct medical treatment without any delays. Today, the diagnostic tests used to detect and identify bacteria are too slow or not comprehensive enough. Often, doctors have no other option, but to administer treatment through antibiotics based on educated guesswork which can lead to medical complications, in addition to increased patient care costs. To address these issues, Inbiome is developing a cost-effective diagnostic test called “Molecular Culture” which detects and identifies all bacterial species with 100% accuracy and delivers results within 4 hours. During the EIC project, Inbiome will perform an implementation trial of Molecular Culture in a live hospital setting, optimizing the interface for hospital workflows, clinical validation of additional sample types, adding Anti-Microbial Resistance testing in the workflow, and expanding commercial skills.

Keywords: well being,healthcare system,diagnostics,bacterial infections,microbiology
A Vaccine Targeting Eradication of Malaria (UltiMalVax)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Portugal,Sweden,Switzerland,United Kingdom
Call: Vaccines 2.0 - developing the next generation of vaccines (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 2620000.0
EU funding (EUR): 2620000.0
Participants: 9
Project status: SIGNED

Malaria killed about 640 thousand people in 2020, largely young children in Africa. Rapid recent progress has led to two anti-sporozoite vaccine developers planning WHO prequalification applications in 2022. These include the new high efficacy R21/Matrix-M vaccine, to be supplied at the required large scale, and led by partners in this consortium. In parallel, recent progress with transmission-blocking malaria vaccines has led to substantial efficacy in a first direct skin feeding field trial. This opens up the prospect of a two-stage vaccine targeting both sporozoites and sexual-stage parasites that should have a major impact on malaria transmission, thereby enabling regional elimination and ultimate eradication. We propose here to develop such a vaccine assessing both established virus-like particle (VLP) vaccines in potent saponin adjuvants and also exciting new thermostable mRNA vaccines expressing the parasite antigens now showing high efficacy. Importantly, we will adopt new VLP design technologies, e.g. SpyCatcher bonding, that allow bivalent antigen display, to enable a single vaccine to protect against both the Plasmodium falciparum parasite, which causes most deaths, and the more widespread Plasmodium vivax parasite. A lead vaccine candidate will be down-selected based on well-studied pre-clinical efficacy models and induction of functional transmission-blocking antibodies, prior to GMP manufacture and a clinical trial in year 4. The consortium brings together academics, non-profits and a wide range of companies with both leading technologies and access to small and very large scale GMP manufacturing capacity. This programme builds on the recent success of several partners in the R21/Matrix-M programme and aims to accelerate the malaria eradication agenda by providing the first vaccine to tackle both major malaria parasite species, and confer both individual and community protection on the way to eradication.

Keywords: vaccine,malaria,falciparum,vivax,eradication
Using Artificial Intelligence to Support Regulators & Policymakers (AI4POL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,United Kingdom,Lithuania,Italy
Call: Beyond the horizon: A human-friendly deployment of artificial intelligence and related technologies (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3005795.0
EU funding (EUR): 3005795.0
Participants: 7
Project status: SIGNED

AI-innovation in Europe lags behind the US and China. To catch up and ensure pro-European outcomes, AI-regulation constitutes the EU’s main channel to shape the future of AI-development globally. This project will support European regulators and policy makers with knowledge and tools to adequately address challenges and opportunities of trustworthy and ethical AI and to develop and enforce effective regulation of AI based on human rights, European values, and citizens' needs. AI4POL will explore how regulators can use data science and AI-driven tools to improve monitoring and enforcement of regulations such as the Data Act, the Digital Markets Act, the AI Act and in consumer law. To this end, we will focus on a key innovation area, financial services, and how to increase AI-enhanced understanding and citizen feedback for the informed regulation of digital services by developing a large language model for legal jargon translation and a browser-plugin for user feedback about their understanding of laws. We will also analyze how to create and regulate trustworthy AI for financial services, for example with robo-advisors or credit scoring. Taking a long-term, geopolitical perspective, we will develop an early-warning system regarding high-risk AI in autocratic states, including the development of an AI Threat Index and dashboard and piloted with the cases of China and Russia. AI4POL pursues these objectives with a multidisciplinary, diverse research team, combining substantive expertise in AI/data science, ethics, law, economics, and political science with project management resilience, quality assurance and timeline monitoring, and risk-based intervention plans. The consortium has extensive experience in advising policy makers and has reliable contacts to various stakeholders, evidenced by AI4POL’s Advisory Board comprising EU- and national regulators and policy makers, consumer protection agencies, civil society organizations, and AI-firms.

Keywords: ai governance,regulators,competition policy,trustworthy and ethical ai,financial services,autocratic states,long term threats of ai