Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Strengthening and Energizing EU-Central Asia relations (SEnECA)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Coordination and support actions
Countries involved: Uzbekistan,Germany,Germany,Belgium,Poland,Latvia,France,United Kingdom,Kyrgyzstan,Kazakhstan,Turkmenistan,Tajikistan
Call: The European Union and Central Asia (H2020-SC6-ENG-GLOBALLY-2017, 2017)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 1499857.0
EU funding (EUR): 1499857.0
Participants: 12
Project status: CLOSED

The relations to Central Asia are an important element of the changing transatlantic and geopolitical setting the EU is currently facing. They are influenced by the role the rest of Asia and other world powers play in the region, which the EU has to take into consideration while focusing on its comparative advantages. The main objectives of SEnECA are to strengthen and energize EU-Central Asia relations by establishing a sustainable, transdisciplinary SEnECA Research Network and the SEnECA Stakeholder Network to link European and Central Asian researchers, policy makers and stakeholders in order to improve research cooperation to develop a common SEnECA Agenda for Future Research Cooperation and EU’s Central Asia policy by setting up the SEnECA Policy Roadmap. The SEnECA Communication Plan for dissemination and awareness-raising will promote the importance of Central Asia to Europe among scholars, policy-makers, stakeholders in education, media, civil society and the EU public sphere notably through the SEnECA Exhibition. SEnECA will thus ultimately strengthen capacities in research and policy advice through the SEnECA Academic Policy Advice Training. Within two years, twelve consortium members from think tanks, universities and NGOs in Europe and Central Asia build on their Trans-European and Central Asian network with research institutions in 41 European, Central Asian and other Asian countries. Through its activities, SEnECA maps existing networks of researchers of Central Asian Studies in Europe and European Studies in Central Asia and key actors in education and media active in EU-Central Asia relations to analyse research cooperation, policies and communication on Central Asia to set up the SEnECA Research Database which forms the basis for recommending priorities and new forms of scientific cooperation following the “blended research” approach and demand-driven policy advice based on an inclusive approach to EU policy-makers and stakeholders active in EU-Central Asia relations.

Keywords: central asia,kazakhstan,tajikistan,uzbekistan,kyrgyzstan,turkmenistan,eu central asia relations,networking and policy advice,improved relations in a new global setting
The functional interaction of EGFR and beta-catenin signalling in colorectal cancer: Genetics, mechanisms, and therapeutic potential. (BEAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2023-09-30
Duration (months): 72.0
Total project cost (EUR): 1793421.0
EU funding (EUR): 1793421.0
Participants: 1
Project status: SIGNED

Monoclonal antibodies against the EGF receptor (EGFR) provide substantive benefit to colorectal cancer (CRC) patients. However, no genetic lesions that robustly predict ‘addiction’ to the EGFR pathway have been yet identified. Further, even in tumours that regress after EGFR blockade, subsets of drug-tolerant cells often linger and foster ‘minimal residual disease’ (MRD), which portends tumour relapse. Our preliminary evidence suggests that reliance on EGFR activity, as opposed to MRD persistence, could be assisted by genetically-based variations in transcription factor partnerships and activities, gene expression outputs, and biological fates controlled by the WNT/beta-catenin pathway. On such premises, BEAT (Beta-catenin and EGFR Abrogation Therapy) will elucidate the mechanisms of EGFR dependency, and escape from it, with the goal to identify biomarkers for more efficient clinical management of CRC and develop new therapies for MRD eradication. A multidisciplinary approach will be pursued spanning from integrative gene regulation analyses to functional genomics in vitro, pharmacological experiments in vivo, and clinical investigation, to address whether: (i) specific genetic alterations of the WNT pathway affect anti-EGFR sensitivity; (ii) combined neutralisation of EGFR and WNT signals fuels MRD deterioration; (iii) data from analysis of this synergy can lead to the discovery of clinically meaningful biomarkers with predictive and prognostic significance. This proposal capitalises on a unique proprietary platform for high-content studies based on a large biobank of viable CRC samples, which ensures strong analytical power and unprecedented biological flexibility. By providing fresh insight into the mechanisms whereby WNT/beta-catenin signalling differentially sustains EGFR dependency or drug tolerance, the project is expected to put forward an innovative reinterpretation of CRC molecular bases and advance the rational application of more effective therapies.

Keywords: colorectal cancer,targeted therapy
Spatiotemporal multimode complex optical systems (STEMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy,Italy
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-11-01
End date: 2023-04-30
Duration (months): 66.0
Total project cost (EUR): 2084180.82
EU funding (EUR): 1513697.71
Participants: 2
Project status: SIGNED

The STEMS project is about exploiting the new concept that has been recently introduced by the PI and his co-workers, namely the self-control of the spatial coherence of optical beams in multimode nonlinear optical fibers. This concept will enable a breakthrough technology, capable of delivering high-energy optical pulses with high-average powers and much higher beam quality from fiber lasers than what is possible today. High-power fiber lasers are largely limited by transverse mode instabilities, and the loss of spatial coherence in delivery fibers. Optical fibers provide the backbone of today’s internet communication networks, and enable compact, low cost light sources for a variety of industrial and biomedical applications. In most of these applications, single-mode fibers are used. Replacing single-mode fibers with multimode fibers leads to a dramatic growth of transmission capacity, and a substantial increase of average power and pulse energy from fiber lasers. However, because of spatial dispersion and resulting mode interference, multimode fibers suffer from an inherent randomization of the spatial transverse beam profile, leading to a loss of spatial coherence. My approach is to exploit the intensity dependent refractive index, or Kerr nonlinearity, of glass fibers to recover the spatial coherence of a multimode wave, and compensate for temporal modal dispersion. First, I propose to develop methods to control fiber nonlinearity, to compensate for temporal and spatial dispersion, thus preventing information spreading in the temporal domain, and coherence loss in the spatial domain. Second, by adding rare-earth dopants to multimode fibers, I will demonstrate self-control of modal dispersion and beam quality in active multimode fibers. Third, via the spatio-temporal control of beam propagation, I will introduce a new fast saturable absorber mechanism for the mode-locking of high-power fiber lasers, analogous to Kerr-lens mode-locking with bulk crystals.

Keywords: optical fibers
Molecular and functional evolution of human CD8+ T cell repertoires (TC-Evo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2021-07-13
Duration (months): 36.0
Total project cost (EUR): 249179.4
EU funding (EUR): 249179.4
Participants: 2
Project status: CLOSED

Humans are equipped with a sophisticated immune system, especially adaptive immunity, which is characterized by the finest antigen specificity. The evolution of such fine antigen specificity across human lifespan is far from being known, although it is observe that the strength of the adaptive immune response varies throughout human lifetime. Published data suggest that T cells receptors (TCRs) continuously change their characteristics. I aim to provide fundamental knowledge on the evolution of T cell repertoires during immunologically-distinct phases of human lifetime by dissecting the evolution of the influenza virus-specific T cell repertoire in children, adults and elderly at the greatest level of resolution and technological innovation and link this to their TCR characteristics. At the Peter Doherty Institute, Melbourne, Australia, I will use state-of-the-art comprehensive immunological analyses to identify molecular switches, which I will use to establish an immunological model to predict the strength of the CD8+ T cell response. I will bring this cutting-edge multi-disciplinary platform to Europe (Sanquin, Amsterdam, The Netherlands) where I will use this platform to study the underlining mechanisms that drive tissue residency of T cells. I will gain knowledge and skills on studying TCRs, tissue resident T cells, bioinformatics and structural biology, while working in close collaboration with world-renowned experts in the field, namely Profs. Kedzierska, van Lier, Luciani, Gras, Beyer and Schulze. These state-of-the-art comprehensive immunological analyses will inevitably yield important insights into protective vs detrimental human immune responses, which will aid early interventions, treatment and help understand and overcome technical challenges of developing broadly-protective vaccines. The MSCA will strengthen my position as an independent researcher and will greatly increase my chances for a tenure-track/fixed position at an European research institute.

Keywords: virology,immunology,evolution,cd8 t cells,influenza,bioinformatics,t cell receptors tcr,aging,tissue residency,molecular gene profiles,honeymoon period of superior immunity
Cross-Linguistic Influence of Competing Knowledge (CLICK): Comparative Morphosyntactic Variations in Heritage Language Development (CLICK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 202158.72
EU funding (EUR): 202158.72
Participants: 1
Project status: CLOSED

Due to increasing global mobility, research into how immigrants acquire and use multiple languages has become a major topic in the past few decades. However, comparatively little is known about how the developmental trajectories of native minority languages (i.e. heritage languages (HLs)) are shaped alongside the societal languages in their children who are heritage speakers (HSs). The CLICK project, as the first study to investigate how different societal languages leave their traces on the developmental trajectories of the same HL, will make a significant contribution to an emergent subfield of bilingualism, namely Heritage Language Bilingualism (HLB). This will be done by studying HSs of Persian/Farsi in contact with two societally dominant languages in France and Spain. We will innovatively combine offline and online methodologies to explore whether or not the syntactic status of pronominal subjects (null and overt subjects in the case of Spanish versus overt subjects only as in French) affects the development and maintenance of related properties in Persian as a HL. Additionally, we will strive to establish if a novel co-registered methodology which combines online and offline measures in the same task offers a promising test battery to better capture underlying grammars of HSs in different language contact situations. Ultimately, CLICK will generate substantive, empirically informed hypotheses about human language, which within the present context of globalization and increased bi-/multilingualism are likely to achieve a marked scientific impact. Accordingly, the findings of this project will be of interest not only to psycholinguists, sociolinguists and psychologists but also to teachers, speech pathologists, education policy makers and immigrant parents. In addition, the emphasis given to non-standard languages promotes linguistic diversity, concordant with the EU’s efforts to raise awareness about minority languages.

Keywords: bilingualism,heritage speakers,cross linguistic influence,societal languages,language processing,anaphora
Enhancing the Implementation and Monitoring and Verification practices of Energy Saving Policies under Article 7 of the EED (ENSMOV)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Italy,Germany,Belgium,Lithuania,Greece,Poland,Bulgaria,Hungary,Romania,Greece,Croatia,France,Netherlands,United Kingdom
Call: Supporting public authorities to implement the Energy Union (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 1499985.0
EU funding (EUR): 1499985.0
Participants: 16
Project status: SIGNED

ENSMOV will support public authorities and key stakeholders in 14 Member States represented by its consortium (NL, BE, IT, FR, GR, AT, DE, PL, RO, UK, HR, BG, HU, LT) in implementing the Article 7 EED requirements. More specifically it will assist them to monitor, improve and complement the design and implementation of their energy efficiency policies by developing resources on practical issues they face. As the implementation of the Article 7 EED has shown, public authorities have limited time and resources to share experiences at the EU level and, as previous projects (EC IEE ENSPOL, EC H2020 MULTEE, PUBLENEF, EPATEE) demonstrated, the opportunity to share experiences is very welcome by public authorities. To find implementation challenges and solutions for energy efficiency obligations (EEOs) and alternative measures and monitoring and verification (MRV) schemes, ENSMOV has designed an experience sharing programme with a structured set of national, regional and EU workshops to address Article 7 EED requirements. These exchanges are underpinned by technical support to ensure that experience sharing results in positive impacts and actual improvements of policy implementation and monitoring. An important tool for active engagement of public authorities will be the Knowledge Transfer Platform, designed to enable discussion on Article 7 EED implementation issues (updated ENSPOL platform www.article7eed.eu). This programme will cover up to 10 crucial MRV and policy implementation topics and is expected to result in improved capacity of 150 unique participants (at least 45 public officers), at least 30 policies influenced through the action, 14 MS with improved implementation of Article 7 and improved and consistent MRV systems. These will all lead to a smoother transition in the new Article 7 EED era.

Keywords: article 7 energy efficiency directive,monitoring and verification,energy efficiency obligations
Magnetic multifunctional molecules based on 4f and 3d/4f metal complexes (MAGMOLMET)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Romania
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 141778.56
EU funding (EUR): 141778.56
Participants: 1
Project status: CLOSED

The project aims to provide a rational design for the synthesis of 4f homo- and 3d/4f heteronuclear systems and to prove their effectiveness in applications such as information storage, magnetic refrigeration, luminescent materials. The efforts will be focused on the following objectives: synthesis, spectroscopic and structural characterization of new molecular systems based on salicylaldehyde and its derivatives; evaluation of magnetic properties that allows the study of their behavior as nanomagnets (slow relaxation of the magnetization) and the magnetocaloric effect. The choice of the host organization - group from the Department of Inorganic Chemistry of the Faculty of Chemistry, University of Bucharest under guidance of Acad. Marius Andruh is dictated by its internationally recognition in design of original magnetic coordination compounds, expertise in molecular magnetism and use of crystal engineering strategies. The complementary applicant's (Dr. D. Dragancea) experience in synthetic coordination chemistry and characterization gained in the Laboratory of Coordination chemistry of the Institute of Chemistry in Chisinau, Moldova will assure the completion of project objectives. The fellowship provides the opportunity to use equipment and techniques that are not available at home institution, to gain a unique experience on the edge of several disciplines, establish scientific contacts. Altogether will positively impact her long-term career.

Keywords: lanthanide ions,heterometallic,single molecule magnets,synthetic strategies
Nature Self-medication: Poisoning the microbes a Toll for wildlife (NatureSToll)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: SIGNED

Global pharmaceutical consumption is rising with growing and ageing human population and more intensive food production. Recent studies have revealed pharmaceutical residues in aquatic ecosystems and organisms. Among pharmaceuticals, antibiotics, which are natural, synthetic or semi-synthetic compounds, able to kill and inhibit growth or metabolic activity of microorganism, are one of the most widely used categories. Environmental concentrations of antibiotics are often low, but their continuous discharge in the environment, exposes aquatic organisms during their entire life cycle. There is currently little data on the non-therapeutic effects of antibiotics. The microbiota represents the trillions of microorganisms inhabiting a host. Gut microbiota contributes to the development of an immune response, to metabolic processes and it influences the host behaviour. Gut microbiota is very plastic and recent insights have suggested that most diseases could be linked in some way to an alteration of the gut microbiota (i.e. a dysbiosis). However, no studies so far have investigated the impact of antibiotic residues on wildlife’s gut microbiota composition and its effect on disease occurrence. Top predators of aquatic ecosystems such as mustelids are exposed to high levels of pollutants and are considered as keystone sentinel species for the study of pollutant effects on wildlife. Mustelids are also a reservoir species to zoonotic disease, as they are exposed to diverse types of viruses that can be passed from and to domestic animals and humans. The aims of this research action are to 1) determine the ‘natural’ variation of gut microbiota composition according to biological factors, 2) investigate a threshold effect level for which pharmaceuticals could lead to health effects, 3) test if the individuals with high concentrations of pharmaceuticals are more likely to develop infectious diseases. I will investigate these questions in the American mink Neovison vison.

Keywords: ecophysiology,gut microbiota,emerging contaminants,pharmaceuticals,mustelids,zoonotic disease
Long Range Surface Plasmon Polaritons as an Alternative Information Carrier for Nanoscale Quantum Circuitry (QuP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-12-29
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The aim of this innovative and high-impact interdisciplinary proposal is to investigate the potential properties and applications of plasmonic metallic nanostructures that enable the confinement of light to scales beyond the diffraction limit, known as quantum plasmonics. Latest studies have revealed the quantization of surface plasmon polaritons (SPPs). It could be the stepping stone for the generation of miniaturized photonic components for the quantum control of light. This implies that the SPPs would represent a totally new sort of information carrier for nanoscale circuitry, enabling a revolutionary bridge between current diffraction-limited microphotonics and bandwith-limited nanoelectronics, paving the way for integrated quantum information processing. Thus, in a first stage we will develop integrated nanoscale quantum plasmonics building blocks on-a-chip, such as efficient single-photon sources or transistors, which is the component required for the fabrication of true nanoscale quantum computing logic gates. We also plan to exploit the low-Ohmic-losses and prospects for large scale production of ultra-compact cutting-edge graphene plasmonic circuits. This research will be lastly applied to single molecule sensing. Experiments will be performed using innovative techniques for nanofabrication of photonic nanostructures and for characterization. The expected results will allow taking advantage of quantum interference effects, setting up the optical response of the extremely low losses Long Range (LR) SPPs modes within a quantum framework and showing that graphene layers produce strong light-matter interaction and extreme optical field confinement. The results will be compared with ab initio simulations, giving a precise and consistent experimental and theoretical panorama of quantum plasmonics.

Keywords: quantum plasmonics,quantization of long range surface plasmon polaritons,quantum transistor,graphene plasmonic circuits,single molecule sensing