Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The evolutionary ecology of bacterial immune mechanisms (EVOIMMECH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: New Zealand,United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 1498337.0
EU funding (EUR): 1420837.0
Participants: 3
Project status: SIGNED

Bacteria have a range of immune mechanisms, but it is unclear why this diverse armamentarium evolved. The most important immune mechanisms are (1) Surface Modification (SM) (2) Abortive infection (Abi) (3) Restriction Modification (R-M) (4) CRISPR-Cas and (5) prokaryotic Argonaute (pAgo), all of which can occur as stand-alone mechanisms or in combination. The individual mechanisms differ in key aspects, such as their fitness costs (constitutive versus inducible), specificity (indiscriminate versus specific), the recipient of the benefits (individual versus group), the speed of de novo resistance evolution (rapid versus slow), and heritability of immunity. Here I will take a combined in vitro and in vivo approach to tease apart the variables that drive the evolution of these diverse stand-alone and integrated bacterial immune strategies in nature, and examine their associated co-evolutionary dynamics. I focus on three ecological variables that are consistently important in host-symbiont co-evolution: (1) force of infection (2) spatial structure (3) presence of mutualists (plasmids). First, I will perform in vitro manipulations using Pseudomonas aeruginosa PA14 variants that carry either single or multiple immune mechanisms. Next, I will sequence metagenomes, transcriptomes and viromes of microbial communities from environments that differ in ecological variables that are important in vitro, to examine their importance in vivo. Key ecological mechanisms identified in the first two parts of the project will be used to guide mesocosm experiments to experimentally confirm that these mechanisms are the drivers of the observed patterns of resistance and co-evolution in nature. Finally, I will share my data with mathematical biologists to generate theoretical models to predict and manipulate the evolution of bacterial immune mechanisms, which will facilitate tailored species protection in agriculture and industry.

Keywords: bacteria,phage,plasmid,surface modification,restriction modification,crispr cas,prokaryotic argonaute,abortive infection
GreenS – Green public procurement supporters for innovative and sustainable institutional change (GreenS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Spain,Spain,Italy,Germany,Italy,Cyprus,Bulgaria,Slovenia,Slovenia,Bulgaria,Sweden,Latvia
Call: Public procurement of innovative sustainable energy solutions (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 1489540.33
EU funding (EUR): 1489540.33
Participants: 14
Project status: CLOSED

The main goal is to strengthen capacity of public authorities to successfully apply GPP with priority, enhancing their ability and capacity to save energy, reduce CO2 emissions and costs by applying innovative solutions on GPP. By the establishment of “supporting permanent structures”, called G.PP.S. – Green Public Procurement Supporters (Supporting Units) within the participating Energy Agencies, the project implementation provides long-term support and technical assistance on GPP to the public authorities, and multi-level cooperation among different actors at national, regional and local level on GPP. The project objectives are to address the obstacles to the uptake of GPP that have been identified by the partners in their own country (context analysis) and which come from the WP2 – Institutional needs on GPP and Good and bad practices analysis in each participating country. The implementation of pilot projects, by aiming to intensively consult public administrations in the implementation of pilot green procurement process, have the scope to test on the field that are the most efficient and effective actions to provide GPP implementation and up-take. More concretely, the project aims at achieving the specific objectives, by implementing the following actions: • analysing in each participating country the existing bad and good practices on GPP; • analyzing the SEAPs in each participant country. By the SEAPs’ analysis, the consortium will find where local authorities need support for “Green” products and services (energy related); • establishing so-called G.PP.S. in Energy Agencies in 7 EU participating countries. • giving support on GPP instruments and tools • setting up and supporting sustainable training programmes (including how to finance them) and finding long-term solutions by the institutionalisation of GPP training • testing GPP application and innovation • at least 21 PA will be invited to experiment the technical support by the G.PP.S

Keywords: energy agencies,institutional bodies,support units,innovation solutions on gpp
Adaptive Optics for Quantum Communication (ADOQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-09-07
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Securing exchanges of information on a global scale represents a major challenge in our society today. The emerging field of quantum communication relies on the fundamental laws of physics to offer unconditional security. In this respect, encoding information on spatial properties of photons has recently demonstrated a strong potential for increasing security level and data rates of quantum communications. However, disturbances in the distribution of quantum states in free-space (i.e. atmospheric turbulence) are critical challenges that must be overcome to advance beyond laboratory proof-of-principle demonstrations and implement long-distance communications. The goal of this work is to enhance information capacity and enlarge distances of free-space quantum communications by monitoring optical disturbances using adaptive optics. This ambitious goal will be achieved by combining the powerful techniques of the emerging field of quantum light shaping, with the speed of adaptive optics systems and the extreme sensitivity and high temporal resolution of quantum imaging sensors. Specifically, the proposal is based on our novel insight that wavefront correction performed in the classical domain (i.e. using an intense classical light beam) can be transferred to the quantum domain to prevent degradation of quantum states that carry the information.

Keywords: adaptive optics,quantum communication,quantum information,high dimensional quantum key distribution,wavefront shaping,disordered media,optical aberrations,atmospheric turbulences
Fibres in Ancient European Textiles (FIBRANET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

FIBRANET will shed light to questions on the types of fibres used in ancient Europe, provide data to enhance future identification studies, and open up new paths of possibilities when considering probable answers to fibre identification inquiries. It will bring together conservation, science and archaeology to provide a new interdisciplinary methodology and new interdisciplinary evidence. My objectives are: 1 To produce new knowledge and get training. 2 To answer the research questions: What types of fibres were used in ancient Europe? How should fibre samples be collected? How can fibre deterioration be assimilated? What is the most appropriate analytical methodology? Test the hypotheses: Even similar fibres can be differentiated; Different deterioration mechanisms affect different fibres in specific ways. 3 To ensure sustainability of my results. In collaboration with CTR philologists I will identify fibre references in ancient texts. I will compile data and samples from plants and animals, measure and document fibre properties and morphology as extracted and processed. A unique feature is that the fibres will be treated to assimilate deterioration. Most important, I will create Fibranet, an online database, to make my results available to conservators, archaeologists, biologists, forensic scientists, artists, craftspeople. Fibre identification is the key element in ancient textile studies but surprisingly enough, insufficiently explored. Prolific work has been done in the past, often with inconclusive results mainly due to the rarity and poor condition of the finds, and the immense variety of fibres used locally since antiquity. As a textile conservator trained to detect and understand fibre degradation, I can carry out this highly specialised task. For the analyses, I will use optical and Scanning Electron microscopies, so that my methodology is reproducible. The demand to address these issues is compelling and my project is the only means to achieve that.

Keywords: ancient textile fibres,plants,conservation,fibre identification,archaeometry
Innovative Methods for wave energy Pathways Acceleration through novel Criteria and Test rigs (IMPACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Norway,Portugal
Call: New test rig devices for accelerating ocean energy technology development (H2020-LC-SC3-2020-RES-RIA, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 3342937.5
EU funding (EUR): 3342937.5
Participants: 5
Project status: SIGNED

IMPACT is a collaborative research and innovation project which aims to develop and demonstrate a next-generation testing approach for Wave Energy Converters (WECs). The proposed 250kW Dual Hardware-In-the-Loop (DHIL) testing platform is based on a technology which expands the capabilities of the already established Hardware-In-the-Loop technique. The DHIL platform combines together: • one rig for testing the entire drivetrain either linear or rotary, from input mechanical to grid compliant power; • one rig for testing structural components and mooring lines, either in dry or wet environment. The DHIL platform is therefore expected to test subsystems impacting on the 75% of the Levelized Cost Of Electricity (LCOE) of a wave energy converter. The novel methodologies proposed by the IMPACT project reduce the test duration by 50% with respect to a typical endurance test and focus on key aspects such as reliability, performance and survivability. Clear quantitative, test-derived metrics will be produced to characterize these aspects, including also techno-economic and environmental impact assessment of WECs. A test campaign involving subsystems of different device types will be undertaken during the IMPACT project to demonstrate the DHIL testing platform capabilities. A Technical Advisory Board made up of WEC developers will directly benefit of the campaign results and will provide external guidance for making the DHIL testing platform a suitable product for the international market. At the end of the project a novel platform for all the wave energy converter types will be delivered, contributing to a drastic acceleration in their progress through laboratory tests and leading to a rapid advancement from TRL 3 to TRL 5. A publicly released deliverable will describe the project results regarding the novel DHIL testing approach, methodologies and metrics to facilitate their implementation in future testing practices for the development of wave energy technologies.
Green Industrial Policy in the Age of Rare Metals: A Transregional Comparison of Growth Strategies in Rare Earth Mining (GRIP-ARM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Our new global political economy is increasingly defined by ‘critical raw materials’ – of which rare earths elements (or ‘rare earths’) are the most significant. The proposed study examines the globalized supply and demand for rare earths – from mining, processing, manufacturing, use and recycling – to have a closer scrutiny of mining both as a strategy for industrialization and as an integral part of contemporary efforts towards a sustainable supply of raw materials. GRIP-ARM interrogates the dynamics in rare earth mining that might lend this particular resource a tool for economic development. The project seeks to answer the following questions: (1) How do state capacity, business power and organizational structure of domestic markets shape the design of industrial policies in resource-rich countries? (2) What explains the success of some countries in generating linkages between resource extraction and manufacturing, and what accounts for their failure? (3) How effective are the responses of importing countries and their manufacturing industries in securing a stable supply while reducing the socio-environmental costs of extraction? The proposed research is one of the first systematic, comparative study on rare earths mining and economic development, which brings political science perspectives in conversation with natural resource geography and international political economy.

Keywords: development studies,political economy
First chemical free, sustainable & scalable disinfection system for intense agriculture in greenhouse facilities (SPARC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global population recently surpassed 7 billion and is projected to reach 9.6 billion by 2050. As a result, food production will need to increase by 70% to ensure a sufficient supply of food. Hence, growing vegetables, fruits, and other products in greenhouses has become a well-established commercial practice since there are advantages in terms of sustainability, reliability, production rate, money and space for many companies in the agriculture sector. However, greenhouses are also home to many kinds of pests, insects and plant diseases that reduce the quality and yield of crops and result in lower production and reduced profits. Hence, in order to protect plants and attain maximum yield and profits, large amounts of hazardous pesticides must be sprayed on crops in the greenhouse to kill these pathogens and pests, and this not only damages the plants but also has a large carbon footprint. To solve this problem, TechMist developed the SPARC™, a ground-breaking chemical free and 100% environmental neutral disinfection system for removal of pests, insects and plant diseases from greenhouses facilities. SPARC™ is a patented non-toxic and highly reactive gas-based system, which combines 5 particles that are naturally present in the environment and supercharging their ability to neutralize pests. It is completed with wireless sensing devices that are used to continuously monitor the greenhouse environment and track the effectiveness of SPARC™ gas and ensure maximum reliability. By providing a system that completely neutralize the greenhouse environment for pathogens on a maximum of two treatment per year, they expect to reduce the operating costs to growers, offering up to 67% net savings when compared to conventional and chemical-based pesticides. The implementation of the innovation project will place TechMist in a strong position to exploit a market potential over three years exceeding €14 million and creating at least 30 new jobs.

Keywords: greenhouses,disinfection system,food safety,food quality,chemical free,zero footprint,sustainable agriculture
Support to the Vice-Presidents of the ERC Scientific Council 2016 (ERCSC-VPRES-SUP2016)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Spain
Call: European Research Council (H2020-Adhoc-2014-20, 2015)
Start date: 2016-01-01
End date: 2016-12-31
Duration (months): 12.0
Total project cost (EUR): 282874.96
EU funding (EUR): 282874.96
Participants: 1
Project status: CLOSED

Support to the Vice-Presidents of the ERC Scientific Council 2016

Keywords: support erc vice presidents scientifc council 2016
Production and characterization of endocrine cells derived from human pancreas organoids for the cell-based therapy of type 1 diabetes (LSFM4LIFE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Germany,Switzerland,France,Netherlands,United Kingdom
Call: Tools and technologies for advanced therapies (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 5120275.0
EU funding (EUR): 4666400.0
Participants: 8
Project status: CLOSED

Self-renew and multilineage potential characterize stem cells. We have recently described that pancreas progenitor cells extracted from adult donors can be expanded long-term in vitro into 3D structures, which we have termed organoids. Pancreas organoids reproduce in vitro all the features of pancreas ductal epithelia, and have a limitless expansion potential. Thus, pancreas organoids promise to boost cell therapy of type 1 diabetes. We have recently observed that progenitor cells organoids preserve their genetic stability over a long time in culture. That represents an advantage, when compared to iPS or hES derived approaches, where genetic instability raises concerns for their future therapeutic applications. While progenitor organoids are promising for the future of cell therapy, bringing stem cell-based therapies to patients requires a reliable characterization (“knowing what the cells do and how they do it”, i.e. a phenotypic and molecular biology characterization), chemically well-defined culture media, and the capacity of mass-production under GLP/GMP conditions. The LSFM4LIFE consortium aims to the mass production of pancreas organoids for the cellular therapy of type 1 diabetes. The goals of the project are: (1) optimize growth and differentiation of human pancreas stem-cell organoids by employing phenotypic and molecular high-throughput screening (2) standardize the growth and differentiation of the organoids under well-defined biochemical conditions, and (3) achieve GLP/GMP-production of the human organoids for preclinical studies and phase I clinical studies. The close collaboration in the consortium between academic researchers and industry, as well as its cross-disciplinary composition, are essential to realize the goals of the project. The work packages of the project will have a technological impact in the form of patents and first market replication.

Keywords: progenitor stem cells,stem cell organoids,type 1 diabetes,cell therapy,regenerative medicine,light sheet based fluorescence microscope,lsfm,high throughput screening,ht lsfm
Cost-effective, Multilingual, Privacy-driven voice-enabled Services (COMPRISE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Latvia,France,France,France,France
Call: A multilingual Next Generation Internet (H2020-ICT-2018-2, 2018)
Start date: 2018-12-01
End date: 2021-11-30
Duration (months): 36.0
Total project cost (EUR): 3201016.25
EU funding (EUR): 3201016.0
Participants: 8
Project status: CLOSED

Besides visual and tactile, the Next Generation Internet will rely more and more on voice interaction. This technology requires huge amounts of speech and language data in every language to reach state-of-the-art performance. The standard today is to store the voices of end users in the cloud and label them manually. This approach raises critical privacy concerns, it limits the number of deployed languages, and it has led to market and data concentration in the hands of big non-European companies such as Google, Facebook, etc. COMPRISE defines a fully private-by-design methodology and tools that will reduce the cost and increase the inclusiveness of voice interaction technology through research advances on privacy-driven data transformations, personalised learning, automatic labelling, and integrated translation. This leads to a holistic easy-to-use software development kit interoperating with a cloud-based resource platform. The sustainability of this new ecosystem will be demonstrated for three sectors with high commercial impact: smart consumer apps, e-commerce, and e-health. COMPRISE will address the mission-oriented challenges of privacy-by-design, inclusiveness, and cost-effectiveness in a sector-agnostic way; allow virtually unlimited collection of real-life non-private quality speech and language data; enable businesses in the Digital Single Market to quickly develop multilingual voice-enabled services in many languages; allow all citizens to transparently access contents and services available in other languages by voice interaction in their own language; result in cost savings for both technology providers and users. COMPRISE will find application in many sectors beyond those demonstrated, e.g., e-government, e-justice, e-learning, tourism, culture, media, etc. It will have a huge societal impact in terms of unprecedented verifiable privacy guarantees, service to speakers of under-resourced languages or accented speakers, and overall user experience.

Keywords: spoken interaction,privacy by design,personalisation,weakly supervised learning,deep learning