Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PREparing for a Long-Term Joint EU-AU Research and Innovation Partnership on Renewable Energy (PRE-LEAP-RE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Italy,Algeria,South Africa,Germany,Belgium,Finland,Greece,France,Netherlands,Netherlands,Kenya,Rwanda,United Kingdom,Senegal,Burkina Faso
Call: Support action in preparation of a Joint Programming activity (H2020-LC-SC3-2018-Joint-Actions-1, 2018)
Start date: 2018-07-01
End date: 2019-10-31
Duration (months): 16.0
Total project cost (EUR): 996762.5
EU funding (EUR): 996762.5
Participants: 17
Project status: CLOSED

Africa is still poor in energy supply even if impressively endowed by energy resources. Facing the global climate change, the continent will become increasingly energy demanding due to its growing population and economy, both claiming access to reliable, clean and affordable energy services. Therefore, Africa cannot lose momentum to exploit the potential of renewable energies (RE) to unleash local development. One effective way to support this transformation is by empowering local research and innovation through co-development relaying on international cooperation. This approach is the pillar of this CSA, which will create the conditions to transform research into effective innovation, tailored to the diverse needs, capacities and aspirations of African societies. By adopting a Theory of Change’ framework, the CSA is specifically focused on three actions: • Elaborating a review of past and current Africa-Europe collaborative initiatives in the field of RE to enable effective synergies with on-going activities, and identify research and capacity needs while avoiding duplication of efforts. • Designing technological and social innovation research pathways in compliance with the Knowledge Triangle, catalysing thus education, research and innovation. While maintaining the core focus on Technology, the pathways will be comprehensive of essential elements for long term sustainability such as business models, capacity building, financial schemes and regulatory frameworks. The Research Agenda will be thus complemented by a Human and Institutional Capacity Building Agenda and by proper organisational and funding principles for an efficient governance of the forthcoming Joint Programme.

Keywords: africa eu cooperation,joint programme,randi,capacity building,reliable,clean and affordable energy
SpaceInvader – Gain value from empty and unused cargo space (SpaceInvader)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Denmark
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-08-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

500 million EURO pallets are used in 4 billion cargo transports every year in Europe. The pallet infrastructure in central to European cargo as transporters can use and leave pallets with minimal transactions costs, as all parties involved use the same standard. This market standard is central to efficiency. The problem While the infrastructure is established and well-functioning, the efficiency is decreasing in recent years resulting in higher CO2 costs and inefficient marginal cost per pallet. The efficiency is decreasing as weight per pallet is decreasing; leaving unused weight & volume potential as most trucks can carry more weight & volume than what is currently loaded. The main issue is the lack of floor space, and that pallets are not easily stacked on top of each other, leaving unused volume in the top space of the truck. Our solution The solution is an extension of the present EURO pallet technology to accommodate the decrease in cargo weight. SpaceInvader ApS has developed a multilayers pallet stacking system, called the SpaceInvader. Combined with existing equipment, the SpaceInvader enable pallets to be stacked in two layers and thereby use the free top space capacity available in 80-90 % of all truck transportations. The potential value of the solution for transportation companies is very high, as the sector makes revenue and compete on very low marginal costs. By being able to fully optimize the load of their trucks, transportation companies become more competitive, and can reduce their carbon footprint by simply having to drive fewer times in order to deliver the same amount of goods. Based on initial input from large test customers (ASKO, SuperGros, Danske Fragtmænd), we have chosen a business model where a set of SpaceInvaders will be rented out for 65 € a month. The expected value for the transportation company is 260 € a month, meaning the cost of renting a set of SpaceInvaders will be covered after just one week of use.

Keywords: transportation,cargo optimization,food industry
Activities on drone integration and demonstration in VLL operations (SAFEDRONE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Israel,Spain,Belgium
Call: Safe integration of drones (H2020-SESAR-2016-2, 2016)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 1455768.75
EU funding (EUR): 1169074.13
Participants: 7
Project status: CLOSED

The scope of the SAFEDRONE project is to acquire practical experience in Very Low Level (VLL) operations where general aviation, state aviation and optionally piloted aircrafts and drones will share the airspace. It is important to highlight that this project will have a clear practical focus which primary activities will be innovation, integration, and especially, demonstrating activities with flight tests. The specific objectives of SAFEDRONE are the following: 1. Demonstrate how to integrate general aviation, state aviation, optionally piloted aircrafts and drones into non-segregated airspace in a multi-aircraft and manned flight environment, in order to explore the feasibility of U-Space vision by 2019. 2. Perform a large number of demonstrations in order to accumulate evidences and experience about the required services and procedures necessary to operate drones in a safe, efficient and secure way within U-Space. 3. Validate proof of concept implementations of a large variety of U-Space services and procedures. 4. Provide evidences to EASA and National Aviation Authorities to reinforce the safe integration of drones under U-Space for the different drone categories. Also, the lessons learnt and the technologies used during the project will be proposed to the different standardization bodies. 5. Coordination with the recently approved SESAR-RPAS projects in order to align the demonstrations with the CONOPS and technological developments of these projects. 6. Increase the awareness of the advances in U-Space within Europe through the dissemination of the obtained results. Finally, SAFEDRONE consortium is formed by 2 private companies (INDRA and UNIFLY), 2 government-owned companies (IAI and ENAIRE), two aeronautical research centres (CATEC and CRIDA) and one university (University of Seville) obtaining a balance among accessing to novel technology, integration and operational experience, and orienting the demonstrations towards real market needs.

Keywords: unmanned aerial systems,drone,u space,vll operations
Supercapacitive Polymer Electrodes for Directing Epithelial Repair (SPEEDER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany,Sweden
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1488750.0
EU funding (EUR): 55000.0
Participants: 2
Project status: SIGNED

In this project we develop a new approach, using the conducting polymer poly (3,4-ethylene dioxythiophene) (PEDOT) to apply electrical fields (EFs) for guidance of cells. EFs are recognised as important guidance cues in the development and life cycle of human tissues. However, better tools are urgently needed to support experiments and applications. By developing supercapacitive PEDOT electrodes, able to support an ionic flow over extended time frames, we here target the most widely studied clinical application for EF stimulation, accelerated wound healing. Our technology facilitates the transfer from petri dish to device by offering an alternative driving process to metals. In addition, we establish a strategy where electrodes can be recharged in situ, by using intermediate periods of current flow in the reverse direction and below the threshold for triggering a biological response. Ionic flow driven by PEDOT electrodes can, in contrast to metals, be reversed with any small ion present in the electrolyte. The project will be driven in several steps: after proving the principle in scratch assays in vitro, we will proceed to three dimensional culture systems. The versatility of our concept will allow more complex wound healing models to be studied including human ex-vivo models. We will employ microfluidics to make high-throughput screening possible, thereby efficiently mapping EF parameters and especially the effects of sub-threshold stimulation. The ultimate goal at the end of the project is to transfer technology in the form of a polymer based wound-dressing for accelerating repair, the SPEEDER. In summary, we present a new concept which greatly facilitates EF stimulation in vitro and shows great promise for clinical use. Studies will better reproduce the biological situation, provide data essential for understanding this important effect, and point the way for how it can best be exploited for future applications.

Keywords: conducting polymers,pedot,electromigration,wound healing,tissue engineering
4-Dimensional printing for adaptive optoelectronic components (xPRINT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy,Italy,Italy
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1993908.0
EU funding (EUR): 1773858.0
Participants: 3
Project status: CLOSED

This project aims at developing four-dimensional printing of new adaptive systems, namely printing of complex, three-dimensional polymer objects embedding functional compounds and able to change or adapt their physical properties responding to environmental stimuli. Additive manufacturing of three-dimensional objects relies on depositing or curing materials in a layer-by-layer fashion, starting from computer assisted design. These technologies have rapidly evolved from laboratory research to commercially available desktop systems, with costs decreasing continuously. Notwithstanding such astonishing progress, the potentialities of three-dimensional printing are still poorly exploited in terms of both materials and process resolution. This project will shed new light on the fundamental aspects of three-dimensional polymerization, thus establishing new process design rules and predictive tools for printing resolution. It will also specifically engineer additive manufacturing for printing materials embedding active compounds, thus leading to real four-dimensional objects, namely structures that have three-dimensional features and time-changing physical properties at the same time. An integrated approach will be pursued to this aim, where modeling and process engineering will be complemented by process monitoring, in order to establish well defined and reproducible methods for four-dimensional printing of photonic structures. The operation of the adaptive components, for optical computing and data storage, will be based on their nonlinear response to optical inputs. Leading to a new and pioneering laboratory on four-dimensional printing technologies, this project will critically consolidate scientific independence.

Keywords: three dimensional printing,adaptive materials,additive manufacturing
Atomic-scale physics of single-photon sources. (APOGEE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 1996848.0
EU funding (EUR): 1996848.0
Participants: 1
Project status: SIGNED

Single-photon sources (SPSs) are systems capable of emitting photons one by one. These sources are of major importance for quantum-information science and applications. SPSs experiments generally rely on the optical excitation of two level systems of atomic-scale dimensions (single-molecules, vacancies in diamond…). Many fundamental questions related to the nature of these sources and the impact of their environment remain to be explored: Can SPSs be addressed with atomic-scale spatial accuracy? How do the nanometer-scale distance or the orientation between two (or more) SPSs affect their emission properties? Does coherence emerge from the proximity between the sources? Do these structures still behave as SPSs or do they lead to the emission of correlated photons? How can we then control the degree of entanglement between the sources? Can we remotely excite the emission of these sources by using molecular chains as charge-carrying wires? Can we couple SPSs embodied in one or two-dimensional arrays? How does mechanical stress or localised plasmons affect the properties of an electrically-driven SPS? Answering these questions requires probing, manipulating and exciting SPSs with an atomic-scale precision. This is beyond what is attainable with an all-optical method. Since they can be confined to atomic-scale pathways we propose to use electrons rather than photons to excite the SPSs. This unconventional approach provides a direct access to the atomic-scale physics of SPSs and is relevant for the implementation of these sources in hybrid devices combining electronic and photonic components. To this end, a scanning probe microscope will be developed that provides simultaneous spatial, chemical, spectral, and temporal resolutions. Single-molecules and defects in monolayer transition metal dichalcogenides are SPSs that will be studied in the project, and which are respectively of interest for fundamental and more applied issues.
Targeting endothelial barriers to combat disease (BreakingBarriers)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-07-01
End date: 2024-06-30
Duration (months): 60.0
Total project cost (EUR): 2499969.0
EU funding (EUR): 2499969.0
Participants: 1
Project status: SIGNED

Tissue homeostasis requires coordinated barrier function in blood and lymphatic vessels. Opening of junctions between endothelial cells (ECs) lining blood vessels leads to tissue fluid accumulation that is drained by lymphatic vessels. A pathological increase in blood vessel permeability or lack or malfunction of lymphatic vessels leads to edema and associated defects in macromolecule and immune cell clearance. Unbalanced barrier function between blood and lymphatic vessels contributes to neurodegeneration, chronic inflammation, and cardiovascular disease. In this proposal, we seek to gain mechanistic understanding into coordination of barrier function between blood and lymphatic vessels, how this process is altered in disease models and how it can be manipulated for therapeutic purposes. We will focus on two critical barriers with diametrically opposing functions, the blood-brain barrier (BBB) and the lymphatic capillary barrier (LCB). ECs of the BBB form very tight junctions that restrict paracellular access to the brain. In contrast, open junctions of the LCB ensure uptake of extravasated fluid, macromolecules and immune cells, as well as lipid in the gut. We have identified novel effectors of BBB and LCB junctions and will determine their role in adult homeostasis and in disease models. Mouse genetic gain and loss of function approaches in combination with histological, ultrastructural, functional and molecular analysis will determine mechanisms underlying formation of tissue specific EC barriers. Deliverables include in vivo validated targets that could be used for i) opening the BBB on demand for drug delivery into the brain, and ii) to lower plasma lipid uptake via interfering with the LCB, with implications for prevention of obesity, cardiovascular disease and inflammation. These pioneering studies promise to open up new opportunities for research and treatment of neurovascular and cardiovascular disease.

Keywords: angiogenesis,lymphangiogenesis
High Sensitivity Matter-Wave Gravitation Sensors (MWGRAV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-15
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

After more than 20 years of fundamental research, atom interferometers have reached sensitivity and accuracy levels competing with or beating inertial sensors based on different technologies. Atom interferometers offer interesting applications in geophysics, inertial sensing, metrology and tests of fundamental physics. Recently, a growing interest of the application of atom interferometry to gravitational wave detection and geophysics has been drawn. These applications beyond the pure scope of atomic physics require the development of more performant atomic inertial sensors, particularly for the use of matter-wave interferometers in gravitational wave detectors, where sensitivity levels far beyond the state of the art must be demonstrated. The proposed project aims at contributing filling this gap by studying new atom and optical interferometry techniques, in order to significantly improve the performances of matter -wave gravitation sensors. The proposed MSC action will significantly impact the design of a new class of matter-wave gravitation sensors, which are under study in several countries in the world. In the excellence metrology environment of SYRTE, the MSC applicant will foster challenging developments in atom interferometers, with a high impact on the communities of atomic physics, geophysics and gravitational wave detection. On this path, the Experienced Researcher will benefit from an original and efficient training by the host group through knowledge transfer, acquisition of new scientific and management skills, enlargement of her professional network and development of her track record.

Keywords: matter wave interferometry,inertial sensors,metrology
Novel Cells for Organ Repair (PROMETHEUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-08-01
End date: 2020-10-31
Duration (months): 63.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

In adult organisms, the natural ability to regenerate tissues damaged by injury or aging resides in multipotent tissue-specific precursors in local microenvironments. The number of these precursors is often either limited or declines sharply with age. Moreover, long-term adverse side effects of cancer treatments affect patients of any age. Such treatments tend to diminish the stem cell and progenitor cell populations. In mammals pluripotency occurs only in the early embryo. Since 2006 it has been possible to turn ordinary somatic cells into pluripotent stem cells by using transcription factors (cellular reprogramming). However, pluripotency bears a risk for tumor formation, and thus conventional reprogramming strategies face the challenge of managing uncontrolled growth when applied to organs and tissues. I propose to replenish the tissue-specific precursor cell pool by directly programming local somatic cell types into relevant precursors. My team has already generated such precursor cell types in vitro but not yet in vivo. To bridge the so far insurmountable gap between current in vitro and future in vivo use, we need innovative strategies. I propose to utilize the emerging field of organoid technology (small cell clusters of self-organized tissue) in a scalable automated system to screen possible factors for converting somatic cells into tissue-resident precursors and evaluate them in vivo. This high-risk, high-gain approach enables the development of a new method for testing reprogramming strategies in 3D tissues. Our work indicates that somatic cells can be programmed to become multipotent somatic precursor cells with an efficiency above 50%. My approach circumvents the generation of a pluripotent state and its inherent tumor forming potential. It provides essential insights into the underlying cellular mechanisms of stem cell and tissue renewal in the natural niches and offers the potential of these somatic precursors to regenerate injured or aged tissues.

Keywords: stem cells,in vivo reprogramming,organoids,high throughput liquid handling,tissue specific somatic stem cells,stem cell renewal,tissue regeneration,automated organoid cultures