Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Descending Control of Motor Circuits in Drosophila (DeCoDr)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Understanding how neural circuits control arm and leg movements is a major challenge in neuroscience with implications for treating movement disorders, designing neural prostheses, and robotics. Limb movements are coordinated by low-level motor circuits in the spinal cord (in vertebrates) or ventral nerve cord (in invertebrates), which receive movement instructions from the brain via a small number of descending neurons (DNs). DNs constitute the critical link between the brain and the body. However, despite their importance, little is known about how specific DNs are recruited depending on the behavioral context, and how low-level motor circuits in the spinal cord or ventral nerve cord translate DN activity into limb movement. I propose leveraging cutting-edge tools to tackle these fundamental questions in the compact nervous system of the fruit fly, Drosophila melanogaster. The fly’s neural circuits for controlling limbs are more tractable and experimentally accessible than those of vertebrates, but still similar in their organization and function. Focussing on DNs that have been implicated in the control of walking speed, I will characterize the activity of DNs during behavior, identify the target neurons of DNs in motor circuits in the ventral nerve cord, and quantify the influence of DNs on these target neurons. By combining intracellular patch-clamp recordings, calcium imaging, and movement tracking in behaving animals with computational modeling and connectomics, the proposed research project will provide unique mechanistic insight into the interactions between the brain and low-level motor circuits that have remained elusive in other animals.

Keywords: motor control,descending neuron,insect,ventral nerve cord,walking,electrophysiology,calcium imaging,motion tracking,connectomics
Eco-Epidemiological Intelligence for early Warning and response to mosquito-borne disease risk in Endemic and Emergence settings (E4Warning)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,United Kingdom,Greece,Germany,Switzerland
Call: Environmental observations solutions contributing to meeting “One Health” challenges (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4082528.75
EU funding (EUR): 4082528.75
Participants: 12
Project status: SIGNED

Mosquito-borne diseases place a heavy burden on society, causing widespread suffering and driving poverty. They are increasing in prevalence, geographical distribution and severity, representing a growing threat worldwide. Hence, there is a need for better disease intelligence, capable of anticipating and identifying eco-epidemiological risks leading to explosive epidemics and emergence in previously unaffected areas. The basis of such intelligence stems from a deep understanding of the factors that drive disease circulation, emergence and spread. This requires insights into the complex interplay between humans, pathogen-carrying mosquitoes, pathogen reservoirs (e.g. birds), and a changing environment. The E4Warning consortium brings together interdisciplinary, innovative, and open science to contribute to the One Health paradigm shift that is required to tackle the spread and transmission of zoonotic deadly pathogens, and harness this shift to nowcast and forecast mosquito-borne disease risk in a constantly changing and globally connected environment. Our work aims to disrupt disease transmission pathways connecting humans, mosquitoes, and birds through innovative eco-epidemiological modelling tools and intelligent digital solutions, co-designed and implemented by public health administrations. Open innovation strategies and big data tools are the cornerstone of the next-level One Health Early Warning Systems required in the face of mounting mosquito-borne disease threats.

Keywords: mosquito borne diseases,one health,citizen science,movement ecology,spatial statistical modelling
Health, Cognition, Family, and Employment among Men (HOMME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Norway
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Men are more likely than women to die prematurely, and a great deal of men’s excess mortality is preventable. Improving men’s health and cognition is not only critical for achieving gender equality, but also for enhancing and extending men’s potential to contribute to their families, the labour market and society as populations grow older. HOMME studies how men’s (changing) family and working lives influence their health and cognition. Men’s family and working lives are changing: Men now lag behind women with regards to tertiary education; female labour participation has increased while male labour participation has slightly decreased. Men are more apt to lose their job due to technological change. Male childlessness has risen dramatically, much more than female childlessness; in many Western countries, one out of four or almost one out of three men are now childless at age 40. Fathers are participating more in childcare, and men have partially lost their role as family “breadwinners”. So far, insufficient research has examined the consequences of these changes on men’s health and cognition. HOMME capitalizes on the richness of Norwegian population register, survey, and genetic data to examine how men’s (rapidly changing) family and working lives are related to their health and cognition across adulthood, as well as across cohorts, periods and between communities. We focus on young adulthood and midlife – the life period most characterized by family transitions and work experiences. We examine cohort and period differences, men’s work-face interface, the male breadwinner model and fathers’ participation in childcare, and disentangle selection and causality. Our data covers genes; parents, (former) spouses and partners; self-reported, clinical, and register measures of health; register data on work participation and occupation; and cognitive trajectories of N=12,000+ men between the late teens to ages 36 to 69 (and potentially beyond, pending funding of the project).

Keywords: demography,family,men
Optimization of fast-ion confinement against edge instabilities for future fusion reactors (FICOP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-12-31
Duration (months): 28.0
Total project cost (EUR): 174233.74
EU funding (EUR): 174233.74
Participants: 1
Project status: CLOSED

The project presented here deals with Fast-Ion Confinement OPtimization (FICOP) in magnetically confined fusion reactors. The goal of the project presented here is the characterization of the effect of edge instabilities on fast-ion confinement and the understanding of the physical mechanisms behind this interaction, as well as to experimentally explore the conditions upon which ion runaway can take place in tokamaks by studying the behaviour of fast-ions in the current ramp-up and ramp-down phases, disruptions, and sawtooth crashes. To fulfill these objectives, novel and cutting-edge data analysis techniques will be developed to be applied to fusion diagnostics, including integrated tomography techniques and deep learning. The results of this project are expected to have a direct impact on the fusion community. The problem of power exhaust in tokamaks mainly focuses on the power dissipation through the divertor plates. Therefore, the limits to tokamak operation are set based on the heat fluxes that the materials in the divertor plates can tolerate. However, an additional constraint might come from the fast-ion heat loads due to edge instabilities that may deposit power not only on the divertor plates but also in the first wall of the main chamber, often in localized areas. The results of this project may help to assess weather fast-ion heat loads to the main chamber first wall due to edge instabilities can pose an additional constraint to the operational regime of a tokamak fusion reactor, or eventually impact its design by the addition of reinforced structures. The experimental results of the project will also be used to benchmark the state-of-the-art codes that the fusion community uses to make projections towards future machines. If successful, the benchmark will strengthen our confidence in our predicting capabilities, while if unsuccessful, the results will motiv

Keywords: magnetically confined fusion devices tokamak plasma diagnostics energetic particles wave particle interaction plasma edge instabilities energetic particle confinement
Explaining Common Envelope Evolution and Dynamics in binary stellar systems (ExCEED)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

A thorough understanding of stellar evolution is key to nearly any branch of astrophysics. The majority of stars evolves in binary or multiple systems and interactions often occur between their components. Such dynamical interaction phases are pivotal for the fate of the system and its constituents, but they elude classical stellar modeling. Common-envelope phases, in which a compact companion spirals into the envelope of a giant primary star, are the glaring gaps in our knowledge and pose one of the last unsolved fundamental problems to stellar astrophysics. The ExCEED project breaks new ground by developing a strategy to reach a comprehensive understanding of common-envelope evolution. It combines leading three-dimensional magnetohydrodynamic moving-mesh simulations with innovative models of physical processes to decipher the dynamical interaction between the stellar cores and the envelope material. On this basis, the post-common envelope evolution is explored by consistently linking to classical one-dimensional models. Predictions for astronomical observables are derived and a faithful effective prescription for representing common-envelope phases in binary stellar evolution and population synthesis calculations is constructed. The new understanding of common-envelope evolution provided by the ExCEED project marks a break- through in stellar astrophysics and has implications beyond this field. ExCEED finally settles the long- standing questions of the mechanism of envelope ejection and the orbital separation of the post-common envelope remnant binary system. This allows to understand the formation of the targets of gravitational- wave astronomy that holds promise to solve problems of fundamental physics, the progenitors of Type Ia supernovae, and many other astrophysical events.

Keywords: binary stellar evolution,common envelope phases,numerical simulations,computational fluid dynamics
STORAGE INNOVATIONS FOR GREEN ENERGY SYSTEMS (SINNOGENES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Luxembourg,Belgium,France,Italy,Spain,Greece,Cyprus,Switzerland,Portugal,Germany
Call: Demonstration of innovative forms of storage and their successful operation and integration into innovative energy systems and grid architectures (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 9687547.56
EU funding (EUR): 7964444.0
Participants: 29
Project status: SIGNED

The European Commission’s Long-Term Strategy describes a number of pathways that reach between 80% and 100% decarbonisation levels. In every pathway a high level of direct and indirect electrification is envisaged, supported by a large-scale deployment of RES. The European power system has to address the residual load variability, on all timescales: from frequency response to inter-year flexibility. The main candidate solutions to provide flexibility are networks, demand-response, dispatchable and flexible power generation technologies, and energy storage. The appropriate deployment of innovative energy storage technologies is of primary importance for the clean energy transition. Sustainability and circular economy approach for storage innovations will minimize the environmental footprint and enhance the overarching efforts for achieving the European Green Deal targets. SINNOGENES project aims to develop the Storage INNOvations (SINNO) energy toolkit, a complete framework of methodologies, tools and technologies that will enable the grid integration of innovative storage solutions beyond the state-of-the art, while demonstrating sustainability, technical performance, lifetime, non-dependency on location geographical particularities and cost. It will develop successful energy storage business cases and systems and deploy them in innovative and 'green' energy systems at different scales and timeframes. SINNOGENES will target the effective integration of innovative energy storage systems and value chains at the interface of renewable energies and specific demand sectors, while ensuring the compatibility of systems and standards of distributed energy storage for participation in flexibility markets. Six pilot projects will take place in Portugal, Spain, Germany, Greece and Switzerland while a detailed scalability and replicability analysis will prove the wide impact of SINNOGENES project innovations at pan European level.

Keywords: energy storage,flexibility,batteries,sustainability,digital twin,hydropower storage,flywheels,thermal storage,power to gas storage
'Use It Up, Wear It Out, Make Do or Do Without'. Reuse, Repair and Recycle in Late Medieval Italy (13th-15th centuries) (ReLMI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

My project aims to produce the first social and economic history of cast-offs management and conversion and reuse in late medieval Italy through the analysis of three case-studies, Fabriano, Florence and Bergamo and their hinterland. By examining the circulation of cast-offs in medieval crafts, identifying practices of reuse, repair, recycling and upcycling, as well as by discovering networks of ‘waste’ management, this project seeks to suggest that certain crafts eventually become embedded practices in the urban economy of late medieval Italy. My aim is to demonstrate that in medieval urban society, where raw materials were expensive and profit margins tight, the re-employment of scraps and by-products was an essential part of craft strategy. The goal is to verify that general economic growth and rise of consumption at the end of the Middle Ages stimulated the use of waste and recycling, and therefore, alternative forms of production to those traditionally employing raw materials. Academic research in the fields of archaeology, material culture, and, more recently consumption has rarely used historical data and material findings together, and generally have considered each element of reuse, repair, and recycling in isolation. My project on Italy in the Middle Ages instead examines all three elements of reuse, repair, and recycling by looking at previously unexplored and unpublished documentary evidence combined with data coming from archaeological surveys and GIS web resources. This will assist in the reconstruction of the technological, economic and social processes that turned cast-offs into complex and tradeable commodities. The cycle of waste, the key role of artisans and producers, their guilds, and on the foreground, institutional policies in cast-offs management will be all pieced together.

Keywords: recycle,reuse,conversion,circular economy,paper,metalware,second hand clothing,rags,medieval italy,fabriano,florence,bergamo
Unveiling the molecular basis of chromatinopathies to delineate innovative therapeutic solutions (Chrom_rare)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Spain,France,United Kingdom,Poland,Netherlands,Hungary
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2468752.46
EU funding (EUR): 2357092.8
Participants: 15
Project status: SIGNED

Chromatinopathies (CPs) are a group of rare genetic diseases, which share clinical features as well as causal genetic alterations, leading to the inactivation of chromatin regulators involved in gene expression control and 3D chromatin organization. Within the framework of Chrom_Rare, we will focus on a group of clinically well-defined CPs, including Kabuki Syndrome, Charge Syndrome, Rubinstein-Taybi Syndrome and Cornelia de Lange Syndrome. Although the causative genes for these CPs have been identified, the consequences of their inactivation both at the molecular and functional level, have not been defined. The clinical features of CPs vary widely, suggesting that the impact of the haploinsufficiency of the affected chromatin regulators could depend on the epigenetic state and/or interactions with additional genetic and environmental factors. Hence understanding the genetic and epigenetic determinants of CPs represent an immediate medical need, as this will ultimately facilitate reaching the development of new therapeutic approaches. Our main goal is to set-up an intra-sectoral, cross-disciplinary training programme that would prepare the next generation of researchers equipped with advanced theoretical, technical and computational skills to study fundamental aspects of chromatin biology and their impact on CPs. In parallel, Chrom_Rare will devise new strategies to translate the molecular findings into new diagnostic and therapeutic approaches for patients affected by CPs. To enable understanding the molecular basis of chromatinopathies, we aim at developing multiple disease models recapitulating the main clinical features of CPs (WP1), investigating the genetic, epigenetic and topological determinants of CPs (WP2) and uncovering perturbed regulatory circuitries suitable for therapeutic intervention (WP3). Overall Chrom_rare will address unmet socio-economic, medical and scientific needs, for the understanding and possible treatment for CPs.

Keywords: chromatin biology,3d chromatin structure,kabuki syndrome,charge syndrome,rubinstein taybi syndrome,cornelia de lange syndrome,drug discovery
Unprecedented photolithographic structuring of novel light-sensitive poly(amino acid) materials– a paradigm shift in delivering biocompatible devices (POLINA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland,France,Spain,Germany,Switzerland,Portugal
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3474342.5
EU funding (EUR): 3474342.5
Participants: 8
Project status: SIGNED

Photolitography, which produces geometrical structures through light-induced polymerisation of monomers with high accuracy, precision and spatial resolution, was a key innovation enabler in the drive for high-performance miniature electronics, which had an unprecedented impact on every aspect of our modern life. Geometrically well-defined microstructures could also be a game changer in the medical device industry, especially in the development of implantable devices with better tissue compatibility, as well as in the discovery of new drugs and treatments. Current gold standard materials and biomaterial extrusion processing cannot generate the structural resolution to kick-start this new era. The groundbreaking approach of POLINA is to combine a radically new, light-sensitive poly(amino acid) material platform with established and emerging photolithographic patterning techniques to deliver a revolutionary technology that can be exploited for medical devices and next-generation green electronics. Exploring this uncharted territory will be possible through an ambitious multidisciplinary approach delivering breakthroughs in photopolymerisation of amino acids and their lithographic structuring for novel materials with unique biological properties. The high innovation potential of this technology to overcome current limitations will be demonstrated in three selected examples related to lung diseases, i.e., micropatterned cell surface models, spheroid arrays for lung disease modelling and drug testing as well as tracheal implants. Our intersectoral team of 5 academic groups and 2 SMEs brings together unique scientific expertise in photo and polymer chemistry, biomaterials science, lithographic processing, tissue engineering, clinical expertise and innovation management. Through POLINA we will pave the way to revolutionise bioprinting, for safer, smarter and affordable medical devices and in the long term a new approach in (bio)electronics.

Keywords: amino acids,poly amino acid s,photolithography,nano structures,2d 3d structures,medical devices