Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Safe Navigation (SafeNav)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Cyprus,United Kingdom,Anguilla,Belgium,Croatia,France,Italy,Norway
Call: Safer navigation and tackling containership fires (HORIZON-CL5-2022-D6-01, 2022)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 5762623.75
EU funding (EUR): 4424871.63
Participants: 11
Project status: SIGNED

SafeNav’s ambition is to develop and test a highly innovative digital collision prevention solution that will significantly reduce the probability of collisions, impact damage, grounding, and contribute to safer navigation by a) faster reliable real-time detection of a variety of obstacles (other vessels, fixed installations, submerged/semi-submerged objects, and marine mammals) in the marine environment, using data from state-of-the-art sensors and other relevant sources, and b) effective visual representation of the multi-source data to the navigators for quick COLREG-based decision-making support. To this end, SafeNav unites 10 key partners from the maritime industry and academia, including renowned SMEs, R&D institutes and universities to address the ‘Navigational Accidents’ aspect of the work programme . We will design collision avoidance algorithms built on multi-sensory data input from propriety (LADARTM sensor suite) and off-the-shelf sensors already installed on vessels, extensive statistics of navigational accidents, and other sources (AIS and route exchange services) to create a holistic decision support system (DSS). Processed information from the automatic DSS will feed into SafeNav collision-avoidance algorithms and generate real-time COLREGs-compliant suggestions for the navigator when an obstacle is detected. This reduces pressure on navigators onboard, providing them with efficient decision-making aid and access to visual navigation data on a single graphical user-interface. Sensors will also be used for container tracking, and mathematical models will predict container drift trajectory, transmitting collected data to a SafeNav Navigational Hazard Database available to nearby vessels/stakeholders, facilitating the recovery of lost containers. Moreover, we propose to prevent vessel collisions with cetaceans with optimal-tuned pingers to alert them of an approaching vessels.

Keywords: navigational accidents,sensor fusion,collision avoidance,object detection,situational awareness,marine mammals,decision support system dss,hazard database,ais,root causes,risk modeling
AmbiJet: the world’s first and only highly effective plasma-based solution for Europe’s 16 Million periimplantitis patients urgently needing help to avoid losing their dental implant (AmbiJet)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1984375.0
EU funding (EUR): 1389062.0
Participants: 1
Project status: SIGNED

Regular dental check-ups and treatments not only ensure a beautiful smile, but good general health: a healthy oral cavity strengthens the immune system and acts as a barrier against various heart-, kidney-, or lungs-related diseases and diabetes. There is currently no effective solution to treat the 16.3 mn infected dental implants (EU, 2019). Freiburger Medizintechnik GmbH developed the solution dentists are looking for: a disruptive technology for highly effective infection control to fight periimplantitis. AmbiJet® is the world’s first and only plasma-based technology with the ability to kill bacteria on dental implants in-situ. It disrupts the status-quo of medical technologies by preventing the reinfection of disinfected surfaces and shows maximum effectiveness without side nor adverse effects: pharmacological and chemical substances are no longer required. AmbiJet® reduces inflammation, saves dental implants and helps patients live a healthier life.

Keywords: plasma technology,periimplantitis,infection control,reinfection,dental diseases,dental implant
Unraveling Ribosome Heterogeneity: Implications for Metastasis and Beyond (RiboHetMet)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Protein translation, considered a mere reflection of transcription, emerges as a regulatory hub, shaping proteomes and directing cellular outcomes. This is due to existence of heterogeneous ribosome populations, yielding specialized ribosomes that drive context-dependent translation. While technological advances enable mapping of ribosomal diversity, questions remain as to the prevalence of the phenomenon and the mechanisms by which specialized ribosomes confer specific functions. Studies propose the presence of onco-ribosomes promoting oncogenic translational programs and regulating disease-related functions. Metastasis, the deadly spread of cancer cells to remote organs, is a key process that relies on rewiring of gene expression networks. Accordingly, our work shows that changes in the expression of coding and non-coding genes affect metastatic potential and correlates with patient prognosis. We further show that environmentally-regulated RNA modifications add to ribosomal heterogeneity. Yet, the involvement of specialized ribosomes in metastasis development is mostly unknown. Here, I propose to map ribosomal heterogeneity in metastatic cancers and decipher the 'ribosomal code' empowering specialized ribosomes to promote oncogenic translational programs and drive metastasis. Using cell lines, animal models and patient-derived samples, we will chart metastatic patterns of rRNA and ribosomal proteins (RPs), as well as of snoRNAs and rRNA modifications they guide. Employing in vivo and in vitro assays, we will uncover individual RPs and snoRNAs influencing ribosomal functions and metastasis formation and investigate their mechanisms of action. These genes and their metastatic patterns along with metastasis-specific rRNA compositions may serve as cancer biomarkers and targets for therapy. This research will advance our understanding of molecular mechanisms underlying ribosome heterogeneity and elucidate involvement of specialized ribosomes in cancer progression.

Keywords: epitranscriptomics ribosomes ribosome heterogeneity pseudouridylation 2 o methylation n4 acetylcitidine snorna rna modification cancer metastasis
Visualizing splicing dynamics in human cells by cryo-ET (SpliceTomo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

The spliceosome is a dynamic, multicomponent macromolecular complex essential for the precise removal of introns from pre-mRNA. While extensive genetical, biochemical, and structural studies have provided insights into the splicing cycle, the structural dynamics and distribution of spliceosomes within human cells remain only partially understood. In this project, I aim to study the in situ structures of the spliceosome by cryo-electron tomography (cryo-ET) and sub-tomogram averaging, alongside other advanced techniques, to elucidate the dynamic assembly and spatiotemporal distribution of spliceosome, as well as its crosstalks with other nuclear machinery. This research aims to visualize macromolecular complexes in their native environments at near-atomic resolution in the nucleus, providing new insights into the mechanisms of pre-mRNA splicing in human cells.

Keywords: spliceosome cryo electron tomography in situ structural analysis dynamic assembly
Flashback and Thermoacoustic Instabilities in Hydrogen/Ammonia Flames (FLAMINGO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 251578.56
EU funding (EUR): 251578.56
Participants: 1
Project status: SIGNED

Carbon-free fuels, such as hydrogen (H2) and ammonia (NH3) can be produced from renewable energy, holding vast potential to develop carbon-free combustion technology and ensure a secure energy supply. Significant differences in the characteristics of the two fuels compared with traditional hydrocarbons present numerous challenges for their application, including issues that hinder the safe and flexible operation of power plants which use gas turbines. However, these challenges can be mitigated through fuel blending. The present proposal will focus on safety related issues, i.e., flashback (FB) and thermoacoustic instability, of aerodynamically stabilized H2/NH3 flames in a novel fully optically-accessible model trapped vortex stabilized combustor. The proposal will address three scientific questions: i) Can the important physical mechanisms underlying FB and thermoacoustic instability be better understood, and can quantitatively predictive FB models be developed? ii) Can the interaction between FB and thermoacoustic instability, which are important in gas turbines operating with hydrogen blends, be characterized, and predictive FB models extended to account additionally for the presence of inlet flow oscillations? iii) Can advanced diagnostics that enable time-resolved three-dimensional (3D+t) measurements be applied to closely confined flames in order to fully understand these inherently unsteady 3D processes? Multidisciplinary knowledge, including combustion science, acoustics, fluid dynamics, optical diagnostics, computational tomography, and signal processing will be employed to address these three questions. After addressing these, we will better understand how flashback occurs, aiding the development of H2/NH3 co-firing technology. Ultimately, this will allow us to develop the next generation of reliable and fuel flexible gas turbines, contributing to Europe’s leading position in the global energy transition.

Keywords: h2 nh3 flames,thermoacoustics,flashback,predictive flashback models,3d tomographic methods
ulTRafast hOlograPHic FTIR microscopY (TROPHY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Spain,United Kingdom,Germany,Switzerland
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 1904544.25
EU funding (EUR): 1904544.25
Participants: 7
Project status: SIGNED

Many human pathologies such as cancer are due to complex biochemical alterations that start at a sub-cellular level and lead to progressive changes that result in a heterogeneous tumor composition. The polyclonality of tumor cells hampers the diagnosis and the therapy giving rise to tumor clones that lead to therapy resistance and promote metastases. An accurate diagnosis of tumor biopsies to identify these particular cell clones is crucial to provide targeted therapy tailored to the tumor characteristics, to improve the patient outcomes and increase survival rates. For this vision to come true, we introduce ulTRafast hOlograPHic FT-IR microscopY (TROPHY) as a paradigm shift in vibrational microscopy, blending elements of photo-thermal infrared (PT-IR), Fourier transform (FT)-IR, and Digital Holography Microscopy (DHM). TROPHY brings these techniques to the unprecedented ultrafast timescale, where the refractive index change induced by coherent IR vibrations is probed at its peak value before thermal relaxation. TROPHY borrows from PT-IR the combination of IR vibrational excitation with visible probing for high spatial resolution, from FT-IR the use of time-domain interferometry to obtain a high spectral resolution from broadband excitation, from DHM highly sensitive and quantitative detection of the refractive index (phase) change. Combined with artificial intelligence algorithms, this technology will enable quantitative concentration imaging of molecular biomarkers with high spatial resolution, high chemical selectivity and high speed, with a transformative impact on medical research and clinics. In oncology, it will be applied to intraoperative diagnosis of tumor biopsies, providing tumor grading, staging and subtyping, and supporting complete tumor resection. It will also allow to determine the best therapeutic approach tailored to the patient and identify resistant tumor clones under targeted therapy, paving the way for precision medicine in cancer.

Keywords: immune oncology microscopy oncosurgery nonlinear optics ultrafast spectroscopy digital holography vibrational spectroscopy
Ultra-Efficient Highly-Integrated 1200V Powertrains for Electric Vehicles Enabling Next-Generation Charging Speeds and Compatibility Across Charger Generations Hop-On (GEN1200 Hop-On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Belgium,Hungary
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 20.0
Total project cost (EUR): 567150.0
EU funding (EUR): 567150.0
Participants: 2
Project status: CLOSED

GEN1200 Hop-On targets the GEN1200 project ("Ultra-Efficient Highly-Integrated 1200V Powertrains for Electric Vehicles Enabling Next-Gen Charging Speeds and Compatibility Across Charger Generations") funded under Horizon Europe Call HORIZON-CL5-2024-D5-01-02: Integration and testing of next generation post-800V electric powertrains (2ZERO Partnership). The GEN1200 Hop-on project aims to integrate RHIVA into GEN1200 to develop a modular, scalable 1200V 3-level SiC inverter, with the objective of improving the driving efficiency of electric vehicles. This will be achieved through a modular power stage architecture by adding discrete power switch dies in parallel to both the vertical and horizontal power switches in 3-level inverters, enabling configurations of up to 600 Arms. The mutual benefits of the main GEN1200 and Hop-on activities are twofold: (i) a comprehensive benchmark, including validation on both 2-level and different 3-level inverter architectures and (ii) enhance modularity and scalability of the traction inverter to other vehicle segments through the use of parallel discrete power switch dies.

Keywords: electric powertrain,power electronics,traction inverter,mechanical integration,thermal integration,e axle,backwards compatibility,fast charging,digital twins,optimal control,battery pack
Miniaturized plasma emission spectroscopy-based breath analysis for unobtrusive at-home monitoring and prediction of COPD exacerbations (BREATH-SENSE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands,Norway,United Kingdom,Portugal
Call: EIC Pathfinder Challenge: Towards the Healthcare Continuum: technologies to support a radical shift from episodic to continuous healthcare (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-11-01
End date: 2027-04-30
Duration (months): 42.0
Total project cost (EUR): 3505325.0
EU funding (EUR): 3505325.0
Participants: 5
Project status: SIGNED

Patients suffering from Chronic Obstructive Pulmonary disease (COPD) suffer from persistent airway obstruction causing shortness of breath and extreme fatigue. Patients are repeatedly hospitalized due to acute flare-ups known as exacerbations, which are largely responsible for the morbidity and mortality associated with COPD. Exacerbations are diagnosed based on symptoms only and diagnosis is often too late. There is an urgent need for a reliable technology for unobtrusive and continuous at-home monitoring of COPD patients to enable timely exacerbation prediction and treatment. The Breath-Sense consortium aims to develop the first-ever hand-held breathalyzer for non-invasive detection of breath biomarkers. RespiQ has developed a breakthrough plasma emission spectroscopy-based breath analysis technology, and will collaborate with sensor development expert SINTEF, user-experience and co-creation expert NeLL and clinical COPD specialist KCL. The consortium will combine innovative technological advancements with human-centric user-experience research to develop and validate a transformative clinical workflow for at-home monitoring of COPD patients. With this digital biomarker-based monitoring solution, patients and clinicians will benefit from reliable and timely prediction of exacerbations, leading to early treatment intervention and preventing up to 95% hospitalizations. The Breath-Sense workflow will deliver a paradigm shift in COPD management, from symptom-based delayed diagnosis towards preventative at-home monitoring prior to symptom worsening. Ultimately, the breathalyzer technology is a platform technology that can be applicable for a wide range of respiratory and gastrointestinal diseases that could also be monitored better continuously at home such as asthma, lung cancer, and IBS, since novel biomarkers can be incorporated for different disease indications. As such, the Breath-Sense technology has the potential to improve the health of millions of people.

Keywords: copd,exacerbations,remote patient monitoring,breath analysis,medical device,volatile organic compounds
Integrating Quality Monitoring into 3D Bioprinting via Light Sheet Microscopy (visionPRINT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

A critical bottleneck in bioprinting hardware is the lack of integrated quality monitoring features for characterising print accuracy and cellular composition during fabrication. This limitation makes it challenging to develop reproducible and standardised bioprinting protocols, which are essential for GMP-compliant production. The lack of integrated quality monitoring also leads to a reliance on destructive, post-printing analysis methods that are incompatible with clinical translation. To address this problem, visionPRINT will develop a 3D bioprinting platform with an optical imaging system and complementary use of Light Sheet Fluorescence Microscopy (LSFM). Unlike current bioprinting hardware systems, visionPRINT will provide volumetric quality assessment of bioprinted constructs. visionPRINT will be the first bioprinting system to offer this level of integrated quality control, and this technological differentiation will help facilitate market adoption as the industry progresses toward standardised protocols and clinical applications. visionPRINT’s integrated data-driven quality monitoring features will transform bioprinting workflows across research, development, and clinical applications. Comprehensive volumetric data logging capturing both construct shape and cell composition will help end users enhance the accuracy and reproducibility of their bioprinting protocols. Furthermore, the technology will make it easier for end-users to standardise protocols and demonstrate GMP-compliant production for regulatory approval. Ultimately, visionPRINT will accelerate the development of safe and functional bioprinted tissues for clinical applications, benefiting patients worldwide.
Internal Fortress: Regulating European Freedom of Movement within the Nation-State, 1950-1980 (InternalFortress)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1426851.0
EU funding (EUR): 1426851.0
Participants: 1
Project status: SIGNED

Against the prevailing view that freedom of movement lowered internal barriers to movement while raising walls against outsiders to create a ‘fortress Europe,’ this project investigates how the introduction of freedom of movement may have strengthened national political authority over European migration within the member states of the European Economic Community (EEC). InternalFortress suggests that as governments gradually lifted entry restrictions across the EEC, they also built out new internal administrative machinery to insert ‘Community migrants’ into key areas of social and economic life, placing migrants from outside the bloc at a disadvantage within local communities. The project explores this hypothesis in three key areas: social security, skill development, and union participation. The PI will lead a team of two PhD researchers and one postdoc to deploy a methodologically innovative multi-layered research program that analyses the interplay between national, European, and international institutions, as well as the private NGO networks that flowed between those formal frameworks. In contrast to previous histories of freedom of movement, which explain policy outcomes leading up to today’s regime of European citizenship, InternalFortress makes an important interpretive innovation by focusing squarely on the early process of transition from the 1950s to the 1970s. The project will investigate how the improvised nature of early integration created gaps and tensions that were consolidated in the 1970s as national and regional migration policies settled into more rigid patterns. InternalFortress suggests that policies behind the border matter as much as policies at the border for understanding the acrimonious debates around European migration that continue through the present.

Keywords: european integration,multi layered governance