Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multidimensional CRISPR/Cas mediated engineering of plant breeding (CRISBREED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 2499981.27
EU funding (EUR): 2499981.0
Participants: 1
Project status: CLOSED

The implementation of CRISPR/Cas technology has already revolutionised biology and biotechnology. However, for plant breeding its full potential has hardly been applied. The gene pool of a plant species carries a tremendous amount of information regarding how to survive best under various biotic and abiotic stresses. Although countless wild varieties of crops have been safeguarded in gene banks worldwide, much of their genetic information cannot be used in agriculture. Often, adverse and/or favourite traits are linked due to the fact that respective genes are located within close proximity, on the same chromosome. Breeding aims not only to break linkages between such traits but also to tightly fix favourable linkages. In cereals, half of the genome cannot be accessed by classical breeding. The aim of this proposal is to develop techniques based on CRISPR/Cas technology, to engineer plant breeding on the molecular level. With the use of the Cas9 nuclease of S. pyogenes and multiple sgRNAs, it became possible to induce several genomic changes at the same time. The aim of this proposal is to perform genome engineering on a multidimensional level by not only inducing multiple DNA lesions (single and double stranded breaks) but also by applying different Cas9 orthologues to simultaneously target DNA recombination factors directly to the sites of action, or indirectly by influencing their expression. Thus, site-specific initiation of recombination should be coupled with pathway choice, resulting in novel approaches for breaking or fixing linkages. Techniques for genome restructuring, like inversions and translocations, should be established as well as efficient induction of somatic and meiotic crossovers. Therefore, the basis should be laid for combining the best available traits of a species, resulting in transgene free crop plants for a sustainable agriculture. Furthermore, the Cas9-controlled transfer of chromosomal segments between species will also be addressed.
Novel microfiltration technology for emissions reduction (SSL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Smart Separations Ltd has developed a revolutionary filtration system that can be tailored to suit many different applications in the underdeveloped yet global €78 billion separation/filtration industry. This device will provide a more controlled, versatile, and low‐cost solution for several industries including blood donations, stem cell R&D, air filtration, and even food and drink processing. We have initially targeted the blood/stem cell and are now focusing on the air purification market, all of which have highly inadequate technologies, where we can make the greatest impact. With this project, we plan to bring the greatest impact by reducing the footprint of industrial gas emissions and thus improving quality of life, a mission that is at the forefront of our company. Emission of micro-particulates, such as PM2.5 and PM10, have been deemed a grave hazard to our health, which our technology has the potential to help tackle. With this funding, we intend to expand the already successful cellular and biological-based technology to air emissions by establishing a clear path to commercialisation through testing the new filtration system on air emissions and conducting market and IP research. We plan to gather market intelligence, develop the go-to-market strategy and business plan, and conduct a partner and IP search, with the aim to test feasibility of the new product. The world market for industrial scrubber, absorber, adsorber and biofilter systems reached £4.3bn in 2015. Incineration is the largest single market, which we plan to tackle first. Our technology has the potential to disrupt and expand the market potential through retrofitting and by simplifying and/or reducing implementation costs.

Keywords: ceramic filters,air purification,industrial emissions reduction,microfiltration,micro particulates,pm2 5,pm10
What causes therapy-related malignancies in childhood cancer survivors? Dissecting the etiology of second cancers (SecondCANCERinKIDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Therapy-related malignancies are a major cause of long-term mortality among childhood cancer survivors. However, it is unclear how exposure to chemo- and/or radiotherapy early in life induces carcinogenesis. My aim is to determine the mechanisms and rate-limiting steps underlying the genesis of second malignancies in childhood cancer survivors. For this, we will focus on studying the etiology of therapy-related myeloid malignancies (t-MNs). I have pioneered methods to characterize mutation accumulation in single stem cells and study clonal lineages in the human hematopoietic system. My lab is embedded in Europe’s largest childhood cancer center, providing the opportunity to apply our techniques to unique patient material. In Objective 1, we will dissect the life history of t-MN and study its cellular origin. Our key question is: Was the original t-MN clone already present before chemotherapy exposure, or generated as a consequence thereof? We will address this by tracking back clonal lineages in the hematopoietic tissue of patients using the mutations present in their second cancers. In Objective 2, we will study the mutational consequences of chemotherapy in normal hematopoietic cells of children before and after they received treatment. Our key question is: Is enhanced mutagenesis rate limiting for t-MN development? To address this, we will perform in-depth mutational analyses and in vitro validations. In Objective 3, we will determine phenotypic effects of chemotherapy on population dynamics of blood. Our key question is: how does chemotherapy affect selection dynamics and clonal composition of blood? To address this, we will integrate clonal histories and lineage contributions using somatically acquired mutations. Our unique methodology and anticipated novel insights will not contribute to improved survival of children with cancer, but also to increased fundamental knowledge on the origin of cancer.

Keywords: therapy related malignancies,cancer etiology,hematopoietic stem cells,somatic mutations,phylogenetic tree
Subsea Cooler for Offshore Wind HVDC transformer platforms (COOLWIND)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 3575000.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Offshore wind (OW) is a key technology in reaching the EUs and UNs ambitions for sustainable energy production. One of the remaining challenges in making OW financially, technically and environmentally viable is reduction of operational cost. In OW the electrical power is transmitted to shore with high voltage technology. A major challenge is the heat generation in the transformer platform that must be removed. The current State-of-the-art cooling solution is to pump seawater up to the platform using electrical pumps and pass seawater through heat exchangers to chill the cooling loop connected to the rectifiers. This is power consuming, brings in particles from the seawater which is causing frequent clogging of filters and gives high maintenance cost for the operator. Chlorination of the seawater is environmentally challenging. Future Technology(FT), the Norwegian SME company behind the COOLWIND project solves this by introducing the unique patented subsea cooler FSCC® (Future Subsea Controllable Cooler). Instead of pumping cold seawater to the transformer platform, heated water from the converters is circulated and chilled in a subsea mounted cooler. FT proposes by this SME Instruments project to industrialize the prototype FSCC® from current TRL6 to TRL9, to reduce operating cost for the OW platform operators. Estimates show that up to 3GWh and 1M€/year may be saved. The following benefits are identified compared to conventional systems: No seawater pumps, No filters, No heat exchanger with seawater cooling medium, No expensive salt water piping, No chlorination of seawater/environmental pollution, Less power consumption and Less environmental emission. All international operators show great interest in pursuing this new technology to benefit from the savings and 2 have already signed LOIs with FT. FT is an SME having a strong team of 32 experts with years of experience from offshore energy projects and close cooperation with vital important subcontractors.

Keywords: windpower,offshore wind,hvdc platforms,water cooling systems,power transmission,hvac platforms,subsea cooler
Development of GPER agonists as a novel therapeutic option for pancreatic cancer (MechanoGPER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-09-01
End date: 2021-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is the fourth-leading cause of cancer related mortality and is predicted to be the second leading cause of cancer death by 2030. Widely regarded as a death sentence, the 5-year survival rate is less than 5% and this figure has not changed over the past four decades due to lack of effective therapies. PDAC develops in a fibrotic setting that hampers drug delivery and modulates immune response & tumour growth/dissemination. Pancreatic stellate cells (PSCs) are the main resident cells in the tumour microenvironment and the drivers of fibrosis. We have recently identified two pathways that mechanically reprogram PSCs and the tumour microenvironment to physiological conditions to inhibit fibrosis, cancer cell invasion, and modulate immune response. One of these mechanisms involves the G protein-coupled estrogen receptor (GPER). Modulating GPER mediated mechanosignalling has emerged as a powerful target in PDAC paving the way to implement new therapeutic approaches, which are so urgently needed. Building on our published data, we plan to demonstrate the efficacy of newly-synthesized compounds to target mechanotransduction of cancer and stromal cells as a therapeutic strategy in PDAC. Within the group of stromal cells, we will focus on: (i) PSCs to target fibrosis, and (ii) tumour associated macrophages, which are known to have tumour-promoting properties. Following this, we want to investigate the efficacy of self-assembling peptide hydrogels to deliver these compounds to pancreatic organoids. The first stage of each work package will be focused on the experimental verification of the efficacy of these compounds to target the different PDAC cell types and how these compounds can be more effectively delivered using hydrogels. Following validation of the proof of concept, we plan to take steps to commercialise these compounds.

Keywords: pancreatic cancer therapeutics,mechanotransduction,gper agonists,fibrosis,immune supression,pancreatic stellate cells
Control of Action Diversification by Descending Motor Circuits Control of action diversification by descending motor circuits (Descent)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-06-30
Duration (months): 70.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Movement is the behavioral output of the nervous system. Animals carry out an enormous repertoire of distinct actions, spanning from seemingly simple repetitive tasks like walking to much more complex movements such as forelimb manipulation tasks. An important question is how neuronal circuits are organized and function to choose, maintain, adjust and terminate these many distinct motor behaviors. Recent technological advances in neuroscience have made it possible to begin to unravel the links between the organization of specific neuronal circuit elements in the CNS and the control of movement, a topic that will be central to this research program. While past work proposes that supraspinal centers in the brainstem are instrumental to the control of action diversification, little is known about how brainstem circuits translate movement intention to body control, how competing motor programs are selected, and how behavioral state influences movement control. The goal of this research project is to unravel the circuit blueprint of mouse descending motor pathways at a fine-scale level and to probe the intersection between revealed circuit organization and their behavioral function at many levels. The focus will be on studies on the interactions between brainstem neurons and spinal circuits to determine how initiation, duration, termination and selection of motor programs are implemented through specific neuronal subpopulations. Mapping descending connectivity matrices of motor circuits will serve as entry point and we will make use of state-of-the art intersectional technology including mouse genetics, viral approaches, in vivo neuronal recordings and activity manipulations of specific neuronal populations during behavior. Together, our project will elucidate the circuit organization and function of the descending motor output system and thereby uncover principles of how the nervous system generates diverse actions.

Keywords: motor system,neuronal circuit organization,mouse genetics,virual tracing
Characterising the dynamical properties of size-selected supported metal clusters (ClusterDynamics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-20
End date: 2019-03-19
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The ability of catalysts to facilitate chemical reactions and to make them selective is of immense importance for industrial production processes. A wide range of heterogeneous catalysts consists of supported active nanoparticles that are intrinsically metastable due to their high surface area. In order to fine-tune catalysts for maximum reactivity and selectivity, a key challenge is the fundamental understanding of particle mobility under reaction conditions. Despite decades of research, these cluster dynamics are still far from being well understood at the atomic scale. Project "ClusterDynamics" aims at investigating model catalysts with an unprecedented degree of definition, in particular size-selected metal clusters soft-landed on inert substrates by use of a laser evaportion cluster source. State-of-the art fast scanning tunnelling microscopy (FastSTM) will be used to monitor cluster diffusion and rearrangement on the atomic scale with a time resolution down to some ms. In particular, Pd clusters, which are a very versatile model system thanks to their rich redox chemistry, will be deposited on Moiré films, such as graphene grown on Ru(0001) or Rh(111) or boron nitride grown on Rh(111), and their dynamics monitored in real-time. Initially, thermally induced lateral diffusion as well as cluster-internal fluctuation will be studied in ultra-high vacuum conditions. Subsequently, it will be determined whether the cluster dynamics are influenced by the presence of adsorbate molecules and whether the adsorbate-cluster interaction is dependent on cluster size. Finally, the cluster dynamics will be studied under reaction conditions. In order to expose the clusters to a high pressure environment, a sniffer tube will be installed that can be brought into contact with the sample to introduce a gas environment. The influence of the ambient can thus be investigated by comparing the cluster dynamics before and after exposure to reactive gas atmospheres.
Integrated Communication, Navigation and Surveillance System (PJ14-W2 I-CNSS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Spain,Ireland,Italy,Italy,Germany,Switzerland,Norway,Belgium,Croatia,Hungary,Lithuania,Romania,Slovakia,Sweden,Norway,Belgium,Poland,France,France,France,France,France,Czechia,Czechia,United States,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: PJ.14 W2 Integrated CNSS (H2020-SESAR-2019-1, 2019)
Start date: 2019-12-01
End date: 2023-06-30
Duration (months): 43.0
Total project cost (EUR): 38518714.96
EU funding (EUR): 18467875.99
Participants: 53
Project status: SIGNED

The PJ14-W2 I-CNSS aims to specify and develop the future Technologies coming from the Communication, Navigation and Surveillance domains in order to support and manage the Operational Services, like the 4D Trajectory Management, in the future ATM System. Performance requirements for CNS systems are becoming increasingly complex and demanding and need to be considered as part of an integrated and holistic System of Systems, which includes air and ground CNS solutions considering convergence towards a common infrastructure, and a unified concept of operations, where possible. In parallel, CNS systems and infrastructure for both airborne and ground must take a more business- and performance oriented approach with efficient use of resources delivering the required capability in a cost-effective and spectrum efficient manner. All the activities performed in the PJ14-W2 I-CNSS will be developed at European Level in order to avoid a fragmented approach and to ensure the interoperability as depicted in the ICAO Global Air Navigation Plan (GANP). The CNS technologies support the GANP in terms of: • Airport Operations • Globally Interoperable System Data • Optimum capacity and flexible flights The PJ14-W2 I-CNSS aims to develop and improve solution, not already available, from the technological point of view to support the future ATM global system, according the timeframe addressed by the ATM Master Plan, mainly in: • Surface Data Sharing to let a huge data exchange for an effective and efficient airport operations and awareness • New Data Communications infrastructure to reduce the ATCo Workload avoiding misunderstandings and improve the efficiency • Collaborative Air Traffic Management to support the ATCos, pilots, airport operators to improve the situation awareness • Optimisation of Capacity, Flexible Use of Airspace and Turn-around operations to avoid congestion in ATM domain In the PJ14 all the main stakeholders are involved to ensure that all the operational needs.

Keywords: hyper connected atm,long term alternative position,navigation and timing,ldacs,satcom,gbas,multilink,ads b,atn ips