Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chromatin 3D architecture in Archaea (3DchromArchaea)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1494500.0
EU funding (EUR): 1494500.0
Participants: 1
Project status: SIGNED

This proposal brings together the field of chromatin evolution and state-of-the-art structural biology to advance our understanding of a fundamental question: origin of chromatin structural and regulatory complexity. Eukaryotes and most groups of archaea organize their genomes in the form of histone-based chromatin. Conservation of histones across the tree of life goes beyond protein sequence and histone fold. Tertiary arrangement of histones and DNA geometry in archaeal nucleosomes resemble those in eukaryotes; however, archaea can form special hypernucleosomes and “slinky”-like arrangements. Similarly to eukaryotes, some archaea have multiple histone variants and extended histone tails, although it is unclear whether their structural and regulatory roles are conserved. Eukaryotes inherited histone-based chromatin from archaea, however, the origins of eukaryotic chromatin complexity are enigmatic. Therefore, this proposal will address the 3D organization of chromatin in archaea to advance the understanding of chromatin evolution. We will test the following hypotheses: archaeal chromatin along with hypernucleosomes contains multiple open structures to maintain DNA accessibility and allow polymerase passage; histone variant exchange and histone tails in archaea play an important role in chromatin compaction similarly to eukaryotes. To test our hypotheses, we will synergistically apply state-of-the-art cryo-electron microscopy (cryo-EM) in situ and in vitro to selected archaeal systems. In situ cryo-EM will provide structural information about chromatin in native context, while cryo-EM of in vitro reconstituted chromatin will provide high-resolution structural information. Structural analysis complemented with biochemical, biophysical characterization and nucleosome positioning data will provide insights into 3D chromatin architecture in archaea in the context of eukaryotic chromatin evolution.

Keywords: chromatin,archaea,cryo em,cryo electron tomography,histones,structure,evolution
Experimental constraints on carbon transformation and reactivity of abiotic/ biotic compounds during serpentinization within the lithosphere (ECoCT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: SIGNED

Circulation of seawater through the oceanic lithosphere represents the largest fluid-rock interaction system on Earth. As a volatile part of biological and geological cycles, carbon is profoundly affected by fluid-rock interactions. As gaseous CO2 and CH4, carbon is a greenhouse gas, and in the form of simple carboxylic acids, it is an energy source for subsurface life. However, our knowledge of carbon fluxes and the fate of especially organic carbon in hydrothermal systems remains limited. Detailed datasets of rock-dominated open system experiments and in situ identification of organic compounds are needed to determine the mechanism that controls CO2 fluxes and reactivity in the subsurface and to extend our knowledge of the deep biosphere. Conventional experiments often use closed system reactors, and microbiology studies often depend on bulk rock analyses. These methods only provide a first idea of the reactions occurring in the lithosphere. The project presented here aims to conduct novel open-system experiments to increase our understanding of environmental conditions and processes that control the in situ transformation and reactivity of carbon compounds within hydrothermal systems. Parameters influencing the reactivity will be disentangled by combining state-of-the-art element and microstructural analyses with new powerful 3D visualization methods. First, a better understanding of organic matter flow within the lithosphere is established. Afterward, a conceptual model for C-transformation will be developed by applying experiments in a monitored environment. Finally, the results will highlight the effect of coupled processes occurring at the pore scale on the carbonation rate and efficiency relevant to industrial implementation. ECoCT will allow me to improve my interdisciplinary skills and thinking, increase my professional network and gain experience in outreach and management, thus greatly enhancing my future career opportunities.

Keywords: carbon cycle,fluid rock interaction,serpentinization,oceanic lithosphere,carbonation,open system experiments,deep biosphere
HYSCALE – ECONOMIC GREEN HYDROGEN PRODUCTION AT SCALE VIA A NOVEL, CRITICAL RAW MATERIAL FREE, HIGHLY EFFICIENT AND LOW-CAPEX ADVANCED ALKALINE MEMBRANE WATER ELECTROLYSIS TECHNOLOGY (HYScale)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,Greece,Netherlands,Italy,Belgium,France,Slovenia
Call: Scaling up of cells and stacks for large electrolysers (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 5295799.25
EU funding (EUR): 5295799.25
Participants: 14
Project status: SIGNED

The HYScale project addresses upscaling of an efficient, durable, sustainable and cost-effective advanced alkaline membrane water electrolysis technology capable of producing economic green hydrogen at significantly higher current densities than SoA electrolyzer. The HYScale technology builds on the results from multiple EU-funded projects. In contrast to SoA electrolyzers, it is entirely critical raw material free without the need for fluorinated membranes and ionomers while meeting a significant fraction of the 2024 KPIs already today at the lab scale. Due to many unique material choices and design features, the HYScale water electrolysis technology distinguishes itself further from the SoA by its potential to be upscaled cost-effective and rapidly. The SME and industry-driven project HYScale aims to upscale its electrolyzer technology with a focus on optimizing materials synthesis and components production, especially membranes, ionomers, electrodes, and porous transport layers. Respecting Europe's circular-economy action plan, a large area stack with an active surface area of 400 cm2 and a nominal power of 100kW will be developed capable of handling a high dynamic range of operational capacities with advanced economic and stable stack components. These efforts will ensure durable and efficient operation at high current densities (2 A cm-2 at Ecell 1.85-2 V/cell) at low temperatures (60 °C) with appropriate hydrogen output pressures (15 bar). The project's final goal is to integrate the stack into a functional electrolyzer system with a CAPEX target of 400 €/kW and its validation in an industrially relevant environment at TRL5. This final step will accelerate technology development, close the gap between research and commercialization, significantly shorten the time to market, and pave the way to a more sustainable Europe.

Keywords: hydrogen,electrolysis,anion exchange membrane,stack,stack development,materials development,upscale,renewable energy storage,life cycle assessment,techno economic analysis,system engineering
Federated Data Sharing and Analysis for Social Utility (HARPOCRATES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Finland,France,Spain,United Kingdom,Sweden,Ireland,Serbia,Germany,Italy
Call: Scalable privacy-preserving technologies for cross-border federated computation in Europe involving personal data (HORIZON-CL3-2021-CS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 4015550.0
EU funding (EUR): 4015550.0
Participants: 13
Project status: SIGNED

Availability of large volumes of user data combined with tailored statistical analysis present a unique opportunity for organizations across the spectrum to adapt and finetune their services according to individual needs. Having shown remarkable results in analyzing user data, machine learning models attracted global adulation and are applied in a plethora of applications including medical diagnostics, pattern recognition, and threat intelligence. However, such service improvements and personalization based on user data analysis come at the heavy cost of privacy loss. Furthermore, practice showed that systems that use such models incorporate proxies that are often inexact, biased and often unfair. In HARPOCRATES, we focus on setting the foundations of digitally blind evaluation systems that will, by design, eliminate proxies such as geography, gender, race, and others and eventually have a tangible impact on building fairer, democratic and unbiased societies. To do so, we plan to design several practical cryptographic schemes (Functional Encryption and Hybrid Homomorphic Encryption) for analyzing data in a privacy-preserving way. Besides processing statistical data in a privacy-preserving way, we also aim to enable a richer, more balanced and comprehensive approach where data analytics and cryptography go hand in hand with a shift towards increased privacy. In HARPOCRATES we will first show how to effectively combine cryptography with the principles of differential privacy to secure and privatise databases. Next, we will build privacy-preserving machine learning models able to classify encrypted data by performing high accuracy predictions directly on ciphertexts across federated data spaces. Finally, to demonstrate how these solutions respond to users’ needs, we will implement two real-world cross-border data sharing scenarios related to health data analysis for sleep medicine and threat intelligence for local authorities.

Keywords: threat intelligence functional encryption hybrid homomorphic encryption differential privacy multiparty computation privacy preserving machine learning
Cross-KIC Global Outreach (XKIC SO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: other EIT
Destination: other EIT
Action type: Knowledge and Innovation Communities
Countries involved: Germany,Spain,France,Netherlands,Sweden,Israel,United States,Belgium
Call: EIT Cross-KIC Strategic Outreach (HORIZON-EIT-2023-2025-KIC, 2023)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 6366150.0
EU funding (EUR): 6366150.0
Participants: 13
Project status: SIGNED

The Cross-KIC Global Outreach programme was established in 2018 to narrow the competitive innovation gap between Europe and other leading markets around the world. It connects the EIT’s innovation ecosystem with those of strategic innovation valleys worldwide, securing the EU and EIT’s position on the global innovation map as a leading player. The EIT Global Outreach has developed and implements a unique, efficient and agile method that delivers high-impact activities in strategic outreach locations, executing the EC’s bilateral agreements in line with international priorities to create significant value for the European economy. The Global Outreach forges synergies, provides access, and generates success stories with global innovation leaders. It enables innovations to be launched on the global market, supports startups in attracting investments, facilitates cross-border consortium building and more. To date the Global Outreach cluster consistently exceeds its core KPIs, with 27 innovations launched on the market, and over €84M investments raised by supported startups and scaleups. The Global Outreach is active in the following strategic locations: Hubs: EIT Hub Silicon Valley (established 2018), EIT Hub Israel (established 2019), EIT Hub UK (established 2024) Pilot locations: US East Coast (2022, 2023, 2024), Japan (2023) Canada (2024) The Global Outreach innovation Hubs and the Global Platform, which operates pilot programmes in key locations, have developed specialized expertise in driving global impact. Their organizational knowledge spans open innovation, global market access strategies, cross-border consortium building, and more. The cluster runs a variety of results-driven programmes worldwide, each tailored to the technology development lifecycle—from ideation to global market launch. These include open innovation programmes for corporates, go-to-market programmes that help startups and scaleups enter new markets, lab-to-market education for researchers turning breakthrough technologies into startups, and consortium building for Horizon Europe open calls.

Keywords: global,globalisation,innovation,innovation valleys,startups,stakeholders,internationalisation,strategic outreach,outreach,bridge,connect,synergy
Bridging the Gaps in Evidence, Regulation and Impact of Anticorruption Policies (BRIDGEGAP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Belgium,Italy,Spain,Sweden,Israel,Romania,France,Netherlands,Bulgaria,Germany,Ukraine,United Kingdom,Malta,Estonia,Latvia,Slovakia,Slovenia,Greece,Lithuania,Hungary,Czechia
Call: New approaches for combatting corruption and other undue influences on political decision-making (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5732238.75
EU funding (EUR): 5732238.75
Participants: 30
Project status: SIGNED

BRIDGEGAP is a multidisciplinary research project reuniting former members of the ANTICORRP consortium (Transparency International, ERCAS/SAR, CSD, University of PISA, University of Perugia) who have continued to invest in the development of data commons allowing corruption understanding and monitoring on the basis of objective data (e.g. Integrity Watch, Index for Public Integrity, T-Index, Russian Economic Footprint), with new academic partners who published novel methods to measure money-laundering (Utrecht University) anthropologists and criminologists who pioneered corruption studies in liberal democracies (IFFS), and new IT groups like the Ukrainian organisation YouControl, the first to interconnect data to enable searches of the assets of sanctioned individuals through its algorithm Follow the Money. BRIDGEGAP fills the knowledge gaps regarding both the extent to and the mechanisms by which corruption infiltrates open societies even across borders and it produces measurements of corruption across countries and time by its innovative models, as well as social network maps. It also assesses and offers solutions to the digital transparency gaps, ranging from the tools of transparency, the use and abuse of technology in corruption and anticorruption to the state of it. Finally, it assesses public accountability and anticorruption regulation across EUMS and candidate states to identify regulatory and impact gaps, thus addressing the academia–policy gap in corruption studies. The research will result in academic publications as well as in interactive analytical and research commons like comparative law repositories EU Compass, European Transparency Index, Follow the Money search engines across newly interconnected databases. All its pooled data will be displayed transparently on the website as a Data Hub and will offer end users the same investigation and analytical tools as the project researchers, inviting crowd-sourcing and offering online tutorials.

Keywords: anticorrp,data hub,european transparency index,media capture risk map,eu compass on anticorruption law eucal,europam eu,online courses
First fast and automated (<5 min) AI-based inspection to increase operational safety of large critical infrastructure, e.g., bridges, dams, and oil & gas platforms and refineries (Twinspect)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 3567750.0
EU funding (EUR): 2497425.0
Participants: 1
Project status: SIGNED

The global inspection, repair, and maintenance market (TAM) is valued at €42.2B. Demand is driven by increasing urbanisation. In Europe, most of the infrastructure is now reaching its 50-100 years lifespan as it was built in the 50s and 60s following the Marshall plan. The drone inspection and monitoring market (SAM) is growing rapidly and is currently valued at €11.1B. Drone inspections enable OPEX & CAPEX savings and keep inspectors safe on the ground. This is driving the demand for data management solutions (one bridge inspection generates >30GB of data), and provides a unique opportunity for intelligence service providers, like us, to enter the market with innovative AI-based solutions that simplify and automate infrastructure inspection. Twinspect is the first photogrammetry solution to enable the inspection of photorealistic 3D models of the infrastructure directly, rather than having to inspect and annotate (often multiple times) defects in large (>2k) photo libraries manually.

Keywords: deep learning,computer vision,3d models,digital twin
PHYtomanagement as a sustainable feedstock source of lignocellulosic-based high-value BIo-based products for textile applications (pHYBi)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Spain,Italy,Germany,France,Croatia
Call: Phyto-management; curing soil with industrial crops, utilising contaminated and saline land for industrial crop production (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 4991538.75
EU funding (EUR): 4991538.75
Participants: 13
Project status: SIGNED

pHYBi is a 48-month action that will combine the soil phytoremediation concept with lignocellulosic biomass valorisation in an integrated phytomanagement circular economy approach. The pHYBi concept will focus its efforts across different levels of development (1) test, optimisation and validation of 4 phytomanagement case studies, (2) optimisation of biomass fractionation into lignocellulosic components based on organosolv techniques, and (3) characterisation and application of lignocellulosic fractions to create a well-planned market route for the potential end-applications in the textile industry. Furthermore, the project will develop a Virtual Replication Tool where phytomanagement, valorisation process and end-products will be integrated, resulting in guidelines, recommendations and thresholds for the replication of pHYBi’s case studies along other areas. To finalise the proposal concept, social innovation activities will strongly connect the process with the market and society with the aim to deliver high quality products with high level of acceptance. To achieve its goals, pHYBi brings together a multidisciplinary team integrating experts in plant and soil science (UBFC, UBU, UNIOVI, PHY), chemical engineering and biorefineries (CETIM), computational science (IDE), textile materials and products (NTT), agroindustry (PARTICULA, PHY, DIH-LEAF), and market analysis, knowledge exchange and social innovation (SEZ).

Keywords: phytoremediation bioremediation microorganisms lignocellulose
Smart Grid-Efficient Interactive Buildings (EVELIXIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Greece,Italy,France,Austria,Romania,Denmark,Spain,Finland,Switzerland,Belgium,Ireland,Cyprus
Call: Smart-grid ready and smart-network ready buildings, acting as active utility nodes (Built4People) (HORIZON-CL5-2022-D4-02, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 10320789.09
EU funding (EUR): 8189865.05
Participants: 37
Project status: SIGNED

EVELIXIA brings together 36 high profile organizations from 12 EU countries envisioning to realize Buildings as Active Utility Nodes (BAUNs), rendering the EU Building stock as: a) energy efficient; b) connected, by facilitating a two-way communication between the grid and the occupants, capitalizing on flexible technologies; c) smart, by utilizing analytics supported by sensors and controls to co-optimize efficiency, flexibility, and occupant preferences; and d) flexible, reducing, shifting, or modulating energy use according to occupant needs, while considering utility signals. EVELIXIA structures the advancement of its solutions along five Innovation Pathways: IP1: Building-to-Grid (B2G) Services; IP2: Grid-to-Building (G2B) Services; IP3: Human-to-Building Interfaces & Interactivity; IP 4: Systems Interoperability; and IP5: Innovative HW as Flexibility Enablers, which will be integrated, deployed, and validated at 7 large-scale, real-life pilots (GR, RO, FR, FI, ES, AT, DK). During the EVELIXIA platform deployment and validation, different actors (i.e., DSOs, DNOs, ESCOs, aggregators) from various sectors (electricity, heating/cooling, mobility) will exchange data for providing B2G and G2B services and they will participate in the development of Business Models showcasing the economic viability of the solutions proposed. EVELIXIA puts a large focus on social engagement empowering citizens as not only adopters of solutions, but also, as their co-creators applying methodologies for citizen and consumer engagement and advanced human to building interfaces. Key expected outcomes include: 14 scalable B2G/G2B services demonstrated including DSF (implicit, explicit, shifting, etc.), P2P energy trading, portfolio management (day ahead/intra-day), TSO/DSO/DHO, and system planning services; GHG emissions reduced by 17%, increase of flexibility by up to 25%, increase of self-consumption up to 100%, reduce energy consumption by 13.5%, and increase RE generation by 11%.

Keywords: smart buildings,active utility nodes,building to grid integration solutions,energy storage,res,building to grid interoperability,predictive maintenance,interoperable platform,big data