Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding mechanisms behind reliable future extreme precipitation estimation over Europe (UMBRELLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 128953.92
Participants: 1
Project status: SIGNED

Extreme precipitation events are among the most damaging climate extremes worldwide. Globally, precipitation extremes are expected to intensify as the climate warms, however, Europe stands out as a region with weak confidence in future extreme precipitation changes. Our lack of knowledge is explained by the variety of mechanisms at play, from local to hemispheric scales, and by two persisting limitations: the deep convection not explicitly resolved in climate models and large uncertainties in future regional atmospheric circulation changes. UMBRELLE aims to characterise the evolution of precipitation extremes over the 21st century in Europe and to provide more reliable projected changes by better understanding the physical mechanisms at play. Innovative modelling experiments are proposed to explore how observed extreme precipitation case studies could respond to climate change and what mechanisms control the future changes. To that end, novel data, tools and methods will be exploited through the use of high-spatial convection-permitting regional climate modelling for the realistic simulation of extreme precipitation that will be combined with the emergent ‘storylines’ approach to identify plausible future pathways for regional atmospheric circulation from a large ensemble of state-of-the-art Earth System Models. The original framework offered by UMBRELLE will allow a leap in our understanding of the regional impacts of climate change on extreme precipitation. It directly addresses each of the two current limitations in our knowledge and provides an innovative way to bridge the gap between the fine scale explicit simulation of precipitation and the most comprehensive simulation of the climate system in order to benefit from their respective strengths and latest advances. This project proposes ambitious research that will not only address one of the most pressing issues affecting the global research community but will be of profound societal benefit.

Keywords: climate extremes,extreme events of precipitation,regional atmospheric circulation,convection permitting simulation,global warming
Dark Matter and the Early Universe in the LHC Era (DARKHORIZONS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1947665.0
EU funding (EUR): 1947665.0
Participants: 1
Project status: CLOSED

The discovery of a Higgs like particle in its first science run shows that we are truly in the LHC era and when collisions resume we will learn more about the physics of the TeV scale. There are two main areas at the interface of particle physics and cosmology that the LHC will shed light on - If dark matter is a thermal relic then we naturally expect new particle physics close to this TeV energy range. The LHC will also help us learn about the nature of the electroweak sector and its behaviour during the early Universe. In this proposal we present a body of work which will combine information from the LHC with dark matter experiments and astronomical observations to understand both the nature of dark matter and the role of the Higgs sector in the first moments after the big bang. We will investigate dark matter by developing a new categorisation of interactions between the dark sector and the standard model. This will enable us to perform detailed collider and direct detection phenomenology in a more comprehensive way than current approaches while avoiding the problems which occur when those methods breakdown. Different schemes for mitigating against the upcoming problem of the neutrino floor in direct detection experiments will also be investigated. Many of the keys to understanding the particle nature of dark matter lie in astrophysics, and we will develop new techniques to understand the distribution of dark matter in the Universe, its behaviour and density in distant galaxies and its velocity dispersion in the Solar system, critical to predict event rates in detectors. We will use LHC and CMB data to answer important questions - Can the electroweak phase transition be first order? What is the role of the Higgs field during inflation? Can we use the electroweak sector to infer information about physics at high energy scale or the nature of inflation? The interdisciplinary experience of the PI will ensure the ambitious project is a success.

Keywords: direct detection,indirect detection,inflation,vacuum stability
Biological Water Alarm System (BiWAS) for protection of urban drinking water infrastructure against CBRN threats (BIWAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Sweden,Norway
Call: Critical infrastructure protection topic 7: SME instrument topic: “Protection of Urban soft targets and urban critical infrastructures” (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Safe drinking water is essentially a global concern, thus resulting in a considerably large market for water quality monitoring. Besides, potential terrorists might threaten water infrastructure in European cities, since poisoning the tap water is a low-cost attack that easily generates social panic and economic loss to the society. Due to lack of the ideal early warning tools on water safety, large amount of routine sampling and testing have to be done frequently to fight against possible CBRN threats on urban water supply. This project addresses feasibility study for the technical and economic viability of Biological Water Alarm System (BiWAS): An innovative low-cost early warning device for monitoring of drinking water safety over a broad spectrum of harmful substances, including (1) acute toxicant chemicals, (2) chronic carcinogenic chemicals, and (3) waterborne pathogens. The innovative content of BiWAS lies in the miniaturisation and integration with multidisciplinary knowledge, which makes BiWAS a continuous, automatic and portable device working for long period with only annually or biannually maintenance. The potential customers include public water suppliers, household users, hospitals, hotels, culinary and food industries, etc. An early warning system against CBRN threats in drinking water can be realized without more investment. A feasibility assessment on BiWAS product under Phase 1 includes market investigation, business plan development, risk assessment, intellectual property management and innovation strategy development. In the potential Phase 2, a commercializable prototype of BiWAS will be expected, which can be probably the first low-cost and broad-spectrum early warning device for water safety. With the outcome of Phase 1, it will guide the European companies towards the leading role of the global water quality monitoring techniques, and open a big door to the large market of global water quality monitoring, from Europe to the world.

Keywords: water related critical infrastructure,water quality monitoring,cbrn threats,living cell sensors,broad spectrum detection
Festival of Science European Researchers' Night 2014 - 2015 in Slovakia (ERN14-15SVK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovakia
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-11-30
Duration (months): 19.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 4
Project status: CLOSED

Sovva, n.o. has been organising the festival of science Researchers´night in Slovakia since 2007. The recent festival featured more than 1000 researchers and attended by nearly 177000 visitors. To continue in this succesful effort we have prepared the new concept for ERN 2014-15 with the following lead ideas: Science is Adventure and Experience the Science. The target is to challenge people to face the Science and to discover its beauty with aim to attracting the young generation to study science. The festival will present the most interesting research findings in Slovakia by leading Slovak universities, research institutes of the Slovak Academy of Sciences as well as representatives of innovative companies supporting R&D activities. The science shows will be held in shopping malls, but there will be also a number of side events in museums and observatories as well as discussions, lectures and various competitions. A wide range of activities will cover all country´s territory (Bratislava, Banska Bystrica, Zilina, Kosice, Tatranska Lomnica). All festival venues in the five cities will offer opportunities to spend the day and night visiting the interesting presentations and lectures, test scientific applications, get in touch with the latest research outcomes and to speak with researchers. Thanks to the direct discussions with them people can discover their "human face". Since efforts during the event and also during awareness campaign will focus mostly on examples showing how interesting and important the career of researcher is, we believe the ERN 2014-15 will help us to tackle the still existing stereotypes about researchers and science and encouraging young people to embark on scientific careers. To support the ERN impact, event venues will be linked through live streaming and as a member of Eusea we will use also this platform to provide the virtual and real connections between cities, venues and countries for exchange and collaboration.

Keywords: science,scientists,researchers,science show,science party,students,children,adventure,experience
IMPACT OF BUIDING BLOCK SHAPE ON SELF-ASSEMBLY KINETICS (colloidlego)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Self-assembly is a spontaneous arrangement of building blocks into ordered structures. Shape of the building block is one of the key factors, determining the structure of resulting assembly. During the process of self-assembly, the building blocks move through thermal motion and, once in contact, adjust their mutual positions and orientations to minimize free energy and form ordered structure. Increasing shape anisotropy of the building block gradually hinders its reorientation during the process and increases the energy barriers. I propose to study the impact of increasing anisotropy of building blocks on their ability to overcome kinetic barriers during self-assembly process and reach equilibrium. Systematic experimental study will be performed with two dimensional Brownian dispersions of platelet microparticles. The platelets will have irregular pentagonal shape of such geometry that allows complete filling of the plane (valid solutions of pentagonal tiling problem). The shape anisotropy of the microparticles will be gradually increased (decreasing symmetry and circularity, increasing complexity of ordered pattern) and the effect on self-assembly kinetics will be evaluated. Proposed study is the first, systematically revealing relation between shape anisotropy and self-assembly kinetics. Its results will enable new fundamental insights into self-assembly of complex shapes. Proposed self-assembly experiments require large quantities of microparticles of complex shapes and, simultaneously, not larger than a Brownian limit (~micron). Thus, I propose to develop novel low-cost high-throughput synthetic procedure, utilizing stop-flow lithography for production of Brownian silica particles. The host group participance in the project is vital as it is currently the only laboratory in Europe, working with stop-flow lithography. Furthermore, self-assembly is the main research theme in the host group, thus I can rely on their excellence in both parts of proposed project.

Keywords: self assembly,stop flow litography,pentagonal tiles
Resurrection plants reveal secrets of vegetative desiccation tolerance (RESIST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Israel,South Africa,Germany,Ireland,Bulgaria
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 1062600.0
EU funding (EUR): 1062600.0
Participants: 6
Project status: SIGNED

A major challenge faced by modern agriculture is abiotic stress caused by unfavourable environmental conditions. Global warming is expected to further intensify these problems, including frequency and severity of drought stress, which seriously affect both crop quality and yield. Therefore, timely action is needed to find solutions to mitigate the consequences of water deprivation. A small number of species called resurrection plants, which can tolerate desiccation of their vegetative organs, are a natural resource that can be tapped to solve this problem. They can withstand transition to air-dried state and completely restore physiological activities upon rehydration. In this project, we will study the genomes of several resurrection species and compare them with the genomes of desiccation-sensitive plants to identify molecular mechanisms that are involved in drought tolerance. In addition to the publicly available data of resurrection plants with already sequenced genomes, we will sequence and analyze two more- Haberlea rhodopensis and Xerophyta humilis. Comparative transcriptomics, metabolomics, and lipidomics of resurrection, model, and crop plants subjected to drought will bring further insights about the nature of drought stress tolerance. The research team involves European specialists in resurrection species, drought signaling, plant systems biology and bioinformatics, a partner from Israel experienced in lipidomics, and the leading African university with expertise in resurrection plants and bioinformatics. Next to that, an industrial partner will ensure that the knowledge gained by studying the resurrection and model species is transferred to crops. Moreover, the company will contribute with novel biostimulant based treatment technologies to mitigate stress and achieve optimal yield and net profit. An extensive mobility program will provide staff exchange to maximize research outputs and increase the human capacity of the partners.

Keywords: comparative omics,desiccation tolerance,drought stress,resurrection species,xerophyta humilis,haberlea rhodopensis
Investigating the LRRK2-melanin connection through phosphoproteomics of isogenic melanoma cells (MELANOPARK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

LRRK2 is a multi-domain protein, which uniquely possesses both protein kinase and GTPase catalytic activities. Autosomal dominant mutations of LRRK2 represent one of the principal genetic risk factors for Parkinson’s Disease (PD), which results in preferential loss of neuromelanin containing, dopaminergic neurons from the substantia nigra. The (patho)physiological roles of LRRK2 are currently unclear. However, it has been linked to the regulation of endolysosmal membrane trafficking through complex formation with other PD-related gene-products (Rab7L and Vps35). LRRK2 is also highly expressed in skin pigment cells (melanocytes), which specifically produce melanin within the lysosome-related organelles known as melanosomes, in a process referred to as melanogenesis. Here we propose to examine the substrates and function of LRRK2 in pigmented melanoma cells. We will generate a MNT1 cell panel expressing PD-associated mutations of LRRK2 using CRISPR/Cas9 gene editing and characterise the respective (phospho)proteomes ±LRRK2 inhibitors from total lysates and from melanosome-enriched fractions using quantitative mass spectrometry. Melanosome biogenesis itself will be compared across the panel using electron microscopic procedures established by the experienced researcher as well as other organelle associated parameters (e.g. contacts with mitochondria) and trafficking pathways linked to Vps35 and Rab7L. The aim is to establish LRRK2 substrates or cellular consequences of activity, which may be specific to melanin-containing cells and link these to PD or to the increased incidence of melanoma observed in PD patients.

Keywords: parkinson s disease,lrrk2,melanosomes,proteomics,crispr
Preparedness and Resilience Enforcement for Critical INfrastructure Cascading Cyberphysical Threats and effects with focus on district or regional protection (PRECINCT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Protect and improve the resilience of critical infrastructures, supply chains and tranport modes
Action type: Innovation actions
Countries involved: Ireland,Italy,Italy,Estonia,Uruguay,Austria,Spain,Spain,Germany,Ireland,Belgium,Greece,Greece,Slovenia,Belgium,Belgium,Switzerland,Greece,France,France,France,Luxembourg
Call: Prevention, detection, response and mitigation of combined physical and cyber threats to critical infrastructure in Europe (H2020-SU-INFRA-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 9472739.05
EU funding (EUR): 7996658.38
Participants: 43
Project status: SIGNED

EU Critical Infrastructures (CIs) are increasingly at risk from cyber-physical attacks and natural hazards. Research and emerging solutions focus on the protection of individual CIs, however, the interrelationships between Cis has become more complex for example in smart cities and managing the impacts of cascading effects and enabling rapid recovery is becoming more pertinent and highly challenging. PRECINCT aims to connect private and public CI stakeholders in a geographical area to a common cyber-physical security management approach which will yield a protected territory for citizens and infrastructures, a ‘PRECINCT’ that can be replicated efficiently for a safer Europe and will deliver: 1. A PRECINCT Framework Specification for systematic CIs security and resilience management fulfilling industry requirements. 2. A Cross-Facility collaborative cyber-physical Security and Resilience management Infrastructure enabling CI stakeholder communities to create AI-enabled PRECINCT Ecosystems and enhanced resilience support services. 3. A vulnerability assessment tool that uses Serious Games to identify potential vulnerabilities to cascading effects and to quantify resilience enhancement measures. 4. PRECINCT’s Digital Twins to represent the CIs network topology and metadata profiles, applying closed-loop Machine Learning techniques to detect violations and provide optimised response and mitigation measures and automated forensics. 5. Smart PRECINCT Ecosystems, deployed in four large-scale Living Labs and Transferability Validation Demonstrators, will provide measurement-based evidence of the targeted advantages and will realize Digital Twins corresponding to the CIs located therein, include active participation of emergency services and city administrations with results feeding back to the Digital Twins developments. 6. Sustainability related outputs including Capacity Building, Dissemination, Exploitation, Resilience Strategy, Policy/Standardisation recommendations

Keywords: serious games,digital twins
Endothelial long non-coding RNAs (Angiolnc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 2497398.0
EU funding (EUR): 2497398.0
Participants: 1
Project status: CLOSED

Endothelial cells comprise the inner cellular cover of the vasculature, which delivers metabolites and oxygen to the tissue. Dysfunction of endothelial cells as it occurs during aging or metabolic syndromes can result in atherosclerosis, which can lead to myocardial infarction or stroke, whereas pathological angiogenesis contributes to tumor growth and diabetic retinopathy. Thus, endothelial cells play central roles in pathophysiological processes of many diseases including cardiovascular diseases and cancer. Many studies explored the regulation of endothelial cell functions by growth factors, but the impact of epigenetic mechanisms and particularly the role of novel non-coding RNAs is largely unknown. More than 70 % of the human genome encodes for non-coding RNAs (ncRNAs) and increasing evidence suggests that a significant portion of these ncRNAs are functionally active as RNA molecules. Angiolnc aims to explore the function of long ncRNAs (lncRNAs) and particular circular RNAs (circRNAs) in the endothelium. LncRNAs comprise a heterogenic class of RNAs with a length of > 200 nucleotides and circRNAs are generated by back splicing. Angiolnc is based on the discovery of novel endothelial hypoxia-regulated lncRNAs and circRNAs by next generation sequencing. To begin to understand the potential functions of lncRNAs in the endothelium, we will study two lncRNAs, named Angiolnc1 und Angiolnc2, as prototypical examples of endothelial cell-enriched lncRNAs that are regulated by oxygen levels. We will further dissect the epigenetic mechanisms, by which these lncRNAs regulate endothelial cell function. In the second part of the application, we will determine the regulation and function of circRNAs, which may act as molecular sponges in the cytoplasm. Finally, we will study the function of identified lncRNAs and circRNAs in mouse models and measure their expression in human specimens in order to determine their role as therapeutic targets or diagnostic tools.

Keywords: angiogenesis,vascular biology,non coding rnas,myocardial infarction,atherosclerosis