Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hippocampus unites Memory Systems by preserving Sequential Order (MemUnited)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2025-05-31
Duration (months): 30.0
Total project cost (EUR): 222003.12
EU funding (EUR): 222003.12
Participants: 2
Project status: CLOSED

It is generally assumed that there are two distinct memory systems in the human brain: declarative memory supports memories for facts and events, while the procedural memory supports motor skills. However, recent evidence suggests that these multiple memory systems are less independent than originally thought and that the hippocampus, historically associated with declarative memory, is also involved in procedural motor memory. Accordingly, the project MemUnited (Hippocampus unites Memory Systems by preserving Sequential Order) proposes and tests an integrative framework that specifies the shared neural processes that support learning and memory across multiple memory systems. Specifically, given that declarative episodic and procedural motor memories consist of temporally organized sequences of events (e.g. order in which guests arrived at your dinner party) and movements (e.g. playing the piano), and the hippocampus is critical to preserve sequential order of experiences, I will investigate whether the neural mechanisms of sequential order processing supported by the hippocampus are jointly used in declarative episodic and procedural motor memory. To do so I will use state-of-the-art multivariate pattern analyses of functional Magnetic Resonance Imaging data acquired during the different phases of memory formation (i.e., encoding, consolidation and retrieval). Findings in the proposed research will fill a gap in the field by providing a detailed characterization of the role of the hippocampus in multiple memory systems. The findings will offer the opportunity to reconsider the historical models of memory classification and develop more integrative views of memory organization in general and hippocampal functioning in particular. Moreover, it will open new avenues for the development of integrative treatment of procedural and declarative memory deficits.

Keywords: human hippocampus serial order memory episodic memory motor sequence learning functional magnetic resonance imaging multivariate pattern analysis
Better understanding, intensified engagement, training and development in regional bio-based systems (Engage4BIO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Austria,Netherlands,Italy,Hungary,Belgium,Finland,Germany
Call: Improving understanding of and engagement in bio-based systems with training and skills development (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2499812.5
EU funding (EUR): 2499812.0
Participants: 21
Project status: SIGNED

Engage4BIO will strengthen circular, sustainable bioeconomy and sustainable regional development through engaging quadruple helix actors - taking into account their diversity of societal, economic and cultural perspectives from five regional bio-based systems (and five associated regions) in processes of design thinking, co-creation, (re)training and skills development. Based on their regional specificities (availability of biomass feedstock, level of technology, planetary boundaries and social capital) activities will be co-created, performed and (re-)shaped to their best advantage for each region. The regional bio-based systems focus on the five major value chains, namely circular and bio-based textiles (NL), agriculture and agro-food industries (HU), wood and interior (AT), bio-based and sustainable packaging (FI) and blue bioeconomy (IT). The embedding art and design in the activities the framework will boost the uptake to a) strengthen local governance feedback loops and respective governance models, b) to increase design thinking and co-create formats for training, retraining, mentoring and skills development and transfer fostering understanding and engagement in bio-based systems c) to co-create communication and awareness campaigns. The co-created and implemented activities result in fully open initiatives that advance skills transfer and development activities like (re-) training formats or mentoring programmes for various relevant stakeholders in bio-based value chains, and encourage the inclusion of citizen's knowledge and perception as well as the engagement of citizens, boosting a better-informed decision-making process and enhancing engagement and innovation. Thus, Engage4BIO framework will be designed in a transferable way, considering regional, natural and cultural differences and will be applicable in different European regions, also thanks to the involvement of networks and regions the partners include.

Keywords: engagement,training,co creation,art and culture,policy feedback loops,responsive government and society
Biomass Utilized To The Extended portfolio of Renewable Fuels with Large Yields (BUTTERFLY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Netherlands,France,Italy,Finland,Poland,Spain,Germany
Call: Demonstration of complete value chains for advanced biofuel and non-biological renewable fuel production (HORIZON-CL5-2022-D3-02, 2022)
Start date: 2023-07-01
End date: 2026-10-31
Duration (months): 40.0
Total project cost (EUR): 10530938.25
EU funding (EUR): 8318327.66
Participants: 11
Project status: SUSPENDED

The BUTTERFLY project will enable the flexible production of renewable DiMethyl Ether (rDME) and synthetic natural gas (SNG) from feedstocks of biological and non-biological origin. The project will demonstrate at TRL7 a flexible, efficient and low-cost process, combining indirect gasification with sorption enhanced DME synthesis (SEDMES) followed by methanation, to produce rDME and SNG. The ambition of BUTTERFLY is to propose and demonstrate a transformative biofuel production technology, allowing the use of renewable rDME and SNG in the energy and transport energy system, for hard to electrify sectors such as in shipping and steel industry. The BUTTERFLY project will generate 6 main innovations to the renewable fuel production sector: (1) achieving up to 97% carbon fixation in products (rDME and SNG) by using additional green hydrogen, (2) enhancing the biomass to fuel conversion efficiency by 15% compared to the conventional separated production technologies, (3) delivering a cost-effective technology: renewable fuel production cost will be 15-25 euros/GJ depending on green H2 addition based on a design of a commercial plant compared to reference values of 20-30 eur/GJ; the indicative production cost for rDME is 0.6-1.0 €/kgDME that will allow higher profit margin, (4) ensuring a mid-term applications of rDME and liquefied SNG as renewable fuels for a wide range of off-grid use cases including transport, domestic, commercial and industrial heating; as well as production of SNG for gas grid injection, (5) allowing the valorisation of 3 different categories of feedstocks for production of renewable fuels: mix of lignocellulosic biomasses, solid industrial waste, black pellets produced from wet organic residues and (6) delivering rDME according to ISO 16861 standard to be used as fuel and in accordance with REDIII. BUTTERFLY will ensure the replicability and deployment of the project's solutions in EU, with the aim of reaching 250 units of various sizes by 2050.

Keywords: renewable dme,renewable sng,indirect gasification,sorption enhanced dme synthesis,methanation,feedstocks of biological and non biological origin,flexibilty,cost effectiveness,demonstrator
Fighting Resistant Bacteria with Antimicrobial Peptides (FireBacteria)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Czechia
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Antimicrobial resistance (AMR) is a critical global health threat, associated with approximately 5 million deaths annually and a severe economic burden. To combat this threat, this project aims to advance the development of our de novo designed antimicrobial peptides (AMPs) towards novel therapeutics. These AMPs, developed within our ERC Consolidator project "Peptide Killers of Bacteria", utilize a mechanism distinct from traditional antibiotics, namely the disruption of bacterial cell membranes. This potentially novel class of antibiotics has already achieved nanomolar antibacterial activity, while exhibiting low toxicity to human cells in our in vitro tests. The susceptible bacteria include antibiotic-resistant strains of the Gram-negative A. baumannii, K. pneumoniae, and P. aeruginosa, which are on the CDC's and WHO's list of priority pathogens. Within this project, we aim to perform key preclinical tests with our AMPs. Our goal is five-fold: [1] determine the activity spectrum against genetically diverse bacterial species and strains; [2] evaluate the stability and efficacy of our AMPs in biological fluids, as well as their ADMET properties; [3] expand the scope of our preliminary in vivo data with murine models to include an additional administration route and infected sites; [4] analyze the prevalence and incidence of target infections to better understand the market size and societal impact; and [5] investigate the market potential, secure intellectual property rights, and develop a business strategy for clinical development. Successful implementation of this project will pave the way for future clinical testing and development of our AMPs, which could lead to effective treatments for the emerging AMR crisis of antibiotic-resistant infections.
Promoting ocean and water literacy in school communities (ProBleu)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Coordination and support actions
Countries involved: Spain,United Kingdom,Lithuania,Portugal
Call: Student and school activities for the promotion of education on ‘blue’ sustainability and the protection of marine and freshwater ecosystems (HORIZON-MISS-2022-OCEAN-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 1792562.5
EU funding (EUR): 1792562.5
Participants: 6
Project status: SIGNED

ProBleu will expand and support the Network of European Blue Schools, attract a wide diversity of new members, improve ocean and water literacy across school communities, and contribute to the objectives of the Mission, in particular (1) to protect marine and freshwater ecosystems and biodiversity, and (2) to prevent and eliminate pollution. ProBleu recognises that a significant change in environmental education is needed to foster broad societal responsibility towards oceans and waters and to encourage related behavioural change. ProBleu will develop and offer a pool of innovative, practical resources based on methodologies of Open Schooling. Besides several actions to promote, encourage participation in, and increase the diversity of the Network, two resources, currently lacking from the majority of school curricula, are explored in ProBleu: (1) those related to what is collectively known as ‘citizen science’, with work undertaken by educators together with communities to advance science, foster a broad scientific mentality, or encourage democratic engagement, which allows society to deal rationally with complex modern problems, and (2) the interaction with scientists in the field. Collecting and analysing data through citizen science ensures that student activities contribute directly to fostering their ocean and water literacy. Students engaging with the work of scientists (e.g. through direct interaction, or following the work on ocean research cruises) have shown improvements in learning in the past, but this opportunity tends to be limited to relatively few or privileged schools. These resources will be complemented by stimulating the connection between people and the places where they live. By fostering relationships between the school communities and their local waters, ProBleu will assist schools in developing project activities related to the Mission.

Keywords: open schooling,ocean literacy,freshwater literacy
Foundations of Timed-Release Cryptography (FTRC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1897685.0
EU funding (EUR): 1897685.0
Participants: 2
Project status: SIGNED

Cryptography has repeatedly revolutionized modern technology via its "easy-or-infeasible" design paradigm, classifying computations as either "easy" or "infeasible". Nowadays, however, this foundational paradigm is insufficient for a host of rapidly evolving applications, and a fine-grained accounting of sequential timing guarantees is urgently needed. This has recently led to substantial interest in the classic yet insufficiently-explored vision of timed-release cryptography, enabling cryptographic systems to rely on such guarantees realistically. Despite the significant attention, the vision of timed-release cryptography is still alarmingly far, and the landscape of our current knowledge must rapidly change to facilitate its deployment: Timed-release cryptography suffers from an extreme lack of candidate schemes, and the security of its main candidates is provided directly by assumption (with essentially no supporting evidence other than the lack of successful "speed-up" attacks). This proposal aims to establish robust foundations for timed-release cryptography by obtaining an in-depth understanding of the computational landscape, building blocks, and schemes required for realizing its premise. Specifically, I plan to direct our effort towards addressing the following three fundamental objectives, which span a broad and interdisciplinary flavor of research directions: (1) Explore sources of computational hardness that enable to base timed-release cryptography on the hardness of well-studied problems, (2) identify the extents to which timed-release primitive building blocks require cryptographic structure and can be utilized in designing more complex schemes, and (3) construct concrete such schemes offering a wide range of security and functionality guarantees. I strongly believe that substantial progress towards our objectives will enable us to realize the premise of timed-release cryptography, and will have a long-lasting impact on cryptography.

Keywords: cryptography foundations
Cultural Literacies’ Value in Europe (CLiViE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Finland,Czechia,Netherlands,Latvia,Poland,Lithuania,Germany,Italy
Call: Promoting cultural literacy through arts education to foster social inclusion (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 2999890.0
EU funding (EUR): 2999890.0
Participants: 13
Project status: SIGNED

The Cultural Literacies’ Value in Europe (CLiViE) project develops and applies a Theory of Change (ToC) methodology and Social Return on Investment (SROI) framework to increase our understanding of the value of cultural literacy through arts-based education on social cohesion. It will be delivered through four main phases: it ‘maps’ arts-based education within the context of cultural literacy learning across different learning environments and over different stages of a young person’s education; it ‘evaluates’ arts-based education to help identify and assess their actual outputs and outcomes; it ‘values’ arts-based education activities through calculating its impact to further contribute to our understanding of the 'where', 'when', 'what' and 'how' young people’s cultural literacies are developed, and differentiated in various learning environments; and it ‘practices’ pedagogies through developing an innovative set of practices and materials to support art-based educators to develop social justice and inclusion and improve the lives of young people through collaborative pedagogy. It has been designed to meet the three main research outcomes of the work programme topic: the ToC methodology and SROI framework for cultural literacies will directly increase our understanding of the value of cultural literacy on social cohesion; the evidencing of value in arts-based education and the collaborative pedagogy practices in cultural literacy through the co-creation of communities of practice (COPs) and a professional development programme (PDP) for arts educators will support the targeted commissioning of activities that will increase cultural literacy in Europe; and the innovative methodology for data gathering (and engaging) through emotional cartography allows young people to find a voice through more effective initiatives to foster cultural literacy around European cultures.

Keywords: social cohesion,theory of change,sroi,arts based education
The dawn of the Hadean atmosphere (DAWN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

During the Hadean eon, the first 500 million years of Earth's geological history, the atmosphere underwent its most dramatic transformations. An abundance of greenhouse gases prevented runaway cooling in the face of a fainter Sun, but the concentration, chemistry, and decline rates of these gases are unknown. Retracing this intriguing metamorphosis is impeded by the scarcity of Hadean samples, a vast parameter space, and volatile flux estimates that largely rely on empirical extrapolations. Here, I aim to decipher the formation and chemical evolution of the Hadean atmosphere using a pioneering multi-scale approach, bridging atomic to planetary scales. At the foundation of my project lies a unique combination of state-of-the-art atomistic simulations that cover different length and time scales. With ab initio calculations, I compute equilibrium thermodynamics and thermochemistry at the nanoscale. Subsequently, I employ these ab initio results to train new advanced machine-learning interatomic potentials tailored for liquid-vapor and vapor-solid interactions. These simulations quantify the devolatilization rates from the cooling magma ocean and reconstruct the volatile cycle during its crystallization, including the effects of redox changes and fugacity variations. I incorporate the results of the atomistic simulations into thermochemical calculations and global circulation modeling. In this way, I simulate the behavior and evolution of the atmosphere in Hadean, retrace the major volatile fluxes between geological reservoirs and their contributions to the atmosphere, and dynamically integrate gas losses to space, incoming meteoritic contributions, and fast-changing surface conditions, including the appearance of the hydrosphere. This modeling also gives feedback on the surface state that constrains the atomistic simulations. Thus, I can chart a comprehensive evolutionary path of the Hadean atmosphere and bridge the gap to the better-constrained state of the Archaean.

Keywords: habitability,atmosphere,hadean,early earth,magma ocean,degassing,volcanos,ab initio simulations,machine learning,artificial intelligence,molecular dynamics,atmospheric chemistry,volatiles,lava vapor,extreme conditions,thermodynamics,thermochemistry,global circulation model