Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Organizing for sustainability: The importance of Formalization of control and Learning In the Transition Towards Sustainability (FLITTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

Sustainability has become a strategic priority for both practice and theory. The quest for sustainability has already started to change the competitive landscape and has become a major driver for innovation. Innovation and more precisely sustainable new product development allows the organization to improve competitiveness while simultaneously securing environmental sustainability. However, developing sustainable products poses many challenges. Processes and products need to be re-invented, controlling systems have to integrate new sets of data, external and internal communication strategies require revisions and basic values and knowledge systems need to adapted. Central to these challenges is thus to ability to learn, the ability to acquire new knowledge and integrate that knowledge into the newly developed products. The main objective of this research project is therefore to investigate to what extent learning from previous new sustainable product development projects (sustainable NPD) affects subsequent sustainable NPD performance. More precisely, this project investigates what types of experience with sustainable NPD projects are most beneficial and distinguishes on the one hand the impact of successful versus failed sustainable NPD projects and on the other hand the influence of internal versus external sustainable NPD project learning experiences. Furthermore, it explores to what extend this relationship is moderated by the types of controls that are used to guide those sustainable NPD projects. For this purpose a combination of experiments and surveys will be used.

Keywords: e106 natural resources and environmental economics,sustainability,new product development,organizational learning and control
Novel isotopic constraints on the environmental impact of continental flood basalt eruptions (ISOVOLC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-06-01
End date: 2016-05-31
Duration (months): 36.0
Total project cost (EUR): 282561.0
EU funding (EUR): 282561.0
Participants: 1
Project status: CLOSED

Continental flood basalt volcanism is characterised by the repeated eruption of huge batches of magma, producing enormous basaltic provinces over relatively brief intervals of time, and delivering large quantities of volcanic gas to the atmosphere. The release of gases and aerosols during CFB volcanism is thought to have had a significant impact on the atmosphere, ocean chemistry and climate – with such eruptions often linked with mass extinction events that punctuate the history of life on Earth. The environmental effects of flood basalt volcanism, in terms of atmospheric loading, is a function of the amount, rate and source of volatiles released by the eruption, as well as the mechanism of volatile delivery to the atmosphere. This research proposes a novel isotopic approach, specifically the application of the chalcophile zinc and copper stable isotope systems coupled with the radiogenic rhenium-osmium system, to quantify these criteria. The ultimate aim of this research is to constrain the environmental impact of atmospheric volatile input produced by individual continental flood basalt eruptions. This study will allow us to deduce whether a single eruptive event is enough to trigger biological crisis, or whether multiple eruptions are required to cause deleterious effects.

Keywords: geochemistry,isotope geochemistry,igneous petrology,climatology and climate change
Preparation and characterization of photo-responsive microcapsules based on azobenzene derivatives, for controlled delivery of active agents under visible light. (PHOTOCAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-10-01
End date: 2016-09-30
Duration (months): 36.0
Total project cost (EUR): 254925.9
EU funding (EUR): 254925.9
Participants: 1
Project status: CLOSED

Encapsulation process is described as the capture of a compound into a coating material. Besides encapsulation technology is currently the best solution available on the market for the delivery of dedicated components/materials in different applications such as: food ingredients, perfumes, drugs, dyes, acids, pesticides and herbicides, etc. The main strategic objective of PhotoCap is to create an innovative platform for interdisciplinary research with the aim to accelerate the adoption of microcapsules-innovative solutions with significant contribution to European excellence. The research objective of the PhotoCap project focuses on development and testing of new photo-control release microcapsules for innovative breakthrough applications with high impacts on: environmentally-friendly production methods, health protection and increase of citizen daily life standard, with decreasing its cost. The novelty of this project will be preparation of new smart microcapsules based on azobenzen derivatives monomers containing electron-donating groups ortho to the azo moiety. It means that the controlled release of the encapsulated active agent will occur by visible light irradiation from sun illumination. During the PhotoCap I wish to develop and explore encapsulation and triggered release using as a model non-toxic substances such as perfumes under mild, consumer-relevant irradiation conditions. I wish to explore the incorporation of photo-responsive trigger materials into different encapsulation wall chemistry (e.g., polyamide, melamine formaldehyde), and seek to understand the stability and release behavior under different conditions of irradiation. During reintegration phase I wish to apply these new smart microcapsules to real products from EU market, check their stability in these products and disseminate the results in ERA in order to increase its attractiveness.

Keywords: encapsulation,microcapsules,azobenzene,photo-control release,liquid crystalline elastomers,interfacial polycondensation
Autodigestion in Hemorrhagic Shock and Acute Heart Failure: a Cell-to-System Approach to Pathophysiology and Therapy (CELSYS SHOCK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-01-01
End date: 2016-12-31
Duration (months): 36.0
Total project cost (EUR): 261627.6
EU funding (EUR): 261627.6
Participants: 1
Project status: CLOSED

The relationship between hemorrhagic shock, systemic inflammatory response syndrome, and multiple organ failure has long been investigated, but no accepted tissue injury mechanism has been assessed. This shortage of understanding of the basic pathophysiology limits the clinical management of one of the most important medical conditions from a mortality point of view, with implications in anesthesia and critical care. In this proposal, a new approach to the study of the molecular triggers of shock is proposed, on the basis of the innovative framework of the "Autodigestion Hypothesis". The goals are to identify the root cause of hemodynamic instability and specifically of shock induced acute heart failure, and to propose therapeutic countermeasures for its prevention and treatment. An animal model of hemorrhagic shock in the rat will be used for experimental induction of hemorrhage and resuscitation, with the aim of shedding light on the potential cleavage of important receptors in the heart due to the proteolytic action of digestive enzymes and matrix metalloproteinases. A multiscale approach to data analysis will be formulated to describe the pathogenesis of shock, from the cellular and molecular phenomena to its system wide symptoms, and to predict the occurrence of hemodynamic instability, hypotension and heart failure from the information conveyed by hemodynamic vital signs which are commonly accessible in critical care or emergency settings. The training implications of this project will enable the fellow to receive high level training on state-of-the-art molecular cardiovascular physiology and disease, and to complement his current skills in hemodynamic signal processing and modeling, granting him the opportunity to expand his current interests and background and to achieve a complete profile and independence as a researcher in the cardiovascular field.

Keywords: biomedical engineering,shock,critical care,autodigestion,acute heart failure,hemodynamic instability,multiscale modeling,cardiovascular disease
Novel approaches for enhancing the treatment of drinking water by ultrafiltration and evaluating the mechanisms at nano-scale (WATERULTRAFILTRATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The application of membrane technology in the treatment of drinking water has been rapidly increasing in recent years, and particularly the process of ultrafiltration (UF). While some expertise and research activities relating to UF technology currently exist within the European Union, the applicant, Dr Yu, of the Chinese Academy of Sciences, has unique knowledge and research experience of UF pre-treatment methods, which are essential to the optimal performance of the UF process. His proposed fellowship offers an important opportunity for collaboration between two internationally leading research institutions to advance the technology and facilitate the transfer of Dr Yu’s expertise to Imperial College London and the wider European research community. The proposed Marie Curie fellowship will concentrate on developing novel approaches to enhancing UF performance to achieve higher quality treated water cost-effectively and with greater operational efficiency (e.g. through reduced membrane fouling). The fundamental mechanisms involved in these processes will be investigated at nanometer-scale, which will expose the interactions between floc particles, activated carbon and membrane surfaces. In addition, the combination of coagulation-UF treatment with downstream processes, involving a second stage of UF preceded by ozone oxidation and organics adsorption via waste-derived activated carbon, to further enhance water quality, will also be evaluated in this project. In conclusion, the proposed project is expected to provide important and valuable results for the European research community and for water utilities using UF processes in water treatment plants currently, or planning new plants in the future.

Keywords: v201 environmental engineering and geotechnics
Developing single-molecule switches for applications in nanoscale organic devices (SINGLE-MOLEC-SWITCH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-10-15
End date: 2015-10-14
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

Today, one of the central themes in the Nanoscience is Molecular Electronics which relies on the ability to measure and control electrical current through molecular scaffolds. As in the case of conventional semiconductor electronics that took several decades of research to reach commercial applications, the concept of using few molecules or even a single molecule as active components in electronic devices is now closer to reality. Molecular Electronics research continues in deepening our understanding of the properties of single molecules and is anticipated to lead to novel organic (opto)-electronic devices. However, the question remains “when will this fundamental science turn into a commercial technology?” The answer for this question is “soon”. However, this field is still in its infancy and there are several unsolved issues, the most critical one being optimizing molecular contacts with electrodes and controlling current flow through molecular junctions. In this project, we propose to use STM break-junction approaches to measure the properties of single molecules using novel molecular anchoring chemistries to bridge molecules between electrodes. In particular, we intend to integrate newly developed surface chemistry reactions to go a step further in the stability of molecular junctions. Further, we intend to investigate conducting electrodes other than the common gold electrodes because the latter are not ideal for commercial applications. With the opportunity of having robust and low contact-resistance molecule-electrode interfaces, we intend to control the electrical flow through single molecules using electrochemical, light irradiation, solvent and mechanical stress stimuli. This project is hoped to gain fundamental insights into the electrical properties of single molecules, develop novel molecular switches and bring the Molecular Electronics field a step further towards real applications.

Keywords: c102 nanochemistry,c105 surface science,c121 surface modification,c128 nanomaterials,c130 intelligent materials - self assembled materials,c101 physical chemistry
Studying Micro-Scale Socio-Ecological Development In Marginal Zones: An Integrated Methodology (MISSED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

The proposed research is to develop a multi-disciplinary approach to investigate socio-ecological networks in marginal regions at local scale. Locality and marginality have been often overlooked but are focal points in understanding the complex relationships between environment and human populations. Marginal alluvial zones bore witness to the development of agricultural and subsequently urban societies, and continue to represent one of the most exploited (but fragile) environments on our planet. The case study of this proposal focuses on the unique alluvial system of the 'oasis' environments of Central Asia. This research will develop a novel approach in order to identify and interpret local and sub-regional environmental, and ecological 'niches' and their possible role in social change. The small scale approach recognises that there are dynamic local mechanisms, both environmental and anthropogenic, that have often been missed in more traditional 'macro-level' approaches; it is essential to recognize and understand these processes in order to fully grasp the dynamics of marginal occupation. In addressing these questions, the research utilises an integrated method combining remote sensing, geoarchaeology and palaeogeography in order to develop socio-ecological models applicable for examining broader questions of marginality in comparative perspective. The first phase of the research employs an investigation of high-resolution and multi-spectral imagery, in conjunction with digital elevation models, to identify potential micro-environmental regions. Based on these findings, a robust geoarchaeological study will be conducted in order to identify sub-surface characteristics of soils and alluvial sediments. This approach will facilitate the investigation of diachronic changes and, in conjunction with the remote sensing analysis, will enable the development of a diachronic socio-ecological model for this marginal region.

Keywords: s108 human and social geography,s401 archaeology - archaeometry - landscape archaeology,v101 environment and sustainability
Modelling effects of exposure to mixtures of chemicals on a multi-species level (BIOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Predicting effects of chemicals in real life situations is a very complex undertaking, but also very important in terms of the sustainability of our environment. The complexity lies in the enormous variation that is found in real life situations. A variety of organisms is exposed to a variety of chemicals, with a different composition in space and time. This is far from a laboratory situation, where single organisms are exposed to mostly single compounds in a homogeneous environment. As 20 different compounds already allow more than one million possible mixtures we need tools in the form of mathematical models to assess real life exposure situations. These tools must be able to extrapolate from one compound to a mixture containing that compound, from one compound to a compound that was not measured, from effects at some point in time to different points in time and from one species to another. The first steps in the development of such a model were taken during my PhD research, we showed that it is possible to predict effects on a single species, exposed to a real life mixture of metals, pesticides, PAHs, PCBs, nutrients, salts, etc. with great accuracy. The aim of the proposed research is to extend the current single-species approach to a multi-species approach. This would be an important step forward as such an approach is of great practical importance in environmental quality management, understanding and predicting effects of chemical pollution on biodiversity and in understanding and predicting environmental effects caused by accidents and spills. We will build on the existing model, further develop the model to predict effects for untested species, apply QSAR approaches to predict effects for untested compounds and make use of existing experimental data gathered by the UK Environmental Agency on exposures, effects and the occurrence of species to evaluate the approach.

Keywords: mixtures,effects,exposure,multi-species,modelling,environmental pollution
Modelling Steroidogenesis (MOST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Congenital Adrenal Hyperplasia (CAH) ranks amongst the most common inherited metabolic diseases. It represents a group of autosomal recessive disorders caused by mutations in genes encoding for steroidogenic enzymes. Steroid 21-hydroxylase (CYP21A2) deficiency (21OHD) caused by mutations in CYP21A2 is the most common form of CAH. The severity of the clinical phenotype correlates with residual CYP21A2 activity. About 500,000 individuals within the EU suffer from CAH leading to a significant health burden on health care provision. No innovative treatment strategies have been developed to avoid overtreatment with glucocorticoids. This is mainly due to a lack of understanding of the pathophysiologic impact of CYP21A2 mutants according to the severity of their functional impairment. The proposed project will follow an innovative research strategy to dissect the phenotypic impact of different CYP21A2 mutations on systemic homeostasis employing zebrafish. Complete and partially inactivating variants of zebrafish 21-hydroxylase (zCyp21a2) modelling human CYP21A2 mutations and mimicking different human disease severities will be tested for their in vitro enzymatic properties. In addition, complete and partial Cyp21a2 mutant zebrafish will be generated to study the systemic consequences during development and in adults by morphological analysis, expression studies, and steroid profiling by LC/MSMS. Different degrees of impaired steroidogenesis are predicted to result in differential systemic consequences. The obtained data will discover novel pathways important to the pathophysiologic understanding of 21OHD and inborn errors of steroidogenesis in general. In conclusion, this highly innovative project will combine state-of-the-art methodologies to study inborn errors of steroidogenesis in an individualised way. The proposed studies will hopefully pave for novel personalised therapeutic approaches and in addition provide an ideal advanced training platform.

Keywords: l403 endocrinology,cah,congenital adrenal hyplerplasia,dsd,disorders of sex development,zebrafish,genotype-phenotype correlation