Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Predicting the Future of Island Biodiversity: Integrating Traits to Decipher Species Turnover Dynamics (Isl-Traits)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2027-01-01
End date: 2031-12-31
Duration (months): 60.0
Total project cost (EUR): 1499805.0
EU funding (EUR): 1499805.0
Participants: 1
Project status: SIGNED

Global change is altering vegetation, with climate zones shifting poleward and species distributions changing. Rising sea levels, land-use change, and invasive species further modify natural vegetation, leading to the reassembly of native communities. However, the rates and patterns of community changes across different vegetation types, along with their consequences for biodiversity, remain unclear. This proposal explores the effects of global change on coastal islands and mainland habitat fragments using resampled vegetation data. Islands, which support unique biodiversity and are particularly threatened by rising sea levels and invasive species, serve as models for understanding the effects of fragmentation on the mainland. The overarching aims of this proposal are to: (i) advance island biogeography by characterizing plant ecological strategies on islands through functional traits, focusing on immigration and extinction dynamics; (ii) describing potential futures under global warming; (iii) compare assemblage dynamics on islands with those in fragmented mainland habitats; and (iv) synthesise findings towards effective conservation strategies for coastal island vegetation. The strengths of this proposal include its focus on islands as simplified systems, the use of a unique dataset with resurveyed vegetation, and the synthesis of findings from both island and mainland habitats. Understanding differences between island and mainland assemblages will be key to predicting the future of island ecosystems.

Keywords: global change biology,functional ecology,island biogeography,plant ecology
CenTral and PeRipheral NervoUs SyStem acTion of GIPR in ObEsity and Diabetes (TRUSTED)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1999928.75
EU funding (EUR): 1999928.75
Participants: 1
Project status: SIGNED

Obesity is a major health threat, but efficient pharmacotherapies are yet not available. First demonstrated by us to decrease body weight and hyperglycemia in obese mice, unimolecular co-agonists at the receptors for glucagon-like peptide-1 (GLP-1) and the glucose-dependent insulinotropic polypeptide (GIP) efficiently corrected obesity and type-2 diabetes in recent phase 3 clinical trials. While GLP-1R/GIPR co-agonists are safe and effective, GIP regulation of metabolism remains enigmatic, with GIPR agonists and antagonists both decreasing body weight and blood glucose. My lab recently identified the CNS GIP receptor as a key regulator of energy metabolism, by showing that CNS loss of Gipr renders mice resistant to GIP-induced body weight loss. Emphasizing the relevance of this discovery, we showed that GLP-1R/GIPR co-agonism loses its superior body weight lowering potency over GLP-1R agonism in CNS-Gipr ko mice. My studies now finally enable assessment of how GIPR (ant)agonists and GLP-1R/GIPR co-agonists regulate energy and glucose metabolism. Whether GIPR (ant)agonists improve metabolism through central and peripheral mechanisms, which central regions/neurons/cells are targeted by GIPR (ant)agonists and by GLP-1R/GIPR co-agonists and the molecular mechanisms through which they control energy and glucose metabolism, remain unknown. In this project I will solve the conundrum of how GIPR (ant)agonists and GLP-1R/GIPR co-agonists improve energy and glucose metabolism. I will map regional GIPR distribution (Aim 1), identify the central target regions of GIPR (ant)agonists and of GLP-1R/GIPR co-agonists (AIM 2), delineate their cellular and molecular signal mechanisms (AIM 3) and assess functional relevance of GIPR signal modification in key neuronal/cellular populations and the periphery (AIM 4). My studies will significantly advance the knowledge on how GIPR signaling regulates metabolism and will illuminate the paths for the development of future obesity drugs.

Keywords: obesity and diabetes
Democracy at work in Europe: actors, cultures and models in historical and comparative perspective (1973-2023). Case studies from Germany, Spain, Italy and Portugal in the railway and energy sector (EURODEM_WORKSIPG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Germany,Italy,Portugal,Chile
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 826650.0
EU funding (EUR): 826650.0
Participants: 15
Project status: SIGNED

Industrial democracy has a centuries-old and European origin. After its momentum during the second post-war period and the flowering of experiences during the 1970s, it sank into relative decline in the context of the triumph of the neoliberal perspective, with changes in global economic governance and a new process of globalization. In the mid-90s and, in particular, following the effects of the Great Recession of 2008, the topic once again gained interest that has continued to the present day. The objective of EURODEM_WORKSIPG is to carry out a historical analysis of this issue in its European dimension between 1973-2023. It is a comparative study of the changes/continuities of the actors (employers and workers) and work cultures from 4 countries (Germany, Spain, Italy and Portugal), 2 productive sectors (rail transport and energy sector), and 8 business corporations, public and private in nature. It adopts an interdisciplinary perspective, adding sociological approaches, political theory and law to the methodology of history. Experienced academics and young researchers will collaborate, with planned assignments and exchanges, in an innovative project that contributes to strengthening the conceptual bases of the problem. Synergies with extra-academic partners will allow the construction and consolidation of an international research network. The expected cross-sector impact will provide policymakers, business and union leaders, and members of labour NGOs with recommendations to address democracy at work. There will be wide dissemination and awareness among citizens about a better future of work as a social link, currently weakened, an intermediate social space of democratic reinforcement, promoter of equality and social justice, in line with the objectives of Horizon Europe, and brake against authoritarian impulses inside and outside the company.

Keywords: democracy at work,company,syndicalism,southern europe,current history
Towards an AI-native, user-centric air interface for 6G networks (CENTRIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Germany,France,Denmark,Italy,Switzerland,United Kingdom,Finland,Spain
Call: Wireless Communication Technologies and Signal Processing (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2025-06-30
Duration (months): 30.0
Total project cost (EUR): 4512778.06
EU funding (EUR): 4215999.0
Participants: 14
Project status: SIGNED

CENTRIC proposes to leverage Artificial Intelligence (AI) techniques through a top-down, modular approach to wireless connectivity that puts the users’ communication needs and environmental constraints at the center of the network stack design. It all starts with the users’ objectives and application-specific requirements. Then, AI techniques are used to create and customize tailor-made waveforms, transceivers, signaling, protocols and RRM procedures to support these requirements. This is the user-centric AI Air Interface (AI-AI) that CENTRIC will enable. To guarantee that CENTRIC’s AI-AI can be implemented in practice, we will also explore and develop innovative hardware computing substrates with realistic and AI-AI-compatible energy-efficiency properties. This includes novel electronics such as neuromorphic computing and mixed analog-digital platforms. CENTRIC will make this possible by advancing theory, algorithms, hardware co-design, and training and monitoring environments based on digital twins. We will focus on providing the desired quality of experience (QoE) to a given user, or type of users, while optimizing spectrum usage, minimizing energy consumption and guaranteeing EMF compliance. The results of CENTRIC will be validated and demonstrated in laboratory prototypes and its breakthroughs will enable future 6G use-cases, such as self-driving vehicles, the internet of nano bio-things, or multi-sensory holographic communications.

Keywords: 6g,ai,air interface,wireless,waveforms,transceivers,protocols,semiconductor,digital twin,hardware co design
Spontaneous Finnish Humanitarian Aid as Catalyst for Independent Estonia: From a Personal Touch to the Success of a Nation (Fin-Est Connection)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-08
End date: 2026-01-07
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: SIGNED

The last five years of Soviet rule marked by perestroika and glasnost enabled Estonians not only to communicate their dissent but also to build relationships with people on the other side of the Iron curtain. One of the first types of contacts to start popping up were those with neighboring Finns. Spontaneous unofficial person-to-person networks sprung into action delivering clothes, medicine, technology, toys and food to Estonia. This gave Estonians a “taste of freedom”: It not only helped to kindle the fire of pro-independence movements but also provided a great starting position for the budding country and might account for some of the surprising success it has had during subsequent decades, especially when compared with other post-Soviet states. Finnish humanitarian aid to Estonians during the re-independence era is among some of the most basic narratives in Estonia, but there is hardly anything researched or written about it. More than thirty years have passed since the first contact was made and some of the women and men in the front lines of this “diplomacy of the people” have begun to fade away, leaving this gap in historiography in a very perilous position, which requires urgent attention. My mixed-methods research will encompass oral history, anthropological fieldwork, archival research and quantitative analysis to unearth this untold story in order to understand the role of spontaneous humanitarian aid from Finns to Estonians had in the late 1980s and early 1990s. The results of this international and multidisciplinary project will have the discursive power to create a reinterpretation of European Cold War history by bringing out hidden, silenced or under-researched networks and relationships between citizens on both sides of the Iron Curtain. The results may have a wider societal impact by providing good practices and learned lessons relevant for meeting the EU goals of cohesive development within the EU and its neighbouring regions in peace and war.

Keywords: cold war,soviet,post soviet,finland,estonia,baltic sea region,social networks,humanitarian aid,personal relationships,oral history,anthropological fieldwork,gender
NanoEcho - the first imaging modality for accurate assessment of rectal cancer metastatic spread in lymph nodes (NanoEcho)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

NanoEcho is developing the world’s first Magnetomotive Ultrasound (MMUS) system for accurate, non-invasive detection of lymph-node metastases in rectal cancer. This breakthrough innovation introduces a new functional imaging modality that detects magnetic motion of biocompatible nanoparticles in tissue, visualising metastatic spread with unparalelled precision in real time - a diagnostic capability unattainable with existing MRI, CT, or ultrasound systems. Every year, over 700,000 rectal cancer patients worldwide undergo invasive surgery because current imaging limitations cannot reliably confirm cancer spread. Up to 70 % of these operations are unnecessary, leaving patients with life-altering stomas and costing healthcare systems more than €18 000 per case. NanoEcho’s MMUS system fills this critical gap, enabling clinicians to identify patients suitable for organ-preserving surgery and to perform radical procedures only when truly needed - reducing overtreatment, complications, and healthcare costs while improving quality of life. NanoEcho’s system combines a handheld ultrasound probe with integrated magnetic actuation, a proprietary signal-processing algorithm (nTrace™), and a GMP-grade iron-oxide nanoparticle contrast agent. The technology has achieved TRL 6, having completed first-in-human validation confirming safety, tolerability, and imaging reproducibility under ISO 13485 certification. In this EIC Accelerator project, NanoEcho will validate clinical performance in rectal-cancer patients, complete CE marking under MDR (Class IIa), and prepare market launch in Sweden, Germany, and Italy. By establishing functional MMUS imaging as a new diagnostic standard, NanoEcho aims to transform cancer staging worldwide - empowering clinicians, protecting patients, and reinforcing Europe’s leadership in advanced medical imaging.

Keywords: magnetomovtive ultrasound,mmus,magnetic nanoparticles,rectal cancer,oncology,colorectal cancer,lymph node,precision oncology,functional imaging,organ preserving,non invasive diagnostics
Advanced biomarker discovery for earlier diagnosis and improved prognosis of NAFLD stages via high resolution mass spectrometry. (RENAISSANCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: CLOSED

Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of nearly 25% i.e., affects one quarter of the adult population. Early phase NAFLD is reversible and can be treated, but it may progress towards life-threatening stages such as non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). The conventional diagnosis of NAFLD stages requires liver biopsy and is time-consuming and costly and there is an urgent need to identify biomarkers that can be applied in routine clinical settings, such as through blood-based testing. The identification of blood biomarkers would support earlier diagnosis and improved assessment of prognosis, ultimately supporting preventive/intervention measures to avoid progression to late stage liver disease and thus saving lives. In RENAISSANCE, a state-of-the-art liquid chromatography-high resolution mass spectrometry (LC-HRMS) metabolomics screening will be conducted upon the blood and blood-derived exosomes of a unique deeply phenotyped cohort of NAFLD patients for molecular biomarker discovery. Notably, exosome analysis shows promise for the identification of novel disease signatures but has yet to be applied to characterize NAFLD, providing high potential for the identification of new diagnostic/prognostic biomarkers for NAFLD. Furthermore, the LC-HRMS screen will be supported via targeted assays of redox metabolites and protein markers of acute inflammation. The integration of non-target and target data will provide insight into the underlying mechanisms of disease progression and further knowledge about potential causative factors of NAFLD.

Keywords: nafld,metabolomics,biomarker discovery,liver diseases,nash
Concept Visualization for Enhanced Explainability in Tabular Deep Learning (CONVEYTab)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

The EU's GDPR and the new EU AI Act impose strict requirements on AI systems, especially in high-risk domains like healthcare. These regulations demand transparency and meaningful explanations for automated decisions to ensure adequate human oversight. State-of-the-art eXplainable AI (XAI) methods, such as LIME and SHAP, attempt to meet these demands with low-level explanations. However, these methods often yield inconsistent and decoupled results from high-level concepts that domain experts like physicians use in decision making. In contrast, Deep Learning (DL) models that generate concept-based explanations during training offer more robust and consistent outcomes. Despite their promise, concept-oriented DL models for tabular data remain underdeveloped, with the recent Tabular Concept Bottleneck Models (TabCBMs)—a family of interpretable, self-explaining DL models designed to learn and articulate high-level concept explanations for tabular data as an emerging yet unexplored solution. CONVEYTab will advance TabCBMs by creating the first Visual Analytics (VA) framework that enhances interactivity and tests their real-world applicability. This framework will be realized through several VA systems tailored for medical professionals, enabling them to create, refine, explain, and compare DL model concepts in real time. This will ensure AI predictions are transparent, aligned with domain expertise, and compliant with EU regulations. CONVEYTab adopts a strong interdisciplinary approach, integrating expertise from life sciences, computer science, and cognitive science to meet the needs of the public sector and broader society. The research will be conducted at Utrecht University's Information and Computing Sciences Department under the supervision of Prof. Dr. Alexandru C. Telea, an influential scholar with extensive experience in DL and XAI. This project will help patients with motion disorders and intestinal parasites and position me as a leading VA for XAI researcher.

Keywords: visual analytics,information visualization,data visualization,explainable ai,human centered ai,concept based explanations,concept learning,tabular deep learning,tabular data,healthcare
Electrical Modulation of Elastic Moduli (Elmo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

How could a textile change its feel upon the push of a button? While we are accustomed to visual displays and loudspeakers, interactive tactile perception largely eludes our experience. Textiles that change their pliability and texture would allow for communication using our sense of touch. Potential applications abound, from human-machine interfaces for robotics to new forms of virtual reality. To facilitate such a tuneable mechanical response, materials are needed whose stiffness can be altered. This project will use conjugated polymers to realise stimuli-responsive materials. The developed materials will be spun into fibres and yarns, which will be integrated into prototype textile devices that can undergo a reversible change in pliability and texture. The explored materials science concepts will open up a new line of research in the blossoming field of organic electronics, while the application-oriented part of the project opens new horizons for the interdisciplinary field of wearable electronics.

Keywords: conjugated polymers,conducting polymers,mechanical properties,stimuli responsive polymers,electrochemistry