Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next Generation Taxonomy: Ciliophora and their bacterial symbionts as a proof of concept (NGTax)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Germany,Germany,Italy,Ethiopia,South Africa,Germany,Germany,Italy,China,Russian Federation,Finland,United States,Kenya
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-06-01
End date: 2026-03-31
Duration (months): 70.0
Total project cost (EUR): 1274200.0
EU funding (EUR): 984400.0
Participants: 15
Project status: SIGNED

Taxonomy - the science of defining and naming groups of biological organisms based on shared characteristics - faced a significant crisis in the last decades and nowadays a rejuvenation of this discipline is required. For this reason, we recently proposed the integration in taxonomy of the most advanced genomics and bioinformatics techniques, taking into account also the holobiont concept (Serra et al., 2019): we named this approach Next Generation Taxonomy. NGTax will explore and expand this rationale establishing an international and inter-sectoral network of organisations across the EU, Africa, China and Russia. The consortium will work on a joint research programme in Next Generation Taxonomy of ciliates and their symbionts, constituting a holobiontic unit. The proposed approach is strongly multidisciplinary including classical morphological analyses, ultrastructure, molecular tools, genomics and bioinformatics. NGTax will pursue six central objectives: i) validate the NGTax approach on many holobiont systems from different ciliate Classes; ii) contribute rejuvenating taxonomic discipline to ensure traditional expertise is not lost but complemented with state of the art sequencing technologies; iii) consolidate and disseminate the NGTax approach to perform the characterization of eukaryotic organisms to let it become a “new reference standard”; iv) train staff members in NGTax, in order to outline novel scientific positions, boost their careers and import/export useful know-how across sectors, disciplines and countries; v) provide advanced training to male and female researches, including researchers from cultural and religious minorities, from developing countries in order to contribute to boost their academic careers and their integration in international collaborative research networks; vi) support European companies in performing know-how exchange with academic sector, developing new services, and creating new interaction with developing countries.

Keywords: integrative taxonomy,ciliophora,ciliates,bacterial symbiont,comparative genomics,holobiont,microbiome,symbiosis,phylogeny,systematics,morphology,ultrastructure
A complex educational tool based on the power of music, dedicated to preparing children for the challenges of the future by supporting global educational and therapeutic systems. (Musicon BAND)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aim of M company is to remove barriers in education and to prepare children from the earliest age for challenges of the future. The company achieves this by delivering a set of tools for holistic education that uses the most universal language – music. The innovative, globally awarded Musicon educational machine for kids and its accompanying methodology (Musicon BAND), is the first analogue programming tool that uses music. The project has been awarded in the largest world competitions both for design and educational approach. Musicon’s operation and effectiveness has been confirmed by thousands of children and educational institutions as part of a pilot program in Poland and abroad. Some of the project objectives are: level opportunities by providing solutions of educational and therapeutic tools that teach composing and programming without the use of screens; Provide tools for therapeutic work supporting psychomotor development in order to compensate for cognitive and socio-emotional deficits of children; Lift barriers in music education. It’s necessary to provide educational tools that teach holistically to prepare children for changes of the structure of future professions. The Council of EU agrees that “Education and training systems (...) have a fundamental role to play in developing creative and innovative capacities from an early age as key factors in enhancing future economic competitiveness and employability”. M Company is prepared to fulfill above ambitions and is prepared to do so thanks to the team with all required competitions and with a broad experience in product design and sustainable tech.

Keywords: therapy,pre primary education,autism
The first indoor grow light control solution to optimise photosynthetic processes in plants by dramatically cutting energy costs (FarMind)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Estonia
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 3424442.5
EU funding (EUR): 2397109.75
Participants: 1
Project status: SIGNED

At Laava Tech, we are determined to make vertical farming a profitable and sustainable business to feed the increasing population in growing urban areas. It is crucial for vertical farmers to save energy and cut down on lighting costs, since the vast majority of their revenues are used to pay the electricity bill. As a result, only very few vertical farms are profitable today. Our solution, FarMind is an entirely new LED Grow Light System based on AI, capable of adjusting the light emitted by each LED light of a farm to match the exact needs of the plant lit underneath. FarMind reduces the lighting energy bill of vertical farms by up to 75% (vs LED grow lights), whilst increasing crop yields by up to 20%. Unlike other LED grow light technologies, which focus on light efficiency and crop optimisation, FarMind focuses on the real photosynthetic need of the plant. FarMind will revolutionise the vertical farming industry by vastly increasing its profitability. We will provide a drop-in solution, compatible with the existing infrastructure for our customers, indoor farmers. Our main revenue model will be based on providing FarMind as a service to leading farms. Our model will not only allow farmers continued access to the best technology, but also give them an immediate return on investment. Thanks to FarMind, vertical farming will be able to overcome its final growing pain to transition from niche solution to leading urban supplier of sustainably produced fruit and vegetables.

Keywords: indoor farming
Game theoretic Control for Complex Systems of Systems (COSMOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1499415.0
EU funding (EUR): 1499415.0
Participants: 1
Project status: SIGNED

Modern society is based on large-scale, interconnected, complex infrastructures, e.g. power, transportation and communication systems, with network structure and interacting subsystems controlled by autonomous components and human users, generically called “agents”. These systems possess the features of “complex” systems of systems (C-SoS), such as rationality and autonomy of the agents, and require effective multi-agent coordination and control actions for their safe and efficient operation. Multi-agent optimization has attracted an extraordinary amount of research attention as a methodology to let agents cooperatively coordinate their actions, but it is inappropriate and ineffective for systems with noncooperative (selfish) agents, virtually all modern C-SoS. A paradigm shift is necessary to ensure safe and efficient operation of complex systems with possibly noncooperative agents. With this aim, COSMOS shall embrace dynamic game theory and pursue a twofold scientific and technical objective: 1) to conceive a unifying framework for the analysis and control of complex, multi-agent, mixed cooperative and noncooperative, systems; 2) to provide automated computational methods for solving coordination, decision and control problems in C-SoS. To achieve these goals, COSMOS will adopt a novel operator-theoretic approach, and integrate methods within and across dynamic game theory, networked multi-agent systems and control, statistical learning, stochastic and mixed-integer optimization.

Keywords: cyber physical systems of systems,distributed control,monotone game theory,scenario approach
Electro-optical polariton router (ElecOpteR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy,Italy
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-10-01
End date: 2019-03-31
Duration (months): 18.0
Total project cost (EUR): 149406.0
EU funding (EUR): 117531.0
Participants: 2
Project status: CLOSED

In this proposal we plan to bring to a development stage TRL 3 an electro-optical device working at room temperature and based on polaritons (an hybrid photon-exciton particle) made of 2D perovskites and of an optical surface mode in a Distributed Bragg Reflector waveguide. Such a device could lead to extremely compact and ultrafast electro-optical modulators that can be fully integrated in a microchip to allow for fast signal communications between each peripheral component of a processor. As a matter of fact one of the major bottlenecks in processing speed is caused by retardations and dissipations in the interconnections between the CPU and the memory elements as well as other interconnect functions. Conversion of the electrical signal into an optical one can allow for faster and more efficient processing. Our prototype can allow for switching and routing of guided optical beams via electrical signals using the intrinsic nonlinearities of the hybrid photon-exciton states.

Keywords: exciton polaritons,electro optical switching and routing,optical circuits,surface electromagnetic,waves,perovskites
Widening Sino‐EU policy and research cooperation in Personalised Medicine (SINO-EU-PerMed)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Germany,China,Denmark
Call: Actions in support of the International Consortium for Personalised Medicine (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 2338650.0
EU funding (EUR): 1999250.0
Participants: 6
Project status: SIGNED

Personalised Medicine (PerMed) approaches bring along immense potentials to improve diagnosis and treatment of diseases and prevention strategies by taking into account individuals' geno- and phenotypes, biomedical, life style or environmental data. The International Consortium for Personalised Medicine (ICPerMed) is a member state driven initiative of over 40 international ministries and funding agencies. The European Commission (EC) is an active observer and supports by funding several related projects. ICPerMed aims at aligning efforts in all areas of PerMed by fostering international coordination of research and innovation funding. To support these efforts “Widening Sino‐EU policy and research cooperation in Personalised Medicine” (Sino-EU-PerMed) aims at connecting ICPerMed strategies and activities with relevant Chinese stakeholders. To achieve this goal the Sino-EU-PerMed will disseminate and coordinate the following activities. Inventory and analysis of the PerMed landscape in China via a mapping. In addition the Sino-EU-PerMed consortium will exchange expertise and experts by workshops and via delegation trips in China and Europe. Thereby we will gain a better mutual understanding of PerMed activities and related cultural aspects and health economy issues. By establishing technical taskforces and running a series of targeted workshops Sino-EU-PerMed will promote international standards and pave the way for future communication, collaboration and undertakings. Therefore the implementation of a dissemination plan is part of the project. Our consortium and activities aim at maximising the unique and long-term impact PerMed approaches in cooperation and in alignment with ICPerMed. The cooperation with China set up and planned in Sino-EU-PerMed will allow ICPerMed to further strengthen Europe's leading role in this area and contribute to a successful implementation of PerMed in the global context and foster joint PerMed projects between Europe and China.

Keywords: china,icpermed
Remote-Activated Delivery of Therapeutic Exosomes (RADoTE) via an Injectable PEG Hydrogel Carrier (RADoTE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

As a Marie Skłodowska-Curie Fellow, I will develop and demonstrate remote-activated delivery of biological therapeutics loaded into an injectable hydrogel, where delivery is triggered by applying near-infrared (NIR) light that safely and non-invasively penetrates deep into living tissues. The hydrogel carrier will be designed to deliver and stabilize cell-derived exosomes and microvesicles, together referred to as extracellular vesicles (EVs), which have recently gained attention for their ability to effectively deliver biological information and cargo directly to target cells. Developing sophisticated delivery systems for EVs will streamline their translation to clinical application, enabling the huge potential for this novel biological therapeutic to be fully realized. This system will be advantageous in simultaneously providing localized delivery, enhanced EV stability, and crucially, externally triggered release. This project will provide the first demonstration of localized and controlled delivery of EVs, with the added novelty of an externally NIR-triggered delivery system. By combining my expertise in designer hydrogel chemistry, the supervision of Prof. Molly Stevens at Imperial College London (ICL) who runs a world-class interdisciplinary biomaterials-focused group, and a secondment with The Technology Partnership (TTP) specializing in technology translation, this project is ideally situated to deliver the highest quality results.

Keywords: extracellular vesicle delivery,injectable poly ethylene glycol hydrogel,near infrared light triggered release,upconversion nanoparticles
Copernicus Evolution and Aplications with Sentinel Enhancements and Land Effluents for Shores and Seas (CEASELESS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Evolution of Copernicus services (H2020-EO-2016, 2016)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 1999332.5
EU funding (EUR): 1999332.5
Participants: 11
Project status: CLOSED

The CEASELESS project will demonstrate how the new Sentinel measurements can support the development of a coastal dimension in Copernicus by providing an unprecedented level of resolution/ accuracy/continuity with respect to present products. The retrieval and validation for restricted domains and for an enlarged set of combined variables (user oriented) will be the basis to advance the state of the art in assimilation, modelling and applications, at a level commensurate with the new Sentinel capabilities. The project will address the multiple scales coexisting in littoral areas by developing new shallow water parameterizations, introducing them into coupled model suites (wind-wave-surge-current-land discharge) and producing new standards for coastal simulations and analyses. The permanent data base, with dynamic repositories, plus the modular structure of the developed models will demonstrate the technical feasibility of a future operational Copernicus coastal service. The set of derived products will be ingested into the users’ work routines, proving the economic feasibility of the Copernicus coastal extension. The level of conflicts in squeezed coastal zones, expected to grow in the face of climate change, will, thus, benefit directly from CEASELESS, establishing tangible contributions for a wide range of economic sectors. The data repositories (accessible via a dedicated portal), regularly updated with the evolving (satellite-derived) bathymetry will facilitate the use/re-use of our high resolution results, supporting a new set of Copernicus coastal applications such as renewable energy, coastal erosion or harbour exploitation. The mutual validation of satellite data, numerical results and in-situ observations will generate reciprocal profit for enhanced competiveness of EU coastal industries where we shall also explore the suitability for cases in 3rd countries, opening new business opportunities for a coastal Copernicus.

Keywords: coastal,sentinel,retrieval,modelling,assimilation,wind,wave,current,land discharge,performance,database,repository,erosion,flooding,renewable energy,aquaculture,harbours,routing
Development of eco-friendly architectural coil coatings for clean buildings and pollution-free air (CleanCoat)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-10-01
End date: 2018-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CleanCoat is a radically new eco-friendly coating designed specifically for metallic exteriors on high-rise buildings. Our success formula is based on a 70%PVDF matrix with embedded TiO2 nanoparticles (innovation) that simultaneously protects the metal against corrosion, keeps the surface clean (photocatalysis) and purifies the air by reducing pollutants (NO¬x and SOx), thereby addressing EU challenges on raw materials, pollution and ozone depletion. Users of our product are specialized coil coaters (end users) and real estate (final users) who have a need for high production efficiency, cost reductions and aesthetic quality. Thanks to CleanCoats’ embedded structure and NIR curing process, production time is reduced by 50%, cost by 30% and production capacity doubled. With a 30 year guaranteed durability, real estate companies will save up to € 100.000 per year on maintenance and cleaning and enjoy a high quality aesthetic look by the self-cleaning surface, unlimited choice of colours and finishes, and outstanding colour retention and UV stability of the product.

Keywords: coal,coating,photocatalytic,self cleaning,near infrared oven
Finding unknown endocrine disrupting compounds through target pull-down assay filtration, effect direct analysis and ultra-high resolution mass spectrometry for a comprehensive efficient workflow. (PullEd-MS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Czechia,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2022-10-31
Duration (months): 36.0
Total project cost (EUR): 242521.68
EU funding (EUR): 242521.68
Participants: 2
Project status: CLOSED

There are thousands of anthropogenic compounds in general use across the globe and every year more chemicals are created. For every compound, that finds its way into the environment multiple degradation compounds can result due to environmental processes. These changes alter the toxicological properties and chemical mobility creating potentially unpredicted effects. Environmental monitoring using effect direct analysis (EDA) to identify toxicological endpoints combined with mass spectrometry (MS) to detect the most abundant active compounds is an established methodology. The latest MS instruments the ultra-high resolution MS (UHRMS) have allowed full scan acquisition to become the cutting edge in the detection and identification of unknown compounds. However, knowing which EDA to apply is still a challenge and when UHRMS scans detect thousands of compounds identifying which compounds caused the toxicological response is a challenge. This MSC proposal aims to develop the use of pull-down assays linked to specific nuclear receptors (NR) such as estrogen receptor α as a filter to bind only those chemicals with an affinity for that specific protein. By then applying only the target specific EDA and fractionation to identify the most bioactive fraction before UHRMS a more focused workflow for compound detection based on effect can be developed. This workflow will be tested using samples of varying complexity including wastewater, sediment, and human biological samples. These workflows will then be tested using water collected from the Global Water Network to identify novel compounds of toxicological effect in the environment and using human urine from pregnant mothers collected from the CELSPAC-TNG cohort for identification of human exposure. In developing this comprehensive methodology, the sample will have specific toxicological effects identified as well as chemical investigation providing a thorough NR specific determination of both known and unknown compounds.

Keywords: non target analysis,environmental exposure,comprehensive analysis