Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Characterization of Organic-rich Shales using Vapour Adsorption (ACOSVA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The overarching goal of this proposal is to develop a novel experimental framework for quantifying the total specific surface area of organic matter and the wettability of pores in shales, and interpreting the displacement mechanism between gas and water by using a selective adsorption approach coupled with independent verified electron microscope measurements. The overarching goal of the project will be achieved through the following scientific objectives. First, a 3D structural model of the hydrophobic and hydrophilic site distribution in shales at around 50 nm resolution by combining FIB-SEM and high resolution TEM will be developed. This will provide an independent verification for later site-selective adsorption studies. Second, a vapour adsorption method by researching and verifying the most suitable probing vapours and the most reliable measuring approach will be developed. This will create a novel experimental framework for quantifying the total specific surface area of organic matter and the wettability of pores in shales, which will be verified by a previously-built 3D structural model. Last, the displacement mechanism between water and gas will be disclosed by determining the influence of hydrophobic and hydrophilic sites in shales using sequential adsorption and in situ NMR. This will be the essential theoretical part of the work for developing next generation enhanced gas recovery techniques through non-aqueous fluid injection and heat stimulation. The outputs of this project will disclose the chemical/wetting nature of pore systems in shales, which will be essential for improving current fluid transport models in shales by considering surface chemistry properties and developing the next generation of environmentally-friendly shale gas recovery technology through non-aqueous fluid injection and heat stimulation in order to serve shale gas development in the EU, U.S. and China.
The Electron as a Catalyst (e-Cat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: CLOSED

Is the electron a catalyst in synthesis? This fundamental question will be addressed within the frame of the suggested ERC-project. Brönsted acid catalysis is well established in organic synthesis. The electron, as compared to the proton about 1800 times smaller and omnipresent, is currently not recognized as a potential catalyst in synthesis. The concept of using the electron as a catalyst is nearly unexplored. In the suggested, challenging project this kind of catalysis and its potential in synthesis will be the target of the investigations. The aim is to establish catalysis with the electron as an independent research branch in organic synthesis. To this end, the generality and broad applicability of the concept has to be documented. Different reactions, which are currently conducted as non-chain reactions by using transition metals as redox catalysts, will be performed via electron-catalyzed radical chain processes. In view of the foreseen shortage of transition metals we consider the development of transition-metal-free chemistry as important. Guided by Mother Nature we plan to develop synthetic dehydrogenases. Unactivated aliphatic sites in complex substrates will be selectively oxidized to the corresponding alkenes. Remote regioselective C-H functionalization in complex molecules comprising C-C- and C-X-bond formation will be investigated and also transition-metal-free radical arene and alkene C-H functionalization will be explored. Furthermore, the potential of electron-catalysis in asymmetric synthesis will be elucidated. Preparative and kinetic experimental studies will be supported by theoretical chemistry, new methods for initiation of electron-catalyzed processes will be developed and also mechanistic studies will be performed.

Keywords: radical chemistry
Financing Affordable Housing Under Localism (REINVEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-08-15
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project explores the urban governance challenge of motivating institutional investment in affordable rental housing for low-middle income households. The high pressure rental markets of US and European urban financial centres, New York, Amsterdam and London, provide sites for the study. The proposers' prior approach to studying hybrid strategies balancing social and commercial aims in housing organizations is extended to institutional investment. This takes us beyond existing studies of financial incentive structures in institutional investment by recognizing the conflicting logics of profit and affordability, and the potential balancing role of localism. Work Package 1 reviews US experience of innovation to attract institutional investment through tax credit incentives and community reinvestment regulation; and uses stakeholder interviews in two European urban centres to identify key local contextual factors and case study sites. Theories of corporate social responsibility, both discretionary and negotiated, are used to develop an evaluation framework for institutionally-funded affordable housing projects. Work Package 2 explores the negotiation and terms of a sample of case study projects using a structured evaluation methodology. Interviews with investors, policymakers and civic stakeholders reveal actor interpretations of governance arrangements that help connect these projects to finance. Investment decisions are related back to the internal logics and structures of investors and to external incentive structures. Governance models are assessed, drawing on concepts of power and legitimacy. Work Package 3 harnesses a partnership with CECODHAS; the leading European social housing umbrella, to convene an expert panel to apply case study findings to European contexts and to achieve impacts beyond the case study settings. This will help to uncover the potential for urban policy to empower civic actors to negotiate finance for local affordable housing projects.

Keywords: affordable rented housing,governance,institutional investment,localism,corporate social responsibility,decision making,legitimacy,regulation
CP symmetries in rare decays of beauty mesons (ASymmetryNamedCP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

In the recent years, measurements of rare B decays involving b->sll transitions have shown discrepancies compared to predictions of the Standard Model of Particle Physics. These transitions are flavor-changing neutral currents (FCNC): they are forbidden at tree level in the SM and therefore sensitive to contributions of new particles in loops. Global fits to these data suggest new physics contributions that can be explained new physics models involving a tree-level exchange of a lepto-quark or a flavor changing $Z^\prime$ boson. In the decay of neutral Bs meson to a CP eigenstate, the interference between the decay and the B-meson mixing leads to additional observables that are not accessible to flavor specific final states. In the SM, all CP-violating effects are expected to be very small, therefore these observables can make powerful contributions to our understanding of the B-anomalies as they can differ significantly depending on the properties of new physics contributions. This project will measureme the CP violating observables arising in the interference of the decay and mixing of Bs mesons using a tagged analysis for the first time in phimumu decays using full LHCb data set which corresponds to 9 inverse-fb. Additionally a new method to calibrate decay time resolution at LHCb will be developed and tested on run 1-2 data collected at LHCb and will be ready to use for the run 3 which is expected to start at the end of 2021.

Keywords: lhcb cpv b anomalies time dependent decay time time resolution rare decays flavor physics
Loss of chromosome Y in immune cells: targeting disease mechanisms and tools for clinical applications (HEARTLY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1999982.0
EU funding (EUR): 1999982.0
Participants: 1
Project status: SIGNED

Men live shorter and are more susceptible to several common diseases at younger ages compared with women, but the reason(s) why are not well understood. Loss of chromosome Y (LOY) is a male specific mutation that could help explain this sex bias. Men with LOY carry a fraction of blood cells without the Y chromosome, due to its loss from progenitor cells during life time. The incidence of LOY increases with age and can be detected in blood among 40% of 70 year old men. My recent results show that LOY in blood is strongly associated with increased risk for all-cause mortality and disease such as cancer and Alzheimer’s disease, and possibly cardiovascular disease. The causal link(s) behind reproducible associations between LOY in blood and disease are yet to be discovered. My proposal aims for comprehensive understanding of the cellular changes induced by LOY in immune cells and delineation of associated disease mechanisms that could explain why men with LOY in the immune cells of blood have a higher risk for disease in other organs. To this end, several complementary studies are conceived in three synergistic objectives: 1) functional consequences of LOY in immune cells; 2) epidemiological studies of 570.000 subjects with focus on LOY and risk for cardiovascular disease; and 3) development of new tools for LOY-detection. My long-term goal is increased survival of men by utilization of LOY-based clinical applications. For example, men with LOY in blood have on average a higher risk for lethal disease compared with unaffected men. Hence, screening men with LOY for early symptoms of disease could result in earlier diagnoses and treatment using existing health care options. Furthermore, understanding of detrimental effects from LOY on immune system functions could be a key to improved success rates in immunotherapy as well as for identification of new drug targets. Taken together, the project will benefit patients, health care systems and societies at large.

Keywords: loss of chromosome y,mosaicism,mosaic loss of chromosome y,cardiovascular disease,heart diseases,cancer,alzheimer s disease,biomarker,diagnostics,treatment
Breakthrough solutions for adaptable envelopes for building refurbishment (BRESAER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Israel,Spain,Spain,Spain,Spain,Italy,Türkiye,Hungary,Belgium,Greece,France,Netherlands
Call: Adaptable envelopes integrated in building refurbishment projects (H2020-EeB-2014, 2014)
Start date: 2015-02-01
End date: 2019-07-31
Duration (months): 54.0
Total project cost (EUR): 5849107.0
EU funding (EUR): 5849107.0
Participants: 22
Project status: CLOSED

The overall objective of BRESAER project is to design, develop and demonstrate an innovative, cost-effective, adaptable and industrialized envelope system for buildings refurbishment including combined active and passive pre-fabricated solutions integrated in a versatile lightweight structural mesh: ‒ Dynamic window with automatic and controlled air-tightness and insulated solar blinds complementing energy saving and visual comfort strategies, such as light redirection and response to solar radiation ‒ Multifunctional and multilayer insulation panels made of Ultra High Performance Fibre Reinforced Concrete to be used as rigid shells integrating an insulation material ‒ Combined solar thermal air and PV envelope component for indoor space heating and ventilation, thermal insulation and electricity generation ‒ Multifunctional lightweight ventilated façade module ‒ BIPV and Combined thermo-reflexive (improving fire resistance) and self-cleaning coating (through photo-catalytic nanoparticles) The building will be governed by an innovative BEMS covering a specific control system for governing the envelope, the energy use of the building and the strategies for the electrical energy storage. A real demonstration will be performed in an education building in Turkey. Four additional virtual demonstrations will be done in using real building in other European countries covering complementary climatic zones, constructed before the EPBD requirements were enacted. Expected impact: ‒ Energy demand reduction for space heating and cooling 30,7% due to envelope refurbishment ‒ Contribution solar thermal for space conditioning of 37,3% ‒ Contribution of RES for electricity of 12,8% ‒ The combination gives a total primary energy consumption reduction of 76,4% ‒ Improved indoor environment quality by improving thermal, acoustics, illumination comfort and IAQ by reducing VOCs ‒ Provide solutions with a pay-back time below 7 years ‒ Validation and market uptake of active building elemen

Keywords: energy efficiency buildings envelope
Boosting productivity and performance in drug discovery with SEQUOIA - Semantic Query of Information Assets (SEQUOIA-DD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-09-01
End date: 2017-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Synapse Information (UK) have developed a novel semantic web technology, SEQUOIA – Semantic Query of Information Assets – allowing users to rapidly question > 100 disparate data assets in a code-free spreadsheet environment. Having proved the core platform functionality within the financial sector, Synapse now seek to apply SEQUOIA to the field of drug discovery R&D. New drugs are required urgently to treat cancers & other rare/neurological diseases. However, costs and timescales of drug development are huge due to high failure rates. A principle barrier is the lack of real time comparison of disparate datasets, which can identify causal correlations behind reactions throughout the R&D process. Building on the prototype kernel solution, SEQUOIA targets the many high performance silos of public online drug R&D data, enabling all researchers to semantically probe these ontologies against internal R&D. Synapse therefore aim to catalyse a strategic 10 - 100× productivity gain during the discovery phase to disrupt the €5.5 billion/yr drug discovery software market. The overall project aims to: fulfil the further technical developments required to transfer SEQUOIA into priority sectors within drug R&D; initiate the technical and commercial partnerships with key stakeholders in the pharmaceutical industry; validate performance through extended field trials; establish regulatory compliance; deliver compatibility with key user data environments; and optimise a developed product. The proposed Phase 1 feasibility study seeks to address these requirements through: delivery of an elaborated business plan; prioritised EU market entry strategy; analysis of market-held data assets, technical development roadmap; engagement of key stakeholders in the pharmaceutical industry; supply chain initiation; development of IP strategy and value model; as well as regulatory and legal roadmaps for the final phase of developments and exploitation.

Keywords: semantic web,semantic queries,drug discovery software,cloud software,ontologies,semantic query engine,medical analytics,big data
Synthetic Peptidic Nanovesicles for Targeting Paediatric Brain tumours (SPeNTa-Brain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Brain tumours are the most common solid tumours in children, accounting for about 25% of all primary paediatric tumours. The situation is particularly critical for the deadliest brain tumour: glioma, being the leading cause of cancer-related death in children. The main bottleneck for the treatment of central nervous system (CNS) pathologies, including brain tumours (at early stages), as well as brain metastases, lies in the difficulty to cross the blood brain barrier (BBB). In this proposal, I aim to overcome such limitation with the use of super-selective targeted and fully biodegradable polypeptide-based polymersomes, carrying relevant drug combinations for the treatment of paediatric glioma. I propose a step-wise and bottom-up approach to synthesise biodegradable polymersomes from amphiphilic block-polypeptides obtained via the scalable and reproducible methodology of Ring Opening Polymerisation (ROP) of N-Carboxyanhydrides (NCAs). The polypeptide amphiphiles are expected to self-assemble in aqueous solutions yielding nanometric vesicles. These synthetic vesicles will be functionalised with selected BBB receptor ligands in order to approach the super-selectivity concept aiming for active targeting and transcytosis to the brain acting as the so-called “Trojan Horses”. Finally, the super-selective nanovesicles will be loaded with synergistic and clinically relevant combination therapy using anticancer agents and immuno-modulators in order to approach paediatric glioma treatment. I will join for the first time, the use of fully biodegradable polymersomes based on polypeptides, super-selective binding strategies for BBB crossing and the use of chemotherapy+ immunotherapy. Overall, I will develop an innovative therapy, capable of reaching the brain in a non-invasive way, being able to diffuse and target the brain tumour, overcome chemo-resistance and activate the immune system to fight these tumours, being the future end-users, children with incurable cancers.

Keywords: polypeptide amphiphiles,ring opening polymerisation,biodegradable polymersomes,self assembly,super selective targeting,brain delivery,paediatric glioma treatment,combination therapy
Genetic and Molecular Determinants of Spikelet Survival in Cereal Crops (LUSH SPIKE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2021-06-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Meeting the forecasted world demand for food remains a crucial challenge for plant scientists in this century. One promising avenue for improving grain yield of cereal crops, including wheat and barley, involves reducing spikelet mortality. Spikelets, the grain-bearing units of cereal spikes, usually form in excess and subsequently abort during development; increased spikelet survival is linked to increased numbers of grains per spike. Therefore, reducing spikelet mortality is an intriguing approach to improve grain yield. In barley, the number of spikelets per spike at the awn primordium (AP) stage represents the maximum yield potential per spike. After the AP stage, significant spikelet mortality results in fewer grains per spike. Our previous results clearly indicated that spikelet survival in barley is highly genetically controlled (broad-sense heritability >0.80) and that the period from AP to tipping represents the most critical pre-anthesis phase related to spikelet reduction and grain yield per spike. However, the underlying genetic and molecular determinants of spikelet survival remain to be discovered. I therefore propose this ambitious research program with an emphasis on using available genetic resources. Our specific aims during the LUSH SPIKE project are to: (i) discover quantitative trait loci (QTL) for spikelet survival and grain number per spike and validate these QTL in bi-parental doubled-haploid mapping populations, (ii) isolate and functionally characterize Mendelized QTL using a map-based approach, (iii) reveal gene regulatory networks determining spikelet survival during the critical spike growth period from AP to heading, and (iv) elucidate spatio-temporal patterns of metabolite and phytohormone distributions in spike and spikelet sections during the critical growth period, using mass spectrometric imaging. The results we obtain will advance our understanding of how to improve yields of cereal crops.

Keywords: crop yield potential,barley,wheat,fertility