Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Confidence in behaviour changes through serious games (e-Confidence)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Spain,Germany,Spain,Croatia,Belgium
Call: Gaming and gamification (H2020-ICT-2016-1, 2016)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 1151497.5
EU funding (EUR): 999541.88
Participants: 7
Project status: CLOSED

Serious Games have become a popular tool for knowledge transfer, behavioural, perceptual or cognitive change, but their effectiveness has been under several studies aiming to answer the question whether they are an effective instrument. The E-Confidence project aims to test a methodology that includes several models, such as the Activity Theory-based Model of Serious Games (ATMSG) for game development methodology combined with Applied Behaviour Analysis (ABA ) and Learning Analytics (LA) in order to be able to design serious games able to promote behavioural changes in the user. E-Confidence will provide new opportunities for tracking and analysing learners behavioural data and interpreting them in an educational meaningful way. Improving the assessment of progress, performance, learning outcomes, game quality and user appreciation. Behaviour analysis might be able to assist game designers in sorting out conceptual and analytical frameworks to improve gamification. E-Confidence will test the methodology with two serious games developed considering behavioural aspects for the Safe use of Internet and Bullying, the games will be tested in different Spanish and English Schools to assess behavioural changes in children. Having an improved understanding of basic principles of behaviour and adopting a more conceptually systematic framework will provide more effective and successful gamification strategies to Game development SMEs and thus provide higher return of investment through time-saving replicable processes.

Keywords: social behaviour,edutation,education,learning analytics
Frailty, disability, depression and cognitive impairment in ageing; untangling complex relationships in the older population (AGEING NETWORK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Jorge Luis Borges once wrote that “Everything touches everything”, and in doing so elegantly described both the beauty of graph theory and the multi-factorial experience of human ageing. Graph theory provides a framework for investigating the complex relationships in areas such as interpersonal relationships, electricity networks, and human cell structures. In ageing research, the relationships between the concepts of frailty, disability, depression and cognitive impairment remain poorly understood, and the methods used to understand these relationships are limited by unrealistic assumptions. For example, to measure frailty a number of indicators will be used to create an overall ‘score’, this assumes that what is important is a person’s score, and ignores direct relationships between the indicators (i.e., weight loss is not directly related to exhaustion). Preliminary work suggests this is an assumption that does not reflect the reality of the ageing process. To overcome this limitation, graph theory can be used to develop a more complete representation of relationships between concepts of ageing while still enabling us to identify how specific indicators group together to form constructs important in human ageing such as: frailty, disability, depression and cognitive impairment. Using graph theory, a network model will be built to describe these processes and assess intra-individual differences. The data will come from a community sample that is representative of the Irish population aged 50 and older. The results will be of use to both researchers and clinicians. The model will help researchers develop targeted interventions aimed at preventing adverse health outcomes and an android application will be developed to assist clinicians in their day to day practice of gerontology. If pre-frail people can be identified by GPs or public health nurses then it may be possible to help them before frailty leads to disability and loss of independence.

Keywords: aging,frailty,disability,depression,cognitive impairment,network science,older adults
Laboratory- Based Coded Aperture X-ray Phase-Contrast Imaging (LABCAXPCI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-06-01
End date: 2017-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Aim of the LaBCAXPCI project is to make X-ray Phase-Contrast Imaging techniques more powerful and flexible, completing their translation into real-life applications with the deployment of new experimental methods that are fully compatible with a laboratory, industrial or clinical environment. Proof of principle experiments [1] have recently demonstrated that Coded Aperture system are capable of quantitative X-ray Phase-Contrast Imaging with practically no coherence conditions, opening the possibility for the full translation of the high potential of X-ray Phase-Contrast Imaging (i.e. high-magnification imaging, imaging with phase sensitivity in two orthogonal directions simultaneously, dark-field imaging and fully three-dimensional imaging). The completion of LaBCAXPCI will ultimately enable the delivery of better images to a number of people as large as possible. X-ray Phase-Contrast Imaging has a wide range of applications in medicine, biology and material science [2- 6]. Examples of applications that will take advantage of the completion of LaBCAXPCI are: non-destructive testing [7-9], homeland security [10], small animal imaging [11-14], non-calcified tissue [15,16] and breast imaging [17,18]. [1] P. R.T. Munro et al, PNAS 109 (35):13922; [2] T. J. Davis et al, Nature 373, 595; [3] S. W. Wilkins et al, Nature 384, 335; [4] R. Fitzgerald, Physics Today 53(7), 23; [5] F. Pfeiffer et al, Nature Physics 2, 258; [6] R A Lewis, Phys Med Biol 49 3573; [7] B. Zoofan et al, J. Appl. Phys. 100, 014502; [8] S. C. Mayo et al, Materials 5(5), 937; [9] A. W. Stevenson et al, NIM B, 99:427; [10] A. Olivo et al, NIM A, 610, 604; [11] P. Coan et al, Phys. Med. Biol. 55 7649; [12] A. Momose et al, Radiology 217(2):593; [13] T. Takeda et al, Circulation 105:1708; [14] M. J. Kitchen et al, Eur J Radiol 68 (3), S49; [15] P. Coan et al, Invest Radiol 45(7):437; [16] J Li et al, J Anat 202(5):463; [17] Arfelli et al, Radiology 215:1,286; [18] E. Castelli et al, Radiology 259:3

Keywords: p116 metrology and measurement,p320 medical physics,g314 medical engineering and technology,p108 optics and quantum optics
Investigation of the cross-talk between innate and adaptive immunity (X-TALK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The vertebrate immune system has long been considered as a bipartite entity encompassing two independent and isolated arms: innate immunity, providing the first line of defense, and adaptive immunity, responsible for memory. Recent evidence suggests that, in addition to their undisputed role in innate immunity, natural killer (NK) cells and plasmacytoid dendritic cells (pDCs) are important contributors to adaptive immune responses. Yet the mechanisms underlying these cellular interactions are still obscure. Lately, we could demonstrate a key role for NK cells in the initiation of adaptive immunity by describing a novel pathway harnessing NK cell cytotoxicity for robust T and B cell priming. Interestingly, this sterile inflammatory response was found to be entirely abrogated in mice lacking Toll like receptor (TLR) signaling. As TLRs also sense commensal bacteria, we propose to use germ-free mice to address the role of the normal flora in this sterile pathway induced by NK cells (Aim 1). Using a new mouse model allowing unbiased assessment of plasmacytoid dendritic cell (pDC) function, we have preliminary data suggesting that in sterile conditions pDCs negatively modulate NK cells and the subsequent priming of adaptive immune effectors. In apparent conflict with these findings, we observed that pDC deficiency in a model of chronic virus infection leads to defective priming of T cells. Such reduced T cell response was preceded by a substantial decrease in cytokine production, most likely as a consequence of diminished NK cell activity. We want to mechanistically address these unexpected and opposite outcomes that are possibly contingent on the nature of the inflammatory environment (Aim 2). Therefore, by providing a deeper insight into the routes of communication used by effectors of the innate and adaptive immunity, our investigation may reveal novel strategies for the immune–modulation of infections, tumor surveillance or autoimmune diseases.

Keywords: l601innate immunity,l602 adaptive immunity,l604 immunosignalling,l605 immunological memory and tolerance,l603 phagocytosis and cellular immunity,l611 prevention and treatment of infection by pathogen
Dynamic protein interaction networks in cancer (ONCOPROTNET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The inappropriate activity of signaling pathways and activation of gene-expression programs is a primary driver of transformation in cancer cells. In turn, dis-regulation of signaling pathways in cancer cells is frequently caused by mutations in important oncoproteins, which may alter protein expression, structure or function. In addition, increasing evidence shows that oncoprotein mutations may alter the interactions of oncoproteins with other proteins, causing wide-spread perturbations to the network of proteins in the cell. Although high-throughput sequencing techniques are rapidly identifying large volumes of mutations from tumor samples, our understanding of how these mutations transform cancer cells, and more specifically how they perturb protein-protein interactions is lagging behind. This proposal describes novel proteomics and computational techniques directed at understanding how mutations in important oncoproteins disrupt or alter protein-protein interactions, and how these alterations lead in turn to dis-regulation of signaling pathways and gene-expression programs. The work described here focuses on oncoproteins in the Wnt signaling pathway, but importantly, the techniques described are widely applicable, and have the potential to provide a powerful means of elucidating protein interaction networks in cancer cells. The broader impacts of this work include the potential identification of novel colorectal cancer therapeutic targets as well as mapping protein networks in cancer cells, so that in future the wider effects of therapeutics in the cancer cell can be better understood.

Keywords: l203 proteomics,l210 bioinformatics,l213 systems biology,l406 cancer and its biological basis,protein-protein interaction networks,wnt signaling
Overcoming translational barriers to gene therapy by novel vector design (RETINAL-GENE-THERAPY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-05-01
End date: 2017-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Inherited retinal degenerations are a primary clinical focus of adeno-associated virus (AAV) mediated gene therapy. These diseases mostly involve pathogenic mutations in the retinal pigment epithelium or photoreceptor transcripts leading to cell death and progressively lead to blindness. Current delivery methods are efficient for gene delivery to these cells as well as other therapeutically relevant cell types in the mouse retina. However the applicability of these vectors in human gene therapy depends on our ability to overcome the translational challenges between the mouse and human retinas. Naturally occuring AAVs efficient in transducing the mouse retina in most cases lead to insufficient expression in the primate retina due to interspecies differences in the patterns of transduction by AAV. To address the need for more performant AAVs for retinal gene delivery, we developed artificial AAV variants that have superior tranduction properties to the naturally occuring ones in the mouse retina. A resulting novel AAV variant mediated widespread gene delivery to the outer retina when injected into the vitreous in mice and in some areas of the primate retina. We would like to evaluate the therapeutic potential of this and other AAV variants based on this vector in the context of the primate retina. Our aim is to find suitable variants for application in three different gene therapy settings: gene replacement therapies aimed at the outer retina, trophic factor secretion by overexpression of neurotrophin genes and delivery of optogenetic tools to restrore light sensitivity to blind retinas after loss of vision.

Keywords: l705 gene therapy - stem cell therapy - regenerative medicine
Single cell analysis of tumor cells for personalized cancer vaccines (SCA4PCV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Personalized cancer vaccines are therapeutic vaccines custom tailored to target tumor-specific mutations unique to a given patient. Such a treatment offers great hope for cancer patients as it does not harm healthy cells and has the potential to provide life-long remission. The emerging view of cancer as a dynamic evolutionary process that produces startling genetic heterogeneity and escapes treatment poses challenges for cancer vaccines. Yet progress in elucidating the nature of tumor heterogeneity has been impeded by experimental challenges, and the impact on vaccine design has not been investigated. The comprehensive research agenda outlined in this proposal aims to investigate tumor heterogeneity at the single cell level using novel experimental and theoretical methods with the end goal of maximizing the efficacy of personalized cancer vaccines. To accomplish these goals, I will first develop cost-effective high-throughput methods to measure the “mutanome” of hundreds of single cancer cells, integrating next-generation sequencing with microfluidics. Next, novel lineage treeing algorithms will be developed to reconstruct the evolutionary history of the cancer. I will then systematically apply this method to murine and human tumors and thus shed new light on cancer heterogeneity and evolution, reveal driver mutations with unprecedented resolution, enable the design of highly potent cancer vaccines and pave the way for new diagnostic tools. This proposal fits well within the scope of research conducted by the host institute, which aims to develop fundamentally new individualized cancer immunotherapies, with the first personalized cancer vaccines entering clinical trials in the near future. The host institute therefore has the experience and the resources to support this proposal and maximize its translational impact.
Coding for Multi-User Channels for Next Generation Wireless Networks (CODING FOR NETWORKS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

An important component of future information technology applications for various purposes is wireless networking. Addressing interference interference in an optimal manner if of utmost importance to design, implement and deploy reliable wireless networks. In current systems, interference is usually avoided by utilizing suitable networking protocols or it is controlled to be below an acceptable level. On the other hand, neither of these two approaches are optimal, and a different way to solve the problem of handling the interference is needed. The proposed research aims to develop explicit coding and modulation schemes to provide a reliable and efficient physical layer for future wireless networks. In particular, coding for the wireless interference channel and the two-way relay channel as building blocks of efficient wireless networks are of interest. The proposed work will 1) develop efficient coding and modulation schemes for the Gaussian interference channel as well as fading interference channels; 2) jointly design channel codes and for two-way relay channels and consider multi-input multi-output (MIMO) as well as fading channel extensions; 3) develop near optimal short block length codes for the interference and two-way relay channels. The proposed work will be of high impact as it is expected to be an integral component of the physical layer needed in order to build future wireless networks with high transmission rate and reliability requirements.

Keywords: wireless networks,fading channels,channel coding,multi-user systems,interference channel,relay channel,information theory,coding/modulation,ldpc codes,turbo codes
From Structures to Predictions: Precision Multi-jet QCD for LHC Physics (PMJ-QCD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

With the start of the Large Hadron Collider (LHC) at CERN a new era of research of the fundamental laws of Nature has begun. Discoveries, such as Dark Matter particles, the Higgs boson and a refined Standard Model of Particle Physics (SM) will be the backbone for fundamental research in many areas of physics for years to come. The proposed research contributes to this quest. We will provide precision theory predictions for the proton-proton scattering processes, thereby enhancing the discovery reach of the LHC experiments. The interpretation of the experimenters' data requires the comparison to such theory predictions. In the absence of such predictions, new physics signals may remain hidden, or backgrounds may be falsely identified as exciting new physics. More concretely, we will make available precision simulations of the SM and, possibly, an extension thereof. We focus on scattering processes with many final-state objects. These processes are part of the new physics territory unlocked by the LHC and are a key to exploring new fundamental particles and phenomena. The targeted precision requires the computation of at least next-to-leading-order quantum effects within perturbative quantum-field theories. State-of-the-art physics studies, such as the production of tops, the Higgs boson, Z/W-bosons in association with jets, will kick start this research program. The research methodology will be to exploit mathematical structures of scattering processes in order to resolve present computational bottlenecks. The seeds of a new methodology to deal with the complexity of scattering processes has appeared only recently. In fact, key advances go back to a string inspired approach to scattering amplitudes by E. Witten and, most recently, by N. Arkani-Hamed. Such methods have already allowed us to obtain new state-of-the-art results for the LHC experimenters with up to six final state objects including quantum corrections.

Keywords: p101 fundamental interactions and fields,p102 particle physics
Primary Biliary Cirrhosis-Translating genetic discovery into patient benefit (PBCTRAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Primary biliary cirrhosis (PBC) is the most prevalent of adult autoimmune liver diseases, seen in both genders and all ethnicities, but remains without rational treatment. Its immune mediated liver injury is driven by interacting innate, humoral and cellular pathways, on a strong background of genetic and environmental risk. Improved treatment is a priority for patients but is hindered by a) complexity inherent to composite genetic and environmental risks; b) inadequate understanding of molecular pathways linking gene signatures to disease and c) challenges associated with personalising and stratifying treatment. We seek to capture the unique and globally recognised strengths of our autoimmune liver disease research programme in Birmingham, to translate our high impact novel genetic risk associations in PBC, to better understanding of pathogenesis, and thereby develop stratified medicine approaches to effective clinical markers and treatment. We will define and profile a cohort of patients with PBC at a molecular level over time; develop rational targets for treatment by laboratory interrogation of the immunoregulatory pathways identified by our own genetic studies; and over the coming years change treatment perspective by bridging biophenotype to clinical practice, utilising novel biomarkers for monitoring and predicting outcome, as well as facilitating targeted personalised treatments.

Keywords: primary biliary cirrhosis,genome wide association,genomics,translational,treatment response