Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Big Data for Catalysis (BigData4Cat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-10-01
End date: 2016-09-30
Duration (months): 12.0
Total project cost (EUR): 149875.0
EU funding (EUR): 149875.0
Participants: 1
Project status: CLOSED

Catalysis is one of the scientific areas in which Europe has a leading position. The radical change in the use of raw materials from oil towards gas or biomass might compromise this position. Computational techniques have been identified as the third pillar in catalysis research and provide a great amount of data that can speed up the generation of new catalytic systems through rational design. Industries are now starting to focus on the large amount of data published in the open literature regarding mechanistic studies so that they can accelerate their discovering of new catalysts. However, the unstructured and unlinked nature of this information hinders a fast transference of published knowledge to the chemical industry. Our BigData4Cat proof of concept would generate a simple, unified platform: ioChem-BD, where all the data regarding atomistic theoretical simulations in catalysis could be stored and retrieved in a structured manner. The platform will highlight the links, establish the relationships between data from different sources, provide error bars, and allow inferring data from missing steps in complex reaction networks. Moreover, it will provide problem-targeted structured databases with data-mining options. The final goal to the project is to transfer the mature computational Chemistry methodology and data into growing research strategies through the ioChem-BD platform. The goal of the proof-of-concept will be to store, structure and search the Catalysis Big Data resources in a sustainable manner that can be adapted to different problems at academic, editorial and industrial levels.

Keywords: catalysis,chemistry,atomistic simulations,density functional theory,big data,homogeneous,heterogeneous,materials science,storage,computational chemistry,sustainability,database,datamining
Dynamic interplay between phosphorylation and ubiquitination during plant receptor kinase-mediated immunity (PHOSPH-UBIQ-IMMUN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-08-17
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The first layer of plant immunity is mediated by the recognition of conserved microbial features known as pathogen-associated molecular patterns (PAMPs) by plasma membrane-localized pattern recognition receptors (PRRs). An immediate downstream substrate of activated PRR complexes is the cytoplasmic kinase BIK1, which is a positive regulator of PAMP-triggered immunity (PTI). The objective of this proposal is to uncover how BIK1 regulates plant immune signalling via the characterization of its substrates in PTI. The host laboratory has recently identified a potential BIK1 phosphorylation motif, which is present in 22 Arabidopsis proteins that are rapidly phosphorylated upon PAMP treatment. Eight of these proteins have been confirmed as true BIK1 phosphorylation substrates and include several proteins involved in protein ubiquitination/deubiquitination, including an E3 ubiquitin ligase and two ubiquitin specific proteases (USPs), which will be the focus of this study. Preliminary data indicate that the E3 ubiquitin ligase is a positive regulator of PTI. Here, I will further characterize the role of this E3 ubiquitin ligase in PTI by characterising the role of its phosphorylation by BIK1, and identifying its substrates and their role in PTI using genetic and biochemical approaches. A similar approach will be used to decipher the role of the two USPs in PTI. The project will directly benefit from my previous experience in working with deubiquitinating enzymes during plant development, which will provide all the necessary technical and theoretical knowledge to ensure the project’s success. This exciting project will allow me resuming my career in science, thus corresponding to the objectives of the People Work Programme. At the end of the project, we will have a better understanding on how activated PRR complexes regulate downstream immune signalling, which is a very important question in innate immunity, in both plants and mammals.

Keywords: innate immunity,pamp triggered immunity,cytoplasmic kinase,signal transduction,phosphorylation,ubiquitination,deubiquitination,sustainable crops
Next Water Governance (NEWAVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Italy,Spain,France,Netherlands,Netherlands,United Kingdom,United Kingdom,Kenya
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-04-30
Duration (months): 54.0
Total project cost (EUR): 4039273.44
EU funding (EUR): 4039273.44
Participants: 10
Project status: SIGNED

The NEWAVE project departs from the notion that the global debate about water governance needs a reset, and aims to point the way forward. It does so by developing research and training for a new generation of future water governance leaders, and by equipping them with the transdisciplinary skills to better tackle water challenges. The central organizing framework in NEWAVE is formed by the “three Ps” – which reflects the insight that future water governance leaders should have a deep and transdisciplinary understanding of 1) Problématiques - the nature of nowadays water challenges; 2) Paradigms – the ideational underpinnings of current approaches to water governance; and 3) Patterns – the way in which newly proposed approaches interact with existing institutions. NEWAVE proposes cutting edge research on all these aspects from a global perspective, a highly sophisticated training program to teach the required skills to analyze these issues in a reflexive way and to come up with recommendations about them, and a close collaboration with several of the most prominent players in the water governance debate. NEWAVE will not only be active in Europe, but will additionally target the water governance debate in a carefully selected number of emerging economies and developing countries, and has the right partners on board to do so. Because of its excellent design, NEWAVE will help to recognize and avoid the traps in the current debate on water governance, such as panacea thinking, the disregard of institutional contexts, and the neglect of politics or normative considerations such as justice and equity. NEWAVE thus presents an opportunity to make a step change in an salient societal debate in Europe, and far beyond, and is designed to leave a strong legacy in terms of networks, insights and skills acquired.

Keywords: water governance,policy change,sustainability challenges
KilonovaRank: gravitational wave counterparts and exotic transients with next-generation surveys (KRANK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom,United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1478343.0
EU funding (EUR): 1161677.0
Participants: 2
Project status: SIGNED

Time-domain astronomy will soon be transformed by powerful instrumentation: the Large Synoptic Survey Telescope (LSST) and upgraded gravitational wave detectors. We will finally be able to build large samples of rare and multi-messenger transients, allowing new scientific breakthroughs. But to do so, we must overcome the substantial difficulty of identifying the important events among an expected sea of contaminants. I will solve this problem by developing novel image classification techniques before LSST begins, and then use this with LSST data to answer some of the most pressing questions about stellar evolution, nucleosynthesis, and high energy physics. I will discover hundreds of superluminous supernovae (SLSNe), key to unknown physics in massive stars, and tidal disruption events (TDEs) of stars around supermassive black holes, probing black hole accretion in usually inaccessible regimes. By folding in the sky maps from GW detections of neutron star mergers, I will rapidly find kilonova counterparts in LSST follow-up searches. With 10-100 kilonovae (compared to 1 well-studied event now), we will understand the nucleosynthesis of all heavy (r-process) elements, determine the equation of state for nuclear matter, and pin down what these mergers leave behind. Moreover, I will determine the progenitor stars and power source of SLSNe, and the emission mechanisms in TDEs and relation to black hole mass, using even larger samples of those events. We may even find whole new transient classes. This project could not be more timely as the upgrades in GW detectors, the start of LSST, and the brief era of JWST will overlap in just a few years (and within the time of an ERC-funded project). Everything is in place for success, from guaranteed data access and follow-up resources, to public/prototype codes. The legacy datasets for rare transient classes will dwarf those from pre-LSST, and our inference framework will lead to an unprecedented understanding of these populations.

Keywords: gravitational waves,kilonova,supernova,transient,time domain,lsst,ligo
Homo Mimeticus: Theory and Criticism (HOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Switzerland,Belgium
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2016-11-01
End date: 2022-04-30
Duration (months): 66.0
Total project cost (EUR): 1044000.0
EU funding (EUR): 937625.0
Participants: 2
Project status: CLOSED

Mimesis is one of the most influential concepts in Western thought. Originally invoked to define humans as the “most imitative” creatures in classical antiquity, mimesis (imitation) has recently been at the centre of theoretical debates in the humanities, social sciences, and the neurosciences concerning the role of “mimicry,” “identification,” “contagion,” and “mirror neurons” in the formation of subjectivity. And yet, despite the growing confirmations that imitation is constitutive of human behaviour, mimesis still tends to be confined to the sphere of realistic representation. The HOM project combines approaches that are usually split in different areas of disciplinary specialization to provide a correction to this tendency. Conceived as a trilogy situated at the crossroads between literary criticism, cinema studies, and critical theory, HOM’s outcomes will result in two monographs and accompanying articles that explore the aesthetic, affective, and conceptual implications of the mimetic faculty. The first, radically reframes a major proponent of anti-mimetic aesthetics in modern literature, Oscar Wilde, by looking back to the classical foundations of theatrical mimesis that inform his corpus; the second considers the material effects of virtual simulation by looking ahead to new digital media via contemporary science-fiction films; and the third establishes an interdisciplinary dialogue between philosophical accounts of mimesis and recent discoveries in the neurosciences. Together, these new perspectives on homo mimeticus reconsider the aesthetic foundations of a major literary author, open up a new line of inquiry in film studies, and steer philosophical debates on mimesis in new interdisciplinary directions.

Keywords: mimesis,english literature,theories of imitation and contagion,critical theory
Standards and Regulations for the Bio-based Industry (STAR4BBI)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Coordination and support actions
Partnership: BBI (Art-187)
Countries involved: Germany,Germany,Netherlands,Netherlands
Call: Standards and regulations (H2020-BBI-PPP-2015-2-1, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 995877.5
EU funding (EUR): 995877.5
Participants: 4
Project status: CLOSED

This project will contribute at establishing a coherent, well-coordinated and favourable regulatory / standardization framework for supporting the development of a cutting edge bio-economy for Europe. More specifically, support to the standardization process for the concrete development of new value chains based on lignocellulosic feedstocks and biomass from forests, from agriculture and from organic waste will be provided. The main objective of the STAR4BBI project is promoting a level playing field for bio-based products. The focus of the project will be on finding practical ways to modify regulations in such a way that alternative wording, product specifications, and/or measuring methods will eliminate hurdles without compromising the initial objectives of the standard or regulation.

Keywords: value chains,waste
Towards a System of Distributional National Accounts (DINA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,United States,United Kingdom
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-03-01
End date: 2026-02-28
Duration (months): 72.0
Total project cost (EUR): 9813903.0
EU funding (EUR): 9813903.0
Participants: 3
Project status: SIGNED

A renovated approach to the measurement of economic inequality consistent with macro aggregates should rebuild the bridges between distributional data available from micro sources and national accounts aggregates in a systematic way. This is the main goal pursued through DINA-Distributional National Accounts. The aim is to provide annual estimates of the distribution of income and wealth using concepts that are consistent with the macroeconomic national accounts. In this way, the analysis of growth and inequality can be carried over in a coherent framework. This endeavour also involves the production of synthetic micro-files (i.e. individual level data that are not necessarily the result of direct observation but rather through estimations that reproduce the observed distribution of the underlying data, including the joint distribution of age, gender, numbers of dependent children, income and wealth between adult individuals) providing information on income and wealth, which will also be made available online. The global aim is to release income and wealth synthetic DINA micro-files for all countries on an annual basis. Such data will certainly play a critical role in the public debate, and will be used as a resource for further analysis by various actors in civil society and in the academic, business and political communities.

Keywords: distribution income wealth inequality national accounts returns
Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage (PRYSM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1499108.0
EU funding (EUR): 1499108.0
Participants: 1
Project status: SIGNED

Intracranial aneurysms usually go undetected until rupture occurs leading to aneurysmal subarachnoid hemorrhage (ASAH), a type of stroke with devastating effects. Early detection and preventive treatment of aneurysms fall short as we do not know who is it at risk and why, as we have insufficient insight in the contribution and interplay of genetic, environmental and intermediate phenotypic risk factors. Given the rarity of the disease, there is a paucity of large and rich cohorts to study risk factors separately with sufficient power. To add to the problem, my preliminary findings suggest disease heterogeneity with subgroup specific risk factors for aneurysms. The sex-related heterogeneity is most eminent in the disease with 2/3 of patients being women. I aim to advance disease understanding to allow early recognition of intracranial aneurysms to prevent ASAH. I have established a new conceptual approach that integrates genetic and environmental risk factors with imaging markers as intermediate phenotypes for genetic factors. With data reduction and machine-learning approaches I will for the first time address disease heterogeneity and aneurysm risk with adequate power. I will develop and validate a tool to automatically detect new imaging markers predicting aneurysm development applying feature-learning models. Next I will elucidate the genetic basis underlying differential imaging risk patterns (imaging genetic factors). I will apply a new hypothesis-free strategy to detect and validate yet unknown environmental risk factors predicting aneurysm presence. I will assess the contribution to disease of all factors detected according to sex. All risk factors will be combined in an aneurysm prediction risk model to understand relative contribution of different risk factors in different subgroups. It will advance disease understanding and individualized risk prediction of aneurysms leading to precision medicine in early aneurysm detection to reduce the burden of ASAH.

Keywords: intracranial aneurysm,aneurysmal subarachnoid hemorrhage,genetic risk factor,environmental risk factor,imaging marker,imaging genetics,risk prediction
Copernicus Academy Hub for Knowledge, Innovation and Outreach (CopHub.AC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Coordination and support actions
Countries involved: Spain,Italy,Italy,Austria,Germany,Cyprus,Belgium,Belgium,Lithuania,Netherlands
Call: Space hubs for Copernicus (H2020-SPACE-2018, 2018)
Start date: 2018-10-01
End date: 2020-12-31
Duration (months): 27.0
Total project cost (EUR): 999966.25
EU funding (EUR): 999966.25
Participants: 12
Project status: CLOSED

The overall objective of CopHub.AC is to create a knowledge and innovation hub with several nodes (secretariat, research briefs, knowledge landscape, outreach, sustainability) to focus and link ongoing R&D activities in Copernicus-relevant academic fields, and to sustain the innovation process from academia to businesses on the highest possible scientific and technical level, with a clear commitment to a full thematic and geographic coverage for a Europe-wide boost in space uptake. The CopHub.AC consortium led by PLUS / Z_GIS will provide the following objectives: i) foster the enlargement of the Copernicus Academy ecosystem through a well-orchestrated set of tools and structures; ii) reinforce the R&I capacities of Copernicus Academies and channel their outputs within an improved format of research briefs; iii) inform industry, educational networks, authorities and the citizen about Copernicus and its societal benefits. iv) promote capacity building of and connectivity with the Copernicus Relays Network; v) promote the long-term impact and sustainability of the Copernicus Academy network through the establishment of a secretariat, a monitoring process and a forward looking roadmap. A duration of 24 months is envisaged. During the second year, the EC will be provided with recommendations for the continuation of the activities under long-term funding.

Keywords: copernicus academy secretariat,knowledge landscape,innovation monitor,user uptake
Electro-motion for the sustainable recovery of high-value nutrients from waste water (E-motion)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-11-01
End date: 2022-10-31
Duration (months): 72.0
Total project cost (EUR): 1950000.0
EU funding (EUR): 1950000.0
Participants: 1
Project status: SIGNED

Current water treatment technologies are mainly aimed to improve the quality of water. High-value nutrients, like nitrate and phosphate ions, often remain present in waste streams. Electro-driven separation processes offer a sustainable way to recover these nutrients. Ion-selective polymer membranes are a strong candidate to achieve selectivity in such processes. The aim of E-motion is to chemically modify porous electrodes with membranes to introduce selectivity in electro-driven separation processes. New, ultrathin ion-selective films will be designed, synthesized and characterized. The films will be made by successively adsorbing polycations and polyanions onto the electrodes. Selectivity will be introduced by the incorporation of ion-selective receptors. The adsorbed multilayer films will be studied in detail regarding their stability, selectivity and transport properties under varying experimental conditions of salinity, pH and applied electrical field, both under adsorption and desorption conditions. The first main challenge is to optimize and to understand the film architecture in terms of 1) stability towards an electrical field, 2) ability to facilitate ion transport. Also the influence of ion charge and ion size on the transport dynamics will be addressed. The focus of E-motion is set on phosphate ions, which is rather complex due to their large size, pH-dependent speciation and the development of phosphate-selective materials. Theoretical modelling of the solubility equilibria and electrical double layers will be pursued to frame the details of the electrosorption of phosphate. E-motion represents a major step forward in the selective recovery of nutrients from water in a cost-effective, chemical-free way at high removal efficiency. The proposed surface modification strategies and the increased understanding of ion transport and ionic interactions in membrane media offer also applications in the areas of batteries, fuel cells and solar fuel devices.

Keywords: physical chemistry,process engineering,separation processes,water treatment,sustainability,polyelectrolytes,ion selectivity,ion recovery