Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Connecting SOLar and stellar Variabilities (SOLVe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 1443000.0
EU funding (EUR): 1443000.0
Participants: 1
Project status: CLOSED

The proposed project aims at answering four general questions of high scientific importance: - How typical is the Sun as active star? - What is the solar role in climate change? - What are the limitations for detectability of Earth-type planets in habitable zones? - Can the solar paradigm help us to explain variability of other stars and to better detect and characterize exoplanets? These exciting questions can now be addressed thanks to recent progress in solar and stellar physics. On the observational side, the unprecedented precision of broadband stellar photometry achieved with the CNES CoRoT and the NASA Kepler satellites initiated a new era in studying stellar photometric variabilities. Recent surveys with ground-based automated telescopes have significantly increased the number of stars observed over their activity cycles. On the theoretical side, solar irradiance models have matured to reproduce solar brightness variability in great detail. The enormous progress in magnetohydrodynamic simulations of solar and stellar atmospheres as well as the development of new computationally efficient radiative transfer schemes makes it finally possible to extend physics-based solar irradiance models to other stars, thus opening an entirely new horizon for solar-stellar and solar-terrestrial connection studies.

Keywords: solar stellar connection,solar terrestrial connection
The ATP-P2X7R axis: a target for drug-refractory epilepsy (EpiPur)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2020-01-12
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Current epilepsy therapies, based on mediating excitation or inhibition have no impact on disease progression and are ineffective in over 30% of patients, demonstrating the urgent need for therapies with different mechanisms of action. An exciting concept is that increased hyperexcitability states and network changes are caused and maintained by a sustained glial activation.The ATP-gated P2X7 receptor (P2X7R), a gatekeeper of inflammation, has recently emerged as a promising target for epilepsy, showing anticonvulsant and disease-modifying properties in animal models. To bring P2X7R further towards a clinical application, however, important gaps in our understanding must be filled. Evidence for ATP release in the brain during seizures is currently lacking, the cell types involved in pathological P2X7R activation must be determined, and whether results from rodent models can be replicated in human tissue must be tested. Recent technical advances now bring the answers to these questions within reach. EpiPur brings together a team of experts in purinergic signalling, industrial partners specialised in the development of P2X7R antagonists and epilepsy clinicians. Biosensors will be used to record ATP in vivo with high sensitivity and temporal resolution; new transgenic mouse lines will be used to elucidate the subcellular expression and cell-specific disease contribution of P2X7R. Newly developed P2X7R antagonists will be tested in brain tissue resected from epilepsy patients. This highly interdisciplinary and intersectoral approach will add a significant contribution to the understanding of neuroinflammatory processes in disorders of the CNS. Further, the skills acquired during the research project, the excellent training record of the supervisor and host institution and the outstanding resources for learning and development available at RCSI will give me the tools necessary to achieve research independence.

Keywords: epilepsy,drug refractory,atp signaling,p2x7 receptor
From light-stimulated anion receptors to transmembrane carriers and pumps (LIGHTPORT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands,Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 1499461.0
EU funding (EUR): 1499461.0
Participants: 2
Project status: SIGNED

The transport of anions across the cell membrane, which is mediated by transport proteins, is essential to many important biological processes. Dysregulation of this transport has been associated to various diseases and therefore, chemists endeavour to develop artificial receptors that mimic the function of natural transporters. Despite much progress over the last decade, the current artificial systems are mostly static, while proteins are able to change their activity dynamically in response to stimuli in the environment. To integrate such stimuli-controlled behavior in synthetic systems is a key contemporary challenge. In view of this, the goal of the proposed research program is to develop anion receptors in which the binding properties can be effectively modulated by light and to apply these receptors as transmembrane carriers and pumps, in order to regulate passive transport (i.e. down a concentration gradient) and to induce active transport (i.e. against a concentration gradient). This interdisciplinary program is divided into three work packages: WP1 aims at the development of structurally rigid and visible-light-actuated photoswitches and their use as platforms for constructing anion receptors; WP2 deals with the development of mechanically interlocked structures as photoswitchable anionic hosts; WP3 is directed at utilizing these receptors for light-gated transport and light-driven pumping of anions across phospholipid bilayers, whereas also an alternative dual-responsive anion channel will be prepared. Eventually, it is expected that this work will open a new route toward light-based localized pharmacological treatment, e.g. via light-triggered cancer or bacterial cell death. Furthermore, active transport systems, that are able to build up and maintain concentration gradients across membranes, could provide a completely new view on how to convert and store light (solar) energy.

Keywords: anion binding,molecular switches,photochromism
Development of a multiple-domain Outbound Metabot (POBUCA Bot)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Greece
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sieben Ltd. is an SME operating in the domestic and international ICT markets since October 2000. A prominent part of the company’s product portfolio includes POBUCA, a Corporate Software suite offering a range of functionalities designed to boost customer sales and productivity. Currently, POBUCA consists of: - POBUCA Connect, which assists organizing and sharing of business contacts, - POBUCA Loyalty, which offers tools for maximisation of customer loyalty, - POBUCA Sales, supporting the sales and delivery value chain end to end. POBUCA has become a Sieben Ltd. success story, with sales both in domestic and international markets, in particular through strategic collaborations with Vodafone and Telefonica. Significant contributor to POBUCA success is considered to be POBUCA Chatbot, i.e. an inbound Virtual Assistant (VA) facilitating interaction between POBUCA and users. More info on POBUCA can be found through http://sieben.gr under “Products”. Taking into account the challenges and opportunities within the Corporate Software ecosystem as well as anticipated ICT market prospects within 5G-IoT era, main objective of POBUCA Bot Project is to disrupt international Corporate Software markets through the transformation of its existing POBUCA Chatbot module into an internationally unique, Outbound Metabot serving multiple domains. Such a development will mark the introduction of Artificial Intelligence (AI) within the Corporate Software environment. Further, successful development of POBUCA Bot, is expected to allow massive deployment in 5G-IoT-related vertical industries, since low-latency communications will need to be assisted by ultra-reliable man-machine communication and user experience (UX) augmenting human capabilities.

Keywords: outbound metabot,5g iot enabled ux
Towards the application of MOrphing MOvables in AEROstructures (AEROMO2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Netherlands,Netherlands
Call: Coupon and element testing and manufacturing of test article for morphing technologies (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-06-01
End date: 2023-07-31
Duration (months): 38.0
Total project cost (EUR): 903925.0
EU funding (EUR): 882475.0
Participants: 3
Project status: SIGNED

The framework of the project is to support the development of an active morphing winglet demonstrator within the Airframe ITD. The current project will deliver elements necessary for the future industrialisation of the technologies involved in morphing movables. These elements concern (I)- a comprehensive material behaviour characterisation and prediction method, specific for the requirements coupled with this application, subsequently called ‘Part A’, (II)- a production method necessary to demonstrate the application of a novel pressurised cell actuation system subsequently called ‘Part B’. Both parts are complementary, though these will support two types of demontrators. The first part is meant to realise a large step towards qualification of the morphing technology on focussing on materials able to realise morphing defomation in an existing concept, while the second one focuses on a technology integrating all aspects related to morphing movables, around an innovative fluid based control system, named FAMoUS.

Keywords: morphing,movables,thermoplastic,fluid actuation,winglet
Topological organization of vertebrate regulatory landscapes: The Hox genes paradigm (RegulHox)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 2499628.0
EU funding (EUR): 2499628.0
Participants: 1
Project status: CLOSED

The aim of this grant is to understand how mammalian developmental genes, which are usually pleiotropic, are controlled via long-range regulations and how chromatin partitions into large and discrete regulatory domains, generally matching Topologically Associating Domains (TADs). We want to understand how such domains emerged in evolution, how they are built during development and how they help implement enhancer functions. We will use a large genomic interval in mouse chromosome 2 containing the HoxD cluster as a paradigm, as it is covered by a large allelic series re-organizing the topology of this interval. Since the syntenic human locus (2q31) is affected in numerous genetic syndromes involving CNVs or large DNA re-arrangements, we believe this work will also help understand the mechanistic bases of human regulatory mutations. The approach will capitalize on our knowledge of mouse embryos, the implementation of cutting-edge genomic technologies and the unique collection of engineered mammalian chromosomes kept into living mice, which represent as many targeted re-organizations of both chromatin and regulatory topologies. It will require important technological development, in order to apply to mammalian embryos, methods (HiC) currently used for cell cultures or adult tissues. We think that the feasibility of this novel program is high, due the portfolio of experimental tools recently developed in our laboratory. Also, pilot experiments have been initiated to identify problems and preliminary results including the use of HiC on embryonic tissues suggest that the proposed experiments can be realized within delay. The novelty and originality of this program are in the interdisciplinary and system approach of genomic re-arrangements, as analyzed in vivo using recently developed methodologies, allowing to associate topological variations with regulatory modalities in a physiological context, during normal or genetically impaired embryonic development.

Keywords: gene regulation,chromatin structure,developmental patterning,mouse genetics
Development of the most advanced audio systems enabling the production of a revolutionary generation of MEMS micro speakers that will be deployed in the world's top mobile applications (MOON-MEMS speaker)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Austria
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

USound develops cutting-edge piezoelectric MEMS technology for providing Micro Electronic-Acoustic devices expanding the functionalities of earphones and headphones, with exceptional audio performance, lean manufacturing flow, miniaturization, simple integration and low power consumption thereby overcoming the limitations of all the existing technologies on the market. USound gains competitive advantage through the collaboration with best in class European scientific and industrial partners, applying the high potential “fabless semiconductor” business model. The underlying technology is based on three main technology blocks: Piezoelectric MEMS, Embedded Component Packaging technology and Standard complementary metal–oxide–semiconductor (CMOS) process and has already reached TRL 6. USound’s first product will be a sub-miniature speaker for in-ear or near-the-ear headphones. Manufacturers face an increasing demand for improved sound quality, for devices with ever more functions and lower power consumption, and a fierce competition within the industry, resulting in decreasing gross margins and selling prices. USound B2B customers will gain competitive advantage through 20% overall cost reduction, low power applications, higher integration, design flexibility and improved sound quality which allow offering devices with new and improved functions. The feasibility study will support final prototyping, validation & demonstration to reach TRL 9 and provides the economic arguments (risk management, IP strategy, Business plan) to ensure further private investments, public funding (e.g. SME phase 2) and boosting the market uptake. With USound technology Europe will have the opportunity to take over a leading role in the field of MEMS technology for the global Micro Electronic-Acoustics market, building up unique knowhow protected by patents and fostering Europe as a high class R&D location with new jobs and high competitiveness towards competition from the US and Asian markets

Keywords: piezoelectric mems audio platform,lean manufacturing flow,cost reduction,miniaturization,simple,integration,excellent acoustic,highly integrated audio products with low power consumption
Peers in ECEC centres: who are they and do they matter? An empirical analysis on ECEC group composition, its drivers and its effects (PEARLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-16
End date: 2020-03-22
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Early childhood education and care (ECEC) services are increasingly seen as holding the promise of promoting more equal life chances for children by supporting their development and encouraging parental employment. Research shows that ECEC can fulfil such potential, as long as provision is of high quality and reaches the most disadvantaged children. Yet there is ample evidence that disadvantaged children are less likely to attend ECEC institutions. When they do, they are enrolled into settings with lower quality and/or settings catering mostly to other children from disadvantaged families. This latter aspect, relating to settings’ composition, is rarely investigated, but the few existing studies suggest that disadvantaged children “do better in settings with a mixture of children from different social backgrounds”. This research project seeks to offer new evidence on the composition of ECEC settings, to explore the drivers of different levels of concentration of disadvantaged children, and to measure the impact of such levels of concentration on child development. The composition of ECEC settings will be measured in relation to migration status, a salient dimension of educational disadvantage in several European countries. The project focuses on the specific case of Germany, where ECEC attendance varies markedly in relation to both socio-economic status and place of residence. The analysis will draw on different data sources, combining survey data on children and the ECEC they attend with information at a highly disaggregate regional level in order to account for the neighbourhood context in which families live. By combining three levels of analysis – families, ECEC settings, and neighbourhoods – the study develops an multilayered approach which will enrich the child development literature on ECEC services as well as our understanding of educational disadvantage. The findings will strengthen evidence-based knowledge in policy making and service provision in Europe.

Keywords: early childhood education and care,peer effects,migration,longitudinal data
Four-dimensional physical modeling and numerical simulation of the early mouse embryo morphogenesis. (MecaMorphEME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The quantitative understanding of the early development of mammalian embryos is essential to the progress of reproductive medicine. Yet, the physical and mechanical principles governing their morphogenesis remain largely unknown. Early mouse embryos self-organize by a succession of cell divisions, deformations and rearrangements, leading ultimately to the specification of two distinct cell lineages, segregated in inside and outside layers. Mechanical forces are therefore as important as biochemical activity in this process and precise 4-dimensional imaging of cells within the embryo reveals intense surface dynamics, regulated by contractile and adhesion proteins. However, our understanding of early embryos development still lacks a precise physical model integrating a dynamic description of the mechanical forces controlling cell shape and cell-cell adhesion. I will design a 4D physical model of the early mouse embryo providing accurate cell dynamics predictions. Cell shapes are primarily controlled by the actomyosin cortex and they will be described using recently developed cortical active shell theories. To represent accurately cell-cell adhesion dynamics, I will consider the crosstalk between cortical and adhesion proteins activities. Importantly, this model will be designed in close collaboration with an experimental group expert in the biophysical characterization of the mouse embryo, to incorporate measured mechanical parameters and molecular regulation mechanisms. Our model will be refined through cycles of theoretical predictions and experimental validations to uncover the principles of early mammalian embryos development and, more specifically, the mechanism of cell internalization at the 8 to 16 cells transition. This interdisciplinary project, at the interface between physical modeling and developmental biology will provide a unique and accurate biophysical framework for understanding the morphogenesis of early mammalian embryos.

Keywords: modeling,simulation,early mouse embryo,morphogenesis,actomyosin cortex,cell cell adhesion,active gels,level set methods