Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Echo Chambers: Online Segregation, Mechanisms, and Consequences (ECHO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1491250.0
EU funding (EUR): 1491250.0
Participants: 1
Project status: SIGNED

The internet and social media dramatically transformed the news landscape. The abundance of online news options, recommendations of social media algorithms, and changes in news production may have segregated individuals into echo chambers, environments where people mostly consume like-minded news. Such echo chambers could exacerbate polarization, distort perceptions of reality, and threaten democracy. However, a gap remains between these grave concerns and the limited evidence on echo chambers. A critical challenge is that research is typically conducted at the outlet level. Focusing on outlets rather than individual articles may underestimate segregation as individuals today consume specific articles from many outlets. This project will analyze the demand and supply of news at the article level to provide new insights regarding the origins, extent, and implications of online echo chambers. The project consists of three parts. First, I will create a new dataset of the slant (political leaning) of millions of articles using high-resolution data, expert ratings, and advances in large language models. I will use this dataset to provide the first estimate of online segregation based on the slant of articles. Second, instead of fixing the set of articles and analyzing consumer behavior, I will fix the audience and analyze how outlets tailor articles to their consumers, and whether this increases segregation. I will complement the descriptive estimates of how outlets distribute news with a casual analysis of whether the internet and social media affect the news that outlets produce. Third, I will elicit individuals’ willingness to pay for various articles and causally estimate how the articles people typically avoid affect their attitudes when they are consumed. I will use these estimates to decompose the relative importance of two theories for how news polarizes attitudes: differences in preference for like-minded news and heterogeneity in the effects of news.

Keywords: echo chambers,online segregation,news avoidance,news demand,news slant,filter bubbles,news consumption
Decoding and perturbing cell identity regulatory network for cell fate and state engineering (DECIPHER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 1799999.0
EU funding (EUR): 1799999.0
Participants: 1
Project status: SIGNED

Human cells engineered in vitro have revolutionized our ability to model human biology and diseases, offering exciting opportunities for therapeutic screening and intervention. However, single-cell transcriptomics (scRNA-seq) reveals that engineered cells often remain heterogeneous, immature, and dissimilar to primary counterparts. Precise cell engineering remains challenging without systematic interrogation of gene regulatory networks (GRNs) that establish cell identity. Here, we propose to engineer precise cell fates and states by coupling GRN decoding, perturbation screening, and single-cell technologies. Our vision is to decode GRNs that shape cell identities in fate specification, multicellular communication, and maturation, and use this insight to 1) engineer precise cell subtypes, 2) reconstruct niche-specific signatures, and 3) accelerate maturation. Using human induced pluripotent stem cell (iPSC)-derived neural cells, we will first couple combinatorial transcription factor screening with scRNA-seq to directly induce iPSCs into specific neuron subtypes guided by primary neuron GRNs. Second, we will program glial cell subtypes and reconstruct multi-cellular niche with neurons, analyze how niche cross-talk impacts cell fates and states, and use emerged GRNs to engineer niche-specific signatures. Finally, we will decode dynamic GRNs during neural maturation and screen for determinants to accelerate maturation. DECIPHER aims to dissect the causal links between GRNs and cell identities, offering mechanistic insights into drivers of cell identity changes with the ambitious goals to engineer precise and mature cell subtypes for disease modeling, cell therapy, and regenerative medicine. Our approach holds great potential to study diverse cell fate and state transition events, such as development, reprogramming, regeneration, and cancer. The perturbation atlas generated here will empower AI-driven predictive modelling to guide future cell engineering.

Keywords: cell fate and state engineering single cell multiomics induced neurons ipsc derived models gene regulatory network perturbation screening
Data is the new oil - a political history of the European computing industry (DITNO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Denmark,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 3
Project status: SIGNED

The “Data is the new oil – a political history of the European computing industry” project investigates the history of the European computing industry from the aftermath of the second world war until the present. The research will be based primarily on companies’ archives, State Archives, and the historical archives of the EU, and will place the evolution of the European computing industry in relation with the development of a European oil industry, the most successful example of developing a strong and globally competitive Europe-made industry against America’s first-comer advantage. By analysing the reasons of the failure to also establish strong European actors in the IT industry, the project will allow to better understand the reasons for the decline in European productivity, as well as what the role of the European Union (EU) can be in promoting the development of national or infra-national strong IT companies, able to compete with the current dominance of US companies alone. Furthermore, the project will consider the problem of the data economy in a historical perspective, analysing access to data as a commodity, in parallel to the problem of access to oil which dominated the geopolitical economy of the 20th century, testing the literature on the history of commodities on access to data. This will allow to cover a gap in the current literature on the history of the European computing industry, which focussed almost exclusively on hardware and software. It will also update the literature from international and media history with a reflection rooted in history on the role of data for current economic development.

Keywords: it industry,european capitalism,european businesses,european economic integration,data,oil industry,development,technology
Immersion cooling & advanced materials for heat recovery from data centers (MODERATOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Greece,Italy,Norway,Switzerland,Iceland
Call: Waste heat reutilisation from data centres (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5367540.0
EU funding (EUR): 4291975.75
Participants: 12
Project status: SIGNED

The MODERATOR project aims to improve the overall energy efficiency of data centres by developing an integrated system based on immersion cooling combined with novel and highly efficient long-term heat storage materials and systems. The main innovations of the project are related to the development and integration of individual components, which include (i) a novel designed immersion cooling system that enables heat recovery from data centres, (ii) a novel waste heat recovery (WHR) system using phase change materials (PCMs) for efficient low-temperature heat recovery, (iii) a highly efficient multilayer insulation system for thermal energy storage (TES) that uses recycled glass granules and microparticles to minimize heat losses and (iv) the integration of these components into an automated prototype for direct heat utilization and long-term storage. Furthermore, the project employs modeling and simulation activities, evaluation tools and dissemination methods to increase the exploitation potential of the developed technologies. The major outcome will be the operation and demonstration of a fully automated integrated prototype combining a 40 kW data centre immersion cooling system and a 500 kWh TES for WHR (TRL8). Potential utilization options of the stored thermal energy (i.e. space heating and electricity generation) will also be demonstrated within the project. The successful implementation of the MODERATOR project will have multiple impacts on different sectors. To accomplish all these results, the MODERATOR project will build upon the wide expertise of its 11 partners. In particular, the consortium consists of 3 research organizations and 8 SMEs with experience on various research and technological areas including materials science, systems design, process engineering, systems operation, modeling and simulation, technoeconomic, environmental and socioeconomic assessment, roadmap design, dissemination and communication, etc.

Keywords: immersion cooling,phase change materials,long term heat storage,multi layered insulation,demonstration,organic rankine cycle
Kinetic Exponent Network Analysis (KENA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Significant efforts are underway in Europe to re-shore the synthesis of active chemical ingredients (API’s) to ensure the safety and availability of medicine for its citizens. This goes hand in hand with innovations and process intensification. For example, doing multiple chemical reaction steps in one go, and/or by using continuous flow reactors that are more energy and solvent efficient, with a smaller footprint, scalable (by numbering-up), and cheaper to build and maintain. A key issue, however, of doing multiple reactions at once is that different reactants and products can react, thus forming a chemical reaction network (CRN). While CRN’s are ubiquitous in biological systems, they are mostly avoided in industry due to their complex behavior and effort needed to understand and quantify them. In this project, I propose a new method to analyse experimental kinetic data in order to directly determine the structure of the CRN. To this end, I will develop Kinetic Exponent Network Analysis (KENA) to study CRN’s that are of high interest for academia as well as industry. The change in concentration at early times can be described with power laws, from which the network connectivity of species population and thus the CRN structure can be deduced. KENA could then optimize the chemical conversion and selectivity of the desired products in CRN’s, contributing to efficient API re-implementation in Europe.

Keywords: chemical reaction networks kinetics optimisation
From the Margin to the Centre: Rights Development, Transitional Justice and Indigeneity in the Nordics (MARCEN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1498109.0
EU funding (EUR): 1498109.0
Participants: 1
Project status: SIGNED

Globally, indigenous peoples’ rights appear to become recognised to a greater extent, but are indigenous groups more included in settler states’ laws and societies? Built on the strong foundation of legal mobilisation, rights development and transitional justice theories, MARCEN aims to inaugurate a paradigm-shifting legal inclusion theory with broad implementation possibilities. With the goal of establishing a new scientific foundation to understand the interplay between supranational and national legal frameworks, governance practices, and the socio-legal position of indigenous groups, the first contours of this legal inclusion theory will be outlined using the most prominent indigenous group in Europe – the Sámi in the Nordic countries (Sweden, Norway and Finland) as a comparative case study. With the Sámi under scrutiny, MARCEN will address: 1) How supranational and national legal regulation and rights developments affect the governance of indigeneity; 2) The historical (1920s–2020s) perspective of indigeneity framing and governance; 3) The impetuses, scopes, and effects of indigenous truth and reconciliation commissions; 4) How indigenous groups have used law and global rights discourses to mobilise, voice claims and improve their position. Using an innovative methodology, MARCEN is uniquely positioned to bridge the interdisciplinary gaps in the interplay between international and national laws, policies, legal cultures, theory and practice. The legal inclusion theory will be the starting point of a prominent research field, with extensive applicability within and beyond indigenous rights. As such, the findings of the project extend to the fields of integration, migration, marginalisation, inequality and discrimination. Building on my 10-year track record covering socio-legal scholarship, MARCEN will give me the opportunity to enable the urgently needed shift towards greater understanding of legal inclusion and exclusion.

Keywords: legal inclusion and exclusion,indigenous peoples,rights development,transitional justice,comparative law,socio legal studies,legal mobilisation
Hop on Facility for Enhancing Children’s Lives with Biomarkers for Risk Stratification and Triage (ECHiLiBRiST-Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Spain,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 44.0
Total project cost (EUR): 399708.75
EU funding (EUR): 399708.75
Participants: 2
Project status: SIGNED

The overall ambition of ECHiLiBRiST-Hop-on is to add the widening partner, IT Clinical, to enhance the monitoring of the clinical trials of the EChiLiBRiST consortium. This will decrease the risk towards approval/registry of the evaluated products, while providing a unique opportunity to IT Clinical to expand its activity and tools to a new setting: the African continent.
Metabolic optimisation of intra-tumoral T cell motility (MOTM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Background. The tumor microenvironment markedly limits intra-tumoral T cell motility and the contact with tumor cells. Such a defective intra-tumoral motility of T cells is one of the main reasons explaining why current treatments based on reinvigoration/infusion of T cells to fight human solid cancers are unsuccessful. Metabolic reactions support T cell migration. Although T cell metabolism is severely de-regulated within different tumor areas, how this specifically affects intra-tumoral T cell motility is unknown. This aspect is important, since the metabolism of tumor-infiltrating T cells could be in principle easily modulated, opening a window of opportunity to improve current immunotherapy approaches against solid cancers, whose ineffectiveness is often associated with a poor intra-tumoral T cell motility. Objectives. I want to understand (i) which are the metabolic determinants of T cell motility, (ii) how the metabolic alterations within the TME affect T cell motility, and (iii) how to manipulate the metabolism of T cells and CAR T cells to improve their intra-tumoral motility and anti-cancer response. Main Methodologies. Viable tissue slices from human and murine tumors will be used to measure intra-tumoral T cell motility (real-time imaging microscopy) and metabolism (multiparameter imaging approaches, spatial gene expression, histo-cytometry) and to assess the consequences of the manipulation of the metabolic milieu on T cell distribution and motility. Also, CAR T cells will be engineered with new metabolism modules to improve their infiltration into solid tumor. Expected Results. The findings of this project will provide new insights into (i) how to improve the metabolic regimen of human solid cancer patients to increase T cell infiltration into tumor islets, and (ii) how to improve the infiltration of CAR T cells during adoptive cell immuno-therapy approaches by modulating their metabolism.

Keywords: t cell,cell migration,cell metabolism,anti tumor response,live imaging microscopy
QUANTUM-TOX - Revolutionizing Computational Toxicology with Electronic Structure Descriptors and Artificial Intelligence (QUANTUM-TOX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Portugal,Germany,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 1994770.0
EU funding (EUR): 1994770.0
Participants: 7
Project status: SIGNED

Toxicology is at a crossroads. With ever more drugs going to market and more chemicals having an environmental impact, the need for fast, cheap and accurate technologies to assess toxic effects is pressing. Computational toxicology provides an array of tools and methods for toxicity prediction only using computer approaches. Conceptually, computational toxicology has significant advantages since testing is fast and cheaper than in vitro. However, currently computational toxicology has severe limitations. Predictions typically use Quantitative Structure-Activity Relationship (QSAR) models that rely on large sets of molecular descriptors. This causes severe problems since the methodologies cannot assess chemicals different than the ones used to develop the QSAR models, and when that is possible, the very large number of descriptors limits understandability. Therefore, new methodologies are needed to address those shortcomings. This project will develop a new type of descriptor, totally based on quantum mechanics that can cover the whole chemical space and relies on a small number of parameters that are easily interpretable. Starting with meaningful chemical perturbations, that extract the behaviour of the chemicals in assumed mechanisms of toxic action, the approach will develop specific Electronic SIGNatures (ESigns). ESigns are mathematical invariants that map the results of the quantum chemical calculations. Using Artificial Intelligence, the ESigns will relate to toxicity. The new approach introduces a momentous change in computational toxicology. It can cover the whole chemical space, since we are abandoning predictions based on molecular structures, uses fewer parameters, and can be related to the new trends in toxicology regarding use of pathways information. In fact, it is a powerful tool to allow accurate toxicology predictions solely on the basis of biochemical and chemical insight.

Keywords: toxicology,quantum chemistry,computational toxicology,artificial intelligence,quantum theory of atoms in molecules