Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FIWARE for the Next Generation Internet Services for the WATER sector (Fiware4Water)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Greece,Romania,France,France,France,France,France,Netherlands,Netherlands,United Kingdom
Call: Digital solutions for water: linking the physical and digital world for water solutions (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2022-05-31
Duration (months): 36.0
Total project cost (EUR): 5700245.0
EU funding (EUR): 4997945.0
Participants: 16
Project status: CLOSED

FIWARE is a smart solution platform, funded by the EC (2011-16) as a major flagship PPP, to support SMEs and developers in creating the next generation of internet services, as the main ecosystem for Smart City initiatives for cross-domain data exchange/cooperation and for the NGI initiative. So far little progress has been made on developing specific water-related applications using FIWARE, due to fragmentation of the water sector, restrained by licensed platforms and lagging behind other sectors (e.g. telecommunications) regarding interoperability, standardisation, cross-domain cooperation and data exchange. Fiware4Water intends to link the water sector to FIWARE by demonstrating its capabilities and the potential of its interoperable and standardised interfaces for both water sector end-users (cities, water utilities, water authorities, citizens and consumers), and solution providers (private utilities, SMEs, developers). Specifically we will demonstrate it is non-intrusive and integrates well with legacy systems. In addition to building modular applications using FIWARE and open API architecture for the real time management of water systems, Fiware4Water also builds upon distributed intelligence and low level analytics (smart meters, advanced water quality sensors) to increase the economic (improved performance) and societal (interaction with the users, con-consensus) efficiency of water systems and social acceptability of digital water, by adopting a 2-Tier approach: (a) building and demonstrating four Demo Cases as complementary and exemplary paradigms across the water value chain (Tier#1); (b) promoting an EU and global network of followers, for digital water and FIWARE (cities, municipalities, water authorities, citizens, SMEs, developers) with three complementary Demo Networks (Tier#2). The scope is to create the Fiware4Water ecosystem, demonstrating its technical, social and business innovative potential at a global level, boosting innovation for water.

Keywords: water utilities
The next generation epigenetic medicine for inflammation (EPIMAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Netherlands,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2019-06-30
Duration (months): 54.0
Total project cost (EUR): 1294785.0
EU funding (EUR): 1294785.0
Participants: 5
Project status: CLOSED

Epigenetic mechanisms allow cells to adjust gene expression in response to environmental cues. Increased understanding of this area has led to excitement about the potential of applying epigenetic regulation to drug discovery. EPIMAC aims to pursue the potential of epigenetics as a novel and innovative therapeutic modality for immuno-inflammatory diseases, in particular Inflammatory Bowel Disease (IBD). IBD is a severe and disabling chronic inflammation of the gastrointestinal tract affecting millions of people worldwide. Current treatment strategies are not successful because the precise etiology unclear. It is increasingly clear that deregulated epigenetic processes are associated with the aberrant inflammatory response seen in IBD. Recent reports suggest that inhibitors of epigenetic modifications developed by GlaxoSmithKline (GSK), such as histone deacetylase (HDAC) inhibitors, bear potential in treating inflammatory states (Nicodeme et al, Nature 2010; Kruidenier et al, Nature 2012). The EPIMAC consortium has the ambition to educate a group of next-generation scientists that master genetics, epigenetics, target discovery, pharmacology, preclinical validation and regulatory issues, and at the same time have a good understanding of clinical implementations of the drug pipeline of our pharmaceutical partner GSK. GSK is one of the world's leading research-based pharmaceutical and healthcare companies that aims to team up with academic partners in EPIMAC through its dedicated discovery performance unit named EpiNova in conjunction with 2 immuno-pharmacology units. An SME specializing in epigenetic compound targeting to inflammatory cells, Chroma Therapeutics, will contribute technology to EPIMAC. EPIMAC will educate and train these scientists by providing them with a versatile and multidisciplinary doctoral program, allowing them to become excellent scientists skilled to overcome the current challenges in IBD.

Keywords: gastroenterology,inflammatory bowel diseases,drug development
Using clouds as a natural laboratory to improve precipitation forecast skills (CLOUDLAB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 3499926.0
EU funding (EUR): 3499926.0
Participants: 1
Project status: SIGNED

Clouds have been seeded since the 1940s. Aimed at inducing weather modification, the method uses chemicals to alter the microphysical processes within a cloud to enhance precipitation, suppress hail, or dissipate fog. While the concept of cloud seeding is not new, detailed knowledge about the underlying microphysical processes in clouds is still sparse. CLOUDLAB will tackle this gap by injecting different ice nucleating particle concentrations into supercooled stratus clouds to investigate related microphysical changes, including fundamental aspects of ice formation and growth. To achieve this, the project combines a multi-dimensional approach of targeted cloud seeding with a focus on wintertime stratus clouds in Switzerland, the least dynamic cloud type which best mimics laboratory conditions and allows repetition of field experiments under similar initial conditions. We will inject ice nucleating particles from a seeding drone and perform measurements with ground-based remote sensing, a tethered balloon system equipped with a holographic imager and a measurement drone. Combined with measured meteorological parameters, we aim to understand the impact of cloud inhomogeneities for precipitation initiation via the ice phase. The analysis of our cloud seeding events will be used to validate and improve cloud microphysics schemes in the Swiss weather forecast model in large eddy simulations mode. By coarsening the horizontal resolution to weather forecast mode, the simulations will be extended to include all cloud types where the same microphysical processes are at work to improve precipitation forecast skills in Switzerland. Hence, CLOUDLAB will further the understanding of ice microphysics and precipitation initiation which will also improve climate projections. In addition to pioneering of a new methodology of using drones for cloud seeding, our results will be of particular interest to the weather modification and climate intervention communities.

Keywords: ice formation,cloud seeding,cloud microphysics,mixed phase clouds,holographic imager,remote sensing,large eddy simulations,airborne field measurements,ice nucleating particles,tethered balloon,weather forecast
Printed Optoelectronic Devices from Nanosheet Network Electrochemically-gated Field Effect Transistors (2D-EG-FET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-16
End date: 2018-05-15
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Much research is underway to create a new class of inexpensive electronic devices fabricated by printing combinations of nanomaterial- & functional polymer-inks onto arbitrary substrates, such as everyday plastic film. This will open a route to a wide range of electronic, optoelectronic & electrochemical applications that are impossible using conventional silicon-based manufacturing approaches. For example, it will enable devices that are mechanically deformable (i.e. flexible or stretchable), optically transparent, or even cheap enough to be considered disposable. Innovative features such as these will enable electronic functionality to be integrated into locations where they are currently not feasible. As such, these printed electronics technologies will have applications in many areas of concern for modern society such as public security, healthcare & environmental protection. Here we aim to fabricate aerosol-jet printed ensembles of semiconductor nanosheets (i.e. nanosheet networks) with controlled composition & morphology, then fabricate these into electrochemically-gated field-effect transistors (E-gated FETs). This will enable the study of electronic transport, charge separation & recombination processes that occur within these networks with the view to apply them within cheap, printable photodetector & electroluminescent devices.

Keywords: printed electronics,nanosheets,2d materials,layered crystals transistor,electrolyte gated,liquid phase exfoliation,electrochemical transistors
Understanding DSB repair from pathway choice to long term effects and their consequences. (EpigeneticScars)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-07-31
Duration (months): 65.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

DNA safekeeping is one of the most important functions of the cell. Since DNA damage occurs in the context of chromatin, it affects both the DNA itself, but also the epigenetic landscape. While the repair mechanism of the DNA has been extensively studied, questions abound regarding the restoration of the epigenetic landscape, and the long-term effects that damage leaves in the region. In this proposal I aim to address these questions using modified DSBs repair sensors from different pathways such as “homologous recombination” and “non-homologous end joining” to map the repair process. Our method will allow us to investigate the influence of the natural epigenetic landscape on pathway choice, the dynamic process of repair and the restoration of the region. Moreover, we will investigate whether certain repair processes leave long- lasting effects at the site of damage or even “epigenetic scars”. The advantage of our method is that it allows us to map each sensor repair time-line in an unbiased and high throughput manner over extended periods of time, even once the damage is already repaired. These questions are especially important for our understanding of ageing, and age-related diseases that are driven by DNA damage. Last, we will test the long-lasting effects of past damage in two different contexts: animal models of neurodegeneration, where DNA damage accumulates, and in the efficiency of reprograming to produce healthy induced pluripotent stem cells (IPCs).

Keywords: double strand break repair,epigenetic signaling,dna damage response,ageing,dna damage sensor
The Europeanisation of Jazz during the Interwar Period: Beyond National Narratives (EURJAZZ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

EURJAZZ looks at the role played by music in the process of cultural europeanisation. It examines how a cultural product coming from outside Europe can become fully part of European culture and identity. Taking jazz as an example of such cultural expression, the project explores how its diffusion outside the United States (USA) led to the development of a unified European jazz world, which was distinctive and independent from the American one. Three aspects of europeanisation are examined in light of representative case studies, considered from a transnational and European perspective: self-affirmation; appropriations, individuation and differentiation from the USA; integration and cooperation. EURJAZZ also shows that these three elements played a critical role in the formation of the first European jazz institution: the European Jazz Federation (1968-1975). The project explores the role of music in shaping identities at European level. It takes the inherent interdisciplinary nature of musicology a stage further by designing a research and training plan with the aim of establishing research cooperation that is of mutual benefit to European and Anglophone scholarly traditions in the Humanities and Social Sciences. EURJAZZ is timely in building on recent research about national histories of jazz in Europe in order to initiate a change of scale in the study of the history of jazz. Besides, it tackles one major challenge of the H2020 programme: a better understanding of Europe’s cultural identity and heritage. It is timely in being implemented during the European Year of Cultural Heritage (2018) and on the 100th anniversary of the arrival of jazz in Europe. The dissemination and communication plans aim to contribute to these celebrations. EURJAZZ has strong societal relevance, at a time when Europe is facing the threat of partial disintegration and when current immigration raises questions about the capacity of Europe to assimilate non-European cultural products.

Keywords: music and transnational identities,europe,europeanisation,transational studies,jazz,cultural transfers,circulations,networks,interwar period
Functionalized Magnetic Resonance Beacons for Enhanced Spectroscopy and Imaging (FunMagResBeacons)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2762223.0
EU funding (EUR): 2762223.0
Participants: 1
Project status: SIGNED

This project will develop and demonstrate molecular agents called functional magnetic resonance beacons (fMRBs). These will provide a new set of versatile spectroscopic tools for the spatially resolved study of chemistry, biochemistry, diffusion, flow and percolation inside opaque objects. The fMRB agents support hyperpolarized nuclear spin order, which generates enormously enhanced nuclear magnetic resonance (NMR) signals. The agents are designed to maintain such order for long times (between 5 minutes and several hours) in ambient temperature solution, enabling their transport deep inside opaque objects. The molecules are functionalized, so that they “light up" in an NMR or magnetic resonance imaging (MRI) experiment, upon triggering by specific chemical signals or physical conditions (sensory functionality), and may also to bind to selected molecular targets (binding functionality). One set of proposed realisations possesses “lock-and-key” functionality, meaning that the hyperpolarized nuclear spin order is “locked” into a form which is invisible in the NMR spectrometer, but which may be “unlocked” at any chosen time by applying a suitable radiofrequency pulse sequence. The following molecular moieties are proposed as storage modules: (1) molecular cages, such as functionalized C60 fullerenes, encapsulating noble gas atoms such as 3He; (2) spin clusters supporting long-lived states, such as pairs of 13C or 15N nuclei, in shielded molecular environments. The sensory moieties include tailored peptide sequences, which may be activated by the presence of particular proteases, while binding modules include moieties such as biotin. The agents are designed to be conveniently transportable in a hyperpolarized state. Potential long-term applications include in vivo molecular imaging by MRI.

Keywords: nuclear magnetic resonance,hyperpolarization,long lived states,endofullerenes,molecular imaging
Theoretical prediction of spectral biomarkers for Alzheimer's disease enabled by highly efficient and adaptable mutli-level response methods (FreezeAlz)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Luminescent conjugated oligothiophenes are highly promising candidates for biomarkers for amyloid misfolds and thereby for early-stage detection of neurodegenerative diseases such as Alzheimer’s and Parkinson's disease. The elucidation of the microscopic mechanism and design principles behind these biomarkers requires theoretical assistance. Finding suitable theoretical models that allow sufficiently accurate spectra calculations for such large, dynamic, and complex biomolecular systems is a highly challenging task: In practice, it is currently neither possible to include all possible factors, nor to rigorously test their importance for the actual simulation. There is, hence, a great need for efficient and adaptive theoretical models capable of incorporating the essential factors in spectra calculation of biomolecular systems sufficiently accurately. In order to devise an efficient and adaptable methodology for assisting the interpretation of existing spectra and predicting the performance of new candidates for biomarkers, we will combine the advantages of several state-of-the-art computational methods. More precisely, we will combine the so-called frozen density embedding scheme with linear scaling density functional theory techniques and incorporate additional polarization effects in a manner inspired by the polarizable embedding method. We will moreover devise efficient and pragmatically adaptable schemes to accurately capture vibrational coupling in these spectra. All these method developments will be done in close collaboration with groups conducting the actual experiments. In this way, a strong interdisciplinary research project will be established. Still, the formulation and implementation of the new methods will be as general as possible in order to devise flexible methods that can easily be adapted to assist the investigation of also other future scientific questions.

Keywords: multi level approaches,theoretical spectropscopy
Critical Making: Studying RRI Principles in the Maker Community (Critical Making)

Framework: Horizon 2020 — Science with and for Society
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Austria,Finland
Call: Bottom-up approach to build SwafS knowledge base (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 1194500.0
EU funding (EUR): 1194500.0
Participants: 5
Project status: SIGNED

The Coronavirus (Covid-19) pandemic has shown the importance of the global maker community for a rapid response to the lack of medical hardware supplies and reveals the great social innovation potential of the maker movement. In Critical Making we want to add scientific insights into the potentials of the maker movement for critical, socially responsible making, and show how these communities can offer new opportunities for young makers of all genders to contribute to an open society via open innovation. Thus, we will study grassroots innovation processes taking place in maker spaces, hacker spaces, fablabs, etc. and online spaces and relate them to RRI practices. More specifically, we will search for and analyse existing innovation and co-design processes taking place in these open spaces to find out in how far they reflect or contradict RRI principles. Following a mixed method approach will enable us to collect data, analyse it, actively improve practices and develop theories and synthesise findings. Next to analysing existing practices, we will co-design, evaluate and disseminate concrete interventions that aim to foster RRI principles in the maker movement. In three case actions the project will specifically look at aspects of gender, openness and the recruitment of young talents. As a result we will co-define measure how to better implement RRI principles in the open innovation movement taking place across maker communities. Our findings will provide hands-on input for practitioners in the field and will enrich the scientific knowledge base in the RRI community on innovation processes outside of academia, aiming to harness the full innovation potential of the global grassroots maker movement.

Keywords: grassroots innovation,maker movement,gender,young talents,openness