Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Illuminating the Dark MicroProteome in Innate Immunity (MicroIMMUNE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Genome annotation, transcriptomic and proteomic pipelines have traditionally dismissed proteins encoded by short open reading frames (sORF) known as microproteins. This provides a pool of unexplored functional genes. Despite the increasing body of work in identifying the microproteome in different model organisms and cell lines, only a few have been functionally studied showing diverse regulatory roles in multiple cellular pathways. In MicroIMMUNE, I present a 3-aim workflow combining computational and synthetic biology, protein and genetic engineering approaches designed to systematically uncover the microproteome atlas and investigate its interactome and functional role in innate immune cells. We aim to: 1) Identify microproteins expressed in innate immune cells under resting and stimulating conditions, using state-of-the-art computational and experimental approaches to study the microproteome. 2) Develop genetic code expansion technologies in innate immune cells to incorporate non-canonical amino acids to study the localization and binding partners of microproteins. 3) Elucidate the function of microproteins in innate immune cells by combining genetic engineering with an array of high-throughput functional assays and automated analysis pipelines. Our research output will address key questions such as: What is the microproteome atlas in innate immune cells and how does it vary upon activation? Where are the microproteins localised and in which protein-protein interactions are they involved? What functions do different microproteins play in innate immune cells? Understanding the role of microproteins in innate immune cells can revolutionise our understanding of the immune response at a fundamental level and open new avenues for therapeutic interventions in which new antimicrobial peptides or druggable targets could be discovered.
Arctic Plant Regeneration From Seed Under Climate Change (ArcSeed)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 1
Project status: SIGNED

The Arctic is warming at twice the global rate, and Arctic plants are predicted to experience significant range loss in the coming decades. In this context, regeneration from seed is crucial for the long-term survival of Arctic plants, as it allows species to migrate to suitable areas or adapt to new environmental conditions. However, our current understanding of how climate change will affect seed regeneration in the Arctic is very limited. The overall aim of this project is to increase our understanding of how changing climatic factors and extreme climate-related events such as frost, fire and heat waves will affect (i) seed dormancy, (ii) germination and (iii) seedling establishment of Arctic plants. By focusing on understudied life stages, overlooked environmental factors, and using seeds from over 30 species collected from over 30 Arctic sites, this project will provide new insights into Arctic seed and seedling ecology, contributing to plant conservation and evidence-based management strategies in the Arctic. To achieve this, I will receive extensive training in seed ecology, manipulative experiments and advanced statistical analysis at the University of Copenhagen. The research activities, along with associated teaching and dissemination efforts, are designed to strengthen my future career as an independent researcher in academia.

Keywords: arctic,climate change,heat wave,fire,frost,seed dormancy,seed germination,seedling establishment
Scientific Large-scale Infrastructure for Computing/Communication Experimental Studies - Preparatory Phase (SLICES-PP)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: France,Netherlands,Greece,Italy,Poland,Switzerland,Hungary,Luxembourg,Germany,Spain,Sweden,Finland,Cyprus,Norway,Belgium,Ireland
Call: Preparatory phase of new ESFRI research infrastructure projects (HORIZON-INFRA-2021-DEV-02, 2021)
Start date: 2022-09-01
End date: 2025-12-31
Duration (months): 40.0
Total project cost (EUR): 2999591.25
EU funding (EUR): 2999590.5
Participants: 26
Project status: SIGNED

The digital infrastructures research community continues to face numerous new challenges towards the design of the Next Generation Internet. This is an extremely complex ecosystem encompassing communication, networking, data-management and data-intelligence issues, supported by established and emerging technologies such as IoT, 5/6G, cloud-to-edge computing. Coupled with the enormous amount of data generated and exchanged over the network, this calls for incremental as well as radically new design paradigms. Experimentally-driven research is becoming worldwide a de-facto standard, which has to be supported by large-scale research infrastructures to make results trusted, repeatable and accessible to the research communities. SLICES-RI (Research Infrastructure), which was recently included in the 2021 ESFRI roadmap, aims to answer these problems by building a large infrastructure needed for the experimental research on various aspects of distributed computing, networking, IoT and 5/6G networks. It will provide the resources needed to continuously design, experiment, operate and automate the full lifecycle management of digital infrastructures, data, applications, and services. Based on the two preceding projects within SLICES-RI, SLICES-DS (Design Study) and SLICES-SC (Starting Community), the SLICES-PP (Preparatory Phase) project will validate the requirements to engage into the implementation phase of the RI lifecycle. It will set the policies and decision processes for the governance of SLICES-RI: i.e., the legal and financial frameworks, the business model, the required human resource capacities and training programme. It will also settle the final technical architecture design for implementation. It will engage member states and stakeholders to secure commitment and funding needed for the platform to operate. It will position SLICES as an impactful instrument to support European advanced research, industrial competitiveness and societal impact in the digital era.

Keywords: digital infrastructure,future internet,iot,wireless,cloud,hpc,research infrastructures,experimentation,european research excellence in digital sciences
Microfluidic Alkaline eleCtrolysis for Green HYdrogen Via Electrochemical Reactions (MacGhyver)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: France,Spain,Netherlands,Germany,Poland
Call: Novel routes to green hydrogen production (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-09-01
End date: 2026-12-31
Duration (months): 52.0
Total project cost (EUR): 3644380.0
EU funding (EUR): 3644380.0
Participants: 6
Project status: SIGNED

MacGhyver has refocused its activities on a compact, scalable microfluidic alkaline electrolyzer for green hydrogen production with enhanced efficiency and the use of non-precious metal contents. The immediate objective is a 1 kW modular prototype employing high-ECSA electrodes and a 30-cell (10 × 15 cm) stack, enabling 0.45 kg/day hydrogen production at 1 A/cm² and 1.8 V with an energy demand of 56 kWh/kg H2. Reduced pumping requirements (<6 kWh/kg) target a overall production cost below €11/kg. By 2028, the project aims to scale to 10–20 kW systems with industrial partners, achieving 2 A/cm² at 1.8 V and costs below €5/kg, and ultimately extend to 100 kW+ modular systems for microgrids, decentralized industry, and green ammonia.
Continuous and Efficient Cooperative Trust Management for Resilient CCAM (CONNECT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Austria,Greece,Germany,Cyprus,Netherlands,France,Italy,United Kingdom
Call: Cyber secure and resilient CCAM (CCAM Partnership) (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 5656643.75
EU funding (EUR): 5656643.75
Participants: 17
Project status: SIGNED

CONNECT addresses the convergence of security and safety in CCAM by assessing dynamic trust relationships and defining a trust reasoning framework based on which involved entities can establish trust for cooperatively executing safety-critical functions. This will enable both a) cyber-secure data sharing between data sources in the CCAM ecosystem that had no or insufficient pre-existing trust relationship, and b) outsourcing tasks to the MEC and cloud in a trustworthy way. Beyond the needs of functional safety, trustworthiness management should be included in CCAM’s security functionality solution for verifying trustworthiness of transmitting stations and infrastructure. CONNECT will build upon and expand the Zero Trust concept to tackle the issue of how to bootstrap vertical trust from the application, the execution environment and device hardware from the vehicle up to MEC and cloud environments. This includes measuring the system when instantiating network functions and determining the integrity and origin of software. Trusted Execution Environments (TEEs), as sw- or hw-based security elements, will be essential to establish a verifiable chain of trust throughout the entire application stack of the host vehicle, as well as protecting data in transit, at rest and in use. By coupling the Zero Trust security principle with the need of “Never Trust, Always Verify”, CONNECT bootstraps vertical trust for all users, devices and systems in the CCAM ecosystem by enabling continuous authorization and authentication prior to be granted access to data or resources. Through TEE-enabled “Chip-to-Cloud" assurances and verifiable chain of trust, CONNECT reaches its full potential: not only does it mitigates risks stemming from the Zero Trust CCAM environment but also ensures resilience. This can make CONNECT the cornerstone of future smart transportation as it will usher new levels of safety and connectivity and bring vehicles even close to autonomy.

Keywords: 5g c v2x,ccam,trust assessment,security,safety,resilience,tee,verifiable credentials
Researchers' impact in everyday Life (BRIGHT-NIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-05-02
End date: 2024-05-01
Duration (months): 24.0
Total project cost (EUR): 295000.0
EU funding (EUR): 295000.0
Participants: 7
Project status: CLOSED

The BRIGHT-NIGHT 2022-2023 proposal, within the framework of the European Researchers' Night, aims at bringing research and researchers closer to the general public of the Tuscan region. In fact, the BRIGHT-NIGHT Consortium includes the main Tuscan universities whose decennial collaboration has already produced very successful ERN events. This objective will be achieved by showcasing research projects, with a specific focus on sustainability and societal challenges, through a rich and inclusive program of activities in open and public events throughout Tuscany. We will increase the awareness of how scientific research impacts on the daily lives of citizens, on the active role it can play in shaping the future and fostering young people’s interest in scientific studies with a gender balance approach, mostly in STEAM. After a set of preparatory events, the core activities will take place the last Friday/Saturday of September 2022/2023: hundreds of interactive, funny and inspiring activities in the cities, which will be populated by science hubs (shows, hands-on experiments, games, competitions, and exhibitions). To better stress the centrality of a joint European effort on the societal and sustainability challenges of our times, the event will revolve around the Horizon Europe missions, with particular emphasis on their interdisciplinary character. The two-year duration of the proposal will allow the involvement of students from primary and secondary schools encouraging to deliver a scientific presentation during the Nights: they will be supported by academic researchers, who will help them to select and prepare a topic. This activity aims at creating a long-term connection between researchers, (which will be trained on scientific communication skills for the purpose), young students and the general public. Such connection will make science research more "familiar", more understandable, and ultimately strengthen people’s trust in scientific methods.

Keywords: researchers,innovation,daily life,sustainability,environment,climate,planet,rights,poverty,inclusiveness,health,quality of life,communication,culture,participation
Overnight Vulnerable Emotion Reset Normalizing Invalidating Generalized Hyperaroused Tension (OVERNIGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands,Switzerland
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

Anxiety and insomnia account for one-third of the global mental health burden. Prognosis is poor: chronicity and relapse are common because treatment effectiveness is moderate. While this situation calls for treatment innovation, the required knowledge on targetable key mechanisms is lacking. Their shared core symptom is hyperarousal, covering subjective, physiological and clinical indicators. Hyperarousal is not 'just another overlapping symptom': individual differences in hyperarousal determine severity, prognosis and treatment response across insomnia-, anxiety- and stress-disorders. Hyperarousal links their genetic and phenotypic overlap. Since hyperarousal plays such a pivotal role in the development and chronicity of these disorders, a transdiagnostic mechanistic understanding of hyperarousal would have major implications for the direly needed development of better treatment. This project aims for a transdiagnostic mechanistic understanding of hyperarousal across wake and sleep and use to this insight to innovate treatment. The project will do so by combining large-scale data-driven approaches with targeted testing of the novel hypothesis that hyperarousal may be reset overnight. Crossing disciplines and diagnoses, the project will first deliver an integrated account of the subjective, brain structural, brain functional and physiological hyperarousal landscape. This approach will deliver unprecedented transdiagnostic insights into the lifetime development and underlying brain mechanisms of hyperarousal vulnerability and its consequences for mental health. Moreover, this approach will yield both innovative state-of-the art tools, as well as practical tools, to quantify hyperarousal. These tools will be employed in both experimental preclinical studies and immediately applicable transdiagnostic clinical interventions expected to considerably improve the perspectives of people suffering from the most common mental disorders by alleviating hyperarousal overnight.

Keywords: sleep,hyperarousal,insomnia,anxiety,prevention,emotion,mental health
INNOVATIVE NASAL VACCINES TO PREVENT PATHOGEN COLONIZATION AND INFECTION IN THE UPPER RESPIRATORY TRACT (NOSEVAC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Switzerland,United Kingdom,Italy,Belgium,Spain,Netherlands,Germany,Portugal
Call: Vaccines 2.0 - developing the next generation of vaccines (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 7369448.75
EU funding (EUR): 7369448.75
Participants: 14
Project status: SIGNED

Bacterial and viral respiratory infections are a leading cause of morbidity and mortality worldwide. Streptococcus pneumoniae and Bordetella pertussis, influenza virus and SARS-CoV-2, are responsible for diseases with major public health impact: community-acquired pneumonia, whooping cough, influenza and COVID-19, respectively. Vaccines against some of these diseases, administered by intramuscular or subcutaneous injection, do not prevent colonization or infection of the upper respiratory tract (URT), and therefore have limited impact on pathogen transmission. The NOSEVAC consortium aims to develop and assess innovative nasal vaccine platforms as a novel concept to block the earliest stage of infection, thereby inhibiting URT colonisation, transmission and disease. The project builds on a unique consortium of 12 renowned and complementary teams from the EU, UK and Switzerland. NOSEVAC’s objectives are to: • Develop vaccine formulations for nasal delivery of RNA- and protein-based antigens • Discover bacterial antigens that promote colonization of the URT • Use a combination of in vitro and in vivo models for optimal evaluation of vaccines efficacy • Identify key host immune factors required for long-term protection of the URT in human • Deliver two nasal vaccine candidates to fight S. pneumoniae and B. pertussis infection, and a single bivalent vaccine to prevent influenza and COVID-19 • Address acceptability of nasal vaccination Expected outcomes include (1) strengthening innovation in Europe by enriching the pipeline for novel vaccines against (new) respiratory infections, (2) increasing knowledge on the mechanisms underlying URT colonization, infection and immunity, and (3) evaluating nasal vaccine acceptability by stakeholders. NOSEVAC will develop strategic research avenues to fight respiratory pathogens including those with epidemic potential and will facilitate evidence-based decision making to policy makers and investors.

Keywords: bacterial and viral respiratory pathogens nasal colonization,infection and immunity vaccines secretory antibodies,t cell response
Flexibly Scalable Energy Efficient Networking (FLEX-SCALE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Greece,Italy,Spain,Germany,Switzerland,United Kingdom,Israel,Netherlands,Portugal
Call: Communication Infrastructure Technologies and Devices (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2026-03-31
Duration (months): 39.0
Total project cost (EUR): 4873551.25
EU funding (EUR): 4612555.5
Participants: 17
Project status: SIGNED

FLEX-SCALE advances disruptive research on complementary optical x-haul network technologies for Optical Switching Nodes and their Transceiver Interfaces that enable flexible capacity scaling (≥10 Tb/s rate per interface, ≥1 Pb/s capacity per link and ≥10 Pb/s throughput per optical node) based on utilization of ultra-high bandwidth photonic/plasmonic technologies and the efficient exploitation of optical spatial and spectral switching (UltraWide-Band Spectral & Spatial Lanes Multiplexing; UWB/SDM). The developed x-haul 6G optical network innovations will achieve record energy efficiency (sub-pJ per switched/transmitted bit ) and low cost, enabled by photonic integration and optical transparency, replacing/bypassing power-hungry and costly electronic processing systems (e.g., electronic routers/switches). The Optical Nodes and their Transceiver Interfaces will be controlled by ML-enabled SDN control plane approaches that incorporate new resource allocation algorithms and protocols relying on emerging information models and enabling autonomous programmable disaggregated open networks, which will optimize traffic flow routing across network layers and segments, improving network QoS (high rates, low latency, high reliability/availability) and low cost/power consumption, as required by 6G specifications. FLEX-SCALE consortium spans the value chain of industry/academia experts on the targeted topics (transformational transceivers and optical switches, network planning, operation algorithms and protocols development) with demonstrated experience on delivering on their promises, as indicated by their research output and exploitation towards new products, services and standards contributions. FLEX-SCALE is poised to extend Europe’s leadership in 6G x-haul with offerings of highest-capacity flexible optoelectronic interfaces and fast switching nodes that fully exploit the optical spatial/spectral resources with the use of novel algorithms and control-plane implementations