Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Macrophage Targets for Metastatic Treatment (Mac4Me)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Ireland,Spain,Switzerland,Australia,Italy,Finland,France,United Kingdom,Belgium,United States,Germany,Norway
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 4328716.11
EU funding (EUR): 4094748.0
Participants: 26
Project status: SIGNED

Immunotherapies promise to be the major break-through in the treatment of metastatic cancer, but effectiveness is limited to few cancer types. Metastatic neuroblastoma, breast and prostate cancer, affecting approximately 300,000 EU-27 inhabitants of all age groups in 2020, respond not or very poorly to current immunotherapies. To establish more effective immunotherapies, we need to better understand the specific tumour cell-immune host interactions at the metastatic site. The Mac4Me Doctoral Network adopts an innovative, multidisciplinary and cross-sectional approach, with a unique and dedicated research training programme to equip young researchers with scientific knowledge and transferable skills that are essential for today’s great demand in both academic and non-academic sectors. Mac4Me aims to understand the tumour cell-immune host interactions at the metastatic site. with an in-depth molecular and mechanistic understanding of the immune and matrix changes induced by tumour cells. We will use innovative animal-free organ-on-chip systems, that recapitulate early metastasis formation of brain, bone and liver. The retrieved knowledge from the preclinical models will be integrated in data from established clinical metastases and AI machine learning algorithms will be applied to identify new immune targets. Mac4Me will align with patients and the general public from the very beginning thereby bringing societal expectations and patient needs into the centre of the project to pave the way for new standards for shared decision making and acceptable health care solutions. Mac4Me will prepare a next generation of young scientists to start their own career as independent researchers being equipped with scientific knowledge and personal skills and integrating participatory science as a starting point to address the societal demand for more effective treatment solutions for incurable metastatic disease, such as neuroblastoma, breast and prostate cancer.

Keywords: metastasis,immuno oncology,macrophage targeting,ageing,matrix remodeling,prostate cancer,breast cancer,neuroblastoma,liver metastasis,bone metastasis,brain metastasis,citizen science
FAMILY-FOCUSED ADOLESCENT & LIFELONG HEALTH PROMOTION (FLOURISH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Austria,Moldova, Republic of,North Macedonia,Spain,United Kingdom,Serbia,Germany
Call: Non-communicable diseases risk reduction in adolescence and youth (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2501407.24
EU funding (EUR): 2501406.75
Participants: 8
Project status: SIGNED

Young people in Eastern Europe face risks to their health and wellbeing due to factors including violence, poverty, inequality, and other adverse experiences, exacerbated by the ongoing conflict in Ukraine. Programs focusing on the adolescent-caregiver relationship are an evidence-based solution to supporting adolescent health by addressing a cluster of common individual and family risk factors. Parenting for Lifelong Health (PLH) is one such program, developed for implementation and scale-up in low-resource settings. FLOURISH will adapt, implement, and evaluate the PLH Teens program. The program will be adapted to the service delivery and cultural setting of two countrywide health networks, in North Macedonia and Moldova, including the needs of the refugee populations from Ukraine. The program covers evidence-based skills, such as problem-solving and emotional regulation, for adolescents 10-14 years old and their caregivers. Through building skills and strengthening the adolescent-caregiver relationship, communication, and caregiver monitoring, the program has the potential to prevent and reduce multiple common mental health problems and risk behaviors, such as alcohol misuse, therefore reducing the risk of future non-communicable diseases. Informed by co-production with stakeholders and intervention process evaluation, FLOURISH will explore the cost-effectiveness of intervention components and test the final intervention package in a hybrid implementation-effectiveness randomized trial, as well as develop a scaling strategy informed by qualitative data and statistical modeling. The project will foster methodological innovation. FLOURISH will advance the uptake and scale-up of evidence-based, open-source, and sustainable family interventions for adolescents in low-resource settings, and therefore have a profound impact on reducing the risks for future non-communicable diseases.

Keywords: parenting programs,adolescence,family focused intervention,implementation science
Regional Inclusive Biobased Entrepeneurship Solutions (RIBES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Greece,Belgium,Germany,Spain,Poland,Bulgaria,Croatia,North Macedonia,Romania,Serbia,Slovakia,Ukraine
Call: Revitalisation of European local (rural / peri-urban) communities with innovative bio-based business models and social innovation (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 4999455.0
EU funding (EUR): 4999455.0
Participants: 20
Project status: SIGNED

RIBES will address the need to enhance the uptake of biobased innovations through pioneering governance and business models developed on the convergence of the circular bioeconomy, social innovation and rural development, thus contributing to the shift from a linear to a circular economy in 9 European regions lagging in innovation. Project activities will focus on specific sub-national levels but will also encompass proactive dissemination and replication at the country level. Participating regions have been selected based on various socio-economic indicators and data concerning the characteristics of the agricultural and biobased sectors, demographics, innovation capacity, etc. RIBES will perform an in-depth multidisciplinary assessment of regional bioeconomy ecosystems and research possible correlations between the socio-economic trends, innovation bottlenecks and the role of the primary sector. RIBES will create a significant impact by delivering innovative and tailored governance solutions and business models capable of fostering grass-rooted circular bioeconomy value chains, with particular attention devoted to the advanced sustainability of regional inclusive biobased entrepreneurship solutions, thus contributing to strengthening rural development and innovation in participating regions. RIBES will implement 9 local Multi-actor Transformative Forums (MTFs) based on the Living Lab and Open Innovation concepts to address complex societal challenges and problems by putting stakeholder participation and deliberation processes at the centre, aiming at systemic transformative change (instead of only addressing symptoms) in the three pillars of technological, social and economic innovation to co-create tailored business and governance models.

Keywords: circular bioeconomy,social innovation,social entrepreneurship,green transition
Quantifying the formation and evolution of the Archaean lithospheric mantle (LITHO3)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1944116.25
EU funding (EUR): 1944116.0
Participants: 1
Project status: SIGNED

The formation of the Archean lithosphere was a key event in Earth history, resulting in the construction of the first continents, or cratons. The lithosphere formed by extensive mantle melting, however, there are conflicting models for the environment in which melting took place. Efforts to understand the formation of the cratonic lithosphere are hampered by a lack of quantitative information on the depth of mantle melting and the original thickness of the Archean lithosphere. Exsolved orthopyroxenes within peridotite xenoliths and silicate inclusions in diamond hold the key to constraining these critical parameters. We will reconstruct the original compositions of an extensive collection of exsolved orthopyroxenes and use our recently published thermodynamic model to calculate their formation pressures and temperatures. This innovative approach will reveal the depth extent of Archean melting. We will provide the first constraints on the vertical extent of the lithosphere in the Archean using geothermal gradients calculated from dated diamond inclusions. To achieve this, we will perform cutting edge laser ablation U-Pb dating of garnet inclusions, this challenging application has yielded promising results for xenolithic garnet. Observations will be complemented by new experiments using fertile, depleted and silica-enriched compositions, coupled with with thermodynamic modelling, which will lead to a better understanding of phase relations during peridotite melting. The origin and significance of silica enrichment is poorly understood. We will conduct melt-rock reaction experiments to test the hypothesis that silica addition occurred via interaction with ascending komatiite melt. We will thus address several fundamental issues: the depth of Archean mantle melting; the origin of silica enrichment; and the link between cratonic peridotite and komatiite magma. LITHO3 will provide unprecedented insight into the formation and evolution of the cratonic lithosphere.

Keywords: lithosphere,craton,exsolution
Design of Intelligent RIS-Aided Cell-Free networks for Energy-efficient Coexistence between eMBB+ and mMTC+ (DIRACFEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-03-31
Duration (months): 26.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

In our modernized era, beyond-5G and 6G wireless systems will be key to satisfying crucial society demands. The new challenging 6G KPI, the renewed need for sustainable and green networks, and the introduction of AI and sensing, evinces the necessity of incorporating new technologies and of designing novel solutions. In that sense, cell-free massive MIMO, reconfigurable intelligent surfaces (RISs), and edge intelligence are anticipated to be key technologies in the 6G era. DIRACFEC is a 24-months research project that thus concentrates on the Design of Intelligent RIS-Aided Cell-Free networks for Energy-efficient Coexistence between evolved eMBB (eMBB+) and evolved mMTC (mMTC+). More specifically, considering user-centric architectures and distributed multiple antenna deployments, we will present a set of multiple access schemes, edge intelligence techniques, and transmission strategies that optimize the energy efficiency in a heterogeneous service environment, aiming at the coexistence of eMBB+ and mMTC+ services. We will conceive mathematical frameworks to model dense networks where several RISs are controlled by multiple antenna access points. Then, to boost the ultimate performance, we will design the aforementioned approaches for different types of data traffic under the assumption of imperfect channel knowledge. These solutions will be evaluated using numerical and industry level system-level simulations in practical setups. The project will be carried out by the researcher at the University of Cassino and Lazio Meridionale (Italy), under the supervision of Prof. Stefano Buzzi. Furthermore, Nokia Bell Labs (France) will host the researcher for a six-months secondment aimed at validation of the developed solutions on industry level system simulators. The applying researcher is Dr. Sergi Liesegang, a fresh PhD graduate from the Politechnic University of Barcelona (Spain).

Keywords: 6g wireless networks,cell free massive mimo,reconfigurable intelligent surfaces,energy efficiency,internet of things,broadband communications,machine type communications
Accelerating the achievement of EU Green Deal Goals for pesticide and fertilizer reduction through AI, data and robotic technologies. (Smart Droplets)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Greece,Netherlands,Spain,Serbia,France,Lithuania
Call: AI, Data and Robotics for the Green Deal (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 3175475.25
EU funding (EUR): 2998370.0
Participants: 10
Project status: SIGNED

Due to a lack of a holistic approach combining physical and digital assets for optimal field performance and minimum environmental impact, AI models, data and autonomous robotic systems in crop care tasks have not reached a mature technological level. The conventional spraying methods result in excessive pesticide and fertilizer use, posing severe environmental impact - being responsible for soil, water and air pollution, and harming non-target plants, insects, animals and humans. Smart Droplets’ main objective is to advance both hardware and software capabilities to deliver a holistic system capable of translating large amounts of data into meaningful information and impactful spraying commands on the field. To demonstrate substantial impact on the Green Deal, Smart Droplets will implement Autonomous retrofit tractors with Direct Injection System (DIS) for intelligent spraying - avoiding exposure of farmers to hazardous chemicals. Through the combination of high-level technologies (>TRL 7), Smart Droplets adopts a hybrid approach for spraying operations, combining Data/AI/Digital Farm Twin technologies designed to translate data into actionable information, and real-time data collected from Field demonstrators evaluating and demonstrating optimised technologies in the real environments. Smart Droplets will exploit synergies with relevant stakeholders, and intensify Community & Capacity building through dedicated training programs designed for non-expert users of AI, data and robotics systems. The Smart Droplets Consortium consists of all agricultural AI, data and robotics value chain actors, and is well balanced in terms of expertise, entity type, and geographical distribution necessary to meet its objectives. Smart Droplets will demonstrate how autonomous robotic platforms, innovative spraying, digital twin and AI models, can deliver environmental, economic, regulatory, business, scientific, and societal benefits, assisting in the achievement of Green Deal goals.

Keywords: digital twins,ai,robotics,direction injection spraying,autonomous navigation,slam,retrofit tractors,hardware,software,data,training,stakeholder engagement,multi actor
Realising two-dimensional heavy fermions in rare-earth intercalated transition metal dichalcogenides (2D RE-TMDCs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-06
End date: 2027-10-05
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Quantum materials exhibit unique emergent phases driven by many-body interactions, and a major goal of material science is to harness their properties. Importantly, such materials are sensitive to external stimuli by often being close to quantum criticality, where fluctuations near critical points give rise to phenomena like high-temperature superconductivity and exotic magnetic phases. This opens routes for manipulating and controlling key quantum states. Heavy fermions (HF), characterized by competing magnetic and Kondo interactions, are central to quantum criticality. Dimensionality reduction is an exciting route to control the ground states of HF, as lower dimensions enhance fluctuations and electron correlations. However, the intermetallic nature and thus three-dimensionality of conventional HF make accessing two-dimensional (2D) HF challenging. The project aims to establish intercalated transition metal dichalcogenides (I-TMDCs) as a versatile platform for realizing HF phases in 2D monolayer films. I-TMDCs are ideal for engineering Kondo physics. Their layered structure enables creation of new electronic phases via intercalation. The flexibility in choosing intercalant, host material, and intercalation ratio adds tunability over magnetic and electronic properties, while also providing a route to dimensionality reduction in 2D films. This project will leverage the precision of molecular-beam epitaxy (MBE) in combination with the advanced spectroscopic techniques angle-resolved photoemission spectroscopy (ARPES) and low temperature scanning tunnelling microscopy (STM). Together with theoretical modelling, the methods will offer a comprehensive approach to determining the low energy electronic structure and ground state of I-TMDCs. By building upon conventional I-TMDCs, the project will introduce strongly correlated properties of f-electrons and HF physics via rare-earth intercalation, ultimately establishing a novel and tuneable class of 2D HF materials.

Keywords: two dimensional materials heavy fermions intercalated materials angle resolved photoemission spectroscopy scanning tunnelling microscopy molecular beam epitaxy
Ocean Glow: Controls on ocean productivity using ocean fluorescence detected from space (Ocean Glow)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Primary production in the ocean is critically important for human wellbeing - it regulates atmospheric carbon dioxide as well as sustaining almost all ocean life. But models predicting the impacts of climate change do not agree on the sign of ocean primary production in the coming century. Currently, satellite observations tell us how ocean primary productivity is changing, but not the underlying controls. Fieldwork and modelling show nutrient limitation is key, but there is currently no way to observe nutrient limitation at the scales needed to monitor climate change impacts or benchmark the accuracy of models. This project aims to overcome the scaling problem using direct, nutrient-regulated fluorescence signals passively emitted from phytoplankton and detected by satellite sensors in space. Although recorded for almost two decades, these signals have been confounded by uncertainty. In Ocean Glow I will take a two-pronged approach to break through the current blockage. In the first prong, a novel laboratory mesocosm facility will be constructed and used to quantify the key factors regulating phytoplankton fluorescence emission, in the same way that it is stimulated and detected by satellites. In the second prong I will connect these experimental results with the real world by undertaking field observations on research cruises through the global ocean, using approaches that I have pioneered in my previous research. Finally, I will use this ground-based assessment to perform data-informed deconvolution of the satellite fluorescence signal to observe nutrient limitation at a global, time-resolved scale using the existing, two-decade satellite record. In making a step change in the utility of satellite-detected fluorescence, Ocean Glow will deliver the tool needed to make mechanistic assessments of how climate change is impacting ocean productivity.

Keywords: ocean productivity,phytoplankton,micro nutrient limitation,chlorophyll fluorescence,remote sensing,ground truth