Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tracking adaptation of naïve T cells to distinct organs to decode organ-specific immune diseases (ADAPT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1999000.0
EU funding (EUR): 1999000.0
Participants: 1
Project status: SIGNED

Organ-specific immune-mediated inflammatory diseases (IMIDs) have a growing socio-economic impact due to their steadily increasing incidence. At least two aspects are still unclear: what immunological mechanisms restrict these diseases to one or a set of specific organs and what triggers the continuously increasing incidence, particularly in industrialized countries. Increasing exposure to harmful environmental triggers, such as pollution but also Western diet, have been suggested as potential reasons. We propose that when locally active immune cells are perturbed by harmful environmental triggers this leads to organ-specific IMIDs. Naïve CD4+ T cells have so far been considered a quasi-homogenous and inert population excluded from organs. Therefore, their contribution to organ-specific IMIDs has been overlooked. Contrary to this, there is evidence that naïve T cells circulate through organs and diversify into different subpopulations reflecting the organ they patrol. This project aims to reveal whether organ adaptation of naïve T cells in steady state is one of the key mechanisms contributing to the organization of the immune system into districts of competence - i.e., areas of inflammation. We also aim to understand whether organ-specific naïve T cells responding to harmful environmental triggers set the early premise for the development of organ-specific IMIDs. We will study this using a unique portfolio of healthy and diseased human organs in combination with multi-modal single-cell technologies to gain an unprecedented resolution in the analysis of naïve T cells. Next, we will use mouse models and 3D human cocultures to test naïve T cell function and response to environmental triggers. This project will influence the current understanding of how the activity of the immune system is adapted and distributed throughout the body, which will also push the boundary of precision medicine to consider organ-specific naïve T cells when designing future immunotherapies.

Keywords: human and mouse immunology,immune related diseases,adaptive immunity,systems immunology
Improving Renewables Penetration Through Plug and Play Microgrids (RePower)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Denmark,Germany,Ghana,Senegal,Niger,Madagascar,South Africa,Kenya,Spain,Serbia
Call: Demonstration of innovative plug-and play solutions for system management and renewables storage in off-grid applications (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 12706411.57
EU funding (EUR): 9988745.87
Participants: 15
Project status: SIGNED

For Africa to meet its 2030 SDG7 targets and ambition of attaining energy-for-all by 2040 and climate neutrality by 2063, the proportion of renewables in the current energy mix needs to be dramatically improved through robust and effective technologies, sustainable business models, a skilled technical workforce and an enabling regulatory environment. RePower will contribute to these efforts by demonstrating and validating a modular and scalable plug and play (PnP) microgrid system based on photovoltaics (PV) and biomass combined heat and power (BCHP) augmented with a battery energy storage system (BESS) and an intelligent energy management system (EMS), and by providing tools, processes and a roadmap to replicate the installation of this modular plug-and-play microgrid system at any other location. The modular and scalable RePower microgrid system will build upon the Solartainer, an existing and containerised PV-BESS solution that has already been successfully piloted by project partner, AGT, in 21 locations empowering 25,420 customers in remote off-grid locations and providing 934 SMEs with power in Mali, Niger and Chad. The new Solartainer RePower combined with a unique BCHP solution will have the capacity and flexibility to provide distributed, affordable, reliable and stable electricity as well as heat and cooling to off-grid communities in Senegal, Niger and Madagascar. Compared to the average PV-based microgrids currently on the market for Africa, the RePower setup including BCHP will improve the renewable energy generation capacity of the existing plants by over 50% while also reducing the unit cost of electricity by about 60 % – 70 % allowing consumers to extend electricity usage to the productive use of energy (PUE), such as farming, water pumping, food processing, construction and other small-scale industries. The modularity of the system allows sizing to meet the demands any specific application or locality, thus matching energy supply with demand.

Keywords: off grid energy systems microgrid energy storage energy management prosumers
Development of a lung METAstasis-on-a-CHIP model for osteosarcoma as a biomimetic testing platform for drug discovery and therapeutic innovation (META-CHIP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1499884.0
EU funding (EUR): 1499884.0
Participants: 1
Project status: SIGNED

Osteosarcoma is a highly aggressive bone cancer that primarily affects children. Secondary lung metastasis is the most critical clinical factor, with 70% of those who develop lung metastasis succumbing to the disease within 3 years. Despite the resonating clinical urgency for newer, more effective treatment options, there have been no changes in treatment since the introduction of chemotherapy in the 1970s. Furthermore, osteosarcoma is a rare disease making the conduct of large clinical trials investigating novel therapies very challenging. META-CHIP proposes to embark upon frontier research by being the first to develop a lung metastasis-on-a-chip model for osteosarcoma, for use by both the research community and the pharmaceutical industry. This will be realized by first testing the hypothesis that patient derived tumour spheroids (PDTS) generated from patient biopsies will recapitulate the primary tumour and thus be a superior drug development model than traditional cell culture models (Aim 1). An osteosarcoma-on-a-chip device will be developed integrating PDTS, microfluidic technology, and novel biomaterial design to provide a more accurate model of the tumour microenvironment (Aim 2). To validate the device, the ability to predict clinical outcomes on tumour growth following treatment with two anti-angiogenic drugs, which have progressed to Phase II clinical trials will be assessed (Aim 3). Finally, META-CHIP will develop a much-needed platform which mimics key aspects of osteosarcoma metastatic disease progression to the lung. This will be achieved through functional-coupling of the osteosarcoma-on-a-chip device with an established lung-chip to create a medium-throughput, cost-effective, human systemic model of osteosarcoma metastasis (Aim 4). META-CHIP has the potential to revolutionise drug development and treatment of osteosarcoma patients by being the first ex vivo testing platform capable of predicting a patient’s response to therapies in real-time.

Keywords: osteosarcoma organ on a chip devices lung metastasis cell communication,microphysiological systems cancer models biomimetic materials
THE POTENTIAL OF RESEARCH DATA – HOW RESEARCH INFRASTRUCTURES PROVIDE NEW OPPORTUNITIES AND BENEFITS FOR SOCIETY HIGH-LEVEL PRESIDENCY CONFERENCE ON RESEARCH INFRASTRUCTURES (ResearchData4Society)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Sweden
Call: Swedish Presidency conference on Research Infrastructures 2023 (HORIZON-INFRA-2023-SE-CONF-ART195-IBA, 2023)
Start date: 2023-05-01
End date: 2023-12-31
Duration (months): 8.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Europe has one of the most advanced and integrated research infrastructure systems in the world. During the last years, Europe has invested large sums in research infrastructures, i.e., state-of-the-art experimental facilities to reinforce Europe’s research and innovation system by providing research communities with unique expertise, instruments, technical resources, data, and services. This facilitates the performance of cutting-edge basic and applied research, boosting of technological advancements and breakthrough innovations. They also bring benefits to industries and SME’s. Research infrastructures provide knowledge-based solutions to societal challenges and aids in the delivery of the EU’s green and digital transitions. Research infrastructures is a top priority for the current trio of French, Czech, and the Swedish presidencies of the European Council. The objectives of the Swedish presidency conference on research infrastructures are: • Making research infrastructures more visible by directing towards the capabilities of reusable and open data for research and societal benefits sensu lato. • Identifying challenges and means to face them by increased collaboration between sectors and stakeholders. • Accelerating the creation of values from research infrastructures by further developing and strengthening the work with reusable and open data for producers and consumers. The conference is arranged in Lund, a high impact research and research infrastructure hub, bringing together 250 people from a range of sectors from different levels that benefit from research infrastructures and open data and science to discuss relevant topics. The values foreseen after the conference are further strengthening of research infrastructures and facilitation of broader success to them, aid of future funding of these facilities, increased trust in science, and contribution to the competitiveness of European society and economy.

Keywords: research infrastructures,research data,open data
Revealing hadronic effects in B-meson decays (RELIGHTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 292118.88
EU funding (EUR): 292118.88
Participants: 1
Project status: SIGNED

Indirect New Physics searches are becoming increasingly important in the quest for physics beyond the Standard Model (SM). Since these heavily rely on the precision that can be obtained both in theory and in experiments, being able to achieve good control over non-perturbative effects, which are usually the main source of theoretical uncertainty, is of utmost relevance. With this postdoctoral fellowship, I will perform a comprehensive study of non-factorisable soft-gluon contributions in B-meson decays, focusing on the tree-level non-leptonic decays like $\bar B^0 \to D^+ K^-$, and on the rare semileptonic decays like $B_s \to \phi \ell^+ \ell^-$. In fact, for both types of processes, several tensions have been observed between the SM predictions and the corresponding data, and for both types of discrepancies, the dominant source of theoretical uncertainty stems from hadronic effects. Specifically, the computation will be performed using the well-established framework of light-cone sum rules (LCSR), employing the light meson (\pi,\phi, K^{(*)}) light-cone distribution amplitudes (LCDAs). The proposed project will represent the first calculation of these hadronic effects within this method and will make it possible to circumvent current challenges that arise when using B-meson LCDAs. Furthermore, particularly for the rare semileptonic decays introduced above, this approach will lead to a significant reduction of the theoretical uncertainties, as local and non-local form factors will be computed within LCSR using the same inputs. Therefore, the proposed research will be of considerable help in assessing the nature of the observed tensions and ultimately in exploiting the rich amount of future data available.

Keywords: b physics,light cone sum rules,hadronic effects
Measuring and Understanding Disparities in Family Formation in Low- and Middle-Income Countries (DisparFam)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

The first union formation and the birth of the first child are among the most critical events shaping men’s and women’s life-course trajectories. Sustainable Development Goals (SDG) stress that all individuals should have access to means that allow them to control their fertility and should be able to marry at an age that does not harm their development capabilities. Central to SDGs is eradicating disparities in the timing of family formation, yet the understanding of their global patterns and determinants is limited, particularly in low- and middle-income countries (LMICs). This is a critical research gap as many women in LMICs enter their first union and become mothers very early in life and much earlier than men, which puts them at risk of adverse health outcomes. Focusing on 69 LMICs this project aims to radically improve our understanding of global family changes by providing novel empirical evidence on a critical yet poorly understood topic. Namely, using nuanced indicators, I will deliver the first-ever global examination of changes in disparities in the timing of family formation, both within and between the populations of women and men. Subsequently, I will investigate the role of an under-research dimension of education - schooling quality – and the role of gender inequality in opportunities in driving these disparities. This project will straddle the disciplines of demography, sociology, and international development to produce cutting-edge research that will improve the scientific understanding of social inequalities. By delivering novel evidence about the role of educational and gender inequalities in shaping young adults’ family formation trajectories, this project will be of value to the wider research and policy community, including organizations such as the UN. It will inform public policy on causes and solutions to critical global problems affecting millions of individuals worldwide, such as very early marriage, parenthood, and gender inequalities.

Keywords: family formation,low and middle income countries,gender inequality,education,survey data
Collaborative System of Systems Exploration of Aviation Products, Services and Business Models (COLOSSUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,France,Italy,Netherlands,Romania,Switzerland
Call: Digital aviation technologies for new aviation business models, services, emerging global threats and industrial competitiveness (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-02-01
End date: 2026-04-30
Duration (months): 39.0
Total project cost (EUR): 4418604.12
EU funding (EUR): 4418603.56
Participants: 14
Project status: SIGNED

COLOSSUS paves the way for future European aviation products and services which are designed in a truly holistic approach and to thus provide a major contribution to the digital transformation of aviation and air transportation in order to enable European competitiveness in a key industrial sector. The expected outcomes of COLOSSUS provide Europe’s aviation sector with the platform to develop new and breakthrough product and technology in a holistic system-of-systems approach. Main technical objectives of COLOSSUS are: (1) To create a Transformative Digital Collaborative (TDC) Framework that allows European aviation to perform research, technology development and innovation in a holistic system-of-systems approach. The TDC Framework shall support modelling, analysis, optimisation and evaluation of complex products and services under consideration of real-world conditions. (2) To expand and test the capabilities and performance of the TDC Framework with two Use Cases, both of which address needs identified in the Work Programme and thus possess a value of their own: Use Case 1: Creating a business model for sustainable 4D-intermodal mobility and evaluating the concept for performance, competitiveness, environmental impact and life cycle footprint. Use Case 2: Developing an integrated fast-response approach for preventing, detecting and fighting wildfires by combining latest developments in the fields of aircraft design and technology, automation, AI and digitalisation. (3) To perform conceptual studies for two products which could be transverse technology enablers for multi-modal mobility and affordable decarbonisation of aviation: a multi-role seaplane with hybrid propulsion and a product for eVTOL-based advanced air mobility of passengers and goods.

Keywords: system of systems,digitalization,aircaft desing,digital technologies,collaborative design,agent based simulation,optimization
Science, Environment, Art, Research (SEARCH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Bulgaria
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 235802.29
EU funding (EUR): 220879.0
Participants: 23
Project status: CLOSED

Science is the poetry of reality and 15 Bulgarian universities, research institutes and NGO partners join together in SEARCH to prove the statement that, combining Science + Environment + Art will bring Resilience for European Researchers Night in 2022-23. The experienced consortium led by Center for Research & Analysis and numerous associated partners bring longitudinal insight from their own 5 years’ partnership as well as EU and national findings in this 24-month project which aims to assert among the general public the crucial role of science in society and its relevance to everyday lives, and heighten young people’s interest in research careers, including of those from small towns and villages, and young people with disabilities. True to our approach, our country-wide, hybrid, multidisciplinary, hands-on programme of science and art events will focus on one central topic per year – the most versatile material in human history and its essential role in society, for technological, scientific and economic advancement – glass (UN International Year of Glass 2022), and the most urgent existential choices humanity needs to make – adapting to climate change, one of the new EU Missions supporting the European Green Deal. SEARCH for the popular formats of researchers’ public engagement like inspiring talks, spectacular shows and hands-on experiments, a range of sci-art collaborations, researchers at schools activities, and the innovative Young Voices podcasts and Instagram Looking Glass competitions. We will reach 3.6 mln, and engage with 30,000 direct participants online and offline, including teachers and school pupils, and along with boosting public engagement skills of researchers and teachers, we will demonstrate irrevocably how relevant, exciting and important the job of researchers is, and encourage young Bulgarians, especially girls and people with special needs to choose STEAM careers.

Keywords: research,innovation,multidisciplinarity,science communication,public engagement
THE URBAN BURDEN OF DISEASE ESTIMATION FOR POLICY MAKING (UBDPOLICY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,United Kingdom,Sweden,Belgium,Switzerland
Call: Methods for assessing health-related costs of environmental stressors (HORIZON-HLTH-2022-ENVHLTH-04, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2765718.75
EU funding (EUR): 2765718.75
Participants: 6
Project status: SIGNED

In Europe, more than 70% of the population lives in urban areas. Cities have long been known to be society’s predominant engine of innovation and wealth creation, yet they are also a main source of pollution, disease and mortality, which is to some extent linked to suboptimal urban and transport planning practices. The proposed work aims to improve the estimation of health impacts and socio-economic costs and/or benefits of environmental stressors, advance methodological approaches and foster their acceptance as common good practice for urban areas, to help strengthen evidence-based policy making at city, national and EU level. We will focus on nearly 1000 cities and environmental stressors including air pollution, noise, temperature/heat and lack of green space but we will also include physical activity as a main determinant of health and examine the effects of gender and inequality in the impact estimations. We aim to produce a system that will provide updates every 3 years to be able to monitor progress. It will extensively involve stakeholders and conduct knowledge translation. We will use transdisciplinary and systemic approaches bringing together a team of, amongst others, experts and practitioners in urban and transport planning, environment and public health, economics, retail and business, education sector, policy analysis, knowledge translation and involve citizens and NGOs.

Keywords: health impact assessment,socio economic impact assessment,cities,health,stakeholders