Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Separation of Nanoparticles (NP) in Multiphase Systems (MuPSs) (NPINMUPSS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2015-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

In biological systems, functions involving molecular recognition are crucial since key interactions in the body, such as protein-ligand and protein-protein interactions, depend on molecular binding events (e.g., hydrogen-bonding, π -stacking, and electrostatic interactions). Nanoparticles with molecular recognition properties found promising applications in biotechnology due to the advantages that the nanoscale offers, such as clear optical signatures and a high surface area-to-volume ratio. Nanoparticles exhibit size, shape, chemistry-dependent properties. Current nanoparticle synthesis methods produce heterogeneous populations. There is a need for a cost-effective and easy-to-use method which can enrich the populations of nanoparticles based on size, shape and chemistry. In this proposal, we will present such a toolbox to enable this kind of separations, use the enriched populations of nanoparticles in technological and scientific applications, and carry out nanotoxicology studies correlating the response of living systems to the exposure of homogeneous nanoparticles.

Keywords: c128 nanomaterials,c127 materials for sensors,c106 analytical chemistry,g311 materials engineering
A MOLECULAR, GENOMICS AND GENETIC ANALYSIS OF NEW STEM CELL FORMATION DURING ROOT MORPHOGENESIS (NEW ROOT STEM CELLS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-15
End date: 2016-09-14
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Stem cells are indispensable for development and growth in all multicellular organisms. In plants, stem cells formed embryonically generate new organs and tissues throughout their whole life, but besides plants specify new stem cells as part of their normal development to form lateral organs such as lateral roots. My previous research has identified a novel regulatory mechanism, the root clock (Moreno-Risueno et al. (2010) Science 329: 1306) that controls different developmental processes and by which root cells are selected to be specified as new stem cells in the model plant Arabidopsis thaliana. This research proposal focuses on understanding how new stem cell populations are selected and specified to become new stem cells by the root clock. In order to explore the transcriptional complexity and regulators that underlie this morphogenetic process I will use genomic, systems biology and genetic approaches. The results derived from this research will help to further understand the complex regulation that determines plant architecture and to establish paradigms of how stem cell specification and activity is controlled. Applications important for plant growth and nutrition, such as manipulation of anchorage, water and nutrient uptake, etc. may be derived from this basic research. The Curie Reintegration Grant would allow me to substantially improve the quality of the results, and subsequently the scientific quality and relevance of the research project. This would benefit my scientific career facilitating my lasting professional integration in the European Research Area, after my arrival from Duke University in USA. The activities derived from my research and integration, such as establishment of collaborations, transference of knowledge, and spread of my research results in scientific and public spheres, would contribute, in turn, to enhance the European scientific excellence.

Keywords: l312 stem cell biology,l310 developmental genetics - embryology in plants,l213 systems biology,l206 molecular genetics - reverse genetics and rnai
Novel bottom-up nanofabrication techniques for future carbon-nanoelectronics (NANOFAB4CNT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This research program aims at pioneering and developing new nanofabrication techniques for carbon-nanoelectronics using a so-called 'bottom-up' approach. Individual building blocks for carbon-based nanodevices, such as catalyst nanoparticles, horizontally aligned carbon-nanotubes and ultra-scaled contacts and dielectrics will be precisely placed directly on the chip, without the use of lithography. This will be accomplished by using unique combinations of electron-beam induced deposition (EBID), atomic layer deposition (ALD) and oblique ion beam treatments. The process development will go hand-in-hand with atomic level understanding of the developed processes using in-situ and ex-situ analysis techniques to ensure process reproducibility and selectivity. The need for new nanofabrication processes is a consequence of continuous down-scaling of electronic devices over the last 60 years for improved device performance. This continuous down-scalling will soon come to an end due to material limitations and the absence of viable processing techniques for even smaller nano-devices. On the materials side, carbon nanotubes (CNTs) and graphene hold great promise for next-generation nano-electronics due to their superior materials properties. However, for successful introduction of such carbon-based nano-devices in commercial products many manufacturing challenges need to be solved. Current 'top-down' electronics manufacturing techniques (e.g., materials patterning using photo- or e-beam lithography) will not be able to overcome these challenges. At the end of this research program a toolbox will be available with direct-write nanofabrication techniques that are universally applicable in any bottom-up nano-device manufacturing process. This toolbox will aid further scaling and improvement of future nano-electronic devices.

Keywords: g205 micro- and nanoelectronics - optoelectronics,c128 nanomaterials,p212 nanophysics,carbon nanotube,nano-engineering,bottom-up manufacturing,surface reaction mechanisms
Development of GlycoPhage Arrays as a novel high-throughput method for glycomics (GLYCOPHAGEAPP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Complex carbohydrates (glycans) are attached to proteins and lipids by the process of glycosylation and play important roles in many biological processes including cell-cell recognition, metabolic trafficking and host-pathogen interactions. Altered glycosylation or variations in the synthesis of glycans are known to cause diseases including cancer, retroviral infection and disorders of the heart, lung and blood. In order to establish connections between glycan structures and their functions (functional glycomics), to monitor glycosylation in disease diagnosis and prognosis, and to elucidate molecular mechanisms involved in pathogenesis, the development of precise, robust and sensitive methodologies for glycan analysis is critical. Carbohydrate-based arrays, or “glycoarrays,” have emerged in the last decade as a powerful tool, however to fully exploit the potential of arrays, it will be necessary to (i) increase the quantity and diversity of carbohydrate structures and (ii) develop reliable and reproducible chemistries for the immobilization of the carbohydrate probes onto solid support. Recently, the protein glycosylation locus (Pgl) discovered in Campylobacter jejuni was functionally transferred to E. coli, conferring ability to glycosylate proteins. Additionally, Dr. Celik has recently demonstrated glycosylation of phage particles simply by infecting the glycosylation competent E. coli with M13 phage displaying an acceptor protein. The hypothesis of this particular application is that the presentation of N-glycosylated proteins and O-antigens on phage particles can be exploited for the development of glycan arrays. The study will be significant because it will overcome the current bottlenecks in glycan array construction and provide a relatively inexpensive, specific and stable glycan representation method, as well as introduce a simplified and universal purification technique that is not dependent on the carbohydrate.

Keywords: l205 glycomics,g314 medical engineering and technology,l702 diagnostic tools,phage display,recombinant proteins,glycosylation,glycan array
Regulating the Mitochondrial Decision to Die (REMITODED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-12-01
End date: 2016-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The mitochondrial pathway of apoptosis is the major form of programmed cell death in vertebrates. In this pathway, pro-apoptotic members of the Bcl-2 protein family cause mitochondrial outer membrane permeabilisation (MOMP) leading to the release of mitochondrial intermembrane space proteins that activate caspase proteases and apoptosis. Regulation of MOMP has been intensively investigated because it represents a crucial, and potentially targetable, process that determines cell survival. Upon initiation, MOMP has previously been shown to occur synchronously and quickly in all mitochondria in less than ten minutes. However, using a new approach that mimics cancer cells that are primed to die, I find that the duration of MOMP can take over one hour in some cells (termed here slow MOMP). Importantly, cells that undergo slow MOMP fail to display overt signs of caspase activity and survive in the short-term, strongly indicating that caspase activity and kinetics of MOMP are tightly linked. My first objectives are to understand what controls differential MOMP kinetics and define how these regulate caspase activity and cell survival. Furthermore, I have recently found that some mitochondria can remain intact upon MOMP. This suggests that under normal or stressed conditions a minority of mitochondria can undergo MOMP without triggering apoptosis (termed here accidental MOMP). A second objective will be to investigate the occurrence of accidental MOMP and understand its impact upon caspase activity and cell viability. To meet both objectives I will use a variety of biochemical and cell biological methods including extensive and novel live-cell imaging techniques. This project will provide new insight into how MOMP and cell survival are regulated. It is expected that results and knowledge obtained from this work will contribute towards efforts to therapeutically target MOMP in various diseases such as cancer.

Keywords: l101 molecular biology and interactions,l304 apoptosis,l406 cancer and its biological basis,l306 organelle biology,l307 cell signalling and cellular interactions
A SOCIOLOGY OF INTERNATIONAL RELATIONS SCHOLARS AND SCHOLARSHIP IN THE UNITED KINGDOM (SOCIOLOGY OF UK IR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-07-01
End date: 2018-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 3
Project status: CLOSED

The proposed research is an in-depth sociological investigation of the production of knowledge in the field of International Relations (IR) in the United Kingdom. Its main objective is to understand how social, institutional and individual factors affect the production of IR scholarship and IR teaching in the country, as well as the dispositions, perceptions, and practices of IR scholars and their students. The research is informed by the theoretical framework developed by sociologist Pierre Bourdieu, which approaches knowledge as both a kind of cultural production and a form of social practice, that are embedded in objective socio-economic and ideational structures, while also being the product of individual and group dispositions capable of novelty and dissent. This praxeological approach allows the investigator to resort to a pluralist methodology, combining quantitative/statistical, historical, and thick ethnographic analysis, to investigate phenomena, structures, and processes that belong to three separate but interconnected levels of analysis: the systemic level of UK academia, the institutional level of departments of Politics and IR in the country, and the individual level of UK IR scholars and their post-graduate students. These levels will be investigated using a wide range of appropriate methods of inquiry, such as the collection of public data about educational policies and academic production, the analysis of responses to individual anonymous questionnaires, individual and group interviews, and on-site observations of academic practices and activities.

Keywords: international relations,sociology of science,sociology of knowledge,sociology of international relations scholarship,academic values,academic dispositions,academic production
Numerical modelling of smart energy harvesting devices driven by flow-induced vibrations (FSI-HARVEST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Luxembourg
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The project investigates a new class of piezo-electric energy harvesting devices for renewable energy resources. The key idea is to invert the traditional intention of engineers to avoid flow-induced excitation of structures such, that fluid-structure interaction can successfully be controlled and utilized in order to provide independent power supply to small-scale electrical devices. Possible application are e.g. micro electro-mechanical systems, monitoring sensors at remote locations or even in-vivo medical devices with the advantage of increased independence on local energy storage and reduced maintenance effort. This energy converter technology involves transient boundary-coupled fluid-structure interaction, volume-coupled piezo-electric-mechanics as well as a controlling electric circuit simultaneously. In order to understand the phenomenology and to increase robustness and performance of such devices, a mathematical and numerical model of the transient strongly-coupled non-linear multi-physics system will be developed and utilized for systematic computational analyses. On basis of numerical investigations of the overall system optimal designs of the flow-induced vibrating piezo-electric energy harvester are to identified with respect to electric power supply under varying exterior conditions. Vortex-induced excitations of a cantilever piezo-electric plate are exemplarily considered for studies on robustness and efficiency.

Keywords: g203 simulation engineering and modelling,g304 computational engineering
Neanderthal and Modern Human Adaptations in Eastern Europe (NEMO-ADAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-12-01
End date: 2016-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Modern human dispersal into Eurasia and the replacement of Neanderthals is one of the major issues in archaeological research. Particularly interesting is that modern humans were extremely successful in dispersing from Africa into virtually all parts of the planet. What behavioural adaptations contributed to their success? Are these adaptations unique to modern humans? What were the climatic conditions under which modern humans dispersed into Europe? Answering these key questions requires comparing the behaviour of the last Neanderthals and first modern humans in Europe, and placing these behaviours in an accurate climatic context. There is an urgent need for new, high quality datasets as much of the current debate deals with biased datasets from old excavations. Therefore, it is proposed here to survey and excavate new sites in four case-study regions in Eastern Europe (Ukraine and Russia). This project has two objectives: (1) the empirical creation of new scientific information and (2) the testing of models of modern human-Neanderthal interaction, modern human dispersal and colonisation processes. Objective 1 includes (a) characterisation of Neanderthal and modern human behavioural and cultural adaptations in the four case-study areas, (b) construction of a chronostratigraphic framework for the Late Middle and Early Upper Palaeolithic of these areas, and (c) reconstruction of palaeoclimate and palaeoenvironment to assess the conditions under which modern humans dispersed into Europe. Objective 2 seeks to test hypotheses and theoretical models of modern human-Neanderthal dynamics against these new data using a systematic, deductive approach. This project will contribute to a better understanding of the chronostratigraphic and climatic context of the modern human dispersal into Europe and the disappearance of Neanderthals. In so doing, it will reveal the behavioural underpinnings of the adaptive success, which allowed our species to eventually colonise the globe.

Keywords: s402 prehistory and protohistory,s401 archaeology - archaeometry - landscape archaeology
Drug adverse reactions predictability: exploring the mechanisms underlying the unexplained interindividual differences in drug metabolism and transport (DARMEC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Drug treatment is often inefficient. Only 30–60% of patients respond properly to treatment with e.g. antidepressants, beta-blockers, statins and antipsychotics. Furthermore, adverse drug reactions (ADRs) frequently occur and cause about 7% of all hospital admissions, a frequency that is increased to 30% in elderly subjects above 70 years of age. This is due to a great extent to pharmacokinetics differences. Epigenetic modifications have been demonstrated to potentially participate in the regulation of ~60 human ADME genes. A correlation between the gene’s epigenetic state and possible influence on drug therapy outcome has been experimentally established only in relation to a few ADME genes. Several drugs with epigenetic actions are currently used or on clinical trials. The best examples are DNA Methyltransferases (DNMTs) and Histone Deacetylase (HDACs) inhibitors. In this project, we propose to elucidate the substantial unexplained fraction of interindividual variability in drug response and metabolism using a 3D multi-cell in vitro model of human liver in comparison to transcriptome and phenotype data obtained from a bank of 130 human livers with the following AIMS: AIM1: to unmask the epigenetically regulated ADME genes AIM2: to evaluate the epigenetically regulated ADME genes as interindividual variability biomarkers A list of epimarks of interindividual variation of drug ADME processes will be generated. AIM3: to test the epigenetic influence of candidate drugs. Our objective is to identify the specific ADME genes epigenetically altered by each drug treatment and elucidate the possibilities of interindividual variation in the ADME processes for each of the tested drugs. This approach is extensively multidisciplinary and multisectorial. The experimental design includes tissue bioengineering techniques to develop liver organotypic cultures, drug metabolism functional profiling, and molecular biology approaches, from the perspective of cutting-edge technology.

Keywords: health sciences,adverse reaction,drug interaction,health & economic cost,organotypic culture,epigenetics,ncrna,industry transfer,clinical translation,career development,european excellence