Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An Adaptable Multiflow Diagnostic Platform to Genetically Identify Drug Resistant Infection (mfloDx)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-03-01
End date: 2023-08-31
Duration (months): 30.0
Total project cost (EUR): 3550750.0
EU funding (EUR): 2485525.0
Participants: 1
Project status: SIGNED

Tuberculosis (TB) kills more people than any other pathogen-borne illness; yearly, 10M people fall ill and 1.6M die. TB also contributes to a growing existential crisis: the spread of antibiotic resistant bacteria. Multi-drug-resistant TB is flourishing due to incomplete diagnoses and widespread prescription of ineffective antibiotics. Commercial diagnostics often require equipment in the €12-70K range and are either very slow or incomplete. As a result, less than one-third of new TB patients undergo strain testing to determine whether antibiotic resistance is present. mfloDx is a low-cost, DNA-based TB diagnostic, similar to home-pregnancy tests. In <3 h, our test identifies nearly 100% of drug resistant TB strains with 92-97% accuracy, directly from sputum samples and with a minimum of lab equipment or training. Clinical validation is ongoing and we are preparing for in vitro diagnostic (IVD) certification for an estimated launch in late 2022. The low cost, accessibility, and stability of mfloDx tests will enable uptake in developing countries, which are the source of much antibiotic-resistant infection. EMPE‘s team are experts in TB research, business development, and diagnostic tools for infectious disease. mfloDx grew from a molecular innovation called the Padlock probe, developed by our co-founder, Mats Nilsson. EMPE CEO Pavan Asalapuram combined this technology with a lateral flow biosensor, as a fast and accurate kit to identify antibiotic resistance. EMPE has raised ~€2M in seed capital and started clinical validations with partners in Spain and India. Thus far, our facility at Karolinska Institute Science Park produces test kits for research use only (RUO). EIC funding would accelerate clinical validation of our kits toward in vitro diagnostic certification and enable the implementation of large-scale production. This project will enable us to launch our top-of-the-line product and reach a worldwide €3.5B TB diagnostics market with WHO backing.

Keywords: tuberculosis,multidrug resistance,biosensors,antibiotic resistance,pandemics,nucleic acid testing
Targeting Tau-induced cognitive decline with antisense oligonucleotides to synaptogyrin-3 (TARGET_SYNAPTIC_TAU)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Belgium
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Tauopathies (that include Alzheimer’s disease) are characterized by hyperphosphorylation or mutations in the microtubuleassociated protein Tau. This reduces the affinity of Tau to bind microtubules and increases the levels of soluble detached Tau in neurons. Previous ERC-supported work from my lab showed that pathogenic Tau accumulates at pre-synaptic terminals and clusters synaptic vesicles in mouse and fly Tauopathy models and in Alzheimer patient brain samples. This pre-synaptic Tau reduces vesicle mobility and neurotransmitter release (Zhou et al., 2017). The interaction of Tau with synaptic vesicles occurs via the synaptic vesicle-associated protein Synaptogyrin-3. Lowering the levels of Synaptogyrin-3 blocks the ability of Tau to efficiently bind to synaptic vesicles (McInnes et al., 2018). Hence, Synaptogyrin-3 is a promising therapeutic target to tackle tauopathies. In this project I propose to use antisense oligonucleotides (ASOs) to reduce the levels of Synaptogyrin-3 in the brain of Tauopathy mouse models to rescue tau-induced pre-synaptic defects, including cognitive decline. ASO-technology has vastly improved over the past years and was recently approved to treat other degenerative disorders. My goal is to provide in vivo proof-of-concept that targeting Synaptogyrin-3 with an ASO in a therapeutic setting suppresses Tau-induced defects, including cognitive decline.

Keywords: synapse,neurodegeneration,animal model
Green and Smart Communications with Energy Harvesting: A Signal Processing Approach (GRENHAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

Efficient usage of energy resources is a growing concern in today's communication systems. Solutions that consider energy harvesting, where nodes in a communication system utilize other available energy sources, such as solar, wind power or man made signals, instead of completely relying on a fixed battery or the power from the grid, offer a promising perspective. Such approaches have a wide range of applications including wireless sensor networks, smart homes and smart cities. Understanding the information transfer capabilities of communication systems with energy harvesting features have been the attention of a number of recent works. At the moment the main line of research on the subject is typically done in an information theoretic framework with the rate maximization criterion. This line of work is important for understanding the fundamental limits in energy harvesting systems, yet it falls short in applicability in the context of practical scenarios. Here we propose an alternative estimation theoretic perspective where the problem is investigated within a practical signal processing framework. We will focus on efficient transmission and resource allocation strategies. Practical receiver structures with linear filtering, low complexity designs such as linear precoders, power allocation methods will be important ingredients in our work. The resulting solutions will complement the existing information theoretic solutions, and contribute to creating future green and smart communication systems.
Mastering the energetic particle distribution in a magnetohydrodynamic active plasma (FIREFELM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-08-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

FIREFELM – fast ions, radial electric field and edge localized mode – is an interdisciplinary project aimed at getting a better understanding of the basic mechanisms responsible for the energetic particle transport in fusion as well as in astrophysical plasmas making use of advanced diagnostic systems and state-of-the-art numerical tools. The main goal of this proposal is to control the dynamics between energetic particles, radial electric fields and magnetohydrodynamic (MHD) perturbations in the plasma edge and its impact on the overall plasma confinement. The mechanisms underlying the fast ion transport induced by MHD instabilities, such as Edge Localized Modes (ELMs) and externally applied Magnetic Perturbations (MPs) will be studied through innovative diagnosis techniques developed at the University of Seville and the Centro Nacional de Aceleradores (CNA) in Seville, Spain and employed in different fusion devices such as ASDEX Upgrade (Germany) and MAST Upgrade (UK). This project consists of three main research lines which follow a bottom up approach: the first research line is dedicated to fusion technology and aims at the development of the new generation of fast ion loss detectors (FILDs). New FILD systems will be able to provide absolute fluxes of escaping ions, their poloidal distribution and critical information on the wave-particle momentum and energy exchange. These advanced FILDs will be employed to characterize the interdependence between fast ion losses and radial electric fields and to study the role of fast ions in plasma edge stability and in the ELM cycle. Unraveling the interaction between MHD instabilities and energetic particles in tokamak plasmas will advance our understanding of the observed particle acceleration and transport in the solar corona and help to identify similarities between tokamak and astrophysical plasmas. This third research line will shed light on the anomalous heating of the solar corona and generation of the solar wind.

Keywords: plasma physics,solar physics,energetic particles,particle transport and acceleration,magnetohydrodynamics,electric fields,magnetic confinement
Biologically inspired chiral oxidation catalysts for commercial applications of fine chemistry (CHIROXCAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-05-01
End date: 2017-10-31
Duration (months): 18.0
Total project cost (EUR): 149750.0
EU funding (EUR): 149750.0
Participants: 1
Project status: CLOSED

The ERC-funded project BIDECASEOX ERC-239910 has produced a series of chiral catalysts with broad applicability in various commercial fields associated with synthetic organic chemistry. These catalysts are based in earth abundant metals and activate hydrogen peroxide to perform asymmetric introduction of oxygen atoms into readily available and cheap non chiral organic molecules, producing highly valuable chiral products, leaving water as the only byproduct. By virtue of these reactions, valuable chiral products that nowadays are only accessible by expensive enzymatic methods, or in some cases by toxic, expensive and large waste-producing traditional stoichiometric oxidants, become available in a sustainable manner. Pharmaceutical and agricultural industry, polymer chemistry and fine chemistry are envisioned as potential targets for the interest of the catalysts. With the aim of accelerating their access to the market, the present Proof of Concept (PoC) project, named CHIROXCAT, will target to study the feasibility of bringing these catalysts into a pre-commercial stage. This will be achieved by scaling-up current mg-scale synthetic methods, in order to establish economically optimized multigram scale procedures, and by validating their use in the production of representative chiral molecules of potential interest to the fine chemical industry. This PoC activity will also include an analysis of intellectual property (IP) protection needs within the field of application, as well as setting up the basis for any patent filling procedure required to provide an adequate protection of the catalysts and their uses. Moreover, a market study will be conducted to identify specific potential uses of these compounds, and a review of potential commercialisation partners will be carried out. The expected outcomes of the PoC project will be the commercial availability of a portfolio of chiral catalysts based in earth abundant metals with application in chemical

Keywords: homogeneous catalysis,fine chemistry,pharmaceutical industry,polymer industry,asymmetric oxidation,chiral catalysts,chiral roducts
Advanced Signalling, Automation and Communication System (IP2 and IP5) – Prototyping the future by means of capacity increase, autonomy and flexible communication (X2Rail-3)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Germany,Germany,Sweden,Switzerland,Belgium,Sweden,Sweden,Sweden,Belgium,France,France,France,France,Czechia,United Kingdom
Call: Advanced Signalling, Automation and Communication System (IP2 and IP5) (H2020-S2RJU-CFM-2018, 2018)
Start date: 2018-12-01
End date: 2021-11-30
Duration (months): 36.0
Total project cost (EUR): 23316426.54
EU funding (EUR): 17166487.4
Participants: 31
Project status: CLOSED

X2RAIL-3 represents the 3rd proposal of the Shift2Rail members in the IP2 “Advanced Traffic Management & Control Systems” domain and it aims to continue the research and development of key technologies within the following Technology Demonstrators (TDs): Adaptable Communications for all Railways (TD2.1 / WP3) – The objective is to demonstrate, via the integration of the different prototypes into dedicated demonstrators, that a new Communication System will be able to overcome the shortcomings in current ETCS and CBTC communications and deliver an adaptable communications system usable for train control applications in all market segments. Moving Block (TD 2.3 / WP4) – the scope is to move beyond the laboratory preparations undertaken in the framework of the X2Rail-1 project and to develop technical demonstrators for suitable railways applications. Zero On-Site Testing (TD 2.6 / WP5) – In the context of the simulation and testing framework integrating new functionalities such as moving block/satellite positioning, finalising the general architecture and will as well perform specific prototypes. Virtually Coupled Train Sets (TD 2.8 / WP6 & WP7) – The action aims to perform a comprehensive study focusing on the new concept of “Virtual coupling”, which foresees that trains will be able to run much closer to one another and to dynamically modify their own composition on the move. Cyber Security (TD 2.11 / WP8 & WP9) – In the context of Cyber Security, the main objectives are to define a “Cyber-Security” System to railway and to contribute to a secure development standard applicable to railway applications. ATO over ETCS pilot test for freight demonstrator (TD 5.6 / WP10) – In the context of freight autonomous train operation, the main objective is to perform field testing with specific focus on freight operational scenarios to get early feedback from the field on potential improvement necessities.

Keywords: zero on site testing,adaptable communication,moving block,cybersecurity,virtually coupled train sets,virtually coupling,ato over etcs goa2,pilot,demonstrator,prototype
Post-crisis urban transformations in Athens and Barcelona; a comparative approach (MATISSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-05-01
End date: 2021-08-29
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Nearly a decade after its outbreak, the shockwaves of the 2008 global crisis remain omnipresent in Southern Europe. Rapid political, economic and institutional transformations have triggered the reshuffling of housing. Within this framework, transnational investors are entering local property markets, purchasing repossessed houses and/ or non-performing loans. Spain and Greece, and their major cities Barcelona and Athens, are two outstanding but contrasting examples of this socio-political and spatial restructuring. They provide crucial theoretical, methodological and analytical challenges for urban studies and a key opportunity for the development of a novel comparative-relational approach to learn about the local consequences of the strategies of these global actors. The project MATISSE will address three lines of inquiry, looking into: (i) which are the policies encouraging housing financialisation (ii) who are the transnational investors and; (iii) which are the social and spatial implications of such property restructuring. It will bring together an interdisciplinary approach based on a two-way knowledge transfer between the ER’s (Dr Georgia Alexandri) existing research in urban restructuring in Spain and Greece with the Supervisor’s (Dr Stuart Hodkinson) extensive experience and research expertise in housing financialisation, privatisation and corporate mapping.

Keywords: city,southern europe,spain,greece,madrid,athens,post crisis social and spatial transformations
Zooming into the Population History of Iron Age Europe with Rare Genetic Variants. (MICROSCOPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1495161.0
EU funding (EUR): 1495161.0
Participants: 1
Project status: SIGNED

In recent years, archaeogenetic studies have yielded striking insights into European prehistory from ancient DNA. However, these studies focus on times prior and up to the Bronze Age, whereas more recent periods are still poorly covered. A key challenge with studying more recent time periods is the homogenisation of European populations since the late Neolithic, which exposes the limits of many existing analytical methods that try to detect population movements. To overcome these limits, in this proposal I will develop a genetic 'microscope', a new set of fine-scaled analytical methods based on rare genetic variation, which will allow us to analyse ancient genomic data to infer population structure with unprecedented detail. With this new toolbox, I will undertake the largest archaeogenetic investigation of the pre-Roman European Iron Age to date. A specific focus will be the ‘Celtic’ world, encompassing a core region spanning from parts of France into Slovakia, and which reached its maximum extent in the third century BC, spanning from the Iberian Peninsula to Anatolia. I will collaborate with a large number of partners from archaeology and anthropology, as well as genetic laboratories, to sample and analyse 600 skeletal remains from this region and time period. Using the new methods, I aim to investigate i) population structure during the early Iron Age in the 'Celtic' core region of Western and Central Europe; ii) the genetic evidence for the so-called 'Celtic migrations' from the third century BC, specifically by analysing samples from the Iberian Peninsula, Northern Italy, Hungary/Romania and the British isles; iii) how migration and population admixture are reflected at the community- and family level by ‘zooming in’ into selected archaeological sites to reconstruct family pedigrees. With new methodology, new reference data, and hundreds of ancient genomes from the pre-Roman Iron Age, this project will set new standards for archaeogenetic studies in Europe.

Keywords: archaeogenetics,population history
Accurate phylogenetic tree reconstruction using rate-heterogeneous birth-death models (PHYLOBD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Phylogenetic trees represent the evolutionary relationships among individuals, populations, or species. These trees also contain information on the evolutionary dynamics in the underlying population, and can be used in a wide range of applications, from studying the dynamics of an epidemic to analyzing the speciation and extinction dynamics of groups of species. Reconstructing phylogenetic trees from sequence data requires specifying a "tree prior", i.e. a model that represents a prior idea about the evolutionary dynamics. The adequacy of the tree prior influences the quality of the phylogenetic reconstruction, and consequently the quality of the inferred evolutionary dynamics. Unfortunately, the currently used priors are over-simplistic; in particular, they assume that evolutionary rates are constant in time and identical across lineages. These homogeneous tree priors are most often inconsistent with the model subsequently used to infer evolutionary dynamics, which is statistically problematic and likely to bias inferences. Several factors contribute to this issue: i) the computational challenges of carrying out "full phylogenetic inferences", that is analyses that co-estimate trees and dynamics, ii) the under-recognized influence of tree priors on phylogenetic reconstruction and subsequent analyses of evolutionary dynamics and iii) the lack of empirical guidance on the use and interpretation of rate-heterogeneous tree priors. PHYLOBD will address this issue and significantly improve full Bayesian phylogenetic inference by: i) providing efficient implementations of tree priors that account for rate heterogeneity across lineages ii) evaluating the importance of using such tree priors iii) providing tools for an accurate representation of rate-heterogeneous Bayesian posteriors, and iv) providing efficient implementations of full Bayesian phylogenetic inference when data are sampled through time.

Keywords: phylogenetics,bayesian inference,tree priors,birth death processes,lineage specific rates