Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Marketing Strategy Implementation as Source of Firms´ Competitive Advantage (IMS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,Austria
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

How can innovative marketing strategies be effectively implemented? While marketing scholars agree widely on the importance of effective strategy implementation for strategies’ performance outcomes, effective implementation of innovative marketing strategies and its relationship to firm performance is still not understood well. As a result, while firms invest significant amounts of resources in the implementation of their marketing strategies, many implementation initiatives fall far behind expectations and more often than not firms’ considerable investments in innovative strategies do not result, if at all, in notable effects on their performance. Against this background, the proposed research aims at investigating the effective implementation of innovative marketing strategies and how strategy implementation efforts affect both, the strategy-performance link and the sustainability of firms´ competitive advantage. Theoretically, this research is a much-needed step toward better understanding one of marketing´s key concepts (i.e., marketing strategy implementation). Given the scattered and fragemented research on the subject, the proposed research is likely to break ground for and inspire a systematic research stream on marketing strategy implementation in the future. From a managerial perspective, the findings will inform firms about effective ways to substantially improve the returns on their investment in innovative marketing strategies. As European firms must increasingly focus on the development of innovative marketing strategies to excel on global markets, this knowledge will help them to gain and sustain leading positions on their markets—and prevent them from having great strategies, but nevertheless failing on the market.

Keywords: marketing,strategies,implementation
Strengthening sensor research links between the Georgian Technical University and the European Research Area (SENS-ERA)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Georgia,United Kingdom,Luxembourg,Greece
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2011-12-01
End date: 2013-11-30
Duration (months): 24.0
Total project cost (EUR): 522540.57
EU funding (EUR): 466907.0
Participants: 5
Project status: CLOSED

The overall aim of the SENS-ERA project is to integrate the Georgian Technical University (GTU) into the European Research Area (ERA), by developing cooperation with European research and innovation organisations in its 3 strongest research topics: A) Semiconductor based materials for optical sensors; B) Radiation sensor elements based on A4, A3B5, and rare earth semiconductors; C) Novel smart sensor systems for environmental monitoring. These are research topics highly relevant to the FP7 ICT, NMP, Security and Environment work programmes. GTU was established in 1922 and is the leading technology university in Georgia. It is also an important research centre in the South Caucasus and Black Sea region and many GTU graduates have gone on to become high-ranking scientists and engineers around the world. The SENS-ERA project will build upon GTU’s existing strengths as a high-quality research institution via capacity building activities with the following 3 excellent European research and innovation organisations: 1. Cranfield University (Cranfield), 2. Technological Educational Institute of Piraeus (TEIPIR), 3. Intelligentsia Consultants (Intelligentsia) The capacity building activities will involve twinning and training of GTU researchers focused on the three research topics as well as the FP7 programmes (e.g. ICT, NMP, Security and Environment). Also, it will involve dissemination and strategy development to support the GTU organisation. The SENS-ERA project will be overseen by a steering committee involving the consortium partners plus members of the Georgian government, Euroscience Association and Euro Mediterranean Academy of Arts and Sciences. The regional economic and social impacts expected from the SENS-ERA project are precisely the reasons why many of these organisations have signed letters of support for this proposal.

Keywords: sensors,semiconductor based materials for optical sensors,radiation sensor elements based on a4,a3b5,and rare earth semiconductors,novel smart sensor systems for environmental monitoring
Cultural and Biological Bases of Language Evolution (LANGEVO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The origins and evolution of human languages remains today one of the most fascinating unresolved puzzles of science and many disciplines are currently working on the subject. Computer scientists have also become involved, trying to program artificial agents in such a way that they are able to self-organize a language-like system from scratch. There are already some successful simulations. They endow agents with language strategies in the form of networks of embodied cognitive functions for producing, comprehending, learning and aligning some aspect of language, for example to express participant roles in events using a case grammar. The present project goes one step further and inquires about the origins of these language strategies and how they can become shared in a population, based on the hypothesis that language strategies form in each individual by the epigenetic recruitment and exaptation of distributed networks, which support the strategies culturally emerging in a population. The project will develop the computational foundations for this ‘recruitment theory of language origins’, engage in simulations and robotic experiments, and validate them from a linguistic and biological point of view. It will look at the genetic bases of language by conducting Genome-wide Association Studies correlating phenotypic variation in linguistic aptitude, particularly for language learning, with genetic markers. At the end of this interdisciplinary project a more encompassing picture of language evolution should begin to emerge, illuminating the cultural, cognitive and genetic factors that have played a role in the origins and evolution of language.

Keywords: evolutionary biology,cognitive science,historical linguistics,artificial intelligence,robotics
A Cross Species Approach to Understand the Mechanism and Evolution of Limb Regeneration Capacity (REGENERATEACROSS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: Germany
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-06-01
End date: 2017-12-31
Duration (months): 67.0
Total project cost (EUR): 2447600.0
EU funding (EUR): 2447600.0
Participants: 2
Project status: CLOSED

Limb regeneration capacity varies among vertebrates, ranging from full regeneration in salamanders, to stage-restricted premetamorphic regeneration in frogs, to finger-tip regeneration in newborn mice and humans. The molecular and cellular basis for these differences in regeneration ability is not known and it is still unclear if these different regenerative events are tied by some common mechanisms with progressive restriction due to extracellular signals or cell intrinsic changes. Connective tissue fibroblasts or their progenitors play a key role in regenerating the patterned salamander limb. They harbor critical positional information and can reconstitute not only the connective tissue but also a complete, patterned skeleton. In contrast, such cells typically contribute to scar tissue during mammalian wound healing. Their role in mouse finger tip regeneration is unknown. I seek to determine the differences in fibroblast biology that account for the differences in regeneration between salamander, frog and mouse. To define the differences in composition of the connective tissue population, I will perform parallel lineage tracing of different fibroblast populations and their progenitors during wound healing and regeneration in salamander, frog and mouse. To determine differences in cell intrinsic potential versus extracellular cues required for regeneration I will perform cross-species transplantation of lineage-labeled cells between salamander and frog coupled with expression profiling to identify molecular changes that occur in cells in a regenerative versus non-regenerative context. Finally I will use this expression profiling and our molecular knowledge of limb regeneration factors to test whether frog and mouse cells can acquire regenerative traits at the cellular level by the forced exposure to intracellular and extracellular regeneration cues or by the downregulation of putative inhibitory factors.

Keywords: limb regeneration,reprogramming,fibroblast
Assembling biomembranes: fundamentals of membrane transporter folding and creation of synthetic modules (MEMSEMBLE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: United Kingdom,United Kingdom
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-05-01
End date: 2018-04-30
Duration (months): 72.0
Total project cost (EUR): 2312389.0
EU funding (EUR): 2312389.0
Participants: 2
Project status: CLOSED

Self-assembly is a hallmark of Biology. We are far from a complete understanding of this natural assembly, which in turn limits our ability to mimic biological construction in the bioengineering of tuneable synthetic systems. This proposal addresses the major challenge of membrane protein folding. Here, I intend to make a step change to my pioneering biophysical studies and investigate co-translational membrane protein folding. A central feature will be the creation of synthetic systems to probe key events in co-translational folding, as the protein folds in the membrane whilst emerging from the ribosome. An ambitious target is to make these systems tuneable, which will provide a new tool for the fabrication of membrane proteins and artificial cells in Synthetic Biology. The assembly of a tuneable artificial module that affords control over membrane protein synthesis is unprecedented. I focus on the ubiquitous superfamily of major facilitator proteins, namely the best studied family member, lactose permease, LacY. This proposal has state of the art biophysical mechanistic studies at its core, which interleave into Cell and Synthetic Biology. There are two themes: Theme 1. Determination of fundamental membrane protein folding parameters: folding transition states and lipid control Phi-value analysis will be used to probe the folding transition state of LacY; the first such analysis of a multi-domain membrane protein. Lipid parameters that control LacY folding will be quantified, including bilayer asymmetry using novel droplet interface bilayer methods. Theme 2: construction of tuneable synthetic co-translational folding systems Engineered ribosomes and translocon insertion machinery will be incorporated and LacY folding will be controlled. Translation will be regulated or halted using mutant ribosomes, arrest sequences, altered codon usage and controlling tRNA addition. Trapped LacY folding intermediates will be studied using biophysical methods.

Keywords: membrane protein,folding,co-translational,major facilitator,membrane transport,transition state
RNA poly(A) tail: the beginning of the end (DEAD2THEEND)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-04-01
End date: 2017-03-31
Duration (months): 60.0
Total project cost (EUR): 2499344.0
EU funding (EUR): 2499344.0
Participants: 1
Project status: CLOSED

The degradation of mature mRNAs has emerged as a key step in the regulation of eukaryotic gene expression. Modulation of the half-life of mRNAs via their degradation is a powerful and versatile mechanism to swiftly alter the expression of proteins in response to changes in physiological conditions. The decay of mRNAs is performed by a set of macromolecular complexes that act in a sequential and coordinated manner, progressively eroding the ends of the transcript until its degradation is complete. These macromolecular assemblies contain only a few catalytically active subunits and a large number of regulatory components. How and why the activities are regulated within the architecture of the complexes is largely unknown. Also unclear are the mechanisms with which the complexes communicate with each other and/or with the changing composition of the nucleic acid. In this project, we will reconstitute the key protein complexes in mRNA decay from recombinant proteins in vitro. Specifically, we will focus on the evolutionary conserved deadenylation, decapping and exosome-Ski complexes. The reconstituted complexes will be used for structural studies to derive atomic models of the holoenzymes using a combination of X-ray crystallography and cryoelectron microscopy. In parallel to obtaining static views of the individual steps in the pathway, we will establish the assays to study how information from one processing step is passed on to the next in a dynamic manner. We will address the basis for the timing and interrelationship of the conserved enzymatic machineries and the influence of the mRNP composition on their activity. Our final goal is to recapitulate the complex behavior of the mRNA decay pathway in vitro. Our lab has extensive experience in biochemical reconstitution of protein complexes, in vitro biochemical assays and X-ray crystallography. In the next five years, we plan to implement cryoelectron microscopy within the scope of this proposal.
Dynamics of local transcriptomes and proteomes in neurons (NEURONAL DYNAMICS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: Germany
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 2402134.4
EU funding (EUR): 2402134.4
Participants: 1
Project status: CLOSED

The ability of the nervous system to respond adaptively relies on modifications to existing proteins as well as changes in gene transcription and protein translation. An individual neuron in the brain possesses approximately 10.000 synapses, many of which are hundreds of microns away from the cell body. As many of the changes to environmental stimuli occur at synapses, the question arises as to how the modified synapses gain access to the new mRNAs and proteins. It is now clear that synapses possess the capacity for local protein synthesis, owing to the localization of ribosomes and mRNAs within dendrites. Previous studies have identified a relative small number of localized mRNAs and an even smaller number of locally synthesized proteins. We hypothesize that synaptic plasticity makes use of the local pool of mRNAs and newly synthesized proteins to alter its’ function. Here we propose to discover the identity of nearly all the mRNAs that are localized, “the local transcriptome”, using the deep RNA sequencing technology. Using a new high-resolution platform that makes use of “fluorescent barcodes” we will visualize individual mRNAs and quantify their abundance in the dendrites. We will also discover the proteins that are synthesized in dendrites, “the local proteome”, using a novel chemical tagging strategy that we developed. In this approach, we can identify proteins synthesized within a given cell-type (e.g. neurons), via the expression of mutant tRNA synthetase in a restricted cell population. We will then examine how plasticity sculpts the local mRNA and protein population, as we hypothesize that both the transcriptome and the proteome are dynamically regulated by ongoing synaptic events.

Keywords: synpase,cell biology,neuronal protein synthesis,dendrite,mrna trafficking,neuronal transcriptome,neuronal proteome
Sensitive, specific high-throughput plasma proteome analysis via ProteinSeq (PROTEINSEQ)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Sweden
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-03-01
End date: 2017-02-28
Duration (months): 60.0
Total project cost (EUR): 2499600.0
EU funding (EUR): 2499600.0
Participants: 1
Project status: CLOSED

Despite increasing interest in biomarkers to diagnose and distinguish diseases and select treatment few new protein biomarkers are being successfully validated. Important explanations for the limited success are poor specificity and sensitivity of detection of plasma proteins using current assays, and inability to analyze large numbers of markers and samples. Improved assays should provide access to plasma protein biomarkers at levels below current detection thresholds, potentially reflecting disease processes anywhere in the body at early stages. They should also distinguish closely similar protein variants. The assays should furthermore assess numerous markers in parallel with limited consumption of biobank samples. The aim of this project is to enable investigations of protein biomarkers at entirely new levels of performance. The basis of the proposal is our expertise in molecular tools and specifically an approach to protein analysis that addresses the above requirements. This technology is now ready to be scaled for large-volume, high-performance assays with the following characteristics: 1) Unsurpassed specificity via simultaneous detection of three epitopes on any target protein. 2) Amplifiable DNA strands form upon specific detection, permitting ultrasensitive detection. 3) Only appropriate reagent combinations result in amplifiable reporter strands, overcoming obstacles to multiplex protein detection. 4) Tag sequences in the amplified DNA strands identify the detected proteins and the investigated samples, allowing digital information of protein abundance to be retrieved via next generation DNA sequencing of multiplex reactions for large numbers of patients in single runs. I propose to set up and apply assays of a thousand proteins in parallel in small plasma samples, and in a subproject I will target proteins on a novel and promising class of cancer biomarkers – exosomes.

Keywords: proximity ligation assay,diagnostics,proteomics,plasma sample,antibody,recognition,specificity,biomarkers,prostasomes,exosomes,next generation sequencing
COVALENT SINGLE-MOLECULE CHEMISTRY OF THE CELL (COSIMO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: United Kingdom
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-04-01
End date: 2017-03-31
Duration (months): 60.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

A label-free single-molecule technology developed the PI's laboratory will be exploited to elucidate covalent chemistry of relevance to the cell. The approach uses an engineered protein pore that passes a non-perturbing current carried by aqueous ions. Covalent bond making and breaking events within this nanoreactor are registered as step changes in the ionic current that reveal the kinetics of each reaction step. No perturbing reagents, such as fluorophores, are required. Single-molecule chemistry provides insights that are not forthcoming from ensemble experiments. For example, all the intermediates in a reaction are revealed in the correct sequence; a fast step that follows a slow step is readily observed; branched pathways can be dissected. We have demonstrated the feasibility of the nanoreactor approach and now we will build on its considerable potential by deciphering and quantifying three aspects of cellular chemistry that encompass basic science and biotechnology: 1. various reactions that occur in cells and tissues (e.g. nitrosothiol second messenger chemistry); 2. the chemistry of reagents for use in cell biology (e.g. the site-specific attachment of fluorophores to proteins); 3. the development of single-molecule sensors for cells and tissues (e.g. sniffer pipets).
The evolution and development of cooperation in mammalian societies (THCB2011)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Evolutionary, population and environmental biology
Countries involved: United Kingdom
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-07-01
End date: 2018-06-30
Duration (months): 72.0
Total project cost (EUR): 2497442.8
EU funding (EUR): 2497442.8
Participants: 1
Project status: CLOSED

The aim of this project is to understand the distribution and evolution of cooperative behaviour and social organisation in mammals. One component of the project will focus on interspecific differences and will use a recently developed, gene-based phylogeny to reconstruct the evolution of social organisation and cooperative behaviour while a second will use detailed studies of two mammals where cooperation is highly developed (Kalahari meerkats and Damaraland mole-rats) to investigate the causes and consequences of individual differences in cooperative behaviour and the mechanisms that affect them. The project will provide insight into the evolution of animal societies and the origins of human social behaviour.

Keywords: cooperation and development