Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Research Infrastructure Services for Climate Change risks (IRISCC)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: Research and Innovation actions
Countries involved: Finland,Netherlands,Greece,France,Norway,Bulgaria,Denmark,Portugal,Italy,Spain,Sweden,Belgium,Germany,Czechia,Austria,Hungary,Israel,United Kingdom,Romania,Cyprus,Poland
Call: Research infrastructure services to enable R&I addressing main challenges and EU priorities (HORIZON-INFRA-2023-SERV-01, 2023)
Start date: 2024-04-01
End date: 2028-09-30
Duration (months): 54.0
Total project cost (EUR): 14499858.05
EU funding (EUR): 14499857.75
Participants: 80
Project status: SIGNED

Adaptation to climate change requires in-depth understanding of climate change driven risks, including their determinants (hazards, exposure and vulnerabilities) and impacts to human, production and natural systems. Integrated Research Infrastructure Services for Climate Change Risks (IRISCC) is a consortium of diverse and complementary leading research infrastructures (RIs) covering disciplines from natural sciences to social sciences, across different domains and sectors. IRISCC provides scientific and knowledge services to foster cutting-edge research and evidence-based policymaking to improve Europe's resilience to climate change. IRISCC ensures a “one-stop-shop” for various user communities on climate change risk related RI services by setting up a dedicated Catalogue of services and related access management system both for granting transnational (onsite and remote) and offering virtual access. The Catalogue of services will be built through three consecutive releases, each delivering increasingly integrated services to its user communities. The IRISCC service integration will include Service Design Labs employing co-design and transdisciplinary action, and Service Demonstrators benchmarking the integrated cross-RI services. In addition to services aimed towards the scientific community, IRISCC will offer knowledge services aimed towards policymakers and other stakeholders. This is done together with risk management platforms. The research enabled by IRISCC contributes to future reports on climate change effects (IPCC, IPBES) as well as policy- and decision-making to meet the targets of climate adaptation strategies. IRISCC contributes to training a new generation of scientists to efficiently use RI services and for data stewardship. Data from IRISCC will be open and made available in compliance with FAIR principles and linked to European initiatives such as EOSC. Strong links will be created between IRISCC and current and future efforts under Horizon Europe.

Keywords: research infrastructure,climate change,risk,hazard,exposure,vulnerability,interdisciplinary,trans disciplinary,catalogue of services,transnational access,virtual access,training
Mitochondrial signaling drives parasite differentiation (MitoSignal)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Czechia
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1991125.0
EU funding (EUR): 1991125.0
Participants: 1
Project status: SIGNED

Mitochondria perform three essential functions: ATP production, metabolite synthesis and cellular signaling. These signals, communicating the bioenergetic and biosynthetic fitness of the organelle to the nucleus, play a powerful role in determining cellular fate. The incorporation of mitochondrial reactive oxygen species (mROS) in cellular signaling is an interesting evolutionary outcome, as excess levels of these potent oxidizers have been implicated in many pathologies. While most research focuses on these outcomes of oxidative stress, much less is known about how mROS drive a range of physiological responses. Furthermore, the available studies are limited to a few traditional model organisms, featuring complex cellular systems with numerous mitochondria at different energetic states. Here, we propose to utilize the unicellular parasites, Trypanosoma brucei and T. congolense, as simplified but elegant models to define mROS-driven cellular differentiation. As these protists undergo programmed development between several distinct life cycle forms, there are striking changes to the structure and physiology of their single mitochondrion that manifest in elevated ROS levels. Importantly, we demonstrated that these ROS molecules are essential for the developmental progression of the parasite. Employing these well-chosen models and combining next-generation biosensors, advanced bioenergetic methods, redox proteomics and a CRISPR/Cas9 genetic screen, we will answer the following fundamental questions: Does mROS drive Trypanosoma cellular differentiation? What molecular processes are responsible for the elevated mROS levels during differentiation? How is the redox signal propagated to the rest of the cell? The proposed research aspires to unravel the fundamental mechanisms underlying the intricate communication between mitochondria and the rest of the cell, featuring cellular hallmarks of cell fate decisions.

Keywords: trypanosoma,differentiation,life cycle,mitochondrion,reactive oxygen species,electron transport chain,metabolism,bioenergetics,proteomics,
EIT InnoEnergy Business Plan 2023 - 2024 (KIC SE BP2023- 2024)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: EIT InnoEnergy
Destination: EIT InnoEnergy
Action type: Knowledge and Innovation Communities
Partnership: EIT InnoEnergy (EIT KICs)
Countries involved: Netherlands,United States,Spain,Sweden,Germany,Poland
Call: EIT InnoEnergy Business Plan 2023-2024 (HORIZON-EIT-2023-2025-KIC, 2023)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 47991636.73
EU funding (EUR): 47991636.73
Participants: 7
Project status: CLOSED

EIT InnoEnergy is synonymous with innovation and entrepreneurship in the field of sustainable energy. It is achieving this by leveraging the potential of the knowledge triangle: higher education, research, and industry throughout Europe, and globally. For EIT InnoEnergy, sustainability in energy means aligning with the Energy Union strategy, contributing to three objectives: (1) Decrease the cost of energy (€/kWh), (2) Increase the security of the energy system (operability of assets and autonomy in supply), and (3) Reduce greenhouse gas emissions. We operate three business lines: (1) the Education Programmes, which create and accompany the future significant changes in sustainable energy; (2) the Innovation Projects, which focus on producing incremental and disruptive technological and business model innovations; (3) the Business Creation Services(entrepreneurship), where we nurture innovative start-ups and grow small enterprises in sustainable energy. These business lines are supported by the management and operations activities. EIT InnoEnergy is also orchestrating three industrial strategic value chains on batteries and Photovoltaic (PV) through the European Battery Alliance and European Solar Initiative, formally mandated, and endorsed, respectively, by the European Commission in 2017 and 2020. EGHAC (European Green Hydrogen Acceleration Center) is the third one on green hydrogen, implemented together with Breakthrough Energy. All our activities focus on six thematic fields (Smart Grids, Storage, Smart Cities and Efficient Buildings, Energy from Chemical Fuels, Renewables and Energy for Transport) that evolve with the energy market changes and are fully aligned with the European Union Energy Strategy and the NECP (National Energy and Climate Plans). EIT InnoEnergy will fully comply with the EIT Financial Sustainability principles, KIC fund principles, Innovation Principles, EIT RIS Hub Minimum Standards and Good Governance principles.

Keywords: energy,innovation,impact,trusted ecosystem,strategic value chains,industrial projects,start up support,education,sustainability
Metabolism-YEATS-crosstalk: Elucidating metabolic dependencies of epigenetic YEATS action (M-Y-cro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 262287.09
EU funding (EUR): 183600.96
Participants: 1
Project status: CLOSED

Metabolism and gene regulations act in concert to shape cellular identity and plasticity. One major line of crosstalk occurs through metabolites such as acyl-CoAs, which are inscribed on histones as posttranslational modifications (PTMs) to be subsequently recognised by reader proteins, resulting in initiation of specific transcriptional programs. The increasing identification of novel PTMs necessitates thorough characterisation, however still remain largely underexplored. For instance, the presence of non-acetyl acyl-Lys PTMs such as crotonylation with YEATS-reader proteins identified to bind these PTMs suggests complex gene regulation programs. However, despite the clinical relevance of YEATS-proteins in various cancers, little is known about their acyl-reading activity and transcriptional consequences. Therefore, this proposal aims to close multiple knowledge gaps regarding overall function and mechanism of the metabolism/acyl-PTM/YEATS communication axis. Considering the metabolic context, I furthermore propose epigenetic YEATS action to be determined by direct interactions with metabolic proteins. Thus, I will first establish an inducible YEATS-degradation platform to characterise the genomic context under various acylate conditions. Next, I will implement a fluorescence-based cell reporter system, which shall reveal putative interactors upon transfection with a CRISPR-KO library targeting metabolic enzymes. Lastly, hits will be biophysically characterized, their metabolic impact within the epigenetic context determined and co-dependencies on relevant cancer cell lines tested. The interdisciplinary approach entailing state-of-the-art chemical and molecular biology tools will be combined with high-throughput screening methods and bioinformatic analyses. Besides elucidating general principles of the metabolism-YEATS epigenetics crosstalk, the results will provide valuable information for novel therapeutic avenues by exploiting identified co-dependencies.

Keywords: nuclear metabolism,cell line engineering,histone readers
PREVENTIVE PROTECTION OF ARCHAEOLOGICAL SITES IN THE EMMENA REGION (REVITALISER)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus,Italy,Netherlands,Spain
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 1498056.25
EU funding (EUR): 1498056.25
Participants: 5
Project status: SIGNED

The REVITALISER's primary goal is to boost the capabilities of the ECoE to develop skills tailored for the protection of archaeological sites from illegal excavations and looting activities in the EMMENA Region. Through strategic networking activities between the ECoE and three internationally leading institutions (BSC, FBK, UM), REVITALISER aims to achieve four main objectives: • Improved excellence capacity and resources of ECoE to bridge the research and innovation divide between Cyprus and Europe in Earth Observation and Cultural Property Protection (CPP) and archaeological looting, utilizing an interdisciplinary approach encompassing archaeological aerial interpretation, AI, machine learning, law, policy, and criminology. • Raised reputation, research profile, and attractiveness of the ECoE for junior and senior qualified researchers (inwards and outwards mobility) active in CPP, together with the boosted profile of its scientific staff involved in the cultural heritage domain. • Strengthened research management capacities and administrative skills of the ECoE staff, through capacity-building activities in project management, funds acquisition, talent attraction and retention, and dissemination strategies, among others. • Improved creativity of the ECoE researchers in CPP supported by REVITALISER exploratory research project, fostering knowledge exchange, collaboration, and new avenues of research, exploiting the advanced partners' expertise and solid network. Ultimately, the ECoE, enriched by the REVITALISER Twinning experience, will become a leading institution in archaeological protection, focusing on combating cultural property crimes in the EMMENA region, making meaningful advancements in the preservation of cultural heritage.

Keywords: archaeology,heritage,remote sensing,artificial intelligence,criminology
TWINNING MICROPLASTIC-FREE ENVIRONMENT (GREENLand)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,Germany,Ireland
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1498660.0
EU funding (EUR): 1498660.0
Participants: 3
Project status: SIGNED

GREENLand is an innovative strategy for transforming to a digital Cloud-Based System with the education of staff for research of microplastics in soil, water, and microorganisms, as well as networking with the excellent institutions and stakeholders who are interested in the results of scientific research. The essence of GREENLand is to change the system in which a great contribution will be made to the planet without plastic by working on preventive measures, innovations, and a plan for remediation. Trained professional staff will be able to be more efficient with the help of new digital tools, which will result in the establishment of strong cooperation with institutions and industry.

Keywords: microplastics,transformation,e tools,strategic networking,and staff exchange
TRUstworthy Multi-site Privacy Enhancing Technologies (TRUMPET)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Spain,Israel,France,Italy,Belgium,United Kingdom,Türkiye
Call: Scalable privacy-preserving technologies for cross-border federated computation in Europe involving personal data (HORIZON-CL3-2021-CS-01, 2021)
Start date: 2022-10-01
End date: 2025-12-31
Duration (months): 39.0
Total project cost (EUR): 4243347.5
EU funding (EUR): 4243347.5
Participants: 10
Project status: SIGNED

In recent years, Federated Learning (FL) has emerged as a revolutionary privacy-enhancing technology and, consequently, has quickly expanded to other applications. However, further research has cast a shadow of doubt on the strength of privacy protection provided by FL. Potential vulnerabilities and threats pointed out by researchers included a curious aggregator threat; susceptibility to man-in-the-middle and insider attacks that disrupt the convergence of global and local models or cause convergence to fake minima; and, most importantly, inference attacks that aim to re-identify data subjects from FL’s AI model parameter updates. The goal of TRUMPET is to research and develop novel privacy enhancement methods for Federated Learning, and to deliver a highly scalable Federated AI service platform for researchers, that will enable AI-powered studies of siloed, multi-site, cross-domain, cross border European datasets with privacy guarantees that exceed the requirements of GDPR. The generic TRUMPET platform will be piloted, demonstrated and validated in the specific use case of European cancer hospitals, allowing researchers and policymakers to extract AI-driven insights from previously inaccessible cross-border, cross-organization cancer data, while ensuring the patients’ privacy. The strong privacy protection accorded by the platform will be verified through the engagement of external experts for independent privacy leakage and re-identification testing. A secondary goal is to research, develop and promote with EU data protection authorities a novel metric and tool for the certification of GDPR compliance of FL implementations. The consortium is composed of 9 interdisciplinary partners: 3 Research Organizations, 1 University, 3 SMEs and 2 Clinical partners with extensive experience and expertise to guarantee the correct performance of the activities and the achievement of the results.

Keywords: federated learning,privacy enhancing technologies,secure multiparty computation,differential privacy,homomorphic encryption,privacy metrics,gdpr,privacy preserving cross border learning
The Cartography of the Political Novel in Europe (CAPONEU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Croatia,Germany,Poland,United Kingdom,Cyprus
Call: The role of perceptions, formed by traditions, values and beliefs, in shaping European societies and politics in the 21st century (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 1866039.0
EU funding (EUR): 1864789.0
Participants: 8
Project status: SIGNED

The project sets out to examine how people in different national and cultural contexts engage with contemporary political issues and thereby have their share in shaping European societies and politics in the 21st century. This is done through the prism of an extraordinary aesthetic and social phenomenon that we call the political novel in Europe (or PNE), which is gaining prominence not only in strictly delimited literary circles but in European societies at large. Given this new relevance of political writing, CAPONEU’s goal is to assess the political novel as an important element of the European cultural heritage and as a tool for community building and European advocacy. The consortium brings together an interdisciplinary research team that seeks not only to unpack the rich literary heritage of the 20th century but also (through collaboration with a wide range of actors) to make the PNE experiences relevant to our present. It allows us to understand how perceptions formed by different beliefs, values, traditions, economy, history, culture, age and gender are reflected in the PNE as a specific literary genre, and how and why this genre re-emerges as a social factor today. Thus, not only the representation of beliefs and traditions in the PNE will be analysed, but also the role of the PNE itself in shaping and changing perspectives on the individual, the state, the economy, and especially on Europe’s historical and cultural past. Aware that the European project has been destabilised in recent decades by crises (economic and political crises, migrations, the COVID-19 pandemic and climate change), the question now is how the European heritage of the EPN can become active in strengthening the resilience of European societies to crises. Given the simultaneous resurgence of various forms of populism and/or authoritarianism, a subsequent recession, and, most recently, war with unpredictable consequences, answering this question will be crucial for the future of Europe.

Keywords: literary heritage,politics of literature,political novel,politics,educational policy,reading communities,literary cartography
TurnUp – AI Deeptech Platform Against No-Shows with Real-Time Optimization and Generative Assistance (TurnUp)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

TurnUp is a European deeptech platform tackling one of the largest inefficiencies in healthcare and services: missed appointments and last-minute cancellations. Unlike traditional tools that only send reminders, TurnUp predicts which bookings are at risk of no-show and instantly reallocates freed slots to someone from the waitlist. This ensures no valuable capacity is lost while patients and customers gain faster access to care, beauty, or hospitality. At its core, TurnUp combines a predictive algorithm with a real-time optimization engine, designed to handle complex behavioral data and fairness rules. In addition, we are developing an AI generative assistant (“co-pilot”) that automates routine front-desk tasks such as confirmations, rebookings, and customer communication, freeing staff to focus on higher-value work. TurnUp is already live in over 100 Belgian practices (TRL 6) and currently piloting in the Netherlands and United Kingdom, with Italy as a potential next step. Our ambition is to become the European standard for intelligent scheduling: preventing millions of no-shows, increasing efficiency in healthcare and service industries, and reducing waste of time, resources, and energy. With EIC support, we will advance our deeptech capabilities (federated learning, bias control, patent filings) and accelerate scale-up across EU markets.

Keywords: appointment optimization no show reduction ai scheduling generative assistant healthcare efficiency federated learning digital health deeptech europe