Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dual-channel paper-based electroanalytical platform for multiple myeloma care (PADMME)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Romania
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 133735.68
EU funding (EUR): 133735.68
Participants: 1
Project status: CLOSED

Multiple myeloma (MM) is an aggressive type of cancer of plasma cells where fast diagnosis and treatment monitoring is vital, especially given the overall low survival rate. Proteasome, a multi-catalytic complex essential in damaged protein degradation, has been recently established as a biomarker for MM, in which elevated levels have been observed in blood plasma of unhealthy individuals, as well as its impaired activity has been target for treatment alongside regular chemotherapy. PADMME addresses increasing contributions on proteasome electrochemical recognition and aims to develop novel interdisciplinary technologies translatable into POCT systems for MM care. For this, we propose the development of sensitive and selective dual-channel platforms comprising conductive polymeric fiber biosensors integrated on paper-based microfluidic supports to simultaneously detect quantity and specific activity of proteasome in blood plasma. Paper supports ensure disposability and ease of commercialization, whilst incorporation of microfluidic paths allows low sample volume requirements and in situ pre-treatment steps. Conductive polymeric fiber scaffolds provide increased signal resolution for the construction of biosensors, necessary for the recognition of low concentrations of the biomarker. Then, investigating proteasome at the dual-channel platform in drug-treated and untreated MM cell lines will demonstrate how changes in quantity and specific activity are specifically linked to the disease dynamics. The last step will comprise validation of the technology for analysis in blood plasma, technology able to improve overall monitoring of MM disease progression and therapeutic efficiency, crucial to overcome delays in treatment due to drug resistance complications. Training through research will allow me to refine my expertise, creativity and innovative potential on smart biosensor technologies translated into point-of-care testing devices for cancer care and drug assessment.

Keywords: proteasome,biosensor,electrochemistry,bioelectrochemistry,biomarker,multiple myeloma,paper,microfluidic
Specific Grant Agreement n°1 to Scale the Cities Mission Platform (SGA-NZC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,France,Ireland,Spain,Netherlands,Finland,Italy,Estonia,Sweden,Poland,Switzerland
Call: Specific Grant Agreements to the Framework Partnership Agreement (FPA) for the Climate-Neutral and Smart Cities Mission Platform (HORIZON-MISS-2022-CIT-SGA, 2022)
Start date: 2023-06-01
End date: 2026-11-30
Duration (months): 42.0
Total project cost (EUR): 87239477.45
EU funding (EUR): 87239477.45
Participants: 29
Project status: SIGNED

This SGA provides comprehensive programming and support for the European Commission’s Mission of 100 Climate-neutral and Smart Cities by 2030. It builds on the NetZeroCities (NZC) project, coordinated by CKIC. Combined, these two projects set out actions as follows: (a) Create and operate a Cities Mission Platform as a ‘one-stop-shop’ to access the expertise, capabilities, services, and solutions necessary to achieve climate neutrality. This Platform will provide tailored and intensive support to cities participating in the Mission and will ensure open access to the knowledge and resources of the Platform. (b) Help all Mission Cities with the co-creation and use of Climate City Contracts (CCC) to enable an ambitious pursuit of the goal of climate neutrality by 2030. This SGA expressly seeks to ensure all Mission Cities are supported and builds directly on the initial scope of NZC. In addition, support will be offered to additional cities seeking to follow the Mission closely. (c) Assist Mission cities in the development of tailor-made investment plans, project preparation and finance for the cities participating in the Mission. (d) Deliver substantial resources to Mission cities for ongoing research and innovation activities critical to achieving climate neutrality by 2030. This support will be in the form of ‘pilot’ funding to test and demonstrate actions needed to deliver climate neutral outcomes. This pilot activity will work together with the Platform and CCC processes in the cities, operationalising emerging knowledge and insights about how cities can achieve the Mission objectives.

Keywords: cities mission,climate neutrality,investment planning,climate city contracts,large scale eu randi demonstrators
Modular metal-organic proton conductors for high-temperature water electrolyzers and fuel cells (MOPOWER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

The European Green Deal sets ambitious targets to reduce greenhouse gas emissions by 55% by 2030 and achieve net-zero emissions by 2050. Achieving these goals requires innovative solutions, with renewable hydrogen emerging as a key strategy. As a clean and versatile energy carrier, renewable hydrogen offers a promising pathway to decarbonize sectors such as transportation, industry, and energy storage, making it ideal for meeting the Green Deal's climate objectives. However, the production of renewable hydrogen is currently limited by the efficiency of electrolysis technologies, particularly those involving proton exchange membrane (PEM) electrolyzers. These systems, while effective, are constrained by low thermal stability and reduced efficiency at higher temperatures, which also hinders the broader adoption of hydrogen fuel cell electric vehicles (HFCEVs). To address these challenges, the MOPOWER project aims to develop advanced metal-organic glasses (MOGs) as a new class of proton conductors. Using a bottom-up strategy, MOPOWER seeks to design MOGs tailored for intermediate-temperature electrolysis (150–250°C) and high-temperature PEM fuel cells (100–180°C). These materials offer superior proton conductivity, thermal stability, and exceptional processability, allowing them to be easily shaped into defect-free, high-performance membranes. This modularity and ease of fabrication are critical for scaling up production and integrating MOGs into practical PEM systems. Through this innovative approach, MOPOWER aims to overcome the current limitations of renewable hydrogen production, supporting the transition to a sustainable, climate-neutral future. The MOPOWER bridges the candidate's strong background in conductive porous materials with the host group's extensive experience in microfabrication, making it a feasible undertaking.

Keywords: metal organic glasses,proton conductivity,high temperature electrolyzers,fuel cells,and renewable hydrogen
Targeting the Oncogenic hEag1 Ion Channel: Developing Venom Peptide-Based Pharmacological Tools (hEag1DrugDis)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 230184.72
EU funding (EUR): 230184.72
Participants: 1
Project status: SIGNED

The human ether à go-go 1 (hEag1) ion channel, also known as Kv10.1, is a voltage-gated potassium channel that is highly expressed in the brain but remains largely absent in other tissues under healthy conditions. However, during cancer development, hEag1 is significantly upregulated in various tumours, making it a potential biomarker and therapeutic target. Its role in cancer, particularly in breast cancer, is still not well understood, which makes exploring hEag1 a critical focus of my research. In this project, I aim to discover and develop the first series of selective hEag1 ligands that can be used as pharmacological probes and therapeutic leads to investigate the channel's function in breast cancer. Building on preliminary data, I will utilize the rich pharmacological diversity found in animal venoms to identify novel peptide ligands that target hEag1. Through structure-activity relationship (SAR) studies and advanced medicinal chemistry, I plan to enhance the potency and selectivity of both newly discovered and existing ligands. These optimized compounds will enable me to explore the functional role of hEag1 in breast cancer progression and assess its therapeutic potential. By integrating peptide chemistry, pharmacology, and preclinical methodologies, this research will pave the way for the creation of highly specific hEag1-targeting probes and drugs. The ultimate goal is to deepen our understanding of hEag1's role in breast cancer and unlock new avenues for targeted cancer therapy, especially for aggressive forms like triple-negative breast cancer.

Keywords: toxinology venom derived peptide voltage gated ion channel electrophysiology
Twinning for intensified enzymatic processes for production of prebiotic-containing functional food and bioactive cosmetics (TwinPrebioEnz)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,Netherlands,Spain
Call: Twinning Western Balkans Special (HORIZON-WIDERA-2021-ACCESS-02, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1466675.0
EU funding (EUR): 1466675.0
Participants: 4
Project status: SIGNED

The general objective of the project is to advance the research and innovation capacity of the Faculty of Technology and Metallurgy (FTM) in the area of prebiotics technology by collaboration with leading institutions with complementary expertise able to implement substantial improvement of the research staff profile, project management and administration skills. The consortium includes Maastricht University and Radboud university medical center contributing with the expertise in analysis of human microbiota, which provides determination of the activity of prospective gut and skin prebiotics, and Spanish National Research Council contributing with the expertise in protein engineering, which enables improvement of catalytic properties of enzymes applied in production of prebiotics. In addition to transferring knowledge within these two areas expertise, specific objectives are also to strengthen management capacities of the FTM, to unleash potential of young scientists and to form network of scientific community and potential industrial partners. Joint research is designed to result with joint scientific publication, which will increase research profile and attractiveness of the FTM and provide wider scientific impact by dissemination in accordance with open science concept. Additionally, wider economic, technological and societal impact will be facilitated through establishment of the Center of Scientific Excellence for Prebiotics and two innovative prebiotic technologies developed to technology readiness level 6. Still, motives behind formation of the consortium goes beyond goals of this project because long-term sustainable cooperation between four institutions is envisioned. All members of the consortium foresee increased demand for innovative prebiotic technologies, for which the consortium with such a high level of interdisciplinarity is needed.

Keywords: prebiotics,functional food,bioactive cosmetics,enzymatic processes
Harnessing the DNA Damage Response to improve plant tolerance to heat stress (HEATDDR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Germany,Belgium,Poland,Czechia,Hungary,Italy,United Kingdom,Switzerland,Netherlands
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 2356354.29
EU funding (EUR): 2254766.4
Participants: 17
Project status: SIGNED

In the context of climate change, Europe is facing new challenges that are threatening food security. There is thus an urgent need for the development of innovative strategies to improve plant tolerance to stress. Notably, recent years have already shown an unusual frequency of heat waves during the summer, a stress condition particularly threatening for yield as it cannot be mitigated in the field. Like many other kinds of stress, heat stress has a detrimental effect on growth due to reduction of the cell division activity in meristems. There is accumulating evidence that this growth reduction depends at least partly on the activation of the plant DNA Damage Response (DDR). The HeatDDR proposal aims at building on the acquired knowledge to decipher the links between the DDR and plant heat stress responses, and to fine-tune these cellular responses in order to allow plant survival without impairing growth. By bringing together groups with complementary expertise and private companies interested in this topic, HeatDDR will combine multiscale approaches including biochemistry, molecular biology, cell biology, genetics, computational biology and plant phenotyping to tackle this question and to train a new generation of scientists specializing in this emerging field. Trainees will work on both Arabidopsis and crops and will thus be aware of different plant models, and on specific challenges associated with breeding. Through the HeatDDR programme, ESRs will receive hands-on training on advanced laboratory techniques and develop transferable skills, thereby ensuring their successful integration on the job market either in the academic or in the non-academic sector, and setting the ground for the construction of European network of collaboration in this field.

Keywords: heat stress response,dna damage,crops
Multidimensional Representation: Enabling An Alternative Research Agenda on the Citizen-Politician Relationship (MULTIREP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1498727.0
EU funding (EUR): 1498727.0
Participants: 1
Project status: SIGNED

Political representation - the relationship between politicians and citizens - is at the core of democracy's legitimacy and functioning. Most empirical research in political science studies two aspects of representation: 1) whether politicians' substantive policy preferences match those of the citizenry, or 2) whether representatives are "like" their constituents in terms of descriptive characteristics (e.g. gender or race). However, recent research in political theory has highlighted additional dimensions of the citizen-politician relationship (e.g. whether citizens identify with politicians they have not voted for, how politicians relate to their party) and argued that citizens' own views of how they want to be represented should be the starting point for studying representation. Yet, these insight have barely affected how representation is studied in quantitative political science, suggesting that we may currently neglect important aspects of representation. MULTIREP aims to ascertain whether citizens care about further dimensions of representation and develop the methodological tools to study them, thereby fundamentally reshaping the scope and depth of empirical research in the field. First, it uses in-depth citizen interviews and survey-experimental techniques to determine how people think about representation and which dimensions are most important to them. Second, for the most important dimensions, it develops novel quantitative survey and text-analytical tools to measure citizens' preferences and politicians' behavior. Third, it advances and operationalizes normative standards to assess the quality of representation on these dimensions on the basis of empirical data. Thereby, MULTIREP will enable an alternative research agenda on the citizen-politician relationship that takes a broader perspective. Given citizens' declining trust in democratic politics, we cannot afford to maintain an incomplete picture of what it means for citizens to feel "represented".

Keywords: political representation political theory quantitative text models survey methods
Integrated emerging approaches for joint protection and restoration of Natural Lakes in the spirit of European life heritage support (ProCleanLakes) (ProCleanLakes)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Austria,Croatia,Czechia,Greece,Italy,Romania,Norway,Spain,France,Germany,Cyprus
Call: European natural lakes: demonstration of integrated approaches for protection and restoration of natural lake ecosystems and their biodiversity (HORIZON-MISS-2023-OCEAN-01, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 4207312.5
EU funding (EUR): 3968226.0
Participants: 18
Project status: SIGNED

ProCleanLakes targets to combat the combined impact of various disruptive factors that generate continuous pressure on the lake's ecosystem status and facilitate the accumulation of emerging, non-regulated, chemical contaminants and nutrient enrichment. The project will design and demonstrate the feasibility of integrated nature-based emerging approaches for joint protection and restoration of European Natural Lakes (ENL) and their biodiversity, considering scenarios which imply the presence of various pressures that affect the aquatic ecosystems' status. The holistic transdisciplinary approaches that are to be used in the project, based on the synergic effect of the economic-environment-social nexus, targets to support the improvement of ENL ecological and chemical status in association with major EU instruments, sustainable development goals and policies related to freshwater ecosystems. The project engages multiple sites affected by the presence of various pressures and stressors, that will be the subjects for the demonstration of integrated protection and restoration solutions efficiency. A replication roadmap powered by the necessity of assuring upscaling and universality of the optimal integrated solutions (IS) will be developed to prove the replicability. An IS support platform which merges a business accelerator with an adaptive artificial intelligence (AI) solution for empowering citizen science related to lakes protection and restoration will assure the collaboration between the municipalities and citizens and will offer capacity-building and encourage co-development and co-design towards natural lakes protection and restoration. Tools such as mobile decision support platforms, serious games for digital readiness, e-learning and augmented-based modules for reinforce-learning and multiple AI machine learning analytical frameworks will be developed to assure the synergic approach toward the maximization of integrated solutions impact and replicability.

Keywords: nature based solutions,climate change,water framework directive
Past Solar Storms: The links between solar storms and solar activity (PastSolarStorms)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 2498835.0
EU funding (EUR): 2498835.0
Participants: 1
Project status: SIGNED

Our Sun is a remarkably stable energy source which is crucial for life on Earth. However, we know that the Sun exhibits variations on a wide range of time scales. Occasionally, violent eruptions on the Sun’s surface, so-called solar storms, release energetic particles that can damage our modern society. Nowadays the Sun is constantly monitored and a wealth of information has been obtained about its variability from ground-based and satellite observations. However, our Sun exhibits variations that exceed the range measured during the space era as evidenced from sunspot observations over the past 400 years. Similarly, as demonstrated by historical observations and indirect proxy data, the Sun can produce solar storms orders of magnitudes larger than anything observed during the space era. Presently, we do not know the recurrence rate of large solar storms and how these are linked to solar activity. Mapping out the linkages may help to understand underlying processes and to predict the risks for future events. To achieve this we can take advantage of the “natural detector” of past solar activity – cosmogenic radionuclides in highly resolved and well-dated natural archives. I am proposing to develop this natural cosmic ray detector to increase its detection limit, resolution and reliability for assessing solar storms and solar variability in the past. This involves an assessment of the complete chain from solar energetic particles to cosmogenic radionuclide deposition for ground-truthing of the natural cosmic ray detector. Furthermore, novel ice core sampling and improved analytical methods will allow us to produce an unprecedented database for these studies. We will test hypotheses of the recurrence rate of solar storms and their relationship to solar activity. Our results will extend space weather research to millennial time scales and lead to a ground breaking new understanding of the temporal variability of our star.

Keywords: ice core research,cosmogenic radionuclides,solar activity,solar storms