Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bispecific bi-paratopic antibodies for the treatment of cancer (BiParatopic)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-04-01
End date: 2026-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the majority of patients do not respond to current treatments, such as PD-1/PD-L1blockade. In non-small cell lung cancer (NSCLC), over 70% of patients experience immune evasion mechanisms that prevent effective immune activation. One such mechanism involves the overexpression of glycans on tumor cells, which can modulate immune responses. In this project, we propose to develop novel bispecific bi-paratopic antibodies that simultaneously target two distinct epitopes of the target. This innovative approach is designed to provide a more comprehensive blockade of immune-suppressive functions by dual engagement of the receptor. Our bispecific antibodies will be engineered and optimized to target different epitopes, enhancing their ability to restore immune function. The project will involve the engineering, structural characterization, and functional validation of the bispecific antibodies, followed by preclinical efficacy studies in NSCLC models. By this approach, these antibodies have the potential to overcome the limitations of existing immunotherapies, offering a new therapeutic option for cancer patients who are resistant to current treatments. In addition to the scientific development, this ERC PoC project is designed to develop a robust commercialization strategy, with the potential for patent filings and engagement with pharmaceutical partners. Our vision is to bring these bispecific antibodies to the clinic, ultimately aiming to improve outcomes for patients with NSCLC and other cancers.
A metapredictive model of synthetic awareness for enabling tool invention (METATOOL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Netherlands,Germany,United Kingdom
Call: Awareness Inside (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 3298843.75
EU funding (EUR): 3298843.75
Participants: 8
Project status: SIGNED

Around 3.3 million years ago our ancestors made the first tool. They imagined a new utensil and then knapped a stone until it became an efficient tool for cutting. Tool creation was an outstanding technological milestone for humanity providing us with unprecedented control over our environment. This ability required cognitive capabilities, such as prediction, metacognition, abstraction, and creativity—all of which are associated in humans with awareness. Current artificial intelligence systems and robots largely lack these capabilities and cannot even monitor and evaluate the consequence of their actions let alone develop new tools to address environmental challenges. METATOOL aims to provide a computational model of synthetic awareness to enhance adaptation and achieve tool invention. This will enable a robot to monitor and self-evaluate its performance, ground and reuse this information for adapting to new circumstances, and finally unlock the possibility of creating new tools. Under the predictive account of awareness, and based on both neuroscientific and archeological evidence, we will: 1) develop a novel computational model of metacognition based on predictive processing (metaprediction) and 2) validate its utility in real robots in two use case scenarios: conditional sequential tasks and tool creation. METATOOL will provide a blueprint for the next generation of artificial systems and robots that can perform adaptive, and anticipative, control with and without tools (improved technology), self-evaluation (novel explainable AI), and invent new tools (disruptive innovation). Tool-making and tool-invention are outstanding technological milestones in human history. A similar breakthrough can now be envisioned in engineering. We already have algorithms to enable machines to use tools and now it is time to develop robots that create tools.

Keywords: awareness,predictive processing,metacognition,toolmaking,bayesian brain
Implementation of acoustic lens technology for Super-resolution Ultrasound Real-time microvascular Imaging using Erythrocytes - iSURElens (iSURELens)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The iSURELens Proof-of-Concept project will develop an ultrasound imaging system capable of visualizing the micro-vasculature of the entire human kidney in a clinical environment. Such ultrasound images are highly desired for providing early diagnosis of diseases such as cancer and diabetes using a non-invasive and cost-effective imaging modality. The proposed imaging system comprises a probe, lens and beamformer based on the methods developed in the SURE ERC synergy grant project for Super-resolution Ultrasound Real-time imaging using Erythrocytes (SURE) and is already compatible with a clinical scanner. Current high-resolution ultrasound probes for fast 3D imaging can only image a limited volume in front of the probe, which limits their clinical value. With the envisioned acoustic lens technology, the probe will have a field-of-view of 50 degree, which generates an imaging volume encompassing a full human kidney. In combination with the SURE method, such ultrasound system will enable to visualize, in just a few seconds, the microvascular structures down to 28 micrometers in the whole human organ. The developed system will be tested in a clinical setting to demonstrate its innovation potential. This will form the basis for either a potential spin-off company or a license agreement with a commercial ultrasound company.
(EN): FAKE NEWS AND CONSPIRACY THEORIES? LET’S EMPOWER (OURSELVES FOR) SCIENCE! (SI:)LAŽNE NOVICE IN TEORIJE ZAROTE? OPOLNOMOČIMO (SE ZA) ZNANOST! (oooZnanost)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Slovenia
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 327585.07
EU funding (EUR): 299586.53
Participants: 3
Project status: SIGNED

Our society faces increasing challenges, which the scientific community addresses by participating and contributing to various EU measures, like Horizon Europe and its missions, Open Science and many more. But their efforts are often undermined by fake news circulating and growing in social bubbles and echo chambers. ‘Fake news and conspiracy theories? Let's empower (ourselves for) Science!’ (Slovene Acronym: oooZnanost!, English Acronym: oooScience!) is the red line of the 11th edition of the European Researchers’ Night’s Night (ERN) project, which now includes Researchers at School activities under the coordination of the University of Maribor, which continues to engage the scientific community with various national and local media and primary and secondary schools. The project's main objective continues to raise awareness of the researchers' profession and reinforce their positive image, the benefits that scientists create for society, to stimulate curiosity and skills to detect fake news, misrepresentation and fabrication of scientific results/facts, and find reliable information through Open Science, and last but not least to inspire the young to embark the research profession. Those, as mentioned earlier, will be pursued by the researchers’ involvement in the Intensive Awareness campaign, numerous edutainment activities in festive spirit during the European Researches Nights 2024 and 2025 (Maribor, Koper, Izola), active involvement of our Researchers in Schools in many Slovenian cities and strengthening researchers' competencies and communication skills to interact with the non-research audience effectively, and followed by improved in-depth Impact Assessment studies.

Keywords: awareness raising,researchers,career,profession,science,infodemic,public,young
Secure 5G-Enabled Twin Transition for Europe's TIMBER Industry Sector (5G-TIMBER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Estonia,Ireland,Norway,Finland,Italy,Belgium,Sweden,Romania,France
Call: Data-driven Distributed Industrial Environments (Made in Europe Partnership) (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2025-10-31
Duration (months): 41.0
Total project cost (EUR): 9935115.83
EU funding (EUR): 7984101.0
Participants: 17
Project status: SIGNED

5G-TIMBER project aims to validate through robust evidence the latest 5G Industrial Private Network features and standards specifications for Wood Value Chain (WVC) under realistic conditions. In particular, to conduct advanced field trials of the more representative and innovative data-driven material, production and installation flows that implicate manufacturing across 4 prominent industries in the wood sector including, machinery and wood house elements manufacturing, construction and renovation towards green buildings, wood waste valorisation, and established telecom SME industries in a project remit that spans 3 representative European regions (Norway, Estonia, Finland). The project incentivises the opportunistic uptake of 5G in real-life business conditions. Specifically, 5G- TIMBER will target to increase wood-based materials recycling by 50%, increase manufacturing productivity by 15%, reach 99% of the work done in the factory (vs. 85% today), reduce on-site work by 10%, reduce product nonconformities by 10%, and increase the safety of workers in wooden houses production and onsite assembling. Validation of above overall targets through >100 interdisciplinary innovation driven technical, business and service-level KPIs for 09 diverse WVC usecases across 3 categories i.e., data driven sawmill woodworking machines; modular wood-house factory; construction and renovation with wooden elements, valorisation of composite waste. Usecases will be incrementally validated by 2 lab trials followed by 2 field trials in iterative cycle covering significant portions of end-to-end WVC. 5G-TIMBER also includes a comprehensive business case and exploitation strategy that incorporates novel approaches to materializing the value of data produced in industrial environments based upon 4 distinct business models. Our 16-partner consortium is driven by strong industrial and SME partners, renowned organisations the majority of which participate in FoF cPPP, 5G-PPP, GD projects.

Keywords: wood value chain,digital wood models,secure 5g 5g private network,digital twins,open standards,
Deterministic 6G-V2X Systems: A New Paradigm for Reliable V2X Networks (Deterministic6G-V2X)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

The Deterministic6G V2X project addresses the growing demands of autonomous driving technologies, which require substantial processing power as Connected and Automated Vehicles (CAVs) manage vast data streams and make real-time decisions. This involves processing extensive data from sensors like lidar, radar, and cameras, and integrating this information with data from other vehicles via V2X communication, enhanced by AI algorithms for effective decision-making. However, current vehicle processing capabilities are inadequate for the large data volumes generated by V2X applications. While 5G networks have integrated computing capabilities through Mobile Edge Computing (MEC), 6G networks aim to further embed AI and advanced networking across the Local-Edge-Cloud (LEC) continuum, enhancing processing and decision-making. The Deterministic6G V2X project envisions automated vehicles connected to 6G networks, enabling cooperative processing and task distribution across the network to maintain reliable communication, computing, and control within bounded latency. This requires a deterministic design of 6G networks, ensuring predictable and reliable interactions between vehicles and the network. Our holistic approach to deterministic 6G-V2X systems considers not just communication latency, but also computing and control latencies within the LEC continuum, optimizing processing unit selection based on computational power, bandwidth, and latency needs. This design aims to enhance the reliability, efficiency, and scalability of V2X systems and autonomous vehicles, advancing the seamless integration of next-generation networks.

Keywords: v2x,deterministic communications,local edge cloud continuum,connected and autonomous vehicles,intelligent transportation systems
Optimizing Capillary Flows in Twisted Fiber Structures (TWIST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 1999116.0
EU funding (EUR): 1999116.0
Participants: 1
Project status: SIGNED

The transport of drops on slender structures, such as threads and fibers, plays an essential role in engineering applications and is pivotal for the survival of many living creatures. The key to these processes lies in efficiently transporting drops and controlling their motion along the fiber. Drop flow control is enabled by manipulating the fiber’s surface properties, where today’s surface manufacturing methods hinge on advanced and costly techniques, including environmentally harmful chemicals. In the TWIST project, I will develop a new methodology for designing optimal drop transport on twisted fibers and nets. By mechanically twisting multiple fibers with different sizes, geometries, poro-elasticity, and physicochemical properties, I will create, through simple means and without the need for advanced microsystem technology, a hierarchical and grooved structure that can be tuned to control the flow of drops. The TWIST project aims to elucidate the fundamental fluid mechanics of drop capillary flows on these fibrous structures, even when exposed to wind and vibrations, and to provide new theoretical tools for describing the underlying fluid physics. Furthermore, the project will facilitate the development of pathways for utilizing sustainable materials, such as animal and plant-based materials, to generate twisted fiber structures with desired properties and utilize their hygroscopic responses. To showcase its potential use in applications, these fiber structures will be implemented in the fog net technology, which is used to capture atmospheric fog in arid regions. It is envisioned that TWIST will enable new research and engineering a pathways for a Do-It-Yourself solution to produce sustainable threads and nets, going beyond plastic based solutions. If successful, it offers a low-cost sustainable solution relying only on abundant materials found worldwide and can be developed without the need for advanced machining, and as such made by anyone, anywhere.

Keywords: capillary flows drops on fibers contact lines wetting
Multimodal Hypersprectal Imaging and Raman Spectroscopy for Intraoperative Assessment of Breast Tumor Resection Margins (Spectra- BREAST)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Netherlands,Spain
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 2990207.5
EU funding (EUR): 2990207.5
Participants: 6
Project status: SIGNED

The Spectra-BREAST project aims to revolutionize the assessment of tumor resection margins during breast conserving surgery (BCS). Currently, approximately 20% of breast cancer patients require a second operation due to incomplete removal of cancerous tissue. This results in increased costs for the healthcare system and significant negative effects on patients’ well-being. Nowadays, the standard margin assessment procedure is postoperative histopathological specimen analysis, which takes several days to complete. Although intraoperative histopathological analysis on frozen tissue is possible, it is less effective and cannot be implemented in all clinical centers. Alternative techniques have been suggested but have low diagnostic performance or take excessive time to assess the entire resected specimen. Spectra-BREAST aims to support surgeons with an intraoperative tool providing accurate and actionable feedback on the resection margin status over the whole specimen in less than 5 minutes. To this end, we will apply a radically new, high-risk multimodal approach combining two optical techniques, Hyperspectral Imaging (HSI) and fiber-optic Raman Spectroscopy (RS) with AI-based data-analysis. HSI and AI will be used for fast and sensitive detection of suspicious margins, which are subsequently analyzed by RS, and a second AI will make the final prediction on the RS spectra. The ambition is to identify tumors on and below the resection surface (up to a depth of 2 mm), with an unprecedented high sensitivity and specificity (over 95%) in real-time. Spectra-BREAST also has the potential for wider applications, going beyond breast cancer to include margin assessment for other cancers, robotic/laparoscopic surgery, and guided biopsy. Finally, Spectra-BREAST will offer an objective technology reducing variability between patients, and most importantly, will improve patient outcomes such as reduced hospital stays, complications, anxiety, and improved cosmetic outcomes.

Keywords: hyperspectral imaging,raman spectroscopy,tumor margins,breast cancer,deep learning model
A European Proactive Adaptive Clinical Trials Network within EU-Response (PROACT EU-Response)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Belgium,Ireland,Norway,United Kingdom,Austria,Netherlands,Switzerland,Spain,Italy
Call: Pandemic preparedness and response: Adaptive platform trials for pandemic preparedness (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 17474153.23
EU funding (EUR): 17042172.16
Participants: 26
Project status: SIGNED

Recent pandemics showed Europe how serious health threats can be to society. Proactive approaches are needed to ensure that medical countermeasures are available during pandemics. PROACT EU-Response’s overarching objective is to prepare Europe for future pandemics by strengthening upon existing networks of experts and civil society focused on clinical therapeutic platform trials within hospital inpatient settings across Europe. In case of an outbreak, this network will provide capacity to pivot rapidly to implement large, multi-country platform trials studying therapeutics and diagnostic-tool performance. Underpinned by strong community involvement and further strengthened by the inclusion of social and implementation scientists, PROACT EU-Response centres on six objectives: expand a solid network of clinical centres across Europe that will implement a clinical trial assessing a syndromic approach for respiratory viral infections; strengthen a laboratory network to identify pathogens and biomarkers of disease monitoring for routine surveillance; support a network of methodologists and trialists who will ensure the trials’ logistical and methodological aspects; initiate a network of professionals to work on preparedness tools to ensure a smooth pivot from inter-pandemic to the pandemic period in case of an outbreak; build a network of social science researchers who will provide nuanced understanding of the social contexts; and establish a community group to work on activities that will empower patients and citizens in Europe regarding their own health and educate them about science and health issues. By bringing together scientists, social science researchers, and civil society members, PROACT EU-Response will benefit the entire European population and beyond through decreased mortality and morbidity associated with emerging diseases, lower societal economic costs of morbidity, strengthened research and innovation expertise, human capacities, and know-how for combatting communicable diseases.

Keywords: clinical platform trial biological network innovative trial methodology civil society