Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Laser-as-a-Service Digital Platform with Dynamic Beam Shaping for Acceleration of Smart, Decentralised and Sustainable Factory of the Future (Lasers4MaaS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: United Kingdom,Germany,Netherlands,Austria,Israel,Italy,Finland,France
Call: Manufacturing as a Service: Technologies for customised, flexible, and decentralised production on demand (Made in Europe Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-12-01
End date: 2028-05-31
Duration (months): 42.0
Total project cost (EUR): 8042023.99
EU funding (EUR): 6687619.55
Participants: 12
Project status: SIGNED

Digital servitisation of manufacturing allows to produce on-demand customised products, with high quality, flexibility and short lead time. Although this is a win-to-win situation, there is a lack of methodologies. To reverse this trend, the project Lasers4MaaS will spearhead innovations in manufacturing technologies and digital platforms with associated services. The ultimate goal is to enable a 6-point strategy (reconfigure, connect, control, predict, improve, comply) to operationalise the smart, decentralised and sustainable factories of the future. Lasers4MaaS is set to deliver breakthroughs that merge manufacturing technologies with cutting-edge digital innovations. It marks significant scientific and technical advancements in several areas: the latest advances in dynamic beam shaping and modular production schemes to maximise flexibility and reconfigurability; harmonized protocols and distributed/centralised ledgers for data interoperability across factory boundaries; IIoT solutions for remote monitoring/predictive maintenance; real-time AI-based decision support for improved product quality; advanced physics-based digital twins; life cycle-based tools for environmental impact and costing assessment. The Lasers4MaaS digital platform, with its comprehensive range of services and breakthroughs, will be demonstrated in automotive, fusion, food packaging, aerospace and hydrogen sectors, which are considered strategic sectors for reaching the Green Deal objectives. This consortium comprising 4 academic partners, 8 industrial partners and an industry advisory board, ensures a seamless progression from TRL 4 to 6 with well-defined exploitation routes, while supporting standardisation initiatives, such as digital product passport, and facilitating training initiatives and knowledge transfer.

Keywords: laser welding dynamic beam shaping data interoperability real time ai based decision support digital twins sustainability circularity automotive,aerospace,fusion,food and hydrogen sectors
Radiometer based on nonlinear microwave to optical conversion in a resonator. (ATESCA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,New Zealand
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2028-02-29
Duration (months): 36.0
Total project cost (EUR): 280995.36
EU funding (EUR): 280995.36
Participants: 2
Project status: SIGNED

The ATESCA (Ambient Temperature Extremely Sensitive Radiometer for CubeSat Applications) project seeks to advance radiometer technology by achieving highly sensitive microwave detection for space-based applications, such as radio astronomy and Earth observation, without the need for cryogenic cooling of the detector. This project is particularly focused on improving the detection of microwave radiation from the ozone of earth’s atmosphere and from the cosmic microwave background (CMB). ATESCA radiometers utilize a nonlinear optical upconversion process to transfer weak microwave signals into the optical domain. This process is intrinsically noiseless, and it has been shown theoretically that a good signal to noise ratio can be achieved even when the whole setup is sitting at room temperature (opposed to direct detection of the microwave radiation). The nonlinear upconversion process is intrinsically weak. Hence the team plans to employ whispering gallery mode resonators, which support resonances in both optical and microwave domains to significantly improve conversion efficiency. It has been shown theoretically that with the planned implementation, a photon conversion efficiency from the microwave (> 100GHz) to the optical domain of 1% can be achieved. This will enable the proposed radiometer with high sensitivity but would also be interesting for future quantum technology. This is a planned collaboration between a group in Madrid, Spain (UC3M) and Dunedin, New Zealand (UoO). The researcher will demonstrate the proposed conversion efficiency and hence sensitivity on a benchtop experiment and, afterwards, will implement the system into two actual payloads for CubeSat missions to demonstrate the radiometer.

Keywords: optical resonator,whispering gallery mode resonator
Time-resolved sImulations of ultrafast phenoMena in quantum matErialS (TIMES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Italy,France,Germany,Belgium,United Kingdom
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2628158.4
EU funding (EUR): 2628158.4
Participants: 21
Project status: SIGNED

Emergent phenomena arising from excitation, correlation, and coherence of electrons, spin, photons and nuclei may open unexplored paths to exploit advanced quantum materials. Modelling and understanding ultrafast non-equilibrium dynamics is the key to quantum computing, to new paradigms for information storage and retrieval, to novel opto-electronic devices for efficient light emission and renewable energy production, and to efficient single-photon quantum emitters. The TIMES doctoral network will merge different areas of expertise in many-body and time-dependent electronic structure methods to define a new paradigm for the atomistic modelling of nonequilibrium processes in condensed matter. This is an area where the theoretical state-of-the-art is lacking in predictive power. On one hand modeling crucial dynamical processes such as the ones involving energy exchange between electronic and nuclear degrees of freedom out-of-equilibrium remains out of reach for current first-principles approaches. On the other hand, phenomenological and second-principles models lack the granularity required to quantitatively capture the evolution of complex materials. TIMES will develop first-principles theoretical and computational tools to tackle the coherent and correlated electron-nuclei dynamics stimulated by ultrafast laser pulses for the understanding of complex quantum states and emergent phenomena in a diverse range of functional materials like perovskites, 2D materials, Weyl semimetals, Dirac materials and topological insulators. For this purpose, TIMES will train a new generation of scientists capable of devising novel theoretical and computational frameworks to simulate nonequilibrium phenomena. TIMES will synergize theoretical and numerical developments with High Performance Computer Centers, SMEs, and big-data facilities across Europe. The network activities will benefit of synergistic collaborations with leading experimental groups in ultrafast spectroscopy.

Keywords: ultrafast optics,first principles methods,2d and quantum materials,electron phonon physics,exciton dynamics,high performance computing,quantum computing,defects in 2d materials
Novel Human Chaperone Mechanisms Counteracting Protein Misfolding and Aggregation in the Cell (CHARM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1999318.0
EU funding (EUR): 1999318.0
Participants: 1
Project status: SIGNED

MolecuMolecular chaperones are vital for maintaining proteostasis by protecting our cells from the deleterious effects of protein misfolding and aggregation. The diverse ~50-chaperone J-domain protein (JDP, Hsp40) family acts as cells’ first line of defense, binding and remodeling non-natively folded proteins and facilitating their transfer to downstream chaperones. Recent discoveries from our lab have shown that JDP function is far more complex than previously described - identifying both a novel mode of regulation by which DNAJB1 coordinates amyloid disaggregation, and a new mechanism by which class A JDPs recognize destabilized proteins. Based on these findings and the sheer diversity of human JDPs, we propose that these chaperones employ many additional, yet-to-be-discovered mechanisms to carry out their vital cellular roles. Obtaining a structural and functional understanding of these chaperones is further crucial, as mutations in JDPs have been linked to many pathologies, including myopathies, neurodegenerative diseases, and metabolic disorders. Here we aim to uncover these novel JDP functional mechanisms, determine their role in addressing diverse proteomic challenges, and characterize how their malfunction leads to disease. Study of JDPs has proven challenging due to the dynamic nature of these chaperones, their transient interactions with clients, and the instability of misfolded proteins. The advanced methyl-TROSY NMR techniques used in my lab are, however, ideally suited for such large and dynamic systems. Furthermore, we have developed new NMR and biophysical assays allowing the monitoring of chaperone interactions with misfolded and aggregation-prone substrates in real time. Using these approaches, this project will unveil the structures and functional mechanisms of the diverse human JDPs, introducing fundamental new concepts into the chaperone field and paving the way for therapeutic strategies targeting protein misfolding and aggregation diseases.

Keywords: molecular chaperones,nmr,protein misfolding,protein aggregation,methyl trosy,hsp70,j domain proteins jdps
Sustaining Public Administration in Modern Democracies (SUPA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Norway,Germany,Spain,Israel,Belgium,Sweden
Call: The role and functioning of public administrations in democratic systems (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-03-01
End date: 2028-02-29
Duration (months): 36.0
Total project cost (EUR): 2494217.5
EU funding (EUR): 2494117.5
Participants: 6
Project status: SIGNED

The “Sustaining Public Administration in Modern Democracies“ (SUPA) Consortium originates from the observation that public administrations in advanced democracies are increasingly overburdened. Administrative overburdening arises from a continuous increase in the number of rules that require implementation and the relative stagnation in administrative capacities. This discrepancy between the rules up for implementation and the administrative resources available results in suboptimal policy outcomes, low-quality public services, and inconsistent implementation practices. In view of this assessment, it is the central objective of SUPA to examine strategies for enhancing the capabilities of the public sector to cope with the escalating challenges of administrative overburdening. To this end, SUPA pursues two interrelated objectives: The first one is to examine how decision-making procedures and practices can be improved to limit the overall burdens placed on the administration. The second goal is to explore how administrative structures can be reformed to manage ongoing rule growth effectively. SUPA examines patterns of rule growth and the resulting administrative changes and challenges in six European States (Denmark, France, Germany, Norway, Spain and the Netherlands) and the European Union. Based on a combination of qualitative and quantitative methods, SUPA (1) evaluates the effectiveness of so-called "rule-offsetting" schemes; (2) investigates how legislators can embed legal design principles to prevent unintended rule growth cascades; (3) assesses how policy growth affects the underlying administrative structures; and (4) examines citizens' experience and operational challenges linked to different ways of distributing implementation burdens across public authorities. SUPA has formed collaboration agreements with multiple public authorities, ensuring that the Consortium's findings can be directly transferred to both policy-makers and administrators in the field.

Keywords: administrative overburdening rule growth policy implementation democratic governance environmental policy social policy
Federation of network optimisation services, simulation foresights, and data alchemy for adaptable, agile, secure, and resilient multimodal traffic management (FEDORA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Belgium,Austria,France,Greece,United Kingdom,Spain,Denmark,Cyprus,Hungary,Italy,Switzerland
Call: Optimising multimodal network and traffic management, harnessing data from infrastructures, mobility of passengers and freight transport (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 5066137.5
EU funding (EUR): 4999887.5
Participants: 18
Project status: SIGNED

Lack of orchestration, structured and standardized integration protocols and metadata descriptors, incorporation of real-world traffic complexities and nuances, underutilization of valuable resources, model uncertainties and integration of micro-mobility services and VRUs result in suboptimal performance in addressing complex issues related to the management of mobility services and infrastructure and a divergence from EU’s sustainable mobility targets. FEDORA aims to pave the way towards advanced traffic and network management through the development of a federated spaces platform offering a holistic framework of innovative solutions and services that enable precise and pro-acting sensing of supply and demand, facilitate optimal operation of transport services, and advances learning and evolution in complex environments. At the operational level, FEDORA offers a collaborative space of data that can realize advanced data alchemy processes using interconnected services and tools, a space of advanced traffic management optimisation services and a multi-modal simulation space to create and assess future mobility scenarios. The approach is validated in six thematic demonstrations in Vienna, the Basque country,Reggio Emilia, Nicosia, Budapest and Denmark, covering varying EU urban and rural contexts, infrastructure maturity levels, multimodal mobility services availability, organisation/operational structures and social conditions. Interaction with existing programmes on roadmapping and recommendations at national, EU and global level will be promoted, allowing a multiplication effect of project’s results.

Keywords: traffic management optimization interoperable simulation frameworks cross sectoral mobility data space dynamic governance models
Telemonitoring of home dialysis utilizing a smart biomimetic arteriovenous graft (TELEGRAFT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Innovation actions
Countries involved: Denmark,Sweden,Germany,Portugal,Lithuania,Spain,United Kingdom
Call: Smart medical devices and their surgical implantation for use in resource-constrained settings (HORIZON-HLTH-2021-TOOL-06, 2021)
Start date: 2022-09-01
End date: 2027-02-28
Duration (months): 54.0
Total project cost (EUR): 5298235.75
EU funding (EUR): 4352522.0
Participants: 13
Project status: SIGNED

Clinical need: 10% of the population worldwide is affected by chronic kidney disease (CKD) and millions die each year because they do not have access to treatment. Giving global shortage of kidney donors, the vast majority of patients rely on hemodialysis (HD). Over 2.6M people worldwide currently receive HD to stay alive, yet this number may only represent 10% of people needing treatment. Solution: Up to 70% of current arteriovenous grafts (AVG) fail in the first year after implantation. This is primarily due to thrombosis, luminal scar formation, and infection. In our ground-breaking new AVG, biomimicking zwitterions prevent thrombosis, drug delivery prevents scar formation and infection, and an ECM coating ensures fast tissue integration allowing early HD. Smart: TELEGRAFT comprises two diagnostic tools to monitor and prevent device complication. Pressure transmitters are used to monitor blood flow and optical sensors to detect inflammation and infections. The data is processed by AI machine learning models and displayed in an easy to understand dashboard for healthcare professionals. The data allows online telemonitoring and consultations by remote healthcare professionals. This makes home dialysis safe for patients, even in areas with poor infrastructure, where patients live far from HD clinics. Surgical implantation: The TELEGRAFT system will be demonstrated in an operational environment through a 2-stage randomized clinical trial enrolling 60 patients at 5 hospitals across Europe and through a home HD field study. Resource constrained setting: (1) In low and middle income countries, TELEGRAFT will substitute complicated and expensive kidney transplantation and allow simpler and cheap implantation of AVG for HD. (2) TELEGRAFT is the only solution with diagnostic tools allowing real-time online detection and remote monitoring of complications and device failure. This allows transition from HD at the hospital to the resource constrained home setting.

Keywords: artery venous arterio venous graft stenosis infection vessel vascular tissue surgery polymer homedialysis telemonitoring telediagnostic
PALUdiculture large-Scale DEMOnstrationS (PALUS DEMOS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Innovation actions
Countries involved: Ireland,United Kingdom,Netherlands,Austria,Germany
Call: Paludiculture: large-scale demonstrations (HORIZON-CL6-2024-CLIMATE-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 11056306.25
EU funding (EUR): 9999435.75
Participants: 26
Project status: SIGNED

PALUS DEMOS will establish 3 large scale paludiculture demonstration sites to provide insights in new agricultural business models, increased employment, and improved biodiversity and water quality in line with the objectives of the EU Green Deal. PALUS DEMOS will inspire entrepreneurs in agriculture, biobased manufacturing industry, communities, politicians, water and nature organisations and many others, that paludiculture will provide a new direction to preserve peat pastures, carbon stores and reduce GHG emissions. The proposed bottom-up approach (agriculture feeds science) is an opportunity that can improve social, economic and environmental sustainability, offering a future-proof model for agricultural entrepreneurs. Our demonstrators will act as lighthouses or beacons for local stakeholders and others from right across Europe & beyond. The focus of these demonstrators, supported by many of Europe’s leading experts, is to develop a range of best practices and land uses in strategic locations in three European countries ideally placed to spearhead the establishment of paludiculture practice and markets across Europe in a climate smart farming way. Beyond state of the art, we will establish co-created sustainable paludiculture practices at each of the three demonstrators. This will be fully supported by policy recommendations identifying enablers, barriers and policy gaps. We will work with stakeholders to develop (socio-)economic models using the quadruple helix innovation system, including government, industry, academia, and society. Our work will be supported by the development of long term business plans, it will include end users of the produced biomass and will be supported by Artificial Intelligence (AI) tools co-created with stakeholders leading us towards an evidence based policy approach to paludiculture innovation.

Keywords: paludiculture demonstrators,eu green deal,climate change mitagation,social innovation,water resources,developing markets,policy development,sustainable agriculture,dataandai for paludiculture