Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
OPTIMIZING CARE PATHWAYS AND QUALITY OF CARE FOR MODERATE-TO-SEVERE HYPERTENSION, DIABETES AND COMMON MENTAL HEALTH MULTIMORBIDITY IN MOZAMBIQUE (PEN-CONNECT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Netherlands,Mozambique,United Kingdom,Germany
Call: Implementation research for management of multiple long-term conditions in the context of non-communicable diseases (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2024-DISEASE-13, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 3999947.5
EU funding (EUR): 3999947.5
Participants: 4
Project status: SIGNED

Non-communicable diseases (NCDs) like hypertension, diabetes, and mental health conditions are a growing crisis in low- and middle-income countries (LMICs) such as Mozambique, straining healthcare systems and undermining national productivity. Individuals with multiple long-term conditions (MLTCs) face fragmented, poorly coordinated care, highlighting the urgent need for integrated solutions. PEN-CONNECT pioneers the integration of two WHO evidence-based strategies—WHO PEN (primary care) and PEN-Plus (district-level care)—into a unified framework to address these gaps. Already implemented in many countries WHO-PEN and PEN-Plus serve as a foundation for bridging primary and district healthcare levels to deliver timely, coordinated, patient-centred care for patients with MLTCs. The project develops integrated care pathways, leveraging digital health tools, and supported by implementation strategies co-created with stakeholders. PEN-CONNECT builds on the premise that strengthening the integration of PEN and PEN-Plus will be more effective than when addressed in isolation. By addressing critical knowledge gaps and contributing new theoretical frameworks, PEN-CONNECT advances the state-of-the-art for integrated MLTC care. PEN-CONNECT generates robust clinical, implementation, and economic evidence to inform global policy and practice, offering a scalable, adaptable model for LMICs to improve care and health outcomes. Its Roadmap including Implementation Toolkit offers actionable guidance, training materials, and decision-support tools for healthcare providers and policymakers, ensuring sustainability and scalability. The project aligns with SDG 3 and EU's commitment to global health equity. By strengthening healthcare delivery and reducing costs, PEN-CONNECT improves patient outcomes and quality of life for individuals with MLTCs while transforming NCD care in Mozambique and beyond. This collaborative initiative creates a benchmark for addressing NCD challenges in LMICs.

Keywords: patient centred care,multimorbidity,hypertension,diabetes,mental health,implementation science,social sciences,who pen,pen plus,mozambique,sub saharan africa
Edible Metal-Organic Frameworks for Food Fortification (EMOFFF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-08-31
Duration (months): 25.0
Total project cost (EUR): 268034.74
EU funding (EUR): 187624.32
Participants: 3
Project status: CLOSED

Insufficient intake of iron is one of the most common micronutrient deficiencies, with almost one-third of reproductive-aged women suffering from anaemia. Iron fortification of food products is an important route towards addressing this issue, but it is a notoriously difficult problem as product quality is often strongly compromised. While current strategies succeed in addressing some aspects of this challenge, they are often inadequate from a holistic perspective. Resolving these issues will help address societal challenges related to iron deficiencies, provide personalised nutrition, and support the growing adoption of plant-based diets. The objective of this research program is to explore the novel approach based on functional materials from metal-organic frameworks (MOFs) derived from iron (Fe) and edible plant-derived organic molecules, which can function as safe and bioaccessible by-design colloidal delivery systems. The approach will be based on selecting suitable organic ligands from the family of edible, plant-based polyphenols and acids, and use them in safe concentrations as Fe-based MOFs with pH triggered solubility (i.e. reversal back to the mineral and organic ligand) in the gastrointestinal tract. To achieve this goal, the following specific objectives will be met by developing new edible MOFs, both homogeneous and core-shell morphology, from Fe and plant-derived polyphenols and acids and evaluating their reactivity (e.g. oxidation, discoloration) and bioaccessibility in food products. If successful, this approach will enable the design of high-quality, mineral-enriched, plant-based food products. The proposed research program will lead to an increase in high-impact Research & Innovation output in the field of nutritious and functional food, specifically addressing the issue of iron deficiency. The expanded skill set of the fellow will improve his future employability and career prospects, both in industrial and academic research areas.
Carbon capture from syngas to Single Cell Protein (SCP) and use as fish feed ingredient (SynoProtein)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Norway,Denmark,Sweden,Germany,Netherlands
Call: Biogenic carbon capture and use (CCU) for circular bio-based products (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-09-01
End date: 2028-02-29
Duration (months): 54.0
Total project cost (EUR): 6117404.25
EU funding (EUR): 4995504.75
Participants: 13
Project status: SIGNED

Our SynoProtein project aims to develop, mature and demonstrate a novel carbon-negative process that enables high value creation from sawmill by-products through carbon capture and use (CCU). The consortium has developed an innovative process for the vertical integration of by-products from sawmill industry, i.e. feedstocks comprising only residues (no sawlogs), and conversion into fish feed ingredients, i.e. single cell protein (SCP), along with the production of biochar for animal feed. Thus, our process can provide novel, sustainable protein sources, as opposed to conventional energy- and climate-intensive soybean and resource-limited wild fish protein production routes to meet future demands. SynoProtein will demonstrate that 1.25 tons (t) of CO2-e can be captured from syngas via CCU for each dry-ton sawmill by-products processed. This clearly makes our SynoProtein innovation unique and is why it will introduce a green paradigm shift for the recycling and commercialisation of low-value by-products feedstocks into high-value bio-products. This project joins together a balanced consortium of 11 partners, covering the whole SynoProtein value chain, from industry, academia, and research institutes, which spread to 4 different European countries (Norway, Denmark, Sweden, and Germany), but with worldwide operation with their sister companies. Overall, we expect carbon capture of 200kt of CO2-e from syngas annually with our process by 2033, recovering 160kt/year of forest residues and producing 120kt/year of fish/animal feed for industry, valued at €175m. This also represents 260 jobs created in EU and reduced 120kt per year imported feed ingredient from other continents. Compared to fish feed production from soybeans, our SynoProtein is also expected to save carbon emission of 458kt CO2-e, land use of 147km2, and water use of 630,700m3 by 2033. It fits strongly with the mission of the CBE JU “advancing a competitive bioeconomy for a sustainable future”.

Keywords: single cell protein,scp,ccu,syngas,pyrolysis,syngas fermentation,forest residue,fish feed ingredient,biochar,animal feed,tar cracking,hydrogen oxidizing bacteria,methane oxidizing bacteria
Zagora Sustainable Hydrogen Region (ZAHYR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,Bulgaria,Latvia,Hungary
Call: Hydrogen Valleys (small-scale) (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 17322791.93
EU funding (EUR): 7999785.67
Participants: 16
Project status: SUSPENDED

Stara Zagora is a strategic logistic centre in Bulgaria and the Balkan Peninsula. It is also host to one of the biggest power production complexes in Europe (Maritsa East). This makes it the perfect location to showcase the versatility and potential of green hydrogen as means to improve air quality in the city, reduce CO2 emissions for energy production and mobility applications, and generate economic welfare. The demonstration of clean, safe, and sustainable hydrogen technology applications will improve public perception of hydrogen ecosystems, and kick start a hydrogen-based economy not only in the region but across the country. ZAHYR will install and demonstrate two electrolysers with a combined installed power of 5MW, to be run on green electricity produced in a new 20MW PV plant. The hydrogen produced will be used in various transport and energy applications. These include the installation of two Hydrogen Refuelling Stations to service a fleet of 10 city buses, 2 heavy transport trucks and 2 light-duty vehicles. A bi-fuel gas turbine will be installed in which blending limits between hydrogen and natural gas will be tested. A 1MW fuel cell at Stara Zagora will provide the municipality’s public night lighting, showcasing how this municipality can become net zero emission. Finally, a broad training and education program will be set up resulting in a master’s degree. An intense replicability activity will be carried out based on the organization of the Hydrogen Valley Development Group.

Keywords: green hydrogen electrolyser fuel cell hydrogen bus hydrogen truck p2p blending
Re-Imagining Informality: Theorizing Informal Entrepreneurship and Economic Change in Transition Era China (1970s–1980s) (INFORMALITY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-07-31
Duration (months): 26.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Although informality has long been considered a barrier to economic development, as more emerging market economies achieve growth even while remaining stubbornly informal, this assumption has become a subject of debate. Recent management scholarship has highlighted the supporting roles that informality plays in economies and the opportunities it provides for marginalized populations. Yet, because of the phenomenological and ahistorical nature of this work, the processes by which informality is produced, how it evolves over time, and how it influences macroeconomic change remain undertheorized. In this project, I attempt to address these lacunae through a novel historical approach and the analysis of unconventional sources collected from Chinese flea markets. Specifically, I apply the tools and frameworks of microhistory to analyze thousands of decommissioned case files of entrepreneurial actors who were prosecuted by Chinese state agencies in the 1970s and 1980s. Through this analysis I aim to: 1) Map the structure of informal networks of state and non-state actors and theorize the mechanisms by which they enabled the creative recombination of capital, labor, and knowledge; 2) Discover and categorize the collusive practices by which these actors pursued entrepreneurial opportunities, circumvented institutional constraints, and mitigated risk; 3) Reveal the entrepreneurial role of local administrators and theorize how their actions reshaped the context in which informal entrepreneurship operated. Through the fulfillment of these objectives, the project seeks to revise existing theories of informality by calling attention to how formal/informal boundaries were contextually and historically contingent and by revealing the bottom-up processes through which informal entrepreneurship drives change. The project also aims to generate societal and economic impact by developing applied business insights that will inform new entrepreneurial educational initiatives.

Keywords: institutional change informal entrepreneurship
TERRAVISION: Integrated Earth Observation based platform for novel services to enhance raw materials mining life cycle (TERRAVISION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Greece,Norway,Spain,Italy,Belgium,Germany
Call: Earth Observation platform, products and services for raw materials (IA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7728743.83
EU funding (EUR): 6688246.24
Participants: 16
Project status: SIGNED

TERRAVISION will establish and deploy an integrated platform to enhance the entire critical raw materials value chain towards implementing sustainable mining practices. TERRAVISION Earth Observation (EO) Mining Services Platform will be supported by 4 innovation pillars; (i) the Data Ecosystem for Large scale EO mining services will link and exploit various data from key sources (e.g. Copernicus satellite/ground radar/drone/in-situ sensing data) for monitoring the entire raw materials life cycle; (ii) the Analysis Ready Data and Raw material spectral library, will provide a novel framework for processing raw multisensory EO data to become Analysis Ready Data and to be combined semantically with in-situ data to enable the development of an open and standardised raw material spectral library to support the full mining life cycle of critical raw materials and the mapping of primary and secondary critical raw materials,(iii) the EO services for the mining industry will develop and deploy services critical to supply chain (e.g. mapping of critical raw materials, mineral exploration, extraction rates in opencast mines and stockpile volumes) but also enable a dynamic hazard mapping service for proactive management of risks to promote operational efficiency of mining sites. (iv) The Green & Resilience Accountability component will promote critical raw materials supply chain resilience and sustainability based on the quantification of environmental and socio-economic impact of mining activities for different mining phases (e.g. permission, operation, post-closure). The effectiveness of the TERRAVISION EO Mining Services Platform will be demonstrated at both EU (Greece, Spain) and beyond coupled by validation campaigns at 6 mining sites that will pave the way for rapid uptake of the proposed systemic innovations. Targeted dissemination, exploitation and replication activities will enhance a clear pathway for TERRAVISION towards significant EU-wide impact.

Keywords: remote sensing,mineral exploration,raw material extraction rate,ground deformations,earth observation,copernicus,mining services,eo mining platform
Neutrino experiments and data as a bridge to new physics (NuBridge)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States,Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2026-04-30
Duration (months): 41.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 3
Project status: SIGNED

The existence of new physics beyond the Standard Model of particles is firmly established by neutrino data and dark matter phenomenology, however the new physics nature and its energy scale remain elusive today. While significant effort has been put on the theoretical and experimental exploration of high-energy scenarios, the possibility that the new physics is relatively light and feebly coupled with the Standard Model is a valid option that received comparatively fewer attention. The coming years will provide a propitious and timely framework to test this possibility, given a wide array of experiments featuring extremely intense particle beams and massive precision detectors. We propose to exploit the full potential of this experimental program, using it to test low-scale new physics scenarios motivated by neutrino data, dark matter or experimental anomalies, focusing on the Fermilab accelerator neutrino program. We will complement this study with a model-independent search of new-physics effects in global neutrino data. Finally, we will provide the community with modern tools to ease the study and statistical inference of general new physics models in fixed-target experiments, including in the first release the full array of Fermilab accelerator experiments. The project will deliver relevant phenomenological results during its lifetime, looking for and constraining the hypothesis of a low-scale new physics sector, while its legacy will extend beyond this timeframe, by allowing a wider community to perform phenomenological studies in beam-dump experiments, thus increasing the number of independent searches for new physics. In the implementation, the Researcher will train on model building, data analysis and experiment simulation on site at Fermilab, collaborating with world level theoretical and experimental experts. He will then bring this expertise at University of Bologna, joining the newly established group on neutrino and astroparticle phenomenology.

Keywords: neutrinos,beyond the standard model of particle physics,dark sector,global fit of data,dark matter,software development,simulation software
Offshore renewable and clean desalination of sea water (ReWater)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Norway,Spain
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-08-01
End date: 2025-03-31
Duration (months): 32.0
Total project cost (EUR): 3601818.29
EU funding (EUR): 2500000.0
Participants: 2
Project status: CLOSED

Ocean Oasis (Norway) is a start-up focused on offering a clean alternative to current desalination solutions, making freshwater more available in coastal areas without large infrastructure investments. Our wave-powered desalination solution, Desalinator, will mitigate the impact of seawater desalination by reducing CO2 emissions and power consumption to zero. Our units can be installed between 1 and 5 km from shore without requiring any external power supply and safely disposing the brine without affecting the marine ecosystem. Each Desalinator is designed for a lifetime of 25 years, and our business model consists of long-term (>15 years) freshwater supply contracts with our customers, retaining the ownership of the buoys. Our goal is to reach 572 units operating by 2030 with an annual production of 150 million m3 in areas where water is scarce.

Keywords: desalination,blue economy,sea water,fresh water,water scarcity,offshore,zero emissions,energy harvest,reverse osmosis,wave energy,cleantech
Saving vision: expanding use of lentiviral gene therapy to fight blindness (EuroVision)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Sight is the most treasured of our senses, followed by hearing and balance. Moderate to severe vision loss affects more than 216 million people worldwide, with an estimated 36 million people suffering from blindness. Monogenic diseases caused by mutations in genes such as MYO7A are responsible for vision loss in over two million people. As current treatment options for genetic vision loss are limited or non-existent, there is a high clinical need for innovative approaches, such as gene therapy. Usher syndrome type 1B (USH1B) is caused by MYO7A mutations and patients suffer from profound deafness accompanied with loss of balance and vision. In my ERC-funded consolidator grant iHEAR and Proof-of-Concept grant MY(O)SENSES, we showed the first ground-breaking data for efficient gene transfer with lentiviral vectors into inner ear cell types and correction of hearing and balance defects caused by mutated MYO7A. The EuroVision PoC proposal aims to advance these valuable research results towards clinical application by completing pre-clinical development, securing IP rights and commercializing a formulated medicinal product to launch a first-in-human clinical LV gene therapy trial to treat USH1B patients. The EuroVision product will be the first and only single-vector treatment that addresses vision loss due to MYO7A mutations in USH1B patients, which has great potential to significantly improve quality of life for these patients as well as to benefit society through relief of costs associated with healthcare and lost productivity. Moreover, this ground-breaking therapy will lay the basis to address other monogenic eye diseases, in which large genes need to be transferred and for which there is an urgent medical need.