Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bio-based sustainable SURFactants TO foster GREEN industry (SurfToGreen)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Italy,Sweden,Finland,Belgium,Spain,Czechia,France,Germany,Bulgaria,Japan,China
Call: Development of scalable, safe bio-based surfactants, with an improved sustainability profile (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 9062801.0
EU funding (EUR): 7346987.5
Participants: 19
Project status: SIGNED

Formulations in industrial applications primarily rely on fossil-based surfactants/polymers significantly contributing to environmental pollution (CO2 increase, microplastics) and are scarcely sustainable. The EU Green Deal demands for new chemistries based on sustainable and natural compounds. Effective bio-based surfactants are poorly integrated in industry and in their infancy in research. SurfToGreen will fill this gap with a completely new surfactants platform covering diverse industrial applications to replace current surfactant benchmarks. SurfToGreen gathers a unique partnership of major industrial actors and excellence research centers, with the advanced knowledge on soft matter and industrial processes fundamental to achieve this challenging goal. Biomass derived building blocks will be obtained from EU territorial value chains, including forests and agriculture waste/side streams to diversify biomass origin, and used to synthesize novel biobased surfactants. The new products will cover anionic, nonionic, cationic, zwitterionic surfactant families, and biopolymers-oligomers from renewable sources with no impact on the food chain. The platform will be validated in three industrial demonstrators among the most fast-growing crucial sectors, i.e., home/personal care, textile, and agriculture. The compounds’ surface properties will be assessed against detergency, interfacial, and rheological behaviour. Polymers/oligomers, hydrotropes and surfactants will be used for encapsulation to protect and control the delivery of actives (perfumes, and compounds for plant protection). Digital technologies and safe-and-sustainable by design methodologies will assess the functionality, safety, and sustainability of the biobased formulations within a circular value chain framework. Finally, extensive exploitation and communication will be carried out to promote the SurfToGreen advancements as a pilot to drive a paradigm shift in EU and global industry.

Keywords: new sustainable surfactants platform,industrial side streams,renewable sources,home and personal care,textile ennoblement,actives encapsulation,safe and sustainable by design,co2 reduction
Glass, alchemy and medicine. Evidences of domestic practices in the capital of the Andalusi Caliphate (GALENE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: CLOSED

The study of material culture is one of the main tools for the past societies’ knowledge. Recently, new techniques, protocols and disciplines applied to traditional archaeological methodology have proved that glass played an important role in economic and social development through history. Regard to the Iberian Peninsula, works on archaeological glasses has focused on purely typological issues, above all from the Roman times, leaving aside other later historical periods. As part of our cultural heritage, the study of glass in al-Andalus can help to understand aspects and practices of Andalusian societies. For this reason, the project ‘Glass, alchemy and medicine. Evidences of domestic practices in the capital of the Andalusian Caliphate’ (GALENE) is proposed, which main objective is to establish the classification of glass for cosmetic and medicinal uses in domestic contexts of this period. This project proposes the study of an important set of glasses from Cordoba (Spain) by combining different skills and multidisciplinary approaches (traditional studies, experimental archaeology and the chemical analysis of materials) to determine for the first time the importance of glass in alchemy and medicine in Medieval times, the origin and manufacture of these vessels and objects, their evolution and whom used them, with especial attention to the female gender. GALENE will be conducted by Dr Velo at the Glass and Ceramics for the Arts (VICARTE) research unit of the Universidade Nova de Lisboa (Portugal), under the supervision of Prof Vilarigues. VICARTE is a research group of international relevance that combines different areas for the study of glass in antiquity and in the plastic arts. This centre has the facilities and technology necessary for the development of this project that will reinforce the protection of our cultural heritage and contribute to the integrity of the cultural diversity of today’s society, which is the result of our past and history.

Keywords: andalusi glass,islamic culture,ancient glass,islamic medicine,islamic alchemy
Holomorphic Partial Differential Relations (HPDR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Slovenia
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1476375.0
EU funding (EUR): 1476375.0
Participants: 2
Project status: SIGNED

The aim is to develop an emerging field of complex analysis and geometry focused on holomorphic partial differential relations (HPDR). Such a relation of order r is given by a subset of the manifold of r-jets of holomorphic maps between a pair of complex manifolds, and the main question is when does a formal solution lead to an honest analytic solution. This complex analogue of Gromov’s h-principle is highly important but poorly understood. The project will focus on the following problems. (A) Oka theory concerns the existence and approximation of holomorphic maps from Stein manifolds to complex manifolds, corresponding to HPDRs of order zero. The central notion of Oka theory is Oka manifold; this is a complex manifold such that the h-principle holds for maps from any Stein manifold into it. Recently developed techniques give a promise of major new developments on Oka manifolds and their applications to a variety of problems in complex geometry. (B) Open first order HPDRs. Oka-theoretic methods will be applied in problems concerning holomorphic immersions and locally biholomorphic maps. (C) First order HPDRs defined by analytic varieties in the jet bundle. Application of Oka-theoretic methods in holomorphic directed systems, with emphasis on complex contact manifolds and holomorphic Legendrian curves. (D) Applications of Oka theory to minimal surfaces. Development of hyperbolicity theory for minimal surfaces. The Calabi-Yau problem for minimal surfaces in general Riemannian manifolds. Study of superminimal surfaces in self-dual Einstein four-manifolds via the Penrose-Bryant correspondence. These closely interrelated topics embrace major open problems in three fields, with diverse applications.

Keywords: oka manifold,stein manifold,complex contact manifold,minimal surface
Active reduction of noise transmitted into and from enclosures through encapsulated structures (IN-NOVA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Poland,Spain,United Kingdom,Belgium,Germany,Italy
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2634711.43
EU funding (EUR): 2522160.0
Participants: 12
Project status: SIGNED

To better reduce exposure of people to noise and increase their acoustic comfort, innovative noise barriers should be developed. The overarching aim of IN-NOVA is to provide a top-level training for 10 Doctoral Candidates (DC) - MSCA Fellows plus 3 DCs funded by UK (supervised by UCL - 1 DC and UOS - 2DCs), in a wide variety of cutting-edge noise control technologies, developing a new generation of creative and entrepreneurial innovators. The DCs will benefit from a unique soft-skills training programme that will kick-start their careers as highly employable professionals. To reach these goals, IN-NOVA has pooled the interdisciplinary, complementary and multisectoral expertise of leading research universities and innovative global companies in the fields of acoustics, vibration, materials engineering, signal processing, and control sciences, represented by outstanding researchers and practitioners. All SRs will get strong intertwining academic and non-academic supervision to jointly develop novel, complete concepts for innovative barriers to reduce noise transmitted into and from enclosures through encapsulated structures (dual problems), thus creating a more pleasant and healthier local soundscape in workplaces and leisure areas as well as in car and aircraft cabins. They will use structural design, destructive interference of waves, holistic approaches to soundscape forming, metamaterials, and employ advanced combined active, novel passive and semi-active technologies. The IN-NOVA research, training and outreach activities will have an important and lasting impact on the DCs, members of the consortium, individual people, society, environment, international scientific community, industry, policy makers, and on the EU as a whole. It will propose first standards and labelling rules for active noise control systems. It will also make possible reduction of mineral resources and energy consumption due to reduced weight of the structures. The project is fully consistent with EU, WHO and UNESCO policy declared in numerous acts.

Keywords: active noise control,noise cancellation,noise barriers,soundscape,acoustic metamaterial
Continuous Digitalized Processes for Producing Biopharmaceuticals (CoDiBio)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Greece
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Biopharmaceuticals are essential for the medical treatment of diseases like immune deficiencies, cancer, and diabetes, and provide an indispensable component to the health care system worldwide, as showcased by mRNA vaccines in the recent pandemic. Despite this success, manufacturing is still based on traditional, outdated batch production technologies, and on process development procedures based on historical experience and empiricism leading to many inefficiencies, like very long values of time-to-market. There is an urgent need to introduce modern integrated, continuous, and fully digitalized production processes, to also cope with the upcoming cell and gene therapies and the emerging personalized medicine. I develop here revolutionary process development and operation methodologies to enable this. These are based on a Digital Twin, which includes the first continuous, integrated and fully digitalized plant for producing mRNA. The “engine” are innovative hybrid models for each unit of the plant, which are updated on real time through continuous learning techniques. These provide the predictive capabilities needed for monitoring and control, knowledge transfer, scenario analysis and experimental planning. I will develop a new generation of hybrid models and innovative machine learning algorithms and provide the experimental evaluation and validation of my methodologies. Other high precision continuous processes, like flow-chemistry for sustainable catalytic processes or microfluidics for the controlled synthesis of nanomaterials, will benefit from these results. I am a recognised pioneer in the scientific foundations of continuous operation in biopharma. This inspired me in developing this disruptive Digital-Twin-based methodology and cope with the associated high risk. With about 110 PhD students advised in my career and now active in Academia and Industry, I know how to inspire a new generation of scientists with the novel science emerging from this project.

Keywords: biopharmaceutical processes biochemical engineering
EX-DR TB: Elimination of Extensive Drug Resistance Through better Regimens for TB (EX-DR TB)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Germany,South Africa,Spain,United States,Sweden,Netherlands,Korea, Republic of,Italy,United Kingdom,Moldova, Republic of,Eswatini,Mozambique
Call: Tackling Antimicrobial Resistance (AMR) through R&D in novel and existing antimicrobials (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-10-01
End date: 2031-09-30
Duration (months): 72.0
Total project cost (EUR): 7098992.01
EU funding (EUR): 7098991.26
Participants: 17
Project status: SIGNED

In 2022, the World Health Organization (WHO) recommended bedaquiline (BDQ)-based, all-oral regimens including pretomanid (Pa), linezolid (L), and moxifloxacin (M) (BPaLM), lasting 6-9 months However, BDQ-resistance is rising dramatically and threatening these advancements. Mozambique has reported BDQ resistance in 28% of MDR-TB isolates in 2024, up from 3% in 2016 and at 10% in South Africa (Ndjeka N, personal communication). Spread of BDQ-R TB must be slowed by antibiotic stewardship through more rapid, accurate, and near-patient diagnostics, and optimized management; until new treatment options with drugs that have no pre-existing resistance or are able to overcome small shifts in MIC will be available. The proposed EX-DR TB project includes diagnostic capacity strengthening, adapting treatment recommendations, and a trial of two new regimens composed of new drugs. The EDCTP EX-DR TB project will: 1. Develop treatment recommendations by a Delphi process with stakeholders - to make use of targeted next generation sequencing (tNGS) that is being rolled out by most national TB programmes - this will yield short-term benefit for patients and NTPs; and will slow the spread of BDQ-resistant bacteria; 2. Rigorously evaluate two treatment regimens composed of new drugs, in a phase 3 clinical trial conducted to the highest regulatory standard – this will be the main focus of EX-DR TB. The trial objective will be to move a regimen towards regulatory approval by FDA and/or EMA, and WHO if supported by results. Thus, EX-DR will create the tools for containing the nascent epidemic of BDQ-R TB and make them available to healthcare providers and TB Programmes. EX-DR TB will be embedded in a larger coalition of funders and partners focused on implementing and evaluating diagnostics and performing the trial beyond of the EDCTP funded area.

Keywords: xdr tb,bedaquiline,resistance,tuberculosis,new chemical entitites
Intergenerational Transmission of Identity in sub-Saharan Africa (TransmId)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Belgium,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: SIGNED

In sub-Saharan Africa (SSA), high levels of ethnic diversity have often been considered in quantitative research as constraining social and economic development. Yet most of the research on ethnicity and development has given little thought to the complexity of ethnic identities, treating ethnic identity as a static affiliation to a single group. As such, it is not easy to reconcile findings from this literature with more recent empirical work that stress that multi-ethnicity is not a rare phenomenon in SSA and that ethnic identity identities may be less salient than national identities. In response, the TransmId project (Intergenerational Transmission of Identity in sub-Saharan Africa) proposes a novel understanding of ethnicity by focusing on the intergenerational transmission (IGT) of identity in SSA. By studying which identity traits (e.g. language use, religious practice) are passed down generations, we can gain a more nuanced understanding of ethnicity while considering it both as socially salient and dynamic. The project combines insights from the theoretical economic literature on parental investment in IGT with perspectives from political science and sociology on institutional factors and socialisation mechanisms. TransmId relies on economic modelling, statistical analyses, and first-hand data. The project’s workflow follows the sequence of intergenerational transmission over generations, from marriage decisions to investments in children’s identities. First, I will focus on understanding the drivers of intermarriages using data from the Democratic Republic of the Congo. Second, I will design a lab experiment in Kenya to assess parents’ preferences regarding their children’s identity (e.g. multi-ethnicity, ethnic and national identities). Third, building on case studies and on a cross-country longitudinal analysis, TransmId will provide a comparative perspective on the role of institutional contexts in shaping IGT decisions.

Keywords: marriage intergenerational transmission africa education nation building policies
Synthetic hEalthcare dAta goveRnanCe Hub (SEARCH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Ireland,Germany,Netherlands,Greece,Norway,Spain,Denmark,Sweden,Cyprus,Italy,Belgium,Switzerland,United Kingdom,Israel
Call: Maximising the potential of synthetic data generation in healthcare applications (HORIZON-JU-IHI-2023-05, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 13573062.5
EU funding (EUR): 7916214.3
Participants: 30
Project status: SIGNED

The objectives of SEARCH are truly ground-breaking, seeking to enable extensive data aggregation and analysis while safeguarding the integrity and privacy of original datasets through synthetically derived proxies. This initiative is designed to address biomedical challenges in Europe and offer translational solutions that will ultimately contribute to the advancement of personalised medicine. Unlike traditional data-sharing platforms that mainly focus on technical obstacles, SEARCH adopts an innovative approach by addressing legal, ownership, and subject privacy concerns. It specifically targets distributed institutional repositories that are hesitant to share multimodal clinical data, overcoming security concerns through a combination of clinical synthetic data proxies and a Federated Learning framework. Until synthetic data proxies gain wider acceptance, this combined strategy aimed at alleviating security concerns, facilitates the scalability required for AI analysis and promotes creative public-private data collaborations. SEARCH will offer advanced data federation capabilities, incorporating unique Synthetic Data Generation features to create various data types, including those not comprehensively addressed currently (e.g., wearable device data, image sequences, and genomic data). Through curated access to these novel digital tools, SEARCH will facilitate convenient access for the healthcare industry and research community to address bottlenecks and challenges in the development of novel tools for personalized prevention, diagnosis and treatment based on explainable AI. Moreover, SEARCH will provide agreed-upon gold standard synthetic datasets for evaluating the performance of biomedical AI solutions. SEARCH aims to consolidate European Innovation and Research endeavours by promoting public and private collaborations to unlock the potential for innovation in the digital healthcare sector.

Keywords: synthetic data,cardiovascular,gastrointestinal,gynaecological cancer,federated learning,data sharing,clinical decision support,stroke