Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engineering vasoactive probes for brain-wide imaging of molecular signaling (AVATar)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1492968.0
EU funding (EUR): 1492968.0
Participants: 2
Project status: SIGNED

Brain function depends on spatiotemporally defined brain-wide signaling via molecules such as neurotransmitters. No current technology can measure signaling molecules throughout the brain with sufficient spatial and temporal resolution in living mammals. This poses a major roadblock for understanding how molecular neuronal communication coordinates whole-brain function. Magnetic resonance imaging (MRI) currently provides the highest brain-wide resolution. Dynamic imaging of blood flow and oxygenation in the finely arborized vasculature, so-called functional MRI (fMRI), is the only method that can visualize whole-brain function in mammals and humans. However, MRI is inherently insensitive, which precludes it from accessing molecular signaling that occurs at (sub)micromolar concentrations and fMRI cannot resolve neurotransmitter signaling underlying measured hemodynamic signals. I previously designed protein-based vasoactive sensors, named AVATar, that directly cause hemodynamic signals in fMRI in response to target molecules at low nanomolar doses, without using radioactive or metallic components. They can be genetically encoded and also pave the way for noninvasive brain delivery through the vasculature, critical for translational applications in primates and humans. Here, I will combine my expertise in synthetic biology and in vivo molecular imaging to develop my proof-of-concept work into a robust preclinical neuroimaging method along three objectives: 1) Engineering AVATars that convert neurotransmitter signaling into hemodynamic signals. 2) Brain delivery via non-invasive routes. 3) Application for fMRI of brain-wide neurotransmitter signaling in rodents. My project will provide neurotransmitter-sensing AVATars to turn fMRI into molecular fMRI and bridge the long-standing gap between molecular nuclear imaging and functional hemodynamic imaging. AVATars will visualize how brain-wide molecular signaling dynamics shape healthy and pathological brain function.

Keywords: bioengineering,synthetic biology,molecular sensors,molecular imaging,signaling,mri
PROGNOSIS IMPROVEMENT OF UNPROVOKED VENOUS THROMBOEMBOLISM USING PERSONALIZED ANTICOAGULANT THERAPY (MORPHEUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: France,Spain,Sweden,Germany,Netherlands,Denmark,Poland,Switzerland
Call: Optimising effectiveness in patients of existing prescription drugs for major diseases (except cancer) with the use of biomarkers (HORIZON-HLTH-2022-TOOL-11, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 9958833.5
EU funding (EUR): 9958833.0
Participants: 20
Project status: SIGNED

Venous thromboembolism (VTE) is a frequent and life-threatening disease. In 50% of cases, VTE occurs in the absence of any major risk factors (unprovoked VTE). In these patients, when anticoagulation is stopped after 3 months of anticoagulation, more than 35% will develop recurrent VTE. Consequently, international guidelines recommend to treat these patients “indefinitely”. However, such practice exposes them to a substantial increase risk of bleeding. Nevertheless, after several years of anticoagulation in all patients with unprovoked VTE, the risk of anticoagulant-related bleeding is expected to exceed the risk of recurrent VTE after stopping treatment. In addition, extending anticoagulation indefinitely in all patients with unprovoked VTE exposes 65% of patients to an unjustified high risk of bleeding, who would never have experienced recurrent VTE after stopping treatment. In this setting, optimal duration and management of anticoagulation remains a pivotal and unresolved challenging issue which has the potential to markedly improve long-term prognosis of unprovoked VTE. Based on quantitative and qualitative approaches, MORPHEUS will for the first time integrate (i) clinical, laboratory and imaging biomarkers (personalized medicine) and (ii) socio-anthropological markers (patient-centred model) into sets of prediction rules for optimizing anticoagulant management integrated in a shared decision-making process. The ultimate goal of the European “MORPHEUS” project will be to develop and validate a time-dependent multi-component tool integrated in a shared decision-making process regarding anticoagulant treatment duration in patients with unprovoked VTE. The whole MORPHEUS program, leaded by a consortium of outstanding European researchers in the field of VTE, will constitute a major breakthrough compared with the present standard of care in patients with unprovoked VTE with major scientific, public health, economic, and societal impacts.

Keywords: venous thromboembolism,anticoagulant treatment,precision medicine,personnalized medicine,socio anthropology,translational,research biomarkers
Real-time, High-throughput, Coherent X-ray Microscopy: from Large-Scale Installations to Tabletop Device (HYPER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-01-01
End date: 2025-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Recent advances in Coherent X-ray Microscopy opened new exciting avenues for 2D/3D imaging, allowing to visualize deformations in batteries and solar cells during charge migration, magnetic topologies, catalysts pollution, transistors fabrication defects, neuron activity. These emerging applications are expected to offer significant growth opportunities to market players in the coming years, complementing the possibilities offered by optical and electron-based microscopy methods. However, the expansion of this technology is currently hindered by its availability at facility-scale installations, where implementations are expensive and limit accessibility to a highly-specialized community. In ULTRAIMAGE (851154), we tackled the challenge by scaling this technology to a tabletop device, while retaining flexibility and complementary facility-scale performances. Specifically, we prototyped a coherent XUV microscope which offers the following advantages: (i) femtosecond time- and Ångstrom-to-nanometer spatial resolution; (ii) exquisite material composition and height contrast, through amplitude and phase; (iii) self-diagnostic capabilities of aberrations and misalignments; (iv) quantitative, multimodal, non-destructive imaging. HYPER aims towards the next step of R&I, increasing robustness, throughput, speed, and availability to the public, while retaining cost-effectiveness. Key to this advancement is: (i) implementation of beamline-style, real-time, diagnostics of intensity, spectrum, wavefront of the illumination; (ii) use of code parallelization, deep-learning, and fast XUV detection technology. Accessibility to a broad range of stakeholders and end users, and the translation to market of the consolidated technology, will be deployed through a strategic network of academe and industry partners. HYPER will foster broad, unprecedented understanding of functionality at the nanoscale, vital to the design of next generation optoelectronics and biomedical devices.
Conductive oxide-based dispersions from non-critical raw materials for functional nanoinks (CONDINKS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Transparent conductive oxides (TCOs) inks combine high transparency in the visible and high electrical conductivity with the benefits of solution processing for printable electronics. The most promising TCO, Sn:In2O3 (ITO), is currently being replaced on the transparent conductive inks market due to supply risk of ITO. Alternatives range from silver flakes, to copper pastes, or graphene and other carbon based materials. However, the remarkable environmental stability, chemical tunability, and optoelectronic properties of TCOs remain unbeaten. Hence, it is time to invest into good alternative TCO inks from non-critical raw materials. In CONDINKS, we have identified some of the major issue, limiting the performance of TCO nanocrystals in conductive inks related to 1) their electronic structure and depletion layer formation and (2) dopant segregation. Segregated on the surface, dopants might remain inactive and, hence, do not contribute to the conductivity. Segregated in the core might result into large depletion layers. Both effects significantly influence thin film conductivity in particular on the nanoscale. The solution offered by CONDINKS is based on two objectives: 1. Making conductive inks from non-critical raw materials with properties competing with benchmark systems through nanoscale dopant engineering; 2. Upscaling of the produced materials, with first attempts towards reactors in aqueous-based flow synthesis processes. The breakthrough innovation of our product is immediately obvious: similar (or superior) properties to commercially available materials with lower cost and lower supply risk. CONDINKS has put together a team of researchers with industrial support to tackle the high-reaching goal to develop conductive inks based on non-critical raw materials with enhanced performance due to dopant engineering.
Dynamic Techno-Economical Scenario Simulation Model for Sustainable Waterborne Activities and Transport (NEEDS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Coordination and support actions
Partnership: ZEWT (co-programmed)
Countries involved: Netherlands,Norway,Greece,Germany,Belgium
Call: CSA identifying waterborne sustainable fuel deployment scenarios (ZEWT Partnership) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-05-01
End date: 2023-10-31
Duration (months): 18.0
Total project cost (EUR): 523437.5
EU funding (EUR): 523437.0
Participants: 7
Project status: CLOSED

NEw sustainablE fuel Deployment Scenarios for the European waterborne community: NEEDS Deployment of sustainable energy within an existing transport network is a challenge which requires an independent and transparent analysis and overview. To be successful, it implies a timely coordination of all stake holders, from energy production capacity, to storage & bunkering logistics in harbours and up to the end-users: the inland waterways and maritime transport, and waterborne activities. Much information about each stake holders, their characteristics in terms of technical readiness, emission level, actual transport capacity, costs, scalability and impact are available. Putting all parts of the puzzle together is the aim of the present study. We are ready to apply existing scenario simulation techniques, containing among others regional information on transport network and hindcast data of weather conditions (for regional energy production), to simulate different scenarios of sustainable fuel deployment. Forcing certain variables as input into the model in order to study its impact on other quantities, will help evaluating the viability of certain scenarios or identify bottlenecks and best tactics to overcome them. This dynamic techno-economic model will hopefully help the commission, the member states, the regional waterborne community and the harbours evaluating the most efficient pathways towards their energy transition, for local to regional scale. The amount of details brought into the parameters of the model will allow to run such simulation from micro to macro scale. The model will primarily focus on variables and parameters related to the waterborne community. However, it will not be closed and will able a possible future inclusion of other sources of energy needs, if made available from land-based activity and transport, or aviation.

Keywords: zero emission,maritime and inland waterways transport,sustainable energy,scenario simulation model
Europe’s Rail Flagship Project 6 - Delivering Innovative rail services to revitalise capillary lines and Regional rail services (FP6 - FutuRe)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Europe's Rail
Action type: Innovation actions
Partnership: EU-RAIL (JU-JTI)
Countries involved: France,Italy,Spain,Norway,Austria,Poland,Portugal,Germany,Sweden,Belgium,Czechia
Call: Regional rail services / Innovative rail services to revitalise capillary lines (HORIZON-ER-JU-2022-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 20467166.64
EU funding (EUR): 15450251.32
Participants: 52
Project status: SIGNED

Regional railway (lines with lower usage or secondary network) plays a crucial role not only in serving European regions, but also as feeders for passenger and freight traffic for the main/core network. Therefore, they have an essential function as an environmentally friendly mode of transport. In addition is as well essential their link to other public transport services (e.g. bus) and to first and last mile services, such as bikesharing, cycling, walking or driving to get from/to stations to remote locations. Unfortunately, many of these routes were abandoned in the past - mainly due to high costs. Therefore, these rail lines need to be revitalized or even renewed to make them economically, socially and environmentally sustainable and to meet current customer needs and challenges The overall objectives of the FutuRe project are to ensure the long-term viability of the regional railway by reducing the total cost of ownership (TCO), while ensuring high service quality and operational reliability. It also aims to increase customer satisfaction and to make rail an attractive and preferred mode of transport. Therefore, the main objectives of FutuRe are: lowering CAPEX system costs, increasing productivity by lowering OPEX (unit costs per train kilometre), and improving customer satisfaction. These goals are to be achieved through a concept tailored to regional railways but transferable across Europe, encompassing digitalisation, automation and the use of common and new technologies for signalling and track components, rolling stock and customer information. Cost drivers such as infrastructure and energy components, e.g. trackside train detection (axle counters, etc.) and level crossing control systems, will be replaced by less costly wireless and energy-autonomous components. In addition, a modular and standardised vehicle concept specifically tailored to the requirements of regional lines becomes needed, as well as a range of attractive services.

Keywords: regional railway,ccs and operations,rolling stock,railway infrastructure assets,railway services,cost efficient railway
METROFOOD-RI Early Phase Implementation (METROFOOD-EPI)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Italy,Belgium,Czechia,Germany,Spain,Greece,North Macedonia,Poland,Portugal,Romania,Slovenia,Türkiye,Switzerland
Call: Early phase implementation of ESFRI Projects which entered the ESFRI Roadmap in 2018 (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-01-01
End date: 2024-12-31
Duration (months): 12.0
Total project cost (EUR): 1523013.5
EU funding (EUR): 1499897.43
Participants: 13
Project status: CLOSED

METROFOOD-RI is a distributed research infrastructure (RI) that promotes scientific excellence in food quality and safety. It provides metrology services in food and nutrition across various highly interdisciplinary, interconnected fields along the food value chain, such as agrifood, sustainable development, food safety, quality, traceability and authenticity, environmental safety, and human health. In May 2022, it completed its preparatory phase upon the H2020 METROFOOD-PP project (GA871083). However, a few bottlenecks were identified in the final evaluation report; furthermore, the consortium prepared plans for the next short- and medium-term phases and the Board of Governmental representatives proposed several suggestions. METROFOOD-EPI was established with the overarching mission to build METROFOOD-RI as an infrastructure consolidated for its full implementation and to begin the operational phase, addressing any critical issues. Four specific objectives have been identified: support the establishment of the legal entity that will manage the RI, specify the technical implementation of the RI as service-oriented, consolidate its position in the landscape and secure long-term sustainability. METROFOOD-EPI will act on four layers, covering: ERIC set-up, including membership consolidation, governance establishment, securing funding, and distributed architecture; technical organisation and implementation of the RI for its operation, including a definition of user requirement specifications for the e-component and set-up of the core components, data management solutions, access, and services; consolidation of the RI’s positioning in the agrifood research & innovation landscape, including an update of the scientific strategy and contribution to the ERA, community building, and liaising with other complementary initiatives; long-term scientific & financial sustainability, including impact, risk management and user engagement.

Keywords: health and food,metrology in food and nutrition,eric setup,technical organisation,data management,e ri core components,services to users,scientific and financial sustainability,risk management
Supporting the transition towards circular economy in European cities and regions: Development of a replicable model for local circular economy projects (InvestCEC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Coordination and support actions
Countries involved: Israel,Spain,Belgium,Denmark,Austria
Call: Circular Cities and Regions Initiative’s project development assistance (CCRI-PDA) (HORIZON-CL6-2022-CIRCBIO-01, 2022)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 1961575.0
EU funding (EUR): 1961575.0
Participants: 7
Project status: SIGNED

With 75% of the EU’s citizens living in urban areas, the potential of circular economy for European cities is clear. However, one of the main issues hindering a widespread deployment is that compared to industrialized economies, circular economy business cases are often perceived as risky by investors, often because the business models are poorly described or understood. InvestCEC will develop a replicable model for the implementation of circular economy projects in cities and regions across Europe, while taking into account all relevant stakeholders. Specifically, the model will address the city and region’s needs, support entrepreneurs in making their circular economy solution investment ready, and include the investment program set up and management. The model viability will be then demonstrated in the city of Klagenfurt, Austria as a test case. InvestCEC will also develop a platform for the stakeholders involved in a circular economy project to communicate, exchange information, as well as monitor the project and its progress. A tailored replication plan including replication materials and replication activities will be established in order to encourage the replication of the model in other local and regional settings across Europe. Alongside the model’s development and demonstration, the project will carry out prospective activities and implement measures to support the transition towards circular economy, including policy-related work, information exchange events, marketplace of circular economy solutions, and additional resources, tools and guidelines for the use of all stakeholders.

Keywords: waste management,rereplication,circular cities,circular regions,ccri,imapct investments,circular economy investments,replicated model,circular economy policy,