Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Commercialising cardiac autonomic modulation to treat Atrial Fibrillation (Neuron-AFib)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2022-07-31
Duration (months): 33.0
Total project cost (EUR): 3358205.0
EU funding (EUR): 2348941.0
Participants: 1
Project status: CLOSED

Atrial Fibrillation (AFib) is a debilitating and life-threatening condition with a high and increasing prevalence worldwide. However current treatments have low success rates and have significant risks and complications. Moreover, the most widely used treatment – cardiac ablation - still has limited adoption with the majority of patients hesitant to be treated knowing the potential for poor outcomes and complications. In addition, current treatments have even lower success rates and higher complications in women. AtriAN Medical is bringing a revolutionary treatment to market that is the first to specifically target the origin of the signal that causes AFib, thus eliminating the arrhythmia and disease progression. In addition to increased success rates, the AtriAN technology will reduce the risk of complications and the procedure will be done in a fraction of the time needed for current treatments; approximately 2 hours compared to 6-8 hours. The treatment will work equally well in women and men. AtriAN conservatively estimates that it will have turnovers of €85M per annum within one year of regulatory approvals. AtriAN has a senior management team in place with significant medical device industry experience in technology development, manufacturing and scale up from start-up to multinational size. AtriAN needs to perform a clinical trial in order to gain CE-marking to allow sales in Europe. AtriAN is planning for CE approvals by 2022 and FDA approval by 2026. The proposed Neuron AFib project will first finalise the device testing and validation needed in order to meet regulatory requirements and will then perform the clinical trial, with equal female and male enrolment, in order to demonstrate safety and efficacy of the treatment. AtriAN has already raised €3.8 million of funds needed to close out research activities but needs another €2.4 million to execute on the testing, validation and clinical trial needed to reach CE approval and commercial launch.

Keywords: atrial fibrillation,ablation,arrhythmia
Trapping and Removal of X-ray Contrast Medium agents from water resource and stream Sediments- New Concepts in Trapping, Recycling and Management (REMEDI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Italy,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2025-08-31
Duration (months): 56.0
Total project cost (EUR): 1348543.44
EU funding (EUR): 1348543.44
Participants: 3
Project status: SIGNED

REMEDI trains future professionals and scientists in the area of competitive use of water resources within an industry centered environment, targeting the problem of scarcity of water resources due to contamination by pharmaceuticals. Enhanced loading of water resources with pharmaceuticals is a key challenge in meeting the objectives of the EU Water Framework Directive. Iodinated X-ray contrast medium agents (CMA) are one type of the pharmaceuticals being used for the imaging of soft tissues which are typically administered in elevated doses for each imaging operation and excreted mainly nonmetabolized. The CMA are persistent during conventional biological wastewater treatments and therefore, CMA have been detected at elevated concentrations in the effluents of waste water treatment plants, surface waters, groundwater, and even in drinking water. Tauw GmbH is an environmental company which recognizes that design of strategies for treatment of water resources requires solid knowledge leading to new methods and approaches to trap pharmaceutical components in water treatment systems and in the sediments of lakes and rivers. Tauw GmbH does not have in-house resources to undertake the body of research required to set and develop. It has stimulated the REMEDI EID action, jointly with Politecnico di Milano and University of Warwick, to address these issues. Trapping of CMA involves the application of iron(Fe)- containing by-products from drinking water treatment. REMEDI aspires the ideas of a circular economy and aims at recovering the retained X-ray Contrast Media agents in water treatment systems, rivers and lakes. Novel technologies will be developed to convert CMA-loaded Fe-minerals into marketable products whose suitability will be evaluated. 5 ESR projects address these challenges with a level of interaction and synergy among academic and non-academic players leading to forming a cadre of scientists with skills apt to unravel complex environmental scenarios.

Keywords: pharmaceutical related contamination
Supporting the progress of renewable energies for heating and cooling in the EU on a local level (progRESsHEAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Germany,Austria,Romania,France,Czechia,Denmark,Portugal
Call: Market uptake of existing and emerging renewable electricity, heating and cooling technologies (H2020-LCE-2014-3, 2014)
Start date: 2015-03-01
End date: 2017-10-31
Duration (months): 32.0
Total project cost (EUR): 1728305.6
EU funding (EUR): 1728305.0
Participants: 11
Project status: CLOSED

The RED, the EED and the EPBD (recast) require member states to develop ambitious policies for sustainable heating and cooling. The objective of this project is to assist policy makers at the local, regional, national and EU-level in developing and implementing integrated, effective and efficient policy strategies achieving a fast and strong penetration of RES and EE in heating and cooling. This will include the analysis of cross-sectoral effects between RES and EE measures in industry, buildings and DHC as well as the link to the electricity system. The core part of the proposal is the communication and capacity building process with policy makers, administrative staff and other stakeholders at the local, regional and national level including the set up of policy group meetings, expert consultations, experience sharing and capacity building workshops as well as webinars. The process will focus on 6 target countries and regions. Together with the authorities heating and cooling strategies will be developed through a profound analysis of their specific situation including barriers & drivers and a model based assessment of policy intervention in scenarios up to 2050. progRESsHEAT will assist national policy makers in implementing the policies published in the national heating and cooling plans in an effective and efficient way by the means of a model-based quantitative impact assessment of local, regional and national policies up to 2050. Data, scenarios and recommendations will be provided for the target countries. Dissemination activities will transfer results to other countries and the EU-level. Policy makers and other stakeholders will be strongly involved in the process, learn from the experience in other regions and gain deep understanding of the impact of policy instruments and their specific design. This will provide the ground for favourable, stable conditions for increasing the efficiency and the penetration of renewable heating and cooling in Europe.

Keywords: energy efficiency,buildings,industry,district heating,policies,local heating and cooling strategies,national heating and cooling plans,capacity building
boosting Performance with an Innovation associate with TeCHnical and business ExperRtise on short food supply chains (PITCHER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Serbia
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-29
End date: 2018-09-28
Duration (months): 12.0
Total project cost (EUR): 77075.0
EU funding (EUR): 77075.0
Participants: 1
Project status: CLOSED

Health benefits have become a central guiding point for food purchasing decisions, favouring agrifood producers that can credibly market these benefits. Short food supply chains (SFCs) empower local producers who have a large competitive advantage in this new agrifood market. However, current retail is well below market potential. InoSens has integrated providers of mature ICTs, supply chain analysis consultants, and various end-user groups for an innovative SFC-facilitating concept, which directly addresses end-user needs not satisfied by existing business models. In baseball, the pitcher sets-up up the play and leads the entire team. InoSens seeks an experienced researcher with SFC expertise and advanced modelling skills that the company does not possess and are not available on the local labour market. The Innovation Associate will allow for several challenges the company is presently facing to be effectively addressed: system complexity, lack of key structural parameters and insufficient data. The Innovation Associate will develop a dynamic and precise methodology (including a modelling tool) to empower informed decisions for future innovation projects, and identify the best market for demo launch of the concept. The Innovation Associate will be positioned as a senior analyst working full time on the project. S/he will report directly to the CEO of the company, who will be personally responsible to provide ad hoc support for his work and development from company’s staff and capacities. InoSens embraces a startup company culture, we will be highly reactive to identify and react to the professional development needs of the Innovative Associate and smoothen her/his transfer into the private sector. The company strategy favours long-term investments with people, therefore the optimal scenario for the company is to employ the Innovation Associate beyond the lifetime of PITCHER.

Keywords: short food supply chains,business modeling,supply chain analysis
PROtocols for information Models librariEs Tested on HEritage of Upper Kama Sites (PROMETHEUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Italy,Spain,Italy,Italy,Poland,Russian Federation
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 391000.0
EU funding (EUR): 391000.0
Participants: 10
Project status: SIGNED

PROMETHEUS objective is to implement an interdisciplinary action for the documentation and structuring of information about architectural heritage, boosting the training of researchers on the constructive and historical value of Cultural Heritage Routes. The research will develop innovative methodologies of digitisation of architecture with the integration of multidisciplinary data and Information Models, leading to specialised figures able to operate on heritage built assets. The definition of a “charta”, for the replicability of action, will be pursued with a practical action on the monuments present in three cultural heritage routes as pilot case of study. The network of researchers from different sectors involved in the action favours/supports the cultural and thematic widening necessary to develop and show the skills that the market requires. The Italian expertise in digital survey of architectural heritage, the Spanish knowledge on building technology and census archives related to architecture, together with the historical and territorial planning knowledge provided by the Polish partner, will allow researchers to deal with professional companies that operate in the intervention fields of restoration projects and BIM Management. The research project will develop an information/cognitive 3D system, multidisciplinary and implementable, that represents the preparatory step for to the management, maintenance and valorisation of Cultural Heritage Routes over European committees and administrations. The system, in order to be widely applicable, will be Low cost and easy to replicate, and it will optimize an innovative channel of cooperation between researcher and professionals though the use of BIM Collaborative Protocols. Participants will exchange skills and knowledge that will allow them to progress in new methods of documentation and conservation, to strengthen collaborative research and to widen their career perspectives in European Heritage Preservation.

Keywords: information modeling,digital survey,digital databases,conservation and restoration,collaborative bim management,architectural heritage management,cultural heritage routes
Environmental public goods From Farming through Effective Contract Targeting (EFFECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Estonia,Italy,Germany,Germany,Germany,Spain,Spain,Romania,Hungary,Romania,Finland,Hungary,Netherlands,Netherlands,United Kingdom,United Kingdom,Denmark,Denmark
Call: Contracts for effective and lasting delivery of agri-environmental public goods (H2020-RUR-2018-2, 2018)
Start date: 2019-05-01
End date: 2023-10-31
Duration (months): 54.0
Total project cost (EUR): 4999365.0
EU funding (EUR): 4999365.0
Participants: 23
Project status: SIGNED

The European agricultural land areas provide important and valuable goods in the form of food, fibre and biomass for the world. They are also crucial for the provision of a number of environmental and climate goods and services. EU member states have implemented agri-environmental schemes, investment grants for environmental technologies, and private actors have established environmental certification and labeling schemes targeting these services. However, many initiatives are arguably not cost-effective in boosting environmental and climate service provision, may be skewed in terms of distributional impacts, increase risks to farmers, or involve excessive transaction costs. EFFECT will develop and pilot a theoretically well-founded and empirically well-adapted package of new contractual frameworks. This will enable farmers to reconcile agricultural production with enhanced delivery of environmental and climate public goods and services to the benefit of society at large. EFFECT pursues this through a transdisciplinary effort involving a review of past successes and failures; and development and test of new forms of contracts. We combine agricultural and environmental science knowledge with theoretical and empirical insights from law, political science and economics. We further combine efforts from researchers and multiple practice partners and stakeholders to ensure that lessons learned from previous initiatives and our testing of emerging contract frameworks are validated on the ground. Our ambition, which is based in the solid experience in the consortium, is to facilitate that our co-developed agri-environmental contract arrangements are being put to actual use towards the end of the project. Furthermore, to ensure durable impact of the project, EFFECT initiates a cross European innovation process, supports capacity building among decision making bodies and develops a policy evaluation framework.

Keywords: payments for agro ecosystem services,institutional analysis,spatial environmental targeting,policy implementation,collaborative arrangements,field experiments,agri environmental schmes
Variable Compression Ratio System for the reduction of fuel consumption and CO2 emissions in motor vehicles (GOMECSYS VCR system)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Netherlands
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Increasingly stringent emission and fuel economy standards have been pushing old combustion engines into an accelerated evolution phase. In this context, OEMs in the industry have shifted their R&D efforts towards more thermally efficient, less polluting and down-sized engines, thus viewing the production of low emission and fuel consumption vehicles. The concept of VCR engines (i.e. the compression ratio (CR) of the internal combustion engine can be modified under dynamic driving conditions and performance needs) has been considered as an essential future technology to meet these targets. However limitations associated with their effect in engine’s architecture, their impact on the reduction of CO2 emissions and additional productions costs have hindered their widespread commercial application. Our ground-breaking VCR system will be the first able to address the burning needs of the industry. Gomecsys VCR system is a highly innovative system differentiated from alternatives due to its engineering simplicity able to significantly enhance the performance of conventional combustion engines achieving a staggering 5-10% reduction on fuel consumption and CO2 emissions. Our core aim is to commercialize the 6th generation of our VCR system in 2020 and its commercial viability will be based on our ability to define business opportunities in target markets and attract key partners and customer OEMs for our project. Moreover, we are convinced that our project will provide “resource efficient transport that respects the environment” which is considered a critical aspect to meet “Smart, Green and Integrated Transport” societal challenge addressed by Horizon 2020 programme. Finally, through the completion of Gomecsys VCR system project we expect to reach €15 million revenues five years after its commercialization. Phase 2 will require a €2 million investment, which will present a Cumulative Return of Investment of 4.99 in 2024.

Keywords: variable compression ratio,fuel efficiency,reduced emissions
Bright nanoparticle probes for amplified fluorescence in situ hybridization in cancer diagnostics (AmpliFISH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Rapidly expanding field of cancer diagnostics generates strong demand for new biosensing tools. In particular, it concerns probes for fluorescence in situ hybridization (FISH), that enables detection of DNA and RNA cancer biomarkers directly in diseased cells. Although FISH technique has already been accepted for cancer diagnostics in clinics, its applications are still limited because the method is slow, expensive and requires complicated amplification protocols to obtain sufficient fluorescence signal. Here, we propose a solution based on ultrabright DNA-functionalized dye-loaded fluorescent polymeric nanoparticles recently developed within the ERC grant BrightSens and protected by two patent applications. We aim to develop ultrabright FISH probes (nanoprobes) for cancer research and clinical diagnostics. These nanoprobes will feature single-molecule DNA/RNA sensitivity, low cost, fast and direct one step cell staining protocol, and compatibility with clinical samples and single-cell assays. The amplification of FISH performance will be ensured by our dye-loaded polymeric nanoparticles of 7-20 nm size that are ~1000 fold brighter than single organic dyes. The project is composed of five tasks: (1) Synthesis and optimization of FISH nanoprobes; (2) validation of FISH nanoprobes in cancer cell lines; (3) development of multiplexing assays for detection at least 9 biomarkers; (4) their validation in clinically relevant samples; and, finally, (5) commercialization of FISH nanoprobes. The developed probes will constitute highly competitive products that can greatly improve performance of FISH assays in clinics and research laboratories and thus impact human health. Therefore, they will be directly proposed for commercialization by licensing to existing companies and/or through creation of a startup.

Keywords: fluorescent nanoparticles,polymeric nanoparticles,nucleic acids,fluorescence in situ hybridization,fluorescent probes,detection of cancer biomarkers
EDA tools for Secure and Reliable High Level Synthesis Implementations (SecuReHLS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2024-02-14
Duration (months): 24.0
Total project cost (EUR): 165085.44
EU funding (EUR): 165085.44
Participants: 1
Project status: SIGNED

System on Chip (SoC) and Internet of Things (IoT) hardware accelerators are increasingly used in secure and critical applications, such as medical and automotive. For this reason, they need to have high levels of security and reliability at the same time. Hardware attacks are a serious threat for the security of hardware accelerators. Among them, Fault Attacks and Side Channel Attacks can breach even protected devices. Furthermore, injection of errors due to harsh environments may even lead to catastrophic failures of such accelerators. These threats are usually not concurrently addressed since their corresponding protections are not always compatible to each other. In a context, where designers use High Level Synthesis (HLS) flows to increase the productivity of designing hardware accelerators they must also ensure that security and reliability protections are taken into account by the HLS tools. In order to enable HLS flows to be the flow of choice for secure and reliable devices, we propose to provide to SoC and IoT designers, Electronic Design Automation (EDA) tools, capable to evaluate, improve and automate the insertion of protections during an HLS flow. Initially we will study the effects of HLS flows on the synthesis of manually protected high level descriptions. Afterwards, we will address concurrently security and reliability by automating the integration of compatible, countermeasures and mitigation techniques, inside the HLS flow, so as to automatically obtain secure and reliable RTL descriptions. Such tools and methodologies will help to minimize the corresponding overheads for protecting against each threat, while at the same time they will maintain the productivity of the HLS flow at high levels during the design of secure and reliable hardware accelerators.