Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering transcriptional regulation of NF-kB target genes using integrative omics approaches (RegulatioNFkB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

NF-kB is a family of transcription factors that regulate expression of genes that are involved in various cellular processes such as apoptosis, proliferation and differentiation. The NF-kB pathway is implicated in the initiation and progression of cancer and cancer cell drug resistance. Unfortunately, global NF-kB inhibition is harmful to the immune system; therefore, inhibition of a subset of NF-kB target genes that are linked to malignant transformation would be more appropriate. Different NF-kB target genes display distinct transcription activation kinetics, indicating that the molecular mechanisms driving expression of NF-kB target genes are strikingly diverse. Thus, it is highly interesting to study the factors that are involved in transcriptional activation of individual NF-kB responsive genes, both from a fundamental and clinical perspective. Here, we will develop two innovative strategies based on CRISPR/Cas9 based genome targeting combined with mass spectrometry-based technology to isolate single NF-kB target gene promoters upon NF-kB pathway activation and identify their constituents. We will also apply a complementary approach, ATAC-sequencing, to identify transcription factors that are involved in activation of NF-kB responsive genes. Moreover, we will study the underlying mechanisms and characterize the function of proteins that interact with NF-kB responsive promoters. Finally, the described mechanisms discovered in cancer cell lines will be verified and validated in small intestinal organoids, a non-transformed cell model for homeostasis in the intestinal epithelium. This ambitious and multidisciplinary project will greatly benefit from my expert knowledge regarding the NF-kB pathway combined with the expertise of the host laboratory in mass spectrometry and genomics. The project is expected to have a major impact in the research area of gene expression regulation in general and molecular cancer research focusing on the NF-kB pathway in particular.

Keywords: nf kb,tnf alpha,crispr,cas9
Favorable Conditions of the Spread of the Cult of Asclepius across the Transportation Network of the Roman Mediterranean: A Quantitative Evaluation (AscNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-15
End date: 2022-08-14
Duration (months): 24.0
Total project cost (EUR): 202158.72
EU funding (EUR): 202158.72
Participants: 1
Project status: CLOSED

The overall aim of the action is to clearly demonstrate that the application of the interdisciplinary theoretical and methodological portfolio of rising Digital Humanities to the study of ancient history is a promising path towards generating new knowledge about the past. I intend to push forward this notion by realizing a research project focusing on the innovative application of quantitative methods to analyze the potentially favorable conditions involved in the spatial dissemination of the cult of the Greek god of medicine Asclepius across the Roman Empire. The proposed research project aims to address the problem in the academic discussion that, so far, this topic has been explored mainly by established historiographical methods which are limited when dealing with the complex interplay among different variables involved in the spreading dynamics. The action will take place at the Department of Archaeology, History, Cultural Studies and Religion at the University in Bergen (UiB). The unique combination of my skills consisting of traditional training in the study of history and expertise in quantitative methods such as geospatial and mathematical modeling, network science and quantitative textual analysis will create a collaborative synergy with the interdisciplinary research efforts at the Department of Archaeology, History, Cultural Studies and Religion at UiB, i.e. efforts which are often lacking in other, more traditional discipline-based, departments. My supervisor will be Prof. Eivind Heldaas Seland, who is internationally recognized specialist on ancient history and shares with me the perspective on the importance of promoting the interdisciplinary science of history. The fellowship at UiB will allow me to fully engage in international research with high impact and enable me to shape the conceptualization of the future research directions and interdisciplinary collaborations in the related fields such as archaeology, study of religions, or historiography.

Keywords: cult of asclepius,ancient mediterranean,roman empire,spreading dynamics,quantitative approaches
Pizza Vending Machine with Innovative oven and refrigerated storage technology for improved performance and operations (MARGHERITA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our company, Cierreci Srl, specializes in designing and manufacturing advanced vending machine solutions, incorporating the most innovative technologies to offer a variety of vending machine solutions. One of our core strategic areas of focus has been in the area of pizza vending machines. Pizza vending machines entered the market over 10 years ago in response to market demand for more hot food vending machine products. However, while existing technology can prepare a tasty pizza in few minutes, the viability of pizza vending machines has been limited because machine designs have so far not been aligned to buyers' critical selection criteria. Through a combination of innovative product designs and component optimizations, we have developed a solution that matches this market demand. The principle innovations behind ou​r new pizza vending machine, known as MARGHERITA, reduce the overall size and weight of the machine as well as lowering production costs through lean manufacturing techniques. We achieve a 30% reduction in the depth of the machine through component modularization and a significant energy efficiency (+90%) thanks to our control algorithms that optimize the heating and cooling processes. Our close contact and relationship with vending machine distributors indicates that these are the changes they have been waiting for over the past 10 years. Our new Margherita machine will create €12 million in revenues by 2023, with an estimated 1,000 separate units operating globally. Our innovation benefits a vast value chain of stakeholders, ranging from vending machine operators and distributors to pizza manufacturers to delivery and logistics companies. Our new machine will enable scalability of this novel technology, enabling end users to enjoy a fresh, hot pizza in a variety of locations and settings (e.g. hotels, hospitals, airports, car parks) at any time of day.

Keywords: pizza vending machine,refrigeration,cooking,customer service,quality,infrared lamps,storage,energy efficiency
Improving resource efficiency through a protective film for hose reel irrigation (PROTECTOR)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hose reel irrigation systems are a type of sprinkler irrigation which is best used on irregular-shaped and difficult-to-reach areas. Although it is widely used, it presents some problems related to the high degree of friction between the hose carrying the water, and the ground. This fact implies larger labor force to move the hose, therefore provoking an inefficient use of resources (water and fuel); thus increasing fuel consumption and GHG emissions. This becomes particularly difficult at the time of rainy or muddy grounds by getting the hose stuck on the soil with no possibility to move and with the eventual broken of the hose or even the machine drive system. Moreover, the abrasion produced by the constant friction, deteriorates the hose, reducing its useful life. Irriland has over 24 years of experience in automatic hose reel irrigators, being one of the world leaders in the sector. In 2013, and based on the client’s feedback, Irriland started developing PROTECTOR, an absolutely novel, automated and easy to use accessory, based on a non-stick and water repellent protective film system placed between the ground and the hose. It allows to reduce hose friction (90% less) and protects hose from abrasion (doubling its life), transforming intensive irrigation by reducing operational costs (12% fuel savings), time (less irrigation cycles), and energy (10% less carbon emissions). Up to the date, several prototypes have been tested in different types of crops, reaching a TRL 6. Before entering the market, we need to optimize the final prototype, test it and validate it for a successful commercialisation. PROTECTOR was presented in the past November at Bolonia Machinery for Agriculture Fair with a big success, showing a clear market’s demand. End users will clearly benefit by using PROTECTOR, as they will achieve consistent savings in the operating costs, while doubling the useful life of the hose. Proving this market demand, we enclose 19 support letters of stakeholder

Keywords: resource efficiency,fuel savings,water savings,hose reel irrigation,protector film,sprinkler irrigation,irrigation accessory,hose friction,water efficiency,irrigation efficiency
Centre of Excellence of Forest-based Industry (LignoSilva)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Framework Partnership Agreement
Countries involved: Finland,Slovakia,Slovakia
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-04-28
End date: 2020-04-27
Duration (months): 60.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 3
Project status: CLOSED

The general objectives of the project is to create the Centre of excellence (LignoSilva) in the field of a forestry, wood-processing and a pulp-paper complex involving two major organizations, the National Forest Centre in Zvolen and Pulp and Paper Research Institute in Bratislava in cooperation with the European Forest Institute as a leading research organisations from high performance countries of the EU. LignoSilva will help to strategically transform Forest-based sector of the region towards the innovation growth based on the knowledge economy (in terms of RIS 3 SK vision) and the implementation of the principles of Green Economy. LignoSilva will represent the Centre of excellence that integrates research, development and innovation potential of a Forest-based industry that rationally links the chain of wood production, processing and utilisation. Project covers 4 interlinked priority areas: 1. Forest resources and sustainable wood production 2. Biomass and bioenergy 3. Paper-pulp technologies 4. Recycling and cascading system of wood and wood products use The intention of the project partners is to establish an autonomous entity by grouping a number of existing facilities into one cluster. CSA and FPA will be directed so that the newly established CE can benefit from massive past investments whilst bringing more dynamics into the forest based industry in Slovakia The CE will benefit from European Forest Institute and its network participation. EFI with its member is in a unique position to provide collective science-based insights at European and regional level to support informed policy making. Concerning LignoSilva EFI's Research function aims to (i) Conduct and promote interdisciplinary and cross-sector research of Forest-based industry and (ii) Support the coordination, strengthening and networking of forest research capacities aiming to overcome the fragmentation and low performance of FBI in Slovakia.

Keywords: forest resources,wood processing,pulp and paper industry,recycle and cascade system,knowledge transfer,training centre,smes facilitation
Thorium nuclear clocks for fundamental tests of physics (ThoriumNuclearClock)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Austria,Germany,Germany,Germany,United States
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-02-01
End date: 2026-01-31
Duration (months): 72.0
Total project cost (EUR): 13789990.0
EU funding (EUR): 13789990.0
Participants: 6
Project status: SIGNED

Th-229 has an exceptionally low-energy excited nuclear isomer state with an excitation energy of only a few electron volts, making it accessible to laser manipulation. With a predicted relative radiative linewidth of 1e-19, constructing a Thorium nuclear clock becomes possible that could rival todays most advanced optical atomic clocks. The few-eV transition emerges from a fortunate near-degeneracy of the two lowest nuclear energy levels. However, the Coulomb and strong-force contributions to these level energies differ on the MeV level. This makes the Th-229 nuclear level structure uniquely sensitive to variations of fundamental constants and ultralight dark matter. Very recently, the applicants have proven the long-sought existence of the low-energy isomer, determined the lifetime in different electronic environments, quantified the nuclear moments and charge radius based on the hyperfine splitting, and constrained the isomer energy. However, knowledge on the electronic and nuclear properties is still insufficient to exploit the Th-229 system for fundamental tests. This project aims to close this gap and realize three prototype nuclear Thorium clocks using complementary approaches in trapped ions and solids. We will develop customized VUV laser systems and perform precision spectroscopy of the Th-229 nuclear transition. Comparing these clocks among each other and with state-of-the-art optical clocks will allow us to benchmark the new frequency standard before ultimately applying it to test fundamental physics. This project requires a unique combination of experimental and theoretical expertise in atomic and nuclear physics, high precision metrology and fundamental symmetries. Furthermore, special infrastructure is required for (distributed) clock comparison, precision spectroscopy as well as processing of Th-229. The synergy team is composed to optimally respond to these challenges while being rooted in established and successful collaborations.

Keywords: atomic clocks and frequency standards,fundamental constants,dark matter search
Novel Light Emitters based on Nanostructures of III-Nitrides and Lead Halide Perovskite Nanocrystals (PEROGAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 145941.12
EU funding (EUR): 145941.12
Participants: 1
Project status: CLOSED

The proposal aims to produce novel light emitters by merging two promising semiconductor families, III-Nitrides and lead halide perovskite nanocrystals (LHP NCs) into novel nanostructured architectures. III-Nitrides are established emitters with widespread use in the lighting industry and high-density optical disks and with great promises for power electronic applications. On the other hand, the field of LHP NC photonics is at its infancy but breakthroughs have already been accomplished with demonstrations of optically-pumped lasers and light emitting diodes (LEDs). Research on the two material families has thus far proceeded independently. Yet new architectures with improved performance and functionality may emerge from their integration into hybrid devices that can exploit the favourable properties of each, namely the superior electrical properties and established technology of the nitrides with the ease of solution-processability, visible spectral tunability and high emission quantum yields (QY) of the LHP NCs. The proposed project will be investigating the potential flow of energy from the donor material (III-nitrides) to the acceptor (LHP NC), via radiative pumping but also via efficient non-radiative Förster energy transfer (FRET,) under optical and electrical excitation. Additionally is aiming to demonstrate hybrid electrically excited nanostructure devices, allowing the two materials to exist with nanoscale proximity. Moreover, the project is targeting to the fabrication of electrical-excited of a hybrid microcavity-based heterostructures, via an elaborate design of two back to back microcavities. The outcome of this project is expected to particularly benefit the scientific semiconductor area and industry fro the development of efficient high colour rendering index (CRI) LEDs for solid state lighting and display applications.The methodology for a demonstration of novel light emitters is highlighted in work packages (WPs) 3 to 5.

Keywords: iii nitrides,lead halide perovskite nanocrystals lhp ncs,nanostructures,hybrid,non rative fret,hybrid microcavity laser
The Effects of wages on patient safety outcomes (HONEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-12-01
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

One relevant cost category in the healthcare system are wages. The hospital setting in Switzerland, where wages can differ widely, is attractive because it enables an examination of the impact of wages on patient safety. We would expect that once wages differ within hospitals, it will cause differences in recruitment and retention, especially of well-trained workers, as satisfactory wage is a known significant factor in job-seeking behaviour and is important in keeping hospital workers in their current positions. Lacking well-trained workers in turn should lead to worse service quality and thus to worse patient safety. Current research has shown that hospitals with well-trained nurse staffing and work environments have better nurse and patient outcomes. However, many researchers fail to account for wage effects, the neglect of which may confound findings. Objectives: To describe physician and nurse wages in Swiss hospitals and to identify their main drivers (aim 1). To assess the association between physician and nurse wage and patient safety (aim 2). To conduct a cost-effectiveness analysis and a budget impact analysis of hospitals’ investments in nurses’ and physicians’ wages. (aim 3). Methodology: I will access 2 datasets from The Swiss Federal Statistical Office: the hospital statistics (4 subsets on the hospital level) and the medical statistics (inpatient episodes in the hospital on individual level). To test my hypothesis (aim 1, 2), I will use regression analyses with the wage per full-time equivalent as dependent variable. I will adjust the results for employers’ characteristics on the hospital level and individual patient characteristics as possible confounding variables. As the dataset is large (>1.2 million cases/year), I will use also Generalized Additive Models in order to adjust for clustering. Besides regression analysis, I will perform also Bayesian analysis in order to explore uncertainty of the results estimate. All analyses will be conducted in R

Keywords: health workforce,healthcare quality,wages drivers,hospital employment,patient safety,healthcare expenditures,well trained nurses and physicians
Codes for Design of Sustainable Structures (CoDe-S)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: SIGNED

Given the tremendous challenges our society is facing, i.e. in regard to the expected changes in our environment due to climate change and the increasing pressure on our natural resources, the international research community is in demand to find solutions that provide the foundation for our sustainable development. Here, the built environment is of obvious importance as it not only facilitates societal activity but also has a major share on the worldwide turnover of economic and environmental resources. To date the built environment is developed and maintained by broadly following structural design standards, which did evolve continuously over time and contain safety concepts that support daily structural engineering decision making based on simple calculus. The major objective that has been followed in their development, was the provision of sufficient safety, and the observed relative low failure rates do proof success in this regard. However, as conceived, structural design codes do not allow for the optimal allocation of the limited financial and environmental resources into the structural performance. In this context, the proposed project will develop methodologies to calibrate the safety concept of existing design standards, such that their broad implementation will lead to a significant increase of resource efficiency with simultaneous conservation of the present average safety level. Environmental, economic and societal aspects will be explicitly considered and the potential benefits will be exemplified on the building stocks of two European countries. Presented and disseminated by means of user-friendly tools and demonstrators in a form that is not only accessible to expert groups, but also to other stakeholders involved in standardization procedures, the results of the project are expected to have a substantial impact on future structural design procedures, contributing to sustainable societal development.

Keywords: standardisation,safety,structural reliability,risk based decision making,structural engineering,decision analysis