Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Using Embodied Cognition to Create the Next Generations of Body-based User Interfaces (BODY-UI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1853158.0
EU funding (EUR): 1853158.0
Participants: 1
Project status: CLOSED

Recent advances in user interfaces (UIs) allow users to interact with computers using only their body, so-called body-based UIs. Instead of moving a mouse or tapping a touch surface, people can use whole-body movements to navigate in games, gesture in mid-air to interact with large displays, or scratch their forearm to control a mobile phone. Body-based UIs are attractive because they free users from having to hold or touch a device and because they allow always-on, eyes-free interaction. Currently, however, research on body-based UIs proceeds in an ad hoc fashion and when body-based UIs are compared to device-based alternatives, they perform poorly. This is likely because little is known about the body as a user interface and because it is unclear whether theory and design principles from human-computer interaction (HCI) can be applied to body-based UIs. While body-based UIs may well be the next interaction paradigm for HCI, results so far are mixed. This project aims at establishing the scientific foundation for the next generations of body-based UIs. The main novelty in my approach is to use results and methods from research on embodied cognition. Embodied cognition suggest that thinking (including reasoning, memory, and emotion) is shaped by our bodies, and conversely, that our bodies reflect thinking. We use embodied cognition to study how body-based UIs affect users, and to increase our understanding of similarities and differences to device-based input. From those studies we develop new body-based UIs, both for input (e.g., gestures in mid-air) and output (e.g., stimulating users’ muscles to move their fingers), and evaluate users’ experience of interacting through their bodies. We also show how models, evaluation criteria, and design principles in HCI need to be adapted for embodied cognition and body-based UIs. If successful, the project will show how to create body-based UIs that are usable and orders of magnitude better than current UIs.

Keywords: user interfaces,embodied cognition,mid air interaction,gesture based user interfaces,embodied interaction
High Performance Computing in Life Sciences, Engineering And Physics (HPC-LEAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Ireland,Italy,Italy,Italy,Germany,Cyprus,Switzerland,Greece,Netherlands,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EJD) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 3667663.72
EU funding (EUR): 3667663.72
Participants: 17
Project status: CLOSED

Progress in computers and algorithms in the last years has made numerical simulation and modelling a key research methodology in both academia and industry, which in turn drives exascale computing in order to maintain excellence in research and innovation. A disruptive evolution in computer technologies is required for attaining exascale performances in the coming years bringing challenges that urgently need to be addressed across science and engineering fields. Therefore new interdisciplinary strategies are required in order to educate the next generation of scientists to address such challenges enabling them to be at the forefront of their respective research fields. Instead of the traditional domain-specific training, integrated approaches are needed that can be best implemented by collaborative networks of universities, research institutes and industrial partners. We propose a highly interdisciplinary joint doctorate program realized by bringing together world-leading experts in applied mathematics, high performance computing technologies, particle and nuclear physics, fluid dynamics and life sciences to appropriately train researchers in Europe to exploit high performance computing, advance science and promote innovation. Students will be trained in mathematical and computational concepts underpinning current and future numerical simulations in turbulent flows, computational biology and lattice quantum chromodynamics. The research projects are designed to enhance collaborations and interactions across these disciplines, integrating non-academic partners, and to develop methodologies that efficiently use large-scale numerical simulations on future high performance computer systems. Students who complete this training program will be versatile to undertake highly interdisciplinary projects, well positioned to embark on a successful career in academia or the industrial sector.

Keywords: computational sciences lattice qcd,turbulent flows,computational biology,infectious diseases,hpc architectures,algorithms
Terahertz Ultra-Short Pulses from Self-Induced Transparency Modelocked Quantum Cascade Lasers (TERAULTRA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The terahertz (THz) frequency range in the electromagnetic spectrum lacks a compact semiconductor source of ultra-short pulses, suitable for applications including ultrafast spectroscopy, atmospheric science and stable THz frequency comb generation. Although the quantum cascade laser (QCL) is a promising compact semiconductor THz source, its success in creating ultra-short pulses is limited due to the inherent fast gain recovery time. There have been demonstrations of short pulse (>1 ps) generation from THz QCLs based on active modelocking, although the stability of the pulses is limited. Crucially, there has been no demonstration of passive modelocking of QCLs to date, which in principle can create pulses much shorter than 1 ps. The goals of the proposed TERAULTRA research are to break through this technological challenge, and create THz ultra-short pulses of <1 ps from QCLs using self-induced transparency (SIT) effects. Recently, it has been proposed that QCLs are the ideal tool to realize SIT mediated modelocking owing to their relatively long inter-subband coherence times, and, importantly, the possibility of interleaving gain and absorbing media with engineered dipole moments. While the gain medium produces gain, the absorbing medium absorbs the resonant light, suppressing the growth of the continuous waves, thereby creating short pulses. We will design THz QCLs with coupled gain and absorbing media that can initiate modelocking using SIT effects, for the first time. By simulating the gain recovery and dephasing times, dipole moments, and gain and absorption parameters, the stability of the modelocked pulses will be determined and understood theoretically. We will then demonstrate experimentally the first modelocked laser exploiting the SIT effect, based on a THz QCL with interleaved gain and absorbing media in the growth direction as well as based on independently-controlled two-section waveguide cavities, leading to pulse widths <1 ps.

Keywords: terahertz,quantum cascade laser,modelocking,ultra short pulse,self induced transparency
Morphogen-like properties of small RNA gradients: A new paradigm for the role of small RNAs in developmental biology (MorphGrad)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

This fellowship will investigate the mechanisms by which small RNAs function as novel intercellular messengers that provide important developmental signals. By manipulating various small RNA gradient and target parameters, the proposed research seeks to understand how small RNA gradients are interpreted into sharp gene expression domains. The findings from the proposed experiments will provide important insight into the patterning properties of small RNA gradients, and their role in conferring robustness to developmental programs in both plants and animals. The approach taken is a multidisciplinary one that integrates mathematical modelling with qualitative experimental data, generated from a novel reporter system and state-of-the-art confocal imaging and image analysis. The outcome will be a new paradigm for how miRNAs function in development, which will provide important insight into the patterning properties of small RNA gradients.

Keywords: small rna gradients,mathematical modelling,leaf development,adaxial abaxial polarity,mirna
Getting to the root of ageing: somatic decay as a cost of germline maintenance (GermlineAgeingSoma)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The trade-off between survival and reproduction lies at the core of the evolutionary theory of ageing. Removal of germ cells extends somatic lifespan implying that reduced reproduction frees up resources for survival. Remarkably, however, the disruption of germline signalling increases lifespan without the obligatory reduction in fecundity, thus challenging the key role of the survival-reproduction trade-off. Recent breakthroughs suggest that protection and repair of the genome and the proteome of the germ cells is costly and compromised germline maintenance increases mutation rate, which can reduce offspring fitness. Thus, expensive germline maintenance can be a missing link in the puzzle of cost-free lifespan extension. This hypothesis predicts that when germline signalling is manipulated to increase investment into somatic cells, the germline maintenance will suffer resulting in increased mutation rate and reduced offspring fitness, even if total fecundity is unaffected. I propose a research program at the interface of evolutionary biology and biogerontology that focuses on phenotypic and evolutionary costs of germline maintenance. First, I will genetically manipulate germline signalling to boost investment into soma and estimate mutation rate and competitive fitness of the resulting offspring using Caenorhabditis elegans nematodes. Second, I will employ experimental evolution in nematodes to assess the long-term evolutionary costs of increased germline maintenance. Third, I will use germline transplantation in zebrafish Dario rerio to directly test whether germline proliferation reduces investment into soma in a vertebrate. Understanding how increased investment into the soma damages the germline and reduces offspring fitness will provide a major advance in our understanding of ageing evolution and will have serious implications for applied research programs aimed at harnessing the power of germline signalling to postpone ageing.

Keywords: ageing,senescence,life history evolution,disposable soma theory,condition dependent mutation
Bringing a health claim to information: Measuring the impact of health data on the health outcomes of European citizens (BAHCI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 2
Project status: CLOSED

European Union Members States (EU-MS) share similar levels of development and access to care. Yet, key population health indicators vary widely across countries. The societal burden of these inequalities is high, and leveraging evidence to achieve better health outcomes is a priority. Within countries, Health Information Systems (HIS) are the cornerstone of public health interventions. In Europe however, health surveillance data are fragmented: EU-MS report different items to different international data collection exercises; there is variation between countries with regard to the amount of data collected, how it is generated, and its quality; and there are gaps in information. Whereas we have good mortality data, we are weak on morbidity data, on the quality of care for chronic conditions, and on evaluating patients’ experiences of disease. Overall, there is heterogeneity in the level of evidence that can be used by key stakeholders and in specific health-domains; and we do not know the extent to which differences in health information (HI) capacity might influence on the population burden of disease. This post-doctoral project aims to provide a “HI Impact Index” that could be used by EU public health agencies and policy planners to measure the uptake of evidence into policies and care, and ultimately their impact on population health overall and in priority areas for Europe: maternal and child health, chronic diseases, antimicrobial resistance, injury prevention, and patient reported outcomes and experiences. The research will be hosted at the Belgian Federal Research Institute for Public Health under the supervision of Professor Herman Van Oyen, coordinator of the upcoming European Joint Action on Health Information. This MSCA project is a unique opportunity for me to consolidate my credentials as a European public health researcher and expand my career possibilities beyond the perinatal health field.

Keywords: health information systems,health system performance,surveillance and monitoring,health indicators,european public health,ehealth,evidence based health interventions
Integrated and portable image cytometer for rapid response to Legionella and Escherichia coli in industrial and environmental waters (CYTO-WATER)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,France,United Kingdom
Call: First application and market replication (H2020-WATER-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 2368298.75
EU funding (EUR): 1896624.5
Participants: 6
Project status: CLOSED

The proposed project will deploy for the first time a new imaging cytometer platform capable of detecting minute quantity of micro-organisms in industrial and environmental waters. The platform is based on the integration of proprietary technologies available to the consortium partners: an automatic water concentration cartridge combined with a microfluidic cell will provide an adequate sample to a newly designed fluorescence image cytometer whose readings will be recorded and processed using a proper software interface. It will be validated for quantifying Legionella and Escherichia coli (E. coli) population within 120 minutes from obtaining the sample, overcoming in this way the main disadvantage of traditional methods used in laboratories, i.e. long time-to results which can currently last up to 12 days in the case of Legionella and 1 day for E. coli. The targeted detection limit will be 10-100 cells/L and 5-20 cells/100 mL for Legionella and E.coli, respectively. Also, the new imaging cytometer will have a portable form, a size similar to a smart-phone, which will increase its versatility and widen the possibilities of onsite applications. The relevance of the project is clear when one thinks about the high risk of legionellosis in some specific industrial environments, such as cooling waters, evaporative condensers and air conditioning systems and the fact that E. coli is one of the faecal pollution index commonly analyzed for monitoring the presence of waterborne pathogens and hence the quality of bathing waters. From a market perspective, more than 7 million of Legionella analyses are performed annually in Europe while E. coli level is included in all bathing water regulations in different EU countries. CYTO-WATER clearly falls into HORIZON 2020 topic WATER-1-2014/2015: Bridging the gap: from innovative water solutions to market replication and addresses Water Framework Directive (2000/60/EC) and in the Bathing Water Directive (2006/7/EC).

Keywords: lens free technology,in situ system,cost effective,e coli,legionella
Machine learning software to design personalized neoantigen vaccines tailored to specific vaccine delivery systems (MEDIVAC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Norway
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cancer remains a leading cause of disease and death worldwide. An estimated 14m new cancer cases were diagnosed in 2012 and 22m are predicted by 2023. Immunotherapy and particularly personalized neoantigen-based vaccines represent an exciting new weapon in the war against cancer, as they are specific to the tumor and potentially safer and more effective than other types of treatment. However, the design of neoantigen-based cancer vaccines is currently hampered by an inability to reliably select immunogenic neoantigens using the existing technologies. OncoImmunity proposes to develop disruptive software - MEDIVAC - for the rapid and intelligent design of neoantigen-based personalized cancer vaccines, tailored to specific vaccine deliver systems (VDS). The software will leverage a machine-learning framework being developed at OncoImmunity that addresses key prediction gaps in the field of neoantigen discovery. Preliminary testing of MEDIVAC´s prediction engine reveals that it can identify immunogenic neoantigens with an unprecedented level of accuracy, and at a fraction of the time and cost of competing wet-lab methodologies. The MEDIVAC technology will enable personalized cancer vaccine companies to make safer more efficacious vaccines in an affordable and clinically actionable timeframe, and will consequently help revolutionize the treatment of cancer. We believe the SME instrument is the ideal funding vehicle to enable OncoImmunity to overcome the remaining barriers to the market and establish the company as the leading provider of software solutions for guiding the design of cancer vaccines. Furthermore, the MEDIVAC software will help nurture and improve the competitiveness of European companies in the rapidly growing personalized cancer vaccine market, and ultimately help Europe to tackle a global cancer epidemic.

Keywords: personalized medicine,immunotherapy,cancer treatment,vaccines design,neoantigens,software
Ecological and Multifunctional Composites for Application in Aircraft Interior and Secondary Structures (ECO-COMPASS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Greece,France,France,United Kingdom,Portugal
Call: International cooperation in aeronautics with China (H2020-MG-2015_SingleStage-A, 2015)
Start date: 2016-04-01
End date: 2019-06-30
Duration (months): 39.0
Total project cost (EUR): 1893685.0
EU funding (EUR): 1893685.0
Participants: 9
Project status: CLOSED

Composites are important materials used in aircrafts due to their excellent mechanical properties combined with relatively low weight enabling the reduction of fuel consumption. Expensive carbon fibre reinforced plastics (CFRP) are used in fuselage and wing structures and increasingly replace classic metals. Glass fibre reinforced plastics (GFRP) are mainly used for the interior panels. All these composite materials used in aviation have one thing in common: they are man-made. Renewable materials like bio-fibres and bio-resins are under investigation for a long time for composites but they did not made it into modern aircraft yet. The project ECO-COMPASS aims to bundle the knowledge of research in China and Europe to develop ecological improved composites for the use in aircraft secondary structures and interior. Therefore bio-based reinforcements, resins and sandwich cores will be developed and optimized for their application in aviation. Furthermore the use of recycled man-made fibres to increase the mechanical strength and multifunctional aspects of bio-composites will be evaluated. To withstand the special stress in aviation environment, protection technologies to mitigate the risks of fire, lightning and moisture uptake will be investigated. An adapted modelling and simulation will enable the optimization of the composite design. Electrical conductive composites for electromagnetic interference shielding and lightning strike protection will be investigated as well. A cradle to grave Life Cycle Assessment (LCA) will be carried out to compare the new eco-composites with the state-of-the-art materials. 8 European partners will be involved in ECO-COMPASS. The duration of the project is three years.

Keywords: bio composite,bio fibre,bio resin,eco composite,multifunction,conductivity,composite,aviation,green,life cycle assessment