Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamical Systems and Reaction Kinetics Networks (DSYREKI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Slovenia,Hungary,Italy,Germany,Brazil,China,United States,Austria,Türkiye,Romania,Croatia
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 326600.0
EU funding (EUR): 326600.0
Participants: 16
Project status: SIGNED

The primary goal of the project is to advance the theory of dynamical systems governed by differential equations with multiple parameters, leveraging this enriched understanding to dissect mathematical models that mirror real-world phenomena and processes. Our exploration will span both qualitative and quantitative attributes of these systems, including their general structure, solution properties, bifurcations, stability etc. In a practical application of our theoretical insights and computational techniques, we will delve into the analysis of certain biochemical networks, with a focus on those integral to reaction kinetics. Employing a synergistic approach that melds symbolic and numerical computation, we aim to enhance the analysis of stability and bifurcations within intricate biochemical systems. This will be achieved by developing bespoke symbolic-numeric tools designed to uncover instances of multi-stability and bifurcations. Our qualitative and computational evaluations will serve dual purposes: elucidating established biological phenomena and forecasting emergent ones.Additionally, our research will extend to the emphasizing parameter estimation and the resolution of control dilemmas for biomedical applications. We will explore novel territories of positive and impulsive control, areas currently lightly tread in existing literature.This project is inherently interdisciplinary, seeking to fuse and expand upon the methodologies from mathematics, applied mathematics and reaction kinetics, alongside the computational algorithms of symbolic computation. Incorporating the principles of the Green Charter, our research will also emphasize sustainable practices and the development of simulations aimed at addressing and mitigating environmental impacts associated with the processes under study. Furthermore, this endeavor promises substantial training opportunities for early-stage researchers, fostering an environment conducive to learning and innovation.

Keywords: dynamical systems,ordinary differential equations,integrability,stability,limit cycle,bifurcations,reaction kinetics,biochemical networks,biomedical networks,control
Engaging the League of Nations in Protecting Turkey's Minorities (ELoN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

The ELoN project aims to assess the League of Nations' Minority Protection System (MPS) in the context of the interwar era in Turkey. Grounded in primary archival sources, this research examines the mechanics of the MPS and its influence on Turkey's minority policies, particularly in relation to the Lausanne Treaty of 1923. The study augments the broader understanding of the League’s MPS by bringing insights from the Turkish case. This research specifically delves into petitions submitted by minority individuals to the League MPS, adopting an interdisciplinary approach that integrates a variety of methodologies, including historical and legal perspectives. ELoN's primary objectives are threefold: a) Gather fresh data on the League's MPS operations in Turkey and compile these archival materials into a "Minority Petitions Database". b) Identify and analyse the political and legal discourses, pivotal concepts, and events that informed the League’s minority protection mandate on Turkey, including the implementation of the Lausanne Treaty. c) Reassess the existing literature, offering fresh theoretical insights on the League’s MPS in light of data specific to the Turkish context. Through these means, the research intends to provide a comprehensive understanding of the League's minority protection efforts in Turkey, placing them in the wider scope of interwar international politics and minority rights advocacy. These objectives will be met through three meticulously designed work packages. ELoN distinguishes itself as an in-depth study of the League's MPS jurisdiction and minority petitions pertaining to Turkey. This re-evaluation enriches academic dialogue and furnishes insights for addressing Turkey's multifaceted challenges. The specialised training and research opportunities will expand my current research and expertise and help me return to academia, placing me in a prime position to pursue a faculty position.

Keywords: the league of nations,turkey,minority rights in the interwar era,minority petitions,the history of international law and global governance
Decoding Dark Matter with Stellar Streams from Beyond the Milky Way (BeyondSTREAMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1686734.0
EU funding (EUR): 1686734.0
Participants: 1
Project status: SIGNED

One of the key questions driving astrophysics research today is the nature of dark matter, which comprises 80% of the matter in the Universe. Stellar streams are sensitive to the distribution of dark matter and to the population of dark matter subhalos in galaxies, both of which depend on the mass and interactions of the dark matter particle. My proposed work will use the wealth of incoming stellar stream data materializing over the next five years from the Nancy Grace Roman Space Telescope, the Vera C. Rubin Observatory, and the Euclid Space Telescope to measure dark matter halo masses, shapes and concentrations, as well as subhalo populations of external galaxies. I will lead a fundamental shift in the approach to stellar stream studies through statistical model-to-data comparisons between theoretical predictions from various dark matter candidates (cold, warm, wave-like, self-interacting) and the actual stream data. To achieve this goal, I will develop novel numerical techniques which model and fit multiple streams at once in multiple external galaxies, run state-of-the-art N-body simulations of disrupting globular clusters in dwarf galaxies to place theoretical constraints on the expected substructure, and carry out statistical comparisons between dark matter models and properties derived from the stellar stream data. I will rule out dark matter candidates that are inconsistent with the new stellar stream data, and by the end of the 60-month grant period, I will have the world-leading constraints on dark matter from stellar streams. This work provides an innovative method for mapping the otherwise invisible dark matter, and will constrain statistical properties of dark matter related to its nature and possible extensions of the standard model of particle physics.

Keywords: stellar streams
pRoducE Actionable poLicy Insights that enable a sound balance between Security and opEnness of the EU research and innovation ecosystems. (REALISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-12-31
Duration (months): 40.0
Total project cost (EUR): 429264.96
EU funding (EUR): 429264.96
Participants: 4
Project status: SIGNED

European and global Research and Innovation Ecosystems (RIEs) are at risk. Planetary tensions have exposed EU vulnerabilities and elevated technology sovereignty to the top of policy agendas. Open RIEs are now contested spaces increasingly being viewed through the lens of protectionism, jeopardizing science as a universal and public good essential for addressing global challenges. Achieving a sound balance between security and openness (S&O) is imperative. To date, however, the lack of scientific evidence prevents us from holistically addressing how technological sovereignty is affecting both the operations of RIEs and the geography of innovation, while the research community struggles with adoption and implementation of fragmented and often impractical guidance. Using the semiconductor industry as a testbed, the Fellowship combines deep theoretical grounding with a strong applied focus. Based on an interdisciplinary multi-methodological approach, the Overall Objective is to pRoducE Actionable poLicy Insights that enable a sound balance between Security and opEnness (REALISE) in EU RIEs. REALISE’s tridimensional impact is intertwined with the pursuit of a holistic approach that advances world-class knowledge and develops governance mechanisms for balancing S&O in RIEs. This approach, developed with contributions from relevant stakeholders – including the private sector – aims to be responsive to real needs, turning RIEs from existing pockets of excellence into thriving ecosystems. Training at prestigious academic institutions in the US and EU, along with the placement at INSIDE (a leading Industry Association focused on Intelligent Digital Systems), will equip the researcher with amplified and cross-cutting skills to become a hybrid investigator to both steer scientific research in academia and support STI domains of policy-making for industrial organizations and institutional settings, while facilitating the dialogue between different actors of the EU RIEs.

Keywords: research and innovation ecosystems,research security,tech war,semiconductors,new economic statecraft,sovereignty,globalisation,economics of innovation
HYPE: Assessing the central influence of hyperarousal in shaping trauma outcomes. (HYPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

Up to 70% of people will experience a traumatic event in their lives. Following such events, post-traumatic stress disorder (PTSD) emerges as the most common adverse psychological consequence, affecting 10-15% of survivors. Despite available therapies, nearly 40% of patients continue to exhibit hyperarousal symptoms such as irritability, risk-taking behaviors, sleep disturbances, concentration difficulties, and an enhanced startle response. Several cognitive processes (e.g., attentional biases, emotion recognition, executive functioning) have been investigated to understand the mechanisms behind isolated hyperarousal symptoms, such as hypervigilance or startle responses. However, the exact nature and mechanisms through which these cognitive processes influence the whole spectrum of hyperarousal symptoms remain largely unknown. In response, the HYPE project aims to: (1) offer the first comprehensive evaluation of the cognitive processes underlying various hyperarousal symptoms, (2) examine the effects of gender and repeated traumatization on these processes, and (3) longitudinally assess the predictive value of these cognitive processes on the development and persistence of other PTSD symptoms. By utilizing eye-tracking (ET), electroencephalography (EEG) and machine learning techniques, these studies will provide precise and reliable assessments of these intricate cognitive processes and highlight new therapeutic targets with direct benefits for patients. While both the host-lab and myself are specialized in PTSD, the synergy between the host lab's expertise in EEG and affective neurosciences, and my knowledge of ET and advanced statistical methods, makes this ambitious project mutually beneficial. Complementarily, the training activities planned will not only improve my research skills but also my independence, mentoring, and communication abilities, preparing me for a young leader position able to transfer knowledge to both specialized and not-specialized audience.

Keywords: ptsd,hyperarousal,stress,eye tracking,eeg,attentional biases
Genetics of long-distance migration (MigraGenes)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

It is firmly established that the migratory behaviour of animals is largely genetically hard-wired. However, we do not know the genes involved, where these are expressed and how the genetic code guides individuals to fly in a specific direction for more than a month, across deserts, mountain ranges or oceans, to finally reach a wintering area on the other side of the globe. To approach these gaps of knowledge, I propose a coherent research program that builds on my long-term research of migratory genetics. I will use different species of migratory songbirds to investigate three key questions in migratory genetics: (1) how does the inherited migratory program instruct the juvenile on its first journey?, (2) which are the genes that control migratory behaviour and when and where are they expressed? and (3) how have migratory genes evolved across species with different migratory behaviours? The three parts of this program are designed to maximize gain of new knowledge by combining large scale field studies with cutting-edge molecular techniques. I will carry out a translocation experiment and combine it with state-of-the-art tracking methodology to determine how direction of navigation is inherited. By profiling the expression patterns of genes in the brain before and during the first phase of migration using both spatial and single-cell transcriptomics, I will uncover the mainly unknown migration genes and regulatory networks as well as where in the brain these are expressed. Through comparative genomics on the species-rich genus Phylloscopus (in which migration has been lost, gained and increased in distance multiple times during its diversification), I will explore how migration genes have evolved in concert with the migratory behaviours. In summary, this project has the potential to finally identify the elusive migration genes and add milestones in our understanding of the genetic architecture and regulation of long-distance migration.

Keywords: bird migration,orientation,satellite tracking,translocation experiment,comparative genomics,gene expression,
Unveiling the functional outcome of single nucleotide polymorphisms and variants in oligodendroglia in multiple sclerosis (SingleMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 3182846.0
EU funding (EUR): 3182846.0
Participants: 1
Project status: SIGNED

Multiple sclerosis (MS) is a neurological disease characterized by autoimmune attack targeting oligodendroglia (OLG) in the central nervous system (CNS), and in particular their myelin, which ensheaths neuronal axons. Genome-wide association studies (GWAS) have led to the identification of hundreds of single-nucleotide polymorphisms (SNPs) and variants that are associated with MS risk. Many of these are located near genes associated with immune cells, indicating a key role for these cells in MS. Using single-cell omics approaches, we recently found that OLG present chromatin accessibility or express genes associated with some of these SNPs/variants, both in health and disease. Here, we hypothesize that OLG have a more active role in MS than previously anticipated, and therefore we will determine the function of MS SNPs/variants in OLG in the context of MS, using humanized mouse models, patient samples and new single-cell omics techniques recently developed in my group. We will 1) characterize in-depth the transcriptomic and epigenomic landscape of human and mouse OLG in the context of MS, to identify putative genes affected by the SNPs/variants; 2) perform CRISPR-guided editing of a cohort of the identified SNPs/variants in human OLG, and determine the consequences of the editing at a) an epigenomic and transcriptional level, linking specific SNPs/variants to their bona-fide target genes, and b) a functional level, by performing an array of functional assays targeting myelination, cell survival, and immune function, both in vitro and in humanized mouse chimeras in which engineered human OLG have been transplanted. We will use single-cell and spatial omics technologies, such as nanoCUT&Tag and spatial CUT&Tag, among others which we have recently developed in my research group. The results of this project will yield unique insights into the role of OLG and the identified SNPs/variants in MS, and thereby pave the way to novel therapeutic avenues for this disease.

Keywords: multiple sclerosis,oligodendrocytes,glia,single cell omics,epigenomics,chromatin architecture,snps,variants,genome wide association studies
Uncovering Protective Mechanisms in Pancreatic β-Cells to Enhance Their Survival in Type 1 Diabetes (Beta_cell_protection)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of pancreatic β-cells, leading to insulin deficiency and severe complications, including cardiovascular disease, neuropathy, and vision impairment. Despite extensive research, the exact cause of T1D remains elusive, and the disease remains incurable. Emerging evidence suggests that β-cells may play an active role in their own demise, alongside the well-documented immune attack. Recent findings have identified protective genes within β-cells that may help them resist immune-mediated destruction. This project aims to investigate the role of three protective genes—HLA-E, IDO1, and BiP—in preserving β-cell function and survival under autoimmune stress. These genes were identified via a bioinformatic approach that analysed single cell RNA sequencing of β-cells from individuals affected by T1D. The study will begin by modulating the expression of these genes in human EndoC-βH1 cells and human islets, followed by an immune attack model of co-culture with the activated CD8+ T-cells. The goal is to determine which gene(s) offers the most significant protection against β-cell destruction. Subsequently, the most promising gene(s) will be further evaluated in stem cell-derived β-like cells, which will undergo in vivo testing in immune incompetent NSG mice to mimic more physiologically relevant conditions. The implanted cells will be evaluated by in vivo imaging using an intravital microscopy platform. By silencing or overexpressing these genes, we aim to elucidate the mechanisms that contribute to β-cell resilience, providing insights that could lead to novel therapeutic strategies for enhancing β-cell survival in T1D patients. This project represents a critical step forward in understanding the interplay between β-cells and the immune system in T1D. It has the potential to uncover new targets for therapy, ultimately improving the quality of life for individuals living with T1D.

Keywords: cells,apoptosis,protective genes,cell homeostasis,type 1 diabetes,interferons
Niels Bohr for the 21st Century (BOHR21)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Niels Bohr has been hugely influential both in physics and outside physics, but he is also hugely misunderstood, partly because a few of his writings have been overstudied at the expense of many others. This ERC project is devoted to his philosophical legacy, and will establish an unprejudiced understanding of Bohr, building on a current revival of interest in Bohr’s ideas in the philosophy of physics, and extending it among other things to his wider influence in other scientific disciplines, specifically in biology, and on general debates such as on science and objectivity. The project will systematically exploit the resources of the Niels Bohr Archive in Copenhagen, which has only recently started digitising its collections. This ERC project has the ambition to rectify historical misjudgements and to build bridges between physics and philosophy, between different schools in philosophy of physics, between philosophy of physics and philosophy of biology, and even between analytic philosophy and continental philosophy. The relevant resources are only now becoming more widely available. It is a large and methodologically novel project, combining philosophy and history, involving the systematic study of extensive sources, and including applications to philosophy of physics, philosophy of biology and general philosophy of science. Historically informed analysis has long proved to be an important tool in the philosophy of science, and the project will lead the way in applying a historically accurate understanding of Bohr’s thought to 21st-century debates.

Keywords: niels bohr,physics,biology,complementarity,interpretations of quantum mechanics,objectivity,emergence,kantianism