Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chromatin re-organization in response to replication stress (ChOReS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Background and unmet need: The mammalian genome is a highly organized structure where distinct chromosomal domains occupy discrete territories and position in a non-random fashion. Genome organization also determines the proper functioning of various biological processes, including DNA replication. Genome organization has been widely studied in the context of gene regulation, while recently the role of genome organization in mediating DNA damage repair at DSB sites has also come to light. However, there is scarce information on how newly replicating region is organized in response to replication stress. Hypothesis to be tested: My hypothesis is that stalled replication forks, especially at the regions prone to acquire breaks, undergo compartmentalization/re-organization within the 3-D nuclear space in response to replication stress to allow efficient fork protection and fork restart ability. Objectives: This unique multidisciplinary project will yield critical information to reveal hidden connections of chromatin organization, replication fork stability and chemoresistance. With this ERC project, I will determine for the first time i) the mechanistic insights of chromatin organization changes mediated by chromatin remodeling activity in response to replication stress, ii) identify novel chromatin mobilizers associated with replication forks and iii) determine the significance of chromatin reorganization to cope with replication stress for establishing resistance towards chemotherapeutic drugs in cancer cells and patient samples. Expected Outcomes: My project will not only advance our fundamental knowledge on spatial & temporal reorganization of chromatin architecture containing stressed replication forks, but it also has a high potential to contribute to identifying novel targets aimed at chromatin organizers that mediates resistance towards replication stress inducing chemotherapeutics.

Keywords: replication stress,chemotherapy,3 d chromatin organization,replication fork stability
Modulating non-canonical functions of microRNAs in cardiovascular disease (MONOFUN-CV)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2499740.0
EU funding (EUR): 2499740.0
Participants: 2
Project status: SIGNED

Atherosclerosis is the major underlying pathology of cardiovascular diseases (CVD), which remain the leading cause of death worldwide. The relevance of miRNAs in vascular biology, atherosclerosis and CVD has been well established. Our discovery of an aptamer-like binding of an endogenous miRNA to proteins, namely that of nuclear miR-126-5p to caspase-3, as facilitated by the RNA-binding protein MEX3A has extended the classical paradigm of miRNA function in the RISC, adding a new layer to the mechanisms enacted by miRNAs. Taking MEX3A as a starting point, MONO-FUN-CV aims to (1) characterize cell-specific contributions of MEX3A to mouse atherosclerosis and an association of MEX3a risk variants with human atherosclerosis, to dissect the specificity of its cross-talk with miR-126-5p, and to unravel potential MEX3A-based therapeutic options; we will (2) conduct an unbiased analysis of miRNAs affected by MEX3A (e.g. by eCLIP), elucidate the structural basis and mechanisms controlling MEX3A functions, e.g. ternary complex formation with AGO2, nuclear shuttling, and involvement of other adaptors (proteins, RNA); and (3) we will clarify structural bases and sequence requirements of miR-126-5p interactions with caspase-3, and its physiological relevance using novel in vivo models, as well as screen other miRNAs and proteins engaging in functional interactions, such as miR-210-5p and HIF-1α, to define templates for novel molecular modulators, e.g. aptamers. All aims include unbiased strategies to discover related miRNAs (e.g. nuclear, MEX3A-interacting) and adaptors contributing to the control of protein functions. These aims are highly interconnected and may enable groundbreaking insights into non-canonical mechanisms of miRNAs and their translation into novel approaches for therapeutic targeting of CVD and beyond.

Keywords: microrna,atherosclerosis,rna therapeutics
FOod and nutritiOn Data-driven innovation respectful of citizen's Data SovereIgnTY (FOODITY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Ireland,Spain,France,Estonia,Greece,Netherlands,Austria,Romania
Call: Piloting approaches and tools to empower citizens to exercise their “data rights” in the area of food and nutrition (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 3999937.5
EU funding (EUR): 3999937.5
Participants: 8
Project status: SIGNED

The data economy holds great promises for making food systems more sustainable. Data collected in digital solutions in the food and nutrition domain could be used by food producers, distributors, retailers to innovate towards more environmentally-friendly activities. However, the currently used platforms are closed, and do not allow citizens to exercise their rights to personal data sovereignty. Moreover the closed aspect of these platforms hinders the possibility to use these data for common good even if users gave their consent to share their anonymised personal data. It is time for Europe to ensure a healthy ecosystem of Digital Solutions for food and nutrition that respect citizens' right to personal data sovereignty. FOODITY will run a 2M€ pilot development program funding 12 Industry and research collaborations to develop pilots demonstrating the potential of data-driven innovations in health and nutrition, engaging citizens in their development. The pilots will demonstrate the potential of user’s personal data in health and nutrition solutions to contribute to more just and environmentally-friendly food systems, reaching over 200,000 citizens in our communication actions. The FOODITY Pilot development program we provide it's beneficiaries with a set of value adding services including one-to-one mentoring, training on technical business and legal topics relevant, as well as technical support into assets to which beneficiaries can use as building blocks the development of the pilots. FOODITY builds on the PROTEIN H2020 project will provide state-of-the-art tools and software components as building blocks for the development of personalised nutrition solutions, and the PoSeID-on H2020 project Provides a deployment-ready solution for trustworthy secure large-scale data sharing transactions, full GDPR compliance and relying on the centralised technologies and digital identity, thus guaranteeing the personal data sovereignty of the end users.

Keywords: personal data,personalised nutrition,user s control over personal data,data rights,citizen engagement,citizen empowerment,sustainable food systems
Lattice QCD simulations at the dawn of European Exascale Computing (LEEX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1993375.0
EU funding (EUR): 1993375.0
Participants: 1
Project status: SIGNED

Large-scale simulations of lattice Quantum Chromodynamics (QCD) can provide crucial input for searches of new physics at the precision frontier, like in the calculation of the hadronic contribution to the anomalous magnetic moment of the muon. To find evidence of new physics beyond the current knowledge provided by the Standard Model will require to reach per-mille precision. Attaining such accuracy in the hadronic contribution to the anomalous magnetic moment of the muon in lattice QCD can only be achieved by controlling lattice systematics, such as logarithmic terms in the continuum extrapolation, finite volume effects and exponentially increasing noise at large time distances. Simulating gauge ensembles at lattice spacing a<0.04 fm is impossible with current algorithms due to topological freezing. Generative models based on gauge equivariant flows can unfreeze the charge but scale badly with the volume, limiting, up to now, their applicability to toy models. We propose a solution to overcome topological freezing and suppress exponential noise by developing scalable algorithms for lattice QCD simulations closer to the continuum limit and at physical quark masses based on domain decomposition. By combining machine-learned flow proposals with hierarchical accept/reject steps of the factorized fermion determinant, ensembles at very small lattice spacings can be generated using upcoming european exascale supercomputers. We will implement multi-level sampling techniques within a flexible framework to enable good performance of the here developed novel Markov Chain Monte Carlo algorithm on exascale systems. By the newly generated gauge ensembles lattice QCD will provide a leap in the precision frontier thereby critically contributing in the unraveling of new physics.

Keywords: lattice qcd
Eye-tracking and AI for Enhanced Teaching (EYE-TEACH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Finland,Spain,Belgium,Netherlands,Malta,Italy,Germany,Sweden,Poland
Call: Assessing and strengthening the complementarity between new technologies and human skills (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2999981.25
EU funding (EUR): 2999981.25
Participants: 11
Project status: SIGNED

Eye-tracking and AI for Enhanced Teaching (EYE-TEACH) Recent education assessments (PIRLS, PISA) show a significant decline in reading comprehension amongst students in many European countries. The EYE-TEACH project is an initiative integrating artificial intelligence (AI) and eye-tracking (ET) that aims to transform educational practices and empower European teachers with new pedagogical skills for assessing and supporting their students' reading comprehension. The project addresses issues such as the post-COVID-19 educational challenges, mounting teacher workload and teacher shortages across Europe. Eye tracking, although not without limitations, has proven its worth in educational research, offering insights into students' reading behaviours, cognitive load, and emotional engagement. It differentiates between various levels of reader comprehension, making it a valuable tool for personalised education. Complex eye-tracking data translated into intelligible output by AI and supported by a robust ethical and data privacy framework can provide teachers with actionable insights, aiding the selection of effective pedagogical strategies. EYE-TEACH reaches beyond the state of the art by involving teachers and education practitioners early in the development process. By mapping educators' acceptance and readiness to adopt such novel technologies and highlighting the role of perceived ease of use and usefulness, the project has real potential to transform educational practices. The final joint result of the project will be a comprehensive resource of training materials and guidelines for using and implementing this technology in education, including benefit and risk assessments, and considerations of privacy and ethics issues. By empowering teachers with an AI-assisted ET-analytics tool and training materials, the project aims to contribute positively to the future of education in Europe.

Keywords: pedagogical skills,reading comprehension,eye tracking,artificial intelligence,educational technology
Holistic Efficient Arrhythmic Risk Twinning for Post-MI Stratification (HEART-TWIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Myocardial infarction (MI) leads to permanent myocardial scarring, significantly increasing the risk of sudden cardiac death (SCD) due to ventricular arrhythmias (VAs). Current risk stratification methods using ejection fraction (EF) are inadequate, as many SCDs occur in patients with preserved EF, and many implanted defibrillators remain unused. Physics-based mechanistic cardiac digital twins (CDTs) can predict VA risk stratification (VARS). CDTs are computational models that integrate multimodal clinical data, such as MRI and CT, to predict VA risk by simulating cardiac properties like myocardial conduction speeds and activation sites, which cannot be easily measured with standard diagnostics. The HEART-TWIN (Holistic Efficient Arrhythmic Risk Twinning for Post-MI Stratification) project aims to develop, validate, and apply efficient CDT strategies for post-MI arrhythmic risk prediction using non-invasive clinical data. The project is structured around three main research objectives (ROs). RO1 will focus on characterising the largest multimodal dataset (~500 post-MI patients) using ECG and MRI data, enabling the creation of robust clinical phenotypes and providing data for CDT development. RO2 will develop an open-source CDT framework validated through verification and validation with uncertainty quantification (VVUQ). Efficient electrophysiology models, such as the pseudo-diffusion reaction-Eikonal model, will be used to simulate ECGs and enhance the accuracy of VA risk predictions. RO3 aims to link CDT simulations with clinical outcomes to achieve deep phenotyping of post-MI patients. By leveraging these data, the project will enable AI-driven discovery of phenotypic subgroups and improve VARS through personalised, mechanistic insights. HEART-TWIN will produce the most advanced open-source digital twin framework for post-MI patients, optimising clinical decision-making and risk stratification, ultimately paving the way for precision cardiology.

Keywords: cardiac digital twins cardiac electrophysiology modelling and simulation patient specific modelling inverse electrophysiology eikonal model bayesian inference ecg mri cardiac arrhythmias
POLINA Hop-on (POLINA Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Ireland,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 34.0
Total project cost (EUR): 592020.0
EU funding (EUR): 592020.0
Participants: 2
Project status: CLOSED

POLINA aims to leverage photolithography as a transformative technology for the medical device industry and next-generation green electronics. Through an ambitious, multidisciplinary approach, POLINA seeks to pioneer breakthroughs in photopolymerisation of amino acids and their lithographic structuring, leading to novel materials with unique biological properties. This innovative approach combines a radically new, light-sensitive poly(amino acid) (PAA) material platform with established and emerging photolithographic patterning techniques. POLINA’s science-towards-technology breakthroughs will be demonstrated in three applications: micropatterned cell surface models, spheroid arrays for disease modeling, and cell-laden implants. The POLINA Hop-on project seeks to fully unlock POLINA’s potential by developing a new class of biorthogonal click-chemistry PAAs to create groundbreaking macroscale human-cell living materials. UNIVERSIDADE DE AVEIRO’s cutting-edge expertise in tissue engineering, bioorthogonal click-chemistry biopolymers and high-resolution bioprinting will enable the fabrication of photolithographically programmable geometries and tissue-like cell densities. Their participation will level up POLINA PAA materials to a new technological maturity level, while broadening their applications in precision photolithography processing. POLINA Hop-on is a key step towards achieving POLINA's ultimate goal of creating safer, smarter, and affordable medical devices, while laying the foundation for future innovations in biomedicine and (bio)electronics.

Keywords: amino acids,poly amino acid s,click chemistry,photolithography,living materials,2d 3d structures,medical devices
HIGH YIELD PHOTOVOLTAIC ROOFTOP SYSTEMS TO REDUCE EUROPEAN DEPENDENCE ON SOLAR PANEL IMPORTS (VECTHOR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The VECTHOR technology introduced by FutureVoltaics is an innovative solar photovoltaic (PV) design enhancing energy production during periods of energy demand. VECTHOR's unique configuration features a patented design combining HJT east-west vertical bifacial panels with advanced patterned optical reflectors. This setup maximizes the capacity factor of PV systems close to the theoretical limit by keeping the solar panels optimally illuminated at most times. VECTHOR addresses critical limitations of existing PV systems, such as i) misalignment of energy production with demand, ii) low electricity prices during times of high solar energy availability, and consequently low economic return for conventional PV systems, iii) low capacity factor (ratio of actual electrical energy output over a given period of time to the theoretical maximum electrical energy output). VECTHOR reduces by half the payback time of the conventional PV systems typically used in warehouses and large area rooftops. Moreover, VECTHOR's configuration offers protection against environmental factors such as dirt, hail, and overheating. FutureVoltaics has developed proprietary software (FVLIB) to optimize the system configuration based on the needs of each customer. Extensive testing and validation at the Institute of Micro and Nanotechnology (IMN-CSIC) and partnerships with leading industry players have demonstrated VECTHOR's superior performance, with energy yields surpassing conventional rooftop systems by up to 80%. VECTHOR is perfectly aligned with the priorities of EIC and the Renewable Energy Sources challenge as it increases by up to 80% the amount of energy produced by each solar panel. This significantly reduces European dependence on solar panel imports and their whole life cycle enviromental impact. VECTHOR represents a disruptive and groundbreaking advancement in solar PV technology, offering a more efficient, cost-effective, and durable solution for renewable enenergy production.

Keywords: energy independence grid stability higher return on investment lower environmental impact less critical materials solar tracking without moving parts
A NEXT-GEN AMMONIA CRACKING: UNLOCKING HIGH H2 RECOVERY, ON DEMAND, LOW-CARBON HYDROGEN (H2SITE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Context – The role of Ammonia as an Enabler of the Hydrogen Economy Hydrogen is crucial for transitioning to a net-zero economy, especially for hard-to-decarbonize industries and the maritime sector. However, its transportation and storage pose significant challenges, adding up to 300% to its production cost . Ammonia, with its high hydrogen storage capacity and existing global distribution infrastructure, offers a promising solution for hydrogen on demand. The problem – Ammonia cracking is not optimized Hydrogen can be converted to ammonia and back again by conversion and cracking processes. While conversion processes are optimized, current ammonia cracking technologies are inefficient, costly, and heavily reliant on fossil fuels, making them unsuitable for widespread adoption. Solution – Optimized, scalable, autonomous, low GHG, low cost, on-demand hydrogen Our project at H2SITE aims to revolutionize ammonia cracking with our novel membrane reactor technology. This technology integrates ammonia separation in a single step at lower temperatures, reducing both CAPEX and OPEX. It is catalyst agnostic, modular, and can be integrated with an ammonia burner, making it highly efficient and scalable. By producing just 0.5 gCO2eq/MJ (post-EIC) compared to 25 gCO2eq/MJ from conventional processes, while our current level stands at 2.7 gCO2eq/MJ, our solution achieves at least 95% GHG reduction compared to natural gas-based alternatives, with the potential for zero emissions. EIC Project – Bringing Ammonia Cracking to Industrial and Maritime Applications We are currently at TRL6 and need support from the EIC to develop and demonstrate a 1 ton per day MVP in the Port of Antwerp. This will enable us to scale up our technology, and adapt it for the maritime segment and other applications, representing a €77Bn market opportunity.

Keywords: ammonia,hydrogen,ammonia cracking,ammonia burner,membrane reactor,energy import hubs,maritime transport,industry