Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rhythms of the Female Heart: The Impact of Cycling Sex Hormones on Cardiac Signaling and Interoception (FEM-CYCLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Every month, over two billion females around the world menstruate. In addition, an estimated 400 million females globally use hormonal contraception ("the pill"). Consequently, from puberty to menopause, the female heart and brain are continuously exposed to cyclical changes in sex hormones, e.g., associated with the menstrual cycle or hormonal contraceptive use, with direct implications for neuro-cardiac health. Both psychological symptoms and specific cardiac arrhythmias show an increased prevalence and burden during specific phases of the menstrual cycle. Given this association, it becomes evident that the menstrual cycle is a key factor in understanding the heart-brain connection and its effect on psychological and cardiac health. This project aims to reveal how two recently identified markers of the heart-brain axis relevant for psycho-cardiac health, i.e., cardiac signaling (denoting neural responses to cardiac signals) and cardiac interoception (denoting conscious awareness of signals arising from the heart), varies with sex, menstrual cycle phase, and hormonal contraceptive use. To this end, we will (1) utilize a novel psychophysiological task to assess cyclical and group changes in heartbeat detection; and (2) perform concurrent electrocardiogram and electroencephalogram recordings to study cyclical fluctuations in the heartbeat evoked potential (HEP). A male reference group will be adopted to provide a basis for comparative analyses. By adopting a multidisciplinary approach and integrating knowledge from cardiac psychophysiology, biological psychology and neuroendocrinology, to study the specific role of cycling female sex hormones on the heart-brain axis, this research aims to provide critical insights into the well-known sex discrepancies in mental and cardiovascular health, as well as the exacerbation of psychological and cardiac symptoms during specific menstrual cycle phases.

Keywords: cardiac interoception,female sex hormones
Transatlantic crossroads Lab (TransatlanticLab)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,France,Portugal,Germany,Italy,Cabo Verde,Dominican Republic,Colombia,Costa Rica,Jamaica,Argentina,Cuba,Cameroon,Côte d'Ivoire,United States,Mexico,Sao Tome and Principe
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 1803600.0
EU funding (EUR): 1803600.0
Participants: 24
Project status: SIGNED

TransatlanticLab reexamines colonial and post-colonial interactions within the transatlantic space, using the Atlantic as a historical laboratory to explore colonial domination and racialist ideologies. The project focuses on how these dynamics, emerging from the plantation economy in the greater Caribbean, were maximised on both sides of the ocean. It addresses how race was constructed through economic practices, becoming an instrument of social oppression embedded in thought and language. Beyond traditional European mechanisms like slavery, forced labour, and racialism, the analysis includes their impacts on European territories. It rethinks colonial regimes, historicises European domination languages, and examines intermediaries' roles in maintaining colonial power. TransatlanticLab aims to surpass current decolonial theories and simplistic understandings of racism as merely a system of prejudiced morality that can be corrected through education. The hypothesis posits that racialism and racism evolved tied to the plantation economy, flourishing in the Americas and the Caribbean, and later used in European colonialism in Africa. Our argument is multifold: 1-Colonialism roots in Africa and racism link to Americas' plantation systems. 2-Enslavement created "Black" and "White" hierarchical systems. 3-Pseudo-scientific racialism naturalised this system. 4-This ideology supported European racist politics by the "Scramble for Africa." 5-African colonialism depended on Caribbean plantation economies. 6-European scientific exploration and tropical determinism led to environmental racism. TransatlanticLab will provide new insights into the long-term transformations of the tools of imperialism and colonialism. In order to comprehend the impact of these instruments of power, we will analyse them in their contemporary social contexts, considering history, geography and environment. This approach helps understand racial ideologies and colonial practices, and their impact.

Keywords: transatlantic world,colonialism,slavery,race,history of science,eugenesic,environment,heritage,literature,arts,representations of otherness,auto representations
LEAD ADJUVANT PROBE AS A DUAL TECHNOLOGICAL TOOL TO ADVANCE NEXT-GENERATION VACCINE DEVELOPMENT (ADJUPROBE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The goal of ADJUPROBE is to build upon a major discovery made within the ERC-2016-STG-716878 project to validate and valorise our dual synthetic technological tool, moving it forward to boost vaccine efficacy from technical development to commercialisation. We will exploit our lead adjuvant in further preclinical settings in terms of scaled-up production, functional validation, and additional vaccine trials in mice with clinically relevant antigens. In parallel, we will confirm and advance the innovation of our technology towards commercial exploitation by implementing a multifaceted valorisation plan supporting the technical development. The plan includes consolidation of intellectual property (IP) rights and IP position, engagement of pharma/biotech partners and investors, as well as verification of the potential of spin-off creation. Our adjuvant technology based on a scalable semi-synthetic saponin has demonstrated its potential as a dual tool with superior performance to the approved, natural QS-21 adjuvant. These breakthroughs have been provisionally protected via a priority patent application and have also attracted the interest of important biotech/pharma companies. ADJUPROBE will provide decisive proof-of-concept for preclinical development and validation of our technological tool, including synthesis upscaling and confirmation of the superiority of our adjuvant lead in disease-related vaccines benchmarked against QS-21. Moreover, key valorisation outcomes based on successful implementation of our transference and commercialisation plan, such as advancing IPR protection and spin-off creation together with fruitful pharma and investor partnerships, will facilitate market entry and traction for ADJUPROBE in the near future.
Chemistry improvement thanks to Separation by membrane processes (ChimSep)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Poland,Portugal,Germany,Netherlands,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 3379543.2
EU funding (EUR): 3379543.2
Participants: 17
Project status: SIGNED

Two of the major hurdles for the chemical industry transition toward the “chemical factory of the future” are the ability to design (i) efficient and selective catalytic transformations of renewables and (ii) eco-efficient separation processes to retrieve and purify the product(s) and catalyst(s). Future generations of researchers (academic &industry) will need to be trained and equipped with these expertise that constitute the main goal of ChimSep. ChimSep aims at establishing an inter-disciplinary and inter-sectoral European Joint Doctorate programme offering challenging and innovative research and training in sustainable catalytic synthesis and sustainable membrane separation processes. The network is based on 7 academics, 7 industrials partners and 1 bio-economy cluster. Such a network gathering internationally renowned experts in the two topics has never been built-up and carried in Europe. ChimSep will implement an unprecedented and high-level training programme in order to provide the 13 Doctorate Candidates (DC) with a double culture/competency in both chemical synthesis and membrane separation. The capability of future European researchers to work at the interface of different domains and to master the entire process chain is a key to increase the competitiveness of European chemical research and industry by the progressive replacement of distillation by membrane processes at least 10 times less energy consuming. Each DC will benefit from training through a research project conducted in two academic sites plus a secondment in industry. DCs will acquire complementary soft skills provided during network events, interdisciplinary summer schools, workshops and a collective research project. All DCs will be hosted few months by industrials. Furthermore, ChimSep has designed an innovative supervision policy to favour fruitful exchanges between DC and senior scientists providing an exceptional training experience, through extensive research and complementary skills development.

Keywords: membrane separation processes,green chemistry,renewable resources
The politics of alter-biotic innovation: Examining the making of alternative regimes of biomedical innovation in response to the global health crisis of antimicrobial resistance (ALTERBIOTIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1499173.0
EU funding (EUR): 1499173.0
Participants: 1
Project status: SIGNED

Modern antibiotics greatly contributed to fighting infectious diseases. However, today we face a resurgence of deadly drug-resistant microbes due the excessive use of antibiotics – a phenomenon known as antimicrobial resistance (AMR). AMR is not only a pressing public health problem, but a unique and fundamental crisis that profoundly challenges existing regimes of pharmaceutical innovation that have for long provided societies with powerful, easily available antibiotics. However, long-term solutions to AMR not only require new potent drugs, but also alternative scientific, economic and regulatory approaches in the development, distribution and deployment of antibiotic therapies – captured here by the term ‘alter-biotic innovation’. Yet, much-needed social science research on this complex innovation challenge is glaringly absent. ALTERBIOTIC will break new ground by developing the unique research perspective of ‘alter-biotic innovation’ to conceptualize and investigate how alternative approaches are being envisioned, negotiated and developed to overcome the limitations of existing antibiotic regimes. It will focus on the major antimicrobial partnership initiatives launched in response to AMR. In addition to product development, these initiatives drive a broader normative and political agenda: to radically rethink and alter regimes governing the development, valuation, regulation and use of antimicrobials in more sustainable and equitable ways. ALTERBIOTIC conducts a multi-sited analysis of alter-biotic innovation, based on qualitative-interpretive methodologies and ethnographic sensibility. It employs an ambitious case study design integrating ethnographic vignettes with in-depth case studies through a combination of document analysis, interviews and participant observation. This research not only provides a fresh perspective to the social studies of AMR, but also novel approaches to study ‘innovation societies’ amid the multiple sustainability crises they confront.

Keywords: sociology of pharmaceuticals,social studies of biomedicine and the life sciences critical innovation studies biopolitics,global health
Dynamic Network Toolbox for Data-Driven Model Learning and Diagnostics (SysDyNetTool)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-04-01
End date: 2025-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Increasing demands on the safe and efficient operation of engineering systems require the ability to model, monitor, optimize and control complex dynamic systems that are spatially interconnected as networks of dynamic subsystems. Examples can be found e.g., in distributed (smart) power systems, industrial production processes, transportation networks, biomedical systems, etcetera. Operational decisions are being made on the basis of models and data, while keeping the network models up-to-date over time is key for the ability to guarantee safe, efficient and robust operation. While sensor data is playing an increasing role as a basis for modeling, diagnostics, decision making and predictive maintenance, there are currently no standard software tools available for data analytics and machine learning where effective use is made of the physical interconnection structure of the constituting subsystems. The results of the ERC Advanced Research project “Data-driven modeling in dynamic networks” (2016-2022) will be translated into an effective general purpose GUI supported MATLAB-based toolbox for data analytics, including data-driven dynamic modelling and diagnostics, for the situation of spatially interconnected linear dynamic systems. The scientific methods and algorithms will be turned into into effective workflows to be used by engineers, researchers and students for applications in a variety of engineering domains. A professional software architecture and first steps of an implementation have already been realized. The project will be guided by stakeholders from industry, among which MathWorks Inc, ASML and ABB, who will also be involved in the development of use cases. Parallel to this project, the research into effective methods will continue, allowing to overcome shortcomings in the current tools that might appear. A further plan for exploitation of the toolbox will be made by the end of the project, and will be dependent on the proof-of-concept evaluation.

Keywords: software,matlab,dynamic networks,system identification,data driven modeling,machine learning,systems theory,diagnostics
Responsive Law for Global Value Chains (CHAINLAW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

CHAINLAW will develop a novel conceptual and normative legal language for Global Value Chains (GVCs). GVCs are the interconnected trade structures that underlie the production of commodities and offering of services. While GVCs have been intensively theorised in the social sciences, they are largely unknown as legal categories. This is highly problematic when the law is starting to legislate or decide cases about supply-chain responsibility. The core aim of CHAINLAW is to provide the concepts necessary for law to be able to develop appropriate and effective legislation for GVCs and appropriate approaches to supply-chain liability. It will do so by a combination of theoretical, doctrinal, empirical, technical, and normative analysis on the law of GVCs. To that end, CHAINLAW is ground-breaking by employing, first, a novel theoretical framework based on institutional theory that that sets up a threefold typology of GVCs allowing their qualifications as part of the company, contracts, and as a network simultaneously. CHAINLAW engages, secondly, in a multi-disciplinary descriptive analysis that traces this institutional understanding within various regulatory layers that govern GVCs that include formal law, private and technological regulation in GVCs. It proposes an analysis of the law on GVCs that integrates (i) legal doctrinal analysis of company and contract law and the legal debate on networks, (ii) socio-legal research on private regulatory documents that are set up by companies, contracting parties and within the GVC network, and (iii) socio-technical analysis of supply-chain technologies, as used by companies, commercial parties, and in networked processes. Third, CHAINLAW uses these insights to develop a strategy for how the law can responsively govern GVCs, in private law including liability and public law intervention. Such responsive law needs to integrate the different institutional dimensions of GVCs and address the various regulatory layers in GVCs.

Keywords: global supply chains,legal sociology,globalization and law,legal pluralism,institutions of private law
Chiral separation of molecules enabled by enantioselective optical forces in integrated nanophotonic circuits (CHIRALFORCE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Netherlands,United Kingdom,Italy,Estonia
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 3263726.25
EU funding (EUR): 3263726.25
Participants: 8
Project status: SIGNED

Separating enantiomers is crucial to produce bio-active molecules, e.g., in early-phase drug discovery. CHIRALFORCE aims at a radically new strategy to separate enantiometers on chip, using chiral optical forces at silicon-based integrated waveguides. The present solution of chiral chromatography for this multi-billion market is slow and cumbersome since it requires tailored chemistry for each chiral compound, and relies on large and expensive separation columns. Instead, CHIRALFORCE envisions cm-length optical circuits integrated with microfluidics for extremely quick, tuneable, and cheap enantiomeric separation. The underlying mechanism relies on optical forces that are enantioselective, due to interaction of spin-properties of the optical field with the chiral optical polarizability of matter. These chiral optical forces can be tailored well beyond the possibilities of free-space chiral light through nanophotonic design of strongly confined modes. Flowing analyte in microfluidic channels along cm-length laser-driven will then result in enantio-separation. The approach to reach our main objectives relies on three main consortium strengths. First, we will design and synthesize chiral molecules and nanoparticles that will allow us to explore chiral forces regardless of how the chiral polarizability of matter is tuned by the size, shape, and in-built spectroscopic resonances, Next, we will establish the general framework of chiral optical forces on nanoparticles and molecules in liquid environments, leveraging our strength in nanophotonic theory, design and experiment, on chiral/spin-properties of electromagnetic fields. Finally, we will leverage our experience in nanotechnology to fabricate silicon-based photonic integrated circuits integrated with microfluidics to demonstrate enantiomer separation.

Keywords: enantiomer separation photonic integrated circuits chirality optical forces chromatography microfluidics
Female Slavery in Mediterranean Catholic Europe, 1500-1800 (FemSMed)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2488125.0
EU funding (EUR): 2488125.0
Participants: 1
Project status: SIGNED

More than one million, and perhaps as many as two million individuals were enslaved in the Catholic regions of the early modern Mediterranean. Despite evidence of the prevalence of female slavery and of the fact that women constituted the bulk of the enslaved population in some areas, scholarship on bondage in Mediterranean Europe from 1500 to 1800 retains a strong androcentric bias. Transcending national historiographic traditions, FemSMed will break new ground by providing, for the first time, a comprehensive investigation of women’s enslavement and its wide-ranging implications during the pivotal period in European history that encompassed the Renaissance, the Reformations, the onset of European colonialism, the Scientific Revolution, and the Enlightenment. Whereas extant scholarship emphasizes religious, political, and economic aspects, FemSMed’s goal is to uncover the sexual, familial, and broader social contexts of these aspects. By elucidating the long-term consequences of women’s enslavement, it further aims to reveal the gendered mechanisms of racialization and ethnicization, and raise awareness of Europe’s multiethnic and multireligious heritage. This will be done by exploring 1) typologies of slave women’s abuse and their implications for perceptions of illicit sexuality and gender-based violence; 2) how the birth of children under slavery bore on the creation of categories of difference; 3) the impact of domestic female slavery on slaveholders’ family life and on conceptualizations of consanguineal and affinal kinship; 4) how the enslavement of minority women shaped collective identities and intercommunal relations. Informed by theoretical advances in the sociological and anthropological study of slavery, FemSMed employs methodologies from social and religious history as well as from art history and the study of material culture, combining a transcultural approach with a gender analysis of a vast array of archival, printed, visual, and material sources.

Keywords: female slavery interreligious encounters in the mediterranean forced baptisms in the early modern era refugees in the age of reformations