Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Origin: reconstructing African prehistory using ancient DNA (ORIGIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Human history in Africa over the last tens of thousands of years is an integral part of understanding the origins of our species. The starting point for most genetic studies of human origins has been based on the depth of present-day human diversity between and within African populations. Even though aDNA studies provided additional resolution and transformed our understanding of the past demography of different human groups reaching as far as ~430ka in Europe, due to the challenging conditions for endogenous DNA preservation, relatively few ancient genomes have been recovered from Africa compared to Europe and Asia, limiting our insights into the population history of the African continent. This project aims to fill-in this gap by making use of the recent advancements in aDNA methodology and generate genome-wide data from a larger number of ancient African individuals across the continent and dating as far back as the Later Stone Age, i.e. to at least ~20ka. These ancient genomes will be analysed together with the published present-day and ancient modern human, as well as archaic datasets in order to investigate migrations, level of interactions, admixture and population structure of different human groups within Africa, as well as between Africa and other parts of the world.

Keywords: ancient dna,african prehistory,population genetics
Multimegawatt high-temperature electrolyser to generate green hydrogen for production of high-quality biofuels (MultiPLHY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Finland,France,France,Netherlands,Luxembourg
Call: Multi megawatt high-temperature electrolyser for valorisation as energy vector in energy intensive industry (H2020-JTI-FCH-2019-1, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 9751722.5
EU funding (EUR): 6993725.39
Participants: 9
Project status: SIGNED

The shift to a low-carbon EU economy raises the challenge of integrating renewable energy (RES) and cutting the CO2 emissions of energy intensive industries (EII). In this context, hydrogen produced from RES will contribute to decarbonize those industries, as feedstock/fuel/energy storage. MULTIPLHY thus aims to install, integrate and operate the world’s first high-temperature electrolyser (HTE) system in multi-megawatt-scale (~2.4 MW), at a chemical refinery in Salzbergen (DE) to produce hydrogen (≥ 60 kg/h) for the refinery’s processes. MULTIPLHY offers the unique opportunity to demonstrate the technological and industrial leadership of the EU in Solid Oxide Electrolyser Cell (SOEC) technology. With its rated electrical connection of ~3.5 MWel,AC,BOL, electrical rated nominal power of ~2.6 MWel,AC and a hydrogen production rate ≥ 670 Nm³/h, this HTE will cover ~40 % of the current average hydrogen demand of the chemical refinery. This leads to GHG emission reductions of ~8,000 tonnes during the planned minimum HTE operation time (16,000 h). MULTIPLHY’s electrical efficiency (85 %el,LHV) will be at least 20 % higher than efficiencies of low temperature electrolysers, enabling the cutting of operational costs and the reduction of the connected load at the refinery and hence the impact on the local power grid. A multidisciplinary consortium gathers NESTE (a Green Refiner as end-user), ENGIE (a global energy system integrator & operator), PaulWurth (Engineering Procurement Construction company for hydrogen processing units), Sunfire (HTE technology provider) and the world-class RTO CEA. They focus on operation under realistic conditions and market frameworks to enable the commercialisation of the HTE technology. By demonstrating reliable system operation with a proven availability of ≥ 98 %, complemented by a benchmark study for stacks in the 10 kW range, critical questions regarding durability, robustness, degradation as well as service and maintenance are addressed

Keywords: renewable energy sources res,ghg emission reductions,hydrogen production,high temperature electrolyser hte,solid oxide electrolysis cell soec,multi megawatt scale,energy intensive industry
Opening new markets for Single Quantum Photodetectors (SQP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-04-01
End date: 2021-09-30
Duration (months): 30.0
Total project cost (EUR): 2831250.0
EU funding (EUR): 1981875.0
Participants: 1
Project status: CLOSED

Scientific experiments and medical diagnostics rely heavily on optical measurements. Live imaging with high detection efficiency, high time resolution and low noise level will disrupt existing imaging technologies. Current technologies cannot meet these challenges as light detectors suffers from poor performances. Single Quantum pioneered a ground-breaking new technology based on detecting single photons with superconducting nanowires, combining the world’s highest detection efficiency with time resolution and noise performances without any compromises. We already sold 70 systems to universities and research institutes. This project has been developed to enhance this system for the larger industrial domain, focusing initially on bioimaging. The scientific bioimaging market is worth €500m/year and a market share of 35% is anticipated. Due to our current strong position here, Single Quantum will be the main supplier of single photon detectors. We will use this position as a mean for entering the larger market of clinical diagnostics imaging. The clinical diagnostics imaging market for Single Quantum is worth €4,070m/year with an expected market share of 10%. Our strategy is to validate our technology with bioimaging scientists for application of our detectors in diagnostic or therapeutic technologies. Our strategy to deal with direct and indirect competition is to approach OEM imaging systems manufacturers and offer them the opportunity to use our detection units in their systems. Single Quantum has the dream team in place to upscale this revolutionary technology with the best available minds in the field of single photon detectors, and decades of experience in developing and commercialising high-tech products. We grew the team from 3 to 24 in six years’ time. Seven employees hold a PhD in Physics. In this project a limited investment in the adaptation of the product will be performed to address the specific needs specified by the User Group.

Keywords: sensitive imaging,bioimaging,microscope,single photon detector,light detector
Monoamine oxidase B inhibitors as novel drugs targeting NLRP3 inflammasome (MOBILISE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-06-30
Duration (months): 22.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Although the number of anti-inflammatory drugs has increased during the past decade, there is still an urgent need to develop novel alternatives that overcome limitations of current treatments. The most used therapies, such as non-steroidal anti-inflammatory drugs, non-analgesic anti-inflammatory drugs or colchicine, often present severe side-effects. In addition, in recent years biologicals have appeared, but they are extremely expensive. Therefore, novel therapeutic approaches with lower toxicity, higher tolerance and lower price must be developed to treat autoinflammatory and autoimmune diseases. Since the NLRP3 inflammasome is a key contributor of inflammatory diseases (including gout, pseudogout, metabolic arthropathies and multiple sclerosis), its targeting has become very relevant for the development of novel therapeutics. As part of our ERC project STePS, we discovered a novel activation pathway to the NLRP3 inflammasome, which opens new opportunities to use an existing line of compounds for radically new medical indications. Within STePS, we uncovered the activation of the NLRP3 inflammasome by the enzyme Monoamine Oxidase B (MAO-B) through ROS production, positioning MAO-B as a promising target to treat autoinflammatory and autoimmune diseases. Given that there are several MAO-B inhibitors (iMAO-B) currently used in the clinic for treatment against Parkinson disease, the use of iMAO-B represent a major opportunity to develop new therapies at low risk and a fraction of the cost. This ERC PoC MOBILISE will assess the technical and commercial feasibility of repositioning iMAO-B as a novel treatment of gout and other NLRP3 inflammasome-driven diseases. Within MOBILISE, we aim to explore the efficacy in vivo of iMAO-B, solidify our IP protection, perform an extensive market and competitor analysis and develop a detail business plan to define the optimal commercialisation route for MAO-B inhibitors in gout and other autoinflammatory diseases.

Keywords: monoamine oxidase inhibitors,nlrp3 inflammasome,autoimmune diseases,autoinflammatory diseases,gout
Mainstreaming of refinancing schemes as enhancer for the implementation of energy efficiency service projects (REFINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Spain,Ukraine,Spain,Ireland,Austria,Greece,Croatia,Slovenia,Czechia,Netherlands
Call: Mainstreaming energy efficiency finance (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-06-01
End date: 2023-05-31
Duration (months): 36.0
Total project cost (EUR): 1745697.5
EU funding (EUR): 1745697.5
Participants: 11
Project status: SIGNED

The ultimate goal of the REFINE-project is to contribute to the supply of sufficient and attractive financing sources to energy efficiency investments through enhancement of refinancing schemes which are understood as important amplifier for market growth. Refinancing is an approach where an EES provider sells and a refinancing institution acquires receivables to be paid by an EES client. The project activities focus on the enhancement of refinanceability of energy efficiency projects, consisting of the following elements: Ensuring admissibility of refinancing schemes for energy efficiency projects; reducing transaction cost of refinancing schemes through standardisation; and facilitating risk assessment through increased transparency and use of credit guarantees. Based on the assessment of existing good practice examples, generic refinancing schemes are derived and supporting tools are developed, such as standardised contract stipulations and a rating system. The enlarged use of refinancing schemes in the energy efficiency business is stimulated by awareness raising among all relevant target groups and by capacity building improving know-how on practical implementation of refinancing schemes. The consortium covers 11 countries focussing on South and Eastern Europe since energy efficiency projects in these countries suffer most from financing barriers. The project applies a collaborative approach to all its project activities bringing together financial institutions, EES providers and facilitators.

Keywords: refinancing scheme,refinancing,refinancing instrument,esco,energy efficiency service,energy efficiency service company,guarantee instrument,rating
Photonic enabled Petascale in-memory computing with Femtojoule energy consumption (PHOENICS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Switzerland,Belgium,Switzerland,United Kingdom,United Kingdom
Call: Neuromorphic computing technologies (H2020-FETPROACT-2020-01, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 5883191.25
EU funding (EUR): 5883191.25
Participants: 10
Project status: SIGNED

Modern societies and economies increasingly depend on the massive generation of data resulting from the exponential growth of internet applications. Drastically enhanced computational performance is in particular needed for a plethora of applications in artificial intelligence (AI) which necessitate unprecedented processing power, memory and communication bandwidth. This demand cannot be met by modern digital electronic technologies that are rapidly approaching their physical limits. The PHOENICS consortium will break through these barriers and lay the foundation for a disruptive neuromorphic compute platform based on hybrid photonic integrated circuits. By providing access to parallelized neuromorphic processing using wavelength division multiplexing, the PHOENICS consortium will harness exceptional scaling potential not available to electronic systems and will deliver multiply-accumulate (MAC) performance at 3.2 PetaMAC/s at an energy cost of 50 FemtoJoule/MAC. Building on a hybrid architecture with substantial potential for future upscaling, the PHOENICS project aims at implementing a disruptive architecture which outperforms state-of-the-art electronic neuromorphic hardware. The consortium partners have shown the significant technological potential that a photonic approach can offer by establishing a new brain-inspired computing paradigm using phase-change-materials. By implementing scalable systems based on foundry processing for creating bio-mimicking material platforms, the PHOENICS consortium will provide a new generation of photonic hardware accelerators for neuromorphic processing and develop a strong ecosystem for photonic computing. The PHOENICS technology will thereby directly impact today’s technology and likewise address future needs for high bandwidth and low latency compute systems for AI.

Keywords: coherent frequency combs,phase change materials,hybid nanophotonics
Cloud-cloud interaction in convective precipitation (INTERACTION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany,Denmark
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-07-01
End date: 2024-04-30
Duration (months): 70.0
Total project cost (EUR): 1314800.0
EU funding (EUR): 1073577.01
Participants: 2
Project status: SIGNED

State-of-the-art simulations and observations highlight the self-organization of convective clouds. Our recent work shows two aspects: these clouds are capable of unexpected increase in extreme precipitation when temperature rises; interactions between clouds produce the extremes. As clouds interact, they organize in space and carry a memory of past interaction and precipitation events. This evidence reveals a severe shortcoming of the conventional separation into "forcing" and "feedback" in climate model parameterizations, namely that the "feedback" develops a dynamics of its own, thus driving the extremes. The major scientific challenge tackled in INTERACTION is to make a ground-breaking departure from the established paradigm of "quasi-equilibrium" and instantaneous convective adjustment, traditionally used for parameterization of "sub-grid-scale processes" in general circulation models. To capture convective self-organization and extremes, the out-of-equilibrium cloud field must be described. In INTERACTION, I will produce a conceptual model for the out-of-equilibrium system of interacting clouds. Once triggered, clouds precipitate on a short timescale, but then relax in a "recovery" state where further precipitation is suppressed. Interaction with the surroundings occurs through cold pool outflow,facilitating the onset of new events in the wake. I will perform tailored numerical experiments using cutting-edge large-eddy simulations and very-high-resolution observational analysis to determine the effective interactions in the cloud system. Going beyond traditional forcing-and-feedback descriptions, I emphasize gradual self-organization with explicit temperature dependence. The list of key variables of atmospheric water vapor, temperature and precipitation must therefore be amended by variables describing organization. Capturing the self-organization of convection is essential for understanding of the risk of precipitation extremes today and in a future climate.

Keywords: precipitation extremes,clausius clapeyron relation,atmospheric convection,self organization
Ageing Multiphysics of Asphalt Materials (AMAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-21
End date: 2019-09-20
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The ultimate objective of this fellowship, entitled “Ageing Multiphysics of Asphalt Materials (AMAM)”, is to intensively train a talented researcher, Dr Fan Gu, through an interdisciplinary project focused on the modelling of the ageing multiphysics and performance evaluation of asphalt materials. Deliverables including fundamental understanding of asphalt ageing multiphysics, novel anti-ageing materials and a systematic performance prediction framework for engineering applications in sustainable design, construction, and maintenance of road infrastructures. The Fellow will receive intensive technical training in multidisciplinary field of chemistry (Aston), material science (Aston), computational modelling (Aston, TUD), experimental characterisation (NTEC) and industry applications (Nynas and AI). The Fellow will also receive inter-sector professional skills training in project management, organization and networking. The project outputs will enhance the EU scientific excellence by exploring the ageing mechanisms of complex bitumen-based materials, strength the EU industry leadership in anti-ageing material innovation, and protect EU environment and natural resources through extended service life of the aged road infrastructures using innovated recycled/bio-based anti-ageing construction materials. Uniquely, the project will enable the Fellow to an independent leading researcher in infrastructure engineering for his academic career and to become a rare asset to European research through leading the research and building effective collaboration network among academia and industry.

Keywords: construction materials,road infrastructures,asphalt ageing
Passive seismic techniques for environmentally friendly and cost efficient mineral exploration (PACIFIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,South Africa,Finland,Sweden,France,France,Canada,United Kingdom
Call: New solutions for sustainable production of raw materials (H2020-SC5-2017-OneStageB, 2017)
Start date: 2018-06-01
End date: 2021-11-30
Duration (months): 42.0
Total project cost (EUR): 3320691.0
EU funding (EUR): 3200066.0
Participants: 15
Project status: CLOSED

The PACIFIC consortium will develop a new, low-cost and environmentally friendly tool for exploring for mineral deposits beneath the surface. The approach will build on the "traditional" passive seismic method, which is capable of providing useful broad-brush background information about the geological and structural setting of mineralised regions, but lacks the resolution needed for reliable identification of ore bodies. Two radically new developments are planned; reflection passive seismics, which is appropriate from greenfields exploration, and the multi-array method, which will typically be deployed during drilling or in brownfields exploration. Both techniques have major advantages over current techniques, namely relatively low cost and minor impact on the environment. Through the participation of two mineral exploration companies in the project, the two techniques will be validated on test sites in Canada and Sweden, thus brought from TRL2 to TRL5. Research on social acceptance and public perception of risk for mining activities will accompany the deployment and testing of the techniques. The PACIFIC consortium comprises a major university and a research institute who will develop the theoretical background and codes for data treatment, a mid-tier mining company and a junior exploration company who will provide logistic support and access to test sites, two small service companies who will conduct the surveys and analyse the data, a geological survey who will conduct research on public opinion, and a company who will manage the project. The PACIFIC project will thereby transfer the fruits of cutting-edge scientific research to industry and launch the development and deployment of new mineral exploration methods. This will enhance the competitiveness of the European mineral exploration industry, contribute to the discovery of new European ore deposits and decrease the dependence of European industry on imported mineral products.

Keywords: mineral exploration,passive seismic techniques,high resolution subsurface imaging,innovative data coding,low environmental impact,low cost