Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Personalised nutrition of low-birth-weight infants (Preemie)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-10-01
End date: 2022-04-30
Duration (months): 31.0
Total project cost (EUR): 2377937.5
EU funding (EUR): 1664556.0
Participants: 1
Project status: CLOSED

Each year 500,000 preterm babies are born in Europe out of 15-million worldwide. They often have poor health, with a severe lifetime impact on their quality of life and that of their families. Pre-term birth is a leading cause of lifelong disabilities with high societal economic costs. Inadequate nutrition is the major reason for preterm infants’ ill health. To grow as they would in utero, preterm infants need more nutrition than is provided by their mother’s milk, so the milk needs to be fortified to avoid undernourishment. However, the fortification typically done in Neonatal Intensive Care Units (NICUs) does not take into account the individual differences in the human milk’s composition and the infant’s nutritional needs, which vary with age and weight. To address this issue, Tellspec has developed Preemie, the first rapid, portable, affordable, and easy-to-use milk testing system calibrated with human milk, that automatically calculates the fortification needed, to reduce the workload and human errors. Preemie also uses blockchain technology to trace the origin and confirm the authenticity of the donor’s milk. An inexpensive portable and rapid analyser such as Preemie would disrupt the existing market by allowing NICUs and milk banks to scan all donor milk and automatically suggest fortification to be done based on each infant's individual needs, resulting in optimal health. In this project Tellspec will commercialise Preemie, by tailoring the software to the market and validate it in collaboration with a European hospital and a milk bank, by obtaining the medical certification needed to go to market, and by implementing advertising, sales promotions and marketing activities. The funds raised will enable Tellspec to enlarge its customer base, expand the current team of people, set up high-volume distribution capacity in Europe, and consolidate the business strategy to pave the way for future VC investments.

Keywords: pre term health,neonatal intensive care units,human milk banks,human milk composition,blockchain technology,artificial intelligence,learning algorithms,pre term birth,human milk analyser
Moment-based nonlinear energy-maximising optimal control of wave energy systems to secure a renewable future (DESTINY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

Ocean wave energy is a massive and untapped resource, which can make a valuable contribution towards a sustainable, global, energy mix. Despite the fact that ocean waves are a vast resource, wave energy converters (WECs) have yet to make significant progress towards commercialisation. A fundamental stepping stone to achieve this objective is the availability of appropriate optimal control technology, such that energy conversion is performed as economically as possible, minimising the delivered energy cost, and operating across a wide range of ocean conditions. This project will greatly advance WEC control technology by providing a novel and reliable nonlinear optimal control framework for WECs, based on the mathematical concept of moments. Such a framework will feature an accurate nonlinear description of the physics associated with the wave energy extraction process, optimally maximising energy absorption for single devices and array configurations, and exhibiting real-time capabilities. This will provide all stakeholders in the ocean engineering and wave energy fields with a fundamental and easily-accessible tool to facilitate reaching economic viability of wave energy technology. This project is comprised of 4 scientific work packages, which accomplish: (1) generalisation of the control framework for a large class of nonlinear control- and wave-dependent effects, (2) experimental validation of the control strategy, (3) extension to WEC arrays, and (4) release of an open-source software. In addition, this fellowship will expand the career horizons of the fellow through a highly multidisciplinary plan, building upon and extending beyond his current competencies. The fellow is well-positioned to undertake this project, allowing him to fully develop innovative concepts from his PhD research. This fellowship will provide the fellow with an unparalleled opportunity to grow as a scientist and engineer, launching him on a trajectory to a productive scientific career.

Keywords: wave energy,ocean engineering,nonlinear control,optimal control,moment matching
Transcriptomic m1A - a new key player in the epitranscriptome arena (m1ARNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-07-01
End date: 2022-06-30
Duration (months): 60.0
Total project cost (EUR): 2457500.0
EU funding (EUR): 2457500.0
Participants: 1
Project status: CLOSED

Reversible epigenetic modifications regulate gene expression to define cell fate and response to environmental stimuli. Gene expression tuning by DNA and chromatin modifications is well studied, yet the effect of RNA modifications on gene expression is only starting to be revealed. More than a hundred chemical modifications decorate RNAs, mainly non-coding ones, expanding their nucleotide vocabulary and mediating their diverse functions. Several modifications were globally mapped in mRNA. Only two, N6-methyladenosine (m6A) and N1-methyladenosine (m1A) exhibit a distinct topology alluding to a functional role. We pioneered the identification of m6A that is located preferentially in distinct transcript landmarks, mostly around stop codons and mediates transcript localization, splicing, decay and translation. We now identified m1A which decorates thousands of genes mainly in the start codon vicinity, upstream to the first splice site. Our preliminary results indicate that m1A dynamically responds to environmental stimuli and plays a central role in translation regulation. The regulation and functions of m1A are still terra incognita. Our objectives are to identify m1A writers and erasers, elucidate m1A readers and the mechanisms whereby m1A dictates downstream outcomes, particularly translation regulation. We will study m1A functions in response to physiologic stimuli and stress conditions in cells and animal models by manipulation of the m1A deposition machinery. As epigenetic marks operate in a context-dependent concerted way we will map m1A marks concomitantly with m6A to decipher their interplay in regulating gene expression via a putative “epigenetic RNA code”. The data obtained from parallel mapping of m1A and m6A at a single nucleotide and a single transcript resolution, will expose the interplay between these two mRNA modifications in the context of multilayer epigenetics. The study of m1A circuits may identify targets amenable to therapeutic manipulations.

Keywords: n1 methyladenosine,translation regulation
Resolving conflicts between food security and biodiversity conservation under uncertainty (ConFooBio)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1497151.0
EU funding (EUR): 1497151.0
Participants: 1
Project status: CLOSED

Resolving conflicts between food security and biodiversity conservation under uncertainty Conflicts between food security and biodiversity conservation are increasing in scale and intensity and have been shown to be damaging for both biodiversity and human livelihoods. Uncertainty, for example from climate change, decreases food security, puts further pressure on biodiversity and exacerbates conflicts. I propose to develop a novel model that predicts solutions to conflicts between biodiversity conservation and food security under uncertainty. ConFooBio will integrate game theory and social-ecological modelling to develop new theory to resolve conservation conflicts. ConFooBio will implement a three-tiered approach 1) characterise and analyse 7 real-world conservation conflicts impacted by uncertainty; 2) develop new game theory that explicitly incorporates uncertainty; and 3) produce and test a flexible social-ecological model, applicable to any real-world conflict where stakeholders operate under conditions of extreme uncertainty. The project has importance for society at large because ecosystems and their services are central to human wellbeing. Managing a specific natural resource often results in conflict between those stakeholders focussing on improving food security and those focussed on biodiversity conversation. ConFooBio will illuminate resolutions to such conflicts by showing how to achieve win-win scenarios that protect biodiversity and secure livelihoods. In this project, I will develop a practical, transparent and flexible model for the sustainable future of natural resources that is also robust to uncertainty (e.g., climate change); this model will be highly relevant for environmental negotiations among stakeholders with competing objectives, e.g., the negotiations to set the United Nations Sustainable Development Goals in September 2015.

Keywords: social ecological systems modelling,decision making,game theory,behavioural games
Research empowerment on solute carriers (ReSOLUTE) (ReSOLUTE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Italy,Switzerland,Switzerland,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Unlocking the Solute Carrier Gene-Family for Effective New Therapies (Unlock SLCs) (H2020-JTI-IMI2-2016-10-two-stage, 2016)
Start date: 2018-07-01
End date: 2023-12-31
Duration (months): 66.0
Total project cost (EUR): 24140172.0
EU funding (EUR): 12000000.0
Participants: 14
Project status: SIGNED

The Research empowerment on solute carriers (ReSOLUTE) proposal aims at inducing a decisive acceleration in the intensity of SLC research worldwide while establishing solute carriers (SLCs) as a tractable target class. It is composed of a core consortium of seven academic/SME members (CeMM, Univ. of Oxford, Univ. of Manchester, AXXAM Spa, Univ. Leiden, Max-Planck Institut für medizinische Forschung, Univ. Wien) and six industrial partners (Pfizer Limited UK, Novartis Pharma AG, Boehringer-Ingelheim, Vifor Pharma Group, Sanofi Aventis Recherche et Développement, Bayer AG) with established and complementary expertise combining industry grade standards and systems level principle-driven analysis. ReSOLUTE merges systematic and focused approaches: 1) the generation of reliable and validated ‘hardware’ such as cell lines, proteins, antibodies/high affinity binders and large ‘omics’ datasets, 2) a central deorphanisation process coupling genomic engineering to metabolomics and supported by genetic and proteomics studies, 3) a non-redundant process to test systematically the suitability of a certain SLC to a variety of assay formats, 4) a collection of interlinked networks that cover different expertise, datasets and functional connections among SLCs, integrated into large-scale data repositories and a dedicated knowledgebase. The ReSOLUTE strategy will be applied in parallel at the super-family level and, in a more in-depth manner, to a prioritized gene list elected to be potential drug targets. To implement this and achieve the expected goals, the consortium is supported by a large network of academic and industrial partners with specific knowledge of certain SLCs and tools, willing to be accessed at any time and provide specific expertise. Together with a strong dissemination and exploitation plan, we therefore expect that ReSOLUTE will transform the landscape of SLC research for years to come.

Keywords: solute carriers,metabolomics,deorphanisation,assay development,genomic engineering,proteomics,genetic interactions,knowledgebase,networks,structural biology,drug targets,transporters
Crosstalk between nuclear envelope and DNA Damage Response: Role of nucleoporin TPR in the maintenance of genomic integrity (ENVERESP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Each cell in the human body receives thousands of DNA lesions per day. To counteract threats posed by DNA damage, cells have evolved an integrated signaling network called the DNA-damage response (DDR). This mechanism allows cells to detect DNA lesions, signal their presence and promote their repair. Mutation of DDR genes, which serves as a biological barrier against tumor progression, leads to cancer development2. A large-scale proteomic analysis of proteins phosphorylated in response to DNA damage by checkpoint kinases ATM and ATR identified extensive protein networks responsive to DNA damage. Interestingly, among the proteins identified to be phosphorylated upon DNA damage were several nuclear pore complex factors including nucleoporin Translocated Promoter Region (TPR)5. TPR was previously linked to cancer since its N-terminal domain has been found fused with the protein kinase domains of various proto-oncogenes such as RAF and MET resulting in human solid tumors. TPR expression level was found deregulated in many types of human tumors such as breast and liver cancer8. Amplification of TPR was also significantly associated with a shorter survival of patients with pediatric intracranial ependymomas9. All these findings support a critical role for TPR in the mechanism of oncogenesis. By employing state-of-the-art proteomics (SILAC), genetics (in vitro mutagenesis), genomics (DNA binding profiling) and imaging (electron microscopy) technologies we will investigate how TPR prevents tumor genesis via its role in the DDR network coordinating DNA repair, DNA replication and chromatin condensation with the nuclear envelope upon DNA damage. Providing mechanistic insight into the role of TPR in DDR and the maintenance of genome stability will not only contribute to our understanding of molecular principles of response to damaged DNA, but will allow us to optimize existing cancer treatments and design new molecular targeted therapies in the future.

Keywords: atr pathway,cancer,cell cycle checkpoint,dna damage response,dna repair,genomic instability,nuclear envelope,tumorigenesis
Advances in the Diagnosis and Gene Therapy of Congenital dyserythropoietic Anemia (ADGENTHE-CDA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-16
End date: 2023-03-15
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

The emergence of next-generation sequencing technology (NGS) has revolutionized the diagnosis of genetic diseases including hereditary haematological diseases (HHD) providing a fast and accurate diagnosis, which ultimately leads to health improvement in these patients, as effective treatments are earlier provided, avoiding unwanted and detrimental aspects such as iron toxicity. Gene therapy is starting to be successfully applied in HHD. BloodGenetics (BG) S.L. has previously identified new mutations and new causative genes of HHD and nowadays is commercializing NGS-panels for a number of HHD. This proposal will focus in a particular HHD, the Congenital dyserithropoietic anemias (CDA), a bone marrow failure condition characterized by congenital anemia with ineffective erythropoiesis. The general aim of this proposal is to advance in the establishment of state-of-the-art tools for the diagnosis and treatment of CDA. Specifically, we aim to: 1) stablish a new panel including novel identified genes for and improvemnent in CDA diagnosis, 2) develop new engineered cellular models using CRISPR/CAS9 system for CDA modelling and 3) develop gene therapy tools applied to type II CDA in collaboration with International University of Catalunya (UIC) and Center for Energy, Environmental and Technological Research (CIEMAT). We strongly believe that this project will result in the achieving of a faster and more accurate diagnosis of CDA and to advance in the establishment of molecular tools for CDA gene therapy, which overall will dramatically improve patients’ quality of life.

Keywords: hereditary hematological diseases,anemia,congenital dyserytropoietic anemia,next generation sequencing,genetic diagnosis,gene theraphy
Transforming applicability of density functional theory simulations (newDFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-15
End date: 2023-10-14
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Quantum-chemical simulations have become an integral part of chemistry research, enabling significant technological advances in predictions of new drugs, solar cells, catalysts, battery materials. The present project seeks to overcome a fundamental hurdle that precludes quantum-chemical simulations from having high accuracy across chemistry; that is the daunting problem of strong electronic correlations. Strong correlations play a crucial role in chemistry, as they dictate reactivity principles and define properties of transition-metal compounds (workhorses of catalysis) and technologically relevant materials. Specifically, the present project seeks to translate the researcher's new framework for the development of the next-generation of density functional theory (DFT) methods into computer codes. This new framework is inspired by the exact theory of strong electronic correlations and fully departs from the mainstream strategy for the construction of DFT approximations ("Jacob’s ladder of DFT"). The DFT methods developed in this project will be used to simulate chemical systems that are beyond the reach of state-of-the-art DFT. These include bond dissociations, transition metal catalysts (e.g., novel catalysts used in the conversion of the carbon-dioxide into small alcohols), radical species, platonic hydrocarbon cages. The researcher is a chemist that focuses on the development of quantum-chemical theories, and the host is a leader in leader in the development of electronic structure codes used in nanoscience, material science, and chemistry. In this project, the expertise of the researcher and of the host will be put together to transform the initial success of the researcher's framework into a fundamentally novel (conceptual and computational) approach that can accurately simulate a range of strongly correlated chemical systems and processes that are inaccessible to state-of-the-art quantum-chemical simulations.

Keywords: density functional theory,strong correlation,transition metals
Demonstrable and replicable cluster implementing systemic solutions through multilevel circular value chains for eco-efficient valorization of fishing and fish industries side-streams (EcoeFISHent)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Innovation actions
Countries involved: Italy,Italy,Israel,Italy,Italy,Italy,Spain,Italy,Italy,Italy,Italy,Italy,Spain,Norway,Belgium,Bulgaria,France,Kenya
Call: Demonstration of systemic solutions for the territorial deployment of the circular economy (H2020-LC-GD-2020-3, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 18564214.47
EU funding (EUR): 15145267.12
Participants: 39
Project status: SIGNED

EcoeFISHent demonstrates a replicable systemic and sustainable cluster for territorial deployment of the climate-neutral circular economy by creating six multilevel and synergic circular value chains (CVC) interconnecting blue- and green-economies to reconcile human industrial and economic activities with marine ecosystems and marine protected areas. The EcoeFISHent innovative bio-mass pre-treatment and extraction technologies will enable sustainable and efficient exploitation of fish processing side-streams (FPS) by obtaining bio-actives and galantine for high value-added food supplements and skin care products, biodegradable and compostable barrier layer for food packaging. Other fishing- and fish-industry side-streams (FFS) will undergo the Black Soldier Fly bioconversion to yield innovative soil fertilizer, oil for biodiesel and chitin for cosmetic applications. End of life fishing nets from aquaculture and fisheries will be recycled and converted into automotive polymer-based components and into packaging for cosmetic products. The multilevel interconnected cluster will be managed by a cloud-based platform communicating with physical IoT systems enabling safe and efficient operation of the logistic and transport infrastructure. The cluster busines model and the cluster digital twin will allow simulating critical and optimal scenarios for quantitative analysis of cluster performance measured by dedicated KPIs, also enabling the assessment of the cluster replicability in other geographic areas and fostering investments pipelines. Community and stakeholder?s involvement will be promoted also in the implementation of specific actions for marine ecosystem preservation by modeling, application of better practices and technologies for strongly reducing by-catch and for stopping ghost gears. Social and justice inclusion programs will be implemented by employing disadvantaged individuals, to increase overall cluster employment and to apply distributive justice criteria

Keywords: side streams,sustainable exploitation of resources,ecosystem,circular value chains,food,cosmetics,packaging,nutraceuticals,automotive