Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mitochondrial Cristae Biogenesis (MitoCRISTAE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2286248.0
EU funding (EUR): 1170655.16
Participants: 2
Project status: SIGNED

Mitochondrial cristae biogenesis is an enigma ever since the first imaging of mitochondria, the ‘powerhouses’ of eukaryotic cells, by electron microscopy in the 1950s. The mitochondrial cristae, dynamic and structurally conserved invaginations of the mitochondrial inner membrane, are essential for respiratory ATP generation. Thereby, the form and function of the mitochondrial inner membrane are deeply intertwined. Indeed, irregular or disturbed cristae morphologies are believed to cause numerous human diseases, including neurodegeneration, cardiomyopathies, metabolic disorders and cancer. Previous approaches to study cristae biogenesis have relied primarily on the use of 2D electron microscopy and biochemistry to analyse mutant cells defective in cristae formation. Based on striking pilot experiments, we propose to study cristae biogenesis by a radically different approach. We will induce synchronous cristae development in gene-edited cell lines initially defective in cristae formation. We will then follow de novo cristae biogenesis over time by combining a series of enabling approaches, including live cell and MINFLUX super-resolution microscopy, 3D (cryo) electron microscopy, label-free (SWATH) mass spectrometry, and single molecule counting. These technologies have just emerged in the last few years, and thus this proposal would not have been possible a few years ago. The primary aim of this proposal is to establish a deep, comprehensive and quantitative understanding of cristae biogenesis in human cells. Using theses insights, we will also investigate the effects of mutations in mitochondrial proteins associated with human diseases on cristae biogenesis. Altogether, if successful, the outcome will represent a paradigm shift in our knowledge of how mitochondrial ultrastructure in healthy and diseased cells is generated and maintained. Our findings might spark innovative and novel strategies for the treatment of devastating human mitopathies.

Keywords: mitochondrial ultrastructure,inner membrane architecture,super resolution microscopy
Services enhancing the innovation management capacity of SME's and Key Account Management in Niedersachsen / Lower-Saxony (N-Supp_INNO-20-21)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 244167.5
EU funding (EUR): 244167.5
Participants: 3
Project status: CLOSED

EEN Niedersachsen - Enhancement of Innovation Management Capacities of SMEs and Key Account Management for SMEs. To achieve the above mentioned objectives the Network partners will: 1. Increase the efficiency and effectiveness of innovation processes in small and medium sized enterprises with significant innovation activities that could potentially become beneficiaries of European support programmes for research and Innovation, but do not have sufficient access to consulting services for innovation management. This service, provided independently from a specific innovation project and focusing on a company's innovation management system, is called Enhancing the innovation management capacity of SMEs (EIMC). Due to staff restriction EEN Niedersachsen Partner Hochschule Osnabrück will not apply for this call. The two partners Leibniz University Hannover and NBank ill deliver minimum 56 EIMC actions as described in Work package 1 as 7-10-day-packages 2. Identify bottlenecks in the creation of economic impact in companies benefitting from grants under European Innovation Council Instruments (accelerator and pathfinder) or Horizons 2020's SME instrument and address these bottlenecks with the help of capable coaches. This service to beneficiaries of the EIC/ SME instrument in the context of a given project is called 'Key Account Management'. Partner NBank will provide this service to all companies successful in their proposals in the funding schemes SME Instrument, Fast Track to Innovation and Future and Emerging Technologies Open as well as EIC accelerator and pathfinder projects. • Partner NBank plans to deliver 8 Key Account Management actions as described in Work package 2 as 7-day-packages related to successful proposals for the mentioned funding schemes from the region.

Keywords: eimc,enhancing innovation management capacities of smes,niedersachsen
i2D – intelligence to drive (i2D)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Portugal
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Road Transportation represents a growing problem to be urgently solved by modern societies. More than 1 million vehicles, producing 25% of all CO2 emissions, consuming 30% of all available fossil energy and being the cause for more than 1.200.000 casualties, every year. LiveDrive promoters, dedicated long years of R&D analyzing data driving dynamics and how to transform this raw data into valuable information. This effort was the major source to the i2D – Intelligence to Drive project, a Car Telematics Platform to collect raw data from the driving dynamics, transformed into valuable information, using complex innovative algorithms, available to all potential users of the road transportation ecosystem. The R&D stage of i2D project, co-sponsored by FAI (www.fai.pt) made proof of the basic ideas and the underline technologies, building a platform with 400 vehicles connected in 8 countries, collecting several thousand million data, processed by multiple complex innovative algorithms with special care to the area of privacy data protection. Innovation is at the core of i2D, both from the technical side (unique electronic devices, innovative algorithms, privacy protection mechanisms and Information Systems Architecture) and the business side (concept of “collect once/sell to many”). Key business areas include, major fleets (with a new wave of Advanced Fleet Management Solutions, focused in the promotion of a new Driving Behavior), the Insurance Business (the UBI – Usage Based Insurance, solutions are expected to grow from more than 250 million users (USA and EU) by the end of the decade), the Local and National Authorities (to improve traffic management and safety and allow Pay How you Drive policies) to the end user – the Driver, that will be the beneficiary of all road mobility improvements. The feasibility assessment to be done during this Phase 1 is a key step for a professional approach to leverage financial resources to perform the go-to-market next stage.

Keywords: smart transportation,eco driving,vehicle infrastructure vehicle,vehicle to vehicle communications,business intelligence over big data
Seizing the Hybrid Areas of work by Re-presenting self-Employment (SHARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Italy,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-09-01
End date: 2023-11-30
Duration (months): 75.0
Total project cost (EUR): 1258250.0
EU funding (EUR): 1102876.35
Participants: 2
Project status: SIGNED

SHARE is a transdisciplinary and multi-method study of the work arrangements which destabilize the dichotomies between standard and non-standard work and between self-employment and dependent employment. More specifically, it will research solo self-employment, namely self-employment without employees. This is a growing contractual category in Europe which comprises very different subjects, often disguised by statistics and difficult to represent by unions: from independent professionals to ‘fake self-employed’ workers legally self-employed but in fact wholly dependent on the company. Therefore, I introduce the concept of ‘hybrid areas of work’ to refer to the co-existence of features usually attributed to categories traditionally kept sharply distinct. SHARE will study the emergence of hybrid areas of work through comparative research in six European countries: Germany, France, the Netherlands, Italy, UK and Slovakia. Despite the overall large increase of solo self-employment, path-dependency connected to welfare state traditions has induced national legislators to adopt distinct strategies of labour-market (de-)regulation and adjustment of social security systems, producing different consequences on both social protection and collective bargaining. The research programme will make a significant contribution to the advancement of studies on work, employment and industrial relations by moving towards a theoretical rethinking of the categories used hitherto to interpret work and employment. It will combine comparative analysis of labour laws and labour force surveys, both at the EU and national level, with a cross-national ethnography able to inform both macro and legal perspectives with an on-the-ground approach to the forms of collective representation of solo self-employment. By researching how the solo self-employed are classified, measured, and represented, SHARE will furnish societally relevant findings, thus providing both theoretical and applied advancement.

Keywords: new forms of labour,eu and comparative analysis of social protection and employment,collective work identities,collective representation of workers,union organising,organisational ethnography
MicroLAB lab-on-a-cartridge, a disruptive concept. Towards an innovative solution for food safety (MicroLAB)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main aim of this proposal is to generate an updated revision of GTZ’s initial Business Plan (BP I), to overcome the main challenges detected for the successful MicroLAB market launch. The following aspects will be pursued: 1) specific marketing tools and sales strategy (Europe, North and South America, Asia) devoted to feedstock producers and micro & small food companies (≤50 employees), to speed up, the market share achievement (2,6%); 2) product innovation policy to assure the company growth in the food safety business; 3) technical feasibility study for a cost-effective production process (<5 €/device) and its lay-out definition; 4) revision of the organization growth plans to assure its sustainability; 5) and an updated review of the economical and financial plans. The food sector is the second largest manufacturing industry micro, small and medium sized companies suppose the 99. The business size profile has a relevant impact on the deployment of the safety assurance measures and the feedstock sustainable production (minimization of waste and GHGE). Due to the micro and most of the small companies’ size (< 20 employees), the accomplishment of the mandatory plans for quality and food safety assurance, makes of it a big hurdle difficult to overcome. Alternative rapid kits have been developed to facilitate food pathogen assessment, but none of them, covers the whole microbial detection routine in an easy and affordable way. So, micro and small food companies ought to outsource this service (18-20 €/test, 8,500 €/year), with the added drawback of relying a very sensitive issue in third parties. The small dairy, meat and poultry farms, can’t cover these controls, being assumed by the secondary transformers, with the additional costs of logistics, cross-contamination and factory’s stops, if feedstock refuse. The solution has been carefully considered, and it’s a challenge that GTZ is eager to assume, by the manufacture and the market launch of MicroLAB.

Keywords: growth,sales strategy,cost effective process,food safety,microbial pathogens,sustainability,salmonella,lysteria monocytogenes
Into the Eastern Desert of Egypt from the New Kingdom to the Roman period (Desert Networks)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 1499844.0
EU funding (EUR): 1499844.0
Participants: 1
Project status: CLOSED

The desert is a paradox: it is at the same time arid and rich in resources, a margin and an interface. Far from being a no man’s land, it is a social space of linked solidarities. The “Desert Networks” project aims to explore the reticular organisation of such a zone by focusing on the southern part of the Eastern Desert of Egypt. Located between the Nile and the Red Sea, it has always been a tantalizing region for Egypt and beyond. Its ancient remains are admirably preserved and ancient sources about and from the region itself are numerous. Yet, the history of its occupation and appropriation remains a static and compartmentalized one. Therefore, the ambition of the project is to cross disciplinary borders and achieve an epistemological break by working for the first time in and on the Eastern desert as a dynamic object, both from a long-term perspective (mid-second millennium BC - late third century AD), and by analysing the patterns and functions of the different networks that linked its various nodes using the connectivity theory that reshaped scholarly paradigms for the Mediterranean in the 2000s. As the head of the French Eastern Desert mission, the PI will co-ordinate a multidisciplinary team. For the first time, the project will gather all the data unearthed in the region over 300 years, as well as the expected data from the excavations conducted by the project, in a database linked with a GIS. A collaborative and online open access map of the Eastern Desert will be created and will serve for the spatial analyses and rendering of the real, economic and social networks in the area. These networks evolved over time and through a shifting geography, as people experienced different perceptions of space. By assessing all these facets and confronting the archaeological material and written evidence, our final objective is to write a new history of the Eastern Desert from Pharaonic to Roman times, focusing on its networks and evaluating their meaning.

Keywords: archaeology,ancient history,egypt,eastern desert,red sea,new kingdom,graeco roman period,communications networks,economic networks,social networks,greek papyrology,pottery
Infrastructure for transnational access and discovery in structural biology (iNEXT-Discovery)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Germany,Germany,Spain,Italy,Hungary,Lithuania,Sweden,Greece,Poland,France,France,France,Czechia,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,Portugal,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2019-1, 2019)
Start date: 2020-02-01
End date: 2024-07-31
Duration (months): 54.0
Total project cost (EUR): 9987743.83
EU funding (EUR): 9987743.83
Participants: 28
Project status: SIGNED

Structural biology reveals the molecular architecture of life; the three-dimensional structure of biomolecules and how they interact to form complex machineries and cells. Structural biology is key to innovations in chemistry, biotechnology and medicine: new drugs, advanced vaccines, novel biomaterials, engineered enzymes for food production, a cleaner environment, and efficient biofuels. iNEXT-Discovery takes on the challenge of proactively supporting the uptake of existing tools, and the innovation of new tools, to promote scientific Discovery and translation in a range of disciplines, building on the success of the H2020 project iNEXT (infrastructure for NMR, EM and X-rays for Translational research). iNEXT-Discovery brings together a strong network of leading structural biology facilities in partnership with regional experts and ESFRI communities in medicinal chemistry, translational medicine, biological imaging, and food research, to disseminate knowledge and services. We aim to stimulate the wider uptake of structural biology across Europe, across scientific disciplines and research sectors. Significant hardware and software advances allow targeting transnational access to advanced instrumentation also to scientists without previous expertise in structural biology: uptake will be facilitated by training and thematic calls focused on new communities. Access to our instrumentation and expertise will ultimately allow European scientists to gain structural insight that can translate into innovations in the biomedical, food, biotechnological and biomaterials sectors. Our joint research activities will roll-out advances in key technologies for translational research: fragment screening for drug development, EM efficiency and capacity, NMR applications to extend structures beyond three dimensions, and integrative structural biology approaches to look at macromolecules in cells. All our activities support innovative research of both academic and industrial users.

Keywords: structural biology,crystallography,protein,translational research,drug discovery,health,food,biotechnology
Magnetic non-volatile Random Access Memory for SPACE with Serial interface (MNEMOSYNE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Italy,Sweden,Belgium,France,France,France
Call: Technologies for European non-dependence and competitiveness (H2020-SPACE-2019, 2019)
Start date: 2020-01-01
End date: 2024-01-31
Duration (months): 49.0
Total project cost (EUR): 3038989.38
EU funding (EUR): 3038380.0
Participants: 6
Project status: SIGNED

Memories are critical components for space applications. They can be separated into three types: mass, cache and program memories. The latter permanently stores a program which can be executed as a MCU boot memory or FPGA configuration non-volatile memory (NVM). In space applications, the program memory is the one which requires the highest reliability, zero error tolerance, and the highest radiation hardness as it is directly related to the system power up. On the other side, as the requirements of system performance increased, integrated circuits (IC) are more and more dense. The recent space program memory requires higher speed and density. For example, the European rad-hard FPGA BRAVE NG-Medium requires at least a 13Mb configuration. The next generations NG-large, and NG-Ultra will require 128Mb and up to 512Mb high speed, low pin-count configuration memories. Currently, for this critical memory, there is no European radiation hardened memory component available. MNEMOSYNE project aims to develop (design and prototype) the new generation of radiation hardened high density NVM with serial interface based on most-advance and matured European commercially available 22 nm FDSOI Magnetic RAM (MRAM) technology. Thanks to FDSOI semiconductor structure, this process naturally provides good radiation tolerance. In addition, MRAM technology is naturally SEU immune. Key innovations are: • The first European RHBD (radiation hardened by design) space NVM with density higher than 1Mb; • The first World Wide RHBD space NVM with density higher than 16Mb; • The first European embedded RHBD high performance space NVM IP core on process lower than 65nm; • The first new generation Spin-Transfer Torque (STT) MRAM for space application; • The first RHBD applied on 22nm FDSOI on both digital and analog IPs’ for TID & SEE mitigations; The development of a high density MRAM will reshape the whole memory chips market for space industry and beyond.

Keywords: radiation hardening,non volatile memory,3d stacking,fdsoi,space applications,aviation applications,european non dependence,stt mram,radiation hardening by design
The Brexit effect in media coverage: how the intra-party democracy counters the rise of European populism (POSTBREXIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2020, 2020)
Start date: 2020-05-01
End date: 2022-06-30
Duration (months): 26.0
Total project cost (EUR): 12194.25
EU funding (EUR): 12194.25
Participants: 1
Project status: CLOSED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Keywords: brexit,populism,euroscepticism,europe,intra party democracy