Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From immigrants to colonialists? Italians in Egypt and "the others": fragments of subaltern agency in a Colonial sea (1861 - 1911). (SubColonialMed)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

What was the shared experience of global cities in the southern and eastern Mediterranean during the second half of the 19th century? How did the subaltern classes experience the processes of modernization and colonialism? The aim of SubColonialMed is to offer new insights into socio-historical questions regarding the link between migrations and colonialism in the late 19th, early 20th centuries. The project is based on the Italian migration to Egypt but seeks to broaden its analysis to encompass the entire Mediterranean Italian diaspora. It examines the hypothesis that Italian "colonies" in the Mediterranean region were pivotal to the foreign and colonial policy of the Kingdom of Italy, contributing significantly to the shaping of national identity. I argue that, even before the occupation of Lybia, the communities in territories subject to the Capitulations legal system served as laboratories for the construction of Italians as national and white political subjects. However, it is a mistake to perceive a direct correlation between metropolitan colonial politics and mass migrations. Operating under the assumption that social transformations arise from global and local processes, this research regards migration as a social-historical phenomenon involving specific and autonomous dynamics of appropriation, hybridization, and rejection. Methodologically, it strives to break new ground by proposing a interdisciplinary study with three components: consular archives, judicial documents, and qualitative biographical data, all used to explore these connections. Combining the micro historical approach with post-colonial theories and intersectional method the project want to test how Italian subalterns in Egypt appropriated nationality becoming colonial actors. The goal is to arrive to fundamental new insights about the interethnic relations of ordinary people in the cosmopolitan cities of Egypt and in the rest of the region.

Keywords: italian diaspora,colonial history,subalternity,capitulations,cosmopolitanism,contemporary egypt,mediterranean region
MAterials design at the eXascale (MaX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Italy,Slovenia,France,Spain,Germany,Czechia
Call: Centres of Excellence preparing applications in the Exascale era (HORIZON-EUROHPC-JU-2021-COE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 8496392.5
EU funding (EUR): 4248196.0
Participants: 16
Project status: SIGNED

Understanding, predicting, and discovering the properties and performance of materials is key to delivering the technologies that power our economy and provide a sustainable development to our society. For this reason, materials simulations have become one of the most intensive and fast growing domains for high-performance computing worldwide, with a recognized European leadership in developing and innovating the ecosystem of quantum simulation codes. MaX will target these lighthouse codes to address the challenges and leverage the opportunities arising from future exascale and post-exascale architectures, and to offer powerful paths to discovery and innovation serving both scientific and industrial applications. MaX includes (1) the core developing teams of the European lighthouse codes; (2) the HPC centres designing and hosting pre-exascale and exascale systems; (3) the main European companies engaged in the development of exascale technologies; and it brings (4) a sustained record in training and educating the community, and (5) in disseminating its resources under an extensive open-source model that includes codes, workflows, and FAIR data. These synergies will underpin the objectives of the present proposal, that aims to upscale the MaX codes and their performance to multiple heterogeneous exascale architectures; to endow these codes with innovative capabilities enabled by such architectures; to co-design the hardware and software in collaboration with the relevant European stakeholders; to enable turn-key simulation capabilities that meet the power of exascale resources and deliver the resilience needed; to disseminate the entire ecosystem of codes, workflows, and data; and to train and engage developers and users in fully leveraging such powerful instruments for discovery and innovation.

Keywords: lighthouse materials science codes at the exascale,co design based on materials science codes,energy efficiency in materials science codes,training on hpc for materials research
Cybersecurity Certification and Assessment Tools (CCAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Czechia,Germany,Italy,Estonia
Call: Approaches and tools for security in software and hardware development and assessment (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 4442544.4
EU funding (EUR): 4223156.08
Participants: 9
Project status: SIGNED

Cybersecurity regulations are becoming increasingly complex. The Cybersecurity Act (CSA) introduces an EU-wide cybersecurity certification framework, while the Cyber Resilience Act (CRA) sets mandatory cybersecurity requirements for products with digital components. A reliable and flexible set of tools is essential for continuous security assessment and navigating these evolving regulations. In the CCAT project, we propose adapting four open-source tools, developed in academic cybersecurity research, to support the implementation of new regulations: (1) TLS-Scanner for assessing security in TLS clients and servers; (2) SCRUTINY for evaluating cryptographic implementations, software libraries, and hardware, including black-box setups; (3) ALVIE for testing embedded security architectures against vulnerabilities; (4) sec-certs for analysing certification landscapes and evaluating the relationships between certified products and actual vulnerabilities. CCAT will enhance these tools to meet the needs of various users involved in or dependent on cybersecurity assessment and certification. The CCAT methodology builds upon: (1) Relevant feedback for purpose-driven enhancements enabled by collaboration with users applying the CCAT tools in diverse application scenarios. (2) Robust usable security research exploring and collaboratively improving user interaction with the tools. (3) Aligning the tools with the emerging EU security certification landscape. CCAT tools aim to empower both ICT producers and consumers, fostering a more transparent, accountable, and resilient digital environment. Regulatory bodies can use these tools to assess the effectiveness of cybersecurity certifications, verify the security of specific implementations, and ensure the EU digital single market cybersecurity.

Keywords: security assessment security certification independent verification open source transparency
Studying viral protein-primed DNA replication to develop new gene editing technologies (Viral DNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1641428.0
EU funding (EUR): 1641428.0
Participants: 1
Project status: SIGNED

There are over 6,000 human genetic diseases, affecting hundreds of millions of people. The vast majority are caused by small mutations in DNA sequences which are potentially correctable, so the development of new gene editing tools will have major benefits for treating human genetic diseases. To tackle this challenge, we will harness the natural protein diversity of viruses to create new gene editing technologies. We will study an unusual class of viruses that use a unique mechanism to replicate themselves, known as protein-primed DNA replication, which creates the rare feature of a protein-DNA covalent bond. These viruses are very understudied, yet they hold great potential for new biotechnology applications. We will study the protein-primed DNA replication machinery of these viruses, and then exploit this mechanism to develop a novel technology for synthetic biology – creating new ways to amplify and deliver DNA into living cells for gene editing. Our research represents a major breakthrough on two accounts: Firstly, to discover and characterise large numbers of protein-primed DNA replication proteins from previously unstudied viruses; to establish a highly efficient, self-replicating system able to synthesise and amplify large amounts of protein-linked DNA product; and to study the molecular details of these viral replication proteins for the first time. Secondly, to develop protein-linked DNA as a new platform technology for gene editing. Our strategy to engineer viral proteins will create protein-linked DNA molecules that are for the first time (i) actively nuclear-targeted and (ii) self-replicating, to address key limitations in the gene editing field and pioneer a new method for highly efficient homology-directed repair. Overall, our proposal combines fundamental biological study and applied biotechnology research to transform our understanding of these viral proteins and engineer them for ground-breaking advances in gene editing and DNA delivery.

Keywords: synthetic biology,gene editing,protein engineering,molecular biology,virology,bioengineering
Topological solitons in ferroics for unconventional computing (TOPOCOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Norway,Germany,Luxembourg,Netherlands,Italy,Greece,Austria,Switzerland,United Kingdom,United States,Estonia
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2911488.69
EU funding (EUR): 2683972.8
Participants: 20
Project status: SIGNED

TOPOCOM is a network of leading European groups from different disciplines and sectors selected to provide comprehensive training on the integrative concepts underlying the science of topological solitons in ferroic materials and their application in unconventional computing. Topological solitons are a rich source of emergent physical phenomena and most promising nanoscale systems for future technology, enabling conceptually new pathways for low-energy information processing and sensing, as well as integrated data storage. Many of the developments in the field have occurred only in the past few years and it is clear that we have only scratched the tip of the iceberg concerning the topological solitons that form in electrically or magnetically ordered materials. To realize their potential, the consortium comprises the best groups in materials synthesis and modelling to stabilize such solitons, modelling and studying their dynamical responses to external stimuli, and designing and fabricating devices, where solitons carry out ultralow-power computing and sensing functions. While clearly a challenging topic, there are major benefits that result from a unified treatment of electric and magnetic solitons as realized in this TOPOCOM. The network spans the whole range from fundamental physics and applied materials science - linking both experimental and theoretical aspects - to industrial-scale production and evaluation. The scientific part (“Training through Research”) is complemented by advanced transferable business and cultural skills training (“Training for Life”), providing Europe with a unique training programme at the forefront in unconventional computing based on electric and magnetic solitons. TOPOCOM will establish innovative solutions for more sustainable information technology and educate the next generation of experts, highly qualified to tackle the technological key challenges of growing complexity in an important sector for EU economic development.

Keywords: topological solitons,skyrmions,topology,ferroelectrics,ferromagnetism,ferroics,unconventional computing,low power devices,information processing,magnetic sensing
Screening protein translocation during cell differentiation with temporally multiplexed imaging (TranslocScreen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 266987.28
EU funding (EUR): 266987.28
Participants: 2
Project status: SIGNED

During differentiation, dramatic changes occur in the biochemical processes and the architecture of cells. The subcellular localization of proteins greatly impacts their function and also the transformations during cell differentiation are accompanied or facilitated by protein translocation. In the proposed research project, I want to systematically study how proteins translocate during the differentiation from neuronal stem cells into neurons and astrocytes. To this end, I aim to develop a general and efficient screening method for protein translocation during cell differentiation. I envision to identify protein translocation behavior that is essential for neurodevelopment and direct reprogramming, which I plan to confirm in brain organoids, which include diverse cell types. Additionally, I want to study the underlying mechanisms both initiating and initiated by protein translocation. The method will be based on fluorescence microscopy, which will allow me to observe the dynamics of protein localization in living, differentiating cells. To increase the efficiency of the screening approach, I want to implement a recently published multiplexing strategy, temporally multiplexed imaging (TMI). This method uses the photo-switching kinetics of the utilized fluorescent protein (FP) labels to deconvolute up to 6 signals in a single spectral channel. In this way, I can label several proteins per cell multiplying the efficiency of the method and enabling the screening of a large panel of proteins. I will label these proteins with TMI-compatible FPs through gene editing. Imaging of the edited cells throughout the differentiation process and subsequent automated image analysis will identify translocating proteins. The gained mechanistic knowledge about neuronal cell differentiation will improve our basic understanding of this process eventually facilitating the development of improved disease models as well as medical applications such as reprogramming.

Keywords: cell differentiation,protein translocation,multiplexed fluorescence imaging,multiplexed gene editing
Rational design of polymerized IONic liquid electrolytes for MultivAleNt ion batteries (ION-MAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: CLOSED

With global battery demand projected to increase by 25% per year till 2030, it is urgent to overcome the limitations of commercial Li-ion batteries in terms of energy density, safety, cost and carbon footprint. Batteries based on multivalent chemistries can reach significantly higher energy densities at lower costs. In particular, magnesium has very high volumetric capacity, low reduction potential, no toxicity, it is easier to handle than lithium, and 3000-times more abundant and more geographically widespread. Therefore, rechargeable magnesium batteries (RMBs) can enable safe, low-cost, high-energy-density energy storage, contributing to the energy security and the creation of a competitive battery ecosystem within the European Union. The major barrier to RMBs is the lack of Mg-conducting electrolytes that allow reversible, charge efficient plating/stripping of metallic Mg. ION-MAN will develop a new family of high-performing electrolytes for RMBs based on polymerized ionic liquids (PILs). The rationally designed electrolyte structures combine the strengths of previously reported Mg-conducting electrolytes, to the exploration of topological effects. An integrated, multi-technique approach that uses advanced characterization tools will enable to measure physicochemical properties, and propose suitable long-range charge migration mechanisms for the electrolytes. Despite the bivalency of Mg2+ leads to strong interactions with anions and solvents, the proposed methodology will allow for accurately identifying the mobile Mg species, their interactions with other components and their reactions with both electrodes of an RMB. Thus, the compatibility with Mg metal anode and selected cathodes will be thoroughly investigated, defining requirements for device optimization, toward safe and practical RMBs.

Keywords: mg batteries,polymerized ionic liquids,polymer electrolytes,mg metal anode
MiniTweezer: Optical Tweezers with Automation and Artificial Intelligence (MiniTweezer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-03-01
End date: 2026-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Optical tweezers have revolutionized various scientific disciplines, especially single-molecule research and single-cell mechanobiology. For example, they have played a fundamental role in understanding the folding dynamics and mechanical properties of DNA. In 2018, recognizing their importance, Arthur Ashkin was awarded a share of the Nobel Prize in Physics for the invention of optical tweezers and their application to biological systems. However, even though their broad range of applications attracts interest and potential users from many different fields, the expertise in optics and physics needed to operate optical tweezers has limited their accessibility to non-specialists. To address this challenge, we have developed a compact optical tweezer, named MiniTweezer, that is capable of autonomously performing advanced experiments thanks to its Python application programming interface (API) and its integration with advanced AI tools. We have already demonstrated its automation capabilities not only in the classical pulling of a DNA molecule, but also in stretching red blood cells (of interest for medical diagnostics) and in measuring electrostatic interactions between colloidal microparticles (of interest for the consumer goods industry). Preliminary market analyses show that the MiniTweezer is of great interest to academia and industry thanks to its ability to perform automatized and high-throughput experiments in life sciences and colloidal sciences. This project aims at improving the MiniTweezer to obtain a more user-friendly and powerful device and make it available to a broader research community to test in different use-case scenarios and to gather valuable end-user feedback. The ultimate goal of this project is to create a start-up company to commercialize the MiniTweezer.
Unveiling the mysteries of stellar dynamics: a pioneering journey in magnetoasteroseismology (Calcifer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1499309.0
EU funding (EUR): 1499309.0
Participants: 1
Project status: SIGNED

While stellar evolution has been considered one of the most well-understood astrophysical processes for decades, a massive revolution is in motion thanks to probes of dynamical processes in stellar interiors with asteroseismology. Through this study of stellar oscillations, core rotation-rate measurements point out a very efficient extraction of angular momentum in the depths of stars. It represents one of the most fundamental, yet poorly understood, processes throughout stellar evolutionary journeys. This critical knowledge gap casts significant doubt on our ability to accurately date astronomical objects in the Universe using current stellar models, as an efficient angular momentum transport would bring fuel to the burning core and therefore extend the life of the star. Intermediate-mass stars (IMStars) are the perfect laboratory to elevate our understanding of angular momentum transport in stars, as their structure and internal dynamics resemble that of low-mass stars in the late stages of evolution, as well as high-mass stars during the earliest stages. The recent discovery of surprising oscillation mode frequencies and amplitudes revealed the presence of stable magnetic fields in the radiative core of a few red giant stars, similar to fields observed at the surface of 10% of IMStars during the preceding phases and later on when they lose their envelope. The Calcifer ERC project aims at pioneering magnetoasteroseismology, through an unprecedented exploration of the evolution of magnetic IMStars. We will use observed stellar oscillations to unlock the invisible, unveiling magnetic processes controlling the dynamics of the plasma in the depths of IMStars along their evolutionary journey. The ultimate objective of this ambitious and unifying project is to deliver the first meticulously informed model of the magnetized evolution of IMStars from birth to death, fundamentally impacting our ability to date structures in the Universe.

Keywords: stellar evolution stellar magnetism stellar rotation stellar ages asteroseismology