Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Introducing Disruptive Inline Monitoring for Process Health in Filling and Heat-Sealing Operations (PAM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The packaging integrity of any product is crucial to ensure product viability and shelf life, especially in life-dependent markets such as food and beverages. A broken seal or incorrect moisture level can lead to contamination, degradation, and leaks, causing economic losses and brand reputation damage. Currently, there is no method to quickly detect sealing flaws or understand why they occur. The prevailing methodology is sampling, which generates waste, recalls, unsafety, and unreliability. Existing testing techniques are limited, often relying on destructive sampling without feedback for process improvement or root cause analysis. Over 95% of food companies using heat-sealed packaging still rely on manual testing. We have developed the PAM System (Packaging Analytical Monitoring system), a disruptive quality control system that analyzes all products in a batch via 3D thermal imaging and advanced real-time algorithms to provide complete in-line monitoring of the packaging process. Our heat sealing system (PAM-HS) is at TRL7 after rigorous testing and validation in laboratory and pilot-scale environments, and our moisture content monitoring system (PAM-MCM) is at TRL5. These systems screen 100% of products non-destructively without slowing line capacity. Our Deep Learning algorithms collect precise data to increase process understanding, improve quality, allow real-time issue detection and amendment, and identify patterns, such as sealed areas too close to user-set limits. Through the blended EIC Accelerator, our goal is to establish the essential correlation between thermal radiation and moisture levels while also advancing AI capabilities to identify the root causes of process degradation. While finalizing PAM-MCM development, we plan to launch PAM-HS to the market with EC investment support. Both systems are complementary; PAM-HS will pave the way for PAM-MCM launch.

Keywords: monitor and diagnostics,food packaging quality,thermal imaging,ai,process health,process control,heat sealing monitoring,moisture content monitoring,sustainability,designed for recyclable d4r
Forgotten Dreams of Mao’s Ousted Class: An Intimate Ethnography on how the Chinese Intelligentsia Survived the Mao Zedong Era (Forgotten Dreams)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 189209.28
EU funding (EUR): 189209.28
Participants: 2
Project status: SIGNED

This project combines history, anthropology and politics to complicate official representations of Chinese history told by the current regime of power. Starting from my own family history, which sits at the core of this research, Forgotten Dreams of Mao’s Ousted Class is guided by the stories of my Chinese grandfather and Finnish grandmother as a mixed-racial couple of the intelligentsia class at a time of political transformation when an imagined socialist future seemed within grasp. In a novel enquiry to re-conceptualize how collective memory is transmitted, this first ever state-of-the-art ethnographic project documents and analyses silenced stories of grievous loss and trauma of the Chinese educated elite to reconsider what lurks beneath the nation’s autocratically monitored socialist dream that holds post-Mao Chinese society together. My three-year postdoctoral project is an intimate ethnography that bridges ethnography and biography to offer a new methodological approach to studying the transmission of loss by state violence in contemporary history. Professor Alisse Waterston, the supervisor for the outgoing phase at City University of New York (CUNY), and Professor Maarit Forde, the supervisor for the return phase at the University of Helsinki (UH), will support my work and mentor me to deliver an innovative and novel intimate ethnography monograph that combines methodology and theory; politics and ethnography; the personal and the historic.

Keywords: intimate ethnography,ethnography,social history,mao zedong rule,intelligentsia,china,political violence,memory,recollection
A novel combination treatment effective against all multidrug-resistant pathogens deemed as a critical priority by the WHO (sbli-ant3310)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-12-31
Duration (months): 35.0
Total project cost (EUR): 5618870.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Antimicrobial resistance (AMR) due to multidrug-resistant Gram-negative bacteria are an increasingly serious healthcare threat, exacerbated by major economic issues underlying the development of new antibacterial drugs. The effectiveness of β-lactam antibiotics, the most important class of antibacterial agents, is impaired by the production of β-lactamase enzymes by drug-resistant bacteria. We are developing a combination of a well-known antibiotic (meropenem) and ANT3310, our proprietary, best-in-class serine-β-lactamase inhibitor, intended for the treatment of hospital-acquired infections caused by drug-resistant pathogens. Our treatment has been pre-clinically proven to be efficacious against all three pathogens deemed a critical priority by the World Health Organization (WHO). We will conduct three clinical trials and next out-license ANT3310 to a pharmaceutical partner. We expect market approval by 2029 and that ANT3310 will generate over €10bn in sales within 13 years.

Keywords: infectious diseases,carbapenem resistant enterobacterales,ancinetobacter baumannii,pseudomonas aeruginosa,drug development,serine lactamase inhibitor,complicated urinary tract infections,nosocomial pneumonia,antibiotics,critical priority pathogens,antimicrobial resistance
Protein Ruler to Create Affordable Biosensor Diagnosis for the Many (PRABio)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-09-01
End date: 2025-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Ovarian cancer is the most common malignancy of the female reproductive system worldwide, and the leading cause of death from gynecological cancer. However, if diagnosed during the early stages, patients have a good prognosis, at around 90% 5-year survival rate. Despite its lethality, there are currently no effective simple tests for diagnosis nor population-based screening techniques for ovarian cancer. Emerging tests detecting cancer biomarkers have the potential for greatest impact for surveillance and early detection, such as the FDA approved CA125 and HE4 biomarkers. Importantly, because the levels of these biomarkers are not the same among all healthy females and increase with age, these tests should be quantitative. Current quantitative diagnostic tests for CA125 and HE4 detection are expensive, require high-cost infrastructures and trained professionals. Therefore, there is an urgent need for developing cheap, reliable, easy-to-use quantitative tests for ovarian cancer biomarkers. In this project, ground-breaking innovating research will give rise to novel technology, enabling the detection of cancer biomarkers in a manner that is quantitative, and yet simple, portable and cheap.
Antigen-specific treatments to target autoimmune kidney diseases (AUTO-TARGET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1499662.5
EU funding (EUR): 1499662.5
Participants: 1
Project status: SIGNED

Chronic kidney disease (CKD) affects around 10% of the population worldwide and is associated with significant overall and cardiovascular mortality. CKD is a heterogeneous group of disorders characterized by alterations in kidney structure and function and is progressive in nature. Autoimmune diseases are a common cause of CKD and responsible for its most aggressive and progressive forms, mainly in younger patients. Autoantibodies play major pathogenic roles in most of these disorders and multiple disease-specific target antigens have been identified – circumstances that have shifted treatment strategies from largely unspecific immunosuppression towards B and plasma cell-targeted therapies. However, such treatments still involve broad immunosuppression with potentially severe adverse effects. Hence, there is a huge gap between the increasing insights into the immune mechanisms and pathogenic role of autoantibodies against cellular antigens on the one side and the currently available treatments with limited specificity on the other side. The vision of AUTO-TARGET is the development and experimental implementation of pathogenesis-based and antigen-specific treatments for autoimmune diseases of the kidney. The objectives are (1) to identify and characterize novel molecular targets on autoantibody-secreting cells, (2) to target autoreactive B and plasma cells using nanobody-based compounds, and (3) to engineer chimeric autoantibody receptor NK and T cells for the treatment of different autoimmune diseases of the kidney. AUTO-TARGET thereby revolves around a highly translational approach, combining target identification and characterization in patients with autoimmune kidney diseases with unique in vitro and in vivo systems to model disease and validate therapeutics. These translational studies pave the way for more specific, less toxic treatments and thus may implicate a huge step forward for the large and growing population of patients with kidney disease.

Keywords: autoantibodies,monoclonal antibodies,nanobodies,bispecific antibody recruiters,antibody secreting cells,autoimmune disease,membranous nephropathy,minimal change disease,systemic lupus erythematosis,rapid progressive glomerulonephritis
Far-Infrared to Radio Search for disTant Dust-obscUred galaxies and STructures (FIRSTDUST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

We are at a tipping point where unveiling the nature of distant dust-obscured galaxies and the formation of the first proto-clusters in our Universe is finally possible thanks to recent advances in multi-wavelength astronomy. Taking advantage of a unique ensemble of deep, large-area data sets from the far-infrared (FIR) to radio wavelengths in the COSMOS and H20 fields, I propose the project FIRSTDUST (Far-Infrared to Radio Search for disTant Dust-obscUred galaxies and STructures) that will provide: a complete characterization of the dust-obscured star-formation rate density (SFRD) at z = 2–6, and robust constraints on the contribution of previously undiscovered galaxy (proto)clusters to the SFRD. FIRSTDUST will also deliver the census of dusty star forming galaxies and proto-clusters, providing invaluable targets for the upcoming next-generation telescopes (e.g. JWST, E-ELT). I have unique expertise on producing multi-wavelength photometric catalogs by synthesizing data from IR and radio telescopes, and sophisticated data processing and measurement skills with (sub)mm interferometry (ALMA, NOEMA and ATCA). G. Magdis’ group at DTU Space has exclusive access to JWST MIRI GTO data and unique expertise to support the analysis with the FIR+(sub)mm data. The Cosmic Dawn Center (DAWN) has been constructing the largest, exclusive access data sets in the IR side and leading the 50 square degree DAWN survey, which is essential to this project. My dedicated work at DTU & DAWN is thus the best synergy to realize the proposed project.

Keywords: galaxy,galaxy cluster,high redshift,dust emission,far infrared,radio
FLUOROgenic probes for rapid assessment of immunoTheRAPies in precision oncology (FLUOROTRAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Cancer is the second-leading cause of death globally with more than 10 million deaths worldwide in 2020. Immunotherapies can reactivate the immune system against tumors and are promising treatments for many types of cancer; however, only a small fraction of patients that receive immunotherapies show positive responses and it remains unclear what therapy is most suitable for every patient. There is a clear need for rapid, simple and functional assays that can rapidly evaluate the efficacy of anti-cancer immunotherapies to personalize treatment and accelerate precision oncology. This unmet need drives the development of FLUOROTRAP. The ERC CoG project DYNAFLUORS delivered the first fluorescent chemical toolbox for imaging immune cell activity in real time. During the treatment of cancer patients with immunotherapies, the activity of immune cells is indicative of how patients are responding to therapy. Granzyme B is a protein secreted by activated immune cells, such as T cells and natural killer cells; high enzymatic levels are correlated to strong anti-cancer immunity and therefore this biomarker holds potential to predict immunotherapy outcomes. We propose to develop a simple test to measure active granzyme B in cells and biosamples from cancer patients. This technology will advance personalized and precision oncology to ultimately improve patient outcomes, and it will also enable further research and drug discovery on anti-cancer immunotherapies. Funding from the ERC PoC will allow us to: 1) commercialize fluorescent reagents for biomedical research through licensing with industry, and 2) establish the foundations for new healthcare technologies to measure granzyme B activity in biosamples from cancer patients during immunotherapy treatment. This project will be guided by input from industrial partners and biomedical experts, and it will create multiple opportunities for cancer research and precision medicine.
Re-Valuing Urban Quality & Climate Neutrality in European Waterfront Cities (Re-Value)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Innovation actions
Countries involved: Norway,Belgium,Bulgaria,Italy,Portugal,Romania,Türkiye,Czechia,Croatia,Germany,Slovenia,Switzerland
Call: Urban planning and design for just, sustainable, resilient and climate-neutral cities by 2030 (HORIZON-MISS-2021-CIT-02, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 12418093.75
EU funding (EUR): 11999799.75
Participants: 26
Project status: SIGNED

In Re-Value, 9 European waterfront cities (Ålesund, Bruges, Burgas, In Re-Value, 9 European waterfront cities (Ålesund, Bruges, Burgas, Rimini, Cascais, Constanta, Izmir, Písek, and Rijeka) will test, capture and share how to create value through urban quality, in a holistic approach towards climate neutrality. They will cover 6 systemic challenges of urban planning and design, aligned with the Cities Mission: - Systemic changes in governance, regulatory structures, advocacy - Societal and spatial quality - Financial and circular value chains - Data-driven co-creation, digital twins - Energy and mobility - Nature-based solutions The model will be supported by 3 Innovation Cycles that run across the cities - Aligning climate neutrality and urban quality, using participatory story-building to identify co-benefits - Co-creating data-driven transition scenarios, empowering cities to use better data / data better - De-risking investments, through value-based financial and partnership models to enable the cities to document and capture different values in urban complexity, and to synthesise them into a holistic approach towards climate neutrality. Supported by this approach, the 9 Re-Value Cities will fine-tune, share and test a Portfolio of Urban Design and Planning Methods in the project’s Community of Practice. 4 Leading Cities (Ålesund, Bruges, Burgas, and Rimini) will demonstrate full-scale how integrated urban planning and design can be optimally deployed to achieve climate neutrality and significantly reduce GHG emissions by 2030. 5 Replication Cities (Cascais, Constanta, Izmir, Písek, and Rijeka) will learn, replicate and develop their own visions, scenarios and investment plans to accelerate their journeys to climate neutrality. While geographically and culturally diverse, the 9 cities share a curiosity and ambition to experiment, learn from each other, and share the Re-Value results and outcomes together with other cities in the Cities Mission communities.

Keywords: social innovation,culture,new european bauhaus,co creation process,story building,territorial transformation plans
The Global South in the Age of Early Industrial Capitalism: Commodity Frontiers and Social Transformations (1816-1870) (SevenFrontiers)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Our lives would be unthinkable without the production of millions of tons of cotton, sugar, palm oil or soy. All these commodities are obtained at the lowest possible price with often detrimental consequences for people and nature. The scale of the resulting environmental crises may be something of recent making, its mechanisms can be traced many centuries ago and are crucially part of the history of global capitalism. This project will go back to the pivotal decades when Europe recovered from the devastating Napoleonic wars, the Industrial Revolution picked up steam and global trade went through fifty years of rapid growth, a spurt even more spectacular than after the opening of the Suez Canal in 1869. Against this backdrop the project’s research team will examine the immense transformative effects of commodity frontiers in the Global South that fed the rise of early industrial capitalism. We will assess these transformations by taking the seven most exported commodities from the Global South as the unit of analysis (sugar, cotton, coffee, tea, precious metals (gold/silver), opium and cereals). We will map the wide-ranging and diverse social consequences of the massive mobilization of labour and land necessary to produce these commodities using an extensive historical database on global labour relations developed by an international group of scholars. We will further examine how these commodity frontiers were organized and financed by using underutilized archives of prominent locally and globally operating merchant houses. Finally, we will assess the actual contribution of the production of the seven commodities in the Global South to the upsurge of global trade. Data mining from digitized sources such as newspapers will allow us to identify trade patterns that so far escaped historical statistics. Thus, we will break new grounds in understanding how early on in the nineteenth century global trade and production patterns emerged that shaped the world of today.