Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A new EU Framework for an Ethical Re-use of Health Data (DataCom)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Spain,Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 3
Project status: CLOSED

The EU has recently enhanced the potential of health data in the EU digital market by promoting a number of initiatives and new regulations to facilitate data sharing and re-use among public institutions: the forthcoming provisions of the Digital Strategy Corpus of law. These, in combination with pre-existing rules and practices of health data exploitation, might sharpen the risks for citizens, for example allowing public bodies to exploit big data sets - to make detrimental decisions regarding the access of certain patients to health care (e.g., in the case of insurance-based systems). In this context, academic analysis is urgently needed, as well as suggesting a revision of the new regulations to EU policy-makers to facilitate responsible data sharing. DataCom aims at building a new framework to facilitate an ethical secondary use of health data held by public bodies, with the aim of improving accountability and enhancing responsible re-use. To build it, I will develop and test in intersectoral practical environments the innovative concept of “Ethical Commodification”: the possibility of exploiting personal data in an ethical way for the public good, in accordance with the data subject’s expectations and needs and taking into account the risks associated with the exploitation of anonymized data sets, focusing on 3 Member States, Italy, Spain, and the Netherlands. In order to reach this objective, DataCom has a strong interdisciplinary and intersectoral approach, bridging law, ethics, and computer science, taking into consideration the needs of the public sector and those of citizens. To ensure the successful implementation of these project goals I will conduct my research at the University of Turin's Law Department, with the guidance of Prof. Ugo Pagallo, a leading scholar. This project will prepare me to become a tenured scholar and obtain advanced funding, strengthening my academic profile and allowing me to establish my own research group.

Keywords: gdpr,digital strategy,health data,anonymization,eu law,data governance act,privacy law
Understanding Lightning from the Lab: Initiation, Propagation, and X-ray Emissions (Bottled lightning)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 2479429.0
EU funding (EUR): 2479429.0
Participants: 1
Project status: SIGNED

Despite the huge impact of lightning, its fundamental properties are still very poorly understood. With this project I want to build an infrastructure of carefully designed laboratory experiments in a novel physical regime, that will provide the conditions required to understand lightning phenomena. I will use this to answer some of the major open questions in lightning and high voltage discharge research. I will provide major scientific breakthroughs to answer the questions on 1) how lightning is initiated, 2) how lightning propagates by so-called leaders and 3) how these leaders emit energetic radiation (X-rays). The experiments will be complemented by dedicated numerical simulations for the best interpretation. Initiation of lightning within thunderclouds involves a complex, yet not understood interplay between electric fields, ice particles, charges and cosmic rays. I will have ice-like particles fall through varying electric fields in the novel discharge chamber and observe when discharges form and when they are strong enough to initiate lightning. Once initiated, lightning propagates through so-called leader discharges, but the exact mechanism has only been hypothesized. I want to understand how this is controlled by streamer discharges around it. During inception and propagation, lightning emits X-rays and other energetic radiation with energies far above expected electron energies. I will pinpoint the location and mechanism of such emissions with high reproducibility. The experiments will be unique in the world, due to the large discharge chamber, its highly controlled atmosphere, and its accompanying pulse source surpassing existing experiments by orders in voltage risetime and amplitude. This will expose new physical phenomena and thereby lead to great insights and uses: for the lightning community, validation of simulations and theories and understanding of lightning radio emissions, and for high voltage engineers tools to improve their devices.

Keywords: lightning,hydrometeors,gas discharge,laboratory experiments
Dramaturgies for languaging: Developing linguistically sustainable theatre and performance (DRAMALANG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

As European theatre, performance and film artists increasingly invite the diverse languages and language practices of a globalised, decolonial and postmigratory Europe into works across the stage and screen, pressing questions arise concerning the representation of minorities. Dramaturgies for languaging (DRAMALANG) aims to interrogate the core principles and systems driving European multilingual performance, articulate an interdisciplinary methodology for analysing the reproduction of potentially damaging knowledges for minority and low-status language speakers and make suggestions for linguistically sustainable dramaturgies to a new multilingual performance network. DRAMALANG asks the central research question: How are several languages and language practices invited into European dramaturgies to provide access to and legitimise the cultures and knowledges of minoritised and low-status language speakers? The secondary research questions are: How is a lingua franca other than Standard English negotiated in interactions?; and, how do the knowledges about minoritised languages and language practices within a European context rearticulate my findings about Indigenous and migrant languages in the global south? DRAMALANG will take shape at Aarhus University (AU), Denmark, through my observation of multilingual theatre, performance and film artists locally in Denmark and beyond, including Germany, Iceland and Romania. I will develop an interdisciplinary methodology between sociolinguistics and performance studies for analysing the reproduction of knowledge from multilingual dramaturgies and create a multilingual network of scholars and practitioners across the continent. I have pioneered a multilingual methodology like this in the global south. AU provides the necessary disciplinary guidance through the most specialised dramaturgies department in Europe and access to the artistic processes of innovative multilingual European artists through longstanding relationships.

Keywords: theatre,dramaturgy,multilingual performance,multilingual dramaturgies,knowledges
Medicine Made to Measure. (MMM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Netherlands,Hungary,Italy,Sweden,France,United Kingdom,United States
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 2500800.69
EU funding (EUR): 2198700.0
Participants: 23
Project status: SIGNED

Modern medicine seeks to personalize diagnosis and treatment to the needs of individual patients. This need is heightened in particular for those individual patients where no treatments are available – and where current standard treatment development paradigms exclude to generate such. The ultimate goal of Medicine made to Measure (MMM) is to go even beyond the latest genetic medicine approaches, implementing a novel paradigm of treatment development: the field of single patient tailored antisense oligonucleotide (ASO) treatments for patients with nano-rare disease mutations. Specifically, MMM will develop core modules of a novel “out-of-the-box”, but still EMA-advised treatment development path for these patients - from omics-based theranostics, via preclinical target validation to innovative trial methodology and a pioneering ethical framework for individualised genetic therapies. MMM provides a unique opportunity for doctoral candidates to be involved in building - and to receive training - in all core modules needed for tailored ASO treatment in Europe. This new scientific field requires a new generation of open-minded, technology-fluent and applications-oriented experts. MMM will help educate future drug development and translational experts in adopting and disseminating such a cross-specialty approach. Our idea for this innovative training network is built on our personal experience and understanding of the importance of single patient tailored genetic treatments in the years to come. We propose a consortium of world-leading experts and partners that present with extended experience and relevant know-how in molecular biology, neurology, translational medicine, biochemistry, bioinformatics, philosophy, mathematics, regulatory science and engineering. Thus, MMM provides an exceptional platform to young, ambitious and talented researchers who like to engage in supporting the concept of single patient tailored treatments.

Keywords: personalised genetic medicine,antisense oligonucleotides,severely debilitating or life threatening rare neurological diseases,single patient tailored antisense oligonucleotide treatments
Portable Quantum Sensors for Neurosurgery (PoQus)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Countries involved: Netherlands,France,Germany
Call: Quantum sensing and metrology for market uptake (IA) (HORIZON-CL4-2024-DIGITAL-EMERGING-01-CNECT, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 6151353.75
EU funding (EUR): 4986528.75
Participants: 4
Project status: SIGNED

Modern medical diagnostics heavily rely on optical measurements, especially for real-time analysis of deep tissue, crucial for tasks like post-cancer surgery monitoring where cancer recurrence is a risk due to leftover malignant cells. Current image-guided surgery techniques face limitations in resolution and real-time imaging, posing challenges for completely excising tumors while preserving healthy tissue. Fluorescence lifetime imaging microscopy offers superior depth resolution by measuring the time a fluorophore spends in the excited state before emitting a photon. This technique minimizes errors from environmental factors and photon scattering in tissue but suffers from limited penetration depth. Superconducting nanowire single-photon detectors (SNSPDs) present a solution due to their high performance in longer wavelengths, enabling greater penetration depth. However, current SNSPDs require substantial cooling and are bulky, making them unsuitable for clinical settings. The aim is to develop a portable quantum sensor based on SNSPDs, integrated into a time-resolved fluorescence imaging microscope for use in operating rooms. The prototype will feature a compact cryogenic system for cooling, optimized detectors for efficiency and speed, and software for image analysis. Made of EU components, the system aims for medical-grade quality, enabling real-time analysis of tumor and healthy tissues during surgery, ultimately improving patient outcomes.

Keywords: fluorescence lifetime imaging,image guided surgery,biomedical imaging,medical sensing,superconducting nanowire detectors
HoloBIM-SaaS: Construction 4.0 Software-as-a-Service for Earthquake-Resistant Buildings (HoloBIM-SaaS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Greece
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

HoloBIM-SaaS is a cutting-edge Building Information Modelling (BIM)-based Software as a Service (SaaS) platform for reinforced concrete buildings structural design offering detailed drawings & detaining, material take-offs, and e-Ordering capacity. HoloBIM-SaaS rises up to the challenges of a fragmented AEC market whose digitalisation needs are crucial in the Construction 4.0 era. The platform offers access to an affordable and accessible BIM interoperable software that is able to produce resilient and safe buildings as the demand for earthquake-proof buildings grows. BuildingHOW Team, a female-led venture established in 2017 by prominent scientific and technical members, aims to claim a significant segment of the niche but ever-growing market of reinforced concrete buildings in Europe and internationally estimated at a €4.63B. Through their unique proprietary algorithms for structural analysis we aim at reaching €2.67M 30 months.

Keywords: construction engineering,municipal and structural engineering,smart buildings,smart cities,seismic design,bim,structural analysis,earthquake resistant buildings,saas,composites,patents
Spatial Quantification of Cellular Metabolism in the Tumor Immune Microenvironment (SpatialTMEMetabolism)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1497756.0
EU funding (EUR): 1497756.0
Participants: 1
Project status: SIGNED

The success of cancer immunotherapy, especially immune checkpoint inhibition (ICI), demonstrates the ability of the immune system to fight tumors. However, only a fraction of patients benefit from currently available therapies, and we need to find novel approaches to improve clinical responses. Cellular metabolism has emerged as a key determinant of multiple aspects of immune cell function, especially T cell exhaustion and anti-inflammatory macrophage polarization. However, we currently do not have a good understanding of the metabolic states of human immune cells since no technology has been available to quantify them directly in clinical tumor tissues. I hypothesize that tumors create spatially defined metabolic environments, also called metabolic niches, to suppress immune cells and that this mechanism can be targeted to improve cancer immunotherapy. To test this, we will (1) quantify the metabolic states of immune cells in solid human cancers, (2) identify metabolic immune cell states that predict response to ICI, and (3) reveal the mechanism of metabolic niche formation in tumor organoids. We will quantify cellular metabolism and phenotype directly in human tumor tissues, using the innovative single-cell metabolic profiling (scMEP) approach I have recently developed. We will combine this with multiplexed ion beam imaging (MIBI), a technology that enables 40-dimensional proteomic imaging. MIBI imaging will be complemented by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and machine learning frameworks for the analysis of these multi-omic datasets. Taken together, this project will uncover generalizable concepts of how different tumor entities influence the cellular metabolism of immune cells to modulate their function. The potential therapeutic targets that will emerge from this analysis could thus contribute to improved treatment options for various types of human cancer.

Keywords: immunology,imaging,cellular metabolism
Intelligent power management integrated circuits for a greener, more efficient Internet of Things (NANOPOWER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway,Portugal
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 3552500.0
EU funding (EUR): 2486750.0
Participants: 2
Project status: SIGNED

The Internet of Things (IoT) offers great potential to monitor and manage complex systems, yet remains hindered by excessive use, size, and replacement of batteries in IoT nodes. Decreasing power use is essential to fulfil the IoT promise for smart, sustainable, and green societies. We have developed a unique Intelligent Power-Management Integrated Circuit (IPMIC) using silicon-proven subthreshold technology that can autonomously manage any sensor, microcontroller, wireless chip, or peripheral to reduce energy consumption by ~50-99%. This grants novel capabilities to all designers of battery-powered devices to optimize for increased performance and reduced product size/cost, while eliminating replacement cost/operational barriers for new applications in critical parts of the value chain and environmental impacts of disposal. With EIC support, Nanopower will address the IoT battery bottleneck and become a Europe-based, world-leading ultra-low-power specialist.

Keywords: energy efficiency environmental and green technologies internet of things,embedded pervasive systems network infrastructures micro system engineering semiconductors
Light as a signal for nonchemical cell-to-cell communication in synthetic and biological cell communities (Lighthouse)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 2436875.0
EU funding (EUR): 2436875.0
Participants: 1
Project status: SIGNED

Engineering cell-to-cell communication is fundamental –yet highly challenging– for programming multicellular systems and interfacing living and biomimetic synthetic cells. The problem lies in developing specific communication that is independent of existing chemical signaling and in connecting it to cell behavior. Both the high complexity of intercellular signaling in living cells and the fairly limited capabilities of synthetic cells severely restrict possibilities to engineer communication in and between these two realms. Here, I propose a new nonchemical mode of cell-to-cell communication that operates with light as a signal. I aim to develop sender cells that produce visible light as a signal that corresponding receiver cells respond to. In this light-based communication, the signal will propagate at the speed of light independent of diffusion, will cross optically transparent barriers without the need for membrane transporters, and will allow communication even between physically separated cells. Also, the light signal will be orthogonal of native chemical signals, resulting in high specificity and no cross talk. First, I will establish light-based communication in molecularly defined synthetic cells to decipher the central rules of this new mode of communication. Detailed characterization (light generation, response, distance, dynamics, orthogonality) of light-based communication will provide the framework for later programming of multicellular behavior. Second, I will transplant light-based communication into bacterial and mammalian cells, showing for the first time that communication with light is possible at the cellular level. Last, I will engineer diverse communities of living and synthetic cells with light-based communication showing various behavior, including collaboration, predation, and defense. Ultimately, this will pave the way for an independent, highly modular, nonchemical mode of communication for cellular bionics and cellular bioengineering.

Keywords: synthetic cell,artificial cell,bottom up synthetic biology,optogenetics,photoswitchable proteins,reversible,intercellular communication,light,cell signaling,multicellular communities,biomimetic systems,quorum sensing,orthogonal communication,biohybrids,cellular bionics,bioluminescence,giant unilamellar vesicles,luciferase