Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
STREAM - Sonar Technology for Remote Environmental Monitoring (STREAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: United Kingdom
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Oil and gas is continuously leaking from offshore deepwater infrastructure. Up to 1 million tonnes of oil are lost from deepwater drilling leaks each year, with 601 oil and gas releases reported in the North Sea in 2015 alone, up 14.5% on the previous years. Current leak detection technologies suffer from high false positives, high cost, lack of continuous monitoring and safety risks, meaning the majority of leaks are not detected by equipment. To address this major environmental and economic problem, we have developed STREAM, a unique technology which uses subtle changes in the speed of sound to detect contaminants in seawater. We have recently completed a funded project to technically prove our concept at TRL6. SALT has a proven track record of successfully commercialising highly innovative technologies such as our award-winning SonarBell. We have also successfully led two European collaborative projects to exploit the SonarBell in different applications. Currently, we are in advanced discussions with Statoil and BP who have shown great interest in the STREAM technology. Crucially, we are in negotiations with Subsea7, a global tier 1 service provider, to include STREAM in their service offering. We now need to validate the market opportunity and reduce commercial risk by running large scale trials and optimising our product performance. 5 years post-project, we will generate annual revenues of €31.8 million, €4.7 million in net profits, 282 jobs, representing an 8 x ROI to EC investment. STREAM will significantly reduce the catastrophic impacts of undetected oil and gas leaks on marine ecosystems, fisheries and aquaculture by helping producers effectively detect leaks and meet stricter industry legislation.

Keywords: marine pollution,sonar technology,blue growth,sustainability,leak detection
Skill-For.Action (Skill-For.Action)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Spain,Italy,South Africa,Germany,Spain,Italy,Switzerland,Poland
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 2941521.48
EU funding (EUR): 2941521.48
Participants: 11
Project status: SIGNED

Global environmental and climate changes compromise forest resources in different ways, intensities and at various levels. Drought related losses in growth performance, the increase in intensity and frequency of wild fires and storms, and of biological risks are just a few of the most perceptible effects across the forests in Europe as well worldwide. Global change weakens the efficiency of forest carbon sequestration capacity and thus forestry sector ability to mitigate climate changes in the medium to long-term perspective. An innovative adaptive and integrative forest management plays a key role in driving forests to face the environmental changes and to meet both maintaining high forest carbon sequestration potential and guaranteeing economic efficient and more ecological sound forest operations. ETN Skill-For.Action integrates the fundamental research in forest ecology and applied science of forest engineering. This integration is crucial and innovative to comprehensibly understand carbon dynamics in forests in terms of feedback between carbon sequestrations and release. Overarching objective of ETN Skill-For.Action is to provide high-level training and education in adaptive and integrative forest management under global changes to a new generation of early stage researchers for a successful career in the forest-sector and natural resource management. The education follows an innovative, interdisciplinary and intersectoral approach by a specific and unique combination of applied research and training activities delivered by academic and non-academic partners to strengthen complementary soft skills. ETN Skill-For.Action will support each ESR to successfully implement their individual project through a well defined supervising strategy by merging the educational experience of the academic supervisors with the practical knowledge of the non-academic supervisors.

Keywords: climate change,carbon sequestration,carbon footprint,forestry,risk assessment,portfolio,theory,wood raw material,resource and energy efficiency
Joining forces to exploit the mycobiota of Asia, Africa and Europe for beneficial metabolites and potential biocontrol agents, using -OMICS techniques (MYCOBIOMICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,South Africa,Germany,Thailand,Czechia,Netherlands,Kenya
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-04-01
End date: 2025-09-30
Duration (months): 54.0
Total project cost (EUR): 1375400.0
EU funding (EUR): 1375400.0
Participants: 8
Project status: SIGNED

The proposed project embarks on a previous collaboration in the framework of H2020-MSCA-RISE “GoMyTRi” that has successfully laid the groundwork for an international collaboration involving three worldwide leading research infrastructures from Germany, the Netherlands, and Thailand. The common research interest of the partners is basic and applied mycology, and they joined forces to explore the beneficial secondary metabolites for development of antibiotics, and to find potential candidates for development of environmentally friendly fungal biocontrol agents. The interdisciplinary training conducted in the course of “GoMyTri” has already resulted in several joint scientific publications, and some of the PhD candidates involved have graduated with excellent grades, while some of the postdoctoral researchers involved have gained valuable experience in project management. During the past years, the collaboration has been consolidated and the partners have also been changing the scope of their respective research agendas. The new proposal aims to expand the collaboration by adding further, carefully selected partners from Austria, the Czech Republic, Kenya and South Africa, which have an excellent scientific track record and bring in additional know-how and expertise. The new objectives have been expanded to the implementation of –OMICS technologies and studies on the interaction of fungal organisms in order to discover new bioactive molecules. Furthermore, the project aims at characterization of the mycobiota of important agricultural plants. The scientists involved in the training program will thus be working in an interdisciplinary scenario that is intended to tackle several important global challenges at once and be given the opportunity to learn many important methods and techniques that are essential for studies of beneficial as well as detrimental fungal organisms. In addition, several dissemination events are planned.

Keywords: fungi,antibiotics,biocontrol,chemical ecology,natural product chemistry
Design of Nanomaterials for Targeted Therapies Guided by Super Resolution Imaging (NANOSTORM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain,Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1497588.0
EU funding (EUR): 1321587.02
Participants: 2
Project status: SIGNED

Nanomaterials revolutionized the field of targeted cancer therapies introducing innovative approaches towards the molecular recognition of diseased cells. However, despite the large investments in nanotechnology-based drug delivery the translation into clinical applications is still unsatisfactory and up to date there are no actively-targeted materials approved for clinical use. One of the main reasons is the lack of knowledge about the behaviour of nanostructures in the biological environment that makes the rational design of effective drug delivery carriers extremely challenging. NANOSTORM proposes the use of an innovative optical imaging technique such as super resolution microscopy to visualize and understand the molecular interactions of nanomaterials with their cellular targets in unprecedented detail. We recently reported for the first time the ability of Stochastic Optical Reconstruction Microscopy (STORM) to image self-assembled synthetic materials in vitro with nanometric resolution. NANOSTORM aims to bring this to the next level, using STORM to unveil the structure-activity relations of therapeutic nanomaterials in the biological environment at the single molecule level. The knowledge arising from this investigation will provide novel design principles for the next generation of nanomaterials for targeted therapies. In particular, in the framework of NANOSTORM novel nanomaterials for the targeted treatment of prostate cancer will be synthesized and evaluated. This interdisciplinary research program will advance our understanding of nanostructures for targeted drug delivery and guide the formulation of novel materials for cancer therapy.

Keywords: nanomedicine
Mid- and far-IR optoelectronic devices based on Bose-Einstein condensation (MIR-BOSE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Greece,France,France,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2021-09-30
Duration (months): 57.0
Total project cost (EUR): 3786160.0
EU funding (EUR): 3786160.0
Participants: 9
Project status: CLOSED

Optoelectronic devices typically operate in the weak coupling regime between light and matter, for example in conventional lasers relying on population inversion to achieve optical gain. Recently there has been a surge of interest in quantum systems operating instead in the strong coupling regime, when the coupling strength of the light-matter interaction is so strong that new states – cavity polaritons – are created, that are partially light, partially material excitation. In semiconductors, exciton-polaritons have been the most widely studied type of strongly coupled system. Recently a new phenomenon has been realized exploiting intersubband transitions. The resulting excitations are called intersubband polaritons, and they have two remarkable properties: (i) a bosonic character that is maintained up to high carrier densities since they are not restricted by the Mott transition limit; (ii) large Rabi splittings. Although the scientific community has explored the basic science of intersubband polaritons, their potential for future and innovative optoelectronic devices has been entirely untapped. The MIR-BOSE project will realize this potential, and demonstrate disruptive optoelectronic devices operating in the strong coupling regime between light and matter. We will demonstrate the first bosonic lasers operating in the mid-IR and THz ranges of the electromagnetic spectrum. Laser action here does not rely on population inversion, so we will achieve temperature independent operation and high powers. We will demonstrate a new concept of inverse-Q-switching leading to the generation of high power pulses in the mid-IR, overcoming severe bottlenecks in current technology. Finally, we will demonstrate non-classical/quantum light sources and devices, generating squeezed states of light in the mid-IR/THz spectral range for quantum optics. These new sources will have a major impact on several technologies and applications, being advantageous compared to current solutions.

Keywords: optoelectronics,quantum devices
Innovative strategies to increase engraftment of engineered hematopoietic stem cells and bypass genotoxic conditioning, toward the next-generation gene therapy (IMPROVING-GT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) refers to the transfer of nucleic acids into HSPCs, to either add a new copy of a “healthy” gene or to correct a mutated gene. HSPC-GT is successfully used in clinic to treat patients with hematopoietic malignancies and several inherited diseases of the hematopoietic system. Yet, its current use is accompanied by acute conditioning-related toxicities, which impose a burden on patients and limit its application to the most severe conditions. HSPC-GT requires the following steps: HSPCs are mobilized and harvested from the patient, genetically corrected ex-vivo by gene transfer or gene editing and infused back to the patient, after administration of partial or fully myeloablative conditioning to make space in the bone marrow for the modified cells. Administered HSPCs home to the bone marrow, where they engraft and reconstitute a healthy immune system, theoretically throughout life. However, two major shortcomings undermine the full therapeutic potential of HSPC-GT: (i) a decrease in short- and/or long-term engraftment potential due to the ex vivo manipulation of HSPCs and (ii) a toxicity in the hematopoietic and non-hematopoietic organs related to the conditioning regimens, which are based on cytotoxic drugs. The project IMPROVING-GT proposes to develop innovative schemes to increase engraftment and dodge genotoxic conditioning, which are some of the most coveted but still unaccomplished goals of HSPC-GT. The candidate aims to (1) increase the fitness of genetically modified HSPCs by uncovering new players of engraftment and (2) bypass the toxic conditioning requirement by exploiting enhanced mobilization reagents. IMPROVING-GT will pave the way towards non or milder genotoxic regimens, which should greatly minimize undesirable toxicity of current treatments and ameliorate patients’ outcome. Moreover, it may help broadening applications of HSPC-GT to more diseases, including patients with lower disease burden.

Keywords: gene therapy,hematopoietic stem cells,engraftment,transplantation,conditioning,gene editing,mobilization
Family formation decisions and gender attitudes in crisis times: an international, historical and longitudinal comparison. (FAMilyDECisions)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

During the last decades, Spain has experienced not only an strong decrease on its fertility levels but also a significant delay in its timing to childbearing, so much so that it has been considered one of the countries with the lowest-low and latest-late fertility in the world. This research aims to better understand the reasons behind young adults’ behaviors in family dynamics in a moment where it is possible to approach the impact of the economic crisis from different dimensions of the analysis. An extended scientific literature can be found about family formation dynamics and fertility, especially for European countries and mainly using a quantitative perspective. This mainly qualitative project proposes an innovative methodology to analyze the Spanish case from a three different perspectives of analysis: a cross-country comparison (five countries in 2012), an historical comparison (Spain 1985 vs. 2012) and a longitudinal comparison (Spain, same sample in 2012 and 2017). Furthermore, mixed methods will be applied considering the contextualization of qualitative data with quantitative data from census and surveys as complementary approaches; and the application of quantitative analysis to qualitative data. Main data from Spain in 2012 comes directly from the words of young adults in three different moments of their family formation decisions: i) to start a stable relationship; ii) to become parents; and iii) to expand the family after the first child. Main data consists of eighty (80) in-depth personal interviews already carried out to young adults between 24 and 35 years old, living in the Madrid and Barcelona metropolitan areas, that will be compared with an identical sample in the US, Sweden, Japan and Korea. Historical data comes from an existing comparable study from middle 80’s in Spain and longitudinal data will be obtained after re-interview in 2017 the same sample interviewed in 2012 for Spain.

Keywords: low fertility,family formation,marriage,cohabitation,economic crisis,gender,decisions,attitudes,young adults,spain,personal interviews,mixed methods,comparative analysis,longitudinal
INTELLIGENT VALVE FOR PERSONALIZED SAFETY AIRBAG (I-VALVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

According with the World Health organization(WHO) every year the lives of approximately 1.25 million people are cut short as a result of a road traffic crash. Between 20 and 50 million more people suffer non-fatal injuries, with many incurring a disability as a result of their injury. Automobile airbags have been a critical advance in driver and passenger safety, but they can cause injury or even death if not used properly (special to shorter people and children). The objective of this project is to analyze the market viability of an innovative membrane to be integrated in airbags that has the ability intelligently programmed to customize its occupant protection function to the shock conditions and specific characteristics of the occupant who will protect. It will provide a reduction of the risk of critical injuries and fatal in extreme situations in road accident (a preliminary estimation has been done of (14-16% reduction depending on the type of the crash analysed) and with an insignificant cost of the product. The project is based in a previous national research project (ADAPTA) that was followed by an internal RTD project that concluded with an invention that is protected by the patent (13/878710) There is an ongoing national innovation project to confirm the initial tests and will bring the innovation to a TRL 6 by 2017 We have contacted potential customers and three have already demonstrated their interest in the project outcome, including one of the airbag manufactures market leaders ZF-TRW, an international TIER 1, present in more than 20 countries that is in the path to become the second airbag manufacture in the world . The aim of I-VALVE is to reach 6% of that EU niche market share of front and side airbags (summed the % of MAGOM market share and the penetration of this technology by the products manufactured by other with our license) and achieve a year profit of 5,4 million Euros, three years after the commercialization start.

Keywords: adaptative valve,airbag,passenger safety
NOT A writtEn word but graphic symbols. NOTAE: An evidence-based reconstruction of another written world in pragmatic literacy from Late Antiquity to early medieval Europe. (NOTAE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-07-01
End date: 2024-06-30
Duration (months): 72.0
Total project cost (EUR): 1479625.0
EU funding (EUR): 1479625.0
Participants: 1
Project status: SIGNED

The use of graphic symbols in documentary records from the 4th to the 10th c. has so far received scant attention. ‘Graphic symbols’ are graphic signs (including alphabetical ones) drawn as a visual unit in a written text and representing something other than a word. They therefore broadly cover the semantic spectrum of the Latin ‘notae’ (signs) as opposed to ‘litterae’ (letters of the alphabet). With the gradual introduction of signature and the increasing use of papyrus from the 4th. c., the presence of graphic symbols became widespread in legal documents as it already was in other written records, and continued in post-Roman kingdoms as part of the same historical process of reception of the late antique documentary practice. Drawing symbols had a major social impact, because, provided it was done in one’s own hand, it placed on the same footing professional scribes, basic literates and illiterates. For illiterates, it certainly meant, both in the late Roman state (a Greek-Latin graphic and linguistic community) and in the post-Roman kindgdoms (as long as Latin functioned as language of vertical communication) a way of taking an active part in the writing process. A thorough investigation of this ‘other side’ of the written world can therefore provide precious insights about the spread of literacy as a whole. The available instances of graphic symbols, which number in their thousands, will be investigated in their contemporary context as well as diachronically, bringing together methods developed in the fields of palaeography, diplomatics and history. Archaeology, sociolinguistics, social anthropology and history of christianity will also provide important methodological angles. The census, description and images of these graphic symbols will be made available on the web through the relational and dynamic NOTAE-Database, which will be the main result of the project and, at the same time, the research tool for both the team members and all the interested scholars.

Keywords: diplomatics,juridical papyrology,literacy,graphic symbols