Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Wroclaw Centre of Excellence (WCE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Framework Partnership Agreement
Countries involved: Germany,Germany,Poland,Poland
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-04-29
End date: 2020-04-28
Duration (months): 60.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 4
Project status: CLOSED

The objective of the proposal is to form Wroclaw Centre of Excellence (WCE), by a close collaboration of Wroclaw University of Technology with National Centre for Research and Development, and German partners - Fraunhofer Institute for Material and Beam Technology in Dresden and University of Würzburg, renowned science institutions. The vision of WCE includes innovative technology and device development on the state-of-the-art level, as well as economic activities through interactions with established Polish and European companies and the foundation of new spin-off companies. A special focus will be put on new materials, nanophotonics, additive laser-based technologies and new management organisation systems. Nanophotonics is chosen because it allows a wide variety of novel devices for e.g. sensing or optoelectronic applications. Developed materials allow for producing new products with novel functionalities, very often only possible with additive manufacturing technologies, including laser-assisted processes. Synergy between the nanophotonics and modern manufacturing technologies provides additional opportunities, e.g. for “smart” parts directly manufactured with embedded nanophotonic sensors. The objectives of the proposal will be achieved in two stages, first the detailed and robust Business Plan (BP) will be prepared, based on the expertise of all involved partners. In the second stage, the WCE will be established according to this BP. The Centre will be established in Wroclaw, Poland, eligible for participation in the programme as a low-performing country. The creation of the WCE will significantly enhance the Lower Silesia region in the respective fields of science in order to reach an internationally competitive level in the target areas, reducing research and innovation disparities within the European Union.

Keywords: nanophotonics,additive manufacturing,laser assisted manufacturing,new materials,optoelectronics,sensing
High Throughput Microfluidic Cell and Nanoparticle Handling by Molecular and Thermal Gradient Acoustic Focusing (ABODYFORCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2025-07-31
Duration (months): 69.0
Total project cost (EUR): 1999720.0
EU funding (EUR): 1999720.0
Participants: 1
Project status: SIGNED

In this project we will push the limits of microscale ultrasound-based technology to gain access to diagnostically important rare constituents of blood within minutes from blood draw. To meet the demands for shorter time from sampling to result in healthcare there is an increased interest to shift from heavy centralized lab equipment to point-of-care tests and patient self-testing. Key challenges with point-of-care equipment is to enable simultaneous measurement of many parameters at a reasonable cost and size of equipment. Therefore, microscale technologies that can take in small amounts of blood and output results within minutes are sought for. In addition, the high precision and potential for multi-stage serial processing offered by such microfluidic methods opens up for fast and automated isolation of rare cell populations, such as circulating tumor cells, and controlled high-throughput size fractionation of sub-micron biological particles, such as platelets, pathogens and extracellular vesicles. To achieve effective and fast separation of blood components we will expose blood to acoustic radiation forces in a flow-through format. By exploiting a newly discovered acoustic body force, that stems from local variations the acoustic properties of the cell suspension, we can generate self-organizing configurations of the blood cells. We will tailor and tune the acoustic cell-organization in novel ways by time modulation of the acoustic field, by altering the acoustic properties of the fluid by solute molecules, and by exploiting a novel concept of sound interaction with thermal gradients. The project will render new fundamental knowledge regarding the acoustic properties of single cells and an extensive theoretical framework for the response of cells in any aqueous medium, bounding geometry and sound field, potentially leading to new diagnostic methods.

Keywords: pacs2010 43 25 nm acoustic streaming 43 25 qp radiation pressure 43 40 rj radiation from vibrating structures into fluid media 47 35 rs sound in fluids 43 35 ud thermoacoustics,high temperature acoustics,photoacoustic effect
Bio-LP-1 - A novel technology for water safety and surveillance testing (Bio-LP-1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In Europe, contaminated water, water distribution and premise plumbing systems are a significant source of many of Health Care Associated Infections, and pose a significant threat to human health. Legionaires Disease, which is spread through contaminated water particles, is estimated to cause 180–360 cases per million inhabitants in Europe alone with mortality rates ranging from 10-25%. It is estimated that the global legionella testing market will reach $352.6 million by 2025, with water testing the largest testing type segment in terms of revenue, due to increased water testing activities in various industries as a preventive measure to control infections. Current gold standard tests (bacterial culture-based) used to detect Legionella species are slow and lack sensitivity. These are unsatisfactory, and have many limitations affecting results seen, and have an onward impact on human health. BioProbe Diagnostics (BPD), is a recently established Irish diagnostics company, specialising in the detection of environmental pathogens (http://bioprobedx.com/). We have developed a novel rapid single test kit (Bio-LP-1) to address the current limitations and unmet Legionella testing market needs. Bio-LP-1 allows for the rapid (< 5 hr), quantitative, simultaneous and identification of Legionella species, Legionella pneumophilla and Lp-sg1 in water, allowing for a faster, more accurate, robust test, quickly identifying harmful water samples, with the potential to positively impact on human health. To close the gap from lab to market, BPD seeks to use this feasibility study to accredit Bio-LP-1 to ensure market acceptance. This study will also include a feasibility assessment with respect to product manufacturing and distribution supply chain. Upon completion of this feasibility study, BPD will be in a position to launch their first product to market, while also determining opportunities for company growth and development over the next 3 years.

Keywords: water,public health,legionella,rapid tests
Development and clinical validation of novel smart device to provide real-time ablation + tissue analysis through advanced 4D imaging to enable >90% success rate in Atrial Fibrillation treatment (VERAFEYE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany,Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-10-01
End date: 2023-06-30
Duration (months): 33.0
Total project cost (EUR): 4349717.5
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

OneProjects is a new medical device company based in Dublin and Munich developing the new wave of disruptive cardiac imaging innovations that will provide a sea change in the treatment of atrial fibrillation (AFib) through ablation. With the clinical need at the core of our mission and world-class expertise in medical imaging and product commercialisation, OneProjects is developing VERAFEYE, a novel smart catheter system that provides real-time 4D ablation/tissue analysis and navigation enabled through advanced imaging and analytics. VERAFEYE is a breakthrough connected technology which can generate unprecedented 4D data during the ablation procedure, thus providing the physician with real-time analysis of the surgery. VERAFEYE will for the first time allow clinicians to correct and enhance the treatment in the 1st procedure, ensuring the patient is AFib free, and hence remove the need for multiple surgeries. VERAFEYE will shift treatment to the era of evidence- and data-based success rather than purely relying on the experience of the electrophysiologist as is currently the case.

Keywords: atrial fibrillation,catheter ablation,improved efficacy,4d tissue and ablation analysis,electrophysiology
PLANT RESPONSE to ‘friend or foe’: a CELL type specific nuclear proteomics approach (PlantCellResponse)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Plants respond to and must distinguish between beneficial and pathogenic bacteria (‘friend and foe’) surrounding them. Bacteria may manipulate the plant’s immune system to allow colonialization or can be resistant to plant defence responses such as the biosynthesis of specialized metabolites. It has been increasingly shown that plant responses occur in a cell type specific manner but single cell research has not yet been extensively explored in plant. Here, I propose to apply a state of the art in vivo protein proximity labelling technique to investigate responses to beneficial and pathogenic bacteria in the Arabidopsis thaliana root including the cell type specific level. The first objective of the proposed research is to determine if and to which extent there are differential plant responses to pathogenic and beneficial bacteria with Plant Growth Promoting effects (PGPB), which processes or specialized metabolites are involved in these responses and which regulatory proteins control these responses. This will be achieved through a multi-omics approach for which I will generate nuclear proteome data through protein proximity labelling, RNA-seq and metabolite data from A. thaliana seedlings exposed to a pathogen versus a PGPB. The second objective of this research will be to investigate the response regulation to a PGPB and a pathogen in specific root cell types by generating cell type specific nuclear proteome data. As the third objective I will determine the role of specific regulatory protein candidates from objectives 1 and 2 and their target cell type specific processes such as specialized metabolism or root development through individual gene by gene experiments. The proposed research will provide new insights into how plant responses to ‘friend or foe’ are regulated in different cell types. The generated datasets will be valuable for the community and provide a starting point for my own future independent research career.

Keywords: plant sciences,plant environment interaction,pathogens,plant growth promoting bacteria pgpb,jasmonate,specialized metabolism,transcriptional regulation,transcription factors,nuclear proteomi
A Bidirectional MyoKinetic Implanted Interface for Natural Control of Artificial Limbs (MYKI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2023-02-28
Duration (months): 78.0
Total project cost (EUR): 1475269.0
EU funding (EUR): 1475269.0
Participants: 1
Project status: CLOSED

MYKI aims at developing and clinically evaluating a dexterous hand prosthesis with tactile sensing which is naturally controlled and perceived by the amputee. This will be possible by overcoming the conventional approaches based on recording electrical signals from the peripheral nervous system (nerves or skeletal muscles) through the development of a radically new Human-Machine Interface (HMI) based on magnetic field principles, both able to decode voluntary motor commands and to convey sensory feedback to the individual. Core of this system is a multitude of magnets implanted in independent muscles and external magnetic readers/drivers (MRDs) able to (i) continuously localize the movements of the magnets and, at specific times, (ii) induce subtle movements in specific magnets. In fact, as a magnet is implanted it will travel with the muscle it is located in, and its localization will provide a direct measure of the contraction/elongation of that muscle, which is voluntarily controlled by the central nervous system. In this way it will be possible to decode the efferent signals sent by the brain by observing a by-product of the muscle fibres recruitment. On the other hand, a movement induced in the implanted magnet by the external MRD, could provide a perceivable stimulus, conveyed to the brain by means of the peripheral sensory receptors present in the muscle (e.g. muscle spindles or Golgi tendon organ) or in the neighbouring skin (tactile mechanoreceptors). In this way we aim to provide tactile and/or proprioceptive sensory information to the brain, thus restoring the physiological sensorimotor control loop. Remarkably, with passive magnetic tags (that do not require to be powered-on) and wearable readers/drivers, it will be possible to implement a wireless, bidirectional HMI with dramatically enhanced capabilities with respect to the state of the art interfaces, as illustrated in this proposal.

Keywords: upper limb prosthetics,sensory feedback,natural control of prehension,myokinetic interface,implanted interfaces,magnetic field
AlphaSense Market Penetration and European market Development (AMPED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2015, 2015)
Start date: 2015-09-01
End date: 2016-11-30
Duration (months): 15.0
Total project cost (EUR): 2595503.75
EU funding (EUR): 1816852.63
Participants: 1
Project status: CLOSED

Finnish-based company AlphaSense is the provider of a disruptive Financial Search Engine (FSE) technology used by analysts and portfolio managers at over 275 client firms, including many of the world’s leading investment firms and banks. The company has gained strong adoption particularly with North American investment managers, and now AlphaSense is seeking to expand its service reach in Europe and to adapt and replicate the product for two new market segments. The AlphaSense FSE provides an innovative combination of leading edge language processing technologies yielding major time savings for knowledge professionals, who are currently wasting countless hours browsing through various information sources without effective search tools.
INtegrating Distributed data Infrastructures for Global ExplOitation (INDIGO-DataCloud)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Germany,Spain,Italy,Italy,Germany,Italy,Poland,Switzerland,Croatia,Poland,France,Czechia,Netherlands,Netherlands,United Kingdom,Portugal
Call: Managing, preserving and computing with big research data (H2020-EINFRA-2014-2, 2014)
Start date: 2015-04-01
End date: 2017-09-30
Duration (months): 30.0
Total project cost (EUR): 11565239.0
EU funding (EUR): 11138114.0
Participants: 30
Project status: CLOSED

The INDIGO-DataCloud project (INDIGO for short) aims at developing a data/computing platform targeted at scientific communities, deployable on multiple hardware, and provisioned over hybrid (private or public) e-infrastructures. This platform will be built by leading European developers, resource providers, e-infrastructures and scientific communities in order to ensure its successful exploitation and sustainability. All members of the consortium share the common interest in developing advanced middleware to sustain the deployment of service models and user tools to tackle the challenges of the Big Data era. INDIGO will exploit the formidable know-how that was built in Europe along the past ten years of collaborations on scientific computing based on different consolidated and emerging paradigms (HPC, Grid and Cloud). Regarding Cloud computing, both the public and private sectors are already offering IaaS-type Cloud resources. However, numerous areas are of interest to scientific communities where Cloud computing uptake is currently lacking, especially at the PaaS and SaaS levels. The project therefore aims at developing tools and platforms based on open source solutions addressing scientific challenges in the Cloud computing, storage and network areas. INDIGO will allow application development and execution on Cloud and Grid based infrastructures, as well as on HPC clusters. The project will extend existing PaaS solutions, allowing public and private e-infrastructures, including those provided by EGI, EUDAT, PRACE and HelixNebula, to integrate their existing services, make them available through GEANT-compliant federated and distributed AA policies, guaranteeing transparency and trust in the provisioning of such services. INDIGO will also address the development of a flexible and modular presentation layer connected to the expanded PaaS and SaaS frameworks developed by the project and allowing innovative user experiences, also from mobile appliances.

Keywords: open paas,dynamic resource provisioning,elastic resource provisioning,hybrid cloud computing,cloud storage,cloud virtual networks,scientific portals,scientific workflows
Surviving metabolism: acid handling and signalling (Survive)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-11-30
Duration (months): 78.0
Total project cost (EUR): 1922575.0
EU funding (EUR): 1922575.0
Participants: 1
Project status: SIGNED

Metabolism generates vast quantities of acid, which exerts broad-spectrum biological effects because protein protonation is a powerful post-translational modification. Regulation of intracellular pH (pHi) is therefore a homeostatic priority, but carefully orchestrated proton dynamics are a versatile signal. Extracellular acidity is an established chemical signature of tumours and has recently been proposed to convey a signal that shapes the phenotypic landscape of cancer. Cancer’s genetic instability yields diversity in acid handling and signalling, forming a substrate for selection under acid-stress. This is a plausible mechanism for disease progression and an analogy can be drawn to experimentally-verified hypoxic selection. Current models of acid handling in cancer are, however, based on population-averages of observations made at the cell level. This fails to appreciate diversity and the complexity inherent in tissues. We will produce a more complete understanding of acid handling that accounts for diffusive transport across tissue compartments and the role of the tumour stroma. A systems-approach of characterising pH-regulatory processes cell-by-cell will identify which components are liable to vary, and thus are a substrate for acid-driven somatic evolution. The long-term effects of proton signals on gene expression have not been tested, despite evidence for proton-sensing transcription factors. To address the mechanism for adaptation to acid-stress, proton-sensing transcription factors will be characterised from studies of gene expression under chemically and optogenetically operated pH stimuli. The definition of a cell’s fitness to survive at a particular microenvironment pH and its relationship with stemness remain unclear. Phenotyping pHi-gated subpopulations in terms of growth, stemness and tumourigenicity will define pH-fitness and its role in aggressiveness. In evolving to survive metabolism, cancer cells may acquire the ability to thrive in new niches.

Keywords: proton signaling,proton sensors,ph regulation,metabolism,diffusion,acid,base chemistry,tumour microenvironment,tumour stroma,darwinian selection,acid driven somatic evolution