Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Systems-Level, Multi-layer Understanding of Cellular Responses to Ionizing Radiation (TRIREME)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Israel,United Kingdom,Czechia,Germany,Switzerland
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 3841740.0
EU funding (EUR): 2928426.0
Participants: 5
Project status: CLOSED

The TRIREME project aims at developing and implementing a multidisciplinary strategy for a systems-level analysis of a cornerstone of cellular homeostasis – the DNA damage response (DDR). The DDR is a complex signaling network that is responsible for maintaining the stability and integrity of the cellular genome in the face of DNA damage. DDR defects underlie acute and chronic forms of human ailments that involve tissue degeneration, premature ageing, sensitivity to environmental agents and cancer predisposition. Importantly, many cancer treatment regimens are based on DNA damaging agents. Therefore, gaining systems-level understanding of the DDR is of paramount importance for human health. TRIREME brings together a multidisciplinary consortium of six world-leading researchers with long-standing expertise in the DDR, cell cycle control, functional genomics, proteomics and computational biology. It will focus on a prototypic DNA damage inducer – ionizing radiation (IR), used extensively in cancer radiotherapy. The critical IR-induced DNA lesion is the double strand break, which vigorously activates the DDR. We will systematically analyze the IR-induced network in all its major layers: gene expression, microRNA expression, the proteome, and key protein post-translational modifications. The analysis is aimed at obtaining a global view of the DDR, and identifying new players in the network. The data obtained by these different approaches will be integrated into coherent models using novel computational algorithms developed for TRIREME. To the best of our knowledge, such an analysis has not been applied before to mammalian systems. The results are expected to have far-reaching ramifications in various biomedical fields, with special importance for clinical oncology.

Keywords: dna damage responses,systems biology,signaling networks,functional genomics,proteomics,microrna,ionizing radiation.
Promoting Adolescent health through an intervention aimed at improving the quality of their participation in Physical Activity (PAPA)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,Norway,Spain,France,Greece,Spain,United Kingdom
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-04-01
End date: 2013-09-30
Duration (months): 54.0
Total project cost (EUR): 3785303.2
EU funding (EUR): 2980680.0
Participants: 8
Project status: CLOSED

The background of this project is related to the role of sport in two recent White Papers from the Commission on an integrated EU approach to reducing ill health and enhancing public health, the White Paper on A Strategy for Europe on Nutrition, Overweight and Obesity related health issues and the White Paper on Sport. The project centres on the development and validation of a new method in health promotion, namely a community-based coach education program aimed at promoting the psychosocial development and adoption of healthy lifestyles among young people in Europe. The proposed project will foster collaboration between major research groups representing 5 countries (8 universities) in the European Community and promote the integration of their ongoing research efforts centred on health promotion in youth from two perspectives, namely (a) motivational processes and optimal functioning in the physical domain among young people, and (b) cross-national differences in and environmental impacts on children’s health behaviour. In terms of study design, the PAPA project will examine differences between the provision of youth sport and its health related impacts as currently exists in the targeted countries and a youth sport intervention designed to enhance personal competence, relatedness and self determination of the young players aged 10-14 and their adoption of a healthy lifestyle. In examining the effectiveness of the intervention programme, the pre- and post-season (plus beginning of the subsequent season follow-up) responses of coaches and players in the intervention arm (representing 50 football teams) will be contrasted to a control group of 30 coaches and their players.

Keywords: child and adolescent health behaviour youth sport football coach education
Facilitating Implementation of Research Evidence (FIRE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,United Kingdom,United Kingdom,Ireland,Sweden,Canada,Netherlands
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2013-06-30
Duration (months): 54.0
Total project cost (EUR): 4216244.4
EU funding (EUR): 2999914.0
Participants: 8
Project status: CLOSED

Facilitating Implementation of Research Evidence (FIRE) is a proposed four year programme of research to identify and validate key factors determining the successful implementation of research evidence in practice. The study is underpinned by a conceptual framework, the Promoting Action on Research Implementation in Health Services (PARiHS) framework, which proposes that the successful implementation of research evidence is dependent on the complex interplay of the evidence, the context of implementation and the way the process is facilitated. The planned research will focus on evaluating the feasibility and effectiveness of facilitation as an implementation strategy. A randomised, controlled trial with three intervention arms (standard dissemination and two different models of facilitation) and six units in each of five countries (four in Europe, plus Canada; n=30) is planned. The units will be asked to implement research based guidance on continence promotion and receive differing levels of facilitation support to do so. Detailed contextual, process and outcome data will be collected to fully explore the complex processes at work during implementation. With the combination of an international consortium and experienced research team, a theory-driven, multi-method evaluation study and detailed attention to stakeholder involvement and dissemination throughout the research, the study has the potential to make a significant contribution to the knowledge and practice of translating research evidence at a clinical, organisational and policy level, within Europe and internationally.

Keywords: facilitiation,implementation,evidence,knowledge transfer,knowledge utilisation,continence,guidelines
Malaria Transmission Blocking by Vaccines, Drugs and Immune Mosquitoes: Efficacy Assessment and Targets (TRANSMALARIABLOC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Italy,Greece,France,Burkina Faso,Uganda
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-12-01
End date: 2013-05-31
Duration (months): 54.0
Total project cost (EUR): 3973193.4
EU funding (EUR): 2993964.0
Participants: 7
Project status: CLOSED

Malaria is a complex disease, dependent on multiple host/parasite/vector interactions. This tripartite system offers numerous opportunities for disease-preventing interventions, but also creates robustness that undercuts ‘magic bullet’ expectations. Our interdisciplinary TransMalariaBloc will approach the challenge of malaria control in the field from this perspective. It utilizes the enormous recent advances in our molecular understanding of the three implicated organisms without prejudicing which targets or process will prove most suitable to transmission blocking (TB). In a feedback loop of experimentation and modeling, we will address the potential and actual impact of TB drugs and remedies which supplied to human hosts, can block transmission from an infected bloodmeal; TB vaccines which elicit human antibodies to antigens essential for transmission; and immune mosquitoes, genetically modified (GM) to achieve natural or synthetic refractoriness. Recent studies suggest that vector/parasite genotypic interactions determine the success or failure of Plasmodium falciparum to infect mosquitoes. In this perspective, we will assay genome-wide polymorphisms in both parasites and vectors to dissect important genotype*genotype interactions, thus guiding the development of effective TB vaccines, drugs and remedies, and GM mosquitoes. Effectiveness of TB interventions, especially via use of GM mosquitoes, depends on the balance of infection and resistance costs. Components of this balance will be explored, to foresee the dynamics of vectorial competence in mosquito populations and assess the efficacy of TB strategies, as well as guide the development of new targets. Again, interaction between modeling and experimentation will be a powerful combination. This proposal represents an ambitious, but feasible approach, spanning from molecular to population and environmental levels, to optimizing TB interventions for malaria control in endemic areas.

Keywords: anopheles,plasmodium,interactions,evolution,modelling,infection,immunity,disease,vector,parasite
Molecular Networks of Dopaminergic Neurons in Chordates (DOPAMINET)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Italy,Japan,France,Germany,United Kingdom,Germany,Sweden,United Kingdom
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-02-01
End date: 2012-07-31
Duration (months): 42.0
Total project cost (EUR): 3831030.0
EU funding (EUR): 2967180.0
Participants: 10
Project status: CLOSED

Background. Parkinson Disease is the second most common progressive neurodegenerative disorder. The selective degeneration of subsets of midbrain dopaminergic neurons is believed to be the primary cause for disruption of the ability to control movements. Objective. We propose to apply a highly interdisciplinary approach to construct complex networks consisting of protein coding genes, non-protein-coding genes and cis-regulatory elements within dopaminergic neurons in the brain across three chordate organisms (Mouse, Zebrafish and Ciona) to identify and compare gene regulatory networks in these neurons. This will be achieved by: • Expression profiling of genes on single dopaminergic neurons via laser microdissection and transgenic lines in Mouse, Ciona and Zebrafish • HT-Sequencing of microCAGE assays on dopaminergic neurons, providing TSS usage and transcript discovery • Microscopy HTS of cis-regulatory elements • siRNA and morpholino network perturbation experiments • Innovative systems biology approaches to decipher and define molecular networks Data generated by microCAGE and microarray will define a set of key genes in dopaminergic neurons, in which cis-regulatory elements will be predicted and screened utilizing HTS in zebrafish. The data will aid network reconstruction, which will be validated by perturbation experiments. This project relies also on the availability of data produced through the many existing collaborations among consortium partners such as FP6 funded TRANSCODE project as well as the international Fantom3 consortium. Potential impact: The prevalence of PD in Europe today is ~2 million people. Within the next 50 years, the number is expected to rise to 5 million. Thus, the burden placed by dementia on the working-age population will rise dramatically. No treatments are known to slow the progression of the disease. Deciphering the basic networks of dopaminergic neurons will generate novel diagnostic and therapeutic candidates.

Keywords: transcriptome,zebrafish,ciona,dopamine,parkinson,high throughput,gene network,gene discovery,system biology,enhancers,cis-regulatory elements
INSIGHT into issues of Permanent Access to the Records of Science in Europe (PARSE.INSIGHT)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: United Kingdom,Netherlands,Germany,Germany,France,Germany,Switzerland,Germany
Call:  (FP7-INFRASTRUCTURES-2007-2, 2007)
Start date: 2008-03-01
End date: 2010-02-28
Duration (months): 28.0
Total project cost (EUR): 1797716.0
EU funding (EUR): 1250000.0
Participants: 9
Project status: CLOSED

The FP7 e-Infrastructures initiative has already resulted in a number of projects being set-up or in negotiation covering a range of areas of scientific endeavour. The creation of virtual research communities brings together stakeholders with diverse backgrounds and capabilities. One consequence is a large diversity of approaches and there is as yet little consensus across these communities about best practices in maintaining permanent access to the records of science in a sustainable way. The purpose of this proposal is to work with providers and users of scientific information and repositories to deliver insight into the issues of sustainable permanent access and provide cross-fertilisation of ideas and requirements between providers and users, between the various sectors of interest they represent and between the research community as a whole and national/European funding agencies. There will be six key outcomes for the EU – it will provide: • a roadmap for the support e-infrastructure for long-term accessibility and usability of scientific and other digital information in Europe. • insight into current and planned research and development relating to e-infrastructures and permanent access, national, European and global, regardless of the funding mechanism • identification of gaps in the existing and planned infrastructure and the research agenda • the ability to share and capitalise on best practices as well as understanding the impact that e-Science is having on the research communities that it is serving, through an insight study into the capabilities and practices within the various research communities • better-informed investment decisions and sustainable e-repositories through an impact analysis framework and tool based on these insights • an international process for evaluating the sustainability and trustworthiness of digital repositories, and identifying best practice

Keywords: e-infrastructures,curation,preservation
Mobilising and Integrating Communities on Grid Standards and Best Practices Globally (OGF-EUROPE)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Spain,Austria,United Kingdom,Spain,Italy,Poland,France,Germany,United Kingdom,United Kingdom
Call:  (FP7-INFRASTRUCTURES-2007-2, 2007)
Start date: 2008-02-01
End date: 2010-01-31
Duration (months): 26.0
Total project cost (EUR): 1792445.0
EU funding (EUR): 1240000.0
Participants: 11
Project status: CLOSED

The goal of OGF-EUROPE is to stimulate, co-ordinate and harmonise networked actions on Grid adoption across Europe and globally through reinforcement of the Open Standards message and thus capillary diffusion of the Open Grid Forum (OGF) model to Europe in alignment with OGF mission, strategy and leadership. OGF-EUROPE aims to mobilise the Grid European community of researchers, developers, providers, and end-users in both the public and private sector, focusing on issues that are of prime importance within the EU, ultimately increasing the ability of industry and commerce to influence requirements for a more competitive ICT infrastructure towards i2010. OGF-EUROPE scope is pursued by providing a sound, cohese message regarding EU requirements and global priorities in the field, as well as continuing to shape the broad vision while supporting practical progress on maturing and standardising the technology based on real-world experience. OGF-EUROPE is proposed at a crucial time as it provides the opportunity to capitalise on significant European investments performed in the past 8 years, by executing support actions that target the essence of mobilisation and integration of grid communities and that deliver actionable and sustainable results. The OGF-EUROPE Consortium has the necessary expertise, knowledge and skills to demonstrate how grid infrastructures are a competitive advantage in Europe. The co-ordinating organisation – the European Chapter of OGF – brings to the Project the additional asset of its already formalised, operational linkages and influential position within OGF global. Major tangible results of the OGF-EUROPE initiative comprise: 3 reports supporting OGF Technical and Strategic Roadmap, 2 survey reports on trends and Grid practices, 4 workshops on challenges on standardisation issues, 4 Grid adoption challenge reports; 6 Community outreach seminars including 4 in-depth tutorials, 6 Community best practice reports, 2 OGF-EUROPE international ev

Keywords: global adoption,open standards,grid community creation
Theory of Gamma-Ray Bursts and relativistic collisionless shocks (GRB THEORY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Gamma-ray bursts (GRBs) are the most violent of the known cosmic explosions. They are bright enough to outshine the rest of the gamma-ray universe and can be seen out to the distance of the first generation of stars. The burst of gamma-rays that marks the GRB, which last seconds, is followed by an afterglow - a long-lasting X-ray, optical, and radio emission. GRB exploration was very active during the last two decades, mostly thanks to a continuous observational effort. The theoretical analysis of the observations leads to the understanding that the sources of the prompt and afterglow emission are relativistic jets which are powered by a compact engine. Today we know about two different types of GRBs – long GRBs which are generated by the collapse of a young massive star and short GRBs for which the origin is not confirmed yet. Future planed observing missions (e.g., GLAST) promise that GRBs will remain a focus of astrophysical research in the coming years. As a member of the astrophysics research group in the Tel-Aviv University I plan to address two key topics that I consider as crucial in the way to reveal the physics of GRBs. The first is the physics of relativistic collisionless shocks in unmagnetized plasma and in particular the magnetic field generation in such shocks, as inferred from the observations. In addition for its fundamental physical interest, understanding this topic is a necessary ingredient in order to properly interpret GRB observations. The second topic that I will study is the origin of short GRBs. This is one of the most tantalizing open questions today in high energy astrophysics and its resolution may bear direct implications to the search for gravitational waves. My research objectives will be achieved by a combination of analytical and numerical research, leveraging on the experience I gained during my research in Caltech and the long standing collaborations with theoreticians and observers that I developed while researching in the US.

Keywords: theoretical astrophysics,gamma-ray bursts,relativistic collisionless shocks
Automatic Hardware Generation Using the Stream Programming Paradigm (ESL_STR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-11-10
End date: 2012-11-09
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Electronic System Level (ESL) design is an emerging semiconductor design and verification methodology that focuses on higher levels of abstraction to describe the functionality of a platform system. Elevating the abstraction level closer to the application and away from the implementation details is becoming a vital step for rapid prototyping and productization of complex System on Chips (SoCs). The main promise of the ESL methodology is to enable the developers to focus on the important aspects of their application, and to open up platform design to software and algorithm developers that do not necessarily have hardware and architectural expertise. Unfortunately, the ESL vision remains unfulfilled mainly due to the lack of an acceptable abstraction layer among the researchers and the potential users of ESL tools. The lack of such a common language creates a lack of understanding between designers at different levels, unnecessary replication of tasks, potential for erroneous system functionality, and market fragmentation. We believe that a successful ESL abstraction should provide semantics to express “spatial computation” and should share a lot of common elements with parallel programming for multi-core or many-core engines. In this work, we introduce the stream programming paradigm as an ESL abstraction, and we propose the design and implementation of an ESL tool that generates synthesizable hardware based on this paradigm. The streaming programming paradigm is an emerging embedded domain in which an application can be viewed as a collection of independent kernel computations that communicate over explicit data channels.

Keywords: computer engineering,automation,hardware,esl,streaming programming model,compilers,reconfigurable systems,fpga
Establishment of microsystems training requirements in Europe (EUROTRAINING-MST)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Coordination and support actions
Countries involved: Switzerland,Italy,Hungary,France,Denmark
Call:  (FP7-ICT-2007-2, 2007)
Start date: 2008-06-01
End date: 2010-11-30
Duration (months): 30.0
Total project cost (EUR): 499957.0
EU funding (EUR): 499953.0
Participants: 5
Project status: CLOSED

The objective of the EuroTraining-MST proposal is to provide a European Training Infrastructure facilitating the provision of high calibre training across Europe. The structure will support professional advancement training as well as academic training. Professional course providers will get a central place for the presentation of their training offer while academics will get a course material exchange service targeting graduate nanoelectronics schools.

Keywords: training,micro/nanosystems,graduate schools,professional advancement