Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DEVELOPMENT AND ENHANCEMENT OF A STEERING FEEL MODEL FOR SUPER LIGHTWEIGHT STEER-BY-WIRE VEHICLES (STEERINGFEELSBW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2016-01-31
Duration (months): 42.0
Total project cost (EUR): 87500.0
EU funding (EUR): 87500.0
Participants: 1
Project status: CLOSED

The overall aim of this research is the development of a force-feedback model for the steering system of super lightweight Steer-By-Wire (SBW) vehicles. The immediate goals are to explore the role of force-feedback (a.k.a., steering feel) transmitted from the front wheels to the handwheel in road vehicles and, connectedly, to emulate and enhance the steering feel in SBW systems. More specifically, the goals are to (a) perform various driving experiments in an SBW test rig to collect input/output data from/to steering system and vehicle dynamics, (b) investigate the role of force-feedback in super lightweight vehicles so that a mathematical model for generating a proper steering feel in an SBW system can be developed, (c) investigate the cooperation of other information, which is obtained from the vehicle dynamics, with the designed steering feel model with regard to driving performance and thus enhance the steering feel, and (d) develop a steering feel model specific to a driver, through a learning algorithm, for more comfortable steering.

Keywords: technological sciences,mechanical engineering,vehicle engineering,steer-by-wire,steering feel,force-feedback,virtual reality,super lightweight vehicle,man-machine interaction
Infrastructures for Community-Based Data Management (COMDATA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2014-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Structured data is increasingly created, transmitted, and archived across the Web. One of the most important movements in this context, the Linked Data movement, promulgates the rapid online publication of large-scale structured data following three basic principles: i) the creation of a Unique Resource Identifier (URI) for each resource published, ii) the publication of structured data at the URI corresponding to the the resource, and iii) the inclusion of links relating each resource to similar online resources. Publication of Linked Data in various formalisms is currently booming on the Web, fostered by important governmental agencies, social networks, and scientists from various domains. Unrelated communities of users are increasingly interested in querying, manipulating, and arbitrary combining Linked Data in the large to create new applications. Unfortunately, the current data infrastructures at their disposal only provide very limited and rather inefficient support to their needs. The present proposal focuses on designing new distributed data management infrastructures to promote distributed, community-based manipulations of such heterogenous and interlinked data in the large. Two related research problems are tackled. The first problem revolves around the design and implementation of an efficient storage platform to represent, query, and distribute very large amounts of Linked Data. The second problem focuses on new abstraction mechanisms to integrate Linked Data sets a posteriori once they have already been published. The rest of this document defines the main research challenges to be tackled in this context, and outlines a research agenda to realize this vision. It follows the structure suggested in the Work Programme to describe a Career Reintegration Grant proposal.

Keywords: technological sciences,computer engineering,open linked data,data storage,data integration,data abstractions
Homeostatic regulation of mesenchymal stem cells in the haematopoietic stem-cell niche (MSC-HSC NICHE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The cells forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear. Our recent studies have demonstrated that mesenchymal stem cells (MSC) identified using expression of the intermediate filament protein nestin constitute an essential HSC niche component. Nestin+ cells contribute to bone formation, contain all the mesenchymal activity and can self-renew and expand in serial transplantations. Nestin+ MSC are spatially associated with HSC and fibres from the sympathetic nervous system, and highly express HSC maintenance genes. These genes and others triggering nestin+ MSC differentiation are selectively downregulated during enforced HSC mobilisation or β3-adrenoceptor activation. Parathormone treatment doubles bone marrow nestin+ cells and favours their osteoblastic differentiation. In contrast, in vivo nestin+ MSC depletion rapidly mobilises HSC from the bone marrow to extramedullary sites. Purified HSC rapidly home near nestin+ MSC in the bone marrow of lethally irradiated mice, whereas in vivo nestin+ MSC depletion significantly reduces bone marrow homing of haematopoietic progenitors. These results uncover an unprecedented partnership between two distinct somatic stem cell types and argue for a unique niche in the bone marrow. Nestin+ MSC sharing some properties with the ones previously characterised in post-natal bone marrow are present in the foetal liver. In this proposal, we will characterise specific functions nestin+ cells in the adult HSC niche, and will analyse the role of nestin+ MSC during developmental HSC migration. We will also study the homeostatic regulation of the bone marrow stem-cell niche by analysing the role of autonomic and hormonal signals on the proliferation and fate of MSC and HSC. These studies will offer insight into the homeostatic regulation of a somatic stem-cell niche and uncover potential therapeutic targets to stimulate skeletal regeneration and HSC homing, engraftment and mobilisation.

Keywords: haematopoietic stem cells,mesenchymal stem cells,microenvironment,parasympathetic,sympathetic,endocrine,growth hormone,nestin,mobilisation,engraftment,traffic,stem-cell niche,homing
Extreme Returns and Expected Returns in International Stock Markets (EXTRETEXPRET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This proposal is related to the relationship between extreme returns and expected returns for international stock markets. For the first part, I will focus on the minimum daily return on the aggregate market over various historical time windows. The negative of this variable can be interpreted as a measure of Value at Risk and a significantly positive relation between this measure and expected market returns will provide evidence for the importance of downside risk in determining index returns. Fixed-effects panel regressions will be used to test for the proposed linkage controlling for a set of relevant variables. For the second part, I will focus on the maximum daily return for individual stocks over various historical time windows. The under-diversification of investment portfolios and the preference of investors for lottery-like stocks suggest that there should be a significant relationship between historical maximum returns and expected returns at the firm-level. Finding a significantly negative relation will also provide support for behavioral theories related to investor psychology. In this part, univariate and bivariate portfolio analysis as well as firm-level cross-sectional regressions will be employed. The main data source for this project is DataStream. The proposed analyses will be carried out separately for 52 financial markets with an eye on the differences between developed and emerging countries. The results will have potential implications related to international risk management and portfolio allocation, especially in the aftermath of the financial crisis of 2008.

Keywords: extreme returns,time-series return predictability,cross-sectional return predictability,downside risk,value at risk,mean reversion,skewness preference,international equity markets
Endocannabinoid signaling in heart failure: functional relevance of microRNAs (ENSIG-MIRNA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-08-01
End date: 2014-07-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Heart failure is a primary cause of cardiovascular morbidity and mortality with raising economic burden. There is an increasing need for innovative novel therapies. MicroRNAs are novel regulators of gene expression and are implicated in cardiac development and pathologies including heart failure. Research is underway to explore the potential of microRNA-based therapeutics. However many basic research and clinical questions remain to be solved. Dysregulation of endocannabinoid signaling has been recently described in various diseases, including heart failure. Tissue injury induces increase of endocannabinoids which, in turn is pro-apoptotic, pro-fibrogenic, promote oxidati stress and cell death. Inhibitors of the cannabinoid CB1 receptor has been proven to be vasculo- and cardioprotective. Given that microRNAs can regulate global gene networks at the translational level, it is plausible that changes in the level of bioactive molecules, such as endocannabinoid in the failing heart are associated with altered activity of specific sets of microRNA-targets. To date, the effect of endogenous or pharmacological modulators of the endocannabinoid system on cardiac microRNA expression and the potential therapeutic consequences have not been explored. The overall goals of this proposal are 1) to determine the contribution of tissue injury induced endocannabinoid activation on the cardiac microRNA expression profile that is associated with the development of heart failure, 2) to identify functionally relevant microRNAs that are sensitive to the modulation of endocannabinoid signaling and 3) to explore the therapeutic potential of the identified endocannabinoid-regulated microRNAs in heart failure development. The proposed experiments will elucidate how endocannabinoid signaling alters sets of cardiac disease-regulated microRNAs and identify endocannabinoid-sensitive miRNAs relevant for future development of microRNA-based therapeutic approaches in the treatment of heart failure

Keywords: health sciences,heart failure,microrna,myocardial infarct,cardiac function,endocannabinoids
Exploring the interface between cell metabolism and gene regulation: from mRNA interactomes to "REM Networks" (REM NETWORKS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-04-01
End date: 2017-03-31
Duration (months): 60.0
Total project cost (EUR): 2494185.6
EU funding (EUR): 2494185.6
Participants: 1
Project status: CLOSED

The question of how (intermediary) metabolism and the regulation of gene expression are inter-connected represents one of the central challenges for the next decade of research. This proposal aims to take a decisive stab at this question, exploiting hidden gems from the literature and modern day technologies. Some metabolic enzymes have been caught “moonlighting” as RNA-binding proteins and, intriguingly, their RNA-binding activities appear to be under the control of metabolites and/or cofactors of these enzymes. Moonlighting enzymes could thus act as metabolite-controlled RNA regulators in RNA-enzyme-metabolite, or “REM” networks, imposing post-transcriptional influence on gene expression in metabolite-dependent ways. The riboswitches found in bacteria offer a precedent for how metabolites can have a direct effect on RNA metabolism. Within this proposal, we describe how we plan to uncover “all” the mRNA-binding proteins (the mRNA interactomes) of eukaryotic cells in vivo, a feat which would have been impossible until recently. Following the determination of the mRNA interactomes of yeast and three strategically chosen mammalian cell lines, we will focus our follow-up analyses on the RNA-binding enzymes of intermediary metabolism of these interactomes: decipher their bound RNA targets, learn how different metabolic states and metabolites affect the RNA-enzyme interactions and, most importantly, establish the physiological importance of the studied REM networks. The determination of mRNA interactomes will generate an unprecedented resource for the RNA biology community. We undertake this work with the motivation to uncover a key principle of how metabolism and gene expression may be connected, opening a new field of investigation for different disciplines in biomedical research, and unveiling a level of cellular regulation that would have broad implications for our understanding of basic biology and disease.
EUROPEANISATION OF PUBLIC DEBATES AND CIVIL SOCIETY IN TURKEY (EUROCIV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This research project, introducing a novel conceptual framework to Europeanisation studies, is designed to explore the impact of the EU and other institutions, norms and policies of European integration on the politically mobilised civil society in Turkey. By the impact of Europe on civil society organizations (CSOs), we both mean the impact of the EU-induced legislative engineering (EU-isation) on the development of civic/political rights; and the usage of European norms, policies and institutions (Europeanisation) by CSOs a) to develop their organisational structure and effectiveness, and b) to frame and justify their deliberative positions. This research focuses on the CSOs that are actively involved in the debates concerning the rising political Islam and Kurdish identity claims in Turkey. We investigate how and in what ways the EU-required legal and constitutional reforms (EU-isation) on the freedom of association and assembly have affected the political/structural conditions in which CSOs operate in Turkey. Secondly, we explore how the CSOs react to and make use of the EU/European context (Europeanisation) to increase their influence and to promote their political agenda. Another empirical goal of the research is to map out the variety of discourses concerning the EU and Europe disseminated by the CSOs in Turkey. At the theoretical level, on the bases of critical engagement with the concept of Europeanisation, we aim to develop a new analytical framework to Europeanisation studies. Analytically, we develop a clear distinction between EU-isation as a domestic process of legislative, institutional and policy engineering aiming at alignment with EU’s body of law and institutions, and Europeanisation as a wider socio-political and normative context.

Keywords: social sciences,social change,civil society,europeanisation,eu-isation,political islam,secularism,kurdish question,turkey,involving society
Mechanisms of MTOC guidance and Genetic Transfer at the Immune Synapse: novel modes of Immuno-modulation. (GENTRIS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Spain
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-02-01
End date: 2018-01-31
Duration (months): 72.0
Total project cost (EUR): 2011200.0
EU funding (EUR): 2011200.0
Participants: 2
Project status: CLOSED

Cell-cell synapses are an exquisitely evolved means of communication between cells. During the formation of the immune synapse (IS), diverse transmembrane and membrane associated molecules are reorganized into a highly segregated structure at the T cell–Antigen-Presenting Cell (APC) contact site. As part of this process, the tubulin cytoskeleton is vectorially directed toward the center of the IS, where the microtubule-organizing center (MTOC) localizes. MTOC translocation is an early event in IS formation that brings the secretory apparatus into close apposition with the APC, thus providing the basis for polarized secretion. The proposal aims to define how the MTOC controls cytoskeletal rearrangement and communication at the IS, as a mechanism for macromolecule transport and nucleation of signalling molecules during synaptic contact. We will study the mechanisms of MTOC-mediated polarization of multivesicular bodies (MVB) and exosome delivery during IS formation, and will assess the role in these processes of MTOC translocation regulators (HDAC6) and microtubule (MT) polymerization promoters (Plk1 and EB1). MTOC-dependent mitochondrial polarization to the IS will be assessed as a bioenergetic source for cytoskeletal rearrangements, IS maturation and polarized exosomal delivery. In particular, our proposed study of the possible horizontal transfer of miRNAs during cognate interactions between immune cells has the potential to reveal how miRNAs can control the early initiation of immunity. We will investigate the mechanism of directional transfer of RNA-harbouring exosomes at the IS from T cell to APC, and will examine the functional consequences of this transfer on APC biology and on the immune response. These studies will open avenues for the treatment of immune-related diseases.

Keywords: mtoc,immune synapse,t lymphocytes,mirna,exosomes,t-apc interaction
The mechanism by which cohesin controls gene expression (COHESIN CONTROL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: United Kingdom
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-05-01
End date: 2018-04-30
Duration (months): 72.0
Total project cost (EUR): 2421212.0
EU funding (EUR): 2421212.0
Participants: 1
Project status: CLOSED

How cells retain, lose, and regain developmental plasticity is poorly understood due to ignorance of the molecular mechanisms regulating gene expression. Each gene is regulated by a unique set of factors and as a consequence the trans-acting factors and cis-acting chromatin modification states regulating a given gene are extremely rare. Transcription is affected by events taking place many thousands of base pairs away from the start, a property enabling developmental and evolutionary plasticity, presumably made possible by DNA looping or translocation of factors along chromatin. Most factors regulating a given gene function at many other genes, complicating interpretation of the consequences of altering the activity of such factors. It is difficult to exclude the possibility that phenotypes are knock-on effects. This could be surmounted if it were possible to observe individual genes in real time in three-dimensional space and to analyse the immediate consequences of altering the activity of regulatory factors. Of these, those capable of inter-connecting DNAs or of translocating large distances along chromatin are of interest. Cohesin is such a factor, composed of three core subunits, a pair of Smc proteins and a kleisin subunit, that interact with each other to form a huge tripartite ring, within which it is thought chromatin fibres are entrapped. In proliferating cells, cohesin’s primary function is to connect sister chromatids during DNA replication until the onset of anaphase, possibly by virtue of co-entrapment within a single ring. However, cohesin is present in most quiescent cells and it is becoming clear that it also regulates gene expression and recombination. This proposal has two goals: To image gene expression on polytene chromosomes and to investigate cohesin’s role during ecdysone-induced transcription. The advantage of this system is that we can use micro-injection of TEV protease to inactivate cohesin. A second goal is to develop the TEV system to

Keywords: cohesin,sister chromatid cohesion,drosophila melanogaster,ecdysone,es cells,split tev,live cell imaging