Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Technologies for Advanced LIthium-Sulfur batteries toward Safe and Sustainable Mobility Applications (TALISSMAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Spain,France,Germany,Italy
Call: Post-Li-ion technologies and relevant manufacturing techniques for mobility applications (Generation 5) (Batt4EU Partnership) (HORIZON-CL5-2024-D2-02, 2024)
Start date: 2025-07-01
End date: 2029-06-30
Duration (months): 48.0
Total project cost (EUR): 4998873.75
EU funding (EUR): 4998873.75
Participants: 9
Project status: SIGNED

The BATT4EU Partnership's SRIA emphasizes the urgent need for investment in long-term research on Generation 5 (Gen5) battery solutions to overcome the limitations of Li-ion technology and strengthen the EU's industrial autonomy. TALISSMAN’s primary objective is to lead the development of safe, sustainable, high-performance, and cost-effective Gen5 lithium-sulfur batteries (LSBs) for aerospace and other electromobility applications. By bringing together a multidisciplinary consortium of research institutions and top-tier industry leaders, TALISSMAN will develop and demonstrate two advanced battery pathways in small-scale, multi-layer pouch cell format (TRL4): (i) a hybrid quasi-solid gelled concept (Gen2027) and (ii) an all-solid-state sulfide approach (Gen2030). TALISSMAN will tackle critical challenges hindering LSB industrialization, such as polysulfide shuttling and stabilizing the lithium metal anode/electrolyte interface. These efforts will involve developing optimized materials and components, improving cell design and assembly, and refining manufacturing techniques to ensure compatibility and easy integration with existing Gen3 LIB production lines. Iterative feedback loops will optimize the technology’s techno-economic performance, while advanced characterization techniques and novel modelling approaches will enhance the understanding of reaction mechanisms, performance limitations, and degradation processes. The project will incorporate a Safe and Sustainable-by-Design framework, including essential safety and environmental criteria, and promote efficient resource use through life-cycle assessments, eco-design principles, and innovative recycling processes. Lastly, dissemination, exploitation, and communication activities, rooted in an Open Science approach, will support the project, facilitating the future industrial deployment of TALISSMAN's solutions, and contributing to the establishment of a competitive and sustainable battery industry in Europe.

Keywords: solid state battery,li s battery,gen5,3d lithium metal anode,electromobility,hybrid gel electrolyte,sulfide solid electrolyte membrane,safe and sustainable by design
The extracellular matrix as a mediator of cell-cell communication in cardiovascular inflammation (MATRICARD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1495750.0
EU funding (EUR): 1495750.0
Participants: 2
Project status: SIGNED

Cardiovascular diseases, as coronary artery disease (CAD) and its sequelae myocardial infarction (MI) and heart failure, represent the leading cause of morbidity and mortality in industrialized and developing countries. Atherosclerosis is the pathology causing CAD and MI; both are characterized by a sterile inflammation with a chronic and acute course of the disease, respectively. There is a plethora of cell types, as leukocytes, endothelial cells, vascular smooth muscle cells, platelets, fibroblasts, and cardiomyocytes, which play important roles in the initiation, propagation, and termination of the pathophysiological processes. Recent data from genetic studies found that genetic variation influencing extracellular matrix (ECM) proteins is associated with cardiovascular diseases. We found that such proteins which are secreted by one cell type influence phenotypes of other cell types via, e.g., silencing of inflammatory functions or modulation of ECM composition. The ECM hence not only represents a meshwork in which cells are organized but also a communication hub to transduce mechanical stimuli and cell-cell-interaction signals. Here, we aim to explore the ECM proteome in sterile inflammatory diseases as atherosclerosis and MI in an unprecedented depth. We aim to identify novel regulators which give insights into the underlying processes and we will study the molecular and cellular mechanisms modifying the course of the disease. This will lead to the identification of novel therapeutic targets which might reshape our understanding of how these diseases occur and how we can prevent them, and to the development of novel, individualized treatment strategies. Finally, we aim to translate our findings to humans to get first insights on whether these strategies can be adapted and used in clinical trials. MATRICARD will go beyond technical boundaries and lead to a deep knowledge of ECM-mediated cell-cell-communication and reveal its translational potential.

Keywords: coronary artery disease myocardial infarction extracellular matrix cardiovascular inflammation
Demonstrating the first of its kind circular and decarbonised desalination technology to enable wide deployment and transformation of the desalination sector by 2030 (SEA-MINING)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

SEALEAU offers a disruptive deep-tech solution to the seawater desalination market by transforming the current linear destination regime into sustainable circular and decarbonised practices. Building on the technological breakthrough that has been developed by the Founder of the company within his PhD, and further developed through the 5 EU projects that the company has originated, SEALEAU is perfectly positioned to capitalise on our high impact innovation with the potential to create the new market of Circular Desalination. Since 2017, SEALEAU has not only achieved a TRL of 7 for the Circular Desalination technology, but also to create the conditions for its market implementation. Under the leadership of SEALEAU a wide range of technology suppliers have joined forces to provide customised solutions according to different needs of our customers. Through our 3 key products of "Decarbonised Desalination", "Advanced Decarbonised Desalination" and "Decarbonised & Circular Desalination", we are serving different needs for our customers, with a carefully designed and impactful Go-2-market strategy deployed in 3 stages. With 21 Letters of Intent (LOIs) signed already, a large pipeline of commercial projects has been established, ready to be monetised after demonstration of our Circular Desalination demo within this EIC Accelerator project. Our LOIs cover all 3 commercialisation phases of our Go-2-market strategy, with a broad geographical coverage including Cyprus, Italy, Greece, Saudi Arabia, Portugal, Malta etc Our beachhead market comprises island communities that are currently dependent on desalination and are seeking for a sustainable solution that can secure water supply, while minimising environmental impacts. As islands comprise remote areas, mining resources from seawater (desalination brines) can secure access to indispensable raw materials (such as chemicals) as well as stimulate significant local job opportunities through our Circular Desalination solution.

Keywords: desalination circular economy
Sustainability And Resilience for Infrastructure and Logistics networks (SARIL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Norway,Poland,Portugal,Belgium,Austria
Call: New concepts and approaches for resilient and green freight transport and logistics networks against disruptive events (including pandemics) (HORIZON-CL5-2022-D6-02, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 3980007.5
EU funding (EUR): 3980007.5
Participants: 15
Project status: SIGNED

Due to globalized supply chains and the prevalence of just-in-time production, all economies of the industrialized world are reliant on the flawless operation of the logistical network. During the Cov19 pandemic it became apparent that this network can be massively shattered and that a better understanding of its robustness, risks and vulnerabilities is of vital importance. Additionally, it is obvious that the accelerating climate change demands a much greener fright transport. SARIL aims to complement the classic definition of resilience, which focuses on threat prevention, robustness and system recovery, by green aspects. Key performance indicators will be defined which quantify both, the system resistance against disruptions as well as the environmental burden of freight transport. Adopting three different scenarios on different geographical scales (regional, national and international/EU), models will be developed which are able to capture the unperturbed system operation as well as the behavior in case of a disruptions. While the regional (Italy) and national (Spain/Portugal) scenarios focus on natural hazards which become more threatening due to climate change, the international scenario (Northern/Central Europe) considers the disruptions due to pandemics (like Cov19) or wars (like the Russian war against Ukraine). Although the three scenarios will be modelled with varying levels of detail, SARIL aims at a universal understanding of green resilience by using a common framework. The results for the three scenarios will be used to assess similarities and differences between the three geographical scales. By exploiting the findings, recommendations to improve the classic resilience, like e.g., synchro-modal approaches, will be derived. Additionally, SARIL aims for recommendations to reach . The results will be widely disseminated to the scientific community and relevant stakeholders.

Keywords: quantitative resilience assessment,modelling,green resilience
Causal Reasoning, Policy Opportunities and the Emergence of Self-Serving Narratives. (NARRATIVEss)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

Narratives – the stories people formulate to make sense of the world – contain at their core cause and effect relationships that people use to connect the events they observe. These relationships are crucial for interpreting data, forming expectations, and evaluating policy proposals. This project aims at improving our understanding of the role of economic narratives, their interaction with policy proposals, and how they can be manipulated by economic actors. The ultimate goal of this project is to suggest strategies to follow when faced with contexts in which struggles over policies might generate polarized views of how the world works. The project is divided into three areas and combines ideas and methods at the intersection between economics, sociology, psychology, and computer science. The first area of research involves behavioral experiments in which I will study how narratives react to the cost of policies available to agents. In particular, I will investigate whether agents tend to adopt narratives that are self-serving, that is, compatible with the policies they find least costly. The second area of research focuses on the role that narratives played in shaping political preference in the second half of the XX century. I will consider labor unions to study the factors behind the emergence in the United States of a narrative highlighting their mischiefs. These results could highlight the magnitude and importance of the consequences generated by those that become prevailing narratives in a society. The last area of research will involve a methodological study on how to measure narratives from text. I will work to extend the available methods with the goal of explicitly capturing causal relationships. This contribution could favor the emergence of new work in the field by other researchers who could easily analyze large corpora of text.

Keywords: economic narratives,experiment,behavioral bias,mental models,text as data,labor unions,political economy,machine learning
Microfluidic Platform for Analyzing Sperm Flagellar Beating in a Chemical Gradient (MicroBeaCh)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 279878.4
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

MicroBeaCh aims to exploit the biomimetic approach to unravel harmonized spermatozoa beating that favors natural fertilization. Biochemical stimuli in follicular fluid (FF) are pivotal in guiding sperm cells for their traversal through the cumulus-oocyte complex. FF contains peptides, proteins, steroid hormones, polysaccharides, metabolites, antioxidants, and reactive oxygen species. Despite some preliminary investigations and the potential advantages afforded by microfluidics approaches, a noticeable dearth exists in the unraveling mechanism of spermatozoa beating. MicroBeaCh intends to explore the fundamental beating contributions in sperm cell migration. This will be the first study exploiting computer vision and artificial intelligence approaches to obtain the natural beating behaviors of sperm cells. We believe that the successful accomplishment of MicroBeaCh will establish the foundation of novel parameters for quality sperm selection in application to assisted reproduction, where identifying specific beating patterns will advance the outcomes of the practices.

Keywords: chemotaxis,cumulus,microfluidics,sperm flagellar beating
Supramolecular & Covalent Bonds for Engineering Spatiotemporal Complexity in Hydrogel Biomaterials (SupraValent)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Current biomaterials poorly recapitulate the tough, responsive, and spatiotemporal behavior of native extracellular matrices (ECM). This recapitulation of ECM complexity is imperative to create environments that can effectively communicate with living cells. A key missing component in synthetic ECM-mimetics is spatiotemporal control of material dynamics. Supramolecular biomaterials hold significant promise to fill this need, yet their poor mechanical properties often limit application. I hypothesize that strategic combinations of dynamic supramolecular assemblies with reversible/degradable covalent bonds can lead to tough, hierarchical, and spatiotemporally complex hydrogels. After all, nearly all hierarchical materials in nature are composed of optimized combinations of supramolecular and covalent bonds. In SupraValent, I will test my hypothesis with the design and exploration of spatiotemporal changes to hydrogel properties via covalent modification of 1D supramolecular polymers. SupraValent will first create structure/dynamics/property relationships of supramolecular assemblies between solution-phase studies and hydrogel materials. I will leverage this information to create tough supramolecular biomaterials and bioinks, which allow for the introduction of spatiotemporal gradients and cell-mediated changes (via degradation) to the material’s properties. Then, I will introduce innovative cell/material constructs where the cells create covalent bonds on the materials over the lifetime of culture. Here, genetically modified bacteria will introduce the spatiotemporal complexity into the construct, moving towards living material’s modifications. These studies will transform the way we create and control timescales in dynamic biomaterials, and open supramolecular hydrogels to new applications. Furthermore, this work will provide a much-needed breakthrough to creating life-like materials with controllable properties.

Keywords: tissue engineering,dynamic hydrogels,engineered living materials,bioprinting
Brownian particles in nonequilibrium baths (BRONEB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2493593.75
EU funding (EUR): 2493593.75
Participants: 1
Project status: SIGNED

The power of thermodynamics comes at the expense of certain assumptions and idealizations. An important premise is the concept of a thermal bath which is in contact with the examined system. Typically, such baths are idealized as an infinite reservoir of heat that remains in equilibrium regardless of whether the system in contact is in equilibrium or not. Such description, however, is only valid when the bath relaxation time is much faster than typical time scales of the system. Otherwise, a driven system excites the bath out of equilibrium and will interact with nonequilibrium fluctuations. Recent experiments using colloidal particles within viscoelastic baths, whose relaxation times are comparable to colloidal timescales, have revealed surprising and only poorly understood novel behaviors which are attributed to the nonequilibrium properties of the bath. Examples include particle oscillations inside moving optical traps, a fastened hopping dynamics across potential barriers, an up to 100-fold enhanced rotational diffusion of drifting particles, but also the presence of about one-million-fold increased Magnus forces. Here, we propose a series of novel experiments aiming to uncover the impact of a non-equilibrated bath on the behavior of externally driven colloidal particles but also to exploit such effect for applications. In those experiments we will investigate how nonequilibrium surroundings affect erasure processes of logical information or modify the design of optimal finite time protocols. In addition, we will construct an unprecedented microscopic engine which – unlike conventional heat engines – is not operated between two heat baths but which is periodically coupled to nonequilibrium baths with different relaxation times. The selection of the examples being pursued within this proposal has been chosen not only to demonstrate the manifold consequences of nonequilibrium baths but also provide possible overlaps beyond the field of soft condensed matter.

Keywords: colloidal particles,nonequilibrium systems,nonequilibrium baths,non markovian
FIRST-IN-CLASS MYC INHIBITOR: THE MAKING OF A BREAKTHROUGH CANCER THERAPY (MYCureX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-07-01
End date: 2025-12-31
Duration (months): 30.0
Total project cost (EUR): 3563578.25
EU funding (EUR): 2494504.0
Participants: 1
Project status: SIGNED

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with very few and often ineffective therapeutic options. Despite recent advances, cancer therapies remain ineffective and/or highly toxic. Our approach is targeting MYC, a function essential to cancer cells that allows them to survive and develop resistance to therapy. In contrast to standard drugs, inhibiting MYC selectively blocks tumor progression without causing important side effects. MYC has been considered undruggable for a long time, and no clinical MYC inhibitor is yet marketed. Peptomyc’s first-in-class drug, OMO-103, is a cell-penetrating mini-protein that derives from Omomyc, the best MYC inhibitor known to date. OMO-103 recently completed a Phase 1 clinical trial that confirmed its safety and clinical activity in all-comers solid tumor patients, causing a 49% tumor shrinkage in a PDAC patient and stabilizing the disease of 8 out of 12 evaluable patients. Moreover, using AI we identified a predictive and a pharmacodynamic circulating biomarker signatures, and generated companion diagnostic for stratification and real-time response monitoring tests for OMO-103. OMO-103 and its companion diagnostic tests offer a promising therapeutic option for a disease in great need and could apply to treat many other cancer indications. The next steps and goals of this MYCureX project consist of conducting a Phase 1b trial in 1st-line PDAC patients, combining OMO-103 with the standard of care, to evaluate its safety and clinical activity; refining the companion diagnostic prototypes and app; securing the scale-up of the innovation by developing a commercial-scale compatible manufacturing process; and expand the applications of OMO-103 and Peptomyc's drug pipeline. By completing MYCureX, Peptomyc will consolidate the therapeutic potential of MYC inhibition in cancer patients, improving their survival and quality of life while establishing itself as a European leader biotech in MYC targeting.

Keywords: myc,undruggable target,cell penetrating mini protein drug,first in class,first in modality,companion diagnostic,machine learning enabled biomarkers discovery,omics