Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Game Changer of Physiotherapy towards Arthrosis Prevention (PANDA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SmartR is a French e-health company that uses cutting-edge technologies to provide advanced solutions for the management of functional rehabilitation over the world. PANDA project started in October of 2016 with the aim to allow rehab patients to access to personalized support, close to that of professional sportsmen without constraint, for a fraction of the current price of rehab. PANDA will benefit the entire healthcare system, loweing costs for public and private insurances by 70%. Our core business is to ensure a quality recovery of patients during knee rehab in optimal conditions, for both patients and professionals (e.g. physiotherapists). Our product comes to devise an intelligent system that assist patients in rehab, providing them increased autonomy, and to accelerate recovery from knee disorders by 30%. The project has started in touch with physiotherapists and sport doctors, transmitting us their demands for more effective rehab treatment, and what patients need to better and faster recovery from functional disorders. We believe joint with collaborating doctors' support the optimized version of our system will potentially will upgraded towards Arthrosis prevention. For the present scope, e aim to reach the physiotherapy and knee rehab market which, in Europe, it is estimated that 40M patients undergoing knee rehab programs each year (400,000 patients in France, with 80,000 physiotherapists). As patients represent a greater share of the market than healthcare professionals, we will aim to reach patients through various channels, establishing commercial agreements with health insurance companies and pharmacies to offer our product; also, through physiotherapists and specialized rehab clinics – also considered end-users of PANDA – to recommend our product. Accordingly, we are expecting, in a 5-year period of PANDA commercialization in Europe and overseas, to generate €17.1M revenues and €12.2 profit, and ROI of 3.1.

Keywords: functional pathologies,joints,accelerated rehab,personalized programs,physiotherapy,healthcare system,remote monitoring,autonomy,measurements accuracy
Ekoservis Membrane Modular Filtration system (EKO_MEMOF)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Slovakia
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

EKOservis Membrane Modular Filtration System The intention of the innovation project itself is to solve the technological system of wastewater treatment using flat sheet membranes to achieve a high degree of cleaning. The project focuses on municipal and industrial sewage treatment plants meeting the requirements of Directive 76/160/EEC concerning the quality of bathing water. The project contributes to the protection of water and water resources, to the re-use of waste water, and to the improvement of water quality in watercourses and reservoirs. The project provides advanced solutions for water purification and its further use in a sustainable manner. The aim of the innovation project is to introduce a process of membrane filtration into practice. We want to show that the opportunities for use of membrane filtration are wide - ranging from a single family house to the water treatment plants with a capacity of more than 50,000 m3 of purified waste water per day, which are intended for cities with more than 100,000 inhabitants.

Keywords: watter treatment
Direct Pathway Cloning of Neglected Bacteria in the Hunt for Novel (Bio-)Chemistry (DiPaC_MC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

To overcome recent global health threats, such as antibiotic resistance, a resurgence in the discovery of new chemical and thus biomedical diversity from microbial sources is needed. Genome mining in combination with heterologous expression is an approach that will overcome these challenges. It involves incorporation of yet uncharacterized natural product genetic loci into a fast growing heterologous host. For this approach, a prolific source of novel natural product gene clusters is vital. Our collaboration with the Zentralinstitut für Ernährungs- und Lebensmittelforschung (ZIEL, Technische Universität München) provides direct access to bacterial isolates completely unexplored in regards to their potential for natural product biosynthesis. Our genome analyses have revealed that many of the ZIEL isolates harbor a large number of uncharacterized natural product gene clusters. Thus, the aim of this proposal is to heterologously express natural product gene clusters from these neglected bacteria to discover novel natural product (bio-)chemistry. Because these organisms are poorly studied, the likelihood of discovering rare or novel biochemistry is immensely increased. Here, we will utilise a novel combination of synthetic biology techniques referred to as Direct Pathway Cloning. This will enable expression vectors to be constructed by large-amplicon PCR (up to 20kb) coupled to Gibson assembly. Development of the methodology is set to revolutionise synthetic biology and metabolic engineering. Downstream outcomes of this proposal will be the identification of novel, potentially bioactive natural products, the characterisation of unusual biochemistry and the addition of enzymes to the ‘biocatalytic toolkit’ for natural product synthesis and structural alteration.

Keywords: natural products,biosynthesis,genome mining,synthetic biology,biosynthetic engineering,antibiotic resistance,heterologous expression,biosynthetic gene cluster,non ribosomal peptide,polyketide
Decarb City Pipes 2050 - Transition roadmaps to energy efficient, zero-carbon urban heating and cooling (DecarbCityPipes 2050)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Austria,Spain,Spain,Ireland,Sweden,Switzerland,Slovakia,France,Netherlands,Netherlands
Call: Supporting public authorities to implement the Energy Union (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-07-01
End date: 2023-12-31
Duration (months): 42.0
Total project cost (EUR): 1894032.5
EU funding (EUR): 1894032.5
Participants: 13
Project status: SIGNED

Climate urgency calls on all political levels to act more stringent and faster. This proposal is the first to unite cities across Europe to work out actionable, spatially differentiated transition roadmaps to decarbonise heating and cooling for buildings in 2050, taking up the challenge to phase out natural gas in heating. Transitioning the sector to energy-efficient, renewable and zero-carbon solutions is key to meet the EU climate and energy targets. Given the long life-cycles of the grid infrastructures involved, there is an urgency to start the planning of this transition today. But how? What first? Which systems? How to govern this process? Increasing complexity of the energy system together with technological uncertainties require a high level of knowledge and skills to act wisely. Cities are ill-equipped for this. They lack capacity and skills as well as legal empowerment to act. Decarb City Pipes 2050 showcases how local authorities can succeed in this challenge. Bilbao, Bratislava, Dublin, Munich, Rotterdam, Vienna and Winterthur, seven cities from frontrunners to beginners join forces to learn from each other and elaborate innovative responses together. They explore pathways suitable for their local challenges and build up skills in the use of data, planning tools and instruments, techno-economic as well as process and transition management knowhow. In a participatory process with stakeholders, they develop tangible transition roadmaps, building up trust and commitment for its implementation along the way. In deep peer-to-peer exchanges, cities and utilities share knowledge to benefit from other perspectives, stages of advancement and planning traditions. Together, they will advocate for the needed changes to framework conditions. Enriched by a distinguished advisory board, the project aims to empower >220 public officers and improve >50 policies. Ultimately, it strives to motivate and support >80 more cities to start the same roadmap process.

Keywords: heating,cooling,transition roadmap,renewables,district heating,zero carbon,climate action,green gas,governance framework,energy planning,peer to peer learning,cities,local authorities
Optimal treatment for patients with solid tumours in Europe through Artificial intelligence (OPTIMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Germany,Estonia,Italy,Germany,Germany,Spain,Germany,Spain,Germany,Switzerland,Belgium,Sweden,Sweden,Switzerland,Belgium,Sweden,France,France,France,Netherlands,Netherlands,Netherlands,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Luxembourg,Portugal
Call: Optimal treatment for patients with solid tumours in Europe through Artificial Intelligence (H2020-JTI-IMI2-2020-23-two-stage, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 22689967.0
EU funding (EUR): 10459997.0
Participants: 39
Project status: SIGNED

OPTIMA is a multi-stakeholder-led consortium with the vision that each and every patient should have access to the most up-to-date individualised treatments and to innovative therapies. In that perspective, we will design, develop and deliver the first interoperable and GDPR compliant European real-world oncology data and evidence generation platform, along with decision support toolsets for prostate, lung and breast cancer. By designing this platform from the onset based on the needs of the clinicians and patients in an inclusive and sustainable way, OPTIMA aims to strengthen shared decision-making based on innovative data and AI-driven technology and tools. To achieve our vision, we have united the key partners from other data-driven European wide oncology initiatives (PIONEER, EHDEN, HARMONY) in our project along with Europes leading clinicians in the fields of breast, prostate and lung cancer that all have leading roles in medical societies such as ERS, ESMO, and EAU. At the core of the OPTIMA project are the major guideline offices of the three indications, whilst the project is further strengthened by patient advocacy groups, well-known academic partners and 6 SMEs as partners covering the needed expertise to implement OPTIMA successfully. The platform will build on existing open source solutions such as the OMOP-CDM, tranSMART and OHDSI ATLAS whilst developing novel AI models based on federated learning to facilitate knowledge discovery. At the start of the project, we will already have access to datasets covering over 200M people in Europe, along with data from high quality patient cohorts for AI model building. Moreover, the platform will be hosted in-kind on existing infrastructure provided by Helmholtz Institute in Germany. Finally, OPTIMA envisions sustainability of its platform through a value-based approach with various business models for commercial users.

Keywords: big data analysis,real world evidence,guidelines,artificial intelligence
Demand driven co-creation for public entities. (inDemand)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Innovation actions
Countries involved: Spain,Belgium,Finland,France
Call: Piloting demand-driven collaborative innovation models in Europe (H2020-SC6-CO-CREATION-2016-3, 2016)
Start date: 2017-09-01
End date: 2020-11-30
Duration (months): 39.0
Total project cost (EUR): 2499940.0
EU funding (EUR): 2499940.0
Participants: 12
Project status: CLOSED

European public entities are responsible of the provision of critical services like healthcare, education, justice, etc. In order to improve the delivery of their services to citizens over time they need to incorporate innovation. This innovation is often developed and produced by the private sector, for example in the form of technology. A standard model of incorporating innovation is through technology-push: private suppliers develop their innovative solutions, with limited contact and exchange with the public entities, and then try to commercialize them. This limited contact often leads to solutions that are not completely tailored or addressing a profitable need, as there is no real engagement in collaborative relations with the public administration. This sub-optimal interaction and knowledge of the customer needs and culture, leave start-ups and Small and Medium Enterprises (SMEs) with un-marketable products, discouraging them to fully engage with an important market (Public Procurement in Europe is estimated at €2 trillion, close to 20% of EU GDP ).

Keywords: business support,co creation
Deciphering the Role of Huntingtin in Energy Supply for Axonal Transport in Health and Huntington’s Disease (FUELING-TRANSPORT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 2369941.0
EU funding (EUR): 2369941.0
Participants: 2
Project status: SIGNED

Fast axonal transport (FAT) of brain-derived neurotrophic factor (BDNF) is essential for brain function. It depends on huntingtin (HTT), the protein that when mutated causes Huntington’s disease (HD), a devastating and still incurable disorder. Unmet scientific needs: BDNF is regulated by neuronal activity and its transport requires energy. Yet we do not know if FAT of BDNF is regulated by neuronal activity and if HTT facilitates activity-dependent transport. The energy sources for FAT of BDNF and their regulation by activity remain unclear, as do the exact mechanisms of BDNF transport reduction in the HD-causing mutation. Novel hypothesis: HTT plays a key role in channeling energy by coupling energy production by glycolytic enzymes on vesicles to consumption by molecular motors for efficient axonal transport. This function is altered in HD and plays a crucial role in disease progression. By providing energy directly to vesicles, we can restore transport and slow down neurodegeneration in HD. Aim 1: investigate energy sources for axonal transport and their regulation by HTT upon high neuronal activity. Aim 2: investigate how pathogenic mutation in HTT affects response to neuronal activity and vesicles capacity to produce energy. Aim 3: restore energy sources in HD to rescue axonal transport and slow down neurodegeneration. Impact. This work will advance the understanding on how electrical activity essential for brain function regulates energy metabolism to fuel transport, specifically transport of BDNF. We will reveal essential new knowledge on the HTT function and dysfunction. This will likely lead to novel therapeutic strategies for HD. Feasibility: we have expertise in developing innovative microfluidic circuits for studying axonal transport in reconstituted neuronal circuits and in identifying new metabolic and signaling pathways. This, together with my expertise on HTT biology, puts my lab in a unique position to fulfill this ambitious programme.

Keywords: huntington s disease,huntingtin,axonal transport,vesicles,bdnf,glycolysis,microfluidic approaches
SHOWCASing synergies between agriculture, biodiversity and Ecosystem services to help farmers capitalising on native biodiversity (SHOWCASE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Estonia,Italy,Italy,Germany,Spain,Italy,Belgium,Switzerland,Romania,Sweden,Hungary,Bulgaria,France,Netherlands,Netherlands,United Kingdom,Portugal,United Kingdom
Call: Biodiversity in action: across farmland and the value chain (H2020-SFS-2019-2, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 7999837.5
EU funding (EUR): 7999771.25
Participants: 25
Project status: SIGNED

The slow adoption by the agricultural sector of practices to promote biodiversity are thought to originate from three interrelated issues. First, we know little about which incentives effectively motivate farmers to integrate biodiversity into daily farm management. Second, few studies so far have produced evidence that biodiversity-based approaches produce benefits in terms of key variables for farmers (yield, profit). Third, there is a large communication gap between the scientists investigating biodiversity-based farming practices and the farmers that have to implement them. To overcome these barriers, SHOWCASE will review and test the effectiveness of a range of economic and societal incentives to implement biodiversity management in farming operations and examine farmer and public acceptance. Focus will be on three promising approaches: (i) result-based incentives, (ii) involvement in citizen science biodiversity monitoring and (iii) biodiversity-based business models. SHOWCASE will co-produce together with stakeholders a solid interdisciplinary evidence for the agro-ecological and socio-economic benefits of biodiversity management in 10 contrasting farming systems across Europe. SHOWCASE will also design communication strategies that are tailor-made to farmers and other key stakeholders operating in different socio-economic and environmental conditions. SHOWCASE will develop a multi-actor network of 10 Experimental Biodiversity Areas in contrasting European farming systems that will be used for in-situ research on biodiversity incentives and evidence for benefits as well as knowledge exchange. This network will be used to identify and test biodiversity indicators and targets relevant to all stakeholders and use them in a learning-by-doing approach to improve benefits of biodiversity management on farms both within the network and beyond.

Keywords: economic incentives,ecosystem service benefits,public goods,knowledge exchange,citizen science
Gendering and Decolonising Climate Change Research: Exploring the Waterberg, South Africa (GenDecCCR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2023-11-14
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

For decades the living biosphere has been over-exploited and subjected to a corporate-industrial food system and fossil-fuel extractivism, both practices destroying ecosystems and releasing pathogens. Global South populations – most notably women – are particularly impacted by these inter-connected ecological, social, and economic crises of our time. At the same time, however, women are a pivotal force in mobilising struggles for environmental and climate justice. This project specifically offers the first in-depth exploration of climate justice activism led by women living adjacent to coal mines and coal power stations in a ‘new frontier space’ of coal extraction in South Africa, as emblematic of the crises of our time and transformative responses to such. The project’s overall aim is to contribute towards current climate change and climate justice research and activism, through adopting a unique gendering and decolonising theoretical framework and methodology. It aims to not only develop and conduct a unique approach to conducting interdisciplinary social science research but also to have a concrete impact on the capacity of ordinary women to resist the dire effects of mega-coal mining projects on their lands and communities. The (i) methodological, (ii) theoretical and (iii) concrete objectives of the proposed research are: develop innovative feminist, participatory action research methodologies in response to the climate crisis; produce an original and interdisciplinary history and presence of the Waterberg, drawing on political ecological, feminist and decolonial theoretical frameworks in order to contribute towards understanding the historical and colonial causes of climate change in the Waterberg; support the collective self-organisation of women in the Waterberg who are campaigning against extractivism and climate change; and target future North-South research and civil society collaborations by connecting organisations.

Keywords: decolonial perspectives,climate change