Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bridging East and West: Wisdom Literature in Mesopotamian and Greek Traditions (BRISDOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

The project Bridging East and West: Wisdom Literature in Cuneiform and Greek Traditions (BRISDOM) explores similarities and differences in wisdom and its usages in Mesopotamian and Greek traditions. BRISDOM represents the first ever attempt to provide a comprehensive study of wisdom in Mesopotamia and Greece. Wisdom reflects on some of the most fundamental questions of mankind, such as the meaning of life, mortality, and relations with the divine. Wisdom literature had an enormous circulation in both Mesopotamia and Greece and includes very different text types such as sayings, proverbs, fables, books of instructions, diatribes and dialogues. The project has three main objectives: (A) the definition of the corpus of wisdom literature in Mesopotamian and Greek traditions; (B) the definition of the conceptualization of wisdom in Mesopotamian and Greek traditions; (C) the comprehension of similarities and differences of wisdom literary motifs in Mesopotamian and Greek traditions. In order to achieve these objectives BRISDOM will developed a different methodology from previous studies on literary and cultural relations between the East and the West. Rather than focusing on historical connections, BRISDOM will compare the socio-cultural context of wisdom in Mesopotamia and Greece.

Keywords: assyriology,sumerian and akkadian literature,classics,wisdom
Genetic, behavioural and cognitive mechanisms underpinning the association between mother and offspring mental health problems: mental (M) health (H) intergenerational transmission (INT) -(MHINT) (MHINT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-12-01
End date: 2023-11-30
Duration (months): 72.0
Total project cost (EUR): 1499611.0
EU funding (EUR): 155331.82
Participants: 2
Project status: SIGNED

Despite decades of research, and the introduction of parenting interventions, children of mentally ill mothers remain substantially more likely to have mental health problems themselves. I propose to shed new light on why mental health problems in a mother are passed on to her child, and help break this reinforcing cycle of mental health risk across generations. In order to harness the potential of modifying parenting for the prevention of child mental health risk, I will study parenting using more detailed, ecologically valid and genetically sensitive designs than have been done before. Objectives: 1: To investigate the respective role of genetic and environmental (chiefly parenting) mechanisms in explaining associations between mother and child mental health. HOW: using a consortium of international cohorts with intergenerational genetic and phenotypic data (n>10,000) and, for the first time, modeling genetic risk which is and is not transmitted from mother to child to test alternative hypotheses. 2: To identify behavioural manifestation of maternal mental health, in observed mother-infant interaction, in an ecologically valid way. HOW: recording 300 mother- child dyads at home, using novel wearable cameras, in the next generation of a key cohort (ALSPAC-G2). 3: To identify cognitive underpinnings of maternal behaviour. HOW: including cognitive tasks (with eye tracking) as new measures in ALSPAC-G2, applying computational models to cognitive and (uniquely) real life data (measured in 2). 4: To establish whether modification of maternal parenting (highlighted in 1-3), changes child mental health. HOW: systematic review of parenting intervention trials and new synthesis methods to extract which intervention components reduce child mental health problems. My study will provide critical new evidence regarding the nature of parenting interventions that have potential to improve child mental health and break intergenerational transmission of mental health problems.

Keywords: intergenerational,maternal mental health,parenting
ACOUSTIC MARKERS FOR ENHANCED REMOTE SENSING OF RADIATION DOSES (AMPHORA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Belgium,Belgium,Netherlands
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2017-11-01
End date: 2022-04-30
Duration (months): 54.0
Total project cost (EUR): 3932775.0
EU funding (EUR): 3932775.0
Participants: 6
Project status: CLOSED

Approximately 50% of all cancer patients receive radiation therapy as part of their treatment. The aim is hereby to maximise tumor irradiation and to minimize healthy tissue irradiation. This implies a need for appropriate dosimetry strategies that can effectively measure the actual radiation dose imparted on the tumor. However, state-of-the-art dosimetry cannot quantify the dose distribution in (and around) the tumor, hereby inhibiting the full potential of radiotherapy. AMFORA aims to develop a non-invasive in-situ dosimetry system for radiation therapy with the potential of on-line dose assessment by casting ultrasound contrast agents (UCAs) into dose sensing theranostic devices. UCAs will be upgraded to injectable dose-sensitive and targeted devices that gather in tumor tissue and translate imparted radiation dosage into a modulation of their acoustic response upon ultrasound interrogation. Tailored ultrasound imaging and advanced signal processing algorithms will be developed to extract the (change in) acoustic signature of UCAs from backscatter data and to translate this information into a 2D or 3D dose distribution map. The specific objectives of this project are the design, development and pre-clinical validation of the aforementioned UCA based dosimetry system and a customised ultrasound read-out technology. Upon successful completion, AMFORA will have enabled the assessment of the effective radiation dose distribution in (and around) the tumor, offering an advanced and objective means to compare and evaluate treatment efficacy of different radiotherapy modalities. Such novel technology would revolutionize quality assurance and treatment follow up in radiotherapy, which also unmistakably will lead to increased patient safety and improved treatment protocols. Moreover, AMFORA is expected to trigger an avalanche of novel technologies for radiation therapy delivery and to pave the way for other in-vivo UCA based distributed sensing applications.

Keywords: microbubbles,sonography,molecular acoustics
DNA Damage Response-instructed Macrophage Differentiation in Granulomatous Diseases (DDRMac)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Macrophage differentiation programs are critical for the outcome of immunity against infection, chronic inflammatory diseases and cancer. How diverse inflammatory signals are translated to macrophage programs in the large range of human pathologies is largely unexplored. In the last years we focused on macrophage differentiation in granulomatous diseases. These affect millions worldwide, including young adults and children and tend to run a chronic course, with a high socioeconomic burden. Their common hallmark is the formation of granulomas, macrophage-driven structures of organized inflammation that replace healthy tissue. We revealed that macrophage precursors in granulomas experience a replication block and trigger the DNA Damage Response (DDR), a fundamental cellular process activated in response to genotoxic stress. This leads to the formation of multinucleated macrophages with tissue-remodelling signatures (Herrtwich, Cell 2016). Our work unravelled an intriguing link between genotoxic stress and granuloma-specific macrophage programs. The molecular pathways regulating DDR-driven macrophage differentiation and their role in chronic inflammatory pathologies remain however a black box. We hypothesize that the DDR promotes macrophage reprogramming to inflammation-maintaining modules. Such programs operate in granulomatous diseases and in chronic arthritis. Using state-of-the art genetic models, human tissues and an array of techniques crossing the fields of immunology, cell biology and cancer biology, our goal is to unravel the macrophage-specific response to genotoxic stress as an essential regulator of chronic inflammation-induced pathologies. The anticipated results will provide the scientific community with new knowledge on the role of genotoxic stress in immune dysregulation and will carry tremendous implications for the therapeutic targeting of macrophages in the context of chronic inflammatory diseases and cancer.

Keywords: macrophages,granulomatous diseases,dna damage response,genotoxic stress
Securing Medical Data in Smart Patient-Centric Healthcare Systems (SERUMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Israel,Austria,Spain,Cyprus,Belgium,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Toolkit for assessing and reducing cyber risks in hospitals and care centres to protect privacy/data/infrastructures (H2020-SC1-FA-DTS-2018-1, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 4370062.5
EU funding (EUR): 4370059.0
Participants: 12
Project status: SIGNED

In order to achieve high quality healthcare provision, it is increasingly important to collect highly confidential and personal medical data that has been obtained from a variety of sources, including personal medical medical devices and to share this through a variety of means, including public networks and other systems whose security cannot be implicitly trusted. Patients rightly expect full privacy, except where permission has been explicitly given, but they equally expect to be provided with the best possible medical treatment. Evidence suggests that integrating home-based healthcare into a holistic treatment plan is more cost effective, reduces travel-associated risks and costs, and increases the quality of health-care provision, by allowing the incorporation of more frequent home-, work- and environment-based monitoring and testing into medical diagnostics. There is a strong and urgent demand to deliver better, more efficient and more effective healthcare solutions that can achieve excellent patient-centric healthcare provision, while also complying with increasingly strict regulations on the use and sharing of patient data. This provision needs to be multi-site, crossing traditional physical and professional boundaries of hospitals, health centers, home and workplace, and even national borders. It needs to engage hospitals, medical practitioners, consultants and other specialists, as well as incorporating patient-provided data that is produced by personal monitoring devices, health-care apps, environmental monitoring etc. This creates huge pressures The goal of the SERUMS project is to put patients at the center of future health-care provision, enhancing their personal care, and maximizing the quality of treatment that they can receive, while ensuring trust in the security and privacy of their confidential medical data.

Keywords: patient centric healthcare,trust,patient safety,blockchain,gdpr,data fabrication
Gravitational Universe: Challenges and Opportunities (GRU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Italy,Italy,France,United States,Portugal,Japan,Canada
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 280600.0
EU funding (EUR): 280600.0
Participants: 9
Project status: SIGNED

Gravitational Universe: Challenges and Opportunities The landmark detection of gravitational waves (GWs) emitted by merging black-hole and neutron-star binaries has opened a new era in physics, giving us access to the strong-field regime of the gravitational interaction. The wealth of data coming from current and future GW detectors (such as 3G, LISA, PTA) will provide an opportunity to challenge current paradigms, exploring fundamental physics from an entirely new perspective, and eventually finding new physics. In this new observational window, we could learn that general relativity is not adequate to describe the strong-field regime of gravity; new fundamental fields beyond the standard model, or new kinds of compact objects, could challenge current understanding of dark matter and dark energy. In order to reach these results, the impressive experimental effort put in place will not be sufficient if not accompanied by a similar effort by the theoretical and the data-analysis communities. Severe theoretical and conceptual problems need to be overcame before the new generation of detectors is operating. On one hand, we need to develop new data-analysis algorithms, to extract meaningful results from the impressive amount of data which will be delivered. On the other hand, we need to develop theoretical models of GW sources which do not assume the standard theories and paradigms which we want to test, in order to perform non-biased tests and to use observational results to address fundamental problems. It is of utmost importance that scientists with different expertise and addressing different challenges exchange their views and learn from each other’s problems. The proposed studies can be loosely classified into four groups with considerable overlap: i) Perturbation techniques in general relativity and beyond ii) Non-linear simulations of binary compact objects beyond general relativity iii) GWs from the dark universe iv) Data analysis for GW experiments

Keywords: black holes,tests of gravity,post newtonian approximation,numerical relativity,data analysis for gravitational wave experiments
Private Machine Learning (PRIMAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2024-02-28
Duration (months): 24.0
Total project cost (EUR): 185464.32
EU funding (EUR): 185464.32
Participants: 1
Project status: SIGNED

Machine learning algorithms are data-hungry, and perform better when exposed to more and more data. Such data is being collected in massive amounts by internet giants, and is often sensitive and private. Examples include the purchases and browsing history of users, their health data and exercise activity, locations they travel to and messages they type into their mobile phone. The amount of data being collected can be significantly reduced using cryptographic techniques, in particular, using secure multiparty computation. Secure computation enables mutually distrustful parties to compute a joint function of their inputs without revealing the inputs to one another. In this research, we will address secure computation techniques of machine learning tasks. The first task is private classification: One party holds a model trained on a sensitive dataset, and another party holds a sample and wishes to evaluate the model on that private sample. Our objective is to fulfill this task while achieving significantly stronger security notion than previous works, that is, security even if one of the parties deviates from the protocol specifications (malicious security). The second task is federated learning, a techniques that enables thousands of participants to train a neural network on their joint data but without revealing the data to one another. However, a recent work showed that such task is susceptible to injection of backdoors, and a user can manipulate the joint model to his/her own benefit, significantly reducing the usefulness of federated learning in practice. Our objective is to guarantee immunity to such injections. The two objectives will be achieved by improving specific cryptographic building blocks, and applying them for these applications. PRIMAL will speed up secure computation in practice, and carries immense potential to enhance privacy in the digital era.

Keywords: privacy preserving machine learning,cryptography,machine learning
Smartphone A new concept in hearing…”: an interactive real-time embedded audio solution that offers a significant/disruptive change in hearing technology and market. (Smartphone-ANCIH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Effective hearing ability influences individuals’ overall quality of life, particularly in situations (such as in work-places, meetings, classrooms, social gatherings, or using audio devices) where unwanted noise constantly tests and challenges our audio processing capabilities. In these situations all existing hearing aids share a common underlying concept flaw due to the fixed position of the microphone and the lack of user interactivity. Coupled with inelegant and unfashionable designs, this causes many hearing-impaired individuals to opt out of using hearing aids and withdraw from these social/work group situations. The Smartphone platform is an excellent example of technology with the potential to enhance the audio experience of individuals with hearing loss whilst blurring the distinction between hearing and consumer technologies. Combined with our innovative audio separation techniques and pioneering wireless technology, it removes the social stigma and provides a significant step change in hearing market accessibility, dispensing and affordability allowing everyone to live fuller normal lives. Auriplex’s Smartphone “A new concept in hearing…” is innovative not only in technology but also in the market reach strategy: the solution would be aimed at a new market that is distinctly different from current hearing aid offerings but at the same time will be familiar as a consumer product and a logical next step with most technology users not only in the hard-of-hearing but also in the hearing world. A disruptive innovation everyone will hear about!

Keywords: blind source separation bss high performance audio music hearing sound separation miniature wireless earpiece smartphone interactive sdk healthcare entertainment communication real time
Subsurface Evaluation of Carbon capture and storage and Unconventional Risk (SECURe)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Poland,Norway,Poland,Poland,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom
Call: Measuring, monitoring and controlling the potential risks of subsurface operations related to CCS and unconventional hydrocarbons (H2020-LCE-2017-RES-CCS-RIA, 2017)
Start date: 2018-06-01
End date: 2021-05-31
Duration (months): 36.0
Total project cost (EUR): 8932483.49
EU funding (EUR): 8450608.49
Participants: 18
Project status: CLOSED

Subsurface Evaluation of CCS and Unconventional Risks (SECURe) will gather unbiased, impartial scientific evidence for risk mitigation and monitoring for environmental protection to underpin subsurface geoenergy development. The main outputs of SECURe will comprise recommendations for best practice for unconventional hydrocarbon production and geological CO2 storage. The project will develop monitoring and mitigation strategies for the full geoenergy project lifecycle; by assessing plausible hazards and monitoring associated environmental risks. This will be achieved through a program of experimental research and advanced technology development that will be demonstrated at commercial and research facilities to formulate best practice. We will meet stakeholder needs; from the design of monitoring and mitigation strategies relevant to operators and regulators, to developing communication strategies to provide a greater level of understanding of the potential impacts. The SECURe partnership comprises major research and commercial organisations from countries that host shale gas and CCS industries at different stages of operation (from permitted to closed). We will form a durable international partnership with non-European groups; providing international access to study sites, creating links between projects and increasing our collective capability through exchange of scientific staff. SECURe will provide a legacy of: 1. A network of experimental and industrial field sites as a proving ground for cutting edge technologies and to enable knowledge transfer between sectors; 2. A platform for international cooperation; 3. A scientifically sound, unbiased and independent best practice for baselining, monitoring, mitigation and remediation – within a risk-assessment framework; 4. Models and best practice guidelines for engaging different stakeholders including citizens through participatory monitoring; 5. A formal continuous training programme for researchers and students.

Keywords: co2 storage,unconventional hydrocarbons,environmental baseline,monitoring,remediation,mitigation