Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Early-Stage Organocatalysis (ESO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Organocatalysis has drastically advanced stereoselective chemical synthesis. From an underdeveloped niche area, it has become the most frequently applied approach to asymmetric synthesis. Organocatalysis is also developing into a technology, which can be used to make pharmaceuticals, scents, and other fine chemicals. However, the early stages of industrial chemistry, the upgrading of hydrocarbon-based alkenes, arenes, and alkanes, are still largely dominated by heterogeneous and transition metal catalysts. Here we will address the question if a selective, Early-Stage Organocatalysis (ESO) can be developed that directly delivers high-value substances from abundantly available hydrocarbon feedstock chemicals, while significantly saving energy and other resources. During the last few years, we have developed confined organic acids as a new catalyst class that features enzyme and zeolite-inspired active sites with well-defined pockets for selective substrate recognition and catalysis. These catalysts offer a widely tunable reactivity range, reaching extreme levels with turnover numbers exceeding 106 in challenging asymmetric carbon-carbon bond forming reactions, and approaching “magic acid” reactivity toward the activation of olefins. We now aim to take confined acid catalysis to another level by designing new, even more reactive acids that enable the utilization and valorization of steam-cracker-based hydrocarbons in selective organocatalysis. Specifically, we propose three aims: (1) Developing asymmetric olefin hydrofunctionalizations including hydrations and hydroarylations; (2) An early stage functionalization of simple arenes such as benzene and toluene via highly stereoselective and regioselective electrophilic aromatic substitution reactions; and, as the ultimate test of extreme reactivity, (3) we propose organocatalytic, asymmetric reactions of alkanes. The all-underlying goal will be the design and development of organocatalysts of the next generation.

Keywords: organocatalysis,selective catalysis,hydrocarbon chemistry
Non-invasive follow-up of urinary tract cancers (ENSURE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal,Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 165000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Bladder cancer is the most common malignancy of the urinary tract with 573,000 new cases and 213,000 deaths in 2020 worldwide and affecting more men than women in a 4:1 ratio. Bladder cancer has the highest lifetime treatment costs per patient of all cancers, which is mainly attributed to the intensive follow-up procedures of patients after diagnostics and surgery. Follow-up is made recurring to extremely invasive and low-patient compliant tests. ENSURE aims to validate the technological and business feasibility of the electronic nose technology developed in the ERC Starting Grant SCENT by establishing the proof-of-concept for the non-invasive follow-up of bladder cancer patients. To accomplish this, we will approach the project from both Technical and Business perspectives, with a perfect synergy between the research and business teams, and a close contact with clinical collaborators and stakeholders.
High-Field Magic-Angle Spinning Electron Paramagnetic Resonance (MASEPR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 1
Project status: SIGNED

Dynamic Nuclear Polarization (DNP) is the most widely applicable method for solving the main problem of nuclear magnetic resonance (NMR): its low sensitivity. This is achieved by polarization transfer from electron spins to nuclear ones, allowing for up to two orders of magnitude signal enhancement, which enabled the expansion of NMR to multiple systems previously unamenable to it. Despite two decades of extensive research, DNP is yet to reach its full potential, the bottleneck being the quantum-mechanical understanding. While Electron Paramagnetic Resonance (EPR) experiments have provided multiple insights on static DNP mechanisms, leading to improved DNP experiments, analogous EPR experiments for Magic Angle Spinning (MAS)-DNP, the most prolific DNP variant, were never performed. Instead, our understanding of MAS-DNP relies on theoretical considerations and numerical simulations, which naturally cannot capture the entire picture. The main obstacle for MAS-EPR is the complexity of the instrumentation and lack of methodology to perform EPR experiments under characteristic MAS-DNP conditions: high magnetic fields, cryogenic temperatures, and MAS. This project aims to bridge this crucial gap. We have recently recorded the first high-field MAS-EPR spectra, using a unique high-field dual DNP/EPR spectrometer specifically tailored to the investigation of DNP mechanisms, designed and constructed in my lab. In this project, we will expand the experimental capabilities by developing the dedicated hardware and establishing the methodology for high-field, cryogenic MAS-EPR. This will allow, for the first time, to experimentally observe the electron spin dynamics in MAS-DNP, thus deciphering the DNP mechanisms. This will unlock the full potential of MAS-DNP, allowing for systems currently unamenable to NMR to benefit from the atomic-level structural and dynamical information NMR provides, having profound effects in chemistry, structural biology and material science.

Keywords: electron paramagnetic resonance epr,high field epr instrumentation,dynamic nuclear polarization dnp,dnp instrumentation,epr method development,dnp method development
Enabling the integration of multi-functional reliable metamaterials in real-life industrial applications for enhancing structural and vibrational behavior (METRAMAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Belgium,Norway,Italy,United States
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2690215.2
EU funding (EUR): 2690215.2
Participants: 10
Project status: SIGNED

The manufacturing industry is fundamental to the technological sovereignty and competitiveness of the European economy. To maintain the leading position, the sector requires continuous innovations, exploring the limits of material properties. This is particularly the case in high-end technology applications, such as lithography machines and micro-electromechanical systems (MEMS) industry, where the limits of conventional materials come into sight. Metamaterials, built up from rationally, pre-designed architected substructures, hold the promise to outperform conventional materials and redefine the boundaries of industrial design practices. The metamaterial potential can drive the much-needed transformational changes in European manufacturing industry. However, the wide-spread use of metamaterials is hindered by the lack of knowledge of (i) design-for-production principles for metamaterials, (ii) integration at component and system level and (iii) design-for-reliability of metamaterials. METRAMAT will train and deliver 10 researchers skilled in metamaterial development by researching and creating a combined set of design, simulation, manufacturing, testing, reliability assessment and integration tools. The involvement of MEMS, lithography and additive manufacturing industries ensures that scientific training is tuned to existing industrial challenges requiring new fundamental solutions, such as positioning accuracy, sensor sensitivity or shielding of external vibrational disturbances, with emphasis on design for manufacturability and reliability. Together with the transferable skills training, secondments and network, this will provide the doctoral candidates a strong basis for a successful career in industry or academia. The new scientific insights, engineering tools and educational programs to be developed within METRAMAT program will pave the way to wide-spread manufacturing and application of metamaterials in European industry, elevating it to the next level.

Keywords: mechanical metamaterials,vibration control,additive manufacturing,multiscale modelling and characterization
Biases in prospective learning and dynamic choice (PROSPECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1644025.0
EU funding (EUR): 1644025.0
Participants: 1
Project status: SIGNED

Many important economic decisions are made after individuals have had opportunities to acquire information. For example, investors can do research about the fundamentals of companies to estimate their future stock prices; consumers can read reviews before making purchase decisions; managers can experiment with different organizational structures before settling on one. As information acquisition is costly, decision-makers must evaluate its benefit ex ante by engaging in prospective learning, that is, by trying to predict the amount of information they will receive. PROSPECT aims to investigate experimentally whether individuals are able to correctly assess the benefits of future information acquisition, and to use this information proactively when making dynamic choices. The main objective is to uncover some potential fundamental biases in dynamic decision-making, such as a tendency to acquire too little information and to under-experiment relative to the rational benchmark. In Part 1, I aim to identify biases in prospective learning. The key question is whether individuals are able to correctly forecast the amount of information that a given real-life event reveals. Part 1a will study finance professionals’ ability to prospectively learn from market prices, and Part 1b will investigate whether the general population is able to extract information from past economic events to better predict future economic events. Part 2 studies how individuals take prospective considerations into account when solving dynamic decision problems. In Parts 2a and 2b, I will characterize whether they experiment as much as economic models predict they should, and study two candidate micro-foundations for insufficient experimentation. Part 2c revisits an old idea in behavioral economics, according to which prospective thinking is key to achieving self-control.

Keywords: beliefs experimentation information acquisition dynamic choice
Safe and sustainable by design microbial and lignin-based biosurfactants sourced from sustainable feedstock for home, personal care and agrochemical application (SURFs UP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Belgium,Germany,Estonia,Portugal,Finland,Spain,Italy,United Kingdom
Call: Development of scalable, safe bio-based surfactants, with an improved sustainability profile (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-05-01
End date: 2027-10-31
Duration (months): 42.0
Total project cost (EUR): 9325205.0
EU funding (EUR): 7396501.35
Participants: 12
Project status: SIGNED

Today only 4% of the surfactant market share consists out of compounds that are 100% based on biomass (fully bio-based surfactants or biosurfactants), while there is an urgent need for non-hazardous Safe and Sustainable By Design (SSbD) biosurfactants (BSs). The biosurfactant market is expected to grow at a CAGR of between 5.2 and 10.5% between 2022 and 2028. However the diversity of the currently available safe and sustainable biosurfactants is not at all sufficient to meet the market needs: diversity is key. The SURFs UP project aims to bridge this gap by demonstrating optimized and cost-efficient processes for 9 second generation (2G) SSbD biosurfactant products that will be formulated in prototypes in home- and personal care and agrochemical applications. The 2G feedstocks will include wood processing waste (sugars and lignin) and regional food/industrial (processing) waste. The 9 SURFs UP ingredients are: (1) 7 microbial biosurfactants, i.e. 2 drop-in sophorolipids, 2 new-to-market sophorolipid type biosurfactants, 1 new-to-market mannosylerythritol lipid and 2 new-to-market lipopeptides and (2) 2 new-to-market chemically produced BSs from lignin of wood processing waste. These ingredients will be fully characterized (physicochemical properties) and evaluated according to the SSbD Framework criteria and (eco)toxicity testing. The production of SSbD BSs will be scaled up (a.o. in the SURFs UP DEMO plant that will be built) and used to demonstrate prototype formulations in the aforementioned applications. Particular attention will be given to cost-efficient and sustainable production/use of the SSbD SURFs UP biosurfactants, evaluated within full TEAs and LCAs. Finally, SURFs UP will operationalize the EC SSbD Framework for the development of novel BSs and will work on all aspects considering social awareness and acceptance of these products via the organisation of consumer surveys, engaging stakeholders, policy makers and social media tools.

Keywords: biosurfactants,microbial,2g,lignin,sugar,bioprocess,fermentation,purification,home and personal care,agrochemical,biobased,demo plant,scale up,social acceptance,ssbd,formulation
Membrane Electrode Assembly for the High Pressure Electrochemical Conversion of CO2 to C2H4 (HIPECO2)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-09-01
End date: 2024-04-30
Duration (months): 20.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The electrochemical conversion of CO2 to chemical fuels is a promising technology for recycling CO2 and closing the carbon cycle. Amon the different products of the electrochemical reduction of CO2, multicarbon (C2+) product are more desirable because of their high energy density and high market price. Among them, ethylene is widely used for the production of raw materials and has a market price around 1000€/tons, which suggests relatively low threshold towards profitability. The development of such a technology to convert CO2 to C2H4 is however limited by the lack of selectivity and efficient catalysts to drive the reaction, while CO2 mass transportation to the active sites limits the conversion rate. During the course of our ERC-StG 2D-4-CO2, we have developed Cu-based electrocatalysts modified with aromatic functions, which demonstrated strongly improved selectivity for ethylene at industry relevant current density of 300 mA cm-2. The aim of the HIPCEO2 project is to apply the novel Cu-based catalyst develop in our group in a high-pressure membrane electrode assembly electrolyzer. Our specific goals are to realize a prototype with electrode size of 100 cm2 and verified stability of 1000 hours that will be used as a demonstrator to reach out potentials end-users and future partners.
A privacy layer to power all research and AI workflows (PrivacyForDataAI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 2100000.0
Participants: 1
Project status: CLOSED

Sarus will bring to market a privacy-preserving data solution for all research and AI projects. By leveraging generative AI and privacy research (differential privacy), the solution enables researchers and data scientists to leverage private data assets without seeing them. It acts as a protection layer between the data source and the scientist that guarantees the privacy of any computation. It supports a broad range of analysis, from analytics to AI, and blends effortlessly into existing workflows and IT infrastructures. Sarus bolsters data security and privacy, streamlines compliance processes, and unleashes the full potential of data for research and innovation. We have already demonstrated the potential and benefit of this approach with successful paid pilots with hospitals, healthcare organizations, financial services companies, and smart cities players. This projects will industrialize and robustify the solution, expand it to new forms of data and types of analysis (e.g.: LLMs) to support any data workflow in a privacy-preserving way. With Sarus, all data assets will be available to fuel innovation, growth, competitiveness, job creation, and societal progress without any compromise on citizens' fundamental rights.

Keywords: ai,research,privacy,security,data spaces,data protection,llm,generative ai,cloud,differential privacy,machine learning,analytics
Social Inequalities in Work-Family Strategies Within and Across 24 Industrialized Countries (WeEqualize)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1499146.0
EU funding (EUR): 1499146.0
Participants: 2
Project status: SIGNED

The gender revolution framework predicts a seemingly linear progression leading to a dramatic convergence in men’s and women’s roles in paid work and at home. Yet gender convergence appears stalled by conflicting structural and cultural factors across industrialized countries. Existing theoretical perspectives fail to simultaneously predict how the gender revolution shapes couple-level work-family patterns across countries and time for those with lower, middle, and higher socio-economic resources. WeEqualize will address the intertwined implications of the gender revolution—including changing gender beliefs, rising labor market insecurity, and the increasing retreat from partnerships—in shaping social inequalities in work-family strategies among different-sex couples across 24 countries from the 1960s to nowadays. WeEqualize will provide the first comprehensive characterization and quantification of social inequalities in work-family strategies across industrialized countries and over the long run. It aims to: identify a couple-level typology of work-family strategies; examine the prevalence of these strategies by education and across countries; evaluate the role of contextual factors in shaping work-family strategies; assess how historical and contemporary estimates of work-family strategies are shaped by changing demographic trends, and project future trends in work-family strategies for the coming decades; as well as collect and leverage new survey-based experimental data across different contexts to disentangle the role of gender beliefs from labor market constraints in shaping what type of work-family strategies couples choose and why. By combining innovative computational methods with multiple nationally representative studies, as well as collecting new survey-experimental data, WeEqualize will challenge and reframe our theoretical understanding of how gender equality progresses within and across families now and in the future.

Keywords: gender,work family,cross national,inequality,education,time use,couples