Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced technologies for zeroing in on high-grade gliomas (GlioZERO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,France,Serbia,United States,Japan
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 935438.57
EU funding (EUR): 791580.0
Participants: 11
Project status: SIGNED

Despite advances in diagnosis and therapy, glioblastoma (GBM) remains one of the most challenging cancers to treat, with overall survival under two years and a five-year survival rate of just 5%. This poor prognosis stems from three key factors: anatomical barriers, biological heterogeneity, immunosuppressive tumor microenvironment (TME). GlioZERO will establish a network of scientists with expertise in drug delivery, immunology, neurosurgery, robotics, and computational sciences to design microstructured polymeric films (microGRID) enabling deep, uniform, and sustained release of various therapeutic agents at the tumor margins; assess the efficacy of multimodal therapies in rigorous GBM models, leveraging microGRID to overcome anatomical barriers and systemic toxicity; improve surgical resection through intraoperative AI-assisted imaging; and employ advanced biological mapping to identify post-surgical TME alterations driving recurrence. To achieve these objectives, GlioZERO will bring together two EU Research Institutions, specialized in drug delivery, robotics, imaging (IIT) and brain cancer biology (Curie); two EU Enterprises, with expertise in neurosurgery (HUM) and computational modeling (BioIRC); four world-renowned US institutions advancing various therapies against GBM, including targeted therapies and immunotherapies (Stanford), oncolytic viruses (MD Anderson), anti-epileptic therapies (UCSF), and image-guided surgical therapies (BWH); and a Japanese partner (KU), focused on nano-therapies. Through interdisciplinary, intersectoral, and international secondments, GlioZERO will train a new generation of EU scientists, develop a novel class of drug delivery systems, and identify more effective therapies against GBM. Finally, partnerships with biotech accelerators in Silicon Valley, the Texas Medical Center, and the Greater Boston area will instill an entrepreneurial mindset and accelerate the clinical translation of GlioZERO discoveries and technologies.

Keywords: drug delivery,glioblastoma,medical imaging
THE WATERWISE HUB: AN EXCELLENCE HUB ON WATER IN THE CIRCULAR ECONOMY (WaterWise Hub)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Greece,Romania,Moldova, Republic of,Ukraine,Serbia,Albania,North Macedonia,United Kingdom,Netherlands
Call: Excellence Hubs (HORIZON-WIDERA-2023-ACCESS-07, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 5464843.75
EU funding (EUR): 5464843.75
Participants: 21
Project status: SIGNED

The WaterWise Excellence Hub is a vibrant, action-oriented initiative that aspires to serve as a catalyst for R&I (creation and uptake), business development, and knowledge dissemination for water in the circular economy (CE). It leverages CE principles to rethink and transform water management in Romania, Greece and selected Western Balkans and Eastern Partnership countries (MD, SB, AL, NM and UA). WaterWise perceives the water sector not only as sustainable, but also regenerative, emphasizing closed-loop systems, optimal resource use, and reduced waste, in line with EU policies and RIS3 strategies. It is based on a quadruple helix model of innovation, and works at the nexus of technology acceleration, entrepreneurial support and R&I, boosting water innovation in the Region and beyond. To this effect the Hub’s partners co-create an R&I Strategy, an Action and Investment Plan, a FundFinder Portal, a Strategic & Tactical Decisions Toolbox as well as an Operational Decisions Toolbox, setup Water Tech Challenges, develop and launch an Innovation Accelerator, produce LLL Training Courses, create and share a Knowledge Hub and develop and deploy a Mentoring Scheme through a bottom up approach in collaboration with a wide range of key actors and stakeholders across the region. The Hub is empowered by its strong partnership that brings together actors from government, R&I-driven universities and research centres, funding bodies, business, water utilities, SME associations and civil society to create services tailored for post-project sustainability and real-world impact.

Keywords: water innovation,circular and distributed water solutions,water in the circular economy,research to market,water innovation acceleration
Sustainability Performances, Evidence and Scenarios (SPES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Italy,Kenya,United Kingdom,France,Norway,Netherlands,Austria,Hungary,Serbia,Belgium
Call: Public policies and indicators for well-being and sustainable development (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 2677276.0
EU funding (EUR): 2677276.0
Participants: 12
Project status: SIGNED

The aim of the SPES project is to generate new knowledge and evidence about the nexus between economic growth, human flourishing and sustainability, contributing to the creation and uptake of a novel integrated framework fostering the transition towards the sustainable human development in European countries and regions. The SPES project focusing its attention, both theoretically and empirically, on the four pillars of the sustainable human development: a) Productivity, conceived as pursuing an efficient use of economic, human and natural resources through innovation processes; b) Equality for all, conceived as fostering equal political, economic, social and cultural opportunities; c) Sustainability, conceived as promoting climate change mitigation and adaptation and ensuring the protection, restoration and improvement of the environment; d) Participation and empowerment, conceived as enabling citizens, social groups and communities to be active agents of their future. Focusing on these four pillars allows both an in-depth analysis of their synergies and trade-offs, and their contribution to transition performances across Europe and the Global South. SPES will combine diverse methods, including 1) econometric analysis, including microsimulation and panel data analysis; 2) co-design workshops with key stakeholders; 3) scenario analysis; 4) case-study analysis The strong involvement of a carefully structured International Stakeholder Committee and of a Scientific Advisory Board, as well as the adoption of tailored communication, dissemination and impact Strategies, will decisively contribute to foster SPES impact. The newly produced policy and measurement framework will give further strengths to the transition towards sustainable human development by informing both the public debate and the implementation of existing policy frameworks, with a particular focus on the 2030 Agenda, the European Green Deal and the Just Transition Mechanisms, and the NextGeneration EU.

Keywords: sustainable human development development indicators sustainability transition inclusive growth post pandemic recovery just transition social progress 2030 agenda for sustainable development
Nano-Engineered Co-Ionic Ceramic Reactors for CO2/H2O Electro-conversion to Light Olefins (ECOLEFINS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Greece,Netherlands,Italy,Germany,Finland,United Kingdom
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 2519031.25
EU funding (EUR): 2519031.25
Participants: 8
Project status: SIGNED

As a major contributor to the global CO2 emissions, the commodity chemical industry should be urgently coupled with renewable electricity to become independent from fossil fuel resources. ECOLEFINS aims to establish a new, all-electric paradigm for the electro-conversion of CO2 and H2O to light olefins, the key-intermediates for polymers and other daily life chemical products. The proposed concept reverses the heavy CO2 emissions associated to the petroleum-based light olefins production to massive CO2 capture and valorisation for carbon negative ethylene, propylene and butylene. The concept introduces co-ionic ceramic membrane reactors and short-stacks/modules that merge the anodic steam electrolysis for hydrogen production with the cathodic CO2 electrolysis and hydrogenation to light olefins, over tailored and nano-engineered electrodes; aiming to develop a substantially more effective technology, for the single-step, RES-powered artificial photosynthesis of CO2 to valuable chemicals. This ambition entails a multi-disciplinary task, requiring highly tuned synergies among cutting edge research in the fields of: i) advanced materials science & engineering for co-ionic composites, perovskite ex-solutions, and organometallics, ii) electrochemistry and electrochemical process engineering, iii) catalysis science and engineering, iv) computer aided materials design and atomic scale modelling, and v) digital real-scale process modelling and economic evaluation, along with a comprehensive sustainability assessment, applied social research for impact framing, and marketization planning.

Keywords: h2o co2 co electrolysis,co2 hydrogenation,light olefins,chemical industry electrification,power2x,co ionic ceramics,nano engineering,exsolution,mofs,cofs,electrochemical membrane reactors
Breakthrough Early Breast Cancer Diagnostics (Giasay-Breast)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Slovakia
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Breast cancer (BC) is the most diagnosed cancer globally, with over 2.3 million women affected annually, leading to 670,000 deaths worldwide. In the EU alone, BC accounts for 13.8% of all cancer cases. The patient pathway in the diagnostic guidelines begins with regular self-check of the breast by the patient, followed by regular mammography, which is recommended usually from the age of 40 years on annual or bi-annual frequency. In case of younger women with dense breast, an ultrasound examination is recommended in some countries instead. If either of these results are suspicious, the patient is referred to undergo a breast biopsy. We introduces Giasay®-Breast, the first molecular diagnostic test based on glycan analysis for BC detection. Glycans, molecular signatures of cellular health, enable robust, accurate, and non-invasive diagnostics. Utilizing glycan-recognizing proteins (lectins) and a novel ELISA-like format, Giasay®-Breast provides exceptional clinical performance, analyzing serum samples with high specificity and sensitivity. Currently at TRL6, Giasay®-Breast has undergone extensive studies, validating its efficacy across BC stages and subtypes. With EIC Accelerator support, we aim to achieve clinical validation, CE/FDA certification, and validate the manufacturing process. Moreover, we will demonstrate significant cost saving for the healthcare system. Giasay®-Breast promises to revolutionize BC diagnostics, ensuring earlier detection, improved patient outcomes, and broader accessibility.

Keywords: oncology diagnostics,medical device,breast cancer,glycans,lectins,elisa
Commercialising a smart cardiac implant platform for the treatment of chronic cardiovascular disease (ALLIANCE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-06-01
End date: 2025-06-30
Duration (months): 25.0
Total project cost (EUR): 3999999.75
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Every year chronic cardiac disease causes 3.9 million deaths in Europe, that’s a death every 8 seconds. Overall chronic cardiac disease is estimated to cost the EU €210 billion/yr, in direct healthcare costs. All chronic cardiac disease patients are at high risk of stroke, atrial fibrillation, &/or heart failure The AuriGen platform is single minded in its focus on the leading causes of death in the developed world – Cardiovascular Diseases. Allowing more complex patients to be treated more effectively, and at a lower cost per patient. AuriGen’s platform of 4 devices is built around our custom cardiac implant, to which we can add synergistic modules such as cardiac monitoring, ablation or both modules. Creating devices which are much more than the sum of their parts, this our key USP. Allowing AuriGen to efficiently & effectively manage the most expensive & sub-optimally treated patients, in a single, safe, fast minimally invasive procedure.

Keywords: heart rhythm disorder,stroke,heart failure,atrial fibrillation,irreversible electroporation
Carbon Atlantis Project to Undo Residual Emissions - construction and deployment of a minimum viable product the Gen3 stack capable of capturing 500 tonnes CO2 per year from the air. (CAPTURE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 3563818.46
EU funding (EUR): 2494672.92
Participants: 1
Project status: SIGNED

Without carbon removal humanity will struggle to achieve carbon neutrality. The IPCC estimates that 6 gigatonnes of CO2 will need to be removed by 2050 to limit global warming to 1.5C. Bio-based solutions are relatively affordable, but have limited scalability. Technological solutions have recently been developed, but remain several orders of magnitude too expensive for mass market uptake. Carbon Atlantis have developed a breakthrough electrolyser that can decrease the costs of CO2 capture to below €75/tonne at megatonne scale. The objective of CAPTURE is to finalise the development of the third iteration of our technology (Gen3) and to deploy it in a demo plant. Successful deployment will validate the Gen3 500t-CO2/year minimum viable product in front of investors and customers, enabling us to raise funding to build out a mass manufacturing line. We aim for our devices to be capturing over 500,000t-CO2/year by 2030, with a vision is to remove 100 megatonnes of CO2/year by 2045.

Keywords: hydrogen electrochemistry,batteries and fuel cells waste management circular economy climatology and climate change environmental protection direct air capture carbon removal
The Asian Origins of Global Capitalism: European Factories in the Indian Ocean, 1500-1800 (CAPASIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2368600.0
EU funding (EUR): 2368600.0
Participants: 1
Project status: SIGNED

In the present age of de-industrialisation of the West, the origins and evolution of global capitalism matters. CAPASIA locates the origins of modern industrial capitalism in the space of Asian ports in the Indian Ocean, where the Portuguese, as well as the Dutch, English, French, and other European East India companies operated in the early modern period (1500-1800). Well before the rise of 20th-century Special Economic Zones and world financial centres, the ports of maritime Asia (‘factories’) were areas of global trade and hubs of economic dynamism. Today ‘factories’ are places of industrial production, but they owe their name to these pre-modern Asian trading ports, European-controlled trade hubs headed by company servants called ‘factors’. Factories were places where commodities for intercontinental trade were assembled, stored and shipped. This project investigates the genesis, evolution, activities, and connections of over 150 small and large such factories as the foundation for a new spatial theory of capitalist development — complementing and challenging the current Atlantic plantation-based explanations proposed by the New History of Capitalism. CAPASIA’s integration of the large archival repositories of the different European East India companies and Asian archives will also be the basis for the ‘decolonization’ of the history of capitalism. Over its five-year duration, this project will ask: what kind of economic activities were carried out in these imperial trading centres? What were the interactive roles of European and local merchants? It will map the intercontinental movement of goods, people and information across an ‘archipelago’ of Asian ports. Working with collaborators from across the globe, CAPASIA’s overarching ambition is to recast the narrative of global economic change and capitalism by incorporating both Asian and European economic actors, and their interactions, in the space of the still unstudied factories of the Indian Ocean.

Keywords: history of capitalism factories early modern global history trade east india companies production
AI-SUSTAINABLE AND EFFICIENT BRIDGE ENGINEERING WORLWIDE (AI-SEBEW)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

BERD, a distinguished SME with over 17 years of experience, excels in the research, development, and implementation of innovative solutions for bridge and viaduct construction. Founded within an academic environment by Professor Pedro Pacheco, BERD combines deep scientific knowledge with a market-oriented approach, resulting in high-value, cutting-edge solutions. The company's primary focus includes the design, manufacture, and supply of bridge construction equipment and modular bridge solutions, with a strong international presence across five continents. The proposed project, AI-SEBEW, aims to revolutionize the bridge construction industry by addressing two key problems: inefficiencies in preliminary design and budgeting, and the significant environmental footprint of this industry. Current budgeting processes are time-consuming and prone to errors, leading to cost overruns and project delays. AI-SEBEW leverages advanced AI and analytical tools to automate budgeting, reducing the time required from several months to just a few hours, providing precise cost estimates, and offering a broader range of efficient and sustainable construction solutions. AI-SEBEW's innovative Software as a Service (SaaS) will streamline bridge design and budgeting, enhancing efficiency, reducing costs, and minimizing environmental impact. The system integrates a comprehensive "Bill of Quantities" with engineering and cost engines driven by context vectors, ensuring accurate and reliable results. This holistic approach will also significantly reduce CO2 footprints and optimize resource allocation. BERD seeks €17.5 million in funding, including €2.5 million in grant and €15 million in investments, to further develop and scale-up AI-SEBEW. The project's successful commercialization will transform the bridge construction industry, delivering substantial societal, environmental, and economic benefits, aligning with the European Green Deal and other EU policies.

Keywords: bridge engineering software as a service saas bridge budgeting sustainability,scheme design,construction planning artificial intelligence advanced analytics efficiency cost reduction
Aligning Life Cycle Assessment methods and bio-based sectors for improved environmental performance (ALIGNED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Denmark,Netherlands,Belgium,Spain,France,Switzerland,Norway,Portugal
Call: Increasing the environmental performance of industrial processes in bio-based sectors: construction, woodworking, textiles, pulp and paper and bio-chemicals (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3718076.25
EU funding (EUR): 3718075.0
Participants: 15
Project status: SIGNED

The ALIGNED project will deliver a modelling framework to assess and optimise the environmental and socio-economic performance of bio-based industries. ALIGNED will advance the scientific field of Life Cycle Assessment (LCA) (moving from TRL2-3 to TRL5) and collaborate with industries and representatives from five bio-based sectors: construction, woodworking, textile, pulp and paper, and bio-chemicals. The transition towards a sustainable economy is dependent on consistent and comparable environmental assessments of bio-based products. However, in practice today the methods to assess the impact of bio-based products give incomparable results, thus confusing decision-making. The models and tools developed in ALIGNED will allow to perform high-quality assessment studies across the bio-based sectors, with industrial relevance and interoperability. This is possible by the iterative application and improvement of the new and harmonised models and tools in six specific cases of bio-based industrial technologies (TRL 2-6). The ALIGNED framework will allow accurately to model key aspects not covered in current practice: the competition for biomass and for land, dynamic and time-specific carbon accounting, and biodiversity and socio-economic impacts. ALIGNED will also develop future energy and resource scenarios derived from integrated assessment models, and a consistent approach to uncertainty assessment. Key stakeholders in the five sectors will be continuously involved, by providing feedback in the early framework development and by sharing the learnings from its practical application. The professional engagement of stakeholders will secure industry relevance and acceptance delivering real impact.

Keywords: life cycle assessment sustainability global warming potential biodiversity socio economic impact iluc landuse