Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Computational Microscopy of Crowded Membranes (COMP-MICR-CROW-MEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2020-10-31
Duration (months): 60.0
Total project cost (EUR): 2396584.57
EU funding (EUR): 2396584.57
Participants: 1
Project status: CLOSED

Cell membranes form a highly complex and heterogeneous mixture of membrane proteins and lipids. Understanding the protein-lipid interplay that gives rise to the lateral organisation principles of cell membranes is essential for life and health. Thus, investigations of these crowded membranes is emerging as a new and exceptionally exciting frontier at the crossroads of biology, life sciences, physics, and chemistry. However, our current understanding of the detailed organisation of cellular membranes remains rather elusive. Characterisation of the structural heterogeneity in-vivo remains very challenging, owing to the lack of experimental methods suitable for studying these fluctuating nanoscale assemblies of lipids and proteins with the required spatio-temporal resolution. In recent years, computer simulations have become a unique investigatory tool for understanding the driving forces governing the lateral organisation of cellular membrane components and this “computational microscopy” has become indispensible as a complement to traditional microscopy methods. In this ERC project I will, using advanced computational microscopy, study the interaction of lipids and proteins in complex, crowded, membrane patches, to enable the driving forces of membrane protein sorting and clustering to be unravelled at conditions closely mimicking real cellular membranes. The specific objectives are: • To develop a novel computational microscopy framework for simulating biomolecular processes at multiple resolutions. • To use this new computational microscopy framework to investigate the driving forces of membrane protein sorting and clustering. • To provide a molecular view of realistic, crowded, biological membranes composed of hundreds of different lipids and proteins. The outcomes will enable subsequent studies of many different types of cell membranes based on forthcoming lipidomics studies and progress in structural characterisation of membrane proteins.

Keywords: biomembranes,molecular dynamics,multiscale modelling
High-performance, affordable super-resolution platform for the life sciences (Resolve)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-07-01
End date: 2019-12-31
Duration (months): 18.0
Total project cost (EUR): 149187.0
EU funding (EUR): 149187.0
Participants: 1
Project status: CLOSED

Since their invention, super-resolution microscopy approaches are starting to transform research in the life sciences by enabling spatial resolution below the classical diffraction limit of light. In order to establish super-resolution microscopy as a standard research tool in the life sciences, researchers need to be able to readily access the three main technological pillars of super-resolution microscopy: instrumentation, software, and labeling probes. To date, the instrumentation is typically a very costly and complex microscope that requires skilled personnel for its operation. The software is either a non-user-friendly, but freely available solution, or a pricey commercial option that comes together with the costly microscope. Finally, the commercially available labeling probes so far suffer from several shortcomings in terms of performance and their multiplexing capability. During the ERC-funded project MolMap, we developed novel solutions for all three technological pillars. We constructed a prototype for an affordable super-resolution microscope with an estimated cost of only a fraction of the price of currently available commercial options. In addition, we developed a novel and user-friendly software platform as well as customizable labeling probes for sequential imaging of a multitude of targets. Together, these developments have the potential to be integrated into a high-performance and affordable super-resolution platform to become standard in life science laboratories such as nowadays cell culture microscopes. The aim of this Proof-of-Concept proposal is to further optimize the three technologies and to adapt the fully integrated platform to market needs.

Keywords: super resolution microscopy,dna nanotechnology,single molecule biophysics,multiplexing,fluorescence labeling,immunolabeling
HUMAN AIRCRAFT ROADMAP FOR VIRTUAL INTELLIGENT SYSTEM (HARVIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Italy,Spain,France
Call: Cognitive Computing potential for cockpit operations (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 826500.0
EU funding (EUR): 826500.0
Participants: 4
Project status: CLOSED

The overall objective of HARVIS project is to identify how cognitive computing algorithms implemented in a digital assistant could support the decision making of a single pilot in complex situation. A roadmap will be produced in order to help the EU and CS2 JU in their work of influencing the research and development funds in the next decade.
Shaping the conflict: The role of judicial and humanitarian forensic knowledge in co-producing collective accounts of violence. A case study of the Colombian (post) conflict (Shaping the conflict)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-09-07
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Social and academic inquiry on post-conflict societies has focused on victims and perpetrators with a recent interest in forensic specialists as expert witnesses. Yet the way forensic knowledge about life, death, bodies and evidence impacts on our understanding of conflict and violence has been overlooked. Two reasons for this are that forensic knowledge is: 1) mainly seen as a practice that produces neutral scientific evidence; 2) mostly considered part of the judicial system (helping to solve crime and administering justice), leaving the recent work of humanitarian forensics (identifying victims of war with no intention at judicialising perpetrators) unattended. Through an ethnographic approach to the forensic process of identification I will examine how judicial and humanitarian forensic experts’ differentiated knowledge co-shape accounts of conflict and violence. And in a context of transitional justice, they give format to actions towards victims’ reparation and the administration of justice. I will address these issues through the case study of the ongoing Colombian (post-)conflict. Its multifaceted characteristics and the fact that currently, humanitarian and judicial forensic experts are both, yet separately trying to account for the conflict, provides a rich case, potentially contributing to the study of violence and conflict elsewhere. This project relies on conceptual frameworks from the anthropology of science, social studies of forensics, and transitional justice studies. It combines research tools of these areas with some of critical design. Outcomes include an exhibition showcasing results, a workshop with multiple audiences, and written pieces. This proposal includes the transfer of knowledge to the host institution and my training in advanced techniques and theories in (co)supervision of graduate students, in teaching abilities, and outreach activities. All activities will maximise my future employability as a scholar in the European research area.

Keywords: forensic specialists knowledge,world making practices,forensic turn,conflict and post conflict,transitional justice
THE EUROPEAN UNIVERSITY OF SOCIAL SCIENCES - RESEARCH AND INNOVATION (CIVICA RESEARCH)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Austria,Germany,Italy,Italy,Romania,Sweden,France,United Kingdom
Call: Support for the Research and Innovation Dimension of European Universities (Part I) (H2020-IBA-SwafS-Support-1-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1951951.37
EU funding (EUR): 1951951.37
Participants: 8
Project status: SIGNED

CIVICA RESEARCH aims at endowing CIVICA, the European University in Social Sciences, with the instruments of an ambitious and innovative research strategy. CIVICA RESEARCH will explore major institutional transformations to operate a paradigm shift in several key-sectors in a way to: design a strategic research agenda, reinforce human capital and facilitate brain circulation, implement an Open Science culture, create and remove obstacles to shared research ecosystems. CIVICA RESEARCH aims to achieve optimal transnational cooperation among its partners. The keystone of this strategy are the four central issues to be tackled by all our disciplines: Democracy in the XXIst Century; Societies in Transition and Crises of Earth; Europe Revisited; Data Driven Technologies for Social Sciences. The project will use a wide array of events, infrastructures, and tools to enable each researcher within CIVICA to contribute to our collective elicitation of the joint scientific activities developed around these four priorities. We will bring projects up from the grassroots following a multi-pronged approach. 1) Rapid setup of snowball seminars, pilot calls and hackathons will contribute to build-up a common work plan. 2) Innovative mechanisms that facilitate the circulation of scholars and ideas within the Alliance will spur the emergence of a CIVICA scientific community. The project also features tools to ensure that outside scholars become familiar with CIVICA identity. 3) We will develop research infrastructures (e.g online experimental lab), that fully exploit the potential of digital tools for research. 4) We aim at producing influential knowledge that percolates beyond academic circles, thus setting joint high standards in terms of Open Science practices. 5) We devote significant resources towards the dissemination and communication of our research to targeted audiences. A Rapid Policy Response Mechanism aims in particular to enhance our collective outreach to policymakers.

Keywords: institutional change,research strategy,climate change,democratic erosion,digital revolution,european construction,digital research infrastructures,informing policymaking
The retinae as windows to the brain: An oscillatory vision (OscillatoryVision)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2016-03-01
End date: 2022-03-31
Duration (months): 73.0
Total project cost (EUR): 1499850.0
EU funding (EUR): 1499850.0
Participants: 1
Project status: CLOSED

Several sophisticated image processing circuits have been discovered in the animal retina, many of which manifest massive neural synchrony. A major insight is that this type of synchrony often translates to high-frequency activity on a macroscopic level, but electroretinography (ERG) has not been tapped to examine this potential in humans. Bolstered by our compelling results combining ERG with magnetoencephalography (MEG), this project will address several open questions with respect to human visual processing: 1) Could variable retinal timing be linked to intrinsic image properties and pass on phase variance downstream to visual cortex? Our data suggests the retina responds to moving gratings and natural imagery with non-phase-locked high gamma oscillations (>65 Hz) just like visual cortex, and that slower ERG potentials exhibit strong phase-locking within stimuli but large phase variance across stimuli. 2) Do such retinal gamma band responses, both evoked and induced, directly drive some cortical gamma responses? Pilot data suggests that it can, through retinocortical coherence, our novel ERG-MEG mapping technique. 3) Several kinds of motion have now been shown to elicit massive synchrony in mammalian retina circuits. Does this also result in macroscopic high-frequency activity? If so, our experiments will finally reveal and characterize motion detection by the human retina. 4) Do efferent pathways to the retina exist in humans? We discovered that the ERG exhibits eyes-closed alpha waves strikingly similar to the classic EEG phenomenon and, leveraging our retinocortical coherence technique, that this activity is likely driven by contralateral occipital cortex. Then, can retinal responses be influenced by ongoing cortical activity? Characterizing retinocortical interaction represents a complete paradigm shift that will be imperative for our understanding of neural synchrony in the human nervous system and enable several groundbreaking new avenues for research.

Keywords: gamma band,neural synchrony,induced oscillations,neural connectivity
Digital Nudges, Incentives and Social Influence in Habit Formation of a Global Health Behaviour (NISIHealth)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2022-02-02
Duration (months): 24.0
Total project cost (EUR): 163648.8
EU funding (EUR): 163648.8
Participants: 1
Project status: CLOSED

The lack of physical activity is a leading cause of preventable death globally. For most people, failure to exercise is unlikely to be due to ignorance or lack of interest. While individuals are frequently motivated to start exercising in order to reduce and reverse different health risks, they often encounter difficulties in forming a sustained behavioral change--a habit. Habits are behaviors repeated in the same setting. They are characterized by activation by recurring context cues, insensitivity to short-term changes in goals, and other markers of automaticity. This action aims: A. to develop information-theoretic measures of regularity and predictability in fitness behavior which can be used as new measures of habits that better predict future retention, B. to understand the role of digital nudges and economic incentives in fitness habit formation and C. to investigate how social influence enhances individual habit formation in the age social media. To assess these research questions, the fellow -- in collaboration with a global exercise tracking company -- will device methodologies currently used in information theory and statistics on large scale historical individual datasets of fitness activity. In addition, the action will make extensive use of surveys and high fidelity randomized control experiments to validate empirical results and establish causal relationships. The complementarity between the expertise of supervision and the fellow’s qualification as well as the arrangements and environment provided by the host institution guarantee the success of this groundbreaking and timely project as well as an effective dissemination and utilization of the expected outcome. The conclusions of the proposed action could have important implications to health agencies in European Union and around the world, and may shape the way public health policy is imposed.

Keywords: social networks,digital media,human behavior,habits,social influence,nudges,economic incentives,randomized experiments,natural experiments,causality,big data,data analytics,fitness,health
Lead free automotive SLI power (LEFAPO)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Czechia
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-2-2015, 2015)
Start date: 2015-12-01
End date: 2018-08-31
Duration (months): 33.0
Total project cost (EUR): 3608500.0
EU funding (EUR): 2525950.0
Participants: 1
Project status: CLOSED

This project contributes to the call’s overall objective, which is to stimulate the competitiveness of eco-innovative SMEs seeking to launch their products on world markets. This project introduces an eco-innovative product, a car-starting battery, which contains no hazardous materials, extends battery life at least six times longer (in start-stop life) compared to lead-acid batteries, and produces significant CO2 savings. Olife has developed a new car battery that is a milestone in the evolution of the automotive industry. It is the first full substitute for lead-acid batteries and offers many advantages, such as: superb performance, light weight, high range of operating temperatures, ideally suited to start-stop systems, superior reliability and durability, resistance to extreme vibration, starting ability up to 90% DOD (depth of discharge), lead and acid free, non-hazardous and eco-friendly. The business innovation project aims to complete the development and to demonstrate industrial readiness and maturity for primary market introduction (the new vehicle market), to build brand awareness, develop communication and dissemination activities for both the primary market and the aftermarket. This objective will be accomplished via three key steps: 1) Testing, modification and finalisation of product development for OEM market 2) Communication and dissemination activities 3) Protection of intellectual property The current battery market, due to LAB (lead-acid battery) technology limitations, offers a wide variety of batteries of different capacities. Olife's offering (L2 and L5) successfully meets major market requirements. • The L2 Olife battery is equivalent to a 55Ah LAB battery. • The L5 Olife battery is equivalent to a 110Ah LAB battery. Patent applications have been already submitted in the 120 countries. In Mexico and South Africa, a patent has already been obtained. In other countries, patents are pending.

Keywords: eco innovative project,starting car battery,substitute for lead acid batteries,no hazardous,materials,extends battery life,significant co2 savings,supercapacitor,li ion
Renewable and Waste Heat Recovery for Competitive District Heating and Cooling Networks (REWARDHeat)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Germany,Austria,Germany,Germany,Spain,Spain,Italy,Italy,Spain,Germany,Italy,Belgium,Croatia,Poland,Poland,Romania,Sweden,Croatia,Sweden,France,France,France,Netherlands,Netherlands,Denmark,Denmark,Denmark
Call: Combining Renewable Technologies for a Renewable District Heating and/or Cooling System (H2020-LC-SC3-2019-RES-IA-CSA, 2019)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 18718100.38
EU funding (EUR): 14999481.629999999
Participants: 35
Project status: SIGNED

It is in urban areas that the demand for heating and cooling demand assumes highest density. At the same time a huge amount of low-grade waste heat is diffused within the urban texture, the largest amount being rejected by air-conditioners, cooling systems in industrial processes and tertiary buildings (i.e. dry coolers and wet cooling towers), datacentres’ chillers and supermarkets’ refrigeration systems. Moreover, for historic reasons, cities have born along rivers, lakes and seashores. All these sources make low-temperature renewable energy available, which utilisation is highly replicable because it is accessible right where it is needed. Having this in mind, the overall objective of REWARDHeat is to demonstrate a new generation of low-temperature district heating and cooling networks, which will be able to recover low-grade renewable and waste heat available at low temperature. Focusing on the exploitation of the energy sources available within the urban context allows to maximize the replicability potential of the decentralized solutions developed in the project. REWARDHeat will promote punctual metering, thermal storage management, network smart control as means to enable and optimise the exploitation of renewable and waste heat in DHC networks. At the same time, this approach permits a change of paradigm with respect to the business models devised: thermal energy will not be seen as a commodity anymore, rather it will be sold as a service to the customers.

Keywords: geothermal energy,waste heat,district heating and cooling,digitalisation,sector coupling