Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cooperative Water and Renewable Energies Management (COOPWEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-04-01
End date: 2011-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

COOPWEM directly goes back to the research needs identified during the implementation of the Marie-Curie project MTKD-CT-2004-014312 that has been implemented in CEIFA mostly under the scientific coordination of Mrs Suhita Osório-Peters. She was one of the guest researchers who joined our institution with a Marie-Curie stipend (Sept 2005 – Aug 2007). Before, she had more than 10 years full-time experience as a researcher in Germany. Her academic background is economics with a post-graduation in environmental sciences. She has excellent communication, coordination and leadership skills, and she really ‘thinks’ interdisciplinary. Our experience with her was excellent. Now, we jointly apply for a reintegration grant, in order to promote the framework conditions that ensure long-term job stability to Mrs Osório-Peters in our institution. COOPWEM is a research project with a duration of three years that addresses very topical issues and emphasizes an integrated approach of three complementary research areas: a) new instruments for the management of natural resources, b) local innovation systems and c) solidarity economy. By means of participatory approaches, it addresses the hypotheses that institutions based on cooperative arrangements are key elements of local innovation systems; still, the economic benefit of community based institutions is particularly important in the management of natural resources. It will focus on the analysis of the framework conditions that promote (or hinder) the implementation of new instruments in the field of natural resources management in Portugal. In particular, it will analyse the role of water users’ associations (WUA), as well as that of small scaled energy producers’ cooperatives, for sustainable regional development. Since CEIFA wants to enlarge its service offer into the areas of water and renewable energies management, COOPWEM perfectly links Mrs Osório-Peters own career development plan with the strategic goals of our enterprise.

Keywords: ecological economics,integrated management of water,renewable energies,rational use of energy in buildings,social economics
Air-Sea Fluxes of Climatically Relevant Gases in the Marine Atmospheric Boundary Layer (AIRSEA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Climate change is one of the greatest environmental challenges today, with the potential to significantly alter how we live. It is largely attributable to human activity where greenhouse gases (GHG) are released into the atmosphere. The oceans exert a considerable influence on the atmosphere by absorbing a large fraction of GHGs, but there remain large uncertainties in the budget. This underscores the importance of conducting research concerned with air-sea gas fluxes in order to work toward a reduction in these uncertainties. The scientific objectives of this proposal are to simultaneously measure the fluxes of climatically relevant compounds in both the coastal and oceanic marine atmospheric boundary layer. The proposed species are carbon dioxide, methane, nitrous oxide, and carbon monoxide. All species will be detected at 1-10 Hz, which will allow for fluxes to be directly determined using the eddy correlation method. This proposed method takes advantage of recently-developed trace gas analyser (TGA) technology. The TGA will be deployed at the Mace Head Research Station where a time series over several years will be acquired. The system will also be deployed periodically on research ships to compare the magnitude of the fluxes in the coastal regions with open ocean data. If funded, this measurement will be one of the first of its kind deployed in the marine atmospheric boundary layer, and will provide an invaluable time series of the fluxes over an extended period. The Returning Research Fellow (RRF) for this proposal has spent the previous 7 years as a fulltime researcher in the field of air--sea exchange in the USA, where he has established a level of excellence in gaining funding and conducting research. Funding from the IRG programme will allow the RRF to establish a research programme in Europe, with the objective of fully integrating into the European Research Area.

Keywords: physical oceanography,observation systems (climate change),greenhouse gases (climate change)
Realistic dense matter physics and numerical simulations of compact star spacetimes (DYNEOS2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-04-01
End date: 2011-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The ultimate goal of this project is to explore, by theoretical considerations and numerical calculations, the mysterious and presently at large unknown interiors of compact astrophysical objects. Comparison of theoretical results with observations will allow for putting constraints on the properties of extremely dense matter, which is not likely to be accomplished in Earth-based experiments in near future. This intrinsically multidisciplinary project demands to combine knowledge from various fields of physics of different scales, especially the General Theory of Relativityand the modern theory of dense matter (quantum mechanics, thermodynamics, nuclear physics, theory of super-fluidity...), astrophysics as well as applied mathematics (numerical algorithms) and advanced programming in order to use and develop numerical methods for solving multi-dimensionalcomputational problems than cannot be solved analytically. The Applicant will address, through careful research and development of state-of-the art numerical libraries, a broad range of interesting unsolved astrophysical problems, such as the state of differentially rotating compact stars, oscillation and stability of non-linear modes for rapidlyrotating stars, dynamical re-configuration of the star structure induced by the appearance of exotic phase core (so-called mini-collapse), inclusion of realistic processes (i.e. viscosity, magnetic fields), elastic and thermal properties of the crust of spinning-down pulsars as well as direct computation of resulting gravitationalwave emission in various physical settings. The Applicant plans also to allocate a part of the time to explorecompletely new numerical approach, namely wavelet methods for solvingpartial differential equations: this approach unites the locality of finite-differences methods and the accuracy and theoretical foundations of spectral methods and therefore seems ideal for realistic astrophysical simulations.

Keywords: physical sciences,astrophysics,computational physics,relativity,nuclear physics
Optical Difraction Tomography in Particle Image Velocimetry (ODTIPIV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-03-10
End date: 2011-03-09
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Holographic Particle Image Velocimetry (HPIV) has been used successfully to make three-dimensional (3D), three-component (3C) flow measurements from holographic recordings of a seeded fluid. It is clear that measurements can only be made in regions that contain particles, but simply adding more seeding results in poor quality images due to the effects of multiple scattering. Optical Diffraction Tomography (ODT) techniques have been successfully applied to overcome the problems of multiple scattering in 2D HPIV numerical experiments by the applicant in the previous Marie Curie Intra European fellowship. The aim of this proposal is to implement these techniques for the measurement of 3D-3C velocity fields for the flow inside a few millimeter length aneurism model. The results will be compared with HPIV and Digital Holographic Image Plane interferometric measurements.

Keywords: metrology,applied optics
Classifying the conjugacy relation of the group of C2 diffeomorphisms of the unit circle, and characterizing isometry groups of separable ultrametric spaces. (REDUCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-04-01
End date: 2011-08-01
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The first part of the project is concerned with a classification of the orbit equivalence relation E coming from the conjugation action of the group of all diffeomorphisms of class C2 on itself. A well-known example given by Arnold shows that there exist C2 diffeomorphisms of the circle with equal rotation numbers, which are not conjugate by any smooth mapping. This raises a natural question as to how complicated relation E is. Methods coming from Borel reducibility theory will be used to estimate lower and upper bounds for complexity of E. In particular, the following problems will be studied. Is E essentially more complicated than the identity relation? Is D reducible to an equivalence relation with countable equivalence classes? Can D be classified by the isomorphism relation on a class of countable models? The second part of the project is a continuation of a line of research initiated by Gao and Kechris. It is devoted to studying Polish ultrametric spaces, that is, metric spaces satisfying a strong version of the triangle inequality, and their isometry groups. A structure theorem, proved by the executioner of the project, representing each separable ultrametric space as a 'bundle' with an ultrametric base and with homogeneous fibers will be further investigated. Its detailed study and analysis of the limit behavior of involved quotient maps will be used to characterize Polish ultrametric spaces and their isometry groups. This will provide an answer to a question posed by Gao nad Kechris. The implementation of the project will allow the executioner of the project to develop a solid research portfolio in a lively developing field of mathematics, contributing in this way to their lasting reintegration, and to European scientific excellence.

Keywords: polish groups,isometry groups,ergodic theory,descriptive set theory,equivalence relations,ultrametric spaces
Identification of the protein binders of the androgen receptor BF3 pocket, an allosteric modulator of AF2 coactivator recruitment (AR BF3 BINDERS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2009-02-01
End date: 2013-01-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The androgen receptor (AR) is a nuclear receptor (NR) that plays a central role in prostate cancer. The transcriptional activity of AR can be modulated though a newly described regulatory surface on its ligand binding domain (LBD). We call this surface BF3 (binding function 3), and I discovered it during my postdoctoral research. So far the only coregulatory proteins described are able to regulate AR activity by binding to the coactivator binding pocket (AF2), which is also located on the LBD surface. Both pockets, AF2 and BF3, are physically connected. In my numerous molecular structures of the AR LBD solved by Xray crystallography, I have been able to see that BF3 is an allosteric modulator of AF2. BF3 is able to influence whether coactivator proteins are correctly recruited to AF2 to start the transcriptional cascade of AR-dependent genes. Thanks to my discovery of several BF3-interacting chemical compounds we have been able to determine which conformational changes are propagated from BF3 to AF2 impairing AR activity. Such small molecules are an important starting point for structure-based drug design to identify novel AR regulators that may be used as new treatments for prostate cancer. I have also investigated what effect mutations in BF3 have on AR transcriptional activity. The topology, localization, and physico-chemical properties of BF3 indicate that it is a bona fide pocket for protein-protein interactions and it may have a physiological regulatory action on AR function in vitro and in vivo. The identification, characterization and crystallization of BF3-interacting proteins and their crystal structure determination alone or in complex with AR are the main objective of my future research. Such proteins may be a novel class of AR coactivators in particular, or coregulators of other steroid NR. These studies are relevant to the NR and for the pharmaceutical fields, as BF3-binders may be novel targets to alter AR function in prostate cancer.

Keywords: health sciences
Educational, Scientific, and Technological Aspects of Splines (ESTSPLINE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Estonia
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-05-01
End date: 2011-04-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Having completed a two-year senior researcher fellowship as part of the Marie Curie Transfer of Knowledge (ToK) project CENS-CMA, the proposing researcher, Dr. Ewald Quak, has elected to stay at the fellowship host institution CENS and pursue his further career while located in Estonia. The ToK project CENS-CMA (Collaboration of Estonian and Norwegian Scientific Centres within Mathematics and its Applications) joins the Estonian National Centre of Excellence CENS (Centre for Nonlinear Studies) and the Norwegian National Centre of Excellence CMA (Centre of Mathematics for Applications). The still-ongoing CENS-CMA project is a collaborative effort concerning research in computational mathematics, but also in training and public outreach activities. Though no longer financed by that project, Dr. Quak will continue to serve as an important link between the two centres and contribute to their activities, being familiar with CENS now (as a member of CENS since May 2005) and having worked for the Norwegian non-profit applied research organization SINTEF since 1996, and a member of CMA since its inception in 2003. Dr. Quak's research in the use of spline functions as tools in computational mathematics will cover various aspects: new scientific work in the stability and use of spline wavelets as part of a multiresolution analysis; technological applications concerning water waves, especially in a newly defined CENS activity called "Green Marine Highways" to reduce the damage caused by oil pollution in the Baltic Sea; educational initiatives such as publishing books on related topics, developing coursework, also in the framework of the European Consortium of Mathematics for Industry, and continuing to organize joint industry-academia workshops and other events to stimulate intersectorial contact.

Keywords: computational mathematics,applied mathematics,numerical analysis
Radio pulsars with LOFAR: a study of extreme physics laboratories. (PULSARS WITH LOFAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-05-01
End date: 2012-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A radio pulsar is formed when the iron core of a massive star collapses in a supernova explosion. Due to their extreme compactness and supernuclear density radio pulsars are extremely stable rotators. Our goal is 1) to use radio pulsars to improve our limited understanding of some of the most energetic events known in the universe and the source of the elements that make up planets and all forms of life: supernovae 2) to find individual radio-pulsar systems that are such stable rotators that they can be used for the first-ever direct detection of gravitational waves or in the first ever strong-field test of gravity. We can do this with LOFAR, a revolutionary new radio telescope that host institute ASTRON is currently completing. LOFAR has more collecting by itself than all other radio telescopes in the world combined. In the course of his research in the US, van Leeuwen has acquired the radio-telescope survey experience, the instrument-development skills and the pulsar-population knowledge that will be needed for this project to push the boundary of our understanding of the universe. As the host institute is close to completing the most sensitive radio telescope in the world, the researcher will have unsurpassed means to accomplish the objectives laid out above. The host institute offers the researcher a tenure position in its scientific staff where he can be at the global forefront of telescope possibilities for the next decade. We expect to foster several intense decade-long EU-US co-operations between the host and the researcher's current US collaborators and Berkeley group to 1) adapt algorithms, monitor new discoveries and improve supernova modelling; and 2) design and build several leading-edge signal processing machines. For the next decade this project can define the global scientific and technological state-of-the-art within its field.

Keywords: astrophysics,neutron stars
Vesicular Golgi trafficking deficiencies in unsolved CDG type II patients (VTG-CDG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-05-01
End date: 2011-04-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Glycobiology is considered as an emerging field of biology and the importance of complex carbohydrates in health and disease is increasingly recognized. In the last decade, a new group of diseases related to defects of glycosylation and called Congenital Disorders of Glycosylation has been identified. According to the cellular localization of the deficiency, CDG can be divided into two groups, CDG-I and CDG-II. Group I disorders relate to defects in the synthesis of the N-glycans in the endoplasmic reticulum. This project relates to Group II disorders, which arise from the defects in the processing of the glycans, mainly in the Golgi apparatus. Whereas all known CDG cases so far have defects in genes encoding proteins directly involved in the glycosylation process, our previous works highlighted that more cases may be linked to a defect of intracellular trafficking within the Golgi apparatus. This greatly expands the number of potential candidate genes and the proposed research aims at identifying new unsolved CDG-II patients with a trafficking deficiency in which localization and/or trafficking of Golgi associated glycosyltransferases appears disturbed. The first part of the project will be devoted to the screening of unsolved CDG-II patients for trafficking deficiencies and the second part will concern the identification of a new gene causing a new type of CDG with significant neuromuscular involvement. Indeed, we recently identified two patients in two different families with CDG and a very specific phenotype that includes myopathy, encephalopathy and epiphyseal hypoplasia. However and surprisingly, it appears that the patient cells also display a trafficking deficiency. We will aim to demonstrate the pathogenic nature of the unusual, homozygous mutation that we have identified in this gene, and prove its involvement in both glycosylation and trafficking deficiencies. Using the zebrafish model, we will next try to unravel its role in the development.

Keywords: glycobiology,inborn errors of metabolism,rare diseases,golgi trafficking,rare diseases
The role of intracrine receptor-ligand interactions in survival of disseminated breast cancer cells (META-BREAST-CA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-12-01
End date: 2012-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Breast cancer is the most common cancer in women and, after lung cancer, the second leading cause of cancer-related deaths. The most important factor influencing the outcome of patients with an invasive cancer is whether the tumour has spread regionally or systemically. Breast cancer dissemination is a multi-step process, affected by intrinsic, as well as by microenvironmental factors. Metastases start out as single cells that detach from the primary tumour and travel to distal locations. The number of circulating tumour cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer. The biology of these cells is not well comprehended and its understanding is critical for therapeutic improvements. One of the key questions that remain to be fully resolved is what molecular events allow the survival of cancer cells in hostile environment of peripheral blood. Recently, a novel concept arose redefining the molecular basis of survival of breast cancer cells. According to this concept, tumour cells can utilize intracellular (intracrine) receptor-ligand interactions to produce signals necessary for tumour survival under unfavourable conditions. A major scientific objective of the proposed project is to generate, using a transgenic approach, the animal model systems of breast cancer allowing to study the role of intracrine signalling in survival of disseminating breast cancer cells. The work activities detailed in this proposal will have a significant impact on the understanding of the mechanisms of metastasis in early stage breast cancer and thus will facilitate the prevention and/or fight against metastatic breast cancer.

Keywords: oncology,anticancer therapy,laboratory animal science