Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel mechanisms of adaptive and innate bacteriophage immunity (DEFEND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Microbes are engaged in an evolutionary arms-race with their viruses and have evolved a spectrum of adaptive and innate defense systems to limit viral predation. Mechanistic insights into defense systems have yielded truly revolutionary genetic tools ranging from CRISPR-based genome editing nucleases to restriction enzymes used for molecular cloning. Despite the ongoing effort to understand defense systems, many antiviral defense systems remain virtually unstudied in and outside their native microbial context, creating huge potential for scientific breakthroughs and development of further game changing applications. In the timely research proposed here I aim to uncover how adaptive (CRISPR) and innate immune systems protect bacteria from bacterial viruses (phages) at the molecular, cellular and population level. Based on our exiting unpublished observation that extremely phage resistant pathogens in our bacterial strain collection are true collectors of defense systems, I propose to investigate the contribution of each defense system and cooperativity between defense systems for broad and specific bacteriophage resistance. I furthermore aim to determine the molecular mechanism of a dominant set of related innate immune systems found in clinical pathogens, and to reveal how individual phages achieve immune evasion. To accomplish my goals, I plan to use an interdisciplinary approach combining state-of-the-art molecular microbiology and biophysics at the single molecule and single cell level, with bioinformatics and high-throughput synthetic genomics screens. The project may lead to fundamentally new insights into the mechanism and evolution of virus immunity and will further explore the genetic treasure trove at the interface of virus and host interactions. Our findings will have implications for controlling virus resistance, and will be vital to develop effective therapeutic strategies to treat antibiotic resistant pathogens based on bacteriophages.
Activities Releated to Science (ARTofscience)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Türkiye
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-06-01
End date: 2015-10-31
Duration (months): 17.0
Total project cost (EUR): 105673.75
EU funding (EUR): 76000.0
Participants: 1
Project status: CLOSED

The overall concept of our proposal is “Art of science” for both years respectively taking place on Friday 26 Septemper 2014 and Friday 25 September 2015 where we intend to generate an awareness and interest towards science by bringing scientists and all sections of the public close to each together in Istanbul, Turkey. Here, with this concept, we would like to enhance public recognition of researchers and their work, encourage active participation into scientific planning, experimentation and outcomes in one approache. Our approach is to assist the participants to be acquainted with how they “live, love, fun and learn” science in their daily life. For example, we will present them opportunities to the see how science affects our life, to experience the science in daily life by hands-on and minds-on activities, and to shape their view of science as a way of knowing. The participants will also have the opportunity to be introduced to the latest scientific developments in various fields by meeting and discussing with scientists. Vice versa, the researchers will find chance to make their work publically known. Furthermore, students at all levels will make meaning of their science courses, feel themselves closer to science and scientists, and eventually become more confident about science. Additional idea of the researchers’ night is to recognize the participants to be aware of the role of European Union framework programmes, the impact and effect they have had on the well-being of the public. This idea will be introduced by several activities involving participants and facilities demonstrated to the participants in EU corner.

Keywords: live,learn,science,research,night
Prospecting Secondary raw materials in the Urban mine and Mining waste (ProSUM)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Coordination and support actions
Countries involved: Estonia,Ireland,Italy,Germany,Ukraine,Austria,Spain,Cyprus,Belgium,Belgium,Romania,Romania,Switzerland,Sweden,Greece,Greece,Slovenia,Norway,Croatia,Poland,Sweden,France,France,France,Czechia,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,Japan,Denmark,Portugal,United Kingdom
Call: Secondary raw materials inventory (H2020-WASTE-2014-one-stage, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3704327.57
EU funding (EUR): 3051577.57
Participants: 45
Project status: CLOSED

The ProSUM project will establish a European network of expertise on secondary sources of critical raw materials (CRMs), vital to today’s high-tech society. ProSUM directly supports the European Innovation Partnership (EIP) on Raw Materials and its Strategic Implementation Plan calling for the creation of a European raw materials knowledge base. Data on primary and secondary raw materials are available in Europe, but scattered amongst a variety of institutions including government agencies, universities, NGOs and industry. By establishing a EU Information Network (EUIN), the project will coordinate efforts to collect secondary CRM data and collate maps of stocks and flows for materials and products of the “urban mine”. The scope is the particularly relevant sources for secondary CRMs: Electrical and electronic equipment, vehicles, batteries and mining tailings. The project will construct a comprehensive inventory identifying, quantifying and mapping CRM stocks and flows at national and regional levels across Europe. Via a user-friendly, open-access Urban Mine Knowledge Data Platform (EU-UMKDP), it will communicate the results online and combine them with primary raw materials data from the on-going Minerals4EU project. To maintain and expand the EU-UMKDP in the future, it will provide update protocols, standards and recommendations for additional statistics and improved reporting on CRM’s in waste flows required. ProSUM – “prosum” is Latin for “I am useful” – provides a factual basis for policy makers to design appropriate legislation, academia to define research priorities and to identify innovation opportunities in recovering CRMs for the recycling industry. The EUIN enables interdisciplinary collaboration, improves dissemination of knowledge and supports policy dialogues. A consortium of 17 partners, representing research institutes, geological surveys and industry, with excellence in all above domains will deliver this ambitious project.

Keywords: urban mine,weee,mapping,secondary raw materials,critical raw materials,data base,knowledge base
Birational and non-archimedean geometries (BirNonArchGeom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1365600.0
EU funding (EUR): 1365600.0
Participants: 1
Project status: SIGNED

Resolution of singularities is one of classical, central and difficult areas of algebraic geometry, with a centennial history of intensive research and contributions of such great names as Zariski, Hironaka and Abhyankar. Nowadays, desingularization of schemes of characteristic zero is very well understood, while semistable reduction of morphisms and desingularization in positive characteristic are still waiting for major breakthroughs. In addition to the classical techniques with their triumph in characteristic zero, modern resolution of singularities includes de Jong's method of alterations, toroidal methods, formal analytic and non-archimedean methods, etc. The aim of the proposed research is to study nearly all directions in resolution of singularities and semistable reduction, as well as the wild ramification phenomena, which are probably the main obstacle to transfer methods from characteristic zero to positive characteristic. The methods of algebraic and non-archimedean geometries are intertwined in the proposal, though algebraic geometry is somewhat dominating, especially due to the new stack-theoretic techniques. It seems very probable that increasing the symbiosis between birational and non-archimedean geometries will be one of by-products of this research.

Keywords: resolution of singularities,semistable reduction,wild ramification,berkovich analytic spaces
European Research Infrastructures in the International Landscape (RISCAPE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Italy,Italy,Finland,Norway,Finland,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 1999867.5
EU funding (EUR): 1999867.5
Participants: 16
Project status: CLOSED

RISCAPE will provide systematic, focused, high quality, comprehensive, consistent and peer-reviewed international landscape analysis report on the position and complementarities of the major European research infrastructures in the international research infrastructure landscape. To achieve this, RISCAPE will establish a close links with a stakeholder panel representing the main user groups of the report, including representatives from ESFRI, the OECD and Member state funding agencies to ensure usability and the focus of the Report. It will also benefit from close co-operation with other projects and initiatives in the European research infrastructures development to ensure consistency with the existing landscape work. Particularly, RISCAPE builds on the European Research Infrastructures (RIs) in the ESFRI landscape report (2016) and on the landscape analysis done or currently underway in the H2020 cluster projects. RISCAPE leverages the experts on the European RIs with extensive knowledge on the disciplines involved and RI development in Europe and the project benefits from the contacts and tools developed in the cluster- and international RI collaboration projects to maximize the discipline-specific usability of the results. A key factor in the RISCAPE analysis is that the complementarities will be analyzed in a way which is natural and suitable for the discipline and RI in question. The resulting Report and the used methods will be independently peer reviewed to maximize the usability and objectivity of the information provided for the EU strategic RI development and policy. The project answers directly to the European Commission strategy on EU international cooperation in research and innovation, particularly on the need to obtain objective information in order to help implement the (EC) strategic approach.

Keywords: research infrastructures,landscape analysis,esfri,oecd,international initiatives,global observing systems,research diplomacy
Genomic and proteomic analysis of Palaeolithic, Neolithic and Bronze Age humans from Central-Southern Italy (PALAEO-ENEO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2019-10-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

This project aims at reconstructing the ancestry and oral disease of Palaeolithic, Neolithic and Bronze Age anatomically modern humans from Central-Southern Italy, using genome-wide profiling and mass spectrometry-based proteomic analysis of skeletal remains and mineralised dental plaque (archaeological dental calculus). In Europe, the transition from hunter-gatherer to agricultural communities (Neolithisation) and the Bronze Age migration into Central Europe from the Asian steppe were the most important demographic events since the initial peopling by anatomically modern humans. However, until now, no Palaeolithic and only a few of Neolithic and Bronze age individuals from South Europe have been characterised for genomic analysis. As a consequence, the genetic base of outstanding peopling and migratory processes in prehistoric Europe, such as: (a) the East-West population structure among European hunter-gatherers, and (b) the Neolithic Southern European horizon known as the Cardial culture, still need to be fully understood. Similarly, metagenomic analysis of Palaeolithic and Neolithic dental calculus has been limited to preliminary screening of a limited number of samples, with no associated metaproteomic analysis. What taxonomic groups and metabolic functions were lost or gained with Neolithisation? How this affected oral heath? The genomic characterisation of Palaeolithic, Neolithic and Bronze Age humans from Southern Europe will be integrated with a metagenomic and metaproteomic analysis of dental calculus to produce the richest possible personal “-omics” profiling so far achievable for ancient humans. The two main research objectives are: 1. Integrate Palaeolithic, Neolithic and Bronze Age human genomic data from Central-Southern Italy within the genomic landscape available for all ancient and present-day West Eurasians, and 2. Reconstruct the oral microbiome, and its metabolic interactions with the host, before and after Neolithisation.

Keywords: ancient dna,ancient proteins,migration in prehistoric europe,oral microbiome,mass spectrometry
Pairing Business with Scientific Expertise (QUESTPAIR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Universities in Europe are generating an estimated €18 billion in revenues from contract research, consultancy, and use of facilities and equipment. This is expected to grow as urgent global challenges such as climate change create huge demand for new technologies, data, and materials. Also the EU and national governments are increasingly promoting academic-business collaborations to boost the knowledge economy. However, a remaining problem is that many businesses still have difficulty finding scientific experts, equipment, data, and materials across the globe. Whereas some online platforms exist to match business needs to freelance scientists, there is a lack of services to find expertise and assets for collaborations within universities and organisations, leaving a huge market largely untapped. Therefore, we are developing QuestPair, an online platform where businesses can post their scientific and technological needs, to which scientific experts can propose projects and suggest equipment, data and materials. Universities on QuestPair can directly participate in the negotiation of pricing and contracts. We believe that QuestPair could potentially facilitate around 6000 years of project work within the next 6 years, while reaching yearly revenues of ~€40 million. The QuestPair team combines research and data analysis skills with expertise in business, consultancy and software development. We are already developing a minimum viable product (MVP) and are receiving positive feedback from the scientific and business communities. This feasibility study aims to create a detailed picture of mediation/brokerage services that companies, scientific experts and universities need. We take an iterative approach, where we conduct questionnaires and market research, implement the results in the MVP, measure user response, and develop further. We explore different marketing strategies and evaluate several financial models to create a solid and detailed business plan.

Keywords: platform,science,technology,business,universities,projects,materials,knowledge economy,expertise,equipment,consultancy,freelance,marketplace,blockchain,machine learning
High-Fidelity Photonic Quantum Gates (HIFIG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

An efficient nonlinear quantum gate between two single-photons is highly desirable, as it will enable processing quantum information stored in optical photons. This capability is essential for building next generation of quantum networks, and optical quantum computing. However, such a device is constrained by lack of interaction between optical photons in natural environments. Interestingly, cavity quantum electrodynamics provides several paths towards achieving nonlinear interaction between photons. This action aims at realizing a high fidelity and efficient nonlinear gate between two single-photons using a compact solid-state design. Our approach is based on using the spin-state of a hole in an InAs/GaAs quantum dot to mediate the interaction between the photons. It has recently been demonstrated that the quantum coherence of the hole state can be on the order of several hundreds of nanoseconds. Also, the hole-states have been shown to have very coherent optical transitions which makes them an ideal candidate to realize spin-photon interfaces. In order to boost the interaction between the photons and the quantum dot, a novel microcavity structure will be used. The microcavity structure has recently been developed in the host group and shows spectacular features such as a Q-factor of 1 million, and a cooperativity of 100, making the combination of the hole-state and the microcavity structure an ideal platform to realize photonic gates. The results of this action will be highly instrumental for building quantum repeaters, and may open new directions for quantum computers based on optical photons. For instance, such a nonlinear gate may be combined with a linear network of coupled waveguides to enhance the simulation capabilities of the linear network. Finally, this action is aligned very well with the goals of the Quantum Technologies flagship initiative, and will contribute to the collective effort by the European researchers towards a lead in quantum technologies.

Keywords: quantum dots,spin physics,quantum gates,photon photon gates,spin photon interaction,cavity qed
Implantable flexible electro-active sensing platform for smart intraocular applications (GRAVITEYE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-03-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: SIGNED

The equilibrium state of the eye is achieved through a delicate balance of fluid flow, with a continuous cycle of production and drainage. The intraocular dynamics maintains the intraocular pressure (IOP) at a constant level but any condition that adversely affects its stability results in the onset of glaucoma, the leading cause of irreversible blindness. The underlying mechanisms are by no means fully understood but several glaucoma theories rely on the fluid flow-related phenomena. High IOP is the major risk factor and most treatments include IOP-lowering actions. However, gold-standard IOP measurement is just a snapshot with low sensitivity. Thus, many questions remain open that are critical to understand the dynamic factors that control the IOP. The GRAVITEYE project will develop a smart intraocular implant based on novel biomedical sensing technologies to monitor the IOP dynamics, track the pulsatile fluctuations and decipher the intraocular fluid motion. The integrated platform will be encapsulated in a commercial intraocular lens and include (i) bio-fitted flexible sensors, (ii) ultrathin-film stretchable interconnections and (iii) a Radio-Frequency antenna for wireless powering and communication. The completion of the smart platform and its further validation will unveil novel scientific avenues in glaucoma and open up new possibilities to explore potential biomarkers for the microgravity-induced ocular changes in astronauts, one of the highest-priority physiological area in space medicine. GRAVITEYE, is built on the complementary expertise of the host in stretchable electronics and ultrathin chip integration for biomedical applications and of the fellow in Visual Optics, Photonics and Optical Engineering, and will provide a comprehensive training plan, to boost Dr. Pérez-Merino career. The outcome of this project will in addition enhance the EU leading position in flexible electro-optic components for smart medical implantable devices and vision care.

Keywords: smart ophthalmic devices,stretchable electronics,ultra thin si chips,implantable electro optic devices,hybrid packaging,glaucoma,intraocular pressure sensor,smart intraocular lens