Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Disruptive Digitalization for Decarbonization (2D4D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy,Italy
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1498375.0
EU funding (EUR): 717005.0
Participants: 2
Project status: SIGNED

By 2040, all major sectors of the European economy will be deeply digitalized. By then, the EU aims at reducing greenhouse gas emissions by 60% with respect to 1990 levels. Digitalization will affect decarbonization efforts because of its impacts on energy demand, employment, competitiveness, trade patterns and its distributional, behavioural and ethical implications. Yet, the policy debates around these two transformations are largely disjoint. The aim of the 2D4D project is ensure that the digital revolution acts as an enabler – and not as a barrier – for decarbonization. The project quantifies the decarbonization implications of three disruptive digitalization technologies in hard-to-decarbonize sectors: (1) Additive Manufacturing in industry, (2) Mobility-as-a-Service in transportation, and (3) Artificial Intelligence in buildings. The first objective of 2D4D is to generate a one-of-a-kind data collection to investigate the technical and socio-economic dynamics of these technologies, and how they may affect decarbonization narratives and scenarios. This will be achieved through several data collection methods, including desk research, surveys and expert elicitations. The second objective of 2D4D is to include digitalization dynamics in decarbonization narratives and pathways. On the one hand, this entails enhancing decarbonization narratives (specifically, the Shared Socio-economic Pathways) to describe digitalization dynamics. On the other hand, it requires improving the representation of sector-specific digitalization dynamics in Integrated Assessment Models, one of the main tools available to generate decarbonization pathways. The third objective of 2D4D is to identify no-regret, robust policy portfolios. These will be designed to ensure that digitalization unfolds in an inclusive, climate-beneficial way, and that decarbonization policies capitalize on digital technologies to support the energy transition.

Keywords: digitalization,decarbonization,additive manufacturing,mobility as a service,artificial intelligence
Cognitive Automation Platform for European PRocess Industry digital transformation (CAPRI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Italy,Spain,Spain,Italy,Austria,Germany,Spain,Spain,Spain,Poland,Greece,Serbia
Call: Digital technologies for improved performance in cognitive production plants (IA) (H2020-NMBP-SPIRE-2019, 2019)
Start date: 2020-04-01
End date: 2023-09-30
Duration (months): 42.0
Total project cost (EUR): 6990666.08
EU funding (EUR): 6104451.75
Participants: 15
Project status: SIGNED

European process industries need to address resources, materials and environmental constrains by improving its flexibility and performance through cognition capabilities, as existing in human intelligence. Digitisation is the main enabler for such capabilities. CAPRI will develop, test and experiment an innovative Cognitive Automation Platform (CAP) for Process Industry Digital Transformation, enabled by cognitive tools that provide existing process industries flexibility of operation, improvement of performance across different indicators (KPIs) and state of the art quality control of its products and intermediate flows. The CAP encompasses methods and tools for governing six Digital Transformation pathways (6P, Product, Process, Platform, Performance, People, Partnership), a Reference Architecture with four levels of cognitive human-machine interaction (industrial IoT connections, smart events processing, knowledge data models and AI-based decision support), a set of reference implementations, both commercial and open source, for batch, continuous and hybrid process industry plants, and a toolbox of cognitive solutions for planning, operation, control and sensing. The CAP will be modular and scalable, so that advanced applications could be developed and integrated on top of it and its validation will take place addressing manufacturing challenges in industrial operational environments of three outstanding process sectors: asphalt (minerals), steelmaking, and pharma industry (chemical). CAPRI results could be applied to a wide range of problems and challenges in future cognitive plants. CAP Platform and the cognitive tools included in it can be replicable in areas of production planning, control, automated processes and operations of virtually all SPIRE sectors. A strong and experienced consortium of 7 EU companies and 6 RTOs will ensure maximum exploitation and replication of the systems developed.

Keywords: artificial intelligence,digital transformation,automation architectures,asphalt,steel,pharmaceutical
The evolution of land plant functional traits and how they terraformed Earth (TERRAFORM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Ireland
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2498066.25
EU funding (EUR): 2498066.0
Participants: 1
Project status: SIGNED

TERRAFORM will mark a step-change in the investigation of biosphere impacts on the Earth system. It will integrate concepts and rich data sources from contemporary global trait ecology with novel simulated paleo-Earth weathering/decomposition experiments and high-resolution analyses of fossil plant paleotrait data to quantify the terrestrial biosphere’s impact on the carbon, nutrient and hydrological cycles in deep-time. The focus on extensive fossil plant archives spanning three episodes of major environmental and biotic change [Pennsylvanian-Permian glacial interglacial cycles; the Triassic-Jurassic mass extinction; Cretaceous OAEs] will yield insights on plant responses to and effect on other components of the Earth system. TERRAFORM will develop new paleo-trait proxies for fossil plants. TERRAFORM will improve the parameterization and performance of weathering and terrestrial ecosystem models. Ultimately, TERRAFORM will contribute to the discovery of how plants TERRAFORMed the Earth, how plant functional traits evolved over the past 300 million years and it will establish a new methodological framework to extract the full untapped potential data resources from fossil plants. TERRAFORM will increase literacy in Earth System Science among a non-traditional audience through an embedded artist-in-residence programme.

Keywords: palaeobotany,palaeontology,trait ecology
Muli-path optical fibre modules (ModeCore)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The business concept is to provide advanced optical fibre components, modules and sub-systems utilising advanced, new fibres; few mode fibre (FMF), multi-core fibre (MCF). Sensing systems based on these new fibres and space division multiplexing (SDM) systems, for enhancing future network capacity, are being developed, but the problem is that there are no commercially available component products to build these systems. The project objective is to develop a range of optical fibre component, module and sub-system products for FMF and MCF solutions in network and sensing applications. Basic building block components and fully integrated multiplexers and amplifiers for high channel count systems will be developed. Demand for components utilising these new fibres is continuing to increase and technical specifications are developing. Within this project Phoenix will have the resource to work with the customer, to develop a required specification of product and supply to the customers’ needs. The feasibility assessment will enable a full commercial assessment to be made. Current technology status, competitive landscape, operator forecast and customer requirements will be assessed. Potential partners and sub-contractors to develop the suite of products will be identified and a roadmap with route to market will be defined. The market is global and this project will provide the opportunity for a European SME to be at the forefront of this key future technology.

Keywords: photonic components,optical fibre,space division multiplexing,optical fibre sensing,communication networks
HARDWARE ENABLED CRYPTO AND RANDOMNESS (HECTOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Austria,Belgium,Slovakia,France,France,France,Netherlands
Call: Cybersecurity, Trustworthy ICT (H2020-ICT-2014-1, 2014)
Start date: 2015-03-01
End date: 2018-07-31
Duration (months): 41.0
Total project cost (EUR): 4494087.5
EU funding (EUR): 4494087.5
Participants: 9
Project status: CLOSED

A single flipped bit or a weak random number generator can cause secure systems to fail. The main objective of this proposal is to close the gap between the mathematical heaven of cryptographic algorithms and their efficient, secure and robust hardware implementations. It requires integrating secure cryptographic primitives such as random number generators (RNGs) and physically uncloneable functions (PUFs), together with physical attack countermeasures. Therefore we will study, design and implement RNGs and PUFs with demonstrable entropy guarantees and quality metrics. This includes on-the-fly entropy testing and physical attacks evaluations. This will enable more secure systems and easier certification. State-of-the-art cryptography and countermeasures can fail due to low-entropy random numbers. The unknown is ‘how much’ they will fail and how much entropy degradation can be tolerated (due to attacks or RNG designs mixing true and pseudo randomness). Our objective is to study the strength and gradual security degradation when using lower entropy random numbers. This will enable more optimal and secure implementations. These objectives have to be combined with hardware efficiency and flexibility. This means addressing the extremely low-cost and low-power requirements of constrained embedded devices, low-latency of real-time memory encryption, or high throughput of future terabit networks. Ultimately, we target security building blocks that are flexible, hardware-friendly, efficient, and robust against physical attacks, and which will be demonstrated on European relevant use cases. We bring together experts from industry, academia and evaluation labs with collective ambitions, potential and track records and with complementary expertise, dissemination and impact potential. Results will not only benefit the companies involved and their customers, but also the broader ICT through publications and inputs to standardization and certification bodies.

Keywords: entropy testing,physical attacks and countermeasures,certification,standards
The Power of Maternal Microbes on Infant Health (MAMI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2020-12-31
Duration (months): 67.0
Total project cost (EUR): 1499979.0
EU funding (EUR): 1499979.0
Participants: 1
Project status: CLOSED

Recent reports suggest that early microbial colonization has an important role for in promoting health. This may contribute to reduce the risk of chronic diseases such as obesity, allergies and inflammatory conditions. Advances in understanding host-microbe interactions imply that maternal microbiota plays a crucial role on health programming. This process begins in utero and it is modulated by mode of delivery and diet. My research has shown that i) specific shifts in milk microbial composition are associated with lactation time and mode of delivery, ii) milk microbes drive the infant microbiota composition; iii) maternal microbiota dysbiosis may be transferred to the infant. However, factors defining maternal microbiota and its biological role upon infant’s health are not yet fully understood. Hence, this project aims to characterize maternal microbes to be transferred to neonates and determine their function in infant health programming. The specific aims are:(1) understanding how the maternal microbiome is influenced by host and environmental factors;(2) characterizing the microbial core and bioactive compounds transmitted to the offspring mainly via breastfeeding and their key roles in the microbial modulation and host response;(3) understanding the interactions among breast milk bioactive compounds and their role in infant health;(4) shedding light on how maternal microbes influence the infant immune system & (5)development of new dietary strategies and therapies based on microbial replacement and modulation. To achieve these objectives, a systems biology approach by means of state-of-the-art techniques and new methodologies based on subpopulation enrichment by flow cytometer-sorter to study host–microbe interactions will be used. Results obtained will demonstrate the interaction between infant nutrition, microbes and host response in early life and its key role in health programming, enabling new applications in the field of personalized nutrition & medicine.
A Unified Route to Polycyclic Terpenes (Route2polyTepr)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

In this proposal we would like to demonstrate the strategic role that xanthates could play in providing a unified approach to a multitude of polycyclic terpenes and in shortening considerably the synthetic routes. By enabling the strategic intermolecular creation of new carbon-carbon bonds on unactivated alkenes and the formation of rings not readily accessible by other methods, the degenerative radical exchange of xanthates opens numerous synthetic avenues not hitherto available. Unusual retrosynthetic disconnections will now be envisaged, and it is hoped that a unified, short, and practical route to numerous classes of polycyclic terpenes and terpene alkaloids can be implemented. Demonstration of the advantage of using xanthate transfer to the synthesis of polycyclic terpenes will bring the academic’s attention to novel applications of radical reactions, promoting the development in the area.

Keywords: total synthesis,terpenes,radical chemistry,xanthate transfer
Early Upper Palaeolithic mobility and technological decision-making under changing environmental constraints: case studies from Belgium and Romania (PALMOBI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The PALMOBI project investigates Early Upper Palaeolithic (EUP) hunter-gatherer interactions with their environment at micro- and macro-regional scales under variable ecological conditions through the integrative use of cutting-edge interdisciplinary methodologies and their application to the archaeological record of the Aurignacian and the Gravettian across two contrasting regions (temperate Belgium & continental Romania). A comparison of these two regions by applying state-of-the-art stone tool technology and raw material economy analyses, geochemical sourcing and GIS geospatial techniques in tandem with anthropological methods and theories derived from the human behavioural ecology and social agency has never previously been attempted. While continental European Palaeolithic research is mainly concerned with origins, technological lineages, and culture history, the project, by drawing on the training provided in Cambridge, will contribute to developing an innovative framework to assess EUP hunter-gatherer mobility strategies and technological decision-making, hence adaptability, in the face of variable palaeoenvironmental constraints. Besides helping understand the mechanisms underlying variability in Aurignacian and Gravettian techno-economic systems, the methodological advances resulting from this project concern the resilience of technological behaviour in the face of climate change and the role of mobility in promoting social change, and will be applicable to any period and context in the prehistory of Europe and further afield.

Keywords: early upper palaeolithic,mobility,lithic technology,raw material economy,environmental change
Oil, fat and contaminant free moulding through advanced low friction and fretting-resistant coating solution (cleanMOULD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Denmark
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Fretting corrosion is the limiting factor in the life of many plastic injection moulds. Micrometer-deep vents are designed and ground in the mould surfaces to allow air to escape from the mould as the plastic fills the mould cavities. Each time that the mould is closed, the contacting surfaces “adjust” or slip to accommodate machinery errors of form, and this rubbing combined with impact of the vibrations of the moulding machine produces fretting corrosion or wear. The shape and dimensions of the mould are seriously affected also causing the vents to disappear and regrinding is necessary. Eventually, the mould dimension ends up out of specification, and the mould must be scrapped. The burden of fretting corrosion is transversal to all industries relying on injection moulding. CemeCon Scandinavia (CSA) has extensive experience on solving tribological problems in injection mould’s operational environments. Our DLC (Diamond Like Carbon) coating technology is currently in use for dry lubrication of critical sliding/ moving mould parts, allowing for an oil/grease free operation. However, resistance towards fretting wear needs to be significantly improved, which creates the main driver for the current innovation project. With cleanMOULD, we will introduce a novel coating solution to protect critical mould elements from fretting wear, while simultaneously allowing oil-free operation, thus minimizing the risk of contamination in sensitive industries like medical plastics and food packaging. cleanMOULD will significantly contribute towards profitability of its targeted end-users, by increasing mould’s service life up to 10x, while also enabling lower maintenance costs. Successful market introduction of cleanMOULD will equally create substantial value to CSA, with estimated yearly direct revenue around €10 million, 5 years post-project, to which can be summed up to €5 million yearly revenues from licensing.

Keywords: fretting wear,dlc coatings,tribology,injection moulding,dry lubrication
Fate of mammary stem cells during tumorigenesis and clinical implications (MSCFate)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

One of the most challenging questions in breast cancer biology is to elucidate the origin of tumor heterogeneity and its contribution to therapy failure. Accumulating evidence suggests that the cell-of-origin, the cell that acquires the first oncogenic event, may define the molecular portrait of the resulting tumor. The fate of mammary Stem Cells (MSC) upon oncogenic perturbation has been poorly explored. Moreover, the Phosphoinositide 3-kinase (PI3K) pathway regulates proliferation/differentiation of MSC and is found hyperactive in breast cancer cells, for example through mutations in PIK3CA, the gene coding for its catalytic subunit. I hypothesize that expression of PIK3CA mutations will perturb mammary tissue homeostasis, initiate mammary cancer and trigger formation of stem-like cancer cells. Using state-of-the-art in situ genetic lineage tracing, I will determine the fate of MSC (identified recently as Procr+ cells) after conditional expression of PIK3CA hotspot mutations (H1047R, E545K). I will also characterize early molecular events responsible for promotion of transformation (Aim 1). When tumors develop, I will determine tumor phenotype and eventual progression to metastasis (Aim 2). Consequently, this study will generate a new mouse model of breast cancer that will be useful for preclinical studies. A panel of PI3K inhibitors is currently under Clinical investigation and clinical reports have shown that the combination of standard chemotherapy with PI3K inhibitors reduces tumor growth but drug-resistance often occurs. To identify resistance mechanisms to PI3K inhibitors, I will generate in vivo models of drug-resistance (Aim 3). My studies will use both hypothesis driven and unbiased approaches, they should: 1. better elucidate transformation of MSC and the resulting tumor heterogeneity, 2. pinpoint novel targets/biomarkers. Ultimately this knew knowledge should result in better therapies for patients.

Keywords: breast cancer,cell of origin,tumor heterogeneity,lineage tracing,mice models,transformation,mammary stem cells,procr,cancer stem cells,pi3k,pi3k inhibitors,therapy resistance