Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Energy-Hub for residential and commercial districts and transport (E-HUB)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Italy,Spain,Belgium,Germany,Finland,France,Poland,Belgium,Belgium,Italy,United Kingdom,Germany
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-12-01
End date: 2014-11-30
Duration (months): 48.0
Total project cost (EUR): 11585516.09
EU funding (EUR): 7993709.55
Participants: 19
Project status: CLOSED

The ambition of this project is to enable the utilisation of the full potential of renewable energy (up to covering 100% of the energy demand on district level). In order to reach this goal, the E-hub concept is developed, which is crucial for the implementation of such a large share of renewables. An E-Hub is a physical cross point, similar to an energy station, in which energy and information streams are interconnected, and where the different forms of energy can be converted into each other and/or can be stored. The E-hub exchanges energy via the energy grids between the different actors (e.g. households, renewable energy plants, offices), who may be a consumer at one time, and a supplier at another time. The consumers and suppliers exchange information on their energy needs and energy production with the energy hub, the hub then distributes the energy available in the most efficient way. For proper matching of supply and demand, the E-hub uses conversion and storage of energy, as well as load shifting. The consumers and suppliers should be connected to this E-hub by means of bi-directional energy grids (low and/or high temperature heat grid, cold grid for cooling, electrical grid (AC and/or DC), gas grid (H2, biogas, syngas). The renewable energy may be generated locally (e.g. from PV on residences) or by centralised means (a geothermal plant or a large CHP located within the district that may be fuelled by biofuel or H2). The E-Hub concept holds for all types of energy flow, from heating and cooling to electricity, biogas and H2, and may connect not only households but also (electrical) cars, commercial buildings or industry. The aim of the proposed project is: to develop the e-hub as a system, to develop technologies that are necessary to realize the system, to develop business models in order to overcome institutional and financial barriers, and to demonstrate an E-hub in the form of a real situation and in a few case studies/feasibility studies.

Keywords: e-hub,bi-directional energy grid,energy exchange,energy distribution,renewable energy,consumers,suppliers,business models,demonstration
Customer-oriented and eco-friendly networks for healthy fashionable goods (CORENET)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: New production
Action type: Collaborative project
Countries involved: Italy,Portugal,Germany,France,Italy,Italy,Belgium,Germany,Switzerland,Germany
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-06-01
End date: 2013-05-31
Duration (months): 36.0
Total project cost (EUR): 5133189.0
EU funding (EUR): 3502499.0
Participants: 14
Project status: CLOSED

The objective of CoReNet is to address consumer needs and expectations of wide range of European citizens as well as specific target groups - such as elderly, obese, disabled, or diabetic persons -by supplying small series of functional and fashionable clothes and footwear of high quality, affordable price and eco-compatibility. Therefore the European Textile, Clothing and Footwear Industry will be able to provide customised health fashionable goods for relevant social niches, so improving its market shares. In order to design, develop, produce and distribute the related small order quantities in a cost- and eco-efficient way a new framework and components for new collaborative networking will be developed, enabling to stay as long as digital and to produce on-demand. This includes: a) consumer integrated collaborative eco-oriented design, and configuration of ”healthy”; wearables using web-enabled virtualisation and ”green”; materials, b) a radical renewal of critical value creation steps by the adoption of Rapid Manufacturing technologies for optimised digital printing and laser engraving; and c) the overall integration and co-ordination of business processes and information exchange by a set of new (web)services for network design and ad-hoc (re-)configuration, for real-time planning, forecasting and replenishment, and for tracking and tracing of ecology and quality. Within COReNet framework, all partners of the value creating sectors will become able to co-ordinate value creation processes, with the end consumer as driving actor. CoReNet will be collaboratively tested and demonstrated within industrial plants, thus showing the full potential of the new sustainable collaborative cross-sector networking approach

Keywords: supply networks small series health footwear and clothing
Advanced Intelligent Machine Adaptive Control System (AIMACS)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: New production
Action type: Collaborative project
Countries involved: Italy,Germany,Finland,Spain,Belgium,Germany,Israel,Hungary
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-08-01
End date: 2013-07-31
Duration (months): 36.0
Total project cost (EUR): 4482574.0
EU funding (EUR): 2959897.0
Participants: 10
Project status: CLOSED

Current machining technologies and practices have many inefficiencies. Numerous unpredictable machining variables often cause overload and unstable conditions and catastrophic damage to the machine tool system. In addition, this results in frequent disruptions in production that can often be excessive, leading to considerable losses in productivity, capital and energy resources. In an effort to prevent these occurrences, process planners, programmers and operators are forced to adopt a conservative approach and they program for the “worst case” scenarios - resulting in considerable inefficiency in machine tool utilization. The objective of the project is to develop active, self-optimizing “intelligent” adaptive control systems which will continuously analyse a wide range of monitored parameters of the machining process and automatically adapt the machine operation in real-time to its optimal performance in order to account for continuously varying machining conditions, production disruptions and anomalies, plant performance variations and random changes in production plans. AIMACS will develop reliable techniques for monitoring the most critical machining parameters such as cutting load, vibrations and energy consumption. Based on this information and taking into account the costs for tools machining time, maintenance time, energy, etc. AIMACS will optimise in real time the overall production process based on productivity/cost criteria in order to ensure effective adaptive and sustainable machining As a plug-and-produce system, AIMACS will be applicable to newly built machines and also for retrofit to the installed base of existing machines in the European manufacturing industry. Since the installed base of machines in Europe is estimated to be more than 1,000,000 machines, the impact of AIMACS on the efficiency, productivity and competitiveness of the European domestic manufacturing industry should be very substantial.

Keywords: adaptive control,self-controlled systems,energy efficiency
The role of Tumour suppressor of lung cancer 1 (TSLC1) signalling in lung repair and cancer-associated epithelial-mesenchymal transitions (EMTs) (TALC-EMT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: United Kingdom
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2010-10-01
End date: 2015-09-30
Duration (months): 60.0
Total project cost (EUR): 1489715.0
EU funding (EUR): 1489715.0
Participants: 1
Project status: CLOSED

Chronic lung diseases including COPD and cancer account for more than 10% of deaths in European countries and lung cancer remains the most common and most lethal cancer type worldwide. Lung cancer mortality rates have also remained constant for over 40 years, largely due to late stage diagnosis and frequent metastases. Despite these trends the signalling pathways regulating lung cancers remain largely unexplored. Although loss of Tumour Suppressor of Lung Cancer 1 (TSLC1) is implicated in lung cancer metastases its normal lung functions remain entirely unknown. Recently, I determined that the TSLC1 signalling pathway regulates cell proliferation, motility, skin repair, and cancer severity by inhibiting stem cell EMTs. This proposal will determine how TSLC1 regulates lung EMTs to influence repair and disease outcomes. I will correlate TSLC1 expression with EMTs in repairing and diseased lungs, investigate how lung TSLC1 signalling influences repair and disease outcomes using transgenic and knockout mice, and identify mechanisms through which TSLC1 modulates lung phenotypes using in vitro overexpression and knockdown studies. This research will elucidate TSLC1 signalling pathway functions in lungs and should suggest new therapeutic opportunities for human lung disease.

Keywords: airway,repair,oncogenesis,metastasis
Molecular mechanisms underlying control of renal epithelial proliferative homeostasis (KIDNEY CANCER)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Switzerland
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2010-12-01
End date: 2015-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

This research grant has two major aspects. The first seeks to understand the molecular and cellular basis of the evolution of clear cell renal cell carcinoma(ccRCC), the most frequent form of kidney cancer. We will utilise an integrated approach based on mouse genetics, the use of primary kidney epithelial cell culture systems, genetic screening approaches using RNA interference libraries and analysis of the genetic and molecular changes that arise in human kidney tumours. The rationale behind these studies is that by better understanding the molecular causes of ccRCC it will be possible to identify new molecules or signaling pathways that could serve as appropriate therapeutic targets. The second aspect of this grant relates to the development of a flexible experimental platform that will allow the rapid and simultaneous up- and down-regulation of gene expression in the mouse kidney in a manner in which the affected cells are marked by a luminescent marker. This system will be based on the injection of modified lentiviral gene overexpression and gene knockdown vectors, allowing us to exploit recently-developed genome-wide cDNA libraries and RNA interference libraries. This experimental system should be equally applicable to other organ systems and will allow for the first time a systematic approach to the manipulation of gene expression in living mice, additionally bypassing the time limitations associated with conventional mouse genetic approaches. We aim to develop this system within the biological context of this grant and will combine it with live-animal imaging approaches to generate a series of mouse models of ccRCC. These will ultimately serve as invaluable tools for testing novel therapeutic approaches against this currently untreatable disease.

Keywords: mouse genetics,cancer model
European Risk from Geomagnetically Induced Currents (EURISGIC)

Framework: FP7 — Cooperation
Programme: Space
Destination: Strengthening the foundations of Space science and technology
Action type: Collaborative project
Countries involved: Finland,United Kingdom,Sweden,Hungary,Russian Federation,United States,Sweden
Call:  (FP7-SPACE-2010-1, 2010)
Start date: 2011-03-01
End date: 2014-02-28
Duration (months): 36.0
Total project cost (EUR): 1561175.4
EU funding (EUR): 1056184.0
Participants: 8
Project status: CLOSED

Geomagnetically induced currents (GIC), occurring during magnetic storms, pose a natural disaster risk to the reliable operation of electric power transmission grids, a European critical infrastructure as defined by the Council Directive 2008/114/EC. The EURISGIC project will produce the first European-wide real-time prototype forecast service of GIC in power systems, based on in-situ solar wind observations and comprehensive simulations of the Earth's magnetosphere. By utilising geomagnetic recordings, we will also derive the first map of the statistical risk of large GIC throughout Europe. Because the most intense geomagnetic storms constitute the most remarkable threat, with a risk of power grid blackouts and destruction of transformers, we will also investigate worst-case GIC scenarios based on historical data. EURISGIC will exploit the knowledge and advanced modelling methods developed in Europe and North America. Close communication throughout the project with a stakeholder advisory group will help in directing the research and outreach appropriately. The results of this study will help in the future design of more robust and secure protection against GIC in power transmission grids in Europe, which are anticipated to become increasingly interconnected and geographically wider. GIC are observed in power transmission grids, oil and gas pipelines, telecommunication cables and railways. This project focuses on high-voltage power transmission networks, which are probably currently the most susceptible to GIC effects. Geomagnetic storms cover large geographical regions, at times the whole globe. Consequently, power networks are rightly described as being European critical infrastructures whose disruption or destruction would have a significant impact on at least two member states (Council Directive 2008/114/EC; Article 2b; Annex I).

Keywords: space weather,geomagnetically induced currents,geomagnetic storms,power transmission networks
Siglecs as mediators of the pancreatic cellular crosstalk in diabetes (SIADIA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Germany
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 1363847.0
EU funding (EUR): 1363847.0
Participants: 1
Project status: CLOSED

The mechanisms of the immune and endocrine cell interaction within the islet and resulting β-cell death are highly complex and largely unknown. To investigate the cellular crosstalk in the pancreas and how its disturbance leads to insufficient insulin production is important to understand the pathology of the disease. This is the major goal of this project. Activation of inflammation is not only a trigger for β-cell destruction, but also a major factor for the metabolic syndrome, including insulin resistance and complications of diabetes. Signalling and activation of immune cells is facilitated by secreted pro-inflammatory stimulators and via cell-cell interactions. I propose that a group of adhesion and signalling molecules, the Siglecs (sialic acid–binding immunoglobulin (Ig)-like lectins) mediate such interactions. They are responsible for immune system activation and have been initially found in cells of hematopoietic origin. I made the groundbreaking observation of cell type specific Siglec expression in the human pancreas: Siglecs were differentially expressed in glucagon producing α-cells, and in insulin producing β-cells. A diabetic milieu had an inductive effect on Siglec expression in the α-cells, but lead to decreased β-cell specific Siglecs. This loss of Siglecs in the β-cell could be detrimental and result in an excessive cytokine release and in turn switches on Siglec responses in neighbouring cells. In my proposed studies I will investigate the role of Siglecs in the cellular network in islets and in the circulation to probe whether changes in Siglec expression are causative in the development of diabetes. My project is a pioneer and multidisciplinary study combining the current knowledge of glycobiochemistry and β-cell biology in diabetes. The project uses multi-model cell systems of healthy and diseased human pancreatic tissue, isolated human islets, isolated human β-cells as well as diabetic mouse models, all of them being absolutely novel and high-risk to a large extend.

Keywords: diabetes,beta-cell,inflammation,siglecs
Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices (ALLFUN)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Italy,France,France,United Kingdom,Netherlands,United Kingdom,Switzerland,Romania,Spain
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2010-12-01
End date: 2014-05-31
Duration (months): 42.0
Total project cost (EUR): 7310860.54
EU funding (EUR): 5524704.0
Participants: 14
Project status: CLOSED

The ALLFUN proposal aims at defining the cellular and molecular mechanisms by which ubiquitous airborne or commensal fungi contribute to immune homeostasis and its dysregulation leading to allergy and inflammatory diseases. Breakthroughs in understanding how mucosal homeostasis is established, maintained or disrupted in the presence of fungi should be sources of new therapeutic targets and drugs (i.e. anti-inflammatory, immunomodulatory and anti-infectious molecules). European scientists representing the leading edge of this field are brought together here in a unique synergistic and cross-cutting collaboration that addresses a major medical and economic problem of considerable importance to the health care sector. The study will be centered on yeasts and filamentous fungi known to be associated with a number of inflammatory, autoimmune and allergic diseases. Via a multidisciplinary systems biology study combining fungal genetics, clinical research and animal models in a systems biology approach, integrating traditional wet-lab methods with those of functional genomics, immunomics, allergomics and bioinformatics, the ALLFUN project meets the criteria of the call, the strategic objective of which is “to elucidate mechanisms by which infections may lead to aberrant activation of inflammation, the lack of resolution of which is responsible for inflammatory diseases”. The anticipated results are highly relevant to society in terms of reducing the burden of mortality and suffering in patients with fungus-related diseases, identifying more accurate biomarkers for immunological disorders, optimizing and possibly reducing the cost of antifungal therapy by association with anti-inflammatory strategies that targets pathogenicity rather than microbial growth, the host-pathogen interface rather than the pathogen. Understanding the spectrum of immunological responses to fungi is perhaps the single most important challenge in the field of medical mycology.

Keywords: fungal diseases,inflammation,allergies,autoimmunity,immunodiagnostics,intervention strategies,snps analysis
Prokaryotic RNomics: Unravelling the RNA-mediated regulatory layers (PROKRNA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: Israel
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2011-01-01
End date: 2016-06-30
Duration (months): 66.0
Total project cost (EUR): 1499540.0
EU funding (EUR): 1499540.0
Participants: 1
Project status: CLOSED

Pioneering studies from the recent year, including those published by the PI of this proposal, are revolutionizing our perception of prokaryotic transcriptomes, and reveal unexpected regulatory complexity. Two central concepts are arising: the unanticipated abundance of cis-antisense RNAs overlapping protein coding genes, and alternative transcripts resulting from a dynamic behaviour of operon structures (where genes can be included or excluded from a polycistronic transcript in response to environmental cues). Understanding these phenomena holds a great potential for our ability to decipher how bacteria regulate their complex life styles and pathogenic behaviours, but their dynamics, regulatory roles, and effects on combinatorially increasing the regulatory capacity of the genome are completely unknown. The primary objectives of this proposed research are: i) to understand the extent, regulatory roles, and evolutionary consequences of cis-antisense RNAs in prokaryotes; ii) to understand the regulatory code, combinatorial effects and dynamics of alternative operon structures; and, in parallel iii) to develop a unified framework for comparative prokaryotic transcriptomics. Our strategy is based on a combination of deep sequencing technologies, computational modelling and data analyses, systems biology approaches, and focused molecular biology experiments. We will identify the extent and the impact of these RNA-based regulatory layers in representative pathogenic and non-pathogenic species across the prokaryotic tree of life, study their functional and evolutionary consequences, and break the regulatory code controlling them. Our planned research has the potential of producing methodological and conceptual breakthroughs in the emerging field of prokaryotic transcriptomics.

Keywords: prokaryotic transcriptomics