Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Veterinary Validation of Point-of-Care Detection Instrument (VIVALDI)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Innovation actions
Countries involved: Italy,Germany,Sweden,France,Denmark,Denmark
Call: Validation of diagnostic tools for animal and plant health (H2020-SFS-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-04-30
Duration (months): 52.0
Total project cost (EUR): 3198508.79
EU funding (EUR): 2918817.84
Participants: 8
Project status: CLOSED

In the VIVALDI project the consortium will validate new equipment (the VETPOD platform) for rapid on-site detection of zoonotic pathogens in industrial food and animal production chains. The coordinator Technical University of Denmark (DTU) has developed the VETPOD platform based on Loop mediated isothermal amplification (LAMP) technology and optical read-out to a user interface, with disposable plastic cartridges (Lab-on-Chip, LOC) that can be adapted to an infinite number of assays for almost all pathogens. We have a portable LOC system with optical detection: a system with polymeric chip made by injection moulded with multiple (8-32) chambers suitable for rapid online or on site detection of pathogens. The polymer chip with multiple chambers is able to perform LAMP to detect different pathogens at species level from multiple (8-30) samples within 30-60 min. We want to validate the VETPOD platform for three important zoonotic pathogens: Avian Influenza Virus (AIV) or Highly Pathogenic Avian Influenza Virus (HPAIV), Salmonella spp. and Campylobacter spp. For HPAIV this will include identification of H types (H5 and H7), for Salmonella the identification of the most important serovars S. Enteritidis, S. Typhimurium and S. Dublin, and for Campylobacter species identification of C. jejuni and C. coli. The validation includes two stages: 1) Validation by national reference laboratories in DK, SE, IT and FR. Each NRL will involve 10 external labs for ring trials. 2) End-user validation at private labs (SMEs) in DE and IT. The equipment provider will prepare a business plan for sale of the VETPOD system. The private labs will prepare business plans for using the VETPOD platform for at site animal health detection as well as for online detection of zoonotic pathogens in food and animal production chains.

Keywords: ring trial,national reference laboratories,avian influenza virus,salmonella,campylobacter
Holistic Smart Integrated Pest Management by combining unique real-time smart pheromone based pest monitoring trap (ecoberTRAP) with novel cost-effective European pheromone production (ecoberSYTHESIS) (Ecofarming Synergy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-09-30
Duration (months): 10.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With 12M farmers and workers, agriculture plays an important role in the EU. Pests, pathogens and weeds are responsible for annual losses of 26-40%. Increasing concerns on the effects of pesticides on the environment, and most importantly, on human health, plus the raise of organic agriculture, result in an increased use of insect pheromones for both early-alert of plagues and assisted plague control via mass trapping. Pheromones have been already used for both pest monitoring and control, but a number of drawbacks prevent their wider use: slow and expensive production methodologies; and time consuming monitoring by existing traps (frequent visits to the fields needed). Ferimark 2016 provides: up to 82% cheaper pheromones produced in Europe and a smart trap which reduces farmers and public authorities visits to the field down to 1/6 of the current ones, which uses renewable energy and provides real time information to farmers and agricultural authorities via a mobile app. Ferimark 2016 developed and validated, ecoberSYNTHESIS, a novel synthesis method for fast and cost-effective (up to 82% cheaper compared to reported methodologies) production of a wide variety of pheromones; and designed ecoberTRAP, a novel IoT ready smart trap which reduces field visits down to 1/6, saving time and costs to end-users which uses our pheromones. Therefore, our holistic solution offers both pest early-alert, control, and monitoring and pheromone production under the same SME provider. During SMEInst-1, the SME will apply ecoberSYNTHESIS to the production of new pheromones and their certification, and will validate ecoberTRAP at European level (which also uses Ferimark 2016 very own pheromones produced in Europe) via new field tests. An elaborated business plan will be produced together with a route to SMEInst-2. As a result, following our circa 200 existing clients, the SME´s business plan shows €50.16M sales by 2023.

Keywords: pheromones
An RNA-based mechanism for the nutritional control of bacterial DNA replication initiation (NutriCoRe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

DNA replication is a fundamental biological process enabling the transmission of genetic information to progeny. In bacteria, its initiation involves a set of genes whose regulation is critical to ensure genome stability, both under optimal conditions and in response to environmental cues, including changes in nutrient availability. The highly conserved bacterial initiator protein DnaA has been proposed as a primary target for the nutritional control of DNA replication. Nevertheless, surprisingly little is known about the molecular mechanisms modulating its activity in response to nutrient limitation. Previous work showed that the synthesis and degradation of DnaA are both subject to control mechanisms that respond to environmental changes in the model organism Caulobacter crescentus. The 5’-UTR of dnaA mRNA was discovered to be required for the downregulation of the protein and the block of DNA replication initiation in response to nutrient depletions by a so far unknown post-transcriptional mechanism. Based on my preliminary in silico analysis I hypothesize that the 5’-UTR of dnaA can assume distinct conformations with different ribosome binding site accessibilities. Switching between these conformations is likely triggered by a trans-acting factor, either a small RNA, an RNA-binding protein or a metabolite, that is produced in response to nutrient availability. The present project proposal aims to elucidate the precise molecular mechanism underlying the post-transcriptional control of dnaA and to determine its consequences on DNA replication and cellular survival by combining classical biochemistry and genetics with cutting-edge molecular biology techniques. I expect that this work will contribute to the development of new strategies for bacterial growth control in industry and medicine. Importantly, the results of this study will provide key insights for the understanding of one of the most important biological processes: the regulation of DNA replication.

Keywords: caulobacter crescentus,dnaa,dna replication initiation,mrna,posttranscriptional regulation,metabolism,cell cycle,translation,ribosome binding site,nutrient,5 untraslated region,growth
Membrane-free Low cost high Density RFB (MELODY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Israel,Germany,Switzerland,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Advanced Redox Flow Batteries for stationary energy storage (H2020-LC-BAT-2019, 2019)
Start date: 2020-01-01
End date: 2024-03-31
Duration (months): 51.0
Total project cost (EUR): 3996612.5
EU funding (EUR): 3987612.5
Participants: 9
Project status: SIGNED

Redox Flow Batteries (RFB) are a key enabling technology for the energy transition. Mass market introduction of RFB’s has been hampered by various factors – material scarcity and cost (e.g. vanadium-based RBF), limited catalyst lifetime, membrane costs, system complexity and safety issues. The development of an economically viable, environmentally benign and sustainable redox-flow battery (RFB) storage systems is therefore eagerly awaited. The MEmbraneless LOw cost high DensitY RFB (MELODY) project will develop a sustainable RFB technology that is able to reduce the costs of electricity storage to an absolute minimum, even below the 0.05 €/kWh/cycle by 2030 as set out in the SET plan. MELODY employs a unique triple cost reduction strategy on the conventional RFB concept while tackling all major technical issues in an integrated manner. The three key elements are 1) A membraneless flow battery concept 2) the choice for hydrogen and bromine 3) Simplified system design. This approach will results in the realization and operation technology for a practical membraneless H2-Br2 redox flow battery at industrially relevant scale (based on dedicated Cell, Stack and Balance of Plant development and piloting). Hereby MELODY will improve all elements that will be limiting after successfully eliminating the membrane (Electrode and electrolyte development, sustainability and techno-economic assessments). With an unrivalled low Levelized Cost of Storage MELODY’s solution is best positioned to change storage from a pure cost factor into a valuable business cases and will enable a wider integration of renewables in the European energy mix. To successfully complete all objectives as set out in the call, MELODY brings together a world-class consortium of SME’s (Elestor, PV3 Technologies, Vertech), industry (Shell) and academic leaders (TU Delft, Technion, University of Exeter, ETH Zurich) that has all required know-how and capabilities to complete the project.

Keywords: membraneless,hydrogen,bromine
Artificial Retrieval of Information Assistants - Virtual Agents with Linguistic Understanding, Social skills, and Personalised Aspects (ARIA-VALUSPA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Research and Innovation actions
Countries involved: Germany,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Multimodal and Natural computer interaction (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 2949318.76
EU funding (EUR): 2949317.7800000003
Participants: 8
Project status: CLOSED

The ARIA-VALUSPA project will create a ground-breaking new framework that will allow easy creation of Artificial Retrieval of Information Assistants (ARIAs) that are capable of holding multi-modal social interactions in challenging and unexpected situations. The system can generate search queries and return the information requested by interacting with humans through virtual characters. These virtual humans will be able to sustain an interaction with a user for some time, and react appropriately to the user's verbal and non-verbal behaviour when presenting the requested information and refining search results. Using audio and video signals as input, both verbal and non-verbal components of human communication are captured. Together with a rich and realistic emotive personality model, a sophisticated dialogue management system decides how to respond to a user's input, be it a spoken sentence, a head nod, or a smile. The ARIA uses special speech synthesisers to create emotionally coloured speech and a fully expressive 3D face to create the chosen response. Back-channelling, indicating that the ARIA understood what the user meant, or returning a smile are but a few of the many ways in which it can employ emotionally coloured social signals to improve communication. As part of the project, the consortium will develop two specific implementations of ARIAs for two different industrial applications. A ‘speaking book’ application will create an ARIA with a rich personality capturing the essence of a novel, whom users can ask novel-related questions. An ‘artificial travel agent’ web-based ARIA will be developed to help users find their perfect holiday – something that is difficult to do with existing web interfaces such as those created by booking.com or tripadvisor.

Keywords: retrieval agents,affective computing,social signal processing
CliniSenz(TM) - A Cost-effective Biosensor for Automatic Continuous Blood Glucose Monitoring (CliniSenz)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We are a Swedish medical devices manufacture, Senzime AB, who have been driven by the need to take advantage of an existing core technology to embark on a new strategy to grow based on our vision of becoming the leading provider of analyte evaluation systems, with a turnover of €30.5m by 2020. To realise this vison we will add a new product line to our portfolio by exploiting an existing biosensor technology that we have developed, as well as the experience and contacts gained on a parallel project, which is currently yielding high growth. We have identified within our target market the need of health care providers to be able to track blood glucose levels continuously which is not currently being met in a cost effective and practical way by existing products. To overcome these deficiencies we have developed the CliniSenzTM system with innovative features and functionality which in turn creates performance advantages of being more sensitive, specific and continuous. These performance advantages, in turn generate real commercial customer benefits, such as reduced mortality rates, faster recovery rates and the freeing up of healthcare professionals. Since 2004 Senzime has been working to develop prototypes and has conducted clinical trials which has allowed us to have achieved TRL 6. We now seek to create a feasibility report and detailed business/investment plan which will enable us to secure funding to reach TRL 8 and launch the product. This new product will be key to realising our growth strategy relating to achieving growth in sales. Based on projected demand from ICUs across the UK and US, we have forecasted sales worth €30.5 million to us by 2020.

Keywords: glucose,monitoring,cost effective,continuous,healthcare,blood,faster recovery,high growth
Tracing the Invisible. Old Norse and Latin in medieval manuscripts. (Invisibilia)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

In the project “Tracing the Invisible. Old Norse and Latin in Medieval Manuscripts (INVISIBILIA)”, I propose to investigate bilingualism in medieval Northern Europe by focussing on the most popular media of the time: manuscripts. I will trace their Latin components, which have mostly been neglected in research until the present day, and make them accessible to the scientific community digitally, thus providing essential texts and finding aids for the Latin sections. I will analyse the interaction of the Latin with the Old Norse texts. By relating them to the production, dissemination and use of manuscripts by people from different social backgrounds, I will give a deep insight into the European literacy of medieval Icelanders and Norwegians in the time span ca. 1100 – ca. 1500. INVISIBILIA will focus on the manuscripts held in the Arnamagnaean Collections in Copenhagen and Reykjavik, which represent approx. 90 % of the total number of Old Norse codices. Any exemplar containing both Old Norse and Latin as clearly distinct entities will contribute to the corpus of the study, about 400 manuscripts in total. I will approach this corpus according to three major research objectives, namely a full catalogue of the Latin entities, a comprehensive multi-level edition, and a comparative study. The results of the three research objectives will be integrated in an enhanced publication, realising the latest developments in Digital Humanities. This open access, on-line website will exchange data with existing scientific databases and make it possible for other scholars to collaborate actively. By spanning the borders between Traditional and Material Philology, Cataloguing and Editing, and Traditional and Digital Humanities, INVISIBILIA reaches out to scholars of medieval Scandinavia and Medieval Latin alike. The research results will be directly comparable to other pre-modern bilingual literary systems and challenge the isolationism still found in Old Norse-Icelandic scholarship.

Keywords: manuscript studies,bilingualism,digital editions
European Concept of operations for Higher airspace Operations (ECHO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Italy,Germany,Italy,Belgium,France,France,France
Call: Enabling Performance by Innovation in Air Traffic Services (H2020-SESAR-2019-2, 2019)
Start date: 2020-11-01
End date: 2023-01-31
Duration (months): 27.0
Total project cost (EUR): 3119118.75
EU funding (EUR): 1968865.0
Participants: 12
Project status: CLOSED

The Higher Airspace region is located between the airspace normally used by aircraft and the beginning of space. Higher airspace is no longer an exclusive transition zone, but an area where operations will be significantly expanded as a result of the emergence of a complete new aviation domain, business and technical opportunities and more, representing business values in the order billions per year. The anticipated operations in the Higher Airspace represent an emerging market like for the early days of aviation where providing rules, including structural procedures regarding traffic and operations management, is now considered as the key enabler of this international healthy business of $900b/y which worldwide connect people and civilisations. The ECHO (European Concept of Higher airspace Operations) Project will deliver a comprehensive demand analysis and a comprehensive, innovative and feasible Concept of Operations enabling near term and future Higher Airspace operations in a safe and orderly manner. The Higher Airspace including the operators forms a new, almost legacy free environment enabling an expeditions uptake of innovations or, extrapolated SESAR solutions. In this way the Higher Airspace could become an incubator environment for future ATM. The ECHO project deliverables will also be instrumental in developing a Global performance based framework and will be the basis for the European Regulatory Framework. For this the project includes all the key European actors and includes extensive coordination and consultation activities, such as three large Thematic Work Shops, to ensure wide European Stakeholder buy-in and alignment with evolving European policies. The project will pave the way for the economic development of various commercial concepts that will only be possible by using the Higher Airspace environment.

Keywords: higher airspace traffic management,concept of operations,demand analysis,interface space traffic management,hyper sonic,super sonic,commercial space,haps
Advance in Proteomics and Analysis of dyes and Recovery of Charred and Aged textiles (PARCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

The analysis of archaeological textiles is a challenging undertaking. These precious remains have been altered to the point that discerning their composition requires the development of high specialised analytical tools, characterized by high sensitivity and great versatility. In different sites, many textiles have been excavated, some well-preserved, some with signs of carbonisation; in some cases, traces of colour are still visible. PARCA project proposes to join forces between dye analysis and proteomics to develop an innovative streamlined protocol that would combine dye and protein analysis in a single extraction to minimise sampling size while maximising the amount of information obtained. It will be achieved through the most up-to-date methodologies and instrumental developments of Liquid Chromatography-Orbitrap-Mass Spectrometry to develop protocols that will be applicable to the most degraded archaeological textiles. The LC-MS data will be correlated with FTIR and SEM analyses, to determine the threshold of protein survival by non-destructive techniques prior to proteomics. The project will be carried out for the first 2 years at the Smithsonian Institution (Washington DC-USA), in the proteomics lab under the supervision of Dr. Caroline Solazzo. The third year, incoming phase, will be carried at Sapienza University of Rome, under the supervision of Prof. Roberta Curini. At the end, archaeological relics from the Mediterranean basin will be analysed, in particular samples from Pompeii and Vesuvian areas and from Greek areas. The success of this project will result in gaining new experience in the analytical characterization of ancient textiles, by enriching my background on dyes with the acquisition of a very high level of skills in the field of proteomics and in high resolution mass spectrometry. This knowledge will allow me to reach a leading profile as independent researcher and to strongly strengthen my position in the field of Cultural Heritage Science.

Keywords: proteomics,dyes,cultural heritage,new methodology,extraction protocol,mass spectrometry,textiles,archaeological textiles