Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nano-Scale Protective Oxide Films for Semiconductor Applications & Beyond (NANO-PROX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Conventional demands for development in semiconductor industry are changing as the Moore’s Law approaching to its limits. Continuous decrease in the size of the transistors is coming close to atomic levels creating a fundamental barrier for further process developments as the semiconductor manufacturing is established today . Growth of thin films and inherent stress development within the film and film/substrate interface are critical for multiple phases of microelectronics manufacturing. Particularly, protective oxides of metal films are foreseen to have wide applications as (i) an interfacial layer to improve the adhesion and/or limit penetration of reactive chemicals of a deposited film (ii) as a subtractive layer to achieve selective material removal and (iii) as a nanofilm with inherent self growth limiting capability that could be used for nanoscale electronics manufacturing. Fundamental understanding of the proposed research is expected to be utilized in many other fields such as in biological systems to improve corrosion on bio-implants and, applications in which the interface and thin film properties affect permeation of reactive chemicals such as fusion reactor design or as ferroelectric capacitors where hydrogen permeation detoriates device functionality. Dr. Basim, the Principal Investigator of this study has been actively involved in semiconductor research and development for more than ten years at major semiconductor companies in US. Her expertise is on integration of newly adapted semiconductor processes, defect reduction during manufacturing and chemical and mechanical interactions on thin films. She will initiate her research at Ozyegin University, Mechanical Engineering Department with the support of the IRG funds if awarded. Dr. Basim’s new appointment at Ozyegin University is expected to bring all these expertise and experience to E.U. to promote the ongoing research and development.

Keywords: nano-electronics,ultra-thin films,self protective oxide film,thin film characterization and integration at system level
Pathway-based Secretomes in Breast Cancer Biomarker Discovery (PATHSEC-BCA-BM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-05-01
End date: 2014-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Improvements in the characterization of human tumors have resulted in better survival rates for cancer patients. However, less progress has been made in the development of clinical tools to monitor the course of the disease. Tumor markers have not had a broad acceptance in the clinical community, because the few that are known are organ rather than tumor specific. Proteomics biomarker discovery research is usually a brute-force effort, and suffers from lack of reproducibility and high biological sample complexity. There is need for proteomics hypothesis-driven biomarker discovery approaches that incorporate technology advances with understanding cancer at the molecular level. I propose a biomarker discovery approach that combines exploiting the tumor cell’s communication with its microenvironment and with the rest of the organism, with a proteomics method designed to specifically measure secreted proteins (the ‘secretome’). My hypothesis is that signaling pathways are altered during tumorigenesis, and that these alterations are translated into protein differential secretion, which potentially can be used to discover secreted markers. The strategy proposed entails generating breast cancer secretome signatures and mine them to discover secreted pathway-based biomarkers. There is great hope that the discovery of pathway-based biomarkers in breast cancer secretomes will facilitate individualized diagnostics and treatment of breast cancer patients.

Keywords: proteomics,tumor biomarker,breast cancer,cancer diagnostics
Pollution of air in the extended region of Athens: Space-based Nitrogen Dioxide (NO2) observations and their comparison with remote and ground–based measurements and modeling simulations. (PARTHENO2N)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Nitrogen Dioxide (NO2) is one of the most important tropospheric pollutants leading to poor air quality and inducing climate changes. Public exposure to NO2 at urban environments is of great health concern as it is known to cause human respiratory problems. NO2 is one of the main precursors of the photochemical smog; it contributes to the acidification of the atmosphere, control the oxidation capacity of the atmosphere and affect locally its radiative forcing. In order to access the significance of these issues, a deep understanding of all relevant, physical and chemical processes, that control the atmosphere, is required. To this end, one of the most important steps towards filling the gap of knowledge on NOx relevant processes has been made recently, via space-based observations of the NO2 vertical column densities (VCD). “PARTHENO2N” focuses on the investigation of the abundances and the seasonal changes of the NO2 columns retrieved over the region of Athens and its surroundings from four different satellite instruments (GOME, SCIAMACHY, GOME-2 and OMI). In order to gain confidence in satellite observations, it is important to investigate, both qualitatively and quantitatively, their representativeness for different geo-locations. “PARTHENO2N” will provide, for the first time, a high quality intercomparison of the satellite data with various ground based, in situ and remote sensing, observations performed by: i) a novel multi axis differential optical absorption spectroscopy system (MaxDOAS) measuring both the vertical columns and profiles of NO2 ii) a Brewer-MK4 spectrometer used to retrieve column densities of NO2 and iii) in situ chemiluminescence analysers recording the nitrogen oxides mixing ratios. Lastly the validated satellite observations are going to be compared with the simulations of the well established chemical transport model (Oslo-CTM2) in order to improve our understanding concerning the effect of anthropogenic emissions in urban areas.

Keywords: atmospheric pollution,atmospheric chemistry and physics,remote sensing,observation systems (satellite and ground based),nitrogen dioxide (no2),gome,sciamachy,gome2,omi,maxdoas,brewer,athens
Impact of mitochondrial respiration efficiency on plant cell metabolism (RESPARA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Respiration plays a key role in the survival of aerobic organisms since it is providing ATP, the energy for the whole cell. The reactions leading to the synthesis of ATP are well known but the mechanisms by which mitochondrial respiration controls cellular functions is unknown, mainly because most mutants in respiratory enzymes are lethal. Two hypotheses have been formulated to explain how respiration activity affects the metabolism. As the product of respiration is ATP, the respiration rate has an impact on the ATP/ADP ratio and on the activity of enzymes using ATP. This control of enzyme activity by the ATP/ADP ratio is known as the adenylate control. Besides, the mitochondrial electron transfer chain (ETC) is producing reactive oxygen species (ROS) when electrons are lost during their transfer through the ETC. As ROS accumulation causes a modification of the redox status and triggers the reorganisation of cellular activity, therefore the influence of ETC activity on cellular metabolism via ROS signalling is another possibility. In plants, most of the mutants with impaired respiration are affected in complex I, the first enzyme of the ETC. These mutants have reduced ATP synthesis and enhanced stress tolerance, indicating that both the adenylate control and the ROS signalling are affected. This project aims to understand how respiration contributes to the control of plant metabolism. Several complex I mutants which possess different levels of remaining complex I activity are available in Arabidopsis. The production of ATP and ROS by the ETC will be investigated to characterise the respiratory defect caused by the reduction in complex I function. System biology approaches including transcriptomic and metabolomic will be use to highlight the mitochondrial signals causing a cellular response and elucidate the corresponding pathways with a special attention to the adenylate control and the ROS signalling pathway.

Keywords: plant physiology,mitochondria,respiration,signalling
Transgenic models of mammalian meiotic exit (PERRY/MII/TG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Fertilisation occurs when two highly specialised cells (sperm and egg) unite, causing an &apos;awakening&apos; of the egg, known as meiotic exit. During meiotic exit, a one-cell embryo (zygote) is formed that is totipotent - it can give rise to an entire individual. Given the fundamental nature of this event, it is remarkable that almost nothing is known about the regulation of meiotic exit in mammals. Ignorance about meiotic exit can and must be addressed; the mechanisms that underlie the period of meiotic exit impact all changes in cellular potency, including those predisposing to cancer and rationales for deriving induced pluripotent stem (iPS) cells and the emergent field of regenerative medicine in general. The present proposal addresses this gap in our understanding in mice that carry specified gene additions; transgenic mice. We propose to build new transgenic mouse models to study meiotic exit. They will uniquely allow us to visualise and manipulate the underlying processes that immediately follow fertilisation, including key meiotic events that include cytoskeletal rearrangement, cell cycle progression and chromatin remodeling. IRG support will accelerate acclimatisation and thereby foster reintegration of the applicant&apos;s laboratory following transition from RIKEN, Japan, to the Centre for Regenerative Medicine, Bath University, UK, after a 13 year absence from the EU initially supported by an EMBO Long Term Travel Fellowship to the US in 1996. Reintegration will strengthen the EU in powerful technologies, including piezo-actuated microinjection, and facilitate improved and novel approaches to the prescriptive genesis of stem cells such as iPS cells and research into cancer mechanisms. It will consolidate and extend collaborations within the EU, with Asia and beyond and deliver a head-start in an area of globally-recognised import. Accordingly, the present proposal coheres with multiple strategic aims of the European Commission Work Programme.

Keywords: natural sciences
Industrial applications of moving boundary problems (TMCRM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Moving boundary problems will be studied in the context of two practically important settings: melting of ice in gas flow channels of Proton Exchange Membrane Fuel Cells and plaque build-up in arteries (atherosclerosis). The problems are related in that they involve a liquid layer flowing past the moving solid boundary. As well as being mathematically challenging they also all have immediate and important applications. During the project mathematical models will be developed and analysed for each of these problems. The work will begin with simple one-dimensional models. Approximate analytical solutions will be sought and compared, when possible, against existing exact and numerical solutions. The methods will then be extended to deal with the more complex two and three dimensional formulations where exact solutions are not available. This problem is complicated by the fluid flow which must be coupled to the thermal problem. The work will be linked with experimental research projects involving collaborators of the proposed researcher. These projects will be used to guide the analytical work and verify any results produced. This research proposal is viewed as the starting point for a much broader vision. In the long-term it is hoped to build up an industrial maths (IM) research group within the CRM, with a strong emphasis on heat transfer, fluid flow and phase changes. This group will then develop ties with local and international industry and act as a link between academia and industry.

Keywords: moving boundary problem,stefan problems,pem fuel cells,atherosclerosis,industrial mathematics
Development of Functional Nanofibers by Electrospinning (NANOWEB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-05-01
End date: 2014-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Electrospinning is a technique for producing nanofibers by creating a continuous filament by exposing a polymer solution or polymer melt to very high electrical fields. Due to its versatility and cost effectiveness, electrospinning has gained wide use recently to produce functional nanofibers from different materials, which include polymers, polymer blends, ceramics, sol-gels and composite solutions. Electrospun nanofibers and their nanowebs have several remarkable characteristics such as very large surface-to-volume ratio, pore sizes in nano range, unique physical properties along with the design flexibility for chemical/physical functionalization by incorporating specific additives into nanofibers. The unique properties and specific functionalities of such nanofibers/nanowebs make them favorable candidates in many applications areas such as medical/biotechnology, filtration and membrane technology, functional textiles, sensors, energy, composite materials, etc. Nanofibers/nanowebs from various types of natural and synthetic polymers can be easily produced by electrospinning, yet, improvements and new functionalities are always desired in order to enhance the properties of these electrospun nanofibers/nanowebs and broaden their application areas. Herein, it is proposed to fabricate functional polymeric nanofibers/nanowebs containing specific additives (cyclodextrins, textile additives, antibacterials, etc) by using electrospinning technique. The aim of this project is to produce new functional electrospun nanofibers/nanowebs and investigate their properties for the development of multi-functional nanofibrous materials for applications in filtration, functional textiles, medical/biotechnology, etc. The research proposed here has an interdisciplinary nature in the field of chemistry, materials science, textile, biology and engineering.

Keywords: electrospinning,nanofiber,nanoweb,polymer,cyclodextrin,nanofilter,nanotextile
Protein S-Nitrosylation in Inflammation and Cancer (NO-CANCER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Chronic inflammation represents a major pathologic basis for many human cancers. Nitric oxide (NO) production is a hallmark of inflammation, and may play a significant role in inflammation-associated cancers. S-nitrosylation, the covalent attachment of an NO group to the thiol side chain of cysteine is a common mechanism for dynamic, post-translational regulation of most or all main classes of protein. Indeed, protein S-nitrosylation and denitrosylation have emerged as integral components of signal transduction pathways, and accumulating evidence suggests that deregulated S-nitrosylation contributes to a range of human pathologies. Yet, the involvement of protein S-nitrosylation/denitrosylation in inflammation-related cancer remains unclear. To elucidate the role of protein S-nitrosylation in inflammation-associated cancer we will employ models of lung cancer, where we will characterize the S-nitrosylated proteome, investigate denitrosylation mechanisms, and study the redox regulation of central mediators of inflammation. We focus on three areas of research: (1) advanced redox proteomics for the identification S-nitrosylated proteins in lung tumour cells and in lung macrophages; (2) characterization of the regulation by S-nitrosylation of key inflammatory mediators, particularly, the inflammasome; (3) investigation of mechanisms and consequences of protein denitrosylation in lung cancer cells.

Keywords: oncology,chronic diseases,cell biology
Mechanisms of immune surveillance of senescent cells (SENESCENCE CLEARANCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cellular senescence, a stable form of cell cycle arrest, is a mechanism limiting the proliferative potential of cells. Recent studies demonstrate that cellular senescence imposes a potent barrier to tumorigenesis and contributes to the cytotoxicity of certain anticancer agents. In addition to sites of persistent damage and precancerous lesions, senescent cells have also been observed in tissues of aged individuals and can contribute to decline of tissue function with age. Therefore, mechanisms responsible for control over presence of senescent cells play central role in cancer prevention and aging. In my post-doctoral training I was first to demonstrate that cellular senescence protects against liver fibrosis, and that senescent cells can be cleared by the innate immune system to insure return to the pre-damage state. Components of the innate immune system, macrophages and NK cells were also demonstrated to clear senescent cell from tumors. However, molecular mechanisms of the recognition and the killing of senescent cells remain to be understood. Therefore, I propose to study contribution of NK cells and macrophages to recognition and elimination of senescent cells. Molecular mechanisms responsible for these interactions will be studied using engineered cell lines were senescence can be induced. Elaborate short hairpin RNA techniques will allow discovery of genes in senescent cells that are responsible for signaling to immune cells from one side, and from the other side identification of molecules in immune cells that can contribute to senescent cell elimination. Uncovering the mechanisms of interaction of senescent cells with the immune system will reveal the role of these interactions in diseases and aging and might ultimately lead to development of novel treatments.

Keywords: cellular senescence,cell biology,molecular biology
Gender Equality Through Women's Agency in state socialist Poland and Georgia (GETWA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-08-01
End date: 2014-04-03
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

This projects links the state socialist conceptualizations of gender equality with current struggles for women’s rights at national, regional and supranational level proposes new conceptualization of women’s agency under the authoritarian regimes and with limited access to international networking. It employs concepts of “gender equality”, “ women’s agency”, “state feminism” and “transnational women’s movement” as the major categories for studying the development of state equality projects and the impact of state socialism on the gender regimes in Georgia between 1921-1990 and in Poland between 1945-1989. This cross-national study of the state-socialist project of gender equality will apply interdisciplinary research methods including oral history, institutional ethnography, textual analysis and archival work to: 1.) destabilize existing paradigm of understanding the relationship between state socialism and post-state socialist gender relationships in terms of disruption and discontinuity, 2.) reconceptualize the notion of women’s agency under state socialism by recognizing socialist states as site for development of supranational women’s agenda, before Beijing Conference in 1995, 3.) deliver more comprehensive understanding of state socialist “gender equality” by recognizing the role that local political and cultural forces, religion and nationalism played in shaping and altering state socialist project of gender equality in various locations.

Keywords: social anthropology,political history,social changes,gender equality,social movements,women,poland,georgia,state socialism,state feminism,gender studies