Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improving global dust prediction and monitoring through data assimilation of satellite-based dust aerosol optical depth (DUST-GLASS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 164653.2
EU funding (EUR): 164653.2
Participants: 1
Project status: CLOSED

DUST-GLASS aims at improving global dust prediction and monitoring by optimizing an advanced data assimilation system (LETKF scheme) coupled with a sophisticated atmospheric-dust model (NMMB/BSC-Dust). For the accomplishment of these core scientific goals, a fine resolution (0.1o x 0.1o) global dust optical depth (DOD) database, suitable for data assimilation, will be developed via a synergy of state-of-the-art Level 2 satellite retrievals acquired by MODIS, MISR and OMI sensors (2007-2016). The impacts of assimilating this novel dataset (DOD) on model’s predictive skills, both at global and regional scale, will be assessed objectively. Global forecasts (5 days) will be carried out for different periods aiming at studying dust aerosols’ mobilization and transport from the major dust sources of the planet, while a global reanalysis (0.5o x 0.7o) dataset will be generated for long-term dust monitoring. In addition, regional short-term (84 hours) forecasts will be conducted for 20 Mediterranean dust outbreaks identified by a satellite algorithm in the framework of the MDRAF project (fellow’s previous MC-IEF). In the evaluation analysis, the model’s dust outputs will be compared versus measurements derived by ground networks (AERONET, MAN, ACTRIS) as well as against columnar/vertical satellite retrievals (MODIS, MISR, CALIOP). Moreover, temperature and radiation will be also considered since “corrections” on dust fields, thanks to data assimilation, are expected to be evident on both parameters due to dust-radiation interactions. The aforementioned variables will be compared against observations obtained by ground networks (ISB, RAOB, BSRN) and reanalysis/analysis products (ERA-Interim, FNL). Considering the multifaceted role of dust, the scientific outcomes of DUST-GLASS are expected to contribute effectively to interdisciplinary studies regarding dust aerosols as well as their associated impacts on health, anthropogenic activities, environment, weather and climate.

Keywords: data assimilation,atmospheric dust modeling,satellite retrievals,ground measurements,dust aerosols,dust optical properties
LIFEBOTS Exchange - creating a new reality of care and welfare through the inclusion of social robots. (LIFEBOTS Exchange)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Spain,Switzerland,Slovakia,Korea, Republic of,Norway,Greece,Belgium,Romania,Norway,Portugal,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-04-01
End date: 2025-01-31
Duration (months): 70.0
Total project cost (EUR): 768200.0
EU funding (EUR): 740600.0
Participants: 15
Project status: SIGNED

The project aims enhancing cross-sector, international and interdisciplinary collaboration in the area of social robotics technology for care. Are robots ready for society, and is society ready for robots? How can social robots can be included in people’s lives? Robots are increasingly being used in the healthcare sector as a potential solution to the current and future challenges faced by the healthcare sector. Due to the global population ageing, by 2035 the world is projected to lack 12.9 million healthcare professionals (WHO: 2013). Social robots may benefit the quality life and wellbeing of patients, their families and healthcare professionals. Evidence and much of the needed knowledge are still lacking. Strong interdisciplinarity and cross-sectorial research and innovation activity is needed. A knowledge hub for social robotics will be created with a threefold aim: (1) To enhance the competencies of involved staff members, refining and focusing their skills; (2) To build a tri-sectoral network involving academia, industry and users of technology, and (3) to create an enduring network that will outlive the grant funding. The core of the project includes some of the strongest actors in international research, SMEs and user organisations, focusing on three activity lines: technological, sociological, care-and-welfare. To be able to understand the impact of introducing social robots in care, the three areas that will be affected by this technical evolution will be researched: (1) care provided as medical practice; this is the care given to patients in hospitals, clinics, rehabilitation centres and other medical facilities. (2) residential care - this area refers to all care institutions accepting patient/clients as residents: elderly homes, nursing homes, special needs schools for children or adults, etc. (3) family care, investigating how social robots can be implemented in the home, and as a part of domestic life.

Keywords: social robots,health and care,home care,socially aware navigation,dialogue management,distributed cognitive robotics,domestication of social robots
Reprogramming of small RNA function in plant-pathogen interactions (PATHORISC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2022-04-30
Duration (months): 60.0
Total project cost (EUR): 1987811.0
EU funding (EUR): 1987811.0
Participants: 1
Project status: CLOSED

RNA silencing relies on small RNAs that act in RNA induced silencing complexes (RISCs). RISCs use base pairing to select mRNAs or invading nucleic acids such as viruses for repression. RNA silencing may facilitate gene expression changes, for example in host-pathogen interactions. Such changes require reprogramming of RISC, since a different set of RNAs must be rapidly repressed upon pathogen perception. RISC reprogramming is non-trivial: new small RNAs must be produced and be rapidly incorporated into RISC, while unwanted repression by pre-existing RISCs must be eliminated. This project focuses on understanding three central aspects of RISC reprogramming in plant-pathogen interactions. First, we will define mechanisms that allow invading RNA, but not self-RNA, to engage in positive feedback loops for small RNA synthesis, and we will investigate the specific importance of these positive feedback loops in antiviral defense. Second, we will explore how rapid proteolysis of the central RISC component ARGONAUTE1 (AGO1) governs rapid incorporation of newly synthesized small RNA. We will also explore the hypothesis that non-RNA bound AGO1 is degraded to minimize vulnerability to pathogens that use small RNAs as virulence factors to repress host immune signaling. The relevance of these mechanisms of AGO1 proteolysis in plant immunity will be investigated. These studies take advantage of our recent discovery of proteins required specifically for turnover of AGO1. Finally, we explore the hypothesis that rapid chemical modification of mRNA by N6-adenosine methylation (m6A) may bring mRNAs with poor small RNA binding sites under RISC repression. This scenario is supported by interactions between m6A reader proteins and AGO1 discovered in current work in the group. This mechanism may enable reprogramming of RISC specificity rather than composition upon pathogen perception. Our project will fill gaps in knowledge on RNA silencing and elucidate their importance in plant immunity.

Keywords: rna silencing,arabidopsis,plant pathogen interaction
Exploring gender equality in Irish higher education: Qualitative case-study research into the response to, and process of Athena SWAN (GendeResearchIreland)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2023-01-01
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

It has been shown that gender equality interventions in the higher education sector are vital in addressing career advancement challenges facing female academics and researchers, in particular the higher up the career ladder researchers progress. This proposed research would explore a gender equality intervention, Athena SWAN, which seeks to encourage commitment to advancing the careers of women in science. It has been shown that barriers to career advancement are mainly due to institutional factors, rather than individual ones, such as career drive or skill. Strengthening research and innovation in Europe, with respect to encouraging gender diversity to support science excellence and relevance, is an identified priority of Horizon 2020. This proposed study would explore the response to, and processes of, the Athena SWAN programme in one European country, Ireland. With a number of EC funded projects in Europe, and research growing, the time is ripe for conducting this research and informing the developing theoretical and policy context for gender equality in higher education in Europe. Athena SWAN is a new intervention in Ireland (since 2015) and this novelty in the process, alongside the context of change within institutions, would elicit a wealth of qualitative data findings that would be generalisable across European institutions. Given my expertise in qualitative research methods and participation in a FP7 gender equality project, I am in the best position to restart my career in this field of inquiry, within a highly stimulating and renowned social science research environment. Supporting this original research would result in a wealth of useful findings for peer researchers, the policy sector and the wider research and innovation community in Europe, as well as engaging with the public. I would seek to promote the Fellowship with a zeal reflecting the sentiment of the extraordinary woman in science who inspired this programme, Dr. Marie Skłodowska-Curie.

Keywords: gender equality intervention,higher education
Deciphering the molecular mechanisms of HIV DNA nuclear import and the impact of 3D genome organization on integration site selection (RetroChrom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA functions, primarily transcription. During retroviral infection, histone-free viral DNA copy is synthesized from viral genomic RNA. vDNA will ultimately integrate into the host genome to ensure its maintenance and expression. Understanding retrovirus-host interactions at the genomic level, and the peculiar mechanisms by which lentiviruses, including HIV-1, and their related gene transfer vectors, are imported into the nucleus, loaded with nucleosomes, integrate in, and interact with, the human genome will provide valuable information about lentiviral replication and establish the basis for the development of safer and more efficacious lentiviral vectors for human gene therapy. Our objectives are: 1-To identify and characterize cellular proteins associated with the HIV-1 PIC, and determine their roles in nuclear import and/or integration. 2-To explore the role of the epigenome of unintegrated vDNA in HIV-1 gene expression from unintegrated and integrated vDNA. 3- To determine the impact of nuclear organization on integration site selection and on viral and host transcription. State of the art technologies will be applied to achieve these challenging objectives. If successful, this project will make an outstanding contributions not only to the field of HIV biology but also for the development of safe lentiviral vectors for gene therapy.

Keywords: nuclear import,epigenome,3d genome structure,integration sites selection,gene therapy
Molecules Inhibiting Translation in Cancer cells (MITiC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

YB-1 is one of the major mRNA binding proteins and a master regulator of translation in cancer cells. It has been recently considered as a therapeutic target for the treatment of cancer and drug-resistant cancer. However, no small molecules with high affinity and specificity against YB-1 have been proposed so far, and the structural data essential to interrogate their relevance are missing. Understanding the function of translation regulation systems in order to design drug candidates is a very delicate procedure that requires a high level of accuracy and state-of-the-art techniques. Based on a promising preliminary finding of an active compound, we will focus in depth on studying the inhibition mechanism of YB-1 in order to help design new anti-cancer drugs able to overcome drug resistance. The research approach developed in this context aims to use in synergy advanced computational and experimental techniques while overcoming all limitations in a concerted way. This work is concerned with providing a sufficiently accurate computational model that is computationally efficient, specific experimental data and combining them with data mining techniques, for a molecular-level characterization of the inhibition dynamics and thermodynamics. This project is based on a multidisciplinary approach that requires knowledge of biology, biochemistry, physical chemistry, theoretical chemistry and bioinformatics in order to contribute to the medicine of the future.

Keywords: yb 1,cancer,drug design,nmr spectroscopy,microtubule bench,molecular dynamics,free energy simulations
Schools as Living Labs (SALL)

Framework: Horizon 2020 — Science with and for Society
Programme: Encourage citizens to engage in science through formal and informal science education, and promote the diffusion of science-based activities, namely in science centres and through other appropriate channels
Action type: Coordination and support actions
Countries involved: Estonia,Spain,Israel,Cyprus,Belgium,Serbia,Croatia,Greece,France,Netherlands,Portugal,Luxembourg
Call: Open schooling and collaboration on science education (H2020-SwafS-2019-2-two-stage, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 1511362.5
EU funding (EUR): 1511362.5
Participants: 13
Project status: SIGNED

SALL proposes the living lab methodology as a new technique of unique value and possibilities for the development of open schooling activities linked to science learning. The project positions the technique of living labs as a new, powerful element of the impactful OSOS framework for open schooling, and demonstrates this through the use of the food system theme, due to its strong links to science education, current challenges, as well as ambitious European policy making. SALL brings together school communities, including teachers, students and their families, research institutions, science museums and centres, spaces of informal learning and open innovation such as existing living labs, as well as policy makers, and engages them in intensive dialogue, mutual learning and exchange, so as to: a) co-construct the proposed living-lab-based open schooling methodology, by building on existing knowledge and best practices as well as on the power of synergy in the stakeholder community of contemporary science education; b) closely study living-lab-based open schooling practices and their impact, through implementation and evaluation in real-life conditions in school communities in different European countries; and c) prepare the ground for sustainable living-lab-based open schooling activities in Europe’s schools after the end of the project, through strong community-building, networking, dissemination, as well as policy-oriented interventions. In this way, SALL proposes a concrete new way for schools across Europe to approach their science education programmes, in order to make STEM teaching more relevant, systemic and inclusive for their students, collaborating with their local communities and research centres, and with the active support and involvement of science centres and museums in this process.

Keywords: open schooling,living labs
Boost BLUE economy trough market uptake an innovative seaweed bioextract for IODINE fortification (BLUE IODINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Portugal
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objective of the project is to produce in a cost effective way new high quality seaweed iodine products and become market leaders in this niche market. The expected revenue in 5 years will be 3,3 million euro and we expect to increase our staff in 20 people. Iodine deficiency is one of the three most common nutritional deficiencies and is spread all over the world and 40% of the world’s population remains at risk for iodine deficiency. Seaweed is the most reliable source of natural iodine. However, seaweed creation is dominated by larger players, mainly from Asia. Our strategy is not to compete with them, but target for a niche market that is yet incipient - high quality seaweed creation for the development of natural protein products, rich in essential aminoacids and natural iodine. The seaweeds created in the fish aquaculture farms are autochthonous from our region and have a high iodine content and a high degree of stability. They are better than the products in the market (iodine composition 30% higher and vitamin C 300% higher than usually commercialized seaweed products) and with our already tested innovative biorefinary process we will be able to put the product in the market at a competitive price (10% to 30% lower).A nutritional analysis has been done. The biorefinary process has been developed for small production. This has now to be better defined in order to process a higher amount of product UBQ is a high-tech company, and are specialized in the production of natural extracts obtained from marine seaweed. For the 1st stage project, the objectives are to study the: 1.1. Refinement of the nutritional and biochemistry analysis of the selected seaweed 1.2. Requirements for upscale the innovative biorefinary process for a higher production 2.1. Refinement of the Market analysis at EU and global level 2.2. Business Plan, including defining in detail the prices, commercialization strategy, possible partnership.

Keywords: seaweed,iodine deficiency
PAN EBOLA VACCINE INNOVATIVE APPROACH – Sofia ref.: 116088 (PEVIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Italy,Switzerland,Tanzania, United Republic of,Switzerland,France,France,France,Benin
Call: Ebola and other filoviral haemorrhagic fevers (Ebola+) programme: future outbreaks (H2020-JTI-IMI2-2015-08-single-stage, 2015)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 17731397.75
EU funding (EUR): 6189570.0
Participants: 15
Project status: CLOSED

Ebola virus (EBOV), a member of Filoviridae family of viruses, is one of the most dangerous microorganisms in the world, causing severe hemorrhagic fevers in humans and non-human primates with high case fatality. Since its discovery in 1976, five different Ebola virus species have been isolated and over 20 sporadic EBOV outbreaks have occurred, mostly confined to rural areas in East and Central Africa. Hence the disease did not attract much global attention. However, the 2014 Ebola outbreak in West Africa, caused by Ebola Zaire strain, gained widespread attention as it took a different pattern and has reached historic proportions, characterized by a rapid and larger spread beyond Africa, and a greater magnitude than all the other outbreaks combined, underscoring its serious threat to the public health. No vaccines or antiviral drugs currently approved for prevention or treatment of Ebola infections in humans. However, the severity of the recent Ebola outbreak and the potential risk of global spread, has spurred research for the rapid development of safe and effective preventive Ebola vaccine. Such a vaccine, that can rapidly induce strong and long-lasting protective immune responses against all main Ebola strains and that can be readily produce and deployed in the field, is needed to protect people in endemic regions in an event of an outbreak but also to protect healthcare workers caring for Ebola patients, who are at the highest risk of infection even before an outbreak can be identified. A number of EBOV vaccine candidates are under development and some have been shown to induce protective immune responses against lethal Ebola virus infection in different animal models, including non-human primates. In response to the recent Ebola outbreak, three main promising monovalent vector-based vaccines are being investigated in human clinical trials, demonstrating their safety and immunogenicity and the potential efficacy of a Vesicular Stomatitis Virus-based vaccine

Keywords: thermostable pan ebola vaccine prime boost vaccination strategy antibody and t cell,immunity smes innovative functional analysis tools,novel in vitro and in vivo diagnostics,new adjuvant s