Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synthesis of Natural Product Like Compounds for Drug Discovery (NPL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: TERMINATED

This proposal deals with the application of Dr. Francisco Cardona for a fellowship to work on the design and synthesis of new macrocyclic natural product like compounds (NPLs) which have potential in chemical biology or drug discovery at NUI Galway. A training programme has been designed for Dr. Cardona to enable him to broaden and deepen his professional knowledge and develop complementary skills that will mature him as a researcher. The project involves the innovative synthesis of new NPLs based on novel macrocycles. The main objective from the scientific point of view is to prepare new scaffolds that have not been explored to date and to generate compounds for screening in a wide variety of bioassays. This will determine if the scaffolds are relevant for developing therapies to cancer or infection, for example. There is a need for this research in that industry and academia have focused for a long time on a limited number of scaffolds and drugs have been based on a limited number of frameworks. In this research the applicant aims to increase the number of frameworks available and to also develop routes that are concise. Compounds will be evaluated for their biological properties within the project and managed for shipping to collaborating researchers for screening. Dr. Cardona will broaden and deepen his professional expertise, gain knowledge of screening and interpretation of biological results and of approaches in medicinal chemistry. This professional knowledge will increase the researchers capacity to contribute to related projects in industry or academic or research organisations later in is career. They will undertake a programme of complementary skills training to enhance relevance to future employers. The host is committed to ensuring that the relationship with the researcher will be conducive to successful performance in generating, transferring, sharing and disseminating knowledge and technological development.

Keywords: macrocycles
From residual steel gasses to methanol (FReSMe)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Iceland,Spain,Romania,Sweden,Sweden,Slovenia,Sweden,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands
Call: Utilisation of captured CO2 as feedstock for the process industry (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-11-01
End date: 2021-06-30
Duration (months): 56.0
Total project cost (EUR): 11406725.0
EU funding (EUR): 11406725.0
Participants: 13
Project status: CLOSED

The FReSMe project, From Residual Steel gases to Methanol, will produce a methanol that will be demonstrated in ship transportation. This green fuel will be produced from CO2, recovered from an industrial Blast Furnace, and H2 recovered both from the blast furnace gas itself, as well as H2 produced by electrolysis. The two different sources of H2 will enable (i) maximum use of the current residual energy content of blast furnace gas, while at the same time (ii) demonstrating a forward technology path where low carbon or renewable H2 become more ubiquitous. The project will make use of the existing equipment from two pilot plants, one for the energy efficient separation of H2 and CO2 from blast furnace gas, and one for the production of methanol from a CO2-H2 syngas stream. This can be realised with a small amount of extra equipment, including supplemental H2 production from an electrolyser and a H2/N2 separation unit from commercially available equipment. Methanol is a high volume platform chemical of universal use in chemical industry as well as applicable for fuelling internal combustion engines. As such it provides a promising pathway for the large scale re-use of CO2 to decarbonize the transportation and chemical sectors in Europe and decrease the dependence on fossil fuel imports. Production of methanol from CO2 offers the unique combination of scale, efficiency and economic value necessary to achieve large scale carbon reduction targets. The pilot plant will run for a total of three months divided over three different runs with a nominal production rate of up to 50 kg/hr from an input of 800 m3/hr blast furnace gas. This size is commensurate with operation at TRL6, where all the essential steps in the process must be joined together in an industrial environment. The project will address the new integration options that this technology has within the Iron and Steel industry and contains supplementary and supporting research of underlying phenomena.

Keywords: methanol,blast furnace gas,iron and steel,fuel upgrading,co2 utilization,pilot plant,industrial environment,scale up,end user demonstration,complete value chain,decarbonised fuel
KOALALIFTER: WIND CRANELESS SYSTEMS (KoalaLifter)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-06-01
End date: 2023-04-30
Duration (months): 35.0
Total project cost (EUR): 2900233.0
EU funding (EUR): 2030163.0
Participants: 1
Project status: SIGNED

LEUNAMME has developed the KoalaLifter System, a disruptive lifting device that uses the Wind Turbine Generator (WTG) tower as a support, having an autonomous self-climbing capability. Therefore, there is no need for auxiliary cranes, making the system virtually independent of the tower height, weight to be lifted or wind speed limits. We have four international patents protecting KoalaLifter technology. Every year more than 18,000 new turbines are installed, and around 20,000 maintenance operations are carried out, which represents considering a small penetration of 6.9% (WTG maintenance) and 11.9% (WTG erecting) on 2025 a potential revenue for KoalaLifter of €86 million. KoalaLifter EIC Accelerator project aims to cover the gap between the current TRL6 level up to TRL9 stage. Main objectives are (i) to extent product range; (ii) to validate and certify products and processes; (iii) to prepare for commercialization; and (iv) to protect, exploit and communicate our solution. After raising funding from capital funds and bank loans, we are at the limit of our possibilities to raise quickly the additional €5.7 m to accelerate the finalization of our solution and be ready to commercialize it internationally in only two years; an EIC Accelerator blended funding will allow to achieve those goals.

Keywords: wind,turbine,green,energy,tower,erecting,maintenance,lcoe,efficiency,versatility,renewable,robot,mechatronics
ZeNewCardio: Discovering Heart Regeneration Therapies Through Zebrafish (ZeNewCardio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Ischemic heart disease is a leading cause of death worldwide. However, heart transplantation is risky, plus the number of donors does not cover the demand of patients, and alternative treatments are inefficient. Given that adult mammalian hearts display insufficient regeneration capability to allow complete myocardial recovery, a promising treatment after infarction could be the identification of molecules unblocking cardiac self-healing/regeneration. In that sense, zebrafish displays life-long ability to regenerate its heart after damage. Interestingly, the same genetic programs promoting cardiomyocyte dedifferentiation and proliferation after injury in zebrafish are present, albeit dormant, in the adult mammalian heart. This makes zebrafish a powerful model to unravel key molecular pathways that might induce heart regeneration in humans, if activated. Here, we propose the development of ZeNewCardio: a high-throughput preclinical platform using the zebrafish model to find suitable treatments for heart regeneration after ischemia. The project aims are: 1) to implement cardiac injury models in zebrafish; 2) to use these models to identify genes involved in heart regeneration, with a focus on genes enabling cardiomyocyte dedifferentiation/proliferation; 3) to use the gathered knowledge to discover novel cardiac pro-regeneration drug therapies applicable to humans. Our genetic and analysis tools will speed-up the process of target validation of novel gene regulators of regeneration, based on the stimulation of endogenous regenerative responses, and the discovery of new drug therapies to treat or protect ischemic hearts.

Keywords: zebrafish,cardiac regeneration,drug discovery,transgenesis,heart ischemia
EXPLORATHON'16 and EXPLORATHON'17 - EUROPEAN RESEARCHERS' NIGHT SCOTLAND (EXPLORATHON-4D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-06-01
End date: 2018-01-31
Duration (months): 20.0
Total project cost (EUR): 438956.25
EU funding (EUR): 183387.0
Participants: 5
Project status: CLOSED

EXPLORATHON-4D will deliver two exciting editions of European Researchers' Night across Scotland in 2016 and 2017 guided by our ethos of 'Research for All'. Our partnership builds on our successful, highly visible, EXPLORATHON concept which reached over 15,000 people live and achieved over 4-million twitter impressions in 2014 and 2015. Led by five of Scotland's major research-intensive universities with over 600 EU-funded research projects between them, EXPLORATHON-4D will bring research to the public and foster a new dimension of collaboration with business and industry, building on themes of careers and Responsible Research and Innovation (RRI). Our headline - ONE NIGHT, UNLIMITED DISCOVERY - provides a public friendly message designed to engage audiences not traditionally interacting with research or researchers. We are benefiting from our nationwide partnership to introduce robust researcher training ahead of the NIGHTS ensuring that researchers and publics have the best experience possible. At the heart of our proposal lies a vibrant, multi-element programme of activities and events, all designed to break down barriers between research and external actors of different backgrounds, ages and interests. Formats of cafe discussions, comedy, performance, hands-on activity, talks and debates will combine to highlight the relevance of research and challenge perceived stereotypes of researchers. Our venues will include public places such as shopping centres and cinemas but will also features 'doors open' access into research environments where discovery is actually happening, universities and industry. We will highlight the multidisciplinary and collaborative nature of modern research, helped by MSCA Fellows and EU-funded project exemplars. We will encourage young people to consider research as an exciting, challenging career option, telling the story of how investment in research is vital for driving innovation that addresses real life local and global issues.

Keywords: european researchers night,public engagement,research careers,ernscot
Emulsar: give the world appetite for health. (GWAFH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: France
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Emulsar is an innovative SME founded in 2004. Emulsar invented a breakthrough emulsion technology that allows the designing and manufacturing of disruptive innovations to revolutionize health and nutrition. Since 2012 Emulsar has produced hundreds of tons of Light oil® used to bring a whole new generation of ultra low-fat and healthier dressings with enhanced taste on the market. The combination of aging populations, more sedentary lifestyles and poor nutrition habits has created a huge raise in public health issues such as diabetes, obesity, Alzheimer, denutrition and cancer. Health goes through nutrition. Today, poor taste is one of the main criticisms heard about healthy functional food, and undoubtedly the major reason for poor consumption. Nutrition demands taste. Our objective and main motivation for this project proposal are to accelerate the deployment of our innovative manufacturing technology on a European & world scale by investigating functional food market opportunities. Emulsar’s mission is to improve the health impact of functional food through enhanced taste. The deployment of such a technology will lead to these outcomes: • identify the most valuables functional food products in terms of nutrition impact and business opportunity for Europe & the world • produce lab prototypes • generate market data to forecast turnover and ROI • build a strong business plan These outcomes will also lead to the following impacts: • positively modify patient and consumer perception of functional food • dramatically increase consumption of functional food in Europe and around the world • help solving chronic diseases and face the aging of population The objectives of phase 1 are to conduct a global market study and realize prototypes to be used as proof of concept. The success of phase 1 will lead to industrialize and commercialize our application in phase 2 and start developing new promising applications. Emulsar: give the world appetite for health.

Keywords: emulsion,nano emulsion,functional,food,nutrition,health,taste
Development of a New Wavelength Scanning Interferometer for Embedded Metrology (EMInstr)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-04-01
End date: 2016-03-31
Duration (months): 12.0
Total project cost (EUR): 149662.0
EU funding (EUR): 149662.0
Participants: 1
Project status: CLOSED

The proposed EMInstr project aims to elevate the important research result, a lab prototype of a new wavelength scanning interferometer (NWSI) developed during the ERC-2008-ADG 228117 SURFUND project and to verify its potential as a commercial product. The EMInstr project intends to set up a commercialisation pathway: from verification/validation of the lab prototype, through to technical optimisation, product prototype design, technological licensing and finally into commercialisation. The expected result of this project is to develop a new generation instrument, a pre-production NWSI, for embedded metrology. The NWSI represents a step-change in manufacturing metrology instruments, being the first of a new generation of micro/nano geometry and surface topography measurement systems. This revolutionary device is the result of integrating several advanced technologies, wavelength/frequency scanning, GPU electronics and a multi-interferometry configuration, to produce the NWSI with unique capabilities in high-speed, large-measurement ratio (range/resolution) and robustness.

Keywords: metrology,instrument,wavelength scanning interferometer,manufacturing
NANOARCHITECTRONICS (NANOARCHITECTRONICS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy,Italy,Italy,Germany,Spain,Italy,Belgium,Finland,France,France,Netherlands,United Kingdom
Call: FET-Open Coordination and Support Actions (H2020-FETOPEN-2-2016, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 670000.0
EU funding (EUR): 670000.0
Participants: 14
Project status: CLOSED

This FET-open Coordination and Support Action is called “Nanoarchitectronics” (NTX) to denote a new interdisciplinary research area at the crossroad of Electromagnetics and Nanoelectronics. NTX It is a new technology aimed at conceiving, designing and developing reconfigurable, adaptive and cognitive structures, sensorial surfaces and functional “skins” with unique physical properties, and engineering applications in the whole electromagnetic spectrum; through assembling building blocks at nanoscale in hierarchical architectures. The conception of this new area responds to the need of unifying concepts, methodologies and technologies in Communications, Environment Sensing Systems, Safety and Security, Bio-Sensing Systems and Imaging Nanosystems, within a wide frequency range. This FET project proposal gathers thirteen universities, research centers and high-tech industries, belonging to eight European countries. According to the FET work-program, the major objective of “Nanoarchitectronics” is to boost the future application-driven research through the establishment of an accepted language among physicists and engineers, a shared way of thinking, a common theoretical foundation and a common strategy for the future. Therefore, the project aims at laying the foundation for an ever-increasing synergy and progress of Nanoarchitectronics. To achieve these objectives, Nanoarchitectronics is structured in four main activities. The “Concept” activity is devoted to establish and define the concepts of Nanoarchitectronics and its boundaries with respect to other disciplines and to the activity carried out by other consortia. The “Strategy” activity identifies the policy dialogue and the strategic view of the consortium in terms of position, impact and vision. The “Virtual Networking” serves to internal web communication (private), and for dissemination (public). The “Dissemination and Exploitation” activity is carried out mainly by the industrial partners of the consortium

Keywords: nanoelectronics,electromagnetics,optics,photonics,multiscale modelling,antennas,metamaterials,quantum and condensed matter physics
Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography (NaWaTL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-06-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

This project deploys an innovative interdisciplinary mixed-methods approach to studying the cultural patterns of ancient Mesoamerican civilization. The study combines traditional comparative analysis of language history with quantitative phylogenetic methods, and with qualitative analyses from epigraphy and ethnohistory to answer a central question in Mesoamerican history: When and from where did the community of linguistic forebears of the Nahuatl-speaking Aztecs disperse in Central Mexico, and are they likely to have played a role in the development and/or downfall of the metropolis of Teotihuacan (ca. 150-600 CE)?

Keywords: mesoamerica,archaeolinguistics
Overcoming chromatin restricted DNA access (DNAccess)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 2302500.0
EU funding (EUR): 2302500.0
Participants: 1
Project status: SIGNED

Differential gene expression programs account for the diversity of cell types in our body. They are controlled by intricate networks of sequence-specific transcription factors (TFs) that operate in the context of chromatin. Chromatin is itself an essential component of this process, and is part of the system that selectively restricts DNA access for TFs. As a consequence, most TFs only bind to a small subset of their motif occurrences, in a way we currently do not fully understand. Our inability to predict binding of a TF based on its cognate motif and location in the genome is a serious obstacle towards predictive models of gene regulation. DNAccess has the ambitious goal to define in vivo the sensitivities of TFs to nucleosomes and their reliance on chromatin remodeling enzymes for binding. Using novel genomics and genome editing tools we will: (a) systematically vary TF motifs, presence of nucleosomes and their modifications at a defined chromosomal locus and quantify resulting TF binding; (b) explore genome-wide the ability of ectopic TFs to engage with a chromatinized genome in the absence of host cofactor engagement; (c) dissect chromatin remodeler dependent TF binding in order to define temporal order and subcomplex function and (d) deconstruct remodeler recruitment by mutating TF interaction domains. DNAccess will build a highly integrated setup to comprehensively characterize how nucleosomes, their modifications and mobility restricts genome access. We will characterize existing chromatin barriers and identify how TFs overcome them. This represents a crucial step towards a comprehensive understanding of the role of chromatin in gene regulation, and will advance our understanding of how specificity is generated in large eukaryotic genomes.

Keywords: chromatin,transcription factor binding,nucleosomes,genomics