Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AI-powered platform for autologous iPSC manufacturing (AiPSC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands,Greece,Austria
Call: Emerging Technologies in Cell and Gene therapy (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 3999225.0
EU funding (EUR): 3999225.0
Participants: 5
Project status: SUSPENDED

Induced pluripotent stem cell (iPSCs) can be differentiated into any cell type of the body and transplanted without rejection. The potential of iPSCs to cure health problems including degenerative diseases, cancer, cancer therapy associated disease and defective tissues, is unprecedented in history. However, the current methodologies prohibit standardized production of person's own (autologous) iPSCs, hence rejection is taking place and the therapeutic promise is not fulfilled. Our consortium seeks to develop a new technology that will enable the mass production of personalized iPSCs for autologous adoptive cancer immunotherapies, hematopoietic stem cell transplantation, and tissue regeneration. The consortium will for the first time create an artificial intelligence (AI) guided microfluidic device that standardizes the GMP production of autologous iPSCs fast and at a fraction of the current cost. Moreover, it will conduct cutting-edge single cell genomics and bioinformatics research of iPSC to identify clones of highest quality, and develop a database that will be the basis for AI software to select clones that meet clinical standards. The consortium comprises of experts in microfluidics engineering process automation for cell therapies, stem cell molecular biology and bioinformatics, GMP production, and AI modelling. The participating companies, startups, and universities are amongst the leading in Europe, and will promote the positions of female and early career participants from developed and developing European countries. The consortium aims to reach TRL3 prototype stage, and have created a concrete exploitation plan to develop the technology further for implementation in cancer therapy and regenerative medicine. Altogether, we propose to create revolutionary technology for low cost, fast, and standardized automated mass production of autologous iPSCs, which holds the potential to enable numerous new therapies and making them accessible to the public.

Keywords: induced pluripotent stem cells engineering microfluidics artificial intelligence automation
Polymeric Cyclodextrin-Based Supramolecular Constructs Photoreleasing Nitric Oxide for Combating Antibiotic Resistance (SUPREME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Hungary
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-11-30
Duration (months): 28.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 3
Project status: CLOSED

With more than 13 million people dying per year from infectious diseases Multidrug Resistance (MDR) in bacteria remains the greatest challenge in public health care. This scenario, associated to the low turnover of new clinically approved antibiotic drugs makes the development of innovative therapeutic approaches to fight antibiotic resistance desperately needed to address this devastating societal problem. In this frame, SUPREME aims at the implementation of a novel strategy based on unprecedented supramolecular platforms based on new cyclodextrin polymers integrating light-activatable nitric oxide (NO) photodonors (NOPD), alone and in combination with antibiotics currently employed in the clinic. The final goal is to exploit the double role of NO generated with superb spatiotemporal control thanks to the light triggering, as: i) bactericidal species not suffering MDR when produced at high doses (micro molar); ii) inhibitor of the efflux pumps mainly responsible for MDR, when produced at low doses, to revert antibiotic resistance. Highly biocompatible branched polymers containing mixed (alpha, beta and gamma) cyclodextrin units will be used as suitable hosts able to self-assemble into nanoparticles or gels encapsulating the therapeutic cargo with high efficiency. We will focus on NOPDs activatable exclusively with the biocompatible visible light and on antibiotics representative of the classes of fluoroquinolones and tetracyclines, known to display resistance and severe side effects. Full chemico-physical and photochemical characterization of the systems is planned as well as assessment of their efficacy against planktonic microbial cells and biofilms. The complementary expertise of the researcher and the supervisor supported by the private and academic teams hosting the fellow during secondments will create a multidisciplinary environment where all participants will benefit from reciprocal transfer of knowledge.

Keywords: light,nitric oxide,cyclodextrin polymers,bacterial infections,mutidrug resistance
Integrating innovative theories and practices in historical culture and education (MAKINGHISTORIES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Denmark,Belgium,Cyprus,Italy,Estonia,Germany,Israel,Australia,Korea, Republic of,Canada,Costa Rica
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 552657.14
EU funding (EUR): 542800.0
Participants: 18
Project status: SIGNED

The central aim of this project is setting up a gender balanced, international, interdisciplinary and inter-sectoral network of organisations to produce new knowledge, both theoretical and applied, in the field of historical culture and education studies. This, in order to improve the role of historical representations in present democratic and reflective societies. Enveloping both formal and informal contexts, in which views on the past are disseminated, this field invites a closer collaboration of academics and practitioners working in historical museums, heritage environments, historical reenactments, memorial sites and schools. A total of 23 institutions in Europe, Africa, Australia, Canada, Israel and Latin America will be participating in MAKINGHISTORIES. Special attention will be paid to the presence of gender history in formal and informal educational environments and to how they could further develop in this respect. Also, the importance of understanding the challenges of globalisation and global history will be considered. In both cases, introducing these two rather new and innovative historiographical approaches has the purpose of contributing to the renovation of historical culture environments and the present uses of history representations. Furthermore, the project aims to study how innovative dialogical and multi-perspectivist practices might affect historical representations. This project will produce research articles, books and digital media (short videos, podcasts, audio-guides and multimedia history textbooks chapters) for disseminating and communicating these efforts, expanding a dialogical view of formal and informal contexts of history education. These digital media will be produced in the context of a CPD to improve skills of practitioners and that will continue to be on-line after the project is over, essentially contributing to the project’s self-sustainability.

Keywords: social influence,power and group behaviour,classroom management teaching and learning methodologies,pedagogy,andragogy,psychology
User-driven applications and tools for Climate-Informed Maritime Spatial Planning and integrated seascape management, towards a resilient & inclusive Blue Economy (OCEANIDS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Research and Innovation actions
Countries involved: Greece,Belgium,Germany,Finland,Spain,Poland,Romania,Lithuania,France,Portugal,Switzerland
Call: User driven applications and tools for regional and local authorities, and other end users focusing on climate impacts, data and knowledge. (HORIZON-MISS-2022-CLIMA-01, 2022)
Start date: 2023-12-01
End date: 2026-07-31
Duration (months): 32.0
Total project cost (EUR): 3096345.0
EU funding (EUR): 3096345.0
Participants: 27
Project status: SIGNED

OCEANIDS aims at building user-driven applications and tools, which act as an enabling technological layer for regional authorities & stakeholders in order to achieve a more resilient and inclusive systemic pathway to a Blue Economy in coastal regions. Brining spatial and non-spatial data & services under a single-access window platform for Climate-Informed Maritime Spatial Planning (CI-MSP), the project will allow a more integrated seascape management of coastal regions. The project delivers a Decision Support tool (the OCEANIDS Decision Support Platform - O-DSP), with an over-arching target to collect, harmonise and curate existing climate data services, making data accessible, reusable and interoperable for the development of local adaptation strategies. OCEANIDS facilitates access to knowledge, data & digital services critical for better understanding and managing climate risks, enhancing adaptive capacities and sup-porting transformative innovations. In addition, OCEANIDS sees inclusivity as an enabling, and required, factor towards a Blue Economy. The project has a strong focus on behavioural change, both on individual as well as on a systemic level, en-abling participating regions and communities to better understand and use potential social tipping points and systemic leverage points to accelerate transformative changes towards climate resilience. To achieve this, it promotes inclusive and deliberative governance through meaningful engagement and dialogue between citizens and stakeholders. This will be achieved using case-specific tools (i.e. ephemeral social networks) leveraging local citizens assemblies for bot-tom up deliberation, cultivating a culture of civic engagement, thus empowering individuals to take action in their own communities. Finally, the project will contribute to mobilising sustainable finance and resources towards adaptation at scale and closing climate protection gap.

Keywords: maritime spatial planning,msp,coastal regions,dss
ISOLATED SEAMOUNTS AS WINDOWS INTO UPPER MANTLE GEOCHEMICAL HETEROGENEITY (ISOSEA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Hundreds of thousands to millions of seamounts unrelated to hotspot activity remain unexplored at the seafloor, either as isolated seamounts or as clusters. Most of them are located at remote sites within the ocean basins and they are not influenced by deep mantle upwelling processes or subduction/back-arc regimes, thus their composition and mechanisms of formation are intrinsically related to the upper mantle compositional nature and dynamics. For many years, the upper mantle has been considered as a homogeneous and depleted reservoir, nevertheless, the ever-growing isotopic data available suggest that heterogeneities are pervasively present throughout the mantle. The ISOSEA project aims to characterize upper mantle heterogeneity using the composition of non-hotspot isolated seamounts and seamount provinces as a window into the upper mantle. Using an integrated approach including petrological, geochemical, and geochronological evidence from the seamount province located south of the Mid-Pacific Mountains as the main case study, we intend to characterize their mantle sources in an effort to understand what is the origin and composition of enriched upper mantle heterogeneities that allow the formation of seamounts unrelated to hotspot activity. The results of this study could help lead to a paradigm shift of the composition of the upper mantle: from considering it as an inherently homogeneous depleted reservoir to a possibly highly heterogeneous one, containing enriched, recycled lithospheric components. The outcomes of the ISOSEA project will have a strong impact on the European and International scientific community, since they can be used to assess targets for future expeditions to unlock the secrets of the seafloor – the final frontier on our planet.

Keywords: seamounts,isotope geochemistry,mantle heterogeneity,upper mantle,igneous petrology,intraplate magmatism,oceanic island basalts
Semantic V2X communications: a paradigm shift towards scalable V2X networks (SemanticV2X)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-02
End date: 2026-09-01
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Vehicle-to-Everything (V2X) communications are key for the transition towards a Connected and Automated Mobility (CAM) that is essential to accomplish the EU Green Deal vision of a safer, more efficient, and sustainable transportation. Like any existing communication system, current V2X communications focus on the reliable and timely transmission of signals without considering the relevance of the transmitted information. Such relevance-agnostic approach can lead to the transmission of unnecessary data that will challenge the scalability of V2X networks, especially in light of the increasing amount of V2X data that will be produced and consumed with the mass-deployment of Connected and Autonomous Vehicles (CAVs). In the SemanticV2X project, we take inspiration from the human language to redesign V2X communications by proposing a paradigm shift that makes the semantics of the information the foundation of the V2X communication process. We will capitalize on the semantic processing capabilities natively available in CAVs to develop a novel set of analytical and numerical semantic models that determine the relevance of the information for the intended receivers considering the target application(s) and leveraging a knowledge-driven representation of the communication context. SemanticV2X will leverage the semantic models to develop a novel semantic and goal-oriented V2X communication paradigm where CAVs curate the transmitted information based on its relevance for the intended receivers. The impact of semantic V2X communications on the scalability of V2X networks, as well as on connected and autonomous driving, will be assessed using a unique and advanced CAM simulator, system-level V2X simulations, and novel semantic KPIs. We estimate that semantic V2X communications can triple the capacity of V2X networks, effectively addressing the massive connectivity demands of CAM and contributing to the realization of its economic and societal benefits.

Keywords: v2x,vehicle to everything,semantic communications,connected and automated mobility,connected and autonomous vehicles,intelligent transportation systems
Developing a scalable production route for functional high performance in-situ TEM cells (G-WIN-TEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-04-01
End date: 2026-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

This project aims to revolutionize in-situ gas cell transmission electron microscopy (TEM) by scaling up the novel in-situ cells that have been pioneered in the EvoluTEM Starting grant. Traditional commercially available gas cells limit TEM imaging resolution and spectroscopy due to significant electron scattering. The EvoluTEM project has demonstrated a proof of principle cell design which reduces the electron scattering and hence provides opportunities for TEM experiments with greatly improved imaging of atomic structure and spectral analysis of local changes in oxidation state or elemental distribution. This research project will scale up the gas cell fabrication process, validating its performance in key applications and ensuring its compatibility with commercial TEM in-situ holder systems. The overall aim of this project is to provide the wider scientific and industrial TEM community with environmental cells that provide a step change in the performance of their existing in-situ technology. This will be vital for improved understanding of nanomaterials and catalysts under relevant environmental conditions, thereby accelerating the development of improved materials for applications such as sustainable energy generation, healthcare and new communication technologies.

Keywords: transmission electron microscopy,gas cell,in situ
MICROBOTS – Unravel the power of MICRObial metaBOliTeS to prevent graft versus host disease and cure leukemia relapse (MICROBOTS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1999901.0
EU funding (EUR): 1999901.0
Participants: 1
Project status: SIGNED

Allogeneic stem cell transplantation (allo-SCT) is the most common cellular immunotherapy for hematologic malignancies, but beneficial outcomes are limited by severe morbidity and mortality by graft-vs.-host disease (GVHD) and by relapse as a consequence of insufficient antitumor immune response (graft-vs-leukemia, GVL). In allo-SCT patients, a diverse gut microbiome is associated with beneficial clinical outcomes and fecal microbiota transplantation (FMT) emerges as a promising therapeutic option for acute gastrointestinal GVHD patients. Yet, how the gut and tissue-associated microbiome governs immune function and tissue homeostasis remains poorly understood. We identified microbial signatures - i.e., configurations of microbial communities and their associated immune-modulatory metabolites - in allo-SCT patients that (i) favourably associate with clinical outcomes, (ii) can engage an Interferon (IFN)-I inducing pathway to induce tissue regeneration, and (iii) protect mice from immune-mediated tissue damage. We therefore hypothesize that gut and tissue-associated microbial consortia and their immune-modulatory metabolites serve as a game changer for allo-SCT. “MICROBOTS” will test this by (i) providing a thorough characterization of microbiome/metabolome-host interaction at the epithelial interface in allo-SCT patients with or without GVHD, relapse and undergoing FMT and (ii) evaluating the functional impact of identified microbial signatures in advanced preclinical models of GVL and GVHD. These novel insights will provide a template for the design of a Precision FMT approach with defined microbial-metabolite cocktails aimed to achieve robust and durable antitumor responses in allo-SCT patients as well as to improve tissue regeneration and minimize immune-mediated side effects (GVHD). This may induce a paradigm-shift in clinical allo-SCT protocols and potentially other T cell transfer therapies (CAR/TCR T cells) in cancer treatment as a whole.

Keywords: allogeneic stem cell transplantation,cancer immunology,cancer immunotherapy,microbiome
Advancing Sampling and screening of Extremophile Microorganisms for biodiscovery of Bioactive Compounds from Volcanic, Desert, and Polar Ecosystems (XTREMOLIFE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Netherlands,Norway,Portugal,Spain,France
Call: Targeting aquatic extremophiles for sourcing novel enzymes, drugs, metabolites and chemicals (HORIZON-CL6-2024-CIRCBIO-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4500000.0
EU funding (EUR): 4500000.0
Participants: 12
Project status: SIGNED

XTREMOLIFE will accelerate the bioprospection & biodiscovery of novel extremophile microorganisms. XTREMOLIFE uniqueness is advancing next-generation sampling technologies tailored for extreme conditions: [1] Enhanced Ferrybox for boats (self-operating), [2] novel XTREMOsensor for hand-held use, and [3] automated microscopic imagery identification. In addition, we explore (a large) biodiversity from 3 extremophilic ecosystems by bioprospecting across 5 regions (Route 1), and 5 untapped culture collections (Route 2). We will join those two routes by identifying promising extremophilic microorganisms, produced metabolites, elucidating their bioactivity and structure, optimizing their cultivation, and guaranteeing a baseline pathway towards full exploitation. We will focus on microalgae, cyanobacteria, and their associated microbiome, with a particular interest in bacteria and fungi. The culture collections NORCCA (Norway), ACUF (Italy), BEA (Spain), LEGE-CC (Portugal), TII (Abu Dhabi/UAE) will be prospected. In parallel, we will assess the microbiome and plan sampling from 5 locations: [1] Antarctic, [2] Volcanic aquatic environments in Canary Island, [3]Azores, [4]Mexico, and [5] Abu Dhabi: focusing on hypersaline and extremely hot springs. We will assess the complexity of extremophilic ecology resorting to physical, chemical and biological data gathered. The chemical prospection will cover bioassays in the human, fish and plant health fields. Bioactive compounds will be isolated, and their structure fully characterized. Together, the consortium will select up to 7 different microbial compounds of interest-producing strains to be cultivated at lab scale, followed by a scale up to TRL 5 (feeding an Exploitation Roadmap). Finally, XTREMOLIFE will cover the legal framework of sampling, preserving and exploiting genetic material. The pathway towards full industrial exploitation (5-10 years after the project) in the various markets of applications will be characterized.

Keywords: extremophiles,sampling innovations,bioprospecting and biodiscovery,microalgae and cyanobacteria,bioactivity,novel bioactive metabolites,pilot production