Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microfluidic Approaches for High-Throughput Fungicide Screening and Sensitivity Testing (MAHT-FunSST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-24
End date: 2021-04-23
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Fungicide development and screening is stuck in an innovation gap, in which it incurs staggering expenses and takes many years to get a fungicide to market, furthermore, many pathogens develop resistance against fungicides which necessitates the sensitivity screening and recalled fungicides. The present proposal is conceptualized to bridge the gap for high throughput (HT) screening of fungicides effectively, by designing the novel lab-on-chip device. Specifically, we will assess (i) baseline sensitivity of fungicides against phyto-pathogenic fungi, (ii) response of fungi to different doses of fungicides, (iii) antifungal effects induced on fungal conidia, (iv) specific enzyme inhibition by fungicide. The fungicide screening lab-on-a-chip will address the large and currently unmet need to model fungicide screening device, regarding the spatial and mechanical cues important for conidia. The project will be based on the state-of-the-art technical expertise of ELVESYS in microfluidic chip design and fabrication and will fully integrate the Experienced Researcher’s (ER) strong expertise with agricultural plant pathology, molecular plant-microbe interactions and fungicides design and screening to develop a HT fungicide screening chip. Testing and validation of the product will be by perfusion using a set of candidate fungicides. The development of lab-on-a-chip technology will result in increasing the pre- and in-field HT screening of fungicides for their efficacy, optimal dosing and toxicity. The device will minimize the cost of fungicide development and screening, thus reducing the economic burden in the EU area as well as having large implications on improving the production of food globally. Through this opportunity the ER will be immersed in a richly entrepreneurial environment at ELVESYS and exposed to marketing concepts. Together, these experiences will provide the ER with the optimal environment to become a leader in next generation tools for fungicide screening.

Keywords: plant pathology,fungicide discovery and design,potato diseases,fungicide screening,fungicide resistance and sensitivity,microfluidics,lab on a chip,molecular microbe plant interaction
Non-Invasive Quantitative Magnetic Resonance for Obese Children – the Paediatric LiverMultiScan Test (Paediatric LMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As for adults, chronic liver disease is children is a major, rapidly growing health problem. The main causal factor is obesity, leading to fatty liver disease and non-alcoholic steatohepatitis. Inadequately treated children with liver disease will impose a disproportionate life-long burden on a nation’s healthcare system. In the EU, one third of adolescents is overweight/obese. Current techniques to diagnose and monitor liver disease in children are poor, insensitive or invasive. Liver biopsy is painful, costly, and samples only a tiny fraction of the liver. Perspectum Diagnostics is a University of Oxford spin-out founded by world-leading clinical and engineering experts in MRI. They have developed a quick, non-invasive MRI test that measures accurately the main features of liver pathology. Clinical trials in adults show excellent diagnostic performance and reproducibility. Perspectum’s first product, LiverMultiScan (LMS), is CE-marked for diagnosis of adult liver disease. We propose substantial modification of LMS for liver disease in children/adolescents. This requires adaptation and optimization of the methods in LMS, not least definition of thresholds and grading of disease, and analysis/presentation of results. A multicentre clinical trial is needed to obtain solid clinical evidence of diagnostic efficacy and cost-effectiveness of Paediatric LMS. We will develop a study design with a clinical trials unit; establish a network of EU clinical sites; ensure recruitment and technical feasibility at each site; cost the clinical study; establish economic viability; obtain more precise estimates of market size and growth rates, as well as the economic benefit to users. Paediatric LMS can become the standard test for assessing chronic liver disease in children, presenting not only a huge economic opportunity, but also the chance to greatly improve liver health in EU children. We will deliver a business plan for a subsequent phase 2 application.

Keywords: childhood obesity,chronic liver disease in children,steatohepatitis,diagnosis,magnetic resonance imaging,biopsy,prognosis,therapy
Promotion and support to the implementation of the energy labelling for Space, Combi Heaters and Water Heaters with a focus on the “Package label” (LabelPack Aplus)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Austria,Italy,Italy,Italy,Germany,Belgium,France,United Kingdom,Portugal
Call: Removing market barriers to the uptake of efficient heating and cooling solutions (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-03-01
End date: 2018-07-31
Duration (months): 41.0
Total project cost (EUR): 1385797.5
EU funding (EUR): 1385797.5
Participants: 13
Project status: CLOSED

The ‘Label Pack A+’ project aims at supporting the implementation of the energy labelling of heating appliances while boosting its impact, the focus being on the “package label” and its potential to push for the uptake or renewable technologies, in particular solar thermal, in combination with more efficient conventional technologies. The project will address one of the main challenges related to this particular energy labelling process in relation to other Energy-related Products : the issuing of the package label by installers. This challenge involves the preparation of the industry, retailers and installers to this process, including the communication to the final consumer. Therefore, the main objectives of the project are to: - Provide guidelines, as well as standardized answers to clarify the responsibility of each actor in the supply chain. These activities will, in particular, focus on installers and SMEs, who might be facing specific implementation challenges; -> Facilitate the exchange of product fiches and product related information on the format of equipment’s databases, available to all the actors in the energy labelling process; -> Apply the energy labelling calculation methodology and make it available to all the actors in the supply chain in the form of a user-friendly online calculation tool; -> Develop and provide industry specific training material, especially focusing on the responsibilities’ and roles of installers in the energy labelling process; -> Provide tailor-made information for end consumers, which will either be directly accessible by them, or used by dealers to explain the significance and added value of the “package label”; -> Provide consolidated expertise on the energy labelling process to the Commission and national authorities, based on the experiences gathered on the pilot implementation in the participating countries.

Keywords: solar,heating,energy,labeling,package label,industry,installer,consumer,prodcut fiche,calculation,renewable
Membrane Potential and Stem Cell Potency in Normal and Malignant Tissues (MPSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The studies proposed in the current application seek to answer a critical question hindering progress in the early detection and treatment of cancer: How is normal differentiation and lineage commitment disrupted in the earliest stages of cancer development? As a first step to answer this question we have generated a multi-organ mouse cancer and lineage tracing model by recombining conditional oncogene, tumour suppressor gene and lineage tracing alleles in cells expressing Cre-recombinase from the Promin1 locus: Promin1 marks stem and progenitor cells in several organs. Focusing on the gastric mucosa we showed that this tissue is regenerated by normal Promin1 stem cells and forms gastric cancer when Kras and Tp53 mutations are introduced into these cells. Remarkably, comparison of the transcriptomes of normal and malignant Promin1+ gastric stem cells revealed a selective silencing of ion channels and solute carriers in the malignant stem population. One of these genes, Nalcn, encodes the ion channel responsible for the resting membrane potential of cells. Here, I will test the hypothesis that ion-channel regulated membrane potential dictates normal and gastric cancer stem cell differentiation capacity. To do this I will employ our newly developed conditional allele of Nalcn to alter membrane potential of normal and malignant gastric stem cells in vitro and in vivo. The effects of Nalcn modulation in gastric stem cells will be evaluated with developmental, histological, transcriptomic, ex vivo stem cell and electrophysiological studies. Specific Aim 1 focuses on the expression and impact of membrane potential in normal stem cells while specific Aim 2 probes the role of Nalcn expression on tumour formation. The results of these studies will contribute fundamental knowledge on our understanding of the role of membrane potential on stem cell potency in normal and malignant tissues and may provide a new therapeutic target for cancer treatment.

Keywords: membrane potential,mouse models
Advanced integrated supervisory and wind turbine control for optimal operation of large Wind Power Plants (TotalControl)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Norway,Sweden,Norway,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2018-01-01
End date: 2022-05-31
Duration (months): 53.0
Total project cost (EUR): 4876482.5
EU funding (EUR): 4876482.5
Participants: 13
Project status: CLOSED

Cost of energy (COE) is the most important single factor in deployment of renewables in the energy system. Reduction of COE is, among other things, directly related to operational control of Wind Power Plants (WPP) as a whole and the individual wind turbines (WT) within them. In the Total Control project the COE reduction will be pursued by developing and validating advanced integrated WPP/WT control schemes, where all essential interactions between the WPP WT’s are accounted for including both production and load aspects. Optimal WPP control is traditionally formulated as a one-parameter optimization problem focusing on the WPP production only. However, ultimately the optimal WPP performance should result from a multi objective optimization problem, where the optimal economic performance of a WPP is pursued over the WPP life time, conditioned on external grid demands. This is what Total Control is about. The suggested integrated WPP/WT control approach seeks the optimal economical WPP revenue – i.e. the optimal economic balance between WPP power production and WPP operational costs. This is done by developing hierarchically coupled WPP and WT control schemes conditioned on a set of superior grid operator demands. In the WPP control design phase information is only fed from the WPP controller to the individual WT controllers, whereas in on-line operational control available WT and WPP flow field information will be assimilated into the WPP control for optimal system performance. Furthermore, the WPP controller will also make use of current market information (e.g. energy price, demand for ancillary services etc.) as well as information about the state of individual turbines (e.g. current operational state, maintenance requirements and component lifetime consumption) to allow COE objectives to be optimised dynamically.

Keywords: wind power plant,wind farm,wind turbine,levelised cost of energy,lcoe,control strategies,oandm cost,ancillary services,optimal control
Innovation pathways, strategies and policies for the Low-Carbon Transition in Europe (INNOPATHS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Germany,Germany,Switzerland,Finland,Poland,Greece,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Pathways towards the decarbonisation and resilience of the European economy in the timeframe 2030-2050 and beyond (H2020-SC5-2016-OneStageB, 2016)
Start date: 2016-12-01
End date: 2021-07-31
Duration (months): 56.0
Total project cost (EUR): 6345578.75
EU funding (EUR): 5996716.25
Participants: 15
Project status: CLOSED

The Paris Agreement substantially increased the need for countries and regions to understand the full economic, social and environmental implications of the deep decarbonisation to which the global community is now committed. The EU has long had decarbonisation ambitions, but there remains considerable uncertainty as to precisely how these ambitions will be achieved, or what the impacts of such achievement will be on the EU economy and society more generally. INNOPATHS will resolve this uncertainty to the extent possible, will characterise and provide a quantification of the uncertainty which remains, and will describe in great detail a number of possible low-carbon pathways for the EU, together with the economic, social and environmental impacts to which they are likely to lead. These pathways will be co-designed with the aid of 23 stakeholders from different sectors who have already provided letters of support to INNOPATHS. INNOPATHS will suggest through this analysis how the benefits of these pathways, such as new industries, jobs and competitiveness, may be maximized, and how any negative impacts, such as those on low-income households, or on carbon-intensive sectors, may be mitigated. INNOPATHS will communicate its insights through the normal scientific channels, and make substantial contributions to the scientific literature, but will go well beyond this in terms of interactions with stakeholders, building on the co-design processes in the project to reach out to stakeholder networks of businesses, NGOs, local and national policy makers. INNOPATHS will create four innovative online tools to explain its pathways, technological transitions and policies, to different constituencies. Through these tools and other dissemination and communication mechanisms, INNOPATHS will have a substantial impact on the climate and energy policy debates up to and beyond 2020, increasing the probability that decisions in this area will be taken in an informed and cost-effective way

Keywords: technology assessment,integrated assessment and energy system modelling,socio economic analysis of low carbon options,decision support tools
An assessment and treatment tool for visual dysfunctions in children (EyeWideVision)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Spain
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

It is estimated that approximately 30-50% of the general population in children (5-15 years old) suffer from some visual functional dysfunctions, and 10% of them have a serious impairment that affects their daily life. Nevertheless, once detected such dysfunctions can be improved in 95-100% of the cases through training or therapy, but only 2% of these patients are being treated. To solve this problem, we have developed WIVI. WIVI is an assessment and treatment tool for visual dysfunctions detection based on immersive 3D techniques, which examines in a multiparametric way the visual system in its full extension, i.e., it provides a complete cognitive, neural and physic phases assessment. WIVI reduces the standard treatment period from 6 months to 2,5 months, and each session duration is reduced by 75%. Price wise, WIVI allows to save between 58% up to 85% of the total cost of current alternatives. Our product has been tested on 15 children between 5 and 17 years old and on 40 adults in the age range 18 to 70, reaching 95% of accuracy in measurements. The global clinical devices for the visual function assessment market is anticipated to grow from an estimated USD 29,171 million in 2014 to USD 42,685 million in 2020 at a CAGR of 6.5% during the forecast period. The overall objective of the WIVI business project is to establish WIVI as a worldwide standard in visual dysfunction assessment and treatment, supporting it in real-time high detection rates, cheaper and faster clinical practices.

Keywords: visual dysfunctions,assessment,treatment,autonomous procedures,children
Highly Efficient Photoemitters for Light-Emitting Diodes Based on Intramolecular Rotation (ROLEDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-07-01
End date: 2018-12-31
Duration (months): 18.0
Total project cost (EUR): 149115.0
EU funding (EUR): 149115.0
Participants: 1
Project status: CLOSED

We have discovered a new class of photo- and electroluminescent complexes which are suitable for incorporation into organic light emitting diodes (OLEDs) and which give up to 100% internal quantum yield. The new compounds are particularly suitable for the fabrication of OLEDs via cheap solution-processing techniques and have so far reached 27% external quantum efficiency, a record for any solution-processed device. The new complexes have a linear, rotationally flexible structure, and it is this rotation that allows 100% of the excitation energy to be harvested, by a new emission mechanism (“rotationally accessed spin-state inversion”, RASI). OLEDs are widely used as flat-screen displays (TVs, smartphones), a multi-billion dollar market worldwide. The industry-leading emitters are based on complexes of iridium, one of the rarest elements on earth. Our emitters are compounds of copper, silver and gold, suitable as “slot-in” replacements of iridium. IPR is protected by two UK and one PCT World patent applications. The key discovery is that in certain types of coordination complexes based on carbene ligands the excited singlet state sinks below the excited triplet state during molecular rotation. To our knowledge this is the first realization of "spin-state inverted" materials, until now discussed only as a theoretical concept. The result is efficient, very fast light harvesting with highly desirable short (sub-microsecond) excitation lifetimes, leading to high display brightness (in prototypes 20 times brighter than a HD TV screen), with potential lighting applications.

Keywords: light emitting diodes,display screens,energy harvesting,gold complexes,silver complexes,copper complexes,carbene ligands,luminescence
Disorder and Order in the Conversion Mechanism of Metal Oxides in Lithium-ion Batteries (DisorMetox)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Binary transition metal oxides (MxOy) have been studied as anode electrode materials for Li-ion batteries (LIBs) for many years. Defined as a class of conversion material, these MxOy undergo multi-electron reactions (per formula unit) leading to highly desirable capacities and have drawn considerable attention. Over the last decade, most of the earlier efforts were devoted to material nanostructuring, which has proven effective to enhance the overall material performance. However, critical issues such as the large hysteresis and low Coulombic efficiency remain key obstacles hindering the commercial application of MxOy. To overcome these obstacles requires a good understanding of the reaction fundamentals, which has yet been achieved due to the challenges involved in the characterisation of these MxOy. Previous mechanistic studies found that these MxOy undergo a chemical pulverisation leading to coexistence of multiple nanoscopic/defected or even amorphous/disordered phases. In view of these complex structural features and high heterogeneity of the system, it is difficult for a quantitative and accurate phase identification and structural characterization using conventional analytical approaches. This proposal will, therefore, develop a novel approach based on reverse Monte Carlo (RMC) method using the X-ray/neutron total scattering data, to study the reaction thermodynamics of these MxOy in the LIBs with emphasis on the investigation of the (apparent) structural disorder and (hidden) order present in the system. The proposed project will target a series of iron and manganese oxides as model compounds because they are the most studied conversion MxOy and their stable phases manifest considerable compositional/crystallographic variations constituting a large library of materials for a systematic study. The project will be hosted by Prof. Andrew Goodwin (Oxford Chemistry), an expert in studying complex structures of functional materials and their unusual properties.

Keywords: transition metal oxides,lithium ion batteries,reaction mechanism,total scattering,rmc method