Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FAST-PSAT. An innovative solution for building small satellites with a modularity design by using plastic polymers with fast prototyping 3D techniques: a “Lego® brick” concept (FAST-PSAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Italy
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FAST-PSAT (FAST Plastic SATellite) is a project created by PicoSaTs, an Innovative Start-up company. The aim is define a razor-and-blade business model to launch on the market a new solution for building small satellites by using a promising plastic polymer and 3-D manufacturing technique, with a modularity design, a “Lego® brick” concept. This solution would significantly improve access to space to many players, particularly small companies and research institutes, and it would solve technical, operational, social and economic issues that characterize the design phase and development process of current customised small satellite production, both in civilian and military applications. Over the last decade more than one hundred small satellites have been launched; this number will tremendously increase in the next future, with over 400 small satellites already in 2016. FAST-PSAT aims at providing the means to get independency in satellite mechanical manufacturing and to grant accessibility and adaptability of space industry, in the light of a remarkable interest in small space programs, both in the scientific and industrial field. The availability of a modular, non-metallic bus that can host a variety of payloads, primarily devoted to Earth observations and Remote Sensing, provides EU-wide means for a low-cost access to space, and meets the requirements for coping with the global challenges: effective observations and communications from space for monitoring natural hazards, agricultural aspects and security ones at low-cost and with low environmental impact upon re-entry. The modularity concept can be even extended to larger structures to simplify and standardise satellite production and further enhance the economies of scale. With FAST-PSAT Europe can become the worldwide leader of in space usage of plastic materials manufactured using fast prototyping techniques.

Keywords: small satellites,polymers,3 d printing,cubesat,lego bricks
ENvelope meSh aNd digitAl framework for building REnovation (ENSNARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Innovation actions
Countries involved: Italy,Germany,Germany,Italy,Estonia,Spain,Spain,Spain,Ireland,Italy,Italy,Italy,Spain,North Macedonia,Bulgaria,Finland,Hungary,France,Netherlands,Netherlands,Denmark,United Kingdom
Call: Industrialisation of building envelope kits for the renovation market (IA) (H2020-NMBP-ST-IND-2020-singlestage, 2020)
Start date: 2021-01-01
End date: 2025-01-31
Duration (months): 49.0
Total project cost (EUR): 9995244.68
EU funding (EUR): 7993653.04
Participants: 24
Project status: SIGNED

ENSNARE’s main objective is to boost the implementation of renovation packages through (1) the digitalisation of the entire process by means of a digital platform and (2) the development of an industrialised envelope mesh enabling fast assembly and interconnection of passive and multifunctional building components. The methodology and tools provided will facilitate the necessary market uptake of novel and highly efficient solutions for nZEB, accelerating the current retrofitting rate and supporting the transformation of the European building stock into a highly efficient and technologically advanced built environment. Within a comprehensive systemic approach, the project will target the development of modular adaptable components to be integrated within the system (rather than marketed as standalone products that increase the cost and complexity of the system), including an active window for ventilation and heat recovery, solar harvesting devices (thermal collectors, PV and hybrid panels with advanced technologies such as roll-bonding), heat pumps and energy batteries for load shifting. The digital platform will comprise a set of digital tools supporting and accelerating all stages for a more efficient renovation process: automated data acquisition, LCA/LCC analysis and decision support, digital BIM model building and computer-assisted manufacturing (CAM), and a smart building management system (sBMS) for optimised operation and maintenance. All these tools are linked to a digital model, which increases in complexity and interaction potentialities as the project develops. At completion, the model becomes a Digital Twin of the renovated building allowing real-time monitorization, simulation and optimised operation of all building components. The ENSNARE solution will be validated through three pilot renovation projects covering Nordic, Continental and Mediterranean climates, and three virtual demonstration buildings aimed at upscaling the development of the solution.

Keywords: envelope,building,energy,zero energy building,solar,solar collector,bems,digital twin,industrialization
Novel DNA adductomics methodological developments for research in colon cancer (Adductomics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Covalent modCovalent modification of DNA by exogenous genotoxic molecules can translate into gene alteration, possibly inducing carcinogenesis. The analysis of DNA modifications, referred to as DNA-adducts, is fundamental for assessing the mechanism of action of genotoxic molecules. Nowadays, high resolution mass spectrometry (HRMS) is one of the most promising technique for DNA-adduct identification. Despite DNA adductomics by HRMS is highly promising, it is a new born field, presenting several analytical challenges and requiring the development of sample preparation protocols, chromatographic and mass spectrometric methods, and identification approaches. So far the majority of DNA adductomics studies were done in vitro or in animals with few studies in humans. Colorectal cancer (CRC) is considered to be highly affected by exogenous genotoxicants. Smoking, consumption of alcohol, and meat intake only explain a minor part of sporadic CRC. The mechanism of DNA modification leading to CRC has not yet been elucidated but should provide new clues about causative factors. Therefore, a DNA adductomics approach will be used in this project. Hybrid ion mobility - quadrupole - time-of-flight HRMS instrumentation will be used to develop the analytical procedures using resected colon and colon biopsies as well as urine from subjects affected by CRC or familial adenomatous polyposis (FAP), the last showing high adduct levels and very high CRC risk. High levels of DNA-adducts in FAP will increase chances of adduct identification. Urine will be used to identify DNA-adduct excretion products. The developed methods will then be used in a case-control human study with the aim of finding a correlation between specific DNA-adduct formation or specific excretion products and CRC, possibly identifying novel cancer risk biomarkers. Expanding the knowledge on DNA-adducts related to CRC could provide new opportunities for the design of more effective intervention and prevention approaches.

Keywords: adductomics,high resolution mass spectrometry,method development,metabolomics,analytical chemistry,toxicology
An ARTery of EMPIRE. Conquest, Commerce, Crisis, Culture and the Panamanian Junction (1513-1671) (ArtEmpire)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Spain,Italy,Germany,Colombia
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 1998875.0
EU funding (EUR): 1264528.64
Participants: 4
Project status: CLOSED

European incursions onto the narrow isthmian pass that divided and connected the Atlantic and Pacific oceans made it a strategic node of the Spanish Empire and a crucial site for early modern globalization. On the front lines of the convergence of four continents, Old Panama offers an unusual opportunity for examining the diverse, often asymmetrical impacts of cultural and commercial contacts. The role of Italian, Portuguese, British, Dutch, and French interests in the area, as well as an influx of African slaves and Asian merchandise, have left a unique material legacy that requires an integrated, interdisciplinary approach to its varied sources. Bones, teeth and artifacts on this artery of Empire offer the possibility of new insights into the cultural and biological impact of early globalization. They also invite an interdisciplinary approach to different groups’ tactics for survival, including possible dietary changes, and the pursuit of profit. Such strategies may have led the diverse peoples inhabiting this junction, from indigenous allies to African and Asian bandits to European corsairs, to develop and to favor local production and Pacific trade networks at the expense of commerce with the metropolis. This project applies historical, archaeological and archaeometric methodologies to evidence of encounters between peoples and goods from Europe, America, Africa and Asia that took place on the Isthmus of Panama during the sixteenth and seventeenth centuries. Forging an interdisciplinary approach to early globalization, it challenges both Euro-centric and Hispano-phobic interpretations of the impact of the conquest of America, traditionally seen as a demographic catastrophe that reached its nadir in the so-called seventeenth-century crisis. Rather than applying quantitative methods to incomplete source material, researchers will adopt a contextualized, inter-disciplinary, qualitative approach to diverse agents involved in cultural and commercial exchange.

Keywords: conquest,commerce,cultural exchange,global history,globalization
Dexterous ROV: effective dexterous ROV operations in presence of communication latencies. (DexROV)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Switzerland,Belgium,France,Netherlands
Call: Delivering the sub-sea technologies for new services at sea (H2020-BG-2014-2, 2014)
Start date: 2015-03-01
End date: 2018-08-31
Duration (months): 42.0
Total project cost (EUR): 5336006.25
EU funding (EUR): 4631182.5
Participants: 9
Project status: CLOSED

Underwater operations (e.g. oil industry) are demanding and costly activities for which ROV based setups are often deployed in addition to deep divers – contributing to operations risks and costs cutting. However the operation of a ROV requires significant off-shore dedicated manpower – such a setup typically requires a crew consisting of: (1) an intendant, (2) an operator, and (3) a navigator. This is a baseline, and extra staffing is often provisioned. Furthermore, customers representatives often wish to be physically present at the off-shore location in order to advise on, or to observe the course of the operations. Associated costs are high. In order to reduce the burden of operations, DexROV will work out more cost effective and time efficient ROV operations, where manned support is in a large extent delocalized onshore (i.e. from a ROV control center), possibly at a large distance from the actual operations - thus with latencies in the communication. As a main strategy to mitigate them, DexROV will develop a real time simulation environment to accommodate operators’ requests on the onshore side with no delays. The simulated environment will exploit cm accuracy 3D models of the environment built online by the ROV, using data acquired with underwater sensors (3D sonar and vision based). A dedicated cognitive engine will analyse user’s control requests as done in the simulated environment, and will turn them into primitives that the ROV can execute autonomously in the real environment, despite the communication latencies. Effective user interfaces will be developed for dexterous manipulation, including a double advanced arm and hand force feedback exoskeleton. The ROV will be equipped with a pair of new force sensing capable manipulators and dexterous end-effectors: they will be integrated within a modular skid. The outcomes of the project will be integrated and evaluated in a series of tests and evaluation campaigns, culminating with a realistic offshore trial.

Keywords: long range teleoperation,communication latencies,force feedback,real time simulation,machine learning,3d perception,3d modelling,autonomy,dexterous manipulation
European Marine Biological Research Infrastructure Cluster to promote the Blue Bioeconomy (EMBRIC)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Israel,Germany,Germany,Germany,Italy,Italy,Germany,Norway,Norway,Belgium,Greece,France,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Implementation and operation of cross-cutting services and solutions for clusters of ESFRI and other relevant research infrastructure initiatives (H2020-INFRADEV-1-2014-1, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 9041611.0
EU funding (EUR): 9041611.0
Participants: 36
Project status: CLOSED

Marine (blue) biotechnology is the key to unlocking the huge economic potential of the unique biodiversity of marine organisms. This potential remains largely underexploited due to lack of connectivity between research services, practical and cultural difficulties in connecting science with industry, and high fragmentation of regional research, development and innovation (RDI) policies. To overcome these barriers, EMBRIC (European Marine Biological Resource Infrastructure Cluster) will link biological and social science research infrastructures (EMBRC, MIRRI, EU-OPENSCREEN, ELIXIR, AQUAEXCEL, RISIS) and will build inter-connectivity along three dimensions: science, industry and regions. The objectives of EMBRIC are to: (1) develop integrated workflows of high quality services for access to biological, analytical and data resources, and deploy common underpinning technologies and practices; (2) strengthen the connection of science with industry by engaging companies and by federating technology transfer (TT) services; (3) defragment RDI policies and involve maritime regions with the construction of EMBRIC. Acceleration of the pace of scientific discovery and innovation from marine bioresources will be achieved through: (i) establishment of multidisciplinary service-oriented technological workflows; (ii) joint development activities focusing on bioprospection for novel marine natural products, and marker-assisted selection in aquaculture; (iii) training and knowledge transfer; (iv) pilot transnational access to cluster facilities and services. EMBRIC will also connect TT officers from contrasted maritime regions to promote greater cohesion in TT practices. It will engage with policy-makers with the aim of consolidating a perennial pan-European virtual infrastructure cluster rooted in the maritime regions of Europe and underpinning the blue bioeconomy.

Keywords: marine bioresources biotechnology technology transfer blue innovation access integration bioproducts
Climate Exposure Tool for Financial Risk Analysis (CLIMEX)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Switzerland,France
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-05-01
End date: 2020-10-31
Duration (months): 18.0
Total project cost (EUR): 99750.0
EU funding (EUR): 99750.0
Participants: 3
Project status: CLOSED

CLIMEX will bring to the market an innovative commercial product based on the research output of the FET research Project DOLFINS, i.e. the “Climate-Finance Stress-testing”. The innovation will narrow the gap between our prior top level research and the market. By delivering a B2B commercial tool for financial risk managers, CLIMEX will allow them to price climate risks in their portfolio management strategies, thus filling in an existing gap on the market. In particular, our innovation will provide detailed quantitative information about the exposure to climate risks of individual firms and financial institutions’ portfolios, thus allowing them to improve their business and environmental performance. To achieve this goal, CLIMEX designs a 12-months Commercialization Roadmap that pursues a patenting and a start-up strategy and a commercialization strategy, and delivers a website and Software as a Service demo, together with targeted dissemination events with key private and public finance stakeholders with whom the CLIMEX consortium has already engaged in a business dialogue. CLIMEX’s disruptive positioning on the market is achieved by combining cutting-edge scientific competence across three domains in which the CLIMEX members are international leaders, (i.e. models of risk and contract valuation in financial networks, environmental economics, Software as a Service demos) and their knowledge and know-how when it comes to implement the methods on actual clients’ portfolios. The consortium will have access to professional advise on technology transfer via a dedicated organization at the coordinator node, as well as support from experienced entrepreneurs in the field of fintech.

Keywords: portfolio management,financial risk analysis,climate risk,financial performance,climate finance stress testing,climate risk exposure,dolfins,software as a service
HeartWatch - contactless patient vital signs monitoring (HeartWatch)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There are over 200m people globally in need of Long term care who are in receipt of some form of government aid. There are 2 main problems faced in adequately providing this care: There are not enough workers in the industry to cover the demand – only 47% coverage currently; and current Medical tools are only good for short term monitoring, these are not automated and most are invasive. Contactless monitoring of health and physical conditions. Can detect symptoms of serious conditions such as heart attack and stroke before they actually happen. Using off-the-shelf digital cameras with resolutions above 2MP, HeartWatch’s facial recognition software can measure cardiac signal with over 97.5% accuracy and breathing signal with over 98% accuracy by detecting minor colour changes in the skin on a patient’s face. These can be used to detect Atrial Fibrillation with a 96% accuracy level. This helps solve both the problem of insufficient workforce and the need for a fully automated, non-invasive system. Total addressable market for Long Term Care in EU-15+Switzerland: $221B in year 2015 +4.1% CAGR -> $405B by year 2030. In the EU-15+Switzerland, there are 3.28m people in 2015 needing in-patient long-term care, and 7.12m at home. In whole of Europe 4.2m & 8m respectively. The business model is B2B direct sales of cameras and monthly subscription to nursing homes and long term care facilities, will then partner with distributors for scaling up. B2C sales through distributors of cameras and monthly subscription for home use. This is supplemented by a monthly subscription based model, accessing the monitoring and dashboard configurations and data insights for customers.

Keywords: ageing,vital signs,facial recognition,cardiac,breathing
Unconventional NMDAR signaling theory for Fragile X Syndrome (METAFRAX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2024-05-22
Duration (months): 36.0
Total project cost (EUR): 244385.28
EU funding (EUR): 244385.28
Participants: 2
Project status: SIGNED

Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability (ID), and the leading known genetic cause of autism. This dominant phenotype represents a huge hindrance for clinicians in the treatment of FXS because the underlying neuronal deficits remain unknown. Individual neurons store information as we learn and acquire new information by modifying their connections with nearby neurons, a process called synaptic plasticity. This refers to activity-dependent long-term changes in synaptic strength but also synaptic structure, and is highly regulated by NMDA receptors (NMDAR). It has recently been proposed that NMDARs can signal in an unconventional manner. Our goal is to understand how unconventional NMDRs drive synaptic plasticity, and how this is dysregulated in the mouse model of FXS. For this, we will record electrical activity of the neurons and image synaptic structures during different forms of synaptic plasticity, and characterise metabotropic NMDAR signaling by functional genomic approaches. In summary, we will use a multi-disciplinary approach to unravel the mechanisms responsible for synaptic plasticity alteration in the mouse model for FXS and further our understanding of the neuronal processes underlying cognitive phenotypes of FXS. The outcomes of these experiments will not only offer hope to patients with FXS but will also further our understanding of the molecular basis of synaptic plasticity. If successful, this could serve as the basis for future molecular targets to promote cognitive recovery from ID, autism spectrum disorders and other diseases. The project is an excellent opportunity for the researcher to further develop her knowledge and to position her in unique multidisciplinary environment that will foster her career progression towards independence. The researcher’s experience acquired at MIT and during the outgoing phase at McGill will be extremely valuable for the host institution and the European research area.

Keywords: fragile x syndrome,nmda receptor,unconventional signaling pathway,metabotropic signaling,synaptic plasticity