Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Versatile Polypeptide-based Intranasal Drug Delivery Platform(s) to Tackle CNS Disorders. (POLYBRAINT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Nearly one in six of the world's population suffered from neurological disorders, this number is expected to keep growing. Many of those central nervous system (CNS) disorders do not have still an approved therapy, mainly due to one of the most challenging barriers, the blood-brain barrier (BBB). Only 2% of small-molecule drugs and ~0% of biologic drugs can reach the brain, thus stunting the development of treatment options. In POLYBRAINT we will explore the technical and commercial feasibility of an intranasal drug delivery platform (derived from ERC consolidator MyNano) to deliver biological agents to the brain for the treatment of CNS pathologies. After an adequate functionalization, our intranasally (i.n.) administered nanocarrier can reach the brain and diffuse through to specific areas of interest (i.e. hippocampus, olfactory bulb...). POLYBRAINT aims to confirm the transport, delivery, and controlled release of a functional biological agent, establish an intellectual property strategy, and assess the future commercialization feasibility of our innovative platform. Our i.n. platform has unique properties capable to overcome the main limitations of existing approaches and can revolutionize what has been achieved so far in the field, including greater versatility, higher loading capacity and controlled-sustained drug release after rationally design bioresponsive conjugation strategies among others. Additionally, our nanocarrier can be scaled at the industrial level and thus overcome a significant bottleneck of current nanocarrier-based therapeutics. Our platform offers a highly attractive business case, as biotechnology and pharmaceutical companies heavily invest in nanomedicine due to the need for novel drug delivery strategies that can cross challenging biological barriers such as the blood-brain barrier.
Detection of pedestrians and cyclist outside a line of sight (DeepSight)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The number of road accidents continue to increase dramatically each year. Cyclists and pedestrians, being a part of the daily traffic, keep challenging drivers thus making safety issues increasingly important. Furthermore, miniature electrical vehicles, paving their way through traffic and being in many cases unseen by drivers, put themselves in danger. Improving driving safety, being always a subject to technological efforts, is one of the most important challenges of the modern society. Continuously developing technologies offer a broad range of tools, capable to assist a driver in a decision making. Moreover, autonomous vehicles, nevertheless facing a broad range of challenges nowadays, will certainly sooner or later contribute to the endeavor. Optical camera solutions, LIDARs and high-frequency radars are already demonstrating exceptional assistance in driving safety by providing overlapping and complementary data. However, all existent safety systems require having an unperturbed line of sight to obstacles. This is a severe limitation, which cause those systems to overlook numerous dangerous events, including pedestrians, stepping on a road from behind a parked vehicle and many others. MHz and lower GHz frequencies are known to penetrate material bodies and diffract around obstacles - e.g. we have a Wi-Fi signal in office, nevertheless the router is placed behind a wall in a corridor. However, low frequency waves are never used in automotive applications owing to low range and angular resolutions they can grant, as it is commonly believed. While this statement is almost a ground truth in the field, it can be bypassed if a preliminary information on an object does exist. This includes and not limited to rotating bicycle wheels, human breath, and several others. Here we will develop a low-frequency radar for detecting cyclist and pedestrians with a resolution, sufficient to ensure a road safety and assisting drivers to make right decisions.
City buzz: Quantity, quality, and variety implications of the urban environment (CITYBUZZ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 2491628.0
EU funding (EUR): 2491628.0
Participants: 1
Project status: SIGNED

This research project aims to understand the changing landscape of cities. These are cities where face-to-face interactions happen less around office water coolers and more on the streets; where individuals not only produce differently by location but also have heterogeneous consumption; and where, beyond the adoption of working from home, the transformation of work involves a reorganisation of firms' establishments and hierarchies across locations. To capture face-to-face interactions accurately, we use anonymised cellphone records to identify spatial and temporal overlaps among users who also have phone conversations. By combining location and call data, meaningful interactions are distinguished from passing strangers, while quantifying social connectivity and distinguishing between strong and weak ties. The project examines variations in quantity, quality, and diversity of face-to-face interactions across spatial contexts. It isolates the effects of the urban environment from personal characteristics by studying individual changes following shocks. The project also investigates consumption differences across locations. It uses anonymised credit card data to examine the quantity, quality, and variety of consumption venues, going beyond locally available venues to explore how individuals utilise them and accounting for endogenous amenities and location choices. We consider co-consumption evidence, residence, and job information to understand leisure interactions among neighbours, co-workers, and friends. Finally, we explore changes in the hierarchical organisation of firms across space. Using matched employer-employee data and a model of cities and hierarchies, we investigate how firms organise establishments and managerial hierarchies across locations. Moreover, we examine the relationship between systematic differences in firms' hierarchies across cities and workers' progression to explain the city-size earnings premium.

Keywords: cities agglomeration economies density urban form face to face interactions accessibility amenities hierarchies spatial data cellphone data matched employer employee data transaction data
Exploration of Unknown Environments for Digital Twins (explorer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2476718.0
EU funding (EUR): 2476718.0
Participants: 1
Project status: SIGNED

In the 'explorer' project, we will develop methods for automatically capturing and labelling video data in "open worlds". The ultimate goal is the great facilitation of the creation and maintenance of Digital Twins: Digital Twins are virtual 3D copies of complex scenes such as cities, factories, or construction sites. Not just a 3D reconstruction, they should capture the scene's semantics, i.e. the identity of each object and the scene's dynamics, i.e. how objects move. Because Digital Twins have the potential to be extremely useful for monitoring large complex sites and planning the development of these sites, their forecast market is huge, they remain mostly a concept because of important limitations of the current technology. Our methods will guide autonomous systems such as robotic platforms and UAVs through complex and unknown environments to capture visual data for creating and maintaining Digital Twins. This is extremely challenging as these systems will encounter objects without any prior knowledge about them and will have to collect sufficient data about them. To the best of our knowledge, this active and automatic capture in complex real environments is a new problem. It is however very important to solve it as this will relax the need for human expertise and time: Currently, capturing such data is done manually only by researchers and requires strong understanding of what the learning algorithms require. To tackle the complexity of this problem, our approach is inspired by techniques from Artificial Intelligence applied to the exploration of extremely large trees. This approach will allow us to bring the perception part and the planning part of the problem together under the same optimization framework, to formalize it and solve it efficiently. To evaluate our developments, we will create a dataset of annotated video sequences from working sites, which we will share with the community.
VoluFaTE: Volumetric programming of cells to control the fate and function of engineered tissues (VoluFaTE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-15
End date: 2026-09-14
Duration (months): 36.0
Total project cost (EUR): 296296.32
EU funding (EUR): 296296.32
Participants: 2
Project status: SIGNED

Engineering living tissues is expected to revolutionize pharmacological screenings, fundamental biological studies, cruelty-free meat production, and engineered organ replacements. Historically, the functional performance of the living cells within engineered tissues is controlled exclusively via chemical (e.g., growth factors or cell binding peptides) or mechanical (e.g., stiffness/stress relaxation) properties of the biomaterial. All these approaches are united in their shared grand limitation: the cell’s (in)ability and (in)sensitivity to any given signal. This imposes strict design constrictions and associates with donor variation, which has hindered clinical translation and commercial valorisation. In recent years, it has become known that cell volume dictates sensitivity and responsivity of cells to their microenvironmental cues. Indeed, pathophysiological microenvironments induce alterations in cell volume, which underpins the aetiology of numerous diseases. Although it is anticipated that controlling cellular volumes thus can program the behavior of engineered tissues, especially when implanted in diseased sites, currently no strategy to realize this in 3D tissues is available. This proposed VoluFaTE project aims to leverage a cutting-edge single-cell microgel technology to overcome this grand challenge by providing the world’s first platform to program cell volume in a scalable, widely-applicable, and translatable manner. Healing of cartilage defects is chosen as a model system.

Keywords: chondrocytes,cartilage biology,molecular crowding,cell volume,cell fate control enabling microtechnologies
Anionic Exchange Membrane water ELectrolysis for highLY efficIenTcy sustAinable, and clean Hydrogen production (AEMELIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: France,Spain,Norway,Italy,Belgium,United Kingdom
Call: Innovative electrolysis cells for hydrogen production (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2027-02-28
Duration (months): 38.0
Total project cost (EUR): 2764927.0
EU funding (EUR): 2764926.75
Participants: 11
Project status: SIGNED

AEMELIA accepts the challenge to design and prototype AEMEL that meets and surpasses Hydrogen Europe’s 2030 targets for performance, durability, safety and cost. AEMELIA proposes a clear path to reach high current-density (1.5 A cm-2) and low voltage (1.75 V). Energy-efficiency surpasses the 2030 target (46.9 kWh/kg, or 85% of maximum theoretical efficiency), to make 3 times more H2 with less energy compared to XY. LCOH also outshines 2030 targets at 2.5€/kgH2 (17% lower than 2030 target). The degradation rate meets the 2030 target, enabling a 10-year lifetime. These and other KPIs will be validated via the TRL4 prototype of a 5-cell stack at 100 cm² that will deliver 7.2 Nm3/day of H2 at a purity of 99.9% at 15 bar. The team will develop and test disruptive materials, such as fluorine-free ionomers ; thin, highly-conducting membranes ; PGM-free recombination catalysts ; and ionomer-free electrodes. These components are based on earth-abundant, safe materials. They would be fully scalable via existing manufacturing processes. They will be combined in innovate cell designs, taking into account novel flow-field design based on CFD models. Innovative operating conditions such as high operating temperature and pulsed current will increase energy-efficiency while reducing balance of plant (BoP) and will be tested in single cells, as will the use of impure water for improved LCA and cost. Lastly, disruptive methods for AI-based ionomer development and the measurement of the catalytically-active surface area of non-PGM catalysts will be developed. Performance, durability, LCA and cost KPIs will be shared with companies to convince them to invest in upscaling after the project. Partners have many success stories in developing disruptive electrochemical materials and systems and bringing them to market. AEMELIA’s market penetration in 2031 is expected to generate 527 M€ in revenues by 2036, and 1172 kt CO2/year avoided compared to steam methane reforming.

Keywords: hydrogen,anion exchange membrane,electrolysis,crm free catalyst,f free membrane,stack development,material informatics,cfd model,lca,electrochemical surface area,recombination catalyst,ptl
Model Reduction for Complex Systems with Exponential Nonlinearity via Geometric Singular Perturbation Theory (GSPTexp)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria,Denmark,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-02
End date: 2026-04-01
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 3
Project status: CLOSED

Important aspects of nonlinear complex systems like the Earth's climate, gene regulatory networks or the global telecommunication network can be modelled mathematically by systems of ordinary differential equations. However, the dynamics of such systems can rarely be understood by direct numerical simulation due to significant problems including high dimensionality, strong nonlinearity and processes occurring over a wide range of timescales. This leads to the necessity of model reduction, i.e. the identification of reliable methods for discarding unnecessary details to obtain a simpler 'reduced system', whilst preserving the salient dynamical features of the original system. Existing approaches to model reduction rely on a combination of methods which (i) exploit multi-scale structure in order to decompose the problem into lower dimensional subsystems, and (ii) reduce nonlinearity by replacing highly nonlinear terms by piecewise-smooth (PWS) approximations. Despite substantial progress in particular applications, a sound mathematical basis is often lacking and existing methodologies sometimes lead to qualitatively different results. This project addresses a number of limitations to existing model reduction techniques, by developing a mathematical formalism which we call "GSPTexp". We begin by building upon recent developments in Geometric Singular Perturbation Theory, with the aim to formalise recently identified connections between PWS systems and multi-scale systems with exponential nonlinearities. Via multiple novel adaptations of a geometric method known as blow-up, the GSPTexp formalism will be developed and used as a mathematically sound method for model reduction of (i) classical model problems from combustion and (ii) gene regulatory networks. Finally, in an ambitious interdisciplinary collaboration with systems biologists, we aim to couple GSPTexp with emerging techniques based on tropical geometry to study and simplify (iii) biochemical networks.

Keywords: geometric singular perturbation theory,multi scale systems,exponential nonlinearity,piecewise smooth systems,gene regulatory networks,systems biology,combustion theory
Exploration of the biosynthetic potential of the secondary metabolome of the newly identified fungal endophyte Cyanodermella asteris (CyanoAsterisMETAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-01-31
Duration (months): 25.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

In the proposed research I aim to explore the secondary metabolome of the newly identified fungal endophyte Cyanodermella asteris. In this regard, we have selected two in silico-predicted polyketide synthase gene clusters, which will be further examined. The selected gene clusters thereof are chosen for vector construction in Escherichia coli and subsequently the heterologous expression in fungal hosts (Aspergillus niger or Aspergillus nidulans) will be performed. Afterwards, the engineered expression strains will be examined in a combined effort applying mass spectrometry and nuclear magnetic resonance experiments to identify the newly produced compounds. Additional metabolomics-based tools and molecular networking will be employed. Moreover, the biosynthetic pathways of the isolated natural products of the respective gene clusters will be fully delineated.

Keywords: cyanodermella asteris,fungal endophytes,heterologous expression,natural products,biosynthesis
DanceMap: Innovation Pathways and Policies to Promote European Dance Heritage at Home and Abroad (DanceMap)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: Germany,Bulgaria,United Kingdom,North Macedonia,Israel,Croatia,Slovenia,Serbia,Belgium,Portugal
Call: Europe’s cultural heritage and arts – promoting our values at home and abroad (HORIZON-CL2-2024-HERITAGE-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3993973.67
EU funding (EUR): 3944966.79
Participants: 17
Project status: SIGNED

The heritage of 20th century dance in Europe is largely invisible and in real danger of being lost. Works that are no longer being performed – even from the recent past – are forgotten, their memory confined to small and fragmented communities of artists and practitioners. DanceMap proposes an ambitious strategy for safeguarding and promoting dance heritage. It is a map both in the geographical sense, showcasing examples of successful dance heritage initiatives all over Europe and making them accessible for a wider global public, and in the sense of a blueprint or roadmap towards effective and sustainable policy solutions at regional, national and European level. Combining excellence in research and extensive experience of delivering innovative dance heritage initiatives at the national level, the DanceMap consortium has developed an integrated, cross-sectoral approach that incorporates research, data science, artistic practice, outreach, advocacy and policymaking. The consortium is a 16-strong alliance of research centres, universities, archives, arts organisations and leading policy experts, who recognise that dance represents values which are central to the European project: It is a collaborative, non-logocentric, embodied practice that mirrors European conviviality and draws on marginal experiences and perspectives, which – along with connotations of femininity and queerness – have contributed to dance’s low status and lack of funding relative to other art forms. With this project, the consortium makes the case that European dance heritage is overlooked in its ability to build a contemporary image of the EU as a progressive, diverse and inclusive political entity. One of its aims is to ensure that dance is included in the common European data space for cultural heritage (ECCCH) as a use case for other embodied practices.

Keywords: culture,intangible heritage,arts,dance,humanities,digital,gender,european values,inclusion,well being,youth,sustainability,embodied knowledge,collaboration