Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CHAPAS-5: An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in ART-naive and Treatment-experienced Viraemic Children and Adolescents Living with HIV in Africa (CHAPAS-5)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: United Kingdom,Uganda,Mozambique,Zimbabwe,Netherlands,Italy
Call: Developing novel, innovative HIV therapeutics for reducing the disease burden of HIV in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 6587149.0
EU funding (EUR): 6587149.0
Participants: 10
Project status: SIGNED

The 2.5 million children and adolescents living with HIV (CALHIV), most residing in sub-Saharan Africa, have unacceptably high rates of late diagnosis, treatment failure and death, compared to their adult counterparts. CALHIV are a vulnerable group who have been left behind adults in testing new treatment options, different modes of ART delivery, novel diagnostics and adherence strategies. The CHAPAS-5 trial is a sustainable multi-country adaptive platform trial in Mozambique, Uganda and Zimbabwe, to assess novel treatment regimens in ART-naïve and treatment-experienced viraemic children aged 4 weeks to <20 years of age. CHAPAS-5 employs an innovative Personalised Randomised Controlled Trial (PRACTical) design, randomising participants between appropriate ART regimens based on their clinical status, ART history, genotypic resistance and drug availability by weight band. The trial's primary outcome is: alive with viral load <400 c/mL at 48 weeks. CHAPAS-5 will evaluate novel oral and first generation long-acting injectable (LAI) treatment regimens and, subsequently, through its adaptive design, second-generation promising long-acting therapeutics. Nested pharmacokinetics will evaluate dosing for children, as needed. Social science, health economics and capacity strengthening are fully integrated through the project. Workpackages will explore options for community-delivery of LAIs, and employment of diagnostics, including POC CD4, near-POC viral load and resistance tests. Community groups and young people will be involved in our dissemination and communication activities. We will exploit project outputs and facilitate technology transfer for treatments and diagnostics from innovators to African manufacturers. CHAPAS-5 aims to improve health and well-being of CALHIV, to inform clinical guidelines, and to strengthen health systems through capacity development. Our trial platform will provide a long-term resource for studies seeking to improve outcomes in CALHIV.

Keywords: randomised clinical trial,children and adolescents,art naive,art experienced,novel therapeutics
An innovative implantable device and management platform to prevent chronic fluid congestion (FILBERT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 3994993.75
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Pathologic fluid overload is a main clinical complication of congestive heart failure (CHF). CHF is a severe chronic disease affecting ~28 M people worldwide. Around 8 M of CHF patients are resistant to oral medications and undergo frequent hospitalizations to remove extra fluids with aggressive acute treatments, all carrying severe complications. None of these treatments can prevent fluid accumulation. The Israeli SME Paragate Medical has developed FILBERT, a unique implantable peritoneal ultrafiltration system for diuretic resistant CHF patients. It enables 24/7 monitoring and gentle draining of extra fluids in the urinary system, preventing their accumulation. A remote treatment management platform allows physicians to continuously control patients’ conditions and timely adjust therapy to prevent fluid accumulation. FILBERT shifts the paradigm of fluid congestion care from the hospital to the home, improving patients’ quality of life and saving billions to healthcare systems.

Keywords: congestive heart failure,patient care,remote treatment management platform,chronic home care,hydrostatic pressure gradient,peritoneal ultrafiltration,continuous fluid removal,fluid overload,elderly population
Revealing the Hidden Universe: A Comprehensive Study of Low-Mass Galaxies Beyond the Local Group (HiddenUniverse)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 2250000.0
EU funding (EUR): 2250000.0
Participants: 1
Project status: SIGNED

Low-mass (dwarf) galaxies, with masses under a few billion solar masses, hold significant importance in astrophysics. They are the key objects in challenging dark matter models on small scales, yet considerable uncertainties remain in our understanding of their baryonic physics. Dwarfs also hold important clues on early star formation and chemical enrichment, and on the buildup of galaxies and the black holes within them. However, studying them has been hard – their low surface brightness nature makes them challenging to detect using standard instrumentation and survey techniques. Despite decades of research, our understanding of dwarfs primarily relies on those in our galactic neighborhood, orbiting the Milky Way. Recent technological advances have sparked a thrilling era of rapid dwarf galaxy discovery beyond the Milky Way. I propose a research program using two novel wide-field surveys, capitalizing on instrumentation designed specifically for this purpose to transform three key aspects: (1) With data from the Dragonfly Wide Field Survey, I will perform a pioneering study of galaxies down to the ultra-faint regime well beyond the Local Group. I will also utilize proprietary data from the Merian Survey to construct a sample of 100,000 classical dwarf galaxies at a redshift of z=0.05-0.1. These datasets will establish a solid foundation for understanding the census low-mass galaxies; (2) By combining kinematic measurements and dynamical modeling, I will obtain constraints on dwarf’s dark matter halo profiles, shedding light on core vs. cusp structures, dynamical friction, and dark matter on small scales; and (3) Pinpoint the baryonic processes that shape these galaxies by studying their stellar, gas, and star formation properties. With leadership roles in both observational initiatives, an in-depth understanding of the data, and exclusive data access, I'm uniquely positioned to lead this program, timed ahead of future community surveys like LSST, Euclid, and Roman.

Keywords: dwarf galaxies,dark matter in dwarf galaxies,galaxy halo connection,low surface brightness imaging,galaxy surveys,galaxy stellar mass function,star formation
Safeguarding biodiversity and carbon-rich forest networks in Europe (SafeNet)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Finland,Hungary,United Kingdom,Austria,Spain,Norway,Ireland,Netherlands,Germany,Romania,France
Call: Conservation and protection of carbon-rich and biodiversity-rich forest ecosystems (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-02-01
End date: 2029-07-31
Duration (months): 54.0
Total project cost (EUR): 6233145.0
EU funding (EUR): 6233144.0
Participants: 14
Project status: SIGNED

The EU has developed ambitious policies and regulations to halt biodiversity loss resulting from intensive use of forests and land and climate change. Reversing the decline of biodiversity requires safeguarding existing biodiversity and fostering the adaptive capacity and resilience of the ecosystem. SafeNet relies on a portfolio of complementary tools to develop strategies and solutions to protect and foster biodiversity, while considering the need to manage forests for climate change mitigation, wood and ecosystem service provisioning. SafeNet integrates cutting-edge methods in biodiversity monitoring and mathematical modelling with massive remote sensing and species datasets to better understand the climate change induced shifts in the distributions and migration of genes, species, communities, ecosystems under different climate and forest and land use scenarios. This will allow the prioritization and implementation of anticipatory conservation and management measures, including the protection of corridors among the network of primary and old-growth and other ecologically valuable forests. SafeNet implements a multi-actor approach and engages key stakeholders, including policymakers, forest practitioners, regional and national authorities, certification bodies, and forest-value chain stakeholders, in regional Living Labs developed in case study areas covering four biomes across Europe, and a European level Policy Lab. Stakeholders will co-create solutions with researchers to develop sustainable strategies for real landscapes and innovate EU-level strategies and policies to reconcile conservation goals. Methodologies and scientific advances developed by SafeNet, as well as the transdisciplinary team’s expertise in mathematical biology, remote sensing, forest economy and ecology, environmental conflict management, policy analysis and science-policy interaction, and stakeholder engagement and dissemination-outreach, ensure the success of SafeNet and its impact.

Keywords: bio monitoring,connectivity,remote sensing,primary and old growth forests,sustainable forestry,joint species distribution modelling,forest models,protection areas,multi source optimization
From low- to high-cost cooperation: Increasing costly cooperation behavior through internalized low-cost prosociality (SoMiCoop)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-09-30
Duration (months): 37.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

The question how to increase cooperation behavior to encounter current societal challenges is an ongoing research endeavor in several empirical disciplines, such as behavioral economics, social psychology and beyond. Classic nudging approaches modify the situation in a way that the decision maker is slightly influenced in her decision, though maintains complete freedom of choice, as is the case when modifying the default. This comes at the downside, however, that in ultimate consequence, every decision would need to be nudged. In SoMicoop, I present a new and generalized approach, focusing on daily-life kindness as a form of low-cost cooperation. Until recently, the investigation of low-cost cooperation in social psychology and behavioral economics has largely been neglected. I aim to close this gap, investigating whether and how low-cost cooperation can actually be used to increase costly cooperation. Having shown in preparatory studies that low-cost cooperation can be trained and that it is related to high-cost cooperation, I aim to investigate how low-cost cooperation can be internalized in such a way so that it spills over to costly cooperation. Utilizing cutting-edge methodologies (i.e., eye-tracking and experience sampling) allows me to investigate underlying cognitive processes and boundary conditions, how and when trained low-cost cooperation generalizes to high-cost cooperation. Most importantly, I validate the results of trained low-cost cooperation outside the laboratory (i.e., via experience sampling). This yields an important scientific contribution that can have important implications for how we aim at promoting cooperation in the lab and in daily life.

Keywords: cooperation behavior in social dilemmas,social mindfulness,pro sociality,social preferences,cognitive processes
Neoantigen Identification with Dendritic Cell Reprogramming (NeoIDC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-04-01
End date: 2024-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In cancer, genetic mutations result in production of tumor neoantigens restrictively expressed in transformed cells and serve as ideal molecular targets for cancer vaccines and adoptive T cell therapies. However, available methods for the identification of clinically relevant neoantigens driving potent anti-tumor immunity are highly inefficient. Thus, there is an urgent need for innovative solutions to identify powerful immunogenic neoantigens to unlock the full potential of immunotherapy and treat currently untreatable cancers. The NeoIDC platform has the radical vision to use the type 1 conventional dendritic cell (cDC1) reprogramming technology, arising from the ERC-funded project TrojanDC, to directly identify highly immunogenic tumor neoantigens and neoantigen-specific T cell receptors (TCRs) for the development of powerful cancer vaccines and adoptive T cell therapies. To achieve this, we will firstly identify tumor peptides presented on MHC class I and II by cDC1-reprogrammed cancer cells and validate immunogenicity in vivo. Secondly, we will expand neoantigen-specific T cells by co-culture with reprogrammed cancer cells, sequence TCRs and link to cognate neoantigens. This will facilitate the generation of potent cancer vaccines and tumor-reactive T cells for adoptive transfer. Experimental activities with collaborators and clinicians will be coupled with exploitation plans including partnership with Asgard Therapeutics, ensuring commercialization by generation of novel IP, broad and targeted dissemination and a new start-up company. NeoIDC combines cDC1’s antigen processing and presenting abilities with the unique mutational profile of cancer cells to enable the direct identification of immunogenic neoantigens and cognate TCRs. Ultimately, this project will enable the development of the next generation of neoantigen-based vaccines and adoptive T cell therapies and will set the stage for a new era of safe, personalized and effective cancer immunotherapies.
Vulnerability Exposure Analysis for JavaScript (PAWJAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-07-01
End date: 2024-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The JavaScript programming language together with the Node.js framework constitute the foundation of modern web-based software. An essential part of this platform is the npm registry that contains millions of freely available third-party software libraries that provide common functionality. This massive reuse of libraries is essential to the productivity of software developers, however, the dependence on other people's libraries opens the door to security vulnerabilities that may have severe consequences to the applications and end users. When new vulnerabilities are discovered, it is thus crucial that the programmers are informed. Existing tools only tell whether a program depends on libraries with vulnerabilities, but without precise information about how the vulnerable library code is being used, which causes an overwhelming amount of false positives and makes it extremely difficult for the programmers to investigate the possible consequences of the vulnerabilities. The ERC project PAW has delivered a range of novel program analysis techniques, most notably one that has the potential to alleviate this problem: The analysis tool JAM is capable of automatically analyzing a given JavaScript program and tell exactly which parts of the libraries are being used and where they are used, thereby enabling the programmers to make fast and correct decisions about how their programs are exposed to vulnerabilities and how to update their programs accordingly to prevent security incidents. The proposed project, PAWJAM, aims to explore the commercial and innovative aspects of this program analysis tool, by further developing the prototype implementation into a commercial product, performing more extensive evaluations of its effectiveness, and engaging with potential users and industry partners.
Harnessing Ammonia Reactivity Via PhotoElectrochemical Splitting by Molecular CaTalysts (HARVEST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

With the global production of ammonia playing a pivotal role in food and chemical industries, the nitrogen cycle is essential for sustaining modern life. However, the challenging nitrogen redox chemistry demand innovative solutions for sustainability. HARVEST aims to advance our understanding of the ammonia oxidation reaction (AOR) by designing molecular catalysts for efficient NH3 splitting. With only incipient progress made in AOR molecular catalysis, HARVEST will systematically target new iron and manganese catalysts for the AOR. These will be integrated into dye-sensitized (photo)electrochemical cells (DSPEC) for solar conversion. Thus, HARVEST not only promises to advance our knowledge on nitrogen chemistry, but also holds potential for carbon-neutral fuel production and energy storage. For the postdoctoral candidate, HARVEST marks a critical phase in career development. With prior multidisciplinary experience, the focus now shifts to building a solid profile in molecular electrochemistry and photoelectrocatalysis. HARVEST includes a flexible training program, targeting teaching, management, and supervision roles, vital for future research leadership positions. Overall, this research not only will advance sustainable technology but will also nurture a versatile and skilled researcher ready to contribute significantly to both academia and industry research units.

Keywords: molecular elmolecular electrocatalysis transition metal catalyst ammonia oxidation artificial photosynthesis nitrogen cycle hydrogen fuel solar fuel ammonia splitting photoelectrochemical cell
Boosting Europe’s sustainable battery cell industrial manufacturing value chain by developing an optimised machinery with intelligent control processes to minimise costs, scrap and energy consumption (BATMACHINE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Belgium,Spain,Germany,Denmark,Italy,Norway,Türkiye
Call: Towards creating an integrated manufacturing value chain in Europe: from machinery development to plant and site integrated design (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-06-01
End date: 2026-11-30
Duration (months): 42.0
Total project cost (EUR): 7219541.66
EU funding (EUR): 5645321.5
Participants: 12
Project status: SIGNED

The core vision of the BATMACHINE project is centred on strengthening Europe’s battery cell industrial manufacturing value chain by developing new battery cell manufacturing machinery. This is done whilst giving priority to minimising the energy energy for cells production, enhancing plant efficiency rates and integrating intelligent control processes to reduce scrap. BATMACHINE will develop and implement an optimised and energy-efficient process chain considering: • Slurry mixing (automated modular process set-up including monitoring techniques); • Exclusive slot-die coating and drying novel machinery (with one side coating, a coating speed of 1m/min up to 20m/min and a web-width of 300 mm); • Together with a calendaring tool to be integrated in a battery manufacturer for process optimisation. Moreover, intelligent control processes and Industry 4.0 will be intensively integrated through the creation of a collaborative and FAIR data space for battery production. Digital interfaces between battery manufacturing equipment, control system, and engineers will be developed with the aim of building universal digitalisation tools to enhance the battery production and create a battery passport. The environmental and economic impact of different machinery, production line configurations and factory designs will be deeply studied to reduce the cost and energy consumption of manufacturing processes.

Keywords: battery,manufacturing,energy,digitalisation,slurry mixing,coating,drying,calendaring,sustainability,standards,supply chain,industry 4 0,smart