Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improving the safety of live attenuated viral vaccines by exploiting RNA silencing pathways (VIVARNAsilencing2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-07-01
End date: 2022-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Live-attenuated viral vaccines are among the most successful vaccine approaches and have been used for decades. However, live-attenuated vaccines come with a risk of reversion or recombination of the vaccine to a virulent form. An important consideration for live-attenuated vaccines for arthropod-borne (arbo-) viruses is that they should not replicate in their mosquito vectors to prevent unwanted spread of the vaccine and vaccine-derived virulent strains. In this ERC Proof-of-Concept project (VIVARNAsilencing2), we will develop an innovative approach to enhance the safety of live-attenuated vaccines for mosquito-transmitted viruses, by preventing their replication in mosquitoes. To this end, we will exploit a small RNA-based gene regulatory network of the mosquito vector to target viral RNA for degradation in the mosquito. The mechanism and natural function of this gene regulatory network had been characterized in an ERC Consolidator Grant, which we will now develop into a commercial and societal valuable product. We will focus on important epidemic human arboviruses with a large disease burden such as dengue virus, Zika virus, and chikungunya virus, but the approach is readily applicable for all arboviruses that are transmitted by mosquitoes of the Culex and Aedes genera, including pathogens of livestock. VIVARNAsilencing2 meets an urgent need in the face of the enormous disease burden and strong global push to develop vaccines for the important class of mosquito-transmitted pathogens.

Keywords: viral vaccine,live attenuated vaccine,rna silencing,piwi interacting rna,arbovirus,mosquito,aedes,aegypti
Reading Literature in a Digital Culture (READIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Korea, Republic of
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2021-11-30
Duration (months): 36.0
Total project cost (EUR): 268741.8
EU funding (EUR): 268741.8
Participants: 2
Project status: CLOSED

The digitisation of culture is having a negative effect on the amount of time spent reading literary texts. Literacy has been identified as a key factor in the EU’s growth strategy (Europe 2020) and the improving of reading skills is an issue to be addressed urgently. To face the issue of reading in a digital culture, we need to study the experience of reading, also considering that millennials are a different kind of readers: they are not attracted by traditional printed books, therefore we need to understand what kind of readers of literature they can be and design paths that can bring them to the experience of reading literature. My hypothesis is that we can use digital media to make reading more appealing. The challenge is precisely how to do that without introducing further elements of distraction. The focus of this project is on the experience of reading literary texts in the context of a digital ecosystem, and aims at answering to the questions: A. How can we use digital tools to better understand how digital culture is transforming youth’s engagement with literature? B. How to improve the engagement with literature in an era dominated by digital culture? In order to set the ground for later more comprehensive answers, my project will focus on two kinds of Digital Literary Experience: online social reading (a form of reader participation in the flowing process of text production-reception) and literary digital environments (simulated spaces created using one or more digital devices in order to provide a multimodal experience of literature). The feasibility of the project depends on the complementary training I will receive in South Korea and Italy. At Sogang University I will have the opportunity to learn how to develop digital environments designed specifically for reading literature. At the University of Milan-Bicocca, I will improve my knowledge of how to do research focused on the reading experience, from an evolutionary perspective.

Keywords: online social reading,literary experience,reading,virtual reality,digital humanities
Generation and Evolution Of Transform-Ridge Interaction and Behavior on Earth (GEOTRIBE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Transform-ridge orthogonal patterns are fundamental features of the Earth’s plate tectonics. Although transform faults play a critical role in the organization of plate motions and are seismically active boundaries, it is still enigmatic how they form and why they are maintained. So far, only regional-scale models of transform fault inception and evolution exist. As the result, relationships of these structures with global mantle flow and large-scale plate kinematics remain unknown. The aim of this project is to advance our knowledge on global physical controls for the transform-ridge systems inception, dynamics and variability. I will take into account global forces to investigate nucleation and evolution of transform-ridge interactions, thus bridging the gap between regional and global models. I will use my long-term expertise in geophysical modeling to implement new physics (such as rock damage and magmatism) in the state-of-the-art convection code developed at ETH Zurich. I will run high-resolution 3D spherical models of global mantle convection to build the first database of simulated global transform-ridge patterns showing what factors influence the spacing and offset of transform faults. I will develop methods to compare the synthetic data with collected observed field data (bathymetry, gravity data, seismicity) to assess which physical processes (e.g. crustal melting, rock healing) control the formation and distribution of ridge-transform centers. Accounting for the global mantle and plate tectonic forces to explain transform fault dynamics is an unprecedented approach that is possible only now due to advances in physical properties of mantle rocks, numerical technics and increasing available computational power. Through this multidisciplinary project I aim at the first assessment of how transform-ridge system guides the evolution of plates for long periods with the scope of keeping Europe at the vanguard of the tectonics and geodynamical modeling research.

Keywords: mantle convection,rheology,lithosphere,transform faults,plate tectonics,oceanic spreading,mid ocean ridge,numerical models,computational physics
Diagnostics of sleep disorders for all patient groups (Sleep for All)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Iceland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 2883150.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Nox Medical will develop and bring to market disruptive technology in sleep diagnostics to address an epidemic which costs Europe more than € 300 billion annually. Nox Medical is a leading company in the field of sleep diagnostics equipment. Based on our experience and market positioning we plan to revolutionize sleep diagnostics by improving the diagnostic power of our products and making them accessible to a much larger market. Current sleep diagnosis methods and criteria are based on findings which were made before computers were common place in the hospital environment. Since then, a range of biomarkers and diagnostics protocols have been discovered, validated, and published in scientific journals. These biomarkers and diagnostics protocols have not been integrated into routine diagnosis. This is partly due to technological challenges and partly due to the conservative nature of medicine. By adopting these biomarkers and diagnostics protocols into state of the art diagnostics products, Nox Medical is bridging the gap between research and clinical application. The resulting products will allow more sleep studies being performed in the home environment, instead of being performed inside a hospital. This will allow better patient stratification, reduction of cost, and make sleep diagnosis available to a much larger market. The results of the project open up a possibility of revolutionising the business model behind sleep diagnostics by offering sleep diagnostics as a service, similar to a model commonly used in software marketing today.

Keywords: sleep,diagnostic,medical devices
Cost-effective microfluidic electronic devices for optimal drug administration based on fractional pharmacokinetics for leukemia treatments (MEDLEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Australia,Germany,Thailand,Serbia,France,France
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 333000.0
EU funding (EUR): 283500.0
Participants: 6
Project status: CLOSED

The project entitled: “Cost-effective microfluidic electronic devices for optimal drug administration based on fractional pharmacokinetics for leukemia treatments”, with acronym MEDLEM, has a general objective to foster exchanging knowledge and sharing different culture and approaches in reaching high level of excellence, in research and innovation, in the framework of this field. The project is aimed at strengthening research collaboration through active networking, staff exchange and dissemination activities between 4 European organizations from Serbia, Germany and France as well as 2 non-European institutions from Thailand and Australia, in linking the fields of microfluidic electronic devices, optimal drug administration, fractional pharmacokinetics, and leukemia treatments. The project will exploit complementary competencies and synergies of the participants, and enable knowledge sharing via international/inter-sectoral mobility, based on secondments of research staff. The consortium offers a unique opportunity that creativity and entrepreneurship will flourish and will help exchanged personnel to turn creative ideas into innovative electronics products, reaching breakthroughs in modelling, drug administration and improvements in therapy protocols. The main technical goals of the joint research programme are: - Development of fractional pharmacokinetic models and procedures for parameter identification within these models; - Design and fabrication of microfluidic device with in-built electronics for optimal drug delivery protocol; - Pharmacokinetics determination of the pharmaceuticals for leukemia treatments and its testing in vitro and in vivo systems; - Optimal control problem, its numerical solution and implementation. The proposal will develop new research links and strengthen the current research links among the partners and will help build up long-term, world-class research in more successful leukemia treatments.

Keywords: rapid prototyping,fractional pharmacokinetic,leukemia treatment
Understanding Life Trajectories of Immigrants and Their Descendants in Europe and Projecting Future Trends (MigrantLife)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Sweden,United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-08-31
Duration (months): 72.0
Total project cost (EUR): 2446523.75
EU funding (EUR): 2364895.0
Participants: 2
Project status: SIGNED

In recent decades, European countries have witnessed increasing immigration streams and ethnic heterogeneity of their populations. Facilitating immigrant integration and social cohesion has become a major societal issue. The project moves beyond previous research by first investigating how employment, housing and family trajectories evolve and interact in the lives of descendants of post-WWII immigrants and post-1990 immigrants in the UK, France, Germany and Sweden, and how factors related to a societal context, an early life context and critical transitions shape their life histories. Second, the study will project their future life trajectories using innovative simulation techniques, considering the main life domains and diversity between and within immigrant groups. Although recent studies report substantial diversity in employment, in housing and in family patterns among descendants of post-war immigrants and recent immigrants in Europe, the causes of this heterogeneity remain far from clear. Furthermore, it is not known whether observed differences between immigrants and natives are short-term outcomes in a long-term process of cultural and economic integration or rather reflections of different pathways and outcomes for immigrants and their descendants. The project will exploit large-scale longitudinal data from four countries and apply advanced longitudinal methods, including multichannel sequence analysis and multilevel event history analysis. Microsimulation will be applied to project life histories for immigrants and their descendants. The project will significantly deepen our understanding of the relationships between the three life domains, and the causes of less and more successful life trajectories among immigrants and their descendants. This project will show whether the current heterogeneity between and within immigrant and minority groups vanishes over time or rather persists, suggesting an increasing diversity of European societies.

Keywords: immigrants,second generation,employment,family,housing,longitudinal analysis,microsimulation
Secure software implementation of an eSIM (Helios-Plugin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The eSIM is a form of integrated SIM soldered directly onto the circuit board of a connected or mobile device, and thus CANNOT and NEEDNOT be removed from the device. The eSIM has great potential in network authentication because of the immense benefits it offers to users. Its potential can be enhanced by synthezing its inherent features with further technological developments to ensure multi-application operability and migration from hardware. Current eSIMs are hardware dependant and can only be implemented as a soldered Secure Element (SE) in the device. As a result, they cannot be deployed on existing devices, making old devices obsolete. Additionally, each SE is currently linked to one application, meaning that a single user will need multiple eSE on different devices which is costly and inconvenient. An unmet opportunity has thus been identified for developing a multi-application software based eSIM that will enable maximum exploitation of the eSIM technology. OSSE has identified this opportunity and has developed the Helios-Plugin, a GSMA compliant secure SOFTWARE implementation of an eSIM. The Plug-in will be combined in usage with a multipurpose, SE but can however be deployed on an SE mounted on an existing device. Helios-Plugin enables the use of the SE for multiple purposes e.g. payment or transport applications which reduces TCO of eSIM from €1 to below €0.85/unit for OEMs and also reduces cost of SIM replacement by 94% (€5 to €0.3). The eSIM plug-in software can dynamically be downloaded and updated, enabling the user to benefit from bug fixing and feature updates. Helios-Plugin is at an advanced stage of development having been demonstrated with NXP. During Ph1, we will develop a road map to finalise Helios-Plugin and Ph2 will see us developing and validating the market version. Our turnover will come from royalties for each device deployed with Helios-Plugin. We target to achieve a cumulative turnover of €12.5M by the 5th year of commercialisation.

Keywords: esim,embedded universal integrated circuit card,embedded operating system,mobile network operators,oems,secure element,gsma,internet of things,machine to machine
The new flow of news : how social network sites transform news organization and citizens political behavior (SNSNEWS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2023-03-31
Duration (months): 84.0
Total project cost (EUR): 1499044.0
EU funding (EUR): 1499044.0
Participants: 1
Project status: CLOSED

News industry is undergoing a major transition: Traditional news consumption is on the decline, while citizens increasingly turn their attention to social network sites (SNSs). To accommodate this trend, news industry has been incorporating SNSs into its platforms, changing news into a social product. The project will explore this process and reveal its implications for news production and audiences’ political behavior. I develop a new model anchored in network logic and involving three key actors in news creation and distribution: news organizations, which are adapting news production to the logic of sharing; news feeders – users who select and disseminate news stories, thereby serving as a bridge between their online followers and news organizations; and news feedees – individuals whose news consumption is limited to stories fetched for them by feeders in their SNSs. The model points to some long-term effects on individuals' political beliefs and behavior as a consequence of acting as feeders or feedees. Multiple innovative methods will be employed, some of which will be implemented in the field of media and political studies for the first time. The methods are mutually complementary, combining ‘big data’ analysis with small-N in-depth designs. To study news organizations, I will interview news editors and analyze traffic data juxtaposing it against content analysis. To study users’ behavior and identify feeders and feedees, I will conduct a laboratory observation in which surfing behavior and physiological attention indices will be measured unobtrusively. Long-term political effects will be tested using a combination of survey panel data and web-based behavioral data spanning a period of two years. The proposal is theoretically and empirically innovative and can impact future research by providing novel conceptualization of news distribution, consumption and influence, as well as by introducing a new methodological ‘golden standard’ to audience research.
Transdiagnostic views on eating disorders and obesity and new approaches for treatment (NewEat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Austria
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1327016.25
EU funding (EUR): 1327016.25
Participants: 1
Project status: CLOSED

Eating disorders such as Anorexia Nervosa (AN), Bulimia Nervosa (BN), Binge Eating Disorder (BED) and overweight/obesity are highly prevalent in the EU and worldwide. They cause tremendous suffering, elevate suicide rates, and account for multiple organic effects that increase all-cause mortality. Etiological and maintenance factors are not well understood and transdiagnostic theoretical models across eating and weight disorders are largely missing. The present project aims to develop an integrated theoretical framework by studying psychological factors that contribute to non-homeostatic eating across the full spectrum of eating-related disorders. It is proposed that high levels on psychological traits such as restraint eating (i.e., chronic dieting behaviour), emotional eating (i.e., eating in response to negative emotional events rather than hunger), craving/food addiction (i.e., intense and chronic urge to consume palatable foods), impulsivity (i.e., inadequate food consumption planning and low self-control), and low self-esteem influence neural systems that balance appetitive (mostly bottom-up) with regulatory (mostly top-down) processes. This model is tested in the four patient groups and healthy controls utilizing an integrated set of assessment methods, involving psychometric testing, smartphone based ambulatory assessment, and neurocognitive laboratory measurement. Derived from this model, novel behavioural interventions such as smartphone based stimulus control and cognitive inhibition training will be developed. Results will have implications for theoretical models of eating and weight disorders as well as for neuroaffective models of appetite regulation. Smartphone technology might usefully complement current interventions in supporting an effective transfer to daily life and help alleviate the burden for patients with eating-related mental and physical diseases.

Keywords: bulimia nervosa,anorexia nervosa,binge eating disorder,obesity,overweight,fmri,food,eating,restraint eating,emotional eating,impulsivity,self esteem,craving,food addiction