Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Industrial symbiosis for valorising whey and banana wastes and by-products for the production of novel foods (SYBAWHEY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Uganda,Cyprus,Greece,Switzerland,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 310500.0
EU funding (EUR): 310500.0
Participants: 7
Project status: CLOSED

It is more efficient to maximise the value of food waste and by-products than reducing the cost of its management and disposal. Applications in this direction require intersectoral and intrasectoral synergies for maximising utilisation of complementary waste resources and multidisciplinary approach to research innovation and skills. SYBAWHEY aims a trans-national partnership between Europe and Africa for promoting area-wide sustainable supply network for the generation of innovations in the direction of food waste management and valorisation. The main focus will be on exchange of material (waste and by-products) and non-material based resources (knowledge and transferable skills) via international as well as intersectoral mobility between Africa and Europe. Methodologically, it draws on a case study of high volumes of underused by-products and wastes from banana production in Uganda and the environmentally toxic cheese whey produced by Cyprus dairies. Compared to other regions, whey from Cypriot dairies presents high lactose content and therefore great potential for product-driven biorefining. Moreover, banana flavour is one of the most preferred flavours in dairy products. SYBAWHEY aims a multidisciplinary approach to the network including assessing the feasibility and impact of whey and banana waste and by-product valorisation into useful products with high input to the same or different industrial plants; development of innovative technologies for aroma extraction from banana pulp and peel to be used in dairy products; characterisation of whey and banana pulp and peel and development of bioprocesses for their utilisation in health-promoting fermented whey-based novel foods; assessing the sustainability of banana flour in terms of energy and resource use as well as assessing the sustainability of the proposed valorisation processes by evaluating their economical, environmental and social impact.

Keywords: hallumi cheese whey,banana peel,banana pulp,product driven refining,bio based products,yogurt like products,sustainability assessment,industrial symbiosis
THE ROLE OF YOUTH IN PEACEBUILDING: THE CYPRUS CASE (YOUPEACEBUILDER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The lasting separation between Turkish and Greek Cypriots on the small island of Cyprus has long been one of the contentious issues of the Eastern Mediterranean. Much effort and energy has been spent trying to find a comprehensive resolution to the dispute. However, the rationale behind the strategy of conflict resolution, which has been mainly based on negotiations between subsequent leaders, remains problematic. The lack of (or limited) direct involvement of societies, particularly disengagement of young people, who have lived in an ethnically divided country since they were born, has prevented mobilization of Cypriot youth in their search for communication and interaction. However, current peacebuilding efforts on the island still focus on reaching an agreement between leaders instead of finding ways to engage the youth of both sides, who are expected to live together despite the fact that they have never experienced it before. As McEvoy-Levy suggests “a peace agreement’s endurance depends on whether the next generations accept or reject it, how they are socialized during the peace process, and their perceptions of what that peace process has achieved.” As the most recent addition to the international community’s repertoire of conflict resolution methods, peacebuilding simply refers to a comprehensive process that tries to remove the root causes of a conflict. According to Lederach, the actors at the national and international top levels are involved in negotiation and peacemaking, while the grassroots, bottom-up level are aiming to promote peace and reconciliation at local and society level. Thus, the linkage between the top and grassroots levels, in which middle-level process aims to facilitate, is essential for an effective and sustainable peace. This research proposal aims to discover, observe and reshape the correlation between youth and peacebuilding particularly in the Cyprus case by borrowing Lederach’s approach on peacebuilding.

Keywords: peacebuilding,the role of youth,the cyprus dispute,conflict transformation,peace studies
HUMAN UTERUS CELL ATLAS (HUTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Estonia,Sweden,United Kingdom,United Kingdom
Call: Pilot actions to build the foundations of a human cell atlas (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2022-06-30
Duration (months): 30.0
Total project cost (EUR): 4118942.5
EU funding (EUR): 4118942.5
Participants: 7
Project status: CLOSED

The Human Uterus Cell Atlas (HUTER) project aims to create the single-cell and spatial reference map of the human uterus. HUTER project will provide unprecedented insight at transcriptomic, genomic and spatial changes of this important female organ not only throughout the menstrual cycle but also across lifespan. The human uterus is a flagship reproductive organ with profound implications not only in reproduction but also in women´s health. HUTER can advance the Human Cell Atlas initiative for the exploitation potential in Obstetrics and Gynaecology and biomedicine research areas such as Regenerative Medicine or Reproductive Medicine. The uterus is itself a model for regenerative medicine since (i) endometrial tissue regenerates monthly and its transformation is executed through dynamic changes in states and interactions of multiple cell types, and (ii) myometrial tissue has remarkable regenerative capacity and extensive remodelling throughout pregnancy. Hence, the primary motivation HUTER proposal stems from the need to better understand the human uterus in order to more effectively address uterine diseases that impact women´s health such as myomas or endometriosis and/or might contribute to infertility, infant and maternal mortality and morbidity. HUTER technological and biological platform will be a crucial resource for the scientific and clinical communities to define the cellular basis of health and disease, allowing the rapid development of new diagnosis and prognosis tools and therapeutic advancements in the field.

Keywords: immunohistochemistry,immunofluorescence,uterus,myometrium,endometrium,spatial transcriptomics,single cell rna sequencing,methylation profiles
Reducing the cost, time, and ethical burden of preclinical research in the pharmaceutical industry (GENBIO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2021-08-31
Duration (months): 36.0
Total project cost (EUR): 3464750.0
EU funding (EUR): 2425325.0
Participants: 1
Project status: CLOSED

Recent advances in genomics, molecular science, and big data are changing the way we define and target diseases, but drug discovery is still a time-consuming, expensive and risky process. Genome Biologics provides a unique combination of tools – GENIMAPS and GENISYST – to provide an integrated platform, with a disruptive effect on the time, cost and risk of drug discovery and pre-clinical trial development. GENISYST uses a unique transgenic methodology to allow up to 50 genes to be expressed in one animal, directly in target tissue, without affecting the genome. This methodology removes the need for breeding, radically reducing the number of animals needed to make a transgenic animal model by a factor of 100, and enables transgenic large animal models, a current commercial gap in the market. The toolkit reduces the time to prepare animal models, and the cost of drug discovery and pre-clinical trials, by an order of magnitude. The impact of this is cheaper, more rapidly developed, drugs, with a greater target to market success rate. GENIMAPS combines big data, AI and a unique multi-omics approach to make rapid and precise matches between disease indicators and compound behaviours, allow rapid identification of targets, genetic expression, and compound matches. As well as precision medicine, GENIMAPS also allows the rapid evaluation of an existing pipeline, allowing repositioning of a company’s existing, FDA approved assets (or orphan drugs) – increasing the return on public and private investment.

Keywords: transgenic,animal models,animal studies,pre clinical studies,ethical burden,big data,artificial intelligence
DELIVEr Renewable Energy and Energy efficiency projects in Dublin (DeliveREE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Ireland,Ireland,Ireland,United Kingdom
Call: Aggregation - Project Development Assistance (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 1174661.25
EU funding (EUR): 1174661.25
Participants: 8
Project status: SIGNED

The current approach to upgrading public buildings in Dublin is ad hoc and while energy and green house gas (GHG) emissions savings are being achieved it is not happening at the speed or scale necessary to meet Ireland’s EU obligations. Codema, Dublins Energy Agency, want to address these problems through innovative project aggregation (scale), contracting structures (speed) and financing (capital) to accelerate and de-risk the Delivery of Renewable and Energy Efficiency projects across Dublin (DeliveREE). DeliveREE is an innovative project finance and delivery structure for renewable energy and energy efficiency projects in Dublin using performance contracting structures. By creating a structured approach DeliveREE will accelerate the formation of large-scale projects by standardising the project development process allowing projects of various types to be aggregated together to create scale. This enables the use of energy performance and energy supply contracts whose performance guarantees are both critical for achieving value for money and provide a mechanism for the involvement of private capital. Through DeliveREE Codema aims to build upon this experience and create a structure that will facilitate the investment of much needed private finance into public projects in order to scale-up, de-risk and accelerate the energy efficient refurbishment of public buildings and the development of renewable energy projects with the intention to roll-out to private sector commercial and residential buildings across Dublin. DeliveREE aims to trigger €20.4m investments into a series of over 140 sustainable energy projects leading to a reduction of 3,977 tCO2-eqyear.

Keywords: climate change,project aggregation,energy performance contract,energy agency,local government,ireland,dublin,energy bonds,energy guarantee,renewable,project development office
Advanced holographic optical neural stimulation for vision restoration and basic research (HoloVision)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 2624517.0
EU funding (EUR): 2624517.0
Participants: 1
Project status: CLOSED

When natural sensory input is disrupted, as in outer-retinal degenerative diseases, artificial stimulation of surviving nerve cells offers a potential strategy for bypassing compromised neural circuits and substituting sensory perception. Current neuro-stimulation interfaces that use electrical currents from micro-electrode arrays are already being clinically applied for retinal stimulation, but their performance is ultimately limited by current spread and the requirement for physical contact with an implanted device. Future minimally-invasive systems could use light patterns to photo-induce complex yet precise spatio-temporal activity patterns among surviving retinal neurons, with the ultimate potential of restoring vision to a nearly normal level. Here, we will advance, optimize and test in vivo a powerful new strategy for cellular-resolution controlled patterned optogenetic excitation, based on computer-generated holographic optical neural-stimulation (HONS). Regular (one-photon) HONS systems can dynamically address large populations of optogenetically-transduced retinal ganglion cells with single-cell resolution, while related multiphoton HONS systems can extend these capabilities to three-dimensional cortical tissue (relevant to many research applications). A series of in vivo experiments will resolve basic questions regarding the efficacy of these approaches by directly examining the retinal and cortical responses to structured holographic photo-stimulation, and test novel strategies for improving it. Finally, as a major step towards clinical translation of this technology, we will design and evaluate (in blind sheep and sighted individuals) a human-scale prototype. Overall, by combining both basic and translational research, this study will advance novel optical neuro-technologies with potential impact on multiple scientific and clinical applications. Specifically, it will tackle the major engineering requirements and constraints towards the development of a
hapticom launches the world‘s 1st special tablet for over 20 million visually impaired people in the EU, enabling them access to barrier-free digital information and communication with all of society (Ph1ProHap2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Within the EU there live far more than 20 million blind and partially sighted people. There are even over 150,000 deafblind people who miss out seeing AND hearing at the same time. Most of the blind suffer from strongly limited communication and often live in huge social isolation. Even the UN and also EU parliament have already stipulated that a specific product solution for particular blind is needed. This mobile device ought to offer barrier-free communication and information to assist those people daily lives. Therefore, the SME hapticom, an academic spin-off, develops the world‘s first smartpad and corresponding ICT infrastructure for visual impaired. The device is named haptiPad and similar to a special haptic multi-functional pad or tablet. This innovation will change the life of blind people in whole Europe radically and strongly foster integration and inclusion. Due to the groundbreaking chances the haptiPad offers, it addresses a huge market. High social gains, employment and commercialisation potential can be expected. Via several governmental fundings and the international investor Wayra (Telefonica telecommunications group) a convincing working prototype (TRL 6) is already developed and successfully tested. Due to several (inter)national business concept contests the innovative business model of hapticom got very challenged and thus, advanced and was rewarded highly many times. The competent team intends to prove the adaptability and viability of the project’s concept and product solution on a European level with the help of a feasibility study. At the end of phase 1 SME instrument hapticom aims for reference customer for the commercial beta version of the haptiPad to finally successfully finance the growth of the venture.

Keywords: information,communication,service,device,smartpad,blind,visual handicapped,barrier free,integration,inclusion,worldwide,high potential,high revenues,employment
Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils (smartCC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-06-01
End date: 2019-09-15
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Smart interfaces alter their properties in response to an external trigger. Such devices open exciting opportunities for novel technologies with manifold applications. Electrical fields pose easily controllable triggers for smart interfaces and even allow a precise 'digital' switching between 'on' and 'off' states. The research project ‘smartCC’ will employ a biologically abundant class of biomacromolecules – coiled-coil peptides – to prepare smart selective interfaces, whose ability to specifically bind targets can be switched reversibly. Moreover, the produced interface will constitute a highly sensitive sensor by application of the attenuated total reflection infrared reflection technique. The variability of coiled-coils, employed in numerous biological systems, will also extend the potential application bandwidth of smart interfaces significantly. Molecular details of the switching and binding behaviour of the coiled-coils at the interface will be studied to test the feasibility of the envisioned working principle. Furthermore, the novel devices will be tested for an application with industrial relevance. To reach the goals of ‘smartCC’ a highly interdisciplinary approach is chosen that includes cooperation between three academic and one non-academic European partners. Thus, the implementation of this project will support bringing an emerging technology towards an economical benefit, foster intra European collaborations and mobility as well as strengthen Europe’s scientific sector.

Keywords: coiled coils,smart interfaces,self assembled monolayer,atr ir spectroscopy,electric switching
Epigenomic Reprogramming of Adipose Tissue Function and Energy Metabolism in Type 2 Diabetes (EpiFAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Obesity is associated with adipose tissue dysfunction leading to the onset of several pathologies including type 2 diabetes (T2D). The mechanisms underlying the development of obesity and T2D include the hypertrophy and/or hyperplasia of adipocytes and adipose tissue inflammation together with an altered secretion of adipokines. However, the explanation of why individual obese (and some non-obese) humans differ in their susceptibility to develop T2D is still an issue that is currently not sufficiently addressed. This susceptibility to T2D is mainly associated with environmental factors. One link between environment and disease is epigenetics influencing gene expression and subsequently organ dysfunction. Epigenetic modifications in adipose tissue have been proposed to influence the susceptibility to T2D. However, the epigenomic mechanisms underpinning adipose tissue dysfunction are poorly known. In search for epigenomic modifiers that control adipose tissue function and also impact on T2D pathogenesis, we have recently identified the transcriptional coregulators GPS2 (G-Protein Pathway Suppressor 2) and KDM6B (Histone Lysine Demethylase 6B, also called JMJD3) as strong candidates.. Our hypothesis is that the clinically documented dysregulation of GPS2 (down) and KDM6B (up) expression and function during obesity leads to the closely linked epigenetic and transcriptional reprogramming of adipocytes and adipose tissue-macrophages, thereby enhancing the susceptibility to metabolic and inflammatory disturbances and the progression towards T2D. We propose here to test this hypothesis using the combination of unique mouse models, genome-wide molecular and epigenomic analyses and human studies to dissect the epigenomic functions of GPS2 and KDM6B in adipose tissue, aiming at identifying mechanism involved in the development T2D. Thereby, we anticipate the discovery of novel epigenomic targets for future prevention and treatment strategies in metabolic dysfunction.

Keywords: type 2 diabetes,adipose tissue,transcription,coregulators,inflammation and metabolism