Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Creating synergies in Widening countries on the topic of low-voltage grid management (SynGRID)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Slovenia,Greece,Croatia
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 1170375.0
EU funding (EUR): 1170375.0
Participants: 5
Project status: SIGNED

SynGRID project aims to enhance institutional and regional innovation in Widening countries through the capitalisation of outcomes from completed Horizon 2020 and ongoing Horizon Europe projects. The combination of valorisation of research results with the focus on enhancing the management, observability and controllability of low-voltage grids considering the increased integration of Renewable Energy Sources, will be combined with the transparent sharing of the know-how to foster stronger collaborations between renowned research and innovation institutions and HE beneficiaries in Croatia, Greece and Slovenia. The outcome of the international collaboration will be materialised in a joint ERDF, HE and LIFE project proposals that will aim to bridge the gap between European and regional funding mechanisms. To unlock the full potential of R&I actors, the SynGRID project will employ a multi-faceted capacity-building strategy supported by a comprehensive analysis, encompassing a review of validated research outcomes from Horizon projects and an assessment of the current technology landscape in Croatia, Greece, and Slovenia to identify areas requiring intervention. SynGRID will engage key stakeholders including DSOs, regional authorities, SMEs in the energy sector, and research institutions. The backbone of knowledge sharing is structured around key projects like H2020 – COMPILE and X-FLEX, as well as HE – STREAM and OPENTUNITY, where partners served as coordinators or technical coordinators offering advanced insights into the topic of optimised grid reinforcement and advanced controllability to enable large share of RES in the existing, congested DSO grid together with algorithms for fair sharing of limited capacity.

Keywords: advanced management of low voltage grids,synergies in widening countries,institutional innovation,regional innovation,widening countries
Multi-assessment of alternative fertilisers for promoting local sustainable value chains and clean ecosystems (FER-PLAY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Coordination and support actions
Countries involved: Spain,Italy,Belgium,Germany,Greece
Call: Environmental impacts and trade-offs of alternative fertilising products at global/local scale. (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2025-02-28
Duration (months): 30.0
Total project cost (EUR): 1999749.5
EU funding (EUR): 1999749.5
Participants: 16
Project status: CLOSED

Fertilisation is key to feeding the growing world population, yet the most common fertilisation scheme based on conventional fertilisers poses threats to the environment (e.g. eutrophication caused by nutrient leaching) and sustainability of the EU food system (due to high dependence on fertiliser imports from third countries). Thus, among the key EU political priorities is to reduce by 20% the use of conventional fertilisers by 2030 and to decrease nutrient losses by 50%. A promising solution for this aim are alternative fertilisers produced from recovered nutrients from secondary raw materials (e.g. bio-waste, sewage sludge). However, their wide scale deployment is hindered by lack of awareness about alternative fertilisation, concerns regarding their technical viability and the disparity of legislations that creates a state of uncertainty. In this context, FER-PLAY is a comprehensive approach to gather, harmonise, select and complement the knowledge on alternative fertiliser value chains and diffuse it to promote the wide-scale production and application of alternative fertilisers with best environmental, social and economic performance as well as technical and regulatory viability. Thus, FER-PLAY employs a unique methodology for mapping the value chains, select the most promising ones and assess their impacts. FER-PLAY engages key stakeholders in co-creation of results and broadly disseminates them. The consortium gathers key players from the whole value chain: (1) alternative fertiliser producers from all the main types of secondary raw materials (producers of digestate- 183 members, of compost- 120 members and of struvite), (2) entities representing conventional (1.5M members), organic (100,000 members) and young (200,000 members) farmers, (3) a Pan-European network with +100 members representing public administrations, supported by (4) waste valorisation and agriculture research institutes, (5) market strategists and (6) communication experts.

Keywords: alternative fertilisers value chains,conventional fertilisers,life cycle assessment,sewage sludge,bio waste,organic by products,wastewater
A Novel Framework for Contactless diagnosis and forecasting of Cardiovascular Diseases (ContactlessFramework)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

In ancient times, doctors have followed unorganized practices to diagnose cardiac arrest conditions of healthcare patients. The followed medical procedures were not very organized and accurate even though cardiac patients were diagnosed using devices, such as a stethoscope. However, the latest advancements in the technologies such as contactless remote patient monitoring, AIoMT (Artificial Intelligence of Medical Things), advanced big data and cloud-based analytics and alerts have created a paradigm shift in healthcare and provided 24 x 7 connectivity. The study proposed a VCardiac (Contactless Cardiac Classification and Risk Prediction) Framework to diagnose and identify early stages of heart diseases and forecast their cardiac conditions in advance using the human voice. In this study, a customized dataset termed "Cardiac-2000" with 2000 human voice samples will be designed to classify acoustic heartbeat events such as normal, murmur, extra systole, artifact, and other unlabeled heartbeat acoustic events. The average duration of the recorded heartbeat acoustic events would be 10 to 12 seconds. The primary reason for designing a customized dataset "cardiac-2000" is to balance the total number of samples into categories such as normal and abnormal heartbeat acoustic events. For performance evaluations of the proposed VCardiac Framework, the collected heartbeat acoustic samples will be classified using LSTM-CNN, RNN, LSTM, Bi-LSTM, CNN, K-means Clustering, and SVM methodologies. Furthermore, the proposed VCardiac Framework will also assist in classifying Age and Gender-wise risks using methodologies such as Kaplan-Meier and Cox-regression survival analysis. These methodologies will also assist in identifying the probability risk and the 10-year risk score prediction. In the end, the proposed VCardiac Framework will be tested for various Signal to Noise ratio conditions for achieving better accuracy, effectiveness, and throughput.

Keywords: contactless framework,cardiac arrest,cardiac detection,acoustic assistive framework,human speech based classification
Uncovering the molecular effects of the tubulin code and their impact on organism-wide functions (TubulinCode)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,United States,Czechia
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-05-01
End date: 2029-04-30
Duration (months): 72.0
Total project cost (EUR): 11319929.0
EU funding (EUR): 11319929.0
Participants: 4
Project status: SIGNED

Microtubules (MT) are core components of the eukaryotic cytoskeleton with essential roles in cell division, cell shape, intracellular transport, and motility. Despite their functional divergence, MTs have highly conserved structures made from almost identical molecular building blocks – tubulin proteins. A variety of posttranslational modifications (PTMs) diversifies these building blocks, which is thought to control most of the properties and functions of the MT cytoskeleton, a concept referred to as the ‘tubulin code’. While they appear to have subtle effects at the molecular level, tubulin PTMs are essential for maintaining cellular functions of MTs over large spatial and temporal scales. Yet, a comprehensive knowledge of the principles of the tubulin code, connecting its functions across the molecular, cellular and organismal levels, is almost entirely lacking. Our project aims to obtain a novel molecular and mechanistic understanding of how tubulin PTMs control long-term cellular function and homeostasis. Our unique approach bridges all relevant scales of biology and relies on a synergy between our powerful experimental models and expertise in biochemistry, structural biology, single-molecule assays, systems-biophysics, cell biology, and physiology. Specifically, we will: (1) Determine how different tubulin PTMs affect biophysical and structural properties of MTs and their interactions with associated proteins; (2) Define the impact of tubulin PTMs on overall MT cytoskeleton behaviour and the resulting physiological implications in neurons; (3) Combine zebrafish and mouse models and develop a novel fish model for lifelong in-vivo imaging to determine how the tubulin PTMs control lifelong MT-based functions. Our work will define the importance of tubulin PTMs by revealing their critical molecular functions over the lifetime of an organism. The project has the potential to substantially change our perception of the cytoskeleton’s role in homeostasis and disease.

Keywords: microtubule cytoskeleton,tubulin code,tubulin posttranslational modifications,axonal transport,neuronal homeostasis,zebrafish,mouse,danionella,in vivo imaging,motor proteins,in vitro reconstitution,cell mechanics
Eliminating onchocerciasis with Moxidectin in endemic hotspots of Central Africa (EMINENCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: United Kingdom,Congo,France,Cameroon
Call: Accelerating development and integration of therapeutics against Neglected Tropical Diseases (NTDs) in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 5205730.25
EU funding (EUR): 4986011.25
Participants: 5
Project status: SIGNED

Onchocerciasis is a neglected tropical disease leading to blindness and associated with epilepsy. Most cases are in sub-Saharan Africa. The WHO has proposed that its transmission be interrupted in a third of endemic countries by 2030. The main strategy is annual Community-Directed Treatment with Ivermectin (CDTI). Despite nearly 3 decades of CDTI, transmission persists in several foci. In Phase II & III clinical trials, moxidectin has shown superior efficacy compared to ivermectin, clearing Onchocerca volvulus microfilariae for nearly a year. No large-scale community trials have yet been undertaken to document its effectiveness and safety for mass treatment. A barrier to onchocerciasis elimination is its co-endemicity with loiasis in Central Africa. Individuals with high Loa loa microfilaraemia may develop serious adverse events if treated with ivermectin. EMINENCE will address these challenges through: 1) a Phase IIIb community trial of annual or biannual moxidectin compared to annual ivermectin in Bafia and Monatele, Cameroon, renowned for their high transmission intensity, 2) a Phase II adaptive trial of ascending moxidectin doses on increasing L. loa microfilarial densities, and 3) a social sciences study to assess the acceptability of and adherence to moxidectin. We will evaluate and model the epidemiological impact of annual or biannual moxidectin compared to annual ivermectin through parasitological, serological and entomological surveys, and will attempt to elucidate potential differences between the two drugs regarding their effects on adult worms. We will evaluate the safety, tolerability and efficacy of moxidectin compared to ivermectin in L. loa-infected individuals in the Republic of Congo and Cameroon. Our project will contribute to the evidence-base that moxidectin may be effective and cost-effective to accelerate onchocerciasis elimination in areas where ivermectin has proved insufficient, and will investigate its safety in loiasis co-endemic areas.

Keywords: onchocerciasis,persistent transmission,loiasis,co endemicity,moxidectin,ivermectin,phase iiib community trial,phase ii safety trial,acceptability,elimination,cameroon,republic of congo
Disruptive Economies and Macrolithic Technologies in the Euro-Mediterranean Bronze Age (CORNERSTONES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Spain,Czechia
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2498791.0
EU funding (EUR): 2498791.0
Participants: 3
Project status: SIGNED

Between 3000 and 1500 BCE, a relatively small number of Mediterranean and European societies underwent deep changes, leading to large-scale, centralised, and highly unequal economic and political entities. Most of these Early Bronze Age “innovative regions” are identified with the rise of a warrior elite or aristocracy, craft specialisation, agricultural intensification, and expanding exchange networks. What caused the rapid emergence and, centuries later, sudden collapse of these “disruptive societies” is one of history’s most important open questions, particularly in view of their triggering effect on the development of statehood beyond Ancient Mesopotamia and Egypt. CORNERSTONES will examine the economic factors underlying and connecting the rise and fall of Early Bronze Age disruptive societies by drawing on the heuristic potential of macrolithic tools. No artefact category of later prehistory was involved in a larger range of productive processes, from food processing to metal forging. Ubiquitous and plentiful, their numbers are directly related to production intensity, while their distribution reveals economic specialisation and centralisation. The limited attention so far paid to macrolithic tools in prehistoric archaeology is mainly due to the complexity of the required interdisciplinary approach. CORNERSTONES will meet this challenge with a set of innovative research tools from the fields of geology, material mechanics, functional analysis, ethnoarchaeology, and network analysis. New procedures and scientific standards will be combined in a comparative paleo-economic investigation of three of the most prominent Euro-Mediterranean Bronze Age contexts with disruptive trajectories: the Aegean Bronze Age, including Minoan Crete, the Únětice society in Central Europe, and El Argar in the western Mediterranean. This investigation is critical to the understanding of later disruptive processes and the economic challenges they represent for our own society.

Keywords: disruptive social dynamics,early state formation,euro mediterranean bronze age,palaeo economy,macrolithic tools
Training the next generation of research experts on dynamic X-ray imaging and smart emerging materials (X-CELERATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Germany,Czechia,Denmark,Slovenia,Netherlands,Hungary,Sweden,Italy
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-12-01
End date: 2029-11-30
Duration (months): 48.0
Total project cost (EUR): 3032590.68
EU funding (EUR): 2908930.68
Participants: 14
Project status: SIGNED

Additive Manufacturing has triggered a revolution in the fabrication and design of objects. However, traditional 3D printing methods remain limited in their ability to create dynamic structural components such as soft grippers, self-assembly systems, or smart actuators. This limitation initiated research and development of 4D printing, a technique which uses smart materials that are processed during 3D printing. Such materials possess properties that can be altered in a controlled and reversible manner in response to external stimuli such as temperature changes, magnetic fields, light, or exposure to chemicals. Despite the staggering potential of 4D printing adequate tools are lacking to dynamically study, inspect, and optimise smart materials. Recognizing the need for solution, X-CELERATE will focus on nurturing the next generation of innovators in the field of time-resolved, lab X-ray imaging, a rapidly evolving technology ideally suited to study the dynamics of smart materials. Challenges include the development of 1) targeted strategies for 4D X-ray computed tomography (4DCT) imaging, 2) 4DCT quality control methods, and 3) lab-based phase contrast imaging for low density smart materials characterisation. To address these challenges successfully, a multidisciplinary approach is required, incorporating expertise from diverse fields such as applied mathematics, physics, materials science, and product design. The primary goal of X-CELERATE is to develop novel 4DCT tools to boost the development and characterisation of advanced materials. By providing a comprehensive training environment, X-CELERATE aims to cultivate a new generation of research engineers with an entrepreneurial mindset who will play a crucial role in propelling Europe's manufacturing industry. X-CELERATE will realise a huge step towards harnessing the full potential of smart material applications, thereby paving the way for transformative advancements in Europe’s manufacturing industries.

Keywords: x ray imaging,additive manufacturing,4d printing,dynamic imaging,non destructive testing
Bottom-up chemical construction of photosynthetic cyanobacteria mimics and their controlled assembly into autonomous and self-regulating biofilm-like materials for hydrogen production (PROTO-BACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: TERMINATED

Broad interest is devoted nowadays to filling the breach between biology and chemistry in order to comprehend the frontier between living and non-living systems. In this context, protocells are autonomous and self-sustained entities fabricated from scratch, which may exhibit one or more characteristics of actual cells. This project aims at synthesizing cyanobacteria mimics capable of producing H2 and formaldehyde from visible light, water, and methanol. The active material for photosynthesis shall be a semiconducting heterojunction based on BiVO4 and Rh-doped SrTiO3-Pt for Z-scheme photocatalysis. The photocatalyst shall be contained within functional protein-polymer protocell membranes referred to as proteinosomes. These photosynthetic protocells will then be chemically programmed to self-assemble into the first autonomous and photosynthetic biofilm-like material (BFM). The careful three-dimensional design of the BFM, consisting in a combination of mechano-passive, mechano-active and photocatalytic layers of specialized proteinosomes, will allow an emergent and unprecedented photo-mechano-chemical transduction. Therefore, the BFM will be able of an autonomous and self-regulating behavior out of equilibrium. This proposal pushes forward the borders of bottom-up synthetic biology via a nice interdisciplinary interaction with semiconductor photochemistry. Furthermore, an alternative and sustainable route to the production of green fuels is provided, which brings an original solution to the current planetary energetic crisis.

Keywords: self regulation,photoactuators,soft robotics
Decellularised Extracellular Carpets for the Innovative Production of Human Engineered Replicates (DECIPHER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The major roadblock in the commercialisation of cell-derived products is the prolonged ex vivo culture period required to develop them. Macromolecular crowding (MMC), a biophysical phenomenon that increases the kinetics of biochemical reactions and biological processes by several orders of magnitude, allows for the accelerated development of cell-derived products. This project will exploit MMC in the development of cell-derived products in 2 technical and 3 commercial work-packages, increasing the international competitiveness of European-based biotech industries and creating new employment, markets and revenue. This 18-months interdisciplinary and intersectoral project will train 1 post-doctoral researcher at the forefront of scientific research and technological innovation. The project will be carried out at University College Dublin, Ireland’s largest university, one of Europe’s leading research-intensive universities and in the top 1 % universities world-wide.