Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative Solutions across the MEDiterranean for mitigation of Climate change-related heaLth rIsks and enhancing health systeM resilience (ISMED-CLIM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Cyprus,Greece,Italy,Spain,Portugal,United Kingdom,United States,Belgium,Estonia,Switzerland,Serbia
Call: Testing and demonstrating transformative solutions to build resilience towards health risks caused by the effects of climate change (HORIZON-MISS-2023-CLIMA-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 6345902.5
EU funding (EUR): 5999552.0
Participants: 28
Project status: SIGNED

ISMED-CLIM aims to engage and mobilise regional stakeholders across the Mediterranean, in implementing a wide array of adaptation solutions to mitigate the health effects of climate change, and provide evidence for their feasibility, user acceptance and efficacy. Specifically, ISMED-CLIM will (i) enhance the understanding of climate change effects on non-communicable diseases (NCDs) and vector-borne infections across representative European countries within the Mediterranean; (ii) quantify, for the first time, how public health interventions integrating state-of-the-art technologies, public and social media, with vulnerable citizens’ participation can reduce personal exposures to heat and air pollution and related health effects; (iii) validate the feasibility and user acceptance among high risk professionals of a regional early warning and risk prediction tool to mitigate the risk posed by exposure to sand flies and related diseases; (iv) employ open, participatory, and co-creative methodologies to locally adapt and refine existing evidence-based practices and prototype tools to increase the preparedness and ability of health systems in the Mediterranean to deliver safe, effective, and efficient care to citizens. We will test the proposed demonstration solutions initially in eight sites and coordinate ten replications in six sites in five European countries (Cyprus, Greece, Italy, Spain, Portugal), in alignment with Climate Change Adaptation Mission objectives. We will integrate the produced knowledge from epidemiology, forecasting, exposure and health data with insights from the demonstration and replication activities into a knowledge portal and policy decision-centric and action-oriented dashboard for policy makers, healthcare administrators, professionals and citizens. ISMED-CLIM’s approaches will be readily applicable in other European regions affected by the same or other climate change-related stressors, such as forest fire smoke, floods, ozone, and cold.
Passive Solar Evaporators for Green Desalination Technologies (SEAFRONT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2026-09-30
Duration (months): 47.0
Total project cost (EUR): 278571.36
EU funding (EUR): 278571.36
Participants: 2
Project status: SIGNED

Clean freshwater is an essential ingredient for healthy human life. However, over 1.1 billion people worldwide lack access to freshwater. With our already depleted natural freshwater resources and push towards climate neutrality, outlined by the UN’s Sustainable Development Goals, there is significant stress on the world’s water purification technologies. Capillary-driven solar evaporation provides a very promising basis for the development of cost-effective, deployable, and eco-friendly freshwater solutions to deal with this pressing global challenge. Solar evaporation is energy intensive, however, and the contamination of the capillary structures can block fluid pathways, leading to a low water yield. The concept of exploiting hydrogels as capillary-driven evaporators (CDE) in carbon-free solar desalination offers the exciting prospect of high efficiencies, cost-effective materials, and longevity. However, the transport characteristics, thermo-fluidic behaviour, and in situ structural dynamics that affect freshwater generation, are not properly understood. This project aims to develop and demonstrate high-efficiency passive solar-water desalination devices by gaining an in-situ non-invasive insight into the underlying physics of hydrogel CDEs using x-ray inspection (XRI). Prof. Evelyn N. Wang’s research lab at MIT (Device Research Laboratory, DRL) is a global leader in nanoscale transport phenomena, materials chemistry, and converting nanoscale to the device-level. The DRL will train me in these areas, and provide facilities for fabrication, XRI, and device-level solar-water simulation. During the outgoing phase, I will be incorporated into MIT’s training environment, thereby enabling my personal growth and career development, understanding of climate challenges, and awareness of diversity issues. On return to the Bernal Institute, I hope to establish myself as a leading investigator in the clean water sector, creating a new research group within Europe.

Keywords: desalination,clean water,renewable energy sources,solar evaporation,capillary driven evaporation,porous media,hydrogels,water scarcity,sustainable design
First modular, interconnected, data- and AI-driven software platform for the digitisation of patient care in the healthcare industry (Digitising Hospitals For Better Patient Care)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 3558750.0
EU funding (EUR): 2491125.0
Participants: 1
Project status: CLOSED

In Europe, there are 36.6 doctors and 83.3 nurses per 10,000 inhabitants. Both professional groups spend 169 minutes of their working time every day on administrative tasks as patient care is not properly digitized. With our modular platform, we offer the first plug & play solution to digitise the entire patient documentation & treatment process while simultaneously automatically generating fully structured medical data. It is the first holistic approach that networks all hospital departments, connecting more than 40 operable applications. On the basis of the unique structured data, we develop a workflow engine that fully optimises and automates the treatment process as well as an AI-based diagnostic support system that assists doctors and nurses in diagnosis and treatment. Our software saves up to 10 minutes on administrative tasks per patient treatment and drastically improves the quality of care.

Keywords: artificial intelligence,electronic health record,patient health record,ehealth,machine learning,statistical data processing,digital services,digital health
SST & STM system architecture and evolutions. Horizon Europe TOP2 (HE23-24 TOP2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Research and Innovation actions
Countries involved: Spain,France,Poland,Germany
Call: SST & STM system architecture and evolutions (HORIZON-CL4-2025-SSA-SST-IBA, 2025)
Start date: 2026-01-01
End date: 2028-06-30
Duration (months): 30.0
Total project cost (EUR): 6000000.0
EU funding (EUR): 6000000.0
Participants: 4
Project status: SIGNED

SST & STM system architecture and evolutions The specific objectives of the HE_EUSST_MS_TOP2 action have been defined considering the specific objectives defined in the Work Programme: • Foster European cooperation in the SST domain and improve the EUSST performance towards larger autonomy. • Highlight and propose solutions to fill the gaps in the current EUSST architecture. • Pave the way on which the EUSST system has to evolve towards a higher level of performance (e.g. accuracy; number / size of catalogued objects...), quality of service (e.g. timeliness of information...) and autonomy. • Demonstrate the complementarity, coherence and added-value of each element of EUSST system towards a more autonomous, interoperable SST system. Explore and look for higher levels of cooperation with other SST systems such as the US SSA system which is of paramount importance to develop long-term cooperation. • Raise the main issues and propose relevant answers to questions posed by all those developments in various technical and operational domains based on the outcome of the previous STM coordination and support actions developed under H2020. • Propose adaptation to the new changes, and solutions for their possible integration into the existing standards, practices and technological means. The state of the art on the topic can be summarized as the current activities carried out in project 2_3SST2018-20 and the current grants under HE.

Keywords: eusst,sst,partnership,services,assets,sensors,radars,telescopes,catalogue,collision avoidance,re entry,fragmentation,survey,tracking,autonomy
Experimental assessment of wildlife viruses emergence potential through systematic characterization of human cell tropism (EmerVir)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-15
End date: 2025-11-14
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Emerging viruses pose a tremendous threat to human health and economy, as dramatically shown by the ongoing COVID-19 pandemic. Most emerging viruses are zoonotic, meaning that they can be transmitted between animal species and humans. Although it was estimated that more than one million viral species exist in the two main reservoirs of zoonotic viruses (mammals and birds), only a few hundred are known to infect humans. This means that the majority of wildlife viral species will likely not cause major outbreaks in the human population, but that many potentially human-infective viruses are lurking in nature. Although large-scale metagenomic studies allowed the identification of thousands of new viral species, functional data, including their ability to infect human cells, are often missing. Previous work has examined the human cell tropism of a fraction of wildlife viruses, but no systematic analysis of the factors involved in viral entry has been undertaken. In this proposal, we will use synthetic biology, experimental virology and viral evolution using a large number of human cell lines to implement a high throughput characterization of wildlife viruses' tropism. We will first test whether wildlife viruses’ envelopes from diverse viral families can mediate infection of a large panel of human cell lines. Comparing available transcriptomic data of susceptible and non-susceptible cell lines, we will identify novel wildlife viruses’ host entry factors. Finally, using experimental evolution, we will investigate how viral envelope natural selection and diversification impact the use of these newly identified entry determinants. Overall, this project should improve epidemic preparedness by identifying viral species or variants at higher risk to infect humans, as well as host factors participating to viral entry, which are potential targets for the development of antivirals.

Keywords: virus evolution zoonosis emergent diseases experimental evolution viral tropism pseudovirus viral receptors host entry factors vesicular stomatitis virus
Enhancing efficiency and safety in operating rooms VitVio's AI-Powered Platform: Redefining hospital efficiency in European hospitals, minimising errors and maximising patient care standards (AI-powered hospitals)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1099158.0
EU funding (EUR): 1099158.0
Participants: 1
Project status: SIGNED

VitVio, is seeking funding from the EIC Accelerator Fund to improve hospital care in the face of the consistent rise in healthcare costs across Europe, with inefficiencies costing hospitals ~€229.5B annually. Patients in the EU can experience wait times of 50-650 days for routine procedures, suffer from not receiving care on time, and are being marginalised and excluded from the workforce. VitVio aims to tackle these inefficiencies and increase productivity across hospital operating blocks through its autonomous platform, powered by computer vision, tool and surgery tracking, helping in performing 5 more surgeries per month per operating room. Website: https://www.vitvio.com/

Keywords: surgery progress monitor,computer vision,ai powered runway estimates,surgical efficiency,tool tracking,data anonymisation,or utilization,patient safety,turnaround,operating room automation
Decoding Monocyte Metabolism in Myocardial Infarction: A Time-Sensitive Approach to Limiting Heart Failure (3MI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

Cardiovascular diseases (CVD), particularly myocardial infarction (MI), are partly driven by chronic inflammation, in which myeloid cells, such as monocytes and macrophages, play a central role. This project aims to elucidate the metabolic mechanisms regulating monocyte function and their impact on post-MI recovery. Emerging evidence suggests that the metabolic state of myeloid progenitor cells and their descendants critically influences their pro- or anti-inflammatory functions. While glycolysis dominates early after MI, fatty acid oxidation takes over later stages, indicating that metabolic reprogramming is essential for monocyte and macrophage function. In this project, we will investigate the metabolic signatures of monocytes at different time points post-MI using a preclinical mouse model and the human HIBISCUS STEMI cohort. We aim to identify key metabolic pathways that can be targeted to modulate inflammation by employing single-cell RNA sequencing and single-cell metabolic assays. In mouse models, we will further test the effects of transiently inhibiting glycolysis or fatty acid oxidation in monocytes, using genetically modified mice, to determine whether this approach improves cardiac function and limits heart failure. Additionally, the fellowship will provide essential soft skills training in project management, mentoring, and grant writing, which are crucial for my transition to an independent research position. These skills will enhance my leadership abilities and prepare me for future academic and industrial opportunities. This research will provide new insights into the role of metabolism in myelopoiesis and inflammation and could lead to novel therapeutic strategies to improve outcomes in CVD patients.

Keywords: myocardial infarction,heart failure,monocytes
Sustainable agriculture through novel pesticides using an integrated approach (SAGROPIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Austria,Netherlands,Denmark,Portugal,United States,Spain,Germany,France,Switzerland
Call: Innovations in plant protection: alternatives to reduce the use of pesticides focusing on candidates for substitution (HORIZON-CL6-2023-FARM2FORK-01, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 6579896.25
EU funding (EUR): 5996694.01
Participants: 11
Project status: SIGNED

Safe and secure food production is central to the European Farm to Fork policy. However, secure crop production still depends on the widespread use of chemical pesticides, which is associated with negative impacts on the environment and human health. Diminishing use of so-called ‘candidates for substitution’ identified in Regulation (EC) No 1107/2009 is of particular importance for combating harmful effects. SAGROPIA employs integrated pest management (IPM) to demonstrate substitution and reduction of chemical pesticides in the cultivation of potato and sugar beet. These row crops are prone to diseases such as early and late blight and cercospora leaf spot and to pests such as nematodes and the Colorado beetle. SAGROPIA will bring forward thirteen biological and low-risk pesticides from three company partners with the aim to replace several ‘candidates for substitution’ active substances , including the nematicide oxamyl and the fungicides difenoconazole, fluopicolide and metalaxyl. It also aims to reduce overall use of ‘candidates for substitution’ copper and insecticides pirimicarb, lambda-cyhalothrin and esfenvalerate by at least 50%. SAGROPIA’s approach combines several biocontrol solutions that, individually, have already proven activity on specialty crops and are close to market. SAGROPIA solutions are formulated, production is upscaled, and their mode of action is being studied. To grant affordability and ready acceptance by farmers, SAGROPIA envisions not simple replacement of chemical pesticides but incorporation of its solutions into innovative, comprehensive IPM strategies. Effectiveness will be demonstrated in participatory real life-trials performed in five potato and sugar beet growing European regions with active participation and engagement of farmers. Thorough sustainability assessments will give account of economic feasibility and show improved performance in terms of natural resources, people and the environment, besides preparing novel solutions.

Keywords: potato,sugar beet,sustainability assessment,chemical pesticide reduction,early and late blight,cercospora leaf spot,colorado beetle
Elucidating the Evolution of Endothermy through an Endolymphomics Approach (ENDOMICS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 1
Project status: SIGNED

Endothermy, the ability to maintain a stable internal body temperature, is a key evolutionary steppingstone that allows animals to thrive in diverse environments, sustain high activity levels, and achieve greater reproductive success despite increased energy demands. This thermoregulatory strategy has led to complex behaviors and evolutionary innovations, enabling endothermic animals, like birds and mammals, to dominate ecosystems throughout time. However, the origins of endothermy remain hotly debated. The ENDOMICS project aims to contribute to this debate by exploring the evolution of endothermy through advanced metabolomics and proteomics analyses of endolymph across various species. Endolymph, a fluid in the inner ear that monitors head movements and allows hearing, appears to vary in viscosity between taxa, detrimentally impacting ear biomechanics. By studying the proteins and metabolites in endolymph, we can understand the factors behind these variations. For instance, birds seem to have adapted to higher body temperatures by altering the chemical composition of endolymph, increasing its viscosity. We hypothesize this change to be linked to augmented presence of proteins/metabolites, known to increase biofluids’ viscosity, offering a cornerstone piece of information for understanding the onset and evolution of endothermy. ENDOMICS trailblazes the study of variation in the composition of endolymph across taxa. Our findings will clarify the fossil record, providing a deeper understanding of extinct species' biology by estimating their physicochemical properties from living counterparts. The study's results also have broad implications, including informing climate change adaptation, advancing treatments for hearing/balance disorders, and fostering innovation in synthetic biology, particularly with synthetic endolymph. As the global population ages, this research will be increasingly important in addressing the growing incidence of hearing impairments.

Keywords: tetrapod paleontology vestibular system physiology thermo motility index tmi endothermy evolution dinosaur bird lineage endolymph proteomics and metabolomics