Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of technologies in an energy efficient economy – model-based analysis of policy measures and transformation pathways to a sustainable energy system (REEEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Finland,Croatia,Lithuania,Sweden,Netherlands,Denmark,Denmark,United Kingdom,Faroe Islands
Call: Modelling and analysing the energy system, its transformation and impacts (H2020-LCE-2015-2, 2015)
Start date: 2016-02-01
End date: 2019-07-31
Duration (months): 42.0
Total project cost (EUR): 3997458.75
EU funding (EUR): 3997458.75
Participants: 11
Project status: CLOSED

REEEM aims to gain a clear and comprehensive understanding of the system-wide implications of energy strategies in support of transitions to a competitive low-carbon EU society. Comprehensive technology impact assessments will target the full integration from demand to supply and from the individual to the entire system. It will further address its trade-offs across society, environment and economy along the whole transition pathway. The strong integration of stakeholder involvement will be a key aspect of the proposal. The assessments performed within REEEM will focus on integrated pathways, which will be clustered and categorised around two focal points: the four integrated challenges of the Integrated Roadmap of the Strategic Energy Technology (SET)-Plan and the five dimensions of the Energy Union. Case studies will further serve to investigate details and highlight issues that cannot be resolved at a European level. A range of outputs will target the specific needs of various stakeholder groups and serve to broaden the knowledge base. These include, among others, Policy Briefs, Integrated Impact Reports, Case Study reports and Focus Reports on economy, society and environment. A focus on technology research, development and innovation will be included through the development of Technology Roadmaps with assessments of the Innovation Readiness Level of technologies. Further, a set of enabling tools will help to disseminate and actively engage stakeholders, including a Stakeholder Interaction Portal, a Pathways Diagnostic Tool and an Energy System Learning Simulation. Access to all work developed and transparency in the process will be guiding principles within this project exhibited by, for example, providing open access to a Pathways Database.

Keywords: energy systems modelling,economic,societal and environmental impact assessments,stakeholder engagement,set plan
Conexbird Wind speed up containers and prevent damages (CB Container SpeedUp)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Finland
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Conexbird has created patented system to revolutionize containerized cargo industry’s efficiency and security into a whole new level. During the container handling, like lifting, the Conexbird Wind system inspect the container and cargo condition automatically using vibration technology. This will speed up the container handling process, prevent cargo damages, reduce empty container transport and alarm criminal actions. When Conexbird Wind system is adapted into the container handling process we are able to save 1-2 lifts per transport. This means 10% - 20% savings in costs and emissions. Showing the changes in cargo, like loosen lashing and container damages, can prevent 10%-15% of the cargo damages. Taking the empty container inspection from container depots to the unloading or stuffing points will cut the ground transport of empty containers to half. This saves 20% of all container transports costs and emissions in inland. During the phase I the details are planned to adapt the Conexbird Wind to the different stakeholder’s processes. Also the representatives of the end user groups are selected for the pilot project as well as the sales and installation/maintenance channels. During the phase II of this project we will build a pilot where the Conexbird Wind system is adapted in the existing container handling processes in selected routes. This will be done together with the selected stakeholders. We need to be able to work together with port operators, container depots, container owners, cargo owners, freight forwarders, insurance companies and customs. The objectives of the overall project are a significant cost and emission savings in container shipping industry. At the same time one more global company is raising in Europe. Conexbird will charge on average 1 € per container or cargo condition data. In three years from the pilot project we seek 10% share of the global container handlings meaning 100 Million sold inspections and 100 Million euro revenue per year.

Keywords: shipping container inspection,cargo security,prevent cargo damages,reduce co2 emissions,faster flow of containers,internet of things,big data,cleantech
Next generation, high performance, long range, standoff, concealed threat detection system to protect European citizens and critical infrastructure (MiRTLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Poland,United Kingdom
Call: Engaging SMEs in security research and development (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-10-01
End date: 2020-10-31
Duration (months): 25.0
Total project cost (EUR): 1345725.0
EU funding (EUR): 942007.51
Participants: 2
Project status: CLOSED

Acts of terrorism aim to instil fear into Europe's citizens. Since 2000, approximately 163,000 people have died from global terrorism. In particular, attacks against citizens and urban soft targets have increased as terrorists exploit the ability of autonomous cells and lone individuals to hit civilian targets such as concerts, markets, shopping malls, airports, transport hubs, sports stadia, cinemas, bars, night clubs and tourist resorts. Recent devastating attacks across Europe clearly illustrate the increasing threat that exists. It is impossible to deploy security personnel in sufficient numbers to protect every location. Even if security personnel are present they currently lack the technology to detect, at a safe range, concealed threats such as person borne improvised explosive devices (PBIEDs), guns and knives. There is an urgent and growing need for a cost effective, high performance, long range, concealed threat detection system. Radio Physics Solutions Ltd has developed MiRTLE (Millimetre-wave Radar Threat Level Evaluation), the world’s first, high performance, long range (up to 50m), low cost, standoff “concealed threat” detection system for the protection of citizens and critical infrastructure. MiRTLE is capable of screening large groups of people automatically and autonomously, without operator intervention, in real-time. Our highly innovative system detects PBIEDs, guns (including 3D printed) and knives up to a range of 50m in real-time, with targets in motion, all without privacy concerns. The overall objective of this project is to successfully refine, scale-up and demonstrate our superior technology to our customer base. We are planning to capture an 8% market share of the improvised explosive devices (IED) and weapon detection market, which will in turn generate cumulative revenues of €161m, cumulative EBITDA of €43m by 2025 and create 302 high skilled jobs in Europe.

Keywords: threat detection,pbied,explosives,bombs,terrorist,guns,weapon,gun related crime,radar,millimeter wave,3d printed guns,security,urban soft targets,critical infrastructure
Bioinspired Nanostructures by Self-assembly of Amphiphilic Non-peptide Helical Foldamers in Aqueous Environment (FOLDASYNBIO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The design and precise construction of biomimetic self-assembling systems in aqueous solution is a challenging yet potentially highly rewarding endeavor, contributing to the development of new biomaterials, catalysts, drug-delivery systems and tools for the manipulation of biological processes. A high level of sophistication with control over morphologies and functions has been achieved by engineering self-assembling peptide-based building units. Although peptides possess a number of specific advantages including synthetic availability, modularity, one difficulty resides in precisely controlling the rules relating primary sequence and secondary structure. Alternatively, opportunities exist to develop bottom-up approaches using non-natural oligomers also referred to as foldamers, with predictable and well-defined folding patterns. Advances in foldamer chemistry bode well for their use as building units for the precise construction of nanometer scale assemblies and for possible applications. This project will move a step forward towards the realization of this mission, by developing protein-like quaternary arrangements under sequence based control using amphiphilic helical foldamers in aqueous conditions. The applicant has been trained in the synthesis of folded oligoamides and more importantly has acquired a high level of expertise in the design and structural characterization of peptide-based assemblies. He will join and bring his expertise to a host laboratory in France that has pioneered the development of urea-based helical foldamers. Secondment in one established European group with prominent expertise in X-ray crystallography techniques and biological structure determination will provide the appropriate combination of knowledge required for this multidisciplinary study. This approach will be a milestone in the design of foldamer-based quaternary architectures and may lead to new functional nanostructures.

Keywords: foldamers,nanostructures,helical bundles,peptidomimetics,self assembly
Textuality, Place, and the Self: Reimagining Life Writing through Women’s Diaries from Ireland, 1725-1810 (DIARIES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-12-11
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

DIARIES will enable the experienced researcher, Dr Amy Prendergast (AP) to undertake a 24-month fellowship – Textuality, Place, and the Self: Reimagining Life Writing through Women’s Diaries from Ireland, 1725-1810 – at Queen’s University Belfast, under the supervision of Professor Moyra Haslett, an expert in eighteenth-century Irish and women’s writing. Engaging with overlooked archival diaries by women across Ireland, DIARIES will reconceptualise the diary form and reinvigorate international concepts of the diurnal self, transforming the field of life writing, and contributing to groundbreaking findings for Eighteenth-Century Studies. Incorporating methodologies and approaches from multiple disciplines, the project will allow high-impact dissemination, forming the basis of AP’s second monograph, an international interdisciplinary conference, a peer-reviewed journal article, and a website. Exploring the creative potentials of exchange between university and practitioner organisations, DIARIES will allow for the reimagining of Ireland’s literary and cultural heritage in both Northern Ireland and Republic of Ireland, advancing and enhancing understanding of both the 18c and women’s lives. This period of mobility will see AP learn new research-specific skills; continue her professional development; and gain research-relevant inter-sectoral experience through a prestigious secondment at the National Trust. The pioneering research generated will be innovatively disseminated for diverse audiences within and beyond the academy, embedding knowledge through workshops, an exhibition, teaching and collaboration, and cross-border outreach events. DIARIES will augment and advance AP’s international reputation as a leading scholar of 18c writing and an emerging expert in life writing, enabling her to realise her outstanding potential, and positioning her to secure a permanent lectureship in a prominent European University.

Keywords: life writing,women s writing,eighteenth century writing,irish literature,paratext,archives
COMAL:COhesin Mutations in Acute Leukemia: from modeling and mechanisms to novel therapeutics (COMAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1999574.0
EU funding (EUR): 1999574.0
Participants: 1
Project status: CLOSED

Transcriptional dyregulation is a common driver in cancer and acute myeloid leukemia (AML) is an exemplar of this process. AML has a dismal survival rate of <30% with novel targeted therapies urgently required. My research focuses on improving our understanding of the biology of AML and using this knowledge to develop targeted therapies to improve outcomes. Recently loss-of-function mutations in members of the cohesin complex have been described in up to 15% of patients with AML. The cohesin complex mediates sister chromatid cohesion, an important process for DNA repair and proper chromosomal segregation. It has also recently been demonstrated to be important for transcriptional regulation, due to its coordination of communication between promoters and enhancer and insulator elements. Evidence suggests that transcriptional alterations underlie the mechanisms of transformation by cohesin mutations in AML. However, other evidence and my preliminary data also suggest cohesin mutant cells to have specific vulnerabilities related to their roles in proper chromosome segregation and DNA repair that can be specifically targeted. Objectives: 1) Generation of mouse models of cohesin-mutated AML. To model AML in vivo and as a resources for Obj 2-4 2) Characterisation of transcriptional defects in cohesin-mutated AML using state-of-the-art genomic techniques (RNA-Seq, ChIP-Seq and Capture Hi-C) 3) Define mechanisms of cohesin-mediated transcriptional regulation in normal hematopoiesis and its alteration in leukaemia using SILAC based proteomics and ChIP-Seq co-binding 4) Therapeutic targeting of the cohesin complex in cohesin-mutant AML using compounds identified in a large screen and suggested by Obj 1-3 and tested in cell lines, patient samples and in vivo models. This proposal will inform mechanisms of transcriptional regulation that occur during normal hematopoiesis and how these are altered in AML. It will also identify candidate therapies for this aggressive disease

Keywords: mechanisms of leukemia,mouse models of leukemia,repositioned therapies,personalised therapy
Genetic regulation and functional relevance of maize starchy endosperm programmed cell death (END-osperm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: TERMINATED

Around 60% of our daily diet is directly derived from cereal grains. In the grain, most nutrients are stored in a highly specialized reserve tissue called the starchy endosperm (SE). SE development ends by the execution of a controlled cell death program (PCD), which leaves the nutrient-filled cell corpses largely intact. PCD has been proposed to be crucial for storage compound preservation, but despite this potential importance, surprisingly little is known on the genetic regulation of SE PCD. In this project, I hypothesise that cereal SE PCD is controlled by a gene regulatory network that I propose to investigate in maize (Zea mays). To this end, I will combine the extensive knowledge I acquired during my PhD on maize kernel development with the well-documented expertise of the host lab in plant PCD analysis. I will first determine the spatio-temporal pattern of SE PCD under the growth conditions of the host institute and characterise its subcellular features in detail by ultrastructural analyses. As SE PCD is not executed homogenously in time and space, I propose to perform then a single-nucleus RNA-seq combined with a spatial transcriptomics approach on dissected endosperm tissue in order to obtain transcriptome profiles and developmental trajectories with single-cell resolution. Based on their expression profiles, I will finally select up to 20 PCD-associated candidate transcription factors and screen them for gain-of-function PCD phenotypes in transient expression systems. Promising candidates will be functionally analysed in maize SE via gain- and loss-of-function approaches. In the resulting maize lines, I will investigate the changes in PCD progression and use them to assess the physiological relevance of a correct PCD execution in the SE. In sum, this project will generate the first functional insights on the gene regulatory networks of cereal SE PCD and will provide new leads for future agronomic applications.

Keywords: endosperm,programmed cell death,seed,grain,maize
Towards the Bottom of the Periodic Table (TOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: CLOSED

Actinide and lanthanide chemistry is currently experiencing a renaissance, due to the prospects of obtaining novel materials relevant for applications in chemical synthesis, electronics, materials science, nanotechnology, biology and medicine. Most of the fascinating properties of the lanthanide and actinide materials are related to the partially filled 4f/5f valence shell and in contrast to the rest of the periodic table, are poorly understood. This includes the surprising reactivity, magnetic and crystal structure properties and, the rather unpredictable, covalent or ionic nature of their bonds. It is now possible to study the chemistry of the f-block elements using state-of-the-art techniques that were not available before. Two new synchrotron-based techniques, high energy resolution fluorescence detection (HERFD) X-ray absorption spectroscopy and resonant inelastic X-ray scattering (RIXS), can now provide unprecedented detailed information on processes such as the electron-electron interactions, hybridization between molecular orbitals, the nature of their chemical bonding, and the occupation and the degree of the f-electron localization. Therefore, I propose to apply these cutting-edge techniques to advance the fundamental understanding of the lanthanide and actinide nanoparticles, an outstanding problem in materials science, chemistry and environmental science technology. The research will be conducted at the European Synchrotron (ESRF), at the Rossendorf Beamline (ROBL) dedicated to actinide science, where we recently installed a novel X-ray emission spectrometer with ground-breaking detection limits. The experimental work will be complemented by electronic structure calculations. The combined experimental and theoretical data will provide an essential knowledge of lanthanide and actinide chemistry, significant for topics of high societal relevance, like green chemistry, renewable energy and catalysis.

Keywords: f electron systems,lanthanide,actinide,herfd,rixs,nanoparticles
Pupiloscope, a Neuro-Critical Care Device, Enabling Quantitative, Real-Time, Pupillary Monitoring and Assessment of Patients with Neurotrauma and Head Injuries. (PUPILOSCOPE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2021-09-30
Duration (months): 40.0
Total project cost (EUR): 1250911.25
EU funding (EUR): 875637.88
Participants: 1
Project status: CLOSED

An estimated 42 million people Worldwide suffer a Head Injury (2.5 million in the EU) that can lead to Mild or Traumatic Brain Injury (TBI). It is a major cause of death and disability, especially in young people, impacting victims and relatives, with significant costs to society, estimated at €33 Billion per annum in Europe alone. Pre-Hospital and Emergency Care Neuro-Monitoring, including pupillary assessment, is critical in the processes of triage, management and medicating patients to prevent secondary injury to the brain. However, the current method of shining a light into a patient's eyes, in order to estimate pupillary response, is subjective and prone to human error. The solution is Pupiloscope®, enabling Accurate, Real-time, Quantitative Pupillary Monitoring and Assessment for patients with potentially life threatening head injuries. Pupiloscope is a breakthrough technology that will positively impact clinical pathways as well as patient outcomes. It is quick, simple, and easy to use by Doctors, Nurses and Paramedics of all skill levels. Through collaboration with industry experts, key opinion leaders, engineers and Emergency Care based clinicians, who identified the unmet clinical need, ViVO has successfully developed a functional prototype to TRL 6. As a direct result of this project, Pupiloscope forecasts sales of €20 Million within 5 years of product launch, improving patient outcomes and reducing both the societal and costs of care in the EU and Globally by an estimated €2 Billion per annum. This project will seek to develop Pupiloscope into a clinically proven, manufacturing ready and CE approved medical device; incorporating technology finalisation, regulatory approval, health economics, clinical testing and validation, therefore enabling product launch and sales to the EU and Global Emergency Care healthcare markets.

Keywords: pupillary assessment,neuromonitoring,patient,pupil,neurotrauma,head injury,patient care,monitoring