Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Measuring Irregular Migration and related Policies (MIrreM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Coordination and support actions
Countries involved: Austria,Italy,Germany,Netherlands,Finland,Spain,Greece,Belgium,Poland,Canada,United Kingdom,Portugal
Call: Estimates of irregular migrants in Europe - stakeholder network (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2788250.0
EU funding (EUR): 2788250.0
Participants: 18
Project status: SIGNED

Targeted policy responses for irregular migration require better knowledge about the characteristics of the irregular migrant population and dynamics of irregular migration, as well as about the effects of policy measures. Yet, quantitative data relating to irregular migration are scarce, often outdated and contested. The inadequecy of current data makes it challenging for stakeholders to develop and monitor policies. How do legal frameworks in different countries define migrant irregularity? What are the characteristics of irregular migrants in terms of age, gender, nationality or other socioeconomic variables? How can the effects of policy measures, such as regularisation, be assessed? MIrreM adresses the challenge of insufficent knowledge about irregular migration and regularisation in Europe by actively involving relevant stakeholders in every stage of this project – as co-creators of its results and as stakeholders to its mission. In a rigorous comparative and multi-level study, we will assess the policies, data needs and estimates that define migrant irregularity in 11 EU member states, the UK, Canada, the USA and five transit countries. Using several coordinated pilots we will develop new and innovative methods for measuring irregular migration and ‘regularisation scenarios’, and we will explore if and how these instruments can be transferred or scaled up to other socio-economic or institutional conditions. Based on these insights, we will develop two public databases: a) a database with estimates on irregular migrant stocks and b) a database on irregular migration flows, that will also include data on regularisations. Together with the expert groups, we will synthesize our findings into a Handbook on data on irregular migration and a Handbook on regularisation that will support evidenced-based and targeted policymaking concerning irregular migration. Finally, we will develop training resources for policymakers, practitioners, journalists and early-career researchers.

Keywords: irregular migration regularisation migration management
C- and N-terminal Epitope Conjugate immune Cell Targeted Vaccines (CNECT-VAX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

CNECT-VAX will validate the technical and commercial feasibility of a new cancer vaccine platform that uses nanobodies targeting dendritic cells to co-deliver antigens in vivo. As of 2019, cancer affects over 19 million people worldwide and results in almost 10 million death annually, however, the treatment of patients remains a challenge. Immunotherapy options including dendritic cell (DC) based vaccines have become available, but the clinical efficacy of such treatment remains very modest and restricted to patient subsets. To overcome the limitations in the current state-of-art solutions and break barriers to achieve higher clinical efficacy, Dr. Martijn Verdoes proposes a novel molecular vaccine strategy that effectively delivers target antigens to DCs in vivo in the patient to concomitantly induce robust synergistic CD4+ and CD8+ T cell responses. The technical feasibility of CNECT-VAX will be assessed both in vitro and in vivo, using monocyte-derived human dendritic cells (MoDC) and a mouse model containing humanized DCs respectively. In both systems, the functionality of DCs and the consequent T cell activation and immune responses will be measured. Subsequently, commercial feasibility will be determined by verifying IP position and strategy, performing in-depth market and competitor analyses, and finally consolidating these into a business plan to establish the best path to commercialization. Successful commercialization of CNECT-VAX could reduce the profound socioeconomic burden of cancer, extend and improve the lives of patients, provide the pharmaceutical industry with further collaborative opportunities, and stimulate further scientific research based on this platform to treat other pathogenic diseases.
Optimal Cosmological Analysis at the Pixel level (OCAPi)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1499913.0
EU funding (EUR): 1499913.0
Participants: 1
Project status: SIGNED

Distorted by the gravity of cosmic structures, galaxy shapes can answer the biggest questions in cosmology: How do cosmic structures form? What is the nature of dark energy and dark matter? While the cosmological model succeeds at explaining a wide range of observations, it relies on two components whose nature remains unknown: dark matter and dark energy. Moreover, weak lensing surveys have found that the Universe is more homogeneous than expected from the cosmic microwave background, indicating a tension between observations. Resolving this tension and understanding the dark components of the Universe are the most pressing challenges of cosmology today. The Euclid mission and the Rubin Observatory will observe the positions and shapes of billions of galaxies with unprecedented precision. These data have the potential to revolutionise our understanding of dark energy and detect deviations from the cosmological model. However, standard analyses discard large amounts of information in the data. To realise the full potential of these surveys, we urgently need more advanced data analysis techniques. The OCAPi project will develop cutting-edge methods to make optimal use of these surveys, delivering the most precise constraints on the cosmological parameters from Euclid data. By analysing lensing maps at the pixel level, OCAPi will capture all the information in the data and increase the precision of the cosmological constraints, yielding marginal errors up to a factor 5 better than standard techniques. OCAPi will move this innovative approach from its proof-of-concept to the full application to Euclid data to investigate the cosmology tension, constrain dark energy models and generate probabilistic mass maps of the Universe. Making optimal use of one of the most powerful cosmological datasets, OCAPi will advance our understanding of the dark components of the Universe and the formation of cosmic structures, setting new benchmarks for cosmological analysis.

Keywords: field level analysis,euclid,high order statistics,mass mapping
The Politics of Citizen Opposition to Urban Development (POLICITY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1455684.0
EU funding (EUR): 1455684.0
Participants: 1
Project status: SIGNED

A central conflict in urban politics lie between those who want cities to change, physically, by embracing ambitious urban development projects, and urban conservationists who oppose such changes. The outcome of this struggle has important implications for some of the most contentious issues and concerning developments in contemporary politics. Since urban planning is often under local democratic control, local public opinion plays a central role in determining whether cities embrace or reject urban development. However, while we know much about what makes particular urban development project more or less popular, we do not have a theory that can explain why opposition to urban development varies across individuals or cities. This project advances a new research agenda to study public opinion on urban development. The project breaks new ground by developing a novel theoretical model which argues that when housing prices in an area increase, so does opposition to urban development among its residents. The project is also pioneering methodologically, combining quasi-experimental and survey-experimental research designs with cross-city surveys that explore and explain public opinion on urban development. As key empirical contributions the project develops a new survey instrument that quantifies opposition to urban development; implements this instrument in a survey of citizens in 200 cities across Western Europe and the US; and connect these survey responses to a series of innovative causally credible research designs that provide evidence on how the housing market shape citizen opposition to urban development across cities, residences and individuals. The project will significantly improve our understanding of a salient conflict in urban politics that shape the future of cities. Timely and innovative, the project will help us understand how and why current political conflicts over urban development will be settled differently in different cities.

Keywords: public opinion urban politics urban development housing markets comparative political behavior quasi experiments survey experiments
The Mathematical Analysis of Extremal Black Holes and Gravitational Radiation (ExBHGravRad)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1497500.0
EU funding (EUR): 1497500.0
Participants: 1
Project status: SIGNED

The Einstein equations constitute a system of geometric, nonlinear partial differential equations that describe gravitational dynamics in the framework of Einstein's theory of general relativity. The last decade has seen tremendous progress towards understanding dynamical aspects of the Einstein equations. At the mathematical level, great insight has been gained due to recent advances in the study of partial differential equations, differential geometry and microlocal analysis. The present proposal builds upon these advances in the context of the following two mathematical problems. Stability and instability of extremal black holes: Extremal Kerr black holes describe rapidly rotating solutions to the Einstein equations. They sit at the transition between black holes and "naked singularities" and exhibit critical geometric features. This proposal addresses the stability and instability properties of extremal Kerr black holes and is motivated by recent advances by the PI, which cover linear and nonlinear aspects. A successful resolution would give fundamental, new insights into the fate of perturbed extremal black holes and the transition between black holes and naked singularities. The late-time analysis of gravitational radiation: Gravitational radiation provides an observational window into deep mathematical aspects of general relativity. In this proposal, we investigate a key feature that is amenable to mathematical analysis: the existence of late-time tails in gravitational radiation. Recent work by the PI and collaborators has lead to the first proof of the existence of late-time tails in a toy model setting, also known as Price's Law. This proposal considers the full setting of the nonlinear Einstein equations via the analysis of late-time tails in the dynamics of perturbations of both flat spacetime and black hole spacetimes. A successful resolution would have important implications for the Strong Cosmic Censorship conjecture.
Deciphering SNPs involved in oligodendroglia functional resilience in multiple sclerosis (ResilMS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Multiple sclerosis (MS) is a prevalent demyelinating disease that primarily affects young adults. Current therapy for MS mainly focuses on immune suppression and alleviating inflammation. However, efforts to promote remyelination face challenges in clinical translation. Animal models of acute demyelination have demonstrated promising remyelination, primarily facilitated by newly generated oligodendrocytes. Nevertheless, the scenario in human MS differs, as the disease typically manifests in adulthood and the progression of lesions occurs over several decades. In the proposed project ResilMS, by using barcode based lineage tracing combined with ultra-depth single-cell and spatial transcriptomics, I will identify the molecular profiles of existing and newly generated oligodendrocytes at different stages of a mouse model induced with experimental autoimmune encephalomyelitis (EAE). The aim is to comprehend how an oligodendroglial cell pool diversifies its subpopulations during prolonged disease challenge, and what are the unique molecular properties for resilient cells to maintain their ability to endure an adverse inflammatory environment and remyelinate. Further, I will perform a screen of single nucleotide polymorphisms (SNPs) associated with risk and severity of MS that might affect genes related to the resilience of oligodendrocytes. To experimentally explore the effect of relevant SNPs, human oligodendrocyte cells (hOLGs) derived from pluripotent cells will be perturbed with CRISPR-based genetic modification and observed for cell profile and functional changes. The identified SNPs and resilience molecular pathways may play a critical role in disease progression for MS patients. By delving into the mechanisms of resilience of (re)myelinating cells in a long disease course, this project will provide valuable insights into MS-related genetic risk and protective factors, and potentially advance diagnostic and therapeutic approaches in MS research.

Keywords: multiple sclerosis,remyelination,oligodendroglia,single nucleotide polymorphisms
URV, committed to Gender Equality in practice (URV-GEP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: EU prize
Destination: EU Award for Gender Equality Champions
Action type: Recognition Prize
Countries involved: Spain
Call: Sustainable Gender Equality (HORIZON-WIDERA-2023-GENDER-Prize, 2023)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: SIGNED

The University Rovira i Virgili (URV) is the public university of Tarragona (Catalonia, Spain). Regarding gender equality, the URV has a significant and sustained record of actions and achievements through the implementation of its successive Gender Equality Plans (GEP). URV adopted its first GEP as early as 2007, being one of the pioneer universities in Catalonia and Spain. URV’s first GEP included the creation of the Equality Observatory in 2007 as a measure to guarantee sustained equality policies in all institutional structures and operations of the URV, and to transfer this value to society as a long-term commitment. A second GEP (2011-2019), object of this award application, was elaborated by the Equality Observatory, based on the good practices and lesson learnt of the first one. This GEP II completed a full lifecycle of diagnosis, planning, implementation and evaluation. The URV reaffirmed its commitment to gender equality in practice, by creating its Equality Unit, responsible for the design, implementation, and evaluation of the current GEP III (2020-2024), as well as the organisation of trainings, awareness-raising campaigns and advocacy. Over the years, URV’s sustained efforts in the field of gender equality at the university has led to a gender-balanced student and work force, protocols agains sexual harassment, and a positive opinion on the need for gender equality measures on a broader level. Although a lot of work still has to be done - for example with regard to the pay gap or the lack of gender balance in decision-making positions - the sustained impact of URV’s gender equality policies is guaranteed by a firm and long-term institutional commitment by means of its Equality Unit. URV is currently preparing its GEP IV (2025-2029) and is a role model and inspiration for other universities and educational institutions.

Keywords: universitat rovira i virgili,gender equality plan,gender perspective,sustained impact
Intercellular trading in nucleotide metabolism: an emerging target (InterMet)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Czechia
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-03-01
End date: 2027-02-28
Duration (months): 60.0
Total project cost (EUR): 1450000.0
EU funding (EUR): 1450000.0
Participants: 1
Project status: SIGNED

Anticancer therapy is >70 years old, and nucleotides are the oldest target in cancer treatment. Despite its long history, this treatment suffers high rates of resistance and toxicity. What are the reasons? A cell can gain nucleotides via de novo synthesis (DNS) or from salvage pathways. DNS inhibition can be bypassed by nucleotides produced by surrounding cells or distant organs, causing resistance. Cancer cells were traditionally studied in isolation, with (bulk) techniques precluding identification of cell type-specific targets, causing toxicity. To date, the cellular sources of nucleotides in healthy and tumor tissues are poorly characterized. Can the complexity of metabolic crosstalk in tissues be captured by the traditional means? I hypothesize that cancer and stromal cells differ in how they utilize nucleic acid building blocks from external and internal sources. A single cell resolution is needed to disentangle their interactions, and inhibition of both DNS and cancer-specific salvage is required for a successful blockade. I aim to define the nucleotide sources in heathy tissues and tumors, characterize their adaptations to DNS blockade to uncover the network of metabolic interactions in tissues and find effective and specific combinations of targets. To reach this goal, I will use a unique combination of single cell multi-omics and tailored mouse models, an expertise and tools that I took the lead to set up. I will selectively disable DNS in the stroma (host mouse) and in cancer cells (syngeneic lung tumors) to generate tumors dependent on internally or externally produced nucleotides. In an integrative approach using spatial and single cell transcriptomics & metabolomics in situ, and functional genetic screen, I will search for targetable metabolic vulnerabilities of DNS-disabled cancer cells. This innovative research opens the path to understanding the organization of tissue metabolic homeostasis for new personalized metabolism-based anticancer medicine.

Keywords: metabolism cancer single cell transcriptomics nucleotides de novo synthesis spatial omics
Education, Diversity, Innovation, and Politics (EDIPO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1463212.5
EU funding (EUR): 1463212.5
Participants: 1
Project status: SIGNED

The introduction of free and universal education, accessible to diverse religious and cultural groups, has been a major achievement worldwide and a crucial factor for economic development. However, still today, many countries do not guarantee full access to education, religious minorities often face restricted learning opportunities, and top educational institutions are being dismantled if they dissent from governments' policies. The over-arching goal of EDIPO is to study these extremely important phenomena through the lenses of quantitative economic history, focusing on France from the 1789 French Revolution to the 1900s. This was a period of educational reforms, key for French and, more broadly, for European modernization. The innovativeness of this proposal is twofold: (i) it constructs ground-breaking micro data from archival and secondary sources, of similar quality and detail of modern data, but for a longer time horizon; (ii) it identifies unique historical episodes to assess causality and to study the long-term effects. EDIPO is composed of three projects: Project 1 studies the process of expansion of mass education, from its demand to its consequences. Project 2 asks how discrimination affects schooling choices of religious minorities. Project 3 documents the impact of dismantling a high-quality but dissident educational institution on human capital, innovation, and political outcomes. EDIPO speaks to economists, economic historians, and political scientists. It sheds light on past and current instances of expansion and secularization of education, and it contributes to important public debates, e.g., the importance of achieving universal education; the increasing diversity of our society and the discrimination often faced by minority groups; and the dismantling of institutions training outstanding (but dissident) scholars.

Keywords: education,religiosity,xix century,france