Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Subcellular Lipid Atlas: Decoding Organelle Identity with Targeted Lipid Profiling (LipID)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-07-01
End date: 2031-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Organelle identity, defined by membrane and protein composition, is crucial for maintaining cellular organisation, functions and communication pathways. Disruption of organelle identity can lead to cellular dysfunction and severe health issues, such as fatty liver disease, cardiovascular diseases and lipid storage disorders. Although it is known that lipids are a hallmark of membrane identity, we still have a limited understanding of organellar lipid compositions. Particularly since lipids are very dynamic through transbilayer movement, local metabolism and lipid transfer between organelles, which requires a high temporal resolution to capture. While existing methods are effective for protein analysis, lipid profiling at the organelle level remains challenging. To answer the outstanding question of how organellar lipidomes shape organelle function, we propose an innovative chemical biology approach for organelle-specific lipid profiling. We will label the lipids of individual organelle membranes in vivo and determine their chemical identity and concentration by lipidomic profiling. We will first design and synthesise functionalised lipid probes for distinct organelles, allowing for their release and photo-crosslinking to endogenous lipids. By analysing the labelled lipids, we will acquire a precise and detailed lipid profiles of individual organelles, and furthermore characterise the lipidome of specific suborganellar membrane domains. This will allow us to define the organelle membrane identity of the major organelles with unprecedented spatial and chemical resolution. Such data will provide the much-needed basis to connect organelle identity and maintenance with function and the research community with open access, high-resolution lipid maps. This has the potential to change the way we think about biological membranes on a fundamental level, advancing not only our understanding of organelle function, but setting the stage to study its impact on health and disease.
Phenomenological Analysis of Ipseity and the Nature of Suffering (PAINS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Pain is a leading cause of disability globally, with approximately one in five adults across Europe reporting persistent pain that seriously impacts their lives. The growing personal and societal costs of pain have resulted in strong calls for innovative research to better understand the nature of pain-related suffering and how it can be effectively relieved. Indeed, there have been important developments characterizing pain-related suffering, including its central feature: disruption of one’s sense of self. Disruption of the self may include a loss or alteration of one’s self-identity due to pain (e.g., loss of a valued work role or activity), feeling overwhelmed or consumed by pain, or a painful body part feeling alien or disconnected from oneself. However, there is now a clear gap in the current scientific literature on pain-related suffering: little research has explored how one’s sense of self may be optimally restored or reconstructed through clinical interventions or self-management strategies. Before we can conduct this kind of empirical research, we first need to develop new pain-relevant research methods and theory to examine selfhood restoration and reconstruction. First, this project will develop and implement new qualitative methods to study how clinical interventions and self-management strategies deemed successful by pain sufferers have restored or reconstructed their sense of self. Combined with a robust synthesis of literature and expert consultation, these findings will enable the development of the first comprehensive and empirically grounded framework that specifies how various aspects of the self may be disrupted, restored, or reconstructed. This project will conclude with a series of evidence-based recommendations to help healthcare professionals collaborate with their patients to better target facets of the self to alleviate suffering.

Keywords: phenomenology,qualitative,selfhood
“(De)Colonizing Sharia?” Tracing Transformation, Change and Continuity in Islamic Law in the Middle East and North Africa (MENA) in the 19th and 20th Centuries (DeColSharia)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2554891.0
EU funding (EUR): 2554891.0
Participants: 1
Project status: SIGNED

European colonialism’s encounter with Islamic law or Sharia, the main pillar of the pre-colonial legal systems in the Middle East and North Africa (MENA), has had a tremendous impact until today. The implementation of modern European-style legal systems has led, as some scholars claim, to the abolishment of Sharia. Others consider the legal changes through which Muslim societies have transited as a sign of Sharia’s flexibility rather than its demise. The principal question this project addresses is: How was Sharia transformed by colonialism? The question mark in the project title “(De)Colonizing Sharia?” allows us to deliberately leave open the extent of the continuities, changes or ruptures that characterized Sharia during the colonial and the postcolonial periods and focuses on the processes of transformation. The project relies on extensive archival fieldwork and the intensive reading of texts to investigate the (1) codification/legislation, (2) jurisprudence/legal theory and (3) judicial institutions in six MENA countries representing diverse forms of the colonial encounter. We focus on the agency of legal actors, provide paradigmatic case studies for comparative evaluation and reflect on the fundamental terminological and theoretical questions underlying how “(De)Colonizing Sharia?” can be adequately grasped, researched and described. More broadly, my team and I expect high returns by challenging the scholarship grounded in European terminologies, theory and academic traditions in close cooperation with our colleagues in the MENA region. The project will, thus, break new ground by going beyond current approaches and claims, conducting in-depth and interdisciplinary comparative research on Sharia, and constructing a multivariable database of our outcomes. Its results will be highly relevant for contemporary academic and political discourses in Europe, the Middle East and elsewhere, and for the emerging field of decolonial legal studies.

Keywords: legal history of the middle east colonial law law in context sharia islamic law islamic studies sociology gender database historical court records decolonial research challenging eurocentric scholarship
SESAME’s Upgrading Network for Scientific user Training and Outreach into the Next Era (SUNSTONE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: France,Spain,Cyprus,Germany,Italy,Jordan,Switzerland
Call: Strengthening the international dimension of ESFRI and/or ERIC research infrastructures – consolidating the SESAME facility (HORIZON-INFRA-2024-SESAME-IBA, 2024)
Start date: 2024-06-01
End date: 2027-11-30
Duration (months): 42.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 9
Project status: SIGNED

SUNSTONE is dedicated to reinforcing the SESAME (Synchrotron light for Experimental Science and Applications in the Middle East) facility. This initiative includes eight key European and Middle Eastern research infrastructures and organisations, with the Paul Scherrer Institut as an associate participant. The primary aim of SUNSTONE is the sustained consolidation of SESAME, a pivotal research infrastructure utilised by eight member countries (Cyprus, Egypt, Iran, Israel, Jordan, Pakistan, Palestine and Turkey), along with other nations in the Middle East, and has an extended focus towards Africa. The project endeavours to bolster SESAME's scientific capabilities, service provision, and its standing as an international hub of research and excellence. The project addresses several crucial challenges: • Enhancing SESAME's visibility and membership in the Middle East through targeted outreach and promotional activities; • Guaranteeing the long-term sustainability of SESAME and its role in fostering African scientific advancement; • Broadening and educating a wider user community in light source techniques; • Elevating the quality of user support at SESAME facilities; • Amplifying the international influence of European light sources and their collaboration with SESAME; • Developing the capacity and skills of African researchers; • Tackling global societal issues by capitalising on SESAME's capabilities. SUNSTONE capitalises on past achievements and partnerships, deepening ties between European facilities, SESAME, and their respective user communities. As an associate to The League of European Accelerator-based Photon Sources (LEAPS), SESAME has strong European connections. In its outreach to Africa, SESAME's membership already includes Egypt, supplemented by ongoing collaborations with additional African entities. These connections will be strategically leveraged to effectively pursue objectives related to African scientific growth and capacity enhancement.

Keywords: synchrotron,sustainability,training,science diplomacy,middle east,africa,global challenges
Archaeal keystone species in host microbiomes: Understanding and controlling Methanobrevibacter for Environmental and Health Benefits (ARCH-METH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Archaea, the most ancient domain of life, play a crucial yet largely underappreciated role in human microbiomes and Earth's nutrient cycles. Among them, Methanobrevibacter species are particularly important for methane production in ruminants, accounting for up to 6% of anthropogenic greenhouse gas emissions and are prevalent in animal and plant microbiomes. In recent years, I have become intrigued by the impact of Methanobrevibacter on human physiology. Our research has shown that two distinct Methanobrevibacter species influence the availability of essential vitamins and metabolites by shaping the entire gut microbiome. Despite their recognized importance for health, our mechanistic understanding of archaeal dynamics and communication within the human microbial ecosystem remains limited due to technical challenges and a historical research bias. Methanobrevibacter never acts alone but relies on complex syntrophic, mutual interactions with bacteria. In these inter-domain networks, Methanobrevibacter functions as central hub. This creates an exciting possibility to strategically manipulate human microbiomes through a unique focus on the archaeal component. Given their distinct biological features, a major challenge is developing a robust methodological toolkit and engineering synthetic archaeal-bacterial consortia with therapeutic potentials. Through an integrative approach combining computational, experimental, and in vivo studies, I aim to elucidate the underlying mechanisms governing Methanobrevibacter networks, with the overall goal of elevating Methanobrevibacter to a central position in microbiome research. The gained knowledge will deepen scientific understanding of archaea and yield valuable applications in host-associated microbiomes. With extensive, globally unique expertise, a robust scientific network, and a validated methodological basis, I am poised to lead pioneering archaeome research with global implications for both environmental and human health.

Keywords: archaea,microbiome,methane,human physiology,syntrophy,microbial networks,synthetic microbial communities,in silico modeling,method development,genetic engineering,microbiology
Stochastic Spiking Wireless Multimodal Sensory Systems (SWIMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Belgium,Switzerland,Netherlands,Israel
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-01-01
End date: 2029-12-31
Duration (months): 72.0
Total project cost (EUR): 13525608.0
EU funding (EUR): 13525608.0
Participants: 5
Project status: SIGNED

SWIMS vision is to propose a bio-inspired paradigm change for the design and hardware of future smart wireless multimodal sensory systems that will operate with stochastic spikes, offering a breakthrough with unrivalled energy efficiency at system level, for event detections and communication. The scientific breakthroughs proposed here are sine qua non advancements for a sustainable deployment of billions of future Internet of Things nodes to support smart economy and society development, with large energy savings and limited impact on environment. The synergistic interaction of four complementary skilled PIs enables the realization of a radically-novel end-to-end stochastic analog spiking neuromorphic concept for SWIMS nodes, offering solutions to challenges of sensor spiking signal generation, processing and communication with disruptive innovations at all levels, inspired by the biological model of a small insect. SWIMS involves many beyond state-of-the-art scientific advancements from technology to system level to enable a neuromorphic architecture with i) as input neuron layer, new heterostructure spiking sensor arrays based on transition metal oxides/2D semiconductor, covering infrared, ultraviolet, acoustic and electromagnetic detections, ii) hidden layers in tiny spiking neural networks based on novel CMOS Fe-FET concepts capable of efficiently dealing with inherent stochastic noise when processing spiking signals on-chip, iii) a spiking emitter as output layer for event-driven wireless transmission using optimized spike modulation and encoding, and iv) a modelling framework embedding stochastic effects in task-based electronic system design and biologically inspired recurrent neural networks. The synergistic interaction will enable unique design and experimental validations of first of their kind event-driven demonstrators with optimized all spiking multi-modal sensor nodes and energy consumption more than 100x lower than existing state of the art.

Keywords: cmos,iot edge nodes,integrated circuits,ultra low power,phase change and ferroelectric devices,modulation and coding,non gaussian uncertainties,stochastic spiking sensors
Unlocking LiDAR technology for European OEMS: For a future of smart and safe Traffic and Mobility (SE€)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 3546520.0
EU funding (EUR): 2482564.0
Participants: 1
Project status: CLOSED

Xenomatix is radically innovating the standard operating principle of LiDAR by introducing a light-based 3D measurement system, and is the first to design the by market defined holy grail being a true solid state LiDAR. XenomatiX’s unique all semiconductor-based design is first to meet cost, size, and robustness requirements without compromising measurement performance. XenoLiDAR, XenomatiX high-resolution true solid-state LiDAR generates 8D environmental measurement data (2D, 3D, intensity images, time and confidence levels) guaranteeing superior detection reliability. With zero moving parts, XenoLidar is a complete system-on-chip as demanded by automotive OEMs. Abandoning traditional light projection schemes and radically turning around how light is projected into the environment, XenomatiX reveals the 1st true solid-state LiDAR with 100% proven silicon components to supply the B€ automotive Lidar market.

Keywords: lidar for automotive mass production,metrology and measurement,lidar,sensors,cameras
Deep U-tube heat exchanger breakthrough: combining laser and cryogenic gas for geothermal energy exploitation (DeepU)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Ireland,Italy,Poland
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-03-01
End date: 2025-10-31
Duration (months): 44.0
Total project cost (EUR): 3425640.75
EU funding (EUR): 3425640.75
Participants: 7
Project status: SIGNED

The future disruptive technology envisioned in “Deep U-tube heat exchanger breakthrough: combining laser and cryogenics gas for geothermal energy exploitation (DeepU)” Project is expected to revolutionize the deep geothermal energy sector. The ultimate goal is to create a deep (>4 km) closed-loop connection in the shape of a U-tube exchanger, combining laser and cryogenic gas in a single technological drilling solution. Specific temperature control analysis and innovative laser lenses able to convey the heat and to sustain multilateral drilling will be developed alongside the U-tube creation, guaranteeing liquefaction and vitrification of the rocks from ground surface to greater depths. Then, a U-tube system ready to exchange heat with the underground becomes the main tool to exploit or store geothermal energy, meeting energy needs in power and thermal energy production. Hence, DeepU project targets a novel and ambitious science-to technology breakthrough in the field of geothermal exploitation. The overall aim is the creation in laboratory of a vitrified, waterproof, non-cracked U-tube exchanger for different kind of rocks. This will be achieved by a laser drill head combined with special drill strings sustaining the coupled action of laser and cryogenic gas, responsible for melting, evaporating and cooling even the hardest rocks. Then, (i) the physical-thermal phenomena affecting the rocks, (ii) an evaluation of the legislative aspects and environmental standard related to the innovation proposed, (iii) the modelling of the DeepU geothermal exploitation potential considering some virtual case studies will be assessed. The high-risk innovation proposed has the potential to make geothermal energy systems accessible anywhere in a targeted and demand-oriented manner, offering a complimentary approach and an alternative solution to traditional energy storage and production, decentralizing the power supply also in areas where this is currently deemed uneconomic.

Keywords: u tube heat exchangers,deep geothermal energy,rocks melting and vitrification,laser beams drilling,cryogenic gas,geothermal exploitation modelling energy,
MetaCities Excellence Hub in South-Eastern Europe (METACITIES)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Cyprus,Bulgaria,Netherlands
Call: Excellence Hubs (HORIZON-WIDERA-2022-ACCESS-04, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4994500.0
EU funding (EUR): 4994500.0
Participants: 22
Project status: SIGNED

Three place-based innovation ecosystems in Cyprus, Greece and Bulgaria partner together to create an Excellence Hub for Future Cities and Regions in Southeast Europe (SEE). The METACITIES Excellence Hub is a sustainable network that offers a common platform for collaboration, cross-fertilization, and best practices sharing across borders, sectors and disciplines on knowledge production, circulation and use. Founded upon a joint R&I strategy, a nexus of collaborative links across sectors, joint research, innovation and outreach activities as well as business modelling and sustainability plans, the collaboration aims to benefit citizens, stakeholders, regional ecosystems and the whole SEE region. The thematic focus on future and metaverse cities necessitates the definition of ambitious R&I agendas and the uptake of advanced digital technologies. Digital Twins (DT) of future cities/regions provide accurate and reliable reference representation seamlessly unifying the physical, digital and human worlds and enabling stakeholders to assess the effects of any changes before investments and implementations actually occur. The proposed Open Digital Twin Framework facilitates co-development of complementary future city domains along with their equivalent DTs. The applied Quadruple Helix Model forges synergies among actors and alignment of public and private sector priorities for regional development. PoC studies, small-scale pilots and feasibility assessments validate project outcomes. Green Business and Operation Models will be developed for future and metaverse cities, as well as for the METACITIES Excellence Hub. Investment and Sustainability Plans will mobilize the communities of the three innovation ecosystems to progress faster in joined efforts. Common investment plans for R&I, infrastructures and support for real-life experimentation, aim to leverage national, regional and European funds as well as crowd funds and private capital in a synergetic manner.

Keywords: excellence hubs,place based innovation ecosystems,quadruple helix,smart cities,metaverse,digital twin,joint randi strategies,randi pilot projects