Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Geometry and Anomalous Dynamic Growth of Elastic instabiliTies (GADGET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-06-30
Duration (months): 63.0
Total project cost (EUR): 1361077.0
EU funding (EUR): 1361077.0
Participants: 1
Project status: CLOSED

Elastic instabilities are ubiquitous, from the wrinkles that form on skin to the ‘snap-through’ of an umbrella on a windy day. The complex patterns such instabilities make, and the great speed with which they develop, have led to a host of technological and scientific applications. However, recent experiments have revealed significant gaps in our theoretical understanding of such instabilities, particularly in the roles played by geometry and dynamics. I will establish a group to develop and validate a theoretical framework within which these results can be understood. Central to my approach is an appreciation of the crucial role of geometry in the pattern formation and dynamics of elastic instabilities. As a starting point, I will consider the model problem of a pressurized elastic shell subject to a geometrically large deformation. This system develops either wrinkles or a stress-focusing instability depending on the internal pressure. As such, this is a natural paradigm with which to understand geometrical features of deformation relevant across length scales from deformed viruses to the subduction zones in Earth’s tectonic plates. My team will combine theoretical and computational approaches with tabletop experiments to determine a new set of shell deformations that are generically observed in contradiction of the classic ‘mirror buckling’. Understanding why these new shapes emerge will transform our perception of shell instabilities and provide new fundamental building blocks with which to model them. These ideas will also be used to transform our understanding of a number of other, previously mysterious, elastic instabilities of practical interest. Turning our focus to the dynamics of instabilities such as the snap-through of shells, we will show that accounting for geometry is again crucial. The new insight gained through this project will increase our ability to control elastic instabilities, benefitting a range of technological and scientific applications.

Keywords: theory of elasticity
SMART PIXEL EMITTERS FOR DISPLAY (SPEED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2023-01-31
Duration (months): 30.0
Total project cost (EUR): 3462490.0
EU funding (EUR): 2423743.0
Participants: 1
Project status: CLOSED

Aledia develops and manufactures a µLED (micro light-emitting diode) display technology based on a unique 3D architecture using gallium-nitride (GaN)-on-silicon nanowires (WireLED™). This technology can be applied in SmartPixels, where each µLED is directly controlled by a CMOS circuit for displays from the size of a smartphone to giant TVs. Aledia has developed this technology on 200mm silicon wafers and plans to scale it up to 300mm silicon substrates, giving high manufacturing yield. The purpose will be to provide display designers and assemblers with a disruptive technology as it can remove the need for a TFT layer in displays. This unlock the possibility to design truly flexible displays, giant TV screens, or smart displays (haptic…). For the first time ever, the display industry can be relocated in Europe if required since the SmartPixel will allow to bypass the Asian monopoly of the TFT layer. µLeds with a pitch of less than 10µm, each one independently controlled by its own control command, will be available as soon as 2024, thus overcoming best experts’ estimates.

Keywords: microelectronics,displays,microled,led
An Ecosystem of Citizen Observatories for Environmental Monitoring (WeObserve)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Coordination and support actions
Countries involved: Italy,Germany,Spain,Austria,Greece,Netherlands,United Kingdom
Call: Coordination of citizens' observatories initiatives (H2020-SC5-2017-OneStageB, 2017)
Start date: 2017-12-01
End date: 2021-03-31
Duration (months): 40.0
Total project cost (EUR): 1069507.5
EU funding (EUR): 1069507.5
Participants: 8
Project status: CLOSED

The rising trend in citizen science has led to the development of Citizen Observatories (COs) for environmental monitoring, which have been supported in FP7 and H2020. To improve the coordination between existing COs and related regional, European and international activities, the WeObserve Coordination and Support Action will tackle three key challenges that face COs: awareness, acceptability and sustainability. The WeObserve mission is to create a sustainable ecosystem of COs that can systematically address these identified challenges and help move citizen science into the mainstream. The WeObserve approach will apply several key instruments to target, connect and coordinate relevant stakeholders. The first is to develop and foster five communities of practice to strengthen the current knowledge base surrounding COs. Topics will include citizen engagement, the value of COs for governance and CO data interoperability. In co-creating this knowledge base, CO practitioners will have a platform to effectively share best practices and avoid duplication. The second will expand the geographical reach of the knowledge base to different target groups via toolkits, a Massive Open Online Course, capacity development roadshows and an Open Data Exploitation Challenge, to strengthen the uptake of CO-powered science by public authorities and SMEs. A third mechanism will forge links with GEOSS and Copernicus to demonstrate how COs can complement the EU’s Earth Observation monitoring framework. The WeObserve consortium brings together the current H2020 COs (Ground Truth 2.0, GROW, LandSense, Scent) who will actively open up the CO landscape through wide ranging networks, users and stakeholders, including ECSA, GEOSS and Copernicus to foster social innovation opportunities. The WeObserve approach and outcomes have the potential to create a step-change in EO innovation and make COs a valuable component of managing environmental challenges and empowering resilient communities.

Keywords: citizen observatories,citizen science,coordination,geoss,copernicus,stakeholders
Synthetic Cell Biology: Designing organelle transport mechanisms (ArtifiCell)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France,United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 2200000.0
Participants: 2
Project status: CLOSED

Imagine being able to design into living cells and organisms de novo vesicle transport mechanisms that do not naturally exist? At one level this is a wild-eyed notion of synthetic biology. But we contend that this vision can be approached even today, focusing first on the process of exocytosis, a fundamental process that impacts almost every area of physiology. Enough has now been learned about the natural core machinery (as recognized by the award of the 2013 Nobel Prize in Physiology or Medicine to the PI and others) to take highly innovative physics/engineering- and DNA-based approaches to design synthetic versions of the secretory apparatus that could someday open new avenues in genetic medicine. The central idea is to introduce DNA-based functional equivalents of the core protein machinery that naturally form (coats), target (tethers), and fuse (SNAREs) vesicles. We have already taken first steps by using DNA origami-based templates to produce synthetic phospholipid vesicles and complementary DNA-based tethers to specifically capture these DNA-templated vesicles on targeted bilayers. Others have linked DNA oligonucleotides to trigger vesicle fusion. The next and much more challenging step is to introduce such processes into living cells. We hope to break this barrier, and in the process start a new field of research into “synthetic exocytosis”, by introducing Peptide-Nucleic Acids (PNAs) of tethers and SNAREs to re-direct naturally-produced secretory vesicles to artificially-programmed targets and provide artificially-programmed regulation. PNAs are chosen mainly because they lack the negatively charged phosphate backbones of DNA, and therefore are more readily delivered into the cell across the plasma membrane. Future steps, would include producing the transport vesicles synthetically within the cell by externally supplied origami-based PNA or similar cages, and - much more speculatively - ultimately using encoded DNA and RNAs to provide these functions.
An integrated decision-making platform for the prediction, prevention and extinction of wildfires in real-time. (SAFETY FOREST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wildfires have severe impacts on society, the environment and on human lives. They destroy 400,000 ha/yr. on average, mainly in Mediterranean countries, costing around €400M/yr. and causing more than 100 deaths in a single year. In spite of the technological advances of the recent decades, local authorities, institutions and the forestry sector still need timely and reliable solutions that provide real-time monitoring, prevention and risk assessment of wildfires. SAFETY FOREST is a disruptive platform for decision-making in preventing, predicting and extinguish wildfires in real time. It manages all variables needed through combination of pre-processed remote sensing data, cloud computing, machine learning and modelling tools. SAFETY FOREST intuitive interface will enable to promptly act integrating multiple data sources and big data analytics making it disruptive platform for public and private forest managers. Technically we seek the feasibility of the integrated platform while commercially we look forward to engage international stakeholders to launch SAFETY FOREST to the EU market. Risk monitoring is a critical task to reach the main goals (EU forest strategy 2030) and to prevent the high impact related to wildfires. The downstream chain of the earth observation data is a huge opportunity to develop value-added solutions to multiple business. SAFETY FOREST model is based on sales of licenses through our e-commerce web, perfectly aligned with VERMON core business. Our customers and forest associations will act as channels and help us raise awareness and disseminate our product. Other main activities that can integrate SAFETY FOREST are spatial data research and information system development which will create new market opportunities.

Keywords: wildfire,prevention,prediction,extinction,machine learning,fuel models,cartography,satellite images,real time,sensor grid
Interferometric Survey of Stellar Parameters (ISSP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2692447.0
EU funding (EUR): 2692447.0
Participants: 1
Project status: SIGNED

Fundamental stellar parameters are the primary data required for an in-depth understanding of stars, their interiors, and their environments. With the progress of stellar physics and the prospects of ground facilities or space missions, it is critical to improve the accuracy, and quantity of such data. The development of exoplanet and asteroseismology domains is demanding direct data to eliminate any bias in the parameters. And finally, the differences between methods for determining the Hubble constant is motivating new and precise direct determination of distances on the primary candles of the cosmic scales. Many methods like asteroseismology, photometric transits of exoplanets, radial velocities, or Surface Brightness Colour (SBC) relations are linked to the stellar radius. Usually estimated through models, its determination by coupling an optical interferometric measurement of the angular diameter and, for example, a Gaia parallax, is the best way to avoid any model dependence. Furthermore, characterizing any activity (limb darkening, convection, rotation, spots, or binarity) is also mandatory, both for bias removal and for the required progress on stellar physics. Through an ambitious and homogenous survey of the angular diameters of a thousand stars as faint as magnitude 8 in the visible and as small as 0.2 milliseconds of arc, my project is built to address key questions about the relation between planets and stars and to offer to the broader community a unique and primary source of direct information on a representative and large sample of stars all over the HR diagram. A few hundred of direct measurements of limb darkening will be accessible, and, for about 100 stars, activity characterization with a more detailed surface imaging will be possible. These data will also permit the development of new unbiased SBC relations to serve the faint targets of space missions like PLATO or ARIEL in the future and the distance scale within the Araucaria project.

Keywords: fundamental parameters of stars,optical interferometry
Stromal cells as primary drivers of immunopathology: towards targeted disease modification in spondyloarthritis (Inflammostrome)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2018-12-31
Duration (months): 42.0
Total project cost (EUR): 1599466.25
EU funding (EUR): 1599466.25
Participants: 1
Project status: CLOSED

Pro-inflammatory cytokines play a crucial role in chronic inflammatory diseases. Focusing on spondyloarthritis (SpA), a prevalent and debilitating rheumatic condition characterized by inflammation and abnormal new bone formation, we demonstrated that TNF and IL-23/IL-17 inhibition potently blocks inflammation. However, these treatments have no proven effect on pathologic new bone formation and the resulting structural damage, indicating the unmet need for understanding upstream disease mechanisms. Immune cells, in particular myeloid cells, have been shown to be the major sources of TNF and IL-23 in experimental models. However, we and others failed to demonstrate abnormal cytokine production by myeloid cells in human SpA. What drives these pathogenic cytokines thus remains unknown. We recently found that SpA synovial tissues contain an abnormal stromal population of myofibroblasts, that these myofibroblasts express TNF and IL-23 in vivo and in vitro when exposed to cellular stress, and that stromal expression of these cytokines does not only drive inflammatory responses in vitro but is required and sufficient to induce experimental SpA in vivo. Therefore, we propose that stressed stromal cells can act as primary drivers of cytokine-mediated tissue inflammation and remodelling. Using a translational approach - dynamic sampling of primary human target tissues, functional experiments ex vivo and in vitro, animal models, and targeted interventions in patients – we aim to unravel the role of stromal cells in SpA by defining: 1) the molecular profile of the stromal alterations, 2) the mechanisms of cytokine production by stromal cells, 3) the activation of downstream inflammatory pathways, 4) the role of stromal alterations in tissue remodeling, and 5) the contribution of stromal pathways to experimental and human SpA. Collectively, this project will allow to validate stromal cells as novel therapeutic targets for SpA and related disorders.

Keywords: inflammatory diseases,anti cytokine therapy,disease remission,therapeutic targets
BLUE HEALTH (BLUE HEALTH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project’s overriding aim is to develop a new system for the processing of semi-preserved anchovies, produced by a salting process, which allows creating a new kind of anchovy that has a reduced salt content, and does not need to be refrigerated for its retail and storage. The results of the innovation project are as follows: • A new kind of preserved anchovy that is much healthier, with a much lower salt content (2,25%), which can be stored at room temperature for up to 12 months, which does not contain histamine, which is 100% natural and which keeps all the organoleptic and nutritional properties of the anchoa del cantábrico variety of anchovy There is no other product of similar characteristics on the market, and unlike its competitors, FREDO is in a position to provide this new type of product, defining a new production process, and providing certain features that are expected to fill a current gap in the market. Providing to the customers with an extremely healthy and nutritional product, without the drawbacks of salt. • A new manufacturing process that is largely automated, thereby leading to a lower cost of processing the anchovy, making it more competitive on the market. The new pilot process will introduce changes regarding the centrifuge spinning, washing, drying, freeze-drying, sublimation, automation of the entire packaging process, and incorporation of new automation technologies (collaborative robotics and artificial vision), making it an new process that will speed up the anchovy’s production rate at a lower cost. FREDO is going to invest in two processes, and so it aspires to license the new process as a way of exploiting this innovation, multiplying its financial return, with the medium-term target being to license between ten and twelve companies, whereby this variety of anchovy will corner a significant market share. FREDO has a multidisciplinary team that will be complemented by professional staff from the CTIC-CITA and ITCL technology centr

Keywords: collaborative robotics,artificial vision,sublimation,histamine,reduced salt
Contribution of distinct pyramidal cell types in hippocampal area CA1 to episodic memory formation (CA1 layers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The formation of episodic (unique event) memories is based on the interaction between the hippocampus and the cortical regions that receive its output. The major hippocampal output cells are pyramidal cells (PCs) in area CA1. In rodents, populations of CA1 PCs are known to represent a wide range of aspects associated with an episodic memory: Some cells participate in the formation of a map-like representation of space, while others additionally or exclusively encode items within the environment, represent meaningful locations, or participate in the representation of emotional and behavioural contexts. It is not known so far how heterogeneous CA1 firing patterns are organized and affect memory formation. While CA1 PCs have been traditionally considered a homogeneous cell population, we now have clear evidence for the presence of at least two distinct CA1 PC cell types that differ in their local and long-range connectivity, in their morphology, their molecular makeup and their basic firing patterns. This strongly argues for a functional specialization within the CA1 area. However, a link between the heterogeneous representation of mnemonic information and the presence of anatomically distinct PC types remains to be established. In this proposal I aim to determine whether heterogeneous response properties of CA1 PCs are based on computations in distinct anatomical microcircuits in deep and superficial layers by combining optogenetic and chemogenetic techniques with in vivo recordings in behaving mice. Furthermore, I will seek to obtain detailed knowledge about the functional connectivity between different CA1 PC populations and their target areas. Knowledge about the function of individual CA1 microcircuits and their anatomical connections is the prerequisite to subsequently develop an independent research plan aiming to determine how intra-hippocampal processing affects memory formation in their downstream targets.

Keywords: hippocampus,place cells,optogenetics,in vivo recordings,functional microcircuits,deep and superficial ca1 layers,spatial memory,episodic memory