Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Defeat of Insider Theft in Nuclear and Radioactive Sites (IMPRINT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Israel
Call: Critical infrastructure protection topic 7: SME instrument topic: Protection of Urban soft targets and critical infrastructures (H2020-SMEINST-2-2015, 2015)
Start date: 2015-12-01
End date: 2017-11-30
Duration (months): 24.0
Total project cost (EUR): 1474325.0
EU funding (EUR): 1032027.0
Participants: 1
Project status: CLOSED

Insider threats are perhaps the most serious challenges that nuclear security systems face. All of the cases of theft of nuclear materials where the circumstances of the theft are known were perpetrated either by insiders or with the help of insiders; given that the other cases involve bulk material stolen covertly without anyone being aware the material was missing, there is every reason to believe that they were perpetrated by insiders as well. The need is to detect shielded and unshielded Special Nuclear Materials ("SNM") and radioactive materials is necessary. Radiation Monitors are effective to detect unshielded or partially shielded nuclear and radioactive materials in lightly loaded vehicles or cargos, and less effective at dense or high attenuating vehicles. In addition, the radiation monitors are not effective to detect shielding (e.g. lead) inside the vehicles that are capable to transport large masses of shielding material. Specifically, one of the biggest gaps is that some SNMs emit very low level of radiation. The X-ray cannot clear every dense object found in the image. Active interrogation can be used to clear the alarms; however, they produce high radiation that requires shielded facility, and require passengers not to remain in the vehicle during the inspection. Therefore, there is a need for inspection systems that can penetrate high attenuating vehicles, be specific to nuclear and shielding materials and that can be steal from the sites. . Lingacom is developing an innovative Muon Detection System for detecting high-Z materials used in nuclear bombs and shielded radioactive materials (used in “dirty bombs”) in containerized cargo and vehicles. The company has built a highly skilled and experienced team that has developed and demonstrated successfully key detection capabilities of high-Z materials including building a cost-effective muon detection proof of concept (PoC) prototype.

Keywords: nuclear,cbrne,muons,insider theft,shielded
Expanding and extending gene therapy of monogenic diseases of the haematopoietic system (GENE FOR CURE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2023-09-30
Duration (months): 84.0
Total project cost (EUR): 2445267.52
EU funding (EUR): 2137827.52
Participants: 2
Project status: SIGNED

Given that (i) not all patients with a monogenic disease affecting the lymphohaematopoietic system have an HLA-genoidentical sibling donor and (ii) severe immunological complications worsen the outcome in HLA-partially-matched hematopoietic stem cell transplantation (HSCT), the genetic modification of autologous hematopoietic stem cells (HSCs) has become a powerful curative treatment option for these individuals. The present project seeks to further consolidate the rationale for replacing HLA-partially-matched HSCT with a gene therapy approach. Wiskott-Aldrich syndrome is a primary immunodeficiency whose severity is due to impairment of both lymphoid and myeloid cell function. We have reported robust evidence showing that the infusion of gene-corrected autologous HSCs enables the restoration of the T cell function. However, we are still cautious with regard to claiming the stable correction of autoimmunity and thrombocytopenia. Accordingly, we plan to thoroughly monitor long-term B cell functional outcomes and the platelet count in our treated patients. Moreover, we wish to extend the gene therapy approach to the SCID caused by mutations in the DLREIC gene, since the long-term post-HSCT outcomes are particularly poor. The preclinical work has been completed; initiation of a clinical protocol is the next step. Immune-dysregulation polyendocrinopathy enteropathy X-linked (IPEX) and sickle cell anaemia (SCA) are the last two target diseases. IPEX is a devastating disease caused by mutation of FOXP3 transcription factor; it may be possible to correct it by infusing gene-modified CD4+Tcells. We intend to accumulate the data required to prove our working hypothesis. SCA is a worldwide public health issue. We are seeking to improve the conventional gene therapy procedure and to evaluate the efficacy of CrisP/Cas9-mediated disruption of the CIS-regulatory elements required for HbF silencing. This disruption may provide a cure for SCA.

Keywords: genetic diseases of the hematopoietic stem cells,blood cells
Advisory platform for small farms based on earth observation (APOLLO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Innovation actions
Countries involved: Austria,Spain,Spain,Serbia,Serbia,Greece,Greece,Belgium,Greece
Call: Bringing EO applications to the market (H2020-EO-2015, 2015)
Start date: 2016-05-01
End date: 2019-02-28
Duration (months): 34.0
Total project cost (EUR): 2135785.71
EU funding (EUR): 1707056.25
Participants: 9
Project status: CLOSED

The overall objective of APOLLO is to develop a commercial platform that will provide a suite of farm management advisory services specifically designed to address the needs of small farmers. APOLLO will use state-of-the-art methodologies for the calculation of agricultural parameters based on EO data, taking advantage of the improved spatial and temporal coverage of the new Sentinels. APOLLO will produce data on agricultural parameters through available EO, meteorological, and auxiliary data. Especially for the calculation of soil moisture, SAR images will be used for the first time with Sentinel-1, making it possible to obtain maps with a spatial and temporal resolution not achievable before. Based on the agricultural parameters calculated, a suite of farm management services (tillage scheduling, irrigation scheduling, crop growth monitoring, and crop yield estimation) will be developed, and will be delivered through a web and mobile interface. The service requirements will be elaborated in close collaboration with end users. APOLLO services will be cost-effective and affordable, thanks to access to free and open Copernicus data, an automated processing chain for the delivery of agricultural variables, independence from the need for ground-based sensors, and the pioneering use of Sentinel-1 data for estimating soil moisture information. The APOLLO platform and business case will be validated through pilot testing in Spain, Greece, and Serbia, with the participation of small farmers, agricultural consultants, farmers’ associations, and SMEs providing farm management services. A business strategy for the take-up of APOLLO will be developed, assessing the operational sustainability of the platform based on market revenues. According to the preliminary business plan developed, APOLLO has the potential for a Return On Investment (ROI) of 18% - 51% in 3 years (for the low and high uptake scenario, respectively).

Keywords: farm management,agriculture,small farms
Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma (mTORmorS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-15
End date: 2021-04-14
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and a leading cause of cancer death worldwide. Inactivation of different tumor suppressors, whose cooperation forms tumor suppressor networks, has been linked to HCC development, but the genetic events involved in HCC are still poorly understood. Mammalian target of rapamycin (mTOR) signaling is essential for cell growth and metabolism, and its hyper-activation plays an important role in pathogenesis and prognosis of HCC. However, the relationship between mTOR signaling dysregulation and the tumor suppressor networks in HCC, and whether mTOR inhibition could be a therapeutic strategy in some types of HCC remain largely unknown. Here I propose to use a genome-wide CRISPR knockout library to screen potential tumor suppressors in implanted mouse HCC models. The mouse hepatocytes depleted of different mTOR pathway components, with differential mTOR activities, will be separately infected with the CRISPR knockout library and implanted into immunocompromised mice to induce tumor. The goal of the proposed project is to understand the role of mTOR signaling dysregulation in the tumor suppressor networks in HCC. The specific objectives are: 1) to understand the tumor suppressor networks in HCC with differential mTOR activities in a genome-wide scale, 2) to examine how mTOR dysregulation controls the landscape of tumor suppressors, and 3) to explore whether mTOR inhibition could be developed as a treatment for specific subclasses of HCC. Using a combination of state-of-the-art CRISPR screening, molecular and cell biology, mouse models, next-generation sequencing, and bioinformatics tools, this project will link the mTOR signaling to tumor suppressor networks. This study will also unravel fundamental mechanisms underlying liver cancer development and contribute to potential targeted therapy.

Keywords: mtor,mtorc1,mtorc2,tsc1,pten,hepatocellular carcinoma,liver cancer,tumor,suppressor,crispr,genome wide screening,metabolism
The Construction of Values in Digital Spheres (DigitalValues)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-08-01
End date: 2025-07-31
Duration (months): 72.0
Total project cost (EUR): 1985000.0
EU funding (EUR): 1985000.0
Participants: 1
Project status: SIGNED

In recent decades, social media has emerged as a central arena for the construction of values. Artifacts such as YouTube videos, Facebook posts, and tweets reflect and shape what people across the globe consider important, desirable, or reprehensible. Understanding this pervasive value ecology is key to deciphering the political, cultural, and social processes governing the twenty-first century. In this project, I will conduct the first comprehensive study of values in social media. I will explore the following over-arching questions: How are values constructed through social media? Which values are emphasized in these spheres? To what extent are social media platforms associated with the globalization of values? In addressing these fundamental issues, I will apply an entirely new approach for the conceptualization and study of values. Carried out comparatively in five languages, DigitalValues will explore the interaction between three facets of value construction: (a) explicit uses of the terms “value” and “values”; (b) the implicit construction of values in genres of user-generated content; and (c) users’ interpretation and evaluation of values through both private meaning-making and public social practices of commenting, sharing, and liking. The project is theoretically, empirically, and methodologically groundbreaking in a number of ways: (1) it will be a pioneering large-scale study employing inductive methods to explore the construction of values through everyday cultural artifacts; (2) as a foundational study of values in social media, it will yield a novel theory of value construction as an intersection between individuals, technologies, and sociocultural contexts; (3) it will generate new methods for infering values from verbal texts, combining qualitative, quantitative, and automated analyses; (4) finally, it will yield a comprehensive map of values as expressed across languages and platforms, leading to a new understanding of the globalization of values.

Keywords: digital culture,globalization,social media,user generated content,values
Virtual Anthropology of Prehistoric Portugal (VAPP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-06
End date: 2022-01-05
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

The VAPP Project will examine prehistoric human population dynamics and microevolution in Portugal through the analysis of dental morphological variation. Variation in external dental morphology (e.g., size, shape, and discrete characteristics) provides reliable data on biological affinity and relatedness within and between human populations, as well as signatures of selection on dental functional morphology related to different diets and masticatory regimes. Advances in non-invasive, virtual imaging technology provide complimentary, high-resolution data on internal dental morphology (e.g., enamel thickness, tissue proportions, enamel dentin junction shape) that address key aspects of dental morphological variation and evolution. Nevertheless, few studies have focused on how internal dental morphology varies among human populations during the Holocene, and only one Homo sapiens dentition from Portugal has been virtually analyzed to date. The prehistory of Late Pleistocene to Mid-Holocene Portugal is characterized by complex environmental, climatic, and demographic changes that significantly altered socioeconomic organization, thus making it an ideal regional case study to address human biocultural evolution through an integrated approach to internal and external dental morphology. The VAPP Project will include Upper Paleolithic humans, the last foraging populations (Mesolithic), early food-producing peoples (Neolithic), and groups associated with the emergence of social complexity and the intensification of food processing (Late Neolithic, Chalcolithic, and Bronze Age). The sampling strategy provides a nuanced perspective on dental microevolution corresponding to changing diets, socioeconomic strategies, and spatiotemporal population dynamics (e.g., migration, integration, and replacement) across crucial transitional periods in Portuguese prehistory. Notably, the VAPP Project will establish the first, open-source, virtual dental anthropology dataset for the region.

Keywords: bioarchaeology,dental anthropology,virtual anthropology,microcomputed tomography,paleolithic,mesolithic,neolithic,bronze age,microevolution,biocultural evolution,foraging,food production
New ICT infrastructure and reference architecture to support Operations in future PI Logistics NETworks (ICONET)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Ireland,Spain,Germany,Italy,Cyprus,Belgium,Belgium,Belgium,Poland,Greece,France,Netherlands,Portugal
Call: Potential of the Physical Internet (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-09-01
End date: 2021-02-28
Duration (months): 30.0
Total project cost (EUR): 3078698.75
EU funding (EUR): 3078698.25
Participants: 18
Project status: CLOSED

ICONET will significantly extend state of the art research and development around the PI concept in pursuit of a new networked architecture for interconnected logistics hubs that combine with IoT capabilities and aiming towards commercial exploitation of results. ICONET strives to achieve the end commercial goal of allowing shipments to be routed towards final destinations automatically, by using collaborative decisions inspired by the information centric networking paradigm, and optimizing efficiency and customer service levels across the whole network. According to this vision, cargo regarded as smart physical packets will flow between hubs based on ‘content’ of the cargo influencing key commercial imperatives such as cost, optimisation, routing, efficiency and advancing EU's Green agenda. Consequently, the consortium are discernibly aimed at three (3) avenues of commercialisation and exploitation from the ICONET innovation, specifically targeted in the areas of (a) Warehousing as a service, (b) E-commerce fulfillment as a service, and (c) Synchromodality as a service. PI based logistic configurations will be simulated, prototyped and validated in the project . Modelling and analysis techniques will be combined with serious game type simulation, physical and digital prototyping, using living lab (LL) requirements scenarios and data. With analyses and simulations, optimal topologies and distribution policies for PI will be determined. The project implementation will be based on a succession of phases of modelling and design/prototyping, learning and experimentation and feedback and interaction with the wider business community, including the ALICE logistics platform as well as members of the partner Associations ESC, UIRR and ELUPEG. Through its Living Labs, the project will address under the PI paradigm both Supply Network Collaboration and Supply Network Coordination.

Keywords: physical internet
Self-calibrating nanobolometer based on superconductor–normal-metal hybrids (SNABO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2016-12-01
End date: 2018-05-31
Duration (months): 18.0
Total project cost (EUR): 149838.0
EU funding (EUR): 149838.0
Participants: 1
Project status: CLOSED

In this project, we develop a microwave nanobolometer invented in the ERC Starting Grant ”Single-Photon Microwave Devices: era of quantum optics outside cavities (SINGLEOUT)” into a proof of concept and carry out a market analysis and partnering with the relevant industrial players in the field. For a successful proof of concept, a self-calibrating function will be implemented into the nanobolometer, providing us with an extremely sensitive and easy-to-use detector for microwave radiation. The new device will be designed, fabricated, and measured. Due to the lack of spectrum analysers operating at cryogenic temperatures, our self-calibrating nanobolometer will provide a must-to-have piece of equipment for R&D facilities working on cryoelectronics and quantum technology. Thus licensing agreements with companies working on cryostats and cryosystems will be pursued. The key performance indicators of our nanobolometer such as detection bandwidth, dynamics range, and sensitivity will be compared with the existing room-temperature technology and a potential market share for our nanobolometer will be mapped. Especially, the opportunities for commercial systems already utilizing cryogenic components such as superconducting filters at cellular phone base stations will be investigated. During this ERC PoC project, also other business opportunities will be studied and possibilities for founding a spin-out company will be actively sought for.

Keywords: condensed matter physics,bolometer,microwave,spectrum analyser,superconductor,cryoelectronics
Chloroplast and Mitochondria interactions for microalgal acclimation (ChloroMito)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-01-01
End date: 2025-12-31
Duration (months): 72.0
Total project cost (EUR): 2498207.0
EU funding (EUR): 2498207.0
Participants: 2
Project status: SIGNED

Photosynthesis emerged as an energy-harvesting process at least 3.5 billion years ago, first in anoxygenic bacteria and then in oxygen-producing organisms, which led to the evolution of complex life forms with oxygen-based metabolisms (e.g. humans). Oxygenic photosynthesis produces ATP and NADPH, and the correct balance between these energy-rich molecules allows assimilation of CO2 into organic matter. Although the mechanisms of ATP/NADPH synthesis are well understood, less is known about how CO2 assimilation was optimised. This process was essential to the successful phototrophic colonisation of land (by Plantae) and the oceans (by phytoplankton). Plants optimised CO2 assimilation using chloroplast-localised ATP-generating processes to control the ATP/NADPH ratio, but the strategies developed by phytoplankton are poorly understood. However, diatoms—ecologically successful ocean organisms—are known to control this ratio by exchanging energy between plastids and mitochondria. Is this mechanism a paradigm for optimisation of photosynthesis in the ocean? The ChloroMito project aims to first decipher the mechanism(s) behind plastid-mitochondria interactions. Thanks to a novel combination of whole-cell approaches, including (opto)genetics, cellular tomography and single-cell spectroscopy, we will identify the nature of the exchanges occurring in diatoms and assess their contribution to dynamic responses to environmental stimuli (light, temperature, nutrients). We will then assess conservation of this mechanism in ecologically relevant phytoplankton taxa, test its role in supporting different lifestyles (autotrophy, mixotrophy, photosymbiosis) encountered in the ocean, and track transitions between these different lifestyles as part of an unprecedented effort to visualise ocean dynamics. Overall, the ChloroMito project will alter our understanding of ocean photosynthesis, challenging textbook concepts which are often inferred from plant-based concepts

Keywords: acclimation of photosynthesis