Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nuclear pores and chromatin organization: a crosstalk? (NCOre)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1875000.0
EU funding (EUR): 1875000.0
Participants: 1
Project status: SIGNED

Chromatin organization plays a crucial role in regulating DNA-related processes such as transcription, replication, and repair. In most somatic cells, heterochromatin localizes at the nuclear periphery while euchromatin is broadly distributed within the nucleus. This spatial organization is believed to mostly rely on the association of heterochromatin with the nuclear lamina, which in turn participates in gene repression. In a striking contrast, the nuclear pore vicinity is always devoid of heterochromatin, therefore forming heterochromatin exclusion zones within the heterochromatin layer of the nuclear periphery. In rupture with the classical view that the nuclear lamina stands as the main determinant of heterochromatin accumulation at the nuclear periphery, I propose that it rather results from an equilibrium between attraction at the nuclear lamina and exclusion from the adjacent nuclear compartment: the nuclear pores. I further propose that by excluding heterochromatin, nuclear pores participate in global chromatin organization, and thereby impact gene regulation. Whether the absence of heterochromatin at nuclear pores impacts their function is unknown. Using a combination of advanced microscopy techniques, proteomics and genomics, I will interrogate the crosstalk between nuclear pores and chromatin organization by addressing three fundamental questions: (1) What is the contribution of heterochromatin exclusion zones to global chromatin organization? (2) What are the mechanisms underlying heterochromatin exclusion zone maintenance at nuclear pores? (3) What is the role of heterochromatin exclusion in nuclear pores transport? The NCORe project therefore promises to shed light on new mechanisms regulating chromatin organization and nucleocytoplasmic transport.

Keywords: heterochromatin,nuclear pores,lamina associated domains
Marine microfossil networks: ancient and future community dynamics at the base of the food chain (BUGNET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Marine communities are becoming increasingly disrupted due to anthropogenic climate forcing. These changes are typified by biogeographic range shifts, global biomass declines, community restructuring, and detrimental biological modifications and alterations to organism functionality. It is therefore increasingly pertinent to understand how global marine communities will respond as climate continues to change, and to identify potential tipping points in marine biodiversity which may trigger the collapse of ecosystems beneficial to the livelihood and nutrition of billions of people around the globe. In the modern ocean, the biodiversity distribution of the single-celled protists, the planktonic foraminifera, matches that of organisms fundamental to human populations, such as tuna, squid, and billfish. Novel studies employing networks on the unmatched fossil record of the planktonic foraminifera indicate an equatorward shift in functional communities during the last 8 million years, due to global cooling, whilst other observations now suggest species populations have already begun to shift poleward from their pre-industrial distributions. This poleward shifting may suggest entire food webs may shift poleward, or collapse altogether. We will expand these novel network applications within the planktonic foraminiferal fossil record by applying these methods to all microplankton records (coccolithophores, radiolarians, diatoms, dinoflagellates) to determine the nature of these community shifts to late Cenozoic climate changes. Following this, we will then assess and compare the community patterns of the Last Glacial Period and the pre-industrial Holocene records to determine the abiotic drivers of these distributions. Finally, using ocean models of multiple anthropogenic emission scenarios, we will determine how the structure of global communities may become altered in the near future.

Keywords: functional,communities,networks,climate models,climate scenarios
Innovative eco-smart shower device for enhanced safety and autonomy of elderly and disabled individuals (ECO-SHOWER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: SIGNED

Society has long overlooked the needs of individuals with dependencies and disabilities, particularly during daily activities like showering, which can be stressful and unsafe. Dependent individuals, including those with physical, mental, and sensory disabilities, face significant challenges. Showering poses safety risks, especially for the elderly, as falls in bathrooms are common and can cause severe injuries. Caregivers also experience physical and emotional strain, often exacerbated by suboptimal caregiver-to-patient ratios. Showee is an innovative eco-smart shower device designed to address these challenges, enhancing safety, autonomy, and user experience for elderly and disabled individuals. It features dual water/soap outlets, air drying, an intuitive touchscreen interface, adjustable height, a virtual assistant for guidance, and mobile app integration. Showee conserves water through automated temperature control, significantly reducing consumption by up to 50%. New features include voice control, chromotherapy, music therapy, and safety measures like fall detection. Showee's development involved extensive user testing and collaboration with various institutions. It offers unique advantages such as efficient soap mixing, height adjustability, and ease of installation. As societal awareness of accessibility issues grows and environmental concerns become urgent, Showee’s market entry is timely. It promises substantial improvements in quality of life for dependent individuals and their caregivers, fostering greater independence, safety, and well-being.

Keywords: eco shower,smart shower,accessible shower,disabilities,wellness,health care,caregivers,dependency,elderly
Antimicrobial nano-coatings for hospital textiles to prevent the spread of healthcare associated infections (NANO-PROTECT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

The main objective of NANO-PROTECT is to develop innovative antibacterial, antifungal, antiviral, and anti-biofilm (4A) nano-enabled coatings for medical textiles, upholstery fabrics, and personal protective equipment (PPE) which would be susceptible to pathogens contamination in hospitals. This proposal will focus on designing a pallet of antibiotic-free nanocomposites for coating medical textiles. Novel inorganic nanoparticles with broad antimicrobial activities comprising antibiotic-resistant strains and viruses will be fabricated. The designed nanoparticles will be used for fabricating nano-enabled inorganic/bio-based composites comprising different mechanisms of anti-biofilm and antimicrobial activities. The durability of the antimicrobial function will be monitored by visual indicators. Safer water-based sonochemistry, bio-based metal reduction, self-assembling, enzymatic crosslinking, and a combination thereof would be employed. Moreover, versatile high-precision technologies for nanometric coatings (spray coating, and ink-jet printing) will be tested with a lower quantity of NPs requirements. Further, single-step sonochemical fabrication and coating will be evaluated to make “ready-to-use” products with nano-structured antimicrobial surfaces. Therefore, NANO-PROTECT's nanotechnology-based solutions will provide environmental health safety for patients, visitors, and professionals.

Keywords: nanocoatings,textiles,nanomaterials,healthcare associated infections
Mycelium-based packaging on an automated industrial scale (BIOPAK)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Polystyrene, a mainstay in the packaging industry, poses significant environmental challenges. It is non-recyclable and takes over 500 years to degrade, lingering in landfills indefinitely. Annually, the production of 15 million tons of polystyrene results in 105 billion kilograms of CO2 emissions and 180 billion liters of water usage, constituting 30% of global landfill content. Despite growing demand for sustainable packaging, only 1.5% is currently made from alternative materials, which are often more expensive, not fully biodegradable, and lack industrial scalability. We have developed a groundbreaking technology, currently covered by 5 pending EU patents, to produce mycelium-based packaging at an industrial scale. Our packaging is 100% biodegradable and landfill-free, custom-designed for versatility, thermal insulation, and waterproofing. It is suitable for a wide range of applications, from cushioning cosmetics and electronic lodgements to packaging for decor, fashion, and thermally insulated boxes for food and pharmaceuticals. Our pioneering industrial process technology for manufacturing biodegradable packaging has achieved TRL 6 and has been demonstrated with industrial leader’s partners. We will operate under a dual-revenue B2B model by selling Packaging first and then the technology in Mini-factory Service Monthly Fees. We target the large segments of the Rigid Foam Packaging and partially Molded Pulp Packaging markets in Europe projected to grow from €10 billion in 2024 to €14 billion in 2030, with a CAGR of 6%. We aim to capture 2.5% of the market share by 2030, significantly reducing non-biodegradable waste and saving worldwide landfill space. The EIC's financial support is essential to cover the substantial final developments costs needed to elevate our pioneering manufacturing technology to TRL 9 and expand internationally.

Keywords: packaging industry,manufacturing technology,mycelium based packaging
LEarning VEntuReS for Climate Justice (LEVERS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Ireland,Belgium,Cyprus,United Kingdom,Portugal,Serbia,Slovenia,Switzerland,Greece
Call: Open schooling for science education and a learning continuum for all (HORIZON-WIDERA-2022-ERA-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 1513997.0
EU funding (EUR): 1513997.0
Participants: 12
Project status: SIGNED

We live in an increasingly fragmented and unequal society. Democracy is in crisis, and mistrust in science is on the rise, yet the unprecedented challenges we face, such as the climate and biodiversity crises, require greater scientific literacy and engagement across society. Education needs to provide the scientific knowledge to engender engaged and informed societies, but also to equip learners with the holistic competences to support and motivate them to become courageous thinkers and doers, actively shaping their own futures. We urgently need connected, system-wide responses that incorporate varied perspectives, are empathetic to different stakeholders’ needs and centre social justice and care. To achieve this, we need models for education that are more flexible and inclusive and advance lifelong learning to empower all citizens. LEVERS delivers Learning Ventures, a replicable model for expansive science learning through multi-stakeholder regional partnerships that collaboratively explore challenges and design science learning experiences to address local issues. In 9 Learning Venture demonstrator regions, stakeholders from formal, non-formal and informal education across education levels, community organisations, research and innovation, industry, and government, will be supported to adopt a systemic design approach to create climate justice projects offering meaningful real-world learning experiences. Capacity building and a mentoring programme will offer role models and guidance within and between regional Learning Ventures, linking R&I with education. The LEVERS Learning Framework and Field Guide will enable the partnership model to be adapted for other regions and challenges. Professional learning programmes and Open Schooling resources will enable widespread uptake from youth and adult educators. Guides for industry engagement, business models and policy recommendations will ensure transformative impact on science education in Europe into the future.

Keywords: learning ecosystems,climate education,climate justice
Cardiogenomics meets Artificial Intelligence: a step forward in arrhythmogenic cardiomyopathy diagnosis and treatment (IMPACT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Netherlands,France,Portugal
Call: EIC Pathfinder Challenge: Cardiogenomics (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 4234337.24
EU funding (EUR): 4234337.24
Participants: 9
Project status: SIGNED

Arrhythmogenic cardiomyopathy (ACM) is a genetic disease characterized by progressive cardiomyocyte loss and fibrofatty replacement, which in turn lead to the occurrence of ventricular arrhythmias and sudden cardiac death (SCD), particularly in the young and athletes. At present, ACM is uncurable; with an incidence of 1:5000, it can be considered a major CVD disease. The subform involving only the right ventricle is the most common; the majority of its causative mutations are identified in just three desmosomal genes: PKP2, DSP, and DSG2. However, many of the identified variants in these disease genes are still of uncertain clinical significance (VUS) and thus of limited clinical utility. The overall aim of the project is to combine large-scale data from genomics, proteomics and instrumental analysis obtained from patients with data from structural and functional analyses of in vitro (3D microtissue) and in vivo (murine) models, to establish the genotype/cardiac phenotype relationship, potentially leading to a better understanding of the role and impact of known genes and epigenetic factors (ie, miRNAs) on susceptibility, clinical progression, and treatment of ACM. The project’s outcomes will pave the way towards novel therapies for ACM.

Keywords: characterization of variant of uncertain clinical significance,cardiac microtissues,artificial intelligence driven analyses of high throughput screening
Towards Evidence-based Policies for Safe and Sound Robots: Harnessing experimentation to optimize the regulatory framing of healthcare robot technologies (SAFEandSOUND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1499308.0
EU funding (EUR): 1499308.0
Participants: 1
Project status: SIGNED

GOAL This project aims to make healthcare robots safe and sound for society. PROBLEM STATEMENT There is an increasing gap between the policy cycle's speed and technological change. This gap is very noticeable in healthcare robotics, where policies are scattered and cover the issues robots entailed unevenly. This disconnect results in robot developers failing to integrate essential legal considerations into their designs, user safety not always being ensured, and the development of systems that may cause harm to patients. While other sectors enjoy evidence-based policies that translate policy goals into practical guidance, these frameworks have yet to emerge for robotic technology. RESEARCH OBJECTIVES SAFEandSOUND has the ambition to connect the policy cycle with data generated in robot testing zones to support evidence-based policymaking for robot technologies. The project examines regulatory gaps for robots from different sources (literature, policy, and patient engagement), tests these issues in experimental zones, investigates how to generate policy-relevant data from such experimentation, and uses it for policy change, design requirements, and a charter for user rights. METHODS SAFEandSOUND's overarching methodology is anticipatory regulation, an emerging, proactive, iterative legal approach for empirically framing fast-evolving technological changes. SAFEandSOUND uses robot testbeds, open data, interaction between regulators and developers, and active patient engagement to support regulators' proactive, engaged role in the healthcare robot innovation process. SCIENTIFIC CONTRIBUTION SAFEandSOUND advances research toward an evidence-based regulatory model for robots that guides rather than catches up with robot (r)evolution and is more attuned to societal needs and fundamental rights. SAFEandSOUND opens new avenues for using evidence-based mechanisms to regulate robots in the EU and serves as an example for such activities across the globe.
ENhanced AI-baSEd cybercriMe-oriented collaBorative investigation technologies and capabiLitiEs (ENSEMBLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Research and Innovation actions
Countries involved: Greece,Ireland,Romania,France,Portugal,Spain,Moldova, Republic of,Switzerland,United Kingdom,Italy,Netherlands,Austria
Call: Enhancing tools and capabilities to fight advanced forms of cyber threats and cyber-dependent crimes (HORIZON-CL3-2023-FCT-01, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 3663146.25
EU funding (EUR): 3663143.0
Participants: 18
Project status: SIGNED

Technology advancements enhance everyday life, but they also provide numerous opportunities for the proliferation of advanced cybercrimes, which, via innovative tactics and techniques, pose serious security and financial risks to EU and beyond. ENSEMBLE aims to provide a well-rounded response to the fight against (cross-border) cybercriminal activities, at the nexus of advanced AI-based technological solutions, (multi-stakeholder) investigations processes, training, and awareness in order to detect and prevent cybercrime-related activities, with particular focus on ransomware, cyber fraud, data theft and extortion as well as unauthorised access and crypto-jackings. This will be achieved via a three-pillar approach. ENSEMBLE will develop a modular AI-based, forensically sound investigation toolbox based on user centric criteria, to assist Police Authorities in detecting, extracting, processing, and analysing online information relevant to cybercrime activities, thus fighting sophisticated cyber-threats, capitalising also in joint multi-stakeholder operations both at national and cross border level and in secure data and information sharing mechanisms. Police Authorities, prosecutors, and judicial actors involved in such investigations will be offered innovative training curricula and methods as well as synchronous and/or asynchronous learning methodologies that will be aligned to their needs and improve their current capacity, taking into consideration the technological, procedural, operational, legal/multi-jurisdictional dimensions. Finally, public awareness and engagement with relevant actors for early identification and prevention of cybercrimes will be cultivated through targeted awareness raising campaigns and specific policy recommendations. Having brough together a multidisciplinary team of five LEAs, seven research/academic institutions and six industry partners (including five SMEs) with a wide range of expertise in the field, ENSEMBLE provides a compelling

Keywords: ai based,modular toolbox,ransomware,data theft,illicit activities,crypto assets