Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MyoNanoCell: CardioMYOgenic NANOsized CELL-based Vehicles for Cardiac Microenvironment Modulation and Heart Fibrosis Therapy (MyoNanoCell)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Cardiovascular diseases are the leading cause of death worldwide, accounting roughly for 45% of all deaths in Europe and costing billions of euros to the European Union economy. Among these, most cardiovascular diseases, such as myocardial infarction, lead to the formation of heart scarring, which is the formation of fibrotic tissue that impairs contractility and cardiac function, ultimately causing heart failure. Despite the prevalence and serious consequences of heart fibrosis, current benchmark therapies have low long-term efficacy, and alternative novel therapies that have reached clinical testing still present severe limitations or lead to little improvement in cardiac function. Thus, there is still an urgent unmet need for the development of novel and efficient therapies for cardiac fibrosis. Cutting-edge research regarding the use of stem cells or delivery of molecules to induce cardiomyocyte proliferation are yet to be successful, as most of these therapies present challenges regarding immunogenicity, efficiency, and long-lasting effect. Thereby, MyoNanoCell project aims at developing a radically new platform for heart fibrosis and cardiac regeneration. By using a combinatory approach, where the MyoNanoCell nanohybrids incorporate not only the ability to carry different cardiomyogenic molecules, but also the ability to modulate the cardiac microenvironment and recognize cardiac fibroblasts, MyoNanoCell will radically increase therapeutic efficiency. Moreover, the simultaneous modulation of cardiac microenvironment and its repopulation with cardiomyocytes by fibroblast reprogramming will directly impact contractility and heart function, representing a paradigm shift in cardiac fibrosis therapy. MyoNanoCell will be fully characterized in vitro to have a full biological fingerprint on the process of cell identity shift, and also tested in advanced 3D in vitro models, to evaluate its overall effects at tissue level.

Keywords: nanomedicine,nanoparticles,nanohybrids,cardiovascular drug delivery,fibroblast reprogramming,cardiac fibrosis,cardiovascular diseases
Formation and high-resolution spectroscopic characterization of carbonic acid (HRMSCA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

The main greenhouse gases in our atmosphere are water and carbon dioxide. Much attention is given to the study of the physicochemical properties of these molecules. However, there are no studies aimed at studying the formation of carbonic acid from these molecules in the atmosphere. The objective of this project is to analyze the development of carbonic acid (H2CO3) and its possible formation from CO2 and H2O in the gas phase. It is anticipated that the aggregation and large vibrational excitation will favor the conversion of the CO2-H2O complex into H2CO3. To test this theoretical prediction, our project will employ a distinctive combination of supersonic expansion, mass spectrometry, intracavity infrared excitation, and microwave sensing.

Keywords: high resolution molecular spectroscopy cavity ring down spectroscopy chirp pulse microwave spectroscopy supersonic expansion van der waals complexes carbonic acid
EU ADVISORY NETworks to reduce the use and risks of PESTicides. (AdvisoryNetPEST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Portugal,Spain,Austria,Latvia,Bulgaria,Croatia,Denmark,Netherlands,United Kingdom,Hungary,France,Greece,Poland,Belgium
Call: Developing EU advisory networks to reduce the use of pesticides (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 4212279.74
EU funding (EUR): 3786986.15
Participants: 19
Project status: SIGNED

The EU Farm to Fork strategy, which is at the heart of the European Green Deal, aims to make food systems fair, healthy, and environmentally friendly. To achieve the objectives of the Farm to Fork strategy, the Commission proposed, among other, new targets to reduce the use and risks of pesticides (RURP). The main objective of AdvisoryNetPEST is to establish and upgrade a network of advisory services across the EU, increasing the knowledge sharing between advisors, and among the whole AKIS, and the adoption of innovative solutions to RURP by farmers. The project will achieve this by: 1) Developing a EU network of advisors to RURP, based on existing networks and national AKIS, covering the 27 EU Members States (MSs) and the UK. To cover all MSs, the project will adopt a twinning approach: 14 National Networks will be created by the project partners, and these will engage with 14 Associated Networks through a twining program. The network will cover all European pedo-climatic areas, integrating four EU regional clusters and the most relevant crop sectors. 2) Identifying, selecting, and shaping Novel Approaches (NAs), which are technically, economically, socially, and environmentally viable, that will be adapted and replicated across the EU. 3) Exchanging knowledge and training advisors and students to promote the adoption of the NAs. 4) Connecting the project with other national and EU projects, initiatives and policy makers. 5) Scaling up the NAs, fostering the adoption of innovative solutions by farmers and the whole value chain. The project will embrace a multi-actor approach, gathering 19 partner organisations with a vast experience in advisory and crop protection. The consortium will also represent a diversity of AKIS stakeholders, including advisors, researchers, and other value chain actors, as the cornerstone of a regional, national, and EU level network that will allow a wide sharing of technical and practical expertise to RURP in the long-term.

Keywords: pesticides,network,advisory,reduction,use,risks,novel approaches
Multi-actor collaboration dynamics and capacity building network inside and between AKIS to foster the upscaling of SFSCs across Europe (EU4Advice)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Netherlands,Hungary,Germany,Ireland,Belgium,Austria,Spain,France,Italy,Czechia,Romania,Norway,United Kingdom
Call: Developing EU advisory networks on consumer-producer chains (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 3809059.25
EU funding (EUR): 3809059.25
Participants: 23
Project status: SIGNED

In line with the new CAP post2020, the F2F Strategy and the Green Deal, the EU4Advice Project will develop enabling methodologies and tools to connect short food supply chains (SFSCs) advisors in a common network with the aim of fostering the upscaling of consumer-producer chains across Europe. SFSCs are a mean for producers to increase their bargaining power and to improve their position within the value chain and for consumers to increase trust, transparency, quality and safety of their food. Political and socio-economic barriers and gaps need to be addressed in order to enhance the scope of consumer-producer chains across Europe and EU4Advice will provide the necessary tools to the relevant stakeholders to overcome them. One key challenge to achieve this goal is to improve national AKIS by implementing new governance models that facilitates the integration of SFSCs advisory services Through a multi-actor approach involving advisors, policy makers, researchers, farmers and consumers, and by implementing a living lab methodology, EU4Advice will create the foundations for the establishment of a network of SFSC-advisors across Europe that will be appropriately structured and connected to a diversity of stakeholders within the national AKIS. The development of networking tools, contents for SFSCs advisors, a tailored dissemination, communication and exploitation strategy, and impact assessment plans will create the appropriate ecosystem for the effective transfer of knowledge among stakeholders in the 27 EU members. Based on previous key related multi-actor projects, EU4Advice will apply the “GAIN transition model” to guide the successful implementation of the multi-actor network through different administrative levels: local, regional, national and European. EU4Advice will establish appropriate channels for collaboration and knowledge exchange among a selected group of multi-actor projects, thematic networks and focus groups at EU level, to ensure a long term impact

Keywords: akis,cap strategic plans,short food supply chains,advisors,policy makers,living labs,primary producers,sustainable food systems,farmer empowerment,rural development programme
Mesoscale dissection of neuronal populations underlying cognition (MESO_AG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The brain is responsible for cognition, broadly defined as thinking, by combining mental processes such as sensory integration, perception, and working memory. One of neuroscience’s major challenges is understanding how the brain encodes cognition as a whole. The biggest obstacle to this goal is the complex nature of the brain, which contains billions of entangled neurons that form a dynamic, ever-changing network. We propose to use the mouse model to study cognitive processing streams across the brain. By applying a zoom-out/zoom-in approach, we first study cognition at the mesoscale level (i.e., the population level across many areas) and then zoom in and dissect a specific sub-population. Importantly, we focus on the dynamic brain-wide networks of different cognitive functions that are modulated within single trials and in each individual mouse. We hypothesize that cognitive functions are encoded at the mesoscale level in which information flexibly flows across many brain areas, but with certain motifs and rules. Each objective targets one processing stream and one cognitive function: streams within one cortical hemisphere during sensory integration, streams across cortical hemispheres transferring working memory, and streams between cortex and sub-cortex during perception. In each work package, we will train mice in cognitive behavioral paradigms, and perform a zoom-out/zoom-in protocol with the same mouse. First, we will implement a mesoscale approach (e.g., wide-field imaging and/or multi-fiber photometry) to outline the processing stream within the cognitive network. Second, we will zoom in to dissect a specific node or edge using multi-area two-photon microscopy, labeling techniques, and optogenetics. Importantly, these work packages are modulatory and with substantial overlaps, enabling us to obtain a brain-wide cognitive map that will aid in understanding cognition as a whole in both the healthy and the diseased brain.

Keywords: wide field imaging in mice mouse whisker system working memory perception sensory integration cortical large scale dynamics
My Awesome Research Is for Everyone! (MARIE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Greece
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-04-01
End date: 2024-01-31
Duration (months): 22.0
Total project cost (EUR): 298962.5
EU funding (EUR): 298962.5
Participants: 6
Project status: CLOSED

MARIE (My Awesome Research Is for Everyone!) is the Greek proposal that brings together six of the country's most prestigious academic/research organisations to host Researchers’ Night Events in the years 2022 and 2023. These organisations will hold, each year, six ERN events in four cities of the mainland (Athens, Thessaloniki, Patras, Larissa) and two cities of the island of Crete (Heraklion and Rethymnon). The events will cover the Greek territory from north to south, inviting more than 70% of the population to live the European Researchers' Night events. Before the Nights, through a carefully designed, multichannel, awareness campaign, MARIE will spread the ERN messages nationwide, highlighting the high-quality research conducted in Europe and its importance for our everyday lives. With a mix of traditional and modern marketing tools, an extensive network of collaborators and the availability of hundreds of researchers, MARIE's ambition is to get into the households of two million citizens inviting them to the Nights. In addition, researchers visit schools and talk to students igniting scientific curiosity and an interest in pursuing a research career. Furthermore, MARIE organizes the “Chat lab”, online meetings of researchers with teachers and students who reside in remote areas, providing them with the opportunity to meet researchers and learn about the fascinating world of science. During the Nights, an array of activities, mostly led by researchers of different career stages and profiles, is foreseen. Exhibitions with hundreds of technological products, hands-on experiments, scientific demonstrations, activities designed specifically for kids combined with various entertaining activities will allow visitors to delve into the amazing world of research. Thanks to the size of the cities, the carefully selected venues, the thorough awareness campaign and the appealing programme of the Nights, MARIE expects to receive more than 24.000 visitors at its events.

Keywords: research,science,education,entertainment,edutainment,events,public,students,greece,athens,thessaloniki,larissa,patras,heraklion,rethymnon
Multi-scale and Multi-physics Modelling of Soft Tissues (MULTI-SOFT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 3
Project status: CLOSED

Mechanics exerts significant influence on biological growth, development, and disease through multi-physical factors and at multi scales. Current modelling research in cancer growth, spreading and morphogenesis lags far behind experimental studies, and this gap has seriously hindered cancer diagnosis and treatment. The advanced mathematical and computational modelling of soft tissue and cancer-related phenomena, combined with systematic experimental studies and robust numerical simulations, are of great research significance to the health and economic values of Europe. The main goal of the MULTI-SOFT project is to overcome these challenges in an original and innovative manner by developing multi-scale and multi-physics modelling of soft tissues to improve our understanding of cancer and develop tools for its identification and treatment. The work will be approached from theoretical, computational, and experimental perspectives based on the applicant's and host laboratory's expertise. The training program is exhaustive and will allow the applicant to grow as an independent researcher. The proposed research will foster further development in this direction, a step that is fundamental in healthcare and for the benefit of society. The applicant is a Chinese scholar with expertise in the areas of applied mathematics, solid mechanics, soft matter, instability and bifurcation, and multi-filed coupling. He has been trained in prestigious academic institutions in China, Ireland, and the UK. He publishes articles in high-impact factor and top journals, at the frontiers of applied mathematics, biomechanics, and other disciplines. He is requesting funds for two years, to work with Prof. Davide Bigoni and his Solid and Structural Mechanics Group at the University of Trento, Italy, and secondment (six months) at the Graz University of Technology, Austria, and the International School for Advanced Studies, Italy.

Keywords: soft tissues,gel,cancer,multi physics,multi scale,volume growth,morphogenesis,viscoelasticity,instability and bifurcation,discrete model,finite element simulation,experimental techniques
Origins and Consequences of Hematopoietic Stem Cell Memories (MemOriStem)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Hematopoiesis has long been modeled as a stepwise hierarchical process, where all blood cells arise from a single group of rare multipotent stem cells. For decades, various reports have contested this unifying paradigm, indicating that hematopoietic stem cells are functionally heterogeneous and differ on the rates and types of blood cells that they produce. However, the origins of stem cell heterogeneity and, importantly, its physiological consequences have remained ambiguous. My recent research suggests that individual stem cell behaviors are deterministic and programmed through long-lasting epigenetic memories, but how these different stem cell memories arise during development or injury is currently unknown. Intriguingly, my preliminary results indicate that stem cell memories instruct not just their fate decisions but also the functional properties of their mature progeny, thus raising the question of how stem cell memories create functional patterns that bias the cellular responses of their mature progeny. Thus, the objectives of MemOriStem are: (1) to uncover the mechanisms that establish the diversity of HSC memories during development; (2) to identify the molecular determinants that maintain specific HSC properties; and (3) to characterize how developmental and acquired HSC memories determine functional patterns in mature blood cell responses. To overcome various challenging aspects of studying cell memories in vivo, I have designed a ground-breaking approach that combines innovative mouse models for transient gene silencing, multiplexed clonal analysis, and molecular recorders of cellular states. In sum, MemOriStem will precisely define the origins, mechanisms, and physiologic consequences of hematopoietic memories, thus allowing a conceptual leap forward in regenerative and stem cell biology. Harnessing the programming of stem cell memories may help in the development of in situ cell therapeutics to treat chronic inflammation, aging, and cancer.

Keywords: hematopoietic stem cells functional heterogeneity cell memory in vivo crispr single cell analysis cell barcoding clonal analysis lineage tracing myeloid heterogeneity
INNOVATIVE BUSINESS MODELS FOR SOIL HEALTH (NOVASOIL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Latvia,Bulgaria,Italy,Netherlands,Estonia,United Kingdom,France,Denmark
Call: Incentives and business models for soil health (HORIZON-MISS-2021-SOIL-02, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 4388915.0
EU funding (EUR): 4388914.75
Participants: 16
Project status: SIGNED

The general objective of NOVASOIL project is highlight the benefits for the society and the environment from the investment in soil health. The main expected outcome of the project is a toolbox for the analysis of suitability of different business cases that promote soil health. This toolbox will be based on a set of good examples from Europe and other countries and the needs and demands from the society. The toolbox will include a categorisation of the models and business cases taking into account: a) sustainable soil management under different land uses and climatic conditions; b) products based on practices promoting soil health; c) consumption and certification practices conductive: d) the reuse of land and e) sustainable soil management in the context of the EU Taxonomy Regulation. For that, NOVASOIL is composed by a multidisciplinary team with a large experience on European and national projects focus on soil health and business models. As well as, NOVASOIL will built a Community of Practice around project objectives in order to co-develop soil health business models and the tool-box for incentives taking into account their needs and demands. NOVASOIL is organised in 5 WPs plus coordination following the expected objectives and impacts of the call. The first step is to develop a conceptual framework of soil health and business. This framework will nurture other WPs in order to develop in the same way all the expected objectives. The soil health business models will analyse current successful experiences in Europe and outside Europe in order to categorise them taking into account their variability. In addition, NOVASOIL includes 13 Case Studies with business models that promote soil quality and products based on sustainable crop and soil management. On the other hand, an analysis of current policies related will be carried out in order to provide suggestions and improvement that facilitate the implementation of these soil health business.

Keywords: soil health