Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Gain by Strain: Precise Cuts of Cyclopropanes as Key to Molecular Complexity (GAINBYSTRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1994250.0
EU funding (EUR): 1994250.0
Participants: 1
Project status: CLOSED

A central discipline of chemistry is the design und creation of molecules with defined structural and chemical properties. Stretching synthetic horizons is a never-ending endeavor to inspirit the chemist’ s creativity in preparing compounds and materials yet to be discovered. Relying on their high strain energy cyclopropanes, as carriers of the most fundamental ring geometry, offer a unique reactivity which allows for a multitude of transformations being grouped in ring-opening reactions, cycloadditions and rearrangements. Major advantage of all these processes is the cyclopropane-derived intrinsic atom-economy. In this research project, we propose a number of uncommon and challenging reactions making use of donor-acceptor cyclopropanes. Introducing a distinctively controlled bond cleavage we seek to develop novel modes of 1,3-bifunctionalization by σ-bond metathesis, by using hypervalent iodine reagents and by merging organocatalysis with photoredox catalysis. Unprecedented ring-enlargements to four-membered rings by [3+1]-cycloadditions employing isonitriles, carbenes and nitrenes are envisioned, aryne insertions into the three-membered ring leading to indane systems are planned and a general concept for [3+3]-cycloadditions with 1,3-dipoles is presented paving the way to unusual syntheses of heterocycles. A distinct class of compounds obtainable by our methodology will set the stage to access completely unexplored heterocyclic π-systems being of interest for material science and molecular electronics. Besides our central goals of advancing organic methodology and to demonstrating the synthetic utility of these novel reactions, we anticipate that mechanistic insights gained by experimental and computational means will be of high impact for the chemistry of this fundamental structural unit in general.

Keywords: cyclopropanes,donor acceptor cyclopropanes,organic methodology,strained systems
Overweight-induced Hypogonadism as major factor for the generation and/or perpetuation of Metabolic Co-morbidities of Obesity: Contribution of Epigenetic Regulatory Mechanisms (ReprObesity)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Obesity is a global health problem whose prevalence is increasing substantially due to lifestyle changes. This complex medical condition is frequently linked to serious metabolic complications and deregulation of hormonal axes, which lead to perturbed homeostasis in conditions of overweight. Different studies have suggested that obesity is often associated to hypogonadism, a reproductive disorder that might also promote metabolic alterations, thus setting a vicious circle in the generation/perpetuation of obesity co-morbidities. While the targets and molecular mechanisms underlying this phenomenon are still unknown, emerging evidence from experimental models of metabolic stress linked to hypogonadism strongly suggests the potential role of perturbations of hypothalamic Kiss1/NKB neurons. Likewise, the recently identified involvement of epigenetics in the control of Kiss1 expression at puberty, a crucial stage in sexual development that is metabolically gated, suggests also the contribution of these regulatory mechanisms to this phenomenon. In this context, this project aims to elucidate the pathophysiological relevance of epigenetic regulatory mechanisms in obesity-induced hypogonadism and their influence in the generation/ maintenance of the metabolic complications of overweight. To this end, we will characterize the time-course of alterations of key hormonal and epigenetic factors in preclinical models of obesity and will evaluate the contribution of epigenetic modifications in deregulation of hypothalamic Kiss1/NKB neurons in conditions of overweight. In addition, we will analyse the potential role of gonadal steroids in this phenomenon. This project will help to identify the molecular targets and epigenetic mechanisms responsible for the metabolic perturbations linked to obesity-induced hypogonadism, and will aid to define better tools for the treatment of these complications.

Keywords: health sciences,neuroendocrinology,metabolism,obesity,reproduction,epigenetics,kiss1,hypothalamus
Continuous Blood Glucose Monitoring and automated therapeutic closed loop medical device for Intensive Care Units (ContiTRACE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Intensive Care Units (ICUs) require careful monitoring of blood glucose levels and insulin infusion to keep patients within safe physiological levels. Fluctuations of blood glucose are directly related to an increased risk of death and comorbidities. However, blood glucose monitoring (BGM) is still made by intermittent and manual offline analysis of blood samples. This technique proves inefficient (need 17% caregivers time), costly (€300 per patient) and increments mortality in hospital ICUs by 40% due to irregular glucose level adjustments upon measurements. After 15+ years of experience in developing glucose monitoring sensors, we at TRACE are taking on our next big step to penetrate the medical device sector with ContiTRACE: an AI powered automated non-invasive medical device for continuous BGM. Our patented ContiTRACE is able to measure glycaemic levels every 2 minutes (automatically) and automatically infuse insulin when needed. It is also capable of self-calibrating and has standardized body accesses, enhancing safety and minimising discomfort for the ICU patient. This will allow 1) caregivers to decrease their workload, 2) doctors to take informed decisions and 3) the healthcare system to optimize their limited human, economic and material resources by providing savings of more than 50% of BGM related cost. Our business model is twofold. We will sell the medical device (5 years lifecycle), and the consumables (max. 4 days duration per set) to private and public hospital ICUs. Our draft forecast (2022-2026) estimates profits of 14.4 M€ with a Return on Investment of 10.7 by the 5th commercial year allowing us to increase x10 our company headcounts in five commercial years. Although newcomers to the medical sector we have the support of key players among regulatory companies (Profil), manufacturers (Sasse Elektronik), pharma companies (Sanofi-Aventis, Pfizer and Roche) and distributors (Care Diagnostica) to take on the BGM challenge.

Keywords: intelligent blood glucose monitoring,monitoring of intensive care unit patients,critically ill patients,clinical support decision tool for blood glucose monitoring
Enhanced NeUtrino BEams from kaon Tagging (ENUBET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy,Italy
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2022-11-30
Duration (months): 78.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 957605.0
Participants: 2
Project status: CLOSED

ENUBET has been designed to open a new window of opportunities in accelerator neutrino physics. The proposed project enables for the first time the measurement of the positrons produced in the decay tunnel of conventional neutrino beams: these particles signal uniquely the generation of an electron neutrino at source. Neutrino facilities enhanced by the ENUBET technique will have an unprecedented control of the neutrino flux. This will allow to reduce by one order of magnitude the uncertainties on neutrino cross sections: a leap that has been sought after since decades and that is needed to address the challenges of discovering matter-antimatter asymmetries in the leptonic sector. The apparatus is a highly specialized electromagnetic calorimeter with fast response, sustaining particle rates as high as 0.5 MHz/cm^2, having excellent electron/pion separation capabilities with a reduced number of read-out channels. ENUBET will boost technologies that have been envisaged for high energy colliders to address this new challenge. On the other hand it will operate in a substantially different configuration. The experiment will be performed at the CERN Neutrino Platform, a recently approved facility where innovative neutrino detectors will be developed exploiting dedicated hadron beam-lines from the SPS accelerator. In the first phase of the project, ENUBET will address the challenges of particle identification from extended sources, developing innovative optical readout systems and cost-effective solutions for radiation imaging. This approach is based on cutting-edge technologies for single photon sensitive devices. During the second phase, the detector will be assembled and characterized at CERN with particle beams. Finally, it will be operated in time coincidence with Liquid Argon neutrino detectors, achieving a major step towards the realization of the concept of tagging individual neutrinos both at production and interaction level, on an event-by-event basis.

Keywords: neutrino beam tagging positron kaon calorimeter cross section leptonic cp violation silicon photomultiplier
Innovative Modeling Approaches for Production Systems to raise validatable efficiency (IMPROVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Austria,Germany,Germany,Italy,Germany,Germany,Türkiye,Poland,Poland,Denmark
Call: ICT-enabled modelling, simulation, analytics and forecasting technologies (H2020-FoF-2015, 2015)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 4148554.0
EU funding (EUR): 4148554.0
Participants: 14
Project status: CLOSED

The rise of the system complexity, the rapid changing of consumers demand require the European industry to produce more customized products with a better use of resources. The main objective of IMPROVE is to create a virtual Factory of the Future, which provides services for user support, especially on optimization and monitoring. By monitoring anomalous behaviour will be detected before it leads to a breakdown. Thereby, anomalous behaviour is detected automatically by comparing sensor observation with an automatically generated model, learned out of observations. Learned models will be complemented with expert knowledge because models cannot learn completely. This will ensure and establish a cheap and accurate model creation instead of manual modelling. Optimization will be performed and results will be verified through simulations. Therefore, the operator has a broad decision basis as well as a suggestion of a DSS (Decision Support System), which will improve the manufacturing system. Operator interaction will be done by a new developed HMI (Human Machine Interface) providing the huge amount of data in a reliable manner. To reach this aim, every step of the research process is covered by a minimum of two experienced consortium partners, who conclude the results of the project using four demonstrators. The basis for IMPROVE are industrial use-cases, which are transferable to various industrial sectors. Main challenges are reducing ramp-up phases, optimizing production plants to increase the cost-efficiency, reducing time to production with condition monitoring techniques and optimise supply chains including holistic data. Consequently, the resource consumption, especially the energy consumption in manufacturing activities, can be reduced. The optimized plants and supply chains enhance the productivity of the manufacturing during different phases of production. Furthermore, the industrial competitiveness and sustainability in EU will be strengthened.

Keywords: data driven modelling,machine learning,simulation,predictive analytics,condition monitoring,diagnosis and prognosis,expert knowledge,cost reduction,increasing productivity
Experimental and theoretical aSsessmenT of laminaR flow rObusteness at high mach and reynolds numbers (ESTRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Italy,Italy,Netherlands
Call: Laminar Flow robustness and Load control effectiveness evaluation for a Regional Turboprop wing (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2022-12-31
Duration (months): 45.0
Total project cost (EUR): 1476050.0
EU funding (EUR): 1476050.0
Participants: 4
Project status: CLOSED

According to the requirements of the topic JTI-CS2-2018-CFP08-REG-03-01, the proposal ESTRO will produce experimental and numerical data in flow speed and in “cruise conditions” to validate the relevant aerodynamic performance of the Regional 90 sit turboprop A/C wing including laminar flow extension measurements and wing span load distribution. In particular, the tests in wind tunnel conditions will be performed at some Reynolds numbers, whose higher value is expected to be around 7-8 millions, and at low and medium Mach numbers. Accurate pressure distributions, infrared flow images, wing deformation, wall balance and load control and alleviation measurements are expected. The data will be the result of an experimental test campaign performed in a Laminar Wind tunnel with the main objective to evaluate the laminar flow robustness, the aerodynamic performances and load control effectiveness of a turboprop A/C wing at medium/low speeds (Mach numbers up to 0.38) and wind tunnel Reynolds number around 7-8 million. Numerical simulations aim to first assess the wind tunnel experimental results and then to extrapolate the data to flight conditions. In addition, the effects of the propeller on the wing laminar flow extension will be evaluated through 3D boundary layer computations coupled to linear stability analyses based on ray theory.

Keywords: laminar flow,regional,wind tunnel
Roadmaps for Energy (R4E)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Spain,Spain,Estonia,Italy,Italy,Türkiye,Netherlands,United Kingdom
Call: Enhancing the capacity of public authorities to plan and implement sustainable energy policies and measures (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 1999840.25
EU funding (EUR): 1999840.0
Participants: 10
Project status: CLOSED

Within the Roadmaps for Energy (R4E) project the partners will work together to develop a new type of energy strategy through visions and roadmaps for the 8 partner cities, in co-creation with local stakeholders. The stakeholders include the benefactors of the strategy, such as citizens, as well as relevant research and industry partners, to offer a clear picture of the future potential of the city. In the R4E project a four step process is applied. The FIRST step sets the ambitions for the project. The ambitions of the participating cities on sustainable energy and Smart Cities in general are set, as well as the partner cities' choice for 2 focus areas within Smart Energy Savings: 1.Smart Buildings, 2. Smart Mobility or 3. Smart Urban Spaces. The SECOND step is to develop desired scenarios for the cities for the selected focus areas. During the THIRD step the roadmap will be created, existing and future technologies and other developments will be identified, which enable the realization of the desired future scenarios. Opportunities and developments will be plotted on a timeline to provide insight in the required steps and milestones towards the favoured scenarios. The roadmaps will contain generic parts that are common for the partner cities, as well as specific parts that cater for the specific context of the cities. During the final and FOURTH step a project portfolio will be generated with new projects and initiatives to reach the ambitions, visions and roadmaps of the cities. This portfolio provides an overview of individual and joint projects and includes a cross-city learning plan and a financial plan. At the end of the project each partner city will each have 2 future scenarios, 2 roadmaps and a portfolio of individual and joint projects to implement sustainable energy policies and measures. Also the visioning and roadmapping capacities within the municipalities are developed to spur future development and implementation of innovative energy solutions.

Keywords: energy roadmapping,smart buildings,smart mobility,smart urban spaces,smart cities,future visions,energy visions,implementation of strategies and plans,financing
Systemic large scale eco-innovation to advance circular economy and mineral recovery from organic waste in Europe (SYSTEMIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Italy,Austria,Germany,Belgium,Belgium,Belgium,Finland,Belgium,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Systemic, eco-innovative approaches for the circular economy: large-scale demonstration projects (H2020-CIRC-2016TwoStage, 2016)
Start date: 2017-06-01
End date: 2021-11-30
Duration (months): 54.0
Total project cost (EUR): 9665580.65
EU funding (EUR): 7859828.75
Participants: 15
Project status: CLOSED

SYSTEMIC will reach a break-through to re-enter recovered nutrients from organic waste into the production cycle. Consequently, this will offer solutions for pressing environmental issues and to reduce the import of P as finite irreplaceable resource in mines. The SYSTEMIC project aims to shift the European Biomass treatment practice to the next level. Departing from existing business cases and a new ground-breaking large scale demonstration plant, the future of anaerobic digestion (AD) value chains will be investigated and demonstrated. The result will help existing and future AD-operators to maximise their performance: produce and sell more quality products, generate more energy and be independent on subsidies. By the market driven leadership, the SYSTEMIC-project will finally turn biomass waste into valuable products while reducing water pollution, greenhouse gas emission and creating quality jobs in rural areas. The planned demonstration plant will allow innovative combinations of modules to elaborate possible optimizations for increasing the production quantity and quality of new mineral products, and the integration of these products into a circular economy. Reflecting the experiences from the demonstration plant with a set of 4 mirror cases in different members states allow systemic innovation including end-user driven (a) specific technical development and (b) the cost efficient investigation of real world circular economy business cases and (c) operational, regulatory, institutional and contextual barriers to overcome. Using partial funding from the EC, the SYSTEMIC industry-driven consortium will validate for the first time the technical and economic viability of a fully integrated, multistep approach in an operational environment. The successful practical demonstration will put the European sector in a leading position to offer efficient mineral recovery technologies.

Keywords: waste valorisation,nutrient recovery,demonstration plant,biobased industries,biochemicals,biogas,secondary raw materials
Boosting Agricultural Insurance based on Earth Observation data (BEACON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Germany,Serbia,Serbia,Greece,Greece,Greece
Call: Copernicus market uptake (H2020-SPACE-2018, 2018)
Start date: 2019-01-01
End date: 2022-01-31
Duration (months): 37.0
Total project cost (EUR): 2351700.9
EU funding (EUR): 1733415.63
Participants: 8
Project status: CLOSED

To objective of the BEACON project is to develop a commercial service package that will enable insurance companies to exploit the untapped market potential of Agricultural Insurance, taking advantage of innovations in Earth Observation, weather intelligence and ICT / blockchain technology. BEACON will enable insurance companies to alleviate the effect of weather uncertainty when estimating risk for Agricultural Insurance products, reduce the number of on-site visits for claim verification, reduce operational and administrative costs for monitoring of insured indexes and contract handling, and design more accurate and personalized contracts. Through an early warning service they will be able to inform their customers (farmers) for potential crop risks related with weather conditions, and advise them to take all the necessary actions to mitigate the impact of weather in their crops. EO data derived by Copernicus Sentinel missions as well as by missions contributing to Copernicus will be used to develop the data products that will act as a complementary source to the information used by insurance companies to design their products and assess natural disasters. Weather intelligence based on data assimilation, numerical weather prediction and ensemble seasonal forecasting will be used to verify the occurrence of a catastrophic weather event and to predict future perils. ICT / blockchain technology will be used for the smart contract service, to provide insurance companies with an automated method for paying out damages to insured parties. The BEACON services will be deployed in the operational environment of more than 10 companies in the insurance sector, openly demonstrating and validating its value proposition and acceptance as a marketable commercial solution. A business model will be developed and validated using the Lean Start-up methodology, and a global roll-out of BEACON will be designed.

Keywords: agricultural insurance,meteorological data,risk management,smart contracts