Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Vapour phase deposition of metal-organic frameworks with luminescent guests for solid-state lighting and sensing (VAPOMOF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Metal-organic frameworks (MOFs) are crystalline solids with highly regular pores in the nanometre range. Because of their unique properties, MOFs are high-potential candidates for integration with microelectronics. However, current methods for MOF film deposition, a key enabling step in device integration, are incompatible with microelectronics fabrication because of contamination and corrosion issues. The VAPOMOF host group very recently demonstrated the deposition of MOFs via chemical vapour deposition (CVD). This MOF-CVD technique circumvents the above issues and opens up a plethora of opportunities for MOF integration because of compatibility with existing microelectronics fabrication infrastructure. VAPOMOF targets the expansion of the MOF-CVD platform is and its implementation in two application areas: (1) MOF-CVD coatings with encapsulated luminescent guests to enable more efficient and affordable white-light emitting diodes. (2) MOF-CVD coatings with encapsulated responsive luminescent guests for the detection of volatile organic compounds via a change in the emission properties. The combined expertise of the fellow and host ensures the best chance for successfully completing the VAPOMOF objectives in a mutually beneficial manner. In addition, a secondment at a world-leading research centre with close ties to the microelectronics industry will provide insights in industrial needs and standards and a view on valorisation of scientific research.

Keywords: metal organic frameworks,vapour phase deposition,sensors,solid state lighting,host guest chemistry
Population Dynamics of Polyploids: Testing the Mechanisms of Grassland Expansions in Madagascar (MADGRASS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-10
End date: 2024-01-09
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

As a consequence of anthropogenic climate change, it has been hypothesized that human-mediated deforestation degraded closed-canopy forest into grasslands dominated by fire- and grazing-resistant grasses. There is accumulating evidence, however, that tropical grasslands are natural biomes with origins that predate human activities. The extent to which grasslands have expanded and contracted in response to natural climate cycles versus more recent agricultural practices remains an open question and is the motivation for the proposed research. MADGRASS focuses on the grasslands of central Madagascar, because identifying ancient grasslands and protecting them is of urgent conservation interest. Population genomic methods and novel bioinformatic approaches will be used to test demographic hypotheses that will identify the timing of grassland expansions and contractions, population structure, and gene flow between populations. Research goals are made possible by recent advances in the analysis of polyploid species, which will be implemented through MADGRASS. There are direct conservation policy outcomes expected from MADGRASS. Currently, tree-planting programs are attempting to re-forest the grasslands of central Madagascar. These programs often include invasive tree species that grow quickly and require more water than is available, which can unintentionally lead to increased frequency and intensity of fires and overall detrimental outcomes. We will identify the range of Madagascar’s natural grasslands that should be protected. Results will also be used to identify which grasslands should be released from protected status for community and commercial use, building respect and trust with local Malagasy people. All aspects of the proposed research will be conducted in close collaboration with Malagasy colleagues and include specific outreach activities for both local communities in Madagascar and broader scientific and lay groups.

Keywords: grasslands,polyploidy,population genomics,historical demography,coalescent theory
Face Off. Understanding Ancient Masks (Face Off)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

“Face Off” is designed as an interdisciplinary project, whose main goal is the first comprehensive investigation and comparison of masking phenomena in the Iron Age Mediterranean (c. 12th-2nd centuries BC), aiming to explain why humans need masks and understand the connection between masks and ancient societies. Apart from focusing on the examination of the Aegean, Cypriot and Phoenician/Punic corpora of masks, this project will use scientific methods (i.e. 3D modelling, pXRF, Face Expression Recognition; Machine Learning) to investigate the transmission of mask models and the impact of ancient masks on the spectators, and to understand the age and gender of the characters represented in these faces, of the persons wearing the masks and of those attending the masked activities. A project on this chronological and geographical coverage and based on such multidisciplinary methodology is unprecedented. Investigating this complexity will provide insights into the role that masks played in some Iron Age communities across the Mediterranean basin. This project is designed to take place at Universitat Pompeu Fabra, which has the expertise, facilities and resources necessary to support such research. By viewing the ancient masks of the Iron Age Mediterranean through the lens of various disciplines and scientific methods, the proposed project entails a significant component of an exchange of knowledge, together with training through research. With its dissemination (seminar, publications) and public engagement activities (articles, lectures, exhibition), this project constitutes an innovative way of doing archaeology and intends to bring together different traditions within the European schools of Mediterranean archaeology.

Keywords: ancient masks,iron age mediterranean,religion,performances,gender,emotion,spectators,rites of passage,ancestors,superhuman beings,face recognition,machine learning
Functional contribution of visual features to hippocampal memory encoding (FindMEMO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

One of the most intriguing complex functions of the brain is its ability to transform sensory information into distinct neural representations that can be used for perception and action. Sensory inputs mediated by visual, auditory, tactile and olfactory streams drive experience-dependent learning. In particular, to form memories of the perceived outside world, characteristic visual features of the environment need to be processed by the hippocampus, a brain region that is critical for episodic memory storage in mammals. However, it is still unclear how visual properties of different environments can drive the formation of separate memories. It has been suggested that the hippocampal dentate gyrus is required to produce distinct memories in a process termed pattern separation. In particular, newly generated granule cells, which are continuously incorporated into the existing adult neuronal network, appear to be essential for this process. To understand how visual features of similar stimuli are processed in the hippocampus to drive the formation and storage of distinct memories, I will combine novel optical methods to record the activity of newly generated and mature granule cells from the hippocampal dentate gyrus with simultaneous local field potential recordings from primary visual cortex. These experiments will be performed on head-fixed mice running in a linear virtual-reality environment while discriminating a visually-driven behavioural task, and will allow me to answer the following questions: i) How do distinct visual cues drive the formation of separate hippocampal representations? ii) In turn, how is hippocampus-dependent memory formation involved in visual experience-dependent learning? My results will provide fundamental insights into the cellular mechanisms of memory formation and will address a core question in neuroscience, how different brain regions interact to create the mental representation of the outside world.

Keywords: hippocampal adult neurogenesis,sensory integration,memory consolidation
Epileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies (EpiEpiNet)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Sweden,Netherlands,Portugal
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-11-01
End date: 2024-06-30
Duration (months): 44.0
Total project cost (EUR): 900000.0
EU funding (EUR): 900000.0
Participants: 4
Project status: SIGNED

Epileptogenesis and Epilepsy Network: from genes, synapses and circuitries to pave the way for novel drugs and strategies (EpiEpiNet) aims to promote collaborative multidisciplinary and translational research in epilepsy by enhancing effective knowledge transfer, exchange of best research practices, and the mobility of early stage researchers between the Instituto de Medicina Molecular João Lobo Antunes (IMM), and leading partners at the Academic Medical Centre at the University of Amsterdam, University of Rome La Sapienza and the Epilepsy Center of LUND University. EpiEpiNet encompasses reputed neuroscientists that have in common the aim of understanding of the basic mechanisms of epileptogenesis and their impact in synaptic and brain circuitry dysregulation, and to contribute to the development of innovative therapies against refractory forms of epilepsy. Specifically, we aim at 1) increase the scientific and technological innovation in epilepsy research in the whole network and at IMM in particular by interchange of ideas and researchers among the partners; 2) sustain the network activity beyond EpiEpiNet deadline by promoting joint grant applications and joint training of PhD students; 3) train of young researchers and promote their internationalisation; 4) increase the awareness of epilepsy among the caregivers and patients, by promoting joint discussions and targeted dissemination of EpiEpiNet activities and results. As tools, EpiEpiNet will promote 1) scientific meetings, 2) community-oriented debates, 3) thematic and hands-on workshops and summer schools, 4) short term and on-site training visits in and out IMM for scientific and technology transfer between partners. The added value of EpiEpiNet will easily be spread to the University of Lisbon and to the Portuguese community, due to the existing interactions with the Mind-Brain College of the University of Lisbon, with the national neuroscientific community, and with patient and caregiver organizations.

Keywords: epilepsy,epileptogenesis,neurodevelopmental epilepsy,synaptic basis of epilepsy,molecular,mechanisms of epileptogenesis,genetic basis of epilepsy,refractory epilepsy,neuroinflammation
Pathophysiology of platelet-derived Interleukin 1 (Plat-IL-1)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1488853.75
EU funding (EUR): 1488853.75
Participants: 1
Project status: CLOSED

The Interleukin (IL)-1 family of pro-inflammatory cytokines are among the most potent pyrogens, and their excessive production can cause several auto-inflammatory syndromes. Additionally, overabundance of IL-1 cytokines can trigger, or contribute to a range of inflammatory and metabolic disorders. The expression of the key members of the IL-1 family, such as IL-1β and IL-18, is regulated at both the transcriptional and post-transcriptional levels. IL-1β and IL-18, are produced as inactive precursors, which require activation of caspase-1 by the inflammasomes for their maturation and release by from cells, occasionally at the cost of caspase-1 mediated-cell death. We have recently discovered that inflammasomes are released into the extracellular space where they remain active after the demise of activated cells, and that extracellular inflammasomes can amplify inflammation by sustaining extracellular production of IL-1β. However, the sources of extracellular pro-IL-1β are not known. Recent advances in platelet proteomics have revealed that these non-nucleated cells are able to produce their own cytokines, including soluble IL-1β and membrane-bound IL-1α, and are able to significantly magnify IL-1 production by immune cells. As platelets outnumber leukocytes by several folds, they could potentially be the major source of extracellular inflammasomes in the body, or be a major producer of IL-1 precursors that are cleaved by extracellular inflammasomes released from dying immune cells. In this proposal, we will investigate the mechanism(s) by which platelets produce IL-1, and the specific contribution of platelet-derived IL-1 to sterile inflammation, or host resistance to bacterial and viral infection. We believe that a deeper understanding of platelet-IL-1 and their interaction with immune cells during sterile inflammation, or infection might help to uncover new targets for immune-therapies.

Keywords: inflammasomes,bacterial infection,virus infection
Jigsaw puzzles at atomic resolution: Computational design of GPCR drugs from fragments (FRAGMENT2DRUG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-11-01
End date: 2023-04-30
Duration (months): 66.0
Total project cost (EUR): 1467500.0
EU funding (EUR): 1467500.0
Participants: 1
Project status: CLOSED

Despite technological advances, industry struggles to develop new pharmaceuticals and therefore novel strategies for drug discovery are urgently needed. G protein-coupled receptors (GPCRs) play important roles in numerous physiological processes and are important drug targets for neurological diseases. My research focuses on modelling of GPCR-ligand interactions at the atomic level, with the goal to increase knowledge of receptor function and develop new methods for drug discovery. Breakthroughs in GPCR structural biology and access to sensitive screening assays provide opportunities to utilize fragment-based lead discovery (FBLD), a powerful approach for drug design. The objective of the project is to create a computational platform for FBLD, with a vision to transform the early drug discovery process for GPCRs. As structural information for these targets is limited, predictive models of receptor-fragment complexes will be crucial for the successful use of FBLD. In this project, computational structure-based methods for discovery of fragment ligands and further optimization of these to potent leads will be developed. These techniques will be applied to address two difficult problems in drug discovery. The first of these is to design ligands of peptide-binding GPCRs that have been challenging for existing methods. One of the promises of FBLD is to provide access to difficult targets, which will be explored by combining molecular docking and biophysical screening against peptide-GPCRs to identify novel lead candidates. A second challenge is that efficient treatment of neurological disorders often requires modulation of multiple targets, which also will be the focus of the project.

Keywords: fragment based drug discovery,molecular docking,virtual screening,g protein coupled receptor
Cement-based materials, properties, evolution, barrier functions (Cebama)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Germany,Germany,Spain,Germany,Switzerland,Switzerland,Romania,Switzerland,Belgium,Finland,France,France,France,France,France,Czechia,Czechia,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Japan
Call: Supporting the implementation of the first-of-the-kind geological repositories (NFRP-2014-2015, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 5952944.5
EU funding (EUR): 3868607.25
Participants: 32
Project status: CLOSED

The HORIZON 2020 EURATOM Collaborative Project “Cement-based materials, properties, evolution, barrier functions (Cebama)” is developed with the overall objective to support implementation of geological disposal of nuclear waste by improving the knowledge base for the Safety Case. Cement-based materials are highly relevant in this context, being used as waste forms, liners and structural components or sealing materials in different types of host rocks and disposal concepts. Specific objectives of Cebama are (i) experimental studies of interface processes between cement based materials and host rocks or bentonite, and assessing the specific impact on transport properties, (ii) quantifying radionuclide retention under high pH cement conditions, and (iii) developing comprehensive modeling approaches. Modeling will support interpretation of results and prediction of the long-term evolution of key transport characteristics such as porosity, permeability and diffusion parameters especially in the interface between cement based materials and the engineered and natural barriers. Further objectives cover dissemination of results to scientific and non-scientific stakeholders as well as training and education of young professionals for carrying over the expertise into future implementation programms. To a large extent, the experimental and modelling work will be part of PhD theses, aiming at high scientific-technical impact and quality with respect to peer-reviewed publications. The 4 years project is implemented by a consortium of 27 partners consisting of large Research Institutions, Universities, one TSO and one SME from 9 EURATOM Signatory States, Switzerland and Japan. National Waste Management Organizations support Cebama by co-developing the work plan, participation in the End-User Group, granting co-funding to some beneficiaries, and providing for knowledge and information transfer.

Keywords: cement,interfaces,radionuclide,barriers,modelling
The Normativity of Sacred Images in Early Modern Europe (SACRIMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2022-08-31
Duration (months): 75.0
Total project cost (EUR): 1493125.0
EU funding (EUR): 1493125.0
Participants: 1
Project status: CLOSED

What is a sacred image? This is a crucial question for multicultural Europe – today as well as in the past. Between 1450-1650 Europe underwent, at the same time, an impressive artistic development and a dramatic religious crisis during which the status of the sacred image was repeatedly contested. Focusing on a comparison between five major areas that, remaining inside Catholicism, responded differently to the challenge imposed by the Reformation, SACRIMA will investigate the relations between art, religion and geography proposing to break ground in two main ways. First, by using and developing the concept of ‘normativity’ in a double sense: institutional normativity and visual normativity. Second, by adopting a comparative approach at the crossroads of the history of art, the history of religion and cultural geography. Starting from a new systematic survey of image-based material in ecclesiastical archives, it proposes: 1) A comparative survey of contested images in the Italian peninsula and islands, France, Iberia, the Low Countries and Southern Germany. 2) An investigation of ‘visual norms’ through focus on three complementary aspects: styles (in particular, the limits of realistic effects), iconographic norms, and the role of reproduction, restoration and reframing. 3) An exploration of the geography of reactions to art transfer aiming at reconstructing a cross-border cartography of visual norms in Europe and the Mediterranean. The proposed focus on the capacity of art to impose new normative visions of sacred subjects as well as to produce reactions which are often geographically differentiated opens new perspectives on the relations between art, religion and cultural transfer, shedding new light on previously explored notions of ‘image censorship’, the ‘power of images’ or the ‘performance of images’. The overall project will contribute to the understanding of dynamics of cultural integration, differentiation and local negotiation in early modern Europe.