Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
StART: Science through ART (StART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Türkiye
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2019-03-01
End date: 2019-11-30
Duration (months): 9.0
Total project cost (EUR): 131875.0
EU funding (EUR): 131875.0
Participants: 1
Project status: CLOSED

RN2019 Turkey is organized in Ankara by the Science and Society Center of Middle East Technical University (ODTÜ) to promote public recognition of “Science through ART – StART” and thus reveal the value of thinking outside the box. Art is utilized as an overarching theme because of its familiarity, which has great potential to break conceived barriers between science and society. The setting will be around five key areas each corresponding to a branch of art, namely drawing-painting, sculpture, architecture, music-dance, photography. Around each of these areas, we will host activities where invited science and art communicators will explain the many interactions between science and art through their works. That is, it will show how art can be inspired by science and vice-versa and how art and science can collaborate to better understand the world around us and increase our welfare. Our science communicators are mainly experienced researchers, but then again scientists and artists will be brought to the same platform since they both strive to see the world in new ways and communicate that vision; and thus “are more alike than different”. We aim to reach 10,000 on-site participants and 1,000,000 on-line or indirect beneficiaries regardless of their age and background. Nonetheless, special focus will be given to students ranging from pre-schoolers to high school students. The ultimate messages conveyed via StART will be “Science and art are indispensable to the human need of understanding the world around us.”, “A research career on science and art can be fun!”, and “Researchers are everywhere!”. Celebrating artistic creations and scientific discoveries can be a truly memorable experience for our beneficiaries. For younger audiences, the event may provide a life-changing moment, when they not only recognize the importance of science and how imagination informs scientific discovery, but also get to meet and talk to researchers and be drawn closer to careers in science.

Keywords: art and science,european researchers night,science festival,science communication,public at large
Improving Gender and Immigrant Outcomes through the Social Malleability of Attitudes: Randomized Interventions on Peer Interactions in an Educational Setting (SOCIALMALLEABILITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Türkiye
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

This project studies the causal role of peer interactions and the nature of the classroom environment in the formation of individual beliefs, attitudes and non-cognitive skills in childhood, with a view towards (1) mitigating gender gaps in choices and outcomes, (2) improving attitudes towards immigrants and promoting integration, (3) improving achievement outcomes. To this end, the project will design randomized interventions on social interactions in the classroom, that exogenously manipulate (i) exposure to peers (randomizing gender and ethnicity combinations), (ii) the setting in which the interaction takes place (cooperative vs. competitive). The conjecture is that particular types of peer interaction (e.g. cooperative work) can permanently shift both individual preferences and attitudes toward others, and lead to contagion of non-cognitive skills. The interventions will be embedded into a novel extracurricular program to be designed around teaching “coding”, and” and will be implemented across a large set of elementary schools in Istanbul, for the duration of a semester. The project will utilize an interdisciplinary methodology that involves collecting a large set of outcome measures through novel incentivized experiments, questionnaires, and neural measurements. Impact of different types of peer interactions and a cooperative vs. competitive classroom culture on attitudes towards gender and immigrants, individual preferences and non-cognitive skills, creativity, aspirations and achievement will be measured both in the short- and the longer-run, in an entirely new social context. Comprehensive baseline data on individual, family and classroom characteristics will allow us to study heterogeneous effects and potential mechanisms. The results will provide inputs for how the educational environment can be designed early on, to build a culture that promotes gender equality, cultivates positive attitudes towards immigrants, and improves achievement outcomes.

Keywords: gender,preferences,non cognitive skills,education,immigrants,field experiments,laboratory experiments,neuroeconomics
Metabolic diseases from the point of view of the gut bacterial motility and mucus barrier (MEDMOTILUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

MEDMOTILUS aims to uncover the alterations of gut mucus/microbiota homeostasis in metabolic diseases and therapeutic targets using human data and animal models. It will fill research gaps in the multiple scenarios of metabolic diseases, one of the greatest threats to human health. The gut microbiota is a key environmental factor of these diseases, and its modulation is a potential treatment. However, the host-microbiota interactions are far from being fully described. The gut mucus barrier is a host spatial control that plays a crucial role in the microbiota regulation but poorly understood. Diet and medicines may affect this defense and, thus, improving metabolism and reducing gut bacterial motility, whose increase is linked to health disorders even without serious infections. However, there is no in-depth bacterial motility characterization in metabolic diseases and no data on mucus features nor on its effect on bacteria in these diseases. So, the overall research goal of MEDMOTILUS is to provide evidence of the impact of gut bacterial motility and mucus in metabolic diseases as key factors involving dysbiosis, mucus features, and metabolic status. MEDMOTILUS takes a multidisciplinary approach. It will go beyond the current state-of-the-art by using original input data (bacterial motility from modeling and mucus features) with multi-omic approaches (also metabolomics and metagenomics). Several potential solutions acting on mucus will be assessed in mice. The use of human data already generated and animal models (mice and a new pig model) will allow me to identify robust and useful biomarkers of the gut mucus/microbiota homeostasis in metabolic diseases for further research on diagnosis and monitoring to reduce long-term complications and deaths. At the level of my career, MEDMOTILUS will allow me to enhance my research profile and network, strongly impacting my chances of achieving my long-term goal to become a Professor and develop a prolific scientific career.

Keywords: animal model,bacterial motility,integrative analysis,metabolic diseases,metagenomics,microbiome,microbiota,mouse,mucus barrier,multi omics,obesity,type 2 diabetes mellitus
3D Living Tissues (3DLT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Prometheus S.r.l. develops and markets 3D human like tissues for regenerative medicine and pharmacological tests. A proprietary 3D Bioprinting Technology enables Prometheus to make use of human living cells as ink, to building up 3D tissues equal for structure and features to the human ones. The human living cells are printed by a strictly controlled process with high resolution, remaining alive during the entire printing process and for a long time beyond. The cutting edge new tissues satisfy the requests of pharma/cosmetic companies to reduce R&D expenditures and times for new products commercialization. Prometheus will go-to-market in Jan 2019 with its 1st product: Ematik, for wounds care. In this framework, Prometheus is undertaking a new business opportunity: a 3D Lymph Node (3DLN) for the testing of new immunotherapies against cancer. The 96% of oncological drugs efficient/safety in preclinical tests, fails human clinical trials, with a 2,5Bln$ expenditure/drug. This high failure rate is due to in vitro tests performed with current unreliable tissues: uncomplete, with different cell composition and compartmentalization respect to the corresponding human once. Contrary, Prometheus’ 3D Lymph Node is equal to the human one for composition, structure and functionality, providing more predictive data. Each company tests 80 new molecules/year and spends ≈4 Mln$ for in vitro tests, excluding animal testing (≈4 Mln$). Market of products for immuneonco testing is estimated in 2Bln€. According to key topics, all potential EU customers yearn to find on the market, asap, at any price, a 3D Lymph Node as the one of Prometheus, whose features allow to rapidly acquire a 4% EU market share in 5 years (40Mln€). During the feasibility study we will assess 3DLN project economic feasibility, we will connect with potential customers, estimating deeply market share, defining a revenue forecast, connecting with industrial and commercial partners, define also an IP strategy.

Keywords: bioprinting,3d printing,lymph node,human living tissue,drug test,pharmaceutical companies,immune system,immunotherapies,cancer,oncological durgs
Studying Ciliary Signaling in Development and Disease (SCilS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Italy,Spain,France,Netherlands,Denmark,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 3844874.16
EU funding (EUR): 3844874.16
Participants: 11
Project status: SIGNED

SCilS will create a multidisciplinary and intersectoral European training network focusing on ciliary signalling in development and disease. Primary cilia are microtubule-based cell surface projections that have evolved to be key signalling hubs of our cells, as they concentrate or segregate components of major cellular signalling pathways. Control of ciliary signaling output requires a high degree of regulation and critical feedback, which is needed for robustness in development and cellular homeostasis of different tissues and organs. Dysfunctional cilia can therefore lead to >35 severe human genetic traits (ciliopathies) with highly heterogeneous, overlapping phenotypes. Ciliopathies affect as many as 1 in 400 people, and for the majority of cases efficient therapeutic interventions are currently unavailable. SCilS research aims to uncover the multi-level organization and regulation of cilia-mediated signalling pathways in order to understand ciliopathy disease etiology and identify novel therapeutic targets. This challenging task will be accomplished by integrating unique expertise and cutting edge technology available within the SCilS network, including structural biology, super resolution imaging and cryo-electron tomography, state-of-the-art genomics, proteomics and bioinformatics, (stem) cell biology and biochemistry, as well as organoid technology and zebrafish models. SCilS training will give Early Stage Researchers (ESRs) unparalleled training opportunities in outstanding academic and industrial settings through training-by-research via individual research projects, secondments, and network-wide training sessions. All individual training and research activities have been designed to provide each ESR with the necessary broad competences in state‐of‐the art academic and industrial research. The network will thereby make a career in both industry and academia attractive to the ESRs and improve their career prospects in both private and public sectors.

Keywords: cilia,ciliopathies,cellular signalling,muli omics,structural biology,organoids,molecular disease mechanisms
Efficient manufacturing technology for complex architecture (Svelte)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Romania
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 2385213.0
EU funding (EUR): 1669648.75
Participants: 1
Project status: SIGNED

Finding a cost-efficient solution to create fluid, complex shapes has been the Holy Grail of architecture and engineering worldwide. Svelte uses a proprietary, unique, innovative machine system to generate all types of curved surfaces on an industrial scale, in one straightforward operation, at a fraction of the cost and time of current methods. Svelte works on a patented advanced cutting method using a heated SmartWire that changes its shape while moving through foam or wax-based materials to generate the desired surfaces. Svelte disrupts the currently used CNC milling processes similarly to how 3D printers impacted the prototyping industry, pushing the boundaries of what is possible today to change architecture as we know it. A Svelte produced mould is at least 50% cheaper than a regular milled mould and has the ability to be mass produced in minutes, making the output of a single Svelte system equivalent to approximately 48 CNC machines. Svelte will therefore enable for the first time growth in the emerging special buildings niche to achieve the spectacular, innovative, energy efficient fluid forms of the future; but also generate substantial savings in the traditional building sector. Integrating Svelte cut shapes in existing building projects preserves their structural integrity, but uses up to 30% less construction materials, adding up to significant savings in energy, water, sand, CO2, coal, methane, NOX, and PM10 particles in Europe’s most polluting industry. Having confirmed Svelte’s market acceptance and potential during the SME Instrument Phase 1 project, the focus is now on bringing the technology to TRL 9 during the proposed EIC project. In this scope we envision the optimization of the machine’s cutting function and prepare it for scaling to commence commercialization under both a FIAB model, but also as a SaaS solution producing moulds and panels in our own production facility.

Keywords: constructions,construction technology,formwork,building,free form architecture,double curved,panels,architectural panels,advanced wire cutting,curved glass,wind turbines
Cryo-EM Imaging of Histone Recycling at the Replication Fork (Cryo-H-Rec)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

DNA replication is essential for cell proliferation. In eukaryotic cells, DNA is densely packaged in nucleosome arrays that form chromatin. Such organisation protects the genetic material and controls access to DNA, thus providing an important mechanism for regulating gene expression. The eukaryotic replication machinery has evolved to unravel nucleosomes in order to access and duplicate DNA, while also maintaining chromatin density on newly duplicated DNA. To achieve this, the replisome dismantles nucleosomes ahead of the replication fork and reassembles them on nascent DNA strands, by coordinating redeposition of parental and newly synthesized histones. Histone proteins are subject to an array of post-translational modifications (PTMs), providing an epigenetic code that modulates activation and silencing of specific chromosomal regions. Redeposition of parental histones with their PTMs on both nascent DNA strands is, thus, pivotal in transmission of the epigenetic marks to daughter cells. I intend to perform in vitro reconstitution of the replisome on a chromatinised template and use cryo-electron microscopy to image DNA duplication and parental histone recycling at the replication fork. I seek to describe different structural intermediates in the process of nucleosome disassembly, DNA duplication and histone incorporation into new nucleosomes. To capture and characterise intermediate states of the replication machinery during this concerted process, I will employ a multidisciplinary approach and resort to structural techniques complementary to cryo-EM like solution NMR spectroscopy and crosslinking-mass spectrometry (XL-MS). My results will help dissect the role of different replisome components in nucleosome reshuffling at the replication fork, and elucidate the molecular mechanism that underpins chromosome replication and epigenetic inheritance.

Keywords: dna replication,replisome,nucleosome,chromatin,chromosome,epigenetics,cryo em,macromolecular machines
Perceiving the intentions of the weakest link: How attributed individual and collective goals impact reactions to low performers in groups (Goal Attribution in Groups)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 171795.6
EU funding (EUR): 171795.6
Participants: 2
Project status: CLOSED

Group work has become increasingly important for many tasks and services in organisations, and organisations thus depend on successful team function. The entire group’s performance may depend on the lowest performer (weakest link), but groups’ reactions to low performers are not well understood. We suggest that goal attributions are a neglected but potentially powerful factor: Did the low performer try to outperform others (individual goal) or contribute to the group (collective goal)? In the next step, groups should evaluate whether low performers were trying to succeed (but had insufficient abilities) or were not trying (i.e., had low goal commitment). Failing despite trying will lead to excluding competitive low performers (individual goal) but lead to training cooperative low performers (collective goal). Vice-versa, lack of commitment to the collective goal to cooperate should lead to exclusion, but in attempts to change the individual goal of a competitive low performer (socialisation). These hypotheses will be tested in a series of four experiments to attain the objectives of complementing Dr. Thürmer’s skillset in (1) small group theory, (2) small group laboratory experiments, (3) transformative multilevel statistics, and (4) to advance the translational transfer to organizational settings. Publications in leading peer-reviewed scientific journals will disseminate the research results widely. The proposed action will open up the immediate career opportunity to establish his independent research group, will substantially advance his research program, and is a crucial step towards becoming a full professor in Germany. Acquired start-up funding enables extensive pre-testing and will ensure the success of this action. This trans-disciplinary research project will contribute to motivation science, small group research, and organizational science and the findings will help European organisations that rely on group work to improve team functioning.

Keywords: self regulation,goals,motivation,small groups,teams,performance,deviance
Mathematical Frontiers in the Analysis of Many-particle Systems (MAFRAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1950637.0
EU funding (EUR): 1950637.0
Participants: 1
Project status: SIGNED

The recent growing mathematical activity around the partial differential equations of kinetic theory has lead to deeper and deeper conceptual breakthroughs. This has opened new paths, and has created new frontiers with other cutting-edge fields of research. These frontiers correspond to three combined levels: the dialogue with another world-leading research community; the uncovering of deep new connexions and methods through this interplay; the possibilities of making significant progresses on a fundamental open problem: I. with the elliptic regularity community (regularisation for nonlocal collision operators, De Giorgi- Nash theory): the main challenge is the well-posedness of the Landau-Coulomb equation; II. with the dispersive and fluid mechanics equations communities (nonlinear stability driven by phase mixing): the main challenge is the damping stability of non spatially homogeneous structures; III. with the dynamical system and probability communities (mean-field and Boltzmann-Grad limits): the main challenge is the rigorous derivation of the fundamental equations of statistical mechanics on macroscopic times; IV. with the applications to biology, ecology and statistical physics (emerging collective phenomena for open many-particle systems): the main challenge is the understanding of steady or propagation front solutions and their stability outside the realm of the 2d principle of thermodynamics. These frontiers can rapidly lead to key advances with potential impact in mathematical analysis and fundamental physics (plasma physics, statistical mechanics); the work program Horizon 2020 would strongly benefit from the construction of a world-class research centre devoted to them. This is my objective in this project: I have played a key role in the opening of these frontiers, I propose new approaches, I have experience in building a research group, and the University of Cambridge, where I am based, would provide a unique supportive environment.

Keywords: many particle systems,application to kinetic theory,application to plasma physics,application to fluid mechanics,theoretical statistical physics,application to ecological models of population