Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Services to Boost Energy Renovation in Hungarian Homes (RenoHUb)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Hungary,Hungary
Call: Integrated home renovation services (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-11-15
End date: 2023-05-14
Duration (months): 42.0
Total project cost (EUR): 1558298.75
EU funding (EUR): 1558298.75
Participants: 5
Project status: SIGNED

RenoHUb aims to trigger a significant upscale of the energy retrofits of the Hungarian homes through the development of an integrated business model that is sustainable and cost-covering after the end of the project. RenoHUb intends to enable households to take the first step towards becoming prosumers, and map and remove all the non-financial barriers which cause setbacks in the process. The project addresses the entire value chain of home retrofit: from social, behavioral, communication and capacity building aspects through supporting the decision-making and the technical implementation, up to ex-post assessment of energy and cost saving. The key project focus includes the promotion of trilateral cooperation between the home owners, the existing local “Sparkasse” (building saving society) institutions as well as commercial and development banks. The total of 4.4 million of Hungarian households accounts for some 33-35 percent of the country's energy consumption. Two-thirds of residential building stock is energetically outdated. Hungary’s final energy saving commitment by the end of 2020 assumes 167,5 PJ. With the current pace of the energy refurbishment in the residential sector, this target is unlikely to be achieved. The goals for 2030 have already been drafted in the National Energy and Climate Plan (NECP) and will be decided by the end of 2019. The residential sector will be the primary sector targeted for energy efficiency developments since after demonstrating a slight decline within the period of 2005-2015 the overall energy consumption of the residential sector has increased since 2015. RenoHUb encompasses extensive consultations with stakeholders, including financing institutions, as well as capacity building, pilot renovation activities and targeted communication. The key project outcome will be a Renovation Hub model that is based on a “one-stop-shop” scheme. It will integrate an on-line platform and physical advisory hotspots in order to increase the renovation rate both in the multi and single family building segments in Hungary.

Keywords: one stop shop,energy renovation,integrated business model
INNOVativing the uptake of Energy Auditing Schemes for SMEs (INNOVEAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Germany,Spain,Italy,Germany,Italy,Italy,Slovenia,Belgium,Poland
Call: Capacity building programmes to support implementation of energy audits (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-06-01
End date: 2022-05-31
Duration (months): 36.0
Total project cost (EUR): 1999875.0
EU funding (EUR): 1999875.0
Participants: 10
Project status: CLOSED

The INNOVEAS project is an initiative promoted by 10 partners, from 6 EU countries, to build and deliver a capacity building programme, aiming at addressing the major non-technical barriers that most often hamper the adoption the energy auditing practice, in particular among those actors, such as SMEs where such audits are not required by law. The ultimate goal is to consolidate a structured, permanent and expandable offer to help develop continuous self-sustainable services to raise awareness and build capacity in the field of energy auditing and related energy saving measures in SMEs. The project therefore aims at designing and deploying staff trainings and capacity building programmes to enhance corporate policy towards energy efficiency, energy culture (motivations, behaviour change, mitigation of perceived risks and barriers) and sustainable supply-chain initiatives. It therefore intends to: i) Advanced analysis of behavioural barriers to energy audits, to identify and analyse the enabling conditions and non-technical barriers hindering the adoption of energy auditing practice; ii) Delivery of self-sustainable capacity building programmes, in order to systematise awareness raising procedures to overcome the psychological and organisational barriers to energy audits in SMEs, deliver a training offer to SMEs and formulate a capacity building programme targeting stakeholders such as intermediaries, policy makers and financing institutes; iii) Create an institutional structure to sustain the project’s objectives and results and lay the basis for the creation and consolidation of a pan-European network of enablers likely to support in the coming years the growth and expansion of the training offer to on energy efficiency for European business.

Keywords: behavioural change,energy culture,energy audit,smes
LymphoDrain: The definitive solution for chronic lymphedema (LymphoDrain)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2023-01-31
Duration (months): 41.0
Total project cost (EUR): 2586750.0
EU funding (EUR): 1810725.0
Participants: 1
Project status: CLOSED

Lymphedema (LE) is a chronic disfunction of the lymphatic system causing fluid accumulation in the limbs, which affects more than 100 million patients worldwide. Its occurrence is closely related to cancer, being a very common side effect of cancer therapies, but can also arise from genetic disorders or due to injury, trauma, venous disorders, obesity, immobility, etc. Despite recent advances, at present there is no cure for LE which becomes a chronic disorder. The disease must be treated constantly by the patient, to avoid complications, with daily use of compression garments, physiotherapy and skin care. Thus, it creates a constant disability for the patient and, more importantly, it affects his/her ability to work and to live a normal life. In Europe, the financial impact of LE is valued at around €832 million in health and social welfare bills, with an additional €2.3 billion used to treat infections secondary to LE, as well as an additional €4.4 billion in loss of earnings as a result of productive incapacity of the patients. In addition, the prevalence of chronic LE is expected to grow as the life expectancy increases and the global population ages. There is an urgent need for innovative approaches to restore continuous lymph flow drainage in affected tissues, producing a definitive solution for LE. Lymphatica´s subcutaneous implant, LymphoDrain, consists of a draining catheter and a micro-pump externally controlled by a wearable device, and replaces the function of lymphatic vessels. It is implanted via a minimally invasive procedure, and results in the resolution of the physiological impairments caused by LE reducing pain, the risk of potential complications and the need for additional treatments. Lymphatica´s goal is to convert LymphoDrain in the first definitive solution for LE patients and a clear solution for reducing the impact of LE on both the healthcare system and the economy of each country.

Keywords: subcutaneous implantable medical device,lymphedema,lymph,drainage system,clinical,validation,ce marking
High quality cellulose recovery from AHP: From used diaper to coatings additive (Cellulose recovery)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Netherlands
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Every year 7.5Mton of Absorbent Hygiene Product (AHP) waste is produced in Europe. This is disposed either by landfilling or incineration. AHP waste consists of disposable child nappies, adult incontinence products, feminine hygiene and similar products. Thereof, 30% corresponding to 2.25 Mton/year can be collected as mono-stream AHP waste. However, current state of the art does not offer an economically viable solution for the recovery of raw materials from this stream. The underlying reason is that existing technology strongly depends on waste disposal gate fees and produces cellulose with a purity of typically 70-75%, which is only suitable for low grade application, e.g.as cardboard. The main objective of the innovation project is to provide a technical solution for the recycling of high grade cellulose from AHP waste. The patented process is based on dissolving lignin with mild acids, thus upgrading the overall cellulose purity. Based on this solution a total of 360 kton of cellulose per year with a high degree of purity (> 92%) can be produced from the AHP waste. This high quality cellulose that can be used as paint additive or as chemical building block, could result in an economically viable operation without depending on gate fees. The proposed valorisation of Psicon’s process represents a potential total value increase for the European economy of up to 360 M€/year and 2,000 new jobs. The European environment strongly benefits as CO2 emission is reduced up to 700 kton/year and reducing resources consumption by reusing them. The long term ambition of Psicon is to create enough production sites, at strategic locations close to the feedstock, in order to be able to convert 70-80% of the mono-stream AHP waste. This is a significant step towards near-zero AHP waste in Europe. In this feasibility assessment the final hurdles will be taken towards an EU wide market introduction supported by demonstrating the process of Psicon in an operational environment.

Keywords: cellulose,ahp products,raw materials,incontinence products,waste conversion,circular economy
Readiness of ICOS for Necessities of integrated Global Observations (RINGO)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Germany,Germany,Spain,Estonia,Ireland,Italy,South Africa,Germany,Germany,Germany,Germany,Italy,Italy,Switzerland,Switzerland,Norway,Belgium,Finland,Poland,Sweden,Sweden,Sweden,Hungary,Belgium,Belgium,Greece,Romania,France,France,Czechia,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2016-1, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 4719680.0
EU funding (EUR): 4719680.0
Participants: 51
Project status: CLOSED

The proposed project “Readiness of ICOS for Necessities of integrated Global Observations” (RINGO) aims to further development of ICOS RI and ICOS ERIC and foster its sustainability. The challenges are to further develop the readiness of ICOS RI along five principal objectives: 1. Scientific readiness. To support the further consolidation of the observational networks and enhance their quality. This objective is mainly science-guided and will increase the readiness of ICOS RI to be the European pillar in a global observation system on greenhouse gases. 2. Geographical readiness. To enhance ICOS membership and sustainability by supporting interested countries to build a national consortium, to promote ICOS towards the national stakeholders, to receive consultancy e.g. on possibilities to use EU structural fund to build the infrastructure for ICOS observations and also to receive training to improve the readiness of the scientists to work inside ICOS. 3. Technological readiness. To further develop and standardize technologies for greenhouse gas observations necessary to foster new knowledge demands and to account for and contribute to technological advances. 4. Data readiness. To improve data streams towards different user groups, adapting to the developing and dynamic (web) standards. 5. Political and administrative readiness. To deepen the global cooperation of observational infrastructures and with that the common societal impact. Impact is expected on the further development and sustainability of ICOS via scientific, technical and managerial progress and by deepening the integration into global observation and data integration systems.

Keywords: esfri,eric,climate change
Promoting building retrofits in the private residential sector through One-Stop-Shops in Germany (ProRetro)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Germany,Germany,Austria,Germany,Germany,Sweden,France,France,Netherlands
Call: Integrated home renovation services (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 1797470.0
EU funding (EUR): 1797470.0
Participants: 13
Project status: SIGNED

The ProRetro project aims to - Overcome barriers to residential building refurbishment by offering new one-stop-shop services to customers in five German cities/regions - base the one-stop-shop design on the needs of customers so that - they are attractive to customers, - conceptualise, plan, implement and monitor and evaluate the new one-stop-shops - prepare their continuation beyond the project lifetime - cover the whole customer journey of a building renovation from audit/advice, planning, contracting, implementation and monitoring and approval – and involve respective stakeholders/experts in the service offer - build on information and experiences in designing and implementing one-stop shops from best practice examples in other European countries and establish peer-learning structures with those organisations

Keywords: one stop shop,energy advice,peer learning
Engineering disease resistance gene networks: synthetic helpers for expanded sensors (BoostR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

To resist pathogen colonisation, plants have evolved a number of complex defense mechanisms that are activated upon recognition of pathogen-secreted molecules. These include cell surface or intracellular immune receptors, through either direct or indirect binding. Nucleotide-binding leucine rich repeat proteins (NB-LRRs or NLR) make up the largest family of intracellular immune receptors. Some of these NLR proteins were shown to function in pairs, with “sensors” mediating pathogen recognition and “helpers” eliciting a resistance response. Preliminary data revealed that many Solanaceae NLR sensors are dependent on three NRC (NLR proteins required for HR associated cell death) helper proteins (NRC2, NRC3, NRC4) in a complex and redundant signalling network. These NLR sensors, and their homologs, confer resistance to a diverse number of Solanaceae pathogens, including bacteria, oomycete, viruses, nematodes and insects. This suggests that NLR helper proteins play a major role in mediating disease resistance against a range of plant pathogens that infect the Solanaceae family. My objective is to use this information to engineer synthetic NRC helper proteins with enhanced sensor specificities. This will potentially result in resistance effective against multiple pathogen species currently affecting Solanaceae crops. To achieve my objective, I will undertake functional analyses of helper-sensor pairs, and study their interaction with known pathogen effectors to generate both chimeric and mutant NRC proteins with novel properties. I will then assess these candidate NRC proteins for enhanced disease resistance using a variety of genetic complementation assays. At the completion of this project I will deliver synthetic NRC helper proteins that confer expanded disease resistance in Solanaceae crops.

Keywords: nlr proteins,resistance genes,effector triggered immunity,defence genes,sustainable crops,durable resistance,immune receptors
Unlocking the potential of cryo-electron tomography by simplification of the sample preparation workflow (Cryo-SECOM Workflow)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2023-05-31
Duration (months): 45.0
Total project cost (EUR): 3062500.0
EU funding (EUR): 2143750.0
Participants: 1
Project status: SIGNED

The interest for cryo electron microscopy (cryo-EM) has risen tremendously since the Nobel Prize in Chemistry 2017 was given for Cryo-EM. The next step in Cryo EM, Cryo Electron Tomography (cryo-ET), makes it possible to resolve tertiary and quaternary protein structure interactions in relevant biological samples such as cells and bacteria. However, in the current cryo-ET workflow the sample preparation is the bottleneck. Today, sample preparation is a manual process of 4-8 hours, involves 22 steps and is performed by a PhD level operator. Even so, >80% of the samples end up unusable, due to the extreme complexity of making samples. Sample preparation is therefore also incredibly costly, as imaging time on expensive Cryo-TEMs is wasted on trying to image unusable samples. In order to make cryo-ET fulfil its potential, the sample preparation has to become fast, cheap and reliable. DELMIC has completely reimagined the cryo-ET workflow, with the ultimate vision of completely automating sample preparation. Central to this workflow is the cryo-SECOM, which integrates a correlated cryo light microscope with a FIB/SEM system. Additionally, a unified carrier simplifies the placing and carrying samples around and the sample handling and loading/unloading procedures are automatized. We will tie all workstations together, basically creating a ‘cryo-ET sample prep robot’. This fully integrated workflow approach reduces the switching between many workstations, gives higher yield, and offers unprecedented precision in targeting the area of interest. By simplifying the workflow and reducing the preparation time, the Cryo-SECOM Workflow will allow researchers to innovate faster, decreasing the sample preparation time by 87% and improving the yield by 8-fold. The cost per sample will be greatly reduced by 90%. The Cryo-SECOM Workflow will be key in unlocking the full potential cryo-ET, opening new horizons in structural biology research. "

Keywords: cryo electron microscopy,tomography,nanoscience,visual proteomics
Bile acids and epithelial stem cells in intestinal development (BESIDE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

This project will investigate how gut bacteria (the microbiota) influence development of the human gastrointestinal tract (GIT) through innovative research at a world leading research centre (the APC Microbiome Institute) and secondment to the R&D division of a leading multinational biotech company (Perkin Elmer). The gut microbiota comprises a complex community of microorganisms that provide essential metabolic functions in the host. The colonisation of the gut begins during the antenatal period, continues after the moment of birth and is coincident with rapid morphological and functional gut maturation suggesting that these early colonisers and their metabolites have an impact on GIT barrier development. Bile salt hydrolase (BSH) activity (which deconjugates amino-conjugated bile acids in the gut), is present among the first colonisers of the GIT. Thus, the BESIDE project hypothesis is that this bacterial BSH activity critically affects GIT development and maturation in early life. To understand the mechanisms underlying this relationship, BESIDE will conduct a series of experiments to i) determine how BSH activity influences intestinal stem cells (IESCs); ii) identify the effects on proliferation of these IESCs and iii) extrapolate the obtained results using an in vivo model. BESIDE presents a novel approach using methods based on cutting-edge cell culture, flow cytometry and cell imaging to gain knowledge which is likely to inform the future development of therapeutics to improve barrier function in the neonate. Additional objectives of BESIDE include dissemination and transfer of knowledge to relevant stakeholders (as well as to the general public) and the development of management and career development skills. This, in line with the Work Programme for the MSCA fellowship, will help the applicant to become an independent professional scientist in the field so that she will continue to make significant contributions to the European society and economy.

Keywords: bile salt hydrolase activity,bile acids,microbe host interaction,postnatal gut development,gastrointestinal microbiome