Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transgenic dissection of the neural circuitry of memory and dementia (MECEDGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-11-29
Duration (months): 24.0
Total project cost (EUR): 196400.4
EU funding (EUR): 196400.4
Participants: 1
Project status: CLOSED

Our memories are arguably what make us who we are, making dementia a particularly cruel disease. Decades of research have revealed that two interconnected brain regions, the medial entorhinal cortex (MEC) and hippocampus (HP), are required for successful spatial memory formation in mammals. Each region contains specialized neurons that fire relative to the animal`s position in physical space: grid cells in the MEC have regularly-repeating spatial firing fields throughout the entire environment (“grid field”); and place cells in the CA1 region of the HP fire at a particular location within an environment (“place field”). Spatial information from the MEC grid cells reaches CA1 place cells in two ways: through an (1) indirect pathway (IP) via layer II MEC neurons, or a (2) direct pathway (DP) via the layer III MEC neurons. Thus, hippocampal neurons compare processed and unprocessed input. However, the relative roles of these two kinds of input onto hippocampal firing patterns remains elusive, largely due to the difficulty in performing layer-specific manipulations. The Kentros lab at NTNU has developed a novel and exciting genetic technology that makes such experiments possible. Therefore, I propose to conduct in vivo electrophysiological recordings in CA1 while manipulating the DP to determine the effects of direct MEC input on hippocampal network dynamics. I will then investigate the behavioral ramifications of manipulating the DP on spatial task performance. Interestingly, the superficial layers of entorhinal cortex are the first brain area to exhibit the pathological signs of Alzheimer`s Disease (AD) in patients. Therefore, I will compare the relative roles of entorhinal layer II and III neuron activity in the progression of pathology in a preclinical mouse model of AD. Thus, this proposal will provide insight into how the distinct circuit elements of the entorhinal cortex contribute to place field formation, memory performance, and disease progression.

Keywords: place cells,hippocampus,medial entorhinal cortex,chemogenetics,enhancers,transgenics,alzheimer s disease
Colonial Consequences of the Japanese Empire in the Mariana Islands (ColonialConsequences)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-15
End date: 2023-11-12
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Understanding colonial cultural impacts on Indigenous ways of living have come to the fore in recent years. In 2015, both Canada and Australia have urged governments to acknowledge difficult histories such as residential schools and frontier violence in order to advance the process of reconciliation between Indigenous and non-Indigenous peoples. Similarly, in the Mariana Islands, scholars have focused on examining colonial impacts on Chamorro and Carolinian identity, largely in response to increased militarisation of the islands by the United States (U.S.) government. Examining the cultural identity of Indigenous peoples in the Marianas works to support Indigenous self-determination and resist further colonial actions by U.S. occupiers. Despite excellent work on Spanish and U.S. influences on Indigenous culture in the Marianas, little work has thoroughly examined the colonial cultural impact of the Japanese Empire in Micronesia. As a result, scholarship endorses a narrative that characterises Chamorro culture as a hybrid of Chamorro and Spanish or American cultural elements. Without an adequate analysis of Japanese colonial cultural impacts, we neglect to fully understand contemporary Indigenous culture in the Marianas Islands, which were occupied by three to four different colonial powers. My project begins to address this gap by analysing the material remains of Japanese colonialism in the Mariana Islands. Working with the community, my project will record materials and oral histories from the Japanese Period in order to understand Japanese influences on Indigenous culture. The project will further our understandings of Japanese imperialism, its effects on the people of the Mariana Islands and provide necessary analytical comparisons from a part of the Mariana Islands currently underrepresented in the literature. Furthermore, this work will contribute to a growing body of research on the ways Indigenous groups negotiated their identity during colonial periods.
Improving Aquaculture production with bioactives from olive oil processing by-products. (AQUOLIVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Natac Biotech S.L. is the R&D division of a group of 8 companies (Natac Group S.L.) with headquarters in Spain and international presence in LATAM and the USA. We are a leading biotechnology company specialized in the extraction of high added value bioactive ingredients from agriculture products. In our effort to continue innovating and expanding, the AQUOLIVE project was initiated a couple of years ago and it has become the most strategic project for us, as a way to become a leading player of the animal nutrition market. The AQUOLIVE project is aimed at offering the aquaculture sector a high-performance feed additive based on our patented formulation of bioactive phytochemicals obtained from olive oil production by-products (production method also patented). This solution will help Fish farmers to increase their productivity and profitability, while reducing the use of hazardous antimicrobial chemicals in intensive aquaculture practices. We see in the AQUOLIVE project a clear investment opportunity, in which we seek entering the fast growing aquaculture feeding market (estimated to reach €123 Billion by 2019) and achieve a 5-years cumulative cash flow of €18.23 Million meaning a 5-years ROI of 608%.

Keywords: aquaculture,fish feeding,natural extracts,circular bio economy
Plasma Reconnection, Shocks and Turbulence in Solar System Interactions: Modelling and Observations (PRESTISSIMO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2022-05-31
Duration (months): 72.0
Total project cost (EUR): 1998054.0
EU funding (EUR): 1904005.0
Participants: 2
Project status: CLOSED

This project combines the forefront space physics with top-tier high performance computing. Three phenomena are above others in importance in explaining plasma behaviour in the Solar-Terrestrial system, laboratories, fusion devices, and astrophysical domains: 1) magnetic reconnection enabling energy and mass transfer between magnetic domains, 2) collisionless shocks forming due to supersonic relative flow speeds between plasmas, and 3) particle acceleration associated with both. These processes are critical in understanding the scientific foundation of space weather, i.e., harmful effects caused by enhanced radiation and dynamical processes that endanger space- and ground-based technological systems or human life. Space weather forecasts require physics-based models; however, to date only simple plasma descriptions have been used in the global context. We have developed the first 6-dimensional global magnetospheric kinetic simulation in the world, Vlasiator, promising a grand leap both in understanding fundamental space plasma physics, and in improving the accuracy of present space weather models. Combining the unique Vlasiator with newest spacecraft data, local kinetic physics can be interpreted in global context in a ground-breaking fashion. We examine in the global and self-consistent context 1. Near-Earth reconnection, 2. Ion-scale phenomena in the near-Earth shocks, 3. Particle acceleration by shocks and reconnection, 4. Inner magnetospheric wave-particle processes, and the consequent particle precipitation into the ionosphere. The proposed work is now feasible thanks to increased computational capabilities and Vlasiator. The newest space missions produce high-fidelity multi-point observations that require directly comparable global kinetic simulations offered by Vlasiator. The proposing team has an outstanding record and a leading role in global space physics modelling.

Keywords: space plasma physics,solar wind,magnetosphere,ionosphere,space weather,kinetic global modelling,spacecraft observations,reconnection,shocks,particle acceleration,turbulence,storm,substorm
Multi-level Model Calibration for the Assessment of Historical Masonry Structures (MultiCAMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The MultiCAMS project will develop an advanced computational strategy including numerical modelling and innovative model calibration for realistic assessment of historical unreinforced masonry structures. The presence of relevant historical heritage in Europe, partly still in use, together with high seismic risk in the Mediterranean areas highlights the need of assessing such structures considering current safety requirements and if necessary strengthened to prevent critical failure. The proposed assessment approach is based on the use of models with different levels of sophistication, comprising detailed mesoscale models where masonry units and mortar joints are modelled separately (low level), homogeneous shell/solid-element models in which masonry is considered as a continuum (intermediate level), and efficient macroscale models where entire structural parts (i.e. piers, spandrels) are represented by appropriate macro-elements (high level). In this respect, I will develop a novel numerical description with macro-elements for an efficient and practical analysis of masonry structures accounting for the interaction between the nonlinear in-plane and out-of-plane behaviour of different URM components. An innovative model calibration strategy utilising inverse analysis techniques will thus be developed to couple the efficiency of the novel simplified mechanical model and the accuracy of existing detailed models, such as the parameters of each model will be determined from the inverse analysis of the numerical response of the lower-level model. The main outcome of MultiCAMS will be a comprehensive and accurate methodology for the seismic assessment of historical masonry buildings, which represents an urgent requirement for the safeguard of human lives in many European urban areas, as shown by recent catastrophic events.

Keywords: masonry structures,model calibration,numerical analysis,computational structural mechanics,inverse analysis,seismic assessment,testing
The Ocean's Oxygen Isotopes Deciphered: Combining Observations, Experiments and Models (OOID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 1490596.0
EU funding (EUR): 1490596.0
Participants: 1
Project status: SIGNED

The isotopic composition of O in seawater is a fundamental property of Earth's oceans, key to paleoclimate reconstructions and to our understanding of the origin of water on Earth, the water-rock reactions that govern seawater chemistry, and the conditions under which life emerged. Despite more than five decades of research, the geologic history of seawater 18O/16O remains a topic of intense debate. Without exception, well-preserved 18O/16O records from marine precipitates reflect both the minerals' formation temperature, and the isotopic composition of seawater. This duality has prevented unique interpretation of a long-term secular trend, in which 18O/16O in sedimentary rocks (e.g., carbonates, cherts) has increased by ~15 ‰ since the Archean. Here I outline an inter-disciplinary research program to address this fundamental problem, which integrates new geochemical observations, laboratory experiments, and numerical models. We will generate geologic records of 18O/16O in two previously untapped repositories: iron oxides and iron-bearing authigenic clays. Several characteristics of both, and preliminary results, suggest that these repositories hold the potential to settle the long-standing debate about seawater 18O/16O. We will determine the temperature dependence of mineral-water O isotope fractionation in laboratory experiments and observations of natural systems. We will experimentally test the resistance of these minerals to O isotope exchange under geologically-relevant conditions, with the aim of evaluating the potential for late-stage isotopic resetting. Finally, we will develop models of the marine O isotope cycle, which account for the processes that govern seawater 18O/16O over long timescales, and which will be used to provide a quantitative understanding of the new records. With these new insights, we will explore implications for the geologic history of seawater chemistry, atmospheric composition, climate and biology.

Keywords: earth systems evolution,ocean chemistry,oxygen isotopes
Queer Herstories of struggle and survival in Romania: From Communist criminalization to contemporary anti-gender movements in SEE spaces (Q-SEERA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: SIGNED

Q-SEERA, Queer Herstories of struggle and survival in Romania: From Communist criminalization to contemporary anti-gender movements in SEE spaces, is an interdisciplinary and novel research project which uses cutting-edge methodologies and adds unique knowledge that goes beyond the state of the art regarding queer (LBT+) women’s lives in SEE. By looking at a previously unresearched topic – the intimate and social lives of queer Romanian women under communism and during the ‘transitional 90s’ – and by comparing the results with research from the SEE region, the project explores how Romania stands out from other SEE and EU countries, unpacking differentiated inequalities across the region. It proposes new understandings of the rapid rise in anti-gender politics in Romania and other SEE countries through excavating novel knowledge on marginalized women’s lives, struggles and strategies of survival. This is done by gathering original and unique data from interviewing old(er) women, archival and text analysis through a micro historical approach, combined with a comparative analysis of gender norms related to sexuality in both communist and post communist Romania and the SEE. An innovative theoretical framework is developed in order to successfully deal with European challenges regarding policies and political discourses involving gender and sexual minorities, from a transnational perspective. This is achieved by connecting the ways in which the Romanian state enforced homophobia and sexism during communism and until its admission into the EU, looking at how these state-sanctioned social behaviors trickle until today, and by relating these findings on gender and sexuality with the roots of anti-gender movements in the SEE region. In the current context of rising threats against gender-related studies, academic freedom, minority rights and democracy, this project brings an essential and timely contribution to strengthening transnational and comparative regional studies.

Keywords: lgbt rights,queer studies,lesbian identities,anti gender movements,gender equality,transnational sexuality studies,contemporary history,south eastern europe see
Automated autologous cell therapy system (Project ACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Denmark
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-03-31
Duration (months): 8.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global burden of cancer, calculated as the cost of years lost from ill-health, disability or early death, currently outweighs all other health concerns including cardiovascular diseases . Among all cancers, metastatic melanoma (MM) represents one of the major health problems. Unlike other solid tumors, which mainly affect older adults, MM is notorious for affecting young and middle-aged people, results in 66000 related deaths yearly worldwide (World Health Organization) and therefore has a large impact on years of healthy life lost. Recently, promising results of autologous cell therapy (ACT) with tumour infiltrating lymphocytes (TILs) have shown that up to 20% of patients can be cured with one single course of this immunotherapy . This treatment has been conducted at a handful of institutions with over 1.000 patients treated worldwide. The resulting survival rates of patients treated confirm this approach as being among the most efficient therapies available. Importantly, this novel treatment has the potential to be expanded to the treatment of other cancer types. However, there is a need for dedicated bioreactors for the expansion of TILs for the individual patients. Bioreactors that can provide high cell densities and high absolute cell numbers. Further, TIL production for ACT is labour intensive and must be performed in a sterile cleanroom. This limits the use of this new and efficient cancer treatment to a few highly specialised hospitals. The aim of this application is to develop a dedicated bioreactor that will enable the treatment to be used on an extended number of hospitals. The commercial potential for ACT is estimated to be more than 4 Billion $ per year. . This project is therefore seen as relevant for the topic: Supporting innovative SMEs in the healthcare biotechnology sector - SMEInst-05-2016-2017 Publication date: 14 October 2015.

Keywords: autologous cell therapy
Clearing House for Knowledge Options (CHoKO) - creating a marketplace for knowledge (CHoKO)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Belgium
Call: SME business model innovation (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Knowledge and technology intensive (KTI) industries contribute >€15 trillion to the world economy. Yet there are no markets for knowledge itself, because there exist no common methods for valuing and therefore pricing knowledge. Instead, producers of knowledge, incl. experts and employees, sell their time at a fixed rate reflecting education and experience, but irrespective of value to their customers. Knowliah's Clearing House for Knowledge Options (CHoKO) fundamentally changes the way knowledge is valued and priced: CHoKO is an online platform tracking both production and use of knowledge, whose value is determined not at the point of exchange but at the point of (re)use; and producers get royalties in proportion to that value. This mirrors the role of Performance Rights Organisations (PROs) in the entertainment sector, who collect royalties from TV and music stations and distribute these to authors according to the playlists, i.e. actual use. Our ambition is for CHoKO to disrupt the traditional ways (i) for SME's to sell (and buy) their knowledge, (ii) to remunerate knowledge workers, artists, and social-profit workers, (iii) to value the knowledge equity of companies incl. start-ups, (iv) to manage intellectual property rights, and (v) to mitigate 'brain drain'. Revenues come from (i) licensing, implementing and operating the platform as stand-alone or shared service solution in companies - est. €5.4-54m by 2020; (ii) freemium membership fees from individual users - est. €9.6-15m by 2020; and (iii) commissions on royalties - est. €24-200m by 2020. The feasibility study will assess the project's viability: research and validate the legal foundations (with regard to privacy, data protection, and copyrights) for operating trans-nationally; assess, during a 6-month live pilot, factors that affect the rate and speed of adoption towards reaching critical mass among target communities; and identify and engage key international partners for commercialisation in Phase

Keywords: brain drain,intellectual property rights,knowledge,knowledge and technology intensive industries,options,price,royalties,value,valuation method