Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hybrid immune-eluding nanocrystals as smart and active theranostic weapons against cancer (TROJANANOHORSE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 1489219.0
EU funding (EUR): 1489219.0
Participants: 1
Project status: CLOSED

Nanomedicine tools for cancer treatment comprise many nanosized systems, so far developed with smart functions such as efficient drug delivery and cell targeting abilities. However they remain still undercharacterized in terms of immunogenicity, potential toxicity due to the materials itself or the unwanted release of drugs. To overcome these challenges this project aims to develop a new generation of multifunctional therapeutic and diagnostic (thus theranostics) nanosystems displaying non-immunogenicity, improved cancer treatment, cell imaging, and high safety for the hosting organism. The innovative concept behind this approach relies on a core-shell nanosystem with a therapeutically active core, i.e. a TrojaNanoHorse (TNH), here validated against leukaemia. The injectable TNH have a lipid bilayer shell derived from autologous cancer cell membrane, naturally non-immunogenic. The hemocompatibility, antithrombogenicity, and targeting ability with antibodies toward malignant blood cells will be proved during this project. Studies will show the zinc oxide nanocrystal core activation developing toxic reactive oxygen species (ROS) for cancer killing, and its green fluorescence emission. The whole TNH would go beyond the state-of-the-art due to its nature-derived biomimetic shell, absence of drugs, its safety and biodegrading fate, and green luminescent emissions for diagnosis. This project will also develop novel set-up for non-immunogenic therapy and diagnosis, impacting on future technology, new standardized protocols for nanomaterial safety assessment, and study chemical and biological mechanism of ROS development effects on cancer cell. Achieving the ultimate goal of a multifunctional TNH will require multidisciplinary expertise in chemistry, material science, biology, medicine and engineering, opening new horizons as nanomedicine tools for efficient cancer therapy with strong scientific, technological and socio-economic benefits.

Keywords: zinc oxide nanocrystal,exosome derived lipid shell,sonodynamic therapy,sonoluminescence
Development of a design-through-analysis methodology based on a coupled isogemetrcic-maximum entropy approach (ISOMAXENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Although from an historical point of view Computer Aided Design (CAD) and Numerical Analysis have always been two detached engineering disciplines, a lot of effort has been made over the last few years to seek a tighter integration between them. The recent development of Isogeometric Analysis (IGA) was one of the main achievement in this direction. The key idea of IGA is to use for the Analysis the same basis functions employed for the CAD representation, which in most of the cases are non-uniform rational B-splines (NURBS). However, the tensor product nature of NURBS poses some limitations in the trivariate volume parametrization of complex shapes and in local refinement, operations that are not needed for CAD purposes but are particularly important for the Analysis. This project aims at developing a coupled approach where IGA is blended with the Maximum Entropy meshless approximants, in order to overcome to such limitations, which prevents IGA to fully develop outside of the academic world into industry, and thus to create a design-through-analysis methodology with many potential industrial applications. Such methodology will be first developed for three-dimensional applications in the framework of NURBS boundary representations and then alternative frameworks, based on T-splines and subdivision surfaces, will be also explored. The application of the method to practical problems of industrial relevance will be then considered in detail. The programme will boost the career prospects, increase employability and widen the set of skills of the experienced researcher.

Keywords: isogeometric analysis,meshess methods,maximum entropy,design through analysis,computer aided engineering,computer aided design
Design Global, Manufacture Local: Assessing the Practices, Innovation, and Sustainability Potential of an Emerging Mode of Production (COSMOLOCALISM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Estonia
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1017275.0
EU funding (EUR): 1017275.0
Participants: 1
Project status: SIGNED

COSMOLOCALISM will document, analyse, test, evaluate, and create awareness about an emerging mode of production, based on the confluence of the digital commons (e.g. open knowledge and design) with local manufacturing and automation technologies (from 3D printing and CNC machines to low-tech tools and crafts). This convergence could catalyse the transition to new inclusive and circular productive models, such as the “design global, manufacture local” (DGML) model. DGML describes the processes through which design is developed as a global digital commons, whereas the manufacturing takes place locally, through shared infrastructures and with local biophysical conditions in mind. DGML seems to form economies of scope that promote sustainability and open innovation while celebrating new ways of cooperation. However, such claims rest on thin conceptual and empirical foundations. COSMOLOCALISM is a multiphase, pilot-driven investigation of the DGML phenomenon that seeks to understand relevant organisational models, their evolution, and their broader political economy/ecology and policy implications. Through the lens of diverse case studies and participatory action research, the conditions under which the DGML model thrives will be explored. COSMOLOCALISM has three concurrent streams: practices; innovation; and sustainability. First, DGML practices will be studied, patterns will be recognised and their form, function, cultural values, and governance structure will be determined. Second, the relevant open innovation ecosystems and their potential to reorient design and manufacturing practices will be examined. Third, selected DGML products will be evaluated from an environmental sustainability perspective, involving both qualitative and quantitative methods. The interdisciplinary nature of COSMOLOCALISM will explore new horizons to substantively improve our understanding of how we could do “more” and “better” with less.

Keywords: digital commons,open innovation,political ecology,open design,open hardware,technology governance,desktop manufacturing,sharing economy,cooperatives,post growth,social entrepreneurship
A new automated beekeeping platform based on AI, computer vision, and precision robotics, designed to improve bee health, and increase pollination and honey production (BeeHome)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 3145125.0
EU funding (EUR): 2201587.5
Participants: 1
Project status: CLOSED

Pollination is crucial to life on the planet. Bees and other pollinators have thrived for millions of years, ensuring food security and nutrition, and maintaining biodiversity and vibrant ecosystems for plants, humans and the bees themselves. Globally, 75% of crops producing vegetables, fruits and seeds for human consumption depend on pollinators for sustained production, yield, and quality. In recent years, most countries in the world have reported high rates of disorders affecting their honeybee colonies. The seemingly unpredictable loss of bee colonies exacerbates the shortage of pollinators, which reached an unprecedented global rate of ~30% compared to 2%-3% a couple of decades ago. The device beekeepers rely on to manage bees and take care of their ongoing upkeep is a wooden box designed 150 years ago, the beehive we’re all accustomed to seeing in the field. This “technology” does not allow beekeepers to maintain healthy bees in the face of modern challenges like pests, diseases, and climate change. Furthermore, this is the technology utilized to pollinate 75% of global crops for 7 billion humans, resulting in the most extreme pressure bees have ever experienced. Beewise developed the Beehome platform, which is a modular commercial AI-powered apiary composed of hardware and software that fully automates beekeeping while optimizing pollination and honey production. The technology is not exclusive to honeybees and can support various species of bees that face extinction as well. The platform includes an automated robotic brood box management system, a computer vision-based monitoring system, AI-based decision making, an automated honey harvesting system and systems for pest control, feeding, and thermoregulation. The key objectives of the project are to optimize the software and the AI, to finalize the engineering of the hardware components, to validate the technology in a two-stage in-field testing and to obtain the CE mark for commercialization in Europe.

Keywords: honey,beekeeping,automation,colony collapse disorder,artificial intelligence,varroa mite
First subcutaneous implant to treat lymphedema. Definitive solution for chronic lymphedema (LymphoDrain)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Switzerland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Lymphatica Medtech S.A. is a spin-off company created in 2017, from the Swiss Federal Institute of Technology in Lausanne (EPFL) and the Lausanne University Hospital (CHUV). It has designed and patented “LymphoDrain” a novel implantable system to replace the lymphatic vessel draining function to treat lymphatic disorders, in particular chronic lymphedema. It uses an underlying technology based on a magnetically controlled micro-pump coupled with draining catheters. LymphoDrain was developed by Dr. Marco Pisano and Dr. Valentina Triacca, in the Laboratory of Lymphatic and Cancer Bioengineering led by Prof. Melody Swartz. Since the initial invention, a multidisciplinary and highly qualified team has participated in the project bringing clinical perspective and attracting financial support from several organizations (CTI grant, FIT grant, AIT innovation grant). The recognition has been received at both national (Winner of Venture Kick stage I and II, Top3 at Venture Business Plan Competition 2016) and international level (finalist at Imagine IF Accelerator 2016, Top 2 at TERMIS-EU Business Plan Competition 2016). At the moment, Lymphatica is a finalist in the MassChallenge Switzerland Awards 2017 on a trajectory of unstoppable growth and recognition. LymphoDrain technology was consciously designed as an implantable system to cover the needs of a segment of the population, estimated at more than 15 million people in Europe and US who suffer of chronic lymphedema and presently lack effective treatments. The functionality of LymphoDrain has been successfully tested in large animal models. This vision positions LymphoDrain in a unique situation to access both the European and the US health care market as a disruptive technology in the treatment of lymphedema.

Keywords: active implantable device,chronic disease,draining function,lymphedema,lymphatic vessels,medical device
Autonomous Shipping Initiative for European Waters (AUTOSHIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Spain,Italy,Norway,Norway,Norway,Belgium,Belgium,Finland,Finland,Bulgaria,France,United Kingdom,United Kingdom
Call: The Autonomous Ship (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-06-01
End date: 2023-11-30
Duration (months): 54.0
Total project cost (EUR): 29546161.25
EU funding (EUR): 20109109.13
Participants: 18
Project status: SIGNED

While the shipbuilding market has been advantaging Asian lower-cost manufacturing in the last decades, AUTOSHIP will build around two EU industrial market and leading technology providers, such as Rolls Royce and Kongsberg, to create a stronger European cluster able to thrust a market worth Billions of Euros in the next decade, bringing new high-skilled jobs and a safer and greener transport in Europe. AUTOSHIP will build and operate 2 R&A vessels and their needed shore control and operation infrastructure, reaching and going over TRL7. Testing will take place during two pilot demonstration campaigns addressing goods mobility from the Baltic Corridor to a major EU seaport and hinterland, which are most relevant areas with growing waterborne transport market demand in EU. Doing so, it will speed-up the Next Generation of Autonomous Ships, by demonstrating in real environment Short Sea Shipping and Inland Water Ways autonomous vessels. The technology package will include full-autonomous navigation, self-diagnostic, prognostics and operation scheduling, as well as communication technology enabling a prominent level of cyber security and integrating the vessels into upgraded e-infrastructure. In parallel, digital tools and methodologies for design, simulation and cost analysis will be developed for the whole community of autonomous ships. AUTOSHIP will help ship operators/owners to improve the economy of scale of their investments, to effectively gain competitiveness and renew their fleets, making them more competitive to replace road transport. The project’s ambitions will leverage on advanced KETs, solid industrial, investment and business worldwide, participation in all major stakeholders’ organisations. The high ambition is to deliver the technology on the market in 5 years boosting ocean and intercontinental unmanned shipping. It is an ambition with a solid base in the involved value-chain and in the financial and commercial commitment discussed in this proposal.

Keywords: autonomous ship,short sea shipping,inland water ways,e navigation
PROcess intensification through the development of innovative MEmbranes and CAtalysts (PROMECA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Spain,Italy,Italy,France,Netherlands
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-10-31
Duration (months): 70.0
Total project cost (EUR): 688500.0
EU funding (EUR): 688500.0
Participants: 6
Project status: CLOSED

PROMECA strategic objective is to substantially contribute to the increase of knowledge, skills, and competitiveness in the European research area and industry, through the design and deployment of a thorough plan of research and secondment of researchers between top-level EU academia and industrial partners, contributing to the main European Policies on innovation. In line with the MSCA-RISE general objectives, the project will: • Support career development and training of 44 researchers through international and inter-sectoral mobility among 3 academia and 3 industrial partners in 4 European countries; • Promote sharing of knowledge and ideas from research to the market (and vice versa) in a systematic way, through the participation of researchers to 3 focused research groups where scientific and industrial mix of competences are ensured, and the organization of 8 project meetings, where research findings will be assessed and validated among groups. • Carry out a thorough training of researchers in 6 dedicated workshops, each with a different focus, also adding key entrepreneurial skills and innovation management. As an ultimate R&D goal, PROMECA will develop, test, and validate an innovative membrane reactor integrating new structured catalysts and selective membranes to improve the overall performance, durability, cost effectiveness, and sustainability over different industrially interesting processes, with distributed hydrogen production as the main focus of the project. The project will bring substantial impacts in terms of skills and knowledge development of the researchers, as well as higher R&I output, contributing to convert more ideas into products. Organizations involved will strongly boost their capacity to carry out R&I activities in multidisciplinary and inter-sectorial collaborations. Finally, the project will enhance the innovation potential and competitiveness of the EU industry, reinforcing its world leadership as a true knowledge-driven industry

Keywords: computational engineering and computer aided design,energy collection,conversion and storage,renewable energy,sustainable design for environment
Imaging Magmatic Architecture using Strain Tomography (MAST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France,Czechia,United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1995365.0
EU funding (EUR): 1919020.0
Participants: 3
Project status: SIGNED

Volcanic unrest can give warning of impending eruptions, thus monitoring and appropriate emergency management saves lives. However, the ability to accurately forecast the future behaviour of individual volcanoes relies on interpreting changes in the underlying magmatic system. The conceptual understanding of magmatic systems has evolved rapidly and there is now ample geophysical and petrological evidence that a fluid-dominated ‘magma chamber’ is only one component of a much larger system with a heterogeneous distribution of melts, crystals and gases. The opportunity exists to use these advances to interpret monitoring signals, to improve forecasting skills and in turn contribute to the paradigm shift in understanding. In particular, satellite technology has revolutionised the coverage, resolution and frequency of deformation measurements and is increasingly used for volcano monitoring. Dense time-series of high-resolution images reveal complexity and diversity than was not apparent when only infrequent point measurements were available. The latest images are more compatible with the paradigm of extensive multiphase, magmatic systems, but even the most recent models still rely on spheroidal chamber geometries. The aims of MAST are thus 1) to analyse and model volcano deformation independent of constraints on geometry or rheology and 2) to link the long-term evolution of the temperature and melt fraction to patterns of surface deformation. These aims capitalise on the rise of satellite data, and recent advances in machine learning, strain imaging and the modelling of multiphase systems. The outputs will provide a scientific basis for observatories to interpret signals observed during unrest and to forecast future activity. Most importantly, the outputs will be consistent with – and contribute to - the latest understanding of magmatic systems. This multidisciplinary proposal is inherently high risk, but builds on my experience leading a broad team of investigators.
Tailored Metal-Organic Framework: From Hybrid to Multifunctional Flame Retardant Polymer Nanocomposites (MOFMAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-09
End date: 2019-01-08
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The main objective of this work is to develop new generation polymer-based multi-functional nanocomposites by combining functionalized Metal-Organic Framework (MOF) and graphene hybrid into polymeric matrices via an innovative approach. In this work, MOF is employed to develop multfunctional flame retardant polymer nanocomposites for the first time. The environmentally friendly framework MIL-101-Fe is chosen as the host framework. By introducing functional groups into the framework, MOF particles can be combined with both graphene and polymeric matrices via chemical interaction, to construct polymer nanocomposites which have multi-functions including improved antistatic property, mechanical reinforcement, enhanced thermal conductivity and excellent flame retardant properties, simultaneously. By loading non-flammable gas and/or effective flame retardant into the pore system, MOF can serve as flame retardants container at room temperature. By hybridization with MOF, the intrinsic function of graphene such as electronic and thermal conductivities will be combined into the MOF/graphene hybrid. Far different from present flame retardant additives, in proposed polymer nanocomposites, functionalized MOF hybrid will hinder or slow down the combustion process in different format through the whole combustion process, surpassing other flame retardant systems. At the early fire stage (Ignition), the non-flammable gases stored in MOF will be released to delay the ignition; at the developing fire stage, the graphene layer and char formation will delay the time to developed combustion; at the developed fire stage, the catalytic effect of metal compounds generated by decomposed MOF will decrease the heat release rate, fire growth intensity, smoke production, etc. The new knowledge and new materials developed in this proposal has the promise to be applied in developing new generation products in the fields of the construction, transportation, aerospace, etc, in the future.

Keywords: metal organic framework mof,hybrid,flame retardancy,mulfifunction,polymer nanocomposites,flammability