Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Data-driven cancer genome interpretation for personalised cancer treatment (CGI-Clinics)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Spain,France,Germany,United Kingdom,Greece
Call: Data-driven decision-support tools for better health care delivery and policy-making with a focus on cancer (HORIZON-HLTH-2021-CARE-05, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 9584298.0
EU funding (EUR): 9584298.0
Participants: 19
Project status: SIGNED

CGI-Clinics aims at improving personalised medicine in oncology by optimizing genomic data interpretation (after sequencing and before advising on compatible targeted therapies). Interpretation is a bottleneck for the full deployment and broad accessibility of Next Generation Sequencing (NGS) in cancer management. The project tackles the 3 main hurdles in the interpretation of cancer mutations: it is not systematic, it deals with a majority of variants of unknown significance and it fails to empower patients. The interpretation of tumor genomic data relies on the work of experts reviewing scattered databases and resources, in a time-consuming process that may lead to suboptimal clinical decisions. CGI-clinics will systematize the interpretation process by integrating relevant public and private databases hospitals in a one-stop shop tool, with the possibility to organize virtual molecular tumor boards co-facilitated by reference hospitals. Project will have three phases: a setup (assess needs), validation (pilot with the 9 clinical partners) and replication (30 hospitals across EU). It will enable democratization of genomic data interpretation (independent of their size, resources and profiling technology) and provide health economics validation. Relying on a systematic automatic learning platform, GCI-Clinics will increase the share of interpretable variants in tumors (from the current 9-12% to at least 50%), and features that constitute biomarkers of drug response. The interpretation process is complex for most cancer patients, alienating them from knowledge of their illness. CGI-Clinics will build eduCGI, an app to help them understand the information gained through interpretation of their tumors, facilitating informed discussions with clinicians and sharing their data for research. Ultimately, the project is built to inform policy-makers on cancer management and empower patients.

Keywords: genomic data interpretation,personalized cancer medicine,patient engagement,variants of unknown significance,cancer patient empowerment,molecular tumor boards,targeted cancer therapy
Street Harassment as a Public Problem: The Circulation of Policy Frames and Solutions in Europe (HarassEU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: CLOSED

Supranational organizations working on street harassment face the challenge of developing initiatives to address this issue around the world, while considering local specificities in what exactly is locally understood to be the problem. An ethnographic study of the production and circulation of policy frames of and solutions to street harassment, HarassEU contributes to our understanding of how policies and frames travel, and how governmental and non-governmental organizations operating on a local, national, and supranational level negotiate the nature of a problem and how to address it. Based at KU Leuven’s Centre for Sociological Research, the project is supervised by Prof. Giselinde Kuipers, a renowned scholar in comparative and cultural sociology. It includes a secondment at the Laboratory for Interdisciplinary Evaluation of Public Policies at Sciences Po Paris supervised by Prof. Anne Revillard, an expert in public policy and gender. The empirical investigation concerns the production of policy initiatives within supranational organizations working on this issue in Europe, as well as how supranational, national, and local organizations interact through case studies of four national contexts: the Netherlands, Belgium, France, and Italy. Relating research in gender studies to scholarship in pragmatic sociology and political science on processes of politicization allows HarassEU to deliver innovative results not only with respect to our understanding of the problem of street harassment, but also to provide original contributions to scholarship on public problems and policy agenda formation, globalization and international circulation, and gender and ethnicity. The analysis of tensions that organizations operating on different levels encounter in interacting with each other provides the basis for policy recommendations on how to more effectively build transnational coalitions to combat street harassment and other social problems.

Keywords: policy,social problems,social movements,gender,pragmatic sociology,street harassment,eu,globalization
Skills2Capabilities (SKILLS2CAPABILITIES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Austria,Netherlands,Germany,Estonia,Finland,Norway,Italy,Bulgaria,United Kingdom,Korea, Republic of
Call: Conditions for the successful development of skills matched to needs (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2395213.55
EU funding (EUR): 2395213.55
Participants: 11
Project status: SIGNED

The Skills2Capability project is about understanding how skill systems across Europe can reduce the level of skills mismatch in their labour markets. It is recognised that future labour markets will be more mobile with more people moving between jobs, employers, and sectors more often. This poses a problem for training systems insofar as employers may be much less willing than in the past to fund and provide training because their chances of appropriating the return will have been reduced. The study is concerned with understanding how skill systems can better respond to meeting skill demands in a more fluid labour market environment. The starting point is that of considering whether there is a need to provide individuals with a wider range of capabilities to weather a greater range of labour market challenges than those faced by their counterparts from previous generations. Some countries have been able to use their skills systems to deliver more of these capabilities than others, though the impact of this on labour market transitions is uncertain (something the current study addresses). If skills systems are to confer skills on individuals which provide them with increased resilience and capability, then there is a need to know what those capabilities or skills are in practice. The research addresses this from both a demand side (what are the skills which are currently in demand and are likely to be so in the future?) and a supply side (to what extent are these capabilities reflected in VET programmes) perspective. The research will provide decision makers in government and education authorities with information which allows them to obtain a better understanding of how emerging skill needs - which meet the needs of both economy and society - can be met (essentially providing a methodology and a tool), along with detailed information about the content of those emerging skill needs and capabilities (i.e. detailed data on demand and supply).

Keywords: capabilities skills vocational education and training skill mismatches careers information advice and guidance
In vitro reconstitution of the initiation of mitophagosome formation (Mitophagy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: CLOSED

Mitophagy is a tightly controlled process in which dysfunctional mitochondria are isolated and selectively degraded by autophagy. Many cell types critically rely on this pathway and mitophagy is therefore essential to life. For instance, egg fertilization or red blood cell development would not be possible without mitophagy. The importance of mitophagy is further underscored by its many links to human disease, most evident by mutations in the protein kinase PINK1 and the E3 ubiquitin ligase Parkin, causing autosomal recessive Parkinson’s disease. While most factors required for mitophagy are known, a major outstanding question is: how do the different factors come together to produce a mitophagosome? As the process comprises many different factors, each with a unique role, this is a challenging scientific question to address. The goal of this project is to gain insight into this process, using biochemical reconstitution, to elucidate how more than 15 different factors work together to initiate the formation of a mitophagosome. A unique aspect about our approach is that it not only allows to elucidate how mitophagosome formation is initiated, it could also reveal additional layers of fine-tuning, for instance also explaining how mitophagy is prevented from being initiated too early. This project may therefore lead to a major step forward, establishing a coherent framework of how mitophagosome formation is organized. Moreover, it could lead to new avenues for treating devastating neurodegenerative diseases like Parkinson.

Keywords: mitophagy pink1 parkin selective autophagy optn ndp52 tbk1 lc3 in vitro reconstitution mitochondria mitochondrial homeostasis parkinson s disease
Plug-and-play sustainable dyeing solution to help the textile industry reduce energy costs and environmental impact (Ever Dye)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 4202165.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Textile and fashion brands face mounting pressure from national and international policies, consumers, and institutional investors to transform their practices and decrease greenhouse gas (GHG) emissions. Presently, textile dyeing methods are both energy-intensive, resulting in higher GHG emissions, and economically burdensome. Although sustainable dyes can reduce GHG emissions, they often come at a higher cost due to expensive materials, additional capital investments, or the need for high temperatures, leading to elevated energy expenses. Ever Dye has pioneered an innovative dyeing process with a biosourced pigment, effectively detoxifying the textile industry, diminishing GHG emissions, and significantly reducing energy costs by enabling dyeing at room temperature. This breakthrough allows dyeing houses and fashion brands to achieve substantial savings while adhering to the growing demand for emission reduction across the textile value chain. Ever Dye has already made considerable headway in the market and intends to carry out laboratory and industrial trials in partnership with several prominent fashion brands.

Keywords: textiles,fashion industry,sustainability,ghg emissions,dyeing
Advancing Subseasonal PredIctions at Reduced computational Effort (ASPIRE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1496246.0
EU funding (EUR): 1496246.0
Participants: 2
Project status: SIGNED

The new frontier for weather prediction is the so-called subseasonal time scale of two weeks to two months ahead. To take preventive measures at an early stage, reliable forecasts on this time scale are becoming increasingly important for multiple socio-economic sectors. Subseasonal predictability can be gained from recurring patterns in the Earth system. ASPIRE will focus on one of these, namely modes of tropical convective variability. Long-standing systematic errors due to the parametrization of processes in numerical weather prediction models prevent the predictability of these modes from being exploited. Simply running models at a resolution high enough to resolve tropical convection is not feasible due to high computational costs. Taking advantage of three recent developments, ASPIRE will explore new ways to better exploit the intrinsic predictability of tropical convective modes without exhausting the currently available computing resources. The uniqueness of ASPIRE is its cross-disciplinary approach that builds on my experience in atmospheric dynamics and predictability, numerical modeling, and machine learning (ML). First, ASPIRE will identify the source regions and pathways of tropical forecast errors that prevent the intrinsic predictability from being exploited using a new set of subseasonal ensemble hindcasts. Second, ASPIRE will quantify for the first time the added value of locally confined kilometer-scale resolution in the source regions identified before, and generate probabilistic predictions from deterministic forecasts through ML-based post-processing. Third, to enable simulations at kilometer-scale resolution in operations, ASPIRE will develop ML approaches that emulate the integrated effect of the resolved convection in the tropics at substantially reduced costs. If successful, this approach would be a breakthrough towards improved operational weather forecasts at substantially lower computational costs, for a global socio-economic benefit.

Keywords: subseasonal predictability numerical modelling tropical extratropical teleconnections
Development of myopathies in broiler chickens with a special insight into spaghetti meat (DEMyo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,United States,Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 6
Project status: CLOSED

To meet increasing demands for high-value proteins, broiler selection programs driven by growth rate led to the development of wooden breast (WB), white striping (WS), and novel emerging and unexplored myopathies such as spaghetti meat (SM). In light of the current situation DEMyo project will address important questions in today's myopathies research: is it possible to detect myopathies in birds early age? Are there early differences between animals that will show myopathies at slaughter and the others or not? What’s the difference among animals developing WS, WB and SM? The novelty of the present proposal lies in the innovative application of advanced methodologies based on omics platforms to understand the molecular mechanism involved in the development of broiler myopathies in both sexes. The added value of the project is in assessing if nutritional manipulation with Na-butyrate might be used as a feeding strategy to decreases the occurrence of SM. The project will be developed for 2 years by means of 6 WPs. Candidates diverse scientific background in food science and veterinary medicine and advanced training from BCA and DAFNAE departments (UNIPD) reinforced with secondments at the University of Bologna, Universitat Politecnica de Valencia and Wisconsis-Madison under supervision of the leading experts in the field will maximize the success of the research project and the candidate’s career goals. Communication, dissemination and results exploitation will be addressed to multiple stakeholders by different tools at national, EU and international levels. Results from this multidisciplinary project will have a scientific impact with novel information about myopathies to be adopted in the practice while meeting SDG 1, 3, 5, and 12, improving animal welfare, meat quality, and mitigating economic losses. MSCA project will be a career breakthrough, help the candidate established a position in the field, empower her role as a female scientist and provide her with skills and opportunities for further grants.

Keywords: broilers,myopathies,omic,next generation sequencing,meat quality,feed,sodium butyrate
High performance hydrophobic suberin nanoparticles for the generation of liquid-air biphasic droplets with application in food and therapeutics (SNAIL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

An antibubble is a droplet of liquid with a shell surrounded by a thin film of gas. Antibubbles have many potential applications, e.g. drug delivery with application in a clinical setting and the food industry. The major challenge is to develop antibubbles with a long life time; essential for industry usage. The gas shell can be stabilized using hydrophobic nanoparticles to create a particle shell surrounding the air. The use of particles, instead of surfactants, to stabilize dispersed systems is an attractive sustainable solution for the food industry. Our demonstration of the ionic liquid-catalyzed purification of the polyester suberin - from plant materials in the form of hydrophobic nanoparticles led us to investigate their potential application for the generation of high performance antibubbles.

Keywords: plant polyesters suberin hydrophobic nanoparticles pickering antibubbles food grade ingredients
Identifying Constraints: Ancient protein characterisation to Reveal past Human Subsistence adaptations to climate change (ICARHUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-03-31
Duration (months): 31.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Facing the constraints imposed due to climate change is a challenge past human societies had to take into consideration, similar to how current societies are facing global changes in resource availability and climate change. By looking into the past and how ancient societies adapted to temperature increase and water availability decrease could help us to innovatively deal with the current climate crisis. In the Levant, where cattle, pigs, sheep and goat have been domesticated, ecological constraints are one of the major reasons for observed changes in subsistence strategies. Traditionally, comparative anatomy of fauna remains is the methodology of choice when aiming to reconstruct past subsistence strategies. But in arid environments, archaeological bones and teeth degrades rapidly, leading to highly fragmented and poorly preserved remains, thus largely restricting faunal spectra reconstruction. This project offers a glimpse at past Levantine societies adaptation to climatic pressures by using the new and exciting field of palaeoproteomics. The fellowship will concentrate on three defined scientific objectives: 1. enhance the available protein reference sequences, crucially lacking Near-Eastern wild ungulates species; 2. identify subsistence strategy shifts along four Jordanian archaeological sites, each containing well-established stratigraphies, using ancient proteins based species identification; and 3. recover information regarding sex-driven husbandry practices in caprine herds using the new method of enamel proteome sexing. The combination of archaeology and biological sciences within the frame of ICARHUS will give the opportunity to get a glimpse into past human societies agro-cultural behaviour using methodological developments of use beyond the field of bio-archaeological sciences.

Keywords: palaeoproteomics levant jordan natufian neolithic subsistence strategies