Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deconstruction of complex crosslinking damage (DECONSTRUCT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Cells are constantly challenged by complex crosslinking damage, which is caused not only by endogenous metabolites, such as reactive aldehydes, but also by various exogenous sources. While crosslinking damage to DNA has been studied extensively, almost all reactive agents act pleiotropically and also damage RNA and proteins. However, due to the complexity of the damage, it is difficult to determine which components of the damage are responsible for specific cellular outcomes. Therefore, it is unknown how crosslinking damage to RNA and proteins affects cellular homeostasis and how it is detected and resolved. Here, I propose to exploit novel experimental model systems that deconstruct complex crosslinking damage into distinct toxic components. I will combine metabolic labelling with photoactivatable-crosslinking approaches to mimic aldehyde-induced RNA or protein damage in the absence of DNA damage. We will combine these model systems with genetic and proteomic approaches to define the molecular mechanisms that detect and resolve RNA-protein crosslinks and protein-protein crosslinks. To this end, we will capitalize on preliminary work indicating the existence of an entirely uncharacterized translation-coupled quality control mechanism that ubiquitylates and degrades proteins crosslinked to mRNA. Ultimately, I will build on these mechanistic insights to explore the physiological role of RNA and protein damage in (1) the response to endogenous formaldehyde generated during cellular differentiation and (2) the mechanisms-of-action of chemotherapeutic crosslinkers. My work will provide a comprehensive view on how complex crosslinking damage affects cellular homeostasis and will challenge the current paradigm that DNA damage is solely responsible for the cytotoxicity of crosslinking agents. As such, my work will address a major blind spot in the fields of cellular quality control and genome stability with wide-ranging implications for cancer therapy and ageing.

Keywords: genome stability,dna damage,dna protein crosslinks,dna repair,mrna damage,ribosome quality control,protein quality control,proteostasis,ubiquitylation,stress
Development of Advanced Thermometric Nanomotors (TherMotors)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-17
End date: 2026-07-16
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Temperature is a central concept in thermodynamics and is one of the most crucial parameters to be described in scientific and technological achievements. Due to the high importance of measuring this property, thermometers are accounted for ≈ 80% of the sensor market and could reach 6.86 billion USD in 2023 according to a study done by Grand View Research, Inc. Since technology is advancing in miniaturizing devices and scientific interest in nanoscale structures and phenomena is increasing, the need for new thermometric sensor platforms is surging since regular thermometers are limited to tens of micrometers size range. Additionally, a remote way to control their position has not been realized. Therefore, the development of a thermometer working on the nanoscale with a precise position control is highly desired. Nano/micro-motors are particles capable of realizing motion through external stimuli, and they can be spatially and temporally controlled remotely, thus opening new possibilities for sensor technology. In TherMotors, we propose combining the self-propulsion of photoactive nanomotors with the thermometric properties of lanthanoid-doped nanocrystals to obtain advanced functional nanodevices that can move when excited by an UV source, while IR excitation will allow for measuring temperature in the surroundings. In this way, a great scientific development will be made in allowing temperature to be measured remotely in a small size scale and, at the same time, allow the precise control of the region in which the temperature will be measured.

Keywords: micro nanomotors,upconversion,thermometry,sensors,lanthanoids,zno,janus particles
Field Trials beyond 5G (FIDAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Cyprus,Greece,Italy,Spain,Norway,France,Belgium,Switzerland
Call: SNS Large Scale Trials and Pilots (LST&Ps) with Verticals (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 17290100.0
EU funding (EUR): 14974567.0
Participants: 22
Project status: SIGNED

Long-term towards Evolved 5G and 6G research needs mobilization of massive volumes of ideas, from which the best can emerge and be taken into standardization. It is the convergence of the cyber and physical worlds that could be achieved with the very low latency and high data capacity of Beyond 5G and 6G networks and thus the creation of services such as digital twins and internet of senses/haptic applications. This future eco-system is on course to be more collaborative and inclusive than previous generations of network, and FIDAL aims to lead the way by promoting open architectures, large experimentation sites and taking a multi-stakeholder approach. FIDAL steps in, targeting the augmentation of human capabilities, allowing Media & PPDR vertical industry players to perform advanced technological and business validation in large-scale field trials of highly innovative and advanced applications, that exploit Evolved 5G technologies. This, in turn, will provide extensive and valuable feedback to the broader industry, academia, innovators and community before wide commercial deployments of Evolved 5G networks throughout Europe. FIDAL key objective is to extend and deliver (i) advanced future proof Evolved 5G test infrastructures, anticipating evolution into next SNS phase, (ii) open & accessible to support 3rd party vertical experiments, (iii) test environments for rapid prototyping and large-scale validation of advanced, forward-looking applications. The project will build on the success of 5G-PPP Phase 3 projects, producing a unified experimentation framework with Zero-Touch orchestration, reusable Network Applications and secure AI as a Service capabilities. FIDAL will deploy 3 testbeds and 3 large-scale test infrastructures in Greece, Norway and Spain aiming to validate Evolved 5G technologies in a user context to maximise downstream take up, thus cultivating the ground for 6G.

Keywords: evolved 5g large scale media and ppdr test infrastructures
SisTemic mUltilevel optimized orchestratioN of energy maNagement systEms for resiDential, industrial and tertiary energy flexibility services (STUNNED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Italy,Spain,Serbia,France,Germany,Türkiye,Portugal
Call: Energy Management Systems for flexibility services (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-11-01
End date: 2028-04-30
Duration (months): 42.0
Total project cost (EUR): 6409774.43
EU funding (EUR): 4998971.88
Participants: 18
Project status: SIGNED

STUNNED project aims to reduce the overall energy demand of groups of end-users (buildings) aggregated in energy communities or energy districts, integrating renewables, electric vehicles, different proprietary EMS, ensuring stability in connections with the main electrical grid and providing ancillary services such as Demand Response (DR), peak shaving, load shifting, balancing&frequency services, congestion management. Through the aggregation of multiple residential/industrial buildings, STUNNED aims to demonstrate the opportunity to provide energy flexibility services to the electricity network and to facilitate aggregated prosumers, consumers and producers joining the electricity markets. The proposed solution will be based on the Stackelberg Game optimization method, a mathematical technique capable to find the optimal trade-off solution between two different local actors in a three layer configuration: the “middle layer” actor, represented by the Aggregator, and a “lower layer” actors, represented by the group of buildings/industrial sites which will capitalize the possibility to reduce their costs and carbon footprint enabled to the participation in energy and flexibility markets, the “upper layer” actor. Three different schemes will be implemented and compared, addressing three main market configurations (centralized, decentralized, distributed). Techno-economic-legal viability of the proposed solution will be validated through a demonstration campaign in three different EU countries (Italy, Spain and France), also involving local TSOs/DSOs either directly or through the existing markets. Replication and market design and exploitation will be one of the core points of STUNNED concept development. Moreover, STUNNED will develop a solution coherent with the on-going regulatory framework and providing recommendations for enhancing and innovating the current energy communities legislation.

Keywords: energy communities,aggregator,res,tso,dso,interoperability,flexibility services,cybersecurity,optimization control alghorithm,home appliance producers,bmss,emss
Space-Time and Vectorial Meta-Optics for High-Power Structured Laser-Matter Interactions (metaPOWER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499789.0
EU funding (EUR): 1499789.0
Participants: 1
Project status: SIGNED

Plasma is an extreme form of matter at the heart of important applications like fusion and particle acceleration. The creation and control of plasma require high-power lasers, now increasingly within reach, often operating at terawatt or petawatt levels. One of the six grand challenges in Plasma Science and Engineering is mastering the art of molding plasmas with lasers, yet a gap exists: the need for advanced beam control at high power levels. metaPOWER aims to fill this gap by developing high-damage-threshold metasurfaces—the state-of-the-art nanotechnology in structured light—for high-power lasers. These metasurfaces will be integrated in innovative laser beam shapers, offering spatiotemporal and vectorial (polarization) control over laser beams, thus making a leap over the state of the art, which is currently limited by the lack of advanced high-power optics. The project will demonstrate the ability to seed and control laser-plasma instabilities via reconfigurable vector beams, and to create topology-controlled wakefield acceleration and tunable X-ray and THz-to-xUV sources based on space-time beams with orbiting pulses. This marks a paradigm shift in laser-matter interactions, enabling new possibilities in fusion energy, particle acceleration, and radiation sources. Feasibility is backed by solid preliminary results, including successful structured laser-plasma simulations, a demonstrated scheme for the synthesis of space-time beams, and initial metasurface fabrication resilient to high-power lasers. The implications of metaPOWER's success extend far beyond the groundbreaking objectives of this proposal. These transformative technologies may catalyze advancements in quantum plasmas, laser material processing, high harmonic generation, and the development of a new class of polarization plasma optics, opening up new horizons in high-power structured laser-matter interactions.

Keywords: structured light metasurfaces high power lasers space time beams vector beams structured plasma laser plasma instabilities
NTase Products and Cyclic Nucleotide Signalling (NTasePro)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1755873.0
EU funding (EUR): 1755873.0
Participants: 1
Project status: SIGNED

Survival of a cell depends on its ability to receive and process information coming from the environment. Second messengers are the key transmitters of information that rapidly amplify the signal inside the cell. Cyclic nucleotides (CNs) are the most diversified category of second messengers and are found in all organisms modulating diverse pathways. CNs are best studied in bacteria, where they have a variety of biological functions. In humans, the only described cyclic di-nucleotide is cGAMP, which elicits an antiviral immune response. cGAMP is rapidly emerging as a promising drug candidate in e.g., cancer immunotherapy. I hypothesise that additional CNs contribute to yet uncharacterized pathways in humans and my aim is to discover novel CNs and their signalling pathways. CNs are synthesized by nucleotidyltransferases (NTases) and many human NTases remain uncharacterized by the lack of activity in the absence of the cognate ligand. This project aims to reveal the molecular function of uncharacterized NTases and to discover novel CN signalling pathways in humans in immune and non-immune-related areas of biology. I will focus in Objective ❶ on the activation of as yet uncharacterized NTases and in Objective ❷ I want to identify CN signalling pathways involved in immune responses and beyond. The proposed experiments will provide me with candidates and precedence for CN signalling in humans other than cGAMP. The concept that yet uncharacterized CNs are involved in immune signalling as well as other pathways is highly innovative. Together, the well-studied activities in bacteria and the overall conservation of NTases in humans, further support fundamental involvement of CN signalling in humans. My proposed research will open up conceptually new modes of regulation in human biology, reveal novel signalling pathways and in the long-term contribute to new therapeutic options using CNs as drugs.

Keywords: nucleotide based second messengers,cgamp,cgas sting,nucleotidyltransferases,signal transduction,innate immunity,cyclic nucleotides
Quantum Computational Fluid Dynamics (QCFD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Greece
Call: Strengthening the quantum software ecosystem for quantum computing platforms (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-02, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 4935146.25
EU funding (EUR): 4935143.25
Participants: 8
Project status: SIGNED

Scientific and technological progress is broadly underpinned by the ability to accurately predict and optimise complex fluid flows which arise across the physical and life sciences including climate research, as well as in the energy, chemical, automotive, aircraft, and ship building industries. The wide separation of length and time scales that need to be covered when designing and optimising flows and a large number of design parameters make numerical simulations highly demanding. Current capabilities are thus insufficient to meet future demands of users in academia and industry. We will tackle this challenge by developing a quantum software framework for solving a wide range of industrially relevant computational fluid dynamics problems. This will consist of platform-independent quantum algorithms and hardware optimized software for platforms in the European Quantum Technology Flagship Projects. Tensor-network simulations, gate-level classical simulations including realistic quantum noise models, and implementations on quantum hardware will provide detailed information on quantum hardware requirements, achievable quantum advantages, and provide feedback to hardware developers. The quantum software will be verified and benchmarked against standard computational fluid dynamics results. It will be developed in agile cycles to respond quickly to user demands and progress in the quality of quantum hardware. We will demonstrate the feasibility and advantages of the quantum approach starting from a core set of highly scalable and industrially relevant design examples arising in the thermal management of battery-electric-vehicles aimed at increasing their efficiency. Subsequently, we will extend our approach to a wider class of fluid flows and industry partners. We will create an interface between the quantum software framework and the industry standard computational fluid dynamics software OpenFOAM to make it widely available and maximise its impact.

Keywords: computational fluid dynamics battery electric vehicles battery cooling variational quantum algorithms quantum software optimization industrial design
Design of New Enantioselective Decarboxylative Cross-couplings (DECross)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-15
End date: 2027-09-14
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

Carboxylic acids are widely found in commercialized chemicals and in naturally occurring compounds. Therefore, much attention is given to their catalytic activation, which over the last years resulted in the development of a variety of new synthetic methods. Among these, transition metal catalyzed decarboxylative cross-couplings (DCCs) are class of reactions that attracted significant interest in organic chemistry. These involve the activation of the substrate by removal of the carboxyl group as a molecule of CO2, and coupling of the formed metal-C bond with an electrophilic reaction partner to form a new C-C bond. However, despite the utility of this strategy, synthetic applications are limited due to the intrinsic stability and poor reactivity of carboxylic acids. In particular, this field is dominated by the DCC of benzoic acids, and aliphatic carboxylates used in transition-metal-catalyzed polar DCCs are limited to only two classes: i) α-aryl-acetates or ii) β-carbonyl acids. Moreover, enantioselective DCCs are rare, and controlling the stereochemistry at the carbanion site has never been reported. This proposal introduces an innovative activation mode for allyl and propargyl carboxylates towards novel (enantioselective) DCCs. This is enabled by a mechanistically unique decarboxylation step hat leads to the formation of allyl- and propargyl-metal intermediates capable of undergoing (enantioselective) alkylation of carbonyl compounds thus providing new C-C bond disconnections with wide applicability in organic synthesis. This proposal is set to provide new general knowledge in the catalytic activation of carboxylic acids and in their synthetic exploitation, which is a timely challenge. By unveiling a new DCC manifold and applying this to new enantioselective transformations, we aim to take DCCs to an applicative level, resulting in a significant breakthrough in the fields of transition metal catalysis and organic synthesis.

Keywords: decarboxylative cross coupling,asymmetric catalysis,transition metal catalysis
STructured unconventional reactors for CO2-fRee Methane catalytic crackING (STORMING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Denmark,Belgium,Netherlands,Luxembourg,United Kingdom,Slovenia
Call: Methane cracking to usable hydrogen and carbon (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 3125714.75
EU funding (EUR): 3125714.75
Participants: 15
Project status: SIGNED

STORMING will develop breakthrough and innovative structured reactors heated using renewable electricity, to convert fossil and renewable CH4 into CO2-free H2 and highly valuable carbon nanomaterials for battery applications. More specifically, innovative Fe-based catalysts, highly active and easily regenerable by waste-free processes, will be developed through a smart rational catalyst design protocol, which combines theoretical (Density Functional Theory and Molecular Dynamics Calculations) and experimental (cluster) studies, all of them assisted by in situ & operando characterisation and Machine Learning tools. The electrification (microwave or joule-heated) of structured reactors, designed by Computational Fluid Dynamics and prepared by 3D printing, will enable an accurate thermal control resulting in high energy efficiency. The project will validate, at TRL 5, the most promising catalytic technology (chosen considering technological, economic, and environmental assessments) to produce H2 with energy efficiency (> 60%), net-zero emissions, and decreasing (ca. 10 %) the costs in comparison with the conventional process. The dissemination and communication of the results will boost the social acceptance of the H2-related technologies and the stakeholder engagement targeting short-term process exploitation and deployment. The key to reach the challenging objectives of STORMING is the highly complementary and interdisciplinary consortium, where basic and applied science merge with engineering, computer and social sciences.

Keywords: methane