Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of fully dissolvable devices and application as implanted neuroprostheses (Edible Neuroprosthetics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Restoring sensory and motor human functions is the main goal of Neuroprosthetics. The development and integration of artificial devices with neural tissues is therefore a very important research branch, which aims at improving the quality of human life. Recently, many advances have been made in this field by exploiting implantable organic devices able to accomplish a specific task inside the biological environment and last as much as possible before being removed. Within this scenario, the project aims at pushing the current state-of-the-art of Neuroprosthetic further by implementing a concept of ‘Edible Neuroprosthetics’, which consists in bio-electronic devices able to be literally digested by the cellular environment of the host after they have achieved their target. Novel fully biodegradable microelectrode arrays will therefore be fabricated on flexible substrates by implementing highly biocompatible and edible materials with innovative soft fabrication techniques. Their deterioration rate and change in the mechanical and electrical properties will be assessed with in-vitro ageing studies, followed by in-vivo tests in order to supply a proof-of-principle for future clinical applications. The inter-disciplinary and innovative aspects of the project will have a profound effect on the personal scientific background of the applicant as well as on her future career as independent researcher. The new skills she will acquire together with the new techniques she will learn and the wide scientific network she will actively be involved in will contribute to the formation of a strong and versatile research figure in Neuroprosthetics. Moreover, the results will provide unprecedented insight within the edible device concept, therefore making an important breakthrough, which will direct the Neuroprosthetic world towards less invasive bio-implants.

Keywords: organic bionics,neuroprostheses,bioelectronics,dissolvable neuroprostheses,bioresorbable device
Matrix Optimization for Testing by Interaction of Virtual And Test Environments (MOTIVATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Switzerland,Greece,United Kingdom
Call: Testing matrix optimization by interaction between numerical modelling and innovative non-contact measurement technology (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 741851.25
EU funding (EUR): 492876.0
Participants: 4
Project status: CLOSED

A significant step change is proposed in the way virtual and test environments are used together in an industrial environment to reduce the cost, risks and time associated with product development. Enabling technologies, which have been demonstrated in laboratory conditions during a series of EU FP 5 and 7 projects, will be transitioned into the industrial environment and demonstrated in a structural test on an aircraft subcomponent. In more detail: approaches to quantifying uncertainty in measurements of displacement and strain fields obtained using digital image correlation will be reviewed and a simple-to-use, robust methodology developed for use in industrial environments, with attention paid to the need to consider the entire measurement volume as well as within the same timescale as a structure test. In addition, recent advances in the validation of simulations, using image decomposition to compare predicted and measured data fields, will be incorporated into advanced structural test protocols taking account of uncertainties to provide statements on the extent to which the predictions represent reality, i.e. the validity of the simulations. Best practice guidelines will be developed to allow the test matrix to be optimised thus minimizing the cost and time required for tests while maximising the reliability and credibility of the simulations. The proposed research represents a significant and generic advance in the technologies and methodologies used to validate computational models of structures that will benefit a wide range of industrial sectors, including the aerospace industry where it will support the introduction of disruptive technologies, such as highly integrated structures, by enabling high fidelity simulations. A strong programme of exploitation and dissemination is proposed using traditional routes as well as digital shorts, webinars, and a blog as well as workshops linked to the revision of the prenormative document published by CEN.

Keywords: validation,simulation,experimental stress analysis,uncertainty quantification,digital image correlation,aircraft structures,structural components,finite element modeling
Advanced XFEL and Synchrotron based Probes of Protein Structure and Dynamics (X-probe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy,Italy,Sweden,Sweden,Sweden,Switzerland,France,France
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 2331284.76
EU funding (EUR): 2331284.76
Participants: 11
Project status: CLOSED

This cross-disciplinary Marie Curie Innovative Training Network builds upon the transformative opportunities created by existing X-ray sources and new sources soon to be operative in Europe. These opportunities include using ultrafast X-ray sources to extract time-dependent structural information from proteins; and revolutionary possibilities created by X-ray Free Electron Laser radiation for an entirely new regime of pre-damage serial femtosecond crystallography. No lag should exist between building new sources and training the next generation of scientists well versed in using these facilities. Our research training will yield new scientific insights on fundamental properties of protein structure and dynamics: one of the most challenging problems in structural biology; and technological advancements in diverse fields from pharmacology to nanotechnology. X-probe creates close interdisciplinary collaboration between structural biologists, physical chemists, beamline engineers, software developers, and industrial partners. The rapidly changing state-of-the-art demands that young researchers are trained to meet these new experimental, technical and analysis challenges at the forefront of structural biology and photochemistry. X-probe’s interdisciplinary and intersectorial training network incorporates four leading European X-ray facilities (ESRF, MAXIV Laboratory, European XFEL, SwissFEL); three academic laboratories at the forefront developing X-ray tools to probe protein dynamics; and both large and small industrial partners. Four principal scientists in X-probe are female. X-probe builds close cooperation between traditionally separate fields of research at the very cutting edge of structural biology and creates a visionary training network that would not be possible within any of the individual partner states.

Keywords: ultra fast protein structural dynamics,serial crystallography,protein nanocrystals
Novel, highly effective and selective anticancer metallodrugs (TSPO METALLODRUGS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Dr. Leila Tabrizi, an Iranian national, is making an application to this programme to carry out a 24 months project in the area of medicinal chemistry in the group of Dr. A. Erxleben at the National University of Ireland, Galway. The objective of this proposal is the synthesis of novel gold anticancer drugs that simultaneously target two mitochondrial proteins that are associated with cancer progression. Gold(III) complexes will be designed that recognize the translocator protein which is overexpressed in various tumour types and that release the metal upon intracellular reduction to gold(I), a known inhibitor of thioredoxin reductase. Binding of the carrier ligand to the translocator protein and inhibition of thioredoxin reductase will induce cell death pathways in a synergistic manner, thus leading to highly effective and selective anticancer action. Detailed in vitro biological studies will be performed to evaluate the potential of the new anticancer drug candidates, to establish structure-activity relationships and to fully understand their mode of action. The researcher has already an excellent background in coordination chemistry and this project will allow her to deepen and expand her skills in synthetic chemistry, to enter into the biological field by receiving relevant training in cell and biological techniques and to establish important academic and industrial collaborations. The researcher who has recently been awarded a Government of Ireland Postdoctoral Fellowship proposes to carry out further research training at NUI Galway which is strategically developing strength in Biomedical Research and Cancer, one of the most important and challenging branches of Chemistry/Biochemistry in Europe. NUI Galway will also provide training in transferable skills and mentoring to the researcher. Both the scientific and personal training will contribute to her personal development and will allow her to reach professional maturity as an independent researcher.

Keywords: gold,anticancer,target delivery,antimitochondrial
Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe (SERA)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Germany,Italy,Italy,Norway,Türkiye,Greece,Greece,Poland,Sweden,North Macedonia,Belgium,Greece,Poland,Romania,Norway,Switzerland,France,France,France,France,France,France,France,Netherlands,United Kingdom,United Kingdom,Portugal,Portugal,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2016-1, 2016)
Start date: 2017-05-01
End date: 2020-04-30
Duration (months): 36.0
Total project cost (EUR): 11090779.02
EU funding (EUR): 10000000.0
Participants: 40
Project status: CLOSED

SERA is the "Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe", responding to the priorities identified in the call INFRAIA-01-2016-2017 Research Infrastructure for Earthquake Hazard. The overall objective of SERA is to give a significant contribution to improve the access to data, services and research infrastructures, and deliver solutions based on innovative R&D in seismology and earthquake engineering, aiming at reducing the exposure of our society to the risk posed by natural and anthropogenic earthquakes. To this end, SERA will: Involve the communities involved in previous successful projects including NERA and SERIES; Offer transnational access to the largest collection of high-class experimental facilities in earthquake engineering; Offer virtual access to the main data and products in seismology and anthropogenic seismicity; Promote multi-disciplinary science across the domains of seismology, anthropogenic seismicity, near-fault observatories and deep underground laboratories, to achieve an improved understanding of earthquake occurrence; Revise the European Seismic Hazard reference model for consideration in the ongoing revision of the Eurocode 8; Develop the first comprehensive framework for seismic risk modeling at European scale; Develop the new standards for future experimental observations in earthquake engineering and for the design of future instruments and networks for observational seismology; Develop reliable methodologies for real-time assessment of shaking and damage; Expand access to seismological observations; Network infrastructures and communities in the fields of deep seismic sounding, experimental earthquake engineering and site characterization; Provide an important contribution to the construction and validation of EPOS; Provide effective communication and outreach to all stakeholders.

Keywords: seismology,earthquake engineering,seismic hazard and risk,anthropogenic seismicity,deep underground,earth structure,georesources,geohazards
Electrical control of magnetism in multiferroic 2D materials (EMAGIN2D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2025-03-31
Duration (months): 76.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The avenue of magnetism in the field of 2D materials has marked the ultimate milestone in the discovery of one-atom-thick classes of materials. Bulk ferromagnets and antiferomagnets now have their 2D counterparts and are at one’s provision for the realization of imagination-limited artificial layered structures. At the same time, this awaited breakthrough has brought in new conundrums that demand investigation. This project is driven by the exploration of the limits of van der Waals 2D magnets from both a fundamental physics and a materials science and devices point of view. Firstly, it addresses fundamental key questions regarding spin order at the true 2D limit, which remain a mystery to the date. Here, the great variety of magnetic anisotropies exhibited by the transition metal halides will shed new light to the subtle equilibrium of interactions in few-layer magnets. Secondly, the project will invoke the control of the magnetic ground states and spin textures in true 2D magnets via electrical manipulation. Electric fields will assist in tuning the magnetic coupling and critical behaviour and the spatial manipulation of spin topologies. Anticipated breakthroughs will be the enhancement of the critical temperature in semiconducting single layer magnets towards room temperature 2D magnetism and the realization of single-layer multiferroic 2D materials. Thirdly, the field effect electrical control of magnetism in designer van der Waals and lateral heterostructures will allow for an enhanced magneto-electric coupling, yielding functional devices for effective charge-to-spin transduction that hold promise in spintronics. The proposal will achieve success by an integral approach to research, through the combination of the study of solid-state growth techniques together with the implementation of state-of-the-art deterministic manipulation of 2D materials in inert conditions and the use high resolution magnetism probes to test hybrid magnetic-optoelectronic devices.

Keywords: multiferroics,2d materials
European Connected Factory Platform for Agile Manufacturing (EFPF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Austria,Germany,Italy,Germany,Germany,Spain,Spain,Italy,Greece,Romania,Greece,Türkiye,Sweden,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Digital Manufacturing Platforms for Connected Smart Factories (H2020-DT-2018-1, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 16245127.63
EU funding (EUR): 13640264.01
Participants: 35
Project status: SIGNED

The EFPF project realises a federated smart factory ecosystem by primarily interlinking 4 smart factory platforms, from the FoF-11-2016 cluster, through an open and interoperable Data Spine. The federation of the 4 base platforms is complemented by industrial platforms, collaboration tools and smart factory systems, specifically selected to support connected factories in lot-size-one manufacturing. The federated EFPF platform delivers enhances value and reduces the barrier to innovation by providing seamless access to services and solutions that are currently dispersed. In parallel the platform provides the necessary infrastructure, tools and support for novel service creation and validations by third parties. Further, by fostering healthy competition in the smart factory ecosystem, the EFPF platform will ensure that the needs of the evolving smart manufacturing industry are met for the long term. The EFPF federation is offered to the manufacturing and logistic companies as an open platform; to utilise the offered functionality, experiment with innovation approaches and develop custom solutions based on specific needs. The project demonstrates the power of federation through 3 embedded large scale pilots focusing on lot-size-one manufacturing and sustainable value networks in diverse sectors, while a cross sectorial circular economy pilot is also incorporated. The results of the pilots are openly made available as lessons learned and best practices. The creation of the European smart factory ecosystem is supported by offering interested companies technical and financial support. A dedicated budget is allocated to offer financial support to companies who are interested in using the EFPF platform to enhance their businesses. The project is primarily composed of SMEs who have the agility to quickly react and adopt innovative solutions, while experience and market reach of big players such Siemens and others is also leveraged.
Beyond East and West: Developing and Documenting an Evolving Transcultural Musical Practice (Integrating Turkish)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Türkiye,United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2023-07-31
Duration (months): 95.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1834423.0
Participants: 3
Project status: SIGNED

For composers in Turkey today, the urge to integrate the beauties of Turkey’s rich musical heritage into contemporary concert music has become almost an imperative. But differences in tuning, texture, and between oral and notated orientations to performance have presented seemingly intractable obstacles. This project systematises practical processes essential for the creation of a new, East-West strand of contemporary music and opera. It initiates cutting-edge research workshops in Istanbul, Holland and the UK to: 1. Train top-level traditional instrumentalists and singers in Turkey effectively to perform a new repertoire; 2. Train top professional Western singers in non-Western techniques and nuances of vocal production; 3. Develop approaches for modelling such music's impacts on Turkish and Western musicians’ adaptive processes in rehearsal and performance, and diverse audiences’ perceptions of such music; 4. Create an ensemble interface (including newly designed instruments) to increase capacity for merging sounds beyond levels now achievable; 5. Produce groundbreaking studies on timbre to provide new insights into how sound is produced; 6. Establish a new template for mapping Eastern and Western tuning systems onto one another. This research, together with an orchestration manual for Turkish sounds will comprise the core of a published (CUP) team-authored e-book, Integrating Turkish Instruments and Voices into Contemporary Music (ITI), with included audio and visual examples linked as an online resource. Looking further, this project’s multi-modal, transdisciplinary approach also suggests a model for probing how the ‘free play’ of the imagination (Kant) possible within processes of art and its creation can provide metaphors towards understanding one of the most urgent and compelling issues of our time: how to transcend cultural barriers (real or imagined) that exist today.

Keywords: music,workshops,turkish,transcultural,opera,performance,ethnography,ethnomusicology,musicology,music theory,timbre,tuning,interdisciplinary modalities