Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Translating fundamental insights in podocyte metabolism and cell cycle regulation: development of a new treatment for Stopping crescentic Immune Glomerulonephritis (StopIG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a rapid loss of renal function, with severe damage of glomeruli, the filtering units of the kidney through glomerular crescent formation (crescentshaped scars) seen on kidney biopsies. If left untreated, it rapidly progresses into acute renal failure and death within months. Regardless of the underlying cause, RPGN involves severe injury to the kidneys' glomeruli, with many of the glomeruli containing characteristic glomerular crescents. Currently RPGN is treated with broad-spectrum immunosuppression causing remission of the immune injury achieved in the majority of patients. Nevertheless, risk of end- stage renal failure at 5 years is still near 30 %, with a number of patients developing chronic kidney disease (CKD). Moreover, such treatments are associated with significant morbidity due to infections and malignancy. ERC-supported efforts in our lab have unravelled local mediators and transcription factors that critically control the tolerance of intrinsic glomerular cells to inflammatory insult. My team has shown that the PPARγ (peroxisome proliferatoractivated receptors gamma) pathway is instrumental in the protection of the inflammatory response during immunecomplex mediated RPGN, in large part through protection of kidney cells, named podocytes. We now plan to move forward to transform this finding from our TARGET-GLOMDIS ERC grant into a clinically effective innovative therapy. We expect to bring original therapeutic effect by preventing podocytes death and dysfunction in addition to promoting anti-inflammatory actions. The STOPIG project represents a unique opportunity to provide proof-of-concept for a new and cost-effective therapy for patients with RPGN based on stimulation of PPARγ with repurposed pioglitazone.

Keywords: vasculitis,podocyte,drug repurposing,rare disease,therapy,animal model,glomerulonephritis,glomerular disease
Finding how Earthquakes And Storms Impact the Building of Landscapes (FEASIBLe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France,France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2025-11-30
Duration (months): 78.0
Total project cost (EUR): 1498829.0
EU funding (EUR): 1498829.0
Participants: 3
Project status: SIGNED

Unravelling how tectonics, climate and surface processes act and interact to shape the Earth’s surface is one of the most challenging unresolved issue in Earth Sciences. The foundations of modern quantitative geomorphology have been built within the paradigm of steady-state landscapes responding to slow changes in climatic or tectonic conditions, mainly rainfall or uplift rate. Yet, recent results demonstrate that landscapes are rhythmed by (potentially extreme) storms and earthquakes. These perturbations catalyse geomorphological processes by triggering numerous landslides and lead to a prolonged and transient evolution of the landscape that dominate records of modern erosion. The FEASIBLe project therefore calls for a complete re-assessment of the role of short-term climatic and tectonic perturbations in shaping mountain landscapes and for a paradigm shift from steady-state to constantly perturbed landscapes. My ambition is to push forward our understanding of the short- to long-term dynamics of perturbed landscapes and in turn to unlock our ability to read landscapes in terms of earthquake and storm activity. To succeed in this endeavour, the FEASIBLe project will rely on the development of a new generation of landscape evolution model and of novel approaches to intimately monitor landscape heterogeneities and evolution in Taiwan, New-Zealand and Himalayas at high-resolution. The first work packages (WP1-2) will combine field-data analysis and numerical modelling to investigate landslide triggering and the post-perturbation sediment evacuation and landscape dynamics. I will then blend these elementary processes with a statistical description of climatic and tectonic perturbations in a new generation of landscape evolution model (WP3). This new model will be then applied to diagnose the geomorphological signature of fault “seismogenic” rheology (WP4) and to explore the role of post-glacial hot-moments of landscape dynamics on Quaternary landscape evolution (WP5).

Keywords: geomorphology,numerical modelling,extreme events,landslides,river erosion,earthquakes,storms
Innovative Systems to Prevent Ice on Regional Aircraft (InSPIRe)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Austria,Austria,Austria,Austria,United Kingdom
Call: Innovative Low Power De-Icing System (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2022-12-31
Duration (months): 58.0
Total project cost (EUR): 1299340.46
EU funding (EUR): 1299340.0
Participants: 5
Project status: CLOSED

InSPIRe aims at fulfilling all the requirements of the CfP JTI-CS2-2017-CFP06-REG-01-09 “Innovative low power de-icing system” by designing, developing, and manufacturing a demonstrator for a safe, reliable and compact electrothermal low power de-icing system integrated in the wing leading edge for regional aircraft. The proposed technology will be demonstrated in the Icing Wind Tunnel at TRL5 and will be able to meet the goals of Clean Sky 2, WP2.3.1 “Low power WIPS” of the REG IADP. The core of the proposed ice protection system is a proprietary heater layer technology developed by Villinger GmbH, which is an elastic, semi-conductive polymer that can be applied as a thin coating to a variety of parts and components. The key features of the proposed system are: • Low-power electrothermal de-icing capability, offering a 40% power requirement decrease compared to the benchmark electrothermal de-icing protection system; • High system flexibility in terms of allowed configurations and full compatibility with morphing structure; • In-service fault tolerance and maintenance-free architecture; • Wider temperature operating range than the benchmark electrothermal de-icing protection system; The performance of the InSPIRe technology will be achieved due to: • Low thermal inertia of the system, reducing the runback ice formation during unheated periods • Enhanced thermal diffusivity, i.e. lower conductive and convective heat losses • Possibility of removing the parting strip, further reducing the power demand of the system • Advanced control strategy to optimise heater scheduling The InSPIRe system will be designed by a highly experienced consortium relying on state-of-the-art numerical simulation, innovative materials and manufacturing techniques, and thorough testing and qualification activities. The technology will be delivered fully compliant with Civil Certification requirements.

Keywords: ice protection system,regional aircraft,smart leading edge
Wheel Lightweight Manufacturing Process (WELTMAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain
Call: Development and evaluation of a manufacturing process for a lightweight aircraft wheel made of CFRP (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 642750.0
EU funding (EUR): 449925.0
Participants: 2
Project status: CLOSED

The main objective of WELMAP project is the development and evaluation of a manufacturing process for the composite wheel via low-pressure RTM (LP-RTM). The project involves tasks such as manufacturing related advice during the design process of the wheel, development of a manufacturin gprocess, collection of life cycle inventory data of the process, evaluation of fibre lay-up and manufacturing and testing of wheel prototypes.

Keywords: wheel,composite,test,life cycle analysis
Increasing the scope of CO2-utilising photoreactions: asymmetric photosynthesis of amino acids (PHOTOCARBOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Carbon dioxide is released into the atmosphere at an ever-increasing rate due to the burning of fossil fuels. At the same time, the production of bulk and fine chemistry mostly relies on the same crude oil as a carbon source. This situation is unsustainable and therefore calls for the recycling of CO2 as a carbon source. State-of-the-art methods are not sufficient to balance the carbon cycle and therefore it is important to increase the scope of available reactions using CO2. In this proposal, we aim to develop a new methodology using CO2 as a C1-synthon to open up new synthetic pathways. We will bind CO2 to a metal centre and use a radical-coupling pathway to form C-C bonds through an atom-efficient transformation. In this way, we aim to synthesise both natural and unnatural chiral amino acids from amines using visible light and combined photoredox- and CO2-catalysis. The project will contribute to uphold Europe as a world-leader in sustainability by developing novel green methodologies, as well as maintain it as a respected destination for outstanding research by dissemination of the results to both experts and a broader audience. Furthermore, the highly interdisciplinary project and extensive training will prepare the researcher to pursue a successful career in sustainable chemistry.

Keywords: amino acids,carbon dioxide,light,catalysis,photo,valorisation,green chemistry,carboxylic acid,radical coupling
Accelerating user-driven e-infrastructure innovation in Food Agriculture (AGINFRA PLUS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Greece,Bulgaria,Greece,France,Netherlands,Netherlands
Call: User-driven e-infrastructure innovation (H2020-EINFRA-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 2837375.0
EU funding (EUR): 2837375.0
Participants: 8
Project status: CLOSED

AGINFRA+ addresses the challenge of supporting user-driven design and prototyping of innovative e-infrastructure services and applications. It particularly tries to meet the needs of the scientific and technological communities that work on the multi-disciplinary and multi-domain problems related to agriculture and food. It will use, adapt and evolve existing open e-infrastructure resources and services (AGINFRA, OpenAIRE, EGI, EUDAT, D4Science), in order to demonstrate how fast prototyping and development of innovative data- and computing-intensive applications can take place. AGINFRA+ will evolve and develop further the resources and services of the AGINFRA research data e-infrastructure, which has been developed in the context of the FP7 agINFRA project and is now being operated and evolved by key stakeholders in agriculture and food (including Agroknow, the Food and Agriculture Organisation of the United Nations, INRA, Wageningen UR, the Chinese Academy of Agricultural Sciences and others).

Keywords: agri food research e infrastructures
Generation of prototissues from functional and chemoselective protocells (Smart Protocells)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Protocells are micro-compartments able to perform or mimic primitive biological functions of real cells. Because of this, they are proposed as stepping-stones towards the understanding of the origin of life on Earth. These “smart” microcapsules find potential applications in a variety of fields including medicine, pharmacology, energy conversion, and bioengineering. Progress in these fields will be considerably enhanced by gaining control over communication between protocells, as well as engineering collective functions of protocells. An important step towards the achievement of these goals can be made by employing bioorthogonal reactions. Bioorthogonal chemistry is a subclass of click chemistry that includes chemical reactions designed to occur in very complex media like the cell's cytosol. Bioorthogonal reactions are based on exogenous and atoxic reagents that react together quickly, chemoselectively and in quantitative yields. The introduction of bioorthogonal functionalities onto a protocell surface will open new possibilities in protocell engineering. In particular, the creation of bioorthogonally reactive protocells will represent the first step towards the creation of an unprecedented method for artificially controlling protocell communication and the assembly of prototissues with very high spatial and temporal control. The previous expertise of the applicant in the field of bioorthogonal chemistry and chemistry at the interface of materials will be applied to the multidisciplinary and emerging field of protocells in which the hosting group of Professor Stephen Mann FRS at the University of Bristol has been pioneering over the last few years. The key outcome of the combined research efforts of the applicant and the Mann group will lead to the synthesis of bioorthogonally reactive protocells and the investigation of their reactivity for the controlled exchange of biomaterials and the assembly of prototissues.

Keywords: protocell,bioorthogonal chemistry,click chemistry,polymer chemsitry,prototissue,self assembled monolayers
New Recovery Processes to produce Rare Earth -Magnesium Alloys of High Performance and Low Cost (REMAGHIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Spain,Italy,Italy,Germany,Spain,Germany,Italy,Spain,Cyprus,Belgium
Call: Recovery technologies for metals and other minerals (H2020-SPIRE-2015, 2015)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 3709217.5
EU funding (EUR): 3253441.0
Participants: 10
Project status: CLOSED

REMAGHIC is focused on contributing to Europe’s rare earth recovery and magnesium recycling technologies, improving the efficiencies of these processes and advancing the technology readiness levels for a new generation of industrial processes that will produce new low cost competitive alloys for a wide variety of sectors across Europe’s manufacturing value chain. The project motivation lies on the fact that magnesium alloys can offer a significant weight reduction when compared to aluminium alloys. weight reduction is a cross sectorial key design driver, if a superior energy absorption and vibratory behaviour is added, magnesium is promising candidate for future application if some of its drawbacks are overcome, such as its cost, manufacturability problems, corrosion and creep behaviour and low allowable service temperature. Addition of Rare Earth Elements (REE) improves the performance of Mg alloys significantly, though a price increase has to be taken into account. REMAGHIC believes that by investing in recovery and recycling technologies, a new alloying process can be developed to yield low cost Mg+REE alloys. In order to do this, REE that are usually stockpiled (Ce, La) in favour of the most demanded ones (Nd, Dy) will be considered as attractive candidates to lower the price. This list of REE will be completed by other promising candidates found in the literature (Y, Gd, Sa). The project will contribute to reducing the dependency of the supply of critical elements (REE and Mg) on sources exterior to the EU and to solving the REE Balance Problem. REMAGHIC will contribute to the penetration of magnesium alloys in important sectors for the European industry (Transport, Energy, Biomedicine); it will foster the work done by Tier1s, and promote the interest of different OEMs on future generations of light structural components of competitive performance (that of primary Mg+REE alloys), low cost (that of primary Mg) and weight reduction (30%).

Keywords: rare earth elements recovery,mg recycling,mg ree alloys,mg ree recycled alloys,high performance low cost light weight alloys
Matrix Charging: Novel, automated charging infrastructure for electric vehicles (Matrix Charging)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2020-12-31
Duration (months): 26.0
Total project cost (EUR): 2934062.5
EU funding (EUR): 2053843.75
Participants: 1
Project status: CLOSED

Over the next 15 years continuing growth of urbanisation & sprawl will increase the demand for individual mobility & the increase of traffic density will produce many adverse impacts that have direct effects on the quality of life for people living in cities. To lead Europe into a sustainable & competitive future, novel innovations are essential to increase transport efficiency. Vehicle electrification & autonomous driving are two promising new technologies that have disruptive potential for individual mobility whilst giving support “Towards an energy-efficient, decarbonised transport sector”. Sales of Electric Vehicles (EV) tend to be met with high resistance primarily due to range anxiety (max. 100-400 km), variable power costs & long refuelling times (5-8 hours to charge) thus slowing down leadership in electro-mobility. Though these arguments may be valid now, future batteries and charging stations (CS) will reduce these disadvantages. The EV market is projected to grow at a CAGR of 29% & 20 million EVs are going to be on the road by 2022. In 2010, public charging points for EVs were few. Today, there are 112,500 public or semi-public charging points in Europe and is expected to surge at CAGR of 29.8% and reach €10.8Bn global market by 2022.As EV’s become more autonomous there will be greater importance on automated charging. With Matrix Charging® we will have the potential to revolutionize automated EV charging by being the world’s first fully automated conductive charging technology that has no moving parts outside the vehicle. The key innovation is delivering the solution with 99% transmission efficiency, at 30% lower cost than nearest competitor and a 6-fold higher performance with 9% additional efficiency, as we validated with BMW. With a phase 2 cost of €2.9M in early Q2 2018 Matrix Charging® forecasts a €24M gross profit in Yr5 (€44M gross profit Yr1 to Yr5 inclusive period), with a return on investment (ROI) is a very attractive 920% (9.2).

Keywords: electric vehicles,charging stations,automatic charging connectors for electric vehicles
Controlling Cardiomyocyte Dyadic Structure (CARDYADS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Norway
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Contraction and relaxation of cardiac myocytes, and thus the whole heart, are critically dependent on dyads. These functional junctions between t-tubules, which are invaginations of the surface membrane, and the sarcoplasmic reticulum allow efficient control of calcium release into the cytosol, and also its removal. Dyads are formed gradually during development and break down during disease. However, the precise nature of dyadic structure is unclear, even in healthy adult cardiac myocytes, as are the triggers and consequences of altering dyadic integrity. In this proposal, my group will investigate the precise 3-dimensional arrangement of dyads and their proteins during development, adulthood, and heart failure by employing CLEM imaging (PALM and EM tomography). This will be accomplished by developing transgenic mice with fluorescent labels on four dyadic proteins (L-type calcium channel, ryanodine receptor, sodium-calcium exchanger, SERCA), and by imaging tissue from explanted normal and failing human hearts. The signals responsible for controlling dyadic formation, maintenance, and disruption will be determined by performing high-throughput sequencing to identify novel genes involved with these processes in several established model systems. Particular focus will be given to investigating left ventricular wall stress and stretch-dependent gene regulation as controllers of dyadic integrity. Candidate genes will be manipulated in cell models and transgenic animals to promote dyadic formation and maintenance, and reverse dyadic disruption in heart failure. The consequences of dyadic structure for function will be tested experimentally and with mathematical modeling to examine effects on cardiac myocyte calcium homeostasis and whole-heart function. The results of this project are anticipated to yield unprecedented insight into dyadic structure, regulation, and function, and to identify novel therapeutic targets for heart disease patients.

Keywords: cardiac myocyte,calcium homeostasis,excitation contraction coupling,t tubule,dyad,development,heart failure,super resolution microscopy,electron microscopy,signalling