Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards spatially-controlled, bioorthogonal, CuAAC-mediated assembly of targeted oncoprotein degraders (BOOMCHEMBAGS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

I propose an ambitious multidisciplinary strategy to address the challenge of targeting KRAS-mutated cancers through the combination of a novel bioorthogonal strategy to assemble bioactive agents and ‘targeted protein degradation’ (TPD). TPD is an innovative strategy to degrade targeted proteins by hijacking the natural Ubiquitin Proteasome System (UPS) employing heterobifunctional molecules called Proteolysis Targeting Chimeras or PROTACs. These compounds have demonstrated the ability to drive the destruction of well-known harmful proteins. However, their therapeutic implementation has been severely limited by the large size and lipophilicity of these molecules, and by concerns of systemic toxicities. Here, we propose these issues could be circumvented by that the use of PROTACs against KRAS that are assembled from two drug-like fragments via bioorthogonal copper-catalyzed azide alkyne cycloaddition (CuAAC) mediated by Cu nanoparticles (Cu NPs) located in the tumour anatomical area. Furthermore, to avoid the Cu NPs loss of catalytic performance caused by their interaction with the biological milieu, we propose to protect them in sachets made out of a dialysis membrane to avoid biofouling and at the same time, facilitate the entry of precursors of bioactive PROTACs. This highly innovative project has the potential to create far-reaching tools for cancer therapy, and in doing so, promoting European Scientific Excellence. By completing this multidisciplinary work, the applicant will be in an excellence position for create cross-disciplinary collaborations with research groups and industry across Europe and to becoming himself as an independent researcher

Keywords: copper nanoparticles,proteolysis targeting chimeras,kras protein degradation
Zeta functions and Fourier-Mukai transforms (ZETA-FM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2026-08-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Arithmetic geometry and the study of derived categories of coherent sheaves are two central areas of research in algebraic geometry. Despite their many points of contact, they have until recently remained largely disjoint. The zeta function of an algebraic variety over a finite field is one of the most studied invariants in arithmetic geometry, and a conjecture of Orlov predicts that this invariant can be detected by the derived category of coherent sheaves on the variety. In this project, I will prove this for large classes of varieties. To achieve this, I will enrich a wide range of techniques from arithmetic geometry with ideas that have classically been used in the study of derived categories. In this way, this project will also serve as a catalyst for further interaction between arithmetic geometry and derived categories.

Keywords: derived categories,arithmetic geometry,fourier mukai transforms,zeta functions
PHEromones for Row crop Applications (PHERA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Spain,Greece,France,Netherlands,Bangladesh,United Kingdom,Denmark
Call: Demonstrate bio-based pesticides and/or biostimulant agents for sustainable increase in agricultural productivity (H2020-BBI-JTI-2019, 2019)
Start date: 2020-03-01
End date: 2023-08-31
Duration (months): 42.0
Total project cost (EUR): 8510358.01
EU funding (EUR): 6402164.0
Participants: 8
Project status: SIGNED

Agricultural productivity needs to rise by 70% by 2050 to provide sufficient food for the growing population on a limited amount of land and water, while climate change and the onset of insect resistance makes pest control increasingly difficult. The current (overused) tools, chemical insecticides and GMO-crops, are not sustainable and most of the alternative biological solutions are not feasible for the large scale agriculture in row crops due to the high cost, complicated application methods, and inconsistent performance. Mating Disruption (MD) is an effective, affordable, and sustainable pest control method, which uses insect sex pheromones to prevent pest reproduction by disrupting their ability to attract mating partners. Mating Disruption is a scalable new solution for row crops, with 20-years of successful application in specialty crops. MD is a sustainable, non-toxic pest control method, which does not affect biodiversity, soil, or groundwater. The key objectives of PHERA are to demonstrate cost-efficient production of three bio-based pheromones at full industrial scale and to demonstrate pheromone effectiveness for pest control and for sustainable increase of agricultural productivity in the field. The cost of pheromones has been a key barrier to the wide adoption of MD in row crops. Biological production of radically cheaper pheromones is a disruptive technology that will allow the application of pheromones for pest control in row crops. PHERA will create a new value chain across biotech and ag-tech, and the consortium brings together all required expertise in biotech production and pheromone formulation and application. PHERA will create a new ag-tech business for MD solutions in row crop applications worth €640 million and 300 new jobs by 2027, and a long-term potential in excess of €2 billion. The new products developed in PHERA will have a substantial positive impact on the sustainability profile of large-scale row crop production.

Keywords: insect sex pheromones,mating disruption,ipm for row crops,fermentation
Autonomous cranes based on computer vision and AI to increase productivity and safety on construction sites (AUTOSITE100)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

INTSITE is an Israeli company founded in 2017 with the mission of increasing efficiency, profitability and safety in construction. Our objective is to develop Artificial Intelligence based systems for autonomous construction machinery. Over the last 2 years, we have developed AUTOSITE100 -Autonomous Crane System- that converts any crane into an autonomous machine and provides the management team with real-time site insight for improved decision making. Cranes are the main bottleneck of any construction site: despite hoisting 70 % of all materials and equipment, their efficiency is only 55%-65%. In addition, cranes are one of the largest sources of fatal accidents in construction projects (3,480 crane fatal accidents in the EU in 2017 caused by human error). Incorporating AUTOSITE100 into any crane will provide improved efficiency (30% productivity increase, 24/7 operation), increased safety (real-time detection of every fixed and moving object in the site) and smarter overall site management (real-time map updated and crane activity dashboard). AUTOSITE100 is a patented technology that combines Computer Vision, Artificial Intelligence (Deep Learning), Machine Learning techniques and aerospace algorithms with off-the-shelf hardware. Existing solutions in the market are far behind AUTOSITE100 and only work on improving either safety or efficiency, but none of them offers both in a single product, as we do. AUTOSITE100 goes beyond current solutions by using machine vision technology (Artificial Intelligence and Computer Vision). It transforms current cranes into high-efficiency autonomous cranes, providing decision-making tools for the management team and avoiding collisions.

Keywords: cranes,tower buildings,autonomous machine,safety,efficiency,site management
Trafficking of girls and Catholic missionary networks in the South China Sea (18th-19th centuries): a transnational approach (UNSILENCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: SIGNED

Child trafficking is one of the most challenging problems of our time, a problem with deep historical roots. This interdisciplinary project aims to contribute to the understanding of these roots by studying the migration of abandoned children organised by members of Catholic religious orders in the South China Sea during the 18th and 19th centuries. As part of the Catholic mission in China, Jesuits, Dominicans, and Franciscans took in and bought abandoned Chinese children in their inland missions, Canton and Macau, whence many of these children were sent to distant places such as the Philippines or Goa to be raised as Christians. The project will first reconstruct the channels through which these children, mostly girls, were transported, using Portuguese, Spanish and Chinese sources; and, second, analyse the ethical and moral boundaries crossed and the various effects of this phenomenon in the European and Catholic projects of the Early Modern period. At the same time, it will UNSILENCE the voice of these historiographically neglected children. How many girls were involved in this flow? What was their fate and life trajectories in their foster societies? What was their agency? Unveiling this hitherto unknown traffic and examining its consequences will open a new chapter in the history of early modern intra-Pacific circulations and the analysis of intercultural encounters. Fully within the framework of KU Leuven’s strategic goals, the researcher's cooperation with the ERC AdG TRANSPACIFIC project, and the dissemination of results (high-impact publications, an international conference and a ground-breaking exhibition with educational materials) will greatly boost her career. Moreover, this innovative project will raise awareness about the importance of history in tackling current European and international challenges such as gender equality, decolonisation, and the protection of human rights.

Keywords: early modern iberian empires,human trafficking,childhood,christianity in china,eurasian encounters,women identity in early modern history
Beyond EPICA - Oldest Ice (BE-OI)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Coordination and support actions
Countries involved: Italy,Italy,Germany,Switzerland,Belgium,Sweden,Sweden,Norway,France,France,Netherlands,Denmark,United Kingdom,United Kingdom
Call: A 1.5 million year look into the past for improving climate predictions (H2020-SC5-2016-OneStageB, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 2594000.0
EU funding (EUR): 2223000.0
Participants: 15
Project status: CLOSED

To better constrain the response of Earth’s climate system to continuing emissions, it is essential to turn to the past. A key advance would be to understand the transition in Earth’s climate response to changes in orbital forcing during the 'mid-Pleistocene transition' (900 to 1200 thousand years ago) and in particular the role of greenhouse gases. Unravelling such key linkages between the carbon cycle, ice sheets, atmosphere and ocean behaviour is vital for society to better design effective mitigation and adaptation strategies. Only ice cores contain the unique and quantitative information about past climate forcing and atmospheric responses. But the ice providing essential evidence about past mechanisms of climate change more than 1 Ma ago required for our understanding of these changes (termed the “Oldest Ice” core), has not been found to date. The consortium BEYOND EPICA – OLDEST ICE (BE-OI), formed by 14 European institutions, takes on this challenge to prepare the ground for obtaining 1.5 million year old ice from East Antarctica. BE-OI has the objectives to: - support the site selection through creation and synthesis of all necessary information on Antarctic sites through specific geophysical surveys and the use of fast drilling tools to qualify sites and validate the age of their ice; - select and evaluate the optimum drill site for the future “Oldest Ice” core project and establish a science and management plan for a future drilling; - coordinate the technical and scientific planning to ensure the availability of the technical means to implement suitable drill systems and analytical methodologies for a future ice-core drilling, and of well-trained personnel to operate them successfully; - establish the budget and the financial background for a future deep-drilling campaign; - embed the scientific aims of an “Oldest Ice” core project within the wider paleoclimate data and modelling communities through international and cross-disciplinary cooperation.

Keywords: ice core,oldest ice,ipics,antarctica
Spatial fractionation of the dose in proton therapy: a novel therapeutic approach (PROTONMBRT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-10-01
End date: 2025-09-30
Duration (months): 72.0
Total project cost (EUR): 1997870.0
EU funding (EUR): 1997870.0
Participants: 1
Project status: SIGNED

Radiotherapy (RT) is one of the most frequently used methods for cancer treatment (above 50% of patients will receive RT). Despite remarkable advancements, the dose tolerances of normal tissues continue to be the main limitation in RT. Finding novel approaches that allow increasing normal tissue resistance is of utmost importance. This would make it possible to escalate tumour dose, resulting in an improvement in cure rate. With this aim, I propose a new approach, called proton minibeam radiation therapy (PROTONMBRT), which combines the prominent advantages of protons for RT and the remarkable tissue preservation provided by the use of submillimetric field sizes and a spatial fractionation of the dose, as in minibeam radiation therapy (MBRT). The main objectives of this project are to explore the gain of therapeutic index for radioresistant tumors, to disentangle the biological mechanisms involved and to evaluate the clinical potential of this novel approach. For this purpose, a method for minibeam generation adequate for patient treatments and a complete set of dosimetric tools will be developed. Then, tumour control effectiveness will be evaluated, and the possible biological mechanisms involved both in tumour and normal tissue responses will be disentangled. The gain in normal tissue recovery can foster one of the main applications of proton therapy, paediatric oncology, as well as open the door to an effective treatment of very radioresistant tumours, such as high-grade gliomas, which are currently mostly treated palliatively.

Keywords: medical physics,dosimetry,radiobiology,normal tissue toxicity
Ecological Language: A multimodal approach to language and the brain (ECOLANG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2024-06-30
Duration (months): 78.0
Total project cost (EUR): 2243584.0
EU funding (EUR): 2221020.0
Participants: 3
Project status: SIGNED

The human brain has evolved the ability to support communication in complex and dynamic environments. In such environments, language is learned, and mostly used in face-to-face contexts in which processing and learning is based on multiple cues: linguistic (such as lexical, syntactic), but also discourse, prosody, face and hands (gestures). Yet, our understanding of how language is learnt and processed, and its associated neural circuitry, comes almost exclusively from reductionist approaches in which the multimodal signal is reduced to speech or text. ECOLANG will pioneer a new way to study language comprehension and learning using a real-world approach in which language is analysed in its rich face-to-face multimodal environment (i.e., language’s ecological niche). Experimental rigour is not compromised by the use of innovative technologies (combining automatic, manual and crowdsourcing methods for annotation; creating avatar stimuli for our experiments) and state-of-the-art modelling and data analysis (probabilistic modelling and network-based analyses). ECOLANG studies how the different cues available in face-to-face communication dynamically contribute to processing and learning in adults, children and aphasic patients in contexts representative of everyday conversation. We collect and annotate a corpus of naturalistic language which is then used to derive quantitative informativeness measures for each cue and their combination using computational models, tested and refined on the basis of behavioural and neuroscientific data. We use converging methodologies (behavioural, EEG, fMRI and lesion-symptom mapping) and we investigate different populations (3-4 years old children, healthy and aphasic adults) in order to develop mechanistic accounts of multimodal communication at the cognitive as well as neural level that can explain processing and learning (by both children and adults) and can have impact on the rehabilitation of language functions after stroke.

Keywords: neurobiology of language,gestures,face to face communication
Fly with Big Data (MyKite)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nowadays, everyone has access to big data, but just a few are able to collect, store, elaborate and interpret them. Indeed, "you almost have to get a complete education in analytics to choose your first monitoring package. A lot of organisations want to get into the game and make themselves competitive with the big boys. But the learning curve is horrendous", Scott Robinson, SharePoint and BI expert, stated. MyKite aim to shorten the distance between media big data (social media and web) analytics and SMEs as well as unskilled people, so reducing the probability to face unequal access to big data with big companies leading the market and non-specialised audience falling behind. It offers the possibility to gain insights on sector observatories through a user-friendly dashboard, with easy-to-read widgets and engaging videos, visually summarising the main findings as a story. Moreover, people may have whatever sector insights and whenever they want for a very competitive monthly fee. Finally, the product can potentially create a new stream of services of market trends video-storytelling approachable by anyone. So, to go ahead of competition, we need to speed-up our development and commercialisation. Through this Phase 1 we want to explore different commercialisation and IP protection strategies and identify key partners for a consortium. At Phase 2, we aim to successfully bring MyKite to the market by integrating the predictive and visual analytics algorithms and the video storytelling feature. We estimate a duration of 24 months and a funding requirement of ca. 850k EUR to reach a revenue of €16M in 2022. Based on our market studies, we will initially focus on the Italian, European and North American markets, demonstrating a higher readiness to pay. The capability and vision of the heterogeneous team to adapt to the new market challenges and to understand SMEs needs, and its knowledge in social media and web analytics are key features for the product success.

Keywords: social media,analytics,gaming