Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Space-Time scAling of the Rainfall to FLOOD transformation (STARFLOOD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

Floods are among the costliest of all natural hazards. The June 2013 flood in Central Europe, for example, incurred more than EUR 12 billion of economic losses, and flood risks are expected to increase significantly in the future. Reliable approaches for estimating flood probabilities in space and time are needed for optimising flood risk management. For almost a century, the standard method of flood estimation has been the purely statistical “flood frequency analysis”. The method does not account for the spatio-temporal behaviour of floods which, however, is essential for trans-regional flood planning as stipulated in the EU Flood Directive (2007/60/EC). Also, flooding is a physical process in space and time, so future flood risk assessment requires a better understanding of the physical basis behind the space-time characteristics of flood probabilities. These have been explored only by a few studies, e.g. by coupling weather models with runoff models, but only at small spatial scales and ignoring the space-time characteristics of the weather fields, hydrological processes and flood peaks. My project “Space-Time scAling of the Rainfall to FLOOD transformation” (STARFLOOD) responds to this research gap by investigating, for the first time, how the probabilities of rainfall transform into probabilities of floods from a space-time perspective, and how they can be simulated by space-time stochastic weather models at large spatial scales. STARFLOOD is highly innovative as it (i) explores the performance of the full cascade of rainfall to flood probabilities, (ii) explores the physical causes of flood probabilities and (iii) significantly improves the understanding of the scaling behaviour of hydrological processes. STARFLOOD will become a pioneering framework for the improved implementation of the EU Flood Directive and thus significantly advance future trans-regional flood risk management across Europe.

Keywords: hydrology,flood modelling,flood hazard,rainfall,scaling behaviour,weather generation
ADVanced Inspection of Complex StructurEs (ADVISE)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Lithuania,Hungary,France,France,France,Czechia,United Kingdom,United Kingdom
Call: Continually improving safety and reliability of Generation II and III reactors (NFRP-2016-2017-1, 2016)
Start date: 2017-09-01
End date: 2022-02-28
Duration (months): 54.0
Total project cost (EUR): 4546407.5
EU funding (EUR): 4168855.0
Participants: 14
Project status: CLOSED

ADVISE aims to advance the ultrasonic inspection of complex structured materials, for which conventional ultrasonic techniques suffer from severe performance limitations due to the micro and/or macro-structure. The project relies on a multi-pronged strategy: - Model-assisted inspection enhancement tools allow the iterative optimisation of customised transducers and associated excitation signals, to specify the most appropriate inspection approach. - Novel in-situ characterisation techniques acquire specific information about the structure to be inspected; then model-assisted optimisation tools fine-tune the inspection parameters in the field. - Model-assisted diagnostic tools take a-priori, model-predicted and in-situ obtained information into account to fully exploit the information contained in full matrix capture (FMC) acquisitions, using adaptive imaging methods, backscatter filtering and inversion strategies. The main output of the project is thus a step change improvement in performance in terms of inspectable depth, defect detection and characterisation accuracy. For austeno-ferritic cast components, an increase of the inspectable depth of 70 to 85 mm is aimed for. Equally importantly, the in-situ characterisation for specific inspections will provide the confidence needed to make safe decisions from measured indications without the significant conservatism that is needed in many cases currently. ADVISE brings together leading experts and key stakeholders with long-term commitments to this subject, covering construction, operation, and all aspects of in-service inspection. They will collaborate for new nuclear power constructions, maintenance of ageing power stations and safe operation of plants at end of life, addressing both Western European and Russian designs. An Industrial Advisory Board will play a major role throughout the project to guarantee a focus on the key issues and thereby ensure rapid deployment of the ADVISE developed techniques and tools.

Keywords: non destructive evaluation,non destructive testing,ultrasonic inspection,material characterisation,phased array transducer,weld inspection
REinforcing Women In REsearch (REWIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Austria
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 3530880.0
EU funding (EUR): 1765440.0
Participants: 1
Project status: SIGNED

The overall goal of the REinforcing Women In REsearch (REWIRE) COFUND Programme is to establish a support scheme for excellent postdoctoral female researchers to foster their scientific development, to nurture their expertise and to make a profound impact on their future careers. We are aiming to create a sustainable support structure where the most talented, qualified researchers want to be. Through its own success, REWIRE is expected to influence the general recruitment practices at the University of Vienna and have further impact at regional, national and international levels. The highly competitive nature of this fellowship programme should also give the fellows the confidence to continue in their academic careers and become role models for future female talents. With a customised career development plan, the fellow will be encouraged to: participate in non-research oriented training programmes; develop transferable skills; be part of and build upon an enhanced research network; and enjoy international exposure through publications in high-profile journals and participation in conferences. This five year Programme will offer 16 fellowships of 36 months in any discipline hosted by the University of Vienna. In turn, the University offers excellent research facilities, additional training in areas of importance to the development of the fellow, an enhanced research network and international exposure.

Keywords: postdoctoral training,women in academia,fellowships,career development
Effects of global change on the emission, fate, effects and risks of chemicals in aquatic ecosystems (ECORISK2050)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Israel,Spain,Sweden,Norway,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-10-10
End date: 2023-04-09
Duration (months): 54.0
Total project cost (EUR): 3596088.24
EU funding (EUR): 3596088.24
Participants: 8
Project status: SIGNED

By 2050, the world population will reach nine billion people and three quarters of the global population will live in cities. The development path to 2050 will be marked by shifts in land-use and weather patterns, and by changes in the way water and food resources are obtained and managed all over the world. These global changes (GCs) will affect the emissions, environmental transport pathways and fate of chemicals, and thus affect the exposure of the natural environment to chemicals. Future changes may also alter the sensitivity of ecosystems to chemical exposure. Therefore, the ECORISK2050 project brings together a world leading and interdisciplinary consortium of universities, research institutes, industry and regulatory and governmental authorities to deliver a cohort of Early Stage Researchers (ESRs). The coupled training goals and research objectives of the project are: (1) to assess how the inputs of chemicals from agriculture and urban environments and their fate and transport are affected by different environmental conditions, including those of specific EU regions, and how this will change under GC scenarios in order to assess the likely increase in chemical risks to human and ecosystem health; (2) to identify potential adaptation and mitigation strategies that can be implemented in the short and medium term, to abate unacceptable changes in risks, and use the GC scenarios to propose robust implementation pathways, and (3) to develop a set of tools for use by industry and policy makers, that allow the impacts of a range of GC-related drivers on chemicals risks to be assessed and managed. The project will deliver the next generation of scientists, consultants and industry and governmental decision-makers who have the knowledge and skill sets required to address the changing pressures that chemicals emitted by agricultural and urban activities pose to aquatic systems on the path to 2050 and beyond.

Keywords: global change,pesticides,pharmaceuticals,personal and home care products,industial chemicals,climate change,urbanisation,scenarios,exposure,effects,risks and mitigation
Advanced Biomass Catalytic Conversion to Middle Distillates in Molten Salts (ABC-SALT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Norway,Belgium,Sweden,Sweden,France,France,Netherlands,Netherlands,United Kingdom
Call: New knowledge and technologies (H2020-LCE-2017-RES-RIA-TwoStage, 2017)
Start date: 2018-04-01
End date: 2022-09-30
Duration (months): 54.0
Total project cost (EUR): 3998025.5
EU funding (EUR): 3998025.5
Participants: 13
Project status: SIGNED

ABC-SALT will validate at lab scale a novel route to produce sustainable liquid biofuels (middle distillates (MD)) from various lignocellulosic waste streams for the transport industry, both on roads (biodiesel) and in air (jet fuel), targeting a yield over 35 wt% in the middle distillate range, based on the biomass dry input, and a carbon yield of 55 %. ABC-SALT will solve the following technical challenges: liquefaction and subsequent catalytic hydro-pyrolysis of the biomass in a molten salt environment, followed by the catalytic hydro-deoxygenation of the vapour phase using suitable catalysts to obtain a hydrocarbon product suitable for use as a MD biofuel. ABC-SALT will then operate an integrated lab scale reactor during over 100 hours to provide lab-scale validation of the whole process, bringing this technology to TRL 4. The project includes technical aspects (such as substrate flexibility, biomass liquefaction and hydro-pyrolysis in molten salts and subsequent hydro-deoxygenation and their integration), but also a socio- and techno-economic viability study of the technology (substrate availability and supply chain, future end-users and economic sustainability of the process). This will ensure the future deployment of this new technology considering its social related issues, such as acceptance or modification of the perception of transport induced by such sustainable fuels. Such a holistic approach considering the full value chain, combined to communication with stakeholders during the course of the project, will provide valuable input for scale up and industry-oriented research after this project, maximizing the impact, amongst other in the biomass, biofuel and transport industry. To reach its objectives, the project covers the whole value chain, from feedstock supplier to end-users (knowledge users (RUG, UG, AU, NMBU, DLR), technology users (BTG, Innventia), and middle distillates users (through DLR)), as well as an entity dedicated to SSH aspects (CIRPA).

Keywords: middle distillate,biofuels,lignocellulosic waste,molten salts,hydropyrolysis,hydrodeoxygenation,trl4,techno economic assessment,ecological evaluation,biomass to liquid,social impact
Social Cognition in Adolescents: Brain Networks and Social Networks (SCANS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-02-01
End date: 2022-01-31
Duration (months): 72.0
Total project cost (EUR): 1998655.0
EU funding (EUR): 1998655.0
Participants: 1
Project status: CLOSED

The forming of social bonds is an evolutionary imperative, and a rich target for empirical research. Social scientists have scrutinized the structure of the elaborate social networks that characterize today’s society. Neuroscientists have elucidated the brain mechanisms underlying our ability to navigate this social world. Yet, these research lines have been largely separated. This proposal aims to integrate social network research and social brain research, focusing on adolescence as the most dynamic phase shaping the interplay between social networks and the social brain. Social development in adolescents is clearly driven by maturation of specific social-cognitive functions; yet these functions are manifest in, and moulded by, interpersonal relationships within social networks. I aim to clarify how changes in the social brain relate to changes in social network position and structure during adolescent development. This can be achieved by using the quantitative tools of social network analysis in conjunction with the experimental approach of social neuroscience. I plan to investigate a cohort of approximately 1000 adolescents nested in 50 classes in a longitudinal design with 6 measurements over 3 years; fMRI investigating task-related functional activation and connectivity is conducted yearly in a subsample of 100. The neural and behavioural correlates of social cognition are investigated using experimental tasks tapping i) understanding others and ii) interacting with others; social behaviour is charted through ecological momentary assessment techniques; social networks are mapped using surveys and digital information acquired routinely via mobile phones (mobile sensing). This approach clarifies how during a crucial developmental phase the social brain shapes the social environment, and vice versa, the social environment influences maturation of the social brain.

Keywords: social cognition,functional neuroimaging,social network analysis
Holistic Quantum Mechanics Based Platform to Accelerate Drug Discovery (PharmScreen2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 1369575.0
EU funding (EUR): 958702.5
Participants: 1
Project status: SIGNED

Drug discovery & development projects are long processes that take approximately 15 years from the moment a molecular target is discovered to its market launch. During the past two decades, the costs of new drug development has increased from €1 billion in 2000 to €2.58 billion in 2015. The increase is due in part to the difficulty to find New Molecular Entities (NME) subject to be patented. Computer-aided drug design (CADD) tools are used to perform virtual screening, design and the optimization of candidate molecules, but they focus in single aspects of the molecule (e.g. activity or toxicity) giving a narrow view at each development stage of the early drug discovery process, translating into expensive design cycles. The chemical space is very large and simple therapeutic areas have already been explored, therefore, the quality of the data obtained with CADD solutions is low. Only 4% of NMEs will successfully make it from the initial discovery phase to launch. To solve this problem, Pharamacelera has developed PharmScreen2, a unique and propiesoftware for drug discovery using novel molecular descriptors that enables accurate predictions of molecular properties of candidate molecules, which thereby increases the success rate of leads identification by 3x and will reduce the overall costs of drug design & development processes by 25%. PharmScreen2 is the only software that integrates the capability of performing advanced simulations of all the properties that are key in later drug discovery stages, such as activity, absorption, distribution, metabolism, toxicity (ADME-Tox) giving a holistic view. PharmScreen2 can analyse behaviors of new candidate molecules, predict the compounds’ performance in later stages and identify undesired effects early. The main objective of this project is to finalise the development of PharmScreen2, PoC with industrial partners and prepare the new PharmScreen2 from market. Pharmacelera estimates a total market size of 5.3 billion by 2023.

Keywords: drug development,adme tox prediction,advanced mollecular modelling,quantum computing,predictive models,one shot learning
Micro Quantum Dot-Light Emitting Diode and Organic Light Emitting Diode Direct Patterning (MILEDI) (MiLEDI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Italy,Germany,Italy,Israel,Italy,Lithuania,France,France,United Kingdom
Call: Photonics KET 2017 (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 4130041.25
EU funding (EUR): 4130041.25
Participants: 10
Project status: CLOSED

The project MiLEDI aims to realise micro-Light Emitting Diodes (mQDL) and micro -Organic Light Emitting Diodes (mQDO) using direct laser or electron beam patterning of nanometer-scale Quantum Dots (QDs) to write the Red-Green-Blue (RGB) arrays for display manufacturing. The main idea sustaining the project is to form the colored green-red light-emitting QDs directly over a matrix of blue emitting micro QDL/QDO arrays, so that the QDs act as frequency down-converters and constitute a RGB micro-display. Both direct-writing technologies will be thoroughly developed to optimize the QD light emission spectrum of the display and its stability. They are expected to provide patterning resolution at micrometric scales, depending on the laser spot areas and particle beam dimensions and operation. These techniques together with the direct formation of QDs assure highly flexible and simpler manufacturing processes, in few steps and with low chemical impact The MiLEDI approach for both micro QDL and QDO RGB displays manufactured by direct laser/electron beam patterning of QDs, is validated by the production of a final prototype of Rear Projection display through the existing supply chain of the project.

Keywords: quantum dots,laser patterning,electron beam patterning,oled
Sweden EEN consortium Innovation Support 2020-2021 (Swennis 2020-2021)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Sweden,Sweden,Sweden,Sweden,Sweden,Sweden,Sweden,Sweden,Sweden,Sweden
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 871523.75
EU funding (EUR): 871523.75
Participants: 13
Project status: CLOSED

Successful growth companies tend to be significantly better at innovation management than average. However, most SMEs and SME support organisations consider the inability to manage innovation processes efficiently and effectively as one of the most important barriers to create European economic impact (competitiveness, growth and jobs) from innovation activities in SMEs. The objective of this project proposal is to address these problems by providing services enhancing the innovation management capacity of SMEs wishing to develop innovation projects with a strong European or international potential. All three partners active in this proposal are partners in Enterprise Europe Network under COSME (SweNet) to assure fully integrated services and a true one-stop-shop for business and innovation support to SMEs. Consequently, synergies with COSME activities are easily identified. All innovation experts will also have a role as both KAM and EIMC providers and synergies will be handled effectively. Each client specific needs will be prioritised during the client journey ensuring that we will make the best use of our resources, including the local, national and EU ecosystem.

Keywords: sme instrument,eimc services,innovation health check,idd4sme
A novel in vivo platform to study and target undruggable Ewing onco-chimera. (EwiSarc)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Development of efficient therapeutic strategies in the past years has drastically reduced the lethality of several common types of pediatric and juvenile form of cancer such as leukemia, lymphoma and brain tumors. Such a tremendous success, however, does not include sarcomas treatment, whose mortality rate remains the same as twenty years ago. Ewing sarcoma is a childhood cancer with a relatively low incidence, with 3 cases/million/year. The initial oncogenic event is represented by a balanced chromosomal translocation originating a transcription factor chimeric onco-protein. Notably, 90% of Ewing sarcoma patients are characterized by the fusion between EWS and FLI1 genes. From a therapeutic point of view, as exclusive hallmark of tumor cells and driving force of the disease, the onco-chimera protein represents an ideal target, even though transcription factor onco-proteins are classified as “undruggable” from a conventional pharmacological point of view, lacking in their structure convenient targeting pockets. This project aims to break this dogma through the following steps: 1. Generation of an in vivo genetic platform based on an innovative ex vivo-in vitro-in vivo approach that will allow us to accurately recapitulate in mice Ewing sarcomagenesis; 2. Characterization in vivo and in vitro of those mechanisms and pathways that are essential for the tumorigenic process; and finally, 3. Identification of druggable targets whose fine-tuning will tear down Ewing sarcoma lethality by promoting onco-chimera degradation. The success of this project will not only lead to the development of new therapies against Ewing sarcoma, but also to the development of a novel platform which will be easily exported to other tumors driven by “undruggable” onco-chimeras.

Keywords: mouse modeling,stem cells,ewing sarcoma,therapy