Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Creating complexity: toward atomic spin-based neural hardware (SPINAPSE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 2357390.0
EU funding (EUR): 2357390.0
Participants: 1
Project status: SIGNED

The growing trend in global electricity consumption has created a new challenge for materials-based science: to find computational paradigms toward ICT that are not only smaller and faster, but also energy-efficient. A new source of inspiration is the human brain, which consumes a mere 20 W of energy, while a supercomputer consumes about 10 MW. The emerging field of brain-inspired hardware aims at utilizing physical phenomena in high-quality materials toward pattern recognition and energy- efficient ICT. The goal of this project is to adapt the principles of magnetism toward brain-inspired hardware, utilizing individual and coupled atomic spins. The ultimate aim of SPINAPSE is to probe the feasibility and create proof-of-concept systems, which demonstrate computational principles such as pattern recognition. I define three objectives, which address understanding magnetism in the three most prominent neural models: (1) Hopfield model, (2) Perceptron, (3) Reservoir computing. The strategy is to utilize the so-called spin workbench, based on low-temperature scanning tunneling microscopy, as a platform to create tailored spin arrays with atomic-scale control. This method combines single atom magnetic imaging and atom-scale fabrication, enabling the control of the magnetic interactions and dynamics between ensembles of atoms, atom by atom. We will construct bottom-up magnetic nanostructures to implement all-spin and atomic-scale based neural hardware. We will deliver a new state of the art in magnetic imaging, including (a) developing the spin workbench with a newly built 30 mK magnetic STM facility, defining a new state of the art in magnetic imaging worldwide, and (b) time-resolved imaging to probe the magnetization dynamics of stochastic spin arrays at milliKelvin temperatures. The outcome of SPINAPSE will deliver a new state of the art, new fundamental understandings, and create proof-of-concept technologies for atomic-scale brain-inspired hardware.
anti-pseudoMOnas aeruginosa biofilm NAno-in-hydroGEL (MONAGEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Pseudomonas aeruginosa (PA) is ubiquitous gram-negative bacteria. PA is a serious threat and is considered as a critical priority for treatment development by various institutions such as the World Health Organization. PA can cause infections on various location such as eyes, lung, skin (wounds). Immunocompromised patients are especially at risk, as PA is also able to colonize domestic and hospital fixtures. To add insult to injury, the infection is hard to treat and the number of antibiotic resistant PA is on the rise. The major challenge opposed by PA is its biofilm. Biofilms are a structured bacterial community embedded in a matrix composed of exopolysaccharides, proteins, extracellular DNA, and lipids. PA present in the biofilm are a thousand times less sensitive to antibiotics than their planktonic form. The MONAGEL project propose to fight the PA in the biofilm by developing a hydrogel made of cross-linked lipid nanoparticles. The lipophilic core of the lipid nanoparticles will be used to encapsulate hydrophobic active ingredients, the aqueous cavities of the gel will be used to encapsulate hydrophilic ones. The hydrophobic and hydrophilic compartment will enable work with a broad variety of molecules such as fluorescent probes (which will permit a thorough characterisation of the gel) or active ingredients such as antibiotics and pathoblockers. The latter molecule will be efficient to design the gel towards fighting PA biofilm either by inhibiting quorum sensing (bacterial communication) or lectin interaction (key role in biofilm formation). Well thought work and contingency plans have been put in place to ensure the success of MONAGEL development. The innocuity of the system will be assessed on various cell lines, and the antibiofilm efficacy will be tested on in vitro models. In the end, the MONAGEL efficacy will be demonstrated on a co-culture model (epithelium + biofilm) as a proof-of-concept to serve as a selling point for further development.

Keywords: hydrogel,nanomedicine
Center of Excellence for Global Systems Science (COEGSS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Spain,Germany,Germany,Sweden,Poland,France
Call: Centres of Excellence for computing applications (H2020-EINFRA-2015-1, 2015)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 4469662.5
EU funding (EUR): 4469662.5
Participants: 13
Project status: CLOSED

Global Systems Science – GSS – is an emerging research field focused on the risks and opportunities involved in global coordination problems. Examples of global systems include the internet, financial markets, intellectual property rights, global energy use and others. Developing evidence and understanding in view of such systems and of related policies is rapidly becoming a vital challenge for modern societies. It requires capabilities for transdisciplinary work that cannot be mastered without massive use of ICT. By the nature of the problem, the relevant datasets are mostly very big, including data streams from social medi. To make things more complicated, the relevant algorithms do require the power of high-performance computing. High Performance Data Analysis (HPDA) is the key to success for GSS! A key contribution of the Center of Excellence for Global Systems Science – COEGSS – will be the development of an HPC-based framework to generate customized synthetic populations for GSS applications. By blending GSS and HPC, we will be able to provide decision makers and civil society with real-time assessments of global risks and opportunities as well as with essential background knowledge about them. This will enable the HPC industry to supply hard- and software for applications well beyond the issues to which HPC has been dedicated so far.

Keywords: high performance computing,big data,social media
High-Performance Real-time Architectures for Low-Power Embedded Systems (HERCULES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Switzerland,Czechia
Call: Customised and low power computing (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 3261443.47
EU funding (EUR): 2072300.0
Participants: 7
Project status: CLOSED

The advent of commercial-of-the-shelf (COTS) heterogeneous multi-core platforms is opening up a series of opportunities in the embedded computing market. Integrating multiple computing element running at smaller frequencies allows obtaining impressive performance capabilities at a reduced power consumption. At the same time, new applications are being proposed integrating more and more functionalities in the objects commonly used for our daily activities, imposing a number of additional requirements to embedded systems designers: - higher computing workloads, elaborating and fusing multiple sensor data; - reduced power consumption, allowing smaller batteries and renewable power sources; - quicker interaction with the environment, requiring a prompt elaboration of sensor data; - higher criticality, replacing safety-critical human activities. These converging needs call for “real-time embedded super-computing platforms” that are able to predictably provide real-time guarantees to applications running on top of next generation embedded platforms. These applications do not only require high performance at low power. They also need to provide predictable guarantees. Having impressive average performances with no guaranteed bounds on the response times of the critical computing activities is of little if no use to these applications. Project HERCULES will provide the required technological infrastructure to obtain an order-of-magnitude improvement in the cost and power consumption of next generation real-time applications. It will develop an integrated framework to allow achieving predictable performance on top of cutting-edge heterogeneous CTOS multi-core platforms, implementing real-time scheduling techniques and execution models recently proposed in the research community. The framework will be applied to two innovative industrial use cases: a pioneering autonomous driving system for the automotive domain, and a visual recognition system for the avionic domain.

Keywords: real time systems,power aware embedded computing,heterogeneous platforms
Epigenetic biomarkers for prediction of vascular complications and response to treatment in subjects with diabetes (EpiHope)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Type 2 diabetes (T2D) is one of the leading causes of death through its deleterious effects on cardiovascular disease (CVD). The complications of T2D can be reduced through early and appropriate preventive and therapeutic interventions. Several studies suggest that epigenetics may play a key role in the pathogenesis of these diseases. However, additional studies are needed to improve primary prevention and treatment of T2D and vascular complications. Our overall objective is to identify novel epigenetic biomarkers of clinical relevance that predict, monitor progression and forecast response to treatment of T2D and CVD. First we aim to identify clinically useful epigenetic biomarkers (DNA methylation will be analysed genome-wide) that can predict the glycaemic response to metformin treatment and future risk of CVD in newly diagnosed T2D patients recruited from ANDIS cohort. Second, the most efficient epigenetic biomarkers identified will be validated in T2D patients from ANDIS using pyrosequencing. Third, we aim to make combined predictive risk scores with our novel epigenetic biomarkers, genetic and clinical risk factors to assess risk for CVD. Finally, we will test functional characterization of the validated epigenetic biomarkers in target tissues from T2D patients, and in vitro follow-up studies will be developed. This project represents an outstanding opportunity for personalized treatment for T2D, proposing for the first time pharmacoepigenetics in this field, and also for the development of a panel of high-quality epigenetic biomarkers together with combined risk scores, aiming to give a new reliable clinical tool for early prevention of CVD in T2D patients. Notably, epigenetic modifications can be manipulated more readily than genomic mutations, and thereby has much of potential for pharmacological applications. In summary, the findings of robust epigenetic biomarkers will optimize the therapeutics of T2D and the preventive care of vascular complications.

Keywords: epigenetics,type 2 diabetes,vascular complications,biomarker,early prevention
Reducing the Burden of Smouldering Megafires: an Earth-Scale Challenge (HAZE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1958900.0
EU funding (EUR): 1958900.0
Participants: 1
Project status: CLOSED

Smouldering megafires are the largest and longest-burning fires on Earth. They destroy essential peatland ecosystems, and are responsible for 15% of annual global greenhouse gas emissions. This is the same amount attributed to the whole of the European Union, and yet it is not accounted for in global carbon budgets. Peat fires also induce surges of respiratory emergencies in the population and disrupt shipping and aviation routes for long periods, weeks even months. The ambition of HAZE is to advance the science and create the technology that will reduce the burden of smouldering fires. Despite their importance, we do not understand how smouldering fires ignite, spread or extinguish, which impedes the development of any successful mitigation strategy. Megafires are routinely fought across the globe with techniques that were developed for flaming fires, and are thus ineffective for smouldering. Moreover, the burning of deep peat affects older soil carbon that has not been part of the active carbon cycle for centuries to millennia, and thus creates a positive feedback to the climate system. HAZE wants to turn the challenges faced by smouldering research into opportunities and has the following three novel aims: 1) To conduct controlled laboratory experiments and discover how peat fires ignite, spread and extinguish. 2) To develop multidimensional computational models for the field scale (~1 km) and simulate the real phenomena. 3) To create pathways for novel mitigation technologies in accurate prevention, quick detection systems, and simulation-driven suppression strategies. With my proposal, Europe has the chance to lead the way and pioneer technologies against this Earth-scale and important but unconventional source of emissions. I am confident that with the support of ERC, I can deliver the science and excellence needed to tackle this global challenge, and in doing so, I will advance the knowledge frontier, foster innovation and develop new young talent for Europe

Keywords: heat transfer,combustion,fire,carbon emissions,peat
Biocementation for railway earthworks (BioRail)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

In a number of European countries, old railway transport infrastructure earthworks are suffering from serviceability problems or failures and need continuing and costly maintenance/remediation works. This is becoming a major constraint for railway owners and operators, especially in the light of the increased risk of hazards posed by climate change. The hypothesis of this research is that biocementation (a technique that uses natural biological processes to bind soil grains) is a viable and sustainable technique for improving the structural stability of railway earthworks, and hence, the resilience of the EU’s transport infrastructure. The hypothesis will be tested through the application of the technique on earthwork materials of the UK rail network. After establishing improved microbial systems and processes, the project will involve advanced soil testing. The testing will give high quality data on the hydromechanical properties and behaviour of biocemented soils. Careful consideration will be given to the behaviour of the soil under unsaturated soil conditions (soil voids partially filled with water) which has not been researched. The data will be interpreted by constitutive modelling of the soil behaviour. The model will be implemented to commercial software, giving researchers and engineers a useful predictive tool for the analysis and design of biocemented soils. Having assessed the technique and the durability of the biocementation in the laboratory, a significant advance of this research will be the pilot application of the technique on actual railway assets, made accessible by a major owner and operator of railway infrastructure. This novel technique is proposed to be environmentally superior to conventional grouts (which are toxic) and other common soil stabilisers, e.g. cement or lime (linked to high CO2 emissions). Overall it is more sustainable because the micro-organisms used are renewable, environmentally friendly and safe (non-pathogenic).

Keywords: geotechnical engineering,railway earthworks,ground improvement,biological treatment
Drone Alarm and Protection System (DAPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Denmark
Call: Critical infrastructure protection topic 7: SME instrument topic: Protection of Urban soft targets and critical infrastructures (H2020-SMEINST-1-2015, 2015)
Start date: 2016-01-01
End date: 2016-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Drones are moving from being mainly a military technology to a mass market gadget. Whereas demand and applications for drones are fast-growing, the drone market is also raising security and privacy issues. Presently, there are obvious concerns about the possibility of using drones for terrorist attacks in which drones could be equipped with explosives and biological weapons. The development of new and efficient tools able to detect and jam civilian drones used for illegal proposes has become a priority in the security field. MyDefence aims to pursue a major market opportunity through the development of an innovative drone alarm and protection system (DAPS) to be used by security services providers and critical infrastructure owners - public and private sectors - in urban contexts. DAPS is a scalable, networked system with hardware and embedded software algorithms coupled to a graphical user interface. DAPS is able to detect and identify illegal drones around secure areas and to jam the device in a specific wireless frequency range without interfering with other mobile signals and forcing a controlled drone landing. Whereas the core technology is already demonstrated in an operational environment, the further maturation of the concept into a fully commercial and scalable solution is hampered due to the existence of technical and non-technical barriers. Therefore, there is a need to further establish market and regulatory feasibility of the proposed DAPS concept. Also, demonstrate and validate both the technical and economic viability of DAPS at the level of different security applications. Initially, this will require a Phase 1 feasibility study that will give us a clear direction for our demonstration and market replication strategies. If objectives for phases 1 and 2 are successfully achieved, it will represent a significant business opportunity, with an expected sales turnover of €73 million and profits reaching €60.5 million, 6 years after commercialization.

Keywords: security,critical infrastructures,mobile soft targets,drone alarm and protection system,reactive spot,jamming
Data-driven tools for supporting and improving the decision-making processes of investors for financing innovative SMEs (InnoRate)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Italy,Italy,Bulgaria,Korea, Republic of,Belgium,Greece,France
Call: Design and development of a tool to support and improve the decision making process of investors for financing high-growth potential innovative SMES (H2020-INNOSUP-2018-09, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 2998500.0
EU funding (EUR): 2998500.0
Participants: 11
Project status: CLOSED

InnoRate is set on deploying a trusted, objective and recognised service platform across the EU and AC to support and improve the decision-making processes of investors and lenders for vetting, prioritising and providing access to finance to innovative high growth potential SMEs. The suite of digitally-enabled decision support tools and services provided through our platform are underpinned by well-customised innovation assessment and rating methodologies that go beyond the unsuitable, backward-looking and costly practices currently employed, so as to evaluate and signal the technological and business potential and risks of market-creating innovations, efficiently and cost-effectively. To this end, we leverage semantic technology, existing data sources and in-depth human expertise, to minimise the time and resources (human and financial) required by investors and lenders in this respect, reducing knowledge / information asymmetries and ultimately risk premiums paid by innovative project managers. In doing so, our ambition is clearly to disrupt the largely risk-averse financial sector of the EU and AC, enhancing the innovation capacity of high growth technology sectors and SMEs, paving the way for drastical innovations to flourish and placing Europe in the forefront of the global innovation game. To put it simply, we want to bring innovation to finance and finance to innovation.

Keywords: technology rating,innovation assessment and rating methodologies,innovative,disruptive smes,data analytics,information asymmetry,investors,access to finance