Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Doctoral Network Enabling Artificial Intelligence for Electromagnetic Compatibility (PATTERN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Belgium,Czechia,Germany,France,Portugal,United Kingdom
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 3989239.2
EU funding (EUR): 3989239.2
Participants: 20
Project status: SIGNED

PATTERN is a Doctoral Network at the intersection of electromagnetic compatibility, medical engineering, system-safety engineering, and sustainability management. In its push to go beyond the state of the art the project will embed artificial intelligence (AI) into every challenge. The project will research how best to use AI to discover innovative and sustainable solutions to manage electromagnetic interference (EMI) and develop new sets of design guidelines for electromagnetic reliability and the safety of European medical products of the future. PATTERN’s science case is based on the integration and optimization of every key performance indicator (KPI) linked to the two revolutions faced by medical electronics: risk and sustainability. This requires us to think in terms of a trade-off across a new mix of disciplines, to develop innovative solutions, and to consider all the far-reaching societal and technical consequences of a design choice. Until now, even the most high-tech of industries have been forced to manufacture several prototypes and perform tests, because the actual performance of an EMI solution in a product is unknown. A characterization strategy embedded in these new realities is urgently needed. PATTERN is the first training network dedicated to the inclusion of AI as the choice of technology to support these paradigm shifts with a new design philosophy. It answers the recently highlighted, pressing need for trained specialists in the field. PATTERN involves 9 academic Beneficiaries and 9 industrial Associated Partners, across the complete lifecycle of design solutions, from 8 countries. A pan-European approach in a multi-sectoral context is guaranteed (universities, an established start-up, SMEs, and major industries) PATTERN will train a new generation of scientific professionals who can transition between disciplines and take up leading positions in the field of electronics, safety, sustainability and AI, while thinking about design differently.

Keywords: electromagnetic interference and compatibility,electromagnetic risk,high frequency
Development of Bio-based and biodegradable polyethylene and polyesters for food packaging and agricultural applications (Bio2PEs)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Ireland,Serbia,France,United Kingdom,Greece,Slovenia,Cyprus
Call: Nature inspired alternatives for food packaging and films for agriculture (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4363626.5
EU funding (EUR): 3978091.14
Participants: 9
Project status: SIGNED

Bio2PEs aims to revolutionize the plastic sectors by developing bio-based and biodegradable polyethylene (PE) and polyester, directly derived from biomass waste, to combat plastic pollution and advance sustainability. The project will develop four eco-friendly, functional prototypes for food packaging, textile packaging, agricultural mulch, and crop protection membranes, addressing key sectors in need of sustainable alternatives. A crucial part of Bio2PEs is its to conduct a comprehensive environmental, economic, and social impact assessment, covering the entire lifecycle of the materials. The biodegradability in open environments, with ecotoxicity tests will be carried out across four EU climate zones (including soil, freshwater, and marine environments), ensuring the materials meet real-world environmental requirements. To support circularity, Bio2PEs will develop a cellulose-based self-repairing coating to fix scratches, enhance the durability and reusability and significantly improve product lifespan. Bio2PEs will also enhance the recyclability of materials by quantifying the exact content of the recycled material through a fluorescence marker technology. The project will also leverage collaboration with other EU-funded projects, building on social studies of consumer behaviour to design interactive labelling that encourages the adoption of biodegradable materials. Material development data will be shared with an AI tool, developed by a sister project, to expand the data pool and refine material development and biodegradability predictions. This project will support the European Circular Economy Action Plan by fostering scalable, sustainable solutions that reduce waste and plastic pollution while promoting resource efficiency.

Keywords: bio based,biodegradable,polyethylene,polyesters,enzyme,cellulose,starch,chitosan,food packaging,textile,agricultural film,durability,reusability,recyclability,real world biodegradation,
Innovative biotech routes for efficient bio-based solvent production promoting a safe and sustainable European industry. (SOLRESS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Spain,Denmark,Greece,Ireland,Belgium,Finland,Sweden,France,Türkiye
Call: Enlarging the portfolio of commercially produced bio-based SSbD solvents (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 9166120.0
EU funding (EUR): 7044900.0
Participants: 17
Project status: SIGNED

The main objective of the SOLRESS project is to propose an integrated biorefinery system to replace the chemical origin of some of the most widely used solvents in the industry, such as ethyl acetate, ethyl lactate and butyl acetate with a bio-based origin from second generation sugars from post-consumer coffee grounds and lignocellulosic feedstocks. The aim is to reinforce the integration of bio-based research and innovation throughout industrial bio-based systems. Moreover, in the valorisation process of these feedstocks, not only the cellulose fraction will be valorised, but also the hemicellulose fraction to obtain 2 of the most notorious green solvents of today, 2-MeTHF and GVL, from an additional line dedicated to the processing of furfural. The challenges will lie in improving downstream purification (DSP) processes and the techniques employed to achieve a technology that is efficient and cost-competitive with current chemical production systems for solvents. At the end of the project, all solvents will be validated in at least 3 of the most relevant applications (productive processes, formulations and recycling technologies) & at least 3 of the sectors with the greatest use of solvents (paints & coatings, cosmetics & materials processing) with the aim of evaluating its performance in comparison with its fossil-based counterparts, but also as a replacement for other dangerous and toxic solvents, such as NMP, CCL4, THF or toluene. Thus, the ambition of the SOLRESS project is triple: To replace the use of fossil, non-renewable raw materials with specific bio-based feedstocks in the production of some of the most widely used solvents. Offer SSbD alternatives to controversial solvents in terms of danger & toxicity (including the ones under the SVHC & SoCs categories). To improve the competitiveness of these processes by incorporating new methods & technologies that increase efficiency & sustainability, demonstrating their scalability & industrial applicability.

Keywords: bio based solvent,biotechnology,fermentation,enzymes,esterification,furfural,sustainability,biomass
Memristive self-organizing dendrite networks for brain-inspired computing (MEMBRAIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1487500.0
EU funding (EUR): 1487500.0
Participants: 1
Project status: SIGNED

Artificial Intelligence needs a hardware revolution to sustain the ever-growing demand of computing power in our society, where the huge energy consumption and environmental impact of computation with current technologies is unsustainable. In the race toward future computing, bioinspired technologies have been shown as promising hardware solutions for computing beyond the Turing model and the classical von Neumann architectures. Going beyond transistor-centred hardware solutions, the research community is exploring new device concepts and architectures that leverage physical phenomena for computing “in materia” with physical laws to emulate the effectiveness of information processing capabilities of our brain. While arrays of memristive devices realised with a top-down approach represent emerging solutions for the hardware realisation of artificial neural networks, these systems do not emulate the topology and emergent behaviour of biological neuronal circuits where the principle of self-assembly and self-organisation regulates both structure and functions, providing adaptability, efficiency, and robustness. Tackling main challenges of neuromorphic computing, the MEMBRAIN project aim to develop a radically new concept of physically grounded computing nanoarchitecture based on self-organising memristive nanonetworks of dendrites, able to efficiently process information and to store knowledge on the same physical substrate at the matter level through physical laws. Overcoming the concept of nanotechnology as a simple advancement of microtechnology, the ambition is to compute like nature – thermodynamically – to push computation near fundamental limits of efficiency. By establishing a hardware-software codesign framework at the crossroads of material science, machine learning and neuroscience, the aim is to retarget the original goal of neuromorphic computing of creating general-purpose truly intelligent systems that endow dynamic learning and multitasking capability.

Keywords: neuromorphic systems,neuromorphic computing
Coherent Comb for Co-Packaged Optics (COCOPOP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Ireland
Call: EIC Transition Challenge: Chip-scale optical frequency combs (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 2482500.0
EU funding (EUR): 2482500.0
Participants: 1
Project status: SIGNED

The volume of data produced, managed and consumed continues to grow exponentially driven by emerging technologies like machine learning, artificial intelligence and blockchain. Demand for compute power to support these services is growing at 10X every 18 months and datacenter operators are struggling to keep up. Significant challenges have emerged in datacentre networks around bandwidth, signal integrity, power and face-plate density. The migration of the optical interconnect to the board (Co-Packaged Optics, CPO) and to the chip (Optical I/O, OIO) has been proposed as a potential solution, however only a few years into this new paradigm, two of the available dimensions for system scaling (fiber, and wavelength count) are already heavily utilised, posing scaling challenges in the near term. Today’s CPO/OIO systems use intensity modulation/direct detection, but given these pressures, a transition to coherent is inevitable. COCOPOP will deliver the first coherent-capable external laser source (ELS) which benefits today’s systems, and also future-proofs them by enabling full exploitation of the third scaling dimension-bit rate/wavelength-through coherent communication. In doing so, Pilot Photonics will capture for Europe a key position in this strategically important market segment, forecasted to grow to $2.2bn by 2032. Building upon developments in EIC “PICOMB”, the chip-scale frequency comb that will be matured and commercialised through COCOPOP brings many benefits over commercial state of the art DFB arrays, such as unmatched linewidth, relative intensity noise, output power, and wavelength stability derived from the synchronisation and locking of independent lasers with a low linewidth, frequency-locked optical frequency comb (OFC). PILOT has a proven track record in commercially exploiting the outcomes of advanced R&D programmes in the area of chip-scale OFC technology and we intend for the COCOPOP ELS to be on the market within two years of COCOPOP project end.

Keywords: datacentre,photonic integration,comb lasers,co packaged optics
Spatiotemporal analysis of mammalian embryonic development at single-cell level (sc4DMap)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-06-30
Duration (months): 22.0
Total project cost (EUR): 217019.44
EU funding (EUR): 217019.44
Participants: 1
Project status: CLOSED

Mammalian early embryonic development requires exquisite spatiotemporal gene regulation at the level of individual cells. However, it is still unclear and remains a fundamental challenge how cell behaviours govern gastrulation and organogenesis in early embryos. Two techniques have recently been developed to investigate cell fate decisions in early mammalian development (spatial transcriptomics at single-cell level) or to study the dynamic transition from single cells to fully formed organisms (in toto imaging), and if only these two techniques could be combined would we be able to link cell motion with cell state and more completely understand developmental processes. There is precedence for combining live cell imaging with gene expression data in ascidians and annelids, but this has yet to be done, at scale, in more complex mammalian systems. To this end, the proposal aims to investigate early mammalian development by linking spatial transcriptomics and in toto imaging data. This will be the first combination of real-time tracking of cellular dynamics and spatiotemporal gene expression profiles across the developing embryo, thus providing insight into how cells move, interact with each other and how they regulate their own gene expression, ultimately revealing the fate that cells adopt. Accordingly, I will develop a novel integration framework and generate the first cellular-resolution mammalian embryo developmental gene expression map in four dimensions that reflects both cellular dynamics and spatiotemporal gene expression profiles at the single-cell level. Moreover, this work will pave the way for multi-omics integration, which has been increasingly explored but to date is confined to the single-cell space.

Keywords: computational biology single cell analysis spatial transcriptomics multi omics integration bio imaging developmental biology
Revolutionising treatment of orphan autoimmune diseases: TOL2 Immunotherapy for Myasthenia Gravis (TOL2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Problem: Myasthenia gravis (MG) is an orphan autoimmune disease that affects 1 million people worldwide, with no cure available yet. Current treatments are not disease-specific and provide only short-term symptomatic relief at the cost of several side effects. Even the most recent and effective treatments still do not target the source of the problem and come at a very high cost, up to €663,000 per patient per year. Solution: Toleranzia has developed a unique drug development platform that allows the design of disease-specific tolerogens, molecules that can induce lasting immune tolerance in a variety of autoimmune diseases. TOL2 is our lead candidate for treating MG, with proof-of-concept validation in an experimental autoimmune MG rat model. TOL2 is ready for the first-in-human trials and is the focus of this application. TOL2 is the first product in our pipeline. Proof of its efficacy in humans will validate the suitability of our proprietary platform and accelerate the development of additional tolerogens targeting other orphan autoimmune diseases. Value proposition: TOL2 is a non-toxic MG-targeted treatment. It provides long-term remission and has the unique potential to be a cure, promising to enhance the quality of life for patients and significantly reduce medical costs. The way forward: We will evaluate TOL2 in Phase 1/2a clinical trials to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy. This will position us to negotiate a licensing agreement with pharmaceutical companies that can fund Phase 2b/3 trials, prepare TOL2 for market launch and scale its distribution.

Keywords: myasthenia gravis,orphan autoimmune disease,first in human clinical trial
ComfyCell: Novel Bionic Bioreactor for Industrial Stem and Immune Cell Manufacturing (ComfyCell)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 3566995.71
EU funding (EUR): 2496897.0
Participants: 1
Project status: SIGNED

Stem and immune cell therapies are transforming modern medicine, offering new treatments for conditions like cancer, neurodegenerative diseases, and autoimmune disorders. Leveraging cells such as induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), Natural Killer (NK) cells, and T-cells, these therapies hold the potential to address diseases affecting hundreds of millions worldwide. However, the inability to scale the production of these cells presents a major bottleneck in making these life-saving treatments accessible. Stem and immune cells are highly sensitive, struggling with conventional manufacturing processes due to their intolerance to high shear forces, nutrient supply fluctuations, and shifts in oxygen and pH levels. Despite the significant medical advancements, no scalable solution currently exists for industrial production of these cells. iPSC, NK cell, and T-cell cultivation is typically limited to small volumes (2L), and existing techniques rely on outdated bioreactor technologies initially designed for more robust cells. Approaches like conventional stirred tank reactors (STRs), wave bags, and vertical wheel bioreactors introduce high shear forces or require labour-intensive reconfiguration, making them inadequate for industrial stem and immune cell manufacturing. BioThrust’s ComfyCell bioreactor is designed to address this challenge, offering a revolutionary solution for cultivating sensitive stem and immune cells at industrial scales. As the first bioreactor to simulate the natural environment of these delicate cells, ComfyCell enables more efficient, high-yield production which is urgently desired by the market. By securing EIC Accelerator funding, BioThrust will be able to validate ComfyCell’s scalability and performance through pilot programs in industrial scales, incentivizing early adopters with cost-saving opportunities and valuable case studies.

Keywords: bionic bioreactor,industrial cell therapy manufacturing,stem and immune cell therapies,induced pluripotent stem cells ipscs,mesenchymal stem cells mscs,natural killer nk cells,car t cells
Single atom based nanohybrid photocatalyts for green fuels (SAN4Fuel)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Czechia,Italy,Germany
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 1498993.75
EU funding (EUR): 1498993.75
Participants: 4
Project status: SIGNED

The aim of this Twinning proposal entitled ‘Single Atom-Based Nanohybrid Photocatalysts for Green Fuels’ (SAN4Fuel) is to establish excellent collaborative research partnership that will link together two world-renowned research groups—Prof. Schmuki’s from the German Friedrich–Alexander University Erlangen (FAU) and Prof. Fornasiero’s from the Italian University of Trieste (UNITS)— with a research team from the Czech Palacky University Olomouc (UPOL), led by Dr. Kment, representing the Widening Country applicant, and another Czech outstanding group from VSB – Technical University of Ostrava (VSB), led by Prof. Zboril. Although the UPOL team has achieved a number of highly valuable scientific results, particularly in the field of hybrid nanostructures for photocatalysis, it still lags behind the most prestigious research teams in the area of sustainable and green energy. In this regard, it has been shown that incorporation of transition metals co-catalysts in the form of single atoms (SAa) into photocatalysts remarkably increases their activity. However, the UPOL teams lacks this necessary expertise, which represents one of the biggest breakthroughs in the field of CO2—free sustainable energy. By contrast, the FAU, UNITS, and VSB teams are considered leaders in the field of SA-based photocatalysts, exploiting semiconductors and carbon based materials. Moreover, VSB possesses the most powerful supercomputer in Europe, which will bring insight into the still unknown properties of SAs embedded in photoactive supports and the mechanistic phenomena related to two target reactions such as photocatalytic water splitting and CO2 reduction. FAU, UNITS and VSB’s expertise, infrastructure, knowledge, and best practice will be fully shared with UPOL to significantly enhance its scientific profile, attractiveness for other talented researchers, and competitiveness in the area of European grants.

Keywords: photocatalysts,single atom catalysis,photocatalytic water splitting,co2 reduction,carbon based materials,photoactive semiconductors,hybrid nanostructures