Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ink-Jet printed supercapacitors based on 2D nanomaterials. (2D-Ink)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-04-01
End date: 2016-09-30
Duration (months): 18.0
Total project cost (EUR): 149774.0
EU funding (EUR): 149774.0
Participants: 1
Project status: CLOSED

This proposal will determine the technical-economic viability of scaling-up ultra-thin, ink-jet printed films based on liquid-phase exfoliated single atomic layers of a range of nanomaterials. The PI has developed methods to produce in liquid nanosheets of a range of layered materials such as graphene, transition metal oxides, etc. These 2D-materials have immediate and far-reaching potential in several high-impact technological applications such as microelectronics, composites and energy harvesting and storage. 2DNanoCaps (ERC ref: 278516) has demonstrated that lab-scale ultra-thin graphene-based supercapacitor electrodes result in unusually high-power and extremely long device life-time (100% capacitance retention for 5000 charge-discharge cycles at the high power scan rate of 10,000 mV/s). This performance is an order of magnitude better than similar systems produced with conventional methods which cause materials restacking and aggregation. A following ERC PoC grant (2D-USD, Project-Number 620189) is currently focussed on up-scaling the production of thin-films deposition methods based on ultrasonic spray for the production of large-area electrodes for supercapacitors applications. In this proposal we want to explore the new concept of manufacturing conductive, robust, thin, easily assembled electrode and solid electrolytes to realize highly-flexible and all-solid-state supercapacitors by ink-jet printing. This opportunity is particularly relevant to the electronics and portable-device industry and offers the possibility to solve flammability issues, maintaining light weight, flexibility, transparency and portability. In order to do so it will be imperative to develop ink-jet printing methods and techniques. We believe our combination of unique materials and cost-effective, robust and production-scalable process of ultra- thin ink-jet printing will enable us to compete for significant global market opportunities in the energy-storage space.

Keywords: ink jet printing,supercapacitors,energy,portable electronics
Illuminating Atomic Scale Processes in Liquids and Gases (EvoluTEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2024-02-29
Duration (months): 83.0
Total project cost (EUR): 1755278.75
EU funding (EUR): 1755278.75
Participants: 1
Project status: SIGNED

EvoluTEM: Illuminating Atomic Scale Processes in Liquids and Gases Objective 1: To build new capability in atomic resolution environmental imaging and analysis. Objective 2: To apply this platform to synthesise new photonic nanomaterials with enhanced performance. The vision is to design, construct, and make available the next generation of multifunctional in situ specimen holders for the scanning /transmission electron microscope (S/TEM). This new experimental resource will enable ground-breaking characterisation of complex nanoscale reactions under realistic and relevant environmental conditions using a lab-on-a-chip configuration. By providing a platform with unparalleled atomic scale imaging and simultaneous elemental analysis capabilities, as well as flexible in situ (temperature, pressure, and illumination) environments, this effort will provide an experimental module for a wide range of breakthrough in situ nanomaterials experiments. Motivating this work is the goal of being able to fully characterize the synthesis of novel photonic 2D materials, optoelectronic nanoparticles, and photoactive organic-inorganic perovskites. This research could lead to a new level of mechanistic understanding, providing knowledge to realize routes for the production of new nanostructures, with properties that can be optimally tailored for photonic applications (photovoltaics, light emission or optoelectronics). This ambitious research program is only possible because of the principal investigators outstanding electron microscopy expertise, coupled with the world leading nanofabrication capabilities and in situ imaging facilities at the University of Manchester. The project has been structured into five work packages (WPs) with each having well-defined milestones and deliverables.
Open Responsible research and Innovation to further Outstanding kNowledge. (ORION)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Italy,Spain,Germany,Spain,Sweden,Czechia,United Kingdom
Call: Opening Research Organisations in the European Research Area (H2020-SwafS-2016-1, 2016)
Start date: 2017-05-01
End date: 2021-09-30
Duration (months): 53.0
Total project cost (EUR): 3157301.25
EU funding (EUR): 3157301.25
Participants: 9
Project status: CLOSED

The ORION project focuses on triggering evidence-based institutional, cultural and behavioural changes in Research Funding and Performing Organizations (RFPOs), targeting researchers, management staff and high-level leadership. Our long term vision is to “embed” Open Science and Responsible Research and Innovation (RRI) principles in RPFOs’ policies, practices and processes to organise and do research. Since science is about creativity and collaboration, we will extend further collaboration in research by engaging in co-creation experiments with multiple stakeholders. We will try out different “open-experiments” in three key challenge areas: 1) Opening up the research engine – making RFPOs more permeable to receiving input from numerous, distinct stakeholders; 2) Identifying risks and opportunities presented by disruptive technologies; 3) Running multi-stakeholder projects based on citizen science. After an initial assessment and benchmarking exercise, we will use our three challenges as case studies to explore different co-creation methods with multiple stakeholders, and spark dialogue between unusual combinations of actors (e.g. funders and the public, or researchers, industry and the public). We will apply the RRI principles on the scientific process and governance, identify drivers and barriers, interests and values, and eventually produce “prototypes” for current and future societal challenges. Toward raising knowledge on RRI in practice and enriching the current training, we will generate innovative training programmes and modules based on the peer-to-peer learning approach, targeting young researchers and professionals at funding agencies. The consortium, which involves RPFOs from different countries, representatives of RRI stakeholders and experts in social sciences, will move forward to achieve and embed Open Science.

Keywords: co creation,institutional change,open science
Regulatory genomics during Drosophila embryogenesis: dissecting enhancer-promoter interactions (Enhancer3D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-05-01
End date: 2024-12-31
Duration (months): 80.0
Total project cost (EUR): 1770375.0
EU funding (EUR): 1770375.0
Participants: 1
Project status: SIGNED

In eukaryotes, the complex regulation of temporal- and tissue-specific gene expression is controlled by the binding of transcription factors to enhancers, which in turn interact with the promoter of their target gene(s) via the formation of a chromatin loop. Despite their importance, the properties governing enhancer function and enhancer-promoter loops in the context of the three-dimensional organisation of the genome are still poorly understood. My recent work suggests that (i) developmental genes are often regulated by multiple enhancers, sometimes located at great linear distances, (ii) the spatio-temporal activity of a large fraction of those enhancers remains unknown, (iii) enhancer-promoter interactions are usually established before the target gene is expressed and are largely stable during embryogenesis, and (iv) stable interactions seem to be associated with the presence of paused RNA Polymerase II at the promoter before gene activation. Building upon these results, we propose to advance to the next level in the dissection of enhancer-promoter interaction functionality in the context of Drosophila embryogenesis. Specifically, we will address three important questions: (i) What determines the specificity of promoter-enhancer interactions in a complex genome? (ii) Are enhancer-promoter interactions tissue-specific, and what are the drivers of this specificity? (iii) Are all enhancer-promoter interactions functional, and how does the activity of an enhancer relate to the expression of the gene it interacts with? To this end, my group will apply an interdisciplinary approach, combining state-of-the-art methods in genetics and genomics, including novel single-cell techniques, using Drosophila embryogenesis as a model system. Our results will provide a unique view of the functionality of enhancer-promoter interactions in a developing embryo, a significant step towards understanding the link between chromatin organisation and transcription regulation.

Keywords: drosophila,enhancer,chromatin organisation,transcription,development
REVOsdr - taking drones beyond and bringing them safely back (REVOsdr)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Portugal
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The use of professional drones for the inspection of infrastructure and surveying has been increasing dramatically over the last years. However, there are technological limitations in the wireless communication systems that connect the drone and its operator. The inspection drone can't fly further than a few hundred meters from the operator, resulting in economically unviable services. If an inspection drone attempts to cover longer distances (kms), the limitations of current communication systems endanger the infrastructure, people on the ground, and the drone itself. From the market perspective, these limitations bound innovation and growth of drone-based businesses. The majority of the drone manufacturers adopted communication systems based on readily available Wi-Fi solutions, which is not a reliable technology for real-time remote operation of vehicles. Wi-Fi is highly susceptible to interference and was designed for short-range communication with intermittent transmission. A drone requires a continuous long-range data link. Alternative communication solutions, such as cellular and satellite, depend on the coverage of the services providers and lack flexibility. TWEVO is a high-tech start-up that has developed a wireless modem for drone communications called REVOsdr, which provides reliable and secure long-range real-time connectivity. REVOsdr allows an inspection drone to safely cover several kilometres, reducing inspection OPEX by as much as 50%. REVOsdr is a wireless communication technology that enables and scales the commercial value of drone-based services. With our innovation, we want to disrupt this 140M€-worth drone data link market and its Wi-Fi trend.

Keywords: drone,wireless data link,beyond visual line of sight,inspection and surveying
Systematic discovery of functional elements in RNA virus genomes: an Encyclopedia of RNA Virus Elements (ERVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 1780000.0
EU funding (EUR): 1780000.0
Participants: 1
Project status: CLOSED

Identification of the full complement of genes and other functional elements in any virus is crucial to fully understand its molecular biology and guide the development of effective control strategies. Our recent discoveries of new 'hidden' genes in the potyviruses, alphaviruses, arteriviruses, flaviviruses and influenza A virus have demonstrated that, even in the most well-studied and economically-important viruses, small overlapping genes can remain undetected throughout decades of research. Comparative computational analyses can be used to efficiently identify hidden features and target experimental analyses, thus saving time and cost, and minimizing animal experiments. With the rapid increase in sequencing data, for the first time it is now possible to map out at high resolution functional elements genome-wide in hundreds of important virus species. Our research involves the development of powerful new tools for virus comparative genomics, and the application of these tools to uncover hidden genes and other functional elements in RNA virus and retrovirus genomes. Hidden genes are often translated via non-canonical mechanisms, such as programmed ribosomal frameshifting, and we are particularly interested in discovering and characterizing new types of non-canonical translation. Deciphering these 'exceptions-to-the-rule' enhances our understanding of the mechanics of protein synthesis. Further, these novel mechanisms may also be relevant to cellular gene expression. The goals of this project are: 1) To computationally identify all 'hidden' genes and major functional non-coding elements in the genomes of RNA viruses and retroviruses of medical, veterinary and agricultural importance. 2) To experimentally characterize the most interesting new features. 3) To characterize novel translation mechanisms utilized by RNA viruses. 4) To develop web interfaces to our software and an interactive RNA virus comparative genomics database.

Keywords: rna viruses,comparative genomics,genetic recoding,ribosomal frameshifting,non canonical translation,overlapping genes,functional rna elements
New microfluidic tools for characterization of protein-lipid interactions (MicroProtLip)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Cellular function and malfunction depends crucially on the interactions of proteins and other cellular components, specifically with lipid membranes. Such interactions are a key to the compartmentalization of a wide range of cellular mechanisms into discrete organelles, allowing to maintain homeostasis. In spite of implications to life sciences and drug discovery our current understanding of protein–lipid interactions is limited. This is primarily due to the challenges imposed by existing methods for determining the fundamental interactions of a wide range of proteins and lipid bilayers due to the high level of heterogeneity of the formed complexes. Recent advances in the development of microfluidic techniques for characterisation of biomolecular complexes together with sensitive optical detection methods open new possibilities for fundamental studies of protein–lipid interactions. The main objective of the proposed project is the development of a transformative microfluidic platforms dedicated for the study of interactions of lipid membranes with protein molecules. Experienced Researcher aims at the implementation of microfluidic technologies: micro free flow electrophoresis and nano deterministic lateral displacement, for the parallel development of two types of platforms. The development of the platform will be highlighted by addressing exemplary fundamental questions in molecular biology of interest that concern a wide range of aspects of mechanism of protein–lipid interaction. The realization of the objectives will be based on close collaboration between academic and non-academic sectors, in pursue to bridge the gap between fundamental and applied research. This action will set up a tight collaboration between the University of Cambridge (UCAM) and Fluidic Analytics Limited (FAL) who have pioneered the use of commercial microfluidic platforms for efficient characterization of biomolecular interactions.

Keywords: microfluidics,microfluidic diffusional sizing,micro free flow electrophoresis,microfabrication,protein lipid interactions,lipid vesicles,neurodegenerative diseases
Persia and Babylonia: Creating a New Context for Understanding the Emergence of the First World Empire (Persia and Babylonia)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1999733.0
EU funding (EUR): 1999733.0
Participants: 1
Project status: CLOSED

The Persian Empire (539-330 BCE) represented a new political order in world history. At its height, it united a territory stretching from present-day India to Libya. It was three times as large and twice as long-lived as the previously most successful polity (Assyria), and it would take 2,000 years before significantly larger empires emerged in early modern Eurasia. What explains Persia’s success? This question eludes scholarship due to a lack of evidence and a lack of engagement. Since this Empire unified for the first time in history millions of people under its rule – a condition that became a recurring experience of humanity – understanding Persia’s success transcends its intrinsic relevance to the period in question. The principal reason why an effective engagement with this question is presently impossible is the lack of data. The PERSIA AND BABYLONIA project presents a substantial new data set that allows us, for the first time, to contextualize the emergence of the Persian Empire as a complex social process, shifting away from understandings of the Empire as a one-dimensional, state-initiated construct. This data derives from cuneiform textual sources that were produced in Persia’s most important periphery – Babylonia. A key analytical device in our work will be to compare Persian responses to those of the Assyrians, who were unable to establish control of Babylonia a century earlier. By combining a long-term with a deeply contextualized perspective, we will be able to draw out the distinctive efficiency of Persian rule, within the long history of this particular region. In addition to making a significant step towards understanding the emergence of Ancient Persia, we will develop a much-needed research tool for historians of empire and society in the ancient world.

Keywords: ancient near eastern history,assyriology
Visual and vestibular processing in secondary visual cortex (VestibVis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Spatial navigation requires the integration of visual and vestibular inputs to build a representation of space. Connectivity studies have shown that the secondary visual cortex (V2) of mice receives bottom-up inputs from primary visual cortex and anterior thalamus, conveying respectively visual and vestibular information, and feedback top-down inputs from the retrosplenial cortex. The aims of this project are to determine the visual and vestibular tuning of layer 5 pyramidal neurons in V2, how these inputs are recruited and interact when the mouse is engaged in a spatial navigation task, and how they are modulated by retrosplenial inputs. This will be accomplished using a combination of population calcium imaging or whole-cell patch-clamp recordings of layer 5 neurons, coupled with sensory stimulation and optogenetic activation or inhibition of sensory or top-down inputs and behavioural experiments.

Keywords: visual cortex,vestibular,retrosplenial cortex,layer 5,two photon imaging,spatial navigation