Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A game change in continuous biosensing: Molecularly engineered affinity-based nanoswitches for personal monitoring (CONSENSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Israel,Germany,Switzerland,Belgium,Belgium,Netherlands,Netherlands,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-08-31
Duration (months): 54.0
Total project cost (EUR): 4030909.32
EU funding (EUR): 4030909.3200000003
Participants: 10
Project status: SIGNED

Generic technology that allows continuous sensing of a wide range of biomolecular parameters could revolutionise patient monitoring and enable truly personalised therapy. Commercial sensors are available for continuous monitoring of glucose, but do not exist for other molecules that are important for monitoring disease status and treatment effect, including peptides, proteins, hormones, and drugs. The ambition of CONSENSE is to provide a game change in continuous biomolecular sensing by combining advanced molecular engineering with tailored optical detection technologies to yield generic, affinity-based biosensing technologies. CONSENSE will focus on the construction of biomolecular nanoswitches that translate molecular binding into robust and well-defined conformational changes at length scales that can be detected by selected optical detection methods, providing unique possibilities to distinguish between specific and nonspecific binding. While the applications for this new technology are wide and varied, within CONSENSE we will focus on immune monitoring in critical care settings, where patients have an urgent need for continuous monitoring related to inflammation and immunotherapy. CONSENSE brings together internationally leading pioneers in biomolecular switch engineering with research groups that have an excellent track record in biosensor development using advanced optical approaches, including two high-tech companies that have spun out from these groups. The consortium is completed by a strong network of partner industries and organisations, including four large medical technology companies, clinical experts, and six SMEs providing specific technological expertise and training. The consortium will provide exceptional training to 15 ESRs, allowing them to develop professionally and perform world-class research that will fundamentally advance the field of continuous biomolecular monitoring for healthcare.

Keywords: molecular switch,protein engineering,dna nanotechnology,chemical biology,optical detection,single molecule detection,nanoplasmonics,nanophotonic array,immuno monitoring
Competitive Dynamics in the Informal Economy: The case of Illegal Pharmaceutical Drugs (IllegalPharma)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Spain
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-05-01
End date: 2023-01-31
Duration (months): 69.0
Total project cost (EUR): 1374185.0
EU funding (EUR): 1374185.0
Participants: 1
Project status: CLOSED

This project aims to develop a competitive dynamics theory of the informal economy, which is currently lacking in academic research. Specifically, this project will adopt an institutional theory perspective to better understand three fundamental outcomes in the informal economy: market entry (illegal businesses’ decision to be active in a specific niche), price competition (price differentials between legal and illegal products), and product quality (quality of products sold in illegal businesses). The main conceptual proposition suggested in this project is that selling products through illegal means may still be perceived as a legitimate activity. Building on this statement, it will be proposed that the degree in which actors perceive the sale of an illegal product as a more or less legitimate activity will influence (1) entrepreneurs’ decision to illegally enter such market, (2) consumers’ willingness to pay for such illegal product (i.e., price differential versus the legal version of the product) and (3) manufacturers’ motivation to keep quality standards for that illegal product. The empirical setting for this study will be the illegal sale of pharmaceutical drugs. The sale of illegal pharmaceuticals accounts for more than 10% of the medicines market and over €30 billion in annual earnings (World Health Organization, 2003). It represents one of the biggest challenges for societies in that, attending to the WHO’s Department of Essential Medicines and Health Products, anywhere from 100,000 to a million people die every year due to falsified drugs. Accordingly, this study aims to provide two main contributions: (1) an academic contribution by developing a radically new theory of the competitive dynamics in the informal economy, and (2) a practical contribution by providing a better understanding of the determinants of the informal economy that could help policy makers and regulators in their goal of fighting the trading of illegal medicines.

Keywords: informal economy,pharmaceutical industry,legitimacy
intelligent Converged network consolIdating Radio and optical access aRound USer equipment. (iCIRRUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Cyprus,Slovenia,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Smart optical and wireless network technologies (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3832196.25
EU funding (EUR): 3832195.0
Participants: 12
Project status: CLOSED

To meet the high throughput demands envisaged for 5G networks, with increased user densification and bandwidth-hungry applications, while at the same time reducing energy consumption, iCIRRUS proposes an intelligent Cloud-Radio Access Network (C-RAN) that brings together optical fibre technology, low-cost but highly flexible Ethernet networking, wireless resource management for device-to-device (D2D) communication (incl. the use of mm-wave spectrum) and the use of virtual mobiles in the cloud. The iCIRRUS C-RAN introduces the use of Ethernet in the fronthaul/midhaul (for radio signal transport), to minimise cost and make available pluggable and in-device monitoring, and intelligent processing to enable self-optimizing network functions which maximise both network resource utilisation and energy efficiency. To exemplify the attractiveness of the proposition, iCIRRUS focusses on D2D communication in the wireless domain, an important work area in current standardisation, where low latency is known to be a significant factor. The latency and jitter in the iCIRRUS Ethernet-based C-RAN will be an important focus of the research work in the project, with current 5G performance targets in mind; for D2D communications, the task will be to minimise control latency and overhead. A major obstacle for C-RANs is the bit-rate of the digitised radio signals that would be required for 5G – of the order of 100 Gb/s and iCIRRUS will examine the architectural and technological questions surrounding this requirement. Wireless resource management will be investigated, together with mobile device caching and mm-wave D2D mesh networks, to reduce latency as well as load on the infrastructure. Finally, the intelligent network functions in ICIRRUS can interact with mobile cloud processing, and further offloads of infrastructure communications can be realised through virtualising mobiles in the cloud as clones, and performing communication tasks between clones.

Keywords: centralised radio access network,ethernet fronthaul,cpri,device to device communication,mobile cloud
A cost-effective process for methanisation of unexploited agricultural waste. (DualMetha)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Context Biogas production level in the EU has grown considerably in the past ten years to over 16 Mtoe, with optimistic forecasts predicting that by 2030 Europe will produce over 40 Mtoe. Problem The production of biomethane from organic waste matter faces a series of practical problems which are holding back its growth: - Cannot treat all wastes. Straw waste represents a massive biogas potential, but less than 5% is currently used for Biogas production. - Foreign objects often enter into the system, causing damage and increasing maintenace costs - Have high energy costs - Require several treatment stages, which increase the CAPEX and OPEX. Solution – the DualMetha Plant We have developed and patented a simplified, biomethane production process that: • cuts down some of the waste pre-treatment stages, • allows for the methanation of all types of biomass including straw, • does not break when foreign objects are introduced • and has low OPEX (50% less in maintenance, wear, repairs, electricity costs). DualMetha represents the opportunity to turn unexploited organic waste into biogas. The aim of the phase 1 project is to improve our understanding of the EU market for Biogas, identifying regional market variations in terms of purchase decision makers, appropriate business models, pricing structure and identifying which are the most attractive markets for us to use as a beachhead. We estimate that, only considering crop residual waste (straw) that DualMetha plants could supply 80Mtoe. We aim to install 75 plants by 2025.
InterCONnected NEXt-Generation Immersive IoT Platform of Crime and Terrorism DetectiON, PredictiON, InvestigatiON, and PreventiON Services (CONNEXIONs)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Spain,Italy,Israel,Spain,Germany,Belgium,Romania,Moldova, Republic of,Greece,Greece,Greece,France,United Kingdom,United Kingdom,Portugal
Call: Technologies for prevention, investigation, and mitigation in the context of fight against crime and terrorism (H2020-SEC-2016-2017-2, 2017)
Start date: 2018-09-01
End date: 2022-02-28
Duration (months): 42.0
Total project cost (EUR): 4999390.0
EU funding (EUR): 4999390.0
Participants: 21
Project status: CLOSED

CONNEXIONs aims to develop and demonstrate next-generation detection, prediction, prevention, and investigation services. These services will be based on multidimensional integration and correlation of heterogeneous multimodal data, and delivery of pertinent information to various stakeholders in an interactive manner tailored to their needs, through augmented and virtual reality environments. The CONNEXIONs solution encompasses the entire lifecycle of law enforcement operations including: a) pre-occurrence crime prediction and prevention b) during-occurrence LEA operations c) post-occurrence investigation, and crime-scene simulation and 3D reconstruction. CONNEXIONs will meaningfully enhance operational and (near) real-time situational awareness, through automated identification, interpretation, fusion and correlation of multiple heterogeneous big data sources, as well as their delivery via immersive solutions. Such multimodal data include Surface/Deep/Dark Web and social media content in 7 languages (EN, FR, DE, PT, RO, ES, AR), data acquired by Internet of Things (IoT) devices, and digital evidence. CONNEXIONs will also provide chain-of-custody and path-to-court for digital evidence. The Project will adopt ethics and privacy by-design principles and will be customisable to the legislation of each member state. CONNEXIONs will be validated in field tests and demonstrations in 3 operational use cases: a) counter-terrorism security in large scale public events b) human trafficking investigations and mitigation c) crime investigation and training through 3D scene reconstruction. Extensive training of LEAs' personnel, hands-on experience, joint exercises, and training material will boost the uptake of CONNEXIONs tools and technologies. With a Consortium of 8 LEAs from 7 European countries, 5 Research/Academic partners, and 4 industry partners, CONNEXIONs delivers a strong representation of the challenges, requirements and tools to meet its objectives.

Keywords: improved near real time situational awareness,crime scene simulation and 3d reconstruction,augmented and virtual reality,counter terrorism is large scale events,human trafficking investigation
Accurate Geofluid Properties as key to Geothermal Process Optimisation (GEOPRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Iceland,Germany,Germany,Switzerland,Norway,Norway,Türkiye,Norway,France,United Kingdom,United Kingdom
Call: Optimising manufacturing and system operation (H2020-LC-SC3-2019-RES-TwoStages, 2019)
Start date: 2019-11-01
End date: 2023-10-31
Duration (months): 48.0
Total project cost (EUR): 4898982.5
EU funding (EUR): 4898982.5
Participants: 12
Project status: SIGNED

Rigorous thermodynamic models are crucial to understanding the properties of geofluids, as part of planning for exploration, design and operation of geothermal energy facilities. However, these models are currently incomplete and do not give accurate enough results for reliable planning; Operators commonly need to carry out empirical, site-specific trials instead, which are costly and occur ‘after the fact’, reducing their effectiveness. The GEOPRO project will produce a set of integrated knowledge based design and operation tools to allow the geothermal industry to explore, design and operate systems more effectively, reducing the LCOE to competitive levels. To do this, we will firstly generate new experimentally derived datasets to fill gaps in current knowledge of the heat and mass transfer behaviour of complex and highly concentrated fluids under hot and superhot conditions. These will provide next-generation equations of state, which we incorporate into a set of operation and exploration tools. To address these objectives, we have assembled a consortium that combines excellent strength in all areas from the systematic and accurate experimental determination of fluid properties through beyond-industry standard reservoir modeling to process optimization and flow assurance modeling. Our consortium also contains geothermal industry partners, on whose sites we will verify the accuracy of the toolsets. We will then incorporate these into open-access knowledge base for use and development across the industry. The geothermal industry will use these new tools to benefit from: the capability to better explore and ‘vector in’ on new resources; the ability to predict the return on a well more reliably for investment decisions; control-oriented simulations to reduce the engineering overkill currently required; improved energy extraction through knowledge of the real production constraints.

Keywords: geothermal fluids,geochemistry,thermodynamics,fluid property experiments,reaction kinetics,multi phase flow,flow asgeothermal fluids,lcoe,thermodynamic properties,knowledge based engineering
Circular Plastics Network for Training (C-PlaNeT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Germany,Germany,Germany,Belgium,Greece,Belgium,Netherlands,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2024-05-31
Duration (months): 53.0
Total project cost (EUR): 3937681.08
EU funding (EUR): 3937681.08
Participants: 9
Project status: SIGNED

Bringing plastics into the circular economy is one of the great challenges of our age. C-PlaNeT lays the foundations for a New Plastics Economy through a European Joint Doctoral Programme that trains 15 Early Stage Researchers (ESRs) to become part of a new generation of scientists, engineers and policy makers for the EU’s circular economy, which must include the design, processing, use and reuse of plastics. C-PlaNeT focuses on excellent international research, training in complementary skills, including entrepreneurship and the translation of research into policy, international as well as cross-organisational and intersectoral mobility, active involvement of the non-academic sector, dissemination, awareness raising and public outreach. As a truly multidisciplinary proposal, C-PlaNeT is well-balanced across different scientific fields of equal importance: chemistry, social sciences, engineering, political sciences, product design and business model development. Moreover, through the 20 non-university partners, C-PlaNeT is anchored across all sectors relevant for the Circularity of Plastics. All ESRs will advance the current state-of-the-art of their respective fields, which together cover the whole life cycle of plastics. To this end, they are supervised by at least 2 promotors from 2 universities and a partner outside university, with whom they will also take an internship. They will participate with each other in a cooperative learning scheme to take their research beyond the borders of their own respective disciplines and gain a holistic appreciation for the complex issue of Plastics in a Circular Economy. As such C-Planet has the ambition to be a game changer for the circularity of plastics as a material resource, based on and excellent and multidisciplinary research and training programme.

Keywords: circular economy,plastics,consumer practices,recycling,design for,from recycling
Taking SynOil to the market: Synthetic oil (SynOil) from plastic waste with the molten zinc reactor (SynOil)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In Europe, the US and elsewhere, many municipals are sending more plastic waste to landfill or incineration for lack of other options. This reversal is due to the Dec. 2017 Chinese import ban on plastic waste. Moreover, the regulatory pressure on plastic recycling is increasing: in May 2019 the EU and most other states signed an agreement, which classifies plastic waste as hazardous, greatly reducing the capabilities of EU member states to export plastic waste to the third world and, hence, requiring treatment within the EU. In summary, the burden of dealing with plastic waste will shift back to Europe, the US, Canada and Japan presenting a large, global business opportunity for Composite Recycling Ltd (CRL). Product & value proposition: CRL owns the patent to turn plastics waste into synthetic oil by treatment with molten zinc. This innovation named SynOil delivers highly profitable plastic waste incl. non-recyclable plastics to synthetic oil plants as SynOil is the fastest possible solution to treat plastic wastes due to heat transfer. Target-users of SynOil are plastic waste recyclers, municipals and industrial plastic waste producers worldwide. Market size: Worldwide about 100 SynOil plants are required. The financial returns for an operator are excellent with IRR’s over 25%depending mainly on throughput, but also local market conditions and other factors. The next step in the SynOil project is the demonstrator scale unit – followed by commercialization. The funding requirement for the demonstration stage is between €1.5 and 8.0 million. The higher figure of €8.0 million is for the special case of a commercial plant for large plastic pieces. Company: CRL was founded in 2012 to commercialize our waste tyre and printed circuit boards (PCBs) recycling processes. SynOil – waste plastic to oil or diesel – is yet another pillar in our growth strategy. Business model & commercialization: CRL will use the licence and design business model to commercialize SynOil.

Keywords: plastic waste to fuel production
PRECISION MANUFACTURING OF MICROENGINEERED COMPLEX JOINT IMPLANTS (JOINTPROMISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Greece,Belgium,France,Netherlands,United Kingdom
Call: Regenerative medicine: from new insights to new applications (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 7901115.0
EU funding (EUR): 7901115.0
Participants: 6
Project status: SIGNED

There is convincing evidence, in animal models and in humans, that deep osteochondral defects of the joint surface lead to a high rate of osteoarthritis (OA) over time. The disease process in OA, the most prevalent arthritic disease affecting 25% of the adult population, involves the entire joint affecting both the articular cartilage and the underlying bone. Hence it is crucial to consider the entire osteochondral unit as a target for repair. Tissue engineered implants could provide a solution for the regeneration of this type of defects and prevent the development of OA. This project aims to address this unmet clinical need by developing complex joint implants that will possess the spatially inbuilt biologic information for regenerating these challenging defects. Breakthroughs in organoid technologies have allowed the development of cartilaginous microtissue structures that can predictively execute regenerative programmes upon implantation. These microtissues can be used as building blocks for bottom-up 3D bioprinting of living joint implants. In order to be able to produce scaled-up implants containing at the same time a highly precise structure, integration of bioprinting technologies is needed. Moreover in order to cover rising clinical demand the whole manufacturing process, which is mostly manual today, will need to be automated adopting robotics, bioprinting and bioreactor technologies. In order to demonstrate implant feasibility and efficacy, large osteochondral defect repair will be studied in the minipig, a large animal model relevant to the patient. Taken together we strive to develop an automated, GMP-grade platform producing large, patterned and vascularised joint implants providing also a paradigm shift for generic automated manufacturing of organoid-based tissue implants. JOINTPROMISE paves the way for high-volume, affordable production of entire biological joints, addressing a major socioeconomic challenge of the European ageing society.

Keywords: osteochondral defects,osteoarthritis,organoids,3d bioprinting,robotics,bioreactors,upscaling and manufacturing,large animal models,atmps,stem cells