Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Aligned Roll-to-Roll Shear Coating of Nanotubes (ARENA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-07-01
End date: 2018-12-31
Duration (months): 18.0
Total project cost (EUR): 149963.0
EU funding (EUR): 149963.0
Participants: 1
Project status: CLOSED

Carbon Nanotubes (CNTs) are considered to be one of 21st century’s most promising materials and over the past decade, tremendous scientific advances have been achieved in the synthesis and processing of these materials. However, the uptake of CNTs by high-tech industry is hampered by a lack of high-throughput processes to structure CNTs into aligned and densely packed assemblies. This is key to fabricate next generation CNT devices, and to date, the CNT community is still struggling to achieve this, especially over large areas. As part of the ERC Starting Grant HiENA, we are pioneering a potentially disruptive strategy to control the packing of CNTs and to fabricate large area films of aligned CNT. In this process, we start from newly developed ultra-high density dispersion of CNTs which can form liquid crystal domains. These domains are aligned by controlling shear in a custom designed coating head which then continuously dispenses the CNTs on a roll-to-roll coater which was recently purchased by the host group. To quantify the performance of the proposed technology, the parameter space of the coating process will be mapped out in terms of throughput, film thickness, uniformity, and conductivity. Finally, we devised a two-step commercialisation plan which targets less to more demanding markets including thin film heaters, ultra-lightweight electro-magnetic shields, as well as interconnects and sensors for flexible electronics. We believe this project is timely on the one hand because of the technology push of improved CNT processing and on the other hand by the pull from several new markets including flexible electronics and the rise of the Internet of Things which will require a drastic increase in low cost electronic manufacturing technologies. The ERC Proof of Concept grant ARENA aspires to contribute to this need by taking a leap forward in the large scale processing of next generation CNT devices.

Keywords: nanotechnology,carbon nanotubes,roll to roll coating
Opening the Third Generation: The Search for Long-Lived Fundamental Particles (OPEN3GEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-03-01
End date: 2025-08-31
Duration (months): 78.0
Total project cost (EUR): 1747286.0
EU funding (EUR): 1747286.0
Participants: 2
Project status: SIGNED

The OPEN3GEN project will access an entirely new phase space to discover long-lived particles at the Large Hadron Collider. Current data-recording algorithms (“triggers”) do not record directly this type of event at the LHC. My team and I will maximise the experimental sensitivity by developing trigger strategies and reconstruction methods to yield the first datasets that will be sensitive to long-lived particles decaying to third generation particles. This will result, for the first time, in limits on, or observations of, long-lived particles in new lifetime regimes and signatures. In the case of a discovery, a program is proposed to measure the underlying dynamics of the New Physics by accessing information on the mass scale, lifetimes and spin information of the new particles. This proposal evidences my qualities as a creative PI applying specialised abilities to seek out orthogonal, novel activities to push back the boundaries of science.
CONVERSION OF DILUTED MIXED URBAN BIO-WASTES INTO SUSTAINABLE MATERIALS AND PRODUCTS IN FLEXIBLE PURPLE PHOTOBIOREFINERIES (DEEP PURPLE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Spain,Spain,Spain,Spain,Italy,Austria,France,France,Czechia,United Kingdom,Denmark,United Kingdom
Call: Find solutions to dilution, pollution and content diversity challenges to turn mixed urban bio-waste (1) into sustainable feedstock for the bio-based industry (H2020-BBI-JTI-2018, 2018)
Start date: 2019-05-01
End date: 2024-04-30
Duration (months): 60.0
Total project cost (EUR): 9506062.59
EU funding (EUR): 6983049.99
Participants: 19
Project status: SIGNED

DEEP PURPLE creates a holistic consortium to transform diluted urban bio-wastes, including mixed waste streams, organicfraction of municipal solid waste (OFMSW), wastewater (WW) and sewage sludge (SS), into feedstock for bio-industry toobtain sustainable bio-products. This revolutionary concept will be implemented in a novel Single-Site Multi-Platform Concept (Biomass, Cellulose and Biogas) to replace current polluting destructive practices with new value added concepts. The beneficial use of bio-waste is obtained by an innovative combination of optimized recovery technologies and novel solutions: the Purple Phototrophic Bacteria (PPB) PhotoBiorefinery. The use of PPB -the most versatile metabolismreported- ensures the adaption to fluctuating and diluted waste streams to support a stable and profitable production chain. Thefirst PPB PhotoBiorefinery in the EU (the biggest worldwide) will be validated in different environmental, economic, logisticand social scenarios. The concept will be implemented by end-users from four municipalities, namely Madrid (ES), Toledo (ES), and the Moravia-Silesia Region(CZ) to transform bio-wastes (OFMSW: 422 t/y, mixed waste: 438,000 m3/y) into high-added value bioproducts:fine chemicals (bio-cosmetics), fertilizers, bio-packaging and self-repairing construction materials. The marketuptake of DEEP PURPLE is facilitated by optimal logistics of bio-wastes conversion (reduction of landfilled OFMSW: 60%, WWTP, solids recovery: 71%), and bio-products quality to favor their commercialization (440 t/y). The integration of valuechains is boosted by relevant stakeholder’s participation and innovative business models, minimizing waste and maximizingbenefits (85 M€ benefits, GHG emissions savings: 11,300 tCO2eq/y in 2025). Key communities (social engagementstrategies) will participate in the new value creation, calibrating the returns of the project like social innovation promotion and creation of new opportunities along the urban value cycle.

Keywords: photobiorefinery,biopolymer,cellulose,chemical precursor,fertilizer,municipal solid waste,organic fraction,phosphorous,sewage,wastewater
A multilinear approach to the restriction problem with applications to geometric measure theory, the Schrödinger equation and inverse problems (RESTRICTIONAPP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-10-02
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

The Fourier restriction conjecture, one of main open problems in harmonic analysis, has deep connections with problems in a variety of different fields of mathematics. The aim of this proposal is to further develop the multilinear approach in restriction theory and apply it to several problems in geometric measure theory, the Schrödinger equation and inverse problems. In order to develop this proposal, the Experienced Researcher will join the harmonic analysis group at ICMAT under the supervision of one of its permanent researchers, Keith Rogers, an ERC grant awardee. The host group has extensive experience in the application of harmonic analysis techniques to inverse problems and geometric measure theory, among others. The scientific training strategy of this proposal consists in the assimilation of the techniques of geometric measure theory and inverse problems. While the Researcher is experienced in restriction theory and dispersive equations, as evidenced by his contributions to the field, it is the combination of this prior knowledge with the proposed scientific training that is needed for the successful development of this proposal. This MSC fellowship will achieve a variety of positive outcomes: boosting the convergence of distinct research fields and collaborative networks, producing a synergy with the ERC Starting Grant recently held by the Supervisor, and diversifying the fellow’s mathematical knowledge, ultimately strengthening him as an independent researcher.

Keywords: fourier restriction,kakeya problem,geometric measure theory,inverse problems,schr dinger equation,carleson problem,falconer problem,calder n problem
Probing the Active Fraction of Biocrust Microbiomes in the Face of Climate Change (MICROBIOCLIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: SIGNED

Biocrusts are topsoil microbial communities that live in close association with soil particles and constitute the living skin of drylands. They intercede in numerous key ecosystem processes that are essential to desert ecosystems and play a relevant role in the global carbon cycle. Despite their inherent tolerance to aridity, a growing body of literature suggests that forecasted alterations in precipitation patterns, a global imprint of climate change, has the potential to dramatically affect these communities. However, little is known about how this will alter biocrust microbiome functioning and how these changes will be echoed to the soil properties and carbon budget in global drylands. This lack of knowledge arises from the difficulty to reliably link culture independent traditional genomic data to soil function. Thus, there is an urgent need to implement techniques that allow the identification of active organisms driving soil processes. The main objective of MICROBIOCLIM is to gain a deeper insight into the effect of altered precipitation patterns driven by climate change on biocrust microbiome functioning in drylands. To tackle this objective, MICROBIOCLIM will implement Biorthogonal Non-Canonical Amino Acid Tagging (BONCAT) coupled to omics methods to probe active cells in situ in biocrust while tracking the evolution of the soil carbon budget under climate change scenarios. The research outlined here includes multiple spatial and temporal scales, which will allow us to gain critical knowledge to design strategies to preserve biocrusts and the ecosystem services they render. This project will also help fill a major gap in our understanding of the underlying mechanisms controlling soil respiration and their implications for carbon cycling in global drylands, both priorities of the H2020 and the EU Green Deal.

Keywords: biocrusts,microbiome,climate change,molecular ecology,soil functionality,respiration,drylands
Fast track development of a Zika vaccine based on measles vector (ZIKAVAX)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,France
Call: Vaccine development for malaria and/or neglected infectious diseases (H2020-SC1-2016-RTD, 2016)
Start date: 2016-10-01
End date: 2020-12-31
Duration (months): 51.0
Total project cost (EUR): 4918137.5
EU funding (EUR): 4918137.5
Participants: 4
Project status: CLOSED

Zika virus is an emerging mosquito-borne flavivirus. Although already isolated in 1947, to date there are no specific treatments nor any vaccines available against Zika virus disease, making it a truly neglected infectious disease. The recent rapid spread of the Zika virus in previously unaffected regions has provided strong epidemiological evidence that infection with this virus might be associated with neurological complications in adults and with an increase in severe congenital brain malformations of new-borns. Consequently, the World Health Organization has declared the recent outbreak of the Zika virus a public health emergency. The ZIKAVAX proposal has the objective to address this urgent public health issue by promoting the rapid development of a safe, effective, and affordable preventive vaccine against Zika virus infection. To achieve this goal, ZIKAVAX will use a delivery platform technology based on a measles vaccine vector with demonstrated proof of principle in humans and a preclinical track record of rapid adaptability and effectiveness for a variety of pathogens. The manufacturing process for these measles vector-based vaccines has been developed to give high yield and purity using standard equipment. In ZIKAVAX, following antigen selection and expression, immunisation studies will be conducted with the Zika vaccine candidate in mice and in a challenge model in non-human primates that will developed by the consortium. The ultimate goal of ZIKAVAX is the demonstration of safety and immunogenicity of a recombinant measles-Zika vaccine candidate in adult volunteers in a phase Ia clinical trial. ZIKAVAX is driven by a strongly committed and effective consortium of four leading European organisations highly experienced in vaccine research and development. Its partners include the European Vaccine Initiative, Institut Pasteur, Themis Bioscience GmbH and the Institute of Emerging Diseases and Innovative Therapies from the Commissariat à l’Energie Atomique.

Keywords: zika,neglected infectious disease
Laboratory Experiments on Magnetic Phenomena in Geo- and Astrophysics (LEMAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 2493250.0
EU funding (EUR): 2493250.0
Participants: 1
Project status: SIGNED

Cosmic magnetic fields, including those of planets, stars, and galaxies, are being generated by the homogenous dynamo effect in flowing electrically conducting fluids. Once produced, these fields may play an active role in cosmic structure formation by fostering angular momentum transport and mass accretion onto central objects, like protostars or black holes, by means of the magnetorotational instability (MRI). Complementary to the decades-long theoretical research into both effects, the last years have seen great progress in respective experimental investigations. The dynamo effect had been verified in three liquid sodium experiments in Riga, Karlsruhe and Cadarache. The helical and the azimuthal versions of the MRI, as well as the current-driven Tayler instability (TI), were demonstrated at Helmholtz-Zentrum Dresden - Rossendorf (HZDR). Here, I propose to make three further breakthroughs in this research field. First, I plan to demonstrate dynamo action based on a precession driven flow of liquid sodium in a cylindrical vessel. Besides thermal and compositional buoyancy, precession has been discussed as a complementary power source of the dynamos of the Earth, the ancient Moon, and other cosmic bodies. A second experiment will deal with magnetically triggered flow instabilities of astrophysical importance, with the main focus on attaining standard MRI, and various combinations of MRI and TI. Both experiments will be carried out at the DRESDYN facility at HZDR which has been conceived by me and which will enter into operation in 2019. In contrast to these well-advanced experimental concepts, my third liquid sodium experiment, which aims at showing the magnetic destabilization of rotating flows with radially increasing angular velocity, still requires more numerical simulations and design engineering. Given the comparatively less demanding technical parameters of this set-up, I expect first experimental results within the funding period, too.

Keywords: magnetohydrodynamics,dynamo experiments,accretion disks,instabilities
Development and Testing of a Reference Computational Platform for Understanding Biomolecular Recognition (UBioRec)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Due to its fundamental regulatory role, molecular recognition has been extensively studied by both experiments and simulations. During the last 30 years impressive technical advances allowed significant progress in understanding molecular recognition mechanisms. However, the matter is far from settled and contradictory reports are still appearing in the literature. Lately, I have been studying these processes using a combination of computational and experimental approaches in different systems. Here I propose to study several representative model systems in great details, taking advantages of new force fields, DFT functionals and enhanced sampling algorithms recently emerged. These systems are small enough to allow the use of state-of-the-art simulation techniques; still they are sufficiently complex not only to mimic the behaviour of far larger systems but also to use apparently different mechanisms. Indeed, their molecular recognition needs complex conformational changes, the re-arrangement of water molecules in the binding cavity, and an active role of the ligand in the binding/release mechanisms. The overarching objective of my proposal is to learn the state-of-the-art enhanced sampling techniques developed at UCL and combine them with QM/MM approaches to: i) understand how bio-molecular recognition works in both isoforms, ii) fully characterize the thermodynamics and kinetic processes that govern them and iii) validate the computational approaches against high-quality experimental data. If successful, the in-depth understanding of the molecular binding mechanism will shed light on an intriguing and important biological system and provide a much needed benchmark to the computational community. This challenging but feasible project will have a far reaching impact on a number of H2020 priority areas, including drug discovery and bio-molecular engineering.

Keywords: molecular dynamics simulations,free energy calculations,molecular recognition,drug design,biomolecular simulations,multi scale approaches
Periconceptional Programming of Health Training Network (DohART-NET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Spain,Germany,Switzerland,Belgium,Hungary,China,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-07-01
End date: 2023-11-30
Duration (months): 53.0
Total project cost (EUR): 3398005.68
EU funding (EUR): 3398005.6799999997
Participants: 20
Project status: SIGNED

Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (‘Developmental Origins of Health and Disease (DOHaD) concept). Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise. Babies born following human ART (“testtube”)interventions render this population (over 5 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe. The DohART-NET project focus on the integration of pre-clinical (animal and stem cell-models) and clinical studies and apply data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. We will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways. DohART-NET is optimized for training ESRs due to the facts that: i) the topic is progressive and much needed to improve public health over several generations, and it is integrating basic pre-clinical, translational clinical and in silico modeling approaches, iii) the partnership has a highly multi- and interdisciplinary scientific and training expertise and excellence, iv) there is an existing synergy by collaborations and links that the partners wish to strengthen both in science and lasting training programs in a highly inter-sectorial setting.

Keywords: human art,embryology,patient cohort,dohad,diabetic mother,animal models,stem cell model,epigenetics,proteomics,transcriptomics,metabolomics,bioinformatics,network science