Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From oculomotor action to perception (ProactionPerception)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-07-21
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The proposed scientific project addresses a gap in our current knowledge in neuroscience linking sensory physiology and motor behavior to active perception. Animals disambiguate between motion in the environment and self-movement using corollary discharge, proprioceptive signals and reafferent sensory input. These signals can also be used to influence information acquisition to optimize sensory processing. I plan to explore the links between oculomotor action and perception during proactive exploration of a visual scene to understand how eye movements reshape processing in the early visual system. Because humans are largely ‘visuals animals’ ‘active vision’ is of primary importance to our behavior in our everyday lives. A better knowledge of this phenomenon is relevant to improved understanding of the visual system but will also be relevant to the study of all sensory systems and to a deeper understanding of information processing algorithms, including the value of internal predictive paradigms used throughout the brain. The project has translational potential for the fields of medicine and neural prosthetics, neuromorphic computing, and robotics. This project combines my previous knowledge in cognitive neuroscience and eye movements, acquired during my 6.5 year stay in the USA with the host laboratory’s expertise in low level synaptic system neuroscience. It therefore ensures both acquisition and transfer of new knowledge and opens opportunities of new collaborations. The MSCA Reintegration Fellowship will furthermore give me the opportunity to fully reintegrate in Europe and significantly widen my competences with the ultimate goal of providing the best career possibilities, enhancing the creative and innovative potential, to maximize the contribution of research to the knowledge-based economy and society.

Keywords: neuroscience,visual perception,perception action,intracellular electrophy,eye movements and visual reafference,dynamic perceptual filtering,intra v1 horizontal binding
A holistic water ecosystem for digitisation of urban water sector (NAIADES)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Germany,Spain,Estonia,Ireland,Romania,Belgium,Romania,Switzerland,Switzerland,Greece,Slovenia,Greece,Netherlands
Call: Digital solutions for water: linking the physical and digital world for water solutions (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 5683253.75
EU funding (EUR): 4999980.13
Participants: 19
Project status: CLOSED

NAIADES Ecosystem envisions transforming water sector through automated and smarter water resource management and environmental monitoring, achieving a high level of water services in both residential or commercial consumers, exploiting the efficient use of physical and digital components of water ecosystem. NAIADES will apply in various situations on diverse big data in terms of sources, data types, and entities represented that is collected by such water monitoring and control systems in Europe, including (i) the water consumption in both retail and corporation efficiency, (ii) the confidence of water consumers (including special groups as ageing, disabled persons and children), by measuring the water quality in residential buildings, offices and public infrastructures (mall, hospital), (iii) the safety and reliability through the detection of warning signs from equipment failures and maintenance report, and (iv) personalized persuasive feedback and recommendation services provided to the NAIADES App Users aiming to enhance public awareness on water consumption and usage savings, and promote user engagement in water conservation activities. NAIADES AI elements, aim to provide multidimensional intelligence on the water ecosystem by introducing: Situational Intelligence - by collecting real-time data from the buildings as they are in operation and analysing it in three different dimensions; Spatial, Temporal and Nodal; Operational intelligence - by using the power of data and its capability to extract the right information at the right time to provide insight into water infrastructure operation and improve the effectiveness of maintenance activities; Asset intelligence: the continuous data streams produced from various sub-systems in buildings will help OEMs build digital twins that represent physical systems in real-time. NAIADES ecosystem will be validated and demostrated in three heterogeneous pilot sites.

Keywords: artificial intelligence,deep learning models,machine learning,consumer behavior monitoring
Peripheral nerve Gel-based Orientation (Peripheral nerve injury recovery using Gel-based Orientation) (PeriGO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 120000.0
Participants: 2
Project status: CLOSED

PeriGO will pave the way for the commercialization of a unique, first-of-its-kind peripheral nerve repair strategy, as it uses an injectable, biocompatible hydrogel that provides directionality through controlled guiding elements. The properties of the smart material Anisogel, initially developed in the ERC project ANISOGEL to repair spinal cord injuries, provide a sophisticated, superior alternative for peripheral nerve regeneration. The final product can be injected inside a bridging blood vessel or artificial hollow tube after implantation to direct regenerating nerves across the injury site. PeriGO comprises 3 key actions to advance a quick translation from the laboratory to the clinic: We will 1) establish a sterilization method and a packaging/application system to perform pre-clinical tests, 2) verify the handling and efficacy of the product in a rat sciatic nerve lesion model in cooperation with the Department of Plastic Surgery at the University Hospital in Aachen, and 3) complete a market study and business plan to bring PeriGO into the clinic. PeriGO addresses essential issues associated with peripheral nerve regeneration. While the current Gold Standard of autologous nerve grafts creates a secondary defect, artificial bridging approaches for nerve gaps only reconnect short distances (< 3 cm) with marginal success. Features absent in the commercially available nerve tubes are guiding structures, controlled degradation, and a good interface with the damaged nerve stumps. The PeriGO platform will overcome these limitations as the material 1) is injected as a liquid to make a tight contact with the injured nerve and to adapt to the shape of the bridging tube before gelation, 2) provides unidirectional guiding elements, and 3) presents tunable material properties with tunable degradation kinetics adjusting to the length of the nerve gap. With PeriGO, we will thus establish the next generation of nerve repair strategies.

Keywords: peripheral nerve repair,medical device,injectable hydrogel,unidirectional guidance,commercialization next generation nerve regeneration therapy
Driving decarbonization of the EU building stock by enhancing a consumer centred and locally based circular renovation process (DRIVE 0)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Estonia,Ireland,Italy,Italy,Spain,Spain,Belgium,Greece,Slovenia,Slovenia,Netherlands,Netherlands,Netherlands,Netherlands
Call: Decarbonisation of the EU building stock: innovative approaches and affordable solutions changing the market for buildings renovation (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-10-01
End date: 2023-12-31
Duration (months): 51.0
Total project cost (EUR): 4819143.75
EU funding (EUR): 3999505.63
Participants: 22
Project status: SIGNED

DRIVE 0 aims to come to a decarbonization of the EU building stock and to accelerate deep renovation processes by enhancing a consumer centred circular renovation process in order to make deep renovation more attractive for consumers and investors, more environmental friendly.This by combining the need for a circular building industry with the identification of specific local or national drivers to trigger and to motivate end-users for deep renovation, supported by an anthropology based and environmentally friendly approach to make it costumer-centred and respectful of local geo-material areas, by following 4 steps: 1. Developing proven deep renovation products and concepts for example from several recent EU projects, further to circular renovation products and concepts based on local available materials and components, with emphasis on easy to install Plug & Play prefab solutions for envelope elements and building services. 2. Developing attractive consumer centred business models based on circular renovation concepts supported by digitalization and gamification. 3. Providing occupants with attractive and understandable information on total building performances in use. 4.Providing stakeholders evidence of performance of the developed solutions by local study and demonstration cases initiated by ‘local drivers’. The objectives are: 1: To develop proven Plug & Play prefab deep renovation solutions for building elements and building services towards circular renovation products. 2: To provide consumers and potential investors of deep renovation projects with attractive and understandable information of real total performances (energy use, indoor environment and well-being). 3: To demonstrate circular renovation solutions in combination with local drivers in live demonstration cases. 4: To foster new consumer centred business models for circular circular renovation concepts. 5: To roll out the concept on a wider EU scale by involving EU interest groups.

Keywords: circular renovation
Nuclear Regulators of Fungal Enzymes (NURoFE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-05-26
End date: 2023-05-25
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: CLOSED

The dependence of mankind on petroleum- and oil-based fuels as the main energy source is widely recognised as being accompanied by several problems that impact the global economy and environmental health. In recent years, the conversion of plant biomass to biofuels, in a process called 1st- (1G) and 2nd-generation (2G) biofuel-production, has gained significant interest as an environmentally friendly and naturally abundant alternative, renewable energy source. The EU (European Union) legislation implements that by 2020, 20% of energy must be derived from renewable sources, showing the importance that renewable energy source production will play in the future. Saprobic microorganisms, such as filamentous fungi of the genus Aspergillus, are of particular interest for this process as they secrete a vast array of plant biomass hydrolyzing enzymes. A major drawback in the production of renewable biofuels is built-up of glucose during enzymatic hydrolysis of plant biomass, resulting in the transcriptional repression of fungal enzyme-encoding genes and subsequent secretion. The here described fellowship is proposing to uncover novel proteins involved in the regulation of hydrolytic enzymes and secondary metabolites production in the filamentous fungus Aspergillus nidulans that can be explored for biotechnological processes. To implement this project, the candidate will be hosted at the National University of Ireland in Maynooth in the laboratory of Fungal Genetics and Secondary Metabolism, under the supervision of Dr. Ozgur Bayram.

Keywords: biofuels,aspergillus,metabolism,enzymes,xylanases,cellulases,secondary metabolites
EggXYt: A novel approach for sexing chicken embryos on day one before incubation - saving them from being hatched and disposed. (eggXYt)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Israel
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-03-01
End date: 2017-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the layer industry, chicks are culled (culling is the process of killing newly hatched poultry for which the industry has no use) by billions on an annually basis via suffocation or grinding or even more cruel methods. The males are terminated since they are not useful for laying eggs or to be bread for meat and the weak or unhealthy females are being terminated as well. Thus, more than 7 billion male chicks are killed on day of hatching generating an annual loss of ~1 Billion Dollars (cost of unnecessary hatching, human employees as sexers and waste management) ,associated carbon emissions, ethical and environmental impacts. Clearly a method for in-ovo, or embryo sex-determination prior to hatching (incubation) is thus highly desired due to both ethical and economic considerations. Our added value: We have developed a patented method –using cutting edge technologies in biology and optics - to detect the sex of the 1 day embryo immediately after being laid and before entering the 21 day incubation process. In other words, we are developing the morning after pill for chicks!!! This way, our clients - hatcheries (and practically the whole industry) are saving money, they will not need to deal with chick culling and can use the unhatched male containing eggs in secondary markets where eggs are used as an ingredient (e.g. pharma, pastry etc.). We are bringing a novel approach that contributes to i) Saving over 7 billion chick lives annually ii) Saving the industry ~ 1 Billion dollars annually and iii) adding over 7 billion eggs to the global food supply.

Keywords: sexing chicken,hatch,innovation
Contactless, Multidimensional Sleep Monitoring and Assessment Solution (Sleepiz)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sleep loss is an aggravating factor in the global burden of disease with collateral effects on cardiovascular and mental health as well as injury and death through human error. State of the art clinical diagnostic tools that measure sleep data are expensive, complex to interpret, and stressful for the patients. Today’s most accurate diagnostic tools require patients to strap electrodes and chest monitors to their body and undergo overnight testing, often in a clinic. Sleepiz AG has developed a breakthrough solution in clinical sleep-monitoring solutions. Our innovation, Sleepiz, is a contact-free sensor-based diagnostic device for sleep specialists and clinics. It can analyze patients’ vital signs and environmental measurements without touching the patient. We use test results to continuously feed and improve our self-learning algorithms. Sleep specialists will prescribe Sleepiz to patients to use in their homes. Doctors can view the results remotely and in real-time. We will charge clinics a fee per session in line with today’s diagnostic costs; our solution will be up to 2x more time- and cost-efficient. The approval of Sleepiz as a clinical diagnostic device in the EU and US, together with the ramp-up of commercial activities and stakeholder outreach, comprise the major objectives of this project. The goal of phase 1 is to further validate product-market fits, along with planning and allocating resources for clinical validation trials during phase 2. Sleepiz AG is a Swiss startup comprised of young entrepreneurs and innovators. We have already created great interest: 4 hospitals that use clinical-grade sleep diagnosis tools - a market worth close to €5Bn – want to validate our system. An advisory board of leading experts in related tech and innovation fields will help guide our go-to-market plan. We project annual sales revenues of €34.16M by year 5 after market launch, and we forecast directly creating 197 jobs.
Remote control healing: Next generation mechano-nano-therapeutics (DYNACEUTICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2499068.0
EU funding (EUR): 2499068.0
Participants: 1
Project status: SIGNED

Imagine if doctors could heal patients via remote control. Following simple injections into regions of the body, they could activate internal cells by an external bandage. In this way, they could remotely control the ways tissue heal. This Advanced grant sets out to understand, design and develop the mechano-nano-magnetic platform that will underpin this therapeutic strategy for the future – DYNACEUTICS. Key receptors have been identified such as ion channels, integrins and growth factors which respond to mechanical cues on the membrane and activate downstream pathways. How do we ‘bottle’ an agonist like a drug which can influence or regulate mechano-sensors on the membrane and can be controlled remotely? This project tackles this complex interdisciplinary question through breakthrough nanotechnologies. We aim to expand and develop a platform technology using magnetic particle tagging which will allow us to direct cells for therapeutic purposes. Specifically, we aim • to identify mechano-receptor binding sites on stem and mature cells which will enable remote activation of signalling pathways via magnetic fields, • to design and test magnetic particles with tailored tagging strategies using single cell through 3D human organoid models to in vivo disease models, • to tailor and design external remote control devices • to create clinically relevant treatment modalities for remote control healing. This proposal presents a unique opportunity to launch a new dynamic treatment platform, DYNACEUTICS, which we propose will extend the therapeutic horizon and provide a new form of remote controlled healing.
Quantum Mechanics in the Negative Mass Reference Frame (QUANTUM-N)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Denmark
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-07-01
End date: 2023-06-30
Duration (months): 60.0
Total project cost (EUR): 2178574.0
EU funding (EUR): 2178574.0
Participants: 1
Project status: SIGNED

A fundamental aspect of quantum mechanics is the balance between information and disturbance by the measurement. A textbook example is the measurement of a position of an object which imposes a random perturbation on its momentum. This perturbation, the quantum back action, translates with time into uncertainty of the motion trajectory. The PI has proposed an approach which allows for simultaneous measurements of arbitrary small disturbances in both the position and the momentum. It is based on a measurement performed in a quantum reference frame with an effective negative mass, or frequency for an oscillator. Recently the PI’s group has experimentally demonstrated the first step along this novel path - quantum back action evasion for the measurement of motion in a reference frame of a spin oscillator. We propose a project which takes detection of motion to a new frontier. We will develop a novel hybrid quantum system involving disparate macroscopic objects, a mechanical oscillator and a reference spin oscillator with the effective negative mass. We will demonstrate quantum entanglement between the two oscillators and entanglement-enhanced sensing of force and acceleration. The technology for high quality mechanical and spin oscillators developed at the PI’s group will be further advanced towards those goals. We will generate manifestly non-classical states of millimetre size mechanical oscillators and a macroscopic coherent superposition of distant spin and mechanical objects. We will furthermore work towards generation of multi-partite entangled states of spins, macroscopic objects, and photons, thus testing fundamental limits of entanglement and decoherence for large and complex systems. Gravitational wave interferometers which have recently detected first gravitational waves are expected to be soon limited in their sensitivity by the quantum back action. The way to overcome this limit using the approach developed within this project will be explored.

Keywords: quantum entanglement,hybrid quantum systems,sensing beyond standard quantum limit,atomic spin ensembles,quantum optomechanics,quantum measurement