Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The virtual sound platform of the future (Treble)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Iceland
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-06-30
Duration (months): 18.0
Total project cost (EUR): 4310000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Today, it is challenging to simulate how products – cars, audio equipment, buildings, wind turbines, hearing aids, etc – will sound. The same limitation applies to simulating and rendering sound for virtual spaces, i.e., virtual reality, metaverse, video games and augmented reality. We have developed a disruptive sound simulation technology based on an entirely new paradigm (“wave-based” methods versus traditional “ray tracing” methods). This technology opens a vast array of new opportunities in engineering design and metaverse applications. We offer a ground-breaking cloud-based sound simulation software platform with a cutting-edge proprietary simulation technology at its core with two main capabilities: • Sound simulation: Predict, design and optimise how products & buildings will sound. • Sound rendering: Generate authentic sound in a virtual domain. The technology is 100-1000x faster than current technologies, resulting in a complete paradigm shift in sound simulation.

Keywords: signal processing,spatial audio,computational mathematics,high performance computing,architectural acoustics,dev ops,cloud computing,sound simulation technology,machine learning,gaming audio,audio reproduction,virtual acoustics,sound rendering,,wave based methods,engineering acoustics,bim solutions
The health benefits of deuterium depletion on synaptic function, regional metabolism, and behaviour (Aqua-Synapse)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal,Germany,Hungary,United Kingdom,Italy
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 885828.57
EU funding (EUR): 763600.0
Participants: 8
Project status: SIGNED

Core idea of this project is to establish the mechanistic basis for the positive health effects of deuterium depleted water and determine what regimens are most efficacious. Isotope content of drinking water has been shown affect the pathogenesis of cancers to ameliorate the stress response and reduce susceptibility to many diseases, but it remains unclear how the positive biological effects of heavy isotope reduction in drinking water are mediated. High concentrations of deuterium induce mitochondrial dysfunction, and very high concentrations can induce cell death, but the administration of deuterium at 91 ppm has antidepressant effects that were comparable to that of citalopram in a mouse model of depression. Use of deuterium depleted water appears to represent a safe intervention with few, if any, reported side effects, but it remains unclear at what concentrations the positive metabolic and behavioral effects become apparent. Companies in Europe now sell DDW at different concentrations to the public amidst a plethora of health claims that mostly lack in any sound scientific basis or safety data Thus, there is an urgent need to better understand the impact of DDW on brain and behavior at a molecular level. We will use state-of-the art imaging techniques to measure regional metabolic fluxes in the body of animals in healthy individuals throughout life and those subject to stress following the administration of DDW at different concentrations and for different periods. Also we examine how deuterium depletion affects the behaviors of neurons in vitro and electrophysiological levels and in terms of their metabolism. The project is made possible by bringing together a consortium of chemists, cell biologists, pharmacologists, imaging specialists, psychiatrists, and DDW producers for ‘medicinal needs’ in fully translational work packages to discover, in an empiric manner, how the manipulation of metabolic pathways with DDW can be employed for the benefit of human health

Keywords: deuterium content in drinking water metabolic and associated affective disorders
Flexible and hybrid manufacturing of green aluminium to produce tailored adaptive crash-tolerant structures (FLEXCRASH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Spain,Sweden,Italy,Austria,Germany,Slovenia
Call: Testing safe lightweight vehicles and improved safe human-technology interaction in the future traffic system (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 4571744.25
EU funding (EUR): 4571744.0
Participants: 12
Project status: SIGNED

Flexcrash aims to develop a flexible and hybrid manufacturing technology based on applying surface patterns by additive manufacturing onto preformed parts. Aluminium alloys have been selected as the optimum material to build high performance structures, addressing both lightweight and environmental sustainability. They provide better recyclability, affordability (low CRM content), and costs than other material alternatives that would need complex developments for joining, recycling, and manufacturing. The property tailoring capacity offered by hybrid manufacturing will permit to develop a new type of crash-tolerant structures with outstanding performance under a wide range of impact angles and unexpected crash conditions. Structures will be defined according to the collision parameters identified by the different mixed traffic scenarios. Such tailored structures are the ideal solutions for dynamic active safety devices that allows displacement of crash structures to optimally face an imminent crash. Considering that the frontal crash is the most common (70%), a front-end structure has been chosen as demonstrator to validate the manufacturing developments, the modelling approach and the testing methodologies. The flexibility of the proposed technology will facilitate its transferability to other safety-related structures in vehicle’s locations with higher risk for passenger’s injuries while decreasing the number of materials and processes used to manufacture a crash structure. Simplify supply chain will turn into 20% manufacturing costs saving and reduce the risk of disruption. Virtual testing with improved reliability, validated by crash tests, will be used to propose new testing configurations, looking at the next step towards standardization. The application of Flexcrash solutions to the whole BiW offers a lightweighting potential up to 20% with improved safety (toward 50% reduction of passenger’s injuries and fatalities).

Keywords: hybrid manufacturing,additive manufacturing,aluminium alloys,extruded profiles,casting,virtual testing,crashworthiness,toughness,durability,material models,traffic modelling
From single cells to microbial consortia: bridging the gaps between synthetic circuit design and emerging dynamics of heterogeneous populations (BridgingScales)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1497790.0
EU funding (EUR): 1497790.0
Participants: 1
Project status: SIGNED

A key turning point in the evolution of life was the transition from single-cell to multicellular organisms and the optimization of fitness via division of labour and specialization. Similarly, microorganisms have evolved equivalent strategies by forming communities or consortia. Division of labour in isogenic microbial populations is often implemented by mechanisms that create or act upon population heterogeneity to diversify functionality. Rational design in synthetic biology, on the other hand, is focused on the engineering of gene circuits with deterministically predictable functionality within single cells. While synthetic biology has certainly come a long way, predictable functionality of circuits in growing microbial populations still remains elusive or limited to tightly constrained operating conditions. We will develop novel mathematical methods to characterize and control the dynamics of synthetic gene circuits within growing microbial populations. We will develop a modelling framework and novel computational methods that take both stochasticity of single-cell processes and consequences of heterogeneity for population dynamics into account. On the mathematical side, this necessitates coupling single-cell stochastic processes to state dependent population processes such as growth or selection. We will develop methods for parameter inference, experimental design and control for such models. This will enable the construction of models that can be used to design synthetic circuits that function as specified within growing populations and that can be deployed to regulate single-cell processes such that desirable dynamics emerge at the scale of populations and consortia. We will apply the methodology for bioproduction problems in which proteins that are hard to fold need to be produced. Overproducing such proteins impairs cellular growth, which creates couplings between single-cell and population processes and raises the need to feedback control production.

Keywords: stochastic chemical kinetics,continuous time markov chains,parameter inference,optimal experimental design,population dynamics,optogenetics,synthetic biology,cybergenetics
Multi-sensory solutions for increasing human-building resilience in face of climate change (MuSIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Italy,Cyprus,France,Denmark,Netherlands,Serbia,Spain,Belgium
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 2729945.83
EU funding (EUR): 2655820.8
Participants: 11
Project status: SIGNED

Climate change is leading to more frequent and severe extreme climate phenomena, affecting both vulnerable subpopulations like children, the elderly and the poor, and healthy and well-being people. To increase human-building resilience against climate change, active building solutions are often sought and promoted, however, they require a substantial energy use and thereby generate further environmental impact and/or lead to adverse effects like increased noise or pollutions. Also, these solutions protect from exposures rather than actually increasing human resilience. On the contrary, passive and hybrid solutions do not contribute significantly to greenhouse gas emissions but are often regarded as less robust and predictable and are affected by design challenges and potential rebound effects. For example, increased use of solar shading may affect lighting requirements, and night-time ventilation may influence indoor noise levels. With this multi-disciplinary multi-sectoral MSCA doctoral network, MuSIC will address these challenges within the context of the existing European building stock and will provide solutions from the human-centred viewpoint. 5 academic and 1 non-academic beneficiaries together with 2 academic and 3 non-academic associated partners will strive for educating the next generation of highly qualified young professionals able to provide future generations with more liveable and sustainable indoor and outdoor spaces in and management systems of cities by applying cutting-edge solutions, multi-sensory and multi-dimensional research and industrial development. 10 early-stage researchers will experience interdisciplinary and intersectoral training modules on science and technology as well as transferable skills and conduct individual R&D projects for improved understanding and predictability of human reactions and innovative human-centric building- and community-related solutions for increasing human-building resilience in the face of climate change.
Motivic Stable Homotopy Theory: a New Foundation and a Bridge to p-Adic and Complex Geometry (MOSHOT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1470201.0
EU funding (EUR): 1470201.0
Participants: 1
Project status: SIGNED

This project is centered on the field of algebraic geometry and involves homotopy theory and analytic geometry. The overall goal is to unveil the underlying principles of a large variety of cohomology theories in algebraic and analytic geometry and develop robust foundations that facilitate the study of those cohomology theories from the vantage point of homotopy theory. This will be achieved through innovations of motivic stable homotopy theory beyond the current technical limitations of A1-homotopy invariance. In addition, its interdisciplinary perspective will be advanced, especially in relation to p-adic geometry and complex geometry. The research proposal consists of 5 main objectives, which are organically related to each other. The first objective is to establish a six functor formalism, which would be the most important challenge in non-A1-invariant motivic stable homotopy theory. The second objective is to investigate the kernel of the A1-localization and aims to describe it in terms of p-adic or rational Hodge realization, following the principle of trace methods of algebraic K-theory. In particular, in the p-adic context, this will lead to the p-adic rigidity, which will conclusively connect motivic homotopy theory with p-adic geometry. The third objective is to find out the potential of unstable motivic homotopy theory and develop calculation techniques. The forth objective is to establish a general and universal construction of motivic filtration of localizing invariants, such as algebraic K-theory and topological cyclic homology. The last objective is to explore the analogue in complex geometry, which is an interesting unexplored subject that will pave the way for further developments of motivic homotopy theory for a broader range of analytic geometry.
GRAPH reconstruction, COspectrality and SYnchronisation through the lens of number theory, geometry and algorithms (GRAPHCOSY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Graph theory is a field with many beautiful and powerful connections to other areas of mathematics and computer science. In this project, the experienced researcher (ER), an expert in graph theory, will further explore these connections together with the experts in number theory, manifold and parameterised complexity from the host. Moreover, solving the chosen problems will improve our understanding of several famous open problems. - Graph reconstruction (WP1): does local information of the graph (e.g. subgraph counts) determine graph invariants (e.g. the number of spanning trees)? The ER will continue her excellent track record in this area with the help of the number theoretical expertise of the host. - Graph isomorphism (WP2): study small common covers of pairs of graphs, building up to the computation of a set of matrices whose spectra determine whether the graphs are isomorphic. This package carries concepts and techniques within the expertise of the supervisor to graph theory, opening up a new avenue of research. - Černý's conjecture (WP3): probabilistic and parameterised complexity aspects are studied of the question `How long is the shortest reset word in a given finite state automaton?'. This combines the expertise of the ER in extremal and probabilistic combinatorics with the expertise in parameterised complexity of the host.

Keywords: graph reconstruction,graph polynomial,common cover,graph cospectrality,finite state automaton,reset word,parameterized complexity
Low capillary number flow in phase change porous media: permeability and liquid water capacity of snow. (SnowMagnet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 307939.68
EU funding (EUR): 307939.68
Participants: 2
Project status: SIGNED

The effective hydraulic conductivity of snow is highly impacted by its microstructure, introducing a variability of at least three orders of magnitude, impacting seasonal flooding and glacier hydrology. Yet, the mechanisms of unsaturated flow and the impact of local phase transitions have never been investigated at the pore scale. This inhibits improving on the constitutive laws for larger scale models of snow hydrology using upscaling methods. Micro computer tomography is a very effective method for dry snow metamorphism but fails for wet snow because the transient flow and the accelerated change in microstructure cannot be resolved. We propose nuclear magnetic resonance (NMR) methods in combination with Lattice-Boltzmann simulations and Pore-Network models to characterize water flow in snow. Applying these methods on unsaturated flow in snow, we can resolve local saturation, liquid water displacement probabilities and diffusion measures, quantitatively measuring mechanisms of water transport. These are essential for gauging modelling approaches of transport phenomena. Whilst NMR methods have been used extensively on saturated flow, it has found limited application in unsaturated media and is poised for significant advances. To target melt and percolation phenomena in snow, we start with 3D printed porous media (single pores and fully resolved snow geometries) to refine the experimental setup and provide novel data for unsaturated flow in porous media. Assisted by Lattice-Boltzmann simulations we can link pore-scale mechanisms to the NMR data. The action will produce unique data sets on unsaturated flow as a function of capillary number in model porous media and snow. This data will be used to calibrate dynamic pore network models aiming at quantifying the transient flow in snow. This leads to a parameterization of effective hydraulic conductivity for a wide range of snow microstructures providing a new standard for models resolving water transport in snow.

Keywords: snow melt,pore scale dynamics,transport in porous media,phase transitions,percolation,hydraulic conductivity,nuclear magnetic resonance,lattice boltzmann simulations,pore network models
Protein glycosylation in gene-edited T cells combating IgA Nephropathy (geneTIGA- Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Croatia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 28.0
Total project cost (EUR): 656875.0
EU funding (EUR): 656875.0
Participants: 2
Project status: SIGNED

Glycosylation is the most elaborate post-translational modification of proteins that significantly affects their structural and functional. Immunoglobulin A (IgA) contains highly complex glycosylation and it is known that defect in IgA glycosylation plays an important role in the development of IgA nephrophathy (IgAN). However, the comprehensive analysis of IgA glycosylation has not been systematically performed in a larger number of individuals, neither in the general population nor in individuals with IgAN. Furthermore, the regulation of IgA glycosylation and its impact on IgA function remain poorly understood. Genos, the proposed widening partner, is the global leader in high-throughput glycomics that generated glycomic data for numerous large clinical and epidemiological studies. Researchers in Genos made significant contributions to the understand the role of immunoglobulin glycosylation in a number of inflammatory disease. Recently Genos researchers developed a high-throughput method for analysis of IgA glycosylation at both released glycans and the glycopeptide level. By including Genos as a widening partner in the project, the geneTIGA project's objectives will be further enhanced through the integration of IgA glycomics with other analyses and approaches conducted within the geneTIGA project.

Keywords: glycomics,iga glycosylation,iga nephrophaty