Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Wnt Enhancer LandscapE CharacTerization (WntELECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Despite significant efforts, cancer remains one of the major health challenges in Europe. In essence, cancer can be seen as the result of alterations in the intricate balance between cell proliferation, differentiation and death during tissue homeostasis. Hence, pathways that are essential for the development and maintenance of mammalian tissues are frequently deregulated in human tumors and represent attractive targets for therapeutic intervention. In that respect, the Wnt signal transduction pathway serves as a paradigm: On the one hand, Wnt ligands are crucial determinants of cell fate decisions and can act as self-renewal factors for adult stem cells in multiple tissues, including the mammary gland. On the other hand, aberrant activation of the Wnt/beta-catenin pathway is a hallmark of many human (breast) tumors. While it is clear that Wnt activity has to be carefully coordinated in precise temporal and tissue-specific patterns, there is a significant knowledge gap regarding the underlying control mechanisms. In this project, I will combine bioinformatics, state-of-the-art genome engineering and an innovative screening approach to identify Wnt-associated enhancers in the mammary gland. I aim to: 1. Establish an effective experimental pipeline for an epigenetic screen. 2. Identify functional regulatory sequences for almost half of the mammalian Wnt genes. 3. Validate individual enhancers in vivo. The proposed research together with the training I will receive in an excellent, multidisciplinary research environment will significantly benefit my scientific career development. Finally, I envisage that my results will provide the basis for uncovering how environmental and intrinsic signals are integrated to control dynamic Wnt expression patterns in both normal development and cancer.

Keywords: wnt signal transduction,enhancer,crispr,cas9,functional screen
Lossless Photon management – Optical design for manufacture at different length scales (NOLOSS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Germany,Italy,Germany,Switzerland,Finland,Switzerland,Netherlands,Netherlands,Netherlands
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-04-01
End date: 2020-03-31
Duration (months): 48.0
Total project cost (EUR): 3828390.55
EU funding (EUR): 3828390.55
Participants: 13
Project status: CLOSED

The target of this project is to prepare and train future engineers for the design challenges and opportunities provided by modern optics technology. Such challenges include lossless photon management, modelling at the system, components and feature level, and the link between design and technology. Today all optical designs are often perceived following different approaches, namely geometrical optics, physical optics and nano-photonics. Traditionally these approaches are linked to the different lengths-scale that are important to the system. Starting from the entire system that is macroscopic and uses geometrical optics, over the miniaturized unit that is based on micro-optics and needs physical optics design, down to the active nano-photonics entity that allows steering light truly at the nano-scale but which requires to be designed with rigorous methods that provide full wave solutions to the governing Maxwell’s equations. A design for manufacture of next generation optical applications necessarily requires to bridge the gap between the different length scales and to consider the design at a holistic level. At the core are optical simulation models developed and used in the academic research and the one used for optical designs in industry. Up to now, only the academic partners apply an integral approach to include micro- and nano-photonics in their simulations. Together with the industrial partners projects will be launched to promote the academic developments in optical design and simulation over different length scales towards the industry. The industry will use the know-how to consolidate their expertise, expand their businesses, and occupy new fields of activities. For each research subject, may it be nano-photonics, micro-optics or system engineering, a channel can be provided to access particular knowledge and/or stimulate collaborations.

Keywords: nano photonics,micro optics,optical systems
Dissecting the (epi)genetic origins of phenotypic variation and metabolic disease susceptibility (DismantlingNoise)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 1997853.0
EU funding (EUR): 1997853.0
Participants: 1
Project status: CLOSED

Current estimates place the prevalence of obesity beyond 1 billion by the year 2030. As a critical risk factor for heart disease, diabetes and stroke, obesity represents one of the chief socio-economic challenges of our day. While studies have mapped a genetic framework for understanding obesity, the etiological contribution of several regulatory layers, and in particular epigenetic regulation, remain poorly understood. A perfect example, we know that isogenic C57Bl6/J mice can vary by as much as 100% in body weight upon high fat feeding; currently, we have no mechanistic explanation for the emergence of such phenotypic variation. Here, I propose three aims dedicated towards understanding the (epi)genetic control of phenotypic variation and disease susceptibility. First, we will catalogue epigenome and phenome variation to an unprecedented depth and resolution in the isogenic context. Next, we will examine two completely novel models of epigenetically sensitized bi-stable obesity and thus begin a mechanistic dissection of phenotypic variation. Finally, we will map a series of gene-gene and gene-environment epistasis interactions including eight models of developmental plasticity and approximately a dozen chromatin regulator mutants. The latter epistasis matrix will identify the molecular mechanisms that trigger, amplify and buffer phenotypic variation and stochastic obesity in mice. The functional (epi)phenomics approach is unique. It builds the first unbiased framework against which to understand developmental plasticity and phenotypic variation, and at the same time generates powerful resources for disease researchers worldwide.

Keywords: stochastic disease,stochastic obesity,phenotypic variation,chromatin,suvar,h3k9me3,epigenomics,phenome
Commercialization of TREG cells sorting and proliferation in vitro for the production of vaccines for the treatment of type 1 diabetes. (TREGS4DM1)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Poland
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The applicant aims at delivering economically sustainable and innovative cell therapy dedicated to the treatment of DM1 with the use of TREGs vaccine. The TREG therapy, covers almost all aspects listed in the call, i.e. cell identification, sorting, culture, multiplication (all 4 steps covered in patent), banking, transport, delivery (running clinical trial) and strict quality control. The project’s objective is to increase the commercial success of the therapy while making it economically effective to the payer (state, local government, national health funds/insurance). The project’s outcome will be an innovative model for treatment of highly devastating disease even with the possibility of preventing highly undesirable side effects for a patient and on a macro-scale for the economy, society and pension scheme. However, in scaling-up, the Company has to identify regulatory pathways to abide even when the technology is out of scope of current regulatory landscape. New therapy means also identification of new business models. Reaching market authorization will be determined on the basis of acceptance of currently carried out academic clinical trials and any further clinical trials ordered by the EMA. Elaboration of feasibility study will allow PolTREG to prepare the necessary strategy for this regulatory requirements.

Keywords: treg cells,autologous vaccine,type 1 diabetes
Predictive Neural Information for Proactive Actions: From Monkey Brain to Smart House Control (Plan4Act)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Denmark
Call: FET Proactive: emerging themes and communities (FETPROACT-2016, 2016)
Start date: 2017-01-01
End date: 2021-04-30
Duration (months): 52.0
Total project cost (EUR): 4236000.0
EU funding (EUR): 4236000.0
Participants: 5
Project status: CLOSED

Planning and mental simulation of actions and outcomes are a major cognitive trait of humans. We predict action consequences and perform goal-directed actions in proactive, forward-looking ways. By contrast, systems that lack predictive planning are reactive and dominated by reflex-like, cumbersome behaviors. Most currently existing brain-machine-interfaces (BMI) fall into this category. Plan4Act sets out to go beyond this by inferring actions from action-predicting neural activity of complex action sequences. Neurophysiology in non-human primates recently revealed that such encoding is far more widespread than previously thought. The goal of the Plan4Act project is to record and understand predictive neural activity and use it to proactively control devices in a smart house. The far-future vision behind this is to endow motor-impaired patients with the ability to plan a daily-life goal – like making coffee – and achieve it without having to invoke one by one every single individual action to reach this goal. To approach this complex problem, we record multi-unit action predicting activity in macaques (WP1), model this by adaptive neural networks (WP2), design therefrom an embedded (FPGA-based) controller (WP3), and interface it with a smart house (WP4) to control action sequences with a clear look-ahead property. The main outcome of this project is a system that integrates the above components at TRL4 for which we quantify improved reaction speed and robustness of this type of proactive BMI control. The understanding and use of predictive neural signals for machine control is novel and methods, algorithms, and hardware developed to translate predictive planning from neural activity to technology create the major general impact of this project. Potential translational and commercial interests will be assessed by our industrial partner, where specifically the embedded controller and its smart house interface are expected to create near-future commercial impact, too.

Keywords: brain machine interfacing
Smart high-frequency environmental sensor networks for quantifying nonlinear hydrological process dynamics across spatial scales (HiFreq)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Australia,Germany,Germany,Spain,Spain,Sweden,Sweden,New Zealand,France,France,United States,Canada,Japan,United Kingdom,Luxembourg,United Kingdom,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2016-12-01
End date: 2022-02-28
Duration (months): 63.0
Total project cost (EUR): 2335500.0
EU funding (EUR): 2115000.0
Participants: 24
Project status: CLOSED

Regulators and industries are challenged by the difficulty to analyse and predict the impact of nonlinear environmental processes on short-term and long-term responses of ecosystems to environmental change. Until very recently, the development of most conventional monitoring, forecasting and prediction tools has been based on the assumption of stationary environmental systems. In the context of global change these tools are increasingly pushed towards and even beyond their design limits (the latter resulting in the first line from the prevailing limitations in spatial and temporal resolution of environmental observations). For this project, we propose a rationale stating that only novel, high-frequency/high-resolution environmental monitoring and predictive modelling will yield new process understanding of ecosystem functioning. Technological progress offers as many opportunities as it triggers challenges: what is needed now are new strategies to generate, manage and analyse BIG DATA at unprecedented spatial and temporal resolution. Innovation can only stand as a synonym for ‘significant positive changes’ if [a] we manage to clearly state the challenges (global change & non-stationarity) and problems (generating and managing high-frequency information) and [b] transform them into solutions, i.e. the quantification and prediction of environmental responses to global change as a prerequisite for designing and implementing adaptation and/or mitigation strategies wherever needed. The timely outcomes of this research project will hence be of great relevance for the scientific community, regulatory agencies, and the private sector.

Keywords: distributed sensor networks,high frequency environmental sensing
ULtra ThIn MAgneto Thermal sEnsor-Ing (ULTIMATE-I)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Spain,Argentina,Spain,Serbia,France,France,United States,Chile,Peru,Brazil
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 1692800.0
EU funding (EUR): 1656000.0
Participants: 12
Project status: SIGNED

Magnetic field sensing is a wide and important area of research and technological development in which every new magnetic or spintronic phenomenon discovered there would be an attempt to exploit it for magnetic sensing applications with improved cost-performances. Magnetoresistance is the ratio of the electrical resistance of a material with and without an applied magnetic field. This effect together with anisotropic magnetoresistance has led to a wide range of compact and high-sensitivity magnetic sensors for diverse areas of applications: Geophysics, Astronomics, Archeology, Health Care, and Data Storage. The basic physics of these effects are included in emergent field of Spintronic, field of knowledge that deals with the generation, propagation, processing and detection of spin currents. New effects appear with the spin currents as a central property like Spin Hall magnetoresistance (SMR) in hybrid materials ferromagnet/nonmagnetic metal; and other related phenomena: the Spin Hall Effect (SHE) and the Spin Seebeck Effect (SSE) where thermal sensing emerges. If we combine spintronic materials with multiferroic one’s new functionalities can be exploited where electric-field controls spin currents. These effects can be implemented in new strategies to design nanoscale devices. The development of both types of sensorsn thermal and magnetic sensors shares basic principles of spintronic, then we propose to work in ULTIMATE-I project with new hybrid combination of materials in which to better perform the spin to charge conversion, control of spin currents and producing sensor prototypes with outstanding performance. ULTIMATE-I project involves twelve partners with a strong background on spintronic, magnetic and multiferroic materials from EU and Third Countries, which will dedicate to solve common problems in nanomagnetism, generation and manipulation of spin currents, that affect the detection and sensitivity of sensors.

Keywords: magneto thermal transport,spin hall effect,spin seebeck effect,spin orbit coupling,structure related properties,nanotechnology device applications in sensing system
Untangling the pathophysiology of congenital disorders of glycosylation affecting the OST complex (OST-CDG-omics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Congenital disorders of glycosylation (CDG) are a group of over 100 inherited disorders characterised by defective glycosylation of proteins and lipids. Although the phenotypic and genetic characteristics of CDG as a whole are well established, their pathophysiology is poorly understood. In addition, the phenotype of affected patients is extremely variable, with dramatically different clinical presentations often appearing in patients with mutations in the same gene. I plan to investigate the link between pathogenic mutation and phenotype using recent advances in omics technologies, with a focus on the regulation of genes implicated in the pathophysiology of CDG. Firstly, using transcriptomics and epigenomics, I will identify the mechanism by which mutations in homologous genes encoding subunits of the oligosaccharyltransferase (OST) complex cause divergent phenotypes, thought to be due to differences in the regulation of tissue-specific transcription. The primary model for these studies will be the MAGT1 gene, mutations in which can lead to either a severe developmental disorder (MAGT1-CDG) or an isolated primary immune deficiency (XMEN). Secondly, using glycoproteomic techniques, I will study the proteins most affected by aberrant glycosylation in CDG affecting the OST, thereby characterising their pathophysiology in both patient-derived and modified cell lines. findings will be further investigated using targeted techniques such as LC-MS/MS. In summary, this study will simultaneously provide valuable insight into both the pathophysiology of CDG and the functional regulation of the OST complex, an understudied aspect of cell biology.
Establishing the new EEN Services for the Enhancing the Innovation Management Capacity of SME's in Mecklenburg-Vorpommern (INSERV M-V)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Germany
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 21875.0
EU funding (EUR): 17500.0
Participants: 3
Project status: CLOSED

The project relates to the design and implementation of assessments and consulting as a part of a new introduced service of the Enterprise Europe Network. The new service addresses small and midsized Enterprises (SME) with outstanding potential of innovation and internationalization. The new service comes as a Seven-Day Assessment and Consulting Process in two varieties. Both processes have the aim to enhance the innovation and internationalization capacities of the management and of the SME as a whole. First called KAMP. This is the ‘Key Account Management Process’ which is provided to beneficiaries who will introduced by the EEN by a special proposal and selection process in advance of the KAMP. Second called IMEP, ‘Innovation Management Enhancement Process’, is a different process which includes additionally the evaluation and selection process as part of the assessment and consulting process. Tools deployed for these two processes will be proprietary, designed and implemented by Steinbeis Europa Zentrum (SEE) and price awarded which includes a manifold of modules to assist the process. The project will be driven forward by three partners (participants) whereby each them is a specialist in implementing such assessments and consulting although in a different manner. This project gives the opportunity to the partners to harmonize their styles of work and even to enhance their capacities by this common.

Keywords: assessment,consulting,management,innovation,technology