Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fluxes, Interactions and Environment at the Land-Ocean Boundary. Downscaling, Assimilation and Coupling (FIELD_AC)

Framework: FP7 — Cooperation
Programme: Space
Destination: Space-based applications at the service of the European Society
Action type: Collaborative project
Countries involved: Spain,Belgium,France,Germany,Poland,United Kingdom,Italy,Denmark
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 4229558.0
EU funding (EUR): 3309416.5
Participants: 9
Project status: CLOSED

Coastal-zone oceanographic predictions seldom appraise the land discharge as a boundary condition. River fluxes are sometimes considered, but neglecting their 3D character, while the “distributed” continental run-off is not taken into consideration. Moreover, many coastal scale processes, particularly those relevant in geographically restricted domains (coasts with harbours or river mouth areas), are not well parameterized in present simulations. Because of this situation, local predictions still present significant errors and are not robust enough, even being locally wrong for sharp gradient events, such as flash flood discharges into the Mediterranean sea. This hampers decision-making in coastal zones. The FIELD_AC project aims at providing an improved operational service for coastal areas and to generate added value for shelf and regional scale predictions from GMES Marine Core Services. Local assimilation will be analysed together with advanced error metrics to provide a reliable service that can be transferred to public and private parties, using the spin-off company that will result from the project. This will be achieved by the introduction of more comprehensive “land” boundary conditions, improved local parameterizations and new coupling terms/strategies for the studied field cases. They cover a representative range of meteo-oceanographic drivers for four “geometrically” restricted domains (Catalan coast, Venice Gulf, Liverpool Bay and the Wadden Sea). FIELD_AC will bridge the gap from shelf predictions to local (river mouth or harbour/beach scales) simulations required at the coastal zone. This will result in a wider demand for operational services and an enhanced use of in-situ and remote observations. Such improvements (services and expertise) will require the advancement of the present state of the art.

Keywords: gmes added value,downstreaming,downscaled coupling,coastal domains
Bridging Between Organocatalysis and Biocatalysis: The Powerful Enamine Mechanism of Organocatalysts Engineered into the Tautomerase Superfamily Scaffold (PROZYMES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Netherlands
Call:  (ERC-2009-StG, 2009)
Start date: 2010-05-01
End date: 2015-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Proline and related secondary amines were found to be efficient organocatalysts of aldol, alkylation, Michael addition, and other challenging bond-forming reactions. The design of even more efficient systems that would allow extending this remarkable catalytic strategy to a useful and environmentally benign synthetic methodology would be highly desirable. This proposal aims to develop a new class of biocatalysts that use the powerful proline-based enamine mechanism of organocatalysts but that take advantage of the water solubility and stereochemical control available with enzymes. As a scaffold for engineering, we will exploit the active-site template of the tautomerase superfamily proteins, the only known group of enzymes that has the unique feature of using a N-terminal proline in catalysis. By systematically screening tautomerases for promiscuous carbonyl transformation activities, we aim to demonstrate that Pro-1 residues within these tautomerases can react with carbonyl compounds to give enamine intermediates, and thus may facilitate various bond-forming reactions. The most promising enzymes will be used in directed evolution experiments to enhance the desired activities to a practical level. For this, new screening and selection methods will be developed that allow the efficient passage through protein sequence space. Furthermore, unnatural secondary amines will be introduced by total chemical synthesis. In this way, we envision to generate superior biocatalysts for carbon-carbon bond-forming reactions. The idea of using a protein scaffold in which a catalytic proline is present as nucleophile and that has a unique reactivity to form enamines would be a completely new approach to making carbon-carbon bonds. It does not copy something in Nature, but is based on the synthetic requirements of the desired bond-forming reactions. I believe that this type of approach is the future of enzyme engineering and is the key to more application of biocatalysis in industry.

Keywords: catalytic promiscuity,enamine catalysis,biocatalysis,enzyme engineering
Ionisation-based detector of airborne bio-agents, viruses and toxins for fast-alert and identification (BIO-PROTECT)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of citizens
Action type: Collaborative project
Countries involved: France,United Kingdom,Finland,Germany,Denmark,Lithuania
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-06-01
End date: 2014-01-31
Duration (months): 44.0
Total project cost (EUR): 3955203.57
EU funding (EUR): 3125577.0
Participants: 9
Project status: CLOSED

The malevolent use of Anthrax spores on civilians in late 2001 has shown the necessity to protect European citizens from criminal use of biological agents and viruses. Although these attacks had been punctual and crude, more sophisticated attacks on dozens or hundreds of injured or killed people are conceivable. When launching such an attack its success depends on concentrating a sufficient amount of pathogens in a defined area. Hence safeguarding a certain area regarding biological agents demands the detection of pathogenous bacteria, spores and viruses in various matrices (e.g. Anthrax in flour or sugar) or suspicious aerosols. This can only be accomplished by triggering a short-term alarm and its validation as well as the identification of the type of threat. Since most of the bio sensors available are laboratory bound or require special equipment which needs training as well as experience, new systems are needed. The concept of BIO-PROTECT is the development of a fast-alert, easy-to-use device to be applied for detection and identification of airborne bacteria, spores, viruses and toxins . Its technology is based on bioaerosol detection by fluorescence, scattering and background aerosol measurement followed by ionisation of air flow and analysis of the spectrum of relative speed of passage, which, in turns, enables identification of harmful biological agents. This device may also be used for controlling potential accidental release of bio-agents from biotechnology laboratories.

Keywords: ionisation detector airborne bio-agents,viruses and toxins fast-alert gas chromatography ion mobility spectrometry gc-ims
30-year re-analysis of CARBON fluxES and pools over Europe and the Globe (CARBONES)

Framework: FP7 — Cooperation
Programme: Space
Destination: Space-based applications at the service of the European Society
Action type: Collaborative project
Countries involved: France,France,United Kingdom,Germany,United Kingdom,Switzerland,Netherlands,Germany,China,United Kingdom,United Kingdom,Finland,France
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-04-01
End date: 2013-03-31
Duration (months): 36.0
Total project cost (EUR): 3491018.07
EU funding (EUR): 2561699.0
Participants: 15
Project status: CLOSED

The carbon Environmental Service (CARBONES) will provide the first multi-decadal reanalysis of the global carbon cycle and a service to provide a rolling update of this analysis. This will include the &quot;essential climate variables&quot; (defined by the Global Climate Observing System) of atmospheric carbon dioxide, leaf area and biomass in various categories. No integrated reanalysis includes these climate variables. This reanalysis will combine the primary long-term observations of the terrestrial and oceanic carbon-cycles (atmospheric concentrations, remotely-sensed surface properties and in-situ ecological measurements) using data assimilation techniques. The service will provide a well-founded baseline for predicting future responses of the carbon-cycle to climate change, and for services such as the Atmospheric and Land Service. It will also act as a benchmark for these core services during the period of overlap. The primary users for the reanalysis are climate modellers who need an initial condition for their predictions and, for the same reason, groups calculating changes in carbon stocks. Thus a benefit will be an independent check, globally, on reporting of carbon inventories for the United Nations Framework on Climate Change. Access to the results will be provided by a flexible and user-friendly web-interface The techniques used for the reanalysis will also be used, in conjunction with the core services, to provide a rolling update on the state of the carbon cycle. This will evolve towards an operational, integrated, carbon-cycle monitoring capacity as a potential downstream service.

Keywords: carbon cycle,reanalysis,climate variables,fluxes,assimilation,remote-sensing,global change
BiO-dOSimetric Tools for triagE to Responders (BOOSTER)

Framework: FP7 — Cooperation
Programme: Security
Destination: Restoring security and safety in case of crisis
Action type: Collaborative project
Countries involved: France,Ireland,Germany,Hungary,France,Spain
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-07-01
End date: 2013-06-30
Duration (months): 36.0
Total project cost (EUR): 4583559.24
EU funding (EUR): 3284291.0
Participants: 7
Project status: CLOSED

The effective management of an incident involving exposure of large numbers of people to radioactive material, whether accidental or following malevolent use of radioactivity, requires a mechanism for rapid triage of exposed persons. The BOOSTER project addresses this requirement under Security Topic SEC-2009-4.3.2 – Bio-dosimetric tools to manage radiological casualties. Current biodosimetric approaches frequently involve cytogenetics. The analysis of dicentric/ ring chromosomes is the mechanism of choice for precise estimation of an individual’s exposure. Current optimisation of such analyses involves the automation of various steps in the process. However, chromosome analyses are performed on the first mitosis post-exposure and thus a significant limiting factor remains a cell culture step (2 days) that is impossible to reduce. New biodosimeters are required that may not bring the same precision as cytogenetic analysis but will permit triage in the first hours post-accident into three populations (i.e. to identify individuals that require no further intervention, those who require close follow-up and those who require hospitalisation). BOOSTER is a capability project designed to research and develop new bio-dosimetric tools in order to quickly evaluate the level of potential casualties, determine by appropriate sensors their consequences, allow an efficient triage of exposed people, integrate a useful and usable toolbox, train civil protection operators and define commercial exploitation potentialities. The BOOSTER project will use an integrated approach to deliver new bio-dosimetric tools. We propose to optimise existing tools for assessment of a radiological situation and to develop novel biodosimetric procedures for estimation of radiation exposure in cells from patients. These approaches will be combined in a prognostic toolkit that will allow effective management of exposed persons presenting at triage.

Keywords: bio-dosimetric tools,sensors,responders,crisis management,civil protection
GMES for Africa: Regional Network for Information Exchange and Training in Emergencies (GARNET-E)

Framework: FP7 — Cooperation
Programme: Space
Destination: Cross-cutting activities
Action type: Coordination and support actions
Countries involved: United Kingdom,Morocco,South Africa,Portugal,Netherlands,Sweden,Austria,Kenya,Belgium,Belgium,United Kingdom,Ethiopia,Belgium,Nigeria,Cabo Verde
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 1336301.0
EU funding (EUR): 999470.0
Participants: 20
Project status: CLOSED

To enable and enhance the ability of African states to use satellite Earth Observation for the management of natural and man-made humanitarian emergencies. To develop a network of EU, African organisations and African users, in order to build economic, technical and commercial capacity within African states, along the priority lines being identified in consultation with the African Union under the ‘GMES and Africa’ initiative.

Keywords: gmes,africa,emergency response,network,wealth creation,capacity building
OPARUS (Open Architecture for UAV-based Surveillance System) (topic : SEC-2009.3.4.1 Continuity, coverage, performances, secure datalink) (OPARUS)

Framework: FP7 — Cooperation
Programme: Security
Destination: Intelligent surveillance and enhancing border security
Action type: Coordination and support actions
Countries involved: France,Poland,United Kingdom,France,Germany,Spain,Israel,Italy,France
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-09-01
End date: 2012-05-31
Duration (months): 21.0
Total project cost (EUR): 1405309.68
EU funding (EUR): 1188312.75
Participants: 14
Project status: CLOSED

The goal of this project is to elaborate an open architecture for the operation of unmanned air-to-ground wide area land and sea border surveillance platforms in Europe. This architecture is based on analysis of concepts and scenarios for UAV-based aerial surveillance of European borders. It takes into account the emerging legislation for insertion of UAS into controlled civil airspace. The technical aspects cover surveillance sensors, appropriate aerial platforms, secure datalinks, communication networks and generic ground control station. The project particularly focuses on cost-efficient solutions enabling maximum efficiency of the UAS operations for European border surveillance.

Keywords: open architecture - uav - border surveillance -
COnverters broadband low power high perforMancE for Telecommunications in Space (COMETS)

Framework: FP7 — Cooperation
Programme: Space
Destination: Strengthening the foundations of Space science and technology
Action type: Collaborative project
Countries involved: France,Germany,France,United Kingdom,France
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-05-01
End date: 2013-09-30
Duration (months): 41.0
Total project cost (EUR): 3533118.4
EU funding (EUR): 1994943.7
Participants: 6
Project status: CLOSED

For the satellite digital communication systems designed in a tough competitive context, the European Space Industry requires advanced components in terms of performance, flexibility and power consumption. Indeed, future telecommunications payloads will contain digital processors to make best use of scarce spectrum and to offer best operational flexibility to operators and end-customers. This puts ever more drastic requirements for Data Converters and in particular onto Analogue to Digital Converters (ADC). As they are strategic components for satellite communications, the COMETS project research effort on European sourced radiation hardened ADC's is mandatory 1) to respond to the demand for such high conversion capacity, currently not available on the market and 2) to ensure long-term European independence. The consortium’s efforts will be driven by e2v. Starting from system level requirements is fundamental to develop the right ADC expected by the industry and to open wide market perspectives to it. The project "STEP1" will lead to the 10bit 1.5GSps rad-hardened and low power ADC updating the State of Art, to serve mid-term critical needs of the Space industry. The ESCC evaluation will conclude the STEP1. As longer term needs see increasing performances, a 12bit ADC beyond State-of-the-Art is then focused in the frame of the "STEP2" taking advantage of the advanced technology developed by Infineon. The total project is planned on 3 years. Specifications derived from advanced system level needs, proven design and radiation hardening expertise, high performance technology and related device modelling are major assets for the COMETS project and form the panel of factors for the winning solution. Moreover, the European space industry will keep control on the design and production chain of the ADC’s for Space telecommunications. This will ensure the Europe’s supplying independence for those strategic components.

Keywords: adc high-speed esscc
Biogenesis and Functions of Telomeric Repeat-containing RNA (BFTERRA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Switzerland
Call:  (ERC-2009-StG, 2009)
Start date: 2009-10-01
End date: 2014-09-30
Duration (months): 60.0
Total project cost (EUR): 1602600.0
EU funding (EUR): 1602600.0
Participants: 1
Project status: CLOSED

Telomeres are heterochromatic nucleoprotein complexes located at the end of linear eukaryotic chromosomes. Contrarily to a longstanding dogma, we have recently demonstrated that mammalian telomeres are transcribed into TElomeric Repeat containing RNA (TERRA) molecules. TERRA transcripts contain telomeric RNA repeats and are produced at least in part by DNA-dependent RNA polymerase II-mediated transcription of telomeric DNA. TERRA molecules form discrete nuclear foci that co-localize with telomeric heterochromatin in both interphase and transcriptionally inactive metaphase cells. This indicates that TERRA is an integral component of telomeres and suggests that TERRA might participate in maintaining proper telomere heterochromatin. We will use a variety of biochemistry, cell biology, molecular biology and microscopy based approaches applied to cultured mammalian cells and to the yeast Schizosaccharomyces pombe, to achieve four distinct major goals: i) We will over-express or deplete TERRA in mammalian cells in order to characterize the molecular details of putative TERRA-associated functions in maintaining normal telomere structure and function; ii) We will locate TERRA promoter regions on different human chromosome ends; iii) We will generate mammalian cellular systems in which to study artificially seeded telomeres that can be transcribed in an inducible fashion; iv) We will identify physiological regulators of TERRA by analyzing it in mammalian cultured cells where the functions of candidate factors are compromised. In parallel, taking advantage of the recent discovery of TERRA also in fission yeast, we will systematically analyze TERRA levels in fission yeast mutants derived from a complete gene knockout collection. The study of TERRA regulation and function at chromosome ends will strongly contribute to our understanding of how telomeres are maintained and will help to clarify the general functions of mammalian non-coding RNAs.

Keywords: telomeres,heterochromatin,transcription,genome stability,rna promoter
Regulatory mechanisms coordinating replication integrity and intra-S repair (REPSUBREP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Italy
Call:  (ERC-2009-StG, 2009)
Start date: 2009-10-01
End date: 2014-09-30
Duration (months): 60.0
Total project cost (EUR): 1841600.0
EU funding (EUR): 1841600.0
Participants: 1
Project status: CLOSED

The RecQ family of helicases, including BLM in human and its Saccharomyces cerevisiae homolog Sgs1, have important roles in maintaining genome stability. Sgs1 plays a specific role in response to intra-S DNA damage by resolving the pseudo double HJs resulting from replication-related sister chromatid junctions (SCJs). These catenated DNA structures are thought to represent template switch (TS) intermediates. Although the molecular mechanism is largely unknown, TS is thought to represent a major mechanism to bypass damage during replication. We recently showed that two genetic TS pathways, both of which involve homologous recombination (HR) factors, can lead to bypass of damage by means of SCJs and that their choice is regulated by sumoylation of a key replication factor, PCNA. We also found that the main TS pathway operating in cells involves the coordinated action of HR with the post-replication repair proteins Rad18, Rad5 and Mms2-Ubc13, which exert their role in promoting SCJ formation by means of ubiquitilating PCNA. Previously we showed that the resolution activity of Sgs1 and Top3 is regulated by Ubc9- and Mms21-dependent sumoylation, but the SUMO targets implicated with Sgs1 in this process remained unknown. In this project we plan to characterize the pathways that lead to TS and to understand the factors that promote different steps of this process and their regulation, using in vivo and in vitro approaches. We will attempt to understand how sumoylation is activated by intra-S damage and to address how the formation and subsequent resolution of these X-structures is coordinated with chromatin remodeling functions and topological transitions. We will characterize the X-shaped molecules formed during replication and we will attempt their visualization.

Keywords: intra-s repair template switch sumo and ubiquitin modifications replication checkpoint pseudo double holliday junctions