Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards the Licensure of The First Protein-Based Universal Pneumococcal Vaccine (RVX-001)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2384988.0
EU funding (EUR): 2384988.0
Participants: 1
Project status: SIGNED

ReNewVax Ltd. is a vaccine platform company whose mission is to develop efficient yet affordable vaccines to the world’s most acute bacterial disease challenges. The company has developed, patented (WO2022/148954), and successfully completed the preclinical trials for a new breakthrough vaccine, RVX-001, targeted at a bacterium called Streptococcus pneumoniae (or the pneumococcus), one of the major causes of pneumonia, meningitis and sepsis, around the globe. Our innovation relies on a proprietary technology platform built on the combined use of genomics, bioinformatics and ex vivo human predictive models. RVX-001 was designed to protect against all 100+ known pathogenic variants of this life-threatening bacterium, making RVX-001 the world’s first vaccine to provide universal coverage against the pneumococcus, including multi-antibiotic resistant strains. The aim of this project is to conduct a combined Phase I/IIa clinical study to evaluate the safety, reactogenicity and immunogenicity of RVX-001. We seek funding from the EIC accelerator programme to unlock access to larger equity investment in view of either partnering with, or out-licensing the asset to a larger organisation and progressing it further to late-stage clinical trial and its commercialisation thereafter.

Keywords: rational vaccine design platform,streptococcus pneumoniae,anti microbial resistance
Gender discourses in Archaeology. Conceptual models, stereotypes and asymmetries in the Spanish Iron Age (1st millennium BCE) (STENA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 3
Project status: CLOSED

This project focuses on the gender roles in the Iron Age societies of Spain, a tradition that epitomises the challenges in gender equality on a global basis. The Iron Age has been a crucial period that has influenced the construction of national identities across Europe, prioritising activities assumed carried out by men (war, metalwork, cattle raising), relegating women and alternative gender identities to a secondary stance. This emphasis on male-dominated interpretations have taken women’s agency away and led us to understand that history happens to women while men make it happen. This project addresses, therefore, an urgent key issue of the contemporary world: gender equality. This research will incorporate traditional archaeological analysis of sources and material culture with cutting-edge Digital Humanities techniques combining Corpus Linguistics and Geographical Information Sciences. The first part of the research will assess the criteria behind the interpretations of gender, examine how archaeologists have reached these conclusions and evaluate the strength of their argumentation. A second stage will produce gender-disaggregated data and a novel narrative for the Iron Age that will potentially transform how the discipline understands the role of gender in the past. In this way, this project will produce a transferable methodology capable of unveiling and visualising the conceptual models that underpin the main argumentative pillars to construct gender-related discourses, interpretations and stereotypes. At the same time, this research will bring hidden and overlooked data about gender to the forefront, break current harmful gender stereotypes and bridge the gender data gap. Finally, to ensure that the paradigm shift goes beyond academia, this research has an ambitious dissemination programme for non-academic audiences. Therefore, this field-defining project will make a broad impact on Archaeology and beyond.

Keywords: iron age archaeology,protohistory,gender,gender stereotypes,spain,corpus linguistics,discourse analysis,argumentation analysis,conceptual models,geographical text analysis
Understanding emergent physical properties of chromatin using synthetic nuclei (SynthNuc)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1999550.0
EU funding (EUR): 1999550.0
Participants: 2
Project status: SIGNED

The main aim of this proposal is to resolve how the physics of molecular-scale activities result in the emergent material properties of chromatin and how those contribute to chromatin organization and function. Mounting evidence suggests that the material properties of chromatin regulate essential nuclear processes. Chromatin has been studied with two disconnected approaches; pure in vitro studies, perfectly suited for careful biophysical measurements on single DNA molecules but lacking the complexity of a cell, or intact cell measurements, with limited access to measure material properties and small-scale chromatin dynamics. The physical properties of chromatin, however, are emergent and result from the molecular activities that are in turn regulated by those properties. As a consequence, it is crucial to establish new experimental assays that connect these two scales and levels of complexity. Here, I will bridge the gap in scales and biochemistry between pure in vitro assays and measurements in intact cells by reconstituting chromatin processes in Xenopus laevis egg extracts across scales. I will combine quantitative microscopy, optical tweezer measurements, and theory to biophysically characterize the self-organization of protein-DNA co-condensation and loop extrusion and single chromatin molecules of increasing complexity. To bridge the microscopic and the macroscopic scales, I will assemble synthetic nuclei made of pre-engineered DNA sequences, which allows for exquisite control of DNA length, amount, and chromatin activities. In combination with microrheology, micropipette aspiration, and magnetic tweezers, I will unravel how the collective behavior of chromatin activities gives rise to the emergence of large-scale material properties of chromatin. This project will provide a physical description of the material state of chromatin across scales and contribute to reveal the basic physical principles that govern nuclear organization and function.
Stretchable micro-Organic Electrochemical Transistors Circuits for Neural Interfacing (uOECT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

This project is aimed at developing active soft neural probes for high-resolution, high-density interfacing of the peripheral nervous system (PNS). The availability of high-resolution PNS interfaces is key to the treatment and management of a number of common medical conditions such as neuropathic and chronic pain, paralysis, major depression, and epilepsy. Two major challenges that hinder progress in this area are: i) Mechanical mismatch between the neural tissue and the conventionally used neural probe materials (e.g. metal wires). ii) The electrode density and spreading is limited by the use of passive linear probes. This project seeks to address both these issues by developing miniaturized inert, ultra-soft (E<50kPa) multi-headed probes, which can be actuated in situ to record from a large volume of the neural tissue with high spatial resolution. This is combined with integration of multiple active neural transducer elements and integrated amplification circuitry for high signal fidelity and integrated multiplexing circuitry for addressing, into each probe arm. This approach simultaneously increases spatial resolution and signal fidelity of neural interfacing, while enabling chronic implantability due to decreased chronic immune response and scarring through the inert and mechanically compliant nature of the probes, as well as minimized tissue damage during implantation.

Keywords: organic electrochemical transistors,oects,soft neural probes,neural interfaces,soft electronics,stretchable electronics
De-Coding Adhesion, Degradation and Immunomodulation Properties of Self-Assembling Peptide Hydrogels for Programmed Tendon Regeneration (DeCodeGels)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-06-01
End date: 2031-05-31
Duration (months): 60.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 1499999.0
Participants: 1
Project status: SIGNED

Despite recent advances there is still a clear need for injectable and regenerative biomaterials that can spatiotemporally modulate the inflammation and, in parallel, induce the desired regenerative pathways. Usually, biopolymeric hydrogels need a narrow and somewhat opposite set of physical and biological properties which allow for their degradation, adhesion as well as immune cell invasion to allow complete tissue regeneration. To resolve this issue, following my unique interdisciplinary expertise, I plan to develop new injectable self-assembling peptides (SAPs) biomaterials that simultaneously: i) possess improved adhesion to local tissues in vivo, ii) exhibit controlled degradation matching the desired regeneration outcome, and iii) allow tissue regeneration by enabling controlled immune cells invasion and progression of inflammation from neighbouring tissues. The basic rules for decoupling these properties will have broad implications to the biomedical community. Following injury, inflammation is the trigger of tissue repair, however, chronic inflammation is detrimental. The persistent inflammatory nature of tendinopathy contributes to localized tissue damage, often developing to a low-grade chronic inflammation with recurring tears. Unlike conventional anti-inflammatory therapies that merely address symptoms, DeCodeGels introduces an innovative therapeutic strategy utilizing temporally modulating SAPs biomaterials. This groundbreaking approach aims to i) initially induce a controlled, localized pro-inflammatory state, then ii) gradually transition this state to an anti-inflammatory environment over time to ultimately achieve a dual-purpose therapy that reverses chronic inflammation and promotes therapeutically driven healthy tissue regeneration. This single, multifaceted treatment has the potential to revolutionize our approach to chronic inflammatory conditions, offering a path to true healing rather than just symptomatic relief.

Keywords: self assembling peptides hydrogels immunomodulation biomaterial degradation biomaterial adhesion tendinopathy inflammation macrophages tendon regeneration
COST: Europe's most empowering research programme Strengthening science and innovation through research networking (SGA1-HE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: European Cooperation in Science and Technology
Destination: European Cooperation in Science and Technology
Action type: Coordination and support actions
Countries involved: Belgium
Call: Implementation of COST actions - Specific Grant under Framework Partnership Agreement (HORIZON-WIDERA-2021-COST-SGA, 2021)
Start date: 2021-11-01
End date: 2024-10-31
Duration (months): 36.0
Total project cost (EUR): 153000000.0
EU funding (EUR): 153000000.0
Participants: 1
Project status: CLOSED

Founded in 1971, COST is an intergovernmental framework for cooperation in science and technology (S&T). As defined in the COST Mission statement, COST provides networking opportunities for researchers and innovators in order to strengthen Europe’s capacity to address scientific, technological and societal challenges. To do so, COST funds bottomup, excellence-driven, open and inclusive networks for peaceful purposes in all areas of science and technology. According to COST Vision statement, COST is aiming at becoming the leading open networking tool in the ERA. In order to continue to pursue its Mission and Vision, the COST Strategic Plan defines three strategic priorities for the remaining part of Horizon 2020 and in Horizon Europe: - Promoting and Spreading Excellence - Fostering interdisciplinary research for breakthrough science - Empowering and retaining young researchers and innovators To implement those strategic priorities, COST focuses its efforts on strengthening its core business and implementing a range of complementary activities. The COST Association is the beneficiary of a Coordination and Support Action (CSA) following the Horizon Europe Work Programme 2021-22. The COST Association is an AISBL under the Belgian law with an integrated governance, management and implementation functions, creating the base for a responsible and accountable organisation where the COST Full Members have direct control. The legal and financial frame for the COST Association operations is provided via a Framework Partnership Agreement (FPA) and subsequent Specific Grant Agreements (SGAs). An overall budget of EUR 153 million was foreseen for the first SGA1 for a duration of 36 months, 1 November 2021 to 31 October 2024.

Keywords: networking,research and innovation,science and technology,knowledge sharing,interdisciplinary,openness,inclusiveness,bottom up,pan european cooperation,output oriented
Unraveling the cellular and molecular dynamics of adult neurogenic niches and brain-body communication during regeneration (RegenerationFly)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: CLOSED

The regenerative potential of the adult brain lies within the neural stem cells (NSCs), a group of dormant cells capable of generating specialized neurons and glial cells. NSCs are embedded in dedicated niches that are composed of heterogeneous cells, which provide a unique combination of signaling molecules and physical properties to support NSCs functions. However, how niche cells remodel to promote complex NSC activation for repair and act as cohesive unit still remains elusive. This project aims to delineate and genetically manipulate the niche cells in vivo and characterize their coordinated functioning in the transition of NSCs from quiescence to an active proliferative state during brain regeneration. We will take advantage of recently identified quiescent NSC-like cells in the adult brain of genetically versatile fruit flies, which activate upon injury for regeneration and integrate similar features to their mammalian counterpart. While the niche provides local cues to articulate the proliferation in the NSCs, peripherical tissues are also affected upon brain damage. Notably, metabolic relevant tissues as the adipose tissue and the gut are necessary to provide energy for the generation of new cells in the niches. However, which are the signaling molecules spanning upon damage and their source in the brain remains unknown. Thus, we propose to study the inter-organ crosstalk between the brain and other tissues during brain regeneration. Overall, this work will provide detailed knowledge about cell interactions within the niches and inter-organ communication upon NSC activation in response to tissue damage. By elucidating molecular and cellular mechanisms, this study aims to provide a comprehensive framework for harnessing the latent regenerative capacity of the brain, ultimately fostering advancements in regenerative medicine.

Keywords: neurogenesis,regeneration,inter organ crosstalk,drosophila
Chemo-enzymatic processing of bio-based building blocks to circular functional materials (CIRCULARIZE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Recent advances driven by the society’s need of implementing a more sustainable polymer chemistry, led to the development of several bio-based materials and the booming of the interest of using biocatalysts for polymer processing and recycling. The aim of CIRCULARIZE is to develop appropriate chemo-enzymatic methods to process bio-based resources to obtain advanced functional materials via the exploitation of highly selective reactions following the green chemistry principles. Further, the aim is, based on that knowledge, to improve the reaction efficiency of the biocatalysts and understand and control the surface and bulk properties of the produced materials in pursuit of novel smart materials and reactive surfaces. Current processes for the utilization of bio-based monomers and resources are unspecific and lead to products in poor quality due to side reactions. Specific biocatalysts could achieve optimal selectivity together with minimal damage to the monomers and polymers and provide high-quality advanced materials. When considering the multifunctional monomers deriving from biomass, the chemo catalytic techniques used by industry have some major shortcomings such as limited selectivity (leading to side reactions) and use of toxic catalysts and solvents. Using this knowledge, the CIRCULARIZE project will develop and apply techniques based on sustainable chemo-enzymatic processes, developing a series of fully bio-based hybrid polymers having smart characteristics (temperature-switchable, vitrimeric properties) while being able to finely tune their degradation via the insertion of enzyme-susceptible motifs. Methodologically, CIRCULARIZE strives to establish new approaches at the cross-sectorial biotechnology/polymer chemistry interface to extend the current knowledge on enzymes for polymer synthesis and processing and, in the long term, the development of a sustainable biopolymer chemistry able to build an endless selective carbon recovery loop.

Keywords: circular polymeric materials,functional polymers,surface functionalization,selective depolymerization,enzyme susceptible bonds
Data Stories: Producing stories about and with property and planning data (DATASTORIES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Ireland
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 2441425.0
EU funding (EUR): 2441425.0
Participants: 1
Project status: SIGNED

Planning and property data are the key evidence base for how cities are understood, planned and developed, informing public perception, guiding investments, and shaping policy. Yet, little critical attention has been paid to planning and property data and their lifecycles, circulation, politics, power and use in policy and stakeholder decision-making. This lacuna raises two important challenges that require redress if the validity of analysis, interpretation and decision-making is to be improved. First, transforming the ontological and epistemological understanding of planning and property data amongst those that utilise them. Second, fostering a reflexive approach to data politics and power in organisations that produce, share and use planning and property data. DATASTORIES will tackle these challenges by conducting research in a creative, highly engaged way with key stakeholders across three domains (state, business, NGOs/civil society). It will develop an innovative methodological approach that blends social science and research-creation methods, working with creative writers and artists, to map an entire data ecosystem (Dublin, Ireland), unpack data assemblages and produce a variety of data stories. 12 in-depth case studies will produce 36 data stories about and with planning and property data. The project will produce four key advances: new knowledge about the evidence-base for planning and property and its use; critical insight into the politics and praxes of data; novel research-creation methods and an assessment of their efficacy; and an extended conception of data stories and an understanding of their production and utility for different audiences. DATASTORIES will produce three ground-breaking impacts: conceptual – transforming the epistemology of planning and property research; applied – positively influencing the data processes and practices of key stakeholders; methodological – validating research-creation and data stories as social sciences methods.

Keywords: planning,housing,property,critical data studies,data ecosystem,data stories,research creation,evidence base