Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FunctIonal optoacousticS for imaging Early onsEt of Gut inflammation (IseeG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1453730.0
EU funding (EUR): 1453730.0
Participants: 1
Project status: SIGNED

The aim of this project is to functionalize contrast agents for multispectral optoacoustic tomography (MSOT) - a molecular "sensitive" ultrasound imaging technique - to develop a new targeted imaging approach for the early localisation of inflammatory processes. Inflammatory processes in the gastrointestinal tract often act like a Trojan horse - while camouflaging themselves with diffuse clinical symptoms, they may rapidly progress into life-threatening complications. To date, it has been difficult to precisely localize them in their early stages, and their detection remains the domain of invasive endoscopy. The invasive nature of this method not only restricts its use for early disease detection, but is a major limitation for repetitive or high-risk applications. MSOT uses laser light excitation and ultrasound detection to resolve different chromophores such as haemoglobin, lipids, and other metabolic parameters at depths of several centimetres. While we were using the response from endogenous chromophores for translational to a range of potential clinical applications, we discovered that dyes delivered via the oral route enable the dynamic visualization of the entire intestinal tract. This molecular-sensitive approach has the advantage that such contrast agents are not absorbed systemically and undergo excretion largely unchanged. Based on this, I hypothesize that it is possible to functionalize such contrast agents in order to put a molecular flag on inflamed areas in the gastrointestinal tract. After characterizing potential imaging targets in the intestinal lumen and developing imaging agents, we will take a translational research approach, moving from cells through small and large experimental animal models back to the human system. This research at the frontiers of medicine and physics may pave the way to non-invasive early detection and personalized treatment strategies while minimizing the procedural risk for affected patients.

Keywords: optoacoustics,molecular imaging
Many-body Theory of Local Chemistry in Cavities (MATHLOCCA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1999203.0
EU funding (EUR): 1999203.0
Participants: 1
Project status: SIGNED

Multiple experiments have demonstrated that chemical reactivity can be modified by collectively coupling molecules to electro-magnetic vacuum-modes of a cavity. This has led to a new interdisciplinary research field, often denoted as "polaritonic chemistry". Despite great effort, even key underlying theoretical mechanisms are not understood today. This has recently led to controversies about fundamental origins of the observations in the collective strong coupling regime. The main goal of MATHLOCCA is to develop a first verifiable quantum many-body theory for the problem. The theory will be truly many-body, discovering new physics in molecular models with a large number of coupled electronic, nuclear, and photonic degrees of freedom. Recent breakthrough findings of the applicant will lead to an unconventional ansatz: The theory explains polaritonic chemistry without polaritons. Instead it relies on the concept of collectively modified local dark states. This "dark state chemistry" will explain how collective strong coupling can modify chemistry on the single-molecule level, a long-standing open question. MATHLOCCA is multi-disciplinary, discovering fundamental new quantum many-body physics in new types of electro-vibro-photonic models. This will lead to applications also in cold atom platforms. A second main objective is to introduce a new numerical theory for general open quantum many-body simulations, in terms of an entanglement optimized density matrix unravelling. The key new paradigm is to dynamically optimize the unravelling of a density matrix into pure state trajectories, making the trajectories more amenable to classical representation. This new concept will radically shift capabilities for numerical simulations in polaritonic chemistry and beyond, while giving fundamental new insight on entanglement dynamics in open quantum many-body theory.

Keywords: polaritonic chemistry,quantum many body physics,non equilibrium dynamics,numerical methods
Targeting tertiary lymphoid structures using magneto-margination (MAGMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1970480.0
EU funding (EUR): 1970480.0
Participants: 1
Project status: SIGNED

Tertiary lymphoid structures (TLS) are ectopic lymphoid tissues that drive immune responses at sites of chronic inflammation. They are of widespread interest in biology and medicine since their presence dramatically influences disease course in autoimmune disorders, infection, and cancer. However, due to their small size and their development in chronically altered tissues, TLS cannot be selectively targeted or detected by imaging. The current project aims at developing new methods to map and eventually destroy the TLS in a non-invasive manner. To this aim, a new formulation of injectable superparamagnetic particles will be produced and targeted to the TLS. A set of innovations in contrast agent design and material chemistry will be developed to dramatically increase targeting efficiency compared to existing methods. By combining these innovations, intravenously injected superparamagnetic particles will accumulate in TLS in large numbers, thereby allowing their non-invasive detection by clinically available imaging modalities (magnetic resonance imaging) and emerging technologies (magnetic particle imaging). This will also open the possibility of thermal destruction of TLS using magnetic hyperthermia, providing a way to suppress a local immune response without affecting systemic immunity. The scientific advances and technologies of the MAGMA project will have clinically relevant applications, such as diagnosis of chronic inflammation, selection of patients for treatment with immune checkpoint inhibitors in cancer and spatially selective suppression of immunity in autoimmune diseases.

Keywords: tertiary lymphoid organs,magnetic resonance imaging,magnetic particle imaging
Postural influence on the evolution/co-evolution of the cranio-cervical complex in the Neandertal lineage (CR-EVOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

The modern human head and neck are very different from those of great apes, both from a morphological and postural point of view. However, differences in the cranio-cervical complex are also observed compared with our closest extinct ancestors, the Neandertals. But did morphological differences between modern humans and Neandertals have a biomechanical impact on their posture? Understanding the relationship between the head and neck from a broad evolutionary form and function perspective is crucial to ultimately resolving this question. CR-EVOL objective is to address the co-evolution of the cranium and cervical spine in the Neandertal lineage and determine to what extent biomechanical factors related to posture influenced this evolutionary process. The curvature and morphology of the neck have changed during human evolution. The sparse and incomplete fossil record suggests that differences in the cervical spine within the genus Homo are related to differences in the cranial shape. Moreover, it has been proposed that different hominin groups, including those from the NEA lineage, "solved" the requirements of erect posture in different ways. Thus, to directly test this question, the ER will receive training-through-research in key cutting-edge techniques and fundamental knowledge for his future as a researcher in palaeoanthropology: Phylogenetics (Beneficiary), Biomechanics (Secondment), and Hominin fossil record (Short visits). Also, the ER will be supervised and trained in broader aspects of academic activity, knowledge transfer, and career development, enabling him to position himself as a potential research leader.

Keywords: palaeoanthropology,human evolution,biomechanics,integration,3d imaging,european pleistocene hominins
Metaproteome-based leveraged microbiome management in the context of One Health (METAMIC 3)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,France,Netherlands,Belgium,Luxembourg,Spain,Switzerland,United Kingdom,Austria
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4404322.08
EU funding (EUR): 4404322.08
Participants: 31
Project status: SIGNED

One Health is an integrated, unifying approach that aims to sustainably balance and optimize the health of people, animals, and environment ecosystems. All three domains are interconnected by microbiomes. Microbiomes are present universally and are connected by species exchange, impacting human and animal health but also environmental and biotechnological processes. Targeted control of the taxonomic and functional microbiome composition by microbial effectors such as antibiotics, antimicrobial peptides, and phages could be a game changer for these fields. However, the impact of microbial key factors on modulating microbiomes, the mechanisms implicated and the functional consequences, are barely understood. A novel approach which provides unique insights into the dynamics and the roles of microbial effectors is metaproteomics. The metaproteomics approach allows us to quantify the microbial composition and the expressed metabolic functions as well as to detect phages, antimicrobial resistance associated proteins, and non-ribosomal peptides. Leading European scientists of the Metaproteomics Initiative (https://metaproteomics.org/) formed a strategic alliance to set up a powerful and interdisciplinary network called METAMIC to capitalize on the potential of metaproteomics for developing novel strategies for microbiome control, manipulation/engineering, and restoration based on microbial effectors. METAMIC will achieve this by training a new generation of highly skilled microbiome and metaproteomics scientists, spreading their knowledge in research, industry, the medical sector, and public authorities. Developing novel metaproteomics workflows and exemplifying them in various clinical and biotechnological field studies will provides important steps towards better understanding and managing our microbiomes in the future, fitting the key EU missions, including “climate change”, “climate-neutral and smart cities”, “soil deal”, “restore ocean and water”, and “cancer”.

Keywords: metaproteomics,microbiome management,fecal microbiota,multidrug resistant systematic infections,omics,one health
Decision-making framework and processes for holistic evaluation of environmental and climate policies. (DECIPHER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Greece,Belgium,France,United Kingdom,Austria,Germany,Netherlands,Spain
Call: Improved economic methods for decision-making on climate and environmental policies (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2613000.0
EU funding (EUR): 2613000.0
Participants: 12
Project status: SIGNED

The dual climate change and biodiversity crises put an urgency for implementing inclusive, just, and effective policies, while their inextricable nature calls for integrated assessment approaches that capture synergies and trade-offs. Mainstream economic methods currently used in the appraisal of environmental policies fail to capture the complexity of the climate-biodiversity-economy nexus. Even though uncertainty, disruption, and irreversibility are inherent to environmental challenges, these are overlooked when designing and evaluating the performance of policies. Policy effectiveness and resilience against other impact areas, such as quality of life, financial stability, political feasibility, innovation is not included in policy appraisal. Rather, policy evaluation is informed by a narrow set of metrics, falling short of encompassing broader considerations of sustainability and wellbeing. DECIPHER employs a systems and multi-disciplinary approach using a diverse set of models, methods, and processes to significantly improve decision-making on climate change and biodiversity and enhance policy resilience and feasibility. Moving beyond state-of-the-art, we will establish a holistic and operational decision-making framework that integrates advanced economic and biophysical models, empirical methods and stakeholder participation tools. The novel framework incorporates environmental damages in the economic decisions of agents and introduces a risk-opportunity approach for decision making. To offer critical insights on system dynamics and risks, the models developed will be equipped with innovative features including improved representations of agent behavior, technology innovation, financial risk valuation and the capacity to assess extreme events and critical tipping points. The new decision-making framework will be the end-result of an iterative co-creation process with stakeholders and applied under real-world conditions in the assessment of flagship EU policies.

Keywords: decision making framework,biodiversity,extreme events,system analysis,new economic theory,stakeholder co creation,cge,agent based model,macro econometric model,environmental policy assessment
Community-driven Healthcare Access and Mental Health Promotion for Inclusive, Equitable, and Resilient European Societies (EQUICARES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Belgium,Netherlands,Türkiye,Greece,Bulgaria,France,Ireland,Spain,Germany
Call: Access to health and care services for people in vulnerable situations (HORIZON-HLTH-2024-CARE-04-two-stage, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 6517230.68
EU funding (EUR): 5935974.33
Participants: 18
Project status: SIGNED

EQUICARES supports access to innovative and sustainable mental health and care services by people in vulnerable situations through a blend of research, co-creation and policy solutions. The project uses innovative methodologies, such as an advanced application of Levesque framework for evaluation of mental health services; the deployment of Computational Social Sciences to increase access for hard-to-reach populations in vulnerable situations and collect accurate quantitative and qualitative data on inequalities in mental healthcare services; and the combination of complementary cost-analysis techniques. To unlock the design of innovative solutions, the project maps, through digital ethnography, existing innovative solutions, analyses for accessible mental health services and links them with different parts of the mental health system. Such informative insights are visualised and offered to policy makers through a dedicated Atlas. EQUICARES pilots innovative solutions in 8 areas from 7 countries, which represent diverse socioeconomic settings and cover all major categories of vulnerable groups, while informing various strategic frameworks of EU. Through “Smart Health Labs”, the project engages vulnerable groups at the community level to co-design, implement and assess innovative solutions based on the principles of social economy and user innovation. At the individual level, the project provides awareness raising and capacity-building and pilots a novel AI-based Assistant, making advancements in the landscape of AI-generated mental health ecosystem, and fostering mental health and digital literacy of users. EQUICARES tests the value of its innovative solutions and applies novel cost analysis techniques to provide solid evidence on the negative impact on not taking measures. Finally,the project replicates its outcomes in 4 additional cases and develops the Inclusive Mental Health and Care Policy Dashboard towards the sustainability and policy uptake of its results.

Keywords: mental healthcare people in vulnerable situation computational social sciences ai based assistant solutions for enhanced care services access levesque framework co creation bottom up labs
Embedded AI Systems and Applications (ANT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Germany,Spain,Switzerland,Belgium,Italy,Austria,United Kingdom,United States
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 3817156.11
EU funding (EUR): 3699568.8
Participants: 22
Project status: SIGNED

Embedded Artificial Intelligence (AI) has emerged as a transformative technology with immense potential to revolutionise various domains, spanning from robotics and healthcare to environmental monitoring and the Internet of Things. This Doctoral Network (DN) project ANT aims to train a network of 15 excellent Doctoral Candidates (DCs) by addressing the fundamental challenges of Embedded AI and accelerating the development of Embedded AI systems and applications through an innovative and interdisciplinary research and training program. ANT consists of four interconnected Work Packages (WPs) that encompass different aspects of Embedded AI. WP1 tackles the challenges in designing low-footprint standalone Embedded AI models under resource constraints and with diverse contexts and evolving environments. WP2 goes beyond standalone Embedded AI and designs innovative distributed and scalable learning solutions for heterogeneous Embedded AI networks under energy and bandwidth constraints. WP3 enhances the trustworthiness of Embedded AI with explainability, robustness, security, and privacy. ANT concludes in WP4 with a concerted effort to transfer fundamental research contributions to industry-relevant applications in autonomous robotics, underwater IoT, mobile healthcare, and smart farming, boosting Europe’s position in the global AI market both from a talent and a technological perspective. These interdisciplinary and inter-domain research training, along with the comprehensive soft-skills training (spanning from presentation skills to intellectual property, marketing, and economics, etc.) will make ANT’s 15 DCs highly employable in various industries, academia, or public government bodies, and will position the EU at the forefront of the emerging revolution of Embedded AI on Things.

Keywords: embedded ai,tinyml,embedded systems,privacy,security,low footprint ai,trustworthy,autonomous robotics,underwater iot,mobile healthcare,smart farming