Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Cluster of Advanced Laser Light Sources (EUCALL)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Hungary,Sweden,Switzerland,Belgium,Romania,France,Czechia
Call: Implementation and operation of cross-cutting services and solutions for clusters of ESFRI and other relevant research infrastructure initiatives (H2020-INFRADEV-1-2014-1, 2014)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 7466800.0
EU funding (EUR): 7000000.0
Participants: 11
Project status: CLOSED

Advanced optical laser light sources and accelerator-based X-ray sources, as well as their technologies, scientific applications, and user communities, have developed independently over more than five decades. Driven by the developments at each optical laser and free-electron laser research infrastructures (RIs) in recent years, the gap between the optical laser and accelerator-driven light sources has diminished significantly. Both communities operate, implement, or plan advanced laser light source RIs, combining high-power optical and high-brightness X-ray light sources operated as dedicated user facilities. Operational and technical problems of these RIs have become very similar, if not identical. In specific cases, joint projects by the two communities have been initiated, but a closer and more structured collaboration of the corresponding communities and light sources is urgently required and shall be developed through this project. The present proposal for a European Cluster of Advanced Laser Light Sources (EUCALL) is the first attempt to create an all-embracing consortium of all (optical and X-ray) advanced laser light source RIs in Europe. Besides addressing the most urgent technical challenges, EUCALL will develop and implement cross-cutting services for photon-oriented ESFRI projects, will optimize the use of advanced laser light sources in Europe by efficient cross-community resource management, will enhance interoperability of the two types of light sources, will ensure global competitiveness, and will stimulate and support common long-term strategies and research policies for the application of laser-like short-wavelength radiation in science and innovation. The EUCALL consortium includes the three ESFRI projects ELI, European XFEL, and ESRF(up), several national RIs, and the LASERLAB-EUROPE and FELs OF EUROPE networks as representatives for the nationally operated optical laser and free-electron laser RIs.

Keywords: research infrastructures,advanced light sources
Matching CNS Lineage Maps with Molecular Brain Tumor Portraits for Translational Exploitation (BRAIN-MATCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2024-04-30
Duration (months): 60.0
Total project cost (EUR): 1999875.0
EU funding (EUR): 1999875.0
Participants: 1
Project status: SIGNED

Brain tumors represent an extremely heterogeneous group of more than 100 different molecularly distinct diseases, many of which are still almost uniformly lethal despite five decades of clinical trials. In contrast to hematologic malignancies and carcinomas, the cell-of-origin for the vast majority of these entities is unknown. This knowledge gap currently precludes a comprehensive understanding of tumor biology and also limits translational exploitation (e.g., utilizing lineage targets for novel therapies and circulating brain tumor cells for liquid biopsies). The BRAIN-MATCH project represents an ambitious program to address this challenge and unmet medical need by taking an approach that (i) extensively utilizes existing molecular profiles of more than 30,000 brain tumor samples covering more than 100 different entities, publicly available single-cell sequencing data of normal brain regions, and bulk normal tissue data at different times of development across different species; (ii) generates unprecedented maps of normal human CNS development by using state-of-the art novel technologies; (iii) matches these molecular portraits of normal cell types with tumor datasets in order to identify specific cell-of-origin populations for individual tumor entities; and (iv) validates the most promising cell-of-origin populations and tumor-specific lineage and/or surface markers in vivo. The expected outputs of BRAIN-MATCH are four-fold: (i) delivery of an unprecedented atlas of human normal CNS development, which will also be of great relevance for diverse fields other than cancer; (ii) functional validation of at least three lineage targets; (iii) isolation and molecular characterization of circulating brain tumor cells from patients´ blood for at least five tumor entities; and (iv) generation of at least three novel mouse models of brain tumor entities for which currently no faithful models exist.

Keywords: brain tumor,tumor biology,molecular characterization,liquid biopsies,single cell sequencing,neurodevelopment
Scalable, trustEd, and interoperAble pLatform for sEcureD smart GRID (SealedGRID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,Greece,Greece,Romania,Greece
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1080000.0
EU funding (EUR): 1080000.0
Participants: 6
Project status: CLOSED

The rapid evolution of ICT has revealed the potential for centrally monitoring, controlling, and optimising the power grid. In this context, a more intelligent, responsive, and efficient, system has been devised, known as the Smart Grid (SG). As explained in the EU Third Energy Package the SG will support a dynamic two-way information exchange between utility companies and their customers, contributing towards a smart and sustainable energy management in Europe and the establishment of a wiser energy consumption mentality. However, besides the benefits of such an endeavour, the power grid will be exposed to security threats inherited from the ICT sector, while privacy issues and new vulnerabilities, related to the specific characteristics of the SG infrastructure, will emerge. The problem is assessed as crucial, if we consider that a potential attack to the SG may lead to cascading failures, ranging from destruction of other interconnected critical infrastructures to loss of human lives. Thus, the development of a security platform tailored to the SG is required, that i) can efficiently manage the plethora of SG nodes, ii) deal with potential malicious hardware or software modifications due to the physical access of the customers to the SG nodes, and iii) operate over heterogeneous systems. Considering all the above, SealedGRID aims at bringing together experts from industry and academia from cross-sectorial research areas having complementary background with the long-term goal to design, analyse, and implement a scalable, highly trusted and interoperable SG security platform. The platform will combine, for the very first time, technologies like Blockchain, Distributed Hash Tables, Trusted Execution Environments, and OpenID Connect, while for its realization the SealedGRID consortium is committed to a fully-integrated and multi-disciplinary secondment programme combined with a set of networking, dissemination, and exploitation activities.

Keywords: key management,decentralized authentication,single sing on trust management,web of trust,blockchain,attribute based access control,distributed hash tables,security interoperability
Catalytic activity Enhanced meChanisms Of TRANSition metal decorated N-doped carbon by precursor acid treatment (EcoTrans)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-06-20
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Among the next-generation of energy technologies, fuel cells and air batteries show great potential to meet our growing energy demands. However, their overall efficiency is severely limited by the sluggish oxygen reduction reaction (ORR) at the cathode. So far, Pt-based materials are regarded as the ideal ORR electrocatalyst in practical applications because of the high catalytic activity and stability. However, the scarcity, high cost, and inferior long-term stability of Pt restrict its widespread application. The development of non-platinum group metals (non-PGM) earth-abundant alternatives with high activity and durability has been considered as a crucial task. A class of materials including transition metals and carbon-based compounds have been reported as the alternative catalysts to Pt for ORR, especially in proton exchange membrane fuel cells. Among them, the low cost electrocatalysts based on M-N (M, transition metal, such as Co, Fe and Ni) with carbon support (M-N-C) are the most studied. However, the relative low catalytic activity limited by the active cites, low catalyst utilization in practical electrodes because of the thick catalyst layer resulting from the high catalyst loading, and poor stability due to the leaching of transitional metals in real operation conditions are still big challenges in both fuel cells and metal-air batteries. In EcoTrans, the main purpose is to establish new knowledge of the enhancement mechanisms on catalytic activities of novel M-N-C catalysts prepared from acidic treated precursors and surface encapsulation by polymerized ionic liquids (ILs), and then based on the understanding to define the structure and synergistic effects between different elements to guide the development of low cost, highly active M-N-C based catalyst electrodes. The ambitious aim will be achieved with the complementary skills of the ER (N-C and transitional metal electrocatalysts) and supervisors (fuel cell electrodes and ILs).

Keywords: proton exchange membrane fuel cell,electrode,oxygen reduction reaction,electrocatalyst,ionic liquid
millimeter Wave Channel Modelling Considering Environmental Factors (mmChannel)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The Millimetre-wave (mmWave) frequency band offers wide available bandwidth for 5G and future wireless networks. However, due to the large propagation attenuation of the mmWave frequency, real-world environmental factors, including weather, foliage, humans, vehicles, have a significant impact on the channel path loss. In order to design and optimise 5G and future networks, a mmWave channel model considering the environmental factors is urgently required. In this project, we aim to equip a ray-tracing channel model with environmental factors in the mmWave band. The goal will be approached through 3 work packages (WPs). First, the ER will develop a parametric attenuation model by parameterising the environmental factors and integrate it with a ray-tracing simulation model. Second, the ER will acquire the channel data for each corresponding environment factor and extract parameters using machine-learning-based methods. Third, the developed channel model will be applied to evaluate and optimise mmWave wireless networks taking environmental factors into account. This project will be an extension of the ER’s previous work, which will develop him to be a mature researcher.

Keywords: millimetre wave,channel modelling,propagation modelling,channel measurement,machine learning
Networking the Educational World: Across Boundaries for Community-building (NEW ABC)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Innovation actions
Countries involved: Spain,Italy,Italy,Spain,Italy,Cyprus,Belgium,Finland,Poland,France,Portugal,United Kingdom,United Kingdom,Portugal
Call: Mapping and overcoming integration challenges for migrant children (H2020-SC6-MIGRATION-2020, 2020)
Start date: 2021-01-01
End date: 2024-08-31
Duration (months): 44.0
Total project cost (EUR): 3111896.25
EU funding (EUR): 3036657.0
Participants: 14
Project status: SIGNED

The overarching aim of NEW ABC is to take a transformative approach through a commitment to sustainable, strategic change by combining stakeholder voices, co-created and participatory practices, and the creation of synergies among stakeholders that do not normally interact. Despite the EU’s and national governments’ past and current efforts to devise a successful strategy for the integration of refugees and migrants in their new countries, research suggests that children with a recent past of migration continue to face barriers in the education system that current top-down policies fail to overcome. The NEW ABC project contributes to educational, cultural and social inclusion by taking a collaborative and participatory approach in the co-creation of nine innovation pilot actions aimed at enhancing the integration of immigrant children and young people in education through collaborative partnerships that foreground young person-led innovation activities. The pilot actions will be co-created with the specific aim of ensuring their adaptability, scalability, long-term sustainability and take-up of the results by the identified users. New ABC will take a transformative approach by ensuring: • the development of horizontal and vertical synergies of stakeholders, • an evidence-based, bottom-up approach in creating and piloting the nine innovation practices, • the empowerment and development of agency of vulnerable groups and other hard-to-reach stakeholders, • the continuous engagement of all voices throughout the project and after its completion, • the fall-out effect of such empowerment and agency on other aspects of their lives, • the uptake of the results and solutions offered by the pilot actions by policy- and decision-makers. The project will be implemented in 9 EU countries with 14 partners.

Keywords: bottom up approach,participatory action research,care and compassion migration,whole child approach
Novel piezoelectirc peptide-based scaffold for 3D cell culture (PiezoGel)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-04-01
End date: 2022-11-30
Duration (months): 20.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Tissue regeneration has emerged as a promising novel therapy for various disease conditions. A key requirement for the implementation of this advanced approach is the efficient, reliable and reproducible growth of 3D cell cultures, including organoid structures. State-of-the-art 3D culture media support the growth of such cultures, yet exhibit several key setbacks, including low reproducibility and limited modularity. Moreover, no commercial piezoelectric media are currently available, thus prohibiting the option of inducing electrical stimulation of the cells via mechanical stimuli, similar to the in vivo function of several tissues. Here, we aim to develop PiezoGel, a biocompatible, reproducible, controllable and piezoelectric medium for 3D cell cultures. The newly-designed medium will be based on two components, a cell-supporting hydrogel and a piezoelectric self-assembled peptide structure. In the scope of the BISON-694426 Advanced ERC project, we identified promising molecular building blocks for each of these components. The Proof of Concept project will focus both on technological development of the PiezoGel matrix and on business feasibility. Thus, the formulation of the newly-designed cell medium will be optimized, and the resulting matrix will be examined for various properties, including mechanical rigidity and piezoelectricity. The growth of diverse organoid cultures, as well as stem cell differentiation, will be further tested and calibrated. Relevant stakeholders will be approached allowing to map the product requirements and expected features directly from the users. In parallel, the regulatory compliance of the PiezoGel medium will be verified, and the relevant material and methodologies will be patented. We envision diverse applications for the PiezoGel technology, including establishing 3D cell cultures as drug development platforms, basic research exploration, and further advancement of the tissue regeneration field.

Keywords: tissue regeneration,3d cell culture,piezoelectric cell medium,organoids,peptide self assembly,hydrogel
Innovative materials and techniques for the conservation of 20th century concrete-based cultural heritage (InnovaConcrete)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Germany,Germany,Germany,Spain,Italy,Italy,Italy,Spain,Italy,Germany,Italy,Argentina,Spain,Greece,Greece,Poland,Switzerland,Greece,Poland,Belgium,Greece,France,Netherlands,United States
Call: Innovative solutions for the conservation of 20th century cultural heritage (H2020-NMBP-2017-two-stage, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 6916287.5
EU funding (EUR): 6882086.5
Participants: 34
Project status: CLOSED

InnovaConcrete is an innovative and ambitious proposal that aims at preserving concrete-based monuments, the most significant tangible Cultural Heritage (CH) in the 20th Century. To achieve this goal, we have recruited an interdisciplinary team presenting a strong scientific background in simulation techniques and nanomaterials synthesis, combined with a wide knowledge of CH conservation from Humanities disciplines and, a sound industrial perspective. Specifically, a completely innovative approach based on producing C-S-H gel, responsible for the engineering properties of cement paste in cracks of decayed concrete monument, in situ, will be developed. Complementary, other innovative solutions giving rise to superhydrophobicity and corrosion inhibition will be also investigated. In addition, InnovaConcrete will explore an approach based on biotechnology: enzyme-assisted self-healing of damaged surfaces. The optimization of the solutions proposed will be carried out by the use of theoretical tools (multi-scale modelling approaches) together with experimental tools (laboratory and in situ validation). Significant 20th century monuments, such as the spectacular building, Centennial Hall, the open-air sculptures of Eduardo Chillida, War Memorial Towers and concrete shell structures, typical construction in communist period will be used as case studies to validate the performance of the solutions proposed. These monuments, a clear representation of European CH, will be employed to study economic and other societal effects of the proposal and to promote citizens' awareness of 20th century European heritage. Finally, the activities required for the future commercialization of the InnovaConcrete products, including standardization, certification, life cycle assessment, scaling up and exploitation strategies will be carried out.

Keywords: historic concrete,consolidant,csh gel,superhydrophobic products,corrosion inhibitors,enzyme assisted self healing,multi modelling,modermism architecture
New insights into wheat meiosis: Crossover resolution in the absence of the Ph1 locus (Crossover control)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project ultimately aims to increase the crossover frequency in bread wheat (T. aestivum), which would result in a higher number of recombination events and would be a powerful tool for plant breeding. Thus the results of the proposed research are relevant to crop improvement as well as to human health. In the next 50 years, we will require as much wheat as has been produced since the beginning of agriculture. There are 1.5 billion dependent poor in the world, of which 300 million living in countries surrounding Europe are at risk of starvation in the future. Finding solutions to address the problems of wheat production will be a dominant topic in European plant science. Specifically, this project builds on the work of the host group on the Ph1 locus - the major wheat locus controlling the specificity of chromosome pairing and recombination, and which ensures high fertility. Future breeding strategies for wheat will require exploitation of diversity in wild relatives, and manipulation of the Ph1 locus will be a powerful tool to facilitate introgression of traits from these related species. Recent work in the host group has shown that Ph1 locus carries cdk2-like kinases, and that deletion of Ph1 increases protein phosphorylation levels, altering the homologue pairing specificity. A major objective of this project is to characterise the alterations in the phospho-proteome of the meiocytes that result from deletion of the Ph1 locus. Recent results from a group studying meiosis in C. elegans have also shown that meiotic pairing specificity and recombination depend on protein phosphorylation levels, suggesting that the mechanism underlying Ph1 may be quite general. During this project we will collaborate with the C. elegans researchers to explore the similarities between the two kingdoms.

Keywords: wheat,ph1 locus,crossovers,phosphorylation,nutrients