Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genomic and single-cell approaches to establish the molecular basis of stony coral resilience to climate change-related stressors. (CoralCellSeq)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-15
End date: 2024-07-14
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Scleractinian corals are the main builders of the marine reefs that provide a home to roughly a quarter of all marine species. In addition, their photosynthetic symbionts contribute to Earth’s oxygen, absorb CO2 from the atmosphere, and provide the coral host with most of its metabolic needs. Global changes drastically affecting ocean acidification and temperatures cause the breakdown of this symbiosis. This process is also known as coral bleaching, and it results in a mass decline in coral reefs. Despite the continuous efforts to study this phenomenon, our understanding of the bleaching process is so far limited. It is important to emphasize that different coral species, display distinct responses to stressors, with varying mortality rates following bleaching. Hence, in this action, I will utilize these differences in coral resilience (i) to characterize the cellular and molecular responses to stressors of three corals with different levels of bleaching resilience (Stylophora pistillata, Acropora millepora, and Oculina patagonica); (ii) to identify specific genes that might be key players in coral resilience, and (iii) to design and test pharmacological interventions to modulate coral resilience to thermal and acidification stress. To do so, I will expose corals to thermal and acidification stressors and use single-cell genomics approaches to measure and compare cell type-specific gene expression responses to stressors within and between species. These analyses will highlight candidate molecular pathways and cellular processes responsible for the high resilience of some of these species. Together, this project will provide a high-resolution molecular map of stony coral responses to climate change-related stressors, and it will help me, and others advance towards targeted interventions to ameliorate these effects.

Keywords: single cell atlas,non model organism
Towards High-Performance Thermoelectric Generators based on Two-Dimensional Conjugated Metal–Organic Frameworks (T2DMOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-07-31
Duration (months): 25.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

T2DMOF is targeted at offering an extremely skilled and promising emerging researcher with a PhD in Organic Chemistry and an outstanding track record a highest quality training through research in the cross-disciplinary, supra-sectoral, and burgeoning field of 2D electronic materials by developing a green solution to address the global challenge of energy generation. Thermoelectric generators can convert temperature differences directly into electrical voltages via the Seebeck effect. However, the currently used thermoelectric materials (inorganic/conducting polymers) have critical drawbacks, as they contain highly toxic elements, require high micro/nanofabrication costs, display limited stability, etc. T2DMOF aims to develop a novel class of two-dimensional conjugated metal–organic frameworks (2D c-MOFs) to overcome the above-mentioned challenges in conventional thermoelectric materials, while proposing reliable structure–property relationships to guide the design of next-generation MOF-based thermoelectric materials. The diversity of 2D c-MOF synthesis methods (film/powder) enables planar flexible or columnar array thermoelectric generators to be realized in view of different practical application scenarios. T2DMOF’s overall objective is to train the fellow to become a mature and independent top scientist and to prepare him for a leading position in academia or industry in Europe.

Keywords: organic thermoelectrics,conductive metal organic frameworks,charge transport,coordination polymers
Hybrid solid electrolyte for safer rechargeable sodium batteries with higher energy density (HySoBatt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: CLOSED

Electrification is one of major pathways to the decarbonisation of Europe’s transport and energy sectors, which will allow Europe to address the ambition to become the world first climate-neutral continent by 2050. Rechargeable batteries will help decarbonise transport sector and enable a higher uptake of renewable energy, and are therefore strategically important to Europe. The HySoBatt project aims to develop a hybrid solid electrolyte comprising aligned NASICON-type inorganic nanofiber networks embedded in sodium (Na) conducting polymer electrolyte, which can be used in rechargeable solid-state Na batteries and to markedly improve battery’s energy density and safety. Such solid-state Na batteries will be a promising, low-cost alternative to the current widely used lithium-ion batteries (LIBs), without the need for any Critical Raw Materials that may bring potential supply risks for upscaling. The low-cost and improved safety of solid-state Na batteries will also promote their wider adoption in the battery market in the future. The applicant has extensive hands-on experience in sodium-ion battery research, and he will be able to extend further the breath of his research and gain a holistic view about the R&D of rechargeable Na batteries. The host institution will arrange a number of training activities helping the applicant gain new competences and skills not only in scientific research but also in project management & reporting, proposal preparation, IP protection, and science communications. The proposed research is aligned with both the SRIA of Batt4EU and the national and the host institution’s strategies on batteries. Both the applicant and the host institution will benefit from the two-way knowledge transfer. All research and training actions will significantly enhance the applicant’s future career prospects, helping him move towards a higher career path after the project. The project results will be disseminated to different target groups.

Keywords: rechargeable sodium batteries,hybrid solid electrolyte,solid state batteries,electrospinning,materials characterization,electrochemical testing
Polymer mechanics via Function spaces (PolyFun)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-06-01
End date: 2031-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Polymers are three-dimensional, flexible materials composed of macromolecular chains interconnected by crosslinks, which are indispensable in everyday products. Accurate computation of these materials is crucial to avoid trial-and-error synthesis, thereby extending polymer lifetimes and minimizing production waste. To date, continuum mechanics is the only discipline capable of achieving large-scale multi-physics computation of polymers. However, complex mechanical behaviors of polymers present significant challenges, necessitating the development of unconventional continuum theories and advanced machine learning techniques. While the former facilitates the capture of both local and nonlocal behaviors of polymers, the latter ensures model reliability by utilizing rich information from large datasets. Unfortunately, current machine learning approaches, when coupled with immature continuum theories, suffer from limited interpretability and an ad hoc nature. This underscores the need for a theoretically grounded machine learning approach to drive genuine advance in human knowledge. PolyFun aims to enable machine learning not only to recognize pattern, but also to develop a deeper understanding of data through the principles of continuum mechanics and polymer physics. This will be achieved by representing polymers as reproducing kernel Hilbert spaces and defining their structural and topological properties via these physical insights. PolyFun consists of two stages. Stage 1 focuses on learning from polymeric data and the domain knowledge of continuum and polymer mechanics. Stage 2 extrapolates understanding gained in Stage 1 to learn from real-world data and further enhance the computational scalability of the methodology. PolyFun’s unique perspective serves as a unified scientific language that bridges various disciplines (polymer physics, continuum mechanics and machine learning), fundamentally transforming the way we study and research in continuum interdisciplinary mechanics.

Keywords: continuum mechanics polymer physics mechanoluminescence damage strain induced crystallization phase transition reproducing kernel hilbert space machine learning
Scientific Training for Post-Translational Modification Detection in Cancer Screening (STRIM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark,Ireland,Spain,Norway,Germany,Netherlands
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3779245.03
EU funding (EUR): 3651638.4
Participants: 13
Project status: SIGNED

Cancer remains one of the greatest challenges to the EU healthcare systems. Early detection and diagnosis dramatically increases the prospect of successful treatment and survival. Academia and the rapidly growing cancer diagnostics and biosensors sectors have an urgent need for researchers skilled in developing improved screening technologies, which can offer major opportunities to impact cancer survival. However, the development of assays with the required sensitivity, reliability and technology formats for multi-cancer early detection is only recently emerging and faces significant R&D challenges. STRIM will train a cohort of researchers in the multi-disciplinary science, bioinformatics, technology, social, clinical and health-economic skills required to deliver comprehensive bioelectronic tools for cancer screening, tools that are fast, accurate, sensitive, and exploit advanced molecular receptors and nanobiotechnologies for detection of aberrant post-translational modifications (PTM) of proteins and nucleic acids as cutting-edge biofluid markers for early detection of cancers. Growing evidence suggests that PTM play important roles in human cancers and are likely to prove highly specific for cancer type. Focusing on both genomic and proteomic PTM biomarkers will be a game-changing strategy for improving early cancer detection rates, efficiency and population health. Doctoral training in STRIM will encompass state-of-the art approaches for ultra-sensitive detection of PTM biomarkers as cancer screening tools by building on recent advances in electrochemiluminescence, aptamer and DNA microarrays and conducting polymer micro-structured electrodes. These techniques will reach new levels of specificity and overcome barriers to the realization of multiplexed diagnostics for enhanced cancer screening. All translational issues will be considered in harmonization with regulatory and health technology assessment and social acceptability will be screened in the population.

Keywords: biosensors microarrays electrochemiluminecence field effect transistors bioinformatics aptamers cancer diagnostic aberrant post translational modifications health technology assessment
Diagnostic HER2DX-guided treatment for patients with early-stage HER2-positive breast cancer (DEFINITIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Austria,Italy,Switzerland,France,Germany,Ireland,Israel,Slovenia
Call: Pragmatic clinical trials on minimally invasive diagnostics (HORIZON-MISS-2023-CANCER-01, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 7999930.0
EU funding (EUR): 7999930.0
Participants: 19
Project status: SIGNED

HER2+ breast cancer affects around 390.000 women annually worldwide (i.e. 3 patients every 4 minutes). Over the last decade, polychemotherapy and HER2-targeted therapies have improved patient´s survival; however, the reality is that most patients are cured with less intense, toxic, and costly drugs. Up to now, no diagnostic test existed to guide the optimal therapy for each patient. The 27-gene HER2DX test (TRL8) is a novel minimally invasive diagnostic tool which provides unprecedented predictive information for therapy optimization in early-stage HER2+ disease. The DEFINITIVE project will prospectively validate HER2DX`s clinical effectiveness, proving its ability to significantly i) reduce toxicities, ii) improve quality of life and ii) reduce direct and indirect costs, while maintaining efficacy endpoints and survival outcomes in patients with early HER2+ breast cancer. DEFINITIVE will combine international experts in breast cancer from international reference hospitals, comprehensive cancer networks, regulatory, HTA and medical statistics experts, SMEs, policy makers, patient associations, living labs and medical society networks. DEFINITIVE consortium will conduct a pragmatic clinical trial across 44 centres in 7 European and associated countries to randomize 304 patients with stage II to IIIA HER2+ breast cancer, in a 1:1 manner, and to be treated with the result of the HER2DX test to guide treatment vs without the result of the test (treatment by physician´s choice according to local guidelines). The inclusion and exclusion criteria will be very broad to make sure that most patients can participate in the trial and the results could be generalized to the overall population treated in real-world settings. Beyond seeking the endorsement and implementation of HER2DX diagnostic test by clinical guidelines and healthcare systems, DEFINITIVE will boost the incorporation of affordable non-invasive diagnostic tools in the field of genomics and precision oncology. This action is part of the Cancer Mission cluster of projects on ‘‘Diagnostics and Treatment (diagnostics)”.

Keywords: breast cancer,her2,genomics,de escalation,immune,trastuzumab,quality of life,health technology assessment,cost effectiveness
Advanced toolkits for interdisciplinary and enhanced study, conservation, and restoration in burial excavations and findings (EXCALIBUR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: Greece,Netherlands,Germany,Italy,Cyprus,Bulgaria,Switzerland
Call: A European Collaborative Cloud for Cultural Heritage – Innovative tools for the study, conservation and restoration of heritage objects (HORIZON-CL2-2024-HERITAGE-ECCCH-01, 2024)
Start date: 2025-10-01
End date: 2029-03-31
Duration (months): 42.0
Total project cost (EUR): 4192573.76
EU funding (EUR): 3995408.13
Participants: 14
Project status: SIGNED

The Cardinal Objective of the EXCALIBUR project proposes a holistic framework that offers innovative tools and methods for enhanced study, improved conservation and restoration works, and knowledge of cultural heritage objects, based on their digital twins. EXCALIBUR focuses on solutions that assist the study, conservation, and restoration of burial excavations, remains, and findings at the level of (a) burial sites, excavations, and surroundings, (b) tomb structures and burial decorations, (c) artefacts, burial findings, traditions and ceremonies, and (d) human and burial remain. Through the centralised, interoperable, and human-based platform of EXCALIBUR, toolkits of usable, open-source, and cost-affordable solutions will be available for the wide spectrum of cultural heritage. The DNA of EXCALIBUR consists of the real user needs, as archaeologists, bioanthropologists, museologists, conservators, historians, researchers, and scholars co-define the requirements and their needs, co-design the toolkits, test, evaluate, and validate the tools through representative case studies and an open call for support to third parties, and finally using, the innovative and enhanced solutions of the project through the ECCCH. In addition, a multidisciplinary group of experts and sciences from European research, academia, and creative entrepreneurship join their forces, sharing their knowledge, designing and developing through cutting-edge technologies, and delivering breath-taking, but at the same time usable, cost-affordable, and sustainable solutions for enhanced study, improved conservation and restoration works, and knowledge of cultural heritage. The holistic framework and the innovative solutions of the EXCALIBUR project will be designed and developed according to the guidelines of the ECCCH infrastructure and services, as well as with close collaboration with the ECCCH ecosystem. Training, open call, communication, dissemination, and exploitation activities are included.

Keywords: digitisation,burial cultural heritage,digital twins,combined representations,extended reality,ct scans,study,conservation,restoration
Ultra Novel and Innovative Fully Integrated Engine Demonstrations (UNIFIED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: United Kingdom,Germany,France,Netherlands,Norway,Spain
Call: Ground Test Demonstration and Preparation of Flight Test of an Ultra High Bypass Ratio Ducted Geared Turbofan Engine for SMR Aircraft (HORIZON-JU-Clean-Aviation-2025-01, 2025)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 89689405.66
EU funding (EUR): 64115151.57
Participants: 19
Project status: SIGNED

The journey to climate-neutral aviation will require the power density of an ultra-efficient gas turbine combined with SAF, all highly integrated into an advanced aircraft platform for the SMR aircraft category. As the Clean Aviation SRIA states, this SMR aircraft category generates approx. 50% of the current share of air transport emissions, demonstrating the importance of the focus that is required on propulsion technology. The UNIFIED project will develop and demonstrate UltraFan®, a high performance scalable UHBR ducted turbofan to a TRL5 maturity level, targeting a 20% fuel reduction for SMR aircraft anticipating 2035 EIS. This TRL5 will be achieved via the project enabling technologies and enhancing design to deliver a full engine ground test at SMR thrust class. UNIFIED will importantly progress readiness for UltraFan Flight Test Demonstration including flight test vehicle design, flight test instrumentation and engine flight clearance readiness. Within this preparation, testing of the UltraFan Key Architecture will be conducted to generate evidence for Flight clearance. In parallel to the focus on demonstration and flight test preparation UNIFIED will create strong foundations for EIS. The consortium looks forward to working with EASA, progressing the CRL of the UltraFan architecture and technologies. Also, engagement with Lufthansa Technik will provide strong insight on the MRO aspects that will be critical to the successful deployment of UltraFan into the SMR sector. The activities of UNIFIED, led by Rolls-Royce, will bring airframer, suppliers, academics and research centres all strongly integrated within the UltraFan Programme. Synergies will be leveraged with the comprehensive national and regional programmes across the consortium that enable technology maturity at all levels. All with the objective to demonstrating that UltraFan is the most capable and credible engine architecture solution to meet SMR requirements and readiness for EIS 2035.

Keywords: ultrafan,full engine ground test,smr,ultra efficient gas turbine,saf,mro
Integrating behavioural insights and machine learning for smarter regulatory interventions (BEHAVREG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-11-01
End date: 2027-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Effective regulatory decision-making is essential for addressing complex societal challenges, yet current approaches often rely on intuition and standardized solutions that fail to account for behavioral, cultural, and contextual factors. BEHAVREG will transform regulatory governance by developing an innovative decision aid tool that integrates machine learning with behavioral science to predict likely compliance outcomes of regulatory choices and enable more effective intervention design. This project leverages comprehensive datasets, including ex-ante impact assessments and post-implementation reviews, to develop sophisticated predictive models that assess intervention effectiveness across diverse contexts. The tool analyzes critical factors such as compliance costs, social control mechanisms, institutional trust, and cultural norms to provide nuanced recommendations that move beyond binary regulatory choices. BEHAVREG's machine learning algorithms, trained on structured historical data, will identify patterns to improve prediction accuracy and evaluate regulatory trade-offs. This will empower regulators to select appropriate interventions—whether mandates, incentives, nudges, or information campaigns—precisely tailored to specific regulatory environments. Importantly, the system can predict potential backfire effects and unintended consequences, enabling regulators to anticipate challenges before implementation. By bridging the gap between theoretical insights and practical implementation, BEHAVREG delivers evidence-based predictions and actionable recommendations. This innovation will optimize regulatory design across sectors and cultures and will improve compliance outcomes, reduce enforcement costs, and enhance public trust—representing a significant advancement in regulatory governance with global implications for policy development and implementation.