Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microbial therapy against gut inflammation (MAGI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Gut microbiota support intestinal tract development, immune system maturation, and protection against pathogens. Imbalanced microbiota (dysbiosis) has a role in inflammatory bowel disease (IBD). To control inflammation, patients take antibiotics, exacerbating dysbiosis, leading to loss of colonization resistance against pathogens and proliferation of pathobionts, disease development and progression. Microbiota composition has, therefore, a very important role in host health, and strategies to manipulate this composition are lacking. Microbiota-produced molecules, like quorum sensing (QS) signal autoinducer-2, can influence gut composition. Bacteria use QS to regulate populational gene expression. We intend to take advantage of microbial interactions mediated by QS to tackle IBD dysbiosis. We will design biotherapies to attenuate the detrimental dysbiotic effects on host health, focusing on gut QS in IBD. The microbiota imbalance observed in IBD leads to high inflammation, expansion of pathobionts, and loss of protection against infections. In previous work, we have shown that by committing the gut microbiota to inter-species QS we could increase members of the microbiota affected by antibiotics, highlighting the potential of QS manipulation to counteract dysbiosis. We propose to manipulate QS of native gut microbes to counteract IBD-associated dysbiosis, and thus inflammation and loss of protection associated with it, rescuing normal microbiota functions. We will tackle dysbiosis by manipulating QS signalling and by fostering specific beneficial interactions amongst microbes. The potential of this therapy, as an alternative or complement to antibiotics, is centred on bypassing the worsening of dysbiosis, like loss of protection against the expansion of inflammation-driving pathobionts and infections, as well as the attenuation of inflammation.

Keywords: quorum sensing,inflammatory bowel disease,microbiota,microbial interactions,disease
'Living' Colloidal Liquid Crystals ([LC]2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 1402345.0
EU funding (EUR): 1358083.65
Participants: 2
Project status: SIGNED

We propose an unprecedented class of soft, self-assembled and self-motile micro-machines. The combined qualities of active fluids and colloidal liquid crystals can be leveraged to design intrinsically out-of- equilibrium hierarchal structures, or ‘Living’ Colloidal Liquid Crystals [LC]2. The study of colloidal interactions and self-assembly in active nematics has yet to be considered and constitutes an unexplored and inter-disciplinary application of the emerging sciences of active matter and colloidal liquid crystals. Activity will endow dynamical multi-scale colloidal structures with autonomous functionality, including self-motility, self-revolution and dynamical self-transformations, which are exactly the characteristics one would desire for a first generation of autonomous components of micro-biomechanical systems and soft micro-machines. As hybrids between biological active fluids and man-made materials, [LC]2 structures represent an early foray into ‘living’ metamaterials, in which active self-assembly of simple components produces a rich diversity of behaviours and the potential for autonomously tunable material properties, mimicking biological complexity. In particular, we hypothesize self-assembled [LC]2 dimer turbines, colloidal flagella and ant-like group retrieval. These systems represent a fundamentally innovative concept that we propose to drive nanotechnology into a new future of soft materials that biomimetically self-assemble and autonomously enact functions. It is our multiscale coarse-grained simulations and expertise in flowing active nematic fluids that generates the opportunity for this unique line of research.

Keywords: active matter,colloids,liquid crystals,self assembled materials,biomaterials
Search for the scalar glueball in a coupled channel amplitude analysis of J/psi decays with the BESIII experiment (Glueballs at BESIII)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 246669.12
EU funding (EUR): 246669.12
Participants: 2
Project status: SIGNED

We propose to search for the scalar glueball, an exotic particle consisting entirely of the gauge bosons of the strong interaction, the gluons, using ten billion decays of the charmonium state J/psi recently accumulated with the BESIII experiment. The existence of glueballs has been predicted by the theory of the strong interaction, quantum chromodynamics (QCD), four decades ago. Yet, to date there has not been experimental evidence. Exploiting the unprecedented statistics of the BESIII experiment in combination with modern day high performance computing, we aim to uncover the glueball in a complex coupled channel amplitude analysis of J/psi decays into final states containing a vector particle and two pseudoscalar mesons. While radiative decays present a favourable, gluon-rich environment, massive vector mesons act as a flavour filter for an intermediate scalar resonance that subsequently decays to the two pseudoscalar mesons. Combining the information from these different decay channels in a coupled channel amplitude analysis will allow us to investigate the glueball components of the five established scalar states and by this the existence of the glueball itself. Our proposed work will, thus, address one of the pressing questions of QCD. To achieve our goal, we will develop a framework combining state-of-the-art amplitude analysis in K-matrix formalism with high performance computing on graphics processing units and will furthermore strongly collaborate with the Joint Physics Analysis Center hosted at Indiana University. The knowledge acquired during the outgoing phase, regarding the physics topic of the proposal, advanced aspects of amplitude analysis and a general purpose, high performance computing framework for such studies will be transferred back to Europe during the returning period. It will directly benefit ongoing research efforts at Johannes Gutenberg Universität Mainz as well as upcoming particle physics experiments like PANDA at FAIR hosted in Europe.

Keywords: hadron spectroscopy,partial wave analysis,charmonium decays,exotic states,strong interaction,scalar meson,glueball,k matrix formalism,coupled channel analysis,gpu computing,besiii experiment
The neurobiological and computational origins of behavioral variability (learNoise)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Human behavior is inherently variable. Even when faced with the same exact choice options, we often take different actions. The causes for this inconsistency are unknown, but economic and cognitive theories assume this is due to noise that is injected when making a decision. However, I have recently demonstrated that noise might not just arise during the decision process, but that the learning process itself (i.e update of internal representations based on feedback) is subject to substantial and meaningful noise. Concretely, I have shown that noise during learning accounts for the majority of what is traditionally reported as ‘decision noise’. However, the neural mechanisms underlying this learning noise remains unknown. In this fellowship, I will examine the contributions of the locus coeruleus-noradrenaline (LC-NA) system to this learning noise. NA has previously been associated with decision noise and here I will test whether activity in the LC is the driving factor behind learning noise. I will use a cutting-edge real-time fMRI framework that allows to causally test whether ongoing LC activity directly influences learning noise. Moreover, I will examine whether this learning noise is relevant to impulsivity, which has previously been implicated in decision noise. This fellowship has the potential to overthrown the traditional view on behavioral variability in decision making and will provide a novel neurobiological, computational and psychiatric grounding for understanding why humans are consistently inconsistent.

Keywords: behavioral variability,locus coeruleus,learning imprecision,computational modeling,real time fmri,computational psychiatry
Science in the City (SitC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland,Malta
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-07-01
End date: 2021-05-31
Duration (months): 11.0
Total project cost (EUR): 142835.0
EU funding (EUR): 100000.0
Participants: 4
Project status: CLOSED

Science in the City is a Science and Arts Festival. Malta's Capital City, Valletta, on ERN is filled with researchers from all scientific fields, experiments, performances, art installations, games and much more to attract some 30,000 people. This EFFE award winning, national event has been visited by 42% of Malta's population at least once over the past 8 years. It educates, enthralls and excites people of all ages. It inspires creativity, nurtures curiosity and a passion for knowledge in children, youth and adults across the country. The festival supports the idea of RRI and uses its activities to explain the concept and bring researchers closer to the publics.

Keywords: engagement,enable empower,science,researchers,careers,arts,creativity,education,active citizens
Heterogeneous Secure Multi-level Remote Acceleration Service for Low-Power Integrated Systems and Devices (RAPID)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Spain,Spain,Türkiye,Greece,Greece,United Kingdom
Call: Advanced Cloud Infrastructures and Services (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 2023800.0
EU funding (EUR): 2023800.0
Participants: 8
Project status: CLOSED

Many low-power devices such as smartphones, tablets, notebooks as well as several other embedded systems can't always cope with the increased demand for processing power, memory and storage required by modern applications in gaming, vision, security, robotics, aerospace, etc. As a result, most such applications are only executed on high-end servers. RAPID tackles this challenge by taking advantage of high-performance accelerators and high-bandwidth networks. Following our approach, compute or storage intensive tasks are seamlessly offloaded from the low-power devices to more powerful heterogeneous accelerators, supporting multiple virtual CPUs and GPUs. We propose, for the first time, a secure unified model where almost any device or infrastructure, ranging from smartphone, notebook, laptop and desktop to private and public cloud can operate as an accelerated entity and/or as an accelerator serving other less powerful devices in a secure way. RAPID offers a registration mechanism, which permits the accelerated entities to automatically find and connect to nearby accelerators with the required resources. Next, a runtime system, running on each such accelerated entity, takes into account several parameters such as the local status, the environmental conditions, the task requirements, and the status of the accelerators it is connected to in order to decide whether local tasks (or incoming tasks if the entity also acts as an accelerator) should be executed locally or remotely. Novel scheduling algorithms, admission control policies, Service Level Agreements and license policies are employed to serve multiple accelerated applications efficiently on heterogeneous cloud infrastructures. An easy-to-use task-based programming model will be defined, while a novel runtime will automatically offload and execute the tasks transparently to the programmer. Within the RAPID project the first public acceleration cloud service will become available and commercially exploitable.

Keywords: mobile cloud computing,heterogeneous cloud,acceleration,runtime system,mobile devices,parallel programming model,robotics,kinect camera
Quantum Optomechanics with a levitating nanoparticle (QnanoMECA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Spain,Switzerland
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2020-09-30
Duration (months): 60.0
Total project cost (EUR): 1987500.0
EU funding (EUR): 0.0
Participants: 2
Project status: CLOSED

Micro- and nano-mechanical oscillators with high quality (Q)-factors have gained much interest for their capability to sense very small forces. Recently, this interest has exponentially grown owing to their potential to push the current limits of experimental quantum physics and contribute to our further understanding of quantum effects with large objects. Despite recent advances in the design and fabrication of mechanical resonators, their Q-factor has so far been limited by coupling to the environment through physical contact to a support. This limitation is foreseen to become a bottleneck in the field which might hinder reaching the performances required for some of the envisioned applications. A very attractive alternative to conventional mechanical resonators is based on optically levitated nano-objects in vacuum. In particular, a nanoparticle trapped in the focus of a laser beam in vacuum is mechanically disconnected from its environment and hence does not suffer from clamping losses. First experiments on this configuration have confirmed the unique capability of this approach and demonstrated the largest mechanical Q-factor ever observed at room temperature. The QnanoMECA project aims at capitalizing on the unique capability of optically levitating nanoparticles to advance the field of optomechanics well beyond the current state-of-the-art. The project is first aimed at bringing us closer to ground-state cooling at room temperature. We will also explore new paradigms of optomechanics based on the latest advances of nano-optics. The unique optomechanical properties of the developed systems based on levitated nanoparticles will be used to explore new physical regimes whose experimental observation has been so far hindered by current experimental limitations.

Keywords: optomechanics
Key enabling manufacturing technology for low-cost and sustainable production of fibre-based rigid packaging at scale (YANGI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-04-01
End date: 2023-12-31
Duration (months): 33.0
Total project cost (EUR): 2848627.5
EU funding (EUR): 1994039.25
Participants: 2
Project status: SIGNED

Plastic is widely known as one of the most significant and rapidly growing sources of industrial waste, with the EU alone estimated to generate 25.8 Mt of plastic waste every year (58 kg/person). Packaging is the main use of plastic, accounting for 60 % of the total plastic waste in the EU. Worldwide, governments are prohibiting and taxing the use of single-use plastics, setting high pressure on the packaging industry to shift to sustainable materials. Cellulose (fibre-based) materials are a promising alternative that can replace plastics in most of rigid packaging products in a 1:1 ratio without compromising quality. However, the high costs of their current production processes have prevented packaging producers and brands from substituting plastics with fibre-based materials at a commercial scale. The Loop Factory has developed Yangi, the world’s first manufacturing machine to unlock a true substitute to plastic in rigid packaging: low-cost, 3D fibre-based packaging production at scale. At the heart of its innovation there is an efficient process consisting of one-step production line that consumes considerably less resources and time than existing two-step production methods. In comparison, Yangi uses 85% less water which minimises the energy needs with 75%. This allows for a faster, cheaper and scalable production claiming 80% less factory space and half of machinery costs. Yangi makes it possible for cellulose to finally compete with plastics in low-cost, high volume segments. The EIC accelerator project will setup a demonstration plant to run customer pilots in 4 packaging applications and show their results to additional stakeholders. We will establish a scalable manufacturing and distribution partnership with a global machine supplier and secure IP for market release and scale up. With 77 machines in operation by 2030, our technology is expected to save more than 190 000 tons of plastic waste, 11 Bn litres of fresh water and 260 000 tons of CO2.

Keywords: circular economy,sustainable packaging,plastic waste,recycling,fibre based packaging
Biopolymers with advanced functionalities for building and automotive parts processed through additive manufacturing (BARBARA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Italy,Germany,Spain,Spain,Italy,Spain,Sweden,Belgium,Belgium
Call: Biopolymers with advanced functionalities for high performance applications (H2020-BBI-JTI-2016, 2016)
Start date: 2017-05-01
End date: 2020-10-31
Duration (months): 42.0
Total project cost (EUR): 2711375.0
EU funding (EUR): 2603861.25
Participants: 12
Project status: CLOSED

The project aims at the valorisation of side-stream fractions and residues from agro-food production into novel polysaccharides and functional additives. These raw materials have been selected based on the advanced functionalities that provides to the polymeric matrixes. The extracted polysaccharides will be compatibilised with polyesters and polyamides and reinforced with extracted, modified and functionalised additives to obtain engineering bioplastic formulations adapted to current Fused Filament Fabrication (FFF) processes. The target of BARBARA project is the development of novel bio-based engineering bioplastic materials to validate in functional prototypes with advanced properties for building and automotive sectors. The main functionalities developed under the BARBARA approach will permit the improvement of mechanical, thermal, aesthetical and well-being properties of novel biobased engineering polymers. Selected demonstrators of direct final parts for the automotive sector and moulds and tools for hybrid manufacturing for advanced building applications. Innovations in FFF will be validated during the project in order to enhance the performance of BARBARA biobased materials through this technology and fulfil the high-requirements of the industrial sectors. BARBARA project will directly contribute to achieve SIRA´s objective in KPI 5 (4 new advanced biobased materials) and KPI 6 (3 validated consumer products through 2 novel value chains for FFF). The BARBARA consortium involves 11 partners (5 RTD, 3 SME and 3 Large Companies) accounting to 1 BIC full member, 1 in process of engaged and 3 associated, in 36-months project with a budget of 2,770,750€.

Keywords: additive manufacturing,fused filament fabrication,agrowaste revalorization,polyssacharides,natural dyes,functional additives,automotive,building,hybrid manufactring,rtm mould