Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fighting Anxiety with Importin-based Therapeutics (FAITh)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-11-01
End date: 2019-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Anxiety and stress-related conditions represent a significant health burden in modern society. Anxiety disorders are currently treated with a variety of agents targeting synaptic mechanisms. These agents either directly affect neurotransmitter receptor systems or modulate neurotransmitter levels or availability, but their long-term use is limited by problematic side effects and suboptimal efficacy. The development of new anxiolytic drugs has been fraught with difficulty, hence there is a need for new targets and new avenues for therapeutic development. Importin-dependent transport mechanisms link synapse to nucleus in a diversity of physiological contexts, rendering them potentially interesting targets for behavioural control. However importins and related molecules have not been evaluated for roles in anxiolysis to date. We discovered the roles of importins in axonal injury signaling and in cell size sensing. During the course of our current ERC Advanced grant, and as part of one of the aims, we have conducted comprehensive phenotyping of importin mouse mutants to identify in vivo consequences of the deregulation of size control pathways. One importin mutant line presented a specific phenotype in anxiety tests, and follow-up analyses identified a new molecular pathway for anxiety regulation, and approved drugs affecting this pathway that can be repositioned for anxiety treatment. In this PoC, we will (1) carry out IP protection on our initial identifications of anxiolytic drugs; (2) further validate the anxiolytic activities of these drugs and their closely related structural or functional analogs; and (3) devise an HTS-compatible assay for targeting the importin involved and conduct a pilot screen of ~200,000 compounds in this assay to identify new drug leads for anxiety treatment. As a final step, we will carry out (4) additional IP protection and pre-commercialisation tasks for maximizing the commercialisation potential of our discovery.

Keywords: anxiety,anxiolysis,drug discovery
Building Research environments for fostering Innovation, Decision making, Governance and Education to support Blue growth (BlueBRIDGE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Greece,Greece,Norway,Greece,France,France,France,France,Denmark,United Kingdom
Call: e-Infrastructures for virtual research environments (VRE) (H2020-EINFRA-2015-1, 2015)
Start date: 2015-09-01
End date: 2018-02-28
Duration (months): 30.0
Total project cost (EUR): 5295753.75
EU funding (EUR): 5295753.75
Participants: 14
Project status: CLOSED

BlueBRIDGE responds to the Juncker Investment Plan opening funding opportunities for e-Infrastructures, innovating current practices in producing & delivering scientific knowledge advice to competent authorities & enlarges the spectrum of growth opportunities in distinctive Blue Growth areas. BlueBRIDGE builds on existing EU and International e-Infrastructures providing capacity building in interdisciplinary research communities of scientists, data managers & educators in academic institutions & industries focusing on 4 major challenges: 1) stock assessment 2) socio-economic performance analysis in aquaculture 3) fisheries & habitat degradation monitoring 4) education & knowledge bridging on protection & management of marine resources. BlueBRIDGE capitalizes on past investments and uses a proven e-Infrastructure connecting 1500+ scientists, integrating +50 repositories, executing +13,000 models & algorithms/month; providing access to over a billion quality records in repositories worldwide, with 99,7% service availability. BlueBRIDGE focuses on user needs, opening services & data to actors & liaising with competent agencies & SME Innovation Clusters. Major results include service-driven research environments addressing concrete challenges, data and a wide range of user defined Blue Growth indicators. BlueBRIDGE leverages a set of common services that together foster the realization of an innovative infrastructure-based approach for collaborative knowledge and data sharing, publishing, citation, traceability & trust concretely contributing to the e-Infrastructure Commons. BlueBRIDGE will be deployed in 30 months by an authoritative & complementary consortium with expertise in multiple scientific domains. It bundles forces from International Government Organizations, research institutes, industry, SMEs, education and computer science domains, establishing a network with a proven track in VREs & e-Infrastructures, marine, environmental & fisheries science & economy.

Keywords: data publishing,hybrid data infrastructure
CAPTURING AND REPRODUCTION OF CROWDED ACOUSTIC ENVIRONMENTS FOR IMMERSIVE APPLICATIONS (CROWDMERSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2021-02-28
Duration (months): 36.0
Total project cost (EUR): 254457.0
EU funding (EUR): 254457.0
Participants: 3
Project status: CLOSED

CROWDMERSE enables real-time capture, processing, and reproduction of an immersive audio experience to the user of any event of interest, focusing on “crowded” acoustic events. Acoustic scenes with large audiences, such as sports events or music concerts, present significant challenges for immersive reproduction which have not been so far adequately considered in the signal processing community. Technological breakthrough in sports events broadcasting has a strong potential impact on media providers, and consequently on the European and global economy. The challenges of capturing and reproducing crowded acoustic events include the need to spatially capture and reproduce numerous sound sources, such as the applause and yells of the spectators, in addition to the “main” sounds of the event. Concerns regarding the privacy of the spectators must not be overlooked: the conversations of the audience members sitting near the microphone sensors must be eliminated. In order to spatially sample large venues, the acoustic sensors should be low-cost, small-sized, and support wireless operation. The developed algorithms should respect the limited sensor resources, while operating in real-time to enable commercial applications. Our final objective is to enable real-time delivery of crowded acoustic events so that the designed platform can be integrated with today’s High-Definition TV programs. CROWDMERSE focuses on sound capturing using multiple closely placed microphones forming a microphone array. The audio content is rendered through a home entertainment system equipped with multiple loudspeakers, accompanying the content of a typical HDTV broadcast. Addressing the scientific challenges and proposing a solution which can be integrated with current broadcasting principles is guaranteed given the previous involvement of the experienced researcher in sports broadcasting projects. The proposed methods are expected to have impact in the general area of immersive sound environments.

Keywords: spatial audio,microphone arrays,immersive audio
Doctoral Industrial School on Human Skin models for Staphylococcal infections (DISSection)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Netherlands
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-11-01
End date: 2020-10-31
Duration (months): 48.0
Total project cost (EUR): 1026871.2
EU funding (EUR): 1026871.2
Participants: 2
Project status: CLOSED

Staphylococcus aureus (S. aureus) is a major human pathogen and cutaneous infections are among the leading cause of emergency department visits. Unfortunately, S. aureus vaccine development is hindered by the lack of known correlates of protection. Three dimensional organotypic human skin models may represent a valid alternative to animal infection model. Indeed, S. aureus expresses several human-specific virulence factors. However, at the present such models have been rarely used in the S. aureus research field and, to our knowledge, never with immune-competent models. Therefore, a major aim of this proposal is to develop a human skin equivalent and integrate key immune components in the epithelial matrix. To accomplish this goal we will take advantage of cutting-edge technologies, such as induced pluripotent stem cells to generate macrophages and neutrophils. The model will be used and optimized to the following main objectives: better understanding of human-specific pathogenesis of S. aureus as well as protective mechanisms against the pathogen; development of the first immune-competent human skin models for vaccine research; determine the role of bacterial communities on skin infections; provide alternative methods to animal models. The proposed scientific program will be complemented with a number of training courses based on specific skills for which both the University of Utrecht and Novartis Vaccines are renowned. Complementary courses on dermatology, human skin infections, hydrogel scaffolds, mass spectrometry, and induced pluripotent stem technology, will be held by associate partners. At the end of the project the students will receive a PhD degree in the area of Infection and Immunity. We believe that this project is at the leading edge of science and technology and represents a good opportunity for students that are willing to grow both in basic science as well as innovative and applicative research.

Keywords: human skin equivalents,tissue engineering,s aureus,phagocytes,immune evasion,complement,predictive models,correlates of protection,mass spectrometry,rt pcr,stem cells
Cost-effective aluminium die casting for automotive industry (FC21S)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-08-01
End date: 2018-10-31
Duration (months): 27.0
Total project cost (EUR): 1877978.75
EU funding (EUR): 1314585.13
Participants: 2
Project status: CLOSED

The automotive industry needs cost-effective solutions that enable it to reduce the weight of vehicles and in this way their emissions, so as to comply with increasingly stringent environmental regulations. The usual way of doing so is through the use of light car pieces which maintain structural performance concerning security, and in this way comply both with EU legislation and consumer needs. Aluminium die casted pieces perfectly address these needs: its light density enables to reduce weight by 40% compared to steel parts, and it presents outstanding mechanical performance. However, its die casting presents drawbacks such as high energy consumption and generation of large amounts of waste from release agents which are hardly avoidable. Our consortium, integrated by two Italian SMEs with expertise in the metal casting sector, aims to provide a solution to this issue: #FC21S is an innovative spraying process for aluminium die casting in which a pioneer concentrated mould release agent is nebulised through an ad-hoc micro-spraying head, rendering pieces with better mechanical properties and enhanced impact resistance. This system enables to reduce the amount of release agent from the current 12L to only 10 ml per piece, implying a cleaner and cheaper process. Moreover, it reduces bubble formation, what reduces the porosity in the aluminium casted piece, increasing its impact resistance. The overall objective of #FC21S is to achieve the industrialisation for the manufacturing of both #FC21S systems and structural aluminium car pieces, and in this way contribute to reducing the environmental impact of both the die-casting and the automotive industries. Moreover, through this project we aim to boost the competitiveness of both our companies, reaching overall revenues of about €21 million in the fifth year of commercialization, and increasing our personnel in about 15 people. With a Phase 2 investment of 1.99 million, this would imply a Return of Investment of 4.4.

Keywords: aluminium die casting,automotive industry,structural car pieces,ligther cars,less fuel consumption,less greenhouse and toxic gas emissions
RETHINK (RETHINK)

Framework: Horizon 2020 — Science with and for Society
Programme: Improving knowledge on science communication in order to improve the quality and effectiveness of interactions between scientists, general media and the public
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Belgium,Sweden,Serbia,Poland,Netherlands,United Kingdom,Portugal,Denmark
Call: Taking stock and re-examining the role of science communication (H2020-SwafS-2018-1, 2018)
Start date: 2019-01-01
End date: 2022-03-31
Duration (months): 39.0
Total project cost (EUR): 1198771.25
EU funding (EUR): 1198771.25
Participants: 10
Project status: CLOSED

Science communication is at a pivotal stage in its evolution due to the emergence of digital communication platforms that are not only presenting new opportunities but are also leading to new challenges. RETHINK will provide an unprecedented view of the new science communication landscape to reveal the barriers and inequalities that stand in the way of open and reflexive connections between science and society. It will also present the way forward, encouraging evidence-based transformations in science communication practice as well as guiding relevant policy to further open Research & Innovation (R&I) to society.To achieve this, RETHINK will provide a 360° view of the current science communication landscape. It will map current science communication activities across Europe, including those taking place in the currently uncharted digital sphere. It will seek input from R&I stakeholders who are currently disengaged with science communication. Outputs will be new ways of training those who engage in science communication, including those underserved by current training - such as bloggers and social media commentators. There will be online briefs aimed at changing current science communication practices to break down barriers preventing open R&I and reach underserved audiences across the EU. Strategies will be developed to improve individual and collective sensemaking by enhancing its openness and reflexivity. Guidance on policy will also be provided to create an environment that encourages open R&I. All of these outputs will be open access, as will the data generated during the research process to encourage a broad discussion and maximise uptake. RETHINK will bring about meaningful, long-term change in science communication to maximise the opportunities and overcome the challenges of digitalisation, allowing the sector to help society meet key challenges across the European community and beyond.

Keywords: responsible research and innovation,science journalism,science museums,science and society interface
Strategic Partnership of Emergency Medical Service Practitioners for Coordination of Innovation Procurement (iProcureSecurity)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Coordination and support actions
Countries involved: Italy,Ireland,Spain,Austria,Belgium,Greece,Türkiye
Call: Strategic pre-commercial procurements of innovative, advanced systems to support security (H2020-SU-SEC-2018, 2018)
Start date: 2019-05-01
End date: 2020-12-31
Duration (months): 20.0
Total project cost (EUR): 999975.0
EU funding (EUR): 999975.0
Participants: 10
Project status: CLOSED

Emergency Medical Services in Europe are characterised by a pluralistic landscape with diverse organisational setups, professional standards, coordination mechanisms and actors which result from different historical and institutional contexts in EU member states. However, diversity is united by the common aim, of providing timely care to victims of sudden and life-threatening injuries, emergencies or disasters within EU-member states (EUMS), in cross-border settings and international humanitarian missions. Fostering the response capacities and increasing the cooperation of the European Emergency Medical Services Systems (EMSS) is of decisive importance for strengthening the resilience of European societies in the light of multiple hazards: Climate change is increasing the frequency and severity of disasters, terrorism is becoming a very real scenario for mass causality events challenging both out-of-hospital as well as in-hospital emergency care, and health related hazards are calling for close cooperation of public safety and health authorities on an international level. Not only hazards but also the system’s diversity poses a challenge for preparedness planning and cooperation, which needs to involve the whole EMS system at regional and/or national level and integrate it into the whole health system and fully coordinate with the public safety system to be effective. The iProcureSecurity project seeks to identify the major challenges the system’s diversity poses to the ability to work together, stimulate R&I uptake with a view to increasing standardisation of operations across Europe, and deliver technical requirements for R&I activities to create a European system of Medical Emergency Teams that is more homogeneous and capable to work as singly unit. To achieve this aim, the project will engage in several exchange cycles with practitioners and other stakeholders in the innovation landscape as a preparation for major R&I activities as part of a PCP action.

Keywords: medical emergency services,community of practice,gaps assessment,innovation procurement,tender documents
Double Dynamics for design of new responsive polymer networks and gels (DoDyNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Italy,Germany,Belgium,Greece,Belgium,France,Netherlands,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-11-01
End date: 2021-10-31
Duration (months): 48.0
Total project cost (EUR): 3340690.2
EU funding (EUR): 3340690.2
Participants: 10
Project status: CLOSED

Polymeric gels and networks are ubiquitous in daily life (foodstuff, cosmetics) and high-added value applications (tissue engineering, adhesives, coating, drug release, portable batteries, additive manufacturing). They can be either permanent (covalently crosslinked) and resist flow, or physical (reversible) and easy to process while creeping at long times. The grand challenge is to efficiently combine and control within the same material, distinct features of these two classes of networks, such as large mechanical strength, deformability, swelling and self-healing, in order to create multiply responsive materials for new applications. The objective of DoDyNet is to develop a research roadmap that enhances our understanding of the synergistic effects arising by combining distinct dynamic modes within a polymeric network. These ‘Double Dynamics Networks’ (DDNs) are characterized by a multi-scale viscoelastic response that can be tuned via molar mass, fraction of component and dynamics of (transient or exchangeable) bonds. This will enable us to selectively tailor their macroscopic properties at molecular level. Based on this concept, the integrated research program involves (1) novel synthesis of different DDNs; (2) detailed analysis of structure; (3) rheology and dynamics; (4) modeling and simulations; and (5) mechanical properties relevant to applications. The ESRs will benefit from the close inter-connection among these complementary tasks with the goal to obtain criteria for designing and developing new industrial DDN systems and optimizing existing materials. DoDyNet is a highly interdisciplinary and inter-sectorial project, the groups involved are world-leaders in their fields, and the tasks strategically designed to ensure strong synergies. It offers young researchers an extraordinarily diverse training platform with a deep grasp of soft matter and unique exposure to industrial environment, needed to address emerging scientific and technological challenges.

Keywords: dynamics and structure of supramolecular polymers,rheology,soft matter and polymer physics,polymer relaxation,transient polymer network,fracture and adhesive properties,tube model