Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Delayed Transformational Fatigue in Central and Eastern Europe (FATIGUE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Estonia,Estonia,Hungary,Serbia,Hungary,Poland,Serbia,Poland,Czechia,Czechia,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 3508841.16
EU funding (EUR): 3508841.16
Participants: 18
Project status: CLOSED

The aim of FATIGUE is to develop theoretically and empirically robust explanations for the causes and consequences of rise of illiberalism and authoritarianism in post-communist Europe (and Europe, more generally) with reference to the concept of 'delayed transformational fatigue'. The project will seek to answer the following questions: i. Why do illiberal political discourses resonate with people in post-communist Europe? ii. With which types of people do illiberal discourses particularly resonate? iii. Under which social, economic and political circumstances are illiberal discourses most likely to gain traction? iv. How do illiberal political actors make their views of the world hegemonic? Which social, political and economic conditions of possibility enable such hegemonic worldviews to dominate political discourse? v. Which framing activities are employed by cultural-political entrepreneurs via specific media and educational institutions to make their views of the world hegemonic? vi. What are the remedies to the current illiberalism? What role does education play in making society aware of the dangers of playing with right-wing ideas. The research programme will be organised in five work packages, each centred on a research theme pertinent to one or more post-communist EU member-states, accession states or states in the EU’s Eastern Partnership. A sub-team, composed of three partners, will lead the work on each of the five dimensions of the delayed transformational fatigue: WP1: Illiberal democracy and right-wing politics WP2: Politics of memory and transitional justice WP3: Economic populism and inequality WP4: Cultures of reaction: xenophobia, anti-Semitism, anti-migrant WP5: Civil society and protest movements

Keywords: illiberalism,authoritarianism,central and eastern europe,transformational fatigue
Performance Optimisation and Productivity 2 (POP2)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: European Data Infrastructure
Action type: Research and Innovation actions
Partnership: HPC PPP (cPPP)
Countries involved: Germany,Germany,Germany,Spain,France,France,Czechia,United Kingdom
Call: HPC PPP - Centres of Excellence on HPC (H2020-INFRAEDI-2018-1, 2018)
Start date: 2018-12-01
End date: 2022-05-31
Duration (months): 42.0
Total project cost (EUR): 7605998.75
EU funding (EUR): 7605998.75
Participants: 8
Project status: CLOSED

The growing complexity of parallel computers is leading to a situation where code owners and users are not aware of the detailed issues affecting the performance of their applications. The result is often an inefficient use of the infrastructures. Even in the cases where the need to get further performance and efficiency is perceived, the code developers may not have insight enough on its detailed causes so as to properly address the problem. This may lead to blind attempts to restructure codes in a way that might not be the most productive ones. POP2 extends and expands the activities successfully carried out by the POP Centre of Excellence since October 2015. The effort in the POP project resulted in more than 120 assessment services provided to customers in academia, research and industry helping them to better understand the behaviour and improve the performance of their applications. The external view, advice, and help provided by POP have been extremely useful for many of these customers to significantly improve the performance of their codes by factors of 20% in some cases but up to 2x or even 10x in others. The POP experience was also extremely valuable to identify issues in methodologies and tools that if improved will reduce the assessment cycle time. The objective of POP2 is to continue and improve the POP project operating a Centre of Excellence in Computing Applications in the area of Performance Optimisation and Productivity with a special focus on very large scale towards exascale.POP2 will continue the service oriented activity, giving code developers, users and infrastructure operators an impartial external view that will help them improve their codes. We will still target the same categories of users and focus on identifying performance issues and proposing techniques that can help applications in the direction of exascale. Our objective is to perform 180 services over a three year period.

Keywords: performance tools and analysis,code optimization,parallel programming models,productivity
MOORING SYSTEM INTEGRITY MANAGEMENT THROUGH MONITORING, DIGITAL TWIN AND CONTROL TECHNOLOGIES FOR COST REDUCTION AND INCREASED EFFICIENCY (MooringSense)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Belgium,Norway,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Optimising manufacturing and system operation (H2020-LC-SC3-2019-RES-TwoStages, 2019)
Start date: 2019-11-01
End date: 2022-10-31
Duration (months): 36.0
Total project cost (EUR): 4197620.0
EU funding (EUR): 4197620.0
Participants: 11
Project status: SIGNED

The project MooringSense aims at reducing operational costs and increasing efficiency through the development of an efficient risk-based integrity management strategy for mooring systems based on an affordable and reliable on-line monitoring technology. The proposed solution will be enabled by the development of a low-cost smart sensor for FOWT motion monitoring, a Mooring System Digital Twin (DT) model, Structural Health Monitoring (SHM) techniques, as well as control strategies for mooring condition management tolerance at turbine and farm levels. The monitoring technology proposed will replace the existing unreliable and expensive monitoring systems based on load cells in the mooring lines by a combination of a robust motion sensor and numerical models. In addition, measurements will enable the development of more efficient operation and maintenance strategies, including optimized control. MooringSense’s consortium strength covers the full value chain, with a proven track record in the Offshore Wind and Oil and Gas Industries, and supported by experienced research institutions, the project will start from current partner’s technology to develop an innovative cost-efficient mooring integrity management enabled by Global Navigation Satellite System technology, coupled numerical modelling, control engineering and machine learning, with both increased efficiency of the overall resulting system as well as reduced operational expenditures, when compared with known incumbent alternatives.

Keywords: offshore wind energy,opex,mooring system digital twin,digital twin modelling,structural health monitoring,smart sensors,global navigation satellite system,shm algorithms
Automated Rail Cargo Consortium: Rail freight automation research activities to boost levels of quality, efficiency and cost effectiveness in all areas of rail freight operations (ARCC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Germany,Italy,Sweden,Sweden,Slovenia,Sweden,Sweden
Call: Start-up activities for Freight Automation (H2020-S2RJU-CFM-2015-01-1, 2015)
Start date: 2016-09-01
End date: 2021-04-30
Duration (months): 56.0
Total project cost (EUR): 1599999.99
EU funding (EUR): 1599999.99
Participants: 10
Project status: SIGNED

The overall aim of this specific Automated Rail Cargo Consortium (ARCC) proposal is to carry out an initial phase of rail freight automation research activities in order to boost levels of quality, efficiency and cost effectiveness in rail freight operations of the European railway sector. The three areas of research activities are: Transporting and delivering freight via automated trains, developing automated support processes at the nodes (e.g. terminals, yards and transhipment points) and advanced timetable planning. If automation and digitalisation processes are exploited in an appropriate way, rail freight transport can generate significant positive impacts for rail freight transport. For example, increased efficiency on the main railway lines and nodes, reducing lead time and energy costs. Additionally, improved services and customer quality so that the operational timetable is met reliably. Furthermore, optimised business processes and management of complex situations, such as a 15% reduction in time when rail assets sit idle within nodes. The Consortium is made up of Joint-Undertaking (JU) members of Shift2rail who are the main drivers in developing and transferring automation technologies and processes to the railway freight sector. The project will start with a Grade of Automation, level 2 (GoA2 level) demonstration and end with a GoA3/4 level crossborder demonstration. The start-up activities in this first batch of Shift2Rail projects will be followed up, in subsequent development phases to achieve higher levels of technical readiness, beyond the 36 month project period.

Keywords: rail freight automation,automated driving,process automation,real time data
European Industrial Doctorate in Innovative POLYmers for Lithium Battery TEchnologies (POLYTE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Belgium
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 743618.88
EU funding (EUR): 743618.88
Participants: 2
Project status: CLOSED

POLYTE-EID European Industrial Doctorate will offer excellent training opportunities to 3 Early Stage Researchers in the area of Polymers for Electrochemical Energy Storage. POLYTE-EID puts together the expertise in batteries for automotive of Toyota Motor Europe (TME) with the academic excellence in polymers of the University of the Basque Country (POLYMAT). The final objective is to train scientists who may face some of the upcoming European energy and transportation challenges. The project proposal is a well-balanced combination of fundamental material&polymer science with applied research in electrochemical energy storage technologies. The project will search the development of new polymeric materials to increase the performance and security of actual and future batteries.

Keywords: polymers for energy,polymer electrolytes,lithium batteries,electrochemical energy storage,electric vehicle,batteries for transportation
Uncover mechanisms of unconventional secretion of tau using functional CRISPR screens - From basic discoveries to neurodegenerative disease therapeutics (SeCRT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Most of secreted proteins transit through the endoplasmic reticulum (ER) and the Golgi apparatus. However, eukaryotic cells secrete cytosolic proteins, which do not enter the ER. Proteins that use this “unconventional secretory pathway” include factors with critical functions and deregulation of their transport is associated to a wide range of diseases. Yet, mechanisms of unconventional secretion remain largely uncharacterised. This represents a major gap in our understanding of fundamental mechanisms supporting protein trafficking and secretion. During my previous study, I developed a powerful platform for pooled genome-wide CRISPRi screening with the aim of identifying genes involved in protein transport in mammalian cells. In this proposal, I will use this approach to uncover mechanisms involved in the unconventional secretion of tau. During aging, abnormal accumulation of tau is a common pathological hallmark of neurodegenerative diseases (ND), including Alzheimer’s disease, for which there are no efficient therapeutic to prevent/slow down the pathogenesis. Compelling evidences suggest that tau aggregation occur via its transmission from neuron to neuron. Thus, tau secretion appears to be a pivotal event in promoting ND progression. For these reasons, to understand how tau is secreted is of critical importance. Objectives that will be addressed in this project will be to identify new factors required for tau secretion using a pooled genome-wide CRISPRi screen. Then, by combining biochemical and cellular approaches, as well as the last technologies for imaging, candidate genes will be functionally characterized. Finally, the most relevant factors will be evaluated as potential therapeutic target in zebrafish model of ND. This project will allow uncovering fundamental mechanisms to understand ND progression associated to the unconventional secretion of tau and could ultimately lead to the discovery of effective strategies to develop new therapies.

Keywords: unconventional protein secretion,protein and membrane trafficking,protein tau,pooled crispri screen,neurodegenerative disease
SuperScienceMe - REsearch is your RE-Generation (SUPERSCIENCEME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy,Italy,Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-05-01
End date: 2022-04-30
Duration (months): 12.0
Total project cost (EUR): 576468.5
EU funding (EUR): 298950.0
Participants: 7
Project status: CLOSED

"We are running out of time..." SuperScienceMe thought. "The earth cries out for help...we can't just stand there, we must do something and we must do it now...all together.." SuperScienceMe – REsearch is your RE-Generation fully embraces the European Green Deal, to reverse the course and to turn climate and environmental challenges into opportunities. In this historical moment, in which all certainties are falling apart dramatically, SuperScienceMe appeals to all generations and, like a modern Noah, units them around an ideal, calls them to build a symbolic ark, in order to convey the message that “Research can help regenerate the planet and save lives” Due to the recent events, the pandemic, the dramatic climate changes, the severe threats to democracy, our world is telling us something. In these difficult times, it is easy for people to feel disoriented and lose faith in science; the deniers, the conspiracy theorists, the insurrectionists, all of them are the result of this slow but continuous and inexorable drift. Once again, SuperScienceMe leverages the power of research and the enthusiasm of researchers, to enter the hearts and heads of people to slow down this wave until it reverses its path, before it's too late. To achieve this goal, building on the success of the past editions of the project, researchers from universities and institutions of two regions of southern Italy, Calabria and Basilicata, will open the doors of their laboratories; they will bring research to the non-specialized audience and will talk to people of any age, in order to show them the extraordinary normality of their superhero lives. Furthermore, in line with MSCA-NIGHT scope, the project, bringing researchers closer to the general public, will encourage the youth to embark on scientific careers also helping the planet. SuperScienceMe must open people's eyes and minds, to make them believe in science again, to defeat the darkness and restore the earth to its original color..the Green

Keywords: planet regeneration,green innovation,sustainability,climate change,civic and environmental education,science journey,enjoing research,dissemination of scientific culture,social inclusion
Estimating the effect of ride-hailing on public transportation (ride-hailing)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2022-06-30
Duration (months): 12.0
Total project cost (EUR): 93786.24
EU funding (EUR): 93786.24
Participants: 1
Project status: CLOSED

Uber, Lyft, and other ride-hailing companies have transformed the transportation marketplace in over eight-hundred cities around the world. These firms' entry into cities has been controversial. They have been credited with providing a reliable and affordable transportation option, serving neglected areas of cities, and providing meaningful employment. Against these benefits, however, they have been accused of being unsafe, creating congestion, destroying stable jobs, and flouting the law. Governments have struggled to decide how to regulate these companies, in part because of a poor understanding of the actual impacts ride-hailing is having. The proposed research program will increase our understanding of how ride-hailing is affecting cities. Specifically, the project will estimate how ride-hailing affects public transportation. Theoretically, this is unclear since while Uber is an alternative form of travel, it can also increase the reach and flexibility of public transportation. To measure the effect of UBer on transit, I will estimate how the introduction of new subway stops affects Uber ridership. This will shed light on whether Uber and public transportation are complements or substitutes. This project will use Uber's proprietary data. I have signed a Data USage Agreement with Uber allowing access to their data. The project will be hosted by the department of Spatial Economics at VU Amsterdam, which arguably has the world's leading research group of transportation economists.

Keywords: ride hailing,public transportation,uber,big data
An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Germany,Germany,Spain,Germany,Germany,Germany,Germany,Spain,Italy,Italy,Belgium,Belgium,Sweden,Switzerland,Sweden,Switzerland,Hungary,France,France,Netherlands,Netherlands,Netherlands,United States,Netherlands,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: New approaches to improve predictive human safety testing (H2020-PHC-2015-single-stage_RTD, 2015)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 30258439.92
EU funding (EUR): 27798299.0
Participants: 45
Project status: SIGNED

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.

Keywords: systems toxicology,molecular mechanisms,aops,cheminformatics,biokinetics,computational modelling,repeated dose toxicity,developmental and reproduction toxicity,risk assessment
Humanitarian Technology Interventions (HUMANITECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

There is growing global interest in the positive role of technology (such as mobile phones, sanitary toilets, or malaria nets) to alleviate problems associated with poverty and humanitarian crises. However, research on humanitarian technology interventions is overly technology-centric, focusing on issues of design, production, delivery, and efficiency. This research project will advance the study of humanitarian technology as an organisational phenomenon with the dual objective of advancing scholarship and informing intervention policy and practice. Specifically, the research project will explore three multi-level phenomena associated with humanitarian technology interventions: the role of rhetoric in establishing international technology standards, global organizing of interventions, and the experiences of user-beneficiaries. These will be explored through the following research methods and modes of analysis: case study design, dramatism, narrative interviews, and thematic analysis. Scholarly innovation and expertise will be realized by advancing and applying the research methodologies of dramatism and narrative interviews to study humanitarian technology interventions.

Keywords: humanitarian technology,humanitarian intervention,gender,multi level analysis,dramatism,narrative interviews,case study,fuel efficient stoves,sexual violence,sudan,darfur