Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Childhood Leukemia: Overcoming distance between South America and Europe Regions (CLOSER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Argentina,Uruguay,Austria,Italy,Czechia,United Kingdom,Chile
Call: Translational collaborative cancer research between Europe and the Community of Latin American and Caribbean States (CELAC) (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-03-31
Duration (months): 63.0
Total project cost (EUR): 3999601.25
EU funding (EUR): 3999601.25
Participants: 16
Project status: SIGNED

Cancer has become an important public health problem worldwide and inequalities in access to malignancies control result in differences in patients’ outcome. Despite the recent improvement of survival rates in childhood leukaemia, there is still a gap in survival between regions, even within well-organized international cooperative groups. Childhood leukaemia care should be addressed from a global point of view, considering not only scientific aspects, the amount of technological and human resources and the current health policies, but also economic, cultural, social, educational and environmental particularities across countries. The aim of CLOSER is to harmonize the levels of care and reduce inequalities in the outcome of childhood leukaemia patients in the Community of Latin American and Caribbean States (CELAC), and in European countries. To do that, we will create a framework of collaborative, multidisciplinary research between CELAC and European regions. From a scientific point of view, we seek to boost a constant exchange of the knowledge on the biology and the technological approaches needed for the diagnosis and follow-up of childhood leukaemia between regions, provide additional resources to perform research and develop new simplified methods to assure a fast translation from bench to bedside. From a social and educative point of view, we will empower patients and families in leukaemia care and encourage the participation of civil society by analysing their particular needs, by promoting advocacy tools, launching a platform to exchange initiatives and experiences in patients care, always acting with the highest respect for the individualities of each country and with the objective to contribute to a better quality of life. To make sure that we approach childhood leukaemia care from an integral perspective, we will include as partners researchers, physicians, patients and families, patients’ organizations, policymakers, small and medium-sized enterprises and civil society representatives. CLOSER will allow a more fluent collaboration worldwide to improve childhood leukaemia control and the quality of life of the patients and their caregivers.

Keywords: childhood leukaemia,translational research,clinical research,subtypes
Creation of a holistic methodology for REnovation Advice with focus on Lending solutions differentiated by target group. (C - R.E.A.L.)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Belgium,Belgium
Call: Integrated home renovation services (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 1514405.0
EU funding (EUR): 1514405.0
Participants: 3
Project status: SIGNED

The main objective of C-REAL is to establish a permanent, structural collaboration between a mortgage lender (Onesto) and a renovation adviser (Dubolimburg) to increase the degree of renovation and improve renovation quality in the province of Limburg. In addition to this and to achieve full customer satisfaction, an effective cooperation between the renovation adviser and contractors will be set up. Actively involving lenders to encourage home owners and home buyers to renovate provides significant added value. Lenders play a crucial role in purchasing and are frequently in contact with purchasers. Moreover, based on the existing customer relationship regarding the home, lenders can address owners directly. It is of great importance to lenders that homes that they finance are made optimally energy-efficient, as it is believed to reduce their risk. A supply of financing options, combined with a range of services to provide advice and guidance for the renovation, and timely and qualitative execution, provides all parties with significant added value, which paves the way for a clear, solid and scalable business model. In setting up these structural collaborations and offering integrated home renovation services, we will focus on the following 3 target groups, guiding them through the whole customer journey. We want to support : - home buyers in thoroughly renovating their home shortly after they have purchased it and preferably before moving into it; - owners who already have a current mortgage loan, urging them to make the home more energy efficient; - associations of co-owners (ACO’s) of apartment buildings. At the final stage C-REAL will document the methodologies developed and deployed on a small scale for each of these target groups and use it as a basis for recommendations to various potential stakeholders. In particular for Duwolim, the energyhouse in Limburg, who will integrate the project’s results into its current operation.

Keywords: holistic renovation advice,financing solutions,facilitating whole customer journey
Virtual tongue to predIct the oRganoleptic profile of mediterranean IngredienTs and their effect on hUman hOmeostasis by means of an integrated compUtational multiphysicS platform (VIRTUOUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Israel,Italy,Italy,Switzerland,Greece,Greece
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2019-12-01
End date: 2023-11-30
Duration (months): 48.0
Total project cost (EUR): 1108600.0
EU funding (EUR): 1108600.0
Participants: 11
Project status: SIGNED

VIRTUOUS is a virtual tongue made by an integrated computational framework able to screen food for natural ligands targeting taste receptors. The proposed intelligent algorithm, by integrating drug discovery techniques, machine learning classifiers, algorithms for big data, cloud computing, and experimental data will predict the organoleptic profile of a specific food based on its chemical composition. The outcomes of this research will shed light on the mechanisms driving the information transfer from the chemistry level, where food molecular constituents bind taste receptors, toward a cascade of molecular, supramolecular and cellular events emerging as an elaborated sensation which strongly contribute to the food organoleptic profile. The joint exchange programme involves 9 participants from 4 countries: Italy, Greece, Spain, Switzerland. Participants are both from academic (4 beneficiaries) and non-academic (5 beneficiaries) sectors. The balance between academy and industry and the interdisciplinary nature of the Consortium will grant a unique stimulating environment for researchers involved in the projects. Relevance of the program is identified at European and worldwide level, both for academia and industry. The idea of conceiving a taste predictor to be applied on European food products will boost and widen European food market at global level. The VIRTUOUS tongue may be also thought has an “food computer aided design tool” for EU food technology. For example, based on taste prediction the VIRTUOUS platform may be used in the future to predict the results of a specific grape graft. The Virtuous tongue may be also combined with other technologies to enhance precision agriculture. The VIRTUOUS research also links taste receptors’ activation to the activity of nuclear receptors following the paradigm of the Mediterranean Diet: “good and healthy”. Finally, the project is related to neuroscience, by considering molecular mechanisms of brain elaboration in taste.

Keywords: organoleptic profile,human homeostasis,mediterranian diet,molecular modelling,bioinformatics,molecular dynamics,taste,protein protein interactions
Anatomy in Ancient Greece and Rome: An Interactive Visual and Textual Atlas (ATLOMY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1498205.0
EU funding (EUR): 1498205.0
Participants: 1
Project status: SIGNED

ATLOMY sets out to break through the textual boundary of ancient anatomical writings and produce a groundbreaking integrative atlas of Greco-Roman anatomical ideas, terminology, and research. Its historical scope will stretch from the Classical period to the High-Roman Empire – from our earliest extant Greek medical works to the pinnacle of Greco-Roman medical and anatomical research. It will focus on the authors whose works and ideas had the most long-lasting formative role in the history of anatomy and biology: key medical writers of the fifth to the third centuries BCE (e.g. Hippocratic authors and the Alexandrian anatomists); Aristotle (fourth century BCE); and Galen of Pergamum (second century CE). Based on rigorous philological and historical analyses of the sources, ATLOMY’s team of classicists, historians, modern anatomists, digital artist, and software developer, will create a long-desired lexicon of ancient anatomical terms, re-enact ancient anatomical dissections, and develop a high-end, digital visual atlas presenting three-dimensional reconstructions of the body as perceived by the different authors. Based on the novel results of these analytical, empirical, and digital clusters of research, we shall compose in-depth interpretive studies of anatomical theories and research in ancient Greece and Rome. This integrative visual and textual map and analysis will substantially advance our understanding of ancient ideas of the body and of empirical methods of scientific research in ancient times. Moreover, it will enable the growing audience of Greco-Roman medical and philosophical writings to engage with these sources in a deeper and more informed manner, thus enhancing studies in related fields. More broadly, ATLOMY will offer a tight-knit interdisciplinary heuristic model for the study of the history of science, one which offers means for bridging the disciplinary gap between historians and classicists and the natural scientists whose works we study.

Keywords: ancient medicine,ancient philosophy,ancient science,body,digital humanities,dissection,empirical observation,history of anatomy,re enactment,scientific method,theory practice,veterinary
ADVANCED LASER DIAGNOSTICS FOR DISCHARGE PLASMA (LAPLAS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1959845.0
EU funding (EUR): 1959845.0
Participants: 1
Project status: SIGNED

The aim of this proposal is to (1) develop state-of-the-art laser diagnostics for investigating plasma phenomena and (2) demonstrate and apply these methods in relevant conditions for plasma-discharge applications. Plasmas are widely used in applications and research for e.g. surface and gas treatment, ignition systems and material processing. Development of application designs and approaches for modelling these complex processes have led to better optimized systems. Plasma-discharge formation is randomized and transient and these plasma-induced processes occur in volatile and harsh environments. Conventional methods for investigating plasma phenomena mainly rely on electric probe techniques, ex-situ mass spectroscopy or passive light emission analysis. Intermediate phenomena are rarely studied in-situ and little is known about intermediate states and governing processes, making plasma-discharge applications hard to assess and analyse. Development of laser diagnostic techniques and extensive hardware development has led to rapid advances in a various other research fields the last decades. These previous efforts provide a solid foundation for development of advanced laser-based plasma diagnostics and ground-breaking investigations of stochastic discharge plasma phenomena. This proposal is arranged in a number of work packages where the PI has unique expertise for developing state-of-the-art laser diagnostics techniqes. An example is ultra-high speed videography where the PI recently invented the world’s fastest video camera. This method is uniquely tailored for plasma investigations since it can be used in spectroscopic investigations of single events. The outcome of this project is to (I) provide experimentalist with novel diagnostic tools for studies of plasma phenomena and (II), generate experimental data that will increase understanding of plasma-induced phenomena for scientists and enginee.

Keywords: laser based plasma diagnostic techniques
Carbon Captured Fuel and Energy Carriers for an Intensified Steel Off-Gases based Electricity Generation in a Smarter Industrial Ecosystem (C2FUEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Belgium,Finland,France,France,France,France,Netherlands,Denmark
Call: Conversion of captured CO2 (H2020-LC-SC3-2018-NZE-CC, 2018)
Start date: 2019-06-01
End date: 2023-11-30
Duration (months): 54.0
Total project cost (EUR): 4130291.25
EU funding (EUR): 3999840.0
Participants: 14
Project status: SUSPENDED

C2FUEL project aims to develop energy-efficient, economically and environmentally viable CO2 conversion technologies for the displacement of fossils fuels emission through a concept of industrial symbiosis between carbon intensive industries, power production, and local economy. This concept will be demonstrated at Dunkirk between DK6 combined cycle power plant, Arcelor Mittal steel factory and one of the major European harbor, a solid showcase for future replication. The CO2 present in the blast furnace gas will be selectively removed and combined with green hydrogen generated by electrolysis fed with renewable electricity to produce two promising energy carriers. It will allow to simultaneously reuse CO2 emission from the steel-making factory, electricity surplus in the Dunkirk area and to improve the operational and environmental performance of the DK6 combined cycle. C2FUEL unique circular approach could contribute to mitigate up to 2,4 Mt CO2 per year. Key technical and economic challenges to be tackled in the project are high temperature electrolysis, innovative production routes of DME and FA from renewable H2 and captured CO2. The developed processes will be integrated, demonstrated and validated in an industrial relevant environment and the produced fuel will be tested in real end-user systems. Technical-economic-environmental feasibility and societal acceptance will be carried out to ensure the replication potential. C2FUEL key projected targets are an annual production of 2,4 Mt of formic acid, 100 kt of green hydrogen for seasonal storage using 3,6TWh of renewable electricity and 1,2 Mt of DME with 320 kt of green hydrogen using 11TWh of renewable electricity. C2FUEL partnership gathers the whole value chain necessary for production and use of CO2 conversion to carbon-captured energy carriers : carbon captured supply, renewable hydrogen and fuel development, integration to power plant and operation, as well as end-users and international promoters.

Keywords: co2 conversion,off gases based power plant,circular economy,industrial ecology,carbon captured energy carrier,renewable h2,formic acid,dimethylether,solid oxide electrolysis,membrane reactor
Training and research in Listeria monocytogenes Adaptation through Proteomic and Transcriptome deep Sequencing Analysis (List_MAPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Ireland,Ireland,Germany,Germany,France,France,France,France,Netherlands,Denmark,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 2841979.5
EU funding (EUR): 2841979.5
Participants: 11
Project status: CLOSED

List_MAPS is a network dedicated to the training of innovative young researchers in the field of Microbiology and Systems Biology. It focuses on Listeria monocytogenes, an ubiquitous pathogen that is in the EU the leading cause of mortality and food recalls due to foodborne pathogens, costing the EU millions of euro per annum in medical care and associated costs in the food sector. ESRs will develop scientific expertise through PhD training, mobility of researchers, summer schools, workshops and transfer-of-knowledge in the areas of Transcriptomics, Proteomics, Sequencing and Systems Biology. Working in this dynamic state-of-the-art field will provide for training of ESRs to the highest level, with co-operation and movement between academia and industry that will enhance ESR training. The overall objective of the research programme is to tackle food safety through the combination of high throughput Epigenetics, Deep sequencing of transcripts, Proteomics, Bioinformatics, Mathematics and Microbiology to decipher the transcriptional regulatory circuitry that drives adaptation and virulence of L. monocytogenes from farm to fork. This information will be exploited to understand how environmental conditions and food composition can influence GI tract adaptation/virulence and to develop an innovative transcriptome-based tool to assess in silico the virulence of large collections of isolates. This developed tool aims at replacing the currently used burdensome animal models. In addition to excellent scientific competences, competitive research requires a range of transferable skills to secure funding, optimise management of working teams and exploit research results. List_MAPS proposes an innovative approach to the training of ESRs in these transferable skills, combining socio-constructivist learning theory with Open Educational Resources to design and provide blended learning courses. This will secure world-class training for creative, entrepreneurial and innovative ESRs.

Keywords: listeria monocytogenes,adaptation,transmission,soil,plant,food processing,food matrix,transcriptomic,proteomic,regulatory circuitry modelling,online resources blended learning
Light-Addressable 2D Covalent-Organic Framework Semiconductors (LA2DCOFS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

LA2DCOFS will offer an extremely talented and promising young researcher with a PhD in chemistry and an extraordinary track record a world-class training throuDiscovery and development of two-dimensional (2D) semiconductors marked a milestone in modern condensed matter physics and material science. These structures exhibit unique set of properties and excel in almost every aspect of the device performance over their three-dimensional counterparts. Among these materials, recently developed semiconducting 2D covalent-organic frameworks (2D COFs) received a significant attention owning to their exceptional environmental stability, tunability, processability and modular synthesis. However, to date, these structures remain passive, which limits their potential applications. To address this challenge, this proposal describes our plans to develop light-responsive 2D COF-based semiconductors. More specifically, we will integrate light-responsive molecules – dithienyl ethenes (DTEs) – in the backbone of the crystalline imine-linked framework which will allow us to gain a remote control over their performance in electronic devices with light stimulus. We will fabricate a library of networks, consisting of various likers and DTEs and validate their performance and light-responsive function in field-effect transistor devices. Furthermore, the fabricated structures will be modified by post-synthetic reactions on the network linkages to further improve their charge transport properties and thus performance in proof of a concept device. Finally, we will integrate several DTEs with distinct electronic properties into one framework, thus creating a multivariate semiconductive 2D COFs, which will allow us to gain a simultaneous photocontrol over several parameters of the electronic devices. Overall our efforts, if successful, will result in fabrication of unprecedented semiconducting materials and will pave the way for the development of future technologies based on these materials.

Keywords: 2d cofs,molecular photoswitches,2d semiconductors,responsive materials