Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MARINE environmental in situ Assessment and monitoring tool BOX (MARIABOX)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Cyprus,Spain,Ireland,Italy,Italy,Norway,Spain,Spain,Ireland,United Kingdom,Italy
Call:  (FP7-OCEAN-2013, 2013)
Start date: 2014-02-01
End date: 2018-01-31
Duration (months): 48.0
Total project cost (EUR): 7137921.51
EU funding (EUR): 5175858.0
Participants: 13
Project status: CLOSED

MariaBox will develop a wireless marine environment analysis device for monitoring chemical and biological pollutants while installed into a buoy, a maritime means of transport or a mooring. The device, based on novel biosensors, will be of high-sensitivity, portable and capable of repeating measurements over a long time, allowing permanent deployment at sea. The word “MARIA” is the plural of the Latin “mar” (sea) and expresses the wide applicability that this system offers in multiple locations where low-cost and real-time in situ analytical monitoring devices are required. The approach includes: a) a sensing and analysis box, b) a modular communication system, c) a flexible power system, d) a software platform, and e) a cell phone application. The box will transmit the collected data in real time through different channels according to local needs and geographical location: radio, GSM/GPRS/3G, WiFi, WiMAX or satellite link. The unit will be designed to be remotely controlled and will implement the OTA programming and OTA configuration features which will allow the user to update the firmware of the MariaBox unit and modify various configuration parameters wirelessly. Remote updates are a key factor in deployment scalability since it offers the only possibility of easily updating or reprogramming the devices after the initial deployment. Therefore, the maintenance costs are significantly reduced. Biosensors will be developed for 5 man-made chemicals and for 4 categories of microalgae toxins relevant to shell fish and fish farming. The novel biosensors will contribute to new standards for environmental analysis. The analytes selected for the biosensors are in line with 1) the Article 16 of the Water Framework Directive (2000/60/EC), 2) the Decision 2455/2001/EC and 3) The Commission Directive 2009/90/EC. The system developed will be demonstrated and validated in four different scenarios in selected locations in Norway, Spain, Cyprus and Ireland.

Keywords: water quality monitoring,biosensors,in-situ ocean observing systems,autonomous multifunctional sensors and system
Rigidity and classification of von Neumann algebras (RIGIDITY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Mathematics
Countries involved: Belgium
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-07-01
End date: 2019-06-30
Duration (months): 60.0
Total project cost (EUR): 1446660.0
EU funding (EUR): 1446660.0
Participants: 1
Project status: CLOSED

Sorin Popa's deformation/rigidity theory has lead to an enormous progress in our understanding of von Neumann algebras coming from discrete groups and their actions on probability spaces. In a five year long collaboration with Sorin Popa, we solved many long-standing open problems in this area, including superrigidity theorems for group measure space II_1 factors, results on the possible fundamental groups of II_1 factors, and uniqueness theorems for Cartan subalgebras. In the first part of the project, we want to establish new unique Cartan decomposition theorems for II_1 factors coming from hitherto intractable groups. Using methods coming from Lie groups, ergodic theory and geometric group theory, we want to reach such results for lattices in higher rank simple Lie groups, and for countable groups with nonvanishing L^2-Betti numbers. An important intermediate step will be the unique Cartan decomposition of Bernoulli crossed products. Secondly we want to prove classification theorems for type III factors that are equally strong as the existing results for the type II_1 case. This includes a complete classification of the noncommutative Bernoulli shifts of the free groups and will require an intricate combination of Tomita/Takesaki and deformation/rigidity theory. The methods developed so far bring within reach an attack on two of the most important open problems in operator algebras and functional analysis: the free group factor problem and Connes's rigidity conjecture. The exact progress on these problems is of course unforeseeable, but it is sure that the research on these problems will lead to an even deeper interaction between diverse areas of mathematics as operator algebras, group theory, functional analysis, ergodic theory, and descriptive set theory. Intermediate goals are the classification of natural classes of group von Neumann algebras, including those coming from Baumslag-Solitar groups, wreath product groups, and other families of discrete groups.

Keywords: von neumann algebra,ii_1 factor,ergodic theory of group actions,deformation/rigidity theory
The formation and evolution of massive black holes (BLACK)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Universe Sciences
Countries involved: France
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-06-01
End date: 2019-05-31
Duration (months): 60.0
Total project cost (EUR): 1668385.0
EU funding (EUR): 1668385.0
Participants: 1
Project status: CLOSED

Massive black holes (MBHs) weighing million solar masses and above inhabit the centers of today's galaxies, weighing about a thousandth of the host bulge mass. MBHs also powered quasars known to exist just a few hundred million years after the Big Bang. Owing to observational breakthroughs and remarkable advancements in theoretical models, we do now that MBHs are out there and evolved with their hosts, but we do not know how they got there nor how, and when, the connection between MBHs and hosts was established. To have a full view of MBH formation and growth we have to look at the global process where galaxies form, as determined by the large-scale structure, on Mpc scales. On the other hand, the region where MBHs dominate the dynamics of gas and stars, and accretion occurs, is merely pc-scale. To study the formation of MBHs and their fuelling we must bridge from Mpc to pc scale in order to follow how galaxies influence MBHs and how in turn MBHs influence galaxies. BLACK aims to connect the cosmic context to the nuclear region where MBHs reside, and to study MBH formation, feeding and feedback on their hosts through a multi-scale approach following the thread of MBHs from cosmological, to galactic, to nuclear scales. Analytical work guides and tests numerical simulations, allowing us to probe a wide dynamical range. Our theoretical work will be crucial for planning and interpreting current and future observations. Today and in the near future facilities at wavelengths spanning from radio to X-ray will widen and deepen our view of the Universe, making this an ideal time for this line of research.

Keywords: black holes,active galactic nuclei
The Application of Modern Proteomic and Metabolomic Methodologies in the Assessment of High Added-Value Traditional Meat Products (HIGHVALFOOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-01-01
End date: 2016-06-30
Duration (months): 30.0
Total project cost (EUR): 62500.0
EU funding (EUR): 62500.0
Participants: 1
Project status: CLOSED

Food quality and safety are central to any society, having important economic, social and environmental implications. International comparisons have shown that the European Union is the world’s largest producer of food and drink products. It is not surprising therefore that the Agro-food sector has major importance/influence on the economy of Europe. The proposed research programme will give the researcher the opportunity to perform multidisciplinary activities that impact directly on food quality and safety. Experimentally the project will utilise recent advances in mass spectrometry and data analysis to develop modern proteomic and metabolomic approaches suitable for use in the assessment of traditional foodstuffs. To achieve these goals the following objectives will be addressed: (i) Development of a label-free quantitative proteomic method and metabolomic approaches to identify and quantify novel biologically active peptides with the objective to increase the health value of traditional meat products, (ii) study of the peptides generated at different time intervals during the processing of traditional Spanish dry-cured ham to correlate with the time of processing and use as safety and quality markers of the final product, and (iii) analysis the ‘omic’ datasets using independent statistical analysis (e.g. Principal Component Analysis (PCA) and ANOVA) and advanced proteomic-related software such as Mascot Distiller. The development of this project will enable the researcher to improve state of the art expertise in generic technologies, which are of strategic importance throughout Europe. The approaches developed will impact directly on the assessment of traditional foodstuffs advancing the present state of the art in the field. There is perfect synergy between the researcher’s background and host reintegration group expertise, providing the foundations for a productive project, delivering scientific excellence with translational impact.

Keywords: food quality and safety,proteomics,metabolomics,data analysis
Savings and Risks Over the Lifecycle: Theory and Evidence (SAVINGS AND RISKS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Individuals, Institutions and Markets
Countries involved: United Kingdom
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 1216477.0
EU funding (EUR): 1216477.0
Participants: 1
Project status: CLOSED

People save for many reasons, such as to finance their retirement, to leave bequests to others, to start and develop a business, and to self-insure against risks. When young, these risks include wage risk, unemployment risk, entrepreneurial risk, and divorce risk. When old, one risks living to a very old age and running out of assets, being hit by expensive medical needs, and losing one’s spouse. An important factor affecting people’s risk exposure, and hence saving behaviour, is the public insurance provided by governments. Risks and insurance influence key economic choices and affect people’s welfare, macroeconomic aggregates, and inequality. The proposed research will develop and test models of individual and household saving to a) provide novel evidence on the determinants of saving at different ages; b) better quantify the interaction of saving with the insurance provided by the government and by one’s family; c) study how individual-level decisions affect macroeconomic conditions and the distribution of wealth; d) evaluate the effects of policy proposals and different institutions using quantitative model economies, calibrated to both the U.S. and European countries. The proposed applications include studying (i) the effects of means-tested public health insurance and its reforms on single retirees. (ii) A structural model of couples’ savings and risks in old age. (iii) Couples’ savings and labour supply during their whole life cycle, including the working stage. (iv) The effects of credit shocks on the saving and hiring of small-business owners and the resulting aggregates. (v) Differences in wealth accumulation between the healthy and the unhealthy. By better modeling and quantifying saving motives, risks, and publicly provided insurance, we can propose more efficient reforms. By applying our analysis to both the US and to European economies we can reach a better understanding of the effects of different institutions across countries.

Keywords: savings,medical expenses,risk,bequest motives,family insurance,policy reforms,labor supply,inequality.
Regulation of inflammatory response by extracellular ATP and P2X7 receptor signalling: through and beyond the inflammasome. (DANGER ATP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Immunity and Infection
Countries involved: Spain
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-09-01
End date: 2020-08-31
Duration (months): 72.0
Total project cost (EUR): 1794948.0
EU funding (EUR): 1794948.0
Participants: 1
Project status: CLOSED

Inflammatory diseases affect over 80 million people worldwide and accompany many diseases of industrialized countries, being the majority of them infection-free conditions. There are few efficient anti-inflammatory drugs to treat chronic inflammation and thus, there is an urgent need to validate novel targets. We now know that innate immunity is the main coordinator and driver of inflammation. Recently, we and others have shown that the activation of purinergic P2X7 receptors (P2X7R) in immune cells is a novel and increasingly validated pathway to initiate inflammation through the activation of the NLRP3 inflammasome and the release of IL-1β and IL-18 cytokines. However, how NLRP3 sense P2X7R activation is not fully understood. Furthermore, extracellular ATP, the physiological P2X7R agonist, is a crucial danger signal released by injured cells, and one of the most important mediators of infection-free inflammation. We have also identified novel signalling roles for P2X7R independent on the NLRP3 inflammasome, including the release of proteases or inflammatory lipids. Therefore, P2X7R has generated increasing interest as a therapeutic target in inflammatory diseases, being drug like P2X7R antagonist in clinical trials to treat inflammatory diseases. However, it is often questioned the functionality of P2X7R in vivo, where it is thought that extracellular ATP levels are below the threshold to activate P2X7R. The overall significance of this proposal relays to elucidate how extracellular ATP controls host-defence in vivo, ultimately depicting P2X7R signalling through and beyond inflammasome activation. We foresee that our results will generate a leading innovative knowledge about in vivo extracellular ATP signalling during the host response to infection and sterile danger.

Keywords: macrophage,danger signals,extracellular atp,p2x7 receptors,nlrp3 inflammasome,caspase-1,interleukin-1b,cd14,redox signaling,in vivo bioluminiscence,bioluminescence resonance energy transfer
Multidimensional Ultrafast Time-Interferometric Spectroscopy of Coherent Phenomena in all Environments (MULTISCOPE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical Sciences
Countries involved: Germany
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-04-01
End date: 2019-03-31
Duration (months): 60.0
Total project cost (EUR): 2669124.0
EU funding (EUR): 2669124.0
Participants: 1
Project status: CLOSED

We propose to develop and apply novel methods of nonlinear spectroscopy to investigate the significance and consequences of coherent effects for a variety of photophysical and photochemical molecular processes. We will use coherent two-dimensional (2D) spectroscopy as an ideal tool to study electronic coherences. Quantum mechanics as described by the Schrödinger equation is fully coherent: The phase of a wavefunction evolves deterministically in the time-dependent case. However, observations are restricted to reduced “systems” coupled to an “environment.” The resulting transition from coherent to incoherent behavior on an ultrafast timescale has many yet unexplored consequences, e.g. for transport in photosynthesis, photovoltaics or other molecular “nanomaterials.” In contrast to conventional 2D spectroscopy, we will not measure the coherently emitted field within a four-wave mixing process but rather implement a range of incoherent observables (ion mass spectra, fluorescence, and photoelectrons). Yet we can still extract all the desired information using “phase cycling” with collinear pulse sequences from a femtosecond pulse shaper. This opens up a new range of interdisciplinary experiments and will allow for the first time a direct nonlinear-spectroscopic comparison of molecular systems in all states of matter. Specifically, we will realize 2D spectroscopy in molecular beams, liquids, low-temperature solids, and on surfaces including heterogeneous and nanostructured samples. Tuning the external couplings will help elucidating the role of the environment in electronic (de)coherence phenomena. Furthermore, we will combine 2D spectroscopy with subdiffraction spatial resolution using photoemission electron microscopy (PEEM). This enables us to map transport in molecular aggregates and other heterogeneous nanosystems in time and space on a nanometer length scale. Thus we access the intersection between the domains of electronics and nanophotonics.

Keywords: coherent 2d spectroscopy,ultrafast spectroscopy
New Outlook on seismic faults: From EARthquake nucleation to arrest (NOFEAR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Earth System Science
Countries involved: United Kingdom,Italy,United Kingdom
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-07-01
End date: 2019-12-31
Duration (months): 66.0
Total project cost (EUR): 1963800.0
EU funding (EUR): 1963800.0
Participants: 4
Project status: CLOSED

With an average toll of 80.000 deaths per year over the last decade, earthquakes remain one of the most dreadful geohazards. The advancement of earthquake risk assessment and forecasting methods (probability estimates that a mainshock may occur in terms of hypocentre location, magnitude and time) calls for a sound physical basis. The nucleation, propagation and arrest of an earthquake rupture results from the interplay of stress perturbations, micro- to macro-scale friction- and rupture-related processes and fault zone geometrical complexity. Most of the information about these parameters is out of reach of seismic waves and geophysical analysis. Here we aim at enhancing our knowledge of earthquake physics (from nucleation to arrest) by means of a multidisciplinary approach that includes: 1) experiments to investigate earthquake nucleation by reproducing crustal (pressure, temperature, presence of fluids, stress perturbations, etc.) deformation conditions with the most powerful earthquake simulator installed worldwide (SHIVA); 2) experiments to investigate rupture propagation on simulated faults using natural rocks and small-scale analogue models; 3) field studies of exhumed seismogenic sources to quantify the geometrical complexity of natural fault zones; 4) advanced numerical simulation techniques that will integrate the above information and allow up-scaling to natural faults. The numerical models will produce physically-based earthquake simulations that will be compared with high-resolution seismic data. By reproducing crustal deformation conditions (stress, temperature, fluid pressures, etc.) in the laboratory and by monitoring acoustic emissions, gases, electromagnetic waves, etc., produced by the rock samples during deformation, a by-product of our research will be the systematic investigation of precursory phenomena (seismic, chemical, and electromagnetic) associated to earthquake nucleation processes.

Keywords: earthquakes,faults,friction,experiments,modelling,tribology,rock deformation,landslides,precursors
Surface-Based Molecular Imprinting for Glycoprotein Recognition (GLYCOSURF)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Products and Processes Engineering
Countries involved: United Kingdom
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-12-01
End date: 2020-11-30
Duration (months): 72.0
Total project cost (EUR): 1894046.0
EU funding (EUR): 1894046.0
Participants: 1
Project status: CLOSED

There is now overwhelming evidence that glycosylation changes during the development and progression of various malignancies. Altered glycosylation has been implicated in cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases. Currently, antibodies are playing a central role in enabling the detection of glycoprotein biomarkers using a variety of immunodiagnostic tests. Nonetheless, antibodies do have their own set of drawbacks that limit the commercialization of antibody sensing technology. They suffer from poor stability, need special handling and require a complicated, costly production procedure. More importantly, they lack specificity because they bind only to a small site on the biomarker and are not able to discriminate, for instance, among different glycosylated proteins. The current antibody diagnostic technology has well recognized limitations regarding their accuracy and timeliness of diagnose of disease. This project will focus on research into the means of developing a generic, robust, reliable and cost-effective alternative to monoclonal antibody technology. The project aims to exploit concepts and tools from nanochemistry, supramolecular chemistry and molecular imprinting to provide highly innovative synthetic recognition platforms with high sensitivity and specificity for glycoproteins. Such novel type of platforms will make a profound and significant impact in the broad fields of biosensors and protein separation devices with applications in many areas such as biomedical diagnostics, pharmaceutical industry, defense and environmental monitoring. The proposed technology may open an untraveled path in the successful diagnosis, prognosis and monitoring of therapeutic treatment for major diseases such as cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases.

Keywords: nanoengineering of surface materials,surface chemistry,glycoproteins,saccharide recognition,molecular imprinting,self-assembled monolayers,surface hydrogels,surface plasmon resonance.