Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Community-Based Policing and Post-Conflict Police Reform (ICT4COP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Ireland,Norway,Poland,Norway,United Kingdom,United Kingdom,United Kingdom
Call: Ethical/Societal Dimension Topic 2: Enhancing cooperation between law enforcement agencies and citizens - Community policing (H2020-FCT-2014, 2014)
Start date: 2015-06-01
End date: 2020-11-30
Duration (months): 66.0
Total project cost (EUR): 4999999.0
EU funding (EUR): 4999998.0
Participants: 13
Project status: CLOSED

The challenges of international police reform assistance are formidable. Conventional top-down institutional reform has proven neither effective nor sustainable. Community-based policing (COP) holds promise, however evaluations have pointed to a lack of in-depth understanding of police-community relations in police reform assistance. This project will conduct integrated social and technical research on COP in post-conflict countries in S.E. Europe, Asia, Africa and Central America. New knowledge, reflection on lessons learnt and “best practices” will support both national police and EU/International police reform assistance. The project will lead to a better understanding of police-community relations, and innovation in information and communication technology (ICT) for enhancing these relations in post-conflict countries undergoing serious security reform. Linking social and technological research, the project will study social, cultural, human security, legal and ethical dimensions of COP to understand how citizens and police can develop sustainable relations with the use of ICTs. We will explore how technological innovation can support COP in crime reporting and prevention. The project will explore ICT solutions to facilitate, strengthen and accelerate positive COP efforts and police-citizen interactions where trust levels are weak. Solutions will depend on the context and identified needs of end-users: communities, local police, national and international police (EU/UN), and policymakers, and may include citizen reporting, information monitoring, mobile value transfer, or improved organizational systems. The project includes a Policing Experts Network whose role is to support research planning, and dissemination and exploitation of findings, grounding the research in police practice. This will ensure findings are communicated by engaged police practitioners, and directly applied in COP education and training curricula in Europe and case countries.

Keywords: development,police reform,post conflict,youth,gender
Kleptoplasty: The sea slug that got away with stolen chloroplasts (KleptoSlug)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 2255461.0
EU funding (EUR): 2255461.0
Participants: 1
Project status: SIGNED

Rationale: Photosynthesis is almost exclusively restricted to algae and plants, with the exception of some protozoans, flatworms and marine slugs that acquire chloroplasts from algae. In metazoans, the capacity to incorporate functional chloroplasts (kleptoplasty) for long periods of time has only been described in sacoglossan sea slugs. Some species retain kleptoplasts photosynthetically active for several months that persist without access to algal gene products and despite the release of potentially dangerous metabolites, including reactive oxygen species (ROS). While kleptoplasty is intriguing from an evolutionary perspective, there are many unresolved questions on how the algal organelle is incorporated into the metabolism of an animal cell and what the host-associated benefits are. Aim: This proposal will unravel the cellular mechanisms supporting the sequestration and maintenance of functional chloroplasts inside metazoan cells and determine the host benefits of harboring kleptoplasts. Approach: The expertise in keeping a variety of species will form the backbone of my state-of-the-art experimental strategy, comparing a wide range of different animal-alga associations in their response to chloroplast incorporation and variable ability to functionally maintain them. Lipidomic and transcriptomic analyses will unravel in a comparative approach the species-specific maintenance strategies underlying kleptoplasty. In addition, the impact of cytotoxic compounds produced by active kleptoplasts and in particular ROS production and scavenging will be explore. Finally, I will determine the fate of inorganic carbon and nitrogen to explore the contribution of photosynthesis-derived compounds to the physiology of the host. Impact: This analysis will resolve some of the long-standing questions regarding the maintenance of photosynthetically active chloroplasts in animal cells and produce crucial insights about long-term kleptoplasty in sacoglossan sea slugs.

Keywords: kleptoplasty,lipidomics,nanosims,photosynthesis,symbiosis,reactive oxygen species,sacoglossa,stable isotopes
AUGMENTED COOPERATION IN EDUCATION AND TRAINING IN NUCLEAR AND RADIOCHEMISTRY (A-CINCH)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Action type: Coordination and support actions
Countries involved: Germany,Germany,Italy,Cyprus,Norway,Finland,Sweden,Russian Federation,Belgium,Slovenia,France,Czechia,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Advancing nuclear education (NFRP-2019-2020, 2019)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 3120856.0
EU funding (EUR): 2490000.0
Participants: 17
Project status: SIGNED

Expertise in nuclear and radiochemistry (NRC) is of strategic relevance in the nuclear energy sector and in many vital applications. The need for radiochemistry expertise will even increase as the focus shifts from safe nuclear power plant operation to decontamination and decommissioning, waste management and environmental monitoring. The non-energy fields of NRC applications are even much broader ranging from life sciences – radiopharmaceuticals, radiological diagnostics and therapy – through dating in geology and archaeology, (nuclear) forensics and safeguards operations, to radiation protection and radioecology. The A-CINCH project primarily addresses the loss of the young generation's interest for nuclear knowledge by focusing on secondary / high school students and teachers and involving them by the “Learn through Play” concept. This will be achieved by bringing advanced educational techniques such as state-of the art 3D virtual reality NRC laboratory, Massive Open Online Courses, RoboLab distance operated robotic experiments, Interactive Screen Experiments, NucWik database of teaching materials, or Flipped Classroom, into the NRC education. All the new and existing tools wrapped-up around the A-CINCH HUB – a user-friendly and easy-to-navigate single point of access – will contribute increasing the number of students and trainees in the field of nuclear and radiochemistry. Nuclear awareness will be further increased by the High School Teaching Package, Summer Schools for high school students, Teach the Teacher package and many others. Additionally, successful educational and training tools from previous projects will be continued and further developed. Networking is an important part of the project, facilitated by having ENEN as one of the partners and by having structural links with other Euratom projects, the EuChemS, the NRC-Network as well as by additional links with other end users and stakeholders including the high schools.

Keywords: nuclear,teaching materials,nuclear chemistry,radiochemistry,flipped classroom,distance learning,gamification,virtual reality,mooc,virtual laboratory,nuclear awareness
Urban Centres and Landscapes in Transition. The Mediterranean FarWest in Late Antiquity (MED-FARWEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

MED-FARWEST is a strongly innovative project that, focussing on the territory located in the far west of the Roman Empire, namely the Iberian Peninsula, will analyse two of the most interesting yet poorly understood phenomena of the crucial period of Late Antiquity (AD 300-700): 1. the complete abandonment of some cities and 2. the dismantling of the Roman rural world. Both phenomena have long seen consideration by a variety of independent researchers, but without satisfactory depth and explanation to the issue. This proposed project will be the first to apply a comprehensive multidisciplinary approach, exploiting techniques developed especially in the sub-discipline of Landscape Archaeology, in which the rural and urban worlds are analysed as a single unit, and thus as part of a single reality in transformation. Hispania provides an ideal ‘test-bed’ for the study given the results of new fieldwork, an availability of relevant sites (urban/rural), and recent published outputs. The applicant and the proposed Host (University of Leicester) and Partner Organizations (the CSIC-National Research Council of Spain and CINECA of Italy) can draw upon a rich vein of expertise, specialists, research, publications, equipment and infrastructure to generate data, models and results for this project. The approach to be developed will be of major value for addressing other aspects of Roman-late antique transformation in Hispania (urban, rural, social, demographic, economic), but, crucially, will also provide guidelines for analyses elsewhere in the Empire, thus enabling much closer dialogue in approaches and debates both for Late Antiquity and for other periods.

Keywords: late antiquity,hispania,landscape archaeology,urban centres,rural landscape,scientific visualization,spatial analysis,multidisciplinary approach
Oscillatory long-Range Coherence in Attention (ORCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-01
End date: 2018-11-20
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Attention -the ability to focus selectively on task relevant information and resist distraction- plays a critical role in many everyday life situations, such as in school or while driving. With an almost constant stream of information reaching us through smart phones and computers, our world becomes increasingly distracting, requiring enhanced attentional capabilities. This calls for new approaches to improve attention, also benefiting patients populations suffering from attention deficits. Is it possible to safely improve attention without medication? And how does the brain actually guides attention and resist distractions? The proposed research aims to answer these questions by combining a novel brain stimulation technique, transcranial alternating current stimulation (tACS) with state of the art neuroimaging methods. It will specifically test the intriguing hypothesis that attention can be enhanced by synchronizing rhythmic activity between two brain regions previously shown to be involved in attention. In the first study I will assess the effects of stimulation on attention performance, while simultaneously measuring neural activity using electroencephalogram (EEG). This will allow me to determine to what extent tACS can improve attention and investigate the causal role of neural oscillations in attention. In the second study, tACS will be combined with functional magnetic resonance imaging (fMRI) allowing to bridge the literature on neural oscillations (derived from EEG research) and attention networks (derived from fMRI research). Specifically, it will provide novel insights into the exact neural network subserving oscillatory activity associated with attention. Taken together, this project will not only investigate an innovative way to improve attention, with important implication for future clinical studies, but will also have a major contribution to cognitive neuroscience theories of attention.

Keywords: attention,neural networks,brain stimulation,neuroimaging
Investigation of the role of CYLD in Chronic Lymphocytic Leukaemia (CIRCLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-15
End date: 2018-04-14
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

This project will investigate the role of CYLD in Chronic Lymphocytic Leukaemia (CLL). CYLD is a deubiquinating enzyme acting as a tumour suppressor in numerous tumours. CLL is characterized by the accumulation of B-lymphocytes. It affects mostly the elder and has a high incidence rate in Europe. Recent data from CYLD knockout murine models indicate a link between CYLD and CLL, however the approach used for generation of these mice led to contrasting results. At the core of this interdisciplinary project is the generation of two transgenic murine with: i) targeted CYLD inactivation in B-lymphocytes, ii) targeted inactivation combined with a murine model of CLL. Targeted inactivation will be achieved using the Cre-Lox system, by crossing already available progenitor mice. The mice will be extensively characterized with an emphasis on B-lymphocytes development and pathophysiology. RNA-seq will be used to find differentially expressed genes in B-lymphocytes. Computational biology approaches will then be applied to identify the affected pathways, which will be evaluated against publicly available human CLL data, seeking wider consensus. CYLD targeted inactivation allows for the first time evaluation of CYLD's role in B-lymphocytes development and CLL ruling out the effect CYLD inactivation in other cells may have. This project will enable better understanding of the role of CYLD in B-lymphocytes biology and could unravel novel biomarkers and therapeutic targets. At the same time the applicant will train-through-research, master novel techniques and develop soft skills valuable for his future career. This project combines the applicant’s expertise in the generation and characterization of murine models with targeted CYLD inactivation with the host's long track record in B-lymphocytes and CLL.It falls well within the EU’s research agenda, which emphasizes interdisciplinary research leading to recognition of common disease mechanisms and identification of novel biomarkers.

Keywords: cyld,animal model
Regional Aircraft (REG GAM 2018)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,Italy,Italy,Germany,Spain,Spain,Spain,Italy,Italy,Germany,Italy,Italy,Italy,Italy,Belgium,Greece,Belgium,France,France,France,France,Netherlands,Netherlands,United Kingdom,Portugal,United Kingdom
Call: Regional Aircraft (H2020-IBA-CS2-GAMS-2017, 2017)
Start date: 2014-01-06
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 67289236.75375
EU funding (EUR): 50224604.46
Participants: 38
Project status: CLOSED

An aircraft that can transport between approximately 100-130 passengers, and is intended for short and medium haul flights can be considered to be a Regional Aircraft. The challenge is to improve the passenger experience so that regional aircraft offer a comparable level of inflight comfort, free from noise and vibration, with a comfort level comparable or better than today’s modern jets and with a reliability of service well beyond today’s service into small and regional airports.

Keywords: regional aircraft,short and medium haul flights,inflight comfort,noise and vibration reduction,service reliability
mesoscale multi-mode MRI of molecular targets (MAGNIFISCENT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2025-12-31
Duration (months): 72.0
Total project cost (EUR): 1946250.0
EU funding (EUR): 1946250.0
Participants: 1
Project status: SIGNED

Imaging defined cells, over extended time, depends on signal strength, stability, accessibility and specificity. Whereas light-microscopy (LM) can provide these, it does not allow imaging of entire intact tissues; imaging-depths and area-size are restricted, and not easily obtained through skin and bone. Magnetic Resonance Imaging (MRI) outperforms LM in these instances; providing images of large-fields-of-view (i.e., mesoscale), at any depth, easily across bone. Nevertheless, MRI suffers from low signals, spatial resolution and cannot detect specific biological targets. To remedy these shortcomings, and significantly extend the capabilities of MRI, we propose a novel chemo-genetic approach—MAGNIFISCENT (MAGNetic Including Fluorescence Imaging of Select Cells with ENzymatic Tags)—to jointly image multiple defined cellular-targets by MRI and LM. In parallel thrusts, we will synthesize a novel family of multifunctional, membrane-permeable, liganded-Contrast-Agents (CA; patented) that irreversibly bind original genetically-encoded enzymatic tags (eTags). When several eTags are expressed in various cells, each will bind its corresponding liganded-CA bearing a unique MRI-signature (‘color’); affording multicolor-MRI of the brain. To mitigate hurdles of expression, we introduce enrichment, an elegant scheme to increase binding-surface for MFS-agents. We estimate it to increase resolution of MRI to the single-cell level. Lastly, developing split-eTags will enable imaging cellular interactions of up to four different cellular populations jointly, a feat never shown before for MRI. We develop an innovative targeted-recombination scheme to ENTRAP neurons destined for apoptosis; a hallmark of neurodegeneration. Together, when combined, select targets will be irreversibly ‘tagged’ for long-term multimodal imaging at high resolutions. The multidisciplinary nature of my group ensures our success in developing this versatile technology for studying the brain in health and disease.

Keywords: chemo genetic,contrast agents,genetically encoded reporters,targeted recombination
Youth Skills (ySKILLS)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Estonia,Italy,Belgium,Norway,Belgium,Finland,Poland,Belgium,Czechia,Netherlands,Denmark,United Kingdom,Portugal
Call: The impact of technological transformations on children and youth (H2020-SC6-TRANSFORMATIONS-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 3188703.5
EU funding (EUR): 3188703.5
Participants: 16
Project status: SIGNED

ySKILLS starts from the observation that digitisation is changing society and requires a new set of digital skills, which many children and adolescents currently do not master. This can negatively affect their educational, informational and social inclusion and wellbeing. Longitudinal and robust academic research on children’s and adolescents’ digital uses, the use context and its impact is lacking on national and European levels. ySKILLS examines risks and opportunities related to children’s and adolescents’ (aged 12 to 17) ICT uses and their digital skills to understand how to purposefully use ICTs towards greater cognitive, physical, psychological and social wellbeing. We offer a critical perspective on the notion of skills itself: by extending traditional conceptions of skills, by recognising children’s critical views on their skills as young citizens with agency, voice and rights. ySKILLS will predict which children are more at risk of having low levels of wellbeing because of their ICT use, and to understand how digital skills can function as building resilience against negative impacts. This results in a comprehensive, evidence-based explanatory and foresight model predicting the complex impacts of ICT use on children’s and adolescents’ wellbeing in Europe, and the role of digital skills that can enhance their wellbeing. ySKILLS will conduct a longitudinal three-wave survey in six countries, selected based on their ranking as low, medium and high on the 2018 Digital Economy and Society Index. Adding to this survey, cognitive wellbeing will be investigated with fMRI in two countries. ICT use patterns will be analysed among at-risk groups in in-depth studies in six complementary countries. Through an effective dissemination strategy and practice and policy recommendations, framed in terms of children’s rights, the interdisciplinary ySKILLS consortium will strengthen the necessary interaction among the relevant stakeholders and practitioners involved.

Keywords: digital skills measurement,wellbeing,children and adolescents,ict use,multi method approach,at risk groups,longitudinal survey,in depth studies,children as active agents,foresight modelling