Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploration below the tip of the microtubule (ICEBERG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-10-01
End date: 2024-05-31
Duration (months): 68.0
Total project cost (EUR): 1998227.0
EU funding (EUR): 1998227.0
Participants: 1
Project status: SIGNED

Microtubules (MTs) are dynamic cytoskeleton filaments. They permanently transit between growth and shrinkage. This famous “dynamic instability” is governed by the addition and loss of tubulin dimers at their tips. In contrast to the tip, the MT lattice was considered to be a passive structure supporting intracellular transport. However, we recently found that MT lattice is dynamic and active! Actually, tubulin dimers can be exchanged with the cytoplasmic pool along the entire length of the MT. These incorporations can repair sites on the lattice that have been mechanically damaged. These repair sites protect the MTs from depolymerisation and increase the MT’s life span. This discovery opens up a new vista for understanding MT biology. First, we will investigate the biochemical consequences of MT-lattice turnover. We hypothesise that tubulin turnover affects the recruitment of MAPs, motors and tubulin-modifying enzymes. These recruitments may feedback on lattice turnover and further regulate MT life span and functions. Second, we will investigate the mechanical impact of the MT-lattice plasticity. Tubulin removal is likely to be associated with a local reduction of MT stiffness that can impact MT shape and the propagation of forces along the lattice. We anticipate that such effects will require us to reformulate the biophysical rules directing network architecture. To achieve this, we will use reconstituted MT networks in vitro to investigate the molecular mechanism regulating MT-lattice plasticity, and cultured cells to test the physiological relevance of these mechanisms. In both approaches, microfabricated devices will be used to control the spatial boundary conditions directing MT self-organisation. By exploring the hidden 90% of MT iceberg we aim to show that the MT lattice is a dynamic mechano-sensory structure which regulates interphase MT-network architectures and possibly confers them unexpected functions.

Keywords: microtubules,actin,cell mechanics,cell polarity,hematopoietic stem cell
PLatform based on Emerging and Interoperable Applications for enhanced Decommissioning processES (PLEIADES)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Decommissioning and environmental remediation
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Belgium,Norway,Finland,Norway,Slovakia,France,France,France
Call: Fostering innovation in decommissioning of nuclear facilities (NFRP-2019-2020, 2019)
Start date: 2020-10-01
End date: 2023-11-30
Duration (months): 38.0
Total project cost (EUR): 4348848.58
EU funding (EUR): 2800000.0
Participants: 15
Project status: SIGNED

Dismantling and decommissioning (D&D) of nuclear facilities enters an important period covering initiatives driven by different countries to strengthen safety measures and maintaining the operation financially viable. The representatives of industry, research, safety organization and technological SMEs join forces in this project to demonstrate an innovative BIM modelling-based approach for detailed planning of logistics, resource allocation and safety measures from a holistic perspective on carefully selected pilot plants. As compared with traditional decommissioning projects, D&D of nuclear facilities is a complex task due to specific logistical and coordination requirements, budgetary constraints and long-term time frames. Considerable uncertainties of these factors, combined with high-level safety requirements related to management of radiological material, calls for an innovative approach. While traditional methods applying mostly manual procedures for planning of individual tasks within the overall process, such methods prove inefficient for enabling integrated planning across the whole project and team. 3D modelling-based digital concepts have potential to both simplify D&D planning, and to lead towards more efficient and better-coordinated actions. The project outcomes shall result in a mature platform based on a BIM approach, integrating a software suite, including emerging tools and digital solutions provided by PLEIADES partners and interconnected together. Within this platform, the main issues of a dismantling site will be treated and optimized. The project will develop a common core, on which all the software modules can connect, retrieve input data, calculate simulation results and share up-to-date data, in particular scenario feasibility, waste estimation, radiation exposure, cost and duration. The platform will be evaluated on several real decommissioning projects of different natures, such as a research reactor and a commercial power plant.

Keywords: dandd,platform,decommissioning,dismantling
Enlightened trust: An examination of trust and distrust in governance – conditions, effects and remedies (EnTrust)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Belgium,Greece,Poland,Serbia,Czechia,Denmark
Call: Trust in governance (H2020-SC6-GOVERNANCE-2019, 2019)
Start date: 2020-02-01
End date: 2024-01-31
Duration (months): 48.0
Total project cost (EUR): 2978151.25
EU funding (EUR): 2978151.25
Participants: 8
Project status: SIGNED

In EnTrust, we will provide novel insights into trust in governance and measures to support sustainable and democratic societies in Europe. Our project has five overarching objectives: a) Develop a multidisciplinary theoretical framework to understand the dynamic relationship between trust and distrust, in order to promote new forms of enlightened trust in democratic governance; b) Provide a comprehensive empirical dataset based on mixed methods and geared to measure how trust and distrust are constructed at individual, meso, and macro levels in relation to governance actors across local, national and European levels; c) Systematically compare and map trust and distrust across European countries to understand context-specific forms of trust and distrust, their conditions and consequences; d) Develop role models and best practices enabling to promote enlightened trust; and e) Engage in active exploitation, dissemination and communication activities to reach the highest possible impact of our findings. EnTrust consists of an interdisciplinary and well-integrated consortium of seven research teams from the Czech Republic, Denmark, Germany, Greece, Italy, Poland and Serbia with expertise in sociology, psychology, political science, media and communication studies, as well as a civil society practitioner active at the EU level. Our work plan will generate novel theoretical and empirical insights on the basis of interlocked methods, including in-depth interviews and focus groups with citizens and governance actors, analyses of online and social media content, as well as a representative population survey and various experiments. Moreover, it will make use of innovative instruments to secure a high level of dissemination, exploitation and communication. Our goal is to provide tangible and viable recommendations for policymakers, civil society actors and the scientific community to improve trust relations.

Keywords: trust,distrust,determinants,practical implications,remedies,risk analysis,prevention,policy recommendations,public opinion,civil society,public sphere,social media,civic dialogue
DISC care™ , the Hernia Blocking System to prevent Lumbar Disc Re-Herniation (DISC care)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-01-01
End date: 2023-04-30
Duration (months): 28.0
Total project cost (EUR): 2763675.0
EU funding (EUR): 1934572.5
Participants: 1
Project status: SIGNED

Lumbar disc herniation occurs when the intervertebral disc breaks and its nucleus bursts out pressing the nerves. It causes extreme back and leg pain, numbness and disability. To relieve the pain, a surgical intervention (discectomy) is the standard of care, consisting of removing the herniated material. Disc herniation is the most frequent cause of spine surgery for working-age patients and in 2019 more than 1M lumbar discectomies were performed WW. Although discectomy may work in some cases, a high portion of patients have a high risk of re-herniation through the same disc defect, requiring a costly and complex re-operation. To avoid re-herniation, some surgeons remove a larger amount of nucleus, making it unlikely to re-herniate, but compromising the disc functionality and causing chronic back pain. NEOS Surgery has developed the DISC care™ Hernia Blocking System, an implantable strong barrier that prevents re-herniation while allowing surgeons to remove the minimum disc tissue. DISC care™ will solve an unmet clinical need while reducing healthcare costs. The internationally patented DISC care™, has completed several years of development and pre-clinical testing with excellent results. The product is now ready to overcome the final barriers for its market launch in 2023: clinical trial, complete product range and CE-marking under the new EU MDR. The DISC care™ will enter a “Blue Ocean” market segment, being the first Hernia Blocking device from a European company and the second worldwide. The DISC care™ will radically impact NEOS turnover, with an exponential growth 2027. Moreover, it will accelerate NEOS growth, creating a very profitable financial structure for future expansion. NEOS multidisciplinary team will be key for the DISC care™ success: we have the experience to transform an idea into a global commercial medical device, thanks to our current line of cranial closure devices.
From the origin of Earth's volatiles to atmospheric oxygenation (O2RIGIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2021-08-31
Duration (months): 78.0
Total project cost (EUR): 1498353.0
EU funding (EUR): 1498353.0
Participants: 1
Project status: CLOSED

Aim of this project is to understand the connection between endogenic and exogenic processes of our planet that led to the redox contrast between Earth’s surface and interior. For this purpose the time constraints on atmospheric oxygenation can be refined and for the first time linked with a new approach to Earth’s endogenic processes like plate tectonics, mantle melting, volcanism, continent formation and subduction-related sediment- and crust recycling. These objectives will be achieved by using the unique geochemical capabilities of the selenium (Se) isotope system to unlock the geological record of changing oxygen fugacities in the mantle-crust-atmosphere reservoirs. The power of the Se isotope system lies in its redox sensitivity and in the volatile and highly siderophile/chalcophile character of elemental Se. This links Se to the evolution of other volatiles during key geological processes from Earth formation ca. 4.5 Ga ago until today. The occurrence and behavior of Se is fully controlled by accessory micrometric sulfide minerals in the silicate Earth, which may conserve their original Se isotopic signatures over large geological timescales and can be dated via the 187Re-187Os geochronometer. This offers high resolutions in time and space that are groundbreaking for research on Earth System Oxygenation. Covering Earth geologic history, new high-precision Se isotope data of the sedimentary and representative mantle-derived magmatic rock record from all major plate tectonic settings will be combined with the mineral-scale record of robust and global “time capsules” such as diamond inclusions. Once the evolution into todays dynamic Earth’s Redox System is understood, the investigation will be pushed back in time to Earth’s formation. This involves a reconciliation of the meteoritic and Archean rock and mineral-scale Se isotope record to constrain the origin of volatiles essential for the oceans, generation of an atmosphere and development of life on our planet.

Keywords: volatiles,mantle evolution,earth system oxygenation
Universal Smart Hypodermic Needle for preventing reuse and accidental pricks (SHN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

VASTAGO INTERNATIONAL Ltd emerged with the aim of developing a new technology that solves the problems associated with reuse or share syringes and accidental needlestick injuries causing millions of deaths since the spread of infectious diseases. The creation of Smart Hypodermic Needle (SHN) solves these problems in a safe, cost effective way and adaptable to the most syringes of the marker according to the international LUER system. This device provides a high added value in biosecurity since its innovative biopolymer membrane and the self-retracting mechanism makes it automatic and retractable needle which is activated after its use independently of operator´s will. The overall objective of the SHN project is the industrial adaptation and the process scale-up for manufacturing the safety needle to implement it at the clinical level. Currently, the SHN prototype has a technology level TRL6 and it has been validated through trials simulating medical treatments procedures demonstrating their efficiency and viability. However, the company needs to work in the implementation of the business model, in the industrial adaptation of our prototype and, in achieving the certification of our system to be commercialized. The initial plan to commercialize the SHN consists in the combination of own production with a partner plus licensing of the technology. According to our estimation, the cumulative cash flow projected by VASTAGO INTERNATIONAL at year 5 will amount €52.6 M meaning a ROI of 219%.

Keywords: security syringe,self retracting mechanism,biopolymer membrane,pasive action
Algae for a biomass applied to the production of added value compounds (ABACUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Spain,Germany,France,France,France,France,United Kingdom,Portugal
Call: Exploiting algae and other aquatic biomass for production of molecules for pharma, nutraceuticals, food additives and cosmetic applications (H2020-BBI-JTI-2016, 2016)
Start date: 2017-05-01
End date: 2020-07-31
Duration (months): 39.0
Total project cost (EUR): 5135861.16
EU funding (EUR): 4653658.66
Participants: 9
Project status: CLOSED

ABACUS gathers 2 large industries, 3 algae SMEs and 4 RTOs. It aims at a business-oriented and technology-driven development of a new algal biorefinery, thereby bringing to the market innovative algae-based ingredients for high-end applications, spanning from algal terpenes for fragrances to long-chain terpenoids (carotenoids) for nutraceuticals and cosmetic actives. One key objective of ABACUS is to obtain more than 10% photosynthates of targeted terpenoids. For this purpose, ABACUS selects and optimizes unique algae strains from 4 large culture collections owned by project’s partners. Moreover, ABACUS focuses on optimizing cultivation steps and mastering production of target products by online monitoring and automated control of photobioreactors with the development of specific sensors for terpenes and for the parameters relevant to terpene’s production (light, PO2, PCO2, nutrients). ABACUS investigates the fractionation steps to provide green low-cost downstream processing with a view to reduce operational expenses of the whole production line. Life cycle analysis and techno-economic analysis are fundamental guidelines of ABACUS’s developments to ensure that technologies and products are economically and environmentally sustainable. Applicability of targeted ingredients is assessed by the industrial partners (SMEs and large industries with established access to markets) considering cosmetic and nutraceutical applications. ABACUS aims to demonstrate biorefining processes allowing valorizing up to 95% of the algal biomass into high value ingredients and by-products. EU standards and market regulations associated to innovative bioprocesses and new ingredients are reviewed in order to demonstrate the acceptability of the ABACUS biorefinery. ABACUS key advantage lies in its business-oriented workplan, gathering key players along the whole product development chain and incorporating most-advanced technologies for efficient growth and fractionation of microalgae.

Keywords: terpenes,carotenoids,algae,photobioreactors
Multimodal magnetic cellular-patches with synergistic effects for high performance theranostics (MAGNET-CELLPATCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The key goals of the MAGNET-CELLPATCH project are: a) the training of a talented experienced researcher, Dr. Castellanos-Rubio, in the fast growing fields of nanotechnology, microfabrication, biomedicine and healthcare industry, in which the host and partner institutions have an extensive knowledge and expertise; and, b) the development, optimisation and evaluation of cost-efficient multimodal magnetic cellular-patches for high performance theranostics. The interdisciplinary training program includes the use of advanced characterisation techniques, as XAS and SAXS, and the evaluation of the material in therapy (hyperthermia-chemotherapy) and diagnosis (MRI) of colorectal cancer. The fellow is a skilled researcher that during her undergraduate and postgraduate career has gained strong experience in the fabrication and characterization of biocompatible magnetic nanoparticles and inorganic-polymeric microstructures with magnetothermal properties. To further boost her career, she needs to gain expertise in sophisticated data-capture instrumentation (such as synchrotron radiation sources), in in-vitro and in-vivo experimental studies and in MRI technique, in which the UPV/EHU has a world-recognised expertise. Moreover, through secondments at academic and industrial co-hosts, at the UCL and NIT respectively, she will gain additional training in preclinical experiments in the field of magnetic-drug-targeting and in production protocols of medical devices, scaling-up options, cost-reduction strategies, quality-controls and market-ready items designs. This multidisciplinary project explicitly addresses a world-wide societal challenge in health, namely, the development of new materials for cancer treatment. In addition, it will also increase the fellow´s supervision and teaching experience, project and intellectual property management expertise, research funding and proposal writing, which will assist her in acquiring necessary competences to reach professional maturity.

Keywords: magnetic nanoparticles,two dimensional microstructures,photolitography,layer by layer,magnetic hyperthermia,magnetic targeting,drug delivery
Containment, Avalanches and Optimisation in Spreading-processes (CAOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Spreading processes, such as cascading failure of technological networks, epidemic outbreak and contagion in social networks are ubiquitous and have a significant impact on the modern society. In many cases, transitions to large-scale blackouts or global pandemics occur abruptly due to tiny changes in system parameters; epidemics and social movements can spread out explosively, forming avalanche-like outbreaks in a very short period. The drastic transitions are beneficial for making global impact of boosting charity campaigns and commercial advertising but can also have catastrophic consequences when epidemics or failures spread to large part of a critical systems abruptly, without any early warning signals. Moreover, multiple cooperative of competitive spreading processes make the picture even more complex. Previous work in this area focused on the asymptotic manifestation of the process and typically ignored the interplay between specific system topology and the dynamics. Methods to monitor, identify and control drastic transitions and outbreaks in heterogeneous realistic networks are lacking. In this project, we will investigate the signs for abrupt transitions and avalanche outbreaks both macroscopically and in specific instances, to gain insight into the conditions for their onset. We will develop methods to contain (or facilitate) the outbreaks by optimal deployment of resources, such as applying vaccines or distributing promotion material by employing the recently developed dynamic message passing techniques from statistical physics. We will collaborate with British Telecom to promote product marketing and service provision by using the new optimisation algorithms. This project will have significant impact on the scientific understanding of non-equilibrium spreading processes, provide algorithmic solutions for practical problems in specific instances, will support policy making decisions and offer optimal resource allocation for commercial marketing tasks.

Keywords: epidemic spreading,social contagion,percolation transition,cavity method,dynamic message passing,computational epidemiology,commercial applications,viral marketing