Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Next Generation of Carbon for the Process Industry (CarbonNext)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Coordination and support actions
Countries involved: Germany,Netherlands,United Kingdom
Call: Potential use of carbon dioxide / carbon monoxide and non-conventional fossil natural resources in Europe as feedstock for the process industry (H2020-SPIRE-2016, 2016)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 495747.5
EU funding (EUR): 495747.5
Participants: 3
Project status: CLOSED

The process industries and other crude oil consuming sectors are heavily dependent on fossil inputs for both carbon feedstock and energy, with the consequential CO2 emission problems and import dependency as a result. To be prepared for a future with significantly reduced emissions they are seeking alternative carbon sources to replace traditional fossil fuels. The objective of the CarbonNext project is to evaluate the potential use of CO2/CO and non-conventional fossil natural resources as feedstock for the process industry in Europe. The work will examine the existing and expected sources of CO2 and CO as well as non-conventional fossil natural resources such as shale gas, tar sands, coal bed methane, gas to liquid, and coal to liquid technologies. Results of the project will include the identification of value chains within processes and where industrial symbiosis can be valuable (chemistry, cement, steel, etc.). The CarbonNext project will inform, as a basis for decision-making, Europe’s SME’s, large industry and policymakers with an enhanced understanding of the impact and opportunities for new sources of carbon for the processing industry. CarbonNext will primarily focus on new sources of carbon as a feedstock and secondarily the impact on energy availability, price and emissions. The CarbonNext consortium brings together three of the leading organisations in the field of carbon dioxide/carbon monoxide utilisation. The knowledge base that each member brings is as a leader in the field and is therefore exemplary. CarbonNext will build on the project team achievements in the FP7 project SCOT (Smart CO2 Transformations), the BMBF funded coordination project CO2Net, the CO2Chem network and many climate and energy related projects in Europe and for the European Commission.

Keywords: carbon sources
Understanding the dynamics of the immune system to cure graft-versus-host disease (GvHD). (GvHDCure)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-03-01
End date: 2021-05-31
Duration (months): 63.0
Total project cost (EUR): 1987500.0
EU funding (EUR): 1987500.0
Participants: 1
Project status: CLOSED

Acute graft-versus-host disease (GvHD) is the leading cause of the high mortality of patients having undergone allogeneic hematopoietic cell transplantation. A key event in the pathogenesis of GvHD is the injury and loss of epithelial cells in the intestinal tract. The overall goal of GvHDCure is to identify the pathophysiological mechanisms that initiate (1), propagate (2) and maintain (3) GvHD. (1) We found that one of the earliest events during GvHD initiation is infiltration of the intestines by neutrophils. By using transgenic neutrophil cell lines carrying selective gene defects, we will systematically evaluate molecules in neutrophils that are critical for their sensing and effector function during GvHD in combination with novel imaging methods to track bacterial translocation. (2) The molecular programs propagating inflammation-induced epithelial apoptosis, endoplasmic reticulum stress and the sensing of DAMPs in GvHD are not understood. We will isolate enterocytes from GvHD mice to develop a precise quantitative genomic and micro RNA (miR) fingerprint of their death. The connection between ER stress and enterocyte death will be validated in intestinal organoid culture systems and in vivo in an XBP-1 mRNA splicing reporter mouse. In addition, we will make use of our human tissue bank, allowing the efficient genetic screening and verification of regulatory molecular networks in the cells from GvHD patients. (3) Maintenance of GvHD relies on continuous immune cell activation. Based on our miR array and phospho-proteomics data set, we will selectively analyze the role of several miRs and kinases in neutrophils, dendritic cells, T cells and enterocytes for GvHD maintenance by using multiple Cre-lox mice and kinase inhibitors to manipulate GvHD. Via a combination of murine and human studies GvHDCure aims to directly develop individualized therapeutic strategies to interfere with GvHD at multiple levels to make allo-HCT more safe for patients with blood cancer.

Keywords: graft versus host disease,allogeneic hematopoietic stem cell transplantation
CAR-T cell therapy targeting carbohydrates in cancer (SweetCAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-10-01
End date: 2022-04-30
Duration (months): 19.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Major limitations in current immunotherapy success are low antigenicity of targeting antigen and tumor heterogeneity. Hence there is an unmet need for novel antigen targets that could potentially be expressed on many tumor types. Cancer express aberrant cell surface glycosylation patterns compared to normal cells. These tumor-associated carbohydrate-neoantigens can be targeted for tumor cell killing by antibodies and cytotoxic immune cells. Sialic acids cover cell surface glycans and frequently have altered expression on many types of carcinoma cells and correlate with cancer progression and/or metastasis. We aim to focus on targeting sialic acid containing carbohydrate-neoantigens using the chimeric antigen receptor T cell (CAR-T) immunotherapy approach. Current clinical CAR-T cells target mostly soluble tumors using CD19, BCMA and other non-cancer specific antigens that often suffer toxicity and side effects. Our universal anti-carbohydrate CAR-T approach could target many types of carcinomas with high specificity and safety, and could potentially reach patients rapidly.

Keywords: immunotherapy,glycobiology,carbohydrate,antibodies,chimeric antigen receptor car,car t cell therapy,cancer,solid tumors
Understanding unconventional superconductivity in twisted flatlands (SuperTwist)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany,Spain
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1780728.0
EU funding (EUR): 1391978.0
Participants: 2
Project status: SIGNED

It is widely believed that the development of room temperature superconductivity is one of biggest challenges of modern physics and will lead to a technological revolution. However, a detailed understanding of how high temperature superconductivity arises in unconventional superconductors has to this day eluded scientists. This year, in a breakthrough discovery, scientists have found superconductivity in a radically new compound, which has a strikingly similar phenomenology to most unconventional superconductors – “magic” angle bilayer graphene. As graphene crystals are ultra-clean, highly tuneable and its parent state is well understood, I strongly believe that the study of these compounds will cause a long awaited revolution in the comprehension of unconventional superconductivity. In this project I will uncover the nature of superconductivity in “magic” angle graphene, by experimentally revealing its defining aspect – the superconducting order parameter. While no experimental method alone can definitely define the order parameter and since key experimental techniques are unavailable for these truly nano-scale materials, I will implement a radically new, multidisciplinary approach between material science and the development of disruptive measurement techniques. To achieve this ambitious goal, my truly unique background is essential, which includes van der Waals engineering, quantum transport, microwave engineering and quantum optics. I will employ these versatile skills to (i) develop robust procedures to engineer novel van der Waals hetero-structures of “magic” angle graphene to manipulate its phonons, impurities and magnetic correlations, (ii) perform Josephson interferometry and tunnelling experiments to investigate its macroscopic phase, spin state and excitation spectrum, (iii) develop novel thermal transport and specific heat techniques to investigate the size and nodal structure of its superconducting gap.

Keywords: unconventional superconductivity,graphene,van der waals,specific heat
USharePark: smart secUres system to SHARE PARKing places in private garages (USharePark)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

USharePark is a peer-to-peer (P2P) smart parking solution intended to optimize the usage of available private parking spaces. This business project is driven by two Spanish companies, Ayanet and Garage Scanner. The first of them is a company with more than 30 years of experience in SW and ICT solutions. Garage Scanner is a technological start-up created in 2007, and it is the initiator of USharePark. Our alliance was motivated by the potential synergy, since Garage Scanner needs to develop certain tasks in those fields where Ayanet has expertise, and Ayanet seeks to diversify its line of business through USharePark. We have already signed a contract with an important parking lot owner in Spain to manage 600 parking spaces in three different facilities, starting in September 2015, and players in other cities and countries have shown interest in the system. The next step of our joint venture is to develop an international commercialization strategy which will enable the penetration in the key markets in Europe and US. The total smart parking revenue in these areas was estimated at €6.26 billion in 2014 and it is expected to grow at a CAGR of 17.9% to reach €38.25 billion in 2025. The specific P2P smart parking market is estimated to grow at a CAGR close to 30%, from €100 million to €1.87 billion during the same period. 57.24 million parking spaces are already offered by the top 20 app providers in these areas, on behalf of 29.65 million users. Therefore, we can assure that specific commercial opportunities will arise for parking operators like USharePark and their supporting ecosystem. Our solution connects drivers and parking owners to get the most of the availability of empty spaces. Owners receive an extra income by renting their parking spaces while not being used, and drivers save time, money and effort when needing a parking space. Besides, it allows minimising the traffic of vehicles in public roads, optimising the amount of polluting gases disposed.

Keywords: smart parking,smart cities,mobile parking reservation,parking spaces optimisation,parking spaces share
Multipurpose test rig for transmissions gearboxes. (MUTR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Czechia
Call: Multipurpose test rig for transmission gear boxes (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-09-01
End date: 2020-06-30
Duration (months): 46.0
Total project cost (EUR): 606400.0
EU funding (EUR): 606400.0
Participants: 1
Project status: CLOSED

Objective of this proposal is to design, manufacture, test and support the adaptation of the test rig used to develop the Drive System for Compound Rotorcraft Demonstrator in the frame of IADP FRC. Based on the topic description published in this call our proposal suppose interconnection of the lateral rotor gearboxes via vertical transmission shafting, supported on two or three auxiliary bearing housings, in order to lock the two gearboxes together. The transmission shafting is connected to the lateral gearboxes by means of bevel gearings. Between flanges of the transmission shafting is inserted special hydraulic torque loader which make it possible to impose static or variable torque on gearboxes during operation/rotation according to a test program. The imposed torque is proportional to the pressure of the feed-in oil supplied to the device via quill shaft. Due to the back-to-back or face-to-face architecture, required power imput covers just losses in the gears and transmission shafting. Aeronautical Research and Test Establishment (VZLÚ) is a national centre for research, development and testing in aeronautics and space. VZLÚ and the potentially participating team has experiences with design of test benches for aircraft gas turbine engines (historically M601, M602) and its components like 2 stage 2 shafts radial flow compressor, to mention recent project, these are design of the test rigs for long term evaluation of aircraft turboprop gearboxes (Arrius 1D, TP100, TS100), test bench for turboprop engine with propeller, design of the internal technology for turboprop engine test cell, experimental system for testing of gas turbine combustor segments under elevated temperatures and pressures. Work team is well experienced and equipped with modern CAD technology, CFD and FEM solvers, and has long time cooperation experience with aircraft gearbox manufacturers (e.g. PBS Velka Bites, GE Aviation Czech).

Keywords: test rig,gearbox,design,test,rotorcraft,manufacture sss
MoBile Robotic PlAtforms for ACtive InspeCtion and Harvesting in AgricUltural AreaS (BACCHUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Greece,Norway,United Kingdom,United Kingdom
Call: Robotics Core Technology (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-11-30
Duration (months): 47.0
Total project cost (EUR): 5104943.75
EU funding (EUR): 5104943.75
Participants: 8
Project status: SIGNED

With the growing population and climate change, agricultural productivity growth is unlikely to meet the increased demand for food. Besides the increasing pressure to produce more, there is an overall need for higher quality and sustainable cultivation. Precision agriculture combined with intelligent robotic technologies can push to that direction. The incorporation of such technologies into agricultural production not only benefits productivity but also improves the working conditions of farmers and labourers. Intelligent systems are becoming the go-to solution to push towards precision agriculture, while a large number of farmer operations are already transitioning to full autonomy. Smart, automated and selective harvesting, in particular, can provide considerable improvement in production leaving the unripe product in the field to mature. However, in order to achieve such automation significant progress is required regarding the cognitive and mechatronic capabilities of the robotic agents replacing the human workers in these tasks, especially in cases where human-like actions are required by the robots. BACCHUS intelligent mobile robotic system promises to reproduce hand harvesting operations, while at the same time take the manual legwork out by autonomously operating in four different levels: i) performing robot navigation with quality performance guarantee in order to inspect the crops and collect data from the agricultural area through embedded sensorial system; ii) performing bi-manual harvesting operations with the needed finesse using a modular robotic platform, iii) employing additive manufacturing for adjusting the robot gripper to the geometry of the different crops, iii) presenting advanced cognitive capabilities and decision making skills. The envisioned system will be demonstrated and evaluated in the challenging vineyard environment inspecting different types of vines and harvesting bunches of grapes of different varieties in a human-like manner.

Keywords: autonomous mobile robots,bimanual control,crop inspection,harvesting robots
Bioactive compounds from Olea europaea: investigation and application in food, cosmetic and pharmaceutical industry (Olive-Net)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Austria,Germany,Spain,Italy,Algeria,Spain,Thailand,Greece,Greece,Greece,France,France,France,France,Morocco
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1732500.0
EU funding (EUR): 1732500.0
Participants: 17
Project status: CLOSED

The goal of Olive-Net project is to introduce a novel approach for the exploration, valorization and marketing of new products based on bioactive compounds from Olea europaea. This will be achieved through an extended and well-balanced scheme of researcher’s secondments between universities and enterprises from EU & Associated countries as well as universities from Third countries. A mutual scientific project developed on the needs and interests of both sectors exploiting the existing expertise will be the base of this proposal. Products and side-products of the olive tree such as olive oil, edible olive fruits, olive mill waste and olive tree leaves, will be subjected to a series of state-of-the-art extraction and isolation cascades in order to provide extracts, enriched fractions and isolated compounds of high purity. Target chemical categories will involve the well known olive oil polyphenols and secoiridoids, that will be assessed for their safety and pharmacological effects against inflammation, osteoarthritis, cardiovascular disease, etc. in cell-based and in vivo assays. All active ingredients will be identified and characterized with advanced analytical techniques, in order to be integrated in formulations and products in the area of nutraceuticals/dietary supplements. Within this project, core scientific multidisciplinary knowledge from different research areas will be integrated creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different research orientation where complimentary skills are required. Special attention will be given to dissemination activities aiming to public awareness of benefits of healthy diet(s). Olive-Net aspires to create a successful model promoting considerably researchers’ competences and long-lasting collaboration between Industry and Academia.

Keywords: olea europaea,olive mill waste,olive oil,extraction,analysis,profiling,cosmetics,inflammation,in vivo,ageing,supplements,nutraceuticals,oleacein,oleocanthal,obesity
Octopus Technology: Shale gas and tight oil drilling technology evolution - 100’s micro laterals drilled simultaneously to maximise well productivity (Octopus Technology)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Octopus is a technology which will lead to the development of an economical, fast and environmentally sustainable alternative to fracking technologies. Fracking is an effective but controversial technology which uses hydraulic stimulation to boost productivity of oil or gas wells, and is currently used in 160,000 wells, worldwide. Fracking technology is surrounded by environmental, economic and political argument and there is rising concern over its use of billions of gallons of clean water which becomes polluted and is injected under pressure into the ground, a practice which is now known to trigger earthquakes. As an alternative to fracking methods, and with clear advancements over state-of-the-art (SOA) alternatives, Octopus is a spectacular drilling technology that can create 400 hundred micro laterals simultaneously in a matter of hours, leaving the mother bore full bore after the laterals have been drilled, enabling easy access in the future. These laterals emerge from a vertical or horizontal well bore which will help to achieve significant and sustained well productivity increases of 2 to 10 times and will enable wells to be completed 40 to 80 days sooner than existing multi-lateral well completion technologies. The principle Horizon project objective is to enhance the Octopus technology and demonstrate to the target market the efficiency and environmental improvements our technology offers over SOA alternatives and give full customer confidence in the Octopus technology. This feasibility study will allow us to complete a market study; identify suitable dead wells for Phase 2 trials; scope the legislative pathway; identify Phase 2 project partners; plan the work to be completed during Phase 2 and produce a fully elaborated business plan. Octopus advancements over SOA technologies will enable us to become a world technology leader in sustainable shale gas and tight oil extraction.

Keywords: advanced processing technology,shale gas,tight oil,drilling,laterals,well,sustainable energy,resource efficiency