Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative smart components, modules and appliances for a truly connected, efficient and secure smart grid. (CONNECT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Germany,Italy,Italy,Italy,Italy,Italy,Italy,Germany,Italy,Italy,Spain,Germany,Slovakia,Slovakia,Netherlands,Netherlands,Netherlands
Call: ECSEL Key Applications and Essential technologies (RIA) (H2020-ECSEL-2016-1-RIA-two-stage, 2016)
Start date: 2017-04-01
End date: 2021-01-31
Duration (months): 46.0
Total project cost (EUR): 17351806.23
EU funding (EUR): 5146307.140000001
Participants: 27
Project status: CLOSED

CONNECT aims to provide concepts, technologies and components that support enhanced integration of renewables and storage combined with intelligent control of the power flow. The demand for primary energy and the carbon dioxide emissions will be reduced and a decentralized energy infrastructure will be facilitated by these solutions. CONNECT investigates new concepts and technologies for power conversion that will be specifically developed for bidirectional power exchange with the grid and for controllable power flow in order to support the extended integration of renewables like PV and local storage. Power quality optimization will be explored in order to avoid unnecessary energy flows in the grid. The enhanced capabilities of the power conversion fit seamlessly to the smart energy management systems researched in CONNECT applicable for single/multiple buildings and quarters. Monitoring approaches and advanced control algorithms will be developed which take into account renewable energy sources, local storage and electric vehicles for peak demand reduction and optimization of local generation, consumption and storage. In order to fully exploit the advantages of the aforementioned technologies it is necessary to enhance the data transmission capacity of the smart grid communication infrastructure. For this purpose CONNECT will develop solutions for high interoperable, high data rate local and wide area communication in the grid with enhanced security in order to protect this critical infrastructure against attacks. Particular effort is spend to minimize the power consumption of the developed solutions. Selected results of CONNECT are planned to be demonstrated not only in lab environment but also in close to real life scenarios.

Keywords: power conversion,energy management,local storage,smart grid,dc micro grid,energy efficiency,energy system,security,smart meter,distributed energy resources,low power,communication
The worldwide first hybrid multi-functional municipal vehicle for a significant reduction of greenhouse gas emissions, fine particles and noise pollution in cities (Hybrid Drive)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 2840187.5
EU funding (EUR): 1988131.25
Participants: 1
Project status: CLOSED

Holder is an innovative and highly awarded SME with a very long history in the development and production of special vehicles. In the more than 125 years long company history, several market-disrupting technologies have been developed.The main foundation for nowadays success was laid in 1954, when the company developed and introduced articulated steering. With this technology, Holder became world renowned in the segments for municipal vehicles, viticulture and horticulture. Today, Holder vehicles are sold in more than 50 countries worldwide and the company is market leader for multi-purpose vehicles with articulated steering. Building on the know-how and market position, Holder will now introduce the next breakthrough into the market: The Holder Hybrid Drive for lowest emission multi-purpose vehicles with articulated steering. This will allow the combination of an electric power source with a range extender for heavy work as well as a combination of different drive sources. With this innovative solution, Holder directly addresses a quickly emerging customer need: current municipal vehicles are solely powered by diesel engines, which are associated with NOx and PM emissions and thus, more and more affected by strict regulations. Cities and municipalities are therefore looking for clean and sustainable solutions to improve their air quality and fulfil all legal requirements without impeding their everyday work. This need will be fulfilled by Holder Hybrid Drive. Thus, Holder plans to subsequently equip all vehicles with the Hybrid Drive technology to generate a competitive edge and further extent the market leadership. For the initial market introduction, Holder addresses the European market for municipal services. The global distribution network will help to quickly enter the market and generate relevant market shares. With the commercialisation of Hybrid Drive, Holder plans to generate an additional turnover of at least 33 million € in 2023 and 45 new positions.

Keywords: hybrid,drive,municipal,vehicle,articulated steering,multi purpose,electric,emission,city,pollution,particulate,matter,fine,particles,noise,cities
Studying brain representations as a distributed process: from neural code to behavior (DistriBrainRep)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-06-15
End date: 2021-06-14
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

We know coffee not only by its taste, but also by its name and association with caffeine. How our brains enable this association between stimulus-aspects and guides our behavior accordingly (e.g. determining whether we should drink coffee or discuss it) is one of the core questions of cognitive neuroscience. Neuroimaging research of brain activity indeed confirm that the brain simultaneously processes stimuli across distributed areas, each selective for a specific stimulus aspect. However, the computational research of stimulus representations (how fine-grained activity patterns relate to specific stimuli), is currently constrained to the detailed inspection of isolated brain areas. The proposed project offers a new formalism and method that may link these two research streams, initiating the study of representations as a distributed neural process. By combining the computational and experimental knowledge of the host with the functional Magnetic Resonance Imaging (fMRI) expertise of the researcher, the proposed project aims to reveal: 1) what computational principle underlies representations of different stimulus-aspects across brain areas, 2) whether distributed representations can co-express to form an overall knowledge of a stimulus, and 3) what mechanism regulates the expression of representations to allow flexible behavior. These questions will be addressed by studying brain activity evoked by stimuli composed of multiple aspects (visual, phonetic, associative) and by drawing from fMRI, brain stimulation and computational methods. Hence, the proposed work will provide the researcher with diverse training-through-research and a platform for establishing interdisciplinary collaborations. Expected results may bridge between the two major streams of cognitive neuroimaging to form a new understanding of how neural computations underlie distributed cognitive processes, which in turn gives rise to complex human behavior.

Keywords: fmri,tdcs,brain representations,resting state,efficient coding
Testing Hydrogen admixture for Gas Applications (THyGA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Italy,Germany,Germany,Belgium,France,France,Netherlands,Denmark
Call: Hydrogen admixtures in natural gas domestic and commercial end uses (H2020-JTI-FCH-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-03-31
Duration (months): 39.0
Total project cost (EUR): 2468826.25
EU funding (EUR): 2468826.25
Participants: 9
Project status: SIGNED

THyGA main goal is to enable the wide adoption of hydrogen and natural gas (H2/NG) blends by closing knowledge gaps regarding technical impacts on residential and commercial gas appliances. For this purpose, THyGA will: •Screen the portfolio of technologies in the domestic and commercial sectors and assess theoretically the impact of hydrogen / natural gas admixture in order to have a quantitative segmentation of the gas appliance market and a selection of the most adequate products to be tested •Test up to 100 residential and commercial gas appliances (hobs, boilers, CHP, Heat pumps, etc.) and how 200 Million of European gas appliances will react to various H2 concentration scenarios •Benchmark and develop pre-certification protocols (test gases) for different level of H2 in natural gas for coming integration in standardization, these protocols will be validated through tests •Make recommendations for manufacturers, decision makers and end-users along the gas value chain to enable mitigation strategies for retrofit THyGA will provide an extensive understanding of previous projects or studies related to H2NG admixture utilization with domestic and commercial appliances. Through extensive testing programme, the project will establish the impact of hydrogen concentration in natural gas on safety and performances of a large set of domestic and commercial appliances. Hence, THyGA will support recommendations for revising EN or ISO standards or drafting new standards and will fully support and secure FCH-JU’s “Hydrogen Roadmap Europe” (2019). THyGA project gathers 9 renowned partners including 4 research centres, 3 industries, 1 SME, and 1 association covering the whole value chain of natural gas. The extensive advisory panel includes manufacturers, European and International Associations and DSOs included in H2/NG blends projects ensuring a constant challenge of the processed results and a great opportunity for a wide dissemination/communication plan to share results.

Keywords: hydrogen,admixture,gas application,test,protocol,certification
Characterizing drivers of intestinal tissue maturation in vitro and in vivo (fetISC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-05-16
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

One of the challenges in regenerative medicine is to generate adult intestinal stem cells (ISCs) from human induced pluripotent stem cells (hiPSC) in vitro in defined conditions. This will be important in order to establish intestinal cell transplantation therapies and a platform for neonatal disease modelling. These issues constitute the main goal of the proposal. The current protocols to direct intestinal differentiation from hiPSC impede their suitability for human transplantation purposes either because they require mice as tissue culture incubators (teratoma formation), long exposure to calf serum, or generate cells with fetal properties. The immature fetal intestine is distinct from its mature counterpart most notably by its absence of differentiated secretory lineages. Moreover the precise location and developmental stage from which ISCs are specified in fetal intestine as well as the mechanisms that govern the progression towards an adult epithelium remain to be elucidated. In order to generate adult ISCs from pluripotent sources it is instrumental to decipher the molecular mechanisms driving ISC maturation under physiological conditions. The project will be initiated with the fine mapping of ISC origin in the fetal epithelium using cell tracing techniques. Then I will characterize how fetal ISCs acquire adult properties at the molecular level. In the host laboratory we hypothesize that differentially expressed transcription factors are responsible for the unique characteristics of fetal and adult ISCs. Recently, using gene expression profiling comparing fetal and adult intestinal cells I have identified specific endodermal transcription factors overexpressed in the immature structures. I expect through the modulation of such factors to trigger the intestinal maturation. To ensure the transferability of the results into clinics I will combine studies with murine models and cells from human fetal and adult intestines.

Keywords: tissue maturation,fetal intestine,intestinal stem cells,intestinal cell transplantation
Computer-assisted Analysis and Applications of Moving Interfaces in Incompressible Flows (CAMINFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The CAMINFLOW project aims to further explore the question of global regularity versus finite-time singularity formation in mathematical fluid mechanics. It proposes three horizons: 1) Modulated self-similar finite-time singularities in degenerate parabolic equations, 2) Fluid-interface finite-time singularities, 3) Rigorous analysis of fluid-structure moving interfaces. Module 1 is organized in two Work Packages: 1.1) Finite-time self-similar pinchoff for the axisymmetric surface diffusion equation (local, 1d), 1.2) Self-similar finite-time singularity in incompressible porous medium (nonlocal, 2d). Module 2 focuses on the blowup of the curvature of the Muskat problem (also known as Hele-Shaw). Module 3 contains two Work Packages: 3.1) Local and global well-posedness theory for the inextensible membrane problem. 3.2) Rigorous proof of the tumbling/tank-treading transition for inextensible membranes in a shear flow. A central and unifying method in this action is Computer-Assisted Proofs (CAP). Due to the highly demanding technical level of the analysis involved, new interval arithmetic libraries for singular integrals will be developed in Arb. Moreover, new modules in the framework Dedalus will be developed as well to perform accurate numerical simulations (that will help deciding whether a singularity is forming or not). These techniques will be applied complementing the methods from contour dynamics, harmonic analysis, and energy methods, needed to obtain results in the mathematical analysis of fluid interface problems. The CAMINFLOW project will be carried out by the experienced researcher, who worked during his PhD thesis on the global regularity question for incompressible fluid interfaces coming from nonlinear, nonlocal parabolic partial differential equations, and then as a postdoc moved on to fluid-structure elastic interfaces. The ER will collaborate with a Supervisor who is a prominent expert in CAP and their application to the fluid mechanics.

Keywords: finite time singularities,computer assisted proofs,muskat problem,global regularity,peskin problem,fluid interfaces,inextensible membrane
Pharmacological therapy to curtail visual loss in ADOA mouse model (PHERADOA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-12
End date: 2023-11-11
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

Autosomal dominant optic atrophy (ADOA) is the most common hereditary neuropathy that affects 1:35.000 people worldwide. A progressive visual loss is a characteristic of ADOA, and a treatment is not available. Mutations in the nuclear gene Optic Atrophy 1 (OPA1) in ADOA patients promote low levels of OPA1 protein, causing Retinal Ganglion Cells (RGCs) degeneration leading to blindness. OPA1 is the key component for mitochondrial inner membrane fusion mechanism and controls cristae biogenesis and remodeling, affecting cytochrome c release and apoptosis. So, mutations in OPA1 in RGCs may affect mitochondria integrity and lead to insufficient energy supply in the optic nerve. The role of OPA1 in ADOA-RGCs remains elusive since ADOA mouse models show inconclusive and no RGCs specific results. To address this issue, Dr. Luca Scorrano developed an ADOA mouse model of conditional RGCs OPA1 depleted. In this model, RGCs show fragmented mitochondria and excluded from axon but combined with autophagosomes in the axonal hillock. But a genetic autophagy inhibition restores mitochondrial distribution in the RGCs axon and curtails visual loss in the ADOA animal. These data suggest that autophagosome accumulation reduced axonal mitochondria content in RGCs by an impairment of the mitochondrial traffic. Therefore, we propose that visual loss of ADOA mouse model will be prevented by restoring its axonal mitochondrial content through a local use of inhibitors of the autophagy process. This proposal aims to develop a pharmacological therapy to curtail ADOA mouse visual loss. For this, we will deliver autophagy inhibitors through vitreal nanocarriers implants in ADOA mouse model which is conditional RGCs-OPA1 depleted. This research will contribute to provide a pre-clinical approach for a potential pharmacological therapy to ADOA patients.

Keywords: adoa,opa1,autophagy
“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics (Click-It)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Netherlands,Denmark,Denmark
Call: Development of new diagnostic tools and technologies: in vivo medical imaging technologies (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 5999800.0
EU funding (EUR): 5999800.0
Participants: 6
Project status: CLOSED

Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isotopes to be compatible with the slow pharmacokinetics of these large molecules. Major drawbacks are high radiation doses, precluding routine and repeated companion imaging procedures. The Click-It consortium aims to circumvent this issue by using pretargeting approach, which centers on the administration and target binding of a tagged nanomedicine followed by administration and binding of a small, fast-clearing, short-lived radiolabeled probe to the tag of the nanomedicine. This results in lower absorbed radiation doses and in a boost in target-blood ratios, which in turn leads to a superior imaging contrast. PET scan snapshots at multiple time-points provide long-term imaging information by applying short-lived nuclides. So far, only the fastest click reaction, the tetrazine ligation, has demonstrated potential in clinically relevant conditions. Recently, we have shown in a SPECT imaging study that this click reaction can be applied for non-internalizing nanomedicines in vivo. This project aims at expanding the scope of click-pretargeted imaging to intracellular targets, because a majority of nanomedicines internalize and is thus not accessible with the current approach. Furthermore, we will expand our approach to short-lived, non-metal based, small molecule 18F-PET tracers, since PET offers a higher spatial and temporal resolution enabling quantitative decision making in disease diagnosis and management. Finally, the project aims to translate the developed click-pretargeting technology into a clinically applicable nanomedicine-based imaging approach in relevant patient-derived xenograft (PDX) mouse models.

Keywords: click reactions,bioorthogonal chemistry,companion diagnostics,tetrazine ligation,pretargeted imaging
Advanced Technology for Microbial Electro-Synthesis of Platform cHemicals and Efficient in-situ Recovery via Electrodialysis (ATMESPHERE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-05-29
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Reduction of carbon emission to the atmosphere has become a key target to preserve the planet from its dramatic effects. The EU aims to become the first climate-neutral bloc by 2050, but development of novel carbon capture technologies, and a shift towards sustainable production of chemicals, are required to reach such ambitious goal. Microbial electrosynthesis (MES), in which CO2 is biologically converted to carboxylates and/or alcohols, enables reduction of carbon emissions whilst producing green chemical products. To date, acetate is the main compound produced from CO2 via MES, whereas more valuable caproate has been only produced at low concentrations due to product toxicity and thermodynamic limitations. The “atMESphere” project aims to push MES towards commercialisation by implementing a novel, resilient and sustainable biorefinery concept for selective production, extraction and concentration of caproate from CO2. In a first stage, the operation conditions in MES cells (including microbial consortia, pH, H2 partial pressure, and carbon availability) will be investigated and fine-tuned to obtain, for the first time, selective, high-rate caproate production from CO2. Then, a novel two-stage purification process, comprising of extraction through silicone membrane and concentration by shock electrodialysis, will be developed and integrated to the optimised MES cell, through a recirculation loop, to achieve selective separation of caproate, which has several applications in the energy, food and chemical industry. This project is highly interdisciplinary, involving tools, approaches and expertise from engineering, microbiology, electrochemistry, biotechnology, and membrane technology, and the experienced researcher will receive high-quality training on both scientific and horizontal skills. Dissemination, communication and exploitation activities have been planned to reach the most diverse audiences, and ensure commercial relevance of the proposed technology.

Keywords: microbial electrochemical technologies,bioelectrochemical systems,caproic acid,membrane extraction,shock,electrodialysis,hydrogen partial pressure,biocathode,greenhouse gas