Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Translational quantitative systems toxicology to improve the understanding of the safety of medicines - Sofia: 116030 (TransQST)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Belgium,Finland,Sweden,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Development of Quantitative System Toxicology (QST) approaches to improve the understanding of the safety of new medicines (H2020-JTI-IMI2-2015-06-two-stage, 2015)
Start date: 2017-01-01
End date: 2022-08-31
Duration (months): 68.0
Total project cost (EUR): 18132874.0
EU funding (EUR): 8000000.0
Participants: 25
Project status: CLOSED

TransQST will develop a Quantitative Systems Toxicology (QST) approach, employing pre-existing data where possible, in order to yield new mechanistic insight into drug-induced toxicity. A central tenet of our programme will be to ensure the human physiological and pharmacological relevance of any test system that has been (or will be) used for generating the input data for modelling. By adopting this approach, we will be able to accurately interpret what happens when test systems are perturbed by drug exposure, and ensure translatability of modelling tools. Mechanistic translational biomarkers are a core aspect of our approach and will be applied in parallel with evidence for understanding how to develop, model and apply such biomarkers in a QST setting. The project is structured in 8 work packages to provide the following outcomes: curate the best available experimental data suitable for modelling adverse drug reactions; provide fit-for-purpose QST models that will address key toxicity measures for liver, kidney, heart and GI-tract; provide quantitative risk assessment for off-target toxicity in man based on in vitro and in vivo models; provide a quantitative mechanistic read-across from species (in vivo and in vitro) currently used for the toxicological evaluation of a new drug; provide definition and applicability of the human physiological relevance of preclinical test systems; provide a battery of translational biomarkers that can be used for quantitative read-across from in vitro systems to man and which relate to intracellular pathways (and systems) relevant to drug toxicity. Led by the University of Liverpool, TransQST brings together 14 partners, characterized by their scientific rigour and proven track record. Collectively they will enable achievement of the goals of the call, thanks to their complementarity, proven ability to work together (and with EFPIA partners), and their understanding of how to ensure the relevance of QST to human biology.

Keywords: quantitative systems pharmacology,systems biology,pbpk modelling,translational safety,drug development
Mechanism Design under Incomplete Information (MEDINI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

The purpose of this project is to study mechanism design under incomplete information with an emphasis on the design of voting procedures. Mechanism design is the commonly used term for the design of games with a certain objective. For instance, an auctioneer may wish to design an auction with the purpose of maximizing his own revenue. The usual assumption is that the mechanism designer does not know the preferences of the players, but the players do have this information. In this project, the latter assumption is dropped. For instance, in national elections voters have a tendency to vote strategically, and in general only have limited information about the preferences of the other voters. In that case, the objective of mechanism designer (designer of the voting system) is to elicit as much as possible the true votes (preferences), knowing that the voters have beliefs but no complete information about the preferences of the other voters. Specifically, the project will concentrate on three issues: how does correlation between the voters’ beliefs effect the result of voting and how should the voting system be designed in order to elicit the true votes under this assumption of correlation; can we improve on the results of the first issue by allowing for probabilistic mechanisms, i.e., involve chance; and, following up on this, if truthful voting is out of reach, can we at least get the truthful voting result as an equilibrium outcome. The project is theoretical in nature but can lead to the design of experiments in particular testing the role of belief formation in voting. Further, the results of the project may lead to the design of improved smaller and larger scale voting procedures.

Keywords: mechanism design,incomplete information,voting procedures
Deciphering the dialogue between intestinal macrophages and their tissular niches (DIALOG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 2
Project status: SIGNED

Besides their role as immune sentinels, macrophages fulfil specific functions that are strictly related to their tissue of residence. As an example, the loss of gut macrophages is correlated with impaired crypt cells differentiation which might favour the establishment of chronic intestinal inflammation. Macrophage functions are known to be regulated by tissular niches that imprint the macrophage tissue-specific identity. However, little is known about the “feedback” role of the macrophage for the maintenance and function of its niche. I hypothesise that the loss of a given macrophage subset might imperil its microenvironment through the alteration of its niche cells function or maintenance. Unravelling this feedback mechanism is technically challenging. Current mouse models target macrophages themselves, inducing their rapid replacement by circulating monocytes and thus preventing their long term depletion. Here, I will take advantage of their dependence to a continuous provision of trophic factors by their niche to manipulate and study gut macrophages in a novel manner. First, I will unravel the composition of each gut macrophage niches in a global and unbiased approach by combining single cells and spatial transcriptomics. Next, I will determine the potential cellular sources of trophic factors in each gut niches. Once identified, I will use specific mouse models to delete the trophic factor in the candidate cells to induce a long term depletion of a given macrophage subset. Finally, I will unravel the function of macrophages to their niche by analysing in silico the niche cells transcriptome after macrophage loss to highlight potential molecular interactions between the macrophage and the niche that would induce the survival or differentiation of niche cells. They would eventually be confirmed in vivo by using specific mouse models.

Keywords: macrophage,niche,stroma,intestine
TOXicity assessment on neurons and cardiomyocytes by means of FluoRescence Emitting Electrodes (TOX-Free)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Germany,Italy
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-06-01
End date: 2024-11-30
Duration (months): 42.0
Total project cost (EUR): 3035166.25
EU funding (EUR): 3035166.25
Participants: 5
Project status: SIGNED

Pre- and post-marketing data on drug side effects show that neurotoxicity and cardiotoxicity are frequently missed or underestimated during pre-clinical testing. Neuro- and cardiotoxicity caused by pollutants including pesticides and industrial chemicals are equally difficult to assess. This results in suffering of individuals and in a considerable burden to society. One of the main reasons is that currently available testing approaches have several shortcomings, including sensitivity, human-relevance and suitability for non-invasive long-term recording. This project will develop a revolutionary and fully non-invasive technology to record in-vitro electrical signals from human neuronal and cardiac cells. High spatial resolution, combined with parallel recording of electrical signal coordination and propagation among thousands of neurons or cardiomyocytes, will allow the assessment and quantification of subtle disturbances by toxicants from the drug, pesticides and industrial chemicals sectors. The full non-invasiveness will enable, for the first time, the long-term functional in-vitro monitoring of biologically relevant cellular models, paving the way toward the reliable assessment of chronic toxicities. The novel biosensing technique (VICE) will emerge from the efforts of nanotechnology developers in close collaboration with toxicologists and specialists in surface functionalization and electrophysiological data acquisition. With its joint expertise, the consortium will continuously refine the VICE biosensor with innovative functionalities while thoroughly testing it in toxicology and pharmacologicy experiments. This will not only lead to a revolutionary approach to monitor functions of heart and brain cells, but also ensure the direct applicability to relevant questions in safety sciences and pharmacology. Ultimately, the project will elicit the future development of a whole new class of biosensors based on the groundbreaking concept of VICE.

Keywords: in vitro toxicology,electrophysiology,neurons,cardiomyocytes,heart,brain,drug safety,toxicants,pollutants,neurotoxicity,chronic cardiotoxicity
Relocating Modernism: Global Metropolises, Modern Art and Exile (METROMOD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1928400.0
EU funding (EUR): 1928400.0
Participants: 1
Project status: SIGNED

Breaking new ground, METROMOD proposes a rewriting of modern art history as a history of global interconnections, spurred by migration movements and rooted in cities. Revising the historiography of modern art, which still continues to be dominated by the hegemonic and normative narratives of (Western) European Modernism and ignores the significance of exile movements, METROMOD conceptualizes art history as a result of interrelations and negotiations in global contact zones, unstable flows, transformations and crises. In its analysis, METROMOD focuses on the first half of the 20th century. During this era the modern movement emerged as a paradigm in art and architecture, and rapid urbanization took place globally; thousands of persecuted European modern artists fled their homes, re-establishing their practices in metropolises across the world. Reflecting both the geographical extent of these exile movements and their local urban impact METROMOD examines 6 key migrant destinations—the global cities of London, New York, Buenos Aires, Istanbul, Shanghai and Bombay (now Mumbai)—following three main objectives: to explore transformations in urban topographies, identifying artistic contact zones and places of transcultural art production; to investigate networks of exiled and local artists as well as collaborative projects and exhibitions; and to analyse art publications and discourse generated in centres of exile. Digital mapping will locate sites of artistic migration in the cities and demonstrate linkages between transforming metropolises and flows of people and objects around the world. The conceptual triangle of modernism, migration and the metropolis forms the foundation of an innovative comparative, interdisciplinary methodology. As well as impacting art history, METROMOD will provide a historical perspective from which today’s mass migration movements can be better understood.

Keywords: migration and exile history,cultural transfer,urban studies,history of modernism,transfer of ideas and knowledge,historiography,20th century,jewish studies
World Gaming Federation: The future of Video Games comes from Europe (Video Games Europe)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2016-01-01
End date: 2016-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

World Gaming Federation intends to solve major issues in the videogames market by providing a worldwide platform including all ecosystem actors: players & teams, publishers, event organizers, brands & sponsors. The videogames market is facing important growth challenges (2Bn players in 2018) with the exponential growth of mobile gaming, online gaming (including free games) and competitive gaming (Esport). All actors, from players to publishers, as well as brands and sponsors want to increase their profitability by making more revenues and embrace new income sources. Today, they have no serious way to analyze return on investment and do not have access to all the data, and the ability to answer these opportunities as globalization adds complex market interactions. The objective of World Gaming Federation’s platform is to help the industry to monetize and ease their relations with users thanks to our end-to-end advanced features based on big data. We will provide a videogames database with more than 47,000 games referenced, linked to a powerful tournament software to produce a unique worldwide ranking. We will provide a 100% videogames players database to help publishers target the best community for their marketing campaigns and bring new revenues through brands’ sponsoring. This will represent a major innovation, as there is today no worldwide platform gathering all data, player’s profiles and a global ranking system. WGF is a high risk innovative SME willing to develop a unique innovative platform, which will help all stakeholders to address opportunities and disrupt the existing markets. The feasibility study is a mandatory step to validate the proof of concept, including technical and commercial viability, design study and first pilot website. We will then develop the platform and speed our time to market.

Keywords: video games big data web platform unified rankings communities publishers event organisers,sponsoring return on investment on marketing campaings
Exploring the outer solar system beyond Neptune using stellar occultations (LUCKY STAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2021-10-31
Duration (months): 72.0
Total project cost (EUR): 2423750.0
EU funding (EUR): 650000.0
Participants: 3
Project status: CLOSED

The solar system beyond Neptune’s contains largely unaltered material from the primordial circum-solar disk. It also kept the memory of the early planetary migrations, and thus contains essential information on the origin and evolution of our planetary system. Here I propose to study the Trans-Neptunian Objects (TNOs) using the stellar occultation technique. It consists in observing the passage of remote TNOs in front of those “Lucky Stars”, that reveal shapes, atmosphere and rings of bodies from sub-km to thousand-km in size. Very few teams in the world master this method. The European-led network that I coordinate is now leader in predictions, instrumentation, observations and analysis related to stellar occultations, with innovative approaches and unprecedented results. In the last decade, our group led the field by discovering rings around the asteroid-like object Chariklo, detecting sub-km TNOs and drastic variations of Pluto’s atmospheric pressure. Based on those noteworthy discoveries and unique skills of ours, I will coordinate the following work packages: (1) Rings around small bodies - Understand the newly found Chariklo’s rings, tackle the theory of rings’ origins and evolutions around small bodies, discover new ring systems around other bodies. (2) Very small, sub-km TNOs and Oort Cloud objects - Constrain the collisional history of our early outer solar system, and possibly detect Oort Cloud objects. (3) Pluto’s atmosphere – Explore Pluto’s atmosphere and its atypical seasonal cycle, search for atmospheres around other TNOs. (4) Explore specific, large TNOs – Provide their sizes, shapes, albedos and densities. These programs are timely in view of NASA/New Horizons Pluto flyby in July 2015, and the ESA/GAIA mission expected to provide a greatly improved astrometric catalog release in 2016. Most of the budget will be dedicated to human power to conduct observations and their analysis, plus the associated travel and telescope time expenses.

Keywords: pluto,rings,trans neptunian objects,oort cloud
Impact of exposome on the course of lung diseases (REMEDIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Norway,Belgium,Greece,Switzerland,Hungary,France,France,France,Denmark,United Kingdom
Call: The Human Exposome Project: a toolbox for assessing and addressing the impact of environment on health (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 11013022.14
EU funding (EUR): 11013022.14
Participants: 18
Project status: SIGNED

Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are two very debilitating non-communicable diseases that are of particular interest to consider in parallel in a human exposome study. Their roots are opposite: COPD is currently considered to be mainly related to the external exposome, while factors outside of the exposome play a major role in CF. However, COPD and CF share common characteristics such as high phenotypic variability of unknown origin, which prevents good therapeutic efficacy. It is therefore clear that the overall picture must be supplemented by taking into account additional components of the exposome than those currently considered in COPD and CF. Thus, the overall objective of the REMEDIA project is to extend the understanding of the contribution of the exposome, taken as a complex set of different components, to COPD and CF diseases. We will exploit data from existing cohorts and population registries in order to create a unified global database gathering phenotype and exposome information; we will develop a flexible individual sensor device combining environmental and biomarker toolkits; and use a versatile atmospheric simulation chamber to simulate the health effects of complex exposomes. We will use machine learning supervised analyses and causal inference models to identify relevant risk factors; and econometric and cost-effectiveness models to assess the costs, performance and cost-effectiveness of a selection of prevention strategies. The results will be used to develop guidelines to better predict disease risks and constitute the elements of the REMEDIA toolbox (global unified database, sensor device, versatile atmospheric simulation chamber, machine learning supervised analyses, causal inference model, Pan-European multi-criteria risk assessment tool, econometric models, cost-effectiveness models, new guidelines and recommendations). Deciphering the impact of environmental components throughout life on the phenotypic variability of COPD and CF could represent a major breakthrough in reducing morbidity and mortality associated with these two non-curable diseases and would lead to the identification of modifiable risk factors on which preventive action could be implemented. REMEDIA will be part of the European Human Exposome Network established between the 9 projects funded within the Human Exposome programme call H2020-SC1-BHC-2018-2020.

Keywords: lung diseases,exposomes,retrospective epidemiological studies