Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Service Platform to Host and SharE REsidential data (SPHERE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Innovation actions
Countries involved: Ireland,Austria,Germany,Spain,Spain,Germany,Ireland,Italy,Italy,Belgium,Finland,Türkiye,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: ICT enabled, sustainable and affordable residential building construction, design to end of life (IA 50%) (H2020-NMBP-EEB-2018, 2018)
Start date: 2018-11-01
End date: 2022-10-31
Duration (months): 48.0
Total project cost (EUR): 12540256.21
EU funding (EUR): 7423038.76
Participants: 32
Project status: CLOSED

SPHERE’s ultimate goal is the Improvement and optimisation of buildings’ energy design, construction, performance, and management, reducing construction costs and their environmental impact while increasing overall energy performance. SPHERE project will integrate two planes of research, innovation and improvement: • integration of the processes under the Digital Twin Concept involving not only the Design and Construction of the Building but including also the Manufacturing and the Operational phases • integrated platform that will be achieved through an underlying ICT Systems of Systems infrastructure based on Platform as a Service (PaaS) service to allow large scale data, information and knowledge integration and synchronization thus allowing a better handling and processing e.g BIMBots, machine learning , simulation etc. This Digital Twin concept is in fact a distributed but coordinated Database, including geometrical objects information that forms a unique synchronized virtual model of the reality. As has been proven in other fields, twinning this virtual information model with the reality helps significantly in decision-making during each phase of the whole building’s lifespan (manufacturing, design, construction, maintenance, operation, retrofitting and even demolition). The SPHERE cloud-ICT platform will allow to interact all different stakeholders during any phase of the asset with a building Digital Twin model of information of the building and a scalable set of different software tools, such as energy demand/performance simulation tools, Decision Support and Coaching Systems, BEMs or IoT enabled Predictive Maintenance Algorithms. The Digital Twin Concept, platform and Tools will be tested in four real pilots and finally validateted both technically and especially final social acceptance to accelerate market uptake.

Keywords: digital twin,design,maintenance,retrofitting,decision making,virtual model,construction,manufacturing,operation,systems,interoperability,semantic data,platform,social acceptance
Assessment of cardiac function by new ultrasound imaging strategies: towards a reliable clinical routine (ACOUSTIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2019-11-30
Duration (months): 19.0
Total project cost (EUR): 127300.0
EU funding (EUR): 127300.0
Participants: 1
Project status: CLOSED

Cardiovascular diseases remain the leading cause of death in the world and has a tremendous impact on our society. Since major diseases are associated with dysfunction of the left ventricle, the accurate assessment of ventricular function during all phases of the heart cycle is fundamental. This goal may be facilitated by ultrasound imaging, which is in general appreciated for its bedside applicability, good temporal resolution, real-time operation, low cost and absence of ionizing radiation. The overall objective of this project is to improve cardiac ultrasound diagnostics by developing an innovative system for imaging at very high temporal and spatial resolution. This will be achieved through innovative developments in: ultrasound image formation, ultrasound signal processing, and real-time applications. Each of them will be first simulated, then experimented in-vitro, and finally tested in-vivo on human subjects. These developments will add diagnostic and prognostic information to the cardiac ultrasound examination and will enable clinicians to better study cardiac blood-wall interactions. The objectives are in line with those of H2020 EU: improving the “life-long health and well-being of all while maintaining economically sustainable care systems”; and “boosting Europe's industrial leadership through research, technological development, demonstration and innovation”. The project will also pursue the experienced researcher’s professional maturity so as to improve his career. In fact, the training and research program is highly multidisciplinary and integrates leading expertise in the fields of ultrasound and electronic engineering, signal/image processing and clinical cardiology provided by host and secondment institutions. At the same time, the researcher will share his system-oriented knowledge with the host institution to build a background in advanced US technology.

Keywords: ultrasound,high frame rate,cardiac,real time,clinical,strain,blood flow,ventricle,development,validation,innovative
Artificial Compartment for Coenzyme Regeneration (ARC-for-CORE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-18
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

This project is to build an artificial compartment for coenzyme regeneration, urgently demanded by industry and scientific research to enhance the stoichiometric use of coenzyme in biosynthetic pathways. The fellow will investigate all-round aspects of the bio-inspired system, including compartmentalization process, mass transfer and biological reactivity. A new mechanism for selective bidirectional transport and structure-reinforced composite shell will be proposed. Capitalizing upon his expertise in biomimetic controlled delivery system, carbon nanomaterial, emulsion and scanning electrochemistry, the fellowship makes him a unique asset to EU for the brand-new exploration of bio-inspired selective transport system and coenzyme regeneration compartment. The fellow has proven track record with multi- and interdisciplinary background and his achievement has been outstanding as demonstrated in CV. The skills he will gain allow him to diversify his capability significantly, including interfacial polymerization and molecular imprinting technique, visualized delivery dynamics, capsule manipulation and stability test, enzymatic integrity and activity test, compartmentalized enzymatic reaction, microfluidic multiple emulsification and techniques for SECM set-ups and analysis. The output will be the knowledge obtained from the formation of the artificial compartment through bulk and microfluidic interfacial polymerization, the compartmentalized enzymatic reactions and new set-ups for SECM. In addition, the fellowship will allow him to transfer his existing knowledge and the one emerged from the research to the hosts and a variety of audience, via complementary activities. The effective and reliable coenzyme regeneration system will address the challenge of coenzyme utilization in the biological industry. Fostered by the fellowship, a leading expert in biomimicry and coenzyme regeneration is expected to contribute greatly to EU industries and academic communities.

Keywords: interfacial polymerization,emulsion,molecular imprinting,molecular recognition,coenzyme regeneration,scanning electrochemical microscopy,compartmentalized reactions,biomimicry,microfluidics
A universe of media assets and co-creation opportunities at your fingertips (MediaVerse)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Germany,Italy,Germany,Switzerland,Switzerland,Belgium,Greece,Greece,Portugal
Call: Next Generation Media (H2020-ICT-2020-1, 2020)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 5995612.5
EU funding (EUR): 4932997.5
Participants: 12
Project status: SIGNED

The traditional media landscape is in the middle of a monumental shift: boundaries between professional media houses, prosumers and small creators are blurring, the speed of communication and publishing is increasing, audiences are seeking more user-driven and accessible multimedia experiences. MediaVerse (MV) is an answer to this shift: a decentralized network for intelligent, automated, and accessible digital asset management systems, where traditional stakeholders and other media owners can share, enrich, verify, and monetize multimedia content. With this, MV aspires to disrupt current practices of working in isolated silos, while enabling secure and traceable media exchange. An instance of MV can be deployed as a node in the decentralized MV network, and provides its users with a blockchain-enabled rights management solution, AI-powered identification services and smart contracts that automate cross-network rights negotiation and content monetization. Following the European way, MV aspires to help users create and publish content, while keeping control over the content shared. For this, several AI-driven features are implemented towards supporting automated editorial content moderation and identification, authoring immersive experiences, making content accessible, and providing actionable insights through social analytics and collaboration tools. Integrated content adaptation services ensure the distribution of the created media over several networks, platforms and end-devices. The project will be validated through large scale pilots in the field of citizen journalism and co-creation of immersive and inclusive media, foreseeing also a STARTS-inspired use case that involves artistic experiments and practices, pushing forward creativity for a critical approach to user-centric media.

Keywords: digital asset management,media rights,immersive media,vr content,360 content,content moderation,media annotation,social media analytics,xr authoring,media discovery,blockchain,accessibility
Optical control of CaMKII signaling (OCOCAMKS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2021-06-01
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

How are memories formed and stored in the brain? One candidate mechanism is long term potentiation (LTP), a form of synaptic plasticity that is characterized by strengthening of synaptic connections between neurons in the brain, lasting from minutes to hours. The first step in LTP is a sharp influx of calcium ions, which serves to activate many Ca2+-dependent proteins, one of which is Calcium-calmodulin-dependent protein kinase II (CaMKII). Once activated, CaMKII translocates to the post-synapse, and phosphorylates numerous substrate responsible for LTP induction. Curiously, CaMKII also has a role in specifying cellular structure by bundling actin. After activation, CaMKII activity apparently becomes Ca2+-independent, and can last for hours after the initial stimulation. This property of CaMKII lead the researchers to propose that CaMKII, in addition to induction of LTP, could also be responsible for LTP maintenance and hence memory storage. I propose to study the role of CaMKII in both the induction and maintenance of LTP in neurons. For this purpose, I plan to generate variants of CaMKII that can be acutely controlled by light. Using the tools I develop, I will investigate the interplay between CaMKII function and structure with respect to LTP and other neuronal processes. This approach offers unprecedented molecular, spatial and temporal control over CaMKII activity in neurons, allowing a better understanding of its involvement in learning and memory.

Keywords: camkii,long term potentiation,unnatural amino acids,kinase signaling,holoenzyme
Bringing unlimited autonomy to Civilian Drones : PULSE, an Intelligent Tethered Power Supply. (Elistair)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Drone operators are suffering from a major weakness of this technology : autonomy. The average time of flight is around 15 minutes, which reduces considerably the productivity and the potential applications of unmanned aerial vehicles. Our company Elistair brings unlimited autonomy to civilian drones. We design and manufacture tethered power supply for drones. Our project is to develop the first intelligent tethered power supply system for civilian drones : compatible with 95% of civilians multicopter drones, it will bring unlimited power from the ground station to drones through a extremely lightweight micro-tether. This tether will also include secured and unjammable high speed data transfer. The data will be displayed and processed in real-time thanks to a computer at the ground station. Thanks to this tether, the drone is not considered as a drone by civil aviation laws (secured operations). We target three applications : structural inspections, aerial surveillance (response forces, firemen etc...), aerial broadcasting for live events, and telecommunications. The objectives of our innovation project are : • to assess the commercial and technical feasibility for our tethered system PULSE. • to define the utmost performing solution and new technical design of the tether power supply system, with the inclusion of the data transfer function. • to lead an intellectual property study in order to define an IP strategy. This will help us to address foreign markets. • to rapidly prototype the final system. Our company is located in Lyon and we are a team of five (mostly engineers). We are currently prototyping and are working with industrial beta testers (Thalès, Bouygues Energie et Services, Euronews, Red Bird...). Our first prototype is focused on the power transmission.

Keywords: drone,tethered drone,autonomy
Evolution of the thermal plasticity of gene expression: a reverse evolution experiment using Drosophila simulans. (ReversePlasticity)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Phenotypic plasticity, the ability of a genotype to express distinct phenotypes in different environments, is assumed to facilitate individuals coping with new or rapidly changing environments. In the context of climate change, the phenotypic response to temperature has received particular attention since thermal plasticity is affecting the survival of populations and species distribution. Although temperature is an important variable that affects many traits, including gene expression, the genetic basis of phenotypic plasticity evolution remains poorly explored. This project aims at understanding what determines thermal reaction norms, i.e. how gene expression changes with temperature. Preliminary work in the host laboratory suggests that these reaction norms are modified during adaptation of Drosophila melanogaster populations evolving in a new fluctuating thermal environment. Yet, it is unclear whether these changes are the result of selection on phenotypic plasticity or if they are driven by direct selection on the trait value in the novel environments, as both effects are confounded. To detect adaptive change in phenotypic plasticity, we will use a reverse evolution experiment in which D. simulans populations first evolved in one of two different fluctuating thermal environments (hot and cold) and after one year were shifted to the other environment. We will analyse the gene expression profile of these populations at three successive time points during their evolution over a wide range of temperatures (from 15°C to 27°C). By changing the environment in the opposite direction, we will be able to distinguish between selection on plasticity and selection on the trait value, since the latter will not revert plasticity towards the initial state. Hence, we will distinguish adaptive and non-adaptive components of thermal plasticity of gene expression, and identify genetic pathways under selection for phenotypic plasticity.

Keywords: experimental evolution,phenotypic plasticity,reaction norms,transcriptomics
Technological change at the South-western limits of the Mediterranean basin during Neolithic and early Chalcolithic times: pottery production and consumption (NEOMEDPOT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project examines the radical social changes which took place in the South-western Mediterranean basin during the Neolithic and the beginning of the Chalcolithic period, and specifically the interactions between North Africa and the southern coast of the Iberian Peninsula across the Straits of Gibraltar. It takes an explicit technological approach informed by Material Culture Studies which uses the reconstruction of the craft of pottery manufacture to inform our understanding of social transformation.It comprises the first research programme focused in pottery analysis across a wide area of study, including North African and European production, the first of which remains mostly unknown until now. The methodology employed is an integrated approach based on instrumental analysis of pots (optical petrography and SEM), including morphological, ornamental and functional characterization of ceramic products; as well as the comparison of ceramic fabrics with potential raw materials in the study areas. A number of key archaeological questions are addressed in this way. The time period considered sees changes in food production, along with increased sedentism and specialization in craft production of ornaments. While Neolithic cultures have often been defined according to their pottery and their stylistic groups, it is the technological traditions associated to them will allow us to explore mechanisms of knowledge transmission and innovation, labour organization and the construction of exchange networks. These are all key aspects which allow us to explore the links between technological change and the social change in the human communities in the area in study, at a time when semi-nomadic groups adapt to sedentary ways of life with the emergence of social asymmetry and labour specialization in the early Chalcolithic.

Keywords: material culture,pottery,neolithic,chalcolithic,iberia,morocco,archaeometry,technological choices,provenance analysis
Mass spectrometric technology for next generation proteomics in systems medicine (MSmed)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Netherlands,Denmark
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 5038875.0
EU funding (EUR): 3672625.0
Participants: 4
Project status: CLOSED

Systems medicine designates the application of global approaches to human health and disease. Genomic technologies, especially next-generation sequencing, are already pioneering this new area. There is an urgent need to advance proteomics technologies to a similar level. This will help revolu¬tionize diagnosis and prognosis based on the expression levels and modifications of proteins in cells, tissues, organoids or body fluids. Our vision is to make mass spectrometry so robust and powerful that it will be present in every biological laboratory and in every clinic. The applicants are leaders in proteomics technologies from academia and industry and have an out-standing track-record in advancing both instrumentation as well as its application in biological and disease contexts. Here we come together to develop breakthrough technology capable of more than a factor ten improvement in parameters of performance of the mass spectrometric workflow, ena¬bling patient-oriented proteome profiling. The proteomics workflow will be automated, multiplexed and made ‘industrial strength’ - ready for high-throughput and in-depth clinical applications. Importantly, in addition to the identification of the main protein representative of a gene, we aim to routinely identify and quantify protein modifications and isoforms by using multidimensional approaches, including new separation, enrichment and frag¬mentation technologies. The breakthroughs aimed for will generate larger more biologically relevant data. This data will be merged with other ‘omic’ data and mined using machine learning technologies. Our results will establish the role mass spectrometry in systems medicine, making all workflows and mass spectrometry platforms available to the community. They will be used as the basis of myriad applications in biomedicine, even in the clinic. This in turn will lead to a new eco-system around improved diagnosis, elucidations of disease mechanisms and drug action.

Keywords: mass spectrometry,systems medicine