Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The behavioral, fMRI, and EEG profiles of multifocal attention (MUFOCA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-07-01
End date: 2016-06-30
Duration (months): 36.0
Total project cost (EUR): 268781.1
EU funding (EUR): 268781.1
Participants: 1
Project status: CLOSED

The proposed project will investigate how selective attention is implemented in the architecture of the visual system. Using both behavioral and cognitive neuroscience methods, we will study attentional tracking of multiple objects that move independently in the visual field. Previous research has shown that the capacity to select and monitor multiple objects and their locations varies as a function of visual field: twice as many objects can be selectively tracked when presented bilaterally (i.e., in both left and right hemifields) compared to when they are presented unilaterally (i.e., within a single hemifield). These behavioral findings imply considerable independence of the attentional resources for each visual field, thereby challenging the traditional view of attention as a central, monolithic resource. We hypothesize that attentional tracking of independently moving objects is subserved by hemifield-specific attentional foci that (i) alter the suppressive profile of attention independently for each hemifield, and that (ii) these attentional foci are implemented in a dynamic parietal network that changes configuration depending on how attention is allocated in the visual field. Several experiments will be conducted using scalp recorded steady-state visual evoked potentials (SSVEP), functional magnetic resonance imaging (fMRI), and behavioral responses in healthy adults with the goal of constructing a complete framework that explains attentional tracking and the mechanisms of multifocal attention. The project will significantly contribute to our understanding of basic attention and perception mechanisms and will also improve our understanding of human performance in many everyday situations that require us to pay attention to multiple items at the same time.

Keywords: s203 neuropsychology and cognitive psychology,s204 clinical and experimental psychology
Adaptive Responses to Climate Change (ARC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

The major challenge in climate-change ecology is to predict the impact of future climate change on populations. To provide the most realistic way to forecast the future of key species, we must consider simultaneously demographic (e.g. growth, rate of survival and reproduction), physiological/behavioural mechanisms (e.g. hormonal responses, thermal tolerances, huddling) and genetic vs phenotypic variation. However integrative mechanistic population models that incorporate these processes remain scarce. The ARC project meets this challenge and responds today to the need of a complete framework. It will provide a mechanistic view of the causes and consequences of populations’ responses to climate change to predict their distribution and implement accurate conservation strategies. My project presents a rare combination of data, skills and experience by combining a long-term (1990-2012) dataset and experimental explorations of the proximal mechanisms using the Alpine marmot (Marmota marmota) as a model species. Using a four-tier approach, I will (i) investigate environmental and social factors that influence phenotypic and phenological traits affecting population dynamic; (ii) determine the physiological mechanisms underlying the critical trait-demography relationships; (iii) identify the relative roles of evolutionary and ecological responses. Then, I will integrate demographic, physiological and evolutionary processes identified above to predict the change in this alpine species’ range and evaluate its vulnerability or resilience to current climate change. To elucidate the complexity of adaptive responses to climate change, it brings together complementary knowledge and methods from disparate disciplines. The multi-disciplinary approach and state-of-the-art methods proposed by the ARC project is a crucial step towards a more comprehensive and mechanistic understanding of the influence of climate change on population viability and, ultimately, on biodiversity.

Keywords: adaptive capacity,capture-mark-recapture,climate change,energy saving mechanisms,marmota marmota,mechanistic distribution model,physiology,population dynamics,trait-based demography
The roles of juvenile NMDA receptors in synapse maturation and elimination and their association with cognition (NMDAR-SYNPRUN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

The aim of the project is to understand how the NMDA receptor subunit NR3A is involved in selective synapse elimination (“pruning”) during development and how the abnormal expression of NR3A found in mental disorders such as Schizophrenia, Alzheimer´s disease and Huntington correlates with the reduction of functional synapses and deficits in the cognitive function. Importantly, the Host lab has already proved that restoring the normal NR3A expression levels reverses both, the spine lost and the cognitive impairment in mouse models. My working hypothesis is that NR3A and its associated signalling complexes act locally as a brake on the maturation of specific synapses to direct targeted, activity-dependent destabilisation and pruning. I will test this hypothesis by: 1) studying mechanisms that underlie the inhibitory effects of NR3A on synapse stabilization or its facilitation of pruning, 2) evaluating how genetic manipulation of NR3A signalling pathways affects cognition. Candidate inhibition/pruning mechanisms that will be tested here include destabilizing effects of NR3A in NMDA receptor mobility within the plasma membrane, altered NMDAR synaptic localization, and recruitment via intracellular domains of NR3A of signalling complexes driving synapse destabilization and disassembly. Specifically, I will use a combination of established and recently developed imaging, molecular biology, electrophysiology and behavioural techniques in primary neuronal cultures, brain slices and the whole animal. The proposed work not only will reveal the molecular links between NR3A expressions, neuronal connectivity and cognitive function in the normal brain, but also will provide and validate suitable targets for the therapeutic intervention in mental disorders where synaptic lost underlies deficits in cognition.
Regulation of alpha-v-beta-8 integrin expression and its role in intestinal immune homeostasis (ITGB8 REGULATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-10-01
End date: 2015-12-30
Duration (months): 24.0
Total project cost (EUR): 134487.3
EU funding (EUR): 134487.3
Participants: 1
Project status: CLOSED

Transforming growth factor-beta (TGF-b) plays a critical role in maintaining gut immune homeostasis. Although ubiquitously expressed, TGF-b must be activated in order to enable subsequent signaling. TGF-b activation thus represents a major point of regulation of intestinal immune responses. I have shown that expression of alpha-v-beta-8 integrin (avb8) by dendritic cells (DCs) is required to activate TGF-b so that it can signal to T cells. Furthermore, I have shown that avb8 expression is restricted to intestinal CD103+ DCs. However the mechanisms by which avb8 expression, and thus the ability to activate TGF-b, is restricted to this subset of DCs are unknown. In this fellowship, I propose (1) to define the mechanisms by which avb8 expression is regulated in DCs, and (2) to determine whether avb8 expression program can be manipulated in order to control intestinal inflammation. These studies will provide a detailed understanding of how DCs acquire a key immune-regulatory function, the activation of TGF-b. Furthermore, they will explore whether this is disrupted in patients with Inflammatory Bowel Diseases (IBD) and if avb8 expression can be manipulated in DCs. Together, this will provide new information on how intestinal homeostasis is established, and open new areas of research for the development of IBD treatment. The increase in IBD and the chronic and debilitating nature of these disorders emphasize the relevance of a better understanding of the processes that underlie normal regulation of mucosal immune responses. The implementation of this proposal will build on both the expertise of the Host Institution and the transfer of unique know how and tools by the Applicant from Harvard Medical School. This transfer includes both reagents and collaborations I developed during my postdoctoral experience. Thus this proposal will develop long-lasting cooperation between leading US-Research center and contribute to increasing European excellence and competitiveness.

Keywords: inflammatory bowel disease,mucosal immunity,alpha-v-beta-8 integrin,dendritic cell,gene expression regulation
LASER manipulation of PLASMONic nanostructures (LASER-PLASMON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The ability of metal nanostructures to manipulate light at the nanoscale has resulted in an emerging research area called plasmonics. Plasmonics has developed into a rapidly maturing and broad research field, and it is progressively becoming an enabling technology for a number of forefront research areas like photovoltaics, chemical and biological sensing, medical therapy, information technology etc. However the fabrication of plasmonic devices is technically challenged because: there has not been developed yet a technique for precise control over the plasmon features, there is an engineering difficulty of delivering sharp nano-sized interfaces between metal and dielectrics, there is up to now no compatibility with large scale plasmonic applications and finally an experimental systematic study misses currently from the literature, which in turn provides a lack of feedback to technology for successful plasmonic large-scale applications. This proposal aims to address the hurdles mentioned above, through a wise implementation of a process technique that can be easily adopted by industry. This technique is Laser Annealing (LA), which can be a promising innovation in the field of plasmonics. The objectives of the present proposal are: 1. To develop and optimize seed materials for plasmonic nanostructures, 2. To identify the most appropriate LA system design and LA processing parameters, 3. To investigate the underlying mechanisms that govern the alteration of the NPs and their surrounding environment’s structure and opto-electronic properties, 4. To deliver the currently missing link between materials, deposition techniques and LA process parameters, by means of an experimental library that would facilitate the future development of plasmonic applications.

Keywords: p109 lasers and laser physics,p212 nanophysics,p306 surface science,p321 surface physics
Old English Identity and the Final Stages of the Tudor Conquest of Ireland, 1599-1603 (OEIFTCI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-05-01
End date: 2016-04-30
Duration (months): 36.0
Total project cost (EUR): 229775.7
EU funding (EUR): 229775.7
Participants: 1
Project status: CLOSED

Ireland’s Nine Years’ War (1594-1603) marks a crucial juncture in the development of three unique cultural identities: Gaelic Irish, Old English, and New English. But, while this war reinforced the socio-religious character of the Gaelic Irish and New English, it compelled the descendants of Ireland’s twelfth-century Anglo-Norman conquerors, known collectively as the Old English, to reappraise their status as Irish-born Catholics loyal to the English Protestant establishment. Building upon my doctorate, which examined aspects of Old English identity formation within the Pale – an area roughly comprising counties Dublin, Kildare, Meath, Westmeath, and Louth – during the first stage of the Nine Years’ War (1594-1599), this project will consider the same community during the second stage of this conflict (1599-1603). This war is best studied in two phases because the April 1599 arrival of the Earl of Essex as Lord Lieutenant of Ireland coincided with a marked escalation in hostilities, an increased commitment of money and manpower from England, the resurrection of a militant Jesuit mission, and the deployment of an aggressive patriotic propaganda campaign by the Irish Catholic Confederacy. The impact of this intensification on the Old English Pale community would have been noticeable and this project will explore how escalating hostilities, clerical involvement, and the production of patriotic propaganda during the second phase of Ireland's Nine Years’ War contributed to the emergence of a distinct Old English identity by the early 1600s.

Keywords: social history,identity formation,economics,military,cultural history,minority politics,transnational history,transmission of ideas
Nanomaterial Photonic Sensors for Food Manufacturing (NPS4FM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2014-02-10
End date: 2016-02-09
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

The ultimate goal of the project is to generate and transfer knowledge on the development of new nanomaterials specifically applicable in novel macro-bacterial sensors for food manufacturing and processing industry. The special structure of nanomaterials gives rise to their amazing properties. The ability to manipulate the structure and composition on the nanoscale provides very large opportunities to create new materials with superior performance for new products and devices. Since the optical properties of nanomaterials can be controlled by changing their size, shape, and aspect ratio, as well as via their surface modification, nanomaterials are prime candidates as building blocks for photonic sensors. The overall objective of this research is to develop the synthesis of ZnO, ZnS and PbS nanostructures with different sizes and morphologies via the laser ablation in liquid technique, then to modify and functionalize the surfaces of the prepared nanostructures and finally to use them for the preparation of photonic sensors with bacteria-detecting properties. Such efficient, easy-to-use and rapid sensors will be evaluated within different food processing, weighing and packaging lines available from project partner. This is an ambitious research programme, with a strong interdisciplinary nature combining materials engineering, surface science, bio-engineering, physics, chemistry and soft matter science. Its success is underpinned by the combination of complementary expertise of the Fellow, Host and Partners in nanomaterial preparation and characterization, photonics and food processing and analysis, respectively. The project will have a positive impact on a longer shelf-life of ready food, monitoring of food manufacturing lines, and optimization of cleaning routine during food manufacturing and packaging. Hence, positive impact on public health sector, as well as economic and ecological effects, is expected.

Keywords: laser ablation in liquid,nanomaterials,photonic sensors,bacterial detection
The role of long intergenic non-coding RNA in intestina stem cells (LINCRNA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

Studies on long intergenic non-coding RNAs (lincRNAs) suggest an important role in development and cancer, however, functional lincRNAs in adult stem cells have been rarely defined. This project will study the role of lincRNAs in development of intestinal stem cell (ISC) one of the well identified adult stem cells. For this purpose, I will identify lincRNAs that are specifically expressed in ISCs by analyzing transcriptome of sorted ISCs. LincRNAs expected to regulate ISC development will be selected. I will investigate the mechanisms of action of the lincRNAs using in vitro cultured mini-gut. Lastly, I will elucidate the physiological function of the lincRNAs by generating knock-out mouse models. It has become evident that lincRNAs regulate multiple cellular functions including pluripotency, differentiation, and cell cycle. This project will, therefore, broaden our knowledge on adult stem cell biology revealing how lincRNAs play a role in self-renewal and differentiation of ISCs. At the same time, this project will extend our understanding of lincRNA biology by providing a comprehensive functional study in a physiologically relevant system. Furthermore, given that ISCs are highly linked with cancer stem cells, the defined lincRNAs might be used as diagnostic markers and therapeutic targets in cancer.

Keywords: l312 stem cell biology,l101 molecular biology and interactions
Investigation of the role of novel neuronal proteins in T lymphocyte migration. (NEUROTCELL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 191359.8
EU funding (EUR): 191359.8
Participants: 1
Project status: CLOSED

The applicant has previously worked and published in the area of cell migration and took a career break for family reasons. She now wishes to pursue a career in immunology with a particular focus the study of T cell migration. The host laboratory in Trinity College Dublin (TCD) will provide the applicant with the ideal opportunity to develop essential practical and theoretical skills in this field of research. The host scientist, Dr Aideen Long, has worked in this area for more than 10 years with a considerable track record and high impact publications. Her group has identified three novel proteins that demonstrate a polarized distribution in migrating T cells. The scientific aim of the proposed project is to investigate the functional role of these novel proteins - Synaptopodin, Spectrin beta 1 and Neurofilament Heavy chain in T cell polarization and migration. This will train the Fellow in the use of cutting edge technologies such as proteomics, siRNA and High Content Analysis - a revolutionary technology, which combines automated fluorescence microscopy with multi-parametric analysis. As TCD's expertise in immunology is recognised globally, the research environment and proposed project together with complementary skills training will enhance the fellow's education and professional development. It will allow her both to re-establish her scientific career and to return to Poland with important additional research expertise.

Keywords: health sciences,adaptive immunity,t lymphocyte,inflammation,cytoskeleton,neuron,cell migration,cell polarity,sirna,high content analysis
Engineering of Nanocomposites for a New Energy Conversion Device Joining Fuel Cell and Solar Cell (NANO-FCSC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2016-03-14
Duration (months): 24.0
Total project cost (EUR): 207613.2
EU funding (EUR): 207613.2
Participants: 1
Project status: CLOSED

The overall aim of the Nano-FCSC project is to develop and engineer functional nanocomposite materials for a novel energy conversion technology, which combines the principle of both fuel cell and solar cell, and investigate scientific principles and device mechanisms, including ion and electron transport. Targets of the project are strongly innovative methodologies for the preparation, characterization, testing of advanced nanocomposite materials for joint fuel cell and solar cell device. This project is a multidisciplinary and interdisciplinary research encompassing nanotechnology, materials synthesis, materials characterization, thin film fabrication, device fabrication and performance test (fuel cell and solar cell) and modelling activities. Therefore, the experienced researcher will have exposure to a wide range of experts on nanoscience, fuel cell, solar cell, applied physics and modelling during the whole course of project development. Besides, Nano-FCSC project will generate new fundamental knowledge and foster new prospects and frontiers in the field of fuel cell, solar cell and nanotechnology.

Keywords: nanocomposite,fuel cell,solar cell,g311 materials engineering,c128 nanomaterial