Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
HIGH-TC JOSEPHSON NEURONS AND SYNAPSES: TOWARDS ULTRAFAST AND ENERGY EFFICIENT SUPERCONDUCTING NEUROMORPHIC COMPUTING (JOSEPHINE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Spain,Germany,Sweden
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-05-01
End date: 2028-04-30
Duration (months): 48.0
Total project cost (EUR): 3438122.5
EU funding (EUR): 3438122.5
Participants: 6
Project status: SIGNED

We aim at realizing a novel class of high-temperature Josephson junctions (JJs) that behave as artificial neurons and synapses. These JJs will enable a new neuromorphic computing paradigm, in which neural networks are much faster, more energy efficient and compact than with non-superconducting approaches, and possess novel capabilities (combined sensitivity to light, magnetic and electric fields). Via these rupture ingredients, JOSEPHINE will dramatically enhance the impact of neuromorphics on its broad range of projected applications: from artificial intelligence (where it would allow supercomputer-level processors at a fraction of the environmental cost) to the control of autonomous vehicles, the Internet of Things, and novel medical applications. That constitutes the long-term vision for the science we propose. To reach that goal, we will use different strategies to realize high-Tc Josephson junctions whose weak-links are active and can be changed "in operando" by external stimuli. Those strategies include "weak links" modified by a nanoscale redox reaction, by the motion of domain walls in a ferromagnet, or by locally doping a graphene or a 2D semiconductor. Once realized, these JJs will be implemented and tested in neural networks to demonstrate their performance and their transformative effect on neuromorphics. The proposed strategy exploits recent breakthrough results of the partners (physical effects that will be implemented) and synergizes their complementary expertise via a multidisciplinary approach that marries traditionally distant disciplines: neural network engineering, superconducting electronics, and various facets of solid-state physics (superconductivity, magnetism, Dirac materials, and electrochemistry).

Keywords: superconducting electronics,cuprates,josephson devices,cryogenic memory,proximity effects,graphene,quantum circuits,quantum electronics,
The Spectrum of Fluctuations in Living Matter (LIVING_FLUCTUATIONS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499575.0
EU funding (EUR): 1499575.0
Participants: 2
Project status: SIGNED

Living matter is active: It is driven far from thermodynamic equilibrium by irreversible microscopic processes, such as the action of molecular motors and cell division. This microscopic activity generates nonequilibrium fluctuations, which overwhelm thermal noise and impact biological processes across scales, from intracellular transport to tumour formation. However, unlike in the case of thermal fluctuations, we have no theoretical framework like the fluctuation-dissipation theorem to predict the statistical properties of active fluctuations. Here, I propose to address this knowledge gap by means of theoretical research combined with experimental collaborations organized in two aims. In the first aim, at the subcellular scale, we will predict the spectrum of active noise based on the nonequilibrium binding kinetics of cytoskeletal proteins. To this end, we will coarse-grain a cytoskeletal network model in which detailed balance is explicitly broken at the molecular scale. We will then use the predictions to analyse experimental data and infer features of molecular activity in living cells and in the mitotic spindle. In the second aim, at the tissue scale, we will predict the statistical properties of active pressure fluctuations due to stochastic cell proliferation, which is itself regulated by pressure. We will establish how this mechanical feedback affects the spectrum of the pressure field in a growing tissue. To this end, we will generalize tools from the renormalization group that were originally developed to study nonequilibrium critical phenomena through the Kardar-Parisi-Zhang equation. We will then collaborate with experimentalists to test our predictions by measuring the spectrum of pressure fluctuations in living tissues for the first time. Overall, this research will lay the basis of a stochastic hydrodynamics of living materials and, at the same time, reveal how active fluctuations promote biological functions in cells and tissues.

Keywords: active matter,nonequilibrium statistical mechanics,biological physics,active fluctuations,noise,cytoskeleton,tissues
Unveiling novel metabolite-driven signalling pathways that regulate carbon/nitrogen imbalance associated to plant stress (MetaboSignal)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 261380.64
EU funding (EUR): 261380.64
Participants: 2
Project status: SIGNED

Environmental stresses trigger metabolic changes that alter the internal carbon/nitrogen (C/N) balance in plants to promote tolerance at the expense of growth. However, the metabolic and genetic components involved in the precise coordination of the nutritional status remain largely unknown. MetaboSignal’s aim is elucidating novel signalling mechanisms governing nutrient balance by using C/N stress conditions as a proxy. This 3-year project proposes the integration of molecular genetics and biological chemistry disciplines to identify signalling functions of intermediate metabolites derived from C and N metabolism and characterize new nutritional sensors of C/N balance. Here, several innovative and powerful methods for chemical distribution mapping, proteomics and transcriptomic analyses are integrated in a convergent workflow with gene functional characterization to be carried out in cutting-edge institutions such as University of California San Diego and Universidad Politécnica de Madrid. Implementation of this multidisciplinary proposal will greatly bolster the fellow´s scientific profile and will uncover novel metabolite-controlled signalling pathways useful for knowledge-based improvements on plant nutrition and crop yield of scientific and societal relevance.

Keywords: carbon nitrogen stress nutritional imbalance sugar signalling intermediate metabolites della proteins seedling stablishment
TITAN: Trusted envIronments for confidenTiAl computiNg and secure data sharing (TITAN)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Partnership: EOSC (co-programmed)
Countries involved: Spain,Luxembourg,Serbia,Sweden,Ireland,Finland,Czechia,Germany,France,Italy
Call: Trusted environments for sensitive data management in EOSC (HORIZON-INFRA-2023-EOSC-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 6194379.55
EU funding (EUR): 4999200.97
Participants: 16
Project status: SIGNED

TITAN will enrich the EOSC Interoperability Framework (IF) with a software platform solution for confidential data collaboration and secure and privacy-preserving data processing. The platform will enable access to sensitive data sets from public entities and government agencies and will be compatible by design with the EOSC IF on the technical, semantic, organisational and legal layers. To promote community adoption of TITAN’s open-source software artefacts, the solution will be practically demonstrated in several vertical cross-border scenarios - notably in the public administration and healthcare sector

Keywords: trusted environment,privacy preserving
Powering the METAmorphosis of BUILDings towards a decarbonised and sustainable energy system (META BUILD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Greece,Spain,Italy,Luxembourg,France,Croatia,Türkiye,Bulgaria,Germany,Latvia,Poland,Belgium,Austria
Call: Innovative solutions for cost-effective decarbonisation of buildings through energy efficiency and electrification (HORIZON-CL5-2023-D4-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 15541423.75
EU funding (EUR): 12499988.13
Participants: 41
Project status: SIGNED

The overall vision is to operationalise energy efficiency first principle in the practical context of buildings, towards the decarbonisation of the EU building stock, through: Electrified low-carbon technologies such as heat pumps for the electrification of the building thermal energy demand; Integration of RES & storage; Building digitalisation and intelligence with smart energy management systems. To achieve the ‘META BUILD of the building sector’, we will develop and demonstrate at TRL 6-8 highly cost-effective, integrated and replicable solutions (i.e. Heat Pumps coupled with RES and ES systems) for electrifying thermal energy demand in buildings. Social acceptance and strict adherence to energy efficiency measures will be ensured to promote a sustainable, efficient energy use and an affordable pathway to decarbonise the building-sector heating. A holistic approach addresses challenges throughout the building life cycle, including product manufacturing, energy solution design and engineering, construction, renovation, operation, and maintenance. META BUILD will deliver: KPI-driven assessment methodology & LCA analysis on building electrification; Decarbonisation as a service decision support tool; sound Business Models combined with energy efficiency and electrification; Advanced HP technologies, PVTs & other RES solutions, thermal & second-life battery storage systems; Interoperable framework for electrified ready buildings; Energy management services for RT-monitoring & performance analytics; Demand response, grid interaction & flexibility planning tools; Pro-active maintenance & controls services; Digital Twins for maintaining/enhancing the buildings’ performance; Blueprints & policy recommendations for replication & scalability. Focus will be given on both construction and renovation phases of a building, while META BUILD solutions will be demonstrated and replicated in different types of buildings including 6 Front Runners and 7 Replication Multipliers.

Keywords: heat pumps hybrid photovoltaic thermal second life batteries data driven services digital twins thermal comfort,indoor air quality pro active maintenance smart control demand response
POLARSENSE: Polaritonic compact gas sensor demonstrator (POLARSENSE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-07-01
End date: 2024-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Monitoring gases and particles through the use of smart sensors has a crucial role in a wide range of applications, from environmental control to breath analysis for diagnostics. With the information provided by these sensors, we are able to predict, prevent and act in potentially dangerous situations. In order for the data to be effectively transferred, the gas sensors must be integrated into portable devices with wireless connectivity, and must be miniaturized concurrently. To meet this requirement, the sensors must possess high sensitivity, selectivity, speed, ultra-low power consumption, and compatibility with silicon technology. However, currently no existing technology on the market fulfils all of these criteria. POLARSENSE aims out to develop an optical (infrared) gas sensor demonstrator chip based on a novel graphene electro-polaritonic platform that is designed to address all of the aforementioned technical and commercial requirements. This will be demonstrated through its functionality and performance, with the capability of detecting multiple gases in a scalable, CMOS compatible system with a sensitivity of 0.1 ppm, alongside specific optically active elements and an electrical detector all integrated within one single device. The result is a highly compact and efficient sensing platform that does not require an external photodetector. To achieve this, POLARSENSE will simulate, design, and fabricate a demonstrator chip in accordance with the specifications of our industrial partners, and test with a compact interferometer with a broadband infrared source to evaluate the performance. We will then validate the sensing performance of the demonstrator system with acetone gas in a matrix containing different concentrations of ethanol and/or water vapor that are typically present in breath analyzer and environmental monitoring applications.
Cellular Strategies of Protein Quality Control-Degradation (CellularPQCD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Maintaining the quality of all proteins in an organism is fundamental to life since it ensures tissue function, organismal health, and longevity. Protein quality control (PQC) is achieved by selective degradation of damaged proteins, limiting the formation of protein aggregates and neurodegeneration characteristic of Alzheimer’s, Huntington’s, and Parkinson’s disorders. Important regulators of cellular proteolysis are E3 ubiquitin ligases that target damaged proteins for degradation. However, therapeutically relevant E3 ligases specialized for PQC degradation (PQCD) are largely unknown. PQCD of damaged proteins is a dynamic process that must be coordinated with physiological and environmental challenges to overcome stress-induced proteotoxicity. Despite progress in characterizing regulatory signals for protein degradation, the major challenge in this field is to understand the dynamic rewiring of PQCD pathways under acute and chronic stress conditions. Thus, the overall goal of the proposed research program is to unravel the molecular basis of stress-induced PQCD, which is critical for physiological integrity and health. The mechanistic role of PQC-E3 ubiquitin ligases will be investigated using mammalian cell cultures and the genetic model organism Caenorhabditis elegans, which reflects many conserved human ubiquitin-dependent PQCD pathways and allows for well-defined lifespan studies. This innovative and interdisciplinary research program will combine state-of-the-art proteome analyses with tissue-specific manipulation of stress signals and large-scale genetic studies for identification and characterization of (1) stress-induced PQCD, (2) aggregating damaged proteins, and (3) E3 ligases specialized for PQCD. Importantly, in addition to providing new molecular insights into stress-induced adaptive mechanisms, this research program will lay the foundation for exploring the pathophysiology of aggregation-related neurodegeneration triggered by chronic protein damage.

Keywords: proteostasis,ubiquitin,ups,stress response,protein aggregation
Semi-Transparent Micro-Striped Chalcopyrite Cu(In,Ga)Se2 solar cells for window applications (MISTiCal)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Portugal,Sweden
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-10-02
End date: 2026-04-01
Duration (months): 30.0
Total project cost (EUR): 195973.2
EU funding (EUR): 195973.2
Participants: 3
Project status: SIGNED

While a variety of building-integrated photovoltaics (BIPV) solutions is emerging, with conventional photovoltaic systems already installed on roofs and facades, many modern buildings consist of large areas of windows, which represent an available surface to implement semi-transparent photovoltaic (STPV) modules. Their implementation will permit the production of electricity, and its immediate consumption for the end-user, without problem of transport and eventual loss. Moreover, it will contribute to a better energy autonomy and independency. The MISTiCal project aims to establish efficient semi-transparent solar cells for window applications by developing a novel micro-structured architecture for Cu(In,Ga)Se2 (CIGS) thin-film photovoltaics and the respective fabrication processes. Using CIGS micro-stripes with a width of ~200 micrometers, they are below the resolution of the human eye at a viewing distance above 70 cm, making the window fully transparent to natural daylight. Comparing to other STPV technologies, such as silicon, dye-sensitized (DSSC), organic solar cells (OPV), or ultra-thin CIGS, the micro-structured CIGS STPV presents a good alternative with several strengths such as its industrial maturity and its competitive cost with Si-based solar modules, high efficiency, stability and good aesthetics. The objectives of the MISTiCal project will be (1) to optimize the CIGS device stack for the semi-transparent property, (2) to optimize the micro-structuring of CIGS to demonstrate semi-transparent solar cells, and (3) to assess the performance and the bifacial functionality of the solar cells. The overall goal is to demonstrate a power conversion efficiency of 8% at an average visible transmittance (AVT) of 50%, surpassing the present state of the art for STPV.

Keywords: semi transparent solar cell,building integrated photovoltaics bipv,cigs thin film photovoltaics,window,micro stripes
SUnlight-driven Next Generation Artificial photosynthesis bio-hybrid TEchnology platform for highly efficient carbon neutral production of solar fuels (SUNGATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Poland,Spain,Belgium,Türkiye,Denmark,Netherlands
Call: Efficient and circular artificial photosynthesis (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 5101257.5
EU funding (EUR): 4897007.05
Participants: 10
Project status: SIGNED

Artificial photosynthesis (AP) is a promising approach for solar fuel production, but current systems are inefficient, expensive and unsuitable for industrial deployment. The interdisciplinary SUNGATE consortium of 12 partners from six EU countries and Turkey will overcome these limitations by combining the principles of AP with photoelectrocatalysis and flow microreactor technology, leading to the first modular full-cell continuous flow microreactor technology that requires only sunlight (as an energy source) plus water and CO2 (as simple, abundant feedstocks) for conversion into solar fuels such as methanol and formate. The technology will operate at room temperature and neutral pH using aqueous solutions. In contrast to state-of-the-art photoelectrochemical (PEC) technologies, SUNGATE will not use toxic or critical raw materials, and will combine efficient water oxidation catalysts, with biological components such as photosystem I and enzymes, novel CO2 reducing catalysts and nanostructured diamond-based cathodes to radically improve the efficiency of conversion. The unique modular and scalable design of SUNGATE technology will allow the decarbonised production of solar fuels by increasing the size of the microfluidic PEC device or by numbering up the PEC modules, thus providing the flexibility for diverse applications ranging from decentralised energy infrastructure to closed carbon cycles for industries that emit large amounts of CO2. SUNGATE aims to achieve proof of concept at TRL5, heralding a technology breakthrough that has the potential to secure the future global energy supply at an affordable cost. This meets the central goal of the European Green Deal and the European Climate Law to achieve climate neutrality by 2050. SUNGATE’s diverse mix of academic, RTOs and industry partners will allow the full validation of the technology, including life cycle assessment, as well as effective dissemination and knowledge transfer to accelerate industrial take up.

Keywords: artificial photosynthesis,solar fuels,methanol,renewable energy
Analytic number theory and higher order Fourier analysis (ANTFourier)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1493135.0
EU funding (EUR): 1493135.0
Participants: 1
Project status: SIGNED

Many of the central problems in analytic number theory concern the existence of patterns in the primes or the randomness properties of the Möbius function. The aim of this proposal is to make progress on such questions, using in particular methods from higher order Fourier analysis. Two fundamental conjectures about randomness of the Möbius function are the Chowla and Sarnak conjectures. This proposal aims to make progress on these conjectures and their variants, in particular by studying a conjecture on higher order uniformity of the Möbius function that is closely tied to these problems. Regarding patterns in the primes, the approach in this proposal is to establish new Gowers norm estimates for the primes and other multiplicatively defined sequences. Both quantitative Gowers norm bounds and short interval Gowers norms will be studied. These have potential for various applications, such as a version of the prime tuples conjecture with a short average and convergence results for multiple ergodic averages along the primes.

Keywords: analytic number theory,higher order fourier analysis,gowers norms,prime numbers,additive combinatorics,sieve theory,ergodic averages