Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optimising Robot Performance while Dreaming (RobDREAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Advanced interfaces and robots: Robotics and smart spaces
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Germany,Germany,Spain,Austria,Germany,Sweden
Call: Robotics (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 5401911.0
EU funding (EUR): 5401911.0
Participants: 8
Project status: CLOSED

Sleep! For hominids and most other mammals sleep means more than regeneration. Sleep positively affects working memory, which in turn improves higher-level cognitive functions such as decision making and reasoning. This is the inspiration of RobDREAM! What if robots could also improve their capabilities in their inactive phases – by processing experiences made during the working day and by exploring – or “dreaming” of – possible future situations and how to solve them best? In RobDREAM we will improve industrial mobile manipulators’ perception, navigation and manipulation and grasping capabilities by automatic optimization of parameters, strategies and selection of tools within a portfolio of key algorithms for perception, navigation and manipulation and grasping, by means of learning and simulation, and through use case driven evaluation. As a result, mobile manipulation systems will adapt more quickly to new tasks, jobs, parts, areas of operation and various other constraints. From a scientific perspective the RobDREAM robots will feature increased adaptability, dependability, flexibility, configurability, decisional autonomy, as well as improved abilities in perception, interaction manipulation and motion. The technology readiness level (TRL) of the related key technologies will be increased by means of frequent and iterative real-world testing, validation and improvement phases from the very beginning of the project. From an economic perspective the Quality of Service and the Overall Equipment Efficiency will increase, while at the same time the Total Cost of Ownership for setup, programming and parameter tuning will decrease. These advantages will support the competitiveness of Europe's manufacturing sector, in particular in SME-like settings with higher product variety and smaller lot-sizes. They also support the head start of technology providers adopting RobDREAM’s technologies to conquer market shares in industrial and professional service robotics.

Keywords: manipulation,grasping,dreaming
Training European Experts in Multilevel Bioimaging, Analysis and Modelling of Vertebrate Development and Disease (ImageInLife)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Germany,Spain,Slovakia,Belgium,France,France,France,France,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3562028.64
EU funding (EUR): 3562028.64
Participants: 19
Project status: CLOSED

This proposal sprang from European scientists in both academia and industry who identified a common challenge: setting up a training frame to educate the next generation of imagers in complex biological systems (healthy & pathological), so they are able to master all major aspects of this competitive field and bring important innovations to universities and companies. The long-term goal of any initiative to image biological processes is reaching cellular or subcellular resolution in a complete organism. This is now possible using vertebrate embryos as models and the most recent technological advances as tools. ESRs will be trained by addressing the following scientific bottlenecks and challenges: -Preparing vertebrate embryos (rodent & zebrafish) for optimal imaging -Fine-tuning sensors, reporters and actuators to track cell types, cellular processes and behaviours in living organisms -Developing and implementing new imaging instruments -Analysing complex sets of big-data images to extract relevant information -Using processed images to design computational and mathematical models of development and pathologies -Comparing these models with experimental data and create a feedback loop improving the whole work chain from sample preparation to instrumentation and analysis. This interdisciplinary training is based on an intersectoral organisation of the consortium with partners from academia and companies that need these future experts to develop new instruments, screen drugs and chemicals in living systems and develop software to analyse and model medical images. The full training programme is based on an optimal balance between training through research and many network-wide training events, including conferences with physical presence, digital conferences and monthly videolink events. Consortium members are keen to implement both classical and original outreach activities (eg MOOCs, serious games, Lego designs) to bring state-of-the-art microscopy to the classroom.

Keywords: microscopy,embryo development,cell lineage tracking,morphogenesis,zebrafish,mice,in toto imaging,fluorescent reporters,image processing,complex systems,development and disease modelling
Inherently Flexible X-Ray Imaging Detector using Single Photon Avalanche Photodiodes and Scintillating Fibres (FleX-RAY)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,Romania,Greece,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-09-01
End date: 2024-01-31
Duration (months): 41.0
Total project cost (EUR): 2432237.5
EU funding (EUR): 2432237.5
Participants: 5
Project status: SIGNED

X-ray imaging is a key component of applications ranging from medicine and food to security and industrial non-destructive testing (NDT). Current approaches to X-ray detection however are limited with respect to shape flexibility and material cost. Inherent inflexibility of the digital electronics and scintillating materials used both in charge integrating and particle counting detectors leads to inaccurate imaging of complex geometries due to geometric magnification. This is particularly problematic in industrial NDT where defects in complex shapes are easy to miss, and in medical applications where early detection of abnormalities can make the difference between life and death. In medical applications, the inability to resolve complex features within the human body is offset by higher radiation dosage, thereby increasing health risks. Moreover, current architectures require the hardware and electronic systems to be placed across the beam path. Thus, they need to be radiation-hardened sacrificing pixel density, greatly increasing the cost of manufacturing, limiting shelf life and making maintenance practically impossible. FleX-RAY completely redefines X-ray detectors by introducing an utterly novel design where the hardware and electronics for detection are placed outside of the beam path, greatly reducing material and manufacturing costs. Our architecture achieves unprecedented versatility as multiple grids of fibres can be stacked to enable finer resolutions as well as particle tracking capabilities. Finally, by leveraging fiber Bragg gratings, our detector’s shape can be interrogated in real-time removing the need to know the imaged geometry beforehand. Our project brings together cross-disciplinary expertise in materials, fibre optics, analogue and digital electronics and particle physics to produce the world’s first ultra-flexible, low-cost, self-shape reporting X-ray detector that will enable 10x higher resolution at half the price of current approaches.

Keywords: scintillating fibres,photon counting,3d shape sensing fibre,flexible x ray detector
Senolytic CAR T cells as novel therapeutic concept for solid tumors and senescence-associated diseases. (CARsen)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1818637.5
EU funding (EUR): 1818637.0
Participants: 1
Project status: SIGNED

The adoptive transfer of T cells expressing CD19-directed chimeric antigen receptors (CARs) has yielded remarkable efficacy in patients with hematological B-cell malignancies. CARs are a class of synthetic receptors that reprogram T cell specificity, function and metabolism. Engineered T cells are applicable in principle to other cancers and diseases, but clinical success will critically depend on further progress to overcome current limitations such as antigenic heterogeneity or impaired T cell trafficking and function. We propose to develop CAR T cells targeting senescent cells as a novel therapeutic concept for cancer and senescence-associated diseases. Cellular senescence is a stress-response program characterized by stable cell cycle arrest that serves as a potent tumor-suppressive mechanism. Conversely, accumulation of senescent cells generates a chronic inflammatory milieu, which contributes to a plethora of pathologies, such as liver or lung fibrosis and can even promote tumor progression. Our preliminary data demonstrate that CAR T cells can efficiently clear senescent cells, providing therapeutic benefit in a murine model of liver fibrosis. We thus firmly believe that senolytic CAR T cells have broad therapeutic potential. To this end, we will apply innovative engineering strategies to develop modular CAR designs tailored to senescence-specific requirements. We will determine safety and efficacy of senolytic CAR T cells in murine models of cellular senescence and solid tumors. Importantly, we will evaluate combined treatment approaches of senescence-inducing therapies with CAR T cells targeting senescent and proliferating tumor cells. Finally, we will investigate engineering tools to optimally direct senolytic CAR activity to mediate durable tumor regression. This project combines two emerging concepts of anticancer therapies and goes beyond current applications of CAR therapies. The efforts may lead to promising new therapeutic avenues.

Keywords: adoptive t cell transfer,gene engineering,car t cells,car designs,solid tumors,anticancer therapies,cellular senescence,sasp,senolytics,senescence associated diseases,immunotherapy,translational research
Super Productive Line Printing Inkjet (SUPPLEPRINT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Located in Fiorano Modenese, Italy, our company TOPJET s.r.l. was established in 1990 with a single purpose: designing and manufacturing the best production labelling and printing systems for our customer’s packaging. Our range of solutions goes from inkjet printing to labelling systems and are 100% developed to address the specific requirements of each customer. Thanks to a steady growth (14.5% annual growth in the 2009-2014 period) and cutting-edge, modern and reliable products, TOPJET is currently competing with the industry’s leading manufacturers worldwide. How do we keep moving forward? Our trump card and main competitive edge lies in our proactive, passionate and highly skilled staff whose top priority is considering each customer a partner, and fulfilling their every need. The company is committed to R&D, investing yearly 10% of the sales revenues in new projects, our ongoing goal being to provide innovative and diversified solutions. A quick and efficient technical support service, together with a widespread distribution network, allow the company to have a strong presence in the entire Italian market as well as in Europe and internationally. In 2014, TOPJET had a turnover of €7.7 million. The SupplePrint Inkjet Printing System is a revolutionary, modular packaging printing system that provides the flexibility to switch configurations quickly and easily from one package design, size and material to another, therefore allowing for smaller production batches, greater speed and high resolution graphics at a lower price. While addressing our customers’ needs for customisation and flexibility in printed packaging, SupplePrint will increase TOPJET’s revenue (currently €7.7M) by an additional 27% within 3 years of commercialisation.

Keywords: printing,printed packaging,automation,inkjet,resolution,flexibility,traceability,customisation
SCRUTINIZING VIRUS-CELL INTERACTIONS: FROM ENSEMBLE TO SINGLE-MOLECULE STUDIES (INTERACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Viruses are nano-sized, genome-filled protein containers with metastable mechanical properties. They form by spontaneous self-assembly inside the crowded, heterogeneous environment of the infected cells. While structural characterization of viruses is becoming increasingly more refined, essential questions about the viral life cycle remain unanswered up to date. This includes: (i) how do the capsomeres (capsid proteins) rearrange during the infection cycle of a viral capsid? (ii) What are the interaction forces responsible for successful infection of viral capsids? (iii) Which kinetic parameters govern this process? To address these questions, the present proposal aims to understand the physico-biology behind the binding of viral capsids to their host cell membrane using human adeno virus as a model system. To accomplish these goals I will investigate the structural and mechanical properties of those proteins forming the viral capsids and measure the binding force to the targeted cell membrane. High-speed atomic force microscopy (HS-AFM) will allow me to directly observe the ensemble of proteins in action at high spatio-temporal resolution and under near-to physiological conditions. At the same time Single Molecule Force Spectroscopy (SMFS) will allow to measure directly the magnitude of forces involved in the interactions. Having access to the information on structure as well as to the unbinding dynamics of the capsid proteins, I will be able to build a kinetic model of the first steps of viral infection at the single-molecule level.

Keywords: physical virology,virus cell interaction,viral infectivity,nanomechanics,bionanotechnology,human adeno virus
Crystalline and vitreous silica films and their interconversion (CRYVISIL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2022-06-30
Duration (months): 78.0
Total project cost (EUR): 2484375.0
EU funding (EUR): 2484375.0
Participants: 1
Project status: CLOSED

Silicon is the most abundant element in the earth’s crust. Its oxide, silica (SiO2) is the basis for most minerals of the earth’s crust, and also for a number of technological applications ranging from window glass, via electronics to catalysis. The structure of crystalline materials such as quartz or silica-based minerals is well understood due to the application of scattering techniques such as x-ray or neutron diffraction, for example, which allow accurate structure determinations. Silica, however, also forms glasses, which are amorphous or vitreous. Its structure is not well understood. In fact, diffraction techniques have only been able to deliver pair correlation functions, which reveal the density of a material around a given atom, but do not allow a detailed reconstruction of the atomic structure as in the case of crystalline materials. Until recently, a real space image of a silica glass with atomic resolution had not been recorded. Using scanning probe techniques applied to a thin silica film grown atomically flat on a metal substrate, it has been possible to reveal, for the first time, an atomically resolved image of vitreous silica. Both, a crystalline as well as a vitreous phase have been imaged. With this system, it is now possible to address the transition from a vitreous state to a crystal-line in real space by developing a scanning probe microscope that allows the study of its structure over a wide range of temperatures ranging from cryogenic temperatures to 1500 K. It is the purpose of this grant application to build such a device and apply it to the crystal-glass transition and the study of vibrational properties. This instrument may also be used to address a number of scientific problems related to other glass-formers, such as borates and the influence of silica modifications by atom doping, for example.
Challenging the Standard Model using an extended Physics program in LHCb (BSMFLEET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 1499855.0
EU funding (EUR): 1499855.0
Participants: 1
Project status: CLOSED

We know that the Standard Model (SM) of Particle Physics is not the ultimate theory of Nature. It misses a quantum description of gravity, it does not offer any explanation to the composition of Dark Matter, and the matter-antimatter unbalance of the Universe is predicted to be significantly smaller than what we actually see. Those are fundamental questions that still need an answer. Alternative models to SM exist, based on ideas such as SuperSymmetry or extra dimensions, and are currently being tested at the Large Hadron Collider (LHC) at CERN. But after the first run of the LHC the SM is yet unbeaten at accelerators, which imposes severe constraints in Physics beyond the SM (BSM). From this point, I see two further working directions: on one side, we must increase our precision in the previous measurements in order to access smaller BSM effects. On the other hand; we should attack the SM with a new fleet of observables sensitive to different BSM scenarios, and make sure that we are making full use of what the LHC offers to us. I propose to create a team at Universidade de Santiago de Compostela that will expand the use of LHCb beyond its original design, while also reinforcing the core LHCb analyses in which I played a leading role so far. LHCb has up to now collected world-leading samples of decays of b and c quarks. My proposal implies to use LHCb for collecting and analysing also world-leading samples of rare s quarks complementary to those of NA62. In the rare s decays the SM sources of Flavour Violation have a stronger suppression than anywhere else, and therefore those decays are excellent places to search for new Flavour Violating sources that otherwise would be hidden behind the SM contributions. It is very important to do this now, since we may not have a similar opportunity in years. In addition, the team will also exploit LHCb to search for μμ resonances predicted in models like NMSSM, and for which LHCb also offers a unique potential that must be used.

Keywords: lhcb,flavour physics,non minimal flavour violating new physics
Interacting relativistic quantum dynamics via multi-time integral equations (Multi-time Integral Eqs.)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2019-05-31
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

Multi-time wave functions are quantum-mechanical wave functions with N space-time arguments for N particles. They were suggested by the Nobel laureates Dirac, Tomonaga and Schwinger as a particularly natural way of achieving manifest Lorentz invariance in the Schrödinger picture. While for a long time it was not clear how to obtain consistent interacting dynamics for multi-time wave functions, this has changed recently when a series of papers has clarified the theory of multi-time Schrödinger equations and provided the first interacting toy models. This project aims, with the long-term goal of a rigorous multi-time formulation of quantum field theory in mind, at improving on these models by considering the possibility of integral equations to formulate interacting dynamics for multi-time wave functions of N=2 particles. This is especially promising, as integral equations avoid a restrictive consistency condition that one faces for differential multi-time equations. Furthermore, the typical ultraviolet divergencies of quantum field theory are avoided. The objectives are (1) to study the existence of solutions of a particular integral equation similar to the Bethe-Salpeter equation, (2) to assess whether the integral equation is compatible with a probabilistic meaning, as well as (3) to determine the classical limit of the integral equation and to compare it with the action-at-a-distance formulation of classical electrodynamics due to Gauß, Fokker, Tetrode, Wheeler and Feynman. Objective (1) shall be approached using the theory of Fredholm integral equations, as well as partial results in the physics literature. For (2), suitable conserved tensor currents with a positive density component shall be constructed. (3) shall be reached by studying wave packets concentrated around the classical world-lines of particles using (and extending) functional-analytic methods of the classical limit, such as Hagedorn wave packets and Wigner functions.

Keywords: relativistic quantum mechanics,integral equations,relativistic wave equations,bethe salpeter equation,continuity equations and probability conservation,action at a distance electrodynamics