Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mantras in Religion, Media and Society in Global Southern Asia (MANTRAMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,Austria,Germany,United Kingdom
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-09-01
End date: 2030-08-31
Duration (months): 72.0
Total project cost (EUR): 9651263.0
EU funding (EUR): 9651263.0
Participants: 4
Project status: SIGNED

Over 4 million people in Europe, including Hindu, Buddhist, Sikh minorities and Yoga practitioners, use mantras—sacred utterances, formulas, or syllables—for the purposes of ritual, prayer, contemplation and wellness. The term “mantra” itself has entered the vocabulary of most modern European languages. But how do mantras work? Where do they come from, and how did they spread around the globe? Despite their ubiquity and relevance, mantras have seldom been studied in their own right. This project will produce an unprecedented global history and anthropology of mantras, grounded in the PIs’ expertise on the very places and traditions where mantras originate–southern Asia, where mantras have been used in rites, meditation, worship, and healing for more than 3000 years. As mantras have been transmitted through diasporic networks, new religious movements, yoga and the internet, they have become central to religion and culture worldwide, while they also play a key role in traditional medicine and identity politics. Most scholarship to date has approached mantras through language and philology, privileging Sanskrit texts from elite contexts. Yet mantras have always been diverse, multimodal and multisensory, manifesting in manuscripts, on stones, in the voice through chanting, in the mind through meditation, and on the body through amulets, tattoos, and clothing. Bringing together leading scholars working across disciplines and cultural regions, this 6-year project will create sonic, visual and digital textual archives on the transcultural and multisensory lives of mantras, together with an exceptional array of academic deliverables and a museum exhibition. Raising awareness of mantras’significance from their origins in ancient South Asia to their modern ramifications in the global North, the MANTRAMS project will produce the first-ever scientific project entirely dedicated to understanding the relevance of mantras at a global scale.

Keywords: asian studies indology sound studies cultural anthropology
Human-centred generative Ai fraMework for culturaL industriEs’ digital Transition (HAMLET)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: Greece,Cyprus,Austria,United Kingdom,Netherlands,Germany
Call: Leverage the digital transition for competitive European cultural and creative industries (HORIZON-CL2-2024-HERITAGE-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 4163602.92
EU funding (EUR): 3927100.75
Participants: 12
Project status: SIGNED

Human-centred generative Ai fraMework for culturaL industriEs’ digital Transition (HAMLET) aims to democratize access to Generative AI in Europe's Cultural and Creative Industries (CCIs). Its mission is to make Generative AI benefits accessible to entities of all sizes, in order to foster a sustainable digital transition. The strategy involves integrating a digital collaboration platform, the "HAMLET Collaborative Community Hub" enabling entities across different sectors to pool investments, share facilities, exchange competencies and employ shared investment and profits-based collaboration models. In parallel, HAMLET produces 7 diverse AI Enablers for CCIs as demonstrators of the framework, which streamline the creative process. These enablers are designed to be integrative, promoting collaboration by facilitating seamless interactions and project co-creation among various CCI stakeholders. By intertwining these two core components, HAMLET not only provides the technological infrastructure necessary for embracing digital transformation but also cultivates an ecosystem where collaboration and shared success are the norms. Moreover, HAMLET is committed to exploring and researching novel business models, including mechanisms for profit sharing and equitable distribution of benefits derived from collaborative efforts, aiming to lower barriers to AI adoption and to establish sustainable frameworks that incentivize shared success and innovation. This cohesive approach ensures that barriers to adopting AI technologies are significantly lowered, enabling a more inclusive and dynamic creative sector that is equipped to navigate the complexities of the digital age. Through HAMLET, smaller actors of the European CCIs are empowered to explore new horizons of creativity and innovation, solidifying Europe's position as a global leader in cultural and creative excellence." HAMLET will be tested through 4 pilot cases involving different CCI sectors across 4 countries in Europe.

Keywords: cultural and creative industries,generative ai,human centered digital transition,immersive technologies,audience engagement,game development,performing arts
Voices of Spanish Poets: Vocal Archive and Experimental Study on Poetry Reading (VSP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

"Voices of Spanish Poets" aims to present a first experimental study of Spanish poetry reading through the instruments of Digital Humanities. The main goal of VSP is to store, enhance and explore the recorded voices of XX century and contemporary Spanish poets using an interdisciplinary approach. The relationship between text and reading is crucial for appreciating the deeper musical core of poetry. Although it has been treated through mainly theoretical approaches, more recent international experimental studies, based on audio recordings, offer novel avenues of exploration which still require further development. While poetry vocal archives constitute a major source of input for the main schools working on this issue, research dealing with Spanish poetry reading has not yet been carried out. The VSP project fills this knowledge gap by means of its four main objectives: to create a dynamic digital platform for the study and listening of Spanish poetry reading; to conduct an Experimental Phonetic study on the VSP archive, developing a first History of Spanish poetry reading; to study poetry reading through an Experimental Psycholinguistic, Cognitive and Psychophysiologic approach, considering the perception and representation of the text through listening; to integrate these two last research approaches. This proposal will combine qualitative, quantitative, and comparative approaches. Based on innovative and interdisciplinary methods, VSP can make a great difference in the success and dissemination of the research field of poetry reading study. The VSP platform aims to be an important digital resource for listening and learning of poetry. The integrated experimental studies can contribute to the improvement of performance and teaching strategies and innovate the approach to reading poetry. The project is suited to further applications and can be the starting point for future collaborative research groups and wider multi-language projects.

Keywords: phonetics psycholinguistics and cognition digital humanities poetry reading vocal archives
Endogenous Retroelements As Transcriptional Parasites And Modulators Of Host Immunity (EndoRPHIm)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1999415.0
EU funding (EUR): 1999415.0
Participants: 1
Project status: SIGNED

Almost half of our genome is occupied by ancient viral sequences that can be mobilized under certain conditions and either jump or copy themselves from one location to another. A group of these mobile genetic elements is called endogenous retroelements. Mobilization of retroelements like LINE1 has been shown to cause cancer via insertional mutagenesis. In recent years LINE1 activation has also been associated with the development of inflammatory diseases and inflammation-driven ageing. This means, we collected substantial evidence that half of our genome can potentially make us sick. Nevertheless, we keep replicating these sequences with every cell division at great energetic cost, suggesting that keeping them provides an evolutionary advantage. In my project I will investigate if sporadic retroelement transcription in healthy cells serves a physiological role in priming the immune system through the constant sensing of retroelement-derived nucleic acids by intracellular nucleic acid sensors. My team and I will investigate how retroelement transcription is regulated in response daily life stresses like virus infections or DNA damage. I propose that instead of regulating transcription themselves, retroelements are largely regulated by canonical gene expression. In mouse models we will investigate how retroelements are sensed by the innate immune system and if this has functional consequences for establishing protective and pathologic immunity. Furthermore, we will investigate the exact molecular mechanism, by which retroelement-derived single stranded cDNA activates the innate immune system, which is currently not understood. Our project involves the development of a new deep sequencing workflow for identification of the genomic origin of retroelement transcripts and a new mouse model to study endogenous LINE1 elements in vivo. I believe that my project can fundamentally change our view on the role of endogenous retroelements as modulators of host immunity.

Keywords: retroelements,interferon,inflammation,ageing,nucleic acid sensing
Deciphering the dynamic-plasticity and heterogeneity of cancer-associated fibroblasts (DynamHet)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1775190.0
EU funding (EUR): 1775190.0
Participants: 1
Project status: SIGNED

Cancer-associated fibroblasts (CAFs) are one of the most abundant and versatile cell types in the tumour microenvironment (TME), where they crosstalk with stromal cells and actively participate in tumour development. Because of their assumed pro-tumourigenic functions, CAFs have long been considered an attractive therapeutic target. However, recent evidence indicates that multiple CAF subpopulations showing inflammatory, myofibroblastic, vascular, antigen-presenting, and immunosuppressive phenotypes co-exist within the same tumour, – with some promoting and other restricting tumour growth; thus, making their targeting challenging. How CAFs change dynamically as cancers evolve, and how this may affect the overall tumour heterogeneity, remains unaddressed. Therefore, the main goal of DynamHet is to elucidate the origin and evolution of CAF heterogeneity and to decipher the mediators and mechanisms that regulate CAF plasticity as the tumour advances. This is crucial for the development of effective therapies aimed at reprogramming CAFs towards therapeutically favourable phenotypes and will constitute a great breakthrough in the field of oncology. Hence, DynamHet aims to 1) decipher the origin of CAF heterogeneity by performing clonal tracing and by generating and characterising CAF subtypes starting from human induced pluripotent stem cells; 2) dissect CAF-TME crosstalk by generating 3D patient-derived organoids and spheroids and by analysing their secretome and transcriptomic profiles using high throughput technologies and computational analysis; and 3) reprogramme CAFs by genetic manipulation in favour of therapeutically advantageous subpopulations as a novel therapeutic approach. DynamHet is an ambitious and feasible project that stands as a pioneer in the new concept of deciphering the origin and reprogramming the dynamic heterogeneity of CAFs towards the development of innovative precision medicine approaches in cancer.

Keywords: cancer associated fibroblasts,tumour microenvironment,heterogeneity,cell plasticity,cell crosstalk,target therapy,cholangiocarcinoma
Using in-depth genomic knowledge to understand and Using in-depth genomic knowledge to understand and predict short- and long-term responses to climate change in a commercially targeted marine species (EVOLOCT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: SIGNED

Making the most of genomic tools to understand and predict species response to global change is increasingly important, especially in exploited marine species. In EVOLOCT, I aim to determine the genomic basis of local adaptation, while understanding the past, present, and future population dynamics of Octopus vulgaris. This ecologically and economically significant species has recently expanded northwards in the northeast Atlantic, possibly due to climate change or human exploitation, yet the exact causes and the population stability remain unknown. Moreover, while the importance of structural variants (SVs) has been increasingly recognised in underlying ecotypes and cryptic population structures, SVs remain poorly represented in eco-evolutionary studies. To address these gaps, I will integrate modelling, genomics, and environmental data to characterise present population structure and dynamics, reconstruct their demographic history, and predict their future distribution, abundance, and vulnerability. Pushing the boundaries of current genomics studies, I will incorporate SVs beyond the classic SNPs while combining simulated data with empirical data, as a powerful and comprehensive technique in predicting short- and long-term responses to climate change. I will hone my skills at the host lab of Dr Mérot alongside Prof Charrier and Dr Le Luyer, French experts in evolutionary biology and ecology. My secondment with Asst Prof Oomen in Sweden will expand my skills in modelling and SV analyses. Through these collaborations, I will learn new multidisciplinary approaches and techniques in modelling and genomics. EVOLOCT will undoubtedly enable me to gain a competitive advantage in establishing my career in the dynamic and critical field of evolutionary ecology. Finally, EVOLOCT will greatly advance our understanding of the genomic and evolutionary basis underlying local adaptation while allowing scientifically-informed management of exploited marine species like octopuses.

Keywords: evolution fisheries ecology genomics genomic architecture local adaptation molecular ecology population structure structural variation
Advancing in the CHallenge of Improving Lymphoma and LEukemia Survival (ACHILLES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Bulgaria,Italy,France,Portugal,Netherlands,Germany,Sweden,Greece,Romania,Serbia,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-12-01
End date: 2029-11-30
Duration (months): 48.0
Total project cost (EUR): 4511654.13
EU funding (EUR): 4251589.2
Participants: 33
Project status: SIGNED

ACHILLES is a Doctoral Network (DN) program designed to train the next generation of leaders in hemato-oncology, with a focus on the development of novel therapeutic solutions for hematological malignancies. The network brings together 14 institutions from 10 EU countries and one associated state, along with partners from the biotechnology and drug discovery sectors, including two European policy leaders in hematology, the European Hematology Association (EHA) and the European School of Hematology (ESH). Through this collaboration, ACHILLES will train 16 Doctoral Candidates (DCs) to develop essential skills in experimental hemato-oncology, including the design, development, and preclinical validation of innovative therapies. ACHILLES is structured around three key scientific objectives (SOs): (1) creating novel experimental models and analytical methods, (2) exploring the oncogenic mechanisms of hematologic malignancies, and (3) developing and validating new therapies, especially targeted treatments for leukemia and lymphoma. The program will integrate cutting-edge technologies such as AI, multi-omics, and computational modeling to push the boundaries of current research and therapy development. These innovations will be applied to generate better diagnostic tools, predict treatment responses, and optimize therapeutic strategies. With a patient-centered approach, ACHILLES aims to foster both academic and industrial collaboration, bridging gaps between scientific research and clinical application. This initiative aligns with the EU's Beating Cancer Plan, with a particular focus on improving survival rates and treatment accessibility, especially in Widening Countries. Through strong academic-industrial partnerships, ACHILLES will help create a sustainable impact on the field of hemato-oncology, advancing research, therapies, and ultimately the health outcomes of leukemia and lymphoma patients worldwide.

Keywords: leukemia,lymphoma experimental therapeutics drug discovery immunotherapy hematologic malignancies
High Gains, high Risks, for whom? A holistic approach to the Inequalities Of Working While Studying Trajectories (GROW) (GROW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

Across Europe, 11 million university students (80%) combine their studies with paid employment. A highly relevant question, therefore, is how students’ lives are affected by student employment in the long run. Yet, existing segmented research has failed to provide a comprehensive approach to assess the implications of student employment for students later in life: It has remained unclear who gains and risks when working while studying, and under which conditions. GROW will break with these previous conventional approaches by taking on a holistic approach which will jointly analyse the positive and negative effects of student employment for educational and labour market outcomes. GROW will bridge segmented theoretical views from psychology, sociology, and labour economics by implementing a life course approach, creating a more comprehensive, nuanced, and interdisciplinary understanding about the implications of student employment for students’ lives. To do so, it uses multichannel sequence analysis, and mixture hidden Markov modelling to jointly analyse educational and labour market trajectories based on high-quality longitudinal data from four carefully selected European countries belonging to three different welfare states: Liberal (UK), Conservative (the Netherlands, Germany), and Social Democrat (Finland). It emphasises gender and social origin differences in patterns and implications of student employment, as well as differences across students’ fields of study, and national contexts. The project includes an ambitious dissemination and communication plan targeting academic scholars, policy makers, managers of European Higher Education, and Higher Education Students. As such, the GROW project aims at strengthening the Social Dimension of the European Higher Education Area and contributes to the UN Sustainable Development Goals 4 (quality education) and 10 (reduce inequality).

Keywords: student employment,higher education,working while studying,social inequality,life course,sequence analysis