Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Era-net Transport III (ENTIII)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Coordination and support actions
Partnership: ENTIII (ERA-NET)
Countries involved: Netherlands,Austria,Denmark,Sweden,Türkiye,Germany,France,Poland,Finland,Spain,Belarus,Israel,Czechia,Belgium,United Kingdom,Spain,Bulgaria,Greece,Germany,Norway
Call:  (FP7-ERANET-2012-RTD, 2012)
Start date: 2012-11-01
End date: 2016-04-30
Duration (months): 42.0
Total project cost (EUR): 2669967.07
EU funding (EUR): 2299393.0
Participants: 26
Project status: CLOSED

Era-net Transport (ENT) has evolved since 2004 into a service platform for Programme Owners and Managers, providing the required framework for initiating and implementing transnational research and innovation funding collaborations ENTIII will further strengthen the foundation of the ERA, engaging 20 partner countries and regions, represented by Europe’s most relevant national transport research and innovation programmes. ENTIII will: • Prepare and launch large-sized annual flagship initiatives, coordinated with the SST programme, with a size of ideally some 10 million EURO. Within ENTIII the launch of 2 flagships is envisaged. A flagship might include multiple topics; • Prepare and launch small- and medium-sized transnational research and innovation funding initiatives. Within ENTIII the launch of at least 4 such funding initiatives is envisaged; • Explore and –if possible- deploy new ways, geometries and settings for transnational cooperation and funding, e.g. through deployment of Structural and Cohesion funds; • Enlarge the visibility of national research and innovation funding activities, their results and achievements and of the added value of transnational collaborations through ENT and thereby increased impact in the ERA. ENTIII will build on the achievements, networks and tools of the previous ENTs and on the acquired experiences and know-how. ENTIII will step beyond through: • Expanding the network of European countries and regions and intensify the support for (new) ENT partners; • Launching more large-scale funding initiatives involving budgets of up to 10 million EURO; • Enhancing the support for programme owners and managers in partner countries and regions to better fit their funding schemes and procedures to transnational funding collaborations.

Keywords: era-net transport,transnational research,innovation funding cooperation,transport research,flagship initiatives,framework.
ERASysAPP - Systems Biology Applications (ERASYSAPP)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Coordination and support actions
Partnership: ERASYSAPP (ERA-NET)
Countries involved: Germany,Luxembourg,Spain,Sweden,Iceland,Switzerland,Latvia,Germany,Netherlands,Estonia,Norway,Romania,Cyprus,Sweden,France
Call:  (FP7-ERANET-2012-RTD, 2012)
Start date: 2013-01-01
End date: 2015-12-31
Duration (months): 36.0
Total project cost (EUR): 2276590.2
EU funding (EUR): 1999862.0
Participants: 18
Project status: CLOSED

The main objective of the ERANET proposal “Systems Biology Applications – ERASysAPP” (app = application = translational systems biology) is to promote multidimensional and complementary European systems biology projects, programmes, and research initiatives on a number of selected research topics. Inter alia, ERASysAPP will initiate, execute and monitor a number of joint transnational calls on systems biology research projects with a particular focus on applications – or in other words so called “translational systems biology” research approaches (application-oriented and/or industry-relevant). The joint call proposals and their respective topics will be on applied aspects of complex biological processes in microorganisms, plants, and animals. As common feature, all addressed proposal topics will tackle biological and physiological processes of common interest in the field of life sciences and biotechnology. In order to reach our ambitious goals, ERASysAPP has been outlined to initiate novel activities and impulses for SB in the ERA. Taking past successful developments and achievements into account, ERASysAPP will be able to continue and build on work, which has been performed by the previously funded successful ERANET on SB, ERASysBio and its spin-offs ERASysBio+, SysMo and SysMO2 (www.erasysbio.net). This is advantageous, since it allows for the efficient use of past experiences and tangible results of ERASysBio and will guarantee for maximum synergistic effects. Although building on the improvements of ERASysBio, ERASysAPP will provide a bundle of novel aspects, ideas, activities and sustainable new features to push SB towards new challenges and horizons. Apart from setting up joint transnational calls and giving impulses for industry to apply more SB approaches, ERASysAPP will focus on horizontal topics such as improved data management and sharing, training and networking with national, transnational, and EU SB initiatives as well as programmes outside the ERA.

Keywords: eranet,systems biology,joint transnational calls,translational and industrial-relevant systems biology,application-oriented systems biology,data management,standards,academia-industry link
Comprehensive molecular analysis and differentiation of the eukaryotic microbiota in faecal samples from human cohorts to establish the role of intestinal eukaryotes in health and disease. (GUT18S)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The development of Next Generation Sequencing (NGS) methods has enabled a precise identification of the enteric flora in humans and animals, partly owing to a 16S (bacterial small subunit ribosomal DNA) strategy. However, our insight into eukaryotic endobiotic organisms remains relatively limited. Molecular biological studies of genomic DNA extracted from faecal samples have given us an idea of the diversity among parasites and yeasts present in the human intestinal tract. This knowledge is necessary in order to expand on our understanding of the evolution, ecology and, perhaps most importantly, clinical significance of intestinal eukaryotic organisms, many of which may colonise the host for months or even years, and to evaluate our ability to detect them using current state-of-the-art methods. This insight is, however, still reached primarily by PCR and dideoxy-/Sanger sequencing despite the many limitations of this technology. To date, there have been no studies employing NGS methods for the investigation of the diversity of endobiotic eukaryotes. This is probably partly due to the fact that a broad 18S strategy – similar to the 16S strategy – involves unwanted amplification of human DNA. However, at the Laboratory of Parasitology, Statens Serum Institut, we have developed an 18S PCR method, which avoids amplification of human DNA. This means that PCR products can be analysed using NGS technology and bioinformatics tools without spending resources on data which have no or little interest. We now wish to validate and use this method to investigate the diversity of the human, eukaryotic enteric flora from different cohorts, including patients with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), non-IBD/non-IBS diarrhoea and healthy individuals. The results are expected to have a vast impact on the clinical and diagnostic management of intestinal endosymbionts, and to assist in further clarifying the role of these organisms in health and disease.

Keywords: l607 microbiology,l610 parasitology,l702 diagnostic tools,l210 bioinformatics,l804 biodiversity - comparative biology
Trade Preferences as Development Aid: Theory and Evidence (TRADE AS AID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Over the last 10 years the use of Special Trade Preferences – the granting of lower import tariffs to specific countries – has increasingly been used as a tool to encourage development in developing countries, primarily in Africa. Yet, despite the popularity of these tools - practically all sub-Saharan countries receive some form of special trade preferences - we have little understanding of how well they work, both in terms of transferring wealth and encouraging growth. On what basis should they be evaluated? How should they be designed to be the most effective? Can they be superior to alternatives of traditional foreign aid? We seek to answer these questions in three ways. First, we develop a theoretical model that specifically allows for varying types of export goods, in particular in the use of labor and (potentially imported) inputs as requirements on the use of imported intermediated inputs is an important feature of special trade preferences. Second we use two changes in trade policy – the removal of tariffs on fabric for a number of African Countries with the African Growth and Opportunity Act (AGOA) of 2000 as well as the expiration of fabric quotas primarily for Asian competitors in 2004 – to test the predictions of the model. To test the data we will use a highly disaggregated data set containing information on volume, type of imports and price, of imports into the US from a large set of exporters. Third we design a theoretical model that allows for growth enhancing effects of policy and study optimal policy in this context. Preliminary theoretical results indicate that the current design of AGOA – with no requirements on third party inputs – encourages the production of products with a large imported share of fabric and the removal on quotas for Asian competitors in 2004 pushed African exports into cheaper exports. Both of these results find preliminary support in the data.

Keywords: development aid,trade policy,special trade preferences,growth theory,structural estimation,e116 international trade - economic geography
Enhancement of mesenchymal stem cell therapy for graft versus host disease (MSC_GVHD_ENHANCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-06-02
Duration (months): 39.0
Total project cost (EUR): 81250.0
EU funding (EUR): 81250.0
Participants: 1
Project status: CLOSED

Steroid resistant acute Graft versus Host Disease (GvHD) is a very serious complication associated with allogeneic haematopoietic stem cell transplantation. There is no established consensus on the therapy for this disease and the prognosis for these patients is poor. Early reports of MSC therapy for acute GvHD involving small numbers of patients were promising, however, results from large scale multi-centre phase III trials have questioned the therapeutic efficacy of MSC therapy for GvHD. Our hypothesis is that MSC require licensing for therapeutic efficacy in GvHD. This project addresses a number of very important and clinically relevant questions; Why are IFN-gamma licensed MSC more efficacious in the treatment of acute GvHD in pre-clinical models? What are the differences between licensed and unlicensed MSC that facilitates the enhanced efficacy? The final element that this project will address is whether or not correlates of MSC therapeutic efficacy can be identified and translated into the clinic. This research is both internationally competitive and innovative in that no correlates have been identified for MSC therapeutic efficacy and the provision of such information would transform the field of MSC therapy for the treatment of GvHD.

Keywords: stem cell therapy,immunosuppression,translational medicine,graft versus host disease
Taxation, Heterogeneity and Employment (THE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of this project is to study the proper design of benefit and tax programs that promote employment and reduce inequality when individuals are heterogeneous in several dimensions. To do so, we will develop original mathematical models some of which will relate optimal taxation theory to other strands of economic theory (e.g., modern labor economics) and to the literature about equality of opportunity, which lies between social choice theory and philosophy. The nature of the assumed unobserved heterogeneity between individuals is very important for the predictions derived from optimal taxation models. Optimal income tax problems typically restrict individuals’ heterogeneity to one-dimension: their innate ability. Although incentives problems with multi-dimensional heterogeneity (a.k.a. multidimensional screening problems) are empirically relevant, they are notoriously very hard to treat. The THE project aims at (1) elaborating a toolbox to solve these problems and (2) developing a wide range of applications for this toolbox. To solve multidimensional screening problems, we propose to: (i) develop recent results obtained using a random participation framework, (ii) build up on the type aggregator technique and (iii) extend the techniques used in the literature on optimal transportation. Beside these technical contributions, the project will allow us to address three original applied economic questions. First, what is the tax schedule over the entire earnings distribution that satisfies equality of opportunity? Second, what is the optimal tax schedule when there are both skill heterogeneity and gender-specific responses in terms of labor force participation decisions? Third, should workfare be used when labor supply is simultaneously modeled along the participation margin (decision to enter or not the labor market) and the intensive margin (i.e. people decide on their labor hours)?

Keywords: optimal tax theory,employment,multidimensional heterogeneity
Complex Dynamics of Swarming Bacteria in Three Dimensions (3D SWARMING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Motile bacteria are able to colonize surfaces using various types of motility. ‘Bacterial swarming’ is the most rapid method, involving an organized, hyperflagellated-based cell motion and collective secretion of bio-surfactants. During swarming, bacteria exploit hydrodynamic interactions; they move in whirls and jets similarly to flocks of birds and schools of fish. Hundreds of cells migrate on the surface in dynamic clusters and form either a single layer or multiple layers, depending on the strain and growth conditions. Past work, which used particle tracking methods to analyze cell trajectories, showed clear group benefits. However, those studies were largely limited to quasi two-dimensional imprecise assumptions and to extreme sample manipulations, all of which combined to yield unnatural habitats. Consequently, it is not clear how swarming cells migrate in a real three-dimensional colony. Here I will study bacterial swarming in unconstrained natural habitats. The methodology is based on mixing green fluorescent protein (GFP)-labelled motile bacteria with wild type bacteria and tracking their three-dimensional trajectories using a specially designed microscope setup and sophisticated computer programs. This setup will enable me to explore whether the movement of a single cell within a multilayered swarming colony is influenced by its neighbors and to discover whether groups of cells tend to disperse or to build small localized sub-communities if conditions are adverse. Sophisticated data analysis will clarify whether bacteria move only within one layer inside the multilayered swarm or whether they migrate up and down, switching from layer to layer. By performing the experiment with added antibiotics, the results are expected to show how bacteria join and collectively benefit for the survival of the strain.

Keywords: p219 biophysics,l106 biophysics,l609 bacteriology,swarming,particle tracking
Adaptation genomics of trophic polymorphism (GEN ECOL ADAPT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2017-08-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Identifying the determinants of species diversification is one of science’s most pressing questions. Biodiversity research has direct implications for our understanding of the origins of species, unequal species richness and the origins of phenotypic and evolutionary novelty, and is therefore an FP7 research priority. Critical elements in understanding the evolution of biodiversity are the environmental and genetic factors that influence adaptation. Similarly, we need to understand these ecosystem components in order to mitigate biodiversity loss under rapid climate change. The latest advances in DNA sequencing technology make it possible to study the genomes of non-model species (i.e. populations in nature) and the genetic bases of their ecological diversity. In this proposal, novel DNA sequencing approaches will be used to investigate long-standing, compelling questions of ecology and evolution. Specifically, the proposal seeks to address two inter-connected objectives in the genomics of adaptation: 1) to determine differential gene expression associated with rapidly evolving and phenotypically plastic trophic polymorphisms; 2) to quantify genetic variation and its response to selection in the divergence between trophically polymorphic species, and then to identify its arrangement in the genome. The study organisms are polymorphic species of salmonid fishes native to Europe. The Researcher will be hosted by the Institute for Biodiversity, Animal Health and Comparative Medicine, University of Glasgow. This is a world-class research facility for the study of ecology and evolution, and will subsequently integrate the Researcher. The Researcher will bridge research priority areas across the University and foster regional and international collaborations. Launching from this proposed project, the fellow will develop an innovative and pioneering research programme that will stimulate a lasting professional and scientific development.

Keywords: v304 conservation biology - ecology - genetics,v309 systems evolution - biological adaptation - phylogenetics - systematics,l201 genomics - comparative genomics - functional genomics
Niche Management Policies for Sustainability Transitions in Socio-Technical Systems: A Simulation-based Analysis of Complex Dynamics (NICHES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The growing size and complexity of socio-technical systems such as energy and transportation, as well as rising concerns about the sustainability of the ways these systems function, create an increasing need for strategies and policies that would facilitate the penetration of sustainability innovations in these systems. Niche-based policies (e.g. strategic niche management (SNM)) that advocate nurturing innovations in protected niches are among such novel policy approaches. Despite being an intuitively appealing approach, its application is not straightforward since there are a set of key interrelated decisions regarding implementation such as size of the niche, the extent of support for an innovation, timing for support withdrawal, and pace of niche up-scaling. In the current state of the art, there is a remarkable absence of specific guiding principles for making such key decisions, and this limits the extent of utilization of niche management policies for facilitating sustainability transitions in socio-technical systems. This absence can mainly be attributed to the dynamic complexity of the innovation development and diffusion processes in the context of socio-technical systems. This research aims to analyze niche management strategies, and to develop a set of specific guidelines for designing and implementing successful strategies under different circumstances in order to facilitate the adoption of sustainability innovations. The analyses will be conducted using an ensemble of simulation models that capture the dynamic complexity of the innovation adoption process. A large set of scenario experiments will be considered in order to make inferences about impacts of policy decisions on adoption dynamics. Building on these inferences, the research aims to contribute to the current understanding about when it is appropriate to use niche management strategies, and how they should be implemented and monitored.

Keywords: e105 competitiveness - innovation - research and development,g203 simulation engineering and modelling,v101 environment and sustainability