Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Computational discovery and design of disease-beating nutrition (Hyperfoods)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-04-01
End date: 2022-06-30
Duration (months): 27.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

With rapidly ageing populations, the world is experiencing an unsustainable healthcare and economic burden from chronic diseases such as cancer, cardiovascular, metabolic and neurodegenerative disorders. Diet and nutritional factors play an essential role in the prevention of these diseases and significantly influence disease outcome in patients during and after therapy. Everyday food ingredients contain multiple drug-like molecules that can potentially prevent or beat diseases. For example, it is estimated that up to half of oncological diseases can be prevented by dietary choices. The wide adoption of tailored health-promoting diets potentially has a revolutionary impact on the population wellbeing and long-term sustainability of the healthcare systems. However, due to an exponentially large number of combinations of the ingredients, their sourcing, processing, preparation, and preservation methods, it is virtually impossible to use traditional experimental approaches to optimise the health-promoting molecular profiles of foods. Hyperfoods will use novel graph-based ML methods to provide the technological capabilities for the computational discovery and design of personalised nutrition. We will explore the commercial opportunities of our technology for currently unmet business needs in global health, in particular cancer treatments.

Keywords: geometric deep learning,graph ml,precision nutrition,digital therapeutic,cancer
REsistive-Switch CompUting bEyond CMOS (RESCUE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2020-07-31
Duration (months): 60.0
Total project cost (EUR): 1998113.12
EU funding (EUR): 1998113.12
Participants: 1
Project status: CLOSED

Digital computers rely today on CMOS (complementary metal-oxide-semiconductor) technology, which improves its performance every generation thanks to the Moore’s law of downscaling. As CMOS transistor size approaches few nm, alternative logic switches with better scaling capability must be identified to prolong Moore’s law beyond CMOS. Among the emerging switching concepts, resistive switching (RS) devices can change their resistance by electrically-induced redox reactions. RS provides the basis for the resistive memory (ReRAM) technology which is currently investigated as future computer memory and storage technology. The objective of this project is to design, develop and demonstrate a novel computing paradigm based on RS devices. The project will pursue this objective at 3 levels of increasing complexity, namely the device fabrication, the design of new logic gates and the demonstration of computing circuits. RS logic will be finally compared to CMOS and other approaches to identify the strength and the potential applications of RS logic in the computing scenario.

Keywords: resistive switching,memristive switching,beyond cmos
Doraya is an innovative catheter device for treating patients resistant to diuretics with Acute Heart Failure (AHF) condition. (Doraya)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Acute Heart Failure (AHF) is a sudden worsening of the signs and symptoms of chronic heart failure, which typically includes difficulty in breathing, leg or feet swelling and fatigue. HF is a growing global problem, affecting millions of people around the world (present in 1%-12% in Europe and the United States. The lifetime risk of developing the disease ranging in between 20%-33%). AHF is the most common cause of hospitalization for patients older than 65 years of age. Over the last 3 decades, the hospitalization rates for patients with AHF has tripled and is expected to increase. An ageing population will increase the prevalence of AHF, which in turn will lead to significant monetary expenses. Fluid decongestion is the key treatment of AHF, where 90% of patients are treated with diuretics. However, 30%-40% of patients are resistant to diuretics. The DorayaTM is the first device to directly create an optimal hemodynamic environment, enabling diuretic efficiency to relieve congestion and restore organ function. The DorayaTM catheter regulates vascular hemodynamics in AHF patients, including those who have developed diuretic resistance. Chronic Heart Failure market is expected to increase from €2.64bn in 2015 to €8.78bn in 2025, which represents a 12.9% of CAGR. Since, AHF market accounts for 75% of the total Chronic Heart Failure market, the total available global market by 2025 is expected to reach €6.59bn. With 30% of patients resistant to diuretics, this represents a huge unmet market that Doraya can service.

Keywords: acute heart failure,heart,catheter
Infinite Protein Self-Assembly in Health and Disease (Agglomerates)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2025-09-30
Duration (months): 78.0
Total project cost (EUR): 2574819.0
EU funding (EUR): 2574819.0
Participants: 1
Project status: SIGNED

Understanding how proteins respond to mutations is of paramount importance to biology and disease. While protein stability and misfolding have been instrumental in rationalizing the impact of mutations, we recently discovered that an alternative route is also frequent, where mutations at the surface of symmetric proteins trigger novel self-interactions that lead to infinite self-assembly. This mechanism can be involved in disease, as in sickle-cell anemia, but may also serve in adaptation. Importantly, it differs fundamentally from aggregation, because misfolding does not drive it. Thus, we term it “agglomeration”. The ease with which agglomeration can occur, even by single point mutations, shifts the paradigm of how quickly new protein assemblies can emerge, both in health and disease. This prompts us to determine the basic principles of protein agglomeration and explore its implications in cell physiology and human disease. We propose an interdisciplinary research program bridging atomic and cellular scales to explore agglomeration in three aims: (i) Map the landscape of protein agglomeration in response to mutation in endogenous yeast proteins; (ii) Characterize how yeast physiology impacts agglomeration by changes in gene expression or cell state, and, conversely, how protein agglomerates impact yeast fitness. (iii) Analyze agglomeration in relation to human disease via two approaches. First, by predicting single nucleotide polymorphisms that trigger agglomeration, prioritizing them using knowledge from Aims 1 & 2, and characterizing them experimentally. Second, by providing a proof-of-concept that agglomeration can be exploited in drug design, whereby drugs induce its formation, like mutations can do. Overall, through this research, we aim to establish agglomeration as a paradigm for protein assembly, with implications for our understanding of evolution, physiology, and disease.

Keywords: structural systems biology,protein evolution,mutations,protein interactions,homo oligomers,homomers
Innovative approach for the digital ceramic tile glazing process, using a continuous in-line glazer (Glazetile)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The ceramic tile industry is a critical industry within the EU, accounting for over 200,000 jobs in the EU-27, with an annual production value of €28 bn. World-leading companies in this sector are headquartered in the EU. According to Grand View Research, the Ceramic Tiles Market size worth is estimated to reach a value of €151.18bn by 2024. The main challenge faced by the ceramic tile industry is of long processing times – glazing is one main processing stages that is also slow. This process is currently carried out through highly unsustainable screen printing and spraying technologies that uses organic solvents and experience significant glaze and solvent loss. These technologies are slow and pose serious health threat to ceramic tile workers due to continuously exposure to high levels of toxic organic solvent and Silica. Although inkjet printing for the decoration of ceramic tiles is a mature technology and several machines are currently commercially available, there is currently no digital machine able to apply and dose the ceramic glazes on the tiles in a continuous in-line process. Further spray technologies available use glazes with of <40 microns and mixtures of water and organic solvents in different ratios as suspension media, and thus use a lot of energy in glaze milling and extractors to maintain acceptable level of volatiles in the atmosphere. The Glazetile project seeks to develop a new family of digital machines (named DigiGlaze and DigiGraphic) to achieve in-line deposition of glass/ceramic glazes using water based suspensions with particle size of < 50 microns. Our water based suspensions eliminate the vapour origins from organic solvents and create a healthier and safer working environment. In addition to this, the glazes deposed with our technology have a better tactile impression when the tile is touched. Glazetile thus reduces the cost of glazing and decorating, producing a higher quality end-product.

Keywords: continuous process,in line,digital machines,glazes,glazing,ceramic tile production
THE RISE OF IRON TECHNOLOGY IN PRE-ROMAN IBERIA: A LARGE-SCALE AND MULTIDISCIPLINARY APPROACH (IBERIRON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-15
End date: 2020-11-14
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The IBERIRON project is aimed at improving our understanding of the origins, development and transmission of iron technology in the Western Mediterranean and its socio-cultural ramifications. The Iberian Peninsula is chosen as a representative framework because of the interactions it features between local technological developments and external influences (Phoenician and Central European). For this purpose, it is essential to characterize the iron technology in the Iberian Peninsula since the end of the Bronze Age to the arrival of the Romans (first quarter of the 1st millennium BCE-3rd c. BCE), which has not been properly done yet. This project is going to design and implement a strict methodology for gathering high quality technological data from selected iron objects from Spanish and Portuguese sites in museum collections. These protocols will include a broad range of analytical methods (metallography, spectroscopy, SEM, EPMA, etc.) which are going to be used to characterize the technological details of the objects, introducing also Neutron Diffraction analyses in order to study non-destructively highly significant specimens never analysed before. A data model will be proposed and the results integrated in it, leading to an open access database that can be developed into an interoperable Spatial Data Infrastructure (SDI). The database will be subjected to statistical analyses and data-processing algorithms to obtain patterns that provide information on the generation, transmission and exchange of iron technology. The results will be finally integrated in a wider background that will surpass the boundaries of the technological framework and offer insight into broader social, cultural, archaeological and historical aspects. This future SDI is also going to complement ongoing similar projects and research on Cu-based metallurgy of the Iberian Peninsula that have been going on for a long time with standing success.

Keywords: ancient metallurgy,technological knowledge,cultural exchange,spatial data infrastructures,digital,humanities
Nuclear Magnetic resonance auGmented by Nitrogen-vacancy centres and Field versatility (MaGNiFi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Increasing the sensitivity and resolution of nuclear magnetic resonance (NMR) is of fundamental importance in medicine, chemistry, and physics. Diamonds with nitrogen-vacancy centres are promising vehicles to provide NMR with unprecedented sensing capabilities at room temperature; however, hitherto employed nitrogen-vacancy NMR systems exhibit sensitivities orders of magnitude away from theoretical limits and impose impractical experimental conditions. This limitation is largely owing to their limited capability of generating a rapidly changing magnetic field as needed for optimal operation. This action aims to develop a novel desktop NMR device that boosts the sensitivity and resolution of nitrogen-vacancy based NMR by being capable of switching the field strength and direction orders of magnitude faster than existing setups and without needing to shuttle the sample. Among others, such disruptive technology could allow detecting diseases much earlier than ever and gaining insight on the functioning of cells at individual molecular level. Importantly, this device would complement the benefits of existing NMR systems at a fraction of their cost and size. Given the overarching use of NMR in areas such as health, environment and food, this project can have a broad positive impact in the European Research Area. Having developed a number of novel NMR devices, the experience of the fellow will be of great value and complements with that of Host and Partner supervisors, which are top-flight experts on quantum photonics for nanoparticles and spin polarisation dynamics respectively. This multidisciplinary nature of the project would provide fertile grounds for extensive knowledge transfer between all the actors. Importantly, beyond broadening the competences of the fellow in the fast-growing field of quantum sensing, proposed outreach, supervision, and complimentary course activities form a comprehensive training package for the fellow to reach professional maturity.

Keywords: nuclear magnetic resonance,magnetic resonance imaging,dynamic nuclear polarization
The Integrated Initiative of European Laser Research Infrastructures (LASERLAB-EUROPE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Belgium,Switzerland,Hungary,Lithuania,Poland,Sweden,Slovakia,Greece,Croatia,Romania,Latvia,France,France,France,France,Czechia,Netherlands,Netherlands,United Kingdom,Portugal,United Kingdom,Portugal
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2019-1, 2019)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 10000000.0
EU funding (EUR): 10000000.0
Participants: 36
Project status: SIGNED

LASERLAB-EUROPE is the European consortium of major national laser research infrastructures, covering advanced laser science and applications in most domains of research and technology, with particular emphasis on areas with high industrial and social impact, such as bio- and nanophotonics, material analyses, biology and medicine. Recently the field of advanced lasers has experienced remarkable advances and breakthroughs in laser technologies and novel applications. Laser technology is a key innovation driver for highly varied applications and products in many areas of modern society, thereby substantially contributing to economic growth. Through its strategic approach, LASERLAB-EUROPE aims to strengthen Europe’s leading position and competitiveness in this key area. It facilitates the coordination of laser research activities within the European Research Area by integrating major facilities in most European member states with a long-term perspective and providing concerted and efficient services to researchers in science and industry. The main objectives of LASERLAB-EUROPE are to: • promote, in a coordinated way and on a European scale, the use of advanced lasers and laser-based technologies for research and innovation, • serve a cross-disciplinary user community, from academia as well as from industry, by providing access to a comprehensive set of advanced key laser research installations, • increase the European basis of human resources in the field of lasers by training new users, including users in new domains of science and technology and from geographical regions of Europe where laser user communities are still less developed, • improve human and technical resources through technology exchange and sharing of expertise among laser experts and operators across Europe, and through coordinated Joint Research Activities enabling world-class research, innovations and applications beyond the present state-of-the-art.

Keywords: lasers,physical sciences,optical technologies,photonics,materials research,biomedical optics,bio imaging,high field science,laser spectroscopy,laser applications
sUstainable PLastIcs for the Food and drink packaging indusTry (UPLIFT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Austria,Germany,Germany,Germany,Spain,Spain,Sweden,Belgium,Croatia,Denmark,Denmark
Call: Upcycling Bio Plastics of food and drinks packaging (RIA) (H2020-NMBP-TR-IND-2020-twostage, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 7640653.75
EU funding (EUR): 7517180.75
Participants: 15
Project status: SIGNED

Recycling facilities are currently struggling when dealing with challenging plastic multi-layers, blends, and additives. Consequently, packaging plastics are mostly landfilled, incinerated or spilled into the environment. The concept of UPLIFT is to introduce biological depolymerization technology as an addition and integration to established recycling practices, by converting persistent plastic waste into more easily recyclable and/or degradable polymers. The project will start by analyzing the value-chains of the future to match and exploit the potential of microbe-and enzyme technology to effectively depolymerize the EoL plastic into monomers. Overall, the project aims at engineering towards greater scale and efficiency. Moreover, in order to contribute to further innovation, UPLIFT will also make use of an advanced high-throughput screening platform to further explore the potential of new and more efficient biocatalysts, among bacteria, yeasts and fungi. Synergies between genetic and protein engineering, as well as eco-engineering of microbial mixed consortia will be under Uplift’s scope. Furthermore, the knowledge of bio-depolymerization will be strategically applied for the eco-design and development of renewable and easy-recyclable polymers, thus making plastic packaging an available feedstock for the circular economy. Introducing biological depolymerization to current recycling practices will increase the capability of dealing with large amounts of currently non-recycled plastics. By doing so, UPLIFT will contribute and facilitate the transition to more efficient recycling facilities, thus paving the way to a sustainable plastic system.

Keywords: upcycling,plastic,eco design,enzymes,polymers,food and drink packaging