Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multi-disciplinary risk management for stable, safe, and sustainable offshore wind-powered hydrogen production (WINDHY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway,Egypt,Australia,Malaysia,Japan,Colombia,Portugal,Denmark,Spain,United Kingdom,United States,China,Thailand
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 1016600.0
EU funding (EUR): 1016600.0
Participants: 13
Project status: SIGNED

The WINDHY project focuses on the novel production phase of offshore wind-powered green hydrogen as a new energy solution, where the main tasks include obtaining electricity from offshore wind turbines, utilizing electrolysis to derive hydrogen from water, transferring hydrogen to a certain energy carrier, and injecting the hydrogen carrier into a designated transportation mechanism. Many new technologies are under consideration and development for this process, and each of them has own advantages and limitations, as well as varying risks to operators, communities, and the environment. The WINDHY project aims to utilize cross-industry knowledge worldwide and global evidence to understand the risky issues that threaten the stability, safety, and sustainability of offshore wind-powered hydrogen production, and integrate multi-disciplinary expertise to control and mitigate risks of the new process and value chain of offshore wind-powered hydrogen production. The WINDHY project builds a multidisciplinary consortium, with five MS/AC partners, and eight TC partners from 13 countries in all continents. It designs a staff exchange programme with 263 person-months for secondments realized in six work-packages. Through the secondments, and diverse networking activities, the project is expected to conduct a global survey in all participating countries to understand public perceptions and concerns on risky issues, interconnect knowledge about accidents in isolated databases in multiple sectors and regions, evaluates different aspects of social-, economic-, and environmental sustainability of new technologies, and develop a risk management framework with digital supporting tool for the new production equipment and process. The project follows the open science policy with a dedicated data management plan, and aims to develop skills of participating researchers, and improve R&I potential of Europe in offshore renewable energy.

Keywords: wind powered hydrogen production,risk perception,public acceptance,emerging technology,risk management,multi objective decision making,digitalisation,natural disaster triggered accident
Cardiac regeneration by mRNA-triggered proliferation of cardiomyocytes (REGeRNA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: France,Netherlands,Poland,Belgium,Switzerland
Call: Next generation advanced therapies to treat highly prevalent and high burden diseases with unmet medical needs (HORIZON-HLTH-2021-TOOL-06, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 5010638.75
EU funding (EUR): 5010638.0
Participants: 6
Project status: SIGNED

Heart failure (HF) is a major health problem worldwide because of the high number of patients and the related costs. Current treatments are not consistently efficacious and fail to address the major underlying cause of HF: the massive loss of cardiomyocytes in damaged regions. REGeRNA has been designed to address this issue by leveraging advances in synthetic mRNAs and their lipid nanoparticle (LNP)-based carriers to generate a construct able to reactivate mechanisms mediating cardiomyocyte proliferation in development but which are shut-down shortly after birth. REGeRNA is organised in 6 work packages that follow a roadmap towards endogenous heart repair. The program starts tailoring various human assays and in vitro models such that they can reliably document cardiomyocyte proliferation. These will then be used for screening pathways thought to be involved in cardiomyocyte division, among which Hippo is our primary candidate. mRNA(s) encoding the relevant proteins will be subsequently synthesised and engineered such that their expression is restricted to cardiomyocytes and no stromal cell expansion occurs. An LNP formulation will then be developed for incorporation of the synthesized mRNA(s) and optimized for cardiomyocyte-specific delivery. Subsequently, we will test the mRNA+LNP construct in our human model systems and in mouse models of myocardial ischaemia/reperfusion including transgenic strains that allow unequivocal assessment of cardiomyocyte division in vivo. We will then construct a GMP production line for the mRNA-LNP encapsulation technology to generate pilot batches for pig studies entailing catheter-based endomyocardial injection of the construct in a similar myocardial ischaemia/reperfusion model. The final work package will be responsible for the management and coordination of the project, dissemination, intellectual property management and exploitation of REGeRNA results. This program is framed from the onset to lead to a phase 1 trial at completion

Keywords: heart failure,cardiac regeneration,cardiomyocyte proliferation,mrna,lipid nanoparticles,translational research,large animal models,gmp production line
Holographic nanoscale imaging via femtosecond structured illumination (HOLOFAST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1499838.0
EU funding (EUR): 1499838.0
Participants: 1
Project status: SIGNED

Solution-processed organic and hybrid materials have immense promise for low-cost photovoltaic devices. Their intrinsically heterogeneous morphology directly impacts the photophysical processes that happen over multiple timescales down to femtoseconds and which ultimately define functionality, such as carrier diffusion, charge separation and recombination. Currently, experimental techniques that can simultaneously study the nanoscale morphology and the ultrafast photophysics are limited. Ultrafast microscopes are restricted to single point or very small fields of view, lacking the large sample area coverage needed to place observations in their proper statistical context. Moreover, they are generally incompatible with super-resolution imaging, preventing the required nanoscale spatial resolution from being achieved. Recently, I introduced a widefield transient holographic microscope using off-axis holography that has shot-noise limited performance and can image large sample areas. Importantly, this approach is compatible with nonlinear structured illumination, a widefield super-resolution technique based on combining a spatially structured illumination pattern and a nonlinear sample response, with the spatial resolution being only limited by how many nonlinear terms can be acquired. In HOLOFAST, my team and I will combine the new ultrafast holographic microscope with nonlinear structured illumination to bring unprecedented photophysical knowledge of organic photovoltaic materials, with temporal resolution down to 10 femtoseconds, spatial resolution down to 50 nm while simultaneously imaging ~100 micron areas, correlating morphology with excited state dynamics. This will enable us to finally reveal the heterogeneity of charge separation and extraction processes over large sample areas. HOLOFAST will create a photophysical and morphological database that will be valuable to understand and solve the problems that currently limit device efficiencies and lifetimes.

Keywords: ultrafast spectroscopy,hot carrier transport,super resolution microscopy,ultrafast microscopy
Interplay of CMV with cellular pathways, states and cell types (CMVinterplay)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The herpesvirus human cytomegalovirus (HCMV), the largest known human virus, is a ubiquitous pathogen that infects the majority of the world's population. Although subclinical in most healthy individuals, HCMV can lead to a severe congenital disease, as well as morbidity and mortality in immunocompromised adults. Despite the high prevalence and pathogenicity of HCMV, numerous fundamental questions about this pathogen remain open. We still do not know what many of its viral proteins do and how they modulate cellular processes, we do not understand the determinants that govern dependencies and vulnerabilities of infection in different cell types, and we are missing tools that facilitate molecular dissection of HCMV in relevant infection models. In this proposal, we plan to develop and apply unique tool sets to uncover the host pathways and factors that orchestrate HCMV life cycle in different cell types and in higher complexity infection models. We propose to combine state-of-the-art high-throughput tools with mechanistic studies to comprehensively characterize how HCMV proteins perturb central host cellular processes (aim 1), identify HCMV common and cell-specific host dependencies and vulnerabilities in different cell types (aim 2) and develop an advanced platform for probing CMV dependencies in organoid and organism infection models (aim 3). The knowledge generated from these objectives will provide a comprehensive depiction of the interplay of HCMV with its host and could help expand our therapeutic options. More broadly, with its comprehensive and complementary approaches, our work will provide a paradigm for understanding complex host-pathogen interactions.

Keywords: cytomegalovirus,viral host interaction,genetic screen,system virology,herpesvirus
A spec-to-sign-off smart RISC-V FV app using AI/ML (iSecureFV)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1499064.0
EU funding (EUR): 1499064.0
Participants: 1
Project status: SIGNED

Axiomise will develop iSecureFV, an app to automatically parse the architectural and micro-architectural specifications of RISC-V processor implementations and generate fully executable formal test benches capturing combinatorial and temporal logic. It provides an end-to-end (specification to sign-off) push-button solution. iSecureFV will be powered by Axiomise's in-house proof engineering, abstraction technology and formalISA app, producing a comprehensive debug report and a six-dimensional coverage dashboard with high-level safety and security assurance.

Keywords: formal verification,riscv,security,safety,ai,machine learning,abstraction
Petrification of ius commune through printed paratexts (PetrIUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Between the 1460s and 1620s, printed editions of canon and civil law texts witnessed a constant development of marginal paratexts, such as glosses, summaries, cases or commentaries. They were added to authoritative legal sources because the printers were interested in improving the quality and attractiveness of new source editions. They often hired legal experts who offered them new tools, resources, and ideas. These were incorporated into printed books using new printing techniques. In consequence, the dynamic between improved new editions and advances in printing enterprise fueled the ongoing development of printed legal books. Various questions concerning the origin, transmission, and influence of paratexts are embedded in the interplay between sources and marginalia, manuscripts and printing, editors and printers, and books and their readers. PetrIUS has an innovative approach for shifting the focus from source (text) to marginalia (paratexts). PetrIUS aims to examine how print and its evolution helped to petrify – that is, consolidate – landmark achievements of late medieval ius commune. This is done by enabling some doctrinal accounts to be transferred into marginalia of source editions. The novelty brought about by print affected legal science and communication. PetrIUS will acknowledge how legal experts employed novel technical tools to transfer the heritage of medieval law into early modern source editions and how these processes affected patterns of scientific work and the transfer of knowledge in academia. To do so, PetrIUS will implement typical legal and book history tools as well as natural language processing techniques. The latter enables detailed comparisons between paratexts’ printed editions and their reception in the scholarly literature. The research will conclude with a legal theoretical study that assesses the early modern significance of paratexts by treating them as the media of law, that is, the means of legal communication.

Keywords: legal history,early modern history of canon and roman law,book history,paratexts,marginalia,natural language processing techniques in humanities
SKILLS FOR LABOUR MARKETS IN THE GREEN AND DIGITAL TRANSITION (SkiLMeeT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Poland,Luxembourg,Italy,Bulgaria
Call: Tackling European skills and labour shortages (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2994866.25
EU funding (EUR): 2994866.25
Participants: 8
Project status: SIGNED

The project SkiLMeeT (Skills for labour markets in the digital and green transition) has three main objectives: 1) generate data and indicators which quantify the extent of labour and skills shortages and mismatch in Europe; 2) explore the drivers of these gaps and shortages, with a focus on the digital and green transitions; 3) analyse and identify pathways to reduce skill gaps and shortages. SkiLMeeT advances the knowledge how the work programme’s main goals can be achieved: to equip the workforce with the demanded skills, to encourage successfully the necessary reskilling and upskilling of the workforce and ultimately to realise the full potential of the digital and green transitions for Europe as a whole. To achieve these aims, SkiLMeeT builds on an inter- and transdisciplinary approach bringing together quantitative and qualitative methods. The combination of in-depth case studies and broad analyses of European economies using a rich variety of data sources ranging from survey and administrative data to big data provides highly valuable complementary insights into the nature of shortages, their drivers and pathways out. The indicators created are transparent and easily accessible. The analyses of drivers and pathways are conducted both for all European countries and for particularly relevant example countries. To validate the quantitative analyses, to explore mechanisms and to identify particularly promising pathways, we engage in extensive consultations and set up feedback loops with the research community, especially with relevant international and national research initiatives, and with stakeholders. The stakeholder consultations help to develop concrete policy proposals aimed at a thriving economy and an inclusive society. To maximise SkilMeeT’s impact, we disseminate the project’s indicators and insights, as well as concrete policy proposals to policymakers, stakeholders and the public.

Keywords: skill transferability worker flows human capital upskilling mismatch technology digital transformation green transformation decarbonization labour market policy big data
Genuine Quantum Algorithms Inspired by Thermodynamics and Natural Phenomena (QuanThermal)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Hungary
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1470693.0
EU funding (EUR): 1470693.0
Participants: 1
Project status: SIGNED

As low-noise medium-scale quantum devices are on the horizon, it is becoming increasingly important to find useful quantum algorithms that can be run on such devices. However, existing quantum algorithms typically only offer an advantage compared to advanced classical computers when run on large-scale quantum devices for rather long running times, urging us to find more effective quantum algorithms. This project aims to design new efficient Nature-inspired quantum algorithms and find new applications and use cases, through quantum generalisations of the Metropolis algorithm and Glauber dynamics, whose classical counterparts were also distilled from deeper understanding of physical models and thermodynamical processes, but turned out to be foundational in computer science through applications to a wide range of problems outside their original scope. The primary focus is on quantum algorithms related to open quantum systems and thermalisation. Such algorithms can be described by Quantum Markov Chains (QMC), which unify the powerful paradigms of classical randomized algorithms and traditional coherent quantum algorithms. Due to their rich, complex structure such processes have proven to be hard to construct and analyse. The PI's recent breakthroughs in designing detailed-balanced QMCs opened new ground in quantum algorithms design, and the PI intends to explore and exploit the resulting QMC algorithms and adapt them to the requirements of early quantum devices. The PI's interdisciplinary approach already led to the successful translation of the physics inspired "Quantum Signal Processing" protocol to a major unification of various quantum algorithms via "Quantum Singular Value Transformation" (QSVT) (which has been presented at STOC'19 and cited 750 times since). Further building on physics intuition and CS insights, this project aims to pave the way of QMC-based algorithms for advancements in quantum simulation, optimization and information processing.

Keywords: quantum algorithms,quantum markov chains,metropolis algorithm,quantum channels
StarDance: the non-canonical evolution of stars in clusters (StarDance)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 2492250.0
EU funding (EUR): 2492250.0
Participants: 1
Project status: SIGNED

Thanks to their ubiquity, brightness, and the fact that they are made of stars with similar properties, star clusters have been used as astrophysical laboratories or test particles in an impressive range of research domains. However, we still do not understand fundamental details of their formation and evolution. In spite of recent technological progress, a list of unsolved problems and apparently isolated mysteries has been accumulating over time, some standing since decades. Among them, the existence of multiple stellar populations in globular clusters, with different chemistry, has challenged generations of researchers. They are not the result of classical galactic chemical evolution, mostly mediated by supernovae, and they jeopardize the use of clusters as simple stellar population templates for extragalactic studies. Given the mounting problems faced by the most favored scenarios to explain multiple populations, I think it is now time to revisit the foundations of our current thinking. New results by my team and by others show that: (i) the peculiarities in the chemistry of multiple populations are not limited to the oldest globular clusters; (ii) they can be transient in the evolution of individual cluster stars; and most importantly (iii) binary interactions and fast stellar rotation cannot be neglected in the study of star clusters and do have the capability to produce the observed chemistry. With StarDance I will test a very different scenario, based on a new hypothesis: that multiple stellar populations and five other non-canonical stellar populations (extreme horizontal branch stars and hot sub-dwarfs; extended main sequence turn-offs; red stragglers and sub-subgiants; lithium rich- stars; and blue stragglers) are caused by the interplay between stellar rotation and binary interactions, that are greatly enhanced in the special environment of star cluster, with spectacular results.

Keywords: techniques spectroscopic surveys stars abundances stars binaries stars rotation galaxy globular clusters galaxy open clusters and associations galaxy abundances