Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovation test bed for development and production of nanomaterials for lightweight embedded electronics (LEE-BED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Austria,Spain,Spain,Spain,Germany,Spain,Sweden,France,Netherlands,Netherlands,Netherlands,United Kingdom,Denmark,Denmark
Call: Open Innovation Test Beds for Lightweight, nano-enabled multifunctional composite materials and components (IA) (H2020-NMBP-HUBS-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 11463716.25
EU funding (EUR): 10696766.25
Participants: 20
Project status: SIGNED

LEE-BED brings together world leading European RTOs to establish an Open Innovation Test Bed to de-risk and accelerate the development and manufacturing of nanomaterials and lightweight embedded electronics for the benefit of European industry. Access to such a Test Bed will help establish the industrial eco-systems, R&D investments and new supply chains to support market entry as well as providing a global competitive advantage, leading to growth and job creation. For Europe to be more competitive compared to the US and Asia, digitalisation of both the development and manufacturing of functional nanomaterials and printed components needs to be established, as well as addressing cost, productivity and capacity. The digitalisation of the European production industry (industry 4.0) through digital based production technologies, such as ink-jet printing, additive manufacturing, robotically assisted in-mould labelling, laser processing, stereo lithography, etc., requires functional nanomaterials and formulations and is a major bottleneck due to high prices and limited volume production. LEE-BED will address these challenges by building European infrastructure for rapid development and pilot production of nanomaterial, inks, adhesives and composites as well as digital based pilot production lines. LEE-BED will unify the entire value chain from raw materials to embedded electrical components, providing tailored solutions for European entrepreneurs, start-ups, SMEs and large enterprises, with the main objective of going from concept to prototype within six months. Unique to LEE-BED will be the development of tailored services, including technical, business, patent mapping, safety and life-cycle analysis modelling. LEE-BED will also provide funding services for LEE-BED access to SMEs and post-project capital. LEE-BED will guide European industry towards sustainable implementation of innovative technologies, making them stronger and more globally competitive.

Keywords: printed electronics,embedded electronics,conductive nano inks and composites,dielectric nano inks and composites,rapid prototyping,digital pilot production lines
SITless: Exercise Referral Schemes enhanced by Self-Management Strategies to battle sedentary behaviour (SITless)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,France,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Comparing the effectiveness of existing healthcare interventions in the elderly (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2020-09-30
Duration (months): 65.0
Total project cost (EUR): 4547560.0
EU funding (EUR): 4547560.0
Participants: 8
Project status: CLOSED

The increase of the elderly population leads to increased prevalence of frailty, risk for poor health outcomes, and related health and social care costs. Lack of physical activity (PA) and established sedentary behaviours (SB) constitute an additional burden, as they are related to progression of chronic disease and disabling conditions. An existing initiative to battle SB and insufficient PA levels are exercise referral schemes (ERS) implemented in primary care, where insufficiently active individuals are referred to a third party service (sports centre or leisure facility) that prescribes and monitors an exercise programme tailored to the patients’ needs. ERS had shown improvements in PA in the short-term, but may have limited power to change SB and produce long-term effects. Thus, ERS might be enhanced by self-management strategies (SMS) to promote behavioural change. Such strategies based on social cognitive theory have been shown to increase self-confidence, power to act, and involvement in exercise. In a first stage, a systematic review, focus groups and a feasibility study will be conducted. Then, a three-armed pragmatic randomized controlled trial (RCT) will assess the long-term effectiveness of a complex intervention on sedentary behaviour (SB) in an elderly population, based on existing ERS enhanced by self-management strategies (SMS). It will be compared to ERS alone and to general recommendations. The RCT will include 1138 subjects and will have a follow up of 18 months. The effect on SB will be measured as activity daily counts per minute and physical function. Secondary outcomes will include: healthcare use and costs, self-rated health and quality of life, mortality, morbidity, disability, institutionalization, mental health, social capital, sarcopenia and safety parameters. SITless will assess policy makers in deciding how or whether ERS should be further implemented or restructured in order to increase its adherence, efficacy and cost-effectiveness.

Keywords: physical activity,sedentary behaviour,intervention,behavioural intervention,cost effectiveness analysis,physical function,elderly,exercise referral schemes,randomized control trial
Soil MIcrobial responses to land use and climatic changes in the Light of Evolution (SMILE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1688250.0
EU funding (EUR): 1688250.0
Participants: 1
Project status: SIGNED

Quoting T. Dobzhansky, “nothing in biology makes sense except in the light of evolution”. This idea could shed new light on how soil microbes access, transform, store, and release their most important resources – carbon and nutrients. We know that these microbial processes have global-scale impacts, including climate regulation and provision of nutrients to plants, but how microbes respond to changes in resources remains challenging to understand and quantify with models. In fact, current models cannot reliably reproduce carbon and nutrient storage and fluxes when soils are disturbed by land use changes or environmental fluctuations (especially of soil moisture). To address these urgent challenges and improve predictability of carbon and nutrient cycling, I propose a novel theory based on the premise that microbial use of soil resources is optimized by natural selection. This approach will provide a holistic explanation of microbial processes and yield models that are more reliable than traditional ones because they account for microbial adaptation. After testing this optimality hypothesis, I will answer the broader and globally relevant question – are land use and climatic changes increasing retention or loss of soil carbon and nutrients? The project will achieve four objectives: 1) Determine the optimal strategies of resource use by soil microbes 2) Fill knowledge gaps on microbial processes by constructing new databases 3) Test the optimality theory using the new databases 4) Integrate the optimality theory into a land surface model to scale up results and assess impacts of land use and climatic (specifically hydrologic) changes on carbon and nutrient storage and fluxes These theoretical advances will spur a new generation of soil models that translate the outcomes of natural selection into reliable predictions of land use and climate change effects on global ecosystems.

Keywords: carbon,nitrogen,soil,modelling,microbial biomass,soil moisture,functional trait
High efficient Particulate free Gasoline Engines (UPGRADE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Italy,Italy,Austria,Germany,Germany,Germany,Italy,Greece,Sweden,France,France,France,United Kingdom,United Kingdom
Call: Technologies for low emission light duty powertrains (H2020-GV-2016-INEA, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 8119766.81
EU funding (EUR): 8119766.8100000005
Participants: 15
Project status: CLOSED

The UPGRADE project aims to support the transition to a high efficient, cleaner and affordable powertrain technology systems, based on Spark Ignited GDI (Gasoline Direct Injection) approach, suitable for future Light Duty applications. The project also includes a deep analysis of the phenomenon of the formation of the nanoparticles in relationship to the engine design and its operating conditions and, with regard to the after-treatment solutions, the study and development of new Gasoline Particulate Filter (GPF) technologies. To increase the engine efficiency under Real Driving conditions, the following steps will be carried out: - address stoichiometric combustion approach on the “small” size engine and lean-burn combustion approach on the “medium” size one - study and develop the best combinations of technologies, including advanced VVA/VVT capabilities, advanced boosting system (including electrically assisted booster operations), EGR (Exhaust Gas Recirculation) and thermal management systems - Explore and implement advanced fuel injection (direct) and ignition system supported by new dedicated control strategies that will be integrated in the ECU (Engine Control Unit) software. In order to demonstrate the call overall targets (15% improvement on CO2 emissions based on the WLTP cycle and compliancy with post Euro 6 RDE standards) the project will see the realization of two full demonstrator vehicles: one B-segment vehicle, equipped with the small downsized stoichiometric engine, and one D/E vehicle equipped with the medium size lean-burn engine. The vehicle will be fully calibrated and assessed by independent testing, according to on road test procedures, using the available best representative PEMS (Portable Emission Measurement System) technology and considering also PN measurement below 23 nm diameter.

Keywords: efficient particulate free gasoline engine
Characterizing the roles of transcription factor isoforms in rewiring gene regulatory networks during adipogenesis (FatTFIso)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Metabolism-related disorders like obesity are on the rise worldwide, posing a major global disease burden. Fat tissue is a key site of metabolic regulation, and understanding how adipocytes develop is an important step in designing effective treatment or intervention strategies. This proposal aims to understand the gene regulatory network (GRN) underlying adipogenesis and to which extent this GRN is modulated by transcription factor (TF) isoforms. Adipogenesis is regulated by a network of successively activated TFs. Many of these TFs have multiple isoforms, a handful of which (e.g. PPARγ) are known to function divergently from their reference forms. Thus, this project will investigate the potentially key role of TF isoforms in shaping the adipogenic program and its robustness. In Objective 1, I will combine computational analysis with a novel microfluidic in vitro TF–DNA binding assay to characterize the DNA binding specificities of TF isoforms with the goal of identifying those that have the potential to rewire GRNs. In Objective 2, I will screen for TF isoforms that modulate the process of adipogenesis, using a novel droplet-based single-cell technology to assay how adipocyte differentiation changes in response to TF isoform overexpression. ChIP-seq and single-cell transcriptome profiling, combined with powerful computational analysis, will elucidate the molecular basis of these changes in relation to GRNs. Findings from this project will improve our understanding of transcriptional mechanisms in adipogenesis. Furthermore, results will have broad implications for the role of TF isoforms in gene regulation, highlighting the complexity of gene regulatory mechanisms that underlie cell and tissue specificity.

Keywords: transcription factor,alternative isoform,adipogenesis,gene regulatory network,tf dna interaction,single cell
Molecule design for next generation solar cells using machine learning approaches trained on large scale screening databases (MolDesign)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United States,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2022-01-01
Duration (months): 33.0
Total project cost (EUR): 208963.5
EU funding (EUR): 208963.5
Participants: 3
Project status: CLOSED

Research in organic electronics has already generated important applications, such organic light emitting diodes (OLEDs) in mobile displays that are already indispensable in our everyday life. Other applications, such as large scale displays and lighting, lightweight and flexible organic photovoltaics, carbon-based electronic paper, organic sensors and RFID tags, are under intense investigation. The multifunctional character of these applications poses enormous challenges for the development of novel materials, which are hard to meet with the present day trial-and-error strategies. The MolDesign project thus aims at computational material design by combining accurate but involved materials simulation methods with inexpensive novel machine learning methods to enable large scale guided materials screening. These methods will be used to improve small-molecule organic semiconductors, which are used as absorber materials in vapor-deposited organic solar cells. While some materials of this class are almost at the photovoltaics market, there is much room for improvement regarding properties such as charge carrier mobility as well as the integration of organic material into completely new applications, such as hole transport materials in highly promising perovskite solar cells.

Keywords: organic electronics
Integrating empirical and modelling research to assess climate change impacts on demersal fish communities (DemFish)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United States,Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 286921.92
EU funding (EUR): 286921.92
Participants: 2
Project status: SIGNED

Demersal, bottom-living, fish are a globally important marine resource accounting for 35% of global fisheries catches. Future projections suggest that demersal fish community biomass will decline in most continental shelves due to climate change. Yet, these predictions have not been validated, neither across marine regions nor with shifting climatic conditions, limiting their practical use in fisheries management. My goal is to therefore integrate empirical and theoretical research and assess climate change impacts on demersal fish communities across North Atlantic shelf ecosystems. The project has three objectives (i) examine cross-regional variation and temporal change in demersal biomass and fisheries catches (ii) validate and improve a fish community model with the results of objective 1, and (iii) project how demersal fish communities will respond to future changes in temperature and resources. The project will complement my skills in theoretical modelling with training in the empirical analysis of demersal fish community data. I will be supervised by Prof. Jeremy Collie from Rhode Island University US, who is strongly qualified to supervise a project seeking to bring together these two fields. I will analyze statistical models to determine variation in demersal biomass and catches in space and time. I will validate and improve a recently developed fish community model with the obtained empirical estimates. Lastly, I will use the validated model to project changes in demersal fish community biomass and production. The project is complemented with a secondment with training in fisheries economics to assess the economic impacts of my climate change projections. The project will move from theory to nature and through time, and this integrative framework will not only provide novel insights in predicting the fish productive capacity of ecosystems, but it will also set new standards on large-scale climate change projections of fish communities.

Keywords: trait based ecology,climate projections of fish,food webs
Multidisciplinary Institute for Ageing (MIA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Netherlands,United Kingdom,Portugal
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 499232.75
EU funding (EUR): 499232.75
Participants: 5
Project status: CLOSED

This project describes a teaming partnership between the University of Coimbra (UC) (partner in a low-performing country) and the University of Newcastle (UNEW) (partner in a high-performing country) to create, in Coimbra, a new Centre of Excellence in Ageing Research - the Coimbra Multidisciplinary Institute of Ageing (MIA). This flagship project for the Centro Region of Portugal is aligned with the regional RIS3 and will be coordinated by the regional authority CCDRC (strategic coordinator) and by UC (operational coordinator). The Newcastle University Institute for Ageing (NUIA) is one of the largest and longest established institutions in translational ageing research worldwide. In this teaming project, NUIA is supported by two further world-leading centres in translational ageing research; the University Medical Center Groningen (UMCG) and the Mayo Clinic Robert and Arlene Kogod Center on Aging. European Member states are committed to increase human healthy life expectancy by two years on average by 2020. Present increases in healthy life expectancy are largely due to increasing differences in ageing rates between member states, regions, communities and individuals. This massively worsens socioeconomic inequalities. Recent progress in understanding the mechanisms of ageing suggests that social, lifestyle, nutritional and pharmaceutical interventions can, effectively, reduce these differences by targeting the faster ageing members of the population. The overall objective of the new Centre for Excellence is to improve health and wellbeing of an ageing population. It will gain a forefront position in ageing research and develop, validate and deliver interventions that can improve human healthy life expectancy. It will train young researchers and engage the public in support and implementation of innovative good practices. MIA will be integrated into the Ageing@Coimbra Vitality Campus, a European Innovation Partnership on Active and Healthy Ageing Reference Site.

Keywords: centre of excellence,ageing research,multidisciplinary,health and wellbeing,smart specialisation strategy,research and innovation,regional cluster,vitality campus
Determining the instructive tissue signals and the master transcription factors driving Kupffer cell differentiation (KupfferCellNiche)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-07-01
End date: 2022-12-31
Duration (months): 66.0
Total project cost (EUR): 1996705.0
EU funding (EUR): 1996705.0
Participants: 1
Project status: CLOSED

We have recently shown that contrary to common hypotheses, circulating monocytes can efficiently differentiate into Kupffer cells (KCs), the liver-resident macrophages. Using self-generated knock-in mice that allow specific KC depletion, we found that monocytes colonize the KC niche in a single wave upon KC depletion and rapidly differentiate into self-maintaining KCs that are transcriptionally and functionally identical to their embryonic counterparts. This implies that: (i) access to the KC niche is tightly regulated, ensuring that monocytes do not differentiate into KCs when the KC niche is full but differentiate very efficiently into KCs upon temporary niche availability, and (ii) imprinting by the KC niche is the dominant factor conferring KC identity. Understanding which cells represent the macrophage niche, which signals produced by these cells imprint the tissue-specific macrophage gene expression profile and through which transcription factors (TxFs) this is mediated is emerging as the next challenge in the field. We here propose an original strategy combining state-of-the-art in silico approaches and unique in vivo transgenic mouse models to tackle this challenge specifically for KCs, the most abundant macrophage in the body. We hypothesize that the liver sinusoidal endothelial cell (LSEC) to which the KC is attached represents the most likely candidate to sense KC loss, recruit new monocytes and drive their differentiation into KCs. Thus, this proposal aims to: (I) determine the TxFs through which the niche imprints KC identity, (II) map the LSEC-KC crosstalk during KC development, (III) generate LSEC-specific knock-in mice to study LSECs in vivo, (IV) demonstrate which LSEC factors influence KC development and function. Importantly, understanding how the KC-TxFs and the LSEC-KC crosstalk control KC development and function will be essential for the development of novel therapeutic interventions for hepatic disorders in which KCs play a central role.

Keywords: kupffer cell,transcription factors,cellular identity,niche imprinting,tissue resident macrophages,liver sinusoidal endothelial cells