Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The GRASSHOPPER network: Jumping forward from preclinical development of pediatric cancer drugs to clinical implementation (GRASSHOPPER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Germany,France,Spain,Greece,Slovakia,Romania,Latvia,Jordan,Switzerland,United States,United Kingdom,Ukraine,Australia,Denmark
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 1687542.86
EU funding (EUR): 1656000.0
Participants: 17
Project status: SIGNED

Every year 16.000 children in Europe are diagnosed with cancer, and 2000 children (approximately 70 school classes) die from this illness. New therapeutic solutions are advancing rapidly however the optimization and implementation into clinical trials accessible for these children is lacking behind. New therapeutic interventions often don’t make it through the valley of death between preclinical development and clinical implementation. In addition, the accessibility between countries of new treatments varies largely. Therefore, the GRASSHOPPER consortium aims to create a multidisciplinary network of stakeholders in pediatric cancer development to boost implementation of new therapeutic interventions for children with cancer across Europe and beyond. GRASSHOPPER consists of 10 beneficiaries and 7 associated partners located in 16 countries: 6 academic European Comprehensive Childhood Cancer Centers (CCCC’s) and 3 non-European CCCC’s, 5 non-academic national leading Childhood Cancer Centers, 2 leading pharmaceutical companies and 1 non-for-profit drug developer. The consortium has 4 objectives: identification and preclinical validation of new immune interventions (1) and new molecular interventions (2), stimulating repurposing of available therapeutic interventions (3) and improving clinical validation of high potential therapeutic interventions for pediatric cancer (4). These objectives will be achieved by intersectoral secondments between the various beneficiaries and partners. The consortium expects that these objectives will lead to a strong international and multidisciplinary network, exchange of knowledge and expertise between sectors and countries and lead to highly skilled researchers, trained in pediatric and transferable skills, and with a large network for future career perspectives, that will jump over the valley of death and accelerate new treatments.

Keywords: pediatric oncology,cancer,preclinical and clinical research,solid tumors,leukemia
Open Digital Environment for Hybrid-Electric Regional Architectures (ODE4HERA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Germany,Belgium,Italy,France,Spain
Call: Open Digital Platform for Hybrid-Electric Regional Aircraft Design (HORIZON-JU-Clean-Aviation-2023-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 8788686.25
EU funding (EUR): 6902528.88
Participants: 15
Project status: SIGNED

The objective of the Open Digital Environment for Hybrid-Electric Regional Architectures (ODE4HERA) project is to enable and accelerate the development of Hybrid-Electric Regional (HER) aircraft thanks to improved tools and techniques implemented in a transferable and Open Digital Platform (ODP). HER configurations imply far higher complexity than conventional configurations while involving new aircraft technologies and broader collaboration across the value/supply chain. State-of-the-art digitalization techniques limitations put at risk the achievement of the 2035 HER Entry-Into-Service (EIS) target. To address these challenges, the ODP developed in ODE4HERA will combine MBSE, MDO, SDM and PLM technologies and extend them with novel open interfaces, formats, smart model and data transformation technologies efficiently handling and processing HER configurations complexity, including frontload verification at design stage and virtualize validation for improved virtual certification.

Keywords: hybrid electric regional,mbse,mdo,ivandv,plm,sdm,open platform
Defining the rhoptry kinome in Plasmodium falciparum and its importance for invasion of red blood cells (RhoptryPhos)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 191343.12
EU funding (EUR): 191343.12
Participants: 1
Project status: SIGNED

Malaria remains a major global health issue, caused by the apicomplexan parasites of the genus Plasmodium, with Plasmodium falciparum being the most virulent and lethal species. Malaria symptoms primarily result from repetitive cycles of parasite invasion, replication and egress within human red blood cells (RBCs). Invasion by the infective merozoite forms is facilitated by the secretion of factors from apically localized secretory organelles. Among these, the largest, known as rhoptries, contain proteins essential during invasion and subsequent intracellular development. Despite their critical role, the regulatory mechanisms governing their functions remain poorly understood. For instance, phosphorylation has been observed in several of these essential rhoptry proteins. However, the implications of these modifications are unclear, as no kinase has yet been identified within the rhoptries. Therefore, I hypothesize that kinases localize to rhoptry organelles and play important roles in merozoite invasion and intraerythrocytic development. Preliminary data supports this hypothesis, by showing that FIKK5, a non-essential kinase previously thought to be exported into RBCs, localizes to the rhoptry bulbs. Based on this, I propose to identify essential rhoptry kinases in P. falciparum and investigate their regulatory impact on other rhoptry proteins, as well as in invasion and intraerythrocytic development, using state-of-the-art proteomic, genetic and cell biological approaches. To achieve this, I will: 1) define the rhoptry kinome in P. falciparum; 2) characterize the functions of rhoptry kinases during parasite development; and 3) assess the impact rhoptry kinase disruption on the protein environment within rhoptries. Ultimately, through this proposal I will generate the first comprehensive proteome of the rhoptries in P. falciparum, while identifying the first kinases involved in regulating key rhoptry factors critical for maintaining infection of RBCs.

Keywords: plasmodium falciparum,rhoptries,kinases,phosphorylation,mass spectrometry,host pathogen interactions
Enhancing immunotherapies against solid tumors with TLR-switch receptor-armored T cells (TLR-T cells) (TLRT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Immunotherapy, particularly adoptive T cell therapies (ACT), has revolutionized cancer treatment, providing significant benefits to patients with haematological malignancies. Despite these successes, their effectiveness against solid tumors remains limited. A major unaddressed obstacle in treating solid malignancies with ACT is the suppression of T cells within the tumor microenvironment (TME), which hampers their sustained activity against tumor cells. Thus, there is a critical need to optimize these therapies to be effective against a wider range of cancer types. One promising approach involves engineering adoptive T cells with switch receptors (SRs) that convert the detection of extracellular suppressive signals into intracellular T cell activation. Damage-associated molecular patterns (DAMPs) are endogenous ‘danger’ ligands and powerful innate immune agonists that signal through Toll-like receptors (TLRs) to various cell types, playing an essential role in mounting protective immunity. However, the potential to utilize these innate immune signals to empower therapeutic T cells remains unexplored. This research proposal aims to enhance ACT against solid tumors by leveraging innate immune signals to improve T cell function within the suppressive TME. Specifically, the goals are (1) to design innovative SRs that amplify TLR costimulatory signalling upon detecting TME immunosuppressive factors, and (2) to incorporate these SRs into T cells, evaluating their therapeutic potential in both TCR-T and CAR-T therapies using complementary murine and human tumor models. By harnessing innate inflammatory signals, the proposed strategy seeks to boost fitness, cytotoxicity, and resilience of infused T cells, enabling them to navigate and function more effectively within the immunosuppressive TME of solid tumors. The advancements from this research could be transformative for cancer treatment paradigms, offering new hope for a broader spectrum of cancer patients.

Keywords: adoptive cell therapy act,tlr,switch receptor sr
Strengthening Democratic Resilience Through Digital Twins (TWIN4DEM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Netherlands,France,Germany,Italy,Sweden,Romania,Czechia,Spain,Greece,Hungary
Call: Computational Social Science approaches in research on democracy (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2999996.25
EU funding (EUR): 2999996.25
Participants: 12
Project status: SIGNED

TWIN4DEM brings together scholars of the social sciences and humanities, computational social sciences (CSS) and democracy stakeholders to jointly address one of the most pressing contemporary issues: what causes democracies to backslide? Combining various advanced CSS methods, TWIN4DEM prototypes the first ever digital twins of four European democratic systems (Czechia, France, Hungary and the Netherlands). In doing so, TWIN4DEM delivers four major breakthroughs. First TWIN4DEM develops a new agent-based conceptual model allowing to identify the causal pathways leading to executive aggrandisementn - the excessive concentration of powers into national executives - and threatening rule-of-law institutions. This will allow the systematic identification and testing of new hypotheses on the multidimensional causes of democratic backslide. Second, TWIN4DEM releases new cross-cutting tools to process and aggregate textual and non-textual data more efficiently and in real-time in an open, FAIR and GDPR-compliant manner. TWIN4DEM tools will not only allow democracy researchers to process more effectively the abundance of data on political life but also to enhance the transparency and legitimacy of democratic decision-making. Third, TWIN4DEM simulates, together with national policy makers and civil society organizations, policy scenarios to prevent and react against democratic backslide. This will enhance the effectiveness of interventions aiming at shielding rule-of-law institutions against external and internal threats. As a result, European democracies will be more resilient. Fourth, by formulating guidelines on scaling up the use of CSS in democracy research in a participatory, open and ethics-driven manner, TWIN4DEM paves the way for using such methods in a way that empowers citizens and reinvigorates the quality of democratic governance.

Keywords: democratic resilience,executive aggrandisement,digital twins,css,participatory research
Investigating the effect of composite microstructure on wave propagation characteristics and development of an ultrasonic-data-driven computational framework for composites damage mode identification (Microsonic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The EU is a world leader in the transport industry, especially aviation. It is predicted that the number of flights in Europe will increase to 13 million in 2028, 2.6 times more than those in 2020. This remarkable number of flights will place airworthiness at the heart of technology development which makes regular inspection, timely diagnosis of technical problems and optimising design and construction of aircraft components of paramount importance. Superior mechanical properties, especially a high strength-to-weight ratio make composites an ideal candidate for the construction of aircraft parts. However, detection and evaluation to maintain composite structural integrity are particularly challenging since they are inhomogeneous and anisotropic. Although Ultrasonic Guided Waves (UGWs) have exhibited strong potential for detecting damage signatures in composites, nucleation of defects and damage propagation occurring within numerous locations at several length scales make it difficult to track all the damage sites and mechanisms which is vital for improving composites design and production. Thus, understanding UGW interaction with complex anisotropic structures of composites that can be accessed considering composite microstructure is a fundamental issue that remains unresolved. Microsonic will bring a fellow with expertise in micromechanics and damage modelling together with the host institution carrying leading know-how in UGW interaction modelling to investigate the effect of composite microstructure, i.e. fiber size, volume fraction and distribution and micro-damage on wave propagation and establish the next generation of Ultrasonic (US)-data-driven computational frameworks developed based on the micromechanics outputs for composites damage mode identification. Microsonic will provide safer flights by establishing a robust tool for online monitoring of aircraft's structural health state and boost Europe to the forefront of the inspection and maintenance market.

Keywords: structural health monitoring,micromechanical simulations,damage diagnosis,ultrasound guided waves,complex composite structures,ultrasonic data driven algorithm
Preventing non-communicable diseases caused by the post-acute phase of cOvid-19 INfecTion (POINT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Denmark,Estonia,Belgium,Germany,Greece,Switzerland,Italy,Slovenia
Call: Relationship between infections and non-communicable diseases (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6676490.0
EU funding (EUR): 6676490.0
Participants: 10
Project status: SIGNED

The post-acute phase (PAP) of COVID-19, occurring ≥4 months after the acute phase, is associated with an increased risk for the development of non-communicable diseases (NCDs). The risk of complications in this phase does not depend on the severity of the acute phase. In the EU, more than 183 million cases of COVID-19 have been reported and up to 70% of patients suffer reduced organ function in the PAP. Our conservative estimate it that 5% of people who have suffered COVID-19 are at risk of developing NCDs of the pulmonary, cardiovascular and renal systems due to the PAP. To avoid the significant socioeconomic costs related to this burden, POINT will develop knowledge-based biomarkers for prevention and management of NCDs, a virtual twin model that offers clinical decision support, and clinical guidelines and recommendations for the entire health care value chain with special attention to vulnerable groups. We will fulfil an unmet need for knowledge and tools to minimize the risk factors of the PAP at the optimal point in time, when healthcare systems will have to redirect their focus from the acute phase of COVID-19 to the post-acute phase. The outcomes of POINT will aid the health care value chain already from an early phase of the project. Furthermore, POINT will correlate and promote knowledge on the development of NCDs in general and the risks of PAP from other infectious diseases. POINT will meet the challenges with a holistic approach from a truly interdisciplinary consortium consisting of clinical experts, molecular biologists, behavioural scientists, and computer scientists, who will take advantage of cohorts of more than 6 million Europeans, and cross-sectional biobanks from more than 6000 Europeans. Researchers will work together with standardisation experts, an end-user organization representing >120.000 physicians, as well as a dedicated partner for data management ensuring rapid absorption of the outcomes of the project by all stakeholders.

Keywords: post acute phase of covid 19 pulmonary,cardiovascular and renal diseases guidelines virtual twin
ToFUEL – AN INTEGRATED BIOREFINERY FOR SUSTAINABLE AVIATION FUEL PRODUCTION FROM TOMATO RESIDUES (ToFuel)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Austria,Portugal,Croatia,Finland,Germany,Belgium,Italy
Call: Development of smart concepts of integrated energy driven bio-refineries for co-production of advanced biofuels, bio-chemicals and biomaterials (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 3499997.5
EU funding (EUR): 3499997.5
Participants: 11
Project status: SIGNED

The production of Sustainable Aviation Fuels (SAF) from renewable feedstock, such as agricultural waste streams, is vital in reducing the carbon footprint of the aviation sector and achieving the European climate neutrality goals. The ToFuel project focuses on converting waste streams from tomato production and processing into SAF, animal feed, fertiliser and nutritional oil via an innovative, efficient biorefinery concept. The innovative biorefinery concept efficiently processes a variety of feedstock, including agricultural residues and organic waste. Addressing key challenges in biorefining- such as low product concentrations and complex, variable input streams, and water management, all of which contribute to high energy demand- the ToFuel project aims to develop advanced, integrated CO2-neutral SAF production technologies. The overall process includes biomass fractionation via extrusion and hydrothermal liquefaction, carbon capture using algae cultivation, microbial lipid fermentation on both liquid and solid media, the pre-concentration and purification of process streams by developing and adapting new technologies, and the upgrade to SAF via the HEFA route, to achieve cost parity with other biofuels. The project will provide open-access models for process simulation, (social) life-cycle assessments, and life-cycle cost calculations, along with strategies for scale up. By project completion, the core technologies will reach TRL 5, ensuring industrial readiness. A major outcome of the project is expanded knowledge of biorefinery, water management strategies, and carbon capture and utilization via algae, thereby reducing fossil resource dependency, strengthen Europe’s leadership in sustainable fuel technologies and contributing to new green job creation. The ToFuel project will maximize impact through a clear communication and dissemination strategy, including stakeholder workshops at European and local levels, along with accompanying exploitation measures.

Keywords: smart concepts for energy driven biorefineries waste utilization carbon capture biomass fractionation innovative water management denitrogenation hefa saf tomato residues
Deciphering female’s SEx hormones - MIcrobiota interactions during a menstrual CYCLE for an efficient personalized medicine in cardiometabolic disorders (SEMICYCLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1499286.0
EU funding (EUR): 1499286.0
Participants: 1
Project status: SIGNED

Cardiometabolic disorders (CMD), a group of conditions that include cardiovascular diseases, type 2 diabetes and metabolic syndrome, are characterised by dysfunction of glycaemic and/or lipid metabolism. Clinical manifestations, severity and progression are different between sexes, the underlying mechanisms of which are largely unknown. The poorer prognosis in women globally calls for an urgent need for better women’s tailored prevention and treatment strategies. Still, for an efficient personalised strategy, female-specific mechanisms have to be identified. The SEMICYCLE project will systematically investigate female’s sex hormones-microbiota interactions to unravel female-specific microbiota features regulating glycaemic and lipid metabolism in women during homeostasis and diseases. Findings of this research project will pinpoint key mechanisms useful to improve current prevention and diagnostic tools as well as therapeutic options of CMD. SEMICYCLE will follow up 300 healthy women during one menstrual cycle and longitudinal cross-omics data (five layers of information from host genome, gut microbiome, gut metabolome, vaginal microbiome, plasma proteome) will be generated, analysed and integrated with female sex hormones variations, lifestyle and diet, glycaemic and lipid phenotypes using state-of-the-art methodologies and computational approaches. Subsequently, mechanisms identified during homeostasis will be investigated for association with CMD onset and progression, using already existing cohorts totalling more than 10,000 samples. This research is based on my expertise and that of my research group in generating and analysing omics data in large data sets. Findings will reveal previously unknown microbiota regulators of CMD in women thus offering alternative routes for prevention, diagnosis and treatments in women, a necessary step for an efficient personalised medicine.

Keywords: sex specific mechanisms sex hormones gender medicine