Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Study of molecular events triggering the cytosolic enrichment of SUMO activating enzyme and its implications in seed quality. (SUMOCell)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2026-04-30
Duration (months): 42.0
Total project cost (EUR): 330428.88
EU funding (EUR): 330428.88
Participants: 3
Project status: SIGNED

Post-translational modifications by SUMO (Small Ubiquitin-like MOdifier) modulate protein activity through regulation of subcellular localization, protein activity and stability, and protein-protein interactions. In plants, SUMO is essential during seed development, modulates hormone signaling, and biotic/abiotic stress responses. Several studies point to a nuclear enrichment of SUMO conjugation machinery, which is consistent with a preferential nuclear localization of the SUMO targets. Nonetheless, non–nuclear targets exist and the molecular mechanisms that mediate their modification remain elusive. Dr Lois’s group has uncovered a novel regulatory mechanism consisting of the processing of the C-terminus of the SUMO E1-activating enzyme large subunit, SAE2. Processed SAE2 partially localize to the cytosol and the processing activity is prominent at the transition between embryo growth and seed maturation. Accumulation of SAE2 in the cytosol promotes cytosolic SUMOylation and behave as a signal for growth arrest, suggesting that SAE2 processing could contribute to finalising embryogenesis. SUMOCell aims to uncover the signals that trigger SAE2 cytosolic localization and the cellular responses activated by cytosolic SUMOylation. First, with Duke University partner, we will study SAE2 subcellular dynamics using super-resolution microscopy, under hormone treatments and stress challenges. Second, we will study the physiological processes regulated by SAE2 localization to the cytosol. For that, we will perform single-cell RNAseq studies from cells enriched in cytosolic SAE2. Bioinformatics analysis will be carried out by a placement at Sequentia SL. Finally, we will analyse physiological parameters related to seed quality. Data obtained from cell studies, transcriptomics and seed performance will be integrated in a signalling model to understand the role of cytosolic SUMO conjugation in seed development, providing a multidisciplinar training program.

Keywords: sumo,arabidopsis,nucleocytosolic partitioning,super resolution imaging
Gnss-r sateLlITe earTh obsERvation (GLITTER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Netherlands,Luxembourg,United Kingdom,France,Spain
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2788603.2
EU funding (EUR): 2667448.8
Participants: 10
Project status: SIGNED

GNSS-R is a technique to carry out Earth observation based on reflections on the ground (or sea, or ice) of signals originating from GNSS (Global Navigation Satellite System) signals. The proposed project consists of educating a new generation of experts, at doctoral level, able to bring a qualitative leap to this technology. The scientific and technological goal consists of developing such systems based on a synchronized constellation of Cubesats. An important advantage of this arrangement is the very low cost of cubesats and the possibility to increase resolution based on beamforming from the satellites. Ground truth, as well as some of the methods, will originate from near-field radar technology. This will require further research on all segments of GNSS-R technology and beyond: launching and adjustment of cubesat formations, RF synchronization, interferometry between moving platforms, calibration of RF front-ends, ground testing making use of drones, cubesat systems, on-board processing, data transfer and analysis, translation into ground truth and into predictions important for climate change studies and for optimal territory management. The project may also benefit to other technologies making use of interferometry, such as radio-astronomy and phased array based communications. It is also expected to assist industry segments making use of GNSS signals, such as precision agriculture, forestry and sea and land management.

Keywords: microwave technology,signal processing and data analysis,antennas,gnss,satellites
Ultra-High Speed memories for unprecedented cloud-computing performance (HIGH-MEMO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-04-01
End date: 2024-11-30
Duration (months): 32.0
Total project cost (EUR): 5060416.66
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Static Random-Access Memories (SRAM) are bottlenecks. In IoT devices, they consume significant power when the device is idle. In high performance applications such as telecommunication infrastructure, data centres, and stationary devices they limit the processor performance. Xenergic’s mission is to design SRAM that revolutionise system-on-chip power efficiency. For IoT devices, we design SRAM that reduce energy consumption by 70-90% when the device is idle. For high performance applications our SRAM have the potential to reach 2-3x higher speed and to reduce energy consumption by 30% compared to competing SRAM. To capitalise on a >€280B annual market opportunity, we provide our customers with IP on SRAM design tailored to their requirements and profit from royalties on their sales. Our ultra-low energy memories are gaining strong traction from leading semiconductor companies. Now, we seek an investment from the EIC Accelerator to make our ultra-high-speed memories market-ready.

Keywords: energy efficiency,internet of things,embedded pervasive systems,lowe power design,high performance computing,artificial intelligence,cryptocurrency
Mitigating Antimalarial Resistance Consortium in South-East Africa (MARC SE-Africa)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: South Africa,Netherlands,Sweden,Norway,United Kingdom,Rwanda,Germany,Australia,Uganda
Call: Promoting implementation of research results into policy and practice (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-04-01
End date: 2027-03-31
Duration (months): 48.0
Total project cost (EUR): 4170631.25
EU funding (EUR): 4170631.25
Participants: 10
Project status: SIGNED

BACKGROUND: Gains achieved in reducing the burden of malaria and advancing its elimination are now threatened by the independent emergence and local spread of artemisinin-resistant parasites in East Africa. Protecting the efficacy of the current first-line malaria treatments, all of which are artemisinin-based, is now a top public health priority. OBJECTIVE: The Mitigating Antimalarial Resistance Consortium for South-East Africa (MARC SE-Africa) is designed to promote the translation of evidence of artemisinin and partner drug resistance of public health significance into policy and practice. METHODS: MARC SE-Africa brings together clinical researchers with experience in implementation research, experts in malaria chemotherapy and health policy, national malaria programmes and end users. Together we will improve estimates of antimalarial drug resistance and co-design a costed, Regional Detailed Action Plan to respond promptly to emerging antimalarial drug resistance. Dynamically-updated, evidence-based malaria treatment guidelines and graphic evidence summaries using MAGICapp will be developed, disseminated and evaluated. EXPECTED RESULTS: Predictive maps will better define antimalarial drug resistance for all eighteen South-East African malaria-endemic countries. We will expedite evidence sharing on antimalarial drug resistance with policy makers in at least eight countries. We will help at least four countries respond promptly and effectively to these results. We will facilitate the use of evidence on antimalarial resistance to inform better malaria treatment policies and will evaluate their uptake into clinical practice by primary healthcare workers in at least two countries. This will provide an evidence-based, reproducible model to mitigate the threat of antimalarial drug resistance and ensure sustained effective malaria treatment, including for the vulnerable communities that bear a disproportionately high burden of malaria and its sub-optimal treatment.

Keywords: malaria,artemisinin drug resistance,malaria treatment policy,south east africa
NETWORKING CENTER FOR EXCELLENCE IN NANOELECTRONIC DEVICES FOR AIR MONITORING (NET4Air)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Romania,Ireland,Italy
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2026-04-30
Duration (months): 40.0
Total project cost (EUR): 1423825.0
EU funding (EUR): 1423825.0
Participants: 3
Project status: SIGNED

The overarching goals of NET4Air are: (i) to significantly advance excellence capacity and resources in IMT with a view of addressing the research and innovation gap and imbalance within Europe; (ii) to broadly increase IMT expertise, know-how and attractiveness in innovative nanotechnologies, materials, devices, smart systems, data analytics and best-practices for environment monitoring, (iii) to bring the IMT research, education and technology capacity to the new stage of Open Science, by enlarging its European partnership and by establishing a collaborative program with state representatives, local agencies, research centres, universities, industry and citizen associations, (iv) to foster regional excellence in devices and practices for air quality monitoring (v) to engage Romanian citizens in a participatory approach to air quality science and (vi) to apply European Green Deal principles for saving our environment and contribute to citizens health, wellbeing and prosperity. These goals will be translated in concrete actions using the specific Twinning Coordination & Support activities articulated in seven Work Packages. A plethora of activities such as training, staff exchanges, events attendance and organisation, and a Networking Centre for Excellence in environmental monitoring and remediation will be implemented to support NET4Air activities and to foster regional excellence in the field of air monitoring. An exploratory research project aiming to develop a low cost wearable/portable nanoelectonic based platform for air monitoring, demonstrated in four use cases will significantly contribute to societal, economic and environmental impact of NET4Air. A new department for research management and administration at IMT will enhance its capacity to initiate and join EU project and initiatives. The gender equality, diversity and inclusion strategy will be carefully implemented including hiring people for new jobs created in the project and beyond.

Keywords: sensors,system integration,air monitoring and remediation,nanotechnology
Dissecting Dust in the Distant Universe: A Panchromatic Study with JWST and ALMA (DistantDust)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1499643.9
EU funding (EUR): 1499643.9
Participants: 1
Project status: SIGNED

At the core of galaxy evolution is the evolution of the baryonic components that modify the observable properties of galaxies. A crucial component of the baryonic matter is the interstellar medium (ISM) that consists of gas and solid-phase metals called dust. Interstellar dust determines how galaxies look like from UV to IR, how the ISM behaves, and the very process of star formation that creates the stellar component that defines a galaxy. Despite our wealth of knowledge about dust in local galaxies, very little is known about the properties of dust grains, where it resides inside galaxies, and how it is formed, beyond the nearby Universe (i.e., at high redshifts). The fundamental importance of advancing our knowledge about dust at high redshifts is further underlined by the vital need to correct for its attenuation effects in the observed rest-frame UV/optical emission of high-redshift galaxies. This situation will fundamentally change in the next few years owing to the unprecedented capabilities of the James Webb Space Telescope (JWST). This ERC program capitalizes on the massive technological advance of JWST to take a holistic approach, physically and observationally, and conduct a panchromatic study of dust emission and absorption properties at two key cosmic epochs:1) z~1-3, dubbed as Cosmic Noon, the peak epoch of cosmic star formation activity, and 2) z~5-10, the early Universe and the epoch of reionization. Owing to my leading role in multiple deep extragalactic JWST surveys, my ERC group will take full advantage of the very first data from this revolutionary observatory. This will be done in synergy with ALMA and other powerful ground-based observatories such as VLT and Keck to observe the attenuation and emission properties of dust from rest-frame UV to submm wavelengths at Cosmic Noon and beyond. This ambitious research program will bring novel key insight into the physical processes that enable star formation and galaxy evolution throughout cosmic time.
Quantum and Classical Ultrasoft Matter (QLUSTER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Germany,France,Austria,Slovenia,Italy,Greece
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2473286.4
EU funding (EUR): 2473286.4
Participants: 15
Project status: SIGNED

QLUSTER is constituted as a collaborative network for advancing research in fundamentals and applications, training ESRs with broad skillsets and high adaptability to the increasingly knowledge-based economy of the EU, and with a strong commitment to communicating science to society. Despite similarities in phenomena, language and methods employed to study clustering and mesophase organization across widely different length scales — from subatomic to macromolecular — a coherent effort to bring distinct communities in classical and quantum soft matter together has not been yet undertaken. Our objective is to advance the fundamentals in such fields far beyond the state of the art, cross-fertilizing and creating permanent ties between communities that have evolved separately so far, and fostering the transfer of knowledge essential for a broad range of applications. The ambitious research and training programme will address the properties of classical and quantum soft matter systems under a common framework based on the underlying ultrasoft interactions of the constituents. Ultrasoftness is the key factor leading to the observed complexity in the dynamics, structure, and response to external drives of these different entities (complex polymers, soft colloids, Rydberg atoms in optical lattices, vortex matter in superconductors, etc). QLUSTER comprises a unique theory/experiment balanced team of specialists in quantum optics, polymer physics and macromolecular chemistry among others, providing a valuable platform for communication between the different communities of research in ultrasoft matter. The impact in the academic and private sector of the EU will be broad. There are no previous examples of similar initiatives in the world and QLUSTER will put the EU in a privileged position, through fostering transfer of fundamentals and methods, to innovate in large-scale sectors as e.g., tyre manufacturing, and to find innovative applications of quantum science.

Keywords: colloidal interactions,macromolecular solutions,complex fluids,polymer physics,self assembly,rydberg atoms,optical lattices,quantum matter
Predictive tool of seagrass health to optimize the design of low crested structures in the Mediterranean Sea (SEGRALCS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-10-31
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 3
Project status: CLOSED

Coastal erosion is one of the major global threats to people, the economy, cultural assets and ecosystems in many regions of the world and also in Europe. Valuable coastal ecosystems, such as seagrass meadows, are particularly threatened by these erosion problems and effective protection measures for their conservation are urgently needed. Low-crested structures (LCS) are the typical coastal defence in Europe, with a design mainly based on their hydrodynamic and morphodynamic behaviour and little attention is usually paid to the ecological consequences of their construction. The construction of breakwaters can affect seagrasses by altering the circulation and sediment transport to the adjacent habitat, but fragmented and scientific-based criteria are difficult to manage in present engineering design and therefore ecological impacts are often not taken into account. Within this research project, the creation of a new quantitative prediction tool will be investigated to allow civil engineers and decision-makers to optimize the design of breakwaters and reduce the uncertainty related to their environmental performance, contributing to the preservation and conservation of seagrasses during the lifetime of breakwaters. In particular, the project will focus on the Mediterranean Sea to ensure the persistence of two characteristics seagrass species, Cymodocea nodosa and the most important endemic and slow-recovery Posidonia oceanica. The fellowship will be carried out at the Universitat Politécnica de Valencia (UPV), in Spain, under the supervision of Professor Josep R. Medina, international expert in maritime and coastal engineering, in collaboration with Dr. Nuria Marbà, internationally renowned researcher on marine and seagrass ecology at the Instituto Mediterráneo de Estudios Avanzados (IMEDEA). A placement is planned at the engineering consultancy INGEOMAR to put into practice and refine the predictive model, boosting its integration in coastal protection proyects.

Keywords: coastal erosion,seagrass meadows conservation,low crested structures,nature based coastal defences,hydro morphodynamics,mediterranean sea,quantitative predictive tool,breakwater design,
Changing Childhoods in the Early Era of the WWW (WEB CHILD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1999419.0
EU funding (EUR): 1999419.0
Participants: 1
Project status: SIGNED

Online connectivity permeates the lives of contemporary children. Nonetheless, the history of childhood and the World Wide Web (the Web) has not been studied—a lacuna which mirrors the wider absence of the Web in contemporary history despite its invention more than 30 years ago. WEB CHILD combines the history of childhood and the Web to investigate how the emergence of the Web as a new interactive and connected medium with little adult oversight impacted childhood at the turn of the millennium (c. 1995-2005). To study the Web’s wide-ranging influence, three countries have been selected for comparison: the United States, Denmark, and South Korea. These were all digital pioneers, but had very different cultures of childhood. WEB CHILD has four work packages (WPs). The first three cut across all three countries and investigate the Web’s relation to childhood on three analytical levels: conceptually, socially, and materially. WP1 asks how the Web’s relationship to childhood was conceptualised in the public sphere. WP2 asks how children used the Web. WP3 asks what kinds of Web content were built for children. Using the findings from the first three work packages, WP4 explores similarities and differences in the influences of the Web on childhood across the three countries. The analysis uses sources ranging from the Internet Archive’s archived webpages to news items, interviews, surveys, contemporary research, and internet guidebooks. It combines computational analyses of archived webpages, e.g. text-mining, link analysis, and analysis of encoded interactive features, with methods and sources more traditionally used in history. Using archived web material, the project ventures into what has until now been uncharted territory in historical research, even if such sources and related digital methods are indispensable when historicising the recent past.

Keywords: childhood history web history media history new cultural history south korea the united states denmark web archives 1990s 2000s computational methods