Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIOCONNECT: Developing the Action Plan to Foster Baltic Region Innovation Ecosystem in Biotechnology and Synthetic Biology (BIOCONNECT)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Latvia,Lithuania,Estonia,Finland
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2023-CONNECT-01, 2023)
Start date: 2023-12-01
End date: 2025-01-31
Duration (months): 14.0
Total project cost (EUR): 533455.36
EU funding (EUR): 499625.0
Participants: 7
Project status: CLOSED

The BIOCONNECT project aims to help create a more robust, integrated, and inclusive Baltic ecosystem/cluster for biotechnology innovation as one of the key ingredients for the present and future economic competitiveness of the region. A strong and vibrant bioeconomy holds colossal potential to reinforce EU’s focus on sustainability and circularity, ensure a healthier, more active population - as well as pave the way for an exponential cascade of new applications so transformative as to be dubbed the Bio Revolution.
MYC suppression through innovative chemistry (MYSTIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

MYSTIC aims to revolutionize cancer treatment by advancing HeloMYC, a novel cell-penetrating protein therapeutic that targets the oncogenic transcription factor MYC. Developed using our innovative reCHEMbinant platform, HeloMYC represents a breakthrough in addressing an "undruggable" intracellular target, combining the specificity of protein therapeutics with enhanced cell penetration and stability. MYC, implicated in over 50% of human cancers, has long been considered an elusive target due to its complex protein-protein and protein-nucleic acid interactions and lack of druggable pockets. HeloMYC is a protein based MYC inhibitor that overcomes these challenges and through strategic chemical modifications achieves potent intracellular activity against MYC-driven transcription in cancer cells in preliminary studies. This 18 months project will focus on three key objectives: advancing HeloMYC's preclinical development; expanding and fortifying our IP portfolio to secure a strong market position; and developing a comprehensive commercialization strategy, evaluating spin-off and licensing pathways. The MYSTIC project has the potential to not only provide a powerful new tool against MYC-driven cancers but also to validate a novel approach to developing protein therapeutics against intracellular targets. Success could open new avenues for treating a wide range of diseases with previously undruggable targets, representing a paradigm shift in drug development. By bridging the gap between academic innovation and clinical application, MYSTIC aims to bring hope to millions of cancer patients worldwide and establish a new frontier in precision medicine.
Revolutionizing Indoor Energy: The Emergence of Low-Cost Eco-Friendly, High-Efficiency Kesterite Solar Cells (LEKPV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Indoor Indoor photovoltaic (IPV) cells have the potential to power distributed and remote sensors, actuators, and communication devices enabling the widespread implementation of Internet of Things. Commercial (CIGS, CdTe) and emerging (Perovskite, organic solar cells) photovoltaic technologies face several challenges for indoor applications including cost, toxicity, and stability. In contrast, kesterite materials are composed of earth-abundant, non-toxic elements and show excellent stability. This technology has recently achieved efficiencies of 14.9% under AM1.5G, demonstrating its high efficiency potential. However, its current deployment for IPV is limited by low efficiency due to the spectral mismatch with the indoor spectrum, consequence of its low bandgap (1.1 eV). This proposal aims to develop efficient kesterite solar cells with a higher bandgap tailored for IPV applications. This project will combine advanced numerical simulations with an eco-friendly DMSO process and innovative precursor ink design, novel thermal annealing, and tailored electron selective contacts which will lead to significant improvements in the device performance. The main objectives include: 1) To develop an advanced numerical model for kesterite solar cells, laying the theoretical foundation for device architecture design; 2) To design a compositionally flexible precursor ink that leads to sustainable and cost-efficient kesterite absorbers with flexible Eg (from 1.4 to 1.7 eV); 3) To synthesize high-quality kesterite films with using high-pressure thermal annealing; and 4) To deposit band-aligned electron selective contact materials for the various Eg kesterite. The project will lead to an impressive 25% efficiency for indoor kesterite solar cells and demonstrate efficient mini-modules. These original ideas will set the stage for affordable, bio-safe, and durable indoor solar cells. It also provides a technical approach for the comprehensive design of other emerging PV technologies.

Keywords: kesterite,indoor photovoltaics,thin film solar cells,critical raw materials free semiconductors
Atmospheric SPeciation of Iron : exploring the impact of wet and dry deposition to the SO marine productivity (ASPIRe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-03-31
Duration (months): 31.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

The ASPIRe project will provide the experienced fellow, Dr Morgane M.G. Perron, expert in biogeochemistry at the air-sea interface, unique competences in organic Fe speciation in rainwater and aerosols, which are currently missing to the research field of atmospheric biogeochemistry, at the University of Western Brittany (UBO). A secondment at the University of Liverpool (Uni. Liv.) will teach her new skills in voltammetry techniques. The project will consolidate her scientific expertise and maturity and strengthen her scientific network with the goal of holding a permanent academic position in France. ASPIRe proposes to develop a new analytical method to measure the organic speciation of Fe in dry atmospheric samples collected over the largely understudied regions of the Atlantic and Indian sectors of the Southern Ocean. Atmospheric Fe measurements produced during the ASPIRe project will enable a comprehensive characterisation of Fe speciation in the atmosphere over the Southern Ocean, especially the fraction of aerosol Fe which is effectively bioavailable to marine phytoplankton. This is of key interest as the lack of bioavailable Fe drastically limits marine productivity in this vast oceanic region, impacting the extent and magnitude of atmospheric CO2 drawdown by the Southern Ocean. A multi-disciplinary synthesis of new atmospheric Fe measurements produced by the ASPIRe project and new and existing oceanic Fe measurements from the GEOTRACES, SOLAS and SANAP research programmes in the same study region will refine the link between atmospheric Fe deposition and oceanic productivity in the Southern Ocean in the present time. This work will open perspective collaborations to model the impact of atmospheric Fe deposition under future climate conditions. The ASPIRe project contributes to the EU and United Nations Decade of Ocean (2021-2030) objectives to preserve our oceans, to increase scientific cooperation and to raise public awareness on climate change.

Keywords: iron binding ligands aerosol iron air sea interface southern ocean biological carbon pump
Perceptual Realities: Optimizing XR through Perceptually-Informed Experiences (PROXIE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1494667.5
EU funding (EUR): 1494667.0
Participants: 1
Project status: SIGNED

Extended Reality (XR) technologies—including Virtual Reality (VR), Mixed Reality (MR), and Augmented Reality (AR)—are rapidly evolving, offering immersive experiences that blend the physical and virtual worlds. While progress has been made in understanding basic perceptual and behavioral processes to create high-quality, engaging content, current perceptual models often oversimplify how users experience these environments. To create truly immersive and effective XR experiences, we need a deeper understanding of how users perceive complex, highly realistic immersive scenarios. Whether to optimize visual fidelity, manage attention, or improve system performance, human perception plays a central role in the XR experience. PROXIE aims to address this by studying perception in XR environments that mirror the complexity of real-world XR applications, pursuing ecological validity. Rather than focusing on simplified, constrained scenarios as in existing research, we will explore how perception is shaped by both the environment and the tasks users perform. By understanding how users process multisensory inputs while actively engaging in realistic, interactive tasks such as search or free exploration, we can inform content generation, visualization algorithms, and even hardware design to improve XR experiences. Our goal is to develop computational models of perception that predict how users perceive and respond to immersive environments—whether fully virtual or augmented—based on sensory inputs and tasks. These models will anticipate how users process their surroundings, allowing XR systems to adapt in real time. For example, the models may help optimize visual rendering, sensory feedback, and the overall user experience to match user needs. This will enhance applications such as telepresence, training, and simulations, ensuring XR experiences feel natural and responsive, bridging the gap between laboratory experiments and real-world use.

Keywords: extended reality,computational models of perception
Precision Lethality to overcome clonal heterogeneity in high-risk neuroblastoma (Precision Lethality)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1497981.25
EU funding (EUR): 1497981.0
Participants: 1
Project status: SIGNED

Tumors are heterogeneous in nature due to genetic instabilitTumors are heterogeneous in nature due to genetic instability, ongoing selection, and variable microenvironments with local adaptation. Many tumors thus necessitate combinatorial drug treatments to reach all cells. This is true also for neuroblastoma, the most common extracranial solid pediatric tumor. Despite the well-known importance of clonal heterogeneity, most in vitro drug combination strategies, including commonly used synergistic interaction, do not quantify subclonal drug response. Here recently developed cell barcoding strategies will be used to monitor survival of thousands of individual subclones in neuroblastoma organoids, under different drug perturbations. This lineage tracing strategy allows identification of cell populations that survive a specific drug, and to find other drugs that specifically target those cell populations. I call this strategy “Precision Lethality”. In this research program two different precision lethality methodologies will be developed, one where cell barcoding is used to identify drug combinations with low cross-resistance, and one that uses the possibility to express the barcode so it can be captured by single cell RNA sequencing. This allows assessing the transcriptional state before drug perturbation of cells that are known to be either drug resistant or drug sensitive. Combined with publicly available drug sensitivity data repositories, this will be used to construct a deep learning model to predict drug sensitivities of individual cells. Successful completion of this multi-disciplinary research program will identify and verify new drugs to complement standard of care consolidation therapy for neuroblastoma. I also envision that these studies will showcase to the broader cancer research community how cell barcoding can be used as a drug combination strategy to overcome clonal heterogeneity, which would increase the chances of finding curative cancer treatments.

Keywords: drug response,drug synergy,drug response prediction,deep learning,single cell sequencing,cell barcoding,expressed cellular barcodes,precision lethality,microwells,lineage tracing,rare cell survival
Unraveling the impact of polyfluoroalkyl substances on aquatic microbial communities to create biodegrading microbial consortia between mixotrophs and fungi (MIXFUN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Polyfluoroalkyl substances (PFAS) are compounds widely used in commercial and industrial applications. Due to their presence in many household products, they are often found in wastewater effluent and urban runoff, from where they reach other aquatic ecosystems. PFAS present several significant issues associated to their persistence, transport (they have been detected in more than 90% of European rivers); and health effects as endocrine disruptors. The main objective of the MIXFUN project is to understand how PFAS may impact the structure of aquatic microbial communities by favoring organisms capable of degrading them, and to use this information to develop biological systems (microbial consortia) based on organisms with high biodegradation potential in combination with physical conditions (ultraviolet radiation-UVR and temperature) that enhance their capacity. We know that the presence of organic carbon in PFAS molecules could be their Achilles' heel, and that those microbial organisms capable of using this carbon could biodegrade the compounds in a cheaper and more sustainable manner than physico-chemical treatments. Additionally, temperature can influence biodegradation metabolism, while UVR has shown a photodegradative effect on PFAS. Since microorganisms coexist in their natural environment with fluctuations in UVR and temperature, our proposal to create a hybrid system of microbial consortia under various UVR and temperature conditions could yield satisfactory results. To achieve this, we plan to identify mixotrophs and fungi that are favored through a gradient of PFAS-contaminated lakes and subsequently develop mixotroph-fungi consortia. By combining empirical data and predictive models, we will be able to determine the optimal growth and biodegradation conditions for these consortia. As a result, we expect to determine how the use of these consortia can take the degradation of PFAS to the next level, benefiting both human health and ecosystems.

Keywords: biodegradation,mixotrophs,fungi,polyfluoroalkyl substances,ultraviolet radiation,microbial consortia,environmental pollution
Novel effective solution to prevent & treat severe wounds (Murnia)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Türkiye
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Umayana, a pioneering biotechnology startup established in 2022, is dedicated to addressing severe wounds as a result of the toxic effects of chemotherapy and radiotherapy, such as oral mucositis and radiodermatitis. Founded by a team of women entrepreneurs and headquartered in Teknopark Istanbul, Umayana harnesses groundbreaking biotechnological research to develop non-toxic, safe, and effective preventative and curative formulations. Umayana's patented products are proven in clinical trials, supported by substantial financial backing from institutions like Halkbank and KOSGEB, and recognized through prestigious awards like the International Silver Patent Award. Murnia, Umayana’s flagship product, is an innovative gel formulation characterized by its unique anti-inflammatory, mucoadhesive, and analgesic properties, derived from the acidic extract of Commiphora molmol (Myrrh) resin. This compound shows promising results in healing and preventing the wounds caused by chemotherapy and radiation. The effectiveness of Murnia has been validated in various clinical settings, significantly reducing the incidence and severity of oral mucositis among cancer patients. With the support of the EIC Accelerator, Umayana aims to complete regulatory registrations, scale production, enhance its distribution networks, and launch globally. Umayana's focus on environmentally friendly solutions and its commitment to gender equality in its operations align with broader European health and sustainability goals. Umayana’s innovative approach aims to improve cancer care protocols, significantly reduce healthcare costs, and enhance the quality of life for cancer patients worldwide.

Keywords: prevention treatment severe wounds cancer non toxic curative solutions wound care formulations oral mucositis radiodermatitis deeptech biotech
The Making of Local Legal Cultures under Rome: A View from the Margins (Local Law under Rome)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1999019.0
EU funding (EUR): 1999019.0
Participants: 1
Project status: SIGNED

Law and order were Rome’s vehicles for displaying its imperial authority and supremacy over non-Roman subjects. However, Rome did not fill a legal vacuum; rather, it competed with established legal practices among communities in the Greek East. These communities took pride in their legal traditions, as they were being absorbed into the Roman legal order. Consequently, the sphere of law served provincials as a major arena for negotiating Roman power and demarcating their own local identities: what customs to maintain and what trends to resist? Despite scholarly interest in the plurality of laws under Rome, this project proposes an innovative cross-disciplinary study of these local legal cultures as an expression of provincial agency and self-determination. While previous studies were limited to the scattered remains of legal activities in the Greek East on papyri or on inscriptions, it is the premise of this project that only by integrating the hitherto neglected body of Jewish jurisprudence we may gain access into provincial perceptions of their legal cultures. Early rabbinic literature (1st-3rd centuries CE), which has been marginalized as an isolated phenomenon, is in fact the only comprehensive source of local law-making under Rome and is therefore the most appropriate framework for studying provincial legalisms in all of their forms. By applying a multi-dimensional comparative analysis of key legal fields, Local Law under Rome provides a structured method including the following stages for proceeding towards a new understanding of subordinate legal discourse: First, the project contextualizes each system of local law separately against the background of Roman legal administration and local traditions. Next, it discerns patterns of integration across different legal traditions, and finally it characterizes the distinct nature of provincial legalism, as means for cultural and political distinction in circumstances of law without power.

Keywords: ancient judaism,jewish law,roman law,indigenous law,roman imperialism,papyrology,anthropology of law