Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Processing and Characterisation of Micro and Nano Composites (NANOCOM-NETWORK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,Germany,Austria,France
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2010-06-01
End date: 2013-05-31
Duration (months): 36.0
Total project cost (EUR): 99000.0
EU funding (EUR): 99000.0
Participants: 4
Project status: CLOSED

“NanoCom-Network” is composed by 2 Universities in Europe (Universität des Saarlandes, Germany; and Technische Universität Wien, Austria), 1 Research Center (Helmholtz Zentrum Berlin, Germany) and 4 Institutions in Latinamerica (Centro Atómico Bariloche and Universidad Nacional de Río Cuarto, Argentina, Universidade de Sao Pualo, Universidad de Concepción, Chile) who will cooperate in the Advanced Processing and Characterisation of Micro and Nano Composites. The purpose of the network is to combine the different thematic specialties of different experts in the multidisciplinary field of materials science in order to design new composite materials with superior properties and performance. To achieve this goal it is necessary to develop in parallel new characterization techniques, especially for the 3D imaging and analysis of the material architecture. Techniques like Focused Ion Beam Tomography, x-Ray (including synchrotron) tomography and Atome Probe Tomography will be applied and further developed for the study of composite materials. In particular, Nickel reinforced with Carbon Nanotubes for electrical applications, Al-based Metal Matrix Composites for structural applications and Nanocomposites with nanostructured coatings for application in manufacturing technologies will be studied. 39 exchanges with the participation of 28 scientists with different level of experience (from PhD students till professors) will be carried out within the project. There is a particular good balance of experience levels among the participant universities as well as a balanced distribution of exchanges among the partners. The total amount of the project is 99.000 €. Two workshops will be organized in order to exchange experience among the partners, to enhance the transfer of knowledge as well as to discuss further common activities.

Keywords: materials engineering,materials technology,nanotechnology
Use of genomic and proteomic tools for the development of contaminant specific biomarkers for the environmental risk assessment of aquatic ecosystems. (GENERA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,France,Portugal,France,Spain
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2011-01-01
End date: 2013-12-31
Duration (months): 36.0
Total project cost (EUR): 282600.0
EU funding (EUR): 282600.0
Participants: 5
Project status: CLOSED

The use of genomic tools is rapidly increasing in ecotoxicology, and results from transcriptomic and proteomic studies of the effects of environmental pollutants are becoming more and more available. Apart from the knowledge of the mechanisms involved in toxic processes, the aim of conducting research on genomic and proteomic level is the development of contaminant specific biomarkers for the risk assessment of aquatic ecosystems able to respond at environmentally relevant low contaminant concentrations. However, even if important information is gathered on differential gene and proteome expression, the development of contaminant specific biomarkers in model organisms is still a task to be tackled. In this context, an attempt to joint efforts for the discovery and development of susceptible genes and proteins to be employed in routine environmental risk assessment is highly desirable. Several marine species from different organizational and trophic levels (the marine microalgae, Phaeodactylum tricornutum, and Cylindritheca closterium; the copepods Tisbe battagliai, Tigriopus japonicus, and Nitokra spinipes; the estuarine amphipod Melita plumulosa; the clam, Ruditapes decussates and the cockle Cerastoderma glaucum; the mussel Mytilus galloprovincialis; the oysters Crassostrea brasiliana, Crassostrea gigas and Crassostrea rhizophora; and the guppy, Poecilia vivipara) will be tested for the genomic and proteomic effects of the exposure to priority contaminants and the responses analyzed for similarities at different organizational levels with the aim to develop interspecies relevant biomarkers for environmental risk assessment of the most important contaminants, while at the same time transferring knowledge and experience by providing excellent training in cutting edge technologies between the participating institutes

Keywords: environmental genomics,genomics,proteomics,environmental risk assessment,ecotoxicology,pollution prevention,marine environment impact
European South American network on Combinatorial Optimization under Uncertainty (EUSACOU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands,Italy,Netherlands
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2010-08-01
End date: 2014-07-31
Duration (months): 48.0
Total project cost (EUR): 55800.0
EU funding (EUR): 55800.0
Participants: 4
Project status: CLOSED

The purpose of this program is to stimulate research cooperation between Europe and South America in the field of uncertainty in combinatorial optimization. Combinatorial optimization is a lively field in mathematics and computer science. It aims at finding a best solution among a finite or countably infinite number of solutions. In standard optimization techniques, we assume that all the relevant data to the problem are completely known. However, this assumption is not always realistic. In many scenarios, we need to optimize when the data is not fully available and decisions with wide-ranging implications have to be made in the face of incomplete data. In this project, we study methods for dealing with uncertainty in combinatorial optimization. We will study three different models for uncertainty. The first one is online optimization in which decisions have to be made without any knowledge of future information to be released. A second model is stochastic optimization in which the uncertainty is modeled by the assumption that part of the data is given only by probability distributions. The third model for uncertainty is by an algorithmic game theory approach. Here it is assume that the solution is obtained by the interaction of a multitude of autonomous agents, each of which is holding private information. Therefore, there is no centralized control that has access to all relevant input data and that is able to enforce the computed solution as the final outcome. The objectives of this international research staff exchange prgoram are: 1. Intensify th ejoint research in optimization under uncertainty among researchers in Europe and South America 2. Training of junior researchers 3. Disseminate and transfer knowledge obtained during the program among academics in South America and the European Research Area.

Keywords: combinatorial optimization,online optimization,stochastic optimization,algorithmic game theory
GRAIL-2: GNSS-based ATP System for Railway Low Density Lines (GRAIL-2)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Support to the European global satellite navigation system (Galileo) and EGNOS
Action type: Collaborative project
Countries involved: Spain,France,Italy,United Kingdom,Czechia,Germany,Portugal,Belgium
Call:  (FP7-GALILEO-2008-GSA-1, 2008)
Start date: 2010-09-01
End date: 2013-12-31
Duration (months): 30.0
Total project cost (EUR): 2066916.02
EU funding (EUR): 1279347.0
Participants: 12
Project status: CLOSED

The objective of GRAIL-2 is to develop and validate a GNSS based ETCS prototype/application in Rail Low Density Lines. Starting from the work of GRAIL, GRAIL-2 goes further in the implementation and testing of one of its applications so that a real validation of the application against user needs can be performed, thus achieving a system/application closer to a final product. The proposed application is Absolute Positioning, combined with Train Integrity, in a context of Low Density Lines. Absolute Positioning is considered to be a very promising application as it can achieve a full on-board localisation of the train, thus reducing or eliminating the trackside equipment for localisation (balises). Besides, combined with the Train Integrity application, we can achieve the “positive train detection” that allows a future implementation of “moving block” systems (future ETCS level 3). That is also compatible with other initiatives like Low Cost ETCS or Regional ETCS. Freight transport will also benefit by knowing the completeness of the train. The framework of low density lines is considered to be more adequate for a short-term implementation of the GNSS applications: - The operational requirements of the application are less demanding. - There is no need for interoperability in short term, therefore, we can propose an application without the need of a formal adoption of the changes needed in the ETCS specification, but allowing for a future interoperable implementation when the ETCS specifications will be upgraded. - Costs are kept low: The current ATP/ETCS means great investments in the LDL but this is not feasible because of the limited budget dedicated to the LDL in the railway community. The ETCS environment is also preferred because ETCS is a standard system whose features are well defined and already proven. Besides, it should be noted that ETCS is suitable for all kind of lines and it is flexible and easily adaptable as demonstrated in GRAIL.

Keywords: railway,safety of life,egnos,low density lines
Mediating and Moderating variable analysis in energy balance behaviours change interventions- an International collaboration (MEMO INTERNATIONAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands,Portugal,Belgium
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2010-05-01
End date: 2014-04-30
Duration (months): 48.0
Total project cost (EUR): 72000.0
EU funding (EUR): 57600.0
Participants: 4
Project status: CLOSED

The prevalence of obesity has increased steadily for the past several decades. The great public health burden of overweight and obesity requires effective intervention programs targeting energy balance behaviours (e.g. active transport, tv viewing, soft drink and snacking consumption). However, up to now the efforts to prevent overweight had disappointing effects. To better inform future systematic intervention development and to improve effectiveness of energy balance behaviour interventions, identification of how the interventions worked (analyses of mediators) and for whom the interventions worked (analyses of moderators) is needed. Identifying mediators of intervention effects can prompt future intervention developers to strengthen or add effective intervention components and to remove ineffective intervention components resulting in more cost efficacious interventions. In addition, indentifying moderations can stimulate intervention developers can seek for new intervention strategies for non-responders. The aim of the proposed exchange program proposal is to bring the field of mediation and moderation analyses applied in obesity prevention research to a higher level by strengthening and enriching the international cooperation in this research field. All partners in the proposed exchange programme are experts in the field of overweight prevention and studies related to the determinants of overweight and unhealthy energy balance. Although all three partners are experts in the field of overweight prevention, each partner has specific expertise, which brings us to the goals of the current exchange programme. There are specific approaches and techniques that we can learn from each other and which can be further developed through an exchange programme. Eventually, this will bring our research field to a higher scientific level, which will have a direct impact on the overweight prevention and development of effective intervention programmes in Europe and Australia.

Keywords: public health,social psychology,behavioural sciences,social sciences,epidemiology
Metacommunity dynamics of the fish surface mircobiome in health and disease: pathogens and probiotics (FISHPROBIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 248220.9
EU funding (EUR): 248220.9
Participants: 1
Project status: CLOSED

Wild fish stocks are coming under strain as the demand for cheap sources of protein increases. As a result, aquaculture has expanded to an industrial scale and now accounts for over a third of total fisheries production. The exceptional conditions farming imposes on commercial fish species is driving the emergence of new and more virulent bacterial pathogens, with huge associated economic losses to the sector. Correspondingly, antiobiotic use in aquaculture is widespread. Antibiotic resistance in fish pathogens is also now common. Indiscriminate antibiotic use contaminates the consumer food chain, threatens human populations via the lateral transfer of resistance genotypes to human pathogens, and ultimately reduces the effectiveness of these drugs in a clinical and veterinary context. Thus, there is an urgent need to limit the use of antibiotics in aquaculture and to find alternative strategies to treat outbreaks of bacterial disease. In this proposal the opportunistic bacterial pathogen F. columnaris is the target of study. This organism causes fatal skin disease in a range of freshwater fish species including catfish and salmonids. At Laval University, Quebec a unique in vivo model of this disease is in place - the Brook Charr. Furthermore, at Laval an effective in vivo probiotic comprised of four endogenous skin bacteria has just been developed. We propose to use next generation pyrosequencing to profile the surface microbiome of this fish in health and disease. Furthermore, we propose to use in vitro competition assays between probiotics and pathogen, in combination with Illimuna sequencing, to study the metatranscriptomics of a model antagonistic ecological interaction. Drawing on expertise at the Universite de Laval, as well as that at the world class Marine Ecology and Fisheries Genetic Laboratory, UK, this proposal will establish the molecular basis for this probiotic effect to inform the development of similar approaches in other diseases and fish species.

Keywords: aquatic biology,genomics,bacteriology,molecular evolution,population genetics,aquatic ecology,aquaculture,probiotiics,metatranscriptomics,metacommunity sequencing
Game-theoretic Resource Allocation for wireless Networks based on Distributed and Cooperative Relaying Units (GRAND-CRU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 178760.7
EU funding (EUR): 178760.7
Participants: 1
Project status: CLOSED

GRAND-CRU (Game-theoretic Resource Allocation for wireless Networks based on Distributed and Cooperative Relaying Units) is a two-year research project that involves two institutions, the Dipartimento di Ingegneria dell’Informazione of the University of Pisa, Italy (the return host), and the Department of Electrical Engineering of the Princeton University, USA (the outgoing host). The main goal of the GRAND-CRU project is to design innovative techniques to address the issue of resource allocation in the context of relay-assisted multicarrier wireless infrastructure networks, in which the mobile users are connected to the base stations through multiple relays. The concept of cooperative relaying has attracted a large interest in the last few years due to its potential for improving coverage, throughput, call blocking probability, power efficiency, and infrastructure costs. Among other optimization techniques, game theory has gained a prominent role, due to its inherent capability of deriving self-enforcing schemes using distributed algorithms. The innovative idea behind this project is to include important aspects into the formulation of the optimization problem: the concept of energy-efficiency, which, to the best of our knowledge, has not been considered in the literature in the context of resource allocation for multicarrier relay-based networks; the focus on decode-and-forward techniques, to exploit the benefits of digital processing and channel error correction; the emphasis on low-complexity distributed algorithms for multi-cell scenarios, so as to propose viable solutions for realistic environments, with possible application to 4G and beyond-4G cellular networks. The GRAND-CRU project also aims at creating a long-term collaboration between the two host institutions, through exchange of scientists and joint collaborations to be undertaken at the end of the IOF contract, and to increase the European competitiveness in an industrially-appealing field of research.

Keywords: technological sciences,wireless communications,infrastructure networks,4g and beyond-4g cellular networks,resource allocation,cooperative relaying,game theory,energy efficiency,cooperation
Ubiquitous mental health support systems for managing long-term mental health illness (UBICOM MENTAL HEALTH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-07-15
End date: 2015-07-14
Duration (months): 36.0
Total project cost (EUR): 279149.7
EU funding (EUR): 279149.7
Participants: 1
Project status: CLOSED

This fellowship is a significant step in Dr. Matthews’ career, bringing him back into full-time research leading an innovative project in e-mental health between Professor Gay’s lab in Cornell University and Dr. Doherty’s in Trinity College Dublin. The project will develop technologies to support individuals with bipolar disorder, an extremely challenging illness which has significant negative impacts on individuals, their families and societies. This project extends the EU’s E-Health initiative by applying ICT to the improvement of mental health.The candidate has an interdisciplinary background and his work to date in ubiquitous support systems provides a strong foundation to carry out the proposal and push this research area forward. Throughout Dr. Matthews’ career he has sought to identify areas for further personal development. His training objectives include establishing a full- time academic career, further developing interdisciplinary competencies and gaining commercialisation expertise. These goals will be met through formal courses and applied research. This fellowship represents Dr. Matthews’ 1st post-doctoral research position. At Cornell University, he will be able to work with world-class researchers in healthcare, social networks and bipolar disorder. Cornell and Trinity are among the best universities in the world and will provide the necessary materials, expertise and excellent support services to carry out this project. As an interdisciplinary project in a highly sensitive area, it will need experts in each field, all of whom have committed to this project.This fellowship is a vital step in establishing Dr. Matthews as a leading researcher in an emerging and increasingly important field. His ambition is to establish an interdisciplinary research centre for ICT & mental health. There is an opportunity to establish Europe as a world leader in this emerging area.

Keywords: technological sciences,health sciences,menal health,social networks,human computer interaction
Characterization of a major family of cell wall proteins of Clostridium difficile – the sortase family. (DIFFISORT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-08-15
End date: 2014-08-14
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Clostridium difficile infection (CDI) represents the most problematic hospital acquired infection in Europe. It is also increasingly recognized as a community-associated disease. Current treatments for C. difficile disease are inadequate and other strategies must be found to treat or prevent disease. C. difficile is an anaerobic Gram-positive, spore-forming enteric pathogen. After disruption of the intestinal barrier by antibiotics, spores of C. difficile germinate and bacteria multiply in the intestine. Toxins are released and cause symptoms of disease which include diarrhea, or in the worst case, pseudomembranous colitis.The crucial early step of C. difficile infection is colonization of the intestine. C. difficile, like most bacterial pathogens, displays proteins on its surface that may act as adhesins and facilitate interaction with the host in order to allow colonization. Gram-positive bacteria predominantly use their thick cell wall as a platform for display of surface proteins. Cell wall surface proteins can be covalently linked to the peptidoglycan by a sortase enzyme, a membrane-associated transpeptidase. Sortase enzymes and their substrates are promising therapeutic targets for the development of novel antibiotics. To date no sortase enzyme or substrates have been described in C. difficile, although we have identified several sortase and sortase substrate genes within the genome. The project described here will investigate the role of the C. difficile sortase enzyme and sortase substrates. A variety of state-of-the art techniques will be used to explore these proteins, including advanced molecular genetics, in vivo animal models of infection and structural biology. The characterization of sortase enzymes and sortase substrates will allow firstly a better understanding of the colonization process of C. difficile and secondly will allow the identification of new virulence factors, which constitute potential vaccine components.

Keywords: infections,health sciences,clostridium difficile,sortase,cell wall proteins,physiology,virulence,colonization,mutagenesis,protein crystallization,vaccine