Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
GMES side event at the Bridging the Gap conference (GMESATBTG)

Framework: FP7 — Cooperation
Programme: Space
Destination: Space
Action type: Coordination and support actions
Countries involved: Slovenia
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2008-03-31
End date: 2008-06-29
Duration (months): 3.0
Total project cost (EUR): 56200.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A prominent side event on GMES is planned during the Bridging the Gap confernece to celebrate the 10 years of this initiative due to GMES’ relevance for providing the relevant information to enable a better evaluation of the state of the environment. The current proposal will focus on this GMES side event taking place at the conference. The Bridging the Gap conference is co-funded by a separate proposal.

Keywords: celebrating the 10 years of the gmes gmes side event
European Molecular Biology Laboratory Interdisciplinary Postdocs (EIPOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-2-3-COFUND, 2007)
Start date: 2009-12-01
End date: 2014-11-30
Duration (months): 60.0
Total project cost (EUR): 9155700.0
EU funding (EUR): 3662280.0
Participants: 1
Project status: CLOSED

The European Molecular Biology Laboratory (EMBL) has a strong tradition in promoting interdisciplinary basic research in molecular biology. With 93 laboratories in eight Research Units at five facilities in four European countries, working on topics ranging from structural to organismal biology and from computational and biophysics to chemical biology, the EMBL is one of the top research institutions in the world. The idea of the new EMBL Interdisciplinary POstDoc (EIPOD) initiative is to make use of this unique international, multidisciplinary research environment for setting up a postdoc fellowship programme devoted to broadening the interdisciplinary education and expertise of Experienced Researchers (ERs). Once a year, we invite young researchers to propose interdisciplinary projects of their choice to EMBL faculty of their preference. Candidates are asked to contact at least two group leaders, preferably of different Research Units, to discuss and shape projects that bring together separate scientific disciplines or transfer techniques to new usage. Scientific excellence of applicants and interdisciplinarity of the proposed work are evaluated by an independent selection committee composed of EMBL Heads of Units and other external internationally renowned scientists in a two-step procedure, involving a pre-selection followed by an interview meeting. Besides high-level interdisciplinary research training, EIPODs receive additional vocational training, special career development support and can join our new double mentorship scheme. An active alumni network facilitates reintegration into national research environments. Fellowships last three years. The COFUND contribution will be used to increase the number of fellowships from 12 to 20 and to introduce additional social benefits for the EIPODs in accordance with the European Charter for Reseachers. We aim to maintain these improved standards beyond the COFUND period.

Keywords: natural sciences,molecular biology,interdisciplinary research,structural biology,cell biology,computational biology,biophysics,developmental biology,evolutionary biology
The control of protein synthesis in health and disease (PROTEIN SYNTHESIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-02-05
End date: 2013-02-04
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Protein synthesis is a key process in living cells, being required for cells to grow, divide, and respond to changing conditions, as well as being critical in gene expression. However, protein synthesis in an expensive process, using a great of energy and amino acids. It is therefore tightly controlled. This involves the regulation, by phosphorylation, of proteins involved in protein synthesis (‘translation factors’) and mRNA-binding proteins. My laboratory studies the roles of these proteins and the protein kinases that act upon them in regulating protein synthesis in mammalian cells. I am particularly interested in the mTOR (mammalian target of rapamycin) pathway, which is regulated by amino acids and hormones and controls several steps in protein synthesis. A major goal of this project is to achieve a more complete understanding of mTOR signalling and to establish how different signalling pathways and translation factors work together to control protein synthesis. This research will extend our knowledge of a key biological process also help optimize production of biological drugs’, a major interest in the pharmaceutical industry. My laboratory also has a strong interest in the mechanisms by which defects in the translational machinery or in its control lead to human diseases. For example, dysregulation of mTOR signalling leads to cancer and heart disease. We will explore the molecular mechanisms involved in this. Defects in a key translation factor (‘eIF2B’) cause a severe neurodegenerative disease (‘vanishing white matter’). We will employ multiple complementary approaches to understand how problems in protein synthesis lead to these diseases. This will provide valuable information for treating or managing them. Lastly, faulty control of the synthesis of proteins called cytokines leads to inflammatory disease. I will explore the mechanisms that normally control cytokine synthesis, which may lead to new opportunities for treating inflammatory diseases.

Keywords: protein synthesis,mrna translation,translation factor,protein kinase,signalling,protein phosphorylation,heart disease,cancer,neurodegeneration,mtor
Improving the Research Capacity of the Institute of Materials Research in Kosice (IMPROVING)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: International Co-operation
Action type: Coordination and support actions
Countries involved: Slovakia
Call:  (FP7-REGPOT-2008-2, 2008)
Start date: 2009-03-01
End date: 2010-02-28
Duration (months): 12.0
Total project cost (EUR): 97216.82
EU funding (EUR): 87855.0
Participants: 1
Project status: CLOSED

The objective of the present project aims to create the necessary tools for improvement the research capacity of the Institute of Materials Research of Slovak Academy of Sciences (IMR SAS) in Košice in the fields of nanomaterials and new technologies with the aim to increase it’s contribution to regional economic and social development and for better participation in FP7 and other international projects. This will be realized through; • an international independent expert evaluation of the level of the overall research quality and management & research capability of the IMR SAS and; • definition and preparation of an Action Plan for improving their research and development capacities, based on the results of the evaluation and on discussion with representatives of the Centres in Europe, regional research and development authorities and utilizing the possibilities of cohesion policy programmes of EU for 2007-2013.

Keywords: research potential,materials,technology,evaluation,action plan
VINNMER-PEOPLE (VINNMER-PEOPLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2007-2-3-COFUND, 2007)
Start date: 2009-04-01
End date: 2014-03-31
Duration (months): 60.0
Total project cost (EUR): 12460326.0
EU funding (EUR): 4984130.0
Participants: 1
Project status: CLOSED

The long-term objective of VINNMER-PEOPLE is to significantly contribute to the career development of more research-qualified future leaders. One systemic weakness which has been identified is that relatively few women are qualifying in comparison with men. VINNMER-PEOPLE is being implemented in order to promote women’s qualification routes. In accordance with the research bill, VINNOVA has allocated resources for the period 2007-2014 exceeding SEK € 55 million. VINNMER-PEOPLE will promote qualification and career development for people running needs-driven research within VINNOVA’s fields of activity in collaboration between academia, industry and/or the public sector. VINNMER-PEOPLE will add substantially to the international part and profile including its funding structure for trans-national mobility. VINNMER-PEOPLE has been tuned to mimic the individual fellowship schemes, mainly the IEF, IIF and OIF, under the People programme in FP7 in order to utilise the familiarity built up under the Marie Curie brand. VINNMER-PEOPLE will strongly emphasise the commitment of the host milieu to engage in the recruitment of the individual researcher. Therefore the host milieu has to commit them self financially to support part of the salary 33% or 50%, depending on action. All international actions are expected to run for three years. To summarize the some of the main features of the proposed programme: • VINNMER-PEOPLE has three different actions. 1. Incoming highly experienced international researcher (>10years). 2. Incoming international experienced researcher. 3. Outgoing international experienced researcher. • Pre-application grants. • Tutoring support for PhD’s at distance. • Follow-up of the career plan together with the applicant R&I milieu. • Networking activities for all participants under VINNMER-PEOPLE. • Interactive research is planned to be initiated during 2008 to develop VINNMER-PEOPLE.

Keywords: health sciences,natural sciences,physical sciences,technological sciences,communication sciences,information management
Social Impact Assessment Methods for research and funding instruments through the study of Productive Interactions between science and society (SIAMPI)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: Strategic Activities
Action type: Collaborative project
Countries involved: Netherlands,Spain,France,Netherlands,United Kingdom
Call:  (FP7-SCIENCE-IN-SOCIETY-2008-1, 2008)
Start date: 2009-03-01
End date: 2011-02-28
Duration (months): 24.0
Total project cost (EUR): 989744.17
EU funding (EUR): 793302.0
Participants: 5
Project status: CLOSED

Our project aims at developing a method for the assessment of the social impact of scientific research. We review current literature including experimental studies and conduct case studies in four different fields (nanotechnology, ICT, health, social sciences) with various grades of social impact, in both national and supranational settings. Our goal is both to enhance insight in social impact assessment and to develop assessment methods. We focus on social impact of research. However, since most studies of how research has an impact on society show the crucial role of productive interactions between science and society, our prime object of investigation is the identification of these interactions. Thus, social impact is not seen as the ‘logical’ consequence of a unilinear process, but as the outcome of an iterative practice in which researchers and stakeholders each play a role. By productive interactions we mean: Exchanges between researchers and societal actors in collaborative settings (networks) in which knowledge is produced and valued that is at the same time scientifically and socially robust and relevant. Therefore, we engage in our project not only researchers and policy makers, but also other relevant stakeholders in the various research areas. Analytically, we distinguish four main tracks through which such interactions may occur: (1) through direct personal contacts (ranging from mere meetings to complex arrangements for research collaboration), (2) mediated by specific outputs like expert reports, clinical guidelines, scientific advice, or through (3) the transfer of goods (products, social practices, therapies, policy tools), and (4) through funding or other support mechanisms, in short: people, texts, artefacts and support. Our objective is in the case studies to show how these interaction mechanisms form a necessary condition for research to have a social impact.

Keywords: social impact assessent of research productive interactions between science and society
Analysis of the roles of the TRPV2 calcium channel in inflammation (TRPV2PI3KMACROPHAGE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-03-02
End date: 2011-09-01
Duration (months): 30.0
Total project cost (EUR): 179649.73
EU funding (EUR): 179649.73
Participants: 1
Project status: CLOSED

Macrophages are key players in the front line of our immune system, responsible primarily for the recognition and destruction of bacterial and fungal pathogens. However, they are also involved in various inflammatory pathologies. Membrane receptors of chemokines control many aspects of macrophages functions by stimulating various 2nd messenger systems, important amongst these are PI3Ks and Ca2+. However the identity of the Ca2+ channels involved in Ca2+ influx and the cellular responses regulation by that Ca2+ are still poorly understood. The TRPV2 calcium channel is expressed in immune cells, up-regulated during their activation, interacts with some proteins involved in the regulation of the actin cytoskeleton and plays a role in chemotaxis. Moreover, PI3K can regulate TRPV2 activity. The complementary objectives of the project will be to i) define the PI3K-dependant signalling pathways leading to the translocation of TRPV2 to the plasma membrane and its activation, ii) determine the physiological roles of the channel in a native environment. Mouse primary macrophages expressing either i) a TRPV2-GFP construct containing an extracellular flag tag or ii) specific shRNA against TRPV2 will be obtained using the innovative technique of adoptive transfer of haematopoietic stem cells transduced with appropriate retrovirus. Thus we can analyse the subcellular localisation of the channel and its translocation under various conditions. The physiological functions of the channel in macrophages will be precisely analysed in TRPV2-suppressed macrophages using techniques routinely used in the host laboratory. This work will be the first analysis of the endogenous TRPV2 in primary immune cells and will determine if TRPV2 is an important component of the pro-inflammatory signalling networks of macrophages and hence may be a potential target for novel anti-inflammatories.

Keywords: inflammation,calcium signalling,trpv2,pi3k,primary macrophages,animal models
Deepening and Broadening of Astroparticle Physics European Coordination (ASPERA-2)

Framework: FP7 — Cooperation
Programme: General Activities
Destination: ERANET
Action type: Coordination and support actions
Partnership: ASPERA-2 (ERA-NET)
Countries involved: Germany,Germany,France,Switzerland,Greece,Portugal,Belgium,Netherlands,Czechia,Romania,Italy,Spain,Poland,Switzerland,United Kingdom,Sweden,Croatia,Hungary
Call:  (FP7-ERANET-2008-RTD, 2008)
Start date: 2009-07-01
End date: 2012-12-31
Duration (months): 42.0
Total project cost (EUR): 2680934.0
EU funding (EUR): 2382504.0
Participants: 22
Project status: CLOSED

Astroparticle Physics has become a mature and well accepted science discipline. Demonstrated by many world class projects currently developed and run by European Astroparticle physicists, Europe as a whole is the main promoter and leading the field. As a merit of ASPERA (AStroparticle Physics European Research Area network, http://www.aspera-eu.org ), the ERA-NET in Astroparticle Physics funded in the context of FP6 for 3 years starting in July 2006, the community as well as the supporting funding agencies are becoming more and more organised. In order to allow a deepening and broadening of the successful ERA-NET work started with ASPERA in FP6, the extended consortium here presents a work programme for a second ERA-NET phase (ASPERA-2). Directly linked to the common action plan developed in ASPERA-1, the goals of ASPERA-2 are: 1. establish joint activities as the preferred way of funding R&amp;amp;amp;amp;amp;D programmes and large projects, 2. establish sustainable procedures of mutual coordination and benchmarking, 3. create a sustainable structure for European Coordination in Astroparticle Physics, 4. extend the network to all European countries with interest in Astroparticle Physics, 5. increase the efforts towards global inter-regional coordination, 6. update the roadmap, 7. increase synergy with environmental sciences, 8. transfer knowledge and technology with SMEs, and 9. continue and extend outreach activities.

Keywords: strategic planning,coordination,regions,funding,knowledge transfer,technology transfer,sme,basic research,interdisciplinarity,astroparticle physics
Structural studies of P-type ATPases and their characterization in native membranes (P-TYPE ATPASES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-04-01
End date: 2009-12-31
Duration (months): 9.0
Total project cost (EUR): 203817.53
EU funding (EUR): 203817.53
Participants: 1
Project status: CLOSED

P-type ATPases are cell-membrane pumps that are of fundamental importance in eukaryotes. The ion gradients created by Ca2+-ATPases or Na+,K+-ATPases are involved in signalling, maintaining the membrane potential as well as secondary active transport. Despite the recent progress in membrane protein crystallography, the lack of detailed structural information currently prevents a better understanding of function and specificity of cation pumps. One specific aim of this proposed research is to determine the structure of the plasma-membrane Ca2+-ATPase (PMCA) and to understand its regulatory mechanism. The autoinhibited PMCA will be recombinantly expressed in yeast, purified and crystallized. In addition, it is also planned to determine the structure of the activated complex consisting of PMCA and calcium-bound calmodulin (Ca2+-CaM). In order to deepen our understanding of cation pumps in their native environment, I further propose to investigate Na+,K+-ATPases in native membranes using a multi-technique approach. First, I will analyze complexes of Na+,K+-ATPase isolated from native membranes by mass spectrometry to identify peripheral proteins. In the next step, I plan to assemble those identified multi-protein complexes in vitro and structurally characterize them by cryo-EM. Finally, I plan to use AFM to investigate the oligomeric arrangement of Na+,K+-ATPases in native membranes. This multi-disciplinary project will hopefully expand our knowledge of cation pumps by putting atomic details in the context of the native environment and will concurrently allow me to gain experience in membrane protein crystallography that will complement my expertise in biophysical methods.

Keywords: p-type atpase,membrane proteins,x-ray crystallography,multi-technique approach,cation pumps
Lead Market European research Area network (LEAD ERA)

Framework: FP7 — Cooperation
Programme: General Activities
Destination: ERANET
Action type: Coordination and support actions
Partnership: LEAD ERA (ERA-NET)
Countries involved: Belgium,Italy,France,France,Greece,Spain,Spain,Spain,Spain,France,Austria,Spain
Call:  (FP7-ERANET-2008-RTD, 2008)
Start date: 2009-03-01
End date: 2014-02-28
Duration (months): 60.0
Total project cost (EUR): 1222839.33
EU funding (EUR): 1094769.0
Participants: 13
Project status: CLOSED

The LEAD ERA project is aimed at fostering the coordination of a series of trans-regional programmes dedicated to research and innovation within the highly innovative and technology based themes of the EU Lead market initiative. Through a process of intensive knowledge sharing of the regional competences and programmes, LEAD ERA partners will develop a joint Scientific and Technological strategy and the mutual tools and methods to foster RTD cooperation amongst their regional RTD stakeholders. The project is under the coordination of the experienced Walloon region and brings together the following innovative and science based regions, Veneto, Galicia, Franche-Comte, Lower Austria, Alsace, Basque Country, Andalusia, Navarra and Region of Western Greece; two countries: Greece and France. During the 60 months of the project, the partners will focus on the topic of the 6 Lead Markets identified by the European Union. All of them are at the crossroad of a number of scientific and technological fields which are difficult for a single region to master. It is therefore economically and scientifically relevant to link the research competences from the various regions to achieve new technological and knowledge breakthroughs. The current proposal LEAD ERA seeks to link the two initiatives (lead markets and ERANET) by adding the research dimension to the support provided to the lead markets. The regions will bring together a joint fund dedicated to the launch of ambitious RTD calls for proposals. These activities will provide new resources for their regional RTD actors to work at a European level and, trans-national projects involving RTD actors from the private or the public sector. A common strategy of communication and dissemination system will pave the way to create other joint collaborations between the various regional actors and even beyond the scope of the LEAD ERA consortium.

Keywords: lead market inititives,applied research,transnational collaboration,rtd calls