Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Electrochemically Switchable Fluorescent Probes for Biological Applications (ELSWIFLUOPRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

In current drug development, the visualization of therapeutic-agent translocation to the cell interior represents one of the essential problems. The transport across cellular membranes is frequently executed by cell-penetrating peptides (CPPs), and the process is routinely studied with fluorescence microscopy when the CPP is attached to a fluorescent marker. Nevertheless, the use of existing labelled CPPs is connected with several drawbacks. Especially, bonding of CPPs to the external face of the cell membrane make interpretation of the translocation difficult and can result in false positive results. Therefore, the development of novel electrochemically switchable fluorescent probe for the detection of CPP translocation is suggested. In this project, a fluorescent organic dye will be coupled with an electro-controlled fluorescent quencher, which could be activated/deactivated in response to applied electric potential. As the electron transfer cannot occur through the cell membrane, labelled external CPPs would be switched off through photoinduced electron transfer, and fluorescence only of internalized CPPs could be studied. Reversibility of the system represents a remarkable advantage as it would allow repetitive on/off switching of the fluorescent probe.

Keywords: cellular uptake,cell penetrating peptides,fluorescent probes,electrochemistry,photoinduced electron transfer
Fluorescence-based photosynthesis estimates for vegetation productivity monitoring from space (SENTIFLEX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Spain
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1499587.0
EU funding (EUR): 1499587.0
Participants: 1
Project status: CLOSED

Global food security will remain a worldwide concern for the next 50 years and beyond. Agricultural production undergoes an increasing pressure by global anthropogenic changes, including rising population, increased protein demands and climatic extremes. Because of the immediate and dynamic nature of these changes, productivity monitoring measures are urgently needed to ensure both the stability and continued increase of the global food supply. Europe has expressed ambitions to keep its fingers on the pulse of its agricultural lands. In response to that, this proposal - named SENTIFLEX - is dedicated to developing a European vegetation productivity monitoring facility based on the synergy of Sentinel-3 (S3) with FLEX satellite fluorescence data. ESA's 8th Earth Explorer FLEX is the first mission specifically designed to globally measure Sun-Induced chlorophyll Fluorescence (SIF) emission from terrestrial vegetation. These two European Earth observation missions offer immense possibilities to increase our knowledge of the basic functioning of the Earth’s vegetation, i.e., the photosynthetic activity of plants resulting in carbon fixation. Two complementary approaches are envisioned to realize quantification of photosynthesis through satellite SIF and S3. First, the work seeks to advance the science in establishing and consolidating relationships between canopy-leaving SIF and unbiased estimates of photosynthesis of the plants, thereby disentangling the role of dynamic vegetative and atmospheric variables. Second, consolidated relationships between SIF and photosynthesis will be used to build a FLEX-S3 data processing assimilation scheme through process-based vegetation models that will deliver spatiotemporally highly resolved information on Europe’s vegetation productivity. To streamline all these datasets into a prototype vegetation productivity monitoring facility, new data processing concepts will be introduced such as the emulation of radiative transfer models.
SPD nanostructured magnets with tuneable properties (SpdTuM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Austria
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1499475.0
EU funding (EUR): 1499475.0
Participants: 1
Project status: SIGNED

The decrease of weight and the increase of efficiency of magnetic components are essential for the reduction of CO2-emission and an improvement of their performance. Nanostructuring can dramatically improve the magnetic properties of soft and hard magnetic materials, hence opening up entirely new possibilities for the development of novel magnets. Nanocomposite magnets, for example, have been the focus of research since two decades. One of the remaining key challenges is to synthesize bulk nanostructured magnets of a reasonable size. In this project, this challenge is explicitly addressed and the potential to fabricate bulk nanostructured magnets by severe plastic deformation (SPD) as an innovative processing route is evaluated. The aim of the project is not only to synthesize different nanostructured magnets by SPD, but also to tailor their microstructure to attain the desired magnetic properties. It has been shown by the applicant that the magnetic properties of SPD processed nanocrystalline materials can be modified in wide range by decomposition of metastable solid solutions. By using different immiscible systems, decomposition mechanisms and annealing treatments, unique nanostructures can be obtained and the magnetic properties can be optimized. Through the choice of different magnetic starting materials, such as soft, hard and antiferromagnetic-ferromagnetic powders, different types of hard magnetic nanocomposites will also be obtained. Fine tuning of the microstructure and resulting magnetic properties through adjustments in the composition, SPD processing parameters and annealing treatments is planned. The project systematically addresses the entire process from the synthesis to the in-depth microstructural characterization by electron microscopy and atom probe tomography. In combination with simultaneous measurements of magnetic properties, the newly developed knowledge will be used to improve the performance of SPD processed nanostructured magnets.

Keywords: severe plastic deformation,nanocrystalline materials,magnetic properties,nanocomposites,mechanical properties,microstructure
Promoting Osteogenesis through Vascular Endothelial Cells (PROVEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 2205875.0
EU funding (EUR): 2205875.0
Participants: 1
Project status: SIGNED

The skeletal system and its vasculature form a functional unit with great relevance in health, regeneration, and disease. Our recent work has provided fundamental insights into the organization of the bone vasculature in mouse, its changes during aging, the heterogeneity and functional specialization of bone capillaries and endothelial cells, the regulation of these properties by Notch and hypoxia-inducible factor signaling, and the crosstalk with osteoblast lineage cells. Most importantly, we found that the manipulation of ECs in the aging animal can trigger the expansion of osteoprogenitors and thereby induce bone formation. PROVEC will now systemically identify and characterize endothelial cell subpopulations, their gene expression and functional properties in the healthy, aging, diseased and regenerating skeletal system. Preclinical models will establish whether endothelial cells are involved in the response to therapeutic treatments aiming at osteoblasts or osteoclasts, or if the modulation of ECs alone is sufficient to generate beneficial effects. Finally, PROVEC will investigate whether cultured mouse and human ECs can be endowed with beneficial properties to enhance bone formation in 3D organoid cultures and after transplantation into mice, which will be monitored by imaging in living animals. To achieve its ambitions aims, PROVEC will use a powerful combination of mouse genetics, disease models, genetic fate mapping, RNA-seq and single cell sequencing, computational biology, confocal and 2-photon microscopy, micro-CT imaging, pharmacological treatments, and cell biology methods to establish if and how vascular endothelial cells can be used to increase bone mineral density in preclinical models. The successful completion of PROVEC would be highly relevant for diseases such as osteoporosis, which affects around 27.5 million patients in the EU, generates annual costs of about 37 billion Euros, and for which we currently lack appropriate treatments.
Novel System for surface inspection and quality control for steel industries. (EddyEyes)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

European and global steel industry are facing several challenges, including meeting the high international quality standards. ISEND is a SME founded in 2006 and a acknowledged worldwide expert in industrial Non Destructive Test (NDT) systems that is participated by the Venture Capital ”Sodical” to support its international growth. ISEND has identified a need from its customers (spread trough Europe, Asia, North&South America) in a specific niche market of the Hot rolling mill industries for metal wire rod to which the current commercial solution have strong weakness. In this market, the producers are required to fulfil quality standards for surface cracks lower than 1% of diameter. Claims from customers against the lack of these standards can reach 4% of total plant year production. Surface cracks inspection technologies, are difficult to implement due to plants harsh environment (1200 ºC and rolling speeds up to 120 m/s), massive production rates (>10 Mton/year). Those systems must also deal with different alloy grades, applications, and final product sizes (diameters covers from 5 to 90 mm, wire coil lengths range is from 14,000 m to 750 m). Our proposed system EddyEyes® is a surface quality control system for Non Destructive Testing of metal products in production plants and is able able to detect, locate, display and storage surface cracks as smaller as 50 µm deep at 120 m/s rolling speed and 1200 ºC temperature in continuous operation. EddyEyes® selling price would be 0,4M€ (50% lower than our main competitors) what will allow the enduser payback period be less than 1 year. We have estimated that the worldwide market size for this product will be of 2.000 industries, from which we forecast that at least 20% will be interested in an improved quality control system. We foresee to be able in 5 years to position ourselves as leader in this niche market, reaching around 20% of the worldwide market and a turnover of 24 Million euro and creating 80 employees

Keywords: surface quality inspection for metal and steel industry electromagnetic testing,image processing,quality control in hot rolling mills eddy current sensors hot wire steel rod
Blazing the Trail: Enabling Exoplanet Imaging in the Habitable Zone with the European Extremely Large Telescope (Exoplanet Finder)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The direct detection of young and warm extrasolar giant planets in the habitable zone of nearby cool stars is one of the major goals of future ground-based high-contrast imaging (HCI) instruments. The motive is to study the physical and chemical properties of exoplanetary atmospheres and search for evidences of biosignatures. Direct imaging is the required technique to characterize exoplanets with spectroscopy of their atmospheres. However, the ability to resolve planet signal above bright stellar halo is still a challenge. A coronagraph is an optic, which suppresses the diffraction effects of the telescope by blocking the starlight but wavefront errors arising due to Earth’s atmospheric turbulence scatter starlight over the science region of interest and bury faint planet photons in stellar/speckle noise. Most of these errors are mitigated by the dedicated Extreme Adaptive Optics instruments. However, under the AO/ExAO WF residuals, imaging and characterizing exoplanets at small angles require achieving detection limit 10 to 100 times better than the state of the art. No existing ground-based HCI instruments have successfully disentangled the planet signals from stellar residuals at small angles. The proposal seek to develop and demonstrate wavefront sensing and control techniques that will enhance the planet detection sensitivity at small angles and will aid the existing HCI instruments in directly imaging young Jovian-like exoplanets at small angles around nearby stars. This research proposal will also enable next generation of exoplanets characterization instruments with the European Extremely Large Telescope to perform low resolution spectroscopy of Neptune or Super-Earth exoplanets in the HZ of low mass stars (for example M-type).

Keywords: extreme adaptive optics instrumentation,wavefront sensing,ground based high contrast imaging of extrasolar planets,coronagraphy,speckle suppression techniques
PULsar Science Across The Electromagnetic Spectrum (PULSATES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: TERMINATED

Over the last 50 years the study of pulsars has advanced our scientific knowledge over an incredibly broad range of topics, from particle physics, where they provide the only means of experimentally testing theories that describe the behaviour of matter at densities greater than those in an atomic nucleus, to enabling exquisitely precise tests of gravity. Since their initial discovery, over 2000 pulsars have been found in surveys worldwide, and observed from 100 MHz up to TeV gamma-ray energies, however ten times more than this are expected to be observable in our Galaxy. Over the course of this fellowship I will develop, and implement, an advanced survey strategy that, for the first time, will incorporate simultaneous observations from across the electromagnetic spectrum to exploit the truly broadband nature of the pulsar emission mechanism. Additionally, I will design innovative analysis techniques to extract the maximum scientific information both from the survey data, and the subsequent long-term observations. This fellowship will extend my existing knowledge of pulsar timing, from which the precision science is extracted, to include the other core aspect of pulsar astronomy, that of pulsar searching, bringing me into close contact with observational astronomy using both the current, and next, generation of radio telescopes. I will transfer my unique expertise in statistical analysis and precision pulsar timing to the host, where it will be applied to a wide range of projects, including international efforts to detect gravitational waves, and the ERC Synergy Grant “BlackHoleCam”, which involves the discovery and analysis of a pulsar orbiting the central supermassive black hole in our Galaxy. Further, I will gain critical skills from the group, both within astrophysics, and beyond, in writing observing proposals, project management, and disseminating my research to the general public, all of which will be vital as I pursue a career in astrophysics in Europe.

Keywords: pulsars,surveys,analysis methods,pulsar timing
Roma, Gypsies and Travellers' social in/exclusion in European urban camps (CAMP-BIVALENCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2018-09-01
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The project aims to analyse the role of Civil Society Organisations (CSOs) in Roma, Gypsies and Travellers’ (RGTs) in/exclusion in European urban camps. Triangulating individual semi-structured interviews, oral histories, archival research, and interpretative policy analysis, the interdisciplinary project combines Sociological, Socio-Anthropological and Socio-Historical approaches, contemplating two UK and two Italian superdiverse urban contexts as case studies. It contributes to three research streams: housing exclusion; RGT policy, and camps as socio-spatial configurations, and inaugurates a new interdisciplinary research field on Urban Camps. Dr Sigona, who will act as the Supervisor, is a leading scholar in migration and Roma research in Europe; his expertise is particularly complementary with Dr Picker research skills and knowledge coming from ten years of Sociological field-based research on Roma spatial segregation in five European countries. Due to the excellent quality of infrastructure, scholarly research and staff, the School of Social Policy and the Institute for Research into Superdiversity at the University of Birmingham are the most appropriate academic environment for Dr Picker to become, after the Fellowship, a leading social science scholar in the European Research Area.

Keywords: roma,gypsies and travellers,social exclusion,cities,camps,social policy,superdiversity,oral history
The Just City: The Ciceronian Conception of Justice and Its Reception in the Western Tradition (JustCity)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1775000.0
EU funding (EUR): 1775000.0
Participants: 1
Project status: SIGNED

One of the most innovative, and historically most influential, notions in the Western debate about justice is the political theory of Cicero (106-43 BCE). This project examines the ways a Ciceronian conception of justice came to be used in political argument at specific inflection points in the history of political thought. Ciceronian justice, responding to the breakdown of order, marked a significant departure from earlier Greek theories of justice. Cicero’s law-centered views on justice, both within and between states, were conceived against moral skepticism and shaped the later history of Western political thought in crucial ways. Cicero’s contribution has been obscured by philological trends keen on crediting Cicero’s political and ethical thought to Greek predecessors, on the one hand, and by the recent historiography on republicanism on the other. Neither of these can answer satisfyingly why Cicero’s legalized conception of justice has impacted Western political theory so thoroughly. How and why did Cicero distinguish his notion of justice from his predecessors? How did his conception come to influence both theory and institutions of justice until the enlightenment and beyond? The project challenges conventional views by focusing on crucial crossroads Cicero’s conception of justice faced from its inception in the late Roman Republic to early modern Europe. Bringing an innovative focus on the longue durée to the topic and bringing together methodological tools from intellectual history, ancient history and philosophy, and legal history, the project provides a deep historical perspective of Cicero’s conception of justice and its later reception. This reinterpretation of the intellectual history of justice in the West reevaluates the historical logic of Ciceronian justice, showing how and why this theory of justice came to play a crucial role in the European heritage by harnessing the reception of classical antiquity to long-term intellectual history.

Keywords: cicero,carneades,augustine,lactantius,gentili,school of salamanca,theories of justice,private property,republicanism,roman political thought,roman law,legal history,intellectual history,classical reception,political theory