Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Activities for the High Energy Astrophysics Domain (AHEAD2020)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Spain,Estonia,Ireland,Italy,Italy,Italy,Italy,Italy,Germany,Germany,Spain,Italy,Switzerland,Belgium,Hungary,Greece,Poland,France,France,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,Portugal,Portugal
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2019-1, 2019)
Start date: 2020-03-02
End date: 2024-12-01
Duration (months): 57.0
Total project cost (EUR): 9977472.5
EU funding (EUR): 9977472.5
Participants: 41
Project status: SIGNED

AHEAD2020 builds on our previous program, funded in H2020 as starting community, that allowed us to qualify now as advanced community. Our overall objective remains to advance further the integration of national efforts in high-energy astrophysics keeping the community at the cutting edge of science and technology and ensuring that observatories are at the state of the art. At the same time, AHEAD2020 aims at widening its horizons to further integrate activities with the newly born multimessenger astronomy, boosted very recently by the discovery of gravitational waves and cosmic neutrinos and of their first high energy counterparts. This will be achieved by a new large community of high energy astronomers, gravitational wave and astroparticle scientists. Along the road paved until recently, we will keep strengthening the theorethical efforts, also building up on the results of the observations of multimessenger sources; and continue opening the best infrastructures for data analysis of high-energy space and ground observatories. Furthermore we will integrate key infrastructures for on-ground test and calibration of space-based instrumentation and promote their coordinated use. Technological developments will focus on the improvement of selected detector, optics devices and advanced analysis tools for the benefit of future space missions and ground-based multimessenger facilities, with more emphasis on the observation of the new transient Universe. AHEAD2020 will support the community via grants for collaborative studies, dissemination of results, and promotion of workshops and a strong public outreach package will ensure that the domain is well publicised at both national and international level. AHEAD will also contribute to the benefit of society and to the growth of the European technology market, with specific studies of devices for cultural heritage, material composition and environmental monitoring, as well as the creation of a new generation of researcher.

Keywords: high energy astrophysics,space,multimessenger astronomy,x rays,gamma rays,gravitational waves,detectors,optics,data analysis,ground test facilities
Active managed Buildings with Energy performaNce Contracting (AmBIENCe)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Italy,Belgium,Belgium,Belgium,Portugal,Portugal,Portugal
Call: Enabling next-generation of smart energy services valorising energy efficiency and flexibility at demand-side as energy resource (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-06-01
End date: 2022-05-31
Duration (months): 36.0
Total project cost (EUR): 1999875.0
EU funding (EUR): 1999875.0
Participants: 15
Project status: CLOSED

The AmBIENCe project aims at extending the concept of Energy Performance Contracting to Active Buildings and making it available and attractive to a wider range of buildings. AmBIENCe will provide new concepts and business models for performance guarantees of Active Buildings, combining savings from energy efficiency measures with additional savings and earnings resulting from the active control of assets leveraging for instance price based incentive contracts (Implicit Demand Response). The willingness to invest in additional sensorisation, ICT an IoT will be increased by offering adjacent other-than-energy services, e.g. related to comfort, security or maintenance. Within the course of AmBIENCe, we will leverage the experience of the project’s business and research partners, and extend this through regional workshops where we will bring together various stakeholders to make an assessment of best practices and learnings. Based on this, an integrated modular concept will be proposed, and a proof-of-concept platform will be developed, to support the creation of Active Building Performance Contracts.

Keywords: demand response,active control,flexibility,storage,energy performance contracts,multi benefit services,buildings,energy efficiency
Integrated analysis of regulatory networks modulating seed coat permeability in natural accessions (InScope)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2022-01-01
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The European seed market is in constant expansion and improving seed quality is a key factor towards meeting the increase in demand. The seed coat is constituted from multi-cell layers that surround the embryo that will become the future plant. Seed coat properties and composition have a significant impact on seed quality. Notably, mutant seeds with permeable seed coats have defects in germination phenotypes such as lower dormancy, shorter longevity and reduced stress tolerance. The regulatory mechanisms that modulate seed coat permeability are, however, not well understood. The candidate has performed a genome-wide association study in Arabidopsis thaliana and identified ARR16 as a novel regulatory gene affecting permeability, this Arabidopsis thaliana response regulator (ARR) is a signaling component for the plant hormone, cytokinins (CKs). The project objective is to determine the transcriptional network involving ARR16 that controls permeability in natural accessions. In work package 1 (WP1), the spatio-temporal expression of ARR16 will be examined in seed tissues of permeable and non-permeable accessions with GFP reporter lines. Also, we will generate mutants with CRISPR/Cas9 gene edited haplotype copies, aiming to precisely define the cis-elements in the ARR16 promoter that determine seed permeability. Next, cytological analyses will be carried out on seed coats of ARR16 mutants to ascertain the composition and structural basis of the modified permeability (WP2). Finally, transcriptomes of mutant and wild-type seed coat cells isolated by laser microdissection will be analyzed, aiming to reveal CKs signaling networks mediated by ARR16 in seeds (WP3). The proposed project is feasible and appropriate for a Marie Skłodowska-Curie Individual Fellowship since the expected outcomes are innovative and generate knowledge for both fundamental and industrial research, while the candidate will improve his skills and knowledge of a specialized research area.

Keywords: seed germination,seed longevity,seed development,agricultural science,plant hormones and signaling,cytokinins
A novel solution to eliminate long wires during Intraoperative Neurophysiological Monitoring [WIONM] - Phase 1 (WIONM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Proposal resubmission, scored 13.24 in latest cut-off. Intraoperative Neurophysiological Monitoring [IONM] is an innovative technology to monitor nerve function integrity in the surgeries of nerves, spinal cord and part of brains. IONM reduces the risk of nerve injury up to 50%. Unfortunately, IONM is not problem free. IONM uses recording electrodes connected to long wires distributed on the patient under general anaesthesia. These long wires translate into several drawbacks, one is that they limit the manoeuvrability of surgeons and staff during surgery. Also, space constraints require routing the wires, making them behave as antennae and causing Electromagnetic Interference, which distorts the waveforms of weak electrical potentials from the nervous system. Finally, wired IONM solutions force neurophysiologists to monitor only one surgery per time, limiting their availability. Therefore, there is a clear need for a wireless IONM data link that could solve these issues. As a IONM devices distributor, SOINDE noticed this problem and decided to bridge this gap. Since 2014, we have been developing a Wireless IONM communication device, WIONM. WIONM’s Unique selling points are: -It eliminates long wires within the operating room while ensuring data integrity. -Plug-and-play architecture & compatibility with any commercial IOMN device. -Remote monitoring of multiple surgeries, helping to relieve the shortage of neurophysiologists. -It is up to 86% more economical than other commercial competitors. Once tested in Phase 2, we will market WIONM through an elaborate commercial plan that takes advantage of our extensive client portfolio and our already established partnerships with other medical suppliers. The success of WIONM will allow us to seize part of the €1.87 billion (CAGR of 9.2%) global nerve monitoring market. This will create a measurable impact on SOINDE, estimated on accumulated revenues of €52M and the creation of at least 20 new position by 2024.

Keywords: wireless,ionm,intraoperative neuromonitoring,neurophysiology,radio,medtech,operating,room,ergonomics,nerve injury,electromagnetic interference
Holding hands: cell-cell junctions in breast cancer metastasis and resistance to therapy (HOLDING-HANDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-02-28
Duration (months): 60.0
Total project cost (EUR): 1744921.0
EU funding (EUR): 1744921.0
Participants: 1
Project status: CLOSED

Breast cancer is the most common cancer in women, resulting in as many as 500000 deaths per year worldwide. Patients with breast cancer die unequivocally because of the development of incurable distant metastases and not because of symptoms related to the primary site. Understanding the complex, yet fundamental mechanisms driving breast cancer metastasis is critical to develop therapies tailored to this disease. The current understanding of how metastasis occurs is derived primarily from mouse models and largely dominated by the notion that single migratory cancer cells within the primary tumor can actively disseminate to distant sites and develop as metastatic deposits. Unexpectedly, our very recent study on patient blood samples has shown that cancer cell groupings, held together through strong cell-cell junctions, can break off the primary tumor and form a metastatic lesion up to 50 times more efficiently than single migratory cancer cells (Aceto et al, Cell, 2014). These findings lead to new open questions, yet highlight a previously unappreciated and targetable mechanism of cancer dissemination. Our preliminary data suggest that, among all types of cell-cell junctions, desmosomes and tight junctions are involved in this process, and therefore represent unprecedented options for developing a metastasis-tailored therapy for breast cancer. The two predominant goals of this proposal are: first, to define the role of specific desmosome (DSG2) and tight junction (CLDN3 and TJP2) components in the development of metastasis. Second, to address their involvement in cellular signaling and response to therapy. These studies will not only use our first-of-a-kind in vivo models developed from patients with breast cancer metastases, but also cross the boundaries between basic science and clinical applications. Our research has the long-term ambition to lead to a novel class of therapeutic agents tailored to block cell-cell junctions and prevent metastatic spread of cancer.

Keywords: metastasis,breast cancer,mouse models
Effect of 4500bar injection pressure and super-critical phase change of surrogate and real-world fuels enriched with additives and powering Diesel engines on soot emissions reduction (IPPAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Austria,Austria,Sweden,Sweden,China,Korea, Republic of,France,France,United States,United Kingdom,United Kingdom,United Kingdom,Japan,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 3928243.32
EU funding (EUR): 3928243.32
Participants: 20
Project status: CLOSED

Reduction of soot emissions from Diesel engines will be explored by utilising simultaneously (a) injection pressure between 2000-4500bar, (b) engine operation at supercritical conditions relative to the injected fuel’s critical point and (c) additives that improve atomisation and reduce pollutant formation. The detailed processes of nozzle flow cavitation/boiling, atomisation, phase-change and mixing, combustion and soot emissions under such conditions will be explored both experimentally and computationally. Experimental techniques include fuel property measurements, optical/laser diagnostics, high speed imaging, micro CT and high energy X-rays. Tests will be performed in CVC, optical engines, single-cylinder and production engine test beds. Identification of nozzle’s internal geometry and testing of clean and aged injectors with internal deposits build-up is central to the programme. Simulation tools to be developed include molecular-structure-based equation of state for the properties of surrogate, ‘summer’ Diesel and low quality Diesel fuels enriched with additives at elevated pressures/temperatures, DNS for bubble dynamics, cavitation and fuel atomisation, and soot oxidation in LES/RANS models coupling the in-nozzle flow with the macroscopic fuel spray development, mixing and pollutant formation in engines. The validated simulation models will be used as design tools to industrial development of fuels, fuel injection systems and Diesel engines. The 15 EU-funded ESRs plus 1 ESR funded independently by industry, will be recruited/seconded by universities, research centres and multinational engine, fuel injection system, fuel and fuel additives manufacturers from the EU, US, China, Japan and S.Korea. The new tests and the developed simulation tools, currently missing from the literature, will allow for an environmental assessment of the tested technologies at ‘real-world’ operating conditions, underpinning the forthcoming 2020 EU emission reduction directives.

Keywords: diesel engines,fuel injection
Boosting the growth potential of CEE start-ups on a pan-Europen level by creating new opportunities, synergies and opening the GATE of Startup Europe to the Balkans (MY-GATEWAY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Israel,Spain,Belgium,Slovenia,Romania,Hungary,Czechia,United Kingdom,Portugal
Call: Startup Europe for Growth and Innovation Radar (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 1571550.0
EU funding (EUR): 1498771.25
Participants: 11
Project status: CLOSED

The overall concept of MY-GATEWAY builds around the growth potential boost of CEE start-ups on a pan-European level by exploiting the Consortium partners' Startup Europe experience (as former coordinators and partners of the ICT-13 projects) and by implementing actions aimed at creating new opportunities and synergies within and beyond the MY-GATEWAY’s ecosystem. As a result of the project the CEE start-ups and the startup support organizations representing them will have better access to networks, finance and talent and will acquire the necessary skills and knowledge to maximise their growth potential. Moreover, the project will actively contribute to the expansion of the Startup Europe Community by opening the GATE of the Startup Europe to the Balkans. MY-GATEWAY involved the leading startup support organizations from Serbia, Macedonia and Bosnia-Herzegovina (as members of its Balkan Committee) who will continuously follow up the project activities, facilitate the knowledge transfer - MY-GATEWAY KEY - to the Balkan region and mobilize the Balkan start-ups to set up the "Startup Europe comes to the Balkans" Network.

Keywords: innovation ecosystem,synergies,access to finance,access to talents,capacity building,access to networks,procurement,scaling up,knowledge transfer
Information Processing in Tax Compliance Decisions (TaxInfoProcessing)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Various economic and socio-psychological factors have been identified as determinants of tax compliance, such as audit probability, level of fine, social norms, and considerations of fairness. However, these factors have an observable influence in some situations but not in others. Empirical studies neither reveal consistent effects of purely economic factors (audits, fines) on tax payments, nor of socio-psychological factors (social norms, fairness considerations). To determine when these factors have more pronounced influence on tax compliance decisions and when their influence is suppressed, information processing must be considered in combination with actual decisions. So far, research in the field has neglected information processing and concentrated exclusively on decision outcomes. The present research project applies eye-tracking and MouselabWeb as tools to observe cognitive processes underlying tax compliance decisions. In line with the recently influential slippery slope framework of tax compliance (Kirchler, Hoelzl, & Wahl, 2008), the central premise of the current project is that socio-psychological factors, such as social norms and fairness perceptions, influence the extent to which evasion and compliance decisions are based on economic considerations. Special attention is paid to inter-individual differences in information processing and their relation to underlying motivational postures. This ambitious and novel research project applies the investigation of cognitive processes underlying decision making to the important field of tax research where this approach has been neglected so far. The proposed project will provide new insights into tax compliance decisions and have a remarkable influence on tax behaviour research as it has the potential to crucially inform policy allowing for tailoring psychological interventions to positively influence tax compliance.

Keywords: tax compliance,social norms,procedural fairness,cognitive process,process tracing methods
Testing the value of a novel strategic approach and its cost efficacy to improve the poor outcomes in Cardiogenic Shock (EURO SHOCK)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Norway,Belgium,Belgium,Switzerland,Latvia,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Comparing the effectiveness of existing healthcare interventions in the adult population (H2020-SC1-2017-Two-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 6499572.88
EU funding (EUR): 6499572.38
Participants: 21
Project status: SIGNED

Heart attacks are common and can leave survivors suffering cardiogenic shock (CGS), with its extremely high risk of early death (42% versus 4% for non-CGS) and high incidence of chronic heart failure, with its associated socio-economic disease burden (ill-health, recurrent heart failure admissions, no return to full time activities, need for expensive therapeutic devices and life-long drugs). Outcomes from CGS are even worse in, females, the elderly (mortality>70%) and high risk sub-groups. The incidence of CGS in Europe alone is >50 000 patients pa. This unacceptably high mortality/morbidity rate represents a true unmet clinical need. No clear strategy exists to improve outcomes, with ad hoc therapies given too late in a spiralling, irrecoverable process. EURO SHOCK aims to improve outcomes for CGS patients. At its core is a robust phase3 randomised trial comparing a novel strategy of very early use of ECMO (Extracorporeal Membrane Oxygenation) to current standard of care. Evidence suggests very early ECMO will halt the spiral of decline and so significantly reduce 12 month death rate and need for heart failure re-admissions. Since both costs of CGS, and ECMO are high a health-economic cost efficacy analysis will be core. A cardiac magnetic resonance imaging sub-study will test novel protocols in sick patients and provide mechanistic data. We will test transfer networks for CGS patients and analyse ECG data to determine which patients benefit most from early transfer. Our multidisciplinary consortium comprises renowned physician-scientists, statisticians, health economists and technology providers, including specialised ECMO SME. EURO SHOCK will impact on heart attack survivors, healthcare providers and Europe`s medical technology sector by 1) reducing healthcare costs associated with CGS 2) provide novel cost effective framework for cardiac interventions 3) delivering innovative healthcare technologies and 4) informing guidelines for effective CGS intervention.

Keywords: myocardial infarction,cardiogenic shock,extra corporeal membrane oxygenation,randomised trial