Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Shedding light on the dark supermassive black hole growth in the early Universe (darkBHgrowth)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Understanding what drives the interplay between active supermassive black holes (SMBHs) and galaxies is one of the most debated issues in modern Astrophysics. The feeding, feedback and cosmic growth of active galactic nuclei (AGN) must have been much more effective in the early Universe than today. Nevertheless, little is known on the high-redshift (z>3) SMBH growth, as this early epoch may coincide with intense star formation and obscured SMBH accretion, both unaccessible with current X-ray data. Moreover, no constraints on the role of mechanical AGN feedback in shaping galaxy growth exist at z>1. These issues point to a lack of understanding of the big picture of AGN-galaxy evolution. The proposed project hosted at CEA will clarify the link between SMBH growth, star formation, and AGN feedback since z~5. For this, I will exploit a stellar mass complete sample of 150,000 galaxies with exquisite multi-wavelength data obtained in the COSMOS field. The novel combination of the most sensitive IR-radio data, and state-of-the-art tools for spectral modeling, will allow me to derive dust-unbiased AGN and galaxy properties with unprecedented accuracy. I will push this analysis for the first time to z>3 galaxies and to highly obscured systems at any redshift. The main objectives of this comprehensive work are twofold: (1) to trace the hidden growth of SMBHs since z~5 in star-forming and quiescent galaxies; (2) to constrain the role of the host galaxy in triggering mechanical AGN feedback over cosmic time. These are crucial steps in determining how AGN feedback has shaped today's galaxies and SMBHs. One of the specific strengths of this proposal is that all the core data are already available, ensuring the achievement of the proposed goals. This innovative project will complement the existing expertise of CEA in physics of star formation, distant galaxies and numerical simulations, providing a unique opportunity for knowledge growth.

Keywords: black holes,galaxy growth,high redshift,infrared,radio
Genetically enhanced, optically superior tissues (GHOSTS) (GHOSTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-12-01
End date: 2025-05-31
Duration (months): 66.0
Total project cost (EUR): 1496994.0
EU funding (EUR): 973067.75
Participants: 2
Project status: SIGNED

Most biological tissues are optically opaque, largely precluding access by light microscopy. In stark contrast, some living tissues and organisms are highly transparent. Examples include many deep-sea fish, your retina, and cells that we exposed to directed evolution. Here we propose to uncover the genetic basis of tissue transparency, such that living cells and tissue cultures can be optically cleared by precision genetics. For this we will combine insights into origins of retina transparency, and a set of unique methods, to answer the question how genetically cells become more transparent during directed evolution. Specifically, we will use a three-fold approach to find transparency genes that do not compromise cellular integrity. For this we will use i) directed evolution towards transparency while co-selecting for cell fitness, ii) extensive phenotyping of transparent cells, both optically and functionally, and iii) use of transcriptomics to rule out stressed cells, and those that deviate too much from wildtype gene expression profiles. Knowing about physiological transparency genes will allow unprecedented insights into living tissues. If model tissues in the lab were just 1% as transparent as some glass-like fish found in the deep sea, optical microscopes could unleash their full potential, and enable high resolution views into developmental processes in their native environment. We see further transformative potential especially in the fields of organotypic tissue models, functional brain imaging, as well as pharmaceutical screens in 3D tissue cultures.
Hydrodynamical approach to light turbulence (HALT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Australia,Israel,China,New Zealand,Russian Federation,France,United States,Brazil,Japan,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-04-01
End date: 2024-09-30
Duration (months): 66.0
Total project cost (EUR): 243800.0
EU funding (EUR): 243800.0
Participants: 12
Project status: SIGNED

HALT (Hydrodynamic Approach to Light Turbulence) is a research focussed training initiative consisting of world-leading institutions in the multidisciplinary fields of nonlinear optics, classical hydrodynamics, and statistical physics. Through the proposed network, the overarching research objective is to develop new pathways in the understanding of one of the most important unsolved problems in physics: the structure of turbulence, while simultaneously training a new generation of early-stage researchers in scientific and non-scientific topics such as the media relations, scientific communication, modern open-science polices, website design, intellectual property rights, and various research knowledge and skills related to the HALT programme. Using nonlinear optics as a testbed, due to its inherent analogies to idealised compressible fluid flow, both theoreticians and experimentalists will, under close collaboration with each other, produce an array of novel optical and condensed matter experiments and systematically develop new revolutionary theoretical kinetic approaches to probe and understand the hydrodynamic nature of light. Through new advances in the understanding of optical turbulence, the ambition of the consortium, composed of European partners coupled with institutions from Brazil, Russia, China and Japan, is to make meaningful connections to classical hydrodynamic turbulence to push the frontiers of the global turbulence research community. The global HALT network will forge strong collaborative relationships between theoreticians and experimentalists and lead to a new sustainable era of collective research in the turbulence community.

Keywords: turbulence,nonlinear waves,coherent structures,vortices,solitons
Revealing the Synapse Architecture and Plasticity by Structural Interactomics (SynLink)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1499243.0
EU funding (EUR): 1499243.0
Participants: 1
Project status: SIGNED

Brain function crucially depends on chemical neurotransmission at synapses, while, conversely, synaptic dysfunction underlies neurological and psychiatric disorders. Synapses are composed of more than 2,000 distinct proteins, spatially organized into specialized molecular machineries. During decades of efforts, researchers have acquired a wealth of knowledge on individual key components of the synapse. However, the overall picture of the spatial arrangement, molecular architecture and interaction network of the synaptic proteome remains largely uncharted. Furthermore, innovative methods that allow system-wide profiling of these organizational aspects of synaptic proteins are in great demand. I propose to develop a highly sensitive cross-linking mass spectrometry (XL-MS) pipeline to analyze structural and organizational features of the synaptic proteome at an unprecedented depth and comprehensiveness. In parallel, I also plan to establish quantitative XL-MS strategies to reveal global network rearrangements and complex-specific alterations during long-term potentiation, which arguably is the most attractive cellular model for learning and memory. Importantly, it is foreseeable that numerous novel insights can be discovered, for which I will use complementary approaches and tools, such as biochemistry, super-resolution imaging, structural modelling and network analysis to validate and interrogate their molecular details and network principles. These studies will yield groundbreaking insights into the molecular architecture of the synapse and thereby fill a crucial knowledge gap in neuroscience. Furthermore, they will provide a framework to gain a deeper understanding of the dynamic regulation in synaptic plasticity and synaptic dysfunction in neurological disorders.

Keywords: cross linking mass spectrometry,synapse,protein structure,protein interaction
Structure-preserving discretization of hierarchically-structured rotating covariant shallow-water equations using finite element exterior calculus (FEEC discretizations)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Accurate and reliable simulations of weather, ocean and climate require computational models that result from structure-preserving – e.g. mass or energy conserving – discretizations of the equations of geophysical fluid dynamics (GFD). This research project aims to derive, implement and evaluate various structure-preserving discretizations (of different order of accuracy) of the nonlinear shallow-water equations, which are suitable for weather/ocean/climate applications. The derivations will rely on a novel form of covariant equations of GFD that I have formulated using Differential Geometry, in which the equations are split into metric-free (topological) and metric-dependent parts. Based on the systematic discretization I have introduced for the split linear shallow-water equations, this project intends to extend this approach also to the split nonlinear case and to derive structure-preserving discretizations that preserve in the discrete case, too, the splitting into topological and metric terms. As the topological terms require less mathematical structure, we expect an advantage in terms of easiness of discretization and efficiency of implementation. To derive corresponding discrete equations, we apply finite element exterior calculus (FEEC) as recently Cotter and Thuburn, whose resulting discretizations of conventional covariant nonlinear shallow-water equations fulfil many desirable properties for geophysical applications. Moreover, compared to the split form I proposed, their discrete equations show a similar, however not identical, structure. We study the differences and use their derivations as guideline for ours. To implement and test the various models, we use the software libraries Firedrake and FEniCS. Besides a general “discretization recipe” to derive structure-preserving models, this project will provide open-source software which will be of practical use for the geophysical model community.

Keywords: geophysical fluid dynamics,finite element exterior calculus,differential geometry,structure preserving discretization,rotating nonlinear shallow water equations
All Organic Redox Flow Batteries (GLOBE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

European Union (EU) intends to significantly reduce the CO2 emissions in the following decades. To do this, the use of fossil fuels in all sectors and particularly in power sector will be continuously reduced and replaced with renewable energy sources. Such transition depends on proper electrical energy storage (EES) technology for renewable energy management in order to handle the varying solar and wind generated electricity. So far only redox flow batteries (RFB) show potential for renewable energy management because of: i) scalability between storage capacity and power; ii) short response time; iii) good cycling capability, iv) long discharge time and v) low cost potential. The use of state-of-the-art metal based RFBs is limited by their relatively high costs that inherently are linked to the low current and energy density. Recently a breakthrough in RFB technology is reported, high current densities are achieved in a RFB based on organic-halide electrolytes. Organic-halide RFB can store electricity at almost ten times lower life cycle cost compared to metal based RFB, due to increased current density and lower electrolyte costs. One of the objectives of the current proposal is to investigate feasibility and stability of organic-halide RFB. The main goal of the fellowship is to build All Organic RFB by replacing the halide part (Br2) with less hazardous and cheap organic electrolytes which have extremely fast electrokinetics: (2,2,6,6-Tetramethylpiperidin-1-yl)oxy (TEMPO) and hydroxylated anthraquinone di-sulphonic acids. Since latter are not commercially available, a new chemical synthesis routes will be developed. Nanoporous films and anion exchange membranes will be considered as an alternative to expensive proton conductive membrane-Nafion. All Organic RFBs show great potential for low cost EES and could facilitate EU transition to low carbon emission/renewable energy based economy.
A hydrophilic polymer material (HydroPLAST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Danish SME Jonsman Innovation ApS will target a major market opportunity through the market introduction of a new thermoplastic polymer (Tensistat) that creates truly hydrophilic devices right after injection moulding or extrusion. Like other thermoplastic materials, Tensistat can be used for many applications, but our R&D focus was to develop the best polymer for applications where hydrophilicity is mandatory for performance and safety (e.g. single-use medical devices such as diagnostic consumables, tubing for injectors, catheters and microfluidic devices). As devices produced with Tensistat are hydrophilic directly from the moulding machine, no post-processing, e.g. hydrophilic coatings are needed, meaning cheaper, safer and more reliable devices. By ensuring and demonstrating a maximum level of effectiveness and complying with the regulatory requirements, we will attain a key differentiating factor in order to gain access to the market. Initially, this will require a Phase 1 feasibility study that will give us a clear direction for our demonstration and market introduction strategies. Later, based on proven feasibility, in the Phase 2 project we will gather the necessary documentation to reach regulatory approval, so Tensistat can be used in the manufacturing of medical and microfluidics devices. Still, we will demonstrate the technical and economic benefits of Tensistat in these segments, to generate enough consumer confidence and facilitate broader market uptake. If the objectives for Phase 1 and 2 are successfully achieved, we will be favourably positioned towards a very large opportunity for Jonsman Innovation. Accordingly, we foresee a cumulative revenue of more than €29.7 million, 5 years after commercialization of the Tensistat material.

Keywords: thermoplastic polymer,hydrophilic devices,medical devices,microfluidic devices
Applications and Fundamentals of Microresonator Frequency Combs (MICROCOMB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Spain,Germany,Germany,Switzerland,Belgium,Sweden,Sweden,Switzerland,Belgium,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 4038096.24
EU funding (EUR): 4038096.24
Participants: 17
Project status: CLOSED

The proposed network will establish and support cross-sectorial training and research programme bringing together leading European academic and industrial centers working in the area of optical frequency combs in microresonators (microcombs). The programme will allow to combine and share some of the world leading experience and expertise in the microcombs and train a new generation of scientists in this actively developing area bordering physics and photonic engineering and having pronounced applied and fundamental dimensions. The frequency comb research itself is the Nobel prize winning area (T. Hänsch and J. Hall, 2005), while the microcombs can qualify as an emerging disruptive technology. Europe still lacks a structured and comprehensive training programme in this area, which is proposed by our consortium, while facing a growing competiton with its global rivals. This programme will have a lasting impact increasing European innovation capacity through expanding knowledge base, new IP, trained personnel, better equipped laboratories and future collaborations leading to product development. Our project addresses research and technology problems with interdisciplinary importance from the areas of precision frequency metrology, ultrafast data processing, optical to RF signal conversion, astronomical measurements and soliton physics. Early stage researchers involved into the proposed network will receive broad and well balanced training in device characterisation and fabrication, experimental techniques and theory and modeling in best academic, research center and industrial environments. A programme of secondments and network wide events will ensure highest levels of cross-country and academia-industry mobility for our researchers. Soft-skills training events organised by such industrial consortium members as IBM, Menlo and AIRBUS will provide our researchers with career perspectives beyond their immediate research focus.

Keywords: frequency comb,nonlinear photonics,microresonator,optical soliton,metrology,optoelectronics
Foucault's manuscripts on phenomenology (1950s) at BnF archive: a digital approach to the edition (EDIFOU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

EDIFOU’s aim is to explore, organize, digitally index and disseminate Michel Foucault’s unpublished manuscripts of the 1950s and the early 1960s on phenomenology, psychology, psychopathology, and anthropology (collected since 2013 at the Bibliothèque Nationale de France Archive). This part of Foucault’s work is still totally unknown today, therefore EDIFOU aims to provide researchers with a new corpus, which is destined to become a reference work in the field of humanities. Together with proposing original theoretical analysis, EDIFOU meets the most current issues of digital humanities especially related to cultural heritage. EDIFOU has indeed the aims to achieve an original editorial program, and generate new knowledge by means of the development of innovative digital tools. As an external scientific consultant of Triangle’s ANR project 'Foucault Reading Notes', I have already tested the usefulness of the digital tools that have been developed in this framework up to now. EDIFOU’s aim is now to contribute to their improvement and further development. EDIFOU is highly stimulating and offers intellectual challenges. It is an ambitious project that requires not only specific scientific competences in the fields of philosophy, social sciences, and digital humanities, but also those personal and practical skills that enable a researcher to work in a team. At this stage of my career, I can rely on an excellent reputation in the international community of scholars in both the fields of Foucault studies, and history and philosophy of psychiatry. The quality of the research environment, supervision, training, and host facilities at Triangle-ENS de Lyon will give me the important opportunity not only to disseminate my research through diverse communication and outreach strategies, but also to profit from those skills, knowledge and training-related measures, which are fundamental to enhance my scientific independence and, as a consequence, my academic status.

Keywords: michel foucault,edition,phenomenology,psychopathology,anthropology,digital humanities,archive,manuscripts