Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy (Magicbullet Reloaded)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany,Italy,Italy,Germany,Germany,Italy,Germany,Switzerland,Finland,Hungary,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-04-30
Duration (months): 54.0
Total project cost (EUR): 3915902.88
EU funding (EUR): 3915902.88
Participants: 15
Project status: SIGNED

Despite the continuing development of new and more efficient treatments, cancer remains the second cause of premature death worldwide. Multi-faceted interdisciplinary research efforts in industry and academia on different aspects of cancer have provided a knowledge basis for the development of novel therapeutic approaches. Paul Ehrlich, Nobel laureate in Physiology of 1908, had the early vision that a compound could be made to selectively target a disease-causing organism or tumor. A toxin for the particular tissue could be delivered by an agent of selectivity. Such an ideal therapeutic agent would be a "magic bullet" that only kills the target cells. This ETN initiative with the title Magicbullet::reloaded refers to Ehrlich’s bold idea and builds on the previous experience of the highly successful ETN MAGICBULLET (2015-2018, grant agreement No. 642004). As a consequence of the outstanding results, the ETN Magicbullet::reloaded will expand the field of investigation from peptide-drug conjugates (PDCs) to small molecule-drug conjugates (SMDCs) with a special focus on drugs capable to stimulate tumor immune responses and overcome resistance to immuno-therapy. The consortium has been substantially expanded to perfectly address the needs of the new research direction. The planned ETN will design and synthesize an array of SMDCs (including PDCs), also targeting less investigated tumor antigens, investigate their pharmacokinetic behaviour, their implication on the immune system, as well as their tumor selectivity and antitumor activity. The consortium brings together interdisciplinary expert knowledge in Organic Chemistry, Peptide Chemistry, Medicinal Chemistry, Drug Discovery, Biochemistry, Pharmacology and Cell Biology. This high complementarity is required for the different scientific tasks in the development pipeline. Vice versa, the recruited ESRs will be exposed to a challenging research environment leading to a broad range of scientific competences to be acquired.

Keywords: small molecule drug conjugates peptide drug conjugates homing device cytotoxic drug natural products
Mind-wandering in everyday event comprehension: Memory, attention, and the brain (CPA-EST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 160465.2
EU funding (EUR): 160465.2
Participants: 2
Project status: CLOSED

Mind-wandering (MW) is the occurrence of thoughts that are decoupled from immediate perceptual inputs and unrelated to the activity at hand. MW represents a substantial part of our daily thinking time and it has substantial negative effects on reading, memory, and the ability to focus attention. At the same time, MW can enhance creativity and afford opportunities to plan for the future. However, most of what we currently know about MW comes from laboratory studies where the tasks from which the mind wanders are simple, boring, repetitive, and do not reflect the richness of daily life events. A limited body of research using experience sampling gives a coarse-grained characterization of MW in real-life situations, but this approach cannot measure the detailed behavioral structure of MW, or its neural correlates, to reveal underlying mechanisms. To overcome this barrier, we will leverage new advances in methods to study naturalistic event comprehension in the laboratory. We will adopt a multi-method approach that will combine (i) validated event cognition tasks that involve the viewing of movies of naturalistic everyday activities with (ii) state-of-the-art techniques to measure the behavioral, physiological, and neural correlates of MW. Study 1 will use eye-tracking to determine whether and how the event structure of naturalistic activities affects the perceptual decoupling component of MW. Study 2 will examine how the structure of everyday activities can modulate the content of MW episodes. Finally, Study 3 will use functional magnetic resonance imaging to investigate how the neural correlates of MW are modulated by the event structure of everyday activities. Together, these studies will provide the foundations for a detailed account of MW in naturalistic settings, laying the basis for future interventions aimed at helping individuals to capitalize on the benefits of MW in their daily life while minimizing the associated costs.

Keywords: functional magnetic resonance imaging,eye tracking,mind wandering,memory,experience sampling method,event cognition,self generated thought,naturalistic activities,attention
Ground states, symmetries and dynamics of quantum many-body lattice systems (QUANTLATTICE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2024-03-01
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

This project proposes a study of ground state phases of quantum lattice systems. The problem of detecting and describing quantum ground state phase transitions is a fundamental problem in the theory of quantum computing, where quantum information is stored in the ground state space of a many-body interaction. This study focuses on three avenues of research. The first is to investigate the stability of spectral gaps and the existence of symmetric invariants in 2D quantum spin systems. Such a program has already been carried out in frustration free models with local topological quantum order such as models with projected entangled pair ground states, but there remain important and open questions in more general models. The second direction is to study applications of quasi-adiabatic continuation methods to quantum lattice systems with unbounded Hamiltonians. These results would extend known results be applicable to models such as the quantum rotor and yield information about the adiabatic theorem in previously unknown cases. Lastly, the study focuses on propagation velocities and quasi-locality of many-body quantum dynamics.
Hybridizing Creative Writing Research: A Creatical Self-Portrait (CRESP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2024-12-31
Duration (months): 36.0
Total project cost (EUR): 319400.64
EU funding (EUR): 319400.64
Participants: 1
Project status: SIGNED

CRESP explores the eclectic discourses of nascent Creative Writing (CW) research, for the first time bringing together its practitioners from across language borders. This will serve to decolonialize a discipline currently dominated by the English language and introduce CW into the field of artistic research, in which it has been absent due to its monolingual orientation. My involvement in artistic research since 2010, my skills in ten languages as well as data collection, on-site networking and a multilingual video conference to be held during the fellowship will establish an international CW research network. Likewise, the project will help to push the world leading research of Lancaster’s Creative-Critical Writing (CCW) group beyond its current English-language orientation. Benefitting from the above cutting-edge expertise, I will research an amalgamated epistemic-aesthetic kind of writing that I term ‘creatical. My aim is to gain a better understanding of its discursive-stylistic workings, its manifestations in (un)controlled narration, its likely connections to second-language writing and its capacity to challenge existing orders. To this end, I will combine methods of 1) literary exegesis, 2) qualitative research and 3) literary practice in stages of hermeneutical progression. The resulting discourses – 1) metatextual writing, 2) polyphonic character speech and 3) stream of consciousness – will be merged into one creatical narrative. Knowledge-endowing insights emerging during its revisions will be displayed in a poetological cartography. Securing the expertise gained through the proposed research is particularly urgent since Creative Writing is now a fully recognized form of research in the UK, whose participation in European funding programs is uncertain as of 2021. Overall, the fellowship will strengthen Europe’s role as innovation leader by giving future Creative Writing researchers a head-start in a linguistically pluralistic culture of creatical writing.

Keywords: creative critical writing,creative writing,literary arts,literary writing,practice based literary research,practice led literary research
Inquiring gaps, discrepancies and contradictions in response to domestic gender-based violence. Gender relationships, practical norms and public services in Senegal. (INRES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Preventing and responding to domestic gender-based violence is a socio-cultural and political stake. Various public policies, including development ones, address this subject but if we consider their implementations several discrepancies, gaps and contradictions emerge. Focusing on Senegal, INRES is aimed at exploring the socio-cultural dynamics on which this phenomenon is grounded by sizing: a) the different representations of gender-based violence and of injustice in men’s behaviours towards women that circulate among pertinent distinct social actors (i.e. state officers, lawyers, NGOs personnel, women and, in a broader sense, citizens); b) how legal procedures and guidelines are effectively implemented in this domain, considering the practical norms that are deployed in divergence of official ones; c) which uninstitutionalised patterns of handling domestic gender-based violence are spread in the social arenas and the meanings that legitimate them. From a theoretical point of view INRES proposes an approach that combines in a seminal fashion different research fields of anthropology (of development and public polices, of law and of gender and kinship), integrating social history and gender studies and being committed with the purposes of a public anthropology.

Keywords: anthropology,public policies,west africa,gender based violence,anthropology of development
Cyclic nucleotide signalling in the human pathogen Listeria monocytogenes (a-Sign)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Nucleotides are the building blocks of nucleic acids and have emerged as significant determinants in energy transfer and signalling. Four nucleotides are known to function as signalling molecules in bacteria, namely the cyclic mono-nucleotides cAMP and cGMP, and the cyclic di-nucleotides c-di-AMP and c-di-GMP. These molecules play specific and distinct roles in many bacterial species, and can co-exist within a single bacterial cell. Whereas the diversity of cyclic nucleotide signalling is now starting to be uncovered, very little is known about their coordination in the control of their respective signalling pathways. Specifically, in the human pathogen Listeria monocytogenes, agent of a life-threatening and foodborne disease, it is known that both cyclic di-nucleotides c-di-AMP and c-di-GMP are produced but the production of cAMP and cGMP, as well as the contribution of the four nucleotides to the virulence mechanisms deployed by L. monocytogenes is yet to be uncovered. Using multidisciplinary approaches, the present proposal aims to 1) investigate the production of cAMP and cGMP, 2) identify new signalling pathways governed by the different cyclic nucleotides, and 3) uncover their role in physiology and pathogenesis. The overall impact of this proposal can open up the field to novel concepts and provide a basis for the study of cyclic nucleotide crosstalk.

Keywords: signalling,bacteria,cyclic nucleotides,listeria,pathogenesis
Circuit mechanisms of self-movement estimation during walking (activeFly)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-11-01
End date: 2023-12-31
Duration (months): 74.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The brain evolves, develops, and operates in the context of animal movements. As a consequence, fundamental brain functions such as spatial perception and motor control critically depend on the precise knowledge of the ongoing body motion. An accurate internal estimate of self-movement is thought to emerge from sensorimotor integration; nonetheless, which circuits perform this internal estimation, and exactly how motor-sensory coordination is implemented within these circuits are basic questions that remain to be poorly understood. There is growing evidence suggesting that, during locomotion, motor-related and visual signals interact at early stages of visual processing. In mammals, however, it is not clear what the function of this interaction is. Recently, we have shown that a population of Drosophila optic-flow processing neurons —neurons that are sensitive to self-generated visual flow, receives convergent visual and walking-related signals to form a faithful representation of the fly’s walking movements. Leveraging from these results, and combining quantitative analysis of behavior with physiology, optogenetics, and modelling, we propose to investigate circuit mechanisms of self-movement estimation during walking. We will:1) use cell specific manipulations to identify what cells are necessary to generate the motor-related activity in the population of visual neurons, 2) record from the identified neurons and correlate their activity with specific locomotor parameters, and 3) perturb the activity of different cell-types within the identified circuits to test their role in the dynamics of the visual neurons, and on the fly’s walking behavior. These experiments will establish unprecedented causal relationships among neural activity, the formation of an internal representation, and locomotor control. The identified sensorimotor principles will establish a framework that can be tested in other scenarios or animal systems with implications both in health and disease.

Keywords: sensory motor integration,drosophila,locomotion,optogenetics,calcium imaging,electrophysiology,motion vision
Pre-Commercial Procurement of Innovative Triage Management Systems Strengthening Resilience and Interoperability of Emergency Medical Services (iProcureSecurity PCP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Pre-Commercial Procurement
Countries involved: Austria,Spain,Italy,Spain,Italy,Italy,Germany,Greece,Türkiye
Call: Strategic pre-commercial procurements of innovative, advanced systems to support security (H2020-SU-SEC-2020, 2020)
Start date: 2021-09-01
End date: 2024-10-31
Duration (months): 38.0
Total project cost (EUR): 11998660.0
EU funding (EUR): 10798794.0
Participants: 14
Project status: SIGNED

Emergency Medical Services (EMS) in Europe are characterised by a heterogeneous landscape with diverse organisational setups, technology standards, coordination mechanisms and actors. This is the result of different historical and institutional contexts. However, these EMS are united by the common aim of providing timely care to victims of sudden and life-threatening emergencies or disasters in cross-border settings and international humanitarian missions. Fostering the response capacities and increasing the cooperation of the Emergency Medical Services Systems (EMSS) is of decisive importance for strengthening the resilience of European societies. During the prior iProcureSecurity project, a large number of EMS were involved to identify, evaluate and prioritise future challenges and needs. The creation of an interoperable, flexible triage management system supported by modern technologies was among the most requested solutions in the context of security-related scenarios. This iProcureSecurity PCP action is a result of those intense participatory consultation processes. The action will lead to an innovative triage management system that provides a) quick and accurate overview of victims and their status; b) decision support for better allocation of available resources and quicker support for patients; c) improved interoperability with other first responders and relevant actors; d) reduced handover times between ambulance transport and hospitals; and e) insights for quality assurance and training measures. Following the EC Guidelines on Pre-Commercial Procurement (PCP), through a competitive series of design, prototype and pilot steps, the iProcureSecurity PCP will contract suppliers to deliver the creation and deployment of the envisaged triage management system. Besides the buyers within the consortium, additional observers and experts will participate to contribute to the Pan-European improvement in this field and to proactively share PCP knowledge.

Keywords: triage management systems,resilience,interoperability,emergency medical services,innovation procurement,innovative tender system
Disrupting fine chemicals manufacturing with catalyst-coated tube reactors (Stoli Catalysts)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-07-01
End date: 2022-06-30
Duration (months): 36.0
Total project cost (EUR): 1682750.0
EU funding (EUR): 1177925.0
Participants: 1
Project status: CLOSED

Stoli Catalysts Ltd is an innovative UK award-winning innovative SME, a spin-out of University of Warwick (UoW). Our team comprises of leading academics in the field of reaction engineering and catalysis led by CEO with significant commercial experience and supported by two industrial experts. Stoli Catalysts patented catalyst coating technology has the potential to halve the manufacturing costs across the Fine Chemicals industry. It delivers high mass and heat transfer rates in reactions providing higher reactor utilization and efficiency promising to disrupt this industry. Stoli Catalysts’s coating technology can be applied to a wide range of catalysts covering more than 90% of the needs of fine chemicals industry. The initial addressable market of €317 M comprises manufacturers of fine chemicals (nutraceuticals, agrochemicals &amp; speciality chemicals). Professor Evgeny Rebrov (founder) was awarded with 2 ERC grants, totalling €1,400,000, to develop, validate, perform the feasibility study and demonstrate the market potential of his ground-breaking technology: ERC Starting Grant 279867–RFMiFiCS “RF-enhanced micro processing for the fine chemicals synthesis using catalysts supported on magnetic nanoparticles” and ERC Proof of Concept 693739–MiCARF “Multi-tubular Catalytic Reactor for Flexible Production of Fine Chemicals”. Stoli Catalysts was supported to date by the Business Ready program of the UoW Science Park and funding from Innovate UK, Warwick Ventures, Mercia Technologies PLC as well as from direct product sales, in-kind contribution from industrial partners (DSM and Vapourtec) and consultancy projects. The two ERC projects brought the innovation to TRL 7, and after obtaining promising results from the feasibility study, we are applying for the SME Instrument PH2 funding to scale up the technology in the industrial environment and reach TRL9.

Keywords: catalyst coating technology,game changing flow design,fine chemical processing,automation,process,control,high reactor utilization,reactor scale up,continuous flow manufacturing,hydrogenation