Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
First Scalable Field-Programmable Photonic Gate Array Platform For Photonic Chip Development and Data Centre Switch Applications (EXCITE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Spain
Call: Enabling the smart edge (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 3489289.89
EU funding (EUR): 2442502.92
Participants: 1
Project status: SIGNED

Data traffic, compute load and signal processing requirements have grown exponentially in recent decades. However, the performance increases of conventional electronics are no longer adequate to keep up with these increasing demands as Moore’s Law is ending. Photonic Integrated Circuits (PICs), harnessing photons instead of electrons to manipulate signals, are widely regarded as the technology of choice to power the next-generation of high performance devices. PICs are commercially available in the form of ASPICs (application-specific photonic integrated circuits). However, with internal circuitry fixed during fabrication they are limited to very specific tasks and are extremely time-consuming and expensive to develop. They are therefore only suitable for extremely high-volume applications. There is an urgent need for an affordable, flexible, reprogrammable alternative to ASPICs, with the same performance benefits, an approach similar to Field Programmable Gate Arrays (FPGAs) in conventional electronics. The Field Programmable Photonic Gate Arrays (FPPGAs) we develop are a completely new class of devices that will fundamentally change the economics of ASPIC design. FPPGAs can typically save 90% of the development time and 95% of tape-out costs by testing ASPIC designs inside FPPGAs before production without further iterations, eliminating vast inefficiencies. The flexible on-chip optical signal routing also unlocks novel features like self-optimising circuitry and self-healing properties. This project, EXCITE, will refine, demonstrate and scale up the world’s first commercially-viable FPPGAs as a general-purpose platform technology and make it accessible to the wider developer community. Following on from the successful EIC Transition project INSPIRE, iPronics will now optimise this development platform for mass-manufacturing and demonstrate its benefits in a first application area, data switches for optical signal switching in large data centres.

Keywords: programmable photonic circuits prototyping novel optical functionalities accelerated optical signal switching for data centre interconnect dci applications smart edge quantum computing
Bringing Nanotechnology-based Innovation to Patients with Chronic Wounds (CURE2MARKET)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: EU prize
Destination: EU Prize for Women Innovators
Action type: Recognition Prize
Countries involved: Estonia
Call: Horizon-EIT-2024-Prize-EPWI-WomenLeadership (HORIZON-EIT-2024-WomenInnovatorsPrize, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

We are solving the problem of chronic wounds that cause amputations and mortality rates similar to those of cancer. With our innovation, we aim to reduce amputations and mortality caused by chronic wounds by 50%. We already have clinical proof that our technology removes infections 8 times better and cures wounds that other methods can not cure. Our research started from a personal problem - my grandmother was suffering from chronic wounds for several years, and available treatments did not work. The main problem causing not healing was reoccurring wound infections that is the most common complication for chronic wounds. 10 mln amputations occur annually worldwide because of wound infections, and one-third of patients die within 5 years after amputation. In 2016, I established my research group to develop antibacterial nanotechnology aiming to cope with infection. In 2019, I co-founded Nanordica Medical to bring our nanotechnology from the lab to the market and help hundreds of millions of patients with chronic wounds. In 2022-2023, we were awarded WomenTech EU, EIT Health Innostars, and EIC Accelerator grants that enabled us to conduct a first-in-man trial, demonstrate the efficacy of our solution on patients with diabetic foot ulcers and establish regulatory and commercialization roadmaps. With the current proposal, we aim to bring our product to the market. More specifically, the main aims are: 1) to gain market authorization for our solution and 2) to launch our solution in selected countries. Because of regulatory requirements, we currently can not sell or freely distribute our product that can save lives. Thus, achieving these aims would bring our solution to patients with chronic wounds and help improve the lives of hundreds of millions of people. Not least, the breakthrough in medicine we are doing is unique to our small country, Estonia, and our women-led company is an expiring example for women and girls.
In situ monitoring of the toxicological evolution of nanoplastics in living organisms (CFENPLs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Nanoplastics (NPLs) are one of the most hazardous emerging environmental pollutants. We nevertheless still have a limited understanding of the precise toxicological mechanisms in living organisms. Herein, we propose a miniaturized electrochemical sensing platform combined with single-cell techniques to simultaneously and dynamically monitor the concentration of NPLs ingested by a single cell that is actually causing adverse effect and the release of toxicological markers (such as H2O2, H2S or specific DNA/RNA) from cellular damage. The implementation of this project is based on the innovation of the preparation technology of carbon-based microelectrodes functionalized with alkyl chain monolayer and recognition sites, which for the first time will be simultaneously integrated with single-cell analytical techniques for environmental risk assessment. Investigating the toxicology of NPLs at the single-cell level can avoid obtaining only the average expression of a population of cells and ignoring intracellular heterogeneity. Meanwhile, the toxicological concentration of NPLs and the type and concentration of toxicological markers will be efficiently matched, screened and quantified using machine learning, which can provide a phased and hierarchical understanding of the mechanism of toxicity evolution of NPLs in individual cells, and thus provide accurate references for the prediction of and early warning on the toxic effects of NPLs on living organisms. The development of this interdisciplinary technique is expected to not only broaden the understanding of the hazards of NPLs and reveal the evolutionary process of toxicity caused by NPLs, but will also provide an analytical platform for toxicological assessment of other types of pollutants. Moreover, it is promising to promote the commercialization of a portable device for the rapid detection of NPLs in water samples, which will provide a powerful tool for environmental protection and household water quality monitoring.

Keywords: electrochemical sensing,living organism,toxicological concentration,nanoplastics,toxicological markers
Machine Learning-Assisted simulation of Metalloenzyme’s Reactivity (MALAMER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 2
Project status: SIGNED

Metalloenzymes play a crucial role in various biological functions, going from small molecule transportation to catalyzing essential metabolic ingredients. Understanding their reactivity is essential for advancing a broad range of fields and related industries, such as medicine, biotechnology, environmental science, and catalysis. The computational modelling of biomolecules is a pillar of new drug and catalyst design, but the common methods used for purely organic-based compounds, such as empirical force fields, cannot simply be applied in the presence of a metal centre due to their complex electronic structure. On the other hand, hybrid Quantum Mechanical/Molecular Mechanics (QM/MM) methods provide a way to study metalloenzymes, but their computational overheads prevent their large-scale use for molecular dynamics simulations and reactivity studies. The project MAchine Learning-Assisted simulation of MEtalloenzyme’s Reactivity (MALAMER), aims to revolutionize the simulation of metalloenzymes' reactivity by integrating machine-learning force fields with QM/MM methods, and advanced sampling techniques, allowing for an unprecedentedly accurate description of their activity. This innovative approach will lead to significant insights and applications in catalyst development and drug discovery, with a potential impact on several EU priority areas. The project will commence in September 2024 under the supervision of Prof. Lunghi at Trinity College Dublin, with a planned 3-month secondment at University College London to gain additional expertise in advanced sampling simulations from Prof. Salvalaglio. A comprehensive set of training, dissemination, exploitation, and communication activities are planned and they will be implemented with the help of the supervisors and Trinity College Dublin's human resources, training office, and innovation and technology transfer office.

Keywords: computational chemistry bioinorganic chemistry enzyme catalysis,machine learning force fields,molecular dynamics
The role of Palmitoylation ERASERs in cancer metastasis (PalmERASERs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1495519.0
EU funding (EUR): 1495519.0
Participants: 1
Project status: SIGNED

Metastasis is the major cause of death in patients with cancer. A better understanding of the mechanisms driving metastasis is critical to develop more effective anti-cancer treatments. The fatty acid palmitate has been recently identified as fuel for metastasis-promoting pathways. However, why palmitate has such a unique pro-metastatic effect compared to other fatty acids with similar metabolic fates remains elusive. Strikingly, I discovered that palmitoylation, a reversible post-translational protein modification driven solely by palmitate, is essential for metastasizing breast-cancer cells. Unexpectedly, I found that palmitoylation ‘erasers’, enzymes that remove the modification, are essential to sustain pro-metastatic effects of palmitate during metastatic colonization. Therefore, I hypothesize that, in palmitate-rich conditions (e.g under high-fat diet), palmitoylation anchor oncogenic proteins to membranes to get activated (functioning as a priming event), while erasers act as a rate-limiting release step, allowing primed proteins to engage in pro-metastatic signaling. I will investigate how the dynamics of palmitoylation promote metastasis by focusing on the erasers, whose role in metastasis remains largely unexplored. Specifically, I will: 1) define how erasers influence pro-metastatic signaling events in metastasizing cells; 2) investigate how erasers activity is regulated in metastasizing cells; and 3) assess how organ microenvironments and palmitate-rich diet condition eraser activity. I will address this by integrating multi-omics, molecular biology and mass spectrometry techniques with clinically relevant in vivo metastasis models. PalmERASERs will serve as a proof of concept for palmitoylation-based therapies with the goal of preventing or treating metastases. By focusing on the influence of diet, I will also enhance clinical translation of these findings by defining which patients will respond most effectively to palmitoylation-based therapies.

Keywords: metastasis,post translational modifications,palmitoylation,palmitate metabolism,breast cancer,high fat diet,anti metastatic therapies
Stochastic Rewind and fast-forward: calibrating LISA with LIGO's black holes and stochastic background (StochRewind)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

The direct detection of gravitational waves from binary stellar-mass black hole systems in our Universe provides a wealth of astrophysical information which is now within our reach. These binaries merge in the LIGO and Virgo detector frequency sensitivity bands, and were once sweeping through the LISA band, emitting at much lower frequencies. In LIGO, the binary mergers appear both as single, resolved events and as a multitude of incoherent signals, known as the stochastic gravitational-wave background. In LISA, a similar picture will be seen, where a few binaries are directly resolved, while the vast majority build up a stochastic signal. With StochRewind, we will draw out all binary black hole information measured by LIGO and Virgo to calibrate the LISA mission, providing a crucial ingredient for LISA data analysis methods. First, we focus on the stochastic background in LIGO, and deliver a brand new pipeline which maximises our chances for detection. Then, we analyse the implications of the LIGO black hole detections and stochastic background for LISA, delivering the first data-based prediction of the LISA binary black hole stochastic background, fully exploiting our multi-band gravitational-wave knowledge. It is essential that StochRewind be hosted by an institute which can supplement the fellow's first-hand experience in stochastic LIGO data analysis with knowledge on black hole population analysis and LISA astrophysics. UniMiB is a unique institution which counts top experts in both these fields, providing an environment which bridges the gap between LISA and LIGO. These revolutionary science objectives will be paired with advanced training objectives tailored to the fellow's personal career development plan, rooted in what UniMiB and the collaborations have to offer. StochRewind will have far-reaching impacts on the community, which will reap the benefits for decades to come.

Keywords: gravitational waves,gravitational wave background,binary black holes,stochastic searches,ligo,lisa
Understanding the top-down and bottom-up development of emotional styles in a modern colonial context: The case of the Jewish community in Mandatory Palestine (ColEMP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2026-07-31
Duration (months): 36.0
Total project cost (EUR): 294833.28
EU funding (EUR): 294833.28
Participants: 2
Project status: SIGNED

How do emotional styles develop in colonial settings? What are their roles in the construction of settler identities? Such processes happen both “from below”—in the daily and often casual behavior of ordinary men, women, and children; and “from above”—in discourses about the ideal and actual characteristics of a settler. As the early Zionists, looking to execute their national project in the colonial world, fully realized, a colony, regardless of its function, always provides an opportunity to produce “new people.” In the case of the Yishuv—the Jewish community that coalesced in Mandatory Palestine—the top-down direction of this process can be identified in the extensive Zionist literature about the desired “New Jew” as well as in the attempts to embed his or her traits using printed matter (such as parents’ manuals and children’s literature). Drawing on this feature of the Yishuv, the research analyzes both the Zionist project of top-down emotional transformation and the actual expression and experiences of emotions in the burgeoning settler society. By integrating these two levels, the research goes beyond the existing scholarship, which usually focuses on one or the other, and breaks new ground in understanding how emotions were mobilized and how new emotional styles emerged in a colonial context. The outgoing phase, which will last two years at Harvard University, under the supervision of Prof. Derek Penslar, has two aims: (i) to understand how the colonial context (within which early Zionism operated) impacted ideas about new emotional styles; and (ii) to survey the attempts to bring these ideas into the homes of (the mostly European) settlers at the time. The incoming phase, running one year at Bar-Ilan University, under the supervision of Prof. Hizky Shoham, will assess the impact—or lack thereof—of the emotional transformation studied in the outgoing phase on the everyday emotional practices of families in the mainstream urban sector of the Yishuv.

Keywords: emotions,history,colonialism,settler colonialism,mandatory palestine,zionism,family,immigration,nationalism,children,parents,generations
National engagement activities to support the launch of the Mission 'A Soil Deal for Europe’ 100 Living Labs and Lighthouses (NATI00NS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Coordination and support actions
Countries involved: Denmark,Belgium,Spain,Italy,Lithuania,Romania,Tunisia,Sweden,Serbia,Poland,Hungary
Call: National engagement sessions and support to the establishment of soil health living labs (HORIZON-MISS-2021-SOIL-02, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 2999084.25
EU funding (EUR): 2999084.25
Participants: 14
Project status: CLOSED

NATI00NS will assist the EU Mission 'A Soil Deal for Europe’ during most of its first "induction and pilot" phase (2021 – 2025), acting as a messenger and conveying awareness-raising messages to national and regional stakeholders, providing access to capacity building materials and information, spurring the discussions on the best Living-Lab (LL) setups to address regional soil needs, and fostering early matchmaking for cross-regional LL clusters. Eventually, the smooth execution of the project will be reflected in the number of high-quality applications received in the first open calls and the funding of the first two waves of LL projects, which can lead the way for the systemic change boosted by the Soil Mission. The takeaways will be also useful for upcoming activities in the Soil Mission's second "expansion and innovation" phase (2025 – 2030) when the rest of the waves of LLs will be selected. NATI00NS' consortium has been carefully selected and formed with the intention of gathering and covering all the necessary expertise needed to ensure the successful execution of the work plan and achievement of the project's objectives. This will, in turn, allow the partners to contribute to the Soil Mission’s expected impact on society, following the achievement of its objectives and goal. On the one hand, the project is counting on top experts on soil science and the co-participatory place-based innovation approaches to be put in place in the Living Labs. On the other hand, NATI00NS is granting adequate national outreach in all EU Member States and Horizon Europe Associated Countries through its 14 partners, its Key network group representatives and all their networks (i.e., BIOEAST, European Network of Living Labs, Soil Health National Hubs, ERIAFF, etc.).

Keywords: randi missions,soil deal,soil health,living lab,lighthouse,knowledge,awareness
Improving yields in organic cropping systems (OrganicYieldsUP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Coordination and support actions
Countries involved: Belgium,Portugal,Italy,Estonia,Luxembourg,Denmark,Sweden,France,Poland,Hungary,Germany,Spain,Switzerland
Call: Improving yields in organic cropping systems (HORIZON-CL6-2023-FARM2FORK-01, 2023)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 3636196.53
EU funding (EUR): 3557821.53
Participants: 17
Project status: SIGNED

With the European Green Deal, the Farm-to-Fork and Biodiversity Strategy, the EU aims to achieve the target of at least 25% of the EU’s agricultural land under organic farming by 2030. This means tripling the current organic farm area with estimated 700.000 farmers expected to enter the organic sector. One of the obstacles hindering conversion to organic farming is the lower yields per hectare grown under organic conditions as compared with those produced under conventional farming. Therefore, improving organic yields is a key challenge of the organic sector, which however needs to be achieved on the basis of the principles of organic farming. Against this background, the overall aim of the project is to contribute to a sustainable increase in yields in organic cropping systems through a comprehensive and structured compilation and evaluation of existing knowledge, devising sustainable impact strategies relevant to stakeholders and policy. The project will set up an European-wide network of testing, experimentation and demonstration sites from 11 regions / countries, representing a wide range of pedo-climatic and structural conditions. It will connect actors from science and practice to jointly reflect on organic yield increase strategies. It will draw recommendations for the future research agenda and development of EU policies relevant for organic production. The outcomes of the project will be widely available and disseminated to actors within and beyond the organic community.

Keywords: yield increase strategies,yield improvement,research and innovation workplan,akis,policy support,data and knowledge