Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative,multi-applicable-cost efficient hybrid solar (55%)and biomass energy(45%) large scale (district) heating system with long term heat storage and organic Rankine cycle electricity production (SUNSTORE 4)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewables for heating and cooling
Action type: Collaborative project
Countries involved: Germany,Sweden,Austria,Italy,Denmark,Denmark,Denmark,Belgium,Czechia
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 15102351.0
EU funding (EUR): 6127548.25
Participants: 11
Project status: CLOSED

The overall objectives of the project are to demonstrate a &quot;SUNSTORE 4&quot; energy concept of a large scale innovative cost efficient, and technical reliable 100% renewable energy supply system for a (Marstal, DK) large scale (district) heating system with yearly heating production of 28,000 MWh - based on 55% solar energy and 45% biomass energy (willow wood chips from energy crops) including a CO2 heat pump and electricity production from biomass energy through an Organic Rankine Cycle (ORC) unit. The plant comprise:15,000 m2 solar system, CHP system with a low emission 4.0 MW wood chips thermal oil boiler and a 750 kWel ORC; 75,000 m3 pit heat storage, 1.5 MW (thermal) CO2 –driven heat pump - supplementing the existing demonstration plant (SUNSTORE 2) including 18,300 m2 solar thermal and 10,340 m3 pilot pit storage.The targets on cost efficiency are for solar thermal to meet the vision of ESTTP with a cost of 3-6 €-cent per kWh, total energy production costs of 78 Euro/MWhthermal and (low) investment costs of 33 Euro/m3 of the pit heat long term storage. Flexibility in energy output has been obtained through including ORC and the heat pump. The capacity of the pit heat storage has been increased through innovative application of the heat pump. Other types of SUNSTORE 4-energy concepts will be developed adapted to the regional conditions of energy loads, energy costs, renewable energy sources etc. in regions of Eastern, Southern, Central and Northern-Western EU. Dissemination activities will be carried out in 10 EU-countries with short term impact with an indicative target of 20 systems in AT-CZ-DK-FR-DE-IT-PL-ES-UK. The medium (2020) and long time impacts are indicative targets of 0.9-1.8 GWth and 5-10 GWth. The SUNSTORE 4-team comprise European leading experts as J.O. Dalenbäck (Chalmers University), D. Mangold/T. Schmidt (Solites), R. Obernosterer-I. Obernberger (BIOS), R. Battisti (Ambiente Italia) and P.A. Sörensen (PlanEnergi)

Keywords: 100% renewable large scale heating,>50% solar thermal and biomass,low cost and flexible pit long term heat storage with heat pump,organic rankine cycle,big flexibility in energy outputs
Large Scale Tool for Power Balancing in Electric Grid (LASTBEG)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Smart energy networks
Action type: Collaborative project
Countries involved: France,Lithuania,United Kingdom,Germany,Spain,Spain,Lithuania,Spain,Hungary,United Kingdom
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 10114451.0
EU funding (EUR): 6187246.0
Participants: 10
Project status: CLOSED

This project will demonstrate an optimisation of renewable energy supplies, primarily onshore and offshore, with an existing pumped storage power plant (PSPP). It will integrate smart meters with power demand and supply forecasting to enable consistent power supply from the TSO in Lithuania. Lessons from this demonstration will be disseminated directly to the project partners and indirectly to other major TSOs. This work will enable a greater penetration of RES to help meet the 20:20:20 objectives. This project will not involve high level R&amp;D rather it will involve the demonstration and scale up of previous high quality European and national R&amp;D at a country-wide level. It will adapt and integrate existing hardware and software systems for the smart application of RES to national and ultimately pan-EU grids. It will valorize an existing PSPP in Lithuania in need of significant enhancement to enable it to buffer 200MW of wind power. This demonstration and implementation will be on a scale that is transferable and replicable on larger grids. It will be achievable within a period of 48 months. The project objectives will meet the call objectives: 1. Successful demonstration of the integration of over 200MW RES (wind-based) with PSPP and smart meters, to enable consistent and reliable matching of supply with demand. 2. Adaptation of PSPP to enable balancing of 200MW wind sourced RES 3. Adaptation of PSPP output with existing planning, demand and generation forecasting tools, and grid management tools. 4. Installation of advanced smart meters with 5,000 customers for testing of the integrated LASTBEG system. 5. Demonstration of web-based remote power monitoring and control. 6. Adaptation of advanced mathematical models to enable predictive power balancing. 7. Adaptation of network grid balancing tools to enable Distributed Energy Resource integration. 8. Demonstration of the cost-optimised integrated system in Lithuania for wider trans-EU dissemination

Keywords: wind energy generation pumped storage grid balancing and optimisation
Optogenetic Neural stimulation platform (OPTONEURO)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Collaborative project
Countries involved: United Kingdom,Ireland,Germany,Switzerland,United Kingdom,United Kingdom
Call:  (FP7-ICT-2009-C, 2009)
Start date: 2010-10-01
End date: 2014-03-31
Duration (months): 42.0
Total project cost (EUR): 2941024.0
EU funding (EUR): 2190000.0
Participants: 7
Project status: CLOSED

The 2003 breakthrough discovery of a nanoscale optically active cation channel, channelrhodopsin-2, made it possible for the first time, to genetically re-engineer neuron cells to be photosensitive. It became possible to stimulate or inhibit individual action potentials at will, without further chemical modification. The capabilities have been demonstrated in a number of recent high profile journals detailing optical-neural control from cell culture to primate models. The light-gated cation channels were discovered and first applied by European researchers. The photonics and optoelectronics sectors, which can provide new stimulation technologies to this field, are additionally, European strengths. Nevertheless, in recent years, the dominant research output in this area has shifted to well-funded US laboratories. This proposal therefore aims to create a consortium to develop an array of ultra bright electronically controlled microLEDs which will provide a truly revolutionary tool for the neuroscience and neurotechnology community. The consortium consists of experts in the field who converge the many disciplines (optics, sophisticated LED fabrication, CMOS flip chip design and bonding, biophysics, molecular biology, neurophysiology) to bear on the complex, and crucial to neuroscience, problem of studying dendritic physiology and neural network dynamics. Advances in the techniques of this field will absolutely be required to further our understanding of brain function. The system we propose to develop will be powerful, sophisticated and at the same time, lead to a commercial spin-out that will provide them at relatively low cost. In the longer term, the tools we develop in this proposal will hasten our long term aims of developing an optogenetic retinal prosthesis.

Keywords: neuron,neuron network,gan,led,micro led neural stimulation,retinal prosthesis,channelrhodopsin,chr2,chop2,cmos,aer,flip chip
Derived and Ancestral RNAs: Comparative Genomics and Evolution of ncRNAs (DARCGENS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: United Kingdom,United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-05-01
End date: 2015-04-30
Duration (months): 60.0
Total project cost (EUR): 2400000.0
EU funding (EUR): 2400000.0
Participants: 2
Project status: CLOSED

Much light has been shed on the number, mechanisms and functions of protein-coding genes in the human genome. In comparison, we know almost nothing about the origins and mechanisms of the functional dark matter , including sequence that is transcribed outside of protein-coding gene loci. This interdisciplinary proposal will capitalize on new theoretical and experimental opportunities to establish the extent by which long non-coding RNAs contribute to mammalian and fruit fly biology. Since 2001, the Ponting group has pioneered the comparative analysis of protein-coding genes across the amniotes and Drosophilids within many international genome sequencing consortia. This Advanced Grant will break new ground by applying these approaches to long intergenic non-coding RNA (lincRNA) genes from mammals to birds and to flies. The Grant will allow Ponting to free himself of the constraints normally associated with in silico analyses by analysing lincRNAs in vitro and in vivo. The integration of computational and experimental approaches for lincRNAs from across the metazoan tree provides a powerful new toolkit for elucidating the origins and biological roles of these enigmatic molecules. Catalogues of lincRNA loci will be built for human, mouse, fruit fly, zebrafinch, chicken and Aplysia by exploiting data from next-generation sequencing technologies. This will immediately provide a new perspective on how these loci arise, evolve and function, including whether their orthologues are apparent across diverse species. Using new evidence that lincRNA loci act in cis with neighbouring protein-coding loci, we will determine lincRNA mechanisms and will establish the consequences of lincRNA knock-down, knock-out and over-expression in mouse, chick and fruitfly.

Keywords: comparative genomics transcription regulation translation regulation rna evolution
DISSECTING GENETIC DEPENDENCIES IN CANCER (FUNCTIONAL GENOMICS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: Netherlands
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2015-05-31
Duration (months): 60.0
Total project cost (EUR): 2176000.0
EU funding (EUR): 2176000.0
Participants: 1
Project status: CLOSED

While significant progress has been made in the diagnosis and treatment of cancer, several major issues remain unresolved. First, only a minority of patients respond to most forms of (chemo)therapy. It is generally believed that this poor responsiveness to drugs has its origin, at least in part, in the molecular heterogeneity of cancer. This heterogeneity requires the use of biomarkers to stratify patients having seemingly similar tumors according to their likely responses to specific cancer therapies. To identify such biomarkers, we will use large-scale genetic screens to identify genes that are causally involved in controlling responses to cancer drugs. Such genes are likely biomarkers of drug responsiveness in the clinic. Availability of such drug response biomarkers will facilitate a more personalized therapy choice for each individual patient. A second major deficit in effective cancer therapy is the lack of sufficient highly selective drug targets. The large-scale cancer genome re-sequencing efforts already indicate that there is a paucity of druggable genes that are consistently mutated in cancer and the same holds true for genes that are consistently over-expressed in cancer. Hence, there is an urgent need for innovative drug targets that have a similar cancer-selectivity as the genes that are specifically mutated or over-expressed in cancer. In this project, we will use large-scale loss of function genetic screens, exploiting the concept of synthetic lethality , to identify genes whose inactivation is selectively toxic to cells having a defined cancer-specific genetic alteration. Drugs against these targets will be highly cancer-selective, as their activity hinges on the presence of a specific genetic defect, which is only present in the cancer cell.

Keywords: functional genomics,biomarkers,rna interference,genetic screens
Terahertz room-temperature integrated parametric source (TREASURE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Collaborative project
Countries involved: France,Germany,Denmark,Switzerland
Call:  (FP7-ICT-2009-C, 2009)
Start date: 2010-05-01
End date: 2013-04-30
Duration (months): 36.0
Total project cost (EUR): 2309298.0
EU funding (EUR): 1706000.0
Participants: 5
Project status: CLOSED

This project will demonstrate an integrated terahertz (THz) emitter at room temperature, based on a parametric optical process in an AlGaAs device, combining strong material nonlinearity and high optical confinement. The approach followed is based on a quasi-phasematching scheme in the whispering-gallery cavity of a microcylinder containing self-assembled quantum-dots. Compared to existing THz sources like photoconductive antennas, photo-mixers, quantum cascade lasers and optical parametric generators, the TREASURE source will bring together several crucial advantages: room-temperature operation, electrical pumping, compactness, THz power above ~0.3 µW from a single emitter (1 µW in an array) , custom emission wavelength, spectral purity, an the perspectives of coherent detection and two-dimensional array schemes. This will be accomplished with the complementary competences of four world-class research groups, plus an industrial partner, leader in the THz technology.

Keywords: quantum-dot laser,whispering gallery modes,nonlinear optics,terahertz generation,microcavity,dfg,phase matching
Signalling within the mammalian circadian timing system (TIMESIGNAL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Switzerland
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-04-01
End date: 2015-12-31
Duration (months): 69.0
Total project cost (EUR): 2360136.0
EU funding (EUR): 2360136.0
Participants: 1
Project status: CLOSED

The main objective of this interdisciplinary research project is to elucidate regulatory mechanisms through which the circadian timing system coordinates temporal physiology. This system has a hierarchical architecture, in that a master clock in the brain s suprachiasmatic nucleus synchronizes subsidiary oscillators in nearly all body cells. The establishment of phase coherence is obviously of utmost importance in the coordination of circadian physiology. While recent studies have identified feeding cycles, hormone rhythms, and body temperature oscillations as timing cues for peripheral clocks, the molecular makeup of the involved signalling mechanisms is largely unknown. Using liver and cultured cells as model systems, we will employ two innovative strategies for the elucidation of relevant signalling pathways. (1) STAR-Prom (Synthetic TAndem Repeat-PROmoter display), a technique developed in our laboratory, will hopefully identify most if not all immediate early transcription factors activated in cultured cells by rhythmic blood-borne and temperature-dependent signals. (2) A transgenic mouse model with conditionally active liver clocks will be explored in the genome-wide identification of coding and non-coding transcripts whose rhythmic accumulation is system-driven. The in vivo significance of the components emerging from these approaches will be assessed via RNA interference. Thus, relevant siRNAs will be injected into the tail vein of mice, and their effect on the phase of circadian liver gene expression will be monitored in freely moving mice by using whole body fluorescence imaging. Physiologically important components will serve as entry points for the identification of upstream and downstream constituents in the corresponding signal transduction cascades.

Keywords: circadian clock,immediate early genes,phase coherence,ultradeep sequencing,liver
Molecular basis of carnivory Excitability, movement, and endocrinology of plant traps (CARNIVOROM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Germany
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-03-01
End date: 2015-02-28
Duration (months): 60.0
Total project cost (EUR): 2481057.0
EU funding (EUR): 2481057.0
Participants: 1
Project status: CLOSED

Predation plays a major role in energy and nutrient flow in the biological food chain. Carnivory is best known from the animal kingdom, but the plant kingdom has flesh eaters as well. This field has attracted much interest since Darwin s time, but many fundamental properties of the carnivorous life style remain largely unexplored. This project will close this gap by a multidisciplinary approach based on state-of-art bioinformatics, molecular biology, chemistry and biophysics. It will focus on 1. Genome/Transcriptome Profiling to study the genetic make-up of carnivorous plants (CPs) and the evolution of carnivory 2. Origin of Excitability to investigate whether CPs gained the inventory to fire action potentials from captured animals or rather evolved excitability independently 3. Prey Recognition on the basis of mechanical- and chemical senses 4. Endocrinology Structure and function of exocrine glands - CPs offer a unique system to study the biology of digestive glands (exo-/endocytosis) in plants. Over 600 plant species use special structures to capture animals such as insects. The genome/transcriptome of major trap types such as snap traps, tentacles traps, suction traps, corkscrew traps, and pitfall traps will be compared and trap-specific genes identified. Among them those giving rise to membrane excitation, excitation-contraction coupling and exocrine systems (glands) will be functionally characterized in detail. Using loss-of-function mutants and transformed plants with respect to CP-specific the role of CP-specific in electrical signalling, excitation contraction coupling, and excretion will be unravelled. The evolution of electrical activity and carnivory of plants is worth being examined not only for its importance in general, but also as a model for understanding the evolution of the human nervous and endocrine system.

Keywords: carnivory,genomes,systems biology,excitability,endocrinology,sensory biology
The evolution of mechanisms that control behaviour (EVOMECH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Evolutionary, population and environmental biology
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2015-05-31
Duration (months): 60.0
Total project cost (EUR): 1749277.0
EU funding (EUR): 1749277.0
Participants: 1
Project status: CLOSED

The approach to animal behaviour adopted by behavioural ecology is based on the investigation of the adaptive function of behaviour. A common assumption is that the action of natural selection on behaviour can be predicted without reference to processes inside the organism. I believe that it is time to combine an analysis based on evolution with one based on mechanisms, where a mechanism might be psychological, physiological or a combination of both. Animals have mechanisms that need to perform well in changing and dangerous environments. In order to understand the evolution of mechanisms, we need a fundamental change in the sort of models that are analysed. Instead of building complex models of optimal behaviour in simple environments, we need to evolve simple mechanisms that perform well in complex environments. This approach can provide a novel and unified perspective on a range of issues involving decisions by animals, including humans. The main objective of the project is to provide a comprehensive view of behaviour that can account for both adaptive and non-adaptive actions. This involves developing a novel theoretical framework based on an understanding of the underlying information-processing rules, combined with an evolutionary perspective that explains how any such rule came into existence in the first place. The theme of coping with uncertain and dangerous environments is used to investigate various features of behaviour such as rationality and self-control. These topics lead to the broader issues of the organisation of thought and emotions. The project also explores the consequences of the evolved behaviour and the implications for conservation and animal welfare.

Keywords: discounting,transitivity
Elucidation of MicroRNAs as Regulators of Metabolism and Targets for Therapeutic Intervention (METABOLOMIRS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Switzerland
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-07-01
End date: 2015-06-30
Duration (months): 60.0
Total project cost (EUR): 2021235.0
EU funding (EUR): 2021235.0
Participants: 1
Project status: CLOSED

Small RNA-mediated regulation of gene expression is a recent addition to fundamental gene regulatory mechanisms that directly or indirectly affect possibly every gene of a eukaryotic genome. The predominant sources of small RNA in somatic tissues are microRNA genes that encode short dsRNA hairpins of evolutionary conserved sequence. Disorders of metabolism, such as obesity and type 2 diabetes are poorly understood at a molecular level. In this application we propose to explore if miRNA regulatory networks play a role in these diseases. We will employ state of the art methods for identification of small RNAs and their regulated targets and use biochemical, cell and animal model systems to study the detailed molecular mechanisms of metabolic gene regulation by miRNAs. In addition, we will investigate the underlying principles of how RNAs are taken up by cells and develop methods that will improve delivery of miRNA mimetics or inhibitors through cell-specific uptake. The specific aims of this study are: Aim 1: To define the small regulatory miRNA content of liver, muscle and adipose tissue that are associated with abnormal glucose and lipid homeostasis and to dissect the underlying molecular pathways that govern their expression. Aim 2: To characterize the functions of miRNAs in insulin resistance, glucose uptake and production, fatty acid oxidation and lipogenesis. Aim 3: To identify factors and dissect the pathways that regulate RNA uptake by cells and to develop novel pharmacological treatment strategies to manipulate miRNA-expression. Together, this proposal will shed light on the function that miRNA regulatory networks play in metabolism and in the pathophysiology of obesity/type 2 diabetes. In addition, these studies will contribute to the development of new RNA delivery technologies that are urgently needed as experimental tools as well as for novel therapeutic strategies.

Keywords: diabetes,obesity,micrornas,therapeutics,rna transport