Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Catalysis toward platinum substrates for drug delivery (DELCAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-20
End date: 2023-09-19
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Flavins can act as efficient photocatalysts for the conversion of Pt(IV) complexes into Pt(II) anticancer drugs such as cisplatin and carboplatin (Chem. Sci., 2017, 8, 4619; Angew. Chem. Int. Ed., 2018, 57, 3143; ACS Catal., 2020, 10, 187). These unconventional catalytic reactions are bioorthogonal. Thus, they occur with high selectivity in biological environments, with minimal off target reactions. Nevertheless, advancing the application of this original chemistry in chemotherapy requires an optimal co-localization of the flavin catalyst and Pt(IV) substrate in cells or tissues in order to control the release of active Pt(II) drugs upon photocatalytic activation. To this end, DELCAT proposes the covalent entrapment of Pt(IV) anticancer complexes and flavins, such as riboflavin and its functionalized derivatives, into biocompatible agarose (AG) and polyglycerol (PG) hydrogels. The functionalization versatility of these polymers is ideal for the development of drug delivery platforms that could display various loading capacities, pharmacokinetics and drug release profiles. Hence, the project will engineer AG and PG hydrogels of different structure for loading flavins and Pt(IV) prodrugs, and then assess the drug delivery capacity of these materials in skin tissues. Ultimately, the project will provide innovative photocatalytic polymeric biomaterials for the efficient administration of platinum-based anticancer drugs.

Keywords: transition metals,medicinal chemistry,biomaterials
Bacterial Amyloid Secretion: Structural Biology and Biotechnology. (BAS-SBBT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2020-11-30
Duration (months): 66.0
Total project cost (EUR): 1989488.75
EU funding (EUR): 1989488.75
Participants: 1
Project status: CLOSED

Curli are functional amyloid fibers that constitute the major protein component of the extracellular matrix in pellicle biofilms formed by Bacteroidetes and Proteobacteria. Unlike the protein misfolding and aggregation events seen in pathological amyloid diseases such as Alzheimer’s and Parkinson’s disease, curli are the product of a dedicated protein secretion machinery. Curli formation requires a specialised and mechanistically unique transporter in the bacterial outer membrane, as well as two soluble accessory proteins thought to facilitate the safe guidance of the curli subunits across the periplasm and to coordinate their self-assembly at cell surface. In this interdisciplinary research program we will study the structural and molecular biology of E. coli curli biosynthesis and address the fundamental questions concerning the molecular processes that allow the spatially and temporally controlled transport and deposition of these pro-amyloidogenic polypeptides. We will structurally unravel the secretion machinery, trap and analyse critical secretion intermediates and through in vitro reconstitution, assemble a minimal, self-sufficient peptide transport and fiber assembly system. The new insights gained will set the stage for targeted interventions in curli -mediated biofilm formation and this research project will develop a new framework to harness the unique properties found in curli structure and biosynthesis for biotechnological applications as in patterned functionalized nanowires and directed, selective peptide carriers.

Keywords: protein transport,self assembly,functional amyloid,bacterial secretion system,biofilm
Speciation and hybridization: a sex chromosome perspective (Hybrid Conflicts)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

How do new species arise and how do closely related species maintain their integrity despite hybridization? Notwithstanding the central position of these questions in the fields of evolutionary and conservation biology, few biologists have provided answers. Here, I will address these questions using a multidisciplinary approach combining genomics, lab experiments and field work. The key objectives of this project is to determine the factors that lead to genomic divergence between closely related and hybridizing species and characterise DNA sequence changes that are associated with pre- and postzygotic barriers to species exchange with emphasis on the role of the X chromosome. Training-through-research includes a secondment to another lab to improve skills in animal breeding and experiments. This action will also generate new resources to the scientific community (a damselfly genomics toolkit), and efficiently disseminate knowledge to the public. Due to its multidisciplinary approach and many opportunities for collaboration, executing this research program will provide new avenues of research for my future career as independent researcher within the EU. The excellent supervision and state of art infrastructure at the host lab will ensure the successful execution of this project.

Keywords: speciat,hybridization,sex chromosome,damselfly
Enhancing the innovation management capacities of SMEs in East Poland (KAM2EastPoland)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Poland,Poland,Poland,Poland
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 80500.0
EU funding (EUR): 80500.0
Participants: 6
Project status: CLOSED

Main objective of the project is increasing efficiency and effectiveness of R&D and innovation investments which will contribute to smart growth in EU countries. The project also focuses on strengthening of collaboration between different actors important in innovation chain. Innovation development among SMEs (99% of enterprises in EU) is crucial to smart and sustainable growth. Specific objectives will be implemented by Enterprise Europe Network East Poland Consortium. Project duration is forseen for 24 months and will end by the end of December 2016. Within the Consortium – 10 WP 1 “Key account management” services packages and 36 WP2 “Enhancing the innovation management capacity of SMEs” service packages are foreseen. Number of service packages planned is based on economic indicators and Enterprise Europe Network experts’ experience. The Enterprise Europe Network is the biggest network in Europe that provides high quality and specialised support for SMEs. The Network was established in 2008 and will still be operating in years 2015-2020, thus has great potential to provide additional support services for companies with possibilities for international growth and innovation implementation. Five Enterprise Europe Network partners in lubelskie, podlaskie and warminsko-mazurskie voivodeship are ready to participate in the action with the following input: Lublin Development Foundation - P1 - 2 service packages, Lublin University of Technology - P2 - 12 service packages Podlaska Regional Development Foundation P3 - 10 service packages University of Warmia and Mazury in Olsztyn - P4 - 12 service packages Warmia and Mazury Regional Development Agency - P5 - 10 service packages The consortium management structure will be based on Enterprise Europe Network East Poland. WP1 and WP2 services will be provided in each region covered by the Consortium.

Keywords: innovation management,capacity building,innovation expert,sme instrument,horizon 2020,key account management,enhancing innovation management
API-Enabled Invoice Protection in Europe (APIIP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 2840337.5
EU funding (EUR): 1988236.25
Participants: 1
Project status: CLOSED

Every year across Europe, hundreds of thousands of companies are driven into insolvency because of late or non-payment of invoices. Trade credit insurance exists to mitigate this issue. However, the SMEs who could benefit the most do not currently have access because it is traditionally distributed by brokers, for whom the commissions generated by an SME are too low to justify the cost of sale. Our vision comprises three pillars: • commercial innovation - to make our Invoice Protection product available to SMEs by offering it at the point of need, as orders are accepted or invoices raised on the cloud accounting platforms or B2B marketplaces that SMEs use daily; • analytical innovation - cutting-edge data science for superior credit analytics; • technological innovation - real-time and automated pricing, underwriting and policy administration engines. With current penetration only 0.25% today, we are creating the credit insurance market for SMEs. Our three founders (ex-COO of a global insurer; ex-CEO and ex-CTO of the innovation unit at the world’s leading credit insurance co.) have the deep industry expertise and commercial insight required to make this project a success. To date we have signed a deal with SCOR (the world’s 4th largest reinsurer) giving us risk capacity; launched our technology in the UK (demonstrating TRL6; our first policy was sold via centrifuge.io, a trade finance fintech); begun onboarding another three partners in the UK; and built up a strong distribution pipeline with prospective European partners. Work in this project will allow us to protect German and French SMEs for both their domestic trade and exports to the UK, Spain, Italy and the USA by integrating with our distribution partners, building credit analytics models and establishing insurance infrastructure. The project is a platform for further international and product expansion. SME instrument funding will enable us to realise €55M revenue within five years.

Keywords: insuretech,invoice protection,trade credit insurance,credit modelling,new business models
GasFermTEC: Gas Fermentation Technologies ERA Chair (GasFermTEC)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Estonia
Call: ERA Chairs (H2020-WIDESPREAD-03-2017-ERAChairs, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 2496875.0
EU funding (EUR): 2496875.0
Participants: 1
Project status: SIGNED

The GasFermTEC project aims to recruit an experienced researcher and research manager, to act as an ERA Chair, and lead a team of researchers at the Estonian Centre for Biosustainability (ECB) to support and coordinate the setup of (i) a research direction specializing in gas fermentation technologies, ii) structural changes at ECB to implement a new model of partnership between academia and industry, iii) a training centre on biosustainability. The ERA Chair will be an expert in the field of gas fermentation – intimately linked to the other research groups (e.g. synthetic biology, chemical engineering, bioprocessing) and other initiatives at the ECB (the CelESTial Teaming project and the SynBioTEC). It will lead to solutions to capture carbon through bio-based production of fuels and high-value chemicals from globally available feedstocks, including waste gases and syngas produced via gasification of municipal waste and biomass; an initiative that will positively contribute to the Environmental Challenges and to the Smart Specialisation Strategy of Estonia. Structural measures regarding the research strategy of the ECB and its positioning within an industry context will be established, including planning for i) an innovative cooperation structure, the ECB-Industry-Association and ii) an ECB Pilot Plant. The Association will coordinate activities of the Pilot Plant project for the industrial optimization of bioprocessing technologies. The pilot plant, combined with a training and competence centre, will provide the local bioprocessing industry with research-based innovative technology solutions, and serve as a broad public platform for a debate on biosustainability.With the GasFermTEC project, the ECB expects to increase its research capacity to become more visible and competitive, and more capable of attracting external funding through participation in international research initiatives – leading to its vision of becoming a leading European centre of excellence.

Keywords: sustainable bioprocessing,synthetic biology,cell factories,gas fermentation,syngas
Plants seeking iron: unraveling the molecular mechanisms involved in iron-mobilizing coumarins distribution and trafficking (PlantSeeFe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

Iron (Fe) is an essential micronutrient for the productivity of crops and the quality of their derived products. Fe deficiency-induced anemia affects billions of people worldwide. This could be mitigated by improving the capacity of plants to absorb and store Fe, which will help to provide adequate dietary Fe to the growing global population. Decrypting the molecular mechanisms plants have evolved to acquire Fe from the soil is essential for reaching this objective. Recently, the secretion in the soil of root-borne coumarins has emerged as a key factor affecting Fe uptake in non-grass species. However, the mechanisms that modulate coumarin storage and trafficking within plant roots are not well understood. The candidate has coupled microarray data mining with in vivo coumarin transport assays and identified four novel Arabidopsis coumarin transporters, namely NPF7.2, NPF2.3, NPF2.4 and NPF2.5. The objective of this project is to determine the precise function of each of these four transporters in coumarin trafficking and plant Fe nutrition. In work package 1 (WP1), the coumarin transport activities of NPF candidates will be examined in detail using yeast cells and Xenopus oocytes. Moreover, we will generate single (insertion/transposon lines) and multiple (CRISPR/Cas9) mutants in order to precisely define the role of each NPF in plant roots. Next, in vivo imaging of coumarin and NFP candidate protein localization will be conducted to ascertain the role of each candidate in the spatiotemporal distribution of coumarins within the roots (WP2). Finally, the posttranslational regulation of the NPF candidates will be investigated using proteomic approaches (WP3). The proposed project is both feasible and appropriate for a Marie Skłodowska-Curie Individual Fellowship, since the expected outcomes are innovative and will generate knowledge for both fundamental and industrial research, while the candidate will improve his skills and knowledge in a specialized research area.

Keywords: iron,plant nutrition,secondary metabolite,coumarins,transport,npf transporter,agricultural science
Autistic Perception and the Predictive Role of Visual Experience (APPROVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Localizing stimuli in our environment is crucial for virtually all motor, perceptual and cognitive tasks. The brain is constantly confronted with sensory information that must be processed efficiently to facilitate appropriate reactions. One way of improving processing efficiency is to predict incoming sensory information based on previous experience. However, the way in which prior experience ("priors" within the Bayesian framework) and current sensory inputs are combined varies between individuals. This project is based on state-of-the-art eye-tracking experiments driven by recent theoretical developments in Autism Spectrum Disorder research. While abnormalities in saccade accuracy in ASD have often been reported, here we investigate the novel hypothesis that impairments in saccade efference-copy processing are responsible for the build-up of weak priors. The project focuses on the dynamic processes by which the brain samples visual scenes to update its model. Eye-movement and pupillometry indices will be used to track differences in visual behavior between ASD and matched controls. The project is intrinsically multidisciplinary, combining educational psychology, neuropsychology, psychophysics, eye-movement and pupillometyry measurement, and virtual reality. This proposal includes both the transfer of knowledge from the host institution and the training of the candidate in new advanced techniques. The results have the potential capacity to lead to a deeper understanding of the perceptual symptoms of ASD, and may also provide a biomarker of ASD. Finally, the project will provide a new theoretical framework within which to conceptualize the role of priors and predictions in visual behavior in normal and pathological eye-movement development which will lay the groundwork for new insights into the link between potential early visual behavior vulnerability in childhood and the subsequent onset of socio-communicative difficulties and behavioral stereotypes in adulthood.
Support to the Europe PMC initiative (2021-2026) (ERC-EuropePMC-2020)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: Support to the Europe PMC initiative (H2020-IBA-ERC-EPMC-2020, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 7252184.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: SIGNED

This proposed action will ensure the continued support to the European Research Council (ERC) in the implementation of its Open Access strategy for projects funded in the Life Sciences domain. The ERC was first able to offer the benefits of Europe PubMed Central (Europe PMC http://europepmc.org) to its funded researchers in 2013 through “Support towards the Europe PMC initiative – Contribution for 2013” (ERC-EuropePMC-SUP-2013). Since then two subsequent rounds of funding have ensured the continuation of this provision (“Support towards the Europe PMC initiative – Contribution for 2014-2016” (ERC-EuropePMC-1-2014) and “Support to the Europe PMC initiative – Co-funding grant for the 2016-2021 period” (ERC-EuropePMC-2015)). The project for which funding is sought, on a co-funding basis, concerns the awarding and monitoring of a grant to EMBL-EBI to ensure the continued maintenance and development of Europe PMC. The application from EMBL-EBI to Wellcome Trust outlines their strategy and objectives for Europe PMC including further development of its services in the areas of data linkage and text mining to enrich content within the repository and to support the monitoring of funder open access policies. Support is requested for the period 1st April 2021 – 31st March 2026 (60 months).

Keywords: open access,infrastructure,repository
Molecular Tools for Nucleic Acid Manipulation for Biological Intervention (MMBio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Italy,Italy,Switzerland,Belgium,Finland,Sweden,Switzerland,Sweden,Sweden,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-08-31
Duration (months): 56.0
Total project cost (EUR): 3971347.92
EU funding (EUR): 3971347.92
Participants: 19
Project status: CLOSED

MMbio will bridge the classically separate disciplines of Chemistry and Biology by assembling leading experts from academia and non-academic partners (industry, technology transfer & science communication) to bring about systems designed to interfere therapeutically with gene expression in living cells. Expertise in nucleic acid synthesis, its molecular recognition and chemical reactivity is combined with drug delivery, cellular biology and experimental medicine. This project represents a concerted effort to make use of a basic and quantitative understanding of chemical interactions to develop and deliver oligonucleotide molecules of utility for therapy. Our chemical biology approach to this field is ambitious in its breadth and represents a unqiues opportunity to educate young scientists across sectorial and disciplinary barriers. Training will naturally encompass a wide range of skills, requiring a joint effort of chemists and biologists to introduce young researchers in a structured way to and array of research methodologies that no single research grouping could provide. The incorporation of early-stage and later stag ebiotechnology enterprises ensures that commercialisation of methodologies as well as the drug development process is covered in this ITN. We hope that MMBio will train scientists able to understand both the biological problem and the chemistry that holds the possible solution and develop original experimental approaches to stimulate European academic and commercial success in this area.

Keywords: chemical biology,bioorganic chemistry,nucleic acid,drug,transfection,therapy,antisense