Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SENSING CELL-CELL INTERACTION HETEROGENEITY IN 3D TUMOR MODELS: TOWARDS PRECISION MEDICINE (INTERCELLMED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-12-31
Duration (months): 71.0
Total project cost (EUR): 1050000.0
EU funding (EUR): 1050000.0
Participants: 1
Project status: SIGNED

This project aims to investigate the role of potassium (K+), protons (H+) and oxygen (O2) gradients in the extracellular space of tumour cells grown in 3D cultures by using a combination of imaging, cell biology and in silico analyses. By embedding ratiometric fluorescent particle-based sensors within 3D scaffolds, the changes in target analyte concentrations can be monitored and used to study the interactions between tumour cells and stromal cells in 3D tumoroids/scaffolds and to monitor response of the cells to drug treatments. I first demonstrated successful fabrication of barcoded capsules for multiplex sensing of H+, K+, and Na+ ions. Next, I demonstrated the use of pH-sensing capsules as valid real time optical reporter tools to sense and monitor intracellular acidification in living cells. Thus, I can fabricate capsule sensors for investigating the role of key analytes that are involved in regulation of crucial physiological mechanisms. In addition, I successfully integrated pH-sensing capsules within 3D nanofibrous matrices and demonstrated their operation under pH switches. INTERCELLMED will engineer 3D scaffolds that do not only sense extracellular pH but are also able to sense K+ and O2 changes. To this aim, a novel set of anisotropic analyte-sensitive ratiometric capsules will be developed and applied for generating robust and flexible capsules-embedded sensing scaffolds. To validate the functions of the 3D sensing platform, cocoltures of tumour cells and stromal cells will be grown and their interaction and response to drug treatments will be studied by mapping the K+/H+/O2 gradients in and around the cell aggregates. Finally, the 3D sensing platform will be adapted for growing tumour tissue-derived cells that will be tested ex-vivo with anticancer dugs. Specific mathematical models of cellular interactions will be developed to represent the biological processes occurring within the 3D sensing platform.

Keywords: imaging,three dimensional scaffolds,optical ratiometric biosensors,cancer cells,stromal cells,cell cell interactions
Screening, characterisation and engineering of carbohydrate harvesting machineries of microbial ecosystems (CaTSYS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Mammals rely entirely on their symbiotic microorganisms to digest complex glycans, issued from dietary fibers, yeasts, and the host itself. To that purpose, gut bacteria have evolved sophisticated machineries to face the structural diversity and complexity of carbohydrates, consisting of gene clusters coding for carbohydrate-hydrolysing, -binding and -transporting proteins. Since the last decade, functional metagenomics has proved to be a highly powerful technique to boost the discovery of new protein families involved in these multi-proteic systems from the vast world of uncultured bacteria, which represents the majority of gut microorganisms. By using a multidisciplinary approach, integrating genomic, metagenomic, functional and structural data, CaTSYS will decipher the structure-function relationships of novel key carbohydrate active enzymes and transporters recently discovered by functional exploration of the human and bovine gut microbiomes. Their role in carbohydrate harvesting pathways will be investigated and optimised by combinatorial engineering, thanks to the development of an original high-throughput screening approach, to render heterologous hosts capable of internalising and breaking down a large diversity of complex carbohydrates. Overall, CaTSYS will provide a promising framework to overcome future challenges in biotechnology, for the conversion of carbohydrate polymers into biosourced chemicals and/or high-added value compounds.

Keywords: cazymes,transporters,metagenomics,protein engineering
Sustainable Fibre-Reinforced Polymer Concrete (FRP-RC) Structures (SusFRPRC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Lithuania
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-06
End date: 2019-04-05
Duration (months): 24.0
Total project cost (EUR): 130779.6
EU funding (EUR): 130779.6
Participants: 1
Project status: CLOSED

The corrosion problem of steel reinforcement severely limits the life-cycle sustainability of conventional reinforced concrete structures. This proposal focuses on the use of corrosion-free fibre-reinforced polymer (FRP) reinforcing bars in lieu of steel reinforcing bars in concrete structures. Due to the currently incomplete understanding of serviceability aspects of FRP reinforced concrete (FRP-RC) structures, the existing design guidelines are not comprehensive, and this restricts the applications of FRP-RC in real-life. The proposed project will investigate the fundamental issues of serviceability, fracture mechanics and time-dependent effects of FRP-RC to enable its practical usage. The objectives encompass experimental investigation of deformation characteristics of FRP-RC specimens, derivation of constitutive models and establishment of deformation capacity of FRP-RC members, formulation of design guidelines in serviceability and development of design aids for use by practising engineers. A number of first-time-in-the-world techniques initiated by the applicant researcher, Dr. Pui-Lam NG and the host supervisor, Prof. Gintaris KAKLAUSKAS of Vilnius Gediminas Technical University (VGTU) will be employed in the project. The expertise areas of the researcher and the host are highly complementary and there will be substantial two-way transfer of knowledge. The researcher and the host propose to undertake the project with partner organisations University of Minho led by Prof. Joaquim A.O. BARROS, and University of Cambridge led by Prof. Chris BURGOYNE, in 24 months duration. Measures to disseminate the research findings to the academic and engineering communities and communicate the results to the general public have been formulated. A detailed work plan of research activities, deployment of manpower and resources, contingency plan for risk mitigation, and availability of research infrastructure have been duly addressed to enable effective delivery of the project.

Keywords: constitutive model,fibre reinforced polymer,serviceability,structural design,sustainable concrete structure
The Disrupted Society: mapping the societal effects of blockchain technology diffusion (BLOCKCHAINSOCIETY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1499631.0
EU funding (EUR): 1499631.0
Participants: 1
Project status: SIGNED

Recent advances in cryptography yielded the blockchain technology, which enables a radically new and decentralized method to maintain authoritative records, without the need of trusted intermediaries. Bitcoin, a cryptocurrency blockchain application has already demonstrated that it is possible to operate a purely cryptography-based, global, distributed, decentralized, anonymous financial network, independent from central and commercial banks, regulators and the state. The same technology is now being applied to other social domains (e.g. public registries of ownership and deeds, voting systems, the internet domain name registry). But research on the societal impact of blockchain innovation is scant, and we cannot properly assess its risks and promises. In addition, crucial knowledge is missing on how blockchain technologies can and should be regulated by law. The BlockchainSociety project focuses on three research questions. (1) What internal factors contribute to the success of a blockchain application? (2) How does society adopt blockchain? (3) How to regulate blockchain? It breaks new ground as it (1) maps the most important blockchain projects, their governance, and assesses their disruptive potential; (2) documents and analyses the social diffusion of the technology, and builds scenarios about the potential impact of blockchain diffusion; and (3) it creates an inventory of emerging policy responses, compares and assesses policy tools in terms of efficiency and impact. The project will (1) build the conceptual and methodological bridges between information law, the study of the self-governance of technological systems via Science and Technology Studies, and the study of collective control efforts of complex socio-technological assemblages via Internet Governance studies; (2) address the most pressing blockchain-specific regulatory challenges via the analysis of emerging policies, and the development of new proposals.

Keywords: blockchain,internet governance,information law,cyberlaw
Delivering on the Promise of Measuring Dark Energy from Cosmic Lensing (COSMIC LENS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-05-01
End date: 2021-04-30
Duration (months): 60.0
Total project cost (EUR): 1997219.0
EU funding (EUR): 1997219.0
Participants: 1
Project status: CLOSED

The apparent gravitational distortion of distant galaxies, ‘cosmic lensing’, allows us to map dark matter and hence unveil the nature of the mysterious dark energy. I will develop novel approaches to cosmic lensing and use these to place constraints on dark energy using the Dark Energy Survey (DES). Themes 1 and 2 address key systematic effects crucial for the extraction of cosmology in theme 3. Theme 1: The lensing community has spent two decades trying to find the perfect galaxy shape measurement method. We will take a unique approach by translating a technique common in particle physics and the CMB to lensing: we will simulate images matched to observed galaxy positions and shapes, and vary lensing to accurately calibrate shapes. We will make the code public and use it to produce the final public DES shear catalogues. Theme 2: We will exploit my innovative and successful program of coordinated international challenges from shear measurement and apply it to mitigating galaxy intrinsic alignments (IA). I have shown that knowledge of IAs is essential for leveraging the potential of cosmic lensing for cosmology and described a mitigation method, but this needs to be tested on simulations. I will coordinate international IA simulation efforts and identify the optimum method for removing intrinsic alignments and apply it to the DES data. Theme 3: We have developed a skeleton software framework for cosmology, CosmoSIS. We will write modules for cosmology from imaging data incorporating the main systematic effects, and use CosmoSIS to produce the final constraints on cosmology from DES lensing. We will incorporate constraints on sterile neutrinos from particle physics for the first time. If the current tensions between cosmic lensing the CMB are confirmed by this work we will have discovered the need for new physics. Furthermore, the work in this proposal will place us in prime position to exploit the main cosmology surveys of the next decade (LSST, Euclid, WFIRST).

Keywords: gravitational lensing
Operational sustainable forestry with satellite-based remote sensing (MySustainableForest)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Spain,Lithuania,Finland,Croatia,France,Czechia,United Kingdom,Portugal
Call: Downstream applications (H2020-EO-2017, 2017)
Start date: 2017-11-01
End date: 2020-10-31
Duration (months): 36.0
Total project cost (EUR): 2299713.75
EU funding (EUR): 1875049.63
Participants: 11
Project status: CLOSED

Forests, cornerstone of the EU economy (42% of EU land) and source of multiple social and environmental benefits, need to be managed according to the sustainability principles as stated in EU Forest Strategy. However managers lack accurate / up-to-date data to support it. Traditional forest inventories characterize forests from the ecologic and dasometric perspective; but they are expensive and typically planned on a 5-10years basis. This periodicity is often much lower than required for planning forests´ commercial or recreational activities on the basis of these data. Forest change rates demand tools able to monitor, on annual basis, the forest extension, the attributes of available timber, or the different ecosystem services emerged. MySustainableForest aims to develop a pre-commercial service and platform for forest stakeholders, compliant with open and standard interfaces, to integrate Earth Observation into the forest stakeholders’ decision making processes and operations. It will be implemented on the basis of GMV prototyped service, eoForest and will leverage on partners’ expertise on LiDAR and forest modelling. It engages relevant European public and private forest stakeholders: RAIZ (R&D branch of The Navigator Company), Croatian Forest Research Institute, Mendel University in Brno, Forest Owners Association of Navarra and Lithuania, Centre Nationale de la Propriété Forestière, European Forest Institute, and 2 innovative SMEs (MADERA+ and Föra). Its added value will be demonstrated in 6 different bioclimatic zones from Portugal, Spain, France, Croatia, Czech Rep. and Lithuania, and across a variety of management protocols and forest usages. The economic viability of the service will be assessed and the associated business model validated. As a larger implication of MySustainableForest, it is expected that End-Users optimize their operations up to 10%, participating SMEs´ headcounts increase up to 20% and GMV market share in the sector is incremented up to 10%.

Keywords: earth observation,forestry management decision support service
A cost-effective, out-of-the-box photon counting platform for multi-photon in vivo microscopy applications (PySightBox)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-10-01
End date: 2022-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Multi-photon microscopy is the gold-standard brain imaging approach to study the brain and other organs in action and is used across hundreds of laboratories worldwide. The current attempts to imaging increasingly large tissue volumes pushed multi-photon microscopy into the photon-deprived regime (i.e. the dim conditions that result from moving faster allowing collection of less photons per pixel/voxel). Under these condition, the relative few photons detected can be lost in the electronics noise of the system. Photon-counting techniques overcome this hurdle yet its implementation requires either custom electronics (and electronics expertise) or the use of relative expensive commercial solutions that are not tailored for this type of imaging thus providing only a partial solution. Therefore there is an unmet need in the market today for an easy to implement photon counting solution that seamlessly integrates into existing imaging setups and provides all the required software to perform intravital multi-dimensional imaging. This project aims to commercialize PySight, an add-on hardware and software solution tailored exactly to fill this market gap. Moreover, the product I propose to develop here targets both the academic and medical sectors as multi-photon diagnostic are becoming more common nowadays. Beyond achieving the unmet needs, our prototype improves many aspects of imaging (such a neuronal population imaging in single and rapid volumetric imaging). Its spatio-temporal resolution outperforms top-tier imaging setups while retaining over 200 times lower data rates. Importantly, PySight requires no electronics expertise and its software is open-source.

Keywords: neuroscience,multi photon imaging,photon counting,volumetric imaging
INSECTS FOR A SUSTAINABLE AQUACULTURE 2 (IFASA 2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: CLOSED

The consumption of fish protein is essential to the livelihood and well-being of billions of people worldwide, and aquaculture is a sustainable way to produce healthy fish while preserving wild fish stocks. With a 10% yearly growth over the past decade, aquaculture is one of the fastest growing sector in the food industry. Yet, sector’s expansion and sustainability are challenged by current fish feed limitations. Indeed, fishmeal and soybean meal are the two main ingredients in fish feed formulations and both hold challenges in terms of sustainability and nutritional value: Fishmeal absorbs up to a third of wild caught fish, contributing to the depletion of fish stocks and its availability is limited due to fishing quotas with a direct impact on price (price rise from 500 euros per ton in 2004 to 1,500 euros per ton today ); Soybean meal contains anti-nutritional factors for most farmed fish and its use for aquaculture increases Europe’s protein deficit and dependency on raw material imports. Today, 80% of protein-rich crops used in Europe for animal feed, i.e. mostly soybean meal, are imported . Fish feed manufacturers and fish farmers are seeking innovative ways to increase the nutritional value of their products while reducing the environmental impact of their supply chain. Insect protein stands out as one of the best solution to address this need and drive the development of sustainable aquaculture. Insect protein has demonstrated excellent nutritional performance with less pollutants than fishmeal (heavy metals, pesticides residues, PCBs, dioxins), restoring a natural diet for farmed fish that eat insects in the wild (e.g. salmon, trout, seabass). InnovaFeed’s insect protein is an alternative source of quality protein that will address the fish feed challenge and support the aquaculture sector’s growth. InnovaFeed has optimized the zootechnical model of Hermetia illucens (European endemic fly species) to achieve maximum productivity and consist

Keywords: industrial scale up,novel protein,insect mass rearing,fish feed,feed ingredients,animal nutrition,entomology,waste and biomass valorization,circular economy,food security
An efficient floating structure and installation of offshore large wind turbines. (ARCHIME3)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Spain
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 3488633.25
EU funding (EUR): 2442043.28
Participants: 2
Project status: SUSPENDED

WHO WE ARE? BERIDI is a spin-out company of Berenguer Ingenieros, founded in 2018, as the division of the group specialized in the offshore wind energy sector. Our group is a leading seashore engineering firm, which has worked in more than 1,200 projects in Spain and LATAM, including + 40 multimillion projects. THE PROBLEM: EU must install 230-450 GW new offshore capacity before 2050 to fulfil the Green Deal Goals. but current space available in shallow imposes a limit of 112 GW. Only new floating platforms can help EU fulfil its objectives, but the installation of floating turbines is still technically challenging, very expensive and highly time-consuming, especially for the largest turbines (>15 MW). THE SOLUTION: We have patented a new floating technology that enables the safest and most efficient (time, costs and performance) installation of turbines in deep waters. ARCHIME3 is, to the best of our knowledge, the only technology today that will enable the installation of the largest turbines (15-20 MW) in deep waters in an efficient and safe manner. MARKET OPPORTUNITY: The market opportunity at a global level for now to 2030, reaches more than €20 Billion. Just by achieving a market penetration of 10%, our market opportunity can reach €2 Billion from now until 2030. Our financial projections for 2026, when we expect to have installed our first wind farm (400 MW), would mean €44M of cumulated turnover, €20M of cumulated EBIDTA and close to €240M of company value, meaning a x13 ROI for the investment (2.4 M Grant + 4.8 M equity) requested to the EIC for this project.

Keywords: offshore wind energy