Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unifying ecophysiological predictions of ectotherms to global warming (e_WARM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Chile,Australia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 221390.88
EU funding (EUR): 221390.88
Participants: 3
Project status: SIGNED

Ongoing climate change represents a major threat to biodiversity, and scientists now face pressing concerns to forecast how ecological communities will respond to global warming in the medium- to long-term. However, the current framework to study heat tolerance rely on critical thermal limits (CTmax), which comprises a coarse metric that has been shown to be unrealistic. Not only results from CTmax are ludicrous, they do not allow for temporal forecast. Unfortunately, this is what overwhelming majority of research groups are now measuring, at an enormous waste of time and human effort. The e_WARM project proposes the ambitious umbrella objective of stablishing a unified predictive framework for the study of heat tolerance in terrestrial and aquatic ectothermic animals. For this purpose, the candidate will develop a novel comprehensive analytical toolbox to anticipate heat mortality with a unprecedented accuracy and reliability. This approach translates high-resolution temperature records from the field into realistic mortality rates of species. Importantly, the analytical routines proposed can be expanded to include the interplay of warming with other factors, such as heat waves, phenotypic plasticity or hypoxic stress. As a proof of concept, the candidate will study Drosophila species as model organisms from terrestrial, and Daphnia species (invertebrate) and Galaxias maculatus (fish) as model organisms from aquatic ecosystems, The subject of the e_WARM project is both timely and important, as more reliable predictions of the impact of global warming on populations’ resilience are urgently needed. Repercussions of this research will be immediately transmitted to the society, and they will have a big scientific, political, economic and health impact.

Keywords: climate vulnerability,heat tolerance,oxygen limitation,thermal biology,global warming,biogeography,critical thermal limits,drosophila,daphnia,population growth rate,
CCoat: Restoring cartilage lubrication to enable pain-free joint articulation for osteoarthritis patients (CCoat)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

As we age, our cartilage tissue wears off, especially in major joints such as the knees, leading to pain, limitations in mobility, and a condition called Osteoarthritis (OA). OA is a painful chronic joint condition resulting in progressive damage and affecting over 600M people worldwide. Today, there are no non-surgical treatments that effectively prevent, reverse, or even delay OA progression. Prior to requiring knee replacement surgery, the current standard of care focuses on pain management, using anti-inflammatory drugs, and, more often, intra-articular (IA) knee joint injections such as hyaluronic acid (HA), which aim to reduce pain and assist in restoring natural lubrication. However, under high loads in the knees, viscous-supplement-based products such as HA do not work, have side effects, and high costs. This lack of good solutions results in patient suffering and high healthcare and economic costs. This is where we come in. Liposphere is an innovative female-led start-up spun out from the Weizmann Institute in Israel, where, after 20+ years of R&D, the Hydration Lubrication Mechanism (HLM) was discovered: A unique water-based joint articulation compound. Based on HLM, we developed CCoat. CCoat, based on our patented technology, is a new IA injectable biocompatible joint articulation compound that coats the joints’ cartilage surface and protects it from further damage and degradation by restoring its natural mechanical lubrication. It is water-based, involving no drugs. Our trials have proven it has high efficacy in reducing pain, and in slowing down OA progression by protecting the cartilage for at least six months per use. It will reduce pain, delay knee replacement surgeries, improve lives, and save healthcare costs. In this project, with the EIC support, we will finalize CCoat for commercialization, complete clinical trials in Israel and Germany, and apply for a CE medical certifications. We will then launch CCoat for OA treatment, starting in Europe

Keywords: surface lubrication,wear reduction,hydration lubrication,materials science,liposomes,polymers,osteoarthritis,orthopaedics
Mechanisms of Skeletal Muscle Adaptation to Resistance Training in Spinal Muscular Atrophy (SMA-RT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2029-01-31
Duration (months): 36.0
Total project cost (EUR): 396991.08
EU funding (EUR): 396991.08
Participants: 2
Project status: SIGNED

Spinal Muscular Atrophy (SMA) is a debilitating neuromuscular disorder characterised by progressive motoneuron degeneration, which causes muscle atrophy and weakness. By combining pre-clinical studies and a clinical trial, this 36-month Global Fellowship aims to explore the beneficial role of exercise as a therapeutic strategy to support SMA treatment and improve clinical outcomes. During my outgoing phase at Harvard University, I will employ two transgenic SMA mouse models to investigate the skeletal muscle adaptations to overloading, achieved via synergistic ablation, a model historically used to study muscle hypertrophy and mimic human resistance training. In WP1, I will investigate the muscle morphological, functional, and transcriptomic responses to overloading in SMNΔ7 mutant mice, which, similarly to patients, present ubiquitous SMN deficiency and lifespan extension via pharmacological treatment. In WP2, I will perform the same overloading protocol and similar analyses on a mouse model presenting SMN knockout restricted to muscle satellite cells (Pax7:SMN-KO). While ubiquitous SMN deficiency triggers motoneuron degeneration, this model enables to focus on the role of satellite cells in SMA by deleting SMN selectively in these cells. During my incoming phase at the University of Padova, I will assess whether the molecular mechanisms underlying muscle adaptation identified in mice are translatable to humans, examining the response of SMA type III/IV patients, presenting the milder form of SMA, to a resistance training intervention (WP3). I will employ musculoskeletal imaging techniques, advanced EMG methods, and muscle biopsy and blood sample analysis to perform a comprehensive analysis, which is lacking to date. This project aims to propose exercise as a novel strategy to improve the quality of life in patients affected by SMA and other devastating neuromuscular disorders, also reducing the heavy socioeconomic burden associated with these diseases.

Keywords: spinal muscular atrophy exercise muscle overloading skeletal muscle,electromyography musculoskeletal imaging
INSIDER-CoV: Investigating Nasal and Systemic Immune Dynamics during SARS-CoV-2 Reinfections (INSIDER-CoV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: SIGNED

INSIDER-CoV: Investigating Nasal and Systemic Immune Dynamics during SARS-CoV-2 Reinfections The global challenge posed by COVID-19 necessitates a profound understanding of SARS-CoV-2, particularly concerning the phenomenon of reinfections. The INSIDER-CoV project seeks to address this critical gap by employing the Syrian golden hamster model, which has previously demonstrated its efficacy in primary infection studies. Central to this research is a meticulous exploration of the immune response within the nasal cavity, the primary gateway for the virus. By comparing this localized immune reaction to the broader systemic response, the project aims to shed light on the determinants of reinfection susceptibility and the intricacies of host-virus interactions during repeated exposures. The urgency and relevance of this investigation are paramount. As the dynamics of the pandemic continue to evolve, the potential for reinfections emerges as a pressing concern. Through rigorous investigation, INSIDER-CoV endeavors to refine the previous knowledge about SARS-CoV-2 reinfections, offering insights that could lead to the development of novel therapeutic interventions and preventive measures. While rooted in academic research, the implications of this study have the potential to influence pharmaceutical developments and inform public health directives on a global scale. Furthermore, the scope of INSIDER-CoV extends beyond the immediate crisis. By considering the broader context of potential respiratory pandemics in the future, the project ensures its relevance and applicability in the long term. In summary, INSIDER-CoV represents a pivotal step in the scientific community's ongoing efforts to combat current and future viral challenges. Through meticulous research and collaboration, this project aims to significantly contribute to the global understanding of viral infections and their broader implications.

Keywords: sars cov 2 immunology reinfection nasal cavity syrian hamster
Genetic engineering as an approach to enhance the lipid-binding properties of the Flowering locus T, the member of the Phosphatidylethanolamine-binding protein family (StickyFT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Slovenia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-11-06
End date: 2025-11-05
Duration (months): 24.0
Total project cost (EUR): 171399.36
EU funding (EUR): 171399.36
Participants: 1
Project status: SIGNED

EU Mission for Adaptation to Climate Change perceives the improved dryland agriculture as one of the ways to adapt and survive. Humans have the technology and processes to address the major agricultural issues today, such as pest infestation, droughts, the misuse of herbicides; however, the global warming requires a new set of tools and the willingness to adapt from all of us. The key developmental switch for the flower/fruit bearing plants is the change from vegetative to reproductive growth, and the timing is crucial. The climate changes have been already impacting the flowering, as several perennial and annual crops have flowered earlier by about 2 days per decade, during the last 50 years. The flowering locus T is a plant protein highly recognized as a part of the florigen complex, a mobile protein that is produced in the leaf companion cells and transported to the plant shoot apex to induce flowering. My previous work was focused on the FT preference to bind to phosphatidylglycerol (PG), over other lipid species, in the temperature-dependent manner, and the impact on the flowering time. The MSCA Project will address the relevance of the wider array of FT-PG interactions, by utilizing the genetic modifications to produce and characterize the FT mutant proteins with enhanced lipid-binding properties. The super sticky FT would be difficult to remove from the membrane, which could have a potential industrial application. A challenge would be to create the protein that could not bind to the membrane, which will shed a new light onto flowering regulation. The multidisciplinary approach, consisting of molecular biology, biochemistry, structural chemistry, and biophysics, will produce deliverables for the subsequent in planta project. The measured impact of different ambient temperatures will provide us with the knowledge of the fine-tuning and control over the protein-lipid interactions, which could have the long-standing effects in the agricultural applications.

Keywords: protein lipid interaction liposome system ambient temperature recombinant proteins genetic modification
Resource spirits: An interactionist approach to animism and extractivism in Southeast Asia (Re-S)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1981951.0
EU funding (EUR): 1981951.0
Participants: 1
Project status: SIGNED

Indigenous populations in Southeast Asia and elsewhere have become a major source of inspiration for more sustainable relations with the environment. Their animist orientations – attributing agency, personhood or spiritual powers to the non-human world – is what prevents them from treating the environment as a resource to be exploited. Extractive industries, by contrast, are seen to objectify the environment as an entity separate from human beings, which is what allows them to extract resources at an industrial scale. Through long-term ethnographic research in Indonesia, Malaysia, the Philippines, and Timor-Leste, this project investigates how natural resource extraction affects people’s diverse relations with the environment. However, rather than pitching indigenous communities against extractive industries, this project’s conceptual step-change consists in the development of a social interactionist framework that examines how animism and extractivism are constituted through their interactions. The hypothesis is that we find extractive logics within animist practices and that animist assumptions might also be uncovered within extractive industries. The focus on interaction allows us to determine whether animist orientations truly ‘protect’ against extractivism and how multinational corporations counteract criticism by incorporating the very logics on which this criticism is based. Ethnographic studies of resource extraction tend to be dominated by single cases, focussing on indigenous opposition and the incommensurability between indigenous and modernist ways of relating to the environment. The methodological innovation of this project lies in its comparative multi-scalar approach. Through historically informed, long-term ethnographic case studies in four Southeast Asian countries, it constructs a comparative matrix for South-to-South comparisons and examines how human-environment relations are constituted through their interactions at different scales.

Keywords: indigenous populations,southeast asia,natural resource extraction,animism,sustainability,anthropology of mining,anthropology of oil and gas,environmentalism,religion
Nature-Based Solutions Education Network (NBS EduWORLD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Coordination and support actions
Countries involved: Belgium,Lithuania,Germany,Serbia,Spain,Greece,Türkiye,Ireland,Moldova, Republic of,Portugal,France,Italy
Call: Inside and outside: educational innovation with nature-based solutions (HORIZON-CL6-2021-COMMUNITIES-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 4997583.09
EU funding (EUR): 4997583.0
Participants: 16
Project status: SIGNED

The overall objective of NBS EduWORLD is to nurture an NBS literate society, supporting a just transition to a sustainable future. For this, NBS EduWORLD will create an NBS community that facilitates synergies between NBS professionals and education providers and ensures free and easy access to NBS knowledge and resources for all. To achieve this goal, NBS EduWORLD will summarise the state of play of NBS education in Europe and evaluate the initiatives already in place, determine how to expand and replicate them and establish a basis and framework for the project itself and future initiatives, resulting in guidance and (policy) recommendations. In parallel, the project will analyse NBS demonstrators, with an educational dimension (Tier-1), across Europe (NBS EduSystems), to support the testing and improvement of approaches and resources with NBS demonstrators with no or a limited educational dimension (Tier-2) and create the means and opportunities for all NBS practitioners to engage with educators, inter alia via Tier-3 NBS EduSystems. This will be done whilst supporting the overarching goal of promoting NBS as a viable career prospect for European citizens of all ages. To adequately engage educators who are at different points on their NBS journey, the project will provide specific activities for those who are not yet familiar with the concept and benefits of NBS, and those already aware but in need of support to progress to the next stage. These activities will be scaled up/out by extensive dissemination and communication activities to maximise the project’s outreach and ensure its long-term success. Only by joining with NBS experts + Education Experts + Civil Society + supportive policies can we create an NBS EduWORLD - a community that makes a difference.
Controlled transport of water and ions in nanoconfinement (FLUXIONIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Spain,China,Netherlands,United Kingdom,Germany,Switzerland,Norway
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2826914.4
EU funding (EUR): 2705760.0
Participants: 18
Project status: SIGNED

A new technology is emerging, based on controlled transport of matter through channels with dimensions from Ångströms to nanometres. On these scales, the macroscopic description of transport phenomena breaks down, and it is necessary to integrate experiments with fully atomistic model calculations, and control non-equilibrium dynamics. Recent exciting developments in experimental and theoretical methods mean that we are finally at a stage where exploration of key processes is viable. For this focus, it is essential to train a new generation of early-stage researchers in diverse multidisciplinary and inter-sectorial skills required. This, in a few words, is the aim of FLUXIONIC network, which spans four European countries and brings together Europe’s (and world’s) leading scientists and entrepreneurs. Precisely because the topic of FLUXIONIC bridges Physics, Chemistry and Materials science, and necessitates close collaboration with emerging nanoscale industries, our major objective is to offer integrated supra-disciplinary training and a strong program of secondments with seamless cross-sectoral interactions. The DN program provides an ideal framework for creating such collaborative research/training platform. The impact of FLUXIONIC will be broad. We will train young researchers with unique and diverse profiles, who might become future leaders in the rapidly growing fields of nanoscience and nanotechnology. Our research will impact core challenges of modern society: clean water, disease treatment, sustainable energy production/storage/usage. Investing in training the new generation of researchers in this emerging field of science and technology is determinant for Europe’s future position as the world-leading power promoting sustainable development.

Keywords: non equilibrium statistical mechanics,fluid flow in nanoconfinement,water structure and dynamics,charge dynamics,nanofluidics,energy conversion,porous flow,novel 2d materials,nanochannels
Understanding the cytotoxicity of L-Phenylalanine-based non-nutritional sweeteners and how to prevent it: An interdisciplinary study on their supramolecular assembly and rationally designed inhibitors (SWEETBARRELS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

Since the beginning of food industrialization, consumers have expected products that could bring balance to the delicate relationship between flavour and nutritional requirements. In the case of sugar and sweeteners, the necessity of a low-calories sweetener capable of providing an equivalent sweet flavour without the high caloric intake inherent to sugar-sweetened drinks stimulated the food industry to develop novel artificial molecules. Sadly, consumers who wanted to “keep tabs” on their weight have faced unexpected health-related controversy, first with Cyclamate and its carcinogenic potential, later with the ups and downs on Saccharin-associated risks, and nowadays with the on-going debate about Aspartame and related substances. Besides the proposed role of Aspartame in some neurodegenerative disorders, there are questions about the impact that this, and others amino acid-based sweeteners, may have in the gut microbiome. Since the gut microbiome can affect brain health throw the gut-brain axis, understanding self-assembly can give a clearer panorama about the role of Aspartame, and structurally related non-nutritional sweeteners as Neotame, and Advantame, on neurocognitive processes. The SWEETBARRELS project focuses on understanding the self-assembly process of these molecules, since supramolecular aggregates have been proposed as one the main causes of cytotoxicity for these substances. I will use this knowledge, and previously reports of assembly modulation of amyloid structures, to design a pioneering inhibition strategy based on the synthesis of new molecules rationally designed to interfere in the aggregation process, altering the formation of potentially cytotoxic supramolecular species.

Keywords: amyloids super resolution microscopy sted flim crystallization amyloidogenic pathway