Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of a Next-Generation, Dual-Target Rabies/Flavivirus Infectious DNA (iDNA) Vaccine (RABYD-VAX)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Belgium,Belgium,Netherlands,United Kingdom
Call: Vaccine development for malaria and/or neglected infectious diseases (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 4113385.0
EU funding (EUR): 4113385.0
Participants: 5
Project status: CLOSED

Rabies is the deadliest disease on earth (99.9% fatality rate). Annually, ~58.000 people die from rabies, more than half of them are children. Many remain unvaccinated because of the high costs and the need for a cold-chain. Likewise, despite the existence of an excellent yellow fever (YF) vaccine, yearly ~30.000 people die of YF. The 80-year old low-tech production process does not allow to produce sufficient doses. There is now a real danger that major YF-outbreaks become uncontrollable. We aim at developing an efficient, safe, cheap, thermostable and easy-to-produce vaccine that can be needle-free administered, that protects against both rabies and YF, and that can be implemented in routine prophylactic paediatric vaccination. For this, we will employ our (P01a) proprietary infectious DNA (iDNA) vaccine technology. Simple, even needle-free injection of a low dose (1-10µg) of this easy-to-produce naked plasmid in mice and hamsters launches the YF vaccine virus and protects hamsters as efficiently as the commercial vaccine against lethal YF challenge. The iDNA YF vaccine will be used as vector to express relevant protective rabies antigens. Dual protection of such chimeric iDNA rabies/YF vaccine will be demonstrated against lethal rabies and YFV challenge in small animal models. Likewise, chimeric rabies/Japanese encephalitis and rabies/Zika virus iDNA vaccine candidates will be generated using this versatile platform. Next, induction of protective immunity will be demonstrated in rhesus macaques. The iDNA vaccines combine the benefits of both the YF live-attenuated vaccine (highly efficient life-long induction of immunity) and the thermo-stability, ease-of-production and the potential to customize (in response to emerging medical needs) of “classical” DNA vaccines. A path towards advanced pre-clinical and clinical development of such novel vaccines will be developed in compliance with European regulatory and WHO prequalification requirements.

Keywords: rabies,yellow fever virus,japanese encephalitis virus,zika virus,infectious dna vaccine
The one-stop-shop for urban and regional mobility (MSH)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Austria
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With cities mobility changing rapidly, new trends such as sharing-economy and smartphone penetration and challenges such as densification and pollution, commuters are dreading for solutions than can effectively integrate the diverse mobility landscape and improve their travelling experience. The Mobility as a Service (MaaS) concept is as such gaining interest as a solution to increase public and shared transport modalities and offer a smooth commuting. However, it also brings complexities as many different transport players and stakeholders have to be integrated. In response to that, we have developed Mobility Services Hub (MSH), a unique platform that provides the necessary interoperability to allow the different transport stakeholders to collaborate with each other. MSH’s platform combines all kinds of transport options from different providers and handles everything from travel planning to ticket booking and payments, reservations or billing services; and supplies reliable real-time data and incident information. Moreover, MSH will incorporate a Green Loyalty Scheme, a green-points approach to encourage and reward travellers for using eco-friendly transport modes, and health and safety services through a collection points approach. Our MSH pilot in Vienna – SMILE, was recognised as one of the most innovative projects in “The Future of urban Mobility 2.0”, in 2014. At MEP, we are experts in innovation in mobility and mobile payment. Together with our partner Fluidtime, a software developing company with over 10 years’ experience creating tomorrow’s mobility solutions, we envision cities that are smart, easy to live in and green. The global intelligent mobility market is estimated to grow from its current annual value of €57bn to over €1000bn a year by 2025, a staggering annual growth. With MSH MEP will grow x12 times and reach net benefits of €8M by 2022. Our goal is to make MSH the standard supra-national registry for all mobility services in Europe.

Keywords: transport hub,mobility as a service,connection of transport providers,interoperability
Erosion Control Oscillating Wave Energy Converter (ECOWEC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-08-31
Duration (months): 9.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Reducing the environmental impact of our economy has become an impelling necessity: climate change in fact is increasingly producing negative effects on the planet and our societies. In this frame, finding new renewable energy sources to reduce CO2 emissions and contrasting coastal erosion are among the most challenging issues, which are strictly interconnected by one element: wave power. ECOWEC is the first onshore multiple-purpose wave energy converter. Its disruptive innovation is in the performance of multiple and customizable functions at once: the device harvests and converts wave power in multiple energy forms, while protecting shoreline from coastal erosion. Thanks to the innovative application of commercial technologies and its unique design, ECOWEC is a market-oriented device: main features are modularity, scalability and financial sustainability. ECOWEC is a suitable device to be installed in ports, marinas and in any other location provided with coastal artificial structures. Our targeted end-users are mainly port and marinas authorities: by installing our device, they can ensure themselves long-term cost savings in energy expenditure, while increasing the air quality of port areas and reducing their environmental impact. By intersepting different issues, our technology is a suitable solution to catch the huge market opportunity represented by Blue Growth. Fazzini Meccanica boasts a solid engineering expertise, developed in over 20 years of activity. Every day we create innovation to deliver our clients tailor-made mechanical projects. Thanks to regular collaborations in the Offshore Oil & Gas Industry, we developed a good understanding of marine environment and offshore engineering. For this reason, Fazzini Meccanica is a suitable candidate to tackle the challenge of developing a market-oriented WEC: this project will boost the growth of our company, allowing us to double our profit over a period of 3 years.

Keywords: wave energy,blue energy,coastal erosion control,blue growth
The human retina at single cell resolution: functional architecture, disease mechanism and therapy development (HURET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Vision is of key importance for humans and losing vision has a major effect on day-to-day life. Vision starts in the retina, where an image captured by photoreceptors is processed by retinal circuits built from more than hundred cell types. Information flows from the retina via the thalamus to a number of cortical areas. Despite the large number of cortical neurons involved in vision, most blinding diseases originate in the retina and are cell-type specific. Although the vertebrate retina has a conserved cellular architecture, only a few animal models of visual diseases reproduce the pathology found in humans. Therefore, there is a major need for understanding the healthy and the disease-affected human retina. Recently my laboratory developed a set of new technologies that enable us to study the human retina, to understand its functional architecture and disease mechanism in its cell types, and so to develop therapies. Using these technologies, we first aim to describe the functional diversity as well as the function of ganglion cell types and their circuits in the human retina. Second, we aim to reveal mechanisms of cell-type vulnerability in human and mouse retinas. Third, we aim to provide proof of principle for cell type-targeted near infrared vision restoration in the human retina. Taken together, this study will provide insights into the structure, function, and mechanisms of disease of the cell types in the human visual system and will investigate a new approach to restore vision in patients with blinding diseases.

Keywords: retina,two photon imaging,human,optogenetics,organoid,neuronal circuit,vision
Highly porous collagen scaffolds for building 3D vascular networks: structure and property relationships (3DSTAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-14
End date: 2018-11-13
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This proposal concerns with the development of functional 3D hierarchical vasculature within engineered freeze-dried collagen scaffolds. The main objective is to investigate the contribution of scaffold’s pore architecture (size, shape and interconnectivity) and culture conditions, such as cell ratios in co-culture, perfusion vs. static culture and hypoxia, on the self-organisation of endothelial cells into vascular-like structures. A comprehensive 2-year, highly inter-disciplinary programme is planned encompassing processing, scaffold structure characterisation, structure-property investigation and systematic in vitro experimentation. The in vitro work will be carried out in collaboration with the REPAIR-lab in Mainz, Germany - a founding member of the European Commission Network of Excellence EXPERTISSUES. Freeze-drying process parameters will be varied to produce isotropic and anisotropic scaffolds, with pore sizes mimicking native small blood vessels. The pore architecture, in both dry and hydrated states, will be quantified via X-ray tomography and 2-photon confocal microscopy, respectively, using original methodologies. The Young’s modulus and resistance to fluid flow (permeability) of scaffolds will be measured as a function of pore architecture characteristics. A customised set-up allowing low strain measurements of Young’s modulus will be used to establish whether conventional mechanical testing is suitable. Fluid permeability will be measured by applying a constant pressure gradient. Rather surprisingly in view of permeability’s significance in nutrient diffusion and waste removal, there is only a single study on permeability. Vascular organization, maturation and functionality of optimised scaffolds will be studied as a function of pore architecture, using state-of-the-art microscopy, real-time imaging, perfusion tests, histology and a variety of biochemical assays.

Keywords: vascularisation,co culture,porous scaffolds,pore architecture,3d vascular networks,young s modulus,permeability
Getting back to Growth through Technological and Managerial Innovation (GGTMI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2020-10-31
Duration (months): 60.0
Total project cost (EUR): 1957592.0
EU funding (EUR): 1957592.0
Participants: 1
Project status: TERMINATED

The objective of the proposal is to examine ways to increase European growth through technological and managerial innovation. The technological innovation aspect is focused on examining the lifecycle of innovators and entrepreneurs across several advanced countries. We will examine the impact of financial constraints, tax and schooling policies on stimulating greater innovation. The second theme will examine by how much managerial practices can account for differences in the wealth of nations and how management quality can be improved, focusing on randomized control trials of business support polices. In addition to conducting our own surveys and drawing on administrative data, we will use Big Data techniques to measure management and corporate culture within firms. As a package this will constitute a ground-breaking piece of social science that will change the way we think about what drives prosperity across firms and countries. We are confident that this will lay foundations for better policies in Europe and elsewhere to help improve growth.
Semiconductor laser with photonic crystal reflector for energy-efficient optical links (SELAPHOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

Our information society relies to an unprecedented extent on broadband communication technologies with applications such as high-speed internet access, cloud computing, data services, multimedia broadcast systems etc. The amount of data processed by data centers continues to grow with a steep progression. We are unused to considering the energy cost of light communication, but it is huge, matching the airline industry. To meet the need for increased bandwidth, compactness, reduced power consumption and cost effectiveness, we will develop new optical sources with narrow linewidth, high-speed frequency modulation and reduced power consumption that can be utilised in modern optical links. The SELAPHOR project targets (a) the training of a young researcher in the field of photonic devices, optical communications and research commercialisation; (b) the development of novel low cost optical sources to allow both compactness and reduced power consumption of spectrally efficient optical links; and (c) the industrial validation and commercialising of the developed technology. The training programme for the researcher includes new skills in the design and fabrication of single-mode tunable sources with direct frequency modulation, characterisation and optimisation of the laser performance, and implementation of the advanced sources into telecom links. In addition, strong commercialisation and entrepreneurial skills will be developed, with keen interest from the SME partner ensuring focus on an industrial roadmap.

Keywords: semiconductor lasers,photonic crystals
Bacterial biofilms in porous structures: from biomechanics to control (BEBOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 1649861.0
EU funding (EUR): 1649861.0
Participants: 1
Project status: SIGNED

The key ideas motivating this project are that: 1) precise control of the properties of porous systems can be obtained by exploiting bacteria and their fantastic abilities; 2) conversely, porous media (large surface to volume ratios, complex structures) could be a major part of bacterial synthetic biology, as a scaffold for growing large quantities of microorganisms in controlled bioreactors. The main scientific obstacle to precise control of such processes is the lack of understanding of biophysical mechanisms in complex porous structures, even in the case of single-strain biofilms. The central hypothesis of this project is that a better fundamental understanding of biofilm biomechanics and physical ecology will yield a novel theoretical basis for engineering and control. The first scientific objective is thus to gain insight into how fluid flow, transport phenomena and biofilms interact within connected multiscale heterogeneous structures - a major scientific challenge with wide-ranging implications. To this end, we will combine microfluidic and 3D printed micro-bioreactor experiments; fluorescence and X-ray imaging; high performance computing blending CFD, individual-based models and pore network approaches. The second scientific objective is to create the primary building blocks toward a control theory of bacteria in porous media and innovative designs of microbial bioreactors. Building upon the previous objective, we first aim to extract from the complexity of biological responses the most universal engineering principles applying to such systems. We will then design a novel porous micro-bioreactor to demonstrate how the permeability and solute residence times can be controlled in a dynamic, reversible and stable way - an initial step toward controlling reaction rates. We envision that this will unlock a new generation of biotechnologies and novel bioreactor designs enabling translation from proof-of-concept synthetic microbiology to industrial processes.

Keywords: bacteria,biofilm,porous media,flow,mass transport,fluid,biofilm interactions,biomechanics,microfluidics,micro bioreactor,multiscale imaging,multiscale modelling,control engineering
Rendezvous Modelling Visiting and Enhancing (ReMoVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The “Rendezvous Modelling Visiting and Enhancing (ReMoVE)” Action is committed to design a brand new technological solution for the problem of the active removal of large faulty satellites polluting strategical terrestrial orbits. This Action will deliver the preliminary system design of a small-size, agile, versatile, and modular satellite platform capable to rendezvous, join, and de-orbit a non-cooperative Target. The game-changing approach of ReMoVE is embedded in the Enhancing concept: by exploiting recent knowledge and technology advances, such platform will act as a smart and independent additive sub-system, whose contribution will allow the Target to recover the capability to perform de-orbiting manoeuvres. The greatest challenge entailed in this concept is dealing with an unknown uncooperative Target, demanding the development of a robust and advanced autonomous spaceborne guidance navigation and control system. At the same time, the outcomes of this Action will pave the way to a future multi-player, distributed, and sustainable commitment to realize space debris removal. This Action benefits from a well-balanced multi-disciplinary inter-sectorial structure, bringing together renowned academic experts in guidance navigation and control systems from Politecnico di Milano, and specialized engineers from the successful D-Orbit company, with an Experienced Researcher who already gave key-contributions to two multi-satellite missions in low Earth orbits. The Action foresees a high-level comprehensive training plan, apt to broaden ER’s expertise and to support the fulfilment of the proposed objectives.

Keywords: active debris removal,multi satellite mission,spacecraft guidance navigation and control,spacecraft system design,autonomy