Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Methylation Profiling Diagnostic for Early Diagnosis of Alzheimer’s disease (MAP-AD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-01-01
End date: 2024-03-31
Duration (months): 39.0
Total project cost (EUR): 3568650.0
EU funding (EUR): 2408055.0
Participants: 1
Project status: SIGNED

Each year an estimated 40M people suffer from Alzheimer’s disease (AD) globally, and a new case is diagnosed every 4 seconds, leading to a substantial socioeconomic burden of over €800B annually. Despite this large need, currently there is no cure available for AD. Moreover, the clinical trial failure rate for novel AD therapies being tested is over 99%. Every failed trial leads to large financial losses for the trial sponsor, and as a result there is an urgent need to reimagine AD clinical trial design. Recently, there has been a paradigm shift in the design of AD clinical trials, with most new trials now focusing on enrollment of Prodromal AD (P-AD) patients. However, patient recruitment in the P-AD stage is challenging as current methodologies (PET, MRI) lead to a large number of false positive and negative cases. As a result, optimal stratification of P-AD patients during clinical trial recruitment, remains an unmet market need. To meet this market need, ADmit Therapeutics, an innovative diagnostics SME, aims to deliver MAP-AD: an automated epigenetic analysis platform for accurate prediction of progression status of P-AD patients. The MAP-AD platform relies on novel machine learning algorithms that can identify specific methylation patterns in mitochondrial DNA (mtDNA) isolated from the blood samples of P-AD patients. This allows for a rapid and accurate selection of patients to be enrolled into a clinical trial independent of Aβ status, for the first time. During this EIC Accelerator project, we will finalize the development of our predictive algorithms together with a dedicated software interface, and perform clinical validation in collaboration with our hospital partners to deliver a finalized platform that is ready for commercial launch. We have a strong network of partners such as Bellvitge University Hospital, Hospital Clinic de Barcelona, CITA-Alzheimer, Hospital Moisès Broggi, Hospital General de l'Hospitalet, Janssen, Roche who will be the early adopters of MAP-AD.

Keywords: alzheimer s disease,epigenetics,mitochondrial dna,clinical trials,drug development,methylation profiling,machine leearning,patient selection,clinical validation,deep tech
Plastic impacts on Ocean's biogeochemical cycles in the Anthropocene (PLOCEAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-07-05
End date: 2025-07-05
Duration (months): 36.0
Total project cost (EUR): 264669.12
EU funding (EUR): 264669.12
Participants: 2
Project status: TERMINATED

The long-term accumulation of plastic in our ocean has become a global challenge. Microplastics, and particularly those < 300 µm, are ubiquitous and persistent and get entangled in microbial organic matrices that change particles’ buoyancy, aging, and determine their bioavailability in the water for being ingested. Microplastics’ interaction with microorganisms may also change microbial communities distribution and activity, possibly perturbing biogeochemical cycles at the basis of marine ecosystems and food webs. Through primary production the ocean absorbs and converts atmospheric carbon dioxide into organic matter, further channelled to higher trophic levels by its incorporation into bacterial biomass, and thus provides up to 70% of the oxygen for life. PLOCEAN focuses on how microplastics interact with the microbial mechanisms of production and transformation of organic matter to address important research priorities: 1) plastic sources and distribution in marine environments; 2) biogeochemical processes driving plastics’ aging, transport and bioavailability affecting fish stocks and human consumption; and 3) the role of plastic in marine biogeochemical cycles that may determine changes in carbon turnover, nutrients cycling and primary productivity in coastal areas. PLOCEAN will combine field observations and laboratory studies applying the latest developments in research techniques: polymer characterization and metagenomics to study plastic-specific microbial communities, microbial contribution to particles' aging and interaction with organic matrices. PLOCEAN will also devote an important aspect to outreach and citizen science. The multi-disciplinary approach and the research questions addressed will contribute to fill knowledge gaps in the current understanding of environmental plastic fluxes, distribution, as well as impacts on biotic and abiotic marine compartments that affect biogeochemical processes behind marine ecosystem’s food webs and functioning.

Keywords: microplastics,organic matter cycling,carbon cycling,marine microbial processes,biofilm,marine coastal areas,citizen science
Heterogenous Photo(electro)catalysis in Flow using Concentrated Light: modular integrated designs for the production of useful chemicals (FlowPhotoChem)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Uganda,Germany,Germany,Spain,Spain,Ireland,Ireland,Switzerland,Hungary,Hungary,Netherlands,Netherlands,United Kingdom
Call: Photocatalytic synthesis (RIA) (H2020-NMBP-ST-IND-2019, 2019)
Start date: 2020-06-01
End date: 2024-05-31
Duration (months): 48.0
Total project cost (EUR): 6993315.0
EU funding (EUR): 6993315.0
Participants: 17
Project status: SIGNED

The aim of this project is to develop and model an integrated modular system based on continuous-flow heterogeneous photo(electro)catalytic reactors to produce relevant chemicals such as ethylene in the chemical sector, precursor to "green plastics" and many other high-value chemicals using abundant resources such as water, carbon dioxide and light. We aim at delivering cost-efficient small-scale systems for intermittent operation to respond to the needs of rural, isolated territories, and distributed manufacturing. Novel multifunctional photo(electro)catalytic materials integrated into practical and scalable reactors are required in Europe to maintain the technological leadership in chemical manufacturing, while ensuring the deployment of sustainable processes which meet circular economy and green industry for a low-carbon future. FlowPhotoChem will use the expertise of the partners to design, model, construct and validate an integrated modular system with improved energy efficiency and negative CO2 emissions, since concentrated CO2 will be valorised to high-value chemicals. The integrated system will be studied from a life cycle analysis perspective to quantify such effects, and to include a techno-economic study to quantify the cost of the technology and compare with comparable renewable solutions for the production of the same/similar chemicals.

Keywords: materials engineering,flow reactors,modelling,solar chemicals,photoelectrochemistry
The impact of cues and negative consequences on decision making: the role of the insular cortex (Island in the brain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Psychiatric disorders such as addiction, depression and anxiety disorder are characterized by suboptimal decision making (DM) due to aberrant processing of negative information. However, it remains unclear which brain processes underlie suboptimal DM. One candidate brain region involved is the insular cortex (insula), which has been implicated in DM and in several psychiatric disorders. Laboratory tasks to assess DM in humans closely mimic real-life situations, providing participants with cues to guide their decisions, which can lead to winning or losing money, much like weighting information about risks and benefits when choosing between investing in stocks or bonds. However, the technology available to study the human brain is limited, whereas experiments with rodents allow for a detailed and fine-grained understanding of brain function. Importantly, in order to translate results between rodents and humans, the tasks used to assess behaviour need to be comparable, but there are currently no tasks in rodents to study cue-guided DM in the face of punishment. During the fellowship, I will study the involvement of the insula in DM when using cues to inform rats about potential punishments and benefits. To achieve this, I will: 1) Develop a novel behavioural task to assess “cue-guided risk/punishment decision making” in rats. 2) Assess the contribution of the insula by perturbing neural signalling in this brain region, and the network it is embedded in. The novel task has tremendous translational value in that it parallels tasks used in human populations and mimics real-life decisions. Therefore, the results of the project are relevant for testing the efficacy of treatment strategies targeted at the insula to alleviate psychiatric disorders such as anxiety disorders and addiction.

Keywords: risk,reward,punishment,cues,decision making,prefrontal cortex,insular cortex,striatum,nucleus accumbens,gambling,addiction,rats
Ultra-Low Power Event-Based Camera (ULPEC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,France,France,France,Netherlands
Call: SSI - Smart System Integration (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 4862256.25
EU funding (EUR): 3876396.0
Participants: 10
Project status: CLOSED

The long term goal of ULPEC is to develop advanced vision applications with ultra-low power requirements and ultra-low latency. The output of the ULPEC project is a demonstrator connecting a neuromorphic event-based camera to a high speed ultra-low power consumption asynchronous visual data processing system (Spiking Neural Network with memristive synapses). Although ULPEC device aims to reach TRL 4, it is a highly application-oriented project: prospective use cases will be studied and an application roadmap will be developed, by considering interoperability for an integration in “systems of systems” as well as the definition of upper power consumption limits depending on future application. The project consortium therefore includes an industrial end-user (Bosch), which will more particularly investigate autonomous and computer assisted driving. Autonomous and computer assisted driving are indeed a major disruption in the transport and car manufacturing sector. Vision and recognition of traffic event must be computed with very low latency (to improve security) and low power (to accommodate the power limited environment in a car, such as power budget and heat dissipation). Substantial impact on innovation capacity and creation of market opportunities is expected under the ULPEC project: four enterprises (two SMEs) participate to the project. The ULPEC project is an opportunity for European companies such as TSST to increase the competitiveness and increase the global market share in manufacturing tools for complex oxide thin film synthesis. Besides, a compact, low-power vision system based on the technology intended to be developed in this project would generate a distinct competitive advantage over conventional solutions and would clearly boost Chronocam’s market potential. ULPEC is also an opportunity for SMEs to develop stronger collaboration with the industrial leaders involved in the project, such as IBM and Bosch.

Keywords: ferroelectric memristor,neuromorphic engineering,event based camera
International cooperation on Raw materials (INTRAW)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Coordination and support actions
Countries involved: Ukraine,Germany,Ireland,Australia,South Africa,Spain,Italy,Germany,Austria,Austria,Spain,Switzerland,Serbia,Belgium,Finland,Greece,Croatia,Hungary,Poland,Slovenia,Sweden,Russian Federation,Hungary,France,Czechia,Netherlands,United States,United Kingdom,Portugal,Portugal,Canada,United Kingdom,United Kingdom,Portugal
Call: Strategic international dialogues and cooperation on raw materials with technologically advanced countries (H2020-SC5-2014-one-stage, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 2111375.0
EU funding (EUR): 2104800.88
Participants: 42
Project status: CLOSED

INTRAW will map and develop new cooperation opportunities related to raw materials in Australia, Canada, Japan, South Africa and the United States, addressing: • Research and innovation; • Raw materials policies and strategies • Joint educational and skills programmes; • Licensing and permitting procedures; • Data reporting systems; • Exploration, extraction, processing and recycling practices; • Management and substitution of Critical Raw Materials. The outcome of the mapping and knowledge transfer activities will be used as a baseline to set and launch the European Union’s International Observatory for Raw Materials as a definitive raw materials intelligence infrastructure, operating internationally. The Observatory will be a permanent body that will remain operational after the project completion, with a clear strategy and management approach, aiming for the establishment and maintenance of strong long-term relationships with the world’s key players in raw materials technology and scientific developments. The Observatory will not only continuously monitor cooperation possibilities but will also actively promote these via the establishment of dedicated bilateral and multilateral funding schemes and incentives for raw materials cooperation between the EU and technologically advanced countries outside the EU.

Keywords: raw materials,international cooperation,research,education,industry
Multi-dimensional interferometric amplification of ultrashort laser pulses (MIMAS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 2373750.0
EU funding (EUR): 2373750.0
Participants: 1
Project status: CLOSED

Ultrafast lasers, which allow the concentration of light in space and time, have been instrumental in revolutionizing industrial production technologies, medical applications and cutting-edge fundamental research. A common demand for many applications is the combination of maximum pulse peak powers with maximum average powers, in extreme cases involving petawatt (PW) peak powers and megawatt (MW) average powers. Additionally, these parameters must be achieved together with an optimum beam quality and high efficiency. The MIMAS project aims to address these demands and enable new realms of performance for ultrafast lasers. The basic idea is spatially and temporally separated amplification of ultrashort laser pulses followed by coherent combination. This overcomes all the scaling limitations known in single-emitter systems. Moreover, the spatially separated amplification will be developed to an integrated and highly compact configuration: an ytterbium-doped multicore fiber. In addition, it is proposed that a sequence of pulses be amplified with an encoded phase pattern, causing a coherent pulse stacking at the system output. The targeted laser pulse parameters are completely beyond the scope of current laser technology and therefore able to revolutionize many applications. The target is to generate a pulse energy of >1J at 10kHz repetition rate, i.e. an average power of >10 kW, with a wall-plug efficiency of >10%. Together with a pulse duration of <200fs, such performance results in a pulse peak power of >5 TW in a scalable architecture. This outstanding performance, which is three orders of magnitude above the capabilities of today’s laser systems, is emitted from only two fibers and features excellent beam quality. I am deeply convinced that such an ultrafast laser source will be the key element in a number of experiments in modern sciences; not only in fundamental physics but also in biology and medicine, it will stimulate seminal discoveries and breakthroughs.

Keywords: ultrafast fiber lasers,high average and high peak power lasers,coherent combination of ultrafast lasers,fiber design and fabrication
Politics of Rulemaking, Orchestration of Standards, and Private Economic Regulations (PROSPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-12-29
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

PROSPER is an interdisciplinary project that seeks to understand the politics of rule-making in the global trade regime. It primarily aims to examine how the growth of internationalization of production networks enables private actors – i.e. multinational companies (MNCs) – to be active in the shaping of international economic policies, such as trade agreements and regulatory standards. PROSPER will primarily investigate the extent to which MNCs are able to orchestrate political mobilization of their subsidiaries for coordinated lobbying and impose rules and standards upon firms along their supply chains. Applying international political economy (IPE) insights from the fields of political science, economics, and international law, the projects proposes that firms’ globalization strategies and their degree of integration into global production networks significantly affect their ability to be active in shaping global rules and standards. In order to test the empirical implications of the proposed theory, PROSPER will employ a mixed-method research design using quantitative analysis and in-depth case studies. The project will construct a comprehensive new dataset of MNCs and triangulate the results achieved through statistical analysis via comparative cases studies. As a result, by combining insights from political science, economics, and international law, the project will help us understand the dynamics of economic globalization and the role of private actors in the global trade governance.

Keywords: global value chains gvcs,regulatory standards,trade policy,preferential trade agreements ptas
Photon Counting Spectral Computed Tomography (PCSCT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 3441750.0
EU funding (EUR): 2409225.0
Participants: 1
Project status: CLOSED

Due to its speed, accuracy and availability Computed Tomography (CT) is a routine tool for imaging of cardiovascular disease, stroke, cancer and trauma injuries; every year over 100 million patients are examined using CT, making it one of the most common medical imaging procedures. Despite a significant development, current CT detectors are unable to obtain sufficient spectral information and have a limited spatial resolution. This leads to image artefacts and limited visualization of important details. Healthcare providers are thus forced to use more expensive and slower modalities like MRI and PET, translating in increased healthcare costs and risk since time to treatment is prolonged. Our solution is a novel photon counting spectrally resolved detector, developed and fully owned by the SME Prismatic Sensors. The technology offers a factor two higher spatial resolution, elimination of artefacts and increased dose-efficiency compared to state-of-the-art clinical CT scanners. Millions of people around the world would benefit from our technology through improved diagnostics and speed of care. In addition, radiation dose and the associated risk is dramatically reduced. The project will result in a fully tested and validated photon counting spectral CT detector ready for commercialization. The technology and the added clinical value will be validated and compared with state-of-the art in a clinical trial by radiologists at the Karolinska University Hospital. As an outcome, Prismatic Sensors expects the new patented detector technology to be the future choice for some or all the major global vendors. This will support Europe's position as a world-leader in medical innovation and healthcare technology, as well as improve hospital efficiency and save healthcare costs. Most importantly, it will have a positive impact for the survival odds for a large number of patients worldwide.

Keywords: medical technology,computed tomography,stroke diagnostics,cardiovascular diagnostics,cancer diagnostics,trauma injuries,photon counting,spectral ct