Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LI-ION CELL PILOT LINES NETWORK (LiPLANET)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Germany,Austria,Spain,Germany,Belgium,Belgium,France,Netherlands
Call: Network of Li-ion cell pilot lines (H2020-LC-BAT-2019, 2019)
Start date: 2020-01-01
End date: 2022-03-31
Duration (months): 27.0
Total project cost (EUR): 1998636.25
EU funding (EUR): 1998636.25
Participants: 8
Project status: CLOSED

The development of cost-effective, reliable, and high-performance battery cells will be essential to strategic sectors in Europe such as the automotive industry (electro-mobility) and the electric power sector. However, the world production of battery cells is largely dominated by Asian companies. To reduce the gap with the battery cell production in Asia and become a world leader, the EU must have independent capacity to develop, upscale and produce battery cells. LiPLANET aims to build a more competitive Li-ion battery cell manufacturing ecosystem and increase the production of Li-ion cells towards industrial scale, by bringing together the most relevant European Li-ion cell pilot lines and the main stakeholders of the battery sector. The creation of a network of Li-ion cell pilot lines will allow to exploit synergies between pilot line operators, identify knowledge and equipment gaps, organise joint trainings as well as, favour collaboration with industry and academia, and facilitate the access to market. For this purpose, different activities have been designed: -the mapping of the European Li-ion cell pilot lines and the implementation of a network, -the creation of a standardised legal framework and a data exchange platform for the cooperation between industry, academia and pilot lines, -a round-robin test to compare qualification methods, -the development of a roadmap to reach industrial scale production. LiPLANET’s consortium is formed by recognised entities in this field. In that sense, they will be in a good position to create awareness of the network. The grounds of the project and sustainability of the network (based on a series of services provided to the battery industry) were first discussed during the European Battery Cells R&I workshop in January 2018 in Brussels, and during a dedicated workshop in September 2018 in Frankfurt.

Keywords: li ion cells,pilot lines,industrial scale up,collaboration network,data exchange
Water at Oxide Surfaces: A Fundamental Approach (WatFun)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2499787.0
EU funding (EUR): 2499787.0
Participants: 1
Project status: SIGNED

The water/oxide interface, and the molecular processes that happen there, regulate everything from environmental chemistry and the sequestration of CO2 to the cohesion of man-made structures. The properties of individual surface sites govern reactivity, so probing chemistry at this level is necessary to better understand natural processes, and to ultimately improve technologies where this interface plays a central role. In this project, we take a radically new approach to investigate the water/oxide interface at the most fundamental, the atomic, scale: we have found a way to integrate bulk liquid water into ultrahigh vacuum (UHV) setups, where an arsenal of highly-developed techniques is available to investigate surfaces. This provides the opportunity to accurately determine fundamental quantities that were hitherto inaccessible, and to obtain clear-cut experimental results for interpreting and predicting molecular-scale processes. In this project, we seize this opportunity to develop novel measurement concepts, and apply them to minerals. Following a broad work plan we will: measure the surface tension of neat water and the surface free energies of solids with unprecedented purity; devise a method to determine, site-by-site, the intrinsic proton affinity, the fundamental property that determines the point of zero charge of oxides in solutions, and their Brønsted acidity in gas-phase reactions; investigate, at the atomic scale, how liquid water affects surface structure, and how oxides become hydroxylated, dissolve, and ‘age’; discover how ice nucleates on the mineral aerosol surfaces that are crucial in cloud formation; study how dissolved CO2 reacts with natural minerals, which affects the global carbon cycle; address the hydrated oxides that form the basis of cements in concrete. While this project focuses on providing a fresh view on environmentally-relevant chemistry, we also show how our approach can make an impact in a much wider range of areas.

Keywords: surface science,oxide surfaces,surface chemistry,scanning probe microscopy,mineral and geochemistry,catalysis heterogeneous,photo,and electrocatalysis,properties of neat water
Sino-Iranica: Investigating Relations Between Medieval China and Sasanian Iran (SINOIRAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

An investigation of Sino-Iranian connections from the third to tenth centuries, with a particular focus on political, religious and material exchanges between China and Sassanian Iran. The aim will be to build a bridge between modern Sinology and Iranology and to further build our understanding of the history of Sino-Iranian relations in close coordination with Iranologists in Italy and Europe. The project will aim to highlight Sino-Iranian relations as having been significantly more important than is normally recognized, and to provide new knowledge that will be useful to both Sinology and Iranology. This two-year project will excavate primary and archaeological sources in Chinese while documenting modern scholarship on Sino-Iranian relations, especially in Modern Chinese and Japanese. The project will make great use of the digitized and searchable corpus of classical Chinese, and reevaluate the roles of Iranian religions in medieval China. The findings and data from this study will be digested and presented as a single monograph. The proposed project will be actively interdisciplinary. It will involve the research, a Canadian Sinologist trained in Japan and the Netherlands, being hosted by Iranologists in Italy. Such an arrangement will allow for gainful two-way exchanges of knowledge and skills.

Keywords: china iran sasanian dynasty tang dynasty persian chinese pahlavi chinese history sogdian zoroastrianism christianity manichaeism materia medica silk road sinology iranology
Understanding the Biology of Human Enteroendocrine Cells (GutHormones)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Switzerland,Netherlands
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2733150.0
EU funding (EUR): 870285.31
Participants: 2
Project status: SIGNED

Intestinal epithelium consists of self-renewing crypt-villus units and contains 6 mature cell types: Enterocytes, goblet cells, Paneth cells, Tuft cells, M cells and Enteroendocrine cells (EECs). The rare EECs are subclassified by the (>20) hormones they produce. Generally, EECs sense intestinal content and regulate gastrointestinal activity, systemic metabolism and food intake. While one EEC hormone, GLP1, has been developed into a highly successful diabetes drug, a paucity of laboratory models has complicated human EEC studies. Previously, we identified adult crypt stem cells by the novel marker Lgr5, and established conditions to grow ‘gut organoids’ from these. By single cell RNA sequencing, we have resolved the complex EEC subtype hierarchy into 5 lineages. Our studies underscore significant differences between mouse and man, not unexpected given the divergent diets and metabolism. Gut organoids can be manipulated to contain all EEC lineages. We have created a set of human organoids in which the individual hormones are fluorescently tagged by CRISPR. The current proposal exploits the technologies described above, as well as our ‘Human EEC Atlas’ to generate a detailed picture of the biology of EECs, their triggers, their interconnectivity and their products. To this end, I propose to: 1. Complete the Human EEC Atlas and hormone-tagged organoid set for stomach and colon. 2. Resolve how individual EEC subtype fates are set. 3. Resolve which luminal receptors and ligands allow sensing of nutrient components and microbial products 4. Resolve cross-regulation of EEC subtypes. 5. Investigate systemic effects of novel EEC products in mouse knockout models. Successful completion of this proposal will generate a comprehensive characterisation of EECs. This will inspire new therapeutic approaches to reshape the EEC landscape for treatment of metabolic diseases (obesity, diabetes, fatty liver disease, atherosclerosis) and other consequences of the Western-type diet.

Keywords: human enteroendocrine cells,organoids,hormones,microbiome
Resolving the molecular basis underlying convergent evolution of DODA enzymes in the betalain synthesis pathway (ConvergentDODA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

As sessile organisms, plants have evolved a diverse array of specialized metabolites to respond to their environments. Specialised metabolites are frequently restricted to particular plant lineages, such as the specialised betalain pigments, which are unique to the flowering plant order Caryophyllales - betalains will be familiar as the colour of beetroot. However there are also striking examples of convergent evolution, with the same specialized metabolites emerging independently in different lineages. The host laboratory has recently shown that the betalain biosynthesis pathway has evolved multiple times within Caryophyllales. Underpinning four convergent origins of betalain pigmentation, the central enzyme in the betalain pathway, 4,5-DOPA-extradiol -dioxygenase (DODA), has evolved four times via gene duplication and neofunctionalization. Preliminary data indicate that DODA enzymes from different origins have distinct kinetic profiles, of significance to biotechnology. In the proposed research, I will elucidate the molecular basis underlying the repeated evolution of L-DOPA dioxygenase activity, and resolve the molecular evolutionary trajectories underlying different enzymatic catalytic profiles across different origins of betalain synthesis. Convergent evolution provides a natural experiment in understanding the genetic basis of repeated emergence and optimization of a metabolic pathway. In exploring the molecular basis of the convergent evolution of high DODA activity, I expect to address many central questions in evolutionary biology, including the respective roles of parallel evolution, epistasis, adaptive constraint, and contingency, in the evolution of molecular complexity.

Keywords: convergent evolution,l dopa 4,5 dioxygenase,metabolic engineering,molecular,convergence,protein characterisation,molecular evolution,enzyme evolution
Relaxation dynamics in closed quantum systems (DYNAMIQS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Statistical mechanics, a century-old theory, is probably one of the most powerful constructions of physics. It predicts that the equilibrium properties of any system composed of a large number of particles depend only on a handful of macroscopic parameters, no matter how the particles interact with each other. But the question of how many-body systems relax towards such equilibrium states remains largely unsolved. This problem is especially acute for quantum systems, which evolve in a much larger mathematical space than the classical space-time and obey non-local equations of motion. Despite the formidable complexity of quantum dynamics, recent theoretical advances have put forward a very simple picture: the dynamics of closed quantum many-body systems would be essentially local, meaning that it would take a finite time for correlations between two distant regions of space to reach their equilibrium value. This locality would be an emergent collective property, similar to spontaneous symmetry breaking, and have its origin in the propagation of quasiparticle excitations. The fact is, however, that only few observations directly confirm this scenario. In particular, the role played by the dimensionality and the interaction range is largely unknown. The concept of this project is to take advantage of the great versatility offered by ultracold atom systems to investigate experimentally the relaxation dynamics in regimes well beyond the boundaries of our current knowledge. We will focus our attention on two-dimensional systems with both short- and long-range interactions, when all previous experiments were bound to one-dimensional systems. The realisation of the project will hinge on the construction on a new-generation quantum gas microscope experiment for strontium gases. Amongst the innovative techniques that we will implement is the electronic state hybridisation with Rydberg states, called Rydberg dressing.
Novel MAterial and Process Design for ReVerse Electrodialysis-Water ELectrolysis Energy System (MARVEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 142720.8
EU funding (EUR): 142720.8
Participants: 1
Project status: CLOSED

Development of renewable energy resources that can address energy and environmental issues is currently the top global challenge. Reverse Electrodialysis (RED) is a highly innovative technology for conversion of salinity gradient energy into electricity. Water electrolysis is a promising option for hydrogen production from renewable energy resources. Recently, a novel approach combining RED and Alkaline Polymer Electrolyte Water Electrolysis (APEWE) was reported for sustainable hydrogen production. However, this process achieved low efficiency: RED suffers from the negative impact of multivalent ions on power generation, whereas APEWE lacks highly conducive and stable membrane separators and polymer binders. The MARVEL project aims to i) endow monovalent ion selectivity for RED membranes to reduce the influence of multivalent ions ii) develop novel, fully characterized membrane separators and polymer binders for APEWE iii) test RED-APEWE process with these new materials iv) perform a techno-economic assessment for commercial feasibility. The ultimate goal of MARVEL is to broaden the knowledge and expertise of the researcher, Dr. Ramato Ashu Tufa, through high-quality research training in the emergig area of renewable energy involving multidisciplinary investigation approaches and intersectoral secondments. This allows him to establish a long-standing relationship with his institute and increase his professional network across Europe. An effective dissemination of project results and knowledge will be implemented through presentations of results in major conference, seminars, publications in high-impact peer reviewed journals, project web page, open days etc. Profound outputs from MARVEL will significantly contrubte towards establishment of a strong scientific and technical base for European science and technology, foster the competitiveness and growth of EU economy with a positive impact on the major objectives of energy policy for sustainability and security.

Keywords: renewable energy,reverse electrodialysis,energy storage,alkaline water electrolysis,integrated system,polymer electrolytes,techno economic assessment
Uncovering the Mechanisms Behind Adaptive Gene Expression Switching in Malaria Parasites (MALSWITCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany,Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1434330.0
EU funding (EUR): 1434330.0
Participants: 2
Project status: SIGNED

The malaria-causing parasite Plasmodium falciparum has evolved a strategy of clonally variant gene expression to control essential biological processes like antigenic variation and sexual commitment during its persistent blood-stage infection of the human host. Heritable epigenetic silencing of the underlying specialized gene families ensures the limited expression of only a subset of these genes at any time. Switching the expression of individual clonally variant genes enables the parasite to rapidly adapt to changes in its environment, evade the immune system and switch its cell cycle to the development of mosquito-transmissible gametocyte stages. Expression switching of these clonally variant genes therefore represents a key strategy for parasite survival and underlies the evolutionary success of this deadly pathogen. Despite decades of research, the molecular mechanisms coordinating this adaptive gene expression switching are not understood. In my recent research, I developed a unique experimental tool, which for the first time allows the conditional expression switching of endogenous genes in the parasite. I will combine this system with novel CRISPR/Cas derived methodology and proximity-based labelling approaches to deliver the first systematic identification and characterization of the molecular mechanisms controlling epigenetic gene expression switching. The experiments outlined in the proposal will reveal the core of the molecular machinery underlying this fundamental process and elucidate regulatory mechanisms that allow the parasite to translate environmental signals into adaptive switching of clonally variant genes. This will transform our understanding of the molecular mechanisms driving adaptation of this deadly parasite and in the long run might contribute to the design of intervention strategies that P. falciparum is unable to adapt to.

Keywords: plasmodium falciparum,clonally variant gene expression,epigenetics,long non coding rna,crispr
Adaptive and personalized neuromotor rehabilitation of persons with Multiple Sclerosis: from characterization to exploitation of residual sensorimotor abilities using a body-machine interface (REMAp)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-04
End date: 2023-01-03
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

The project AIMS AT developing and validating a novel approach to neuromotor rehabilitation of persons with Multiple Sclerosis (PwMS), rooted in the physiological mechanisms of recovery and based on Body-Machine Interfaces (BoMI). This project is INNOVATIVE in that it explicitly takes subjects’ impairments into account, first characterizing it and then inherently adapting and individualizing the rehabilitative interventions. The project is based on the IDEA that after a neurologic disease or during a rehabilitative training all the nervous system (from the periphery to the brain) go through a reorganization and knowing these changes can be exploited to design more effective and tailored intervention. Muscle synergies in combination with kinematic synergies will be used to develop a MS- specific tool for a complete functional evaluation, to monitor progress of the disease and effects of treatments, and they will be use to design a BoMI that will exploit the residual mobility with patient-specific exercises helping PwMS to reach their full functional potential. Because of their adaptive nature, BoMIs will benefit PwMS with different degrees of impairment adapting to their changing conditions (worsening due to the disease progress or improving due to therapy). The project will evaluate BoMI training-induced reorganization in the brain and spinal cord with innovative imaging techniques. This will allow building solid foundations for a comprehensive understanding of use-dependent plasticity of the sensorimotor cortex and sensorimotor tracts in healthy subject and in PwMS. The expected outcome will be a novel method and a class of highly adaptive, personalized devices that not only maximize the restoration of functional performance, but also promote the functional reorganization of body abilities.

Keywords: multiple sclerosis,rehabilitation,motor recovery,motor learning