Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamic river catchments in a Global Change context: assessing the present, preparing for the future (SEDAHEAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1498846.0
EU funding (EUR): 1498846.0
Participants: 1
Project status: SIGNED

In a Global Changing world sediment regime has emerged as a dominant actor in the modification of river catchments. The sediment regime refers to the sediment budget (amount, type and timing of sediment inputs, outputs and storage) of a river system as well as the way water and sediment interact to drive river conditions. Studies of sediment regime assessing the impact of Global Change are scarce and traditionally relies on deterministic approaches. However, at any given river catchment section, a complex imprint in the spatial-temporal distribution of sediment regime is observed. This imprint is caused by the temporal and spatial uneven production, storage activation and transport of sediments. Pure deterministic (and thus partial) solutions are not accounting for the natural variability of sediment regime and the inherent uncertainty due to Global Change. This means we are potentially missing half the story and that our attempts to forecast the current and future evolution of rivers areas, at both catchment- and reach-scale, may be more wrong than right. The tenet of this proposal is to describe and determine the Global Change impacts on sediment fluxes at all scales relevant for river catchment management by means of a modelling approach that can account for natural stochasticity and Global Change uncertainty. Three main and novel research questions have been identified and need to be addressed: (i) how (and how strongly) the headwaters control the main features of sediment regime; (ii) how to model sediment fluxes by means of a forecasting model capable to reproduce fluctuating (and thus realistic) sediment regime characteristics; and (iii) how to identify and incorporate the Global Change impacts on sediment regime modelling to assist in fostering a more robust river catchment management. This proposal contributes to the 13th UN Global Goal “Climate Change” and to the Horizon Europe mission: “Adaptation to Climate Change including Societal Transformation”.

Keywords: sediment regime river morphology modelling river catchment global change environmental risk assessment
Comprehensive Analysis of RBM20-induced Dilated Cardiomyopathies using Omics Approaches and Repair Interventions (CARDIOREPAIR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,Czechia
Call: EIC Pathfinder Challenge: Cardiogenomics (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 4617351.25
EU funding (EUR): 4617351.25
Participants: 3
Project status: SIGNED

In CARDIOREPAIR, we aim to identify and repair disease-causing variants in dilated cardiomyopathy (DCM), the major contributor to heart failure. We focus on the gene RBM20 mutated in patients with a highly penetrant and aggressive form of familial DCM. We will create a comprehensive map of all possible RBM20 variants that can cause DCM and develop a therapeutic approach for mutations with the strongest effect size. Enabled by a multitude of new technologies developed in our groups, the primary goal is to characterize the complete spectrum of amino acid mutations in RBM20 by high-throughput saturation mutagenesis screens. Combined with functional readouts and multi-omics analysis of downstream processes, we will classify and score the pathogenicity of each individual mutant (objective 1). To this end, we will cover both the known DCM-causing RBM20 variants, as well as those that have not been identified in patients yet. Each mutant, represented by a typical transcriptomic, proteomic, phosphoproteomic, and microscopic fingerprint, will guide us in finding novel class-specific therapeutic strategies to revert the deviant phenotype back to the healthy state. For a subset of mutants representing each identified mutation class, we will generate mouse models and investigate changes in heart physiology and ultrastructure linked to the altered ‘ome’ profile. Our second goal is to establish a class-specific therapeutic approach for the treatment of patients harboring RBM20 mutations (objective 2). We will implement our advances in muscle-specific gene editing, focusing on prime editing and nanobody-guided approaches to specifically tackle the mutations leading to RBM20 translocation. This proposal serves as a blueprint for going from variant identification to therapy in an accelerated fashion by harnessing and combining the power of high-throughput functional genomics and bioengineering and therefore is widely applicable to other cardiovascular diseases (CVD).

Keywords: dilated cardiomyopathy,rbm20,saturation mutagenesis screen,prime editing,multi omics profiling
Confident®, the digital simulation platform that revolutionizes cardiovascular interventions (Confident)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 9085800.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Confident is a disruptive cloud-based platform for digital planning of cardiovascular interventions. Today, many patients do not have access to treatment as their case is considered at too high risk for surgery. Created in 2017, PrediSurge has developed a unique AI-based solution that enables physicians to select the best therapeutic strategy for a specific patient. Confident®builds 3D virtual models of patients’ anatomy and implants with real-life biomechanical behavior. For the 1st time, physicians can simulate procedures to predict and prevent post-operative complications. Our patented digital twin technology completely redefines planning potentialities of endovascular aneurysms repair and transcatheter mitral valve repair. With EIC, PrediSurge will accelerate its business development to become a world leader in predictive software solutions for cardiovascular precision medicine. We will digitalize cardiovascular healthcare to change the lives of millions of patients.

Keywords: biomechanics,medical imaging,machine learning,signal processing,modelling algorithms,scientific computing,advanced computing,chronic disease,cardiac and cardiovascular systems,preventive medicine,predictive medicine,aortic repair,endovascular interventions,minimally invasive procedures,stent grafts,medical devices,digital services,numerical simulation,digital twins,digital health
How to make a limb: a new insight using three-dimensional synchrotron palaeohistology (LimbEvolution)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1856316.0
EU funding (EUR): 1856316.0
Participants: 1
Project status: SIGNED

Tetrapods, i.e. four-limbed animals, are the only backboned animals to have truly conquered the land, and have achieved worldwide distribution in a wide range of environments. Several fish groups have attempted to colonise terrestrial habitats (e.g. mudskippers among ray-finned fish; lungfish among lobe-finned fish) but only tetrapods were able to initiate a large-scale radiation. What is the key to this success? Our limb skeletons have obviously played a crucial part, by allowing us to walk and support our weight outside of the water, but that is not their only function. For example, at some point during the early evolution of tetrapods, the haematopoietic (blood cell-producing) tissue transferred to the bone marrow; it has been suggested that this protected the production of blood cells from UV radiation and made it more efficient. This extraordinary multifunctionality evolved through successive microanatomical innovations, beginning 400 million years ago. The underlying reasons and processes are still unclear, partly because traditional palaeontological techniques have not been able to uncover the crucial changes in 3D microarchitecture from fin to limb. I will overcome these limitations using a novel cross-disciplinary approach based on state-of-the-art, three-dimensional, tomographic imaging techniques at high resolution. I will combine 3D modelling with virtual simulations of biomechanical stress, evidence of biomarkers and functional genomics to provide the first comprehensive picture of three major steps in the limb evolution: 1) the shaping of our limb into three segments, 2) the origin of blood-cell production in limb bones, and 3) the role of ossified mineralised ends in the exceptional locomotor radiations of tetrapods. This project will illuminate the process by which our limb skeletons became, not just structural props and locomotory levers, but essential powerhouses of cell manufacture without which we cannot survive.
Testing solid earth climate connections through mid ocean ridge time series (T-SECTOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,United States
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-10-01
End date: 2029-09-30
Duration (months): 72.0
Total project cost (EUR): 13982850.0
EU funding (EUR): 13982850.0
Participants: 3
Project status: SIGNED

A central problem of understanding the Earth system is quantifying climate-solid Earth feedback that requires time-series studies. One important time series is the climate (sea level) record that shows transitions between ice ages and warm periods for the last millions of years, involving vast mass transfer between continents (ice load) and oceans. Volcanism is sensitive to such pressure changes, but its response to glacial cycles is largely unknown for the global mid-ocean-ridge (MOR) system, where 80% of Earth’s volcanism occurs. Models of MOR response to sealevel fluctuations predict changes in crustal thickness, chemistry of lavas and hydrothermal activity. Establishing high-resolution time series on MORs, however, has previously not been possible, because the sea floor is rapidly covered by sediment as it moves away from the MOR and thus cannot be directly sampled. Recent studies, however, show MOR eruptions deposit samples of lava as glass on nearby sediments for up to 100 ka. These carbonate-rich sediments can be precisely dated by oxygen isotope stratigraphy and provide an archive of ridge eruptions (glasses) and hydrothermal activity (trace metals) in the sediments that can be sampled by gravity coring. Through closely spaced new cores to be retrieved during multiple research cruises, a high-resolution time series of volcanism and hydrothermal activity can be achieved and directly linked to the climate record, whereas seismic techniques can be used to determine variations in crustal thickness over time. We propose to obtain integrated data sets for all these processes from slow, intermediate and fast spreading ridge segments over the past 1.5 Ma in unprecedented detail. The results of these glass, sediment and crustal thickness time series will allow us to unequivocally test the influence of glacial cycles on MOR processes and will provide the first high-resolution time series of ocean ridge magmatism, opening up a new frontier of scientific exploration.

Keywords: paleoceanography,hydrothermalism
Ultimate fracture toughness through thickness engineering (HAPI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The design of critical structural metallic components in the aeronautic, biomedical, nuclear or pipeline fields is often dictated by a fail-safe criterion established in the context of fracture mechanics. The design must prevent any pre-existing crack to propagate under nominal but also sometimes accidental loads. In this context, the primary material property is the fracture toughness quantifying the resistance to crack initiation. In ductile metals, the fracture toughness depends on plate thickness with a peak value attained at an intermediate thickness in the range of a fraction of a millimetre up to ten millimetres or more. Although this thickness dependence is known since the 60’s, the literature is very silent regarding the peak fracture toughness value, about what sets its magnitude and about the corresponding optimum thickness. Hence, there is no definitive rational about how to use or account for such an optimum fracture toughness in structural design. The vision of HAPI is that the fracture resistance of critical metallic structural components can be significantly enhanced by selecting and/or controlling the plate thickness for thin-walled applications and the constituent plate thickness for thick laminates. In particular, metal laminates with optimum thickness of the constituents, selected for their high strain hardening capacity will lead to unattained levels of cracking resistance. This will require generating a range of new experimental fracture data, performing complex 3D finite element simulations relying on a rich micromechanical model with new enhancements, extending the materials selection approach, exploring the processing/assembling of novel ultra-tough metal laminates up to a radically new concept of laminate pressure vessel. Major gains are expected on the weight of structures, potentially up to a factor five if fracture toughness is the dominating design factor, and this, without changing the chemistry or inventing new microstructures.

Keywords: fracture of materials,damage,fracture toughness,mechanical testing,materials selection,cracking,strain hardening,plasticity,metallic alloys,laminates,micromechanics,assembly
Quality Control of Damaged Proteins at Synapses (SYNDAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499915.0
EU funding (EUR): 1499915.0
Participants: 1
Project status: SIGNED

SYNDAM investigates how the brain detects and clears damaged proteins at the primary loci for information transfer and storage— synapses. The synapse expresses many proteins that are mutated or dysregulated in major brain disorders. The information transfer rate at synapses is high and, as a result, synapses are continuously exposed to oxidative challenges that arise from local mitochondrial respiration and oxidase activity. This puts synaptic proteins at risk. This risk is exacerbated by the long lifetimes of neuronal proteins, which prolong their exposure to environmental assaults. It is unclear how this apparent risk is mitigated by protein quality control at synapses— a vital process for brain waste clearance and synaptic homeostasis e.g. during sleep. In this context, we face a fundamental knowledge gap: we do not even know which synaptic proteins are targets of oxidative damage, let alone how such damage may trigger protein clearance via key cellular degradation signals such as ubiquitin. This elusive damage-control mechanism is critical for the restorative function of sleep. To address these knowledge gaps, SYNDAM will (1) identify the synaptic ubiquitin regulators that can detect protein oxidative damage (2) visualize the activity-dependent synaptic protein oxidative damage and ubiquitylation in situ (3) investigate sleep-regulated detection and clearance of protein oxidative damage through ubiquitin To achieve these goals, we will combine subcellular oxidized and ubiquitylated proteomics, DNA PAINT-based single-molecule localization, chemogenetic induction of synaptic oxidative damage, in situ detection of protein modifications, functional imaging, synaptic activity manipulations, electrophysiology, and sleep behaviour in mice. SYNDAM will elucidate a critical surveillance mechanism for removing damaged proteins before protein toxicity activates cellular stress responses that may lead to neuroinflammation and degeneration.

Keywords: protein quality control,ubiquitin,proteostasis,synapse
The Integrate study : An adaptive platform trial for the development of a new intervention to combat Lassa fever in Africa (INTEGRATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Germany,Nigeria,Côte d'Ivoire,France,United States,Belgium,Liberia,Guinea,Benin,Gabon
Call: Implementing adaptive platform trials (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 8800000.0
EU funding (EUR): 8000000.0
Participants: 15
Project status: SIGNED

Lassa fever (LF) is an acute febrile illness associated with bleeding, organ failure, and shock caused by Lassa virus. LF causes outbreaks in West African with in-hospital mortality up to 12%. Challenges in the clinical care of patients are multiple due to the limited availability of LF molecular diagnostics, the risk for nosocomial transmission, and the limited treatment options.There are currently no safe and effective treatment options available for LF, except ribavirin, the efficacy of which is debated. The clinical development and accessibility of effective treatment options would be a game-changer towards reducing mortality associated with this disease and limiting its socio-economic impact. Nigeria is the country by far most affected by LF in the world with about 80% of global cases. The INTEGRATE consortium builds on a more than 15 years lasting highly successful collaboration between leading European and West African institutions focusing on the joint priority to better understand, manage, and combat LF in West Africa. The overall objective of the INTEGRATE project is to establish a GCP-compliant adaptive clinical platform trial in West Africa (Nigeria and other countries) to test the efficacy, tolerability and safety of repurposed and novel drug candidates for the treatment of LF. To address this objective, we focus our activities on 3 specific objectives: - to develop and implement an adaptive randomised controlled phase II-III clinical platform trial evaluating drugs with proven preclinical activity against LF. - to build capacity for sustainable and independently conducted clinical research in West Africa by developing site, laboratory and medical care capacity through North-South and South-South technology transfer and training. This activity encompasses capacity building of the lead Nigerian institution in GCP compliant clinical trial sponsorship. - to engage communities with the proposed work plan and to assess acceptability of the trial.

Keywords: lassa fever,west africa,community engagement,adaptive platform trial,capacity building
Foundations of transcendental methods in computational nonlinear algebra (10000 DIGITS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 1393312.5
EU funding (EUR): 1393312.5
Participants: 1
Project status: SIGNED

Polynomial equations and inequalities raises fundamental theoretical issues, many of which have been answered by algebraic geometry. As of applications, nonlinearity is also a formidable computational challenge. Based on recent proof-of-concept works, I propose new foundational methods in computational nonlinear algebra, motivated by the need for reliability and applicability. The joint development of theoretical aspects, algorithms and software implementations will turn these proof-of-concepts into breakthroughs. Concretely, I will develop a theory of transcendental continuation for the numerical computation of a wide range of multiple integrals, based on a striking combination of algebraic geometry, symbolic algorithms and numerical ODE solvers. This would enable the computation of many integrals (e.g. volume of semialgebraic sets, or periods of complex varieties) with rigorous error bounds and high precision, more than thousands of digits. Building upon transcendental continuation, I propose to design algorithms to compute certain algebraic invariants of complex varieties related to algebraic cycles and Hodge classes, far beyond the current reach of symbolic methods. This surprising application is backed by a recent success on Picard group computation. Applications include algebraic geometry, with the development of computational tools to experiment on concrete examples and build databases that document the largest possible range of behavior. Besides, I propose applications to Diophantine approximations, Feynman integrals, and optimization.

Keywords: computer algebra,experimental mathematics,applications