Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Crosstalk Analysis for Microchips – a New Market Need (CRAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Helic produces Electronic Design Automation (EDA) tools, and specifically Electromagnetic Modelling (EM) software for Integrated Circuit (IC) Design. The tools are used to produce realistic models of ICs, to simulate operation under realistic conditions, thus generating savings both by reducing the number of IC prototyping and measurement cycles, as well as by significantly shortening Time to Market. The Company aims to become a world leader in a literally new market segment opening up in the EDA sector for Automated Crosstalk Analysis. The market is driven by high-value and high-growth applications in the 5G Networks, Cloud, IoT and Automotive sectors. Recent System on Chip design trends with requirements for high levels of chip density and integration, high RF frequency, Gbps bit rates and low power consumption, are establishing Crosstalk noise both as a major design constraint as well as a horrifying uncertainty for delayed Time to Market and subsequent revenue generation. Helic is in a unique position to create a game-changing Automated Crosstalk Analysis tool, which will (a) allow IC designers to abandon expensive and limiting risk-averse design practices and (b) eliminate the risk of missing the Market window of opportunity due to extended IC prototyping-debugging cycles, with potential financial penalty of up to $0.5bn for an advanced SoC. Although Helic tools contain all the necessary underlying, patented technology to tackle the problem of Crosstalk Analysis, significant product development effort is required to deliver a new Automated Crosstalk Analysis tool. The proposed feasibility study will address both the required product development effort and associated risk, as well as end-user functional requirements and market needs via an extended market survey with existing and prospect customers. The project will deliver a business plan including fully resourced product development roadmap, operational capacity and financial planning and risk assessment.

Keywords: semiconductor,integrated circuits,crosstalk noise,high frequencies
Linking genetic resources, genomes and phenotypes of Solanaceous crops (G2P-SOL)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Israel,Germany,Italy,Germany,Italy,Italy,Taiwan, Province of China,Türkiye,Bulgaria,Poland,France,Netherlands,Peru,United Kingdom
Call: Management and sustainable use of genetic resources (H2020-SFS-2015-2, 2015)
Start date: 2016-03-01
End date: 2021-12-31
Duration (months): 70.0
Total project cost (EUR): 6891265.0
EU funding (EUR): 6891265.0
Participants: 19
Project status: CLOSED

G2P-SOL is a research alliance bringing together the major European and International repositories of germplasm with public and private institutions active in genomics, phenotyping and breeding in the four major Solanaceous crops: potato, tomato, pepper and eggplant. These four crops constitute 66% of the value of European horticultural production, and over 65,000 accessions are available within the consortium. By harnessing the available global biodiversity, novel genotyping and phenotyping concepts and data analysis tools, the G2P-SOL project will link the genetic code underlying Solanaceae biodiversity with the traits that improve productivity, adaptation and human health. By making this information accessible to end-users, the awareness of the available diversity will be increased and use of this genetic diversity in breeding programs will be stimulated, resulting in diversified production chains. The phenotypes and traits of material held in European and major international collections will be described using common ontology terms developed in this project and this information will be housed in an open source software platform, allowing easy interfacing with existing platforms for germplasm cataloguing. G2P-SOL will develop shared values in science and education in the following areas: 1) Defining and maintaining genetic pools for crop improvement. 2) Phenomic and genomic data: generation, analysis, storage, and linkage with gene banks. 3) Pre-breeding and germplasm enhancement. 4) Training, workshops and public outreach. G2P-SOL will redefine how to manage and organize genetic resources and linked genomic and phenomic information in a manner that will make them accessible to naturalists, geneticists and breeders for conservation, scientific research, and breeding in the post genomic era, in compliance with the objectives of the International Treaty on Plant Genetic Resources and the Nagoya Protocol.

Keywords: solanaceae,potato,tomato,pepper,eggplant,phenotyping,genomics,metabolomics,bioinformatics,introgression breeding
The role of noradrenaline in human perception: from single neuron to whole brain and behavior (RoleOfNEinPerception)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 182509.2
EU funding (EUR): 182509.2
Participants: 1
Project status: CLOSED

How do external events become part of our subjective reality? Correlative evidence suggests that the locus coeruleus-noradrenaline (LC-NE) system might play a key role in this process: LC-NE activity is markedly reduced in sleep and anesthesia and reinstated upon recovery of conscious perception, while during wakefulness it correlates with markers of conscious perception. However causal evidence, as well as sensitive experimental paradigms that carefully manipulate awareness in this context, are absent. This proposal aims at providing this missing causal link by pharmacologically manipulating NE levels bi-directionally in healthy volunteers performing liminal visual and auditory perceptual tasks, while reporting their subjective perceptual state. Neural signals will be recorded using simultaneous EEG-fMRI allowing high spatio-temporal resolution. If indeed NE plays a causal role in enabling conscious perception then reduced NE activity will increase perceptual threshold and give rise to impoverished neural responses, whereas enhanced NE activity will aid perceptual incorporation and effectively drive neuronal activity in high-order cortical regions. In a complementary set of experiments I will use a rare opportunity to record single-neuron and LFP activity from neurosurgical patients performing the same perceptual tasks while using pupillometry as a proxy for momentary NE levels. The exceptional signal-to-noise ratio of these recordings will allow linking precisely localized neuronal activity, momentary NE levels, and perception on a trial-by-trial basis, thereby refining and extending the EEG-fMRI results. The ability to manipulate and measure NE levels in subjects reporting their subjective state in sensitive perceptual paradigms, together with comprehensively examining neuronal activity from the level of individual neurons to the whole brain, promise to yield unique results that will shed new light on the neurobiological underpinnings of conscious perception.

Keywords: noradrenaline,norepinephrine,sleep,conscious perception,sensory disconnection,visual awareness,auditory awareness,pharmacology,fmri,intracranial recordings
Public Procurement of Innovative Solutions for High-Performance Computing (PPI4HPC)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Public Procurement of Innovative Solutions
Countries involved: Spain,Italy,Germany,France
Call: Platform-driven e-infrastructure innovation (H2020-EINFRA-2016-2, 2016)
Start date: 2017-04-01
End date: 2021-09-30
Duration (months): 54.0
Total project cost (EUR): 74193295.0
EU funding (EUR): 25967653.25
Participants: 5
Project status: CLOSED

In its communication on the “European Cloud Initiative” the European Commission in April 2016 stressed the need for building an European Data Infrastructure including high-end supercomputers, which will around 2022 reach the exascale performance level. In this proposal, a group of leading European supercomputing centres propose the formation of a buyers group to execute a joint Public Procurement of Innovative Solutions (PPI) in the area of high-performance computing (HPC). The co-funding by the European Commission (EC) will allow for a significant enhancement of the planned pre-exascale HPC infrastructure from 2018 on. The total investment is planned to be about € 73 million. The involved HPC centres, namely BSC, CEA/GENCI, CINECA and JUELICH, have a strong track record in providing supercomputing resources at European level. The project participants are founding members of PRACE and have made Tier-0 systems available through PRACE. This joint initiative will create benefits in multiple respects: ▪ More supercomputing resources will be efficiently exploitable for science and engineering applications in Europe within PRACE, the pan-European HPC infrastructure, as selected, relevant applications will play an important role in guiding this procurement process. ▪ R&D on HPC architectures and technologies in Europe will be strengthened as suitable incentives will be provided by this joint procurement process. ▪ The coordinated approach will give us a greater weight and allow having more impact on the design of the solutions according to the need of scientists and engineers in Europe. The participants will work together on coordinated roadmaps for providing HPC resources optimised to the needs of European scientists and engineers. The final decision on which innovative solutions will be procured at the different sites will be made following these roadmaps, but remain a decision of the individual sites.

Keywords: high performance computing,exascale computing
Pancreatic islet dysfunction and type 2 diabetes – beyond the genome (PAINTBOX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2023-04-30
Duration (months): 67.0
Total project cost (EUR): 1969445.0
EU funding (EUR): 1969445.0
Participants: 1
Project status: SIGNED

The prevalence of type 2 diabetes (T2D) is rapidly increasing worldwide and despite great efforts to prevent and cure the disease, the increase persist. There is an urgent need to develop innovative and effective prevention and treatment strategies for T2D. Recent genome-wide association studies were expected to uncover disease-causing mechanisms in common metabolic disorders. Surprisingly, the identified genetic variants only explain a small proportion of the estimated heritability of T2D. Novel studies, going beyond the genome, are therefore needed to identify key mechanisms causing T2D. These studies should focus on pancreatic islets, the tissue of primary pathogenetic importance for diabetes. Also, mechanisms that allow environmental factors to come into play are likely to be important. Epigenetics fulfill such criteria, and our previous work has pioneered epigenetic discoveries in T2D. PAINTBOX is a multidisciplinary research program through which I will combine advanced sequencing technologies and novel epigenetic methods with mathematical models and clinical medicine to develop new prediction and treatment strategies for T2D. Innovative techniques and access to some of the world´s best patient cohorts permit me to address the role of epigenetics in development of T2D in new ways. The annotation of these discoveries will be done using genome-wide epigenomic and targeted gene-editing tools together with mathematics, whereas the translation of those findings will be achieved using powerful prospective cohorts for T2D and clinical studies. PAINTBOX capitalizes on the largest existing human islet cohort and large prospective cohorts, and expertise that I have built-up over the past twenty years, but also exploits novel epi-genomic and gene-editing technologies that have not previously been used for T2D. I expect this novel interdisciplinary project to generate groundbreaking results that opens up new horizons for prediction, prevention and treatment of T2D.

Keywords: endocrinology,type 2 diabetes,pancreatic islets,insulin secretion,dna methylation,histone modifications,non coding rna,biomarkers,prediction,epigenetic editing,treatment,hdac inhibitors
A real-time slope stability and subsidence monitoring service to improve productivity and to prevent catastrophic events in the mining industry (MOTIONMAPPER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-10-01
End date: 2021-09-30
Duration (months): 36.0
Total project cost (EUR): 2065750.0
EU funding (EUR): 1428700.0
Participants: 1
Project status: CLOSED

The mining industry is growing and is a key global economic driver, providing raw materials for consumer and industrial products, being Europe one of the most demanding regions of raw materials. Mining operations relie on large scale, continuing, and safe operations in and around geological sites, but with repeated accidents and non-complete monitoring of how operations are impacting the terrain, the issue is far from resolved. Disasters occur, such as collapses of mining slopes, or ‘tailings dams’ with a release of chemicals leading to loss of life, interruption of mining operations and catastrophic environmental consequences: a collapse of a tailings dam may destroy natural drinking water and rivers for centuries. DARES, a European company formed by staff with multiple years’ of experience in the industrial remote monitoring field wish to change this. We have been developing and commercializing an industry leading satellite-based remote monitoring solution. Now we are adding Drone, Ground Radar and near-realtime processing to generate a complete wide area to local area monitoring and alerting solution. Called MOTIONMAPPER 2.0, it represents a ground-breaking solution to ensure safety of operations and to guarantee operational efficiency. We are in a unique position to do this. We have both the academic and industrial skill sets, as well as monitoring contracts with several large mines operating our satellite-based solution. Following a successful phase 1 feasibility study, we propose a two-year project to fund the complex technical work and commercial entry preparations. Generating a new product category in a sector with clear demand, we predict sales of 22M€ by 2022, growth to 55 employees and a substantial impact on the protection of the environment as well as the European Earth Monitoring sector and its technical expertise.

Keywords: radar,interferometric synthetic aperture radar insar,earth observation,remote sensing,copernicus,land surveying,land mapping,disasters risk reduction,subsidence
In vivo Directed Evolution As a Service for the development of novel microorganisms leveraging the full potential of White Biotechnology. (IDEAS)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: France
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 2889750.0
EU funding (EUR): 2022825.0
Participants: 1
Project status: CLOSED

Today’s exploitation of nature is no longer sustainable. New sustainable industrial processes must urgently be implemented. White Biotechnology, also known as Industrial Biotechnology, has potential to build a greener future by replacing fossil-based processes for the production of our essential needs. This field uses living microorganisms such as yeast, bacteria and microalgae to generate sustainable industrial products and processes. However, despite significant advancements in genome editing tools, metabolic engineering and data exploitation, these techniques fail in developing microorganisms fulfilling demanding industrial requirements for the production of a wide array of products. For this reason, the potential of White Biotechnology still has to be achieved. Altar is a French Deep Tech founded in 2017 which develops a disruptive platform harnessing the power of natural selection for the development of novel microorganisms fulfilling specific industrial needs. Our innovation induces in vivo directed evolution or adaptative evolution of microorganisms in order to adapt them to the harsh conditions of industrial processes. Altar’s Evolution Platform is based on proprietary technology and culture protocols controlled by novel algorithms. Moreover, its operation is completely automated and digitalized. Altar has built an enthusiastic and skilled team of 8 women and men with combined experience in business, biotechnology, software, engineering, fluidics and microbiology. The EIC Accelerator project aims to finalize the Evolution Platform’s development and commercialize it globally. We gathered 19 letters of interest highlighting interest from various international stakeholders. Our ambition for the next decade is to become a global leader in the development of microorganisms for White Biotechnology and therefore pave the way towards a sustainable and green European future.

Keywords: white biotechnology,industrial biotechnology,industrial microbial hosts,sustainable industry and goods,in vivo directed evolution,adaptive laboratory evolution,natural selection,digitalization
A probabilistic framework for assessing polar wander – Constraining paleolongitude in deep time (TANGO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2024-05-21
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: SIGNED

The quantification of past plate motions is of paramount importance to advancing our understanding of Earth’s evolution. Plate motions of the last ~130 Ma are well-resolved from magnetic isochrons and hotspot tracks, but as those records are progressively destroyed by subduction, they cannot be used in deeper time. Before 130 Ma, plate motions can only be quantified through the study of paleomagnetism, but analytical limitations have so-far prevented us from using this tool to its full potential. For example, owing to the axial symmetry of the Earth’s magnetic field, the determination of paleolongitude from paleomagnetic data –although theoretically possible– has long been considered an intractable problem. TANGO will capitalize on this untapped potential through an innovative and cross-disciplinary approach integrating modern data-science techniques into paleomagnetic research, thereby opening a new research frontier. Aiming to contribute towards the neglected issue of paleomagnetic precision, I will focus on state-of-the-art computer-intensive statistical methods to provide the conceptual basis for a much needed probabilistic framework for paleomagnetic research. These efforts will allow me to provide paleogeographic reconstructions with uncertainty estimates for the first time. With that framework, through application of unsupervised learning methods, I will also be able to tackle the outstanding problem of paleolongitude determination in deep geologic time, which remains one of the most important challenges in modern geophysics. Such novel and quantitative methods development is strongly complementary to the core research efforts at CEED (University of Oslo) to explore the missing links between plate tectonics and mantle evolution. In this pursuit, TANGO will reinforce the international and multidisciplinary dimension of my early stage career and will allow the European Union to remain at the cutting-edge of paleomagnetic and tectonic-related research.

Keywords: paleomagnetism,tectonics,paleogeography,plate kinematics,polar wander,geostatistics,uncertainty quantification,data science
Deciphering the mechanism of the dual functional E3 ligase TRIM28 in cancer cells (TRIM MAGE complexes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

TRIM family proteins are RING-type E3 ubiquitin ligases with important roles in immune responses, autophagy and cellular signalling. They are characterised by the presence of an N-terminal tripartite motif that harbours the catalytic RING domain and a C-terminal variable substrate-binding domain. TRIM28/KAP1 is a unique family member that is better known for its role in transcriptional repression, which is mediated via its C-terminal PHD-Bromo domains. Nevertheless, ubiquitination activity has been described for TRIM28, especially in cancer cells, in conjunction with Melanoma Antigen (MAGE) proteins. MAGE proteins are aberrantly expressed in many cancer types and have been proposed to regulate and activate TRIM28 E3 activity to mediate proteasomal degradation of prominent targets, including p53 and AMPK. Cellular and molecular details of TRIM28 MAGE-dependent ligase activity remain unknown. Furthermore, it is unclear, how the interplay between the two functions of TRIM28 is regulated and how the protein E3 ligase activity is supressed when recruited as part of transcriptional silencing complexes. I want to use a multi-disciplinary approach and combine unbiased proteomic studies with in vitro biochemical, biophysical and structural experiments to study MAGE-dependent regulation of TRIM28 E3 ligase activity. I aim to identify cellular signals such as posttranslational modifications and interaction partners that can both modulate MAGE-TRIM28 complexes and regulate the interplay between the transcriptional and the E3 ligase activity. By combining these findings with structural and mechanistic studies, I will uncover how MAGE proteins modulate substrate recognition, E2 recruitment and ligase activity of TRIM28, and create a model of MAGE-TRIM28 function.

Keywords: ubiquitination,e3 ligases,trim family proteins,structural biology,cell signalling