Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
eHealth Standards and Profiles in Action for Europe and Beyond (eStandards)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Coordination and support actions
Countries involved: Italy,Germany,Belgium,Belgium,France,Netherlands,Netherlands,Portugal,Denmark
Call: eHealth interoperability (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-05-01
End date: 2017-07-31
Duration (months): 27.0
Total project cost (EUR): 999769.0
EU funding (EUR): 999769.0
Participants: 13
Project status: CLOSED

The eStandards CSA is proposed by HL7, CEN TC251, & IHE, leading Standards Organizations (SDOs), and is supported by the eHealth Network, ISO TC215, GS1, IHTSDO, IEEE11073, and IMIA to advance eHealth interoperability and global alignment of standards with seven objectives: 1. Join up with Stakeholders in Europe and globally to build consensus on eHealth standards, accelerate knowledge-sharing, and promote wide adoption of standards. 2. Deliver an evidence-based Roadmap for alignment, iterative consolidation, and broad acceptance of eStandards that is endorsed by SDOs, the eHealth Network, the providers, and the Industry. 3. Contribute to the eHealth Interoperability Framework use cases focusing on clinical content modelling for different paradigms and embed a Quality Management System for interoperability testing & certification of eHealth systems. 4. Collect evidence and provide guidance on the coexistence of competing or overlapping standards in large-scale eHealth deployment nationally and cross-border. 5. Participate in EU/US MoU roadmap actions as the international patient summaries standard. 6. Explore socio-economic aspects of eHealth interoperability, revisiting the language for user-vendor interaction that embodies ‘co-making’ in trust, collaboration and long-term engagement. 7. Align across PHC-34 to nurture innovation, sustainability & growth under CEF and beyond contributing to Key actions of the Digital Agenda 2020. The proposal’s ambition is to strengthen Europe’s voice and impact, while reinforcing the bridges established with the EU Patient Summary guideline across the Atlantic in Trillium Bridge and among MS with epSOS, eSENS, Antilope, and EXPAND. The eStandards Roadmap and associated evidence base, a white paper on the need for formal standards, and two guidelines addressing how to work with: (a) clinical content in profiles and (b) competing standards in large-scale eHealth deployments will be pragmatic steps toward alignment and convergence.

Keywords: standards,interoperability,clinical models
hSpindly, a new regulatory protein of the SAC mechanism and its implication in tumour therapy (SpinSAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2025-02-16
Duration (months): 36.0
Total project cost (EUR): 259398.72
EU funding (EUR): 259398.72
Participants: 1
Project status: SIGNED

During mitosis a sophisticated surveillance system, known as the spindle assembly checkpoint (SAC), is crucial to make sure that the cell does not separate its sister chromatids until all the chromosomes are correctly attached to spindle microtubules and bi-oriented. Nowadays, one of the more important strategy used for the cancer treatment is the inhibition of the microtubule dynamic to activate the SAC by the addition of anti-mitotic drugs. At the end, the activation of SAC for a long period provokes the cell death, compromising the tumour cell proliferation. Nonetheless, there are tumour cells, which are affected in SAC activity showing a reduction in the efficiency of this treatment. For this reason, it is becoming extremely useful to seek new proteins which are implicated directly to SAC functionality. This project will be focused on the study of hSpindly as a new protein implicated in SAC regulation independently of the stripping pathway. hSpindly has a role in the SAC mechanism but how it works is absolutely unknown. hSpindly is highly phosphorylated in mitosis so, finding the residues which are phosphorylated in this cell cycle phase, will allow us to know not only the role of these phosphorylations in SAC but also its implication in the cell response in the presence of antimitotic drugs. For this, we will use several approaches and state of the art techniques as confocal microscopy and the CRISPR/Cas9 nickase system. This study will contribute with relevant results in basic and clinical research. The knowledge of the hSpindly function might reveal new therapeutic targets for the treatment of the tumours more resistant to anti-mitotic drugs. Additionally, it would be possible to get phosphospecific antibodies of key residues in the hSpindly function, which could be used as tumour marker in the future.

Keywords: mitosis,chromosome segregation,checkpoint,cancer
Endothelial Cell Signature in the Total Environment (ECSiTe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-08-22
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: TERMINATED

Endothelial cells (ECs) specialize towards tissue-specific needs by shaping their phenotypes in response to microenvironmental stimuli, becoming a highly heterogeneous population. Overlooking the EC heterogenic nature most likely underlies the low efficacy and side-effects of broad-spectrum treatments for vascular bed-specific diseases. However, little is known on the interplay between the factors regulating the EC signatures, and tissue engineering research has essentially used standard and poorly differentiated ECs. The objective of this proposal is to investigate the mechanisms by which tissue-specific mechanical, biochemical and genetic factors interact to regulate EC signatures. To do so, brain and aortic valve ECs –non-standard and highly specialized EC types– will be used. First, by using custom-made hydrogels and a flow chamber device, a combination of different levels of tissue stiffness and shear stress will be applied to ECs in culture. The impact and interaction of both mechanical forces on EC features will be determined by analysing changes in EC phenotypes and in gene expression profiles. Then, brain and valve-specific mechanical forces will be selected, and brain and valve ECs will be cultured under organ-matching mechanical forces but under organ-switched biochemical factors. Because these ECs have strong signatures, by analysing phenotypical shifts, the impact of tissue-specific biochemical factors on EC signatures will be determined. Finally, the genetic impact on brain and valve EC phenotypes and the capability of modulating these through microenvironmental design will be studied by analysing phenotypical shifts after culturing brain and valve ECs under organ-switched total (mechanical and biochemical) environments. In a nutshell, this proposal will provide new knowledge in how specialized ECs integrate the different factors regulating their heterogeneity, leading to new future perspectives on tissue-specific vascular bed repair strategies.

Keywords: endothelial cell,shear stress,tissue stiffness,mechanotransduction,differential gene expression,heterogeneity regulation,blood brain barrier endothelial cell,valve endothelial cell
Conductive suspension flows for soft electronics (ELECTROFLUID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: SIGNED

Today, most electronics and robots are based on solid metals and semiconductors. This project aims at “Electrofluids” that conduct electrons while flowing as liquids. Because liquids have virtually no yield strength, they are ideal materials to replace solid metal leads in truly soft devices. ELECTROFLUID uses highly concentrated suspensions that are liquid in a wide temperature range. Transient conductive networks in suspended particles of commonly used conductors provide high level of electronic conductivity at the viscosities required for soft electronics and robots. They contain common conductive materials such as carbon, silver, gold, and copper and do not require specialized low-melting alloys of gallium or other expensive elements. In order to create stable Electrofluids with large conductivity at low viscosity with tuneable rheology, I study the interplay between particle-particle friction, contact resistance, percolation, bulk resistance, and suspension viscosity. I use both custom-synthesized and commercial particles in a size range of tens of nanometres to few microns and with different shapes, modify their surfaces with conventional and pi-conjugated surfactants, and formulate concentrated suspensions that exhibit large conductivity at low viscosity. The combination of different particle sizes, shapes, and fluids enables tuning the properties of the fluid towards specific application cases, for example to create highly flexible leads for logic signals versus high-power connections for the connection of actuators. The fluids will be encapsulated in elastomer tubes or micropatterned surfaces as they are commonly used in stretchable electronics. The specific aims of the project are: (i) to design highly concentrated suspensions that form transient percolating networks, (ii) to use this knowledge and synthesize fluids with tuneable electrical conductivity at low viscosity, (iii) to demonstrate that Electrofluids can be curtailed for particular applications.

Keywords: electronically conductive liquids,highly concentrated suspensions,soft electronics,conductive particles,transient conductive networks,complex fluids,percolation
SMEntorEGE (SMEntorEGE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Türkiye,Türkiye
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 95520.0
EU funding (EUR): 94388.0
Participants: 3
Project status: CLOSED

The objective of SMEntorEGE is to support the regional SMEs to enhance their innovation management skills by improving efficiency and effectiveness of innovation processes, thus contributing to smart growth. Two groups of SMEs are targeted for the services that will be given under the project. The first group involves the SMEs who are the beneficiaries of “Horizon2020's SME instrument” or other EU Funded Schemes such as FP7, EUREKA, EUROSTAR, but who need technical support in innovation management to enhance successful exploitation of the project and its contribution to the companies’ growth. The second group consists of SMEs with potential for international growth via product/process/service/business model innovation but who lack the knowledge, skills to manage innovation activities. Two different services will be provided throughout the project period. “Key account management” for the beneficiaries of the SME instrument will focus on identifying bottlenecks to the creation of economic impact in companies benefitting from EU grants and address these bottlenecks with the help of capable Coaches and with the aid of KAM services of EEN. “Enhancing SME innovation management capacity” for innovating SME independently from a specific project will focus on increasing the efficiency and effectiveness of innovation processes in SMEs with significant innovation activities that could potentially become beneficiaries of European research and innovation supports, but not have effective access to consulting services for innovation management. As a result of the project, new types of standardised innovation support methodologies will be developed, the skills of the staff from the existing consortia will be improved, comprehensive innovation support will be given, EEN will be embedded in Regional Innovation Ecosystem, closer cooperation will be established between key innovation support providers and relevant stakeholders.

Keywords: innovation management capacity,smes,mentoring,coaching,key account management
SAFEguard of Critical heAlth infrastructure (SAFECARE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Protect and improve the resilience of critical infrastructures, supply chains and tranport modes
Action type: Innovation actions
Countries involved: Germany,Italy,Belgium,Poland,Greece,Belgium,Romania,France,France,France,France,Netherlands,Netherlands,Portugal,Denmark
Call: Prevention, detection, response and mitigation of the combination of physical and cyber threats to the critical infrastructure of Europe. (CIP-2016-2017-2, 2017)
Start date: 2018-09-01
End date: 2021-11-30
Duration (months): 39.0
Total project cost (EUR): 9573979.63
EU funding (EUR): 7994553.63
Participants: 22
Project status: CLOSED

Over the last decade the European Union has faced numerous threats that quickly increased in their magnitude, changing the lives, the habits and the fears of hundreds of millions of citizens. The sources of these threats have been heterogeneous, as well as weapons to impact the population. As Europeans, we know now that we must increase our awareness against these attacks that can strike the places we rely upon the most and destabilize our institutions remotely. Today, the lines between physical and cyber worlds are increasingly blurred. Nearly everything is connected to the Internet and if not, physical intrusion might rub out the barriers. Threats cannot be analysed solely as physical or cyber, and therefore it is critical to develop an integrated approach in order to fight against such combination of threats. Health services are at the same time among the most critical infrastructures and the most vulnerable ones. They are widely relying on information systems to optimize organization and costs, whereas ethics and privacy constraints severely restrict security controls and thus increase vulnerability. The aim of this proposal is to provide solutions that will improve physical and cyber security in a seamless and cost-effective way. It will promote new technologies and novel approaches to enhance threat prevention, threat detection, incident response and mitigation of impacts. The project will also participate in increasing the compliance between security tools and European regulations about ethics and privacy for health services. Finally, project pilots will take place in the hospitals of Marseille, Turin and Amsterdam, involving security and health practitioners, in order to simulate attack scenarios in near-real conditions. These pilot sites will serve as reference examples to disseminate the results and find customers across Europe.

Keywords: global protection system,prevention,detection,response,mitigation,infrastructures
Polymeric cyclodextrin-based nanoparticles for combination therapy of castrate-resistant prostate cancer (POLAR STAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Prostate cancer (PC) is the fifth leading cause of cancer-related death worldwide. PC often presents in its Multidrug resistant form leaving the patient few survival chances. New approaches are required to overcome resistance-related problems in PC and nanomedicine holds a lot of premises to effectively contribute in this battle. In this frame POLAR STAR aims at the implementation of combination therapy to treat castrate-resistant PC. Our strategy is to exploit innovative nanotechnology to administer contemporarily different therapeutic agents that synergically exert their activity across multiple oncogenic pathways. We plan to use new mixed polymers based on biocompatible cyclodextrins as these building blocks are already FDA approved. Simple organic chemistry is pursued to implement target selectivity and in vivo tracking of the polymeric nanocarrier. The design is guided by the final goal, the future clinical application of nanocarriers to improve PC treatment, keeping in mind upgrade of the nanocarrier systems to large scale production. We will focus on the latest PC drugs suffering from side effects and emerging resistance as multiple cargo to be loaded. Full chemico-physical characterization of the systems is planned as well as assessment of the efficacy of loaded nanocarriers in cell cultures with different drug responsivity profiles. In order to reduce animal experiments POLAR STAR will take full advantage of 3D prostate tissue models for biological tests, an apporach at the forefront in drug design. We plan to reach our goal bringing together the expertise of the fellow and the supervisor supported by the private and academic teams hosting the fellow during secondments. POLAR STAR creates a multidisciplinary environment where all actors, public and private, will benefit from reciprocal transfer of knowledge. During the project the fellow will have the possibility to become a complete researcher improving also complementary skills.

Keywords: 3d prostate cancer model,multi drug resistance
A subcortical BCI to restore skilled movement (SubcorticalBCI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Every year, half a million people become paralysed by a spinal cord injury. Assistive technologies, such as Brain-Computer Interfaces (BCIs), can improve their mobility, independence, and overall well-being. BCIs bypass a neurological injury by reading the user’s intent from their brain activity and using it to control a computer cursor or a robotic arm, or even to reanimate their own paralysed limbs. Despite these remarkable feats, BCIs still face challenges that prevent their widespread use. Here, I propose to address two of their main shortcomings: their unintuitive control that produces unskilled movements, and their instable performance that decays over time. The brain controls movement by coordinating the activity of many areas. Thus, unintuitive BCI control might be due to their reliance on the activity of a single cortical region (typically motor cortex) to decode the user’s intent. I will develop a new type of BCI that reads the activity of the striatum, a subcortical area that receives inputs from the entire cortex and has been shown to be critical for skilled movements. My hypothesis is that a BCI based on striatal activity will mimic the execution of a skilled movement. Using large-scale neural recording techniques and emerging computational techniques, I will identify striatal population dynamics and use them as input for the BCI, expecting to show that such an approach outperforms current BCIs. Next, I will address the instability problem. BCI instability is mainly caused by the inevitable changes in recorded neurons over long timescales. My host has recently developed a method that reveals the ‘true’ cortical dynamics underlying a given behaviour. I will adopt this method for the proposed BCI to stabilise its performance over long time periods. If successful, this project will lead to BCIs that are easier to use, more precise, and stable. Their future translation to humans could bring BCIs closer to the clinic, with considerable socioeconomic impact.

Keywords: brain computer interfaces,brain machine interfaces,neuroprosthetics,neural engineering,electrophysiological recording,motor control,neural data science
Low temperature heat / solar driven air conditioning system for heating, cooling, dehumidification and ventilation of buildings (freescoo)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-09-01
End date: 2016-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Freescoo is the first plug and play, economically viable mass product for small scale (residential and small tertiary) heat/solar driven air conditioning system providing: heating, cooling, dehumidification and ventilation in a single unit. It is based on patented heat driven Desiccant Evaporative Cooling (DEC) open cycle, working with low temperature heat (55°C). This makes it possible to install the product in substitution of existing radiators / fan coils using the existing heat distribution network as heat source. Freescoo is the highest performing heat driven cooling solution (100% more efficient) and has Energy Efficient Ratio of 13 against max 8 of electricity driven solutions. It is 60% cheaper compared to Exhaust Air Heat Pump (EAHP), the only alternative solutions providing complete air conditioning solution in one device. The target product is freescoo 2.5 kW cooling – 4,5 kW heating power unit, for a price of 3.600 Euro, margin of 45%. The market addressed is the substitution of 2 existing market solutions: EAHP mainly applied in passive and nearly zero energy consumption buildings; reversible and high efficient split units (room air conditioning), providing the add on ventilation. Preliminary market plan foresees 3.500 units sold after 5 years, with turnover of 12 M€, cumulated profits of about 8.7 M€, Internal Rate of Return of 41%. The manufacturing will be realized in agreement with a company involved in manufacturing of air conditioning plants and distribution in collaboration with manufacturers of solar thermal components, both already identified. The technology was validated in relevant environment and recognized as one of the most promising heat driven cooling solutions by the expert group on Solar Heating and Cooling (SHC) Programme of the International Energy Agency (IEA). Objective of SME Instrument is to support product engineering, optimization of manufacturing, validation of the technology, definition of the commercial agreements.

Keywords: open cycle dec,heat driven cooling,solar cooling,building integrated,heat recovery ventilation