Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unleashing the curative potential of cancer immunotherapy (UNLEASHAD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-07-01
End date: 2021-12-31
Duration (months): 42.0
Total project cost (EUR): 2528750.0
EU funding (EUR): 1770125.0
Participants: 1
Project status: CLOSED

TILT Biotherapeutics is developing a breakthrough oncolytic immunotherapy for treatment for cancer. Advanced solid tumors are currently incurable and limited treatment options are available – preclinical data on TILT technology suggests curative potential. There are over 9 million people dying from cancer each year and the incidence is growing rapidly. New immunotherapies for cancer are more widely available in America than in Europe partly because clinical research concentration in the U.S. Cancer patients also in Europe are in the increasing need of new treatment options. The objective of this project is to generate a clinical proof-of-concept for the company’s lead product, TILT-123 alone and given with anti-PD(L)1 therapy in metastatic melanoma and other advanced solid tumors by completing Phase I clinical development. This project will last in total about 3,5 years and allow the company to confirm safety in human for TILT-123 as well as to generate mechanism of action data. Eventually, this could result in improved treatment responses in currently incurable anti-PD(L)1 refractory patients with melanoma and other solid tumor types. TILT-123 is now entering clinical stage with all the key proof-of-concept and safety already demonstrated. Pilot and GMP-grade product production is completed and authorization for the first-in-man clinical trial in Denmark was obtained. EU support continues to be critical to launch this project onto clinical path. Actors from at least five different European countries are involved, underlining project’s EU-wide relevance. From the business perspective, this project would allow the company to mature into a stage from where its further development could be privately funded and supported by a pharmaceutical company. TILT Biotherapeutics will invest into further development of its pipeline projects, create more employment and business locally in Finland and Europe, and to bring an innovative treatment option with curative potential to the reach of European cancer patients.

Keywords: oncolytic virus,solid tumor,t cell therapy,anti pd 1 antibody,checkpoint inhibitor,phase i clinical trial
Normalizing a Difficult Past? Cultural trauma and collective memory in Austria and Croatia (CULTRAMACY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-01
End date: 2022-09-29
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Following the theoretical framework of cultural trauma, this project's aim is to analyze the impact of trauma on collective memory of wars in Austria and Croatia, as well as the social processes through which such memory is produced, performed and maintained. More specifically, a dynamics of two corresponding forces are explained: cultural trauma representing a response to a tear in social fabric and collective memory acting as a cohesive element for group identity. The CULTRAMACY project draws on methods of both quantitative and qualitative analysis and uses the methodological tool of frame analysis. In order to analyze the impact of trauma on collective memories, this comparative study addresses the following specific objectives: 1) repercussions of trauma on collective and individual, as well as cultural and public memories, 2) traveling of memory through time and space - generational and transcultural transmission of memory, 3) analysis of patterns of European memory. This research is situated on the intercept of the scientific fields of memory studies, social theory and political science. It aims to contribute to academic research on three different levels. First, it contributes to the theoretical debates in memory studies by approaching collective memory from the perspective of cultural trauma. Second, it offers a truly comparative perspective outside of the methodological regionalism, while still acknowledging the nation as one important framework or "scale" of collective remembrance. Finally, this research tracks the travels of memory across borders and generations in order to give some innovative insights for similar phenomena in ever-more globalised world experiencing migration flows. Hence, the CULTRAMACY project aims to map a critical engagement with negative heritage, cross boundaries of national memories and verify the basis of the transcultural sphere of European memory.

Keywords: cultural trauma,transcultural memory,collective identity,central and southeastern europe
Stepping up and bringing out the scientific excellence and innovation capacity in soil research of the University of Lisbon (SOILdarity)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Israel,Belgium,Belgium,Portugal
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 899976.25
EU funding (EUR): 899976.25
Participants: 5
Project status: SIGNED

SOILdarity is a three-year project aiming to enhance scientific excellence in soil science. The project fosters the cooperation between two internationally leading research-intensive institutions and FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (FC.ID). FC.ID is a private non-profit association endowed with legal personality whose aim is to support and develop research and innovation activities of the Faculty of Sciences of the University of Lisbon (CIÊNCIAS). CIÊNCIAS is a key research centre in soil science in Portugal. Within the framework of the Twinning exercise the beneficiary is FC.ID while CIÊNCIAS will be a linked third party to FC.ID. Soil ecosystems in Portugal face considerable challenges in the medium and long run ranging from climate change and erosion to over exploitation dynamics. By developing SOILdarity, FC.ID and CIÊNCIAS aims at boosting its research and innovation capacity and improving its know-how in precision agriculture and sustainable soil management through the knowledge-transfer dynamics established with the internationally leading research-intensive partners, i.e. MIGAL and the University of Ghent. The project lays down a sound scientific strategy on how to integrate soil ecology with cutting-edge soil and crop sensors, modelling and system control technology for sustainable soil management. The project methodology intervenes on four complementary levels: a) transfer of knowledge to FC.ID/CIÊNCIAS on key research challenges; b) reinforcing FC.ID and CIÊNCIAS’ positioning in the EU research arena, seeking new alliances with top R&I organisations; c) skill and capacity building for a new generation of young researchers, who will constitute the main capital of the Portuguese University in the years to come; and d) develop a stable framework dedicated to international cooperation and knowledge transfer.

Keywords: soil science research,precision agriculture technologies,water management,sustainable development goals,scientific and technology capacity,international cooperation for research and innovation
LEAPS pilot to foster open innovation for accelerator-based light sources in Europe (LEAPS-INNOV)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Innovation and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Germany,Germany,Italy,Italy,Germany,Poland,Sweden,Sweden,Switzerland,France,France,France,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Innovation pilots (H2020-INFRAINNOV-2020-2, 2020)
Start date: 2021-04-01
End date: 2025-03-31
Duration (months): 48.0
Total project cost (EUR): 10000000.0
EU funding (EUR): 9999991.28
Participants: 24
Project status: SIGNED

The European synchrotron radiation sources and free electron lasers serve a broad scientific community with more than 24000 users and play a vital role in most research fields from basic science in physics, chemistry and biology to applied areas in health, engineering, environment, cultural heritage and high-impact industrial applications. Rising international competition requires the European facilities to coordinate and combine complementary strengths and capabilities. Established in 2017, the League of European Accelerator-Based Photon Sources (LEAPS) seeks to realise synergies across Europe’s light sources. The increasing complexity of technology and a shorter life cycle require the photon sources to open up innovation to their partner facilities, users and industrial suppliers to promote creativity, novelty and resource efficiency. The LEAPS-INNOV pilot project will contribute to solving key technological challenges for the light sources, over 50 facilities in Europe and worldwide, and in particular will support their newest generation - diffraction-limited storage rings and X-ray FELs. It will kick-start the implementation of the LEAPS Technology Roadmap and, at the same time, will enhance partnership with industry through open innovation by offering joint technological developments and advanced research capabilities for industry as collaborators, suppliers and users. Six technology work packages (WP) form the heart of LEAPS-INNOV, based on their potential for co-innovation and their ability to enhance European leadership of both, LEAPS facilities and industry. They integrate 50-some companies, are supported by an industry networking WP and complemented by pilot activities towards co-creation with the Horizon Europe clusters. In the context of open innovation, LEAPS-INNOV focusses on new approaches for partnership between industry and the photon science community, with the goal of accumulating a strategy for long-term industry engagement for LEAPS in Europe

Keywords: research infrastructures,accelerator based light sources,synchrotron,free electron laser,leaps,open innovation,pilot action,industry,co creation,technology transfer,knowledge transfer
Smart protonic quantum frequency circuits (QFreC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1497658.0
EU funding (EUR): 1497658.0
Participants: 1
Project status: SIGNED

Machine learning empowers computers to solve complex tasks such as pattern identification and strategy optimization with applications in, e.g., financial trading, fraud detection, medical diagnosis, and self-driving vehicles. The required computing power is, however, pushing existing computational resources to their limits, restraining their further advancement. In QFreC, I target the realization of photonic frequency-based quantum co-processors, specifically tailor-made to solve machine learning problems with capabilities commensurate with today’s high-power, yet energy-efficient processing needs. In particular, I will use a high-dimensional photonic quantum frequency comb approach, where photons have hundreds to thousands of discrete and equidistantly spaced frequency modes, giving access to large, scalable information capacity. For implementing quantum-accelerated machine learning tasks such as the classification of classical or quantum data, I will follow i) the exploration of quantum photonic frequency-domain processing with the adaptation of qubit learning concepts (vector-based and neural network-based approaches) to high-dimensional quantum representations, i.e., quDits, ii) the realization of efficiency-enhanced and novel integrated quantum frequency comb systems with quantum resources that allow real-world applications using highly nonlinear on-chip platforms, and iii) the development of reconfigurable, fast, and broadband experimental control schemes using, e.g., quadrature amplitude modulation formats and nonlinear optical processes. To enable stable, compact, cost- and energy-efficient quantum processing devices, the QFreC project will build on the advances of the well-developed telecommunications infrastructure and the photonic chip fabrication industry. QFreC merges photonic quantum frequency-domain circuits with quantum machine learning, enabling large-scale controllable quantum resources for the exploration of quantum-enhanced machine learning

Keywords: integrated quantum optics,on chip frequency combs,machine learning,photonic quantum signal processing
Empowering local renewable energy communities for the decarbonisation of the energy systems (LocalRES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Austria,Germany,Ireland,Italy,Italy,Austria,Spain,Italy,Austria,Spain,Italy,Spain,Italy,Spain,Belgium,Finland,Finland,Belgium,France,France,France
Call: Integrated local energy systems (Energy islands) (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2021-05-01
End date: 2025-04-30
Duration (months): 48.0
Total project cost (EUR): 7194071.43
EU funding (EUR): 6095862.5
Participants: 23
Project status: SIGNED

LocalRES project will deploy innovative local energy systems driven by renewable energy communities for a socially fair energy transformation that puts renewable energy into the hands of communities and people. LocalRES will deliver new digital tools that will boost the expected structural change in the current energy system at different levels: 1) generation, increasing the number of small power producers of renewable energy; 2) market, creating local energy markets that enable prosumers to trade energy volumes of their choosing within local communities; 3) distribution, establishing a multidirectional energy flow and promoting REC driven energy services, and 4) consumers, empowering consumers to be active and participating in the energy system and the design of their own Renewable Energy Communities (REC). The main objective of LocalRES is to demonstrate at TRL8 innovative local energy systems in a sector coupling approach, which will be able to interconnect and optimise the joint operation of different energy vectors (electricity, heating, mobility, etc.) by maximising the RES contribution and enhancing the energy system flexibility and supply security. The focus is on the renewable energy communities as main actors for leading the structural change in the current energy system towards the decarbonisation of the local energy systems based on an integrated multidirectional flow approach and prosumers, allowing to maximize the replicability and upscale the potential of the decentralized solutions developed in the project. The LocalRES solutions promote a secure, sustainable, competitive and affordable energy supply for everyone.

Keywords: sector coupling,renewable energy communities,multi energy virtual power plant,planning tool
Technology Evolution in Regional Economies (TechEvo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2023-02-28
Duration (months): 72.0
Total project cost (EUR): 1496599.0
EU funding (EUR): 1496599.0
Participants: 1
Project status: CLOSED

The creation and accumulation of knowledge are processes at the heart of technological change and economic growth. Attention has been directed at aggregate measures of knowledge production in regional and national contexts, but little consideration has been given to the properties of knowledge produced in specific places. How does the nature of knowledge that is produced vary over space, what conditions the scope of technologies generated in different locations, and how do these knowledge sets impact the performance of local firms and industries? To date, the way in which specific regional knowledge capabilities influence the evolution of local technology trajectories and thus shape geographies of economic prosperity have not yet been considered systematically. The objective of the “Technology Evolution in Regional Economies” (TechEvo) project is to address these significant shortcomings. Focusing on the evolution of scientific and technical knowledge, as indicated by patent, trademark and scientific literature records, the point of departure is the pan-European knowledge space for all 28 European Union member countries, plus Norway and Switzerland, over the time period 1981-2015. The knowledge space, based on the co-occurrence matrix of particular knowledge domains (629), maps the proximity of patent technology classes and enables the development of regional measures of knowledge specialization for all 1,369 (NUTS3) regions. Set in an evolutionary framework the investigation provides ground breaking insights into how innovative entities and individual inventors are embedded in social and cognitive local and non-local networks, and how regional technology trajectories are shaped through entry, exit, and selection processes. TechEvo will provide a wealth of indicators, models and tools that will assist firms and policy makers in place-based investment decisions, and deliver a science and technology policy evaluation tool capable of assessing impact.

Keywords: evolutionary economic geography,technological change,knowledge space,invention and innovation,science and technology policy,research and development,patent and citation analysis,related variety
Translating fundamental insights in endothelial metabolism: PFKFB3 drug discovery and development (PFKFBLOCK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-08-01
End date: 2018-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Angiogenesis, the growth of new blood vessels, contributes to major pathologies such as blinding ocular disease, inflammation and cancer. Blocking angiogenesis has therefore become a major field of research and an attractive therapeutic strategy. Current anti-angiogenic therapies focus on blockade of pro-angiogenic factors, such as VEGF. However, in cancer, insufficient efficacy, resistance and toxicity restrict the success of anti-VEGF agents. There is thus an urgent unmet need for novel anti-angiogenic strategies. In our ERC Advanced research grant (ECMetabolism), we developed an entirely novel anti-angiogenic concept and strategy, based on targeting key metabolic pathways in endothelial cells (ECs), cells lining blood vessels. More in particular, we identified - for the first time - that PFKFB3, a key glycolytic regulator, as a novel and promising target for anti-angiogenic therapy. Our findings show that glucose metabolism determines vessel sprouting and that lowering glycolysis only partially and transiently (by blocking PFKFB3) sufficed to inhibit pathological angiogenesis without causing systemic effects. In this ERC proof of concept project, PFKFBLOCK, we aim to develop lead small molecule compounds, blocking PFKFB3, and evaluate their potential to block pathological angiogenesis. Currently, no specific and orally available PFKFB3 blocker exists underscoring the value of our proposal and the necessity to develop such blocker for therapeutic applications. Through collaboration with a drug discovery unit we will identify lead molecules with novel intellectual property potential. Those lead compounds will be validated in relevant in vivo models and considered to be patented. The ultimate goal of this project is to get the best PFKFB3 inhibitor in clinical trials.

Keywords: angiogenesis,endothelial cell metabolism,drug discovery,small molecule compounds,anti angiogenic therapy
Developing Wireless Application-based Spray Printer Device for Wall Decoration (SPRAYDECO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Estonia
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of the innovation project is to improve and commercialize a new do-it-yourself wall art solution which enables to transfer pictures and designs directly from a computer or smartphone to wall surfaces without any artistic skills needed. The SprayPrinter team is currently developing an innovative wireless printer device which communicates with any smartphone camera through an app that controls the painting process. The device itself attaches to an aerosol spray can, allowing the design to be directly spray printed onto any wall surface. This spray printing technology is unrivalled on the marketplace today and will serve the needs of numerous target groups and end-users, including both existing artists and home users. The product falls in line with the do-it-yourself and maker trends that have been gaining traction globally and not only outperforms many of the larger competitors in terms of affordable, customizable wall art solutions but also offers a unique alternative to the more traditional means of interior decoration. Phase 1 activities are designed for verifying the technological and commercial feasibility of the innovative device and serve as input into elaborating the underlying innovation project.

Keywords: spray printing,wall art,decorative arts,do it yourself,wireless printer device,maker culture,customized art