Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An innovative, effective and minimally-invasive retinal cell therapy combined with a new injection system for treatment of retinal degenerative diseases. (EIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Retinal degenerative disease is a debilitating condition with a major impact on daily life. This includes Geographic Atrophy(GA) - as a consequence of age-related macular degeneration (AMD) - and advanced Retinitis Pigmentosa (RP) - all characterized by photoreceptor loss. In fact, they are the main causes of registered blindness. In this regard, there are no currently effective treatments for patients suffering from GA a and RP, leaving approximately 2.6 million people across Europe and over 5 million worldwide with the risk of developing severe visual impairments. Standard techniques to treat GA and DR, including Intravitreal Injections (IVTs) and subretinal transplantation present major problems associated with them. Everads developed a treatment for macular and retinal degeneration, utilizing the innovative Everads Injection System (EIS), a minimally invasive platform for optimal injection of Adult Bone Marrow Mesenchymal Stromal Cells (hBM-MSCs). Unique treatment approach allows simple, office-based safe transplantation of hBM-MSCs in the matrix between the choroidal blood vessels, providing excellent distribution very close to the target organ (retina) and long-term therapeutic effects, targeting multi-billion market opportunity. The Everads treatment is safe, minimally-invasive, can be performed in an office setting and ensures 80% drug distribution in the retinal area, aiming for longer lasting effect of drug. It also reduces the risk of side effects like increased Intra Ocular Pressure (IOP), glaucoma, cataract typical of IVT injections. During the feasibility assessment, a goto market strategy and a supply chain will be established, and further development plan will be drafted. During the phase 2 of innovation project, Everads will perform further product development and cell distribution and dosage escalation activities. Multiple first in human clinical trials will be initiated to obtain marketing license as a drug-device combination product.

Keywords: drug injection system,minimally invasive,retinal degenerative disease,suprachoroidal injection,drug device combination,hbm mscs,stem cell transplantation,geographic atrophy,retinitis pigmentosa
Graphene to Fight Antimicrobial Resistance (GRAPHFITI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-04-01
End date: 2022-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Today, antimicrobial resistance is emerging as a global burden, endangering our lives. Drug-resistant pathogens kill about 25,000 infected people solely in the European Union every year. In the fight against this crisis, rapid Antimicrobial Susceptibility Testing (AST) plays a crucial role. Although effective in discerning the right concentration of antibiotics required to inhibit the growth of a pathogen, conventional AST techniques are not fit for point-of-care, since they are slow and require large microbial inocula. The advent of graphene, and the ability to fabricate one-atom thick membranes, has made it possible to make miniaturised sensors that are extremely sensitive to nanoscale forces. During the research project ENIGMA carried out in the framework of the ERC Starting Grant no. 802093, we have developed a methodology that can probe nanomechanical motion of graphene membranes in the presence of bacterial cells. Here, I propose to further validate this technology and realize a proof-of-concept demonstrator that offers automated high throughput AST using massively parallelized graphene membranes. By eliminating the need for culturing large number of bacterial cells, GRAPHFITI has the potential to shift the current paradigm of AST technologies towards the use of atomically thin membranes with single bacterial cell sensitivity, thus enabling diagnostic tools for fast point-of-care screening of antimicrobial resistance.

Keywords: graphene,antimicrobial susceptibility test,nanomotion detection
Building pathways towards FOOD 2030-led urban food policies (FOOD TRAILS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Italy,Italy,Albania,Italy,Italy,Norway,Belgium,Poland,Sweden,Greece,France,France,Netherlands,Netherlands,Denmark,United Kingdom,Portugal,Denmark,United Kingdom
Call: FOOD 2030 - Empowering cities as agents of food system transformation (H2020-FNR-2020-1, 2020)
Start date: 2020-10-16
End date: 2024-10-15
Duration (months): 48.0
Total project cost (EUR): 12185827.14
EU funding (EUR): 11937057.5
Participants: 26
Project status: SIGNED

Meeting the challenges of providing European citizens with affordable, safe and nutritious food and of creating healthier and more sustainable City Region Food Systems raises the need for the development of integrated urban food policies that are able to engage with the complexity of the food system. Today’s leading platform for this endeavour is the Milan Urban Food Policy Pact, a powerful global network of learning cities experimenting around, and advocating for, the implementation of a holistic approach to food system transformation. FOODTRAILS, a four-year project led by the City of Milan, brings together a Consortium of 19 partners (including 11 EU cities, 3 universities and 5 prominent food system stakeholders), which will be followed by another 21 worldwide cities, to translate the MUFPP’s shared vision and collective commitment to integrated urban food policies into measurable and long-term progress towards sustainable food systems. Building on the momentum created by the recent emergence of cities as key sites to reimagine, enact and engage with food system transformation, FOOD TRAILS will provide city and regional governments and other agents of change with evidence-based policy narratives, co-designed and verified through the activities of 11 multi-objective and multi-actor Living Labs committed to addressing the 4 priority areas of the flagship FOOD 2030 framework. Using the existing knowledge on innovations for food system transformation, the Living Labs will co-design pilot projects that minimize the trade-offs between the 4 priorities of FOOD 2030 and that can function as an entry point for the development of integrated urban food policies. FOODTRAILS will also establish a pan-European Investors’ Living Lab to develop innovative financial instruments that will attract new resources to sustain the urban food policies developed during the project, maximize their visibility and support their replicability across the EU.

Keywords: city region food system,urban food policy,living lab,impact investment
Realistic, accessible, and affordable models for surgical education (ReSurg)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Türkiye
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Breast cancer is the most common cancer in women and the second in cancer-related deaths. There were over 2 million new cases in 2018 , and this number is continuously increasing. To remove breast cancer, there are two main types of surgery: 1) Breast-conserving surgery (lumpectomy, quadrantectomy, partial mastectomy, or segmental mastectomy): A surgery in which only the part of the breast that contains the cancer is removed; 2) Mastectomy: A surgery in which the entire breast is removed, including all of the breast tissue and sometimes other nearby tissues. There are several different types of mastectomies. Some women may also get a double mastectomy, in which both breasts are removed. The return of women to their pre-cancer lives depends on the medical and aesthetic success of the surgery that they are going to go through. Modern oncoplastic techniques that are focused on conserving the breast tissue offer a better pathway for patient health and recovery. In order to excel in these techniques, surgeons need practice which requires hands-on manipulation of the breast tissue. However, the shortage of cadavers and organ models hinders the quality of surgical education. The students/surgeons-in-training practice on the very patients that they are sworn to take care off. There is a need for a reliable and sustainable training medium for ever-growing number of medical students and personnel. ReSurg: offers new-to-the-world solutions, a breast model that aims to improve breast surgery medical training, and a self-awareness model, a poster with a tactile breast model that contains lumps which should not be there, a campaign that encourages women to follow up with their routine exams through somewhat scaring them.

Keywords: surgical simulation,breast model,surgical model,composite materials
A multifaceted platform for exploring nucleotide-based post-translational modifications (nbPTMs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Nucleotide-based post-translational modifications (nbPTMs) play key roles in health and disease, from bacterial pathogenesis to cancer. However, technical challenges of these versatile, but chemically complex protein modifications have constrained our fundamental understanding of even the most intensely studied nbPTMs for decades. The overarching aim of this proposal is to establish, apply and disseminate a methodology to unveil novel types of nbPTMs and allow site-specific proteomic analyses. The conceptual innovation lies in a strategy for turning the complex chemical structures of nbPTMs from a challenge to an advantage. First, shared chemical moieties will be exploited to develop pan-specific enrichment of multiple nbPTMs. For this purpose, we will generate the first nbPTMs-specific antibodies by converting specific signalling proteins into biotechnology tools for chemoenzymatic synthesis of challenging peptide antigens (aim 1). Second, we will take advantage of the chemical lability of nbPTMs to analyse modified peptides using a nucleobase-targeted mass spectrometry approach (aim 2). The unbiased scope of our methodology will make possible the discovery of as yet unknown forms of nbPTMs (aim 3) and nbPTM site mapping throughout eukaryotic proteomes (aim 4). These new materials, methods, discoveries and datasets will be made publicly available to allow future investigations of nbPTMs by the scientific community. The new substrates, sites and nbPTMs will provide starting points for biological characterization (aim 5). Poised at the interface of biology and technology, this interdisciplinary research project has the potential to explore new territories within established biomedical fields and to contribute to the knowledge base for improved treatment of diseases.
Synthetic Gauge Fields in Quantum Optics (SynOptic)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Synthetic gauge fields have many important physical consequences in quantum optical systems. This fast-growing topic of research is opening up new possibilities for the lossless optical transmission of information, for improved optical components, such as optical isolators, and even for fault-free topological quantum computing. We explore how to push cutting-edge experiments towards these goals by theoretically studying the interplay of synthetic gauge fields with optical nonlinearity, pumping and loss in photonic devices. The systems we shall investigate range from artificial graphene and other condensed matter models simulated with microcavities; to lattices of classical pendula and waveguides; to strongly correlated fractional quantum Hall-like states of light and their exotic excitations. Our work will have an immediate impact through international experimental collaborations and an interdisciplinary approach building on our combined range of expertise. We will exploit concepts and techniques from diverse research areas including quantum fluids, topological phases of matter, solid-state systems and non-equilibrium physics. Our project couples the investigation of novel phenomena arising from gauge fields in many-body systems with the hunt for new and improved technological applications in photonics.
MUTATION++ library, technology transfer from atmospheric entry plasmas to biomass pyrolysis (MUTX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-08-01
End date: 2018-01-31
Duration (months): 18.0
Total project cost (EUR): 149921.0
EU funding (EUR): 149921.0
Participants: 1
Project status: CLOSED

One successful outcome of the AEROSPACEPHYS ERC StG, entitled “Multiphysics models and simulations for reacting and plasma flows applied to the space exploration program,” is the development of a new software library called MUTATION++: MUlticomponent Thermodynamic And Transport properties for IONized gases in C++. The library compiles the state-of-the-art physico-chemical models and algorithms developed by the team into a highly extensible and robust software package to be coupled to simulation tools used by space agencies and industries. The design of the library allows for high-performance integration in material and flow field simulation tools. MUTATION++ is also shipped with several stand-alone tools that provide up-to-date basic data without proper software linking. Such a compromise allows simulation tool users, who do not have access to the source code, to benefit from these models. Taking community development to the next level requires the improvement and enrichment of the software testing framework and database, giving new users development guidelines and technology transfer examples. The MUTX project will allow us to extend the user base of MUTATION++ to the corporate community. This will require the implementation of tests to ensure the preservation of the library functionalities and performance after each new release and on multiple hardware and software platforms. It will also require the addition of databases for real thermal protection materials currently being developed by the space industry in collaboration with the European Space Agency. The demonstration of a transdisciplinary technology transfer will be achieved by implementing a database for biomass pyrolysis simulation. One long-term goal of the MUTX project is to enable the PI and his team to obtain additional funding through participation in research contracts in collaboration with industrial partners using MUTATION++.

Keywords: library software,regression testing,physico chemical database,atmospheric entry flows,biomass pyrolysis
Services in Support for Business and Innovation in Croatia - Key Account Management - SSBI-CRO-KAM4 (SSBI-CRO-KAM4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Croatia,Croatia,Croatia,Croatia,Croatia
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 37075.6
EU funding (EUR): 37075.6
Participants: 6
Project status: CLOSED

This action will establish and provide the innovation support services addressing in general Croatian SMEs with significant innovation activities and in particular the beneficiaries of the SME instrument, of Fast Track to Innovation (FTI) and Future and Emerging Technologies Open (FET-Open). This action will provide continuation of the SSBI-CRO-KAM-3 proposal which is currently implemented under the remit of H2020 for the period of 2017-2018. Based on the findings from previous actions and on the analysis of the needs and of the potential of the region (carried out through 1on1 consultations with other relevant partners/stakeholders supporting innovation in Croatia) the consortium defined service packages that will be delivered to the SMEs: • 8 service packages for Key Account Management (KAM) of successful SME beneficiaries of the funding schemes SME Instrument, Fast Track to Innovation (FTI) and Future and Emerging Technologies Open (FET-Open), with the aim to identify bottlenecks to creation of economic impact in companies benefiting from Horizon 2020 grants, • 15 service packages for Enhancing Innovation Management Capacity (EIMC), with the goal to improve clients’ capacity to manage innovation processes, increasing their efficiency and effectiveness. Project partners HAMAG-BICRO, TPV, TERA and STEPRI will each individually provide number of service packages according to the analysis of regional needs (regional coverage, number and readiness of clients). Direct impact from the Action will be a more effective and efficient conduction of innovation processes, and an enhanced growth and profitability of SMEs receiving the services.

Keywords: innovation,h2020,sme instrument,fet open
Boosting European citizens knowledge and awareness of bioeconomy (BLOOM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Coordination and support actions
Countries involved: Austria,Austria,Germany,Spain,Germany,Austria,Belgium,Sweden,Finland,Poland,Poland,Netherlands
Call: Strategies for improving the bioeconomy knowledge of the general public (H2020-BB-2017-1, 2017)
Start date: 2017-11-01
End date: 2020-12-31
Duration (months): 38.0
Total project cost (EUR): 2400000.0
EU funding (EUR): 2400000.0
Participants: 14
Project status: CLOSED

The main objective of this project is to establish open and informed dialogues, co-created by European citizens, the civil society, bioeconomy innovation networks, local research centers, business and industry stakeholders and various levels of government including the European Commission. BLOOM will elaborate five hubs (communities of practice) that will allow for an iterative process that involves with all stakeholders through various cycles of value development, enabling cross-fertilization and idea generation through shared knowledge and experiences. In co-created workshops outreach activities will be designed, explored and validated that are exactly adapted to the regional needs of the stakeholders. The interactions aim to (a) raise awareness and knowledge on bioeconomy by enabling open and informed dialogue throughout the bioeconomy innovation processes (b) build up and strengthen a bioeconomy community, (c) gain a common understanding of the concept, providing reliable insights into bioeconomies, its practices, benefits and implications (d) foster learning and education. With that, the project will support the reduction of existing barriers towards a bioeconomy and stimulate bioeconomy activities at the regional and EU level.

Keywords: bioeconomy,outreach,arts,public engagement,science education,formal education,co creation,transdisciplinary research,interdisciplinary research
DOES IT PROMOTE ECONOMY AND WELL-BEING? THE IMPACT OF TELEWORKING ON ENVIRONMENT AND LABOUR MARKET OUTCOMES (TELE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

This project examines the telework effects on environment and labour market outcomes. More specifically, the first aim of the project is to analyse the link between job satisfaction, labour productivity and firm performance. The second aim is to examine the effects of teleworking on labour productivity/job satisfaction and environment (e.g. traffic, air pollution). The final aim of this study is to examine how teleworking affects the labour market and housework division between men and women. Two databases are used; the Workplace Employment Relations Survey (WERS) and British Household Panel Survey (BHPS). Various econometric techniques are applied, such as Fixed Effects and Dynamic Generalized Methods of Moments (GMM) models Instrumental Variables (IV) and Generalized Latent Class Ordered Probit Models, Seemingly Unrelated Regressions (SURE) and Three Stage Least Squares (3SLS).

Keywords: air quality,gender roles,housework division,job satisfaction,labour productivity,teleworking,traffic,well being