Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quasars in a Neutral Universe: Chronicling the History of Reionization, Enrichment, and Black Hole Growth (QuasarChronicles)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 2496073.75
EU funding (EUR): 2496073.75
Participants: 1
Project status: SIGNED

How the first luminous sources reionized diffuse baryons in the intergalactic medium (IGM) is one of the most fundamental open questions in cosmology. The latest CMB constraints suggest reionization occurred at z ~ 7-8, within the realm of the highest redshift quasars known. The overarching impetus of this proposal is that Euclid's imminent discovery of scores of bright quasar beacons in a neutral universe, combined with the exquisite sensitivity of JWST, will enable a set of qualitatively new absorption spectroscopy experiments. Abundant neutral hydrogen in the IGM imprints a distinct damping wing signature on quasar spectra, which we will exploit to obtain the best constraints on the timing of reionization to date. These same spectra provide a glimpse of baryonic structure prior to reionization, which we will use to determine whether X-rays emitted by primeval black holes during cosmic dawn pre-heated the IGM, and constrain the properties of the underlying dark matter. The quasar's own ionizing radiation powers a cosmological-scale HII region encoding its radiative history, which we propose to map in absorption to answer the enigmatic question of how supermassive black holes grew to 10^9 M_sun just 800 Myr after the Big Bang. The same massive stars which reionized the IGM inevitably exploded in supernovae polluting the Universe with metals. These metals, if they reside in the neutral IGM, manifest as a forest of low-ionization absorbers, which we will use to constrain early IGM enrichment, and trace the history and topology of reionization with cosmic time. By conducting end-to-end analyses encompassing observations, theoretical modeling, state-of-the-art simulations, and Bayesian inference, we will elevate the quantitative study of reionization to be on the same solid methodological and statistical footing as other precision cosmological measurements. The PI is uniquely positioned to achieve these goals and has a proven track record for this type of synergy.

Keywords: the intergalactic medium,reionization,cosmic dawn,quasar absorption lines,the growth of supermassive black holes,cosmic enrichment
Mobilising the World: A New History of Inter-Allied Cooperation in the Second World War, 1939-1945 (INTERALLIED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

In the Second World War, the Allies waged war on a truly global scale for the first and, one hopes, last time in history. Victory required the mobilisation and transportation of wo/men and materiel on all continents and across four out of the Earth’s five oceans. Success would have been impossible without extensive inter-Allied coordination, organisation and planning. Starting in 1939, a system of inter-Allied organs was set up by Britain and France, whose mission it was to coordinate the supply of the Allied war effort from a common pool. It survived France’s fall in 1940 and, upon US entry in 1941, was revived. By 1942, it had evolved into a global network of military, production and logistics experts from India to Canada and South Africa to Norway, organised into a series of so-called Combined Boards and dedicated to the nuts and bolts of worldwide coalition warfare. Yet we lack a history of this extraordinary organisation. Despite the Second World War’s self-evidently global nature, the tendency to frame it in national, comparative and Eurocentric terms is very deeply entrenched. INTERALLIED, by contrast, seeks to highlight the global, transnational and interdependent character of the Allied war effort. The project asks: how did the Allies seek to couple, then uncouple their war economies, and mobilise (then demobilise) global markets for war, between 1939 and 1945? It seeks (1) to provide an account of the political economy of global Allied warfare, and thus to reach for a history of the global economy at war, which has yet to be written; (2) to advance a recent 'global turn' in Second World War studies, and thus to resist nationalistic and Eurocentric readings of the conflict, frequently deployed politically today; and (3) to produce new, practical knowledge about how societies can cope with massive shocks to their systems of supply, production and trade, and prevent damaging and wasteful competition for scarce resources.

Keywords: second world war
The Mediation of Climate Change Induced Migration. Implications for meaningful media discourse and empowerment of key intermediaries to raise public awareness (IKETIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-03
End date: 2019-04-02
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The IKETIS project will seek to raise awareness in the UK of the need for action to address climate change induced migration and will focus on the mediation of the climate refugees’ issue. The first aim of the action is to understand the representational practices that shape media and NGOs discourse about climate refugees. The second aim is to build capacity of journalists, NGOs and policy-makers, key intermediaries in the mediation of climate change induced migration, to enhance social support for policy actions. Together, both aims contribute to the transformation of how climate change induced migration is perceived and provide new patterns of critical thinking and civic engagement. The research consists of four phases: i) identify the policy, institutional and definitional factors that may impede meaningful media discourse on the issue ii) perform critical discourse analysis (image and text) and frame analysis of the representations of climate change induced migration of UK online news media iii) using these findings, then move on to examine how UK humanitarian and environmental NGOs utilise and challenge frames identified by online news media coverage of climate displacement and iv) based on the understanding of the representational practices that formulate climate refugees mediated discourse, promote climate justice approach to frame climate change and build capacity of journalists, NGOs and policy-makers to best use climate justice approach through e-learning strategies. This training-through research scheme will provide the applicant with the necessary skills to develop competences in media theory, visual communication, critical discourse and frame analysis and digital media research and plan an academic career track for a better integration into the academic community, while the applicant will be of specific benefit to the research-informed teaching that forms the basis of the host institution’s approach to undergraduate and postgraduate teaching practice.

Keywords: environmental communication,climate change communication,climate refugees
Electrophilic-induced asymmetric boronate rearrangements via CAPT catalysis. A novel approach towards the formal trifunctionalization of alkenes. (HALOBORYLATION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2019-10-31
Duration (months): 24.0
Total project cost (EUR): 171792.6
EU funding (EUR): 171792.6
Participants: 2
Project status: CLOSED

This proposal describes an unprecedented, enantioselective haloborylation reaction through the innovative application of chiral anion phase-transfer (CAPT) catalysis to electrophilic-induced boronate rearrangements. Beyond the development of an orthogonal approach towards the formal trifunctionalization of alkenes, the proposed methodology provides easy access to biologically and synthetically important products, and is anticipated to have great impact in the area of diversity oriented synthesis.

Keywords: asymmetric catalysis asymmetric borylation diversity oriented synthesis organofluorine chemistry
Role of autonomous B cell receptor signalling and external antigen in the pathogenesis of chronic lymphocytic leukaemia (CLL) (Autonomous CLL-BCRs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2021-10-31
Duration (months): 60.0
Total project cost (EUR): 2256250.0
EU funding (EUR): 2256250.0
Participants: 1
Project status: CLOSED

The proposed project aims at investigating the molecular mechanisms that activate B cell antigen receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL). While it is widely accepted that the unbroken BCR expression in CLL cells is indicative for a key role in disease development, the mechanisms that induce BCR activation and survival of malignant cells are still elusive. Using a unique reconstitution system, we have recently shown that CLL-derived BCRs possess the exceptional capacity for cell-autonomous signalling independent of external antigen. Crystallographic analyses confirmed our model that CLL-BCRs bind to intrinsic motifs in nearby BCRs on the very same cell. In addition to the BCR, several pathogenic factors influence the biological behaviour of CLL cells, but the functional hierarchy and the effect on BCR signalling are insufficiently understood. Here, we aim at investigating the structural cause of autonomous signalling as well as the characterization of important signalling pathways and their mechanistic action in CLL pathogenesis. By combining crystallography with the measurement of autonomous signalling of wild type and mutated receptors in our unique reconstitution system, we will generate a structure-function relationship for CLL-BCRs. By generating new animal models and by employing classical as well as cutting-edge approaches of biochemistry and molecular/cellular immunology, we will comprehensively characterize the signalling pathways that are activated by autonomous signalling and might be important for CLL pathogenesis. These systematic efforts are necessary to understand how various biological mechanisms operate and ultimately activate downstream pathways that result in a lymphoproliferative disease. In addition, a cohesive model of CLL pathogenesis, which elucidates the hierarchical order of pathogenic factors and their interaction with BCR signalling, may well lead to novel disease-specific preventive or therapeutic intervention.

Keywords: chronic lymphocytic leukaemia,b cell antigen receptor,haematology,oncology
Lower bounds for partial differential operators on compact Lie groups (LieLowerBounds)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

The theory of partial differential operators is one of the most important branches of mathematics with several consequences in many other mathematical fields and with applications in other sciences. This project, which is of theoretical nature, intends to investigate the validity of the Fefferman-Phong, the Hörmander and the Melin inequalities for partial differential operators, and in general for pseudo-differential operators, on compact Lie groups, and apply them to the problem of solvability of degenerate partial differential operators. The analysis of partial differential operators requires the study of geometric quantities attached to the operators, in particular, the (total) symbol, the principal symbol and the subprincipal symbol. However, in the context of compact Lie groups, the principal symbol is globally well-defined but it is not the same for the other symbols mentioned above. Our goal is to define in a suitable way the other geometric quantities needed in the analysis of the problem and use them to obtain lower bounds for partial differential operators on compact Lie groups (i.e. the Fefferman-Phong, the Hörmander and the Melin inequalities). These lower bounds will be used to treat the problem of solvability of partial differential operators on compact Lie groups. We remark that the validity of these inequalities will yield the development of several results in the theory of partial differential equations on compact Lie groups, as, for instance, in the problems related to solvability, hypoellipticity, and well-posedness of the (weakly-hyperbolic) Cauchy problem.

Keywords: lower bounds,partial differential operators,compact lie groups
The Ethical Hacking Platform - Sharing Economy for Security Testing (Intigriti)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-10-01
End date: 2019-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As data breaches are costly, companies spend billions to prevent them. Nevertheless, security breaches are increasing over the years. In other words, current security testing is limited as this is based on snapshots, influenced by the human factor and slow. Our intigriti platform represents a new approach to security testing: as opposed to the current manual ad-hoc testing, we are running a crowdsourced security platform where security researchers (ethical hackers) and companies wanting to prevent security breaches meet. We offer intigriti as a managed service where reports submitted by researchers are validated by use before they are forwarded to companies. On the demand-side, companies pay a monthly fee to display descriptions on what can be tested. When a report is valid, they pay a reward (bounty) to the researcher who submitted and we withhold a reward (bounty fee). We founded intigriti in August 2016 and launched the first intigriti version (i.e. gritti) in March 2017. Within a few months, we generated revenues of €460,000 from companies headquartered in Belgium with a global presence. Several investors have already spotted us and invested almost one million euros together with the founder who owns the majority share of the company. The total market for security testing is in the 10-digit range and our immediate target market is over €200 million. Our main competition are two US companies who we can keep at bay by being the first to market in Europe, which makes the SME instrument funding crucial for us. With intigriti entering all of Europe, citizens will benefit from much better data security and a minimized risk of identity theft as the intigriti ethical hackers help European companies stay one step ahead of malicious outsiders. In other words, before any citizens can get exposed to risks, our intigriti researchers have already found the gap and the company has already fixed it.

Keywords: security testing,data protection,penetration testing,ethical hacking
Injection Moulding Repurposing for Medical Supplies enabled by Additive Manufacturing (imPURE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced manufacturing and processing
Action type: Innovation actions
Countries involved: Italy,Italy,Italy,Spain,Spain,Ireland,Italy,Norway,Greece,Belgium,Greece,Slovenia,France,United Kingdom,United Kingdom
Call: Repurposing of manufacturing for vital medical supplies and equipment. (H2020-SC1-PHE-CORONAVIRUS-2020-2-NMBP, 2020)
Start date: 2020-12-01
End date: 2022-05-31
Duration (months): 18.0
Total project cost (EUR): 7261637.5
EU funding (EUR): 5783800.0
Participants: 21
Project status: CLOSED

The modern world is fast-evolving, interconnected and highly mobile, thus posing a significant challenge in harmonizing risk mitigation measures against emerging biological hazards. For many years the risk of emerging infectious diseases with pandemic potential was declared a major threat to global health security and addressed by many stakeholders around the world. The delay in imposing risk mitigation measures is crucial and can make the difference between a local outbreak with few cases to a pandemic with countless sick and deceased citizens, as severely demonstrated by the recent outbreak of Coronavirus disease 2019 (COVID-19). It is of paramount importance that appropriate and proportionate measures to each phase of the pandemic (e.g. from situations with no reported cases, sporadic, local clusters of cases, to widespread sustained transmission) are immediately implemented to interrupt human-to-human transmission chains, prevent further spread and reduce the intensity of COVID-19 outbreak. Immediate activation of national emergency response mechanisms and pandemic preparedness plans to ensure containment and mitigation of COVID-19 with non-pharmaceutical public health measures is critical for delaying transmission or decreasing the peak of the outbreak, in order to allow healthcare systems to prepare and cope with an increased influx of patients. However, shortages and other gaps in the global medical supply chain represent a mismatch of supply and demand when supply is low and/or demand is high for particular items. With healthcare workers and other first responders feeling the impact of supply chains disrupted by unprecedented challenges, many large and small businesses from outside the traditional healthcare procurement system are reconfiguring to mass produce critical medical consumables. In order to address supply shortages, particularly in medical supplies and protective equipment, some countries have employed less traditional instruments.
Digital Social Innovation for Europe (DSI4EU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Switzerland,Netherlands,United Kingdom
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2015, 2015)
Start date: 2016-02-01
End date: 2017-05-31
Duration (months): 16.0
Total project cost (EUR): 684526.0
EU funding (EUR): 584995.0
Participants: 4
Project status: CLOSED

The DSI4EU project will support, grow and scale the current Digital Social Innovation network of projects and organisations, bringing together social entrepreneurs, hackers, communities and academics working on key DSI fields such as the makers movement, the collaborative economy, open democracy and digital rights. DSI4EU will foster digital innovations for the social good, helping communities share data, collaborate to solve societal problems and scale their initiatives focusing on open and distributed technologies and new sustainable business models. DSI4EU will develop and upgrade the digitalsocial.eu platform, to promote large-scale collaboration and support experiments among the DSI community and activate collective awareness with a large number of citizens across Europe. DSI4EU will also provide an engaging programme of training, mentoring, events, policy workshops and experimentation. DSI4EU will represent the building blocks for a new participatory innovation model for Europe, a more decentralised web and an inclusive and sustainable society, including a radical approach to scaling, extending and connecting th DSI network in Europe.

Keywords: collective awareness platforms,social impact,makers movement,collaborative economy,open democracy and digital rights,support grow and scale