Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scalable Manufacturing of Organic Nano Devices for Electronics and Photonics (SMONDEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This research activity aims to demonstrate an economically viable and scalable nano-manufacturing method using a modified Chemical Vapor Deposition technique and a nano pattern transfer method based on silicon nanomembrane technology for the fabrication of nanostructured polymeric device components for electronics and photonics. The multidisciplinary nature of the proposed research will fuse science and engineering to overcome technological roadblocks for heterogeneous integration of polymeric materials into conventional micro- and nano-fabrication processes. The economically viable and scalable nano-manufacturing methods will enable the use of polymeric materials in conventional & future device designs opening new opportunities for electronic and photonic applications. The research will also address the need for novel polymeric materials with better chemical and thermal stabilities, and scalable processes that can take advantage of these chemistries to fabricate electronic/photonic devices reliably at low temperatures and at a reduced cost. The proposed method of integration of polymeric nanostructures into conventional nano-fabrication processes is scalable to a wafer size process and can also be optimized for roll-to-roll processing. The proposed work will advance the use of polymeric materials in semiconductor manufacturing in a real and significant way.

Keywords: physical sciences,materials engineering,nanodevices,chemical engineering,c122 thin films,c128 nanomaterials,g205 micro- and nanoelectronics - optoelectronics
TESTING GALACTIC WINDS AGAINST PREDICTIONS (GALACTICWINDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Theoretical models of galaxy formation predict that feedback from supernovae plays a crucial role in regulating star formation in low-mass galaxies. Efficient feedback, with large outflow rates, is needed in these models to account for the low-efficiency of galaxy formation in low-mass halos. Current constraints on mass outflow rates in this low mass regime are very sparse and the best estimates are uncertain by orders of magnitude. In order to test feedback models, we selected a unique sample of ~50 star-forming galaxies all near background quasars. The advantage in using background quasars over traditional galaxy spectra is that the kinematics and location of the cool gas is known, given by the impact parameter. Hence, the mass outflow rates can be determined more accurately with this technique. Our sample is the largest sample of galaxy-quasar pairs with deep IFU kinematics of the host galaxy and the line-of-sight kinematics with high-resolution optical spectroscopy. With these data we will answer the fundamental question: Are the mass outflow rates higher than the star-formation rates as predicted by theory? More importantly, we will be able to determine whether these depend on the galaxy mass or star-formation rate. Hence, our results will be a huge step forward and provide a strong bench mark for models. Furthermore, the "Multi Unit Spectroscopic Explorer" (MUSE) -- to be commissioned in 2013 -- with its unprecedented overall throughput, excellent stability and large field of view will be a very powerful tool to study galactic winds. Indeed, it will provide exquisite data on dozens of galaxy-galaxy pairs and quasar-galaxy pairs. Because, the host institute IRAP (Toulouse, FR) is part of the MUSE consortium, and has experts in the field, it will be an ideal place to conduct this research program.

Keywords: p301 astronomy - astrophysics and cosmology
SITE-SPECIFIC DNA REPLICATION PERTURBATION AND ITS EFFECTS ON CHROMOSOME SEGREGATION (REPBLOCK)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Denmark
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-06-01
End date: 2018-05-31
Duration (months): 60.0
Total project cost (EUR): 2456760.0
EU funding (EUR): 2456760.0
Participants: 1
Project status: CLOSED

Challenges to the stable maintenance of the human genome can come from both endogenous and exogenous sources. However, one of the major threats to genome stability occurs during normal DNA metabolism. The genome is particularly susceptible to perturbation during the S-phase of the cell cycle when DNA replication occurs. This is because DNA replication forks can encounter chemical adducts, DNA secondary structures, topological constraints or bound proteins that hinder their progression. In actively proliferating cells, such as stem cells, replication perturbation can lead to fork stalling, breakage or collapse. These scenarios can, in turn, generate deleterious chromosomal rearrangements that have the potential to initiate human disease. Despite recent advances in our understanding of the biochemical process of DNA replication, the precise details of the events occurring at sites where replication forks have been perturbed remain poorly characterised. This is because in-depth analysis of the perturbation of replication represents a major technical challenge, principally because adducts and lesions generated by DNA damaging agents are randomly distributed throughout the genome at sites that cannot be controlled or predicted. To overcome this technical limitation, we have developed systems for site-specific perturbation of DNA replication that can be transferred to any locus in any cell type. The aim is to define how replication fork perturbation is detected and engaged by cellular stress-response factors, and then tolerated or repaired. This highly integrated proposal, and the pioneering technologies that will be used to fulfil our ambitious aims, will have significant implications for the understanding not only of replication perturbation and its effects on chromosome dynamics in mitosis, but also of the role of replication stress in the aetiology of cancer and premature ageing. It will open up new horizons both in and across these fields of research.

Keywords: site-specific dna replication blockade,chromosome missegregation,bloom's syndrome,anaphase bridges,pich protein
Self-Assembled Monolayers over Ferromagnetic Electrodes for Organic Spintronics (SAMSFERE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-12-01
End date: 2015-11-30
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Organic materials offer unique properties like: i) processablility and plastic technology compatibility, ii) monodispersity and tunability and iii) long time spin coherence that make them appealing for spintronics devices and hence, a great number of proposals exits about its use in spintronics applications. Nevertheless, organic spintronics is in its infancy and so far only a small number of different organic materials have been used in spintronic research to realize an even smaller number of this proposals. First reports on the integration of organic materials into spintronic devices date back to 2002. Self-assembled monolayers with their special characteristics are an invaluable tool set for the developing and understanding of spin transport. As tunnel barriers SAMs i) Can be easily engineered: Are modular and their parts can be exchanged while keeping the others unchanged, ii) Are intrinsically nanometre thick: Film thickness will be determined by molecule size and SAM structure, iii) Have defined structures: SAM formation is a self-assembly process, structure is preprogramed and iv) Are promising to candidates to work at high-bias. SAMSFERE aims to expand the current know-how in the field of organic spintronics and lay the base of a solid understanding of the spin-transport through interfaces by the growing of a completely new set of SAMs over FM electrodes that will be employed in the development of devices based on magnetoresistive effects(organic magnetic tunnel juntions) and beyond (spin organic light-emmiting diodes).

Keywords: c105 surface science,c122 thin films,c141 organic chemistry,p205 electronic properties of materials and transport,p210 spintronics,p214 molecular electronics,p321 surface physics
Synthesis of Biomass Sourced Value Added Chemicals by Hydrothermal Electrolysis Technique (HYDELTECH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposed research aims to demonstrate a novel environmentally friendly process called ‘Hydrothermal Electrolysis’ by which organic materials in aqueous solution (with any suitable electrode) can be electrochemically converted into other valuable chemicals using only sub-critical water as a solvent. Hydrothermal electrolysis is normally carried out at a temperature range of 200-300 Celsius and 5-10 MPa reaction pressures and does not require the use of any catalysts, leading to a cost effective process. In this research activity, biomass will be decomposed into its building blocks and then converted into high value chemicals which have a huge potential to be used in different fields such as pharmaceuticals, intermediates for synthesis of new chemicals, coating, food industry, detergents, cosmetics, etc. by electrolysis in sub-critical water reaction medium without the formation of secondary pollutants indicating the greener point of view of this technique. The multidisciplinary nature of the proposed research will combine engineering and science to overcome the difficulties in the production of value-added chemicals from organic wastes by hydrothermal electrolysis, minimizing the amount of energy consumed for electrolysis with remarkable properties of sub-critical water. This research will advance the application of electrolysis in sub-critical water reaction medium to synthesize value-added chemicals with high yields from organic wastes efficiently and environmentally friendly manner.

Keywords: eng hydrothermal electrolysis,biomass,sub-critical water,c114 chemical reactions,v101 environment and sustainability,g302 chemical engineering,g316 production technology - process engineering
Understanding functional drivers in two terrestrial key processes- nitrogen fixation and cellulose degradation- by a single cell approach (DW_FDTP_UVA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The terrestrial C and N cycles are essential for the Earth’s biosphere and intimately linked by microbial activity. Understanding the participants and drivers rendering biologically available N is imperative as N is a limiting factor for primary production. Soils contain the largest pool of C on Earth with cellulose being a major constituent of this C. Therefore understanding this process is essential since it can either promote C sequestration or be a source of atmospheric CO2. My NanoSIMS group in the Department of Microbial Ecology at the University of Vienna focuses on the investigation of two microbial key processes; plant polymeric carbon degradation and nitrogen fixation. Our goal is to understand the active drivers of these processes and their in situ contributions, the degree of efficiency and regulation mechanisms using a multidisciplinary approach combining methods of biogeochemistry, molecular biology, ecology, soil science, and bacterial physiology. It is timely to now apply a functional approach to study the aforementioned processes due to the recent advance in single cell approaches. To identify the active participants of the two processes, we propose to combine stable isotope probing experiments (15N2 gas or 13C-cellulose) with cell identification with FISH/HISH, Raman microspectroscopy and NanoSIMS. These single cell techniques allow comparing the in situ activities of different microbial groups and the analysis of within population heterogeneity. We aim to differentiate the contributions of cellulose-degrading fungi and bacteria, as well as targeted groups within the bacteria. Second, we aim to better characterize participants in soil N2 fixation with particular emphasize on novel groups who are believed to be highly active. The synthesis of stable isotope probing experiments with single cell genomics will allow us to identify novel microorganisms of the targeted function and describe their ecophysiology in the soil.

Keywords: biogeochemical cycles,soil,diazotrophs,nitrogen fixation,nifh,cellulose degradation,stable isotope probing,single cell analysis,nanosims,raman microspectroscopy
Route to Low-cost, High-energy, and Tunable Femtosecond Laser Technology Based on Diode-Pumped Cr:Colquiriites (FS CR:COLQUIRIITES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Ultrafast laser technology is an active research field focusing on the development of advanced, high-performance femtosecond lasers in different wavelength regions for diverse applications in science and engineering. The venerable Ti:Sapphire lasers and amplifiers have always been the workhorse of ultrafast technology; however, they are quite bulky, inefficient and expensive, mainly due to lack of suitable pump diodes at the green region of spectrum. The cost and complexity of fs Ti:Sapphire sources are significant hurdles to its widespread adoption, slowing down progress in several important areas of research. We propose to develop a new generation of compact, ultra low-cost, highly efficient, and broadly tunable femtosecond technology based on diode pumped Cr:Colquiriite lasers and amplifiers. The proposed system will significantly reduce the complexity in pumping geometry of Cr:Colquiriites by using recently available high brightness tapered diode lasers. We propose to use multipass-cavity, cavity dumping, and regenerative amplification techniques to scale up pulse energies from Cr:Colquiriite systems to 350 uJ level (two orders of magnitude improvement over the previous results). We propose to use novel oxidized broadband saturable absorber mirrors to extent the tuning range of femtosecond Cr:Colquiriite laser oscillators to 750-1000 um region. Furthermore, using sum frequency generation and optical parametric oscillation/amplification, we will extend tunability of the femtosecond Cr:Colquiriite sources into the near infrared (1-3 um), visible (375-750 nm) and blue to UV (190-330 nm) regions of the spectrum. Lastly, we will develop compact, high repetition rate (5-20 GHz) Cr:Colquiriite oscillators and investigate their usability in optical metrology. If we can succeed, the proposed developments will help wider spread use of low-cost femtosecond technology, which we hope to accelerate and transform fundamental research in several important areas of science.

Keywords: optics,photonics,lasers,amplifiers,solid-state lasers,mode-locked lasers,tunable lasers,diode-pumped lasers,ultra-short pulse lasers and amplifiers,cr:colquiriite lasers,saturable absorbers
Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy (UCNANOMAT4IPACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-01-15
End date: 2017-01-14
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Upconversion nanoparticles (UCNPs) have outstanding optical and magnetic properties, which make them extremely suited for application in cancer phototherapy and imaging. They efficiently convert low energy near infrared (NIR) light to higher energies in the visible. The so-generated upconverted luminescence can be exploited to photoactive anticancer metal complexes, a promising class of compounds studied as novel photochemotherapy agents. UCNP-mediated NIR activation will allow overcoming metal complexes’ light absorption limitations, simultaneously achieving considerably higher tissue penetration and preserving photochemical reactivity. Indeed, the rich photochemistry of metal complexes can result in unique cell killing modes, critically important in the development of novel anticancer prodrugs. The project aims at investigating the use of UCNPs in the photoactivation of promising anticancer metal complexes, and more specifically at developing new nanomaterials where these two components are integrated to give a superior prodrug. Anchoring photoactive anticancer coordination compounds on UCNPs can produce materials with optimal photophysical and photochemical properties for chemotherapy. Moreover, the chemical versatility of UCNPs offers opportunity for functionalization with biological vectors, which improve biocompatibility, targeting and selectivity features of these integrated nanomaterials in cells and tissues. Remarkably, UCNPs are also excellent new candidates for multimodal (optical/MRI/PET) bioimaging. Their upconverted luminescence, magnetic resonance relaxivity and radioactivity (ease of 18F-labeling) will serve to visualize fundamental biological events with high spatial resolution, which are key to study the photoactive nanomaterials’ anticancer action as well as for their medical use. All such features combined together have the potential to deliver innovative therapeutic and imaging agents for cancer phototherapy.

Keywords: transition metal complexes,nanoparticles,upconversion,photochemotherapy,photoactivation,photochemistry,dft,x-ray,pdt
Dynamic Signal Transduction in Individual Cells (DYNASTIIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Regulation of proliferation and differentiation is a fundamental challenge for multicellular organisms. The decision between alternative cell fates is therefore tightly controlled by cellular signaling. During the past decades, the central components of the signaling machinery have been identified. The challenge we are facing now is to understand how signaling networks act dynamically in living cells and how they intersect with each other to control the physiological response of a cell. Since signaling networks contain complex, non-linear interactions that are difficult to understand intuitively, it will be important to use an interdisciplinary approach, combining quantitative experiments and theoretical analysis. As cellular decisions often vary even in genetically identical cells depending on the initial conditions and the micro-environment, we have to measure signaling on the level of individual cells. In the proposed project, we will investigate the TGFbeta pathway, a central growth-inhibitory pathway in epithelial cells. We will acquire quantitative data with high temporal and spatial resolution using time-lapse microscopy of live fluorescent reporter cells and combine it with mathematical modeling. Using this approach, we will determine how the structure of the network shapes its dynamic response, how activation of the signaling pathway is translated into changes in cellular physiology and how TGFbeta interacts with other networks to control cell fate. The resulting mechanistic understanding will enable us to manipulate cell decisions in-vivo and develop therapeutic interventions to regain control over aberrant signaling processes diseased cells. After a postdoc at Harvard Medical School, the applicant is moving back to Europe to start a career as an independent researcher in Germany. Funding of the proposed research will provide significant support for the reintegration process and will foster the transfer of knowledge to the European research community.

Keywords: l213 systems biology,l301 morphology and functional imaging of cells,l308 signal transduction,l214 biological systems analysis - modeling and simulation,l303 cell cycle and division