Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular Mechanisms of Cerebral Cortex Development (MOMECODE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The cerebral cortex, the seat of our cognitive abilities, is composed of an intricate network of interconnected neurons. The cortical cytoarchitecture consists of distinct layers with different cellular composition and function. Due to an immense heterogeneity in the cortical neuron types it is currently not known how many classes and which subtypes of cortical neurons make up the distinct cortical microcircuits in different functional cortical areas. The precise mechanisms of how these neurons coalesce into defined laminae and form specific connections with their synaptic partners during development are not well understood either. In a pursuit to obtain in-depth insights into these fundamental questions, we assess corticogenesis at unprecedented single cell resolution using the unique genetic strategy called MADM (Mosaic Analysis with Double Markers). MADM technology offers an unparalleled approach to visualize and concomitantly manipulate sparse clones and small subsets of genetically defined neurons in mice. Within the scope of this project we will use multidisciplinary experimental approaches including but not restricted to mouse genetic techniques and MADM, high resolution 4D live-imaging, and gene expression profiling. It is our objective to establish a research program with the following major aims: 1) Determination of cortical neuron lineages by clonal analysis; 2) Dissection of the molecular mechanisms of cortical neuron migration and 3) Probing of genomic imprinting, an epigenetic phenomenon, in cortex development. Together, these research directions shall precipitate into significant conceptual progress regarding the fundamental cellular, molecular and epigenetic principles of cerebral cortex development. Ultimately, such advances may result in a deeper understanding of brain function and of why human brain development is so sensitive to the disruption of particular signaling pathways in pathological neurodevelopmental or psychiatric disorders.

Keywords: madm,mosaic analysis with double markers,cerebral cortex development,clonal analysis,neurogenesis,neuronal migration,genomic imprinting
Biogeography and metapopulation genetics of understudied hydrozoan reef foundation species Millepora spp. (HYDROREEF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Reef ecosystems are one of the most threatened environments on Earth. Because they provide invaluable services to coastal communities and sustain a large part of global biodiversity, the conservation of their biodiversity and functioning is vital. Millepora species are the second reef builders after scleractinians, yet little is known about them. Such foundation species, providing shelter, food and nurseries to thousands of species are essential to protect. The project “HydroReef” aims to characterize biodiversity and metapopulation dynamics of millepores through a multidisciplinary approach involving DNA barcoding, phylogeny, comparative phylogeography and population genetics on various spatiotemporal scales. DNA barcoding will accurately assess biodiversity in this problematic group. Phylogenetic reconstructions in light of geography and dating will reveal the drivers of speciation in the genus. Comparative phylogeography will help identify common evolutionary processes and biodiversity drivers among widespread Indo-Pacific species (e.g. barriers and refuges). A particular focus will be to identify past population size changes related to palaeoclimate variations. Population genetics using microsatellites and SNPs (genomic perspective) coupled to individual-based methods will provide estimates of ecological connectivity (DNA tracking of dispersal) and effective population sizes. The respective role of asexual and sexual reproductions on population persistence will be uncovered. This study will improve our understanding of some striking patterns of biodiversity (e.g. Indo-Australian-Archipelago biodiversity hotspot) and give an unprecedented view of millepore ecological functioning. It will provide information directly enhancing the protection and restoration of coral reefs. It will reveal regions of evolutionary importance and the spatial dimension of millepore connectivity, crucial information for both global scale conservation and design of Marine Protected Areas

Keywords: asexual reproduction,biodiversity,connectivity,conservation,dna barcoding,effective population size,glacial refuge,potential of resilience,scenario-testing,source-sink population,speciation
Integrating Mobile Applications into Teacher Education (TEACHEDMOBILE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Europe needs to equip its young population with digital competencies to gain and maintain its competitive advantage in the global economy. This need, as recognized by the European Commission, clearly requires a concerned research effort in preparing future teachers with necessary skills to integrate mobile applications into learning and teaching settings. Main purpose of this project is to provide, through research and development, methodological and curricular support to teacher educators so that they have research informed resources and curriculum for the integration of mobile applications into their teacher education programs. The specific objectives of the research are: 1) Establish criterion-referenced assessments to judge the educational value of mobile applications, 2) develop resources for teacher educators to help preservice teachers learn about mobile applications and apply it to instructional environments with learners, 3) develop and test research instruments that assess evidence of preservice teachers’ mobile-TPACK development, 4) design and deliver a new “Going Mobile in Teacher Education” open course that aims to develop pre-service teachers’ mobile-TPACK and disseminate the research-informed mobile application curriculum to the interested educators in Europe and around the world. These objectives will be achieved within 4 work packages that investigate Mobile-TPACK as a specialized form of teacher knowledge. The results will contribute to the overall quality of teacher education programs across Europe and better prepare future teachers who will be equipped with necessary knowledge and skills to utilize mobile applications which are the considered as one of the most promising and accelerating ICTs in the near future in Europe and around the world.

Keywords: s213 education,s113 communication networks - media - information society,teacher education,mobile applications,educational technology
The Affective Role of the Teachers in the Information Age Classroom (ARTIAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The suggested project (ARTIAC) will be carried out under the interdisciplinary field of the Learning Sciences, and will use various research methodologies, including state-of-the-art Learning Analytics and Educational Data Mining approaches. Its main purpose is to empirically study the changing role of the teacher in an era where software used in class might be capable of recognizing not only a pupil’s academic level and needs, but also the pupil’s emotional regularities and irregularities. With this kind of information – and as teachers have crucial role in promoting an affective investment on the part of their pupils – it should be examined if teachers are to change the focus of their attention in computer-based classes towards supporting their pupils with meaningful and timely affective support. The project will explore this change of focus, and will supply teachers with efficient technological tools to support them in their affective decision-making in real-time. By its nature – combining concepts, models, and methods from Education, Psychology, Computer Science, Engineering, and others – this project is truly interdisciplinary.

Keywords: learning sciences,computer-based learning,information age,affective feedback,teachers' affective role,learning analytics,educational data mining
Visualizing Functional Structural Dynamics of Membrane Protein Transporters (VISUALTRANSPORT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Membrane protein transporters catalyze fundamental physiological processes in all kingdoms of life. A schematic view of membrane transport is emerging from a growing number of crystal structures. However, several fundamental features of membrane protein transport are still evasive, such as how the protein transition between states, what triggers these structural rearrangements, and how the release of energy is coupled to the transport event. The proposed research will build an interdisciplinary platform, which uses molecular biology, biophysical and computational techniques, to characterize membrane protein transport over the full spatio-temporal scale. Molecular dynamics (MD) simulations will capture high-resolution dynamics on the nano-to-microsecond timescale, which will identify communicative salt-bridge/H-bond networks, putative transport pathways, and the energetics involved in substrate transport. Predictions from the simulations will be verified by in vitro characterization of mutagenic phenotypes. Time-resolved wide-angle X-ray scattering (TR-WAXS) will monitor the micro-to-millisecond, large-scale structural rearrangements, which are out of reach for the MD simulations. The proposed platform for characterization of membrane protein transporters will be developed using a copper-transporting P-type ATPase (CopA) as the initial model system. The P-type ATPase family is divided into types I-V, depending on the transported substrate. CopA is the first crystal structure from the type-I ATPases, making it a particularly exciting model system. The applicants’ preliminary molecular dynamics (MD) simulations and the CopA transmembrane architecture strongly indicate a unique mode of transport in type-I ATPases. Hence, by means of visualization of copper transport, this proposal enables the development of an interdisciplinary European platform for multifaceted characterization of membrane transport that will be extendable to a range of membrane protein targets.

Keywords: membrane protein transporters,structural dynamics,time-resolved wide-angle x-ray scattering,molecular dynamics simulations
Roles of miRNAs in Herpes simplex virus 1 infection (HSVMIR-IJ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Croatia
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Herpes simplex virus 1 (HSV-1) is important human pathogen widely known as the causative agent of cold sores, and it is the leading infectious cause of blindness, and the most common cause of sporadic encephalitis. Although intensively studied, many fundamental aspects of the HSV-1 biology are poorly understood, including the control of latency and regulation of gene expression. We have recently discovered numerous miRNAs, a class of small regulatory non-coding RNAs, expressed by HSV-1 and closely related virus, HSV-2, revealing a new paradigm for the HSV gene regulation. Some of these miRNAs are conserved between these two viruses and expressed differentially during different phases of infection; however function of most HSV miRNAs is unknown. We hypothesize that miRNAs have a central role in modulating the host-pathogen interaction that leads to efficient virus replication and establishment of latency. Also, we hypothesize that miRNA have a central role in establishing the threshold for the reactivation upon different stimuli, i.e. control of the lytic-latent switch. Here we seek to understand the roles of microRNAs (miRNAs), encoded by the virus and host, in the regulation of gene expression during lytic and latent HSV-1 infection. We primarily focus on functions of miR-H1 and miR-H6, HSV-1 miRNAs abundantly expressed during lytic infection, and lytic and latent infection, respectively, and miRNAs almost entirely complementary to each other. In our preliminary data, we have generated the HSV-1 mutant impaired for the expression of these miRNAs and characterize the mutant in vitro and in a mouse model. In addition, to enable high-throughput technologies, we have tested several in vitro latency models and characterized the expression of HSV-1 and host miRNAs in these models. At the conclusions of these studies we will have better understanding of the HSV-1 biology including the virus pathogenesis, and it might lead to novel approaches to cure HSV infections.

Keywords: hsv-1,mirna,pathogenesis,latency,virulence,host factors,new targets
Biomimetic Multibinding Pre-Organocatalysts (BIO PRE-ORGANOCATS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Catalysis is an important field in chemistry because it allows to perform more environmentally and economically sustainable chemical processes. The end of the last century was dominated by the use of metal catalysts, which are expensive and pollutants. In the last decade, a new trend towards using small and relatively simple organic molecules as catalysts has witnessed incredible growth. These organocatalysts have become very popular but there are still several limitations related with their efficiency and selectivity that frustrate their incorporation to industrial processes. The massive screening approach undertaken until our days to solve these limitations has been proved inefficient, so a more rational approach seems necessary. In the last two years, deep mechanistic analyses performed by the coordinator of this proposal and others have shed light over the elements that control the reactivity and selectivity of organocatalytic reactions. The new mechanisms proposed have rationalized strange phenomena previously observed, have put an end to wrong preconceived ideas and have opened a new approach to organocatalysts design. This project intends to take advantage of the new catalytic downstream intermediates that will generate a Curtin–Hammett scenario. Under these conditions, the different thermodynamic stability of the intermediates will determine the reactivity and selectivity of the organocatalysts. This new design strategy is complementary to the classical one, which uses the different kinetic reactivity of a common intermediate as a determining factor. The multibinding organocatalysts will exploit the advantage of the Curtin–Hammett scenario and will benefit from catalytic downstream intermediates. In addition, the design proposed in this project has other advantages, such as the reduction of catalyst deactivation processes by using bio-inspired pre-organocatalysts and the possibility to easily create extensive multicomponent organocatalyst libraries.

Keywords: organocatalysis,reaction mechanism,kinetic studies,curtin-hammett principle,catalyst deactivation,turnover number (ton),turnover frequency (tof),biomimetic.
Yiddish in German: A Cultural History of Translation (YIDDISH IN GERMAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This project explores German translations of Yiddish literature, published in the German-speaking world over the period of five centuries: from the mid-sixteenth century and up to the present day. Although a historical study in nature, the project also makes extensive use of the insights and methodologies developed in the field of Translation Studies over the past few decades. Going beyond a strict linguistic analysis to examine the translated works in their historical backgrounds and ideological frameworks, the project uses the cultural phenomenon of German translations from Yiddish as a window into broader mechanisms in German-Jewish history throughout the early modern and modern periods. The project will focus not only on internal German-Jewish developments, but also on the interactions between Jews and non-Jews in Germany on the one hand, and between the German Jews and their east-European coreligionists on the other hand. By analyzing a large body of translations, and the discourses surrounding them, from the perspective of cultural history, the project seeks to shed light on an important and hitherto under-represented chapter in the history of the Yiddish-German encounter. It thus aims to contribute not only to the field of Yiddish Studies, but first and foremost to those of German and German-Jewish history and culture, which it illuminates from the unique perspective of translation. As the first major attempt to put German translations from Yiddish at the center of a systematic and comprehensive study, and to narrate the cultural history of this important genre, the project also aims to contribute to the emerging field of cultural and social history of translation, and to promote our theoretical understanding of the role of translation in the evolution of cultures and the interactions between them.

Keywords: translation,cultural history,yiddish literature,german history and culture,german-jewish history and culture,yiddish-german encounter,christian-jewish relations,early modern and modern period
Biological production of butanol from syngas (SYNTOBU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The global energy consumption has doubled over the last 30 years, sustained mainly by the use of fossil fuels. The potential depletion of these may leave our society at the edge of an energy crisis unless reliable alternative energy sources are developed. The current context has led to the investigation of alternatives, such as bio-fuels, a renewable energy source with carbon neutral contribution to global warming because they are generated from biomass or wastes. These can be converted to bio-fuels by different ways. One of the most common is the catalytic process Fischer-Tropsch (FT), which allows the conversion of carbon monoxide and hydrogen to liquid hydrocarbons. This process requires an initial stage of gasification to convert the wastes into a mix of CO2, CO and H2 called syngas. This gas contains also impurities (i.e. volatile sulfur compounds, tars, ammonia). The FT process is well established, but is complex and has high energetic requirements. Additionally, the process requires the use of catalysts, of high cost and elevated sensitivity to impurities. To protect them, syngas has to be pre-treated, although this is not always technically possible and economically feasible. Currently, alternatives to the FT process are being investigated. One of them is the production of ethanol and other bio-fuels using microorganisms as biocatalysts. The main advantage of these fermentative processes is the high specificity and yield. They are also conducted at temperatures slightly higher than room temperature, reducing the operational costs. Furthermore, the microorganisms have a high tolerance and adaptability to syngas contamination. The main aim of this project is to investigate the production of butanol from syngas. The study will characterise the process both kinetically and stoichiometrically and identify optimal operational conditions, as well as investigate the production of butanol in continuous mode under different bio-reactor configurations.

Keywords: butanol,syngas,bio-fuels,fermentations,bio-process engineering,microbiology,waste management.