Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INnovation in Truffle cultivation, preservAtion, proCessing and wild truffle resources managemenT (INTACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Spain,Spain,Italy,Spain,Spain,Argentina,Italy,Serbia,France,France,Chile,Morocco
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2022-01-01
End date: 2025-12-31
Duration (months): 48.0
Total project cost (EUR): 1357000.0
EU funding (EUR): 1357000.0
Participants: 18
Project status: SIGNED

Truffles are esteemed edible fungi and one of the most valuable non-wood forest products that grow in symbiotic association with their host trees. They are of high economic and social value and their cultivation is of significant interest in the development of rural areas in European countries, but increasingly also in other continents. However, it has been observed a decline of wild truffle production and a heterogeneity in the truffle yields in new plantations, mainly due to the lack of enough knowledge about the ecology and management of the fungi. Accordingly, this MSCA-RISE project aims at establishing a multi-lateral network of research and innovation staff active in sustainable use of both wild and cultivated truffles, including the cultivation, but also pre-treatment, preservation and processing of the truffles. Particular attention will be paid at issues related to the juridical and normative framework for a traceability legislation for each country involved and to rules on collecting wild truffles in Europe. The research capacities will be strengthened through the exchange of knowledge and expertise on a shared research and training program providing a stronger transnational cooperation and better connections between actors committed to research and production on the truffles value chain. The involvement of Non-Academic Organisations will ease the sharing of knowledge and ideas from research to all levels of the truffle value chain. The joint Intersectoral and Interdisciplinary exchange program will involve 17 Academic and Non-Academic Beneficiaries and Partners and will be performed through a series of short-and long-term periods of staff exchanges. The program will run over 4 years thus allowing the broad portfolio of exchanges to be performed. The planned program of secondments is extensive and involves a range of scientific activities from technical skills exchange and training, to methodological development and planning of future new research.

Keywords: truffles cultivation,wild resources management,identification by morphology,molecular,identification,post harvesting,legal,economics and ethics issues
Impact of extracellular vesicles isolated from seminal plasma upon Assisted Reproductive Technology (oocyte maturation, fertilization and embryo culture) in a mammalian model (SPARTEVs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-11-28
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

This Proposal aims to enhance the current knowledge of seminal extracellular vesicles (EVs) and to evaluate whether they can improve the efficiency of in vitro embryo production (IVP), a technology with a great potential in the biomedical and agricultural field but still inefficient. Inquire the EVs is currently a challenge as they seem to play a vital role in intercellular communication, including embryo development. Knowing that seminal plasma (SP) is beneficial for sperm-oocyte interaction and embryo development and that it contains EVs, our hypothesis is that seminal EVs could play a pivotal role in the successful development of the above cited reproductive events. The experiments will be performed with gametes and porcine SP, as this species is relevant in the agricultural field and is an excellent animal model for exploring human reproductive physiology. The first experiment will focus on developing an efficient procedure to isolate the two EV-subtypes, exosomes and microvesicles, and then analyze their charge in proteins to reveal the specific EV-subtype function. Then, the main objective will be to evaluate the role of each SP-EV-subtype on in vitro oocyte maturation, fertilization and subsequent embryo development. Further, the transcriptomic changes experienced by embryos will be analyzed. The objectives will be reached through a multidisciplinary approach. The Project will be carried out at the University of Bologna, will be supervised by Prof. Tamanini, who has an extensive experience in reproductive biology, and will strength the Applicant’s background. The Proposal represents an innovative challenge for IVP, both for livestock animals and humans, since it tackles the problematic of IVP efficiency from a novel angle. The Proposal has a great potential impact on Society, addressing two H2020-challenges “Health, Demographic Change and Wellbeing” and “Food security; sustainable agriculture and forestry, marine and inland water research and the bioeconomy”.

Keywords: seminal plasma,extracellular vesicles,reproductive biology,assisted reproductive technology
Recycling Environmentally Persistent Fluorocarbons with Metathesis and Shuttle Catalysis (FluoroCycle)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Fluorine containing molecules and materials improve our quality of life. For example, fluorinated gases are used as refrigerants in the automotive sector, while fluorine containing polymers such as Teflon® are common in households. Fluorine is also important for drug discovery and agrochemicals. For all its advantages, the fluorochemicals industry is unsustainable. Nearly all fluorine containing molecules on our planet are synthetic and single use. At the end of their lifetime they are either destroyed or end up contaminating the environment. Environmental contamination has been extremely damaging. Fluorinated molecules have contributed to ozone depletion (chlorofluorocarbons - CFCs), global warming (hydrofluorocarbons - HFCs) and water contamination (polyfluorinated alkyl substances - PFAS). If we are to continue to depend on fluorine containing molecules and materials, then we must find ways to reuse and recycle fluorine containing molecules at the end of their lifetime, we must stop our reliance on unsustainable natural sources of inorganic fluoride, and we must prevent unnecessary contamination of our planet with synthetic fluorine containing molecules. My objective is to develop new catalytic approaches for the recycling of fluorine containing molecules. My long-term vision is to establish new methods in which fluorine containing molecules such as HFOs, HFCs and PFAS can be used as a source of fluorine atoms and fluorine containing groups. I will pioneer new catalytic reactions that involve the exchange of fluorine atoms between two organic molecules and shuttle equivalents of HF and F2 from one organic fragment to another. These methods represent an important step forward to closed-loop recycling in the fluorochemicals industry. The new methods will be showcased in the production of fluorinated electrolytes from HFOs, new materials from HFCs and new fragments for drug-discovery from the recycling of PFAS, including Teflon®.

Keywords: fluorine chemistry,organometallic chemistry,main group chemistry
NOVEL GRAM-NEGATIVE ANTIBIOTIC NOW (GNA NOW)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Germany,Germany,Germany,France,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Intravenous treatments of serious infections (urinary tract infections, intra-abdominal infections & hospital-acquired pneumonia/ventilator associated pneumonia) caused by Gram(-) bacteria (Enterobacteriaceae +/- Pseudomonas and/or Acinetobacter) (H2020-JTI-IMI2-2018-16-single-stage, 2018)
Start date: 2019-07-01
End date: 2025-06-30
Duration (months): 72.0
Total project cost (EUR): 31415987.0
EU funding (EUR): 12299995.0
Participants: 12
Project status: SIGNED

AntiMicrobial Resistance (AMR) is a global and serious threat to human health. Gram-negative bacteria are widely regarded as the culprit representing one of the gravest dangers. Indeed, there is a dearth of new agents able to address AMR in Gram-negative bacteria, especially compounds with novel modes of action. Finding and developing such compounds represents a huge scientific challenge, one that requires the collaboration of stakeholders bringing many different kinds of expertise. The world is coming together to tackle this issue and public-private partnerships represent an attractive way to hasten the pace and increase the probability of successfully identifying and developing novel antibiotics. Under the global umbrella of the AMR Accelerator, the Gram-Negative Antibacterials-NOW (GNA NOW) consortium pledges to a 6-years commitment to bring together key European academic and private experts in antibiotic discovery and development in order to support and manage a portfolio of novel mode of action drugs against Gram-negative bacteria. Starting with three initial compounds/series, dedicated project teams will work together to define and execute the most efficient project plans. The consortium will put in place robust governance and management structures to ensure that the most promising compounds are pursued diligently. Ultimately, the goal of GNA NOW is to progress one compound through completion of phase I studies plus one compound reaching Investigational New Drug (IND) stage and/or up to two compounds reaching clinical development candidate stage.

Keywords: gram negative antibiotics,clinical development candidates
Hybrid EneRgy stOragE Stations (HEROES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Spain,Belgium,Norway,Norway,Denmark,Denmark
Call: Hybridisation of battery systems for stationary energy storage (H2020-LC-BAT-2020, 2020)
Start date: 2021-05-01
End date: 2024-08-31
Duration (months): 40.0
Total project cost (EUR): 4137525.0
EU funding (EUR): 4137525.0
Participants: 10
Project status: SIGNED

Electric vehicles (EV) are expected to play a key role towards a decarbonised transport system and thus contribute to meet EU’s ambitious goal to reduce greenhouse gas (GHG) emissions. However, the wide adoption of EVs has been hampered by key barriers, particularly the lack of a well distributed infrastructure for fast and widespread charging. The main objective of HEROES is the development and demonstration of a disruptive hybrid high power/high energy stationary storage system for fast charging of EVs (23 min) to be used in medium-size charging stations connected to the LV grid. The system will take advantage of combining state-of-the-art Li-ion capacitor (LiC) with high power and high energy densities, with Li-ion batteries (LiBs) to store high amounts of energy and serve as back-up when the charging demand of EVs surpasses the LiC and grid connection capacity. The combination will bring a higher efficiency and better performance of the system, as well as longer battery life, as the LiC can protect the LiB from accelerated degradation, more energy from battery cells, simpler and cheaper management, and lower overall system cost, all with a strong sustainable drive. The HEROES system will be a key enabler for the widespread fast charging of EVs, cost-effectively, without the need for major investments in the grid. To achieve this overall objective, the project will include research and development activities of key technological enablers such as the LiC cells and modules, a new Battery Management System, a DC/DC converter specifically developed for high input and output voltage ranges, and Energy Management System (EMS). The prototype system will be demonstrated for the fast charging of EVs in operational environment. The consortium includes partners that cover the full value chain of energy storage, placing the consortium in a perfect position to develop scientific and technological breakthroughs as well as seizing novel market opportunities.

Keywords: li ion capacitor,super activated carbon,battery management system,energy management system,ev fast charging
Development of an Easy-to-use Metagenomics Platform for Agricultural Science (MetaPlat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Ireland,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 648000.0
EU funding (EUR): 648000.0
Participants: 5
Project status: CLOSED

The aim of this project is to bring together experts from the academic and non-academic sectors and to create an easy-to-use integrated hardware and software platform. This will enable the rapid analysis of large metagenomic datasets. It will provide actionable insights into probiotic supplement usage, methane production and feed conversion efficiency in cattle. In the recent years, the number of projects or studies producing very large quantities of sequencing data – analysing microbial communities make-up and their interactions with the environment – has increased. Yet, the depth of analysis done is very superficial and represents an inefficient use of available information and financial resources. This project aims to address these deficiencies and will study the change within microbial communities, under various conditions in cattle guts and impacting probiotic supplement usage, methane production and feed conversion efficiency in cattle. To succeed, we propose to develop faster and more accurate analytic platforms in order to fully utilise the datasets generated. By focusing on better hardware and software platforms, better expertise and training, this project will pave the way for a more optimal usage of metagenomic datasets, thus reducing the number of animals necessary. This will ensure better and more economic animal welfare. The Meta-Plat project objective is a mixture of innovative research, focused application and commercial awareness. The core objectives being pursued are: • Sample gut collection, from cattle, for sequencing; • Collection of publically available databases – to create a new classification of previously unclassified sequences, using machine learning algorithms; • Development of accurate classification algorithms; • Real-time or time-efficient comparison analyses; • Production of statistical and visual representations, conveying more useful information; • Platform integration; • Provide insights into probiotic supplement usage, methan

Keywords: bioinformatics,metagenomics,microbiome
Optimised Energy Efficient Design Platform for Refurbishment at District Level (OptEEmAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Innovation actions
Countries involved: Spain,Spain,Ireland,Germany,Spain,Spain,Italy,Spain,Greece,Sweden,Türkiye,France
Call: Innovative design tools for refurbishing of buildings at district level (H2020-EeB-2015, 2015)
Start date: 2015-09-01
End date: 2019-02-28
Duration (months): 42.0
Total project cost (EUR): 4748858.75
EU funding (EUR): 4243682.25
Participants: 13
Project status: CLOSED

OptEEmAL aims to develop an Optimised Energy Efficient Design Platform for refurbishment at district level, which will deliver an optimised, integrated and systemic design based on an Integrated Project Delivery (IPD) approach for building and district retrofitting projects, reducing time delivery and uncertainties, resulting in improved solutions when compared to business-as-usual practices. This main objective will be deployed through the following key objectives: 1. Development of a holistic and effective services platform for District Energy Efficient Retrofitting Design integrating interoperable modules and tools able to provide services for diagnosis, scenarios generation (according to stakeholders priorities), energy/ cost/ environment/ social evaluation, scenarios optimisation and data export. 2. Reinforcement of the presence of all involved stakeholders through an Integrated Project Delivery approach that will allow them being articulated through a collaborative and value-based process to deliver high-quality outcomes. 3. Development of an integrated ontology-based District Data Model that will contain key information in the fields of energy, comfort, environment (LCA), economic, social wellbeing and urban morphology. 4. Development of an Energy Conservation Measures catalogue (ECM) including technical, operational, maintenance and cost information giving valuable and consistent outputs to the design and district operation and maintenance stages. 5. Development of a bio-inspired optimization module based on Evolutionary computing with the aim to automate the decision making process to obtain the optimal design for an energy efficient retrofitting plan at district level. 6. Development of external connections of the OptEEmAL Platform to external entities (i.e. existing tools enabling the calculation of indicators to generate and optimise the retrofitting scenarios) 7. Strong disseminations, training, exploitation and market deployment strategies.

Keywords: retrofitting,design,district,energy efficiency,environment,stakeholders,data model,ontology,catalogue,evolutionary computing
EpiShuttle: Isolation and Transportation of Infectious Disease Patients (EpiShuttle 2.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-05-01
End date: 2022-03-31
Duration (months): 35.0
Total project cost (EUR): 3565000.0
EU funding (EUR): 2495500.0
Participants: 2
Project status: CLOSED

The Problem: An increasing number of outbreaks with infectious diseases are seen globally. Ebola has claimed at least 77 lives in DRC (Congo) so far this year and over 11 thousand people West Africa in 2014. Other recent outbreaks are the SARS-epidemic, the MERS-cases in Asia, multi-resistant tuberculosis and the pulmonary Plague epidemic in Madagascar, Zika virus in Brazil, etc. Each of these events demonstrated the large health, economic and security risks associated with infectious disease outbreaks. The travelling patterns of our modern society increases the risk of a global “catastrophe”. To handle outbreaks, the CDC highly recommends the use of specialized isolation units (SIU) to isolate and transport the infected patients. The Solution: EpiGuard was founded in 2015 by a group of medical doctors that faced the challenge of managing Ebola patients on the field. After 3 years and ~5 million EUR of capital and labour investment, the company has recently launched into EU market the EpiShuttle solution – the world-first hard-top (polycarbonate), reusable SIU, representing a leap forward against the state of the art. The EpiShuttle is a one-person SIU, providing complete protection from contagious diseases, without compromising advanced treatment and care to the patient. The Opportunity: Partnering with a world-class design and engineering team, EpiGuard wants to position EpiShuttle as the gold standard for SIUs in the emergency workflow. EpiShuttle targets a 12 Bill. EUR market opportunity worldwide. Although the response from medical professionals has been positive, to fully exploit the market potential, there is a need for combining modern gas disinfection technology with EpiShuttle to allow re-use in a cost effective manner. Further, to expand the market outside Europe, regulatory clearance in USA and China plus a larger size unit for the USA market are needed.

Keywords: preparedness,isolation units,infectious diseases,outbreak,microbial resistance,epidemics,evacuation,repatriation
Selective Modifications of ARomatics through Biocatalytic Oxidations (SMARTBOX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Italy,Germany,Spain,Belgium,Norway,Switzerland,Switzerland,Belgium,Belgium,Netherlands,Portugal
Call: Develop techniques and systems to improve the performance of biocatalysts (H2020-BBI-JTI-2018, 2018)
Start date: 2019-05-01
End date: 2023-10-31
Duration (months): 54.0
Total project cost (EUR): 4520895.83
EU funding (EUR): 3924163.0
Participants: 11
Project status: SIGNED

Although they have the potential to improve the economic and environmental sustainability of biorefineries, oxidative enzymes have not experienced a complete breakthrough yet in the biobased industries. This is mainly caused by the high cost and long time associated with traditional enzyme engineering methods such as directed evolution. SMARTBOX will develop an advanced computational engineering platform specifically for oxidative enzymes, which can automatically screen for improved enzyme variants with minimal human intervention. This is achieved by implementing several innovations into current computational screening methods, most importantly machine learning, which allows to train the algorithms with experimental results. As this significantly improves computational predictability, the time and costs associated with oxidative enzyme engineering will be reduced 10-fold compared to state-of-the-art (SOTA) directed evolution methods. Relying on the advanced engineering platform, SMARTBOX will develop the one-enzyme conversion of HMF into FDCA and intermediates, and the one-enzyme conversion of lignin monomers into a potential biobased building block for polycarbonates and vanillin. By adopting a 1-enzyme FDCA production process, the associated production costs and carbon footprint are expected to decrease significantly compared to SOTA chemical oxidation methods. The unique feature of SMARTBOX is that reductive catalytic fractionation (RCF) will be used to selectively produce specific lignin monomers from biomass in near theoretical yields. The structural similarity of the resulting monomers with the SMARTBOX building blocks allows the development of high-yielding processes with only one enzyme. Due to the smart combination between oxidative biocatalysis and RCF, the production of bio-aromatics will proceed with higher yields than the state of the art.