Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improved metallic GLASses for Small Implants through X-ray and biological characterisation of corrosion products (GLASSIX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Small metal implants such as dental implants or bone-anchored hearing aids need very good mechanical properties and corrosion resistance to avoid local inflammation and remain integrated in bone. In GLASSIX, Ti-based metallic glasses will be developed specifically for small implants using a new approach to evaluate biocompatibility. This is usually tested on passive metal surfaces, but recent work has shown that mechanically-assisted crevice corrosion (MACC) can generate metal particles and corrosion products that damage the surrounding tissue. In situ characterisation of corrosion products with synchrotron X-rays will be used to design standard simulated corrosion products that will then be tested on human cells to evaluate which corrosion products are most damaging. The findings from this new approach will be fed back into the alloy development process together with information on feasibility of manufacture from Anthogyr, a leading manufacturer. The project combines the ER’s expertise in metallic glasses, and the expertise of host researchers in corrosion, X-ray methods, clinical and biomedical research, and will equip the ER to carry out cutting edge research in an academic environment that can readily be translated into clinical and commercial success in the biomedical devices sector.

Keywords: metallic glasses,biomaterials,pitting,mechanically assisted crevice corrosion,synchrotron x ray methods
Solutions @ Underwater Radiated Noise (SATURN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Germany,Italy,Spain,Italy,Spain,Ireland,Norway,France,France,France,France,Netherlands,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom
Call: Under water noise mitigation and environmental impact (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2021-02-01
End date: 2025-01-31
Duration (months): 48.0
Total project cost (EUR): 8965963.75
EU funding (EUR): 8965963.75
Participants: 20
Project status: SIGNED

The SATURN consortium brings together leading experts in bioacoustics; population biology; marine mammal, fish and invertebrate biology; maritime architecture and engineering; shipping; maritime policy; stakeholder engagement and science communication. We will combine expertise from these disciplines to work with unity of purpose and clarity of intent to identify: a. The sounds that are most detrimental to aquatic species and how they are produced and propagated; b. The short-term and cumulative long-term negative impacts of noise from shipping and boats on three representative groups of aquatic species in rivers and the sea (invertebrates, fish and marine mammals); c. The most promising options for measuring and reducing the negative impacts of ship noise that can be applied to current and future vessels. SATURN will develop and contribute to the establishment of standards for terminology and methodology to be used across all disciplines working on underwater radiated noise. These standards will underpin the proposed research. The consortium will establish and nurture an effective community of researchers, practitioners, competent authorities, maritime operators, shipping/offshore/naval industries, and NGOs. This group will work closely with the project to ensure that outputs are tailored to the needs of all stakeholders and to maximize their uptake and application. SATURN proposes to confront the complex global issue of underwater radiated noise in a truly inclusive, transdisciplinary way that will ensure that the interests and knowledge of all stakeholders and the environment are represented.

Keywords: underwater noise,anthropogenic noise,shipping,ship noise,mitigation,impacts,standards
Integration of RNA Biology for Next-Generation Scientists (INTEG-RNA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Czechia,United Kingdom
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 899985.0
EU funding (EUR): 899985.0
Participants: 5
Project status: SIGNED

While there are ever-increasing interconnections and integration across CEITEC MU research programs as well as across different scientific fields in nearby faculties, most of the research is still performed within the boundaries of individual laboratories or research programmes. The CEITEC groups involved in this proposal have diverse research interests however they are all connected by the same fiber- RNA. The overarching aim of this project proposal is integration of these groups at the level of methodological approaches, research questions and training of young scientists. In addition, empowering excellence in science and training, research management and boosting institutional recognition will position CEITEC MU as an RNA excellent research cluster. We plan to achieve our aims through close collaborations in joint research, increased mobility of researchers, ESRs and research management staff and increase the impact through dissemination of the results at a local, national and international level. The Twinning partnerships will help create a synergistic environment enabling CEITEC MU to have the confidence and expertise to establish an excellence RNA cluster with a Europe-wide network and competitive technologies, while heading for the future of excellence.

Keywords: rna biology,bioinformatics,knowledge transfer,scientific mobility,cross disciplinary collaboration,data analysis
ATR-mediated mechanotransduction and connections with the actin cytoskeleton (MECHANOCHECK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

The ATR protein kinase controls the DNA damage response (DDR), with ATM, Chk1 and Chk2. DDR genes are often mutated in cancer cells and act as an anti-cancer barrier in response to oncogenic stimuli. ATR is essential and protects the integrity of replicating chromosomes, prevents fragile site expression and aberrant condensation events. The Foiani laboratory recently found that ATR associates with the nuclear envelope during S phase and prophase and in response to osmotic or mechanical stress. Moreover, ATR-defective cells exhibit aberrant chromatin condensation and nuclear envelope breakdown. These observations prompted us to suggest that the ATR-mediated mechanical response enables cells to cope with the mechanical stress induced by topological transitions through the modulation of nuclear plasticity and chromatin association to the nuclear envelope. However, the molecular mechanism and functional relevance of ATR-mediated mechanical response remain unclear. Mechanosensing occurs primarily through the actin cytoskeleton, which forms the cellular mechanical system linking the extracellular microenvironment to the nucleus. We aim at understanding the connections between the ATR-mediated mechanotransduction pathway and actin modulation in response to mechanical stress. Our working hypothesis is that ATR may be part of an integrated response to mechanical stress that has a more general role in controlling cell and nuclear plasticity through the modulation of actin cytoskeleton and nuclear events. To address these questions, we will employ and develop various multidisciplinary approaches including state-of-the-art Atomic Force Microscopy (AFM), micropatterned protein substrate, novel microfluidic device and accompanied with advanced molecular biology techniques in order to quantitatively and systematically explore the ATR mediated mechanotransduction.

Keywords: dna damage response,mechanotransduction,genome instability
Novel radioactive radiation technology feasibility verification (Radiation detector)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-09-30
Duration (months): 7.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sensinite develops and manufactures nuclear radiation detection technology revolutionizing the usability and application locations of the radiation detectors. With the Sensinite detection technology illicit nuclear material trafficking will be harder and the Europe will be safer from terrorist attacks. The border security of Europe will improve drastically, allowing even 25x higher number of inspected sea containers. Company's clients are manufacturing partners integrating technology of the company to their own end products. The company expects of achieving sales of 35 million EUR by 2023. This grant applied is to fund the study of commercial and technological feasibility.

Keywords: nuclear,radiation,border security,counter terrorism,internal security,new solution
Directed and three-dimensional placement of continuous fibres with the direction of forces enabling a significant reduction of costs and weight in carbon fibre components (3D-Roving Deposition)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-09-01
End date: 2018-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Following the trends towards energy and resource efficiency, lightweight construction is more and more in the focus of attention, especially in the automotive, aerospace and engineering markets. The main problem, however, is the still existing stress ratio between costs, weight and strength of the components. While a standardised production of simple composites is already possible, the manufacturing of highly stressed structural components based on carbon fibre reinforced plastics, which are becoming more and more market relevant, still poses a major challenge. Although it is possible to manufacture composites that show high specific strength and stiffness, this is linked to very high production costs and so far only possible for unidirectional fibres. However, for most structural components this is not sufficient, requiring the specific use of reinforcements or additional fibre systems. This is mostly related to additional manual work, leading to both, lower production speed and higher overall costs. KEIM has developed a prototype for the three-dimensional placement of fibres in the direction of the force for the creation of the preform that is then finalised by using the hot-RTM process. The prototype is based on a robot that uses previously determined measurement data to perfectly place the fibres with regards to material usage, weight and stiffness, creating a three-dimensional preform with perfect properties. This preform is then introduced into the hot-RTM process in order to create highly stressed structural components. The functionality has already been tested thoroughly and demonstrated in an industrial environment. In addition, the process has been patented, securing the freedom to operate. In the feasibility study, the economic and technical validation of prototype and business planned will be performed, verifying the best-suited applications and key markets for the initial market introduction of this very innovative process.

Keywords: fibre,placement,cfrp,carbon,production,process,force,strength,stress,components,robot,lightweight,resin,preform
Investigating the recognition of a novel ligand by gamma-delta T cells and the translation of this interaction into molecules for future cancer immunotherapy (gdTCR-Ligand)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Gamma-delta (gd-)T cells are a fast acting subset of T cells that recognize a wide variety of ligands. In contrast to alpha-beta T cells they are not restricted to classical peptide-MHC antigens. Our preliminary data on a gd-T cell clone shows selective recognition of tumour cells mediated through a novel ligand. The aims of this action are; 1) elucidating the molecular mechanism of the gd-T cell receptor (TCR) recognizing the novel ligand on cancer cells and 2) generating therapeutic agents for cancer cells. A multidisciplinary approach will be used to unveil the interaction of the gd-TCR with its ligand. The gd-TCR and novel ligand molecules will be made using recombinant expression. These proteins will be used to characterize this interaction in detail by determining the affinity and the crystal structure. The results generated in this part of the action will increase the current knowledge regarding gd-T cell ligands. The researcher will reintegrate in his home country using his skills in structural immunology, which he acquired in the Rossjohn laboratory at Monash University in Australia, to address the molecular mechanism of the gd-TCR ligand interaction. Additionally, he will be trained by the host laboratory in in vitro and in vivo immunological assays.
Fitting-to-Outcome eXpert for semi-automated cochlear implant fine-tuning (Fox-IT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Belgium
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For many deaf patients cochlear implantation has become the standard state-of-the-art care. To achieve optimal hearing performance, cochlear implants need to be adjusted to the individual needs of the user. To date, this has to be done manually by an experienced audiologist. It involves a complex procedure requiring many hours of work in multiple sessions. Our innovation consists in creating a new semi-automated fine-tuning method by using powerful methods from artificial intelligence. To do so, the implant behavior in response to speech sounds was first modeled mathematically, and subsequently, artificial intelligence algorithms and networks were written and validated. Our new fine-tuning method is groundbreaking in that provides systematics, eradicates unjustifiable variation, reaches preset targets and requires only minimal intervention from an audiologist. Being clinically validated, the prototype of FOX Fitting-to-Outcome eXpert is ready for demonstration in cochlear implant centers worldwide. It is also a first and crucial step in the introduction of eHealth in the field of audiology, empowering patients to take up an active role in the frequency and the way in which their implant is adjusted. For developing countries, it paves the way to bringing modern hearing rehabilitation to otherwise underserved areas. FOX is the result of a strong academic-industrial research partnership over the past few years. The solid scientific base of the new fine-tuning method will create the necessary trust and credibility towards audiological centers, cochlear implant manufacturers and patients. During this Phase 1 project Otoconsult NV intends to assess the technological and market-economic viability of FOX as well as its acceptance by the targeted purchasers and end-users. Part of the tasks will be subcontracted to Flanders Inshape, a competence center of the Antwerp University Management School, bringing in the necessary knowledge and expertise on business innovation.

Keywords: automated fitting,cochlear implant programming,artificial intelligence,hearing rehabilitation,e health,audiology
An Air Quality Monitoring Station in a Chip (InAir)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Air Pollution is the world’s worst environmental health risk: 8.8 million people die every year as a result of air pollution exposure. Consequently, increasingly stringent legislations on air quality (AQ) are being implemented worldwide. To enforce these policies reliable AQ must be monitored. There is an urgent need to bring to the market devices that can complement current air quality monitoring stations delivering equally accurate data and covering a much wider territory. Low-cost air pollution sensors are expected to become a game changer in monitoring pollution. The business opportunity is huge: the overall environmental sensor market is projected to reach €1.93 billion by 2023. At Insplorion, an innovative Swedish company, we have developed and patented a new sensor technology based on our Nano Plasmonic Sensing platform (NPS), which enables us to overcome the shortcomings associated with current low-cost sensors such as low sensitivity and instability. InAir is a revolutionary miniaturized and multiplexed portable gas sensor optimised for highly selective and sensitive detection of the most relevant urban air pollutants: NOx, CO, SO2 and O3. In addition, its miniaturisation and easiness of integration into any device, opens up several business opportunities in the field of AQ monitoring, beyond the field of urban air pollution. InAir is the answer to the urgently needed breakthroughs in AQ sensor technology. It will empower public authorities by providing them with real-time reliable AQ data covering a wide territory, enabling the analysis of air pollution sources and the implementation of air pollution abatement measures. InAir will boost the growth of Insplorion with revenues surpassing the €39 million in the 5th year after market uptake and the creation of more than 20 new positions mostly in the R&D, up-scaling, international sales and financial departments.

Keywords: gas sensors,air pollution,multiplexing,low cost sensors,plasmonics
Active Matter: From Fundamental Science to Technological Applications (ActiveMatter)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Germany,Italy,Germany,Switzerland,Switzerland,Türkiye,Türkiye,Sweden,France,France,United States,United Kingdom,United Kingdom,United Kingdom,Portugal,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 4012080.12
EU funding (EUR): 4012080.12
Participants: 22
Project status: SIGNED

During the last decade, active matter has been attracting increasing interest because its study can shed light on far-from- equilibrium physics and provide tantalizing options to perform tasks not easily achievable with other available techniques on the micro- and nanoscale. We are now on the threshold of breakthroughs that will permit us to gain a deeper understanding of the fundamental challenges associated with far-from-equilibrium physics (e.g. the physics of living organisms, tissue formation and cancer growth) and to address several key technological challenges of great societal and economic impact (e.g. biomimetic materials, targeted localization, pick-up and transport of nanoscopic cargoes in drug delivery, bioremediation and chemical sensing). However, there are still several open challenges that need to be addressed in order to achieve the full scientific and technological potential of active matter in real-life settings: 1. to develop biocompatible active particles, reducing their footprint by scaling them down towards the nanoscale; 2. to determine their emergent and synergistic behaviors in complex and crowded environments; 3. to engineer self-assembly in dense active and living matter systems. This ETN will provide the necessary infrastructure to train a new generation of physicists in the highly interdisciplinary fields related to active matter. ESRs will master the theoretical, numerical and experimental tools currently employed in the study of active matter, will create new tools for understanding active matter systems, and, through collaboration with companies, will be able to transfer this knowledge to biomedical, bioremediation and sustainability applications. Our ESRs will acquire highly demanded transferable skills increasing their future employability in academia and industry. Extending the reach of this ETN, we will also prepare interdisciplinary and interactive lecturing material to serve as foundation for study programs in active matter.

Keywords: active matter,active brownian particles,physics far from equilibrium