Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
In vivo analysis of neuromuscular junction stability in zebrafish models of amyotrophic lateral sclerosis (NMJALS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-16
End date: 2018-03-07
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Amyotrophic lateral sclerosis (ALS) is a late onset, lethal neurodegenerative disease of motor neurons that affects about 2 in 100,000 individuals per year. Different genetic mutations have been described in patients, but the genes involved seem unrelated and the causes of the disease appear complex and are still largely not understood. Of relevance, the destabilisation of neuromuscular junctions (NMJ) may be an early event, preceding neuronal death, making them an interesting therapeutic target to slow down disease progression. The goal of the study is to characterise the molecular organisation and dynamics of NMJ, in particular of cell adhesion molecules, in order to understand the mechanisms of maintenance of NMJ by analysing defects in their organisation in ALS contexts. Technically, we plan to combine neuron biology, quantitative cell biology and computational tools to reach a precise molecular understanding of the dynamic equilibrium of NMJ in zebrafish, an excellent vertebrate model for live imaging. We will develop innovative methods of super-resolution microscopy and of quantification of protein turnover using a fluorescent molecular clock. This precise molecular characterisation of the NMJ will allow detecting subtle early changes in the NMJ that occur before neuronal degeneration starts, in fish carrying mutations described in ALS patients. The project will lead to the identification of key proteins for NMJ stabilisation and enable the analysis of regulatory elements of this stability, especially the cytoskeleton. The innovative multidisciplinary approach of this study will unravel early modifications in the organisation of the NMJ preceding neuronal degeneration in ALS contexts. It will point out key proteins of NMJ maintenance constituting new targets for the development of therapies to counteract destabilisation of neuromuscular junctions, regardless of the genetic specificity of the patient.

Keywords: neuromuscular junction,neurodegeneration,cytoskeleton,zebrafish
QTrobot Autism Therapy Store (QTrobot)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Luxembourg
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-10-01
End date: 2019-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Social robots are effective tools to make healthcare and education more accessible and affordable through standardization and mass replication.Today however working with robots requires extensive IT knowledge. Our vision is to bring social robots for healthcare and education from research centers to mass market by developing user-friendly robots which are accessible for everybody to script custom robot applications. Autism spectrum disorder (ASD) is a neurodevelopmental disorder. It costs £32 billion per year in the UK and greater than the cost of cancer, stroke and heart disease combined. The average lifetime saving of early and intensive behavioral intervention ranges from $1.6 to $2.8 million per child. This requires 20 to 40 hours of one-to-one therapy per week, costing $40,000 to 80,000 per year. The issue in USA is that while the healthcare systems pay for such therapies, there is a lack of therapists. In EU, the situation is worse as there is a tremendous lack of therapists, costs are not covered by health care systems and children receive insufficient number of hours or no therapy at all. We propose an open innovation to offer a holistic solution to make autism therapy accessible and affordable by providing a social robot platform to create, exchange, personalize, utilize and rate therapeutic robot applications by autism therapists and care providers with no IT background. An effective robotic platform for autism has to provide a large amount of various types of content and applications to meet the needs of different individuals. We make the creation of such platform and scaling it in Europe with its multi-cultrual and multi-lingual nature practical and economical through enabling user generated robot therapies to be adapted and re-used by others. This is where the economy of scale has to come from to build an app store of social robot therapies built by psychologists.

Keywords: social robots,autism
Prediction and optimisation platform for the mobile assets management (OMNISCIENT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: France
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Everysens, a French SME company, expert in IoT and Software as a Service (SaaS) solutions for the traceability and logistic sectors, proposes the next generation of intelligent based tracking solution for the market niches that face the challenges of mobile assets management. More precisely, this project targets business holding or renting high-value assets (such as construction and public work equipment, dumpster of waste) and transport and logistic companies (e.g. rail freight logistics). Today, most mobile tracking systems are addressed to motorised mobile assets and do not have enough autonomy to operate on non-motorised items (as wagons or dumpsters). They ensure a so called “continuous” tracking which practically is limited to sending periodic alerts with no real-time tracking and are not based on intelligent analysis and statistics that allows forecasting. Besides, current technologies experiment from inefficient data transmission, coverage challenges in remote areas and high energy consumption for the sensors. Everysens will offer them OMNISCIENT, a prediction SaaS platform based on bespoke artificial intelligence, not only for inventory but also to allow the real-time mobile asset localisation, management and accurate forecasting and planning to enhance operational efficiency of our clients and increase their revenues. Our technology presents a data transmission reliability of 98% and its modular structure allows to easily apply different business rules for different market applications. In this way, our customers will be able to contribute to European Initiatives to improve railway competitiveness such as the “Shift2Rail Joint Undertaking (S2R JU) initiative” or the Waste Directive Framework to build-up the traceability capacity along the recycling value chain. With the commercialization of OMNISICIENT, Everysens expects €10.3 million of accumulated revenues in 2024, which will require to dimension the company structure with 40 additional employees.

Keywords: tracking,traceability,monitoring,mobile assets,transport,railway,logistics,waste management,dumpsters,heavy equipment,assets management,planning,forecasting,intelligent platform,internet
Research and Innovation Centre on Advanced Industrial Production (RICAIP)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Czechia,Czechia
Call: Teaming Phase 1 (H2020-WIDESPREAD-04-2017-TeamingPhase1, 2017)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 399500.0
EU funding (EUR): 399500.0
Participants: 4
Project status: CLOSED

The project RICAIP develops the fundamental for establishing the Research and Innovation Centre on Advanced Industrial Production by leading research organizations from the Czech Republic: Czech Institute of Informatics, Robotics and Cybernetics at Czech Technical University, and Central European Institute of Technology at Brno University of Technology, in strong partnership with prominent German research organizations: German Research Center for Artificial Intelligence and Center for Mechatronics and Automation Technology. The partnership will result in transferring knowledge and expertise from the German to Czech partners, as well as strategic long-term collaboration at all the levels of research, education, and innovation. This will guarantee the unique position of the Center within the European Research Area as a leader in the research field of advanced industrial production. The RICAIP Center will accommodate new areas of research and innovation in the field of Industry 4.0, namely multi-site production and production system development. The Centre will provide a distributed, but virtually integrated experimental testbed. It will be physically based on research facilities of the Czech partners, complemented by a corresponding remote site jointly operated by the German partners. The project’s ambition is to establish an international hub for Industry 4.0 bringing new smart, safe and sophisticated solutions for industrial multi-site production of the future. This project, however, goes beyond the state-of-the-art reference models of Industry 4.0 as it introduces a brand new dimension of the initiative - multi-site industrial production and production development, both with strong impact on society. The long-term vision is to transform the RICAIP testbed into a European Research Infrastructure in the field of Industry 4.0.

Keywords: indsutry 4 0,multi site industrial production,cyber physical system,complex system,data and knowledge representation,automative control,planning and scheduling,collaborative robotics
Transforming Unsustainable management of soils in key agricultural systems in EU and China. Developing an integrated platform of alternatives to reverse soil degradation. (TUdi)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Spain,Spain,Bulgaria,China,New Zealand,Hungary,Czechia,United Kingdom
Call: Healthy soils for healthy food production (H2020-SFS-2020-2, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 5906545.64
EU funding (EUR): 4978240.52
Participants: 15
Project status: SIGNED

TUdi is conceived as a transformative project, integrating 15 academic and SME partners, to develop, upscale and disseminate soil restoring strategies in three major agricultural systems (cereal based rotations, tree crops and grasslands), different farm typologies and environmental conditions in Europe, China and New Zealand. Aimed to lead the way in improving soil health across EU, China and New Zealand, it rests on two pillars: 1) a network of 42 cooperating stakeholder organisations for defining, implementing and upscaling soil restoring strategies in multiple farms; b) a network of 66 long-term experiments and monitored farms in the participating countries. From them, TUdi will identify soil degradation situations, proven strategies for restoring soil health, and barriers and possibilities for its adoption at farm level, including gender dimensions. This bottom-up approach will develop a set of digital tools, compatible with platforms for optimizing CAP implementation in Europe, to predict the impact of these strategies on nutrient and water balance, yield, cost-benefit and farm operations. They will guide farmers in implementing strategies to restore soil health by overcoming barriers for adoption, with rigorous cost-benefit analyses central to farmer appraisal. Solutions will be scaled up over a large number of farms through partners engaged in the cooperators network, including training of stakeholders, developing technical materials and elaborating policy briefs. It will be complemented by communicating project challenges and results to society, raising awareness of the relevance of healthy soils for sustainable development. Providing a blueprint for development and dissemination of soil restoring strategies at large scale, it will contribute to key initiatives like the EU and China Research Agenda for Agriculture and EU Mission on Soil Heath and Food. Training farmers, staff and early career scientists in sustainable soil use will result in lasting legacy.

Keywords: integrated platform,stakeholders,cooperators,soil healing strategies,farm planning development tools,cereal based rotations,grasslands,tree crops
TArgeting Platelet Adhesion receptors in thrombosiS (TAPAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Germany,Germany,Germany,Ireland,Croatia,Hungary,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 3881891.88
EU funding (EUR): 3881891.88
Participants: 13
Project status: CLOSED

TAPAS will position Europe at the forefront of innovative research to prevent thrombosis and thromboinflammation, and will train a uniquely-qualified cohort of ESRs in a highly intersectorial and multi-disciplinary programme that will equip them with the knowledge and transferable skills required in the broad biomedical sector. The research will focus on platelets which are small cells in the blood that play a critical role in prevention of excessive bleeding following injury (haemostasis). Activation of platelets in diseased vessels gives rise to thrombotic disorders such as heart attack and stroke, two of the major causes of morbidity and mortality. Patients at risk of thrombosis are treated with medicines that inhibit platelets for life, but many patients still undergo thrombotic episodes or encounter serious bleeds through diminished haemostasis. There is thus an urgent need for novel and safe anti-platelet medicines that powerfully target thrombosis but preserve haemostasis. In TAPAS, an original and innovative approach will be undertaken to find new ways to target thrombosis through co-operation of academic experts in distinct disciplines with key skills from the private sector. TAPAS will generate and integrate knowledge from analytical complex ‘omics’, advanced microscopy, cell biology, microfluidics, in vivo models, contemporary systems biology and high throughput screens to identify new targets for therapeutic intervention and novel lead compounds or biologics. The research skills developed in this programme are applicable to other complex diseases and represent essential training in modern day research for the next cohort of academic and private sector scientists that are able to convert complex biological understanding into new medicines. The shared knowledge and close interaction between beneficiaries and partners makes this programme ideally suited to an EJD and will deliver 15 ESRs in 21st century biomedical research.

Keywords: platelets,thrombosis,adhesion receptors,anti platelet drugs,super resolution microscopy
Cultural Heritage and Identities of Europe's Future (CHIEF)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Germany,Spain,India,Türkiye,Croatia,Slovakia,Georgia,Latvia,United Kingdom,United Kingdom,United Kingdom
Call: Cultural literacy of young generations in Europe (H2020-SC6-CULT-COOP-2017-two-stage, 2017)
Start date: 2018-05-01
End date: 2021-10-31
Duration (months): 42.0
Total project cost (EUR): 4580371.25
EU funding (EUR): 4580371.25
Participants: 11
Project status: CLOSED

Today, the twinned ideas of respect towards minorities’ rights and cultural diversity that have been projected as values derived from the European historical experience are facing well-documented challenges. These include: the current radicalisation of young people in Europe; processes questioning the meaningfulness of the European project; and the revival of tribal identities and separatism. These processes give cause to fundamentally rethink the idea of Europeanness as a culture of dialogue and mutual respect. CHIEF aims to build an effective dialogue between different stakeholders in order to facilitate a future of Europe based on more inclusive notions of cultural heritage and identity. The project is innovative in its approach to cultural literacy of young Europeans by privileging the importance of production and transition of cultural knowledge in both formal educational settings initiated from above, and a variety of informal human interactions. These informal interactions are often overlooked despite their strong influence on how knowledge about European culture is acquired by young people. The project proposes to explore them by building an inter-disciplinary, multi-sectoral and transnational partnership in nine countries in and outside the EU. Through its research activities and social interventions, CHIEF will have a substantial impact on policies and practices facilitating intercultural dialogue in Europe. It will contribute to understanding and enhancing cultural literacy for young people, resulting in greater appreciation of diversity. The project will lead to more effective use of European cultural heritage as a site of production, translation and exchange of heterogeneous cultural knowledge. Moreover, it will help to recognize existing innovative practices and develop a new organisational model to enhance cultural and inter-cultural competence of young Europeans. Finally, it will empower and bolster the innovative capacities of its beneficiaries.

Keywords: cultural identity,european cultural heritage,young people,formal education,cultural and education policy,cultural literacy
Tropical cyclones generated by tropical transition over the North Atlantic Ocean and their potential hazards for Europe (EuTropRisk)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-02-28
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

During the last 15 years, the eastern North Atlantic has witnessed anomalous tropical cyclones (TCs) generated by the tropical transition (TT) process, some of them affecting or threatening European regions, causing societal damage and public concern. TT is a recently detected TC formation process by which a baroclinically formed extratropical cyclone evolves into a system with a full TC structure. It is also this type of TCs that has the highest likelihood of affecting Europe because they form in midlatitudes. Understanding the TT phenomenon is thus important for weather forecast and informing the public, and researching its link with anthropogenic climate change (ACC) could aid in future mitigation strategy, both with socioeconomical benefits. Recent studies indicated a potential increase of ex-TCs affecting Europe, i.e. of TCs forming via the typical non-TT mechanism and transitioning into extratropical cyclones. However, these studies did not address the TT pathway. Considering the TT process provides a more reliable assessment of the risk of TCs affecting Europe. In addition, newly developed high-resolution global climate models (GCMs) are now potentially capable of simulating TTs. Thus, in order to fill the important knowledge gap about TCs affecting Europe, this project aims to (1) better characterize the development of TTs over the North Atlantic, their predictability and their relationship with midlatitude dynamics, (2) study the representation of TTs in state-of-the-art GCMs, and finally (3) assess the relationship between ACC and TTs, with special focus on Europe. This project is original as it uses new tools and simulations and deals with specific aspects of North Atlantic TCs that have not been addressed before. These aspects are likely highly important for providing the best possible service to society related to weather and climate predictions.

Keywords: tropical cyclones,climate change,tropical transitions,extratropical cyclones,convection,pv dynamics,global climate modelling,pv streamers
Optimizing treatment of cancer patients infected with COVID-19 and other preconditions using mathematical modelling (CancerCOtreat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Cyprus,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 256236.48
EU funding (EUR): 256236.48
Participants: 2
Project status: SIGNED

Cancer patients are of high risk to develop severe COVID-19, which has a negative impact on their clinical management. Cancer therapy and COVID-19 severity can be also affected negatively by preconditions, including obesity, diabetes, hypertension and advanced age, as well as by the gender. To help cancer patients suffering from COVID-19 and the other preconditions as soon as possible, it will be necessary to repurpose existing and well tolerated drugs - alone or in combination. To accelerate this process, we propose to develop an in silico systems biology approach to model the known biology of SARS-CoV-2 infection and the action of approved drugs overlaid on the underlying pathophysiology of cancer patients with different disease states, preconditions and gender. The proposed mathematical framework will mechanistically model the COVID-19 progression in the context of cancer. We will also simulate the effect of COVID-19 in this patient population and explore the efficacy of various treatment regimens to identify synergistic combinations as well as optimal schedules for therapy. Robust model validation will be performed using data from the Massachusetts General Hospital patient database (host of outgoing phase). This is a very timely research because the proposed mechanism-based model will reveal novel strategies to optimally combine current and emerging treatments for COVID-19 in cancer. Importantly, the proposed model will not be limited to COVID-19 but it will set a mathematical framework for the optimal treatment of cancer patients contracted by any infectious diseases. The fellowship will allow the applicant to substantially built upon his previous experience and strengthen his overall scientific abilities. In particular, he will expand his knowledge in tumor/virus biology, cancer research and clinical translation, will enrich his mathematical modelling capabilities and the analysis of complex biological systems that involve more than one medical conditions.

Keywords: mathematical modeling,cancer research,covid 19,tumor,virus biology