Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Immigrant-native health disparities in ageing societies: an intersectional approach (MigHealthGaps)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1499616.0
EU funding (EUR): 1499616.0
Participants: 1
Project status: SIGNED

Immigrants arrive to receiving countries in excellent health. Yet compared to natives their health deteriorates more rapidly. Why this is the case remains poorly understood due to the scarce availability of large longitudinal datasets useful to explain the dynamic of immigrants’ health over the life-course. In the near future, the immigrant-native health gap is likely to be further exacerbated by population ageing. In order to formulate effective policies to reduce immigrant-native health gaps, we need a deeper understanding of the causes of the unhealthy ageing of immigrants. MigHealthGaps undertakes the most comprehensive analysis to date into the study of immigrant-native health disparities. MigHealthGaps has three main research objectives: (1) to quantify the gaps in healthy ageing trajectories between immigrants and natives by age, gender, and socioeconomic status, and their interactions; (2) to determine the impacts of family composition and family ties in generating these gaps; (3) to identify the critical events and circumstances in immigrant lives that put them on a different healthy ageing trajectory from natives. MigHealthGaps addresses these objectives in a comparative and multidisciplinary framework, combining longitudinal survey data with large sample sizes from several European countries, and registry data from the Nordic countries, including the total population. It applies cutting-edge statistical methods to assess the causality between the above-mentioned mechanisms and the immigrant-native health gaps over age. The working-age population – including working age immigrants – will soon enter ages at which the risk of developing health frailties will be higher. Addressing these key objectives is crucial to formulate effective policies to prevent immigrants’ health excessive deterioration, and to make tangible improvements in the process of integrating immigrants into the receiving societies.

Keywords: migrant health,ageing,intersectionality
From antiquity to community: rethinking classical heritage through citizen humanities (AntCom)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark,Italy,Spain
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2027-03-31
Duration (months): 51.0
Total project cost (EUR): 2699028.0
EU funding (EUR): 2699028.0
Participants: 12
Project status: SIGNED

What is the role of classical heritage in building modern, plural, diverse European identities? To answer this question the consortium From antiquity to community: rethinking classical heritage through citizen humanities (acronym AntCom) will train a new generation of 10 highly skilled cultural heritage researchers equipping them to harness the potential of the digital transition as well as to address the professional and societal challenges that it entails. AntCom prioritizes both open science (Citizen Humanities) and innovative curatorial techniques (Multi- and Hyperspectral Imaging) to create an empowering exchange between researchers and communities. Professionals trained by AntCom will have the skills to restitute heritage back to communities and build more complete, sustainable narratives and memory practices about Europe’s classical past. AntCom builds on a high-level, integrated cooperation between the humanities and STEM, inspired by the notion that both areas equally provide skills suitable to meet current needs of the job market and to create a better, more resilient society. AntCom offers the first structured training program in Citizen Science for the humanities (Citizen Humanities). AntCom will forge a cohort of early-stage researchers equipped to design, implement and manage open-science projects, building on advanced techniques of digitization and data collection. AntCom looks at both tangible and intangible classical heritage in Europe within three main areas: 1. Manuscript heritage; 2. Linguistic heritage; 3. Ritual and narrative heritage. A consortium of 4 universities – University of Southern Denmark, University of Verona, University of Salento, and University of Santiago de Compostela – and 8 associated partners, AntCom will provide fellows with the skills and training to lead heritage research in Europe and to be employable in curatorial institutions, science communication, industrial imaging and tourism.

Keywords: citizen humanities,digital transition,public engagement
Integrated, interoperable, smart and user-centred building automation and control system for better energy performance of non-residential historic buildings coupling physics & data-based approaches (SMARTeeSTORY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Italy,Spain,Netherlands,Latvia,Greece,Germany
Call: Smarter buildings for better energy performance (HORIZON-CL5-2022-D4-01, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 6194517.5
EU funding (EUR): 5148296.0
Participants: 13
Project status: SIGNED

SMARTeeSTORY will propose an integrated building automation and control systems for monitoring and optimizing building energy performance according to an innovative multi-domain approach (integrating SRI domains: HVAC, Dynamic Façade, Lighting, EV), incorporating historical building requirements as well as human requirements by envisaging real-time and active user engagement. SMARTeeSTORY system will automatically detect (interacting with users via specific technologies identified in project early stages, e.g. smart home systems) the building users archetypes (via DRL algorithms) therefore specific preferences (SMARTeeSTORY database of users’ archetypes and preferences in smart buildings – energy demand, comfort, etc.) informing the optimization and control services. Such a system will encompass interoperable and cyber-secure software (cloud-based middleware provided with multiple services for: monitoring & digital twin, analysis and prediction, optimization and control, embedding physics and data-based models for forecasting building energy performance and using Digital Building Logbook as a Common Data Environment) and hardware (advanced edge computers, multi-protocols data gateways, smart and automated sun blinds, smart sensors and actuators for Technical Building Systems integrated control according to occupancy and energy efficiency needs, smart products for user engagement) solutions fully enabling the three functionalities required for a building to become “smart”: i) optimization of operation of technical building systems, ii) adapting to the external environment (including energy grids), changing condition in relation to demands from building occupants. The system will be deployed at TRL 8 in three demo sites (non-residential historic buildings) identified in Latvia, Spain and The Netherlands to demonstrate buildings improved energy performance in correlation to the increased smartness rating.

Keywords: historical buildings,digitalization,interoperability,optimization,model predictive control,user centred smart building controls,users archetypes,cybersecurity,digital building logbook,res
BRIDGing the research and INnovation Gap for Rare Diseases in Europe by upgrading excellence of IMGGE (BRIDGING-RD)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Serbia,Sweden,Spain
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1440187.5
EU funding (EUR): 1440187.5
Participants: 4
Project status: SIGNED

There are over 330 million people living on the planet affected by one of over 6,000 identified genetic rare diseases (RD). They urgently need timely diagnosis and development of specific treatments. Although Europe leads the way in RD research, there is a clear gap in research and innovation (R&I) between countries. To bridge this gap, networking and knowledge sharing between IMGGE (Institute of Molecular Genetics and Genetic Engineering, Serbia) and 3 world-class counterparts at EU level - KI (Karolinska Institute, Sweden), CNAG (National Center for Genomic Analysis, Spain) and UAM (Autonomous University of Madrid, Spain) is envisioned. BRIDGING-RD’s objectives are: (1) upgrade the IMGGE RD Biobank to reach full interoperability of genetic and phenotypic data in order to increase participation in transnational research and innovation projects related to human health; (2) upgrade bioinformatics pipelines specific to RD to increase the rate of solved RD cases in IMGGE’s RD Biobank; (3) upgrade capacity for modelling of metabolic diseases as well as capacity to test small molecule drugs, in order to increase the number of translational studies; (4) upgrade research support offices in order to increase success in obtaining funds from research and/or innovation agencies, industry, foundations etc. Objectives will be achieved through staff exchanges, expert visits, trainings or workshops, conference attendance, joint summer schools and dissemination/outreach activities. Crucially, an exploratory R&I project, engaging all partners will focus on identifying an innovative drug, pharmacochaperone, for a selected metabolic RD. BRIDGING-RD will have impact by significantly improving the scientific excellence and innovation capacity of IMGGE, raising its research reputation and research management skills. It will also impact networking and mobility of qualified scientists in the RD field, thus boosting creativity and ultimately enhancing economic growth at the European level.

Keywords: rare diseases,genomics,transcriptomics,disease modeling,in vitro testing,pharmacological chaperones
A WIDER, STRONGER AND UNITED EUROPEAN RESEARCH AREA FOR THE SUSTAINABLE EXPLOITATION OF GEOTHERMAL RESOURCES. (HOCLOOP HOP-ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Norway,Poland
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 25.0
Total project cost (EUR): 514000.0
EU funding (EUR): 514000.0
Participants: 2
Project status: SIGNED

Geothermal energy has a large potential as a clean, renewable energy source. The proposed project is part of the HOCLOOP project, the idea of which is to use an innovative horizontal closed loop solution for the extraction of heat from deep or shallow formation rocks. The proposed project will expand research on the use of alternative circulation fluids to water, such as CO2-based and IL-based fluids, in line with the research planned in the HOCLOOP project and in full cooperation with the other partners. The work will also cover the investigation of a potential pilot site in Poland, covering environmental assessment and social acceptance. This is particularly important as this area is still dominated by carbon-intensive energy, and the transition to clean, renewable energy sources is a major challenge. An analysis of the Polish case study will be in line with the methodology outlined in the HOCLOOP project, with strong cooperation from other partners. In addition, the project will examine the feasibility of using the presented innovative source of renewable energy within a variety of existing or emerging industrial sectors. It is expected that the solution will enable the exploitation of geothermal energy sources as well as conditions in Poland and Central Europe. In addition, the implementation of the project will enable the establishment of extensive contacts between partners, promoting the transfer of knowledge, experience, and good practices to the widening country and supporting the career development of young researchers.

Keywords: geothermal energy,circular,sustainable,social acceptance,seismicity free geothermal exploitation,widening,spreading excellence
Disk Instabilities in Highly Accreting Neutron Stars (DIANA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Poland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: TERMINATED

Astrophusical accretion disks are the main engine of most of high energy sources. Although they have been studies for decades, we still do not know their exact structure and their evolution with luminosity. A clear example is at high luminosity, for which our best theory predicts the presence in all sources of an instability which leads to the cyclic disruption/rebuilding of the disk. However, from the observational point of view, we have observed only a handful of accreting black holes. My recent work has demonstrated that these instabilities can take place also in accreting neutron stars, opening a new way to study this still poorly understood process. The main objective of DIANA is to exploit the recent advancements in highly accreting binary systems to set the most stringent constrains on the evolution structure of the accretion disk around neutron stars near the Eddington limit. To achieve this, I will combine for the first time X-ray polarization measurements with fast O-IR observations. The synergy of these two groundbreaking techniques will allow me to link directly the variations of the accretion flow structure to the relativistic ejections observed in these systems. Building on these observational results I will develop the first 1-D model for accretion instabilities around accreting neutron stars. This will represent a significant advance in our understanding of accretion disks, as will allow us to compare the appearance in BH and NS, providing key constrains on the origin of instabilities, and informing future 3D global simulations.

Keywords: accretion disks,neutron stars,black holes,jets
Exploiting the Tumor Proteome Activity Status for Future Cancer Therapies (TOPAS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2272055.0
EU funding (EUR): 2272055.0
Participants: 1
Project status: SIGNED

Kinases are key regulators of protein activity and phosphorylate thousands of proteins in cells. The phosphoproteome can hence be viewed as a proxy for the proteome activity status of a cell. Dysregulation of the phosphoproteome can cause diseases such as cancer. As a result, kinase inhibitors have become important drugs in oncology and nearly 50 are approved for use in humans. As they typically have a range of targets, there is enormous potential for repurposing these drugs for other cancer entities. To implement this in the clinic, it is important to better understand: i) how the phosphoproteome of an individual tumor can be functionally interpreted, ii) how and to what extent kinase inhibitors modulate the phosphoproteome and iii) which drug is the best fit for modulating the proteome activity status of a particular tumor. This information is only partially or not available from classical cancer diagnostics or genomics. Therefore, the central aim of this project is to show that ground breaking new information for the diagnosis and treatment of cancer patients will come from measuring their tumor proteome activity status (TOPAS) by quantitative mass spectrometry. To this end, the first objective is to show that modulating the TOPAS of cancer model systems by kinase inhibitors functionalizes the phosphoproteome and reveals the cellular mechanisms of action of these important medicines. The second objective is to develop and validate diagnostic drug-, protein- and pathway-centric TOPAS scores able to make treatment suggestions based on the phosphoproteomes of cancer models and tumor tissues. The third objective is to demonstrate, on the example of sarcoma patients, that TOPAS scoring adds value to decision making by molecular tumor boards. Combining the strengths of proteomics and genomics, I aim for building a comprehensive multi-omics view on tumors and will create a ‘virtual tumor board’ in ProteomicsDB to make TOPAS available to the scientific community.

Keywords: clinical phosphoproteomics,precision medicine,kinase inhibitors,drug repurposing
New Environmental friendly and Durable conCrete, integrating industrial by-products and hybrid systems, for civil, industrial and offshore applications – EnDurCrete (EnDurCrete)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Spain,Italy,Germany,Norway,Switzerland,Norway,Poland,Belgium,Slovenia,Greece,Croatia,Hungary,France,Czechia
Call: Improved material durability in buildings and infrastructures, including offshore (H2020-NMBP-2017-two-stage, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 5912001.27
EU funding (EUR): 5912000.0
Participants: 18
Project status: CLOSED

The main goal of Endurcrete Project is to develop a new cost-effective sustainable reinforced concrete for long lasting and added value applications. The concept is based on the integration of novel low-clinker cement including high-value industrial by-products, new nano and micro technologies and hybrid systems ensuring enhanced durability of sustainable concrete structures with high mechanical properties, self-healing and self-monitoring capacities. Among key technologies there are: nano-enabled smart corrosion inhibitors, self-sensing carbon-based nanofillers, multifunctional coatings with self-healing properties and sensorised non-metallic reinforcement systems. Innovative design concepts will be developed for smart installation, disassembly and re-use of the new green pre-cast and cast in place elements aiming at enabling easy recycling and re-using approaches. The functionality of the developed concrete structures will be proved under severe operating conditions supported by experimental and numerical tools to better understand factors affecting durability and capture the multiscale evolution of damage as well as to enable service life prediction. Demonstrators will be tested in working sites of tunnels, ports and offshore structures, in order to prove the enhanced durability (+40%, i.e. +30 years) and decreased cost (-35%) of the new concrete systems in such critical applications. Innovation aspects such standardization, life cycle assessments, health and safety and training activities will be performed. Finally, in order to maximize the exploitation of findings and ensure dissemination and impacts beyond the project duration, business models and plans for the proposed solutions will be developed. The Consortium, led by HeidelbergCement and involving 16 partners (6 SMEs), will have a strong economic and social impact (1billion € and 6900 high quality jobs by 2025), considering concrete markets and related applications. The foreseen project duration is 3.5 year

Keywords: low clinker concrete,offshore structures,tunnels,harbors,durability,corrosion inhibitors,self healing,self monitoring,modelling,health structural monitoring
Intensity mapping of the atomic carbon CII line: the promise of a new observational probe of dusty star-formation in post-reionization and reionization epoch (CONCERTO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2025-06-30
Duration (months): 78.0
Total project cost (EUR): 3499942.24
EU funding (EUR): 2214437.0
Participants: 2
Project status: SIGNED

I propose for funding to construct a spectrometer to map in 3-D the intensity due to line emission, a technique known as Intensity Mapping. Instead of detecting individual galaxies, this emerging technique measures signal fluctuations produced by the combined emission of the galaxy population on large regions of the sky in a wide frequency (i.e. redshift) band, and thus increases sensitivity to faint sources. Capitalizing on a recent technology breakthrough, our intensity mapping experiment will measure the 3-D fluctuations of the [CII] line at redshifts 4.5<z<8.5. [CII] is one of the most valuable star formation tracers at high redshift. My project will answer the outstanding questions of whether dusty star-formation contributes to early galaxy evolution, and whether dusty galaxies play an important role in shaping cosmic reionization. My team will first build, test, and finally install the instrument on the APEX antenna following an agreement with APEX partners. The spectrometer will be based on the state-of-the-art development of new arrays in the millimeter using Kinetic Inductance Detectors. Spectra (200-360 GHz) will be obtained by a fast Martin-Puplett interferometer. Then, we will observe with CONCERTO a few square degrees and offer a straight forward alternative for probing star formation and dust build-up in the early Universe. Finally, CONCERTO will set to music the various cosmic evolution probes. Cross-correlation of the signals will be used in particular to capture the topology of the end of reionization era. CONCERTO will be one of two instruments in the world to perform intensity mapping of the [CII] line in the short term. The novel methodology is extremely promising as it targets an unexplored observable touching on some of the fundamental processes building the early universe. In the flourishing of new ideas in the intensity-mapping field, CONCERTO lies at the forefront.

Keywords: submillimeter and millimeter astronomy,high redshift galaxies,reionization