Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Self-organisation across the scales in early mammalian development (SelforganisingEmbryo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany,Netherlands
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 2239458.0
EU funding (EUR): 372230.0
Participants: 2
Project status: SIGNED

A defining feature of multi-cellular living systems is the capacity to break symmetry and generate patterns through self-organisation. Our project aims to understand the design principle of multi-cellular self-organisation, using a well-suited model system: early mouse embryos. In mammals eggs lack polarity and symmetry is broken during early embryogenesis, which results in segregation of three cell lineages in the blastocyst. Progressive expansion and coalescence of fluid-filled spaces form the blastocyst cavity that segregates the cavity-facing lineage from the rest. Despite extensive gene expression studies, how molecular and physical signals are dynamically coupled for self-organised blastocyst patterning remains poorly understood. We aim to identify the mechanisms of feedback between cell polarity, mechanics (contractility, adhesion, pressure) and fate operating across sub-cellular to whole organismal scales. For this, we adopt a unique set of strategies that integrate biology and physics: advanced live-imaging, quantification of molecular and physical parameters to integrate into lineage maps, reduced systems to establish physical models, and spatio-temporally controlled manipulations for functional validation of those models. We will build up complexities. At the single-cell level, we will study de novo assembly of the apical domain in relation to cell contact and cortical contractility. For inside-outside patterning, we aim to dissect the coordinated signalling between cell position and fate specification. Furthermore, we will study how fluid cavities, a yet unexplored parameter, contribute to cell sorting, apical polarisation and fate specification through generation of pressure and contact-free cell surfaces. Ultimately, we will reconstitute embryogenesis in silico, reveal emerging properties and design engineer the blastocyst. In all, this study will set a paradigm for studying self-organisation on subcellular to organismal scales.

Keywords: tissue mechanics,self organisation
Oralis, The first oral human insulin treatment for Type 2 Diabetes Mellitus (Oralis)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Type 2 Diabetes Mellitus (T2DM) affects 415M people globally, 49M of them within Europe. Caring for these individuals costs Europe €181M billion annually. However, more needs to be done as T2DM and its related co-morbidities claim hundreds of thousands of lives each year in the region. The early control of blood glucose levels (BGL) is the key to the prevention of the disease, and longer lifespans with better prognosis and higher quality of life for T2DM patients. The last century has seen considerable development in T2DM treatment, but the eventual solution to control BGL for many patients are multiple daily insulin injections. This has created a huge global market to be worth €49 billion (est. 2020). The pain, social stigma, and burden associated with injecting insulin contribute to a non-adherence to treatment that has been estimated to be as high as 61%, at a cost 9,649€ per patient per year. Oramed Pharmaceuticals (Oramed) will transform this paradigm with its POD™ technology. It protects protein therapies like insulin from the harsh conditions in the gastrointestinal tract, allowing then to be taken orally. This opens a way into oral insulin treatment to overcome many of the issues contributing to non-adherence of injected insulin treatment in T2DM patients. Using POD™ technology Oramed has produced the first oral insulin and demonstrated its efficacy in Phase II clinical trials with >300 patients and >5000 doses. We have proven oralis capability to deliver to the liver bioavailable insulin at sufficient concentration to produce significant glucose control in all glycaemic parameters in T2DM patients. Through the SME instrument Oramed will finalise the Phase III clinical trial to confirm the efficacy of oralis for glycaemic control in T2DM patients. We have already reach commercial agreements to commercialise oralis. Our estimation is to generate a similar revenue creation and market share as the newest injectable insulin options of €1.7 bn in 5 years.

Keywords: diabetes,oral insulin,oral treatment for diabetes,oral protein based drugs
CO2-based Electrosynthesis of ethylene oXIDE (CO2EXIDE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Austria,Germany,Austria,Hungary,Poland,Latvia,United Kingdom
Call: New electrochemical solutions for industrial processing, which contribute to a reduction of carbon dioxide emissions (H2020-SPIRE-2017, 2017)
Start date: 2018-01-01
End date: 2021-06-30
Duration (months): 42.0
Total project cost (EUR): 5420113.25
EU funding (EUR): 5420113.25
Participants: 13
Project status: CLOSED

The CO2EXIDE project aims at the development of a combined electrochemical-chemical technology for the simultaneous “200%” conversion of CO2 to ethylene at the cathode, water oxidation to hydrogen peroxide at the anode and a subsequent chemical conversion of both intermediates to ethylene oxide and oligo-/polyethylene glycol in a cascade, boosting this technology from TRL4 to TRL6. The CO2EXIDE technology combines a modular nature for the feasibility of a decentralised application, a high energy and material efficieny/yield and the substitution of fossil based production of ethylene oxide. The CO2EXIDE technology will be combinable with renewables and allows for the direct creation of products, which can be integrated into the existing supply chain. The reactions will be operated at low temperatures and pressures and forecast significant improvements in energy and resource efficiency combined with an enormous reduction of GHG emissions. All improvements will be quantitated using Life Cycle Assessment. The CO2EXIDE approach will bring together physicists, chemists, engineers and dissemination and exploitation experts from 5 universities/research institutions, 3 SMEs and 2 industries, innovatively joining their key technologies to develop and exploit an unprecedented process based on CO2, renewable energy and water to combine the chemical and energy sector. Within 42 months project duration, the CO2EXIDE technology will undergo a thorough material and component R&D programme. A 1kW PEM electrolyser for CO2-reduction and water oxidation in combination with an ethylene enrichment unit and subsequent chemical conversion cascade reactor will be manufactured to produce ethylene oxide as intermediate for oligo-/polyethylene glycol synthesis. This will prove the achievement of the quantified techno-economic targets of CO2EXIDE.

Keywords: co2 capture,pem electrolyser,electrochemical co2 reduction,electrochemical water oxidation,gas separation,ethylene,hydrogen peroxide,chemical catalysis,cascade reactor,ethylene oxide
Design for Open access Publications in European Research Areas for Social Sciences and Humanities (OPERAS-D)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Greece,France,France,Netherlands,United Kingdom
Call: Support to policies and international cooperation for e-infrastructures (H2020-INFRASUPP-2016-1, 2016)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 408586.25
EU funding (EUR): 408586.25
Participants: 6
Project status: CLOSED

OPERAS-D (Design) project will support the 5 main partners (“core group”) of the OPERAS network in the development of a European e-infrastructure for open access publications in the Social Sciences and Humanities (SSH). The project will address long-term requirements for the development of the e-infrastructure and community building, as well as seek to expand other interested parties within and beyond Europe, and in diverse fields of the SSH. To achieve this goal, the key objectives of the OPERAS-D project are to: -prepare a design study that defines governance models, structures and scientific and technical concepts for future services that the infrastructure will provide, and establishes a roadmap to achieve these goals according to the requirements for long term sustainability . -engage the current and future partners in the OPERAS network to strengthen the community and develop the network of partners participating in OPERAS across Europe, specifically in central European countries. The project will establish a roadmap for OPERAS consortium that includes e-infrastructure service providers (publishing platforms, libraries) and research and education communities (universities and university presses). It will define long term requirement by producing a user driven design for future services and the technical requirements to implement them and also a final governance model and business plan for OPERAS development. The community building will help all participants in OPERAS to have a clear picture of their technical environment and a better understanding of the different technical options within the community. It will gather all stakeholders in workshops to validate data collected during the project and to share the results and the vision for the development of the infrastructure. Operas-D will identify key stakeholders inside and outside Europe and engage them for potential collaboration with OPERAS.

Keywords: open science,open access,infrastructure,social sciences and humanities,scholarly communication
eM-POWERing SME Clusters to help SMEs to overcome the valley of death (MPowerBIO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Coordination and support actions
Partnership: BBI (Art-187)
Countries involved: Spain,Italy,Germany,Ireland,Spain,Serbia,Belgium,Belgium,Bulgaria,Greece,Denmark
Call: Empower SME clusters to bring SMEs ‘across the valley of death’ (H2020-BBI-JTI-2019, 2019)
Start date: 2020-05-01
End date: 2022-11-30
Duration (months): 31.0
Total project cost (EUR): 1578908.13
EU funding (EUR): 1499962.38
Participants: 11
Project status: CLOSED

The MPowerBIO project will obtain feedback from clusters, SMEs and investors on the concrete challenges they have regarding investments and build an online platform containing digital tools for evaluating investment readiness, as well as online training modules to build the capacity of clusters to train their SME members. The project will provide 10 training the trainers events for a total of 90 clusters across the bioeconomy, covering most of Europe, supported by the online platform. This will the improve the capacity of participating clusters to service their SME members, and allow them to test the learning on SMEs in a supervised manner, at a series of 10 regional events, helping the SMEs to prepare and present high-quality projects to investors. The best SME projects will be selected by investors, and invited to one of two European finals, which are based on the European Bioeconomy Venture Forum model, run by the consortium members. A total of 72 high-quality, screened and investment-ready SME are expected to pitch at the two final events. The proposal is based on two consecutive cycles, allowing 350 SMEs to be screened and supported over the project, with experience from the first cycle being used to improve the project second cycle. The proposal takes account of the difference in Europe in investment activities, the required skills for trainers and the different types of investors in each country. MPowerBIO will ensure that clusters become self-supporting in this respect on completion of the project, with the ability to maintain these skills within their own organisations. The project will produce a replication guide to ensure that project results can be widened to other areas after completion.

Keywords: business support,regional events,workshops,pan european events,venture capital,sustainability,replication guide,capacity building
Understanding how mitochondria compete with Toxoplasma for nutrients to defend the host cell (MITOvTOXO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Once a pathogen has eluded immune defences to establish a replicative niche in the cytosol, it requires nutrients to grow—the same nutrients that host organelles need for their biogenesis and to perform cellular metabolic processes. The microbe must therefore compete with organelles for these nutrients.. This organelle-microbe competition for metabolites is a fundamental, but little understood aspect of the host–pathogen interaction. I recently defined one example of this competition, between mitochondria and the human parasite Toxoplasma gondii. During infection, Toxoplasma exploits host lipophagy to gain access to cellular fatty acids essential for its growth. To counter this, host mitochondria fuse to enhance fatty acid uptake, limiting Toxoplasma access to a key host resource and thus restricting its growth. This work shows that mitochondria—essentially domesticated parasites—metabolically defend the cell during infection, and opens several key questions that I will address in this proposal, including: a) by what mechanism do mitochondria enhance fatty acid oxidation to defend the cell against fatty acid siphoning by microbes?; b) can mitochondrial fatty acid oxidation be exploited to restrict microbial growth in vivo?; and c) do mitochondria play a broader role in cellular defence by sequestering other essential metabolites from microbes? The answers to these questions will lead to a deeper understanding of the role of mitochondria in the cellular response to microbes, and begin to address our long-term goal of understanding how human metabolism influences the progression of infectious disease. The innovative approaches I describe here are broadly applicable to dissecting the metabolic interactions between other organelles and diverse infectious agents.

Keywords: mitochondria,parasites,toxoplasma gondii,nutrient competition,cholesterol,host pathogen,fatty acid,mitochondrial fusion,anti microbial therapy,cellular defense
Hybrid Organic Thermoelectrics: an Insight into Charge Transport Physics towards High-Performance Organic Thermoelctric Generators (HYTEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 171792.6
EU funding (EUR): 171792.6
Participants: 2
Project status: CLOSED

Thermoelectric generators (TEGs) which directly convert heat to electricity could be a valuable contributor to the world’s increasing demand for renewable energy. Organic semiconductors offer several unique advantages over inorganic materials, such as solution processable, flexibility and biocompatibility, thus development of organic thermoelectrics (OTEs) will enable applications not currently feasible with traditional inorganic thermoelectrics (ITEs). Preliminary results showed that the thermoelectric performance of two organic semiconductors can be significantly improved through an evaporation doping methodology as well as incorporation of nanomaterials such as black Phosphorus (BP). Although the breakthroughs are promising, the charge transport mechanism is still unclear. Without such an understanding, the OTE systems can never be optimised. It is the objective of the proposed project (i) to understand charge transport in the semiconductors and their nanocomposites by integrating experimental output into charge transport model, (ii) to optimise their thermoelectric performance based on understanding of the charge transport mechanism, (iii) to fabricate the a hybrid OTE system with optimised thermoelectric performance (i.e. P > 1250 μWm-1K-2, κ<0.5 Wm-1K-1, and ZT≥1), and (iv) to fabricate a prototype hybrid OTE generator and demonstrate its application as a flexible solar thermoelectric generator and/or wearable thermoelectric generator for electronic-skin.

Keywords: charge transport physics,organic thermoelectrics,semiconducting carbon nanotubes,semiconducting polymers,nanocomposites,heat recovery,energy harvesting
Novel processing of colloidal nanocrystals for optoelectronic applications (NANOPTO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-12
End date: 2018-09-11
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

NANOPTO aims at developing novel physicochemical routes to obtain a semiconductor matrix embedding dispersed quantum-dots (dots-in-matrix) starting from colloidal nanocrystals. In recent years, a multitude of different semiconductor materials have been synthesized and studied to increase the performance of current technologies or to develop new and attractive applications. As a first-order approximation, materials boosting high photoluminescence (PL) quantum yield (PLQY) possess low or hindered charge mobility, as pristine colloidal semiconductor nanocrystals (NCs). To overcome this limitation, many different NCs processing techniques have been developed, but all of them either cause the formation of charge trap-states on the NCs surface (thus quenching the PL) or do not significantly enhance the charge mobility. For this reason, NANOPTO will tackle this fundamental limitation of NCs by developing novel general methods to enhance their charge mobility without creating surface trap-states, thus leading the way to the development of more efficient light-emitting diodes (LEDs) and solar cells that can be processed in solution. In particular, NANOPTO aims at exploiting both chemical and physical routes to prepare colloidal core-shell NCs and solder their shells in solid-state thus creating a bulk semiconductor matrix (granting enhance charge mobility) embedding quantum-dots (granting the desired optical properties).

Keywords: quantum dots,colloidal nanocrystals,cdse,light emitting diodes,photovoltaic,optoelectronics
Understanding the links between functional traits and ecological processes in lake Arcellinida (testate amoebae) (‘ECOTRAIT’) (ECOTRAIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Testate amoebae, shelled unicellular eukaryotes, are common in freshwater and moist terrestrial environments. Their shells preserve well in the fossil record and species assemblages have been shown to be sensitive indicators of water quality change, and thus useful in environmental monitoring. Whilst the ecology of the group is reasonably well understood, a determination of their role in specific ecosystem processes has been hampered by taxonomic uncertainties. As the living cell quickly decays after death, taxonomic divisions have relied on shell morphology. This approach is problematic as genetic analysis has shown that some species display morphological plasticity, partially in response to environment, whilst other specimens with similar morphologies have been demonstrated to be distinct ‘cryptic’ species. This project will utilise techniques used by the two research communities to develop more refined methodologies to characterize test morphology (e.g., notably functional trait analysis) to provide a powerful new framework for understanding microbial food-webs and community responses to ecological stressors over multiple time-scales. Specifically, the project will apply these interdisciplinary methodologies to examine the controls on morphology in Arcellenida, the dominant testate amoebae found in lakes to: 1. examine causes of functional trait variability in modern and palaeolimnological settings; 2. develop novel biometric trait delimitation approaches using SEM imagery and 3D imaging software; 3. use genetic sequencing on select morphospecies, to test the hypothesis that variations in shell morphology are a response to environment; 4. evaluate the significance of trait-based approaches for understanding temporal changes in species composition. This research will significantly contribute to the training of the researcher, enhancing future career opportunities, as well as expanding the collaborative research network and skills of the host.

Keywords: palaeolimnology,microbial ecology,water quality,functional traits