Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanocoating deposition of anti-fingerprint and fluorine free material on glass for optical lenses and solar panels industry (Nadam-G)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-04-01
End date: 2019-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Today the glass lenses and solar panels have a low durability and are easily stained with undesirable fingerprint, oil, dust and environmental pollutants decreasing the efficiency of their optical properties and generating and extra cost and time for their cleaning. In addition, the most current approaches for achieving an amphiphobic material (repels water and oil) rely on fluorinated compounds such as perfluoroalkyl sulfonates (PFAS)s. However, these fluorinated compounds may be carcinogenic for animal and humans at relatively high dose levels with strong evidence for connection between exposure to them and several forms of cancer. There is a necessity to find an effective, self-cleaning material with a high durability that provides glass surfaces with a high resistance to ngerprinting. In response, our companies ONYRIQ (ON) and ADVANCED NANOTECHNOLOGIES (AD) have developed NaDam-G (Nanocoating Deposition of amphiphobic and fluorine free material on Glass), an innovative technology consisting of a fluorine-free(avoiding the damage to health and environment), anti-fingerprint (avoidance of fingerprint and smudges) and self-cleaning (inherent ability to remove dirt), polymeric material covalently bonded on glass by Plasma Enhanced Chemical Vapour Deposition (PECVD). NaDam-G imparts high-durability for optical lenses and solar panels (increasing the efficiency by 3.5 % and generating an extra 25% of electricity) while being self- cleaning reduces cost and time consuming. Having validated the reliability of the NaDam-G system at the pilot scale, we now want to finalise its development and achieve market preparedness. In Phase 1 we aim to carry a Feasibility Study to warrant the project from a technical, commercial and financial point of view. Besides the crucial benefits that it will bring to nanocoating sector, NaDam-G will boost the growth of ON and AN, expecting to gain € 43million profits and 26 new people after 5 years in the market, reaching a ROI of 16.3.

Keywords: anti fingerprint,pecvd,nanocoating deposition,solar panel,optic lenses,amphiphobic glass,fluorine free,high durability,high vacuum system
Spatial and demographic dynamics of disease transfer at the wildlife-human interface (SENTIMOUV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2022-04-22
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Infectious diseases present a significant and growing threat to public health, domestic livestock production, and biodiversity conservation. Due to their global distribution and wide-ranging movements, seabirds are important vectors for the spread of pathogens across continents and ocean basins. Coastal seabirds, which associate with and exploit anthropogenic food sources, are particularly likely to interact with human-associated pathogens and zoonotic agents, making them useful candidates for monitoring disease prevalence. However, many factors mediating the interactions between seabirds and pathogens remain unknown or poorly understood. Our study will combine targeted field data collection, laboratory analysis, and quantitative modeling to develop a mechanistic understanding of the factors affecting prevalence and transmission of infectious diseases by seabirds at the wildlife-human interface. We will explore spatial and demographic factors affecting exposure and transmission rates for two key zoonotic diseases, toxoplasmosis and avian influenza, by a generalist coastal seabird, the yellow-legged gull (Larus michahellis) in the western Mediterranean basin. Within this study system, we will combine movement analysis using biologging, serological sampling, habitat and demographic analysis, and agent-based models to develop a comprehensive understanding of epidemiological dynamics. We will also use experimental studies to directly test the development of disease immunity in nestling birds and the effects of management actions on disease transfer. We will then apply scenario planning to study the effects of both management and habitat change on disease dynamics. Our results will not only improve understanding of gulls as vectors for infectious agents, but also provide a comprehensive quantitative framework for modeling disease dynamics that can be adapted to predicting and managing the spread of infectious disease at the wildlife-human interface.

Keywords: disease dynamics,immunology,spatial ecology,management
Focal Adhesion Kinetics In nanosurface Recognition (FAKIR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2021-07-31
Duration (months): 72.0
Total project cost (EUR): 2128895.0
EU funding (EUR): 2128895.0
Participants: 1
Project status: CLOSED

The provision of advanced functional materials in the area of regenerative medicine and discovery applications depends on many different factors to provide the appropriate targeted function. As adherent cells also read their environment through substrate interactions there is a great interest in developing such substrates in a predictable manner. Their first point of contact is through their focal adhesions and it is also though them that forces are applied allowing the cell to migrate and establish cytoskeletal tension which in turn regulates cell function. The objective of this project is to investigate the cell-substrate interaction at the nanoscale and correlate that to the surface topography for predictable biomaterials. Through the application of state-of-the-art nanofabrication we will fabricate precise surface topographies with length scales comparable to the structural units found in the focal adhesions. The aim is to map and understand the topographical influence in the architectural arrangement of the proteins in the adhesions. Aided by high resolution microscopy we will classify cell types on different nanotopographies. Combining that information with machine learning, we will be able to gain information about cell characteristics from the rule set. That information can also be used in reverse to identify cell types with the previously defined characteristic. This approach is similar to face recognition seen on cameras and mobile phones. The proposed research project will not only provide insight to an area of biomaterials not previously explored, yet aim to provide a blueprint for future design of biomaterials.
Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders (UNEXPECTED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2021-01-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Mechanisms of self-renewal in hematopoietic stem cells (HSCs) have been subject to intense studies during the last decades. However, this is still a poorly defined process and very limited progress has been made in the long sought goal of expanding HSCs ex vivo to allow for critical improvements of bone marrow transplantation procedures for cancer patients and potentially a broader use of HSCs in gene therapy and regenerative medicine. The aim of this research program is to systematically identify and characterize regulators of self-renewal in human HSCs and to develop strategies for stem cell expansion. Within the project we will develop novel paradigms for CRISPR (clustered regularly interspaced short palindromic repeats) mediated gene editing in primary human HSCs to enable detailed assessment of gene function. We will further employ forward genetic screening approaches based on both CRISPR/Cas9 gene editing and RNA interference (RNAi) gene silencing to identify regulators of renewal and differentiation in human HSCs. Large numbers of HSCs will be targeted with genome-wide lentiviral CRISPR (sgRNA) and short hairpin RNA (shRNA) libraries. Screening assays for HSC self-renewal will be evaluated in a pooled format and de-convoluted using next generation sequencing, allowing thousands of perturbations to be assayed in parallel. Candidate genes from the screens will be studied further using genetic barcoding and transplantations assays in immundeficient mice to test whether they can be targeted to induce expansion of HSCs ex vivo. Finally, based on our findings, we aim to develop GMP compatible conditions for HSC expansion in preparation for clinical trials involving expansion of umbilical cord blood derived stem cells to treat patients with acute leukemia.

Keywords: hematopoiesis,transplantation,crispr,cas9,stem cell expansion,genetic barcoding
Novel solutions for assessing child cognitive function (ChildCogn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-02-01
End date: 2016-07-31
Duration (months): 18.0
Total project cost (EUR): 148708.75
EU funding (EUR): 148708.75
Participants: 2
Project status: CLOSED

An important responsibility of primary health care in most societies is to conduct regular check-ups of children’s physical, cognitive, and social development, and to identify problems at an early stage to arrange for appropriate support and special care. Whereas well-validated methods exist for monitoring physical growth (e.g., WHO growth standards), there is a lack of standardized methods for monitoring other key aspects of early development (e.g., cognitive development). The present project examines the possibilities to develop novel solutions for assessing children's cognitive function. The project activities are aimed at developing the concept of new types of cognitive assessment techniques, testing of a prototype, and surveying end-user experiences and potential markets for the prototype.

Keywords: cognitive development,assessment,health care
Fundamentals of Holographic Dualities via Non-relativistic Systems and Quasinormal Modes (DualNRSQNM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Since their advent, holographic dualities have been a major focus of theoretical physics research. These dualities are maps between field theories in d dimensions, and gravities in d+1 dimensions. In these maps, any physical quantity in the field theory has a dual in the gravitational theory, and vice versa. "Dual" means that a calculation in the field theory will always give the same answer as a calculation in the gravitational theory (and vice versa). These dualities thus provide powerful access to new physical descriptions. They have been applied far beyond their original high-energy theoretical physics regimes, to subjects ranging from superconductors to heavy-ion collisions. This project will study the underpinnings of holographic dualities for applications to non-relativistic systems like superconductors. In order to put these conjectured applications on stronger footing, this project will also examine the role played by "quasinormal modes" in dualities. During her graduate work at UC Berkeley, and her postdoctoral positions at Harvard and University of Michigan, the proposed fellow has acquired ample research experience in the areas covered in this proposal, and will be able to expand on collaborations with some of the world experts in the field. The proposed host institution, the Niels Bohr Institute (NBI), provides an ideal fertile environment for developing research at the forefront of physical understanding, and particularly so for this project due to local expertise among its faculty, postdocs, students, and thriving international visitor program. During this project, the fellow will acquire further skill in the cross-disciplinary areas of the proposal, including condensed matter physics as well as mathematics. The host, fellow, and the EU as a whole will benefit from the international exchange of ideas results from the mixing of the fellow's US backbackground with the strong EU-wide connections of the host institution.

Keywords: holography,applied holography,quasinormal modes,partition functions
Characterizing Adaptation and Migration Events with Modern and Ancient Genomes (CAMERA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Switzerland,Switzerland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-08-01
End date: 2023-07-31
Duration (months): 84.0
Total project cost (EUR): 1498478.0
EU funding (EUR): 1438018.37
Participants: 2
Project status: SIGNED

BACKGROUND Ancient DNA research has recently entered the genomics era. Performing “ancient population genomics” is now technically possible. Utilizing the temporal aspect of this new data, we can address fundamental evolutionary questions such as the amount of selection acting on the genome or the mode and tempo of the colonization of the world. AIMS The overall goal of the proposed research is to (i) generate and analyse data to answer two long standing questions in human evolution: understanding the molecular basis of human adaptation to high altitude and investigating the timing of the Polynesian-South American contact, (ii) develop statistical approaches that combine ancient and modern genetic data to estimate the timing and the intensity of a selective sweep and an admixture event. METHODOLOGY Application: We will collect, date and DNA sequence human remains. Combining the ancient genetic data, 14C dates with existing modern genomic data will allow us to increase the resolution as to the timing of the adaptive and the admixture event, respectively, while generating unique datasets. Theory: We will build on existing methods based on one-locus classical population genetic models to develop tools to analyse whole genome time serial data. RELEVANCE Ecological: The results will address the fundamental question of how much of the human genome is undergoing selection, better characterize one of the textbook examples of adaptation in humans and contribute to our understanding of the peopling of the Americas. Medical: We will gain insights into the fundamental stress physiology experienced at high altitude and therefore into altitude-related illnesses. Methodological: The methods developed in this project will not only benefit the growing field of ancient genomics but also other fields where data is collected in a temporal manner, such as experimental evolution and epidemiology

Keywords: ancient dna
Demonstration and implementation of an integrated process for the Plasma-Enhanced Chemical Solution Deposition of PMMA-multicomponent coatings on wood and wood-based substrates (PlasmaSolution)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Slovenia
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 157287.6
EU funding (EUR): 157287.6
Participants: 1
Project status: CLOSED

This action will implement the new Plasma-Enhanced Chemical Solution Deposition (PECSD) technique for coating of wood and wood-based substrates. This technique synergistically employs plasma-chemistry in the gas phase and polymer chemistry in the liquid formulation, thus combining all benefits of conventional surface coatings and plasma-based deposition technologies. This will be carried out as a novel integrated process for the continuous coating of substrates including three steps: (a) Plasma pre-treatment for optimized substrate wetting and liquid uptake, (b) Application of poly(methyl methacrylate) (PMMA)-based liquid formulations including various additives, (c) Film formation via fast plasma curing. This overall goal is divided into three main objectives: Objective I: Building the integrated device, Objective II: Optimization of the deposition parameters, and Objective III: Demonstrating the technique’s capability and priming the industrial implementation. These objectives can only be achieved in the proposed collaboration, i.e. with my knowledge of plasma deposition and design of suitable devices, the wood coating experts’ knowledge of surface wood finishing at the University of Ljubljana, as well as the knowledge of plasma and surface diagnostics at the Jožef Stefan Institute. This complementarity is unique in all of Europe and will ensure the success of the action. Further, the knowledge exchange will not only help me to implement a stable career path in research and innovation, but also yield a cross-border propagation of this new and innovative field of research. The cross-cutting objectives especially extend the new technique to contribute to the pan-European sustainable development by implementing a novel environmentally friendly production technique that will allow to use renewable (e.g. wood-based) resources in novel settings. The transfer of this technology to the industrial sector will be already primed by the action.

Keywords: dielectric barrier discharge,thin film deposition,wood surface finishing,wood polymer composites
Mathematical modelling of nanoscale heat flow and phase change (NanoHeat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-12
End date: 2018-09-11
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The nanoparticle (NP) lies at the very heart of nanotechnology. The wide range of current and potential uses of NPs, which include medicine, manufacturing, environment, and energy, has stimulated an international research effort focusing on NP synthesis and design. Despite extensive research into NPs, many breakthroughs and advances are the result of trial and error, since the mathematical framework which could provide a theoretical understanding often does not exist. This is partly because classical theories of heat transfer and phase change, which are relevant to the design and use of NPs, breakdown on the nanoscale. The focus of the proposed research is, therefore, to develop and analyse novel mathematical models describing nanoscale heat transfer and phase change. Exact, approximate, and numerical solutions will be obtained in order to gain practical insights into NP evolution. To ensure the models and results are realistic and of use to nanoscience researchers, the work will be carried out in collaboration with members of the Inorganic Nanoparticles Group of the Catalan Institute for Nanoscience and Nanotechnology, and the Statistical Physics Group at the Autonomous University of Barcelona. The project, which is truly multi-disciplinary, will bridge the gap between mathematics and nanotechnology.