Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cyber security system with a high IoT network visibility and fast vulnerability detection for Smart Homes. (Eye-O-T)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Israel
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today there are around 800 million connected devices in Smart Homes, which forecasted to reach 2 billion devices by 2020 - an uptick of about 250 million new devices per year. Smart Home networks become crowded, difficult to maintain and vulnerable. Today’s Smart Home systems, such as smart TVs, Internet-connected camera systems, alarm sensors, smart light bulbs or thermostats, can be hacked only in few minutes and provide a wealth of data about the way people live, bank information, legal information and etc. Perytons proposes a centralized diagnostic solution for the Smart Home Operators, called Eye-O-T. The Eye-O-T enables the operators to monitor and analyze in real time a large number of IoT networks, distributed over many remote sites and running different local communication protocols. The system is composed by plug & play probes that capture Smart Home IoT edge and gateway traffics and send it to the cloud through the existing broadband infrastructure; and an intuitive real-time dashboard. The Eye-O-T security system not only enables Smart Home owners to minimise their house and privacy vulnerability to security breaches and malicious attacks, but also reduces the Smart Home maintenance cost for operators by 30% and increases the operator’s deployment capacity of at least 10%. The Phase 1 project will allow Perytons to define a minimum viable product, plan a feasible cyber security and centralized monitoring system scale-up, elaborate the business scale up, and size the reachable market and a reliable market share. Within the overall project, Perytons aims to: scale up the solution to be able to support large scale IoT network deployment, ingrate the system with one large cloud service, interface the solution with common Network Management solutions and demonstrate Eye-O-T visibility and security trough a large scale pilot in houses with 300 probes deployed in Germany and the UK together with Smart Home Operators.

Keywords: cyber security,internet of things,smart home,non wifi,communication protocols,cyberspace
COMPACT BIOPHOTONIC PLATFORM FOR DRUG ALLERGY DIAGNOSIS (COBIOPHAD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Austria,Spain,Germany,Norway,Romania,France,United Kingdom,United Kingdom
Call: Cross-cutting ICT KETs (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2019-07-31
Duration (months): 43.0
Total project cost (EUR): 4288094.19
EU funding (EUR): 3734780.64
Participants: 13
Project status: CLOSED

Drug hypersensitivity to antibiotics, mainly Beta-lactams (BLCs) affects more than 2.5 million European citizens. Moreover, preventable adverse drug reactions are estimated in additional hospitalization costs of 1750-4500 €/patient. Currently, the allergy diagnosis is mainly based on the information given by invasive, single, and risky in vivo assays. In daily practice, few in vitro diagnostic methods are available and only used at the tertiary health services. These tests also lack of sensitivity (>0.35 kUA/L) and selectivity (<98%), resulting in an inaccurate diagnosis, analyze few drugs allergens (5), are time consuming (60-180 min), and expensive (30 €/allergen). COBIOPHAD aims the development of an innovative in vitro diagnostic (IVD) device for diagnosis of IgE-mediated drug allergies by building an integrated biophotonic system based on compact disc technology. For that, key enabling technologies will be integrated in order to achieve high sensitive (<0.1 kUA/L), selective (>98%), multiplexed (10 BLCs), rapid (30 min), and low-cost (2.4 €/allergen) drug allergy test. The solution involves an advanced approach to the diagnosis and management of drug allergy with the aim to ameliorate patient safety. The consortium comprises multidisciplinary knowledge on optics, electronics, advanced materials, biotechnology, smart microstructures, microfluidics, surface/organic chemistry, allergy, manufacturing systems, and telecom networking. Also, the key industrial actors, present in the consortium, will contribute to the manufacturing and placing the product on the IVD market.

Keywords: biophotonics,electronics,advanced materials,low cost manufacturing,compact disc technology,personalized telemedicine,drug allergy,betalactam antibiotics,haptenized determinants
E-marketplace for HORECA industry buyers, sellers and transporters (Supp.li)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Hungary
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Large corporations dominate the food retail and wholesale industry in Europe. Supp.li is a multi-sided online platform, with the objective to liberate the foodservice market as Uber or Airbnb did with their specific industries. It provides for all HORECA sellers, buyers and transporters an equal and open service that speeds up their go-to-market activities domestically and internationally, helps them reach more consumers with lower costs, finalize the selling/shipping/buying interactions faster with less interim costs. It also makes software supported business intelligence data widely available for them vs. zero or only semi-digital distribution options. Supp.li in Phase 1 will prepare the feasibility assessment that will validate the further development in terms of business and technical viability, also by involving HORECA buyers, sellers and transporters.

Keywords: e commerce,horeca,food industry,retail,european consumers,online platform,food producers
The influence of the cell membrane asymmetry and curvature on the functioning of membrane proteins and the transport of therapeutic compounds (assymcurv)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Estonia,Ukraine,Poland,Lithuania,Latvia,France,United States,Brazil
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 202500.0
EU funding (EUR): 202500.0
Participants: 9
Project status: CLOSED

Real cell membranes are essentially asymmetric and non-planar. Outer leaflets of the plasma membranes contain neutral lipids and glycolipids, while the inner leaflets host practically all anionic lipids and phosphoinositides. In addition to asymmetric composition the membranes are usually curved due to spontaneous curvature of the membrane lipids and an influence of membrane proteins and cytoskeleton. There are many cellular phenomena, which are influenced by the asymmetry and the membrane curvature such as formation of synaptic vesicles, blebs and apoptotic bodies, membrane fusion and splitting, budding of enveloped viruses, endo and exocytosis, etc. In this work we propose comprehensive interdisciplinary study of the influence of membrane asymmetry and curvature on the functioning of integral membrane proteins and the transmembrane transport of therapeutic compounds (such as cisplatin and its derivatives). The goal is to reveal major physical factors, which distinguish asymmetric and curved membrane environment and govern interactions, orientation and diffusion of the small molecules (drugs) and large integral proteins. The combination of experimental methods (“wet” biochemistry and molecular biology, enhanced infrared and Raman spectroscopy) and computer simulations (coarse-grained and atomistic molecular dynamics, quantum chemistry) would be used in the project in complimentary manner.

Keywords: lipid membranes,membrane proteins,transmembrane translocation,metal containing drugs,molecular dynamics,quantum chemistry,spectroscopy,surface enhanced spectroscopy
Forward Slice Core (FSC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Belgium
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-05-01
End date: 2022-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

There are two major flavors of processor core microarchitectures, namely the in-order core and the out-of-order core. Out-of-order processors deliver high performance while incurring high design complexity, large chip area and high power consumption. In-order processors on the other hand feature low complexity, small chip area and low power consumption, but deliver limited performance. There is a clear need for a novel core microarchitecture that delivers high performance at low hardware complexity, low cost and low power consumption. This is of particular interest for mobile and edge devices (e.g., tablets, smartphones, smartwatches, etc.) where increasingly high performance is needed at low cost and low power consumption. The mobile and edge device market is a huge market which continues to grow. High-performance out-of-order processors are too costly and too power-hungry, while in-order processors deliver insufficient performance for the increasingly high-performance demands of emerging mobile and edge workloads and use cases. We propose a novel core microarchitecture, called the Forward Slice Core (FSC) microarchitecture, which provides high performance at low cost and low power consumption. FSC achieves a dramatic improvement in efficiency by replacing the expensive and high-complexity out-of-order hardware with much simpler in-order hardware queues into which instructions are intelligently steered for high performance using the notion of a load's forward slice. FSC has the potential to improve performance per Watt per euro by at least an order of magnitude. The overall objective of this PoC project is to build a strong benchmarking and IPR portfolio to convince potential processor manufacturers to license the Forward Slice Core microarchitecture. The project will strengthen the evaluation of the FSC proposal through simulation and real-hardware implementation, and develop a licensing strategy for commercialization.

Keywords: computer architecture
Steering attosecond electron dynamics in biomolecules with UV-XUV LIGHT pulses (STARLIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany,Italy
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-12-31
Duration (months): 69.0
Total project cost (EUR): 1497000.0
EU funding (EUR): 812500.0
Participants: 2
Project status: CLOSED

One of the challenges facing science is to understand the chemical origin of DNA damage-induced mutations. Upon exposure to UV light, DNA nucleobases become electronically excited. This process potentially favors mutagenic miscoding of the DNA sequence. The main target of STARLIGHT is to study with unprecedented temporal resolution (few-femtoseconds/attoseconds) the electron dynamics occurring in UV photoexcited biomolecules. I will mainly consider aromatic complexes including DNA nucleobases (and ultimately DNA) with the aim of tracking in real time the electron dynamics preceding structural changes potentially leading to damage. The proposed research is based on a bottom-up approach: it allows one to understand the physical origin of a variety of light-driven processes occurring in more complex biological systems of crucial importance in photochemistry and photobiology, with tremendous prospects in phototherapy. Electron motion in molecules occurs on a temporal scale ranging from few femtoseconds down to attoseconds. Attosecond science is nowadays a well-established field and electron dynamics has been successfully studied in atoms and small molecules. The work recently conducted by the PI has demonstrated that this technology is mature and ready to be applied to more complex systems such as biomolecules. Electron dynamics will be resonantly activated in biomolecules by few-cycle UV pump pulses and subsequently probed by as-XUV pulses or few-fs-UV pulses. Through time-resolved measurements of the molecular photo-fragmentation, gas-phase spectroscopy will be used to elucidate the role of electrons in the photoreactivity of the molecule in a solvent-free environment. With the final goal of steering the electronic motion, circularly polarized UV pulses will be also used to induce electronic currents in cyclic biomolecules. These ring currents can be exploited to generate intense magnetic fields with promising applications in molecular electronics and quantum control.

Keywords: attosecond science,ultrafast laser spectroscopy,electron dynamics in biomolecules,dna damage
Integrable Random Structures (IntRanSt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Ireland,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 1579298.75
EU funding (EUR): 1287861.18
Participants: 3
Project status: CLOSED

The last few years have seen significant advances in the discovery and development of integrable models in probability, especially in the context of random polymers and the Kardar-Parisi-Zhang (KPZ) equation. Among these are the semi-discrete (O'Connell-Yor) and log-gamma (Seppalainen) random polymer models. Both of these models can be understood via a remarkable connection between the geometric RSK correspondence (a geometric lifting, or de-tropicalization, of the classical RSK correspondence) and the quantum Toda lattice, the eigenfunctions of which are known as Whittaker functions. This connection was discovered by the PI and further developed in collaboration with Corwin, Seppalainen and Zygouras. In particular, we have recently introduced a powerful combinatorial framework which underpins this connection. I have also explored this connection from an integrable systems point of view, revealing a very precise relation between classical, quantum and stochastic integrability in the context of the Toda lattice and some other integrable systems. The main objectives of this proposal are (1) to further develop the combinatorial framework in several directions which, in particular, will yield a wider family of integrable models, (2) to clarify and extend the relation between classical, quantum and stochastic integrability to a wider setting, and (3) to study thermodynamic and KPZ scaling limits of Whittaker functions (and associated measures) and their applications. The proposed research, which lies at the interface of probability, integrable systems, random matrices, statistical physics, automorphic forms, algebraic combinatorics and representation theory, will make novel contributions in all of these areas.
Heart monitoring and early assistance in high risk crisis without patient intervention (COPCAR) (COPCAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cardiovascular diseases (CVDs) are the main cause of death in Europe according the European Heart Network. The reaction time when first symptoms are detected is crucial to ensure the survival probability of the patient. In fact, delays in attending people who is suffering a ardiovascular accident may cause death or irreparable sequels. The first two hours are critical to avoid that, and many times, people take too much time in asking for help because they don’t clearly identify they are suffering a cardiovascular accident, mainly if is the first time for the patient. We have identified the following needs affecting patients with chronical heart diseases: - Need of prompt intervention in risk crisis to avoid deaths. - Need of monitoring patients at risk to detect early symptoms of cardiovascular accidents. And we have developed COPCAR, an intelligent system that solves them. Moreover, COPCAR: - is interconnected with the emergency services (1-1-2 number, via FRESS 112), reducing response time up to 80%, - distinguishes between event that should be taken into account, urgency event and emergency event depending on the gravity, - doesn’t need patient intervention.

Keywords: heart,monitoring,alert system
Towards circular economy in the plastic packaging value chain (CIRC-PACK)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Spain,Italy,Germany,Spain,Croatia,Türkiye,Croatia,Türkiye,France,Netherlands,United Kingdom
Call: Systemic, eco-innovative approaches for the circular economy: large-scale demonstration projects (H2020-CIRC-2016TwoStage, 2016)
Start date: 2017-05-01
End date: 2020-06-30
Duration (months): 38.0
Total project cost (EUR): 9254177.86
EU funding (EUR): 7308180.13
Participants: 24
Project status: CLOSED

CIRC-PACK project aims at more sustainable, efficient, competitive, less fossil fuel dependence, integrated and interconnected plastic packaging value chain. To this end, three case studies will work in developing, testing and validating better system-wide economic and environmental outcomes by i) decoupling the chain from fossil feedstocks, (ii) reducing the negative environmental impact of plastic packaging; and (iii) creating an effective after-use plastics economy. All in all, the work will be supported by non-technological analysis and advanced methodological analysis (including circular economy and industrial symbiosis principles) which will trigger a broadly deployment of the tested solutions. CIRC-PACK project will provide breakthrough biodegradable plastics using alternative biobased raw materials, which will have an instrumental role to play in the subsequence steps of the plastic value chain. In addition, eco-design packaging for improving and end-of-life multilayer and multicomponent packaging will be technologically advanced and adapted also to the new materials produced. Thus these developments will also contribute with a great impact in the packaging footprint, and increasing the biobased content and using compostable materials. Lastly, a multi-sectorial cascaded approach along plastic packaging value chain will be applied with critical impacts in other value chains beyond the targeted plastic packaging value chain. The overall outcome of the project will facilitate the transition from the current linear plastic packaging value chain to circular economy principles.

Keywords: plastic,packaging,design,biobased,biodegradable,recycling,new business models,organizational innovation,plastics landfill reduction
Reducing Early Atrophy with Leucine during Immobilization of Skeletal Muscle (REALISM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Recovery from injury, illness, and/or disease is associated with skeletal muscle disuse. Muscle disuse leads to a loss of muscle mass, strength, and functional independence, and represents a “catabolic crisis” for the elderly who are already at a greater risk for low muscle mass and strength due to age-related sarcopenia. Muscle mass is determined by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). When MPB exceeds MPS, the result is a negative net protein balance and muscle loss. Decreased MPS rates occur following the onset of immobilization-induced disuse, but there is no information on the response of MPB. mRNA and protein expression data indicate that the early stages of disuse (0-5 days) result in activation of the ubiquitin proteasome system, and presumably MPB suggesting that the initial stages of disuse represent a critical period to intervene with appropriate countermeasures to attenuate the loss of muscle mass and strength. Leucine is a key amino acid in the regulation of muscle protein metabolism that has been shown to inhibit MPB. The current proposal REALISM will 1) identify whether MPB is elevated during the early stages (72 hours) of immobilization-induced disuse, 2) determine whether leucine can reduce MPB and the loss of muscle mass during the early stages of immobilization, and 3) determine whether leucine can preserve muscle mass and strength in the elderly during more prolonged periods of immobilization. REALISM will identify the mechanisms underlying disuse atrophy in response to immobilization and examine potential therapeutic strategies to offset the loss of muscle mass and strength. The M3 laboratory of Dr. van Loon at Maastricht University (UM) offers the most ideal environment for me to conduct REALISM, and take a major step towards the achievement of my career goal of setting up my own research program and establishing myself as an independent scientist.