Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Active Distribution networks with full integration of Demand and distributed energy RESourceS (ADDRESS)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Smart energy networks
Action type: Collaborative project
Countries involved: France,Spain,Switzerland,Spain,United Kingdom,Finland,Belgium,Netherlands,Sweden,Italy,France,Spain,Romania,Netherlands,Belgium,Germany
Call:  (FP7-ENERGY-2007-1-RTD, 2007)
Start date: 2008-06-01
End date: 2013-05-31
Duration (months): 60.0
Total project cost (EUR): 16541647.0
EU funding (EUR): 8999997.0
Participants: 27
Project status: CLOSED

ADDRESS will research, develop and deploy technologies and processes to increase usage of Distributed Generation and Renewable Energy Resources thereby engaging in a new relationship between customers, generators and network operators. ADDRESS aims to develop new innovative architectures for Active Distribution Networks (ADN) able to balance in real time power generation and demand allowing network operators, consumers, retailers and stakeholders to benefit from the increased flexibility of the entire system. Innovative use of communications, automation and household technologies will be combined with new trading mechanisms and algorithms providing ADN with low cost and reliable solutions. Customers will be encouraged into active participation enabling them to change their consumption habits, adopting a smarter use of energy and saving money. A cost/benefit analysis of different solutions will be developed: the most promising will be tested in three sites with different geographic, demographic and generation characteristics. The consortium has a distinguished membership of Large, Medium and Small Enterprises with international experience. East and West European Utilities, Global Manufacturers (both power and appliances), Universities, Consultants, Communications Suppliers and R&D Specialists have been selected for their specific knowledge and experience providing a well balanced mix of technology, innovation and market orientation. Competencies cover the whole spectrum of the electricity supply chain making this consortium extremely well suited to acheive the project goals and to deliver flexible, reliable, environmentally friendly and economic solutions. FP7 has provided the opportunity for this collaboration to take place completely meeting the Work Programme aims and enabling European Utilities and stakeholders to be on the cutting edge in worldwide network management.

Keywords: active distribution networks,integration demand resources,renewables,energy management,prosumers
Migration and integration of GABAergic interneurons into the developing cerebral cortex: a transgenic approach (INTERMIG)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: United Kingdom
Call:  (ERC-2007-StG, 2007)
Start date: 2008-07-01
End date: 2014-08-31
Duration (months): 74.0
Total project cost (EUR): 1250000.0
EU funding (EUR): 1250000.0
Participants: 1
Project status: CLOSED

Inhibitory interneurons function as modulators of local circuit excitability. Their properties are of fundamental importance for normal brain function therefore understanding how these cells are generated during development may provide insight into neurodevelopmental disorders such as epilepsy and schizophrenia, in which interneuron defects have been implicated. Inhibitory GABAergic interneurons of the cerebral cortex (pallium) are generated from proliferating subpallial precursors during development and migrate extensively to populate the cortex. The aim of this proposal is to identify genetic pathways and signalling systems that underlie cortical interneuron migration and integration into functional neuronal circuits. Distinct interneuron subtypes are generated from the two most prominent neuroepithelial stem cell pools in the subpallium: the medial ganglionic eminence (MGE) and the lateral/caudal ganglionic eminence (LGE/CGE). We will genetically tag and purify interneurons originating from these precursors in order to examine their transcriptomes and identify factors involved in specification and migration. We will use Cre-lox fate mapping in transgenic mice to label specific sub-populations of neural stem cells and their differentiated progeny in the embryonic telencephalon. This will allow us to determine whether subdomains of the MGE or LGE/CGE neuroepithelium generate interneurons with distinct neurochemical phenotypes and/or characteristic migratory properties. Electrical activity and/or neurotransmitter receptor activation can act in concert with genetic programs to promote precursor proliferation, neuronal differentiation as well as neuronal migration. We will use gain-of-function and loss-of-function approaches to examine the role of neurotransmitters and neuropeptides at early stages of interneuron migration to the cortex.

Keywords: mouse molecular genetics,cell migraton,interneurons,cortex,fate-mapping
Mathematical Problems in General Relativity (MPGR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: United Kingdom
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2013-08-31
Duration (months): 60.0
Total project cost (EUR): 500000.0
EU funding (EUR): 500000.0
Participants: 1
Project status: CLOSED

The proposed project concerns the study of mathematical aspects of the general theory of relativity. Major unsolved problems in the area include the problem of nonlinear stability of black hole spacetimes and the problem of weak and strong cosmic censorship. Mathematically, these problems concern the global dynamics of solutions to the Einstein equations. Resolution of these problems is of fundamental importance both to our understanding of the nature of the theory of relativity and to our assessment of its validity. In previous work, I have addressed these problems either under symmetry reductions or in linearised settings. These studies have revealed much of the mathematical structure of the dynamics of the Einstein equations in the context of black holes. Further progress extending beyond symmetry or linearised theory now appears possible. A research programme with this as a goal will be outlined in the proposal.

Keywords: partial differential equations,einstein equations
A Genetics Approach to the Interval Timing Mechanism (GENETICS OF TIMING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-02-11
End date: 2011-02-10
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Forward genetics has led to major advances in our understanding of the cellular and molecular mechanism of the circadian clock but there is no comparable understanding of the interval timing mechanism, which enables us to estimate durations and intervals between events. This is unfortunate because the ability to anticipate recurring events is essential for an orgranism’s survival. In this project, we propose an investigation of the neurobiological processes underlying interval timing using two approaches. First, we will use a reverse genetics approach to investigate the role of synaptic plasticity in timing. There is increasing evidence that interval timing involves dopamine modulation of cortico-striatal loops. However, no studies have tested whether synaptic plasticity is necessary for this process. We will address this question by testing mice with whole-brain or area-restricted mutations of the CaMKII gene on a timing task. CaMKII is required for plasticity in many areas of the brain, thus the mutation should interfere with temporal estimation if plasticity is involved in this process. Our second strategy follows a forward genetics approach, similar to the one pioneered by Seymour Benzer when he revealed the molecular machinery of the circadian clock. In our case, we will incorporate a timing task in the battery of automated screens used by NeuroBsik, a consortium, of which the Host is a member, engaged in large-scale phenotyping of mutant mice. These mice have random but easily identifiable mutations. This will allow us to discover new genes that are involved in interval timing.

Keywords: interval timing,genetics,synaptic plasticity,camkii,mutant mice
A study of the spontaneous and evoked spindle activity in schizophrenic and control subjects (SPINDLESINSCHIZO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2009-03-01
End date: 2013-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Understanding the pathophysiology of schizophrenia is one of the most compelling challenges facing current psychiatric research. Several electrophysiological and neuroimaging studies have explored the brain activity of schizophrenics and controls while these subjects performed various cognitive tasks to identify brain abnormalities specific for schizophrenia. In this study, schizophrenics and controls will be investigated while asleep. Sleep EEG recordings minimize possible waking-related confounding factors, including level of attention and presence of psychotic symptoms, and offer the opportunity to study sleep-specific rhythms such as sleep spindles. In a recent study with a 256 channel high density EEG (hd-EEG), Ferrarelli et al. (AJP 2007) revealed that schizophrenics (n=18) had a significant reduction in several spindle parameters in a centroparietal area compared to controls (n=17) during the first sleep episode. Other recent studies by Massimini et al. have demonstrated the feasibility of combining TMS with hd-EEG to investigate changes of effective connectivity in healthy subjects between waking and sleep (Science 2005, PNAS in press). In this study, hd-EEG recordings will be performed in schizophrenics and controls with two aims: 1) studying spontaneous brain activity, particularly spindles, during sleep 2) exploring the dynamics of evoked responses during sleep, especially the modulation of spindle activity following an evoked potential. Hd-EEG will be used to assess the stability of the spindle pattern over time and to investigate larger groups, including patients without schizophrenia taking antipsychotics. Evoked activity during sleep will be explored using both auditory tones and TMS to induce slow oscillations or K-complexes, which are often followed by spindles. It is expected that a comprehensive investigation of spontaneous and evoked spindle activity will provide a parameter which minimizes the overlap between schizophrenics and controls.

Keywords: health sciences,neurosciences,neurobiology,schizophrenia,sleep spindles,biological marker,high-density eeg,tms
Bioapplications of Metal Organic Frameworks (BIOMOFS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-06-01
End date: 2013-05-31
Duration (months): 60.0
Total project cost (EUR): 1902218.4
EU funding (EUR): 1250000.0
Participants: 1
Project status: CLOSED

This project will focus on the use of nanoporous metal organic frameworks (Fe, Zn, Ti) for bioapplications. These systems are exciting porous solids, built up from inorganic clusters and polycarboxylates. This results in open-framework solids with different pore shapes and dimensions, and applications such as catalysis, separation and storage of gases. I have recently initiated the synthesis of new trivalent transition metal carboxylates. Among them, the metal carboxylates MIL-100 and MIL-101 (MIL: Materials of Institut Lavoisier) are spectacular solids with giant pores (25-34 Å), accessible metal sites and huge surface areas (3100-5900 m2.g-1). Recently, it was shown that these solids could be used for drug delivery with a loading of 1.4 g of Ibuprofen per gram of MIL-101 solid and a total release in six days. This project will concentrate on the implication of MOFs for drug release and other bioapplications. Whereas research on drug delivery is currently focused either on the use of bio-compatible polymers or mesoporous materials, our method will combine advantages of both routes including a high loading and a slow release of therapeutic molecules. A second application will use solids with accessible metal sites to coordinate NO for its controlled delivery. This would provide exogenous NO for prophylactic and therapeutic processes, anti-thrombogenic medical devices, improved dressings for wounds and ulcers, and the treatment of fungal and bacterial infections. Finally, other applications will be envisaged such as the purification of physiological fluids. The project, which will consist of a systematic study of the relation between these properties and both the composition and structure of the hybrid solids, will be assisted by a strong modelling effort including top of the art computational methods (QSAR and QSPKR). This highly impact project will be realised by assembling experienced researchers in multidisplinary areas including materials science, biology and modelling. It will involve P. Horcajada (Institut Lavoisier), whose background in pharmaceutical science will fit with my experience in inorganic chemistry and G. Maurin (Institut Gerhardt, Montpellier) expert in computational chemistry.

Keywords: metal-organic-framework,drug delivery,computer simulation,porous solids,biology
A novel class of genetically encoded sensors of membrane protein function and structure (MEMSENSORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2007-09-01
End date: 2010-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The discovery of the green fluorescent protein (GFP), and its applications have revolutionized many fields of life sciences. The GFP (and other fluorescent proteins, XFPs) have now been used as a basis for development of optical sensors of a wide range of cellular properties and processes. In order to convert changes in cellular properties into an optically detectable signal, the currently used probes exploit only one mechanism: environment-induced changes of the optical properties of the fluorophore Our theoretical work suggests that another class of probes exists, and provides the theoretical background for development and use of these probes. The new class of probes utilizes the fact that the XFP fluorophore is planar, and thus its optical properties are anisotropic. If the anisotropic XFP fluorophore is anchored to non-centrosymmetric support, such as to the cell membrane, under the right conditions even small changes in fluorophore orientation should lead to pronounced changes in observed fluorescence. Our experimental work on development of a voltage-sensitive fluorescent protein (VSFP) provides preliminary evidence for existence and usability of this phenomenon. It is the goal of the proposed work to test the hypothesis that fluorophore anisotropy can serve as a basis of a range of genetically encoded sensors of membrane protein activity and structure. To test this hypothesis we aim to (1) prove that the observed fluorescence changes in our VSFP constructs are due to changes in fluorophore orientation; (2) deduce information about the structure of our VSFP construct from our fluorescence imaging data; and (3) apply our methods to other proteins. The new mechanism of transduction of conformational changes to changes in fluorescence should lead to an improved VSFP, and to development of a number of genetically encoded reporters of activity and structure of membrane proteins, with a large scientific impact.

Keywords: cell biology,molecular design,de novo design,molecular biology,neurobiology
The formation of Islam: The view from below (FOI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Cultures and cultural production
Countries involved: Netherlands
Call:  (ERC-2007-StG, 2007)
Start date: 2009-03-01
End date: 2015-02-28
Duration (months): 72.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: CLOSED

My project is to write a history of the formation of Islam using the vastly important but largely neglected papyri from Egypt. Until the introduction of paper in the 10th C., papyrus was the Mediterranean world’s primary writing material. Thousands of papyrus documents survive, preserving a minutely detailed transcription of daily life, as well as the only contemporary records of Islam’s rise and first wave of conquests. As an historian and papyrologist, my career has been dedicated to developing the potential of this extraordinary resource. The prevailing model of Islam’s formation is based on sources composed by a literary élite some 150 years after the events they describe. The distortions this entails are especially problematic since it was in these first two centuries that Islam’s institutional, social and religious framework developed and stabilised. To form a meaningful understanding of this development requires tackling the contemporary documentary record, as preserved in the papyri. Yet the technical difficulties presented by these mostly unpublished and uncatalogued documents have largely barred their use by historians. This project is a systematic attempt to address this critical problem. The project has three stages: 1) a stocktaking of unedited Arabic, Coptic and Greek papyri; 2) the editing of a corpus of the most significant papyri; 3) the presentation of a synthetic historical analysis through scholarly publications and a dedicated website. By examining the impact of Islam on the daily life of those living under its rule, the goal of this project is to understand the striking newness of Islamic society and its debt to the diverse cultures it superseded. Questions will be the extent, character and ambition of Muslim state competency at the time of the Islamic conquest; the steps – military, administrative and religious – by which it extended its reach and what this tells us about the origins and evolution of Muslim ideas of rulership, religion and pow

Keywords: papyrus,islam,documents,egypt,late antiquity
Societies of South Peru in the Context of Climatic and Environmental Change, Late Pleistocene to Modern Age – Rio Tambo Projekt (TAMBO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-04-01
End date: 2012-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The project, Societies of South Peru in the Context of Climatic and Environmental Change, Late Pleistocene to Modern Age (Rio Tambo Project), is intended – basing on research made in the valley of Rio Tambo and the adjacent coastal zone– to present an analysis of climatic and environmental change at work in the region of S. Peru starting from late Pleistocene until present and the impact of these changes on the character of human settlement. Apart from tracing the process of adaptation of human groups inhabiting the region to gradual global shifts of climate and vegetation the project is expected to help in determining the impact of on smaller scale seasonal shifts in climate (short-lived from the perspective of climatology), only regional or local in impact. The main source of climatic impact on a regional scale has been El Niño which influenced processes of settling and withdrawal of human settlement in specific areas of the valley and the ocean coast. Local-scale impact (limited in range) is primarily associated with seismic and volcanic phenomena which are noted with special intensity in the southernmost part of Peru, ie, in the region of the proposed research. The proposed research is interdisciplinary in character and envisions close cooperation of a wide range of specialists from the fields of climatology, palaeogeography and volcanology, as well as archaeologists, ethnologists and specialists from other fields, eg photogrammetry, C14 analysis and palaeobotany. The project will document from a chronological perspective climatic and environmental change in the study area, defining their parameters and reconstructing the stages of colonisation by human settlement and its decline in individual ecological enclaves; a phenomenon which is observed in Andean valley areas also in modern times.