Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Institutional, BEhavioural, critical and adaptive economics towards SustaInable Development, management of natural capital and circular Economy (BESIDE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal
Call: ERA Chairs (H2020-WIDESPREAD-2018-2020-6, 2019)
Start date: 2021-01-01
End date: 2027-06-30
Duration (months): 78.0
Total project cost (EUR): 2498621.25
EU funding (EUR): 2498621.25
Participants: 1
Project status: SIGNED

BESIDE aims to reinforce and consolidate at the University of Aveiro (UAVR) Associated Laboratory CESAM research expertise in Environmental Economics and Natural Resources (EENR). This will boost the existing fundamental and applied research activities by filling the identified gaps on: i) financial impact of environmental policies, ii) high-skilled jobs opportunities iii) circular economy business models. The ERA Chair will be hired for the position of Coordinator Researcher (full Prof equiv) and fund 5 researchers and 3 PhD students. CESAM has already 2 research positions in EENR and will support new advance training at MSc and PhD levels. BESIDE will be framed in 4 pillars i) institutional economics (how do institutions shape and constrain sustainable resources management); ii) behavioural economics (what is needed to provoke sustainable resources management); iii) critical economics (drawbacks and limits to as well as going beyond the ecosystem services approach); and iv) adaptive economics (model competitive advantages for existing and new businesses, and jobs). BESIDE is fully aligned with UAVR and CESAM goals and therefore in line with UN sustainable development goals for 2030, EU priorities that include the commitment for an intelligent, sustainable and inclusive growth based on knowledge and innovation and the shared pursuit of excellence, and with the national and Centro-Portugal region research and innovation strategies for smart specialisation (RIS3). The contribution of an external Scientific Steering Committee gathering EENR top experts, will be essential to its scientific success, while CESAM’s Stakeholders Consultation Committee, with some of the main Institutions and Business representatives at the National and Regional levels, will ensure that it is relevant to promote a more efficient use of environmental resources and a more competitive, resilient and sustainable economy; designed to endorse job creation and assure territorial and social cohesion

Keywords: ecosystem based management,resilience thinking,territorial and social cohesion,advanced training,sustainable development goals,climate strategies and targets,smart specialization,ecosystem service
THz Frequency Rapid Scan – Electron Spin Resonance spectroscopy for spin dynamics investigations of bulk and surface materials (THz-FRaScan-ESR) (THz-FRaScan-ESR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany,Czechia
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1999874.0
EU funding (EUR): 1999874.0
Participants: 2
Project status: CLOSED

Current high frequency electron spin resonance (HFESR) instruments suffer from the disadvantages of being limited to a single frequency and to tiny sample volumes. The study of spin dynamics at frequencies beyond a few hundred gigahertz is currently prohibitively difficult. These limitations are now preventing progress in dynamic nuclear polarization (DNP) and preclude the implementation of zero-field quantum computing. In order to revolutionize sensitivity in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) by means of DNP techniques allowing to watch in real time molecular interactions or even to monitor how sophisticated systems (ribosomes) work, the HFESR methods have to be substantially improved. I will develop a novel and worldwide unique technique called broadband terahertz frequency rapid scan (FRaScan) ESR. I intend to implement this method into a working prototype, which will seamlessly span the entire frequency range from 100 GHz to 1 THz, and allow spin dynamics investigation of large samples. This revolutionary new concept based on rapid frequency sweeps will remove all the restrictions and limitations of conventional HFESR methods used nowadays. It will enable for the first time multi-frequency studies of quantum coherence also in zero magnetic field. It will lead to substantial increases in sensitivity and concurrent decrease of measurement time, thus allowing more efficient use of resources. Finally, the method will allow identification of novel DNP signal enhancement agents, ultimately leading to a step change improvement of the MRI method. It will drastically shorten MRI scan times in hospitals, greatly enhancing patient comfort together with significantly better and precise diagnoses. The method will lead to zero field quantum computers with computation power which will be never reached with conventional technology. In summary it will lead to impacts far beyond the scientific community.

Keywords: electron spin resonance esr spectroscopy,spin dynamics,dynamic nuclear polarization
Life without mitochondrion (Amitochondriates)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Czechia
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2023-12-31
Duration (months): 68.0
Total project cost (EUR): 1935500.0
EU funding (EUR): 1935500.0
Participants: 1
Project status: SIGNED

Mitochondria are often referred to as the “power houses” of eukaryotic cells. All eukaryotes were thought to have mitochondria of some form until 2016, when the first eukaryote thriving without mitochondria was discovered by our laboratory – a flagellate Monocercomonoides. Understanding cellular functions of these cells, which represent a new functional type of eukaryotes, and understanding the circumstances of the unique event of mitochondrial loss are motivations for this proposal. The first objective focuses on the cell physiology. We will perform a metabolomic study revealing major metabolic pathways and concentrate further on elucidating its unique system of iron-sulphur cluster assembly. In the second objective, we will investigate in details the unique case of mitochondrial loss. We will examine two additional potentially amitochondriate lineages by means of genomics and transcriptomics, conduct experiments simulating the moments of mitochondrial loss and try to induce the mitochondrial loss in vitro by knocking out or down genes for mitochondrial biogenesis. We have chosen Giardia intestinalis and Entamoeba histolytica as models for the latter experiments, because their mitochondria are already reduced to minimalistic “mitosomes” and because some genetic tools are already available for them. Successful mitochondrial knock-outs would enable us to study mitochondrial loss in ‘real time’ and in vivo. In the third objective, we will focus on transforming Monocercomonoides into a tractable laboratory model by developing methods of axenic cultivation and genetic manipulation. This will open new possibilities in the studies of this organism and create a cell culture representing an amitochondriate model for cell biological studies enabling the dissection of mitochondrial effects from those of other compartments. The team is composed of the laboratory of PI and eight invited experts and we hope it has the ability to address these challenging questions.

Keywords: mitochondrion,iron sulphur cluster assembly,protists,oxymonads,giardia,entamoeba,mitosome,endosymbiosis
Arthroscopic Regenerative Medicine for Early-Stage Treatment of OA (ARMOURY)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Osteoarthritis (OA) affects about 10% of the global population. It has a major impact on a patient’s quality of life; with pain and physical function being worse than chronic obstructive pulmonary disease or even cardiovascular disease. Its prevalence is increasing, by 2020 it will be the 4th leading cause of disability. OA is caused by ‘wear and tear’ and currently only symptoms are treated using pain killers until major surgery is needed, then the joint is replaced. Although joint replacements have improved and often last over 30 years, they do fail with about 10% of all joint replacement operations being to fix a failed implant. In this project JRI is working with University Medical Center Utrecht (UMCU), The Netherlands and the Cell and Gene Therapy Catapult (CGT), UK, to develop a new treatment of OA in the hip and take it to market. This involves catching the disease early when it appears as a distinct lesion. JRI has developed Hummingbird, a system that can get into the complex anatomy of the hip and precisely cut out patches of diseased tissue. Then treating these patches with a cell-based treatment developed by UMCU and successfully used to treat OA in the knee. JRI believes that this treatment can be provided at a competitive price and at a scale to meet the global market. However, to do this they will need to build a robust business case and define in detail the regulatory pathways to the markets in Europe and USA. They will do this by working with CGT. This Feasibility Study is the first phase of this work. With CGT, JRI will define: the regulatory pathway, the cost of providing the treatment, the reimbursement methods and the likely market share. The second phase will be in the first-in-human study and a critical step in both meeting the regulations and defining the benefits to this cell-based treatment being applied to the hip. This treatment may not cure OA, but should delay major joint surgery and, in time, may allow some to avoid it all together.

Keywords: arthroscopy,osteoarthritis,early stage treatment
Rehabilitation Hub: The World’s first Digital Recovery Therapy solution (ReHub)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2021-02-28
Duration (months): 33.0
Total project cost (EUR): 1512122.5
EU funding (EUR): 1058484.75
Participants: 1
Project status: CLOSED

Over 100M people in Europe suffer from chronic musculoskeletal disorders (MSD) such as rheumatoid arthritis, neck, lumbar and shoulder pain. However, the standard rehabilitation protocol is expensive and ineffective – our work in Phase 1 confirmed that the majority of rehabilitation programmes are not followed consistently and a staggering 80% of patients abandon their treatment prematurely, increasing likelihood of reinjure. To solve this problem, Bio-Sensing Solutions has dedicated the past 3 years to developing our DyCare® ReHub tele-rehabilitation solution that offers support for diagnosis and delivers effective, personalised therapy for MSD sufferers. With our proprietary wearable sensor and intelligent algorithms, physiotherapists will, for the first time, be able to create a rehabilitation programme based on objective measurements of a patient’s muscle strength and joint movement, whilst monitoring their progress remotely, adjusting the exercises on the fly if needed. For the patient, ReHub guides them through each custom-tailored home exercise and empowers them with real-time performance biofeedback. And, with an innovative B2B2C business model, the Physician, Physiotherapist and Patient can stay connected via an easy-to-use online platform. We have validated our first prototype in 3 leading health centres, placing our innovation at TRL 7. ReHub has shown to reduce patient recovery time by 40%, boost rehab completion to 90% and increase health centre productivity by 60%. We aim to become leaders in the 4 B€ MSD rehabilitation market in Europe. We are requesting SME Instrument Phase 2 funding to optimise ReHub core algorithms, industrialise our hardware components and validate performance in 2 large-scale clinical studies. By 2022, we expect to sell a total of 1,239 ReHub licenses and reach 165k patients, growing our team to 26 skilled professionals and company revenues to 13.8 M€.

Keywords: rehabilitation,musculoskeletal disorders,digital health,neurology,phisiotherapy,phisician,physical rehabilitation,wearable device
Electro-thermal modelling of lithium-ion battery packs from the safety perspective (SAFE LIB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-16
End date: 2017-11-15
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Lithium-ion batteries (LIB) are found in many applications such as consumer electronics, electric vehicles and airplanes. However, LIBs can be dangerous under some conditions and can pose a safety hazard since they contain a flammable electrolyte and are also kept pressurized. Despite the high safety standards being imposed and the embedded safety features, there have been many reported accidents as well as recalls done by some companies. Most accidents can be sourced to run away reactions, which could happen if the LIBs are overheated or overcharged. This is often accompanied by cell rupture and in extreme cases can lead to fire and explosions. The Fellow has conducted her PhD on LIB run away reactions and investigated the effect different anode and cathode materials to enhance LIB safety through modelling, experiments and theoretical study of LIB cell. She will transfer such knowledge to the European host and combine with their extensive expertise in fire and explosion modelling to develop a thermal model to simulate the heat generation and dissipation within the battery pack. The research intends to bridge some important knowledge gaps concerning LIB safety and deliver a predictive tool, which can be used to enhance LIB thermal management from the safety perspective. Such a tool can aid the development of safer LIB cells and the optimisation of LIB packs balancing performance and safety requirement. The specific objectives include: - Develop and validate a thermal model that will predict the onset of runaway reactions (WP1); - Extend the above model to predict potential ignition (WP2); - Further extend the model to predict possible escalation from a single cell ignition to potential fire and explosion hazards (WP3); - Validate the predictions with full scale test data giving particular emphasis to cell rupture and the propensity from ignition of a single cell to battery packs (WP4); and - Conduct cases studies to formulate recommendations on LIB safety.

Keywords: lithium ion battery,thermal runaway,fire and explosion,electro thermal modelling,computational fluid dynamics cfd
Fast and Reliable Symbolic Computation (FRESCO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 1999926.0
EU funding (EUR): 1999926.0
Participants: 1
Project status: SIGNED

The use of computers for formulating conjectures, but also for substantiating proof steps, pervades mathematics, even in its most abstract fields. Most computer proofs are produced by symbolic computations, using computer algebra systems. Sadly, these systems suffer from severe, intrinsic flaws, key to their amazing efficiency, but preventing any flavor of post-hoc verification. But can computer algebra become reliable while remaining fast? Bringing a positive answer to this question represents an outstanding scientific challenge per se, which this project aims at solving. Our starting point is that interactive theorem provers are the best tools for representing mathematics in silico. But we intend to disrupt their architecture, shaped by decades of applications in computer science, so as to dramatically enrich their programming features, while remaining compatible with their logical foundations. We will then design a novel generation of mathematical software, based on the firm grounds of modern programming language theory. This environment will feature a new, high-level, performance-oriented programming language, devised for writing efficient and correct code easily, and for serving the frontline of research in computational mathematics. Users will have access to fast implementations, and to powerful proving technologies for verifying any component à la carte, with high productivity. Logic- and computer-based formal proofs will prevent run-time errors, and incorrect mathematical semantics. We will maintain a close, continuous collaboration with interested high-profile mathematicians, on the verification of cutting-edge research results, today beyond the reach of formal proofs. We ambition to empower mathematical journals to install high-quality artifact evaluation, when peer-reviewing falls short of assessing computer proofs. This project will eventually impact the use of formal methods in engineering, in areas like cryptography or signal-processing.

Keywords: computer algebra
Services based on Ecosystem data AssiMiLation: Essential Science and Solutions (SEAMLESS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Norway,France,France,Denmark,United Kingdom
Call: Copernicus evolution: Research activities in support of the evolution of the Copernicus services (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1499851.25
EU funding (EUR): 1499851.25
Participants: 7
Project status: SIGNED

The ocean provides us with vital climate and food services by absorbing 30% of anthropogenic carbon emissions and supplying 17% of animal proteins to the world’s population. However, we are still far from accurately estimating these services using the state-of-the-art operational models at the Copernicus Marine Environment Monitoring Service (CMEMS) Monitoring and Forecasting Centres (MFCs). The main aim of SEAMLESS is to provide CMEMS MFCs with unprecedented capabilities to deliver indicators of climate-change impacts and food security in ocean ecosystems, such as particulate carbon export and plankton phenology. The central hypothesis of SEAMLESS is that new ensemble data assimilation methods can better estimate crucial ecosystem indicators by integrating the new generation of European Copernicus satellite observations and in-situ ocean data. Specifically, our approach will link coherently biogeochemical and hydrodynamic simulations. The hypothesis is supported by our previous work, in which we improved the MFCs’ model simulations of the plankton stocks at the base of the marine food web by assimilating biogeochemical and physical data from satellites, Biogeochemical-Argo floats and gliders. SEAMLESS will develop a new assimilation prototype that will expand simulations to plankton dynamics and related biogeochemical processes, e.g., plankton phenology and carbon export. This prototype will be disseminated to CMEMS stakeholders and the wider oceanographic community. To guarantee the integration of SEAMLESS into CMEMS, we have assembled a team with outstanding expertise and track records for all the key project components, which includes CMEMS MFC core developers, and will be supported by policy, blue-growth and academic stakeholders. On project completion, six CMEMS MFCs will be able to add new and improved products on water quality, carbon cycle and trophic webs to their portfolios, ultimately allowing users to exploit more sustainably ocean ecosystem services.

Keywords: cmems,marine ecosystem indicators,ensemble data assimilation da,copernicus sentinel,ocean colour,biogeochemical argo,operational oceanography,carbon cycle,food security,water quality