Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The chemistry and physics of RNP granules: how they form, age and cause disease (PhaseAge)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2024-03-31
Duration (months): 84.0
Total project cost (EUR): 1931303.0
EU funding (EUR): 1284801.06
Participants: 2
Project status: SIGNED

Recent studies suggest that defective ribonucleoprotein (RNP) granules and altered RNA processing cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, defective RNP granules only develop late in life, suggesting that young cells have mechanisms in place to prevent their formation. We recently demonstrated that physiological RNP granules form through phase separation in the cytoplasm and adopt a liquid-like state, but with time transition into an aberrant disease-associated state with solid material properties. Focussing on this conceptual advance, we will 1) investigate the molecular mechanisms of RNP granule formation; 2) pinpoint the molecular events that lead to aberrant RNPs, focusing on disease-associated mutations, changes in environmental conditions, post-translational modifications and molecules with fluidizing or solidifying effects; and 3) define the mechanisms of RNP quality control, which prevent aberrant phase transitions or reverse RNP aggregates to their normal state, thus rescuing a cell from an otherwise fatal condition. Key to the project are recently developed methodologies to reconstitute RNPs from purified proteins and RNAs, and biophysical techniques to analyse the material properties of RNP granules. Combined with our ability to perform time-resolved studies of RNPs in living cells and our thematic focus on the link between RNP dynamics and functionality, this project represents a systematic and realistic approach to tackling the essential question of how RNP granules form and why they cause disease. We expect that our findings will have impact far beyond ALS and FTD, because aberrant phase transitions may be at the heart of many protein-misfolding diseases. We envision that our findings will lead to new therapeutic interventions that may significantly improve the prospects of patients afflicted with these diseases.

Keywords: rnp granules,rna metabolism,phase transition,protein aggregation,proteostasis,aging,neurodegenerative disease
Novel Personalized Cellular Therapy Approach for Immune Diseases (TLA-Gut)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-07-01
End date: 2023-03-31
Duration (months): 57.0
Total project cost (EUR): 3850000.0
EU funding (EUR): 2695000.0
Participants: 1
Project status: SIGNED

This project will commercialise TLA Gut - the novel medical device for the treatment of Inflammatory Bowel Disease (IBD). IBD belongs to the group of Immune Mediated Inflammatory Diseases (IMIDs) caused and maintained by an exaggerated inflammatory response triggered by an imbalance of the immune system. Research at Karolinska Institutet in Sweden has shown that IMIDs are caused by increase in specific inflammatory cells, which migrate to the site of inflammation by chemotaxis and induce disease-causing inflammation through release of cytokines in tissues. TLA Gut is a globally unique technology, and the first medical device with a proven clinical efficacy in removing those disease-causing cells from the blood of the patient through therapeutic leukapheresis. Today, the development and commercialisation of new therapies for IBD is in great demand among clinicians and their patients as current treatments offer an overall long-term remission rate of only 50-60% and carry the risk of life-threatening side effects. There exists a strong business opportunity for a therapy that would create a new and personalized way to treat IBD. TLA Gut is positioned to satiate this demand. To date, TLA Gut in vivo proof of concept has been established in a Phase I/II clinical trial on IBD patients in Stockholm. In the project, the Phase III study will be performed together with regulatory development work required to get market access upon completion of the project. IBD poses a significant socio-economic burden internationally. In Europe, a direct healthcare cost of IBD is estimated to € 4.6–5.6 billion per year. Once introduced in the clinical praxis across the EU, TLA Gut will be a safe and cost-efficient treatment option for IBD patients. The overall business strategy of TLA is aligned to close the remaining clinical and regulatory gap to the market for TLA Gut and commercialise the medical device. The project is the key enabler of this strategy.

Keywords: therapeutic leukapheresis,immune mediated inflammatory diseases,inflammatory bowel,disease,removal of disease causing cells
A novel and versatile 3-tower maritime structure for the cost-efficient installation of all-sizes offshore wind turbines. (TRIWIND)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The TRIWIND project is the result of a project initiated by Berenguer Ingenieros one year ago, which has resulted in a patented technology (application number: P201631043) for the cost-efficient installation of offshore wind farms. Following the R&D stage already accomplished and the patent application, the ultimate goal we seek in the project is to complete the prototyping stage and testing studies to reach its commercial appetite and value for leading companies of the wind energy sector such as Siemens and MHI Vestas, which account for more than 80% of the wind turbine manufacturers market share only in Europe. This is an innovative foundation solution for offshore wind turbines that directly impacts on (1) production costs reducing on circa 30%; (2) on transportation (self-buoyant) and installation (self-installed) with a combined costs savings of 86.5% and operational average time reduction from 12-20h to 3h and; (3) it also affects on the decommissioning phase by 50% reduction. All these costs savings represent circa 16.7% of the total costs of an offshore wind turbine life-cycle. Other crucial aspects are related to structure’s duration extension and less maintenance requirements, technical and operational easiness in all previous phases along with health and safety improvements. For this phase 1, we will perform a feasibility study including: (1) technical feasibility, 2) operational/financial feasibility and 3) commercial feasibility.

Keywords: off shore wind energy,renewable energy
TRANSLATION INITIATION CONTROL IN PLANTS: THE ROLE OF TOR (TARGET OF RAPAMYCIN) (TOR in acTIon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Translation is a critical step in the regulation of gene expression in eukaryotes. Most of the control occurs at the level of translation initiation, which is a rate-limiting step in protein synthesis. In mammals, cap-dependent translation initiation is under the regulation of the target of rapamycin (TOR) protein kinase, which suppresses the function of translation repressor proteins, the eIF4E-binding proteins (4E-BPs) that sequester the cap-binding factor eIF4E at the 5′-end of mRNA. The TOR signaling pathway integrates nutrient and energy sufficiency, hormones and growth factors to regulate protein synthesis in mammals and plants. How TOR signals environmental changes to regulate mRNA translation and ribosome production in plants is at present unknown. This project aims to define the role of the plant TOR kinase in translation regulation and to understand how plants have rewired the TOR signalling pathway for their specific translational programs. We have discovered putative plant translation repressor (TR) proteins that harbour eIF4E binding sites and TOR phosphorylation sites, and will study translation initiation mechanisms and their control by TOR in the shoot apical meristem—a specialized tissue containing a stem cell niche responsible for building the shoot. The main objective of proposed research is to uncover regulatory factors that function under the control of TOR in translation initiation and to identify their targets among meristematic mRNAs. A search for cellular mRNAs whose initiation is regulated by TOR and/or TR proteins will be performed using a global ribosomal profiling approach. The plant hormone auxin is an upstream effector of TOR and impacts stem cell niche activity. Thus, we shall study whether TOR mediates signaling from auxin to control TR activity and translation initiation. Finally, we will test whether TOR couples amino acid sensing to regulation of translation initiation.

Keywords: translation initiation control,cap binding protein factors,plant stem cells,meristems,target of rapamycin
QBeast Utility Analysis to marKet and Enterprise (Quake)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Spain
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2017)
Start date: 2018-04-01
End date: 2019-09-30
Duration (months): 18.0
Total project cost (EUR): 99750.0
EU funding (EUR): 99750.0
Participants: 1
Project status: CLOSED

As a result of HBP SGA-1, the Qbeast framework enables to achieve the concept of interactive supercomputing and in-situ techniques to break traditional workflows in HPC simulations, converting them into more dynamic and adaptive to the needs of scientists. As a long term project, the HBP does not include in its current work plan the exploitation of such relatively small research pieces developed in the project, which could cause loosing exploitation opportunities, as we believe it is the Qbeast case. The QUAKE project proposes to solve the lack of early exploitation in the HBP by moving Qbeast to the market. While in the HBP the focus was the neuroscience community, Qbeast is a traversal tool and can be applied to many different domains, including Computational Fluid Dynamics (CFD) (automotive, wind energy, …), molecular dynamics simulations (pharmaceutical), geological prospections (oil) or weather forecasting (civil emergencies). We see good opportunities for Qbeast in both the BioTech and the Business Intelligence markets. For the former, we have a prototype available that can be used to directly explore outreach in the BioTech market. For the latter, we see Qbeast as a tool that can be disruptive in the BI market due to its scientific innovations. The high level objectives of this project are (1) to develop a clear understanding of the potential markets for our technology, (2) to develop a prototype as a demonstrator for BI market outreach while exploiting our available prototype for the BioTech sector and (3) to ultimately create a comprehensive business plan that will outline the relevant steps required to launch our technology to the market through the creation of a spin-off company.

Keywords: multidimensional indexing,nosql,market analisys,spin off creation,qbeast
PROTECTion against Endocrine Disruptors; Detection, mixtures, health effects, risk assessment and communication. (PROTECTED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: India,Spain,Norway,Belgium,Belgium,Norway,France,Netherlands,United Kingdom,Chile,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3974594.76
EU funding (EUR): 3974594.76
Participants: 13
Project status: CLOSED

PROTECTED aims to develop expertise and protective capabilities against Endocrine Disruptors (EDs). EDs and their mixtures are a modern day health concern leading to failing ecological systems, poor agricultural production and health effects such as obesity, cancer and infertility. While analytical methods have advanced enormously, focus has been mainly on synthetic chemicals, overlooking emerging EDs and real-life multiple substance exposure. A new generation of creative, entrepreneurial and innovative early-stage researchers equipped with skills to assess and understand the real-life risk of complex mixtures of EDs and trained to convert resulting knowledge and ideas into accessible tools and services for the long-term control of potential ED risk is urgently needed. The PROTECTED Innovative Training Network [ITN] proposes a holistic approach by providing 15 individual, personalised research projects with exposure to scientific, innovative and entrepreneurial training mobility across the ITN. The intersectorial network is comprised of 12 training sites at academia, research centres, a bioassay technology SME, a QSAR technology SME, water provider, and animal feed supplier. Together they cover multiple disciplines including analytical science of food, feed, and environment, epidemiology, risk assessment, social science and toxicology. This combined expertise enables a highly focused program for developing novel tools and concepts and training for the detection, analysis and improved risk assessment of EDs, especially mixture effects. Methodology will include emerging technologies; multiplexed analysis, mixture modelling, mechanistic and exposure studies, explants and cell or whole organism bioassays. The project will provide a unique and high level of training for a new generation of specialists with transferable skills and enhanced career perspectives. These specialists will ultimately aid the efficient development of future control strategies for improved health.

Keywords: endocrine disruptors,mixtures,toxicology,food chain,risk assessment,public health
Mid-InfraRed Streak Camera (MIRed Streak)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2021-06-30
Duration (months): 36.0
Total project cost (EUR): 232160.4
EU funding (EUR): 232160.4
Participants: 2
Project status: CLOSED

Understanding matter on its fastest timescales is of major interest in order to answer fundamental questions in physics, chemistry and biology. With the advent of attosecond pulses (1as=10^-18s), atoms, molecules and solids can be deeply excited in a quasi-instantaneous manner leading to ultrafast processes. While electrons can respond to the excitation in only a few-10as to a few tens of femtoseconds (fs), nuclear motions take place in a few-fs to picoseconds (ps). The real challenge is how to probe those dynamics when they are strongly coupled. Attosecond streaking (one attosecond pulse to excite the system, one infrared fs pulse to probe the dynamics) is the most accurate temporal metrology ever implemented. Sub-10as delays have been measured with the accuracy of only a few attoseconds. However, the window of observation is limited to the half optical period of the probe pulse and only dynamics on the fs-timescale can be time-resolved. On the other hand, using a terahertz field as a probe offers a wider window of observation of the ps, but with a low resolution of ~10fs. Unfortunately, vibronic dynamics in which nuclear and electronic motions are strongly coupled occur on an intermediate timescale of a few-fs. The objective of the MIRed Streak project is to develop an intense source of mid-infrared pulses (MIR, wavelength between 5 and 20 microns) to follow the couplings of electron and nuclei dynamics in polyatomic molecules over several 10fs with sub-100as accuracy. This project will provide a powerful novel tool to access a nonesuch insight of ultrafast processes in matter. After studying vibronic dynamics in simple molecules and probing isotopic and mass effects, the long-term objective is to investigate more complex systems such as amino acids and nucleobases, which play an essential role e.g. in the photoprotection of DNA to UV light. Understanding vibronic dynamics will provide a deep insight into the nature of chemical bonds.

Keywords: attosecond science,ultrafast molecular dynamics,mid infrared generation,nonlinear optics,high harmonic generation,core shell photoexcitation of bromine based molecules,pump probe spectroscopy
Towards coordinated microbiome R&I activities in the food system to support (EU and) international bioeconomy goals (MicrobiomeSupport)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Ireland,Italy,Australia,India,South Africa,Argentina,Austria,Germany,Germany,Germany,Spain,Austria,Austria,Belgium,Greece,New Zealand,Poland,China,France,Netherlands,United States,Canada,Brazil,United Kingdom,Denmark
Call: Supporting microbiome coordination and the International Bioeconomy Forum (H2020-SFS-2018-1, 2018)
Start date: 2018-11-01
End date: 2022-10-31
Duration (months): 48.0
Total project cost (EUR): 3590466.25
EU funding (EUR): 3520466.25
Participants: 31
Project status: CLOSED

The proposed Coordination and Support Action (CSA) has the overall objective to establish an international network of experts and stakeholders in the field of microbiome food system research, elaborating microbiomes from various environments such as terrestrial, plant, aquatic, food and human/animal and assess their applicability and impact on the food system. MICROBIOMESUPPORT will follow the approach of food system and integrate actors and experts from all stages in this circular economy of food. The food system approach is part of the FOOD 2030 concept to promote a systems approach to research and innovation (R&I). MICROBIOMESUPPORT will be one of the key drivers to implement FOOD 2030 strategies, will facilitate multi-actor engagement to align, structure and boost R&I in microbiome and will support the European Commission by coordinating the activities, meetings, workshops and results from the International Bioeconomy Forum (IBF) working group ‘Food Systems Microbiome’. The main concept behind MICROBIOMESUPPORT IS to boost the bioeconomy and the FOOD 2030 strategy, by focusing on the new avenues generated by microbiome R&I efforts. MICROBIOMESUPPORT WILL have a main impact on the coordination of commonly defined R&I agendas which will be incorporated into regional, national, European but also global funding programmes related to microbiomes in food systems. MICROBIOMESUPPORT will create a collaborative international network and integrate know-how in plant, terrestrial, animal, human and aquatic microbiome R&I as well as expertise in bioeconomy applications. MICROBIOMESUPPORT has integrated international partners form Brazil, Canada, South Africa, China, Argentina, Australia, New Zealand, India and USA in order to improve the international cooperation and coordination of common bioeconomy research programmes and set a basis for common microbiome R&I agendas.

Keywords: microbiome food systems,networking,international bioeconomy forum,cooperation,coordination
Mimbox - Greywater optimisation and microplastic mitigation for washing machines (MIMBOX)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Sweden
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-10-01
End date: 2023-03-31
Duration (months): 30.0
Total project cost (EUR): 2643750.0
EU funding (EUR): 1850625.0
Participants: 1
Project status: CLOSED

Microplastics are a huge source of pollution in our seas, with up to 1.5 million tons being released per year. This poisons the underwater ecosystem and even climbs back up in the food chain to affect human health (estimates show that we eat about 5 grams of plastic each week). Washing machines contribute to about 35% of this problem, in the form of the 700,000 pieces of synthetic microfibres found in the greywater of each wash. Our company Mimbly has designed the Mimbox, the first ever “plug-and-play” add-on device that can connect to any type of washing machine to capture the microplastics released during each wash, acting as a single barrier to retain microplastics as small as 50 microns from reaching the waterways. At the heart of its innovation is a self-cleaning filtering technology, of which we are in a patent process. The Mimbox also cuts up to 70% of water consumption by cleaning and recycling the greywater, as well as reduces in a 30% the energy consumed in water heating, all with unaltered quality in the wash results. Additionally, it includes a data service functionality for customers to optimise their wash cycles. Our first commercialisation of the technology is aimed at industrial washers and it is compatible with all brands, sizes and generations of washing machines. The Mimbox offers an attractive average payback period of 2.5-year during 11-year industrial washer lifetime, and it is the perfect compliance solution for upcoming regulations and customer’s environmental sustainability policy and brand. The EIC accelerator project will setup and run 15 B2B customer pilots with the Mimbox MVP and demonstrate their results to additional stakeholders. We will establish scalable manufacturing partnership and distribution channels and achieve all the certifications for market release and scale-up. Our technology is expected to be used for over 100,000 washers by 2025, saving more than 1,200 tons of microplastics and 23 million m3 of water.