Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scale-up of the Europe Startup Nations Alliance as a European Digital Infrastructure Consortium and a catalyst for a startup-friendly reform in Member States (ESNA II)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Coordination and support actions
Countries involved: Portugal
Call: European Startup Nations Standard (HORIZON-CL4-2024-ESNS-IBA, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: SIGNED

ESNA has been created in 2022 with the vision of “becoming a leading Entity for the EU agenda for entrepreneurship and contribute to bring Europe to the lead of global startup ecosystem” and the mission to “support the signatory countries and provide concrete support to policy makers in implementing the best policy practices outlined in the EU Startup Nations Standard”. Two years on, and the organisation is clearly on the path to achieve both its vision and mission. A formal entity has been created in Portugal to allow the start of activities, as a first-of-a-kind body which has grown in resources, skills and specially in adhesion of member states, counting today 19 countries as a strong and very representative majority of the signatory countries of the SNS, and with continued negotiations for the inclusion of further members. In terms of activities, ESNA has initiated its pivotal role of monitoring of SNS adoption, with the launch of the SNS Scoreboard, first as a Baseline in 2022 and then as a first annual report in 2023, and the start of a new policy lab to support countries accelerating SNS implementation through best practice benchmarking, sharing and exchange. These ESNA initial activities have been pivotal in helping EU member states moving beyond the aspirations of the political declaration and into concrete implementation and benefiting from a strong participation of ESNA's signatory members, as demonstrated by the 91% response rate to the SNS Scoreboard 2023 inquiry. But in spite of ESNA’s significant advancements in terms of Member State adhesion and activities, there is still a need for an evolution in terms of a legal framework which is better aligned with its truly European role, as well as consolidating the breadth of its activities, namely in the area of the SNS standards implementation monitoring and knowledge sharing, which are the core objectives being pursued through the current application.

Keywords: startups,scaleups,entrepreneurship,standards of excellence,edic
Heart Attack Monitoring Patch (HAMP) (HAMP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-16
End date: 2024-06-15
Duration (months): 24.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: CLOSED

Every year more than 60 million people live with Cardiovascular Disease (CVD), and more than 1.8 million people die as a result of CVD, accounting for 36% of all deaths. Among different types of CVD, heart attack and stroke are the leading cause of death in the EU. The recognized guidelines identify the first one hour after the onset of a heart attack as the golden hour to receive proper medical assistance and prevent death or damage to organs. Hence, there is a vital need for a compact and easy-to-use biosensing platform that can be used outside hospital settings by the patient or the ambulance staff for diagnosis of heart attack within the golden hour. NT-pro-BNP is a desirable biomarker due to its fast release kinetics, higher circulation levels and lower fluctuations. Although significant advances in NT-pro-BNP biosensors generations have been achieved, these face some serious limitations as most of them cannot be used outside hospital settings, requiring physical attendance of patients which leads to losing time (beyond the golden hour) and increased risk of death. In this project, I propose – for the first time – a wearable and wireless system for early and quick diagnosis of a heart attack outside the hospital setting. The Heart Attack Monitoring Patch (HAMP) that I propose here, is composed of an AC Electrokinetic (ACEK)-based fast-response label-free NT-pro-BNP biosensor, microneedles array for interstitial fluid sampling and data processing, and wireless communication circuits. Although the ACEK phenomenon is a well-established method for the design of rapid biosensors, this is for the first time that the ACEK effect is employed by a wearable biosensing system for high speed (less than a minute) and low LOD (below 1 pg/mL) detection. The HAMP has a compact and conformal structure that is easy to use and can be used when patients feel the first symptoms of a heart attack and results can be conveniently sent to the nearby hospitals within the golden hour.

Keywords: ac electrokinetic,wearable,biosensor,wireless communication,
MRI-based ID of the Vasculature across the Heart-Brain Axis (VascularID)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1852430.0
EU funding (EUR): 1852430.0
Participants: 1
Project status: SIGNED

Microvascular impairment is a hallmark of many of today’s most burdening diseases, including forms of ischemic heart disease, stroke, and dementia. It is also the most promising candidate to explain the link between cardiovascular and brain disease (so-called heart-brain axis). However, only histology provides comprehensive assessment of the microvasculature, and is rarely available in vivo as it requires invasive biopsy. The lack of early, non-invasive markers limits our pathophysiological understanding and crucially affects treatment success, as preventive intervention is the only successful clinical management strategy available. With a major leap in Magnetic Resonance Imaging (MRI) physics, I will address this need and develop VascularID, a fully non-invasive toolset for the quantitative assessment of cardiac and cerebral microvasculature. This non-invasive biopsy exploits microscopic magnetic fields around the vessels to obtain structural information about the microvasculature. It is contrast-free and resilient against field inhomogeneities and can, for the first time, be used in both the heart and the brain. Combined with a new generation of non-contrast perfusion MRI, VascularID will provide comprehensive functional and structural information. My approach will first be validated in a micro-printed 3D model of the vasculature. In vivo feasibility will be demonstrated in an animal model. Proof-of-principle studies with VascularID in a cohort of patients suffering from heart disease and a cohort of patients with cerebral small vessel disease will demonstrate the clinical feasibility. I will develop, validate, and disseminate VascularID for research and clinical use to enable groundbreaking insights into the smallest blood vessels. These insights are perfectly poised to provide the missing key to the vascular underpinnings of diseases that form the major burden to our health care system in the years to come.

Keywords: magnetic resonance imaging,mri,cardiac magnetic resonance,cmr,quantitative magnetic resonance imaging,qmr,myocardial tissue characterization,parametric mapping,microvascular imaging,vascular mri
From understanding to rational design of next-generation cancer therapies (subLETHAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands,Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 2499893.0
EU funding (EUR): 2499893.0
Participants: 2
Project status: SIGNED

Immunotherapy combined with cytotoxic and molecular therapies have entered centre stage as novel treatments for cancer. Despite this advance, toxicity and insufficient efficacy in many patients remain major obstacles and illustrate the need for therapy improvement based on a deeper understanding of the cellular damage and repair responses to drugs and immunotherapy. To overcome this roadblock, I propose a previously unappreciated approach by combining immunotherapy with cancer therapies at ultra-low, sublethal dose. We demonstrated that cytotoxic T cells induce sublethal membrane and DNA damage and oxidative stress which, when repaired, allows for tumor cell survival. However, when damage adds up, the tumor cell dies. I hypothesize that sublethal effects reveal novel vulnerabilities in cancer cells which can be exploited by complementary multi-targeted therapies at ultra-low dose which are nontoxic individually but, when combined, achieve lethality by an additive mechanism. Taking advantage of innovative microscopy, I aim to produce a catalogue of damages and repair types, and their combined effects in tumor cells. Single-cell analyses combined with advanced statistics and mathematical modeling will be used to derive the damage profile and duration of damage for each modality in tumor cells, yet without side effects towards immune effector cells. I will design algorithms for multi-targeted regimens to achieve additive damage, reduced repair, and death induction and validate them in immunotherapy models in vitro and in local and disseminated preclinical cancer in vivo. If resistance occurs, survival programs will be detected by single-cell transcriptomics and countered by orthogonal targeting. subLETHAL will 1) identify sublethal damage as the basis of cytotoxic therapy, 2) enable rational design of multi-targeted ultra-low dose additive regimens and advance 3) the understanding, efficacy and tolerability of chemoimmunotherapy for 4) rapid clinical translation.

Keywords: tumor immunotherapy,microscopy,mathematical modeling
Meta-stable Smart Metamaterials for Actively-controlled and Reversible Transition waves (Meta-SMART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Mechanical metamaterials play a crucial role in various applications, such as shape morphing, soft robotics, and logic elements. However, the control and guidance of transition waves within these materials have primarily been static. The Meta-SMART project aims to revolutionize this by actively controlling and guiding transition waves using piezoelectric and shape memory polymer-based multimaterial active switches integrated into metamaterial unit cells. Unlike traditional methods, Meta-SMART offers dynamic and reversible control, allowing the metamaterials to adapt autonomously and universally. To optimize these smart metamaterials, we will implement a machine learning-based inverse design strategy to determine their geometrical parameters. Fabrication will involve 3D printing, followed by experimental testing of transition wave control and guidance. This innovation promises to advance the industrial applications of mechanical metamaterials, offering adaptability to external forces and desired outcomes. Potential uses include controlled energy absorption and dissipation for airflow control in aircraft, selective energy absorption in protective surfaces, and even treatment of Parkinson’s disease. The Meta-SMART project represents a valuable opportunity to expand my expertise in smart materials and structures, enhancing my research profile through hands-on experience in testing and fabrication. Training activities such as TU Delft's teachers' training program, workshops on supervising research projects, and advanced courses in machine learning and 3D printing, will equip me with the skills needed for a successful academic career in the smart materials and structures field, aligning with my long-term goals.

Keywords: mechanical metamaterials,wave guide,ml based inverse design,piezoelectric materials
Improving and upscaling primary prevention of cancer by addressing childhood obesity through implementation research - the PREVENT approach (PREVENT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Greece,Sweden,Spain,Belgium,Ireland,Italy,Germany
Call: Improving and upscaling primary prevention of cancer through implementation research (HORIZON-MISS-2022-CANCER-01, 2022)
Start date: 2023-07-01
End date: 2027-06-30
Duration (months): 48.0
Total project cost (EUR): 7469250.0
EU funding (EUR): 7469250.0
Participants: 21
Project status: SIGNED

PREVENT improves upscaling of primary interventions for weight control management during childhood and adolescence to reduce cancer risks in adulthood. This relies on current evidence that relates excess body weight with increased cancer risk. Towards this end, PREVENT applies a series of implementation research actions in the following directions. First, it identifies barriers to current interventions and policies preventing them from upscaling to different geographical, socio-economic, and cultural settings. Then, it introduces new multi-actor and context-aware interventions along with new user engagement strategies to face the current upscaling bottlenecks; multi-actor in the sense that they target different types of users (e.g., students, family, educators, policymakers) and context-aware in the sense that PREVENT interventions are tailored to the specific implementation places (class, canteen, sports fields, labs, outside school). The PREVENT new policies are adapted, piloted, and scaled up within the schools’ communities of three European countries facing different epidemiological settings on childhood obesity, geographic, socio-economic and cultural attributes. The pilots are designed to be holistic end-to-end ecosystems, including users, medical professionals, policymakers, public authorities, and civil communities. They focus on the whole school communities of Greece, Sweden, and Spain-Catalonia, that is, PREVENT outreach to more than 3.3 million students, required for guideline provisioning, large-scale implementation, multi-parameter assessment, and scaling-up. Co-creation, active behavioral change, self-evaluation through user empowerment, motivational interviewing, social innovation, digital-assistive engagement, health apps, and multi-domain assessment are implementation research aspects of PREVENT to advance user acceptability and compatibility with existing policies, and thus improve sustainability and upscaling. This action is part of the Cancer Mission cluster of projects on "Prevention and Early Detection".

Keywords: upscaling of primary cancer prevention measures,childhood adolescence obesity related to cancer,multi parametric assessment
Buildings as Efficient Interoperable Formers of Clean Energy Ecosystems (WeForming)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Greece,Luxembourg,Belgium,Ireland,Israel,Portugal,Croatia,Spain,Germany,United Kingdom
Call: Smart-grid ready and smart-network ready buildings, acting as active utility nodes (Built4People) (HORIZON-CL5-2022-D4-02, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 11994576.26
EU funding (EUR): 8693363.25
Participants: 32
Project status: SIGNED

The WeForming project aims to change the paradigm of efficiently managing energy in buildings, paying special attention to their interaction with the energy ecosystem (energy networks and markets) by developing, deploying and demonstrating innovative solutions addressing (i) digital operation, management and maintenance and (ii) efficient and interactive energy processing for Intelligent Grid-interactive Efficient Buildings (iGEBs), able to operate intelligently in a multi-energy, multi-user, multi-sector, multi-market, and multi-objective environment, without forgetting quality, comfort, health and acceptation. The WeForming Framework will deploy an umbrella framework covering all aspects around the establishment and adoption of iGEBs in cities, which consists of (i) a Building Operational Pillar encompassing all assets of iGEBs, including the energy management systems and the different platforms, aiming towards the building operational optimization, the actors and the actual flexibility resources, generation and storage components; (ii) a novel Interoperability Assurance Pillar which leverages on, adapts, evolves, and specifically validates leading-edge interoperable architectures; (iii) a Business Pillar including all necessary processes to bring the proposed solutions to the market, through the design and validation of sustainable and competitive business models, ensuring the economic viability of the investments needed for the establishment of smart cities featuring new and refurbished iGEBs; (iv) a Smart-city enabling Pillar integrating iGEBs as modular units addressing all different non-technical barriers and limitations for the widespread deployment of the proposed solutions that will create a stock of active buildings acting as active utility nodes within cities.

Keywords: intelligent buildings,building to grid integration,data space connector,sgam architectures,power hub
Molecular Editing Towards Non-Classical Carbocations Enables Unprecedented Stereocontrolled SN1 Reactions (StereoNOne)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Israel
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 263854.63
EU funding (EUR): 184698.24
Participants: 2
Project status: CLOSED

SN1 reactions represent a possibility for stereocontrolled substitutions on tertiary and quaternary carbons, however the realization of this transformations remains an open issue. To tackle the challenge of realizing general protocols including a stereochemical information in SN1 reactions, an intriguing viewpoint involve the exploitation of non-classical carbocation (NCCs). NCCs intrinsically have a stereochemically robust nature since one face is shielded by their carbon skeleton, allowing an easier control of stereochemistry. In the last years, Marek’s group have been interested in the chemistry of non-classical carbocations resulting from the dissociation of cyclopropyl carbinols. The group has faced and rationalized this challenge, and stereospecific SN1 at quaternary stereocenters of cyclopropanes has emerged as a powerful tool for the construction of stereodefined acyclic structures. A complete inversion of configuration was observed in the presence of different nucleophiles, filling a methodological gap in organic chemistry. To overcome the current state of the art, the establishment of a general approach that would control stereochemistry for SN1-type reactions extending the generality of the already impressive results obtained by the host group is meticulously planned. The aim of this proposal is to broaden the chemistry of stereocontrolled SN1 using 4-membered rings for the creation of acyclic stereo- and enantiodefined systems. Furthermore, in the following sections a detailed description about the impact that this action will have on the growth of the hosting group, the synthetic chemistry community and my career is highlighted.

Keywords: molecular editing,skeletal rearrangements,stereoselective transformations,sn1 reactions