Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Anthropocene Frontiers: Colonial Climate Science in Siberia and Central Asia (AnthroFront)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

The AnthroFront project analyzes the relationship between climate science and colonial violence from the perspective of the Russian Empire’s Siberian and Central Asian frontiers in the earlier nineteenth century. Scholars have shown how climate science developed on the scale of Europe’s late overseas and land empires in the late nineteenth and twentieth centuries. Far less is known about the knowledge produced by earlier processes of conquest and the expropriation of Indigenous land. This project studies a cohort of Baltic-German scientists dispatched to Russian frontiers to understand how borderland encounters generated knowledge about climate change. The first comprehensive study of colonial climate sciences in the Russian Empire, this project develops a new framework for understanding interdisciplinary and intercultural exchanges of climate knowledge. The project gives historical context to contemporary policy debates and provides a pedagogical model for teaching climate history in public schools. Research integrates German and Estonian archives with digitized sources and focuses on three core themes: (1) the role of instructions in organizing colonial travel, (2) the dynamics of encounter between settler, Indigenous, and expeditionary groups, and (3) the circulation of knowledge from central Europe to Central Asia and back. The project will be carried out over twenty-four months in the Department of History of Science and Ideas at Uppsala University under the supervision of Dr. Linda Andersson Burnett, Senior Researcher in the history of colonial travel and indigeneity. The fellowship is also enriched by collaboration with Dr. Jennifer Keating at University College Dublin, a leading environmental historian of Imperial Russia. While advancing the MSCA Green Charter through public outreach, the project will produce two research articles and a special journal issue based on an interdisciplinary conference, laying the groundwork for a subsequent monograph.

Keywords: climate science environmental history german science imperial russia nineteenth century settler colonialism
SMART PUBLIC TRANSPORT INITIATIVES FOR CLIMATE-NEUTRAL CITIES IN EUROPE (SPINE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Innovation actions
Countries involved: Greece,Belgium,Italy,Estonia,Spain,Slovakia,Portugal,Croatia,Poland,Sweden,France,Cyprus,Germany,Romania,Latvia
Call: Unleashing the innovation potential of public transport as backbone of urban mobility (HORIZON-MISS-2021-CIT-02, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 17020515.92
EU funding (EUR): 14600074.0
Participants: 43
Project status: SIGNED

SPINE’s vision is to accelerate the progress towards climate neutrality by reinforcing PT systems through their smart integration with new mobility services, sharing schemes, active transport modes, and micromomibilty. SPINE adopts an equity centred design thinking approach, leading the transition to a more efficient, sustainable, resilient, and inclusive PT system. A network of collaborative LLs is developed to foster transferability, while an intersectional view of the transport system users is applied. Four Lead City LLs in Antwerp, Bologna, Tallin and Las Palmas will be established, and a series of co-creation activities will take place where multiple stakeholders will be actively engaged in the development and demonstration of efficient, replicable, and socially acceptable innovative mobility solutions, advancing existing assets. The SPINE approach involves the creation of (a) innovative simulation and Digital Twining (DT) tools, along with open data and behavioural models, that will allow the building of scenarios combining different mobility interventions (push and pull measures along with supporting policies) and the implementation of the most promising ones; (b) data-driven impact assessment models that will foster the twinning, transferability and adaptation of the successful solutions of the four LLs in seven Twining Cities - Barreiro, Valladolid, Zilina, Sibenik, Hrakleion, Gdynia and Rouen-. SPIRE sets a high ambitious plan for the co-design and implementation of 55 smart greens inclusive mobility solutions. The SPINE consortium brings together a multidisciplinary team of 39 partners from 16 countries. The unique mix of experienced transport engineers, Public transport Operators, computer scientists, data analysts, transport modelers, social scientists, urban planners, policy analysts, software providers, within our consortium assures the comprehensive approach to the challenges, scope, expected impact and the successful delivery of the project.
Molecular and neurogenic evolution of the thalamus (EvoThalamus)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Developmental programs are the playground for evolution. It is during development when most variation occurs. Therefore, developmental variations are the raw material for natural selection sculpting new adaptations. To unravel the evolutionary history of the thalamus, a paradigmatic example within the brain, I propose to compare the development of the thalamus at various levels and in various species of amniotes. At the level of neurogenesis, EvoThalamus proposes to describe the neurogenic formation of the thalamus: linking thalamic nuclei neurogenic time with their location and function. At molecular level, I will describe the transcriptional profiles of thalamic neurons during their differentiation and maturation in the circuit, understanding how transcriptomes diverge on the species along with circuit maturation. At functional level, I will study the broad connectivity routes of the thalamus with the rest of the brain. I propose, in a pioneering way, to integrate multilevel information, to compare all the data of development, transcriptomics and axonal connectivity in a model that links the molecular variations and the developmental program with the appearance of new nuclei and thalamic connections. I will work with chick and gecko embryos, and we will compare the data with those already published in mice. I will look for developmental variations, novelties of the neurogenic program that are not present in the development of the reptilian thalamus. I will find the changes in development that led to the greater complexity of the thalamus of birds and mammals. These evolutionary trends will be a reflection of the multitude of evolutionary changes that occurred in other brain regions. EvoThalamus will equip me with fresh insights into neurobiology, and brain development and evolution. This project will be instrumental for my career and will consolidate me as an independent female researcher in neuroscience.

Keywords: neurogenesis cell types single cell rna sequencing brain connectivity vertebrate development
Decoding leukemia-immune cell dynamics by organism-wide cellular interaction mapping (InteractOmics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1499596.0
EU funding (EUR): 1499596.0
Participants: 1
Project status: SIGNED

Cellular interactions are of fundamental importance in life, orchestrating organismal development, tissue homeostasis and immunity. In the immune system, cell-cell interactions act as central hubs for information processing and decision making that collectively determine the outcome of complex immune responses. In leukemias, a cancer originating from immature immune cells, a multilayered network of cellular interactions between immune and leukemic cells underlies effective immune control of the cancer, immune evasion and response to immunotherapies. However, technical limitations in studying cell-cell interactions restrict our understanding into these highly complex and dynamic processes. In order to overcome this limitation, I propose to develop a novel ‘interact-omics’ approach, capable of characterizing millions of cellular interactions across complex organ systems, entire organisms and patient cohorts. Applying the ‘interact-omics’ approach to sophisticated leukemia mouse models will enable us to dissect the dynamic cellular interaction networks between antigen-specific T cells, bystander immune cells and leukemic cells that drive anti-leukemia immunity and immune evasion. In combination with the in vivo perturbation of cellular interactions, this will allow us to systematically decode the cellular logic of how the complex leukemia-immune interplay determines the disease course. Additionally, by making use of leukemia patient cohorts which are either responsive or non-responsive to immunotherapy treatment, we will unravel previously unknown therapy resistance mechanisms and predict therapy response. Together, our approach will set the basis for a comprehensive understanding of the leukemia-immune cell crosstalk underlying immune control, immune escape and therapy response, and may serve as a blueprint to fundamentally expand our insights into other biological processes driven by cellular interactions.

Keywords: single cell technologies,leukemia,cellular interactions
A Unifying Principle Underlying Social Bonding: Towards a Psycho-Biological Theory (BIOBOND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1499875.0
EU funding (EUR): 1499875.0
Participants: 1
Project status: SIGNED

Imagine a first date, where partners feel an immediate bond, versus an awkward date, where partners feel disconnected. BioBond asks whether there is a biological mechanism that is set to differentially favour bonding in the first date over the second. Despite substantial research on social bonding, we are still without an understanding of what drives social animals to bond and prefer selected individuals. BioBond aims to provide, for the first time, a novel and empirically-validated biological theory of sociality, tying fundamental physiological processes, like glucose metabolism, arousal or temperature, to social bonding, where physiological efficiency during interactions impacts bonding probability. This is not limited to romantic partners, but rather is suggested as a unifying principle that explains bonding: any social interaction that advances physiological gains reinforces bonding. Empirically validating such a unifying principle would demonstrate how complex behaviour emerges from a simple biological feature. Importantly, since physiological gains are quantitative, they can implement selective bonding, where interactions with higher physiological gains are more strongly reinforced. My approach is interdisciplinary, lying at the intersection of neuroscience, biology and psychology, with four mutually-informative lines of research: (1) Demonstrate how social interactions impact physiology by quantifying glucose metabolism, arousal and temperature during interactions v. alone in two major human bonds- parental and romantic; (2) Map the neurobiological pathway via which interactions impact physiology in real-time social interactions; (3) Demonstrate a causal effect of physiological gains on bonding by altering physiology during interactions; (4) Provide an evolutionary perspective by demonstrating it in an additional social species. BioBond is ground breaking in offering a novel, theory-based, testable biological mechanism for bonding across bonds and species.

Keywords: homeostasis,allostasis,sociality
Dryland agriculture and Land use; past, present and future resilience [AGRI-DRY] (AGRI-DRY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,France,Botswana,United Kingdom,Italy,Denmark,South Africa,United States
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 1915401.6
EU funding (EUR): 1915401.6
Participants: 12
Project status: SIGNED

The interest in traditional agriculture is a worldwide trend: as people reclaim their heritage, they increasingly turn to lessons learned by their ancestors about how to sustainability interact with their environment. The network "Dryland agriculture and Land use; past, present and future resilience [AGRI-DRY]" aims to develop an interdisciplinary approach to traditional crop cultivation through the recognition of the complementary value of cultural heritage and sustainable living. Human cultural development is inextricably linked with the development of agriculture. This bond resulted in the "domestication" of the biological and physical environments around us, and historically shaped and engendered present-day landscapes. Agricultural landscapes are a testimony to humanity's long interaction with the land, often-unique examples of the whole people-nature system. They demonstrate a rich cultural and landscape diversity, sustainable land-use systems and, in some cases, people's daily struggle for survival under extreme climatic and environmental conditions. It is now recognized the key role of traditional knowledge of indigenous people and local communities for ecosystem management and sustainable use of resources in the light of climate change. AGRI-DRY aims to bring about a significant reorientation of European and African doctoral training in traditional agriculture. The change will involve both substance and approach. The substance is the strong focus on rigorous techniques for interdisciplinary research. The approach is the emphasis on both research and applicative work, through the participation of both academic and advocacy and policy-making institutions. AGRI-DRY represents a unique opportunity for European young researchers to form a "critical mass" and enjoy a wide array of training opportunities that will be competitive with the best programmes offered outside Europe.

Keywords: archaeobotany,crop cultivation,traditional ecological knowledge,ethnoecology,resilience,modelling,sustainability,food security,policy
In vitro and In-cell characterization of Quadruplex-duplex hybrids: conformation, folding, and recognition by drug-like ligand molecule (QDHassay)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 2
Project status: CLOSED

Nucleic acids are intrinsically polymorphic. Apart from the Watson-crick duplex, guanine-rich sequences can form G-quadruplex (G4) structures, which have become attractive targets for small molecule ligands. It is now proven that G-quadruplexes can form in cells. Today most biophysical and structural/ligand binding studies are carried out in dilute aqueous solutions and the presence of artificial crowding agents/cosolvents. Still, recent works suggest that the folding of G4s may differ in the cellular milieu context due to the agents' limitations. Thus there is an immense need for in-cell-based structural biology approaches. In the proposal, I aim to address critical milestones leading to the bioactive conformation inside the cell and the development of effective/specific G4 targeting drugs using an essential sub-class of G4 structures as a paradigm, namely quadruplex−duplex hybrids (QDH-hereafter). We will focus on low- and high-resolution spectroscopic approaches and mass spectrometry-based ligand screening assays characterizing ligand-QDH interaction. On the methodological part, we will develop in-cell NMR in "native" conditions (starting from unfolded conformation: denovo folding) and propose a ligand screening assay inside the cellular system. Our project will contribute to unveil fundamental principles of nucleic acid folding. It will also foster collaboration between two European institutes specialized in complementary biophysical and structural approaches to study biomolecular folding. In a nutshell, the Maria Skłodowska Curie fellowship will flourish my scientific excellence and the resilience needed for my original ideas to become a reality and communication and public engagement skills across cultures and disciplines.

Keywords: nmr,in cell nmr,nucleic acids,quadruplex duplex hybrid,dna drug interaction
Novel small molecule attenuator of neuroinflammation in Parkinson’s Disease (NEUROSHIELD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-06-01
End date: 2026-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Parkinson’s disease (PD) affects 8.5 million individuals worldwide according to WHO estimates. PD remains cureless and treatments are based on administration of dopamine precursors or analogues. Neuroinflammation is a central hallmark of PD, however, no molecule is present in the market to tackle neuroinflammation in PD patients. Neuroinflammation contributes to the exacerbation of the disease, as the release of inflammatory signals leads to reduced neuronal fitness driving to neuronal death. NEUROSHIELD will address this gap in PD treatment, to ensure an increased quality of life of PD patients, while exploiting this therapeutic market opportunity. The use of non-steroidal anti-inflammatory drugs (NSAIDs) in PD has been considered non-effective or raised long-term usage complications due to adverse side-effects. NEUROSHIELD will employ a novel small molecule tackling neuroinflammation through a yet unexplored pathway, different mechanism to the classic NSAID COX-2 inhibitors mechanism. We have identified a novel potent first-in-class small molecule that is a strong attenuator of neuroinflammation. NEUROSHIELD aims to explore this new safe, brain-permeable molecule, addressing neuroinflammation in Parkinson’s disease through a novel pathway
Design and Chemical Construction of Quasi-living Phagocytic Synthetic Cells for Artificial Phagocytosis of Bacteria (PhagoSynCell)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1999375.0
EU funding (EUR): 1999375.0
Participants: 1
Project status: SIGNED

The growing occurrence of antimicrobial-resistant infections, compounded with the stalling development and approval of new antibiotic drugs, has created a therapeutic gap, threatening a global health crisis. Resistance emerges when bacteria mutate their molecular targets for antibiotics, evading their action. Is it conceivable to design synthetic cells assembled from abiotic synthetic macromolecules, capable of mimicking the most salient features of phagocytosis —Nature’s most selective, effective, and advanced strategy to eradicate pathogens? The aim of PhagoSynCell is to create Phagocytic Synthetic Cells (PSCs) that selectively recognize, capture, engulf and kill antibiotic-resistant bacteria without generating selection pressure for resistance. Firstly, we will develop the membrane of the PSCs by the simulation-aided synthesis of novel macromolecular amphiphiles (Janus dendrimers and amphiphilic comb polymers) self-assembled into vesicle libraries with functional diversity and phenotype programmability. We will then study novel methods to facilitate engulfment of micro-objects by leveraging principles of mechanical actuation programmed at the molecular level. We will introduce superselectivity to artificial membranes to selectively capture bacteria. Furthermore, we will develop an antimicrobial strategy triggered and activated by engulfment that disrupts the bacterial membrane —an element highly unsusceptible to evolution. Finally, we will demonstrate the efficacy of PSCs against pathogenic antibiotic-resistant strains and show their biosafety in cells, organoids, and advanced tissue models as proof-of-concept for future applications. PhagoSynCell will unveil the underlying principles of Artificial Phagocytosis, delivering synthetic cells able to selectively recognize and kill bacteria. Ultimately, this will provide the steppingstone towards the use of synthetic cells as a quasi-living therapeutic —a field I envision will revolutionize medicine.

Keywords: synthetic cells bottom up synthetic biology superselectivity polymer chemistry advanced antimicrobials