Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Wearable multiplexed biomedical electrodes (WEARPLEX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Norway,Serbia,Sweden,Switzerland,Norway,Finland,Denmark,United Kingdom
Call: Flexible and Wearable Electronics (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-02-28
Duration (months): 38.0
Total project cost (EUR): 3732748.75
EU funding (EUR): 3732748.75
Participants: 12
Project status: CLOSED

WEARPLEX is a multidisciplinary research and innovation action with the overall aim to integrate printed electronics with flexible and wearable textile-based biomedical multi-pad electrodes. It aims to answer the growing need for user-friendly electrodes for pervasive measurement of electrophysiological signals and application of electrical stimulation. It focuses on the development of the printable electronics and manufacturing processes for stretchable textile based multi-pad electrodes with integrated logic circuits that enable a significant increase in the number of electrode pads (channels) and facilitate the creation of new products in the sectors of medical electronics and life-style. The advanced printed electronics integrated in WEARPLEX electrodes will allow the individual pads to be connected in arbitrary configurations to the output leads of the electrode. Therefore, the pads will be flexibly organized into several virtual electrodes of arbitrary position, shape and size that can be connected to any standard multi-channel recording and stimulation system. In addition, software methods will be developed for automatic calibration of these virtual electrodes, to detect stimulation/recording hotspots and adjust the virtual electrodes accordingly. Therefore, the WEARPLEX project will lead to a new generation of smart electrodes that will be able to adapt simultaneously to the user (wearable and stretchable garment), recording/stimulation scenario (movement type and target muscles) and recording/stimulation system (number of channels). This is a paradigm shift in designing the recording and stimulation systems, as the switching electronics is shifted from the custom-made stimulator/recording device to the smart electrode, leading to a universal solution compatible with any system.

Keywords: stretchable multi pad biomedical electrodes
From forest to feed: enable the wood industry to bridge the protein gap (SYLFEED)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Iceland,Iceland,Norway,Belgium,Sweden,Belgium,Norway,France,France,Netherlands
Call: New sources of proteins for animal feed from co-products to address the EU protein gap (H2020-BBI-JTI-2016, 2016)
Start date: 2017-09-01
End date: 2021-08-31
Duration (months): 48.0
Total project cost (EUR): 10018938.87
EU funding (EUR): 8695068.1
Participants: 10
Project status: CLOSED

For decades, Europe has been facing a huge protein deficit (more than 70% is imported). Today, the objective is to initiate ways to sustainably produce proteins in Europe, by creating new cross-sectorial businesses. Partners within the consortium have been developing a bio-refinery concept allowing transformation of woody biomass into high-value Single Cell Protein (SCP) to be used as animal feed. The SYLFEED project consists in upscaling the bio-refinery process to ensure successful demonstration of Arbiom Wood to Food technology consisting in converting lignocellulose into SCP for use in aquaculture. SYLFEED will demonstrate the synergies between forestry industry and protein fish feed market, creating new high value opportunities for the former and an alternative, sustainable, protein source for the latter. Wood residues are abundant and highly sustainable and SCP present an amino-acid profile close to that of the fishes, making them an excellent raw material in fish feed formulation (there is room for more than 50 lignocellulose bio-refineries in Europe, leading to the production of at least 1.4 Mt of proteins and a significant reduction of the protein gap). SYLFEED spans across the full value chain: from biomass stakeholder to fish feed sellers (future buyers of SYLFEED proteins), including biomass-to-SCP technology developer/ experts. SYLFEED’s ambition is threefold: - To respond to strategic needs of protein production in Europe to increase self-sufficiency. - To improve the local economy (forest industry), save jobs in important industrial sectors and create new ones in the bio-economy. - To produce proteins for fish feed in a way that addresses local and global environmental issues (oceans overexploitation and negative effects of plant’s culture – soybean, corn...). To do so, the grand challenge of the SYLFEED demonstration project is to upscale from pilot scale and validate the bio-refinery process that converts lignocellulose into SCP suitable to formulate fish feed.

Keywords: wood,lignocellulose,demonstration plant,biorefinery,pre treatment,hydrolysis,enzyme,2g sugars,single cell protein,fish feed,sustainable,cross sectorial technology,competitive value chain
Social Justice and the Future of Work (SOJUFOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-15
End date: 2022-09-14
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

The aim of this project is to develop and defend a theory of justice for contemporary labour markets in the light of recent and ongoing changes in modern labour markets (in particular the rise of automation, the changing nature of the firm, and the evolution of the gig economy). These trends are receiving sustained analysis by researchers in economics, computer science, and business who tend to evaluate the labour market primarily in terms of economic efficiency. No doubt, this is one of the criteria by which we should assess labour market policies, but it is not the only one. When assessing labour markets, we must also be attentive to the distribution of the benefits and burdens of social cooperation, as well as to which rights individuals possess. I will explore these issues using the tools of normative political philosophy. In the course of this research, I will (i) develop a better understanding of how liberal egalitarian political philosophy can profitably engage with and influence the analysis of public policy, and (ii) develop my capability for engaging with findings in quantitative social science. I will do this under the supervision of Prof. Andrew Williams, who is Editor of Politics, Philosophy & Economics, and Prof. Javier Arregui, who is a specialist in European public policy. The project will be based in the Department of Law at the Universitat Pompeu Fabra (UPF), which hosts an assembly of world-renowned political philosophers working on related themes. The project involves an ambitious dissemination and communication plan. In addition to several seminar presentations and deliverables, I will maintain a project website, organise an international conference, convene a panel at the American Political Science Association Annual Meeting, participate in workshops with Catalunya Europa and at the Bank of England, carry out an interview with the New Economics Foundation, and teach in schools.

Keywords: political philosophy,social justice,the future of work
Antarctic Cyclones: Expression in Sea Ice (ACES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-14
End date: 2022-03-09
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The Amundsen Sea Low (ASL) is an atmospheric low pressure system that sits over the Pacific sector of the Southern Ocean. Variations in the position and strength of the ASL have a strong influence on Antarctic climate change, controlling both Antarctic sea-ice trends and ocean melting of the Antarctic Ice Sheet. However, the classical view of the ASL as a large, smooth region of low pressure is misleading. The ASL is an average of many short-lived atmospheric cyclones, and the effect of the ASL on local climate is the highly non-linear net effect of these cyclones. ACES will investigate the role of the individual cyclones and their net effect on the changing climate of West Antarctica by achieving three main objectives: (1) Characterise the physics of cyclones by tracking them with machine learning algorithms in atmospheric re-analysis data and sea ice drift satellite observations. Elucidate cyclone-sea ice-ocean interactions using a model of individual cyclones. (2) Use the new understanding to improve a circum-Antarctic ice-ocean model, determining the effect of cyclone dynamics on hindcasts of ice shelf basal melting in West Antarctica. (3) Assess climate model representations of cyclone-sea ice-ocean interactions, enabling them to better represent past and future sea ice extent and future ice shelf basal melt rates. ACES will be the first attempt to comprehensively characterise the role of individual cyclones over sea ice. It will generate a solid physical understanding of cyclone-sea ice-ocean interactions, as well as improve past estimates of ice shelf basal melt rates and provide important feedback on the capability of climate models to represent Antarctic sea ice trends and ice shelf basal melt rates.

Keywords: climate modelling
Virtual Power Plant for Interoperable and Smart isLANDS (VPP4ISLANDS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Italy,Spain,Italy,Germany,Spain,Spain,Türkiye,Türkiye,Türkiye,France,France,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Decarbonising energy systems of geographical Islands (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 7223108.75
EU funding (EUR): 6119378.75
Participants: 20
Project status: SIGNED

VPP4Islands aims to facilitate the integration of renewable systems, accelerate the transition towards smart and green energy and help Islands to exploit energy efficiency potential and innovative storage approaches, foster the active participation of citizens and become self-sufficient in energy, while reducing costs, GHG emissions and reliance on heavy fuel oil to generate power, and creating new intelligent business, growth and local skilled jobs. To reach these goals, VPP4Islands project proposes disruptive solutions based on digital twin concept, Virtual energy storage systems (VESS) and Distributed Ledger technology (DLT) to revolutionize the existing VPP and build smart energy communities. Based on aggregation and smart management of distributed energy resources (DERs), VPP4Islands increases the flexibility and profitability of energy systems while providing novel services. VPP4Island will also enhance the Demand Response Capability of consumers by understating their behaviors and promoting self-consumption. In order to validate and evaluate the proposed solutions, two use cases in real-life with diverse assets in two leading islands are planned. The control and optimization of different systems will be extended to consider not only electrical, but also multi-energy vectors. Moreover, the qualified VPP4Islands solutions will be replicated in 3 follower islands, in order to generate and initiate smart sustainable energy plans. Also, VPP4Islands will generate durable social and environmental values for the benefit of consumers/prosumers. Finally, VPP4Islands project consortium is composed of 1 large company, 1 DSO, 7 SMEs, 3 universities, 2 RTOs, 3 islands municipalities, and 2 non-profits organisation.

Keywords: islands,digital twin,machine learning,open platform,virtual energy storage system,distributed ledger technology,cybersecurity,p2p market,business models
Design of multifunctional phosphorous dendritic systems for drug delivery (EUREKA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-04
End date: 2022-02-03
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The aim of the project is to provide the interdisciplinary training to young talented researcher Dr. Evgeny Apartsin, specialist in biomaterials science and nucleic acid therapy, to become highly qualified world class researcher. The Applicant proposes an interdisciplinary approach for the design of multifunctional phosphorous dendritic systems for the delivery of therapeutic nucleic acids in vitro and in vivo. During the project implementation, novel stimuli-sensitive supramolecular constructions based on phosphorous dendrimers and dendrons will be created to be used as carriers for chemodrugs and nucleic acids. The synthetic part of work will be done in the Host organization, which is world leading institution in the dendrimer science and applications. The physics-chemical and biological parts will be done in collaboration with the Partner organization together with recognized specialists in biophysics, molecular and cell biology. At the last stage of the project, the synthesis of best candidate therapeutic constructions will be transferred to the industry. The Applicant will receive numerous scientific trainings from the experts in macromolecules and medicinal chemistry, molecular biology and industrial technology as well as additional trainings on project management and funding, public dissemination of results, presenting and teaching. The trainings and the implementation of this project (knowledge, skills, papers, patents, etc.) will help the Applicant to be efficiently integrated into the European and international science at highest level.

Keywords: dendrimers,dendrons,nucleic acid therapeutics,targeted drug delivery,chemodrugs,micelles,liposomes,encapsulation
Membrane trafficking as a link between cell polarity and intestinal absorptive function: from C. elegans to mammalian miniguts (GUTPOLAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-06
End date: 2021-05-05
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The GUTPOLAR project aims at sustainably reintegrating an Experience Researcher (ER) who will acquire the necessary knowledge and skills to reinforce European research on rare malabsorption diseases. Food absorption relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border (BB) at their luminal (apical) pole. Some rare genetic malabsorption disorders, characterized by mispolarized PAR polarity modules and BB structural proteins, are caused by mutations in genes coding for membrane traffic factors (i.e. Myo5B in microvillus inclusion disease/MVID). Despite this functional link, little is known about the genetic, physical and functional interactions between membrane traffic, polarity and BB components in vivo and how they control intestinal absorption. The ER uncovered a new role of the V0 sector of the V-ATPase, a complex that controls membrane traffic through organelle acidification, in both polarity and BB components apical polarity maintenance in C. elegans intestine. Most interestingly, V0-ATPase depletion in C. elegans recapitulates the cellular phenotypes observed in patients with MVID, making this complex a very exciting candidate which mechanism, genetic partners and mammalian function need to be characterized. To this end, the ER will first use genetics and super-resolution imaging to study the trafficking routes and the molecular mechanisms controlled by the V0-ATPase in vivo in C. elegans intestine. Then, he will implement mouse intestinal organoids (thanks to a secondment in H. Farin’s lab, Frankfurt, Germany) and use this model to study the conservation of these mechanisms in mammals. Overall, the GUTPOLAR action will allow to describe evolutionary conserved pathways of polarity maintenance and identify some of the mechanisms leading to absorption disorders that may provide the medical community with new therapeutic targets.

Keywords: membrane trafficking,polarized sorting,epithelial polarity,gut development,absorption,rare genetic absorption disorders
Unravelling the molecular and cellular mechanism of metastasis (MS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland,Switzerland,Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-29
End date: 2022-04-03
Duration (months): 22.0
Total project cost (EUR): 178320.72
EU funding (EUR): 178320.0
Participants: 3
Project status: CLOSED

Metastasis is the primary cause of cancer deaths. For most cancers, the identification and the mechanisms by which the metastatic initiating cells (MICs) successfully establish a secondary tumour at a distant site from their primary tumour remains elusive (1). New animal models are needed to better understand the clonal dynamic and molecular mechanisms guiding different steps of the metastatic cascades in vivo, given the tremendous heterogeneity of tumours (2-7) and the limited capacity to trace multiple genetic clones in parallel with the traditional reporter mice (8). This will aid the design of new methods for early diagnosis and the monitoring of patients with metastasis, as well as the development of new strategies that target or prevent metastasis. In this project, I will use clonal lineage tracing with Poly-Lox reporter that enables tracing of over 200’000 clones (9) and confetti reporter (10) combined with single cell transcriptional profiling in order to define the cellular and molecular mechanisms that regulate the metastatic cascade in vivo in two different mouse models of squamous cell carcinoma and breast tumour. With the immunostaining, FACS and single cell sequencing analyses I will study the role of various fibroblast sub-populations in affecting the extravasion and establishment of tumour cells at the site of metastasis.

Keywords: metastasis,cancer,dna barcoding
An integrated approach to dissect determinants, risk factors and pathways of ageing of the immune system. (ImmunoAgeing)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Italy,United Kingdom,United Kingdom
Call: Understanding health, ageing and disease: determinants, risk factors and pathways (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 5850000.0
EU funding (EUR): 5850000.0
Participants: 5
Project status: CLOSED

Age-related changes in the immune system, also known as ‘immunosenescence’, have a huge detrimental impact on the health of our ageing populations. However, the extent and mechanisms of the changes, and thus possible routes to prevention or alleviation, are largely unknown. We propose to analyse immunosenescence with unprecedented resolution by determining in large cohorts of volunteers the changes with age in circulating levels of ~140 subtypes of immune system cells and ~25 immune molecules, including cytokines and antibodies. We will also quantify age-related immune dysfunction, and notably autoreactivity, by determining the specificity and level of key circulating autoantibodies and their correlation with contractions in the B & T cell repertoire in our large general population ageing cohorts. Underlying genetic and major environmental factors -- including life style choices like smoking, diet, alcohol intake and, physical activity as well as transmissible viral infections -- will be systematically analysed. The analyses will build on our studies on levels of immune system cell subsets and inflammatory biomarkers in genetically well characterized population cohorts, and will be followed up by examining sorted circulating cells for ageing-related shifts in transcriptional profiles and function. For these targetted experiments, our focus,will be on cell types that show the greatest changes with age and/or are most critical for immune responsiveness; and from volunteers selected based on their genetic and epidemiological exposure profiles. Studies will be facilitated by complementary expertise of the participating centres, capitalising on unique bioresources. Overall, the advances in knowledge should better elucidate pathways of immunosenescence, reveal new biomarkers for early diagnosis of immune dysfunction, and point to target cells and molecules that can be supplemented or activated for eventual prevention or alleviation of ageing-related immune dysfunction.

Keywords: immunosenescence,bio resources,cohorts,facs,blood virome,autoimmunity,inflammation,t cell,b cell,monocyte,cytokine,autophagy,environmental,genetic,risk factor,eqtl,rnaseq