Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Effective Methods in Tame Geometry and Applications in Arithmetic and Dynamics (EffectiveTG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 1155027.0
EU funding (EUR): 1155027.0
Participants: 1
Project status: SIGNED

Tame geometry studies structures in which every definable set has a finite geometric complexity. The study of tame geometry spans several interrelated mathematical fields, including semialgebraic, subanalytic, and o-minimal geometry. The past decade has seen the emergence of a spectacular link between tame geometry and arithmetic following the discovery of the fundamental Pila-Wilkie counting theorem and its applications in unlikely diophantine intersections. The P-W theorem itself relies crucially on the Yomdin-Gromov theorem, a classical result of tame geometry with fundamental applications in smooth dynamics. It is natural to ask whether the complexity of a tame set can be estimated effectively in terms of the defining formulas. While a large body of work is devoted to answering such questions in the semialgebraic case, surprisingly little is known concerning more general tame structures - specifically those needed in recent applications to arithmetic. The nature of the link between tame geometry and arithmetic is such that any progress toward effectivizing the theory of tame structures will likely lead to effective results in the domain of unlikely intersections. Similarly, a more effective version of the Yomdin-Gromov theorem is known to imply important consequences in smooth dynamics. The proposed research will approach effectivity in tame geometry from a fundamentally new direction, bringing to bear methods from the theory of differential equations which have until recently never been used in this context. Toward this end, our key goals will be to gain insight into the differential algebraic and complex analytic structure of tame sets; and to apply this insight in combination with results from the theory of differential equations to effectivize key results in tame geometry and its applications to arithmetic and dynamics. I believe that my preliminary work in this direction amply demonstrates the feasibility and potential of this approach.

Keywords: model theory o minimality,diophantine geometry unlikely intersections,pfaffian functions,ordinary differential equations complex domain,subanalytic geometry
Optoelectronic detection of single spin in silicon (ODESI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 152430.0
Participants: 1
Project status: CLOSED

Quantum physics, when applied to computing, is projected to lead to revolutionary enhancements in computational speed and power. However, to construct such a "quantum” computer, its building blocks, called qubits, have to be resistant to environmental disturbance; they need to hold the information encoded within them for long periods. One of the most promising ways to create such qubits consists in exploiting the spin degree of freedom of natural atoms implanted in silicon. This project proposes to investigate the coherent manipulation of a single door electron spin coupled to a charge detector. For this purpose, we will develop a new technique to determine the spin state of a single donor, relying on a spin-to-charge conversion induced by bound-exciton optical transitions. This method shows several advantages: it can work up to 4K, and at low magnetic field. It has been successfully implemented on assembly but never at the single donor level. The final experiment of this project will comprise two steps: i) the manipulation of the spin information using microwave excitations in order to create superposition of states ii) and the reading of the spin information using an optoelectronic detection scheme, which is at the centre of this project.

Keywords: silicon,nanoelectronic,bound exciton,optoelectronic,magnetic resonance,charge detection
Modular Open Platform for Static Analysis (MOPSA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2021-11-30
Duration (months): 66.0
Total project cost (EUR): 1773750.0
EU funding (EUR): 1773750.0
Participants: 2
Project status: CLOSED

The Mopsa project aims at creating methods and tools to make computer software more reliable. Programming errors are pervasive with results ranging from user frustration to huge economical or human losses. Traditional test-based methods are insufficient to eliminate all errors. The project will develop static analyses able to detect at compile-time whole classes of program defects, leveraging the theory of abstract interpretation to design analyses that are approximate (to scale up to large programs) and sound (no defect is missed). Static analysis has enjoyed recent successes: Astrée, an industrial analyzer I have coauthored, was able to prove the absence of run-time error in Airbus software. But such results are limited to the specific, well-controlled context of critical embedded systems. I wish to bring static analysis to the next level: target larger, more complex and heterogeneous software, and make it usable by engineers to improve general-purpose software. We focus on analyzing open-source software which are readily available, complex, widespread, and important from an economical standpoint (they are used in many infrastructures and companies) but also societal and educational ones (promoting the development of verified software for and by citizens). A major target we consider is the set of technologies at the core on Internet on which static analysis could be applied to ensure a safer Internet. The scientific challenges we must overcome include designing scalable analyses producing relevant information, supporting novel popular languages (such as Python), analyzing properties more adapted to the continuous development of software common in open-source. At the core of the project is the construction of an open-source static analysis platform. It will serve not only to implement and evaluate the results of the project, but also create a momentum encouraging the research in static analysis and hasten its adoption in open-source development communities.

Keywords: program verification,formal methods,static analysis,abstract interpretation
The Dynamics of Solidarity on Madagascar: An Ethnography of Political Conflicts and Appeasement Strategies in the Context of a Pronounced Consens Norm (DySoMa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Madagascar
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2020-01-03
Duration (months): 36.0
Total project cost (EUR): 236210.4
EU funding (EUR): 236210.4
Participants: 2
Project status: CLOSED

The aim of this anthropological research project is to improve understanding of the peace-making processes operating in the ongoing Malagasy political crisis. A dispute in 2009 over the Malagasy presidency, the most powerful political position on the island, marked the beginning of a particularly difficult period. At first tensions were limited to the national political level, but the situation rapidly degenerated into a more general social crisis as international support was suspended, the economy plummeted down and the population of about 22 million had to cope with great insecurity. In this period of acute risk to social order a number of unusual conflict resolution strategies were adopted independently. Alongside the official, internationally brokered negotiations, there were a number of distinctive, local mechanisms which had a clear, positive impact on the situation. The innovative institutional embodiment of a local concept of solidarity rooted in traditional ancestor worship (fihavanana) and popular justice movements led by charismatic personalities were amongst the most important in paving the way for conflict resolution and a new beginning for Madagascar. The rarity of such successful conflict resolution in post-colonial contexts arouses curiosity and demands close evaluation. An attractive scientific challenge is triggered, offering a unique opportunity to devise an ethnography of de-escalation and peace which will stand in contrast to the conventional focus on war and disorder. Anthropological fieldwork in Antananarivo (the Madagascan capital) and the Western Melaky region as well as historical research will furnish qualitative evidence for an insightful interpretation of the unique dynamics of solidarity observed. The project will contribute to a better understanding of the recent Malagasy crisis but will also provide an important case study of theoretical and practical relevance to political anthropology and international peace-building initiatives.

Keywords: political conflicts and conflict solution,normativity of solidarity,madagascar,reconciliation,postcolonialism,peaceful societies,fihavanana,committee of malagasy reconciliation
Self and others in the sensorimotor system: a computational neuroanatomy of sensory attenuation (TICKLE ME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Why can’t you tickle yourself? Previous behavioural and neuroimaging evidence suggests that when we move one hand to touch the other, the resulting tactile sensation is perceived as less intense compared to identical touches of external origin. This sensory attenuation (SA) phenomenon is hypothesized to arise because our brains use internal information about the motor command (efference copy) to predict the tactile consequences of the movement and attenuate the tactile feedback based on these predictions. However, little is known about how the brain produces SA. ‘TICKLE ME’ combines, for the first time, computational motor control theory, force perception behavioural experiments, and state-of-the-art neuroimaging methods to address how the human brain distinguishes between self-generated and externally-generated touch. The project aims to: - clarify the principal importance of voluntary motor commands, efference copy, and perceived physical contact of body parts in a series of behavioural experiments - identify the neuroanatomical network responsible for generating SA by using state-of-the-art functional magnetic resonance imaging - investigate how the brain learns to predict the sensory consequences of our actions by using error-driven learning mechanisms - develop a novel neurocomputational model of SA The project will result in a synergy between the applicant’s highly interdisciplinary profile and the high quality of the host institution. The applicant has experience in different scientific areas such as experimental cognitive psychology, psychophysics, virtual reality, computational modeling and programming as well as a background in electrical engineering that makes her uniquely suited to carry out this project. Additionally, the Karolinska Institutet, the Department of Neuroscience, and in particular Prof. Henrik Ehrsson will provide valuable theoretical knowledge in sensorimotor control as well as technical expertise in neuroimaging in support of the project.

Keywords: tickle,force matching,sensory attenuation,sensorimotor control,tactile predictions,forward models,cerebellum,somatosensory cortex,parietal cortex,functional magnetic resonance imaging
Viral Vaccine Vectors in Personalized Medicine (VIVAVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-02-01
End date: 2018-12-31
Duration (months): 23.0
Total project cost (EUR): 149858.0
EU funding (EUR): 149858.0
Participants: 1
Project status: CLOSED

Melanoma and lymphoma are tumors that strike millions of people worldwide and require aggressive and expensive therapies. Numerous therapies are already being used or in the pipeline, yet all of them focus on the rapid elimination of the active neoplastic process. They do not provide options for long-term surveillance and deterrence of minimal residual disease, that is, of cancer relapse arising from the few tumor cells that survive the aggressive bout of therapy. Therefore, even patients considered cancer-free upon successful therapy are monitored over decades for potential relapses and condemned to a life of uncertainty. I propose to develop a novel class of versatile tumor vaccines for long-term surveillance of tumors based on a modified virus vector. Our modified viral vector combines an exceedingly safe profile with robust and long-lasting immunity. Several developers have focused on human virus vaccine vectors that grow poorly in tissue culture, and as human pathogens, present iatrogenic concerns. Our modified viral vector system grows faster in animal cells than human counterparts, but cannot replicate in human cells. Therefore, our vector system is generally considered innocuous for humans. The replication in human cells is aborted at the early stage of infection, but immediate-early genes are expressed at robust levels, and thus may stimulate immune responses. Our modified viral vector system establishes latency and is maintained for life in the nuclei of infected cells, where they release low levels of antigen for the life of the host. Thus, it provides a depot of antigen that is slowly released over time and promotes the uniquely strong and sustained immunity. Our approach is unique in its design to provide long-term immune surveillance of tumor cells, and thus in blocking relapses. Hence, we propose to develop a unique product that fills an important clinical need.

Keywords: vaccine vector,cytomegalovirus,tumor vaccine,minimal residual disease,melanoma
Advanced Energy STorage and Regeneration System for Enhanced Energy Management (ESTEEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,United Kingdom
Call: Advanced Energy Storage and Regeneration System for Enhanced Electrical Energy Management (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-07-01
End date: 2021-12-31
Duration (months): 54.0
Total project cost (EUR): 826432.5
EU funding (EUR): 826432.0
Participants: 3
Project status: CLOSED

ESTEEM Consortium will bring together their world-leading expertise in aircraft Electrical Power Systems (EPS), Power Electronics (PE), advanced control systems, modelling and simulation for aerospace applications, Energy Storage System (ESS) and smart and Enhanced Electrical Energy Management (E2-EM) strategies to design, develop and manufacture an innovative Energy Storage and Regenerative System ESRS with embedded supercapacitors Energy Storage Device (ESD) for smart energy management of a regenerative Electro-Mechanical Actuator (EMA) emulator. The developed system components; ESD and EMA emulator will be connected together by a Secondary Electrical Distribution Centre (SEPDC) to constitute the ESRS. Then, the ESRS will be interfaced with the “Iron Bird” to demonstrate the concept of advanced Electrical Power Distribution System (EPDS) with E2-EM functionalities. The aim is to demonstrate the E2-EM functionalities for future aircraft EPDS and contributing towards the achievement of more efficient, greener aviation. The developed demonstrator will be efficient, reliable, compact and lighter and smarter. The key system component will be a newly designed DC/DC converter for interfacing the supercapacitors ESD with the SEPDC, which will be under control of supervisor to implement E2-EM functionalities and energy-management algorithm. Intelligent and adaptive converter control algorithm will be developed to provide high dynamic performance essential for fast control of peak power under situations of gird parameters variation. The converter control will consider the implementation of state of health and monitoring algorithms for the supercapacitors ESD. The ESTEEM innovations will reach the market through integration within the Regional IADP in Clean Sky 2. The project partners will collaborate with the Topic Manager on a regular basis to ensure that the innovative ESRS demonstrator technology can be seamlessly integrated firstly into the “iron-bird” for ground-based

Keywords: energy recovery,energy management,aircraft electrical power
PREvention of MOther-to-child Transmission of HIV and Syphilis using an Electrochemical Readout based on DNA Switches (PREMOTHER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-07
End date: 2021-01-06
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Mother-to-child transmission of HIV and Syphilis causes approximately 305,000 fetal and neonatal deaths every year and leaves 215,000 infants at increased risk of dying from prematurity, low-birth-weight or congenital disease. An accurate diagnosis of diagnostic-antibodies and a simple treatment during the first weeks of pregnancy could stop all those deaths. Here, I propose the development of a new technique to be used to measure antibodies directly in whole blood. These will combine the multiplexed (i.e., multiple tests in parallel on one sample), quantitative performance of laboratory-based tests with the portability and low-cost of point-of-care tests. As the first step, I will design, optimize and test nanometer-scale, DNA-based “switches” that undergo a dramatic change in conformation (closed/open) upon recognizing its target antibody. I will use this conformational change to generate a large, easily measurable electronic (electrochemical) signal, which I will then employ in and validate as laboratory-scale, single-test devices using both purified antibodies and authentic human samples. I will then integrate the set of sensors exhibiting good clinical performances into a single, paper-based microfluidic sample handing device (similar to the home pregnancy test) to generate a low-cost platform capable of measuring multiple diagnostic antibodies in a single finger-prick blood sample. The final and main goal in the DNA-SPADE project is the development of a working prototype diagnostic device, which I will design accordingly to suggestions/inputs from a variety of possible final users (such as nurses and doctors).

Keywords: diagnostic antibody detection,point of care sensors,mother to child transmission,paper based device
Development of novel optogenetic approaches for improving vision in macular degeneration (RODRESET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-03-31
Duration (months): 54.0
Total project cost (EUR): 1991508.0
EU funding (EUR): 1739984.91
Participants: 2
Project status: SIGNED

In industrialized countries, age-related macular degeneration (AMD) is the leading cause of untreatable blindness. In addition to age-related disease, there are also inherited forms of macular degeneration, such as juvenile-onset Stargardt disease. These conditions, for which there are currently no effective treatments, involve the loss of photoreceptors in the central retina, where a high cone photoreceptor density is responsible for effecting high resolution vision. We recently discovered that cones can modulate the sensitivity of surrounding rod photoreceptors to enable them to be more effective in daylight conditions. In retinal disorders involving degeneration of the macular cones, this lateral interaction is impaired, leading to saturation of the rods’ dynamic range and impaired daylight vision. We have also discovered that direct modulation the neurons underlying this lateral interaction, the horizontal cells, improves quality of vision in mice lacking functional cones. Together, our results identify a specific circuitry underlying rod-mediated vision as a potential therapeutic target following macular degeneration. Here, we aim to exploit these new findings to re-establish the rods’ ability to function in daylight using two distinct approaches. Firstly, we will use direct modification of the rods to permanently shift their light sensitivity into the daylight range. A small area of modified rods that are effective in daylight, likely with a higher temporal resolution, would improve extra-foveal fixation and vision. Secondly, we intend to establish a system that confers light sensitivity onto horizontal cells, to replace light-mediated input from cones. This will restore the natural horizontal cell-derived modulation of light sensitivity to rods, allowing them to function in daylight. Thus, by utilizing our knowledge of specific aspects of retinal circuitry, we aim to develop novel therapies for improving vision in patients with advanced macular degeneration.

Keywords: vision,macular degeneration,gene therapy,optogenetics