Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of an in vitro diagnostic test using novel biomarkers for screening, diagnosis and prognosis of renal cell carcinoma (BIOREK)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2100000.0
EU funding (EUR): 2100000.0
Participants: 1
Project status: SIGNED

BIOREK, founded in 2019 in Milan, Italy, is a biotechnology startup aiming to transform renal cancer screening, diagnosis, and prognosis. The company is developing an advanced in vitro diagnostic (IVD) kit based on novel patented biomarkers and a digital analysis platform. This technology enhances renal cell carcinoma (RCC) screening by (i) detecting kidney masses for early intervention and treatment, (ii) distinguishing between benign and malignant masses to guide treatment and avoid unnecessary procedures, and (iii) assessing cancer aggressiveness and metastasis risk, which helps in (a) monitoring patients under surveillance protocols, reducing aggressive treatments for older or frail individuals with indolent RCC, (b) selecting patients for adjuvant therapies, and (c) prioritizing those with aggressive cancers for surgery. BIOREK’s solution offers multiple benefits: (i) avoiding surgeries for benign renal masses, (ii) effectively monitoring patients for surveillance, reducing aggressive treatments in older/frail patients, (iii) selecting patients for adjuvant therapies, (iv) prioritizing aggressive cancer cases for surgery, and (v) preventing delayed diagnosis. This test aims to reduce both RCC-related and non-RCC-related deaths. By optimizing treatment and managing RCC patients efficiently, healthcare systems will see lower costs and better resource use. As a startup, BIOREK is at the pre-revenue stage. It has raised €1.7M from public and private sources to develop its technology to TRL 5-6 and launch a large clinical study. The IVD kit targets a $1.5B market, with revenue projections reaching €168M by year 5 of commercialisation.

Keywords: renal cancer screening,biomarkers,in vitro diagnostic kit,renal cell carcinoma,early intervention,benign vs malignant distinction,cancer aggressiveness,patient monitoring
Attracting International Experienced Researchers in any Research Field to the Basque Country (SmartBRAIN3)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-01-01
End date: 2029-06-30
Duration (months): 66.0
Total project cost (EUR): 4298400.0
EU funding (EUR): 4298400.0
Participants: 1
Project status: SIGNED

The economic crisis and the lack of resources devoted to research and development (R&D) in Spain is a pressing issue, affecting the Basque region too, and it is aggravated by the European crisis provoked by the COVID-19 pandemic and the Ukraine invasion. The R&D expenditure (% of GDP) in Spain has been reduced in the last decade. Currently, it is half of the European Union average, which is critical. The stabilization of long-term research lines led by experienced researchers, as proposed by SmartBRAIN3, is an unmet challenge that Ikerbasque (beneficiary) proposes to address with the present programme. SmartBRAIN3 aims to offer 30 research contracts for experienced researchers within 2 calls, offering 15 positions in each call. The current programme offers permanent contracts as “Ikerbasque Research Professors” (tenure track positions) to all researchers to be recruited, although each fellowship will last 36 months within the SmartBRAIN3 programme. The impact of such a workforce for the Basque region is welcomed as internal assessments by the Basque research institutions show the lack of experienced researchers in the region. SmartBRAIN3 offers an outstanding research, innovation training and career consolidation programme, with specific focus on the triple-I dimension (international, intersectoral and interdisciplinary), as well as providing an impactful, innovative and inclusive research environment. The 24 implementing partners recruiting and hosting the fellows are leading international institutions within their respective fields. SmartBRAIN3 includes mandatory international secondments, which enhance the researchers’ networks and let them explore intersectoral career paths as well, in support of their career progress. SmartBRAIN3 ultimate impact is to contribute to the challenges and priorities set out in the RIS3-Smart Specialization Strategy of the Basque Country, the United Nations Sustainable Development Goals and the Horizon Europe.

Keywords: experienced researchers,excellence,mobility,training,international and intersectoral secondment,transfer of knowledge,interdisciplinarity,tenure track positions,permanent contract
Universal Platform Components for Safe Fair Interoperable Data Exchange, Monetisation and Trading (UPCAST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Italy,France,Serbia,Greece,United Kingdom,Ireland,Belgium,Norway,Spain,Finland,Austria
Call: Technologies and solutions for data trading, monetizing, exchange and interoperability (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2022-DATA-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 10655452.71
EU funding (EUR): 8587126.25
Participants: 19
Project status: SIGNED

UPCAST provides a set of universal, trustworthy, transparent and user-friendly data market plugins for the automation of data sharing and processing agreements between businesses, public administrations and citizens. Our plugins will enable actors in the common European data spaces to design and deploy data exchange and trading operations guaranteeing (i) automatic negotiation of agreement terms, (ii) dynamic fair pricing, (ii) improved data-asset discovery, (iii) privacy, commercial and administrative confidentiality requirements, (iv) low environmental footprint, as well as ensuring compliance with (v) relevant legislation and (vi) ethical and responsibility guidelines. UPCAST will support the deployment of Common European data spaces by consolidating mature research in the areas of data management, privacy, monetisation, exchange and automated negotiation, considering efficiency for the environment as well as compliance with EU and national initiatives, AI regulations and ethical procedures. Four real-world pilots across Europe will operationalise a set of working platform plugins for data sharing, monetisation and trading, deployable across a variety of different data marketplaces and platforms, ensuring digital autonomy of data providers, brokers, users and data subjects, and enabling interoperability within European data spaces. UPCAST aims at engaging SMEs, administrations and citizens by providing a transferability framework, best practices and training to endow users in order to deploy the new technologies and maximise impact of the project.

Keywords: data,data exchange,monetisation,trading,platform,data sharing,framework,data spaces
Foreign Real Estate Investment, Housing Affordability, and Regulations: A Comparative Political Economy Analysis of 50 Countries (FREIHARC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

The rapid influx of global capital into residential real estate has significantly reshaped housing markets, particularly in global cities, where foreign investment has driven up property prices and rents, exacerbating housing affordability challenges. Despite its economic benefits, Foreign Real Estate Investment (FREI) often makes homeownership less attainable for local residents, leading to varied government responses. While some case studies have explored this issue on a localized level, a large-scale, comparative analysis remains absent. This project addresses this gap by investigating the impact of FREI on housing affordability and homeownership across 50 countries, using a comparative political economy approach. The study will analyze divergent regulatory approaches and evaluate their effectiveness in managing FREI’s effects on housing markets. Using advanced econometric methods like Vector Autoregression (VAR) and Instrumental Variable (IV) models, and developing two original datasets—Foreign Real Estate Investment Index (FREI) and Foreign Real Estate Investment Regulation Index (FREIR)—this research will provide a comprehensive analysis of the complex interactions between foreign investment, housing market dynamics, and regulatory frameworks. The findings will offer critical insights for policymakers to develop strategies that balance the benefits of foreign investment with the need for affordable housing.

Keywords: foreign real estate investment housing affordability government regulations comparative political economy housing financialization political economy of housing homeownership
Lithium based Innovation for Modular Energy (LIME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Research and Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: France,Germany,Spain
Call: Design and Integration of a High-Performance Battery System on a Hybrid-Electric Regional aircraft (HORIZON-JU-Clean-Aviation-2025-01F, 2025)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 4999000.0
EU funding (EUR): 4999000.0
Participants: 7
Project status: SIGNED

LIME project, led by Ascendance (France), expert in hybrid electric propulsion technologies for aviation and aircraft integration), unites EXOES (France), an expert in thermal integration and battery packaging mainly for non-aeronautics sectors, RWTH Aachen University (Germany), a research organization renowned for battery engineering expertise, BASQUEVOLT (Spain) a pioneer in solid state battery cell technology) and the end-users (associated partners) ATR, AIRBUS, and DAHER. LIME aims to develop and demonstrate a TRL 4 battery system for hybrid-electric propulsion in Ultra-Efficient Regional Aircraft, targeting entry into service by 2035, with potential spin off to the SMR aircraft. Addressing the decarbonization of aviation, LIME objectives include (1) ensuring a safety-conforming, end-user-centric battery system; (2) designing a state-of-the-art battery system meeting CS25 needs; (3) prototyping a TRL4 battery system; (4) promoting flexibility and agility via a digital twin; (5) paving the way for EIS in 2035; and (5) maximizing the project's impact and benefits to Europe. The key innovations central to LIME and its partners include: Basquevolt's disruptive solid-state cell technology which offers enhanced safety and energy density; Exoes's advanced thermal management (immersive cooling) that ensures optimal battery performance; and Ascednance's, lightweight and safe composite casing which is vital for aviation applications. The methodology begins with defining the battery system requirements (from end users needs and safety requirements), followed by a preliminary design phase and a detailed design phase that cover these requirements. After validation, prototyping begins along with thorough testing. It ends with a synthesis of the project and its conclusions, assessment of integration options in regional aircraft and a roadmap to reach TRL 9 & EIS in 2035 of the product. The project is expected to last 24 months, and the consortium is asking for €5M.

Keywords: sustainable aviation hybrid electric propulsion ultre efficient aircraft regional aircraft battery system battery pack battery design battery prototype battery testing aviation grade battery
Deciphering subsurface carbon fixation (SUBCARB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Despite containing the vast majority of carbon on the planet, the Earth’s subsurface represents a mostly uncharacterized frontier for biogeochemistry and microbial ecology. While carbon fixation at the Earth’s surface has been drawing a lot of attention for decades, subsurface carbon fixation remains poorly understood. Yet, metabolically, it engages a rich diversity of non canonical pathways, contrasting to surface carbon fixation dominated by the canonical Calvin cycle. Also, its contribution to the global carbon cycle, though long overlooked, is now garnering increased attention. In recent years, several studies aiming to characterise the diversity of carbon-fixing organisms within the subsurface have emerged. However, these studies are isolated and do not accurately describe the dependence of these metabolisms on the geoenvironmental context. I propose here to provide a blueprint of subsurface carbon fixation on Earth. In a top-down approach, I will systematically sample various subsurface environments for metagenomic and metaproteomic analysis of carbon fixing metabolisms, in search of the main environmental factors determining the carbon fixation strategy used. In parallel to this, I will undertake a bottom-up experimental approach to explore and confirm this metabolic versatility in response to changing environments, through controlled culturing experiments. Finally, I will integrate the acquired results with stable isotope analysis to build a metabolic model, aiming to comprehensively predict carbon fixation fluxes in function of the geoenvironmental context. The proposed holistic approach will increase our understanding of the role of subsurface microbial metabolisms in global carbon cycling.

Keywords: carbon fixation subsurface environments metagenomics metaproteomics flux balance analysis
Operator-Centered Enhancement of Awareness in Navigation (OCEAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Norway,Greece,Ireland,United Kingdom,Spain,Denmark,Portugal
Call: Safer navigation and tackling containership fires (HORIZON-CL5-2022-D6-01, 2022)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 5940818.74
EU funding (EUR): 4992165.0
Participants: 14
Project status: SIGNED

The OCEAN project approach is to contribute to the mitigation of navigational accidents by supporting the navigators to do an even better job than they do presently. Such support does not only relate to an ‘on-the-spot’ enhancement of navigational awareness – including the presence of marine mammals and floating containers – or an improved performance of evasive manoeuvring and other mitigating actions. The project will go both deeper and wider, to identify and suggest amendments or improvements in the most pertinent factors that may contribute to events becoming accidents: training, technical, human or organisational factors, operational constraints, processes and procedures, commercial pressures or structural issues like shortcomings in rules and regulations. From an implementation perspective, the OCEAN project will develop new design methods and operational processes, as well as integrating existing technologies to provide novel and improved functionalities. A key convergence point is the overall navigation situation assessment made by the operator, and the project aims at providing an integrated and designed-for-the-purpose presentation of near-field threats and navigational hinderances. The project outputs will include an Evasive Manoeuvring Agent, intended to work in tandem with existing ship systems, continuously assessing navigational safety with respect to grounding or collision with other ships, fixed structures or other threats, and the visualization of advanced manoeuvring prediction. OCEAN will suggest the creation of a European Navigational Hazard infrastructure to collect, process and distribute data relating to the presence of marine mammals and floating containers. Further innovations comprise input to upcoming and revised international standards for maritime communications and practical methods to design maritime instruments and devices, all of which will be demonstrated in consolidated scenarios.

Keywords: maritime safety,human centred design,situation awareness,navigational accidents
Exploring the structure and function of NUDT5 in de novo purine synthesis (purine synthesis)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Proliferation of tumour cells requires continuous DNA synthesis and energy supply. Purine nucleotides are essential building blocks for DNA. Recent research has highlighted the role of NUDIX hydrolase 5 (NUDT5) catalytic activity in nuclear ATP metabolism in breast cancer. Notably, NUDT5 has also been suggested as a more general prognostic marker for various cancers, and NUDT5 depletion leads to suppression of tumour cell proliferation in a variety of model systems. Strikingly, the host lab has recently discovered that NUDT5 possesses an unexpected non-enzymatic, likely scaffolding role in de novo purine synthesis. This observation is unprecedented for a catalytically active member of the NUDIX family. In this project, I aim to dissect the molecular mechanism and reveal the structural basis of NUDT5-regulated purine metabolism by combining Affinity Purification Mass Spectrometry (AP-MS) proteomics and metabolomics with X-ray crystallography and cryogenic Electron Microscopy (cryo-EM) with three main goals: (1) Unravel the molecular mechanism and role of NUDT5 in purine synthesis using a comparative metabolomics and proteomics approach using CRISPR knock out (KO) cell lines, small molecule inhibitors and degraders of NUDT5 in relevant cell line models. (2) Identify and define the NUDT5 interactome via AP-MS, and validate candidate NUDT5 interactors in biophysical and functional assays using purified proteins and cellular models. (3) Explore NUDT5 protein complexes using X-ray crystallography and cryo-EM to dissect the molecular interaction between NUDT5 and complex partners for regulation of purine synthesis. This work will offer novel fundamental insights into the molecular mechanism of NUDT5-mediated purine metabolism, and the scaffolding role of this enzyme to provide new perspectives on cellular metabolism and potential anti-tumour drug development.

Keywords: cellular metabolism purine synthesis cancer therapy nudt5 structure
Van der Waals materials for integrated nanophotonics (VALERIA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Germany,Poland,Sweden,Israel
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-05-01
End date: 2029-04-30
Duration (months): 48.0
Total project cost (EUR): 3270983.75
EU funding (EUR): 3270983.75
Participants: 7
Project status: SIGNED

Integrated quantum photonics is pivotal for the implementation of quantum technologies and their transition from a laboratory to a real-life context. The building blocks of a photonic circuit may comprise one or more single photon emitters (SPEs) and diverse components, such as waveguides, beam splitters, interferometers etc. required for steering and processing the quantum signals produced by the sources. In order to minimise the circuit size and energy consumption, photonic circuits should integrate as many components as possible on a same chip. Currently, it is extremely challenging finding a single material that can be used both as SPE and medium in which the single photons are transmitted. The long-term vision of VALERIA is the achievement of a single-material platform for the realisation of on-chip photonic quantum devices exploiting the nanostructurisation of van der Waals crystals. Our final goal will be the fabrication of a device made of a single non-centrosymmetric transition metal dichalcogenide bulk crystal embedding site-controlled SPEs deterministically integrated with photonic crystal cavities and coupled to electric-field configurable waveguides/beamsplitters.

Keywords: two dimensional materials,single photon emitters,photonic circuits