Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MELanoma GENetics - understanding and biomarking the genetic and immunological determinants of melanoma survival (MELGEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Norway,Sweden,Netherlands,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-06-01
End date: 2019-12-31
Duration (months): 55.0
Total project cost (EUR): 3988365.84
EU funding (EUR): 3988365.84
Participants: 6
Project status: CLOSED

MELGEN (MELanoma GENetics) – understanding and biomarking the genetic and immunological determinants of melanoma survival The MELGEN European Training Network (ETN) will create an environment for long-term, collaborative, inter-sectorial cancer genetics research with the ultimate aim of improving precision (personalised) medicine. In a 2012 report the European Science Foundation identified the importance of precision medicine and recommended that there should be 1) provision of comprehensive, accessible and interoperable datasets 2) improved models and decision-making processes, 3) interdisciplinary, public-private partnerships and translational research, and 4) dedicated funding including access to core technology and frameworks for education and training of professionals. This application addresses all four recommendations and applies them to melanoma. Considerable, but insufficient, progress has been made in understanding the genetic changes within melanomas that drive tumour progression, and how those drivers can be targeted to treat melanoma. Melanoma is also an especially immunogenic cancer and much more needs to be understood of how melanomas suppress host immunological responses. Understanding what controls immunity in melanoma will be potentially applicable to other cancers. Finally, we need prognostic and predictive biomarkers for selection of precision therapy. This ETN will recruit 15 early stage researchers (ESRs) to address these issues. It will bring together leaders in clinical research, genomics, statistics, bioinformatics, and the biotech industry to exploit the new genomic tools and tumour immunology. MELGEN’s commercial partners are developing immunological tests (ImmunID), bioinformatics (Eagle Genomics), commercial genomics (ServiceXS) and digital design/communications (Digitronix) and they will underpin an innovative, interdisciplinary training programme for the next generation of melanoma researchers.

Keywords: melanoma,melanoma specific survival,immunological responses to cancer
Integration of retinal inputs by distinct collicular cell types (RETICULUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Animals have a diverse set of behaviors that are triggered by specific sensory stimuli, such as motion or looming. In the visual system, this process begins in the retina where the visual scene is divided into 20 parallel information channels before reaching the brain. The superior colliculus is one of the main recipients of retinal output and it mediates tractable visually-guided behaviors such as eye movement, orienting or escaping behaviors. However, it remains unknown how visual signals from individual retinal ganglion cell types are processed by neurons in the superior colliculus to achieve specific computations relevant to behaviors. To answer these questions, I will use transgenic mouse lines recently identified by the host laboratory, in which specific types of retino-recipient neurons of the superior colliculus are labeled with Cre recombinase. First, I will characterize the response properties of Cre-labeled individual cell types using in vivo two-photon calcium imaging during visual stimulation. Next, I will initiate calcium sensor-functionalyzed trans-synaptic viral tracing from Cre-labeled collicular cell types, and perform two-photon calcium imaging of labeled presynaptic retinal ganglion cells and starter collicular neurons. With this approach I will relate the activity of neurons to the activity of connected neuronal networks, and evaluate the degree of convergence and divergence in retino-collicular connectivity. By linking cell types, circuits and computations, this work will provide mechanistic insight into the circuit basis for parallel processing of visual information and various visual functions in the healthy system, while possibly disclosing novel therapeutic targets for visual motor diseases.

Keywords: superior colliculus,retinal ganglion cells,visual processing,visual circuits,trans synaptic viral circuit tracing,two photon calcium imaging
Fashioning Heads: Valorising Novelty in Eighteenth-Century France (AXIONOVI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 175673.28
EU funding (EUR): 175673.28
Participants: 1
Project status: CLOSED

This research investigates innovatory practices and the importance of novelty in eighteenth-century France by considering the specific case of fashion in women’s coiffures. At the crossroads of cultural and material history, it will examine how the search for novelty governed the coiffures trade and how these practices contributed to shape the concept of novelty, at a crucial moment when it became a core attribute of modernity. By focussing on the innovatory strategies of the different actors involved in the creation and the commercialisation of fashionable coiffures, the research will attempt for the first time to map a field, which is still uncharted despite its importance during the Ancien Régime. Drawing on a wide range of primary sources, from merchants’ account books to fashion plates and advertisements, and combining different historiographical approaches, this project will shed light on the relations between merchants in different trades, fashion journal editors, customers and government agencies. The investigation will also address the importance of novelty in global trade and foreign imaginaries, by analysing the relationship between economic and symbolic conceptions of value. This undertaking will reassess the role of fashion in the culture and economy of eighteenth-century France: through new archival research it aims to re-connect fashion with the wider philosophical and economic reflexion on the notion of novelty in the Ancien Régime The project also includes a practical component through the recreation of historical coiffures in a fashion museum. This hands-on research methodology, documented in a blog, will not only offer a better understanding of how these hairstyles were made, but it will also reflect on the utility of re-creation both in historical research and in museum exhibitions. Thus, this investigation will propose an embodied critical reflexion on the value of novelty, a timely attempt to address an issue in urgent need of historicization.

Keywords: material history of fashion,history of coiffure,18th century french studies,history of value,axiology,practices of innovation
An Effective Microwave-Assisted Extraction Process for a Natural Biostimulant Blend (Tydo-Stimulant)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As the global population grows, there is an increasing need to secure food production in a sustainable manner. One of the most promising innovations in agriculture, is the use of plant-beneficial microorganisms and substances known as biostimulants. The use of biostimulants in has demonstrated great potential but current methods of biostimulant production yield low levels of biostimulant (grams), which makes widespread adoption difficult. Biostimulant producing companies currently face difficulties in extracting policosanols and TRIA from natural sources, in large quantities and at reasonable production costs. For industrial production of policosanols, only sugar cane, bees wax and fabaceae have proved promising. Sugar cane contains very low amounts of TRIA and the supercritical CO2 used to extract natural triacontanol content from Fabaceae is very expensive. The conventional extraction process from beeswax takes several hours and is resource-intensive. In response, Tydock Pharma, is upscaling an efficient biostimulant extraction process and a new potent biostimulant blend from beeswax. We are working in collaboration with pharmaceutical, agronomy, and research institutions to ensure success upscaling of our production process. Our production process is green, with no toxic by-products and has the potential to increase biostimulant production from current yields of a few grams to kilograms per cycle, enabling the universal application of biostimulants in increasing global food production, naturally. The production cycle is 20 minutes, which is more than 12 times faster than conventional production methods. This enables us to produce 98% more biostimulant than our competitors. We expect average cumulative profits of 15.2 million. A ROI of €10.9 per euro invested and 7 new employees for the first 5 years of commercialisation. We anticipate that by year 5, we would have captured 3.6% of the European biostimulant market share.

Keywords: biostimulant,extraction process,zero by products,beewax,tria,high yields
Acousto-Magnetic Micro/Nanorobots for Biomedical Applications (SONOBOTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1484839.0
EU funding (EUR): 1484839.0
Participants: 1
Project status: SIGNED

Micro/nanorobots can transform many aspects of medicine by enabling tasks, such as delivering drugs or genes precisely to targeted areas, transducing force on individual cells or tissues, performing biopsies, and facilitating non-invasive surgeries. Numerous propulsion mechanisms have been developed, but their low propulsion speed, lack of biocompatibility, and poor navigation capabilities have limited their use. The objective of this proposal is to develop wireless micro/nanorobots using acoustic and magnetic actuation modalities that will be used to navigate in microfluidics and zebrafish disease models to help better understand and treat diseases. The combination of ultrasound and magnetic fields is capable of overcoming the limitations encountered using a single actuation technique, and both are used extensively in clinical diagnostics and therapeutics. This proposal is divided into three research areas. 1) To date, no systematic studies have been conducted utilizing micro/nanorobotics on living animals. The research will address many of the fundamental challenges of using micro/nanorobots in living animals, followed by testing in microfluidics, 3D arbitrarily-shaped fluidic devices, and the vasculature of zebrafish embryos. Propulsion will be studied in the direction of and against blood flow, a 3D propulsion will be developed, and a swarm of nanorobots will be studied. 2) A platform will be developed that involves the trapping and manipulation of nanorobots in an animal model, such as zebrafish embryos. 3) We will develop an active drug delivery platform combined with other methods to study numerous disease models using the models based on live zebrafish embryos. We believe the results of the proposed research will have a significant impact in the field.

Keywords: nanorobots,ultrasound,acoustics
Evolutionary genomics of royalty in Messor hybridogenetic ants (RoyalMess)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Royalty in social insects is typically environmentally acquired rather than genetically determined. However, this is not the case in an exceptional reproductive system, known as social hybridogenesis. Here, two distinct royal lineages of ants can only produce queens by their own while they need to hybridize to produce workers. Eggs with a pure royal genome are thus genetically fated to become queens while hybrid genomes are fated to become workers. Convergent evolution toward such a baroque reproductive strategy appears common in harvester ant species (four times in Pogonomyrmex and Messor genera), but its origin is still completely mysterious. In this project, I plan to unravel the evolution of this unique system via cutting-edge genomic and molecular approaches. 1. Prevalence of social hybridogenesis: I will use genome-wide sequence data to identify novel occurrences of social hybridogenesis across ~500 ant species, in search for potential ecological determinants (e.g. climate or diet) that could favour evolution towards genetic caste determination. 2. History of royal lineages: I will use population genomics in three pairs of Messor royal lineages to trace back their evolutionary origin. For this, I will develop a novel ABC method to map introgressions and selective sweeps along royal lineage genomes to detect past hybridization events or fixation of potentially selfish caste-biasing alleles. 3. Identifying caste-determining genes: I will use comparative transcriptomics in early ant embryos to identify genes differentially expressed between castes before developmental divergence. Candidate genes will be experimentally validated via i) controlled matings between pure-lineage queens and lab-produced recombinant males and ii) genome editing via the CRISPR-Cas9 technology. If successful, this project will enable the first genetic manipulation of ant royalty, deciphering how such an iconic example of phenotypic plasticity can become genetically hardwired.
Individuals, social identities and archetypes – the oldest Scandinavian personal names in an archaeological light (ArcNames)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2021-06-16
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

This project sets out to investigate the relation between personal names, social identities and social status in Scandinavia, ca. 300 - 800 AD. The project is called ArcNames and it aims to rethink the evidence of Late Iron Age and Viking Age personal names and their contexts by putting them into an up-to-date archaeological framework. The ArcNames project has two main objectives. First, it will create a better understanding of individual naming and the construction of personal and social identities in the Scandinavian Late Iron Age and Viking Period mainly by investigating the correspondence between names and archaeological evidence relating to identity. Therefore, the first part will assess the motives expressed in personal names and how these correspond with identities expressed in iconography, burial assemblies and runic inscriptions. Secondly, these issues will be evaluated in relation to the archaeological understanding of status and landholding, especially through a discussion of the use of personal names in place names and runic inscriptions. The second part thus will investigateshow personal names occuring in place names express status and ownership structures and help to understand the social aspects of Late Iron Age and Viking period settlement patterns. A prominent theme in the investigations will be the perceptions of women and land ownership or power structures in relation to gender. The project will work to build an interdisciplinary research environment around onomastics and archaeology at the University in Bergen in connection with the new establishment of the Norwegian Language Collections here. At the same time, it contains a plan to train the fellow in archaeological research skills, university teaching and research management.

Keywords: personal names,iconography,burial customs,iron age,scandinavia,settlement structure,land holding
Stochastic pattern formation in biochemical systems (STOPATT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2023-01-29
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

There are basically three mechanisms for spatial pattern formation in systems of two coupled reaction-advection-diffusion equations; the Turing patterns, patterns created through reaction kinetics, and chemotaxis patterns. We are interested in the reaction-diffusion equation with underlying chemotaxis. The terminus chemotaxis refers to oriented movements of cells (or an organism) in response to a chemical gradient. The topic of the proposal to investigate the logistic grow equation with underlying chemotaxis. This system will be perturbed by a stochastic noise term, modelling neglected fluctuations or random perturbations from outside. The stochastic term leads to new phenomena, e.g. bifurcation are smeared out, metastability may happen, or sudden shifts to other, possible undesired, states. First, the existence and uniqueness of the solution should be investigated; then the long term behaviour will be analysed. Here, also the dynamical behaviour should be characterised. The third point, we will focus on is the numerical approximation of the system.

Keywords: stochastic analysis,stochastic partial differential equations,mathematical biology,pattern formation,stochastic cross diffusion
Super Variable Vector Combination Energy Saving Hub (SuperEH)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Israel
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-10-01
End date: 2020-03-31
Duration (months): 30.0
Total project cost (EUR): 2456627.5
EU funding (EUR): 1719639.25
Participants: 1
Project status: CLOSED

SuperEH is a turn-key integrated solution of Smart Voltage Optimization with Loads Management and Analytics yielding energy savings from 15% to 25%. SuperEH is suitable for a broad range of buildings, industrial and commercial facilities such as supermarkets, restaurants, convenience stores, hotels and other food related business and industries. Our technology is especially suitable for this kind of facilities due to the mixture of energy loads typically found. Additional benefits of the product are easy installation, extension of consuming devices lifetime, reduction of maintenance costs and improved operational safety. SuperEH is straightforwardly applicable in an existing building; it is installed at main switchboards with no interruption to the facility operation and no change to the existing infrastructure. Both features are highly desired in our market niche. PowerSines is developing this new product as response to market demands of tools for electricity cost reduction .With this project, we aim to enhance SuperEH functionalities, making our value proposition of highest energy savings (up to 25%) and shortest payback period (below 2 years) unique in the European market. The market niche in which SuperEH is expected to find no rival technology has been estimated at 973 M€/year in 2023. Our goal is to launch SuperEH to the European market reaching 42 M€ accumulated during five years of sales. PowerSines is a leader in the field of Voltage Optimization for the efficient management of electricity in commercial sites and buildings. Our track record includes more than 25,000 installed units across Europe. This project will allow expanding our customer base and our partner network across Europe. During the project, we will validate the product upgrades across 10 countries in Europe and demonstrate that SuperEH is an excellent tool towards CO2 reduction in the buildings sector, with the highest ratio of tons reduced per € invested available nowadays.

Keywords: voltage optimization,energy loads,energy efficiency management,energy performance,energy management systems,building energy management systems,bems