Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research (INTREALL)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Switzerland,Czechia,Austria,France,Portugal,Belgium,Sweden,Denmark,Finland,Norway,United Kingdom,Netherlands,Italy,Israel,Poland,United Kingdom,Germany,Netherlands,Spain,United States,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-10-01
End date: 2017-09-30
Duration (months): 72.0
Total project cost (EUR): 7763823.76
EU funding (EUR): 5998055.0
Participants: 29
Project status: CLOSED

Though survival of children with acute lymphoblastic leukaemia (ALL) has improved, relapse remains a leading cause of mortality in childhood cancer. Given the rarity of the disease, only a large international cooperative group can recruit sufficient patients for prospective studies with specific questions in biologic subgroups. Under the umbrella of the I-BFM SG all relevant mainly European study groups are creating the worldwide largest Study for Children with Relapsed ALL (IntReALL 2010). The aim is to develop optimized standard treatment as platform for systematic randomized phase II and III studies on the most promising new and targeted agents. An adequate trial structure, an optimized web based database, and standardized diagnostic methods need to be established. Patients are stratified into a standard (SR) and a high risk (HR) group according to established factors. For SR patients, the best available treatment protocols ALL-REZ BFM 2002 and ALL R3 are randomly compared, and the additional effect on survival of the humanized monoclonal CD22 directed antibody epratuzumab is investigated. HR patients who have unsatisfying remission rates will receive an intensified induction with the proteasome inhibitor bortezomib randomly combined with standard induction therapy. IntReALL 2010 allows for comprehensive tumour banking and systematic biologic research in subgroups with correlation to clinical outcome. SMEs will be involved into project management, data base development, and pharmaceutical and biotechnological research to ensure innovation in the respective areas. IntReALL 2010 is embedded in a network of European academic structures relevant for childhood cancer. It will be a cornerstone of drug development in childhood leukaemia and the only trial with the potential for well powered phase III studies in this indication. IntReALL 2010 will harmonize ALL-relapse therapy, establish highest diagnostic and therapeutic standard and improve survival of children with ALL.

Keywords: childhood relapsed all,phase iii study,optimized standard treatment,new agents,networking
Exploring Chemical Reactivity with Organocatalysis (ORGA-NAUT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Spain
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The proposed research seeks to redefine the synthetic potential of a fundamental organic transformation: the functionalisation of carbonyl compounds. Today, synthetic chemists can address even the most daunting of challenges connected with the asymmetric catalytic functionalisation of carbonyl compounds at their alpha and beta positions. In contrast, there are no known general strategies for the corresponding direct, catalytic and enantioselective transformation to a carbonyl group at the gamma position. By developing innovative methodologies to effectively address this issue, I will provide a novel reactivity framework for exploring unprecedented transformations. This would strengthen the chemistry toolbox to better face the challenges of modern organic chemistry. I will proceed by combining asymmetric aminocatalysis (a versatile chemical strategy whose potential has not yet been fully explored) with photoredox catalysis driven by visible light. This will provide access to open-shell radical species, which participate in bond constructions that are unavailable using amine organocatalysis alone. Since electron-deficient radicals are known to rapidly react with pi-rich olefins to forge even the most elusive C-C bonds, mild and catalytic approaches to accessing these reaction manifolds offer desirable opportunities for designing new gamma-functionalisations of carbonyl compounds. Developing an innovative system based on a chiral organic catalyst that efficiently harnesses the energy of solar radiation is in line with the European approach to attaining Sustainable Chemistry, one of the central scientific goals of the 21st Century. This proposal challenges the current paradigms for stereoselective functionalisation by providing a template for directly functionalising unmodified carbonyl compounds at their gamma positions, expanding the way chemists think about making chiral molecules

Keywords: organocatalysis,photoredox catalysis,asymmetric synthesis,radical chemistry
Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer (THE GRAIL)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Italy,Spain,United Kingdom,Spain,Italy,Netherlands,Switzerland
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 7804024.0
EU funding (EUR): 5998438.0
Participants: 9
Project status: CLOSED

The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ischemia in feed arteries of the diseased organs. These organs include the brain (ischemic stroke), the heart , the kidneys, the gastrointestinal tract, the lower limbs (leading to amputations, especially in diabetic patients). The purpose of the in vivo tissue engineered (TE) blood vessel is to offer an alternative treatment for patients affected with this disease: to substitute the actual mechanical, acute oriented “rechanneling” or “by passing” of obstructed arteries with a regenerative, physiological, disease solving and long term oriented, approach in the therapy of ischemic cardiovascular disease, compatible with today minimal invasive surgical techniques. This is an unexplored area of approaches of therapy for arterial obstruction by TE technology: the substitution of the diseased arterial intima (atherosclerotic plaque removed) with an absorbable bioactive scaffold, called the synthesized intimal layer (SIL), to be repopulated by resident and circulating patient resident and stem cells. SIL does not intend to stent the artery; conversely it aims to replace the diseased and stiffened area with a soft and compliant intelligent scaffold that becomes reabsorbed once its task is completed , leaving a physiologically responsive regenerated tissue. The project aims to merge the single laboratories ongoing work, coordinate it and finalizing it to bring it through the whole pre clinical process, including the whole regulatory work, the GLP animal pre clinical implants and the design and production of “TE device” deployment technology.

Keywords: cardiovascular disease,rigenerative medice in artheries,in vivo tissue engineering,endovascular technology
Analytic-probabilistic methods for borderline singular integrals (ANPROB)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Finland
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1100000.0
EU funding (EUR): 1100000.0
Participants: 1
Project status: CLOSED

The proposal consists of an extensive research program to advance the understanding of singular integral operators of Harmonic Analysis in various situations on the borderline of the existing theory. This is to be achieved by a creative combination of techniques from Analysis and Probability. On top of the standard arsenal of modern Harmonic Analysis, the main probabilistic tools are the martingale transform inequalities of Burkholder, and random geometric constructions in the spirit of the random dyadic cubes introduced to Nonhomogeneous Analysis by Nazarov, Treil and Volberg. The problems to be addressed fall under the following subtitles, with many interconnections and overlap: (i) sharp weighted inequalities; (ii) nonhomogeneous singular integrals on metric spaces; (iii) local Tb theorems with borderline assumptions; (iv) functional calculus of rough differential operators; and (v) vector-valued singular integrals. Topic (i) is a part of Classical Analysis, where new methods have led to substantial recent progress, culminating in my solution in July 2010 of a celebrated problem on the linear dependence of the weighted operator norm on the Muckenhoupt norm of the weight. The proof should be extendible to several related questions, and the aim is to also address some outstanding open problems in the area. Topics (ii) and (v) deal with extensions of the theory of singular integrals to functions with more general domain and range spaces, allowing them to be abstract metric and Banach spaces, respectively. In case (ii), I have recently been able to relax the requirements on the space compared to the established theories, opening a new research direction here. Topics (iii) and (iv) are concerned with weakening the assumptions on singular integrals in the usual Euclidean space, to allow certain applications in the theory of Partial Differential Equations. The goal is to maintain a close contact and exchange of ideas between such abstract and concrete questions.

Keywords: harmonic analysis,singular integrals,weighted norm inequalities,local tb theorems,probabilistic methods,martingales,analysis on metric spaces,nonhomogeneous analysis,random dyadic cubes
Interactive Systems Involving Multi-point Surfaces, Haptics and true-3D displays (INTERACT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1419636.0
EU funding (EUR): 1419636.0
Participants: 2
Project status: CLOSED

The grand challenge of this project is to 1) develop integrated multi-point surfaces that include multiple touch points, multiple haptic feedback on fingers (and tangible objects on the surface) and reconfigurable ‘true-3D’ content for a ‘walk-up and use’ scenario; 2) identify interaction design principles and visualization techniques to support users around such surfaces and 3) demonstrate the added value of this multi-point surface by integrating this within the workflow of stem-cell researchers to demonstrate that better visual and mechanical characterization of biological processes is achievable with our system. The knowledge generated can be applied to a wide range of applications from entertainment and education to medical and life-sciences. For example, with our proposed system students can collaborate around an interactive table to feel plant textures and human organs while visualizing them in 3D while discussing with fellow students to allow for a very rich learning experience.

Keywords: user interfaces,multi-point surfaces,haptics and volumetric displays
Memory Compositional Abstract Domains: Certification of Memory Intensive Critical Softwares (MEMCAD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2017-09-30
Duration (months): 72.0
Total project cost (EUR): 1489663.0
EU funding (EUR): 1489663.0
Participants: 1
Project status: CLOSED

Every year, software bugs cost hundreds of millions of euros to compagnies and administrations. A number of disasters such as the Ariane 5 first flight failure can are due to faulty softwares. Static analysis aims at computing automatically properties of softwares, so as to prove they are exempt from some class of bugs. In the last ten years, static analysis of numeric intensive applications improved dramatically so that the certification of safety properties like the absence of runtime errors in industrial size control-command, numeric intensive applications, such as Airbus fly-by-wire softwares is now feasible. By contrast, the situation is much worse for memory intensive softwares. Existing static analyzers for such softwares do not scale to large scale softwares, and fail to prove strong invariants on large classes of softwares. These limitations stem from the fact they use a monolithic algebra of logical formulas (or abstract domain). Our proposal is based on the observation that the complex memory properties that need be reasoned about should be decomposed in combinations of simpler properties. Therefore, in static analysis, a powerful memory abstract domain could be designed by combining several simpler domains, specific to common memory usage patterns. The benefit of this novel vision is twofold: first it would make it possible to simplify drastically the design of complex abstract domains required to reason about complex softwares, hereby allowing certification of complex memory intensive softwares by automatic static analysis; second, it would enable to split down and better control the cost of the analyses, thus significantly helping scalability. This shift of focus will bring both theoretical and practical improvements to the program certification field. We propose to build a static analysis framework for reasoning about memory properties, and put it to work on important classes of applications, including large safety critical memory intensive softwares.

Keywords: software verification,static analysis,abstract intepretation,memory properties
Reconstructing abrupt Changes in Chemistry and Circulation of the Equatorial Atlantic Ocean: Implications for global Climate and deep-water Habitats (CACH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2017-09-30
Duration (months): 72.0
Total project cost (EUR): 1998833.0
EU funding (EUR): 1998833.0
Participants: 1
Project status: CLOSED

Ice-core records show that glacials had lower atmospheric pCO2 and cooler temperatures than today and that the last deglaciation was punctuated by large, abrupt millennial-scale climate events. Explaining the mechanism controlling these oscillations remains an outstanding puzzle. The ocean is a key player, and the Atlantic is particularly dynamic as it transports heat, carbon and nutrients across the equator. This project proposes to consolidate my research through a focused study of present and past ocean chemistry in the Equatorial Atlantic and to assess the impact of ocean chemistry on fragile deep-sea ecosystems. Despite decades of research there are distinct gaps in our knowledge of the history of the deep and intermediate ocean. Major hurdles include access to suitable archives, development of geochemical proxies and analyses that are sufficiently precise to test climate hypotheses. Through a combination of ship board field work, modern calibrations and cutting-edge geochemical analyses this project will produce samples and data that address each of these gaps. A particular focus will be on using the skeletons of deep-sea corals. Research using deep-sea corals as climate archives, and indeed research into their habitats, environmental controls and potential threats to their survival are still fields in their infancy. The expense and logistics of working in the deep ocean, the complexity of the ecosystem and the biogeochemistry of the coral skeletons have all proved to be significant challenges. The potential payoffs of high-resolution, dateable archives, however, make the effort worthwhile. There have been no studies that attempt to match up co-located deep-sea coral, seawater and sediment samples in a single program, so this would be the first directed study of its type, and as such promises to provide a substantial step in quantifying the fluxes and transport of mass, heat and nutrients across the equator in the past.

Keywords: deep-sea corals,ocean circulation,radiocarbon,proxy development
Transparent communication in Epidemics: Learning Lessons from experience, delivering effective Messages, providing Evidence (TELL ME)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: France,United Kingdom,Italy,Belgium,Israel,United Kingdom,Latvia,United States
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-02-01
End date: 2015-01-31
Duration (months): 36.0
Total project cost (EUR): 2499811.56
EU funding (EUR): 1900342.25
Participants: 12
Project status: CLOSED

TELL ME (Transparent communication in Epidemics: Learning Lessons from experience, delivering effective Messages, providing Evidence) is a 36 month Collaborative Project, which aims to provide evidence and to develop models for improved risk communication during infectious disease crises. TELL ME combines public health, social sciences, behavioral sciences, political sciences, law, ethics, communication and media, in order to develop original communication strategies regarding complicated messages and advice based on uncertainties, also addressing vaccine-resistant groups.

Keywords: epidemic,human behaviour,vaccination,communication and media,risks,ethics
Hydrogen from RES: pressurised alkaline electrolyser with high efficiency and wide operating range (RESELYSER)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Germany,Belgium,Denmark
Call:  (FCH-JU-2010-1, 2010)
Start date: 2011-11-01
End date: 2015-04-30
Duration (months): 42.0
Total project cost (EUR): 2888957.4
EU funding (EUR): 1484358.0
Participants: 4
Project status: CLOSED

The project RESelyser develops high pressure, highly efficient, low cost alkaline water electrolysers that can be integrated with renewable energy power sources (RES) using an advanced membrane concept, highly efficient electrodes and a new cell concept. A new concept with a three electrolyte loop system will be developed demonstrating even higher performance than conventional two electrolyte loop systems. This three electrolyte loop system will use a new separator membrane with internal electrolyte circulation and an adapted cell to improve mass transfer, especially gas evacuation. Intermittent and varying load operation connected to an RES will be addressed by improved electrode stability and a cell concept for increasing the gas purity of hydrogen and oxygen especially at low power as well as by a system concept. Electrolysers up to 10 kW with 2 Nm^3/h hydrogen production will be realized in the project. The primary pressure of the electrolyser will be up to 50 bar (without the use of a compressor) to reduce the power loss for hydrogen compression to a minimum. All components of the system will be analyzed for their costs and developed to reduce the system price such that hydrogen can be produced at system costs of 3000 € per (Nm^3/h) plant capacity. An extrapolation to a primary electrolyser pressure of 100-150 bar is considered.

Keywords: pressurised alkaline water electrolyser electrodes e-bypass membrane separator
SOFC CCHP WITH POLY-FUEL: OPERATION AND MAINTENANCE (SOFCOM)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Italy,Finland,Italy,Poland,Switzerland,Germany,Denmark,Spain
Call:  (FCH-JU-2010-1, 2010)
Start date: 2011-11-01
End date: 2015-04-30
Duration (months): 42.0
Total project cost (EUR): 6250227.23
EU funding (EUR): 2937752.38
Participants: 11
Project status: CLOSED

If we consider a new energy framework, based on the concepts of sustainability, energy security using local resources, maximization of the exergy efficiency of the whole system, a possible solution could be based on the following criteria: • Combined cooling, heat and power (CCHP) plants; • Small-medium size plants locally distributed; • Plants with maximization of the energy recovery from the primary sources: maximum exergy efficiency of the whole system; • Flexibility in the use of local primary sources (biogas, bio-syngas, bio-fuels); • Easy and efficient CO2 separation from the plant exhaust Among the technologies which could satisfy these criteria, a new technology is gaining more and more interest: energy systems based on Solid Oxide Fuel Cells (SOFC) which, in the medium term, could become one of the most interesting technologies able to address the above criteria. The proposal is an applied research project devoted to demonstrate the technical feasibility and the energy and environmental advantages of CCHP plants based on SOFC fed by different typologies of biogenous primary fuels (locally produced), also integrated by a process for the CO2 separation from the anode exhaust gases. The research activity will address the scientific, technical, economical management of two proof-of-concepts of complete energy systems based on SOFCs, through real in-field demonstration units. Several issues will be pointed out, like high efficiency integration designs, impact of pollutants on SOFC and fuel processing units, gas cleaning, operation in CCHP configuration, carbon sequestration module. The activities developed by each Partner, in the different areas of the proposed research, have the ultimate goal of assembling, testing and validate the two proof-of-concept systems. In order to guarantee the success of the Demonstration activity, it is also integrated with: Lab-scale Activities (preliminary to the real demonstration activities); Conceptual and Analysis Activities

Keywords: sofc,cchp,biogas from waste water treatment,wood gasification gas,co2 removal and management,lab-scale analysis,concept and techno economic analysis,in-field demonstration,operation and test o