Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Point-of-care hematology analyser based on visco-elastic focusing, digital imaging, image processing and machine learning (HemoScreen)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2020-09-30
Duration (months): 28.0
Total project cost (EUR): 3556337.5
EU funding (EUR): 2489436.25
Participants: 1
Project status: CLOSED

HemoScreen is the first true point-of-care hematology analyser: a portable (8kg) and affordable (€4,500) device that can be operated by any medical personnel (no maintenance or calibration). The analyser uses low-cost (€8) disposable cartridges containing a high performance microfluidic chip. The phase 1 market study identified three priority segments for market introduction: physician office labs (POL), oncology and neonatal. In all 3 segments, HemoScreen can reduce the cost of the blood test by at least 50% as physicians can run the test with their own equipment instead of purchasing it from an external lab. More importantly, physicians can get immediate (9 min) results instead of waiting for 24-72 hours, cutting operational inefficiencies, reducing medical transcription errors, improving patient safety, minimizing the time to adequate treatment and ultimately, improving patient outcomes. HemoScreen relies on direct cell characterization based on imaging, the gold standard for cell classification, and a patented visco-elastic focusing method, which is more robust and efficient than hydrodynamic focusing (used in flow cytometry). The technology has already generated 7 patent families and 3 more are expected to be filed during this project. The project will conduct a series of trials involving over 4,000 blood tests over 5 trial sites spread between Sweden, Belgium, UK and USA. The trial results will be used for product improvement, industrialization and certification. Based on preliminary feedback from the FDA, the HemoScreen is the first true hematology POC analyser designed in accordance with CLIA waiver requirements, enabling thousands of physicians to run their own blood tests without requiring any lab certification. PixCell’s vision is to make cell-based diagnostics as simple as a glucose test and revolutionize POC diagnostics. Following a full market launch in 2020, PixCell medical forecasts revenues of €36M and headcount of 85 employees by 2022.

Keywords: point of care,hematology,cell blood count,microfluidics,visco elastic focusing,digital imaging,image processing,machine learning
Cracking the neural code of human object vision (CRACK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-05-01
End date: 2025-01-31
Duration (months): 69.0
Total project cost (EUR): 1480576.0
EU funding (EUR): 1480576.0
Participants: 1
Project status: SIGNED

At each blink of our eyes, our brain rapidly transforms the stream of photons hitting the retina into a conscious percept of the world as consisting of meaningful objects that guide our actions to ensure survival. Yet, in spite of intense research three interrelated, fundamental, long-standing and open questions about how neural dynamics mediate object recognition remain unanswered: How exactly do the core cortical regions active during vision represent objects? How and what do those regions communicate? How does the observed activity mediate adaptive behavior? The overall goal of the program CRACK is to crack the neural code of object vision by addressing those three fundamental questions. For this, CRACK will integrate in an unprecedented manner cutting-edge, non-invasive brain imaging methods, advanced multivariate analysis techniques and state-of-the-art computational modelling in an ambitious three-step interdisciplinary work program. Each step is marked by innovation that breaks new ground and opens new horizons at the next step. First, CRACK will unravel the unique representational format of each core cortical region using an unprecedented brain mapping approach that combines brain imaging with artificial deep neural networks (DNNs). Second, it will clarify the flow of information between visual regions that creates these representations with unseen spatiotemporal precision by resolving neural activity in both cortical layers and frequency channels using a combination of functional MRI (fMRI) and electroencephalography (EEG). Third, it will use advanced multivariate methods linking brain activity and behavior to reveal which aspects of the newly described neural dynamics drive human choice behavior. By breaking down current knowledge boundaries, CRACK will provide the empirical evidence for a new theory of the neural dynamics underlying human visual object recognition, and transform the way we think about and investigate sensory processing.

Keywords: vision,perception,object recognition,fmri,deep neural network
The business engine for IoT pilots: Turning the Internet of things in Europe into an economically successful and socially accepted vibrant ecosystem (Be-IoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Germany,Israel,Germany,Sweden,France
Call: Internet of Things and Platforms for Connected Smart Objects (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 1041073.13
EU funding (EUR): 1041073.13
Participants: 8
Project status: CLOSED

The project IoTBe will be proposed as a support action run by the consortium with the partners etventure, Fraunhofer IAIS, Faubourg Numérique, Acreo Swedish ICT and Challengy Israel. Our vision is to build a broad and vibrant ecosystem around the pilot projects that increase the collaboration between them, generates economic impact through new innovative business models and creates trust in the internet of things by transparent information about social challenges such as privacy and security implications. We will reach this vision by focussing on following five objectives: - We will support the collaboration and knowledge exchange between pilots and other relevant EU-projects (e.g. FIWARE). - We will build the bridge between pilots and relevant stakeholders (e.g. potential customers such as European small and medium sized enterprises (SMEs), entrepreneurs and developers, but also researchers and policy makers) and thus expand the ecosystem further. - We will set the ground for upcoming business building activities by creating awareness and also by facilitating and fostering societal acceptance (e.g. by running a variety of innovation activities). - Building on the above mentioned developments we will set the ground for the development of concrete new customer-oriented businesses based on the emerging pilots. Those business models will be derived through a proven systematic user centric ideation and validation process increasing the market acceptance and success rate of these business models. The emerging new businesses shall have a substantial economic impact in Europe. - We will pave the way for future advances within IoT: We will write a whitepaper that explains, describes and collects the most promising future standards from pilots and distribute these to relevant parties. We will use the consortium existing academies for education activities (e.g. Fraunhofer academy or etventure Berlin School of Digital Business).

Keywords: business engine for iot pilots
SAtellite-based Signalling and Automation SysTems on Railways along with Formal Method and Moving Block validation (ASTRail)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Italy,Italy,Spain,Italy,Belgium,France
Call: Operational conditions of the signalling and automation systems; signalling system hazard analysis and GNSS SIS characterization along with Formal Method application in railway field (H2020-S2RJU-OC-2017, 2017)
Start date: 2017-09-01
End date: 2019-10-31
Duration (months): 26.0
Total project cost (EUR): 1797307.5
EU funding (EUR): 1797307.5
Participants: 7
Project status: CLOSED

The ASTRail project falls within the scope of the topic S2R-OC-IP2-01-2017 – Operational conditions of the signalling and automation systems; signalling system hazard analysis and GNSS SIS characterization along with Formal Method application in railway field, which is connected with the complementary topics S2R-CFM-IP2-01-2015 and S2R-CFM-IP2-01-2017. The ASTRail project will act to enhance the signalling and automation system by searching innovative solutions that exploit cutting edge technologies already present in sectors different from the rail such as the avionics or the automotive sector. Investigation of such technologies and assessment of their reusability in the railway field will be done taking in particular care all issues related to safety and performance in the rail system. Some ASTRail Partners have already participated in S2R projects, while others have been specifically involved to cope with some vertical tasks. From a different point of view, the Consortium is well balanced with both research organizations and industrial stakeholders of the rail domain.

Keywords: automated driving,formal methods,moving block signalling system,hazard analysis
Welcoming Syrian Refugees to İstanbul University: Improving Capacity and Knowledge Sharing (WESREF-IU)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Türkiye
Call: Science4Refugees - Support to highly skilled refugee scientists (H2020-SwafS-2017-1, 2017)
Start date: 2018-05-01
End date: 2019-06-30
Duration (months): 14.0
Total project cost (EUR): 66875.0
EU funding (EUR): 66875.0
Participants: 1
Project status: CLOSED

With the flow of millions of Syrian refugees, Turkish higher education is facing the challenge of including ever growing numbers of refugee students to its system and preparing the system and institutions to their access, participation and inclusion. Although Turkey has taken crucial steps to provide refugees with access to higher education by revising and improving its legal framework, enrollment rates –which is above the world average of %1- are still low and needs further improvement along with the need to focus on their participation both educational and employment level. There is an apparent need to understand the multifaceted, complex needs of refugee students, and to assure their integration into the system. HEIs’ recognition and understanding of the refugee students, researchers would not only contribute to their access and participation to academy, job market, eventual success and empowerment but would further increase the awareness regarding their value and diversity in the society. Therefore. with the aim of increasing effective cooperation with science and society and pairing science with social awareness and responsibility the project oversees the inclusion and participation of refugee students and researchers to HES in Turkey through the piloting of specifically tailored support mechanisms, general staff trainings, good practice and knowledge sharing with increased communication and cooperation.

Keywords: refugee,higher education
Data Portability and Services Incubator (DAPSI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Ireland,Spain,France,France
Call: Next Generation Internet - An Open Internet Initiative (H2020-ICT-2019-2, 2019)
Start date: 2019-11-01
End date: 2022-12-31
Duration (months): 38.0
Total project cost (EUR): 6991193.75
EU funding (EUR): 6991193.75
Participants: 6
Project status: CLOSED

The General Data Protection Regulation (GDPR) applies since 2018, with the purpose of making significantly easier for citizens to have any data which is stored with one service provider transmitted directly to another provider. DAPSI will foster the advanced research in the Data Portability field through the support to researchers, SMEs and high tech startups from all over Europe. DAPSI proposes a match making process: an intersection between science and business, an opportunity to unite the knowledge and experience of both areas to achieve a common goal around Data Portability. To do so, DAPSI consortium will select the best applications to build complementary teams that will research and apply this advancement to relevant uses cases with market potential in a collaborative way. Up to 58 teams will be selected and only the best ones will progress through three phases of 10 months in an incubation programme where experts in diverse field will provide a successful working methodology, access to top infrastructure, training in business and data related topics, coaching, mentoring, visibility, community building and investment. On top of that, each DAPSI team will receive up to 195k€ equity-free funding, distributing a total amount of 5.6M€ through three open calls. The consortium led by ZABALA and participated by F6S, CAP DIGITAL, IMT, FRAUNHOFER and ENGINEERING will also work to contribute to the progress of the NGI community in the Data Portability domain generating insights and recommendations in the field.

Keywords: data portability,talent match,data transparency,data compatibility and security,data analysis
Mineral weathering in the unsaturated zone from the molecular to macro scale (DryMIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-23
End date: 2019-01-22
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

"Mineral weathering in the unsaturated zone from the molecular to macro scale (DryMIN)” Earth’s shallow subsurface, or “critical zone,” is of fundamental importance for supporting terrestrial life and maintaining water quality. Perhaps the most vital part of the critical zone is the unsaturated region located nearest to the surface. It is in the unsaturated zone where most plants acquire their nutrients, and where most organic carbon degrades. This zone is also most likely to be affected by future global change due to altered rainfall patterns and evapotranspiration rates across the globe. In order to predict how long-term variations in the water budget will impact nutrient and carbon cycling it is necessary to evaluate the influence of water saturation on mineral weathering reactions. The objective of the proposed research is to elucidate the fundamental mechanisms governing reaction rates as a function of water availability from the molecular to macro scale. This will be achieved through a combination of three scale-spanning experimental studies: 1) humidity buffer experiments investigating molecular-scale changes to mineral surfaces, 2) pore-scale microfluidic experiments, and 3) macro-scale flow-through column experiments. Experimental results will lead to the development of a mechanistic reactive transport model that can better predict reaction rates as a function of water saturation. This research has significant implications for the maintenance of a sustainable nutrient supply for natural and agricultural vegetation, the carbon cycle, and remediation of groundwater resources, issues critical to the long-term sustainable growth of our society. Through this research programme I will: 1) have opportunities for mobility between multiple institutions in Europe, 2) gain tangible skills in analytical techniques, 3) improve transferable communication and management skills, and 4) establish a lasting multi-disciplinary, collaborative European research network.

Keywords: mineral weathering,climate change,nutrient supply
Molecular basis of avian influenza polymerase adaptation to human hosts (AvINFLUENZA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Due to its high prevalence among birds and high human fatality rate, avian influenza represents a serious and continuing pandemic threat, in particular via mutations that facilitate human infection, resulting in pathogenic strains. Mutations associated with human infection are concentrated in the PB2 subunit of influenza polymerase. This subunit is imported into the nucleus, where viral replication and transcription occurs, via a selective interaction with host importin-alpha proteins. Once in the nucleus, interaction of PB2 with another host protein called ANP32A, has been proposed to play an essential species-specific regulatory role. The behavior of PB2 in solution reveals a high level of conformational flexibility that is essential to function. In addition, intrinsically disordered domains of both ANP32A and importin-alpha are thought to play important roles in the interaction with PB2. This uncommonly high level of disorder presents particular challenges for standard structural studies. This project aims to characterize structurally two protein-protein interactions of the human-adapted PB2 subunit of influenza polymerase with these two human proteins: 1. Importin-alpha 2. ANP32A Highly dynamic complexes such as the targets of this proposal lie outside of the scope of standard methods of structural biology, and are therefore often not described. The high level of flexibility of these systems requires an innovative and integrative structural approach that will combine paramagnetic NMR with techniques such as ensemble methods to describe the conformational equilibria of highly dynamic systems, NMR relaxation dispersion and CEST, SAXS and single-molecule FRET. Through the structural and dynamic characterization of these interactions between human-adapted avian influenza polymerase and two human host proteins, we will contribute to a deeper understanding of viral replication, providing the basic information to facilitate the design of innovative drugs.
Transforming the success of Startups across the EU (VestdSMEProposal)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Vestd is an innovative, disruptive, platform-based enabler of the sharing economy. We are the first company to allow entrepreneur's to found their business with a share structure that enables them to use a portion of their equity to procure services or reward customers in a secure, regulated marketplace. Our platform provides both the equity distribution tool that delivers this and a community of experienced Founders and Contributors to support and invest in each other. Having achieved FCA regulatory approval in the UK (and via the passport system in the EU) in November 2015, we have moved to a proof of concept pilot in the UK during 1H 2016, which has demonstrated that the "equity economy" works, and we are now looking to expand our operations into the EU. This proposal is for funding to support a research project to better understand the issues, barriers and challenges associated with implementing our platform in key european markets during the course of 2017.

Keywords: startups,sharing economy,equity marketplace
Mobile wireless Device microcantilever-based biosensor to identify and measure the aflatoxin B1 in animal food and M1 in the milk-chain (MEDIuM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Italy
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Food safety is actually one of the most burning problems in the agro-food sector. The proposed feasibility study represents the first step to the development and commercialisation of a portable, mobile wireless device, cantilever-based nano-biosensor, to measure in field the B1, M1-aflatoxins to very low level values in animal feedstock and in the milk-chain. The aim is to give a dramatic innovative solution for solving all the problems connected with the high mycotoxins contamination levels checked in animal feed and milk and more in general in the food-chain (reduced growth and fertility, immunosuppression and increasing sensitivity to infections, gastroenteric disorders, ….). Mycotoxins represent a world-wide problem: 25% of cultivation in Europe is contaminated and more than 35% of imported raw material from the rest of the world, particularly from China. This problem could affect a potential market of 5 million farmers and 75000 animal feed producers in Europe The feasibility study output will concern the design of a device and its market positioning with the following innovative features, which are requested by the end-users: - in the field measurement, reliable, fast and easy, transportable. Actually, measurements are possible only in specific environments (i.e Chemical labs). Feed stock producers, breeders and more in general the farmers will be the potential customers. The feasibility study tackles 3 main areas : • Market and patent analysis, for a quick entry in the European market • User needs: a first set of recommendations has been already collected, but a further assessment of the user needs will be carried out, mainly thanks to the cooperation with end users. • Project technological feasibility: through the check of the technological key elements detailed in the description of work The final output of the project will be a detailed Business Plan, containing the Exploitation and Dissemination Plan

Keywords: mobile device,microcantilever,mycotoxins,food quality and safety,animal and human health