Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cooper-pair spectroscopy: A new window into the world of superconductivity (COPS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2974000.0
EU funding (EUR): 2974000.0
Participants: 1
Project status: SIGNED

High temperature superconductivity and other unconventional types of superconductivity, such as topological superconductivity, are central topics in contemporary physics. At the heart of superconductivity lie the pairs of electrons, Cooper pairs, that are formed and condense into a superfluid state below a critical temperature Tc. An outstanding problem is the mechanism that underlies the electron-pairing in unconventional superconductors. Here this problem is addressed by developing a new experimental technique, based on the simultaneous photoemission of both electrons in a Cooper pair by a single photon. Cooper-pair spectroscopy was theorized 20 years ago but has so far never been achieved experimentally. Through numerical simulations it is shown, in this proposal, that using the latest advances in light source technology and electron detection techniques together with software filtering based on the unique properties of Cooper pairs, Cooper-pair spectroscopy can become a reality. Cooper-pair spectroscopy would allow for the direct detection of the building blocks of superconductivity and would thus unequivocally demonstrate the presence of such pairs even in the absence of phase coherence, which is necessary for hall mark effects such as zero resistance or the Meissner effect. Cooper-pair spectroscopy will thus be able to confirm or rule out the existence of preformed pairs above Tc in high-temperature superconductors or in the so called pseudogap phase. Cooper-pair spectroscopy will also permit the measurement of the momentum of Cooper pairs thus allowing for the test of various theories for the superconducting and pseudogap phases of unconventional superconductors. Furthermore, Cooper-pair spectroscopy will allow for the characterization of topological superconductivity as well as the phase transition between topological and non-topological superconducting states. In short, Cooper-pair spectroscopy will open a new window into the world of superconductivity.

Keywords: superconductivity,photoelectron spectroscopy,cooper pairs,cuprates,pnictides
Combining Motion Capture and AI for Home-Based MSD Triage and Care Protocols (KEMTAI-DDX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2400000.0
EU funding (EUR): 2400000.0
Participants: 1
Project status: SIGNED

KEMTAI-DDX introduces a groundbreaking approach to Musculoskeletal Disorder (MSD) management by combining advanced motion capture technology with comprehensive medical questionnaires and patient histories. MSDs affect approximately 1.7 billion people and account for nearly 1:4 physician visits. KEMTAI-DDX's platform facilitates precise home-based triage, rehabilitation, and ongoing monitoring of MSDs, ensuring personalized care delivery. The project aims to validate and optimize the integration of motion capture technology and medical information through retrospective data analysis and clinical trials. By achieving milestones in precision and scalability, KEMTAI-DDX enhances diagnostic accuracy and treatment efficacy. Aligned with EU healthcare priorities, KEMTAI-DDX addresses the rising demand for digital health solutions that streamline MSD management, reduce healthcare costs, and improve patient outcomes. The platform operates on common devices with cameras, ensuring widespread accessibility and integration into existing healthcare systems. Key objectives include advancing AI algorithms, expanding the exercise database, and fostering strategic partnerships to drive market adoption and scalability. KEMTAI's team of experts in physiotherapy, motion capture technology, AI, UX/UI, and programming brings extensive experience and a strong track record of innovation. Kematai's current product for home phisiotherapy has over 10,000 costemers. This expertise ensures the successful development and implementation of KEMTAI-DDX. KEMTAI-DDX is poised to become highly profitable, with projected sales growth from €500k in 2027 to €40 million in 2030. The scalable nature of the platform positions KEMTAI-DDX as a key player in the digital health market, promising transformative benefits for patients, healthcare providers, and the broader healthcare ecosystem.

Keywords: digital health,musculoskeletal disorders,remote healthcare,home based traige,ai driven diagnosis
Multi-component interventions to reducing unhealthy diets and physical inactivity among adolescents in sub-Saharan Africa (Generation-H)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Belgium,Ghana,Kenya,Netherlands,United Kingdom
Call: Non-communicable diseases risk reduction in adolescence and youth (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2685625.0
EU funding (EUR): 2685625.0
Participants: 8
Project status: SIGNED

The fragile health systems in urban sub-Saharan Africa (SSA) are already overwhelmed with NCDs. Despite this, the implementation of the evidence-based WHO Best Buys policies for NCDs prevention in the African region has been found to be off-track. Additionally, less attention has been given to adolescents and yet this is a period in life where behavioural patterns of NCDs risk factors are established and track into adulthood. There is also a gap in our understanding on how to implement and scale up effective diet and physical activity interventions in real world settings in SSA. Our project therefore aims to reduce two important modifiable risk factors for NCDs: unhealthy diets and physical inactivity and their underlying social determinants among adolescents (aged 10-19 years) living in mixed socio-economic urban communities in two SSA countries (Ghana & Kenya) by designing, deploying, and evaluating strategies for implementation of evidenced and theory based interventions mapped on to the WHO Best Buys. We selected the two countries because they represent different cultural contexts of nutrition transition (East and West Africa), and both countries are undergoing rapid economic development, urbanisation and increases in NCD prevalence. The intervention delivery will take a multi-sectoral approach to increasing the capability, opportunity and motivation of adolescents to eat healthier and be more physically active. We will focus on three settings to enhance the reach: secondary schools and, family/community/faith-based settings and the digital environment using social media. Together, this project will increase opportunities, awareness, knowledge and health literacy, motivate adolescents to increase self-efficacy, guide self-regulatory actions and adopt positive health behaviour (such as dissuasion from physical inactivity and sedentary behaviours, or unhealthy food choices) to prevent NCDs.

Keywords: implementation science ncds behaviour risk factors who best buys adolescents and youth sub saharan africa
Synaptic engrams in hippocampal CA3 memory circuits (CA3-SYNGRAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

A fundamental question in neuroscience is how information in brain circuits is stored and retrieved. However, the physical and chemical changes underlying the formation of memories, or “engrams”, are largely elusive. Although recent work identified engram cells, the nanoscopic changes at synapses during engram formation remain unclear. New experimental techniques allow us to probe the subcellular and synaptic components of the engram: functional analysis by multicellular electrophysiology, structural analysis by superresolution light and electron microscopy, and optical recording and stimulation techniques in vivo. Here, we propose to combine these techniques to reveal engrams in the hippocampal CA3 network. This circuit is ideally suited to identify engrams, as it plays a critical role in learning and memory, forms the largest recurrent network throughout the brain, and receives powerful input from hippocampal granule cells, previously defined as engram cells. The project has two main goals. First, we want to identify the physical and chemical changes in the CA3 network during engram formation, especially changes in synaptic transmission and network connectivity. Thus, we will be able to rigorously test cellular, synaptic, and connectomic hypotheses of the engram. Second, we want to probe the rules of synaptic engram storage (“engraphy“), the mechanisms of engram retrieval (“ecphory“), and the behavioral content of the engrams. Hence, we will be able to enrich the classical engram concept with quantitative data on how synaptic engrams are efficiently stored and reliably retrieved. Taken together, the expected results will lead to a substantial increase in our understanding of engrams, advancing it from the cellular to the synaptic level. The proposed experiments will answer a fundamental question in neuroscience and open new avenues for treatment of brain diseases in humans, in which engram formation or retrieval are impaired.

Keywords: glutamatergic synapses,presynaptic terminals,hippocampus,ca3 region,synaptic plasticity,functional connectivity,learning and memory
Targeting intracelular RANKL in breast cancer (Intra-RANKL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Breast cancer is the most common malignancy among females in the western world, resulting in half a million deaths annually, mainly due to metastatic disease. Triple negative breast cancer (TNBC) accounts for 15–20% of all breast cancers (300.000 women diagnosed worldwide per year). Despite novel treatments, TNBC remains a clinical challenge due to high rate of relapse, a propensity to form visceral metastasis and its heterogeneity. There is an urgent need to identify novel targeted therapies and associated biomarkers for the treatment of the TNBC. IntraRANKL is based on the generation of innovative drugs targeting RANKL – for the treatment of TNBC, with a different mechanism of action than denosumab, the gold standard treatment against RANKL. Small molecule inhibitors generated in IntraRANKL could plausibly be positioned as a novel targeted therapy for TNBC. The main benefits of IntraRANKL are based on the unmet need to improve the treatment of TNBC patients, and the economic burden for public health systems generated by standard non-selected and ineffective cancer treatments. Although our drugs are aimed for TNBC, they can benefit other breast cancer subtypes and tumors expressing RANKL. Moreover, if drugs against RANKL prove to be efficient, they could also clinically benefit patients suffering bone metastasis that are currently treated with denosumab and bisphosphonates. Analyses of RANKL will allow to stratify patients that might benefit from IntraRANKL inhibitors, improving the existing treatments for skeletal-related events and reducing the main complications associated with lifealtering morbidity affecting several types of prevalent cancers.

Keywords: intracellular rankl,triple negative breast cancer,rank signaling pathways,small molecules
A Metabolic Theory of Microbial Ecology (MetaMicro)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2757847.0
EU funding (EUR): 2757847.0
Participants: 1
Project status: SIGNED

Theoretical ecology has genuine potential to revolutionise microbiology, and vice versa. However, current models, such as the Lotka-Volterra equations, are typically too simplistic to apply and test rigorously. Critically, these models fail to capture microbial metabolism, which my lab and others have found central to predicting the ecology of diverse communities. My goal, therefore, is to develop a new theory of microbial ecology, rooted in metabolism, and to rigorously test it. We will capture nutrient competition, cross-feeding, interference competition and phage, and build our framework using methods from statistical mechanics. Throughout, we will experimentally test our theory using the gut microbiota as a model system. We will address three fundamental questions: 1: What determines the composition and stability of communities? Theory will be parameterised with large-scale culturing on defined media, metabolomics and whole-genome metabolic models. We will empirically test our ability to predict composition and ecological stability, and to understand the diversity-stability relationship. 2: What determines ecological success? We will study what makes a strain successful within a community, incorporating metabolism, bacterial warfare, and phage predation. 3: How does the host environment shape microbial ecology? We will employ agent-based simulations to capture spatial structure and test them with a new in-vitro organoid model of the human gut mucosa and our new in-vivo imaging pipeline for mouse microbiomes. Our plans have risk because ecological systems are complex and hard to understand. However, our work promises to deliver a step-change in both ecology and microbiology by making the study of microbial communities a predictive science, where one can understand ahead-of-time how particular sets of species will behave as a system. Furthermore, we will help establish the ecological principles needed to rationally manipulate our own microbiomes.

Keywords: ecology,human microbiome,theoretical ecology
Economic, Social and Spatial Inequalities in Europe in the Era of Global Mega-trends (ESSPIN) (ESSPIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Greece,Germany,Poland,Italy,Romania,Finland,Czechia,Ireland,France,Netherlands,United Kingdom
Call: Determining key drivers of inequality trends (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2674000.0
EU funding (EUR): 2674000.0
Participants: 13
Project status: SIGNED

The goal of this research proposal is to re-examine the nexus of social, economic and spatial inequalities in the EU, the various typologies and the arrangements and mix of policies addressing them, in the light of emerging and highly interacting mega-trends and challenges, threatening to increase pressures and make policy choices even more difficult. As new and older drivers of change are projected to create a rather unfavorable environment for balanced growth and socio-spatial resilience, this research will focus on the analysis of policy responses, aiming to make them more pro-active, inclusive and effective. The novel contribution of the proposed research project lies on a holistic and integrated approach that relates in an interactive way drivers to outcomes and levels of aggregation. The aim is to detect, model and map the interdependence among drivers of inequality and outcomes (including circular causality) in a multi-level, poly parametric context with specific tailor-made policy recommendations.

Keywords: inequalities,economic geography,social change,technological evolution,mega trends,social and regional policies
rEVealIng Drug Effects when applyiNg psychomeTrics In schizophreniA triaLs (EVIDENTIAL) (EVIDENTIAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2026-09-30
Duration (months): 12.0
Total project cost (EUR): 134284.32
EU funding (EUR): 134284.32
Participants: 1
Project status: SIGNED

The EVIDENTIAL project (rEVealIng Drug Effects when applyiNg psychomeTrics In schizophreniA triaLs) seeks to enhance the accuracy of treatment outcome measurements in schizophrenia clinical trials by refining existing gold standard assessment tools such as the Positive and Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS). These tools have limitations in accurately measuring treatment efficacy. The project aims to address this by applying advanced psychometric methods, including Factor Analysis (FA), Item Response Theory (IRT), and Network Analysis (NA), to reduce measurement errors and improve the detection of treatment effects, potentially resulting in larger effect sizes. Objectives include analyzing the psychometric properties of PANSS and BPRS using FA, IRT, and NA to reduce error and improve symptom assessment accuracy, and investigating whether these improved models yield larger effect sizes in clinical trials. These efforts align with the EU’s focus on better mental health outcomes through enhanced treatment strategies. The project is structured into two key work packages: WP1: Focuses on psychometric evaluation of PANSS and BPRS using data from multiple randomized clinical trials, aiming to refine these tools and explore symptom differences across gender and ethnicity. WP2: Applies the refined models to existing trial data, comparing traditional and psychometrically-informed effect sizes to assess improvements. The skills gained through this fellowship will equip me to become a leading expert in psychometric applications for psychiatric disorders, particularly schizophrenia. The combination of research and training will prepare me for a future role as a principal investigator/research director, allowing me to lead innovative projects that advance the field of mental health research. Ultimately, EVIDENTIAL could significantly improve clinical decision-making and the effectiveness of schizophrenia treatments.

Keywords: schizophrenia,psychometrics,randomised trials,effect sizes,statistics
High Arctic Ocean Observation System (HiAOOS)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Norway,Poland,Germany,United Kingdom,Greece,Netherlands
Call: R&D for the next generation of scientific instrumentation, tools and methods (HORIZON-INFRA-2022-TECH-01, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 9500358.51
EU funding (EUR): 9500358.51
Participants: 13
Project status: SIGNED

HiAOOS will develop, implement, and validate several ocean observing technologies to improve data collection in the ice-covered Arctic Ocean. A network of multipurpose moorings will be deployed for two years in the deep Nansen and Amundsen Basins. The network will provide point measurements of ocean and sea ice and active and passive acoustic data for several applications, including acoustic thermometry, geo-positioning of underwater floats, detection of marine mammals, geohazards and human generate noise. The mooring system will build on the successful basin wide Coordinated Arctic Acoustic Thermometry Experiment-CAATEX experiment and extend the existing Mooring Observations from the Atlantic Water Inflow Experiment (ATWAIN). A new generation of moorings will be developed where data can be transferred to the surface using ROV or winch technology. Ice buoys with new acoustic array technology will be developed for testing of underwater geo-positioning, local navigation networks for glider operations and for localization of geophysical events. These developments will advance several research infra structures with new observing technology and create new opportunities for forefront research. To unlock the capabilities of the new observing system methods and tools will be developed to analyse and visualize the observations for different applications using digital methods and technologies including machine learning. The methods and tools will be ingested into a digital platform blue Insight, and available through Zenodo. Training and use cases will use the platform to train different user groups associated with research infrastructures, research communities and technology developers. All data, methods and tools will be available following the FAIR principles. Field experiments will be carried out every summer from 2024 to 2026, and every field experiment will be assessed with respect to environemntal impact prior to the start of the experiment.

Keywords: multipurpose mooring network,underwater positioning,acoustic thermometry,ocean observations in near real time,central arctic ocean,digital platforms