Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development, optimisation and implementation of artificial intelligence methods for real world data analyses in regulatory decision-making and health technology assessment along the product lifecycle (Real4Reg)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Germany,Finland,Portugal,Denmark,Belgium,Ireland
Call: New methods for the effective use of real-world data and/or synthetic data in regulatory decision-making and/or in health technology assessment (HORIZON-HLTH-2022-TOOL-11, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 6999425.0
EU funding (EUR): 6999425.0
Participants: 10
Project status: SIGNED

Real-world evidence derived from real-world data (RWD) has a promising role to inform regulatory decision-making. Based on highly relevant use cases from regulatory practice and across the product lifecycle Real4Reg develops AI-based data-driven methods and tools for the assessment of medicinal products. Findings will inform training activities on good practice examples and will be implemented in existing and emerging guidelines for both health regulatory authorities and health technology assessment (HTA) bodies across Europe. There is urgent need to enable the use and establish the value of the application of RWD across the spectrum of regulatory use cases. The use of RWD is established in regulatory processes such as safety monitoring, but evidentiary value for further use cases, especially in the pre-authorisation and evaluation phase of medicinal products, is rudimentary. The use of RWD in post-authorisation steps is constrained by data variability and by challenges in analysing data from different settings and sources. Thus, the development of new and optimised methods for RWD analyses is essential. Real4Reg addresses the challenges and opportunities of RWD analyses across different health care systems by involving multiple stakeholders to work together in a collaborative approach, also outreaching to already established European initiatives. Our consortium assembles partners with outstanding excellence in the field of RWD analyses, including experts from regulatory agencies/ HTA (BfArM, DKMA, Infarmed), academia (Fraunhofer, UEF, CSC, AU) and patient organisations (EUpALS, EIWH). In an advisory board stakeholders provide input and guidance to the project, including patients, industry, payers, HTA bodies and healthcare professionals. The structure and approach of our project facilitates the successful implementation of the effective use of RWD in regulatory decision-making and HTA, and ultimately supports the application of better medicines for patients.

Keywords: ai,digital twins,rwe implementation in regulatory decision making hta,pharmacoepidemiology
Carbon Neutral European Battery Cell Production with Sustainable, Innovative Processes and 3D Electrode Design to Manufacture (BatWoMan)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Austria,Spain,Germany,Italy,Sweden,Greece
Call: Environmentally sustainable processing techniques applied to large scale electrode and cell component manufacturing for Li ion batteries (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 5170563.0
EU funding (EUR): 5170563.0
Participants: 8
Project status: SIGNED

BatWoMan develops new sustainable and cost-efficient Li-ion battery cell production concepts, paving the way towards carbon neutral cell production within the European Union. This is realized via the following technological efforts: 1) energy-efficient, no volatile organic compounds (VOCs) processed electrodes, with slurries of high dry mass content; 2) innovative dry room reducing concept with improved electrolyte filling; 3) low-cost and energy-efficient cell conditioning, namely wetting, formation and ageing. The above stated technological improvements will be supported digitally via creating an AI-driven, innovative platform for smart re-tooling, constantly monitoring the sustainability and efficiency of the proposed individual production steps and developing a battery data space providing relevant cell background data. This way, BatWoMan will lead to estimated cell production cost reduction of 63.5% and cell production energy consumption reduction by 52.6% and therefore enable a European leadership position in sustainable battery production.

Keywords: battery cell production sustainable processing 3d electrode design solvent free
Materials, Objects and People: The Mould-Made Terra Sigillata from the Arretine Production of Cn. Ateius (Arretino modo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

The present research aims to analyse the production process of the mould-made terra sigillata produced by Cn. Ateius’ atelier (20/15-5 BC). A well-known dump found in the 1950s of the Twentieth Century in Via Nardi (Arezzo, IT) referred to this atelier will be the case study. The study of this archaeological context is a unique opportunity to learn about the dynamics of the mould-made terra sigillata production. The first step will focus on the morphological and typological study of vessels, bowl-moulds and spacers referable to this atelier. The fragments will be digitised with a 3D scanner and analysed by AI in order to collect all the stamped motifs, reconstruct the decorative registers and find the traces left by the craftsmen during the production process. Thanks to these actions we will be able to define the shapes and decorations of the mould-made artefacts from the workshop of Cn. Ateius, whose production remains almost entirely unpublished. In order to explore the production process, the mineralogical-petrographic and chemical composition of ceramics, 120 samples will be analysed as follows: X-ray diffractometry (XRD), X-ray fluorescence (XRF), electron microscopy (SEM) and polarised light microscopy. In addition, the dynamics of exploitation and depletion of natural resources in Roman times will be studied by sampling and analysing the clay deposits in the plain between Arezzo and Cincelli. Finally, all the marks left by the artisans during the production process will be studied. The study of stamps, graffiti and fingerprints will, in fact, provide information on the names, gender and age of the workers. In conclusion, the research will add new data on the various aspects of Aretine pottery production process and thanks to its interdisciplinary approach will also shed light on the individuals who made these artefacts.

Keywords: mould made terra sigillata,pottery workshops,archaeometric analyses,stamps,graffiti,workers
Defining the Mechanisms of gp78 as a Master Regulator of Ubiquitin E3 Ligase in Membrane Protein Quality Control. (gp78-MPQC hub)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

The ubiquitin-proteasome system (UPS) is responsible for the degradation of approximately 80% of proteins, enabling precise control of protein quality and maintaining protein homeostasis within the cell. Over the past four decades, a comprehensive understanding of the regulatory mechanisms governing the UPS, particularly concerning various cytosolic and nuclear proteins has been developed. However, there remains significant knowledge gaps regarding how membrane proteins, which account for one-third of human proteins and serve as targets for 70% of FDA-approved drugs, are regulated by the UPS. The specificity of the UPS is dictated by E3 ligases, which bind to substrates and execute ubiquitination. gp78 is the master regulatory ubiquitin E3 ligase for membrane proteins, enabling rigorous control of membrane protein quality and participating in various pathways. gp78 not only works with the biogenesis factors to form a detection center responsible for targeting misfolded proteins but also cooperates with the E2 enzyme and several quality control factors to promote recognition and ubiquitination of a wide range of important substrates, leading to their degradation via the proteasome. Yet remaining questions abound: How does gp78 detect misfolded proteins? What are gp78's substrates and their biological functions? What structural mechanisms underlie the recognition and ubiquitination of membrane substrates by gp78? This proposal aims to combine state-of-the-art approaches in structural biology and biochemistry, cell biology, and chemical biology to systematically dissect the underlying molecular mechanisms by which the gp78 membrane protein quality control hub, mediates substrate detection, recognition, and ubiquitination. The project will advance our understanding of how cells perform the difficult task of membrane protein quality control and pave the way for pharmacological studies targeting membrane protein degradation.

Keywords: ubiquitin,e3 ligase,membrane protein quality control,ups,emc
A Theory of Memory Causation (MEMOCAUSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

On the causal theory of memory, remembering an event requires a causal connection to a past experience. I can remember my last birthday because I have experienced it before. On the simulation theory, in contrast, remembering a past event is very much like imagining a future one: in both cases, a causal connection to a first-hand experience of the event is not necessary. The debate between causalists and simulationists has been at center stage in the thriving new field of philosophy of memory. Despite this, there has been no systematic analysis of the notion of causation relevant to memory. As a result, the nature of memory causation has remained largely unexplored. This project aims to fill this significant lacuna. It will develop the first comprehensive theory of memory causation, bringing together results from the philosophy of causation and the interdisciplinary study of memory. It will aim to clarify what it means to say that memories are caused by past experiences and to establish whether such causation is necessary. The project's core thesis is that claims about memory causation should be relativized to causal models — mathematical models that represent the functional relationships between variables in a system. A memory is caused by a past experience iff, relative to an appropriate model of the memory system, it is counterfactually dependent on it, but only in precisely defined contexts. If all memories are so dependent, then causation is necessary for remembering. With a proper formulation, the causal necessity thesis can be assessed. The working hypothesis is that the thesis faces substantial difficulties and is likely false. Hence, causal theories fail and the simulationist rejection of the necessity of appropriate causation is warranted. The project will make an innovative and much-needed contribution to the central debate of contemporary philosophy of memory, helping us understand what memory is.

Keywords: philosophy of memory causal theory of memory simulation theory of memory causation causal models memory traces
Making time-resolved cryo-EM available for the community of structural biologists: validate, improve, derisk (trEM4all)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-02-01
End date: 2025-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Knowledge of protein structure is fundamental for the understanding of biology, disease mechanisms, drug development, and biotechnology. Recent progress with electron cryogenic microscopy (cryo-EM) simplified and tremendously accelerated the determination of protein structures including multiple protein conformations. Many functionally important protein conformations and protein-protein complexes are transient and are not easily accessible by conventional cryo-EM. These transient states can, however, be freeze-trapped and their structures solved to high resolution using the time-resolved cryo-EM (trEM). Despite its long history and high interest from the cryo-EM community, technical difficulties prevented the spread of the methodology, and no commercial devices enabling trEM sample preparation exists. During the ERC-CoG project, we developed a new approach to the preparation of trEM samples which has advantages over the other reported technologies. In this POC project, we propose to undertake steps that will explore the suitability of our technology for application to a wide variety of protein samples and to evaluate the commercial potential of the technology with aim of bringing it to cryo-EM users rapidly. To achieve this, we plan to (1) expand the number of protein samples to be tested on our instrument thus enabling rapid user access and simultaneous validation of the methodology, (2) perform additional research to further improve the method by addressing the remaining bottlenecks, (3) make steps towards defining the best process and materials for industrial production of microfluidic chips, and (4) redesign the time-resolved plunger into a compact pre-industrial prototype. These steps will broadly validate, improve, and derisk the technology to make it more attractive to cryo-EM instrumentation-making companies to bring the technology to the cryo-EM community.
Deciphering signalling pathway dynamics during cell-fate commitment in stem cells (i-SignalTrace)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Understanding the identity and intensity of the specific extracellular signals that a cell experiences at different times during its differentiation is essential to develop advanced cellular therapies. However, uncovering the sequence of these signaling events, their intensities, timing, and relevance in development and disease is proving to be very challenging. Here, I propose to build i-SignalTrace: a CRISPR/Cas9-based molecular recorder with the capacity to store both lineage information and signalling pathway activity for multiple signals over time in single cells. By performing kinetic experiments and mathematical modeling, I will use i-SignalTrace to extract the probability of signalling pathways to be activated in stem cells when subject to different extracellular signals and reconstruct the lineage tree of pathway activities during differentiation with single-cell resolution. In combination with single-cell RNA sequencing, i-SignalTrace will make it possible to characterize transition and intermediate states along differentiation trajectories, and quantify the integration between extracellular signals and autonomous programs of gene expression. These results will allow predicting the differentiation trajectories that stem cells follow when subject to external perturbations, and deciphering the role of heterogeneity in signalling pathway activity during cell-fate commitment. Using i-SignalTrace, I will identify missing or redundant signalling pathways induced during in vitro differentiation protocols. Therefore, I expect that exploitation of i-SignalTrace will allow establishing new criteria to design protocols to differentiate stem cells on demand. As a proof-of-concept, I propose a framework to improve the functionality of monolayer-derived cardiomyocytes. Taken together, i- SignalTrace will find applications in both fundamental developmental biology and translational regenerative medicine, which will benefit a much wider scientific community.

Keywords: crispr cas9 based lineage tracing,single cell sequencing,waddington landscape,in vitro differentiation,differentiation trajectory,cell differentiation
Nanorobotic microgels to control stem cell fate (uStemGel)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Myocardial infarction continues to claim the lives of millions of people every year, and survivors are often left with severe health issues. Transplanting cardiac cells engineered from human stem cells into the injured heart is a particularly promising approach to repairing damaged cardiac tissue. Despite extensive research on stem cell-based therapies, a major limitation is effectively regulating stem cell differentiation. Mechanically training stem cells throughout culture could be solution, by exploiting their mechanosensitive nature. However, there is currently a lack of technology that can recreate the mechanically dynamic microenvironment of tissue. Therefore, I aim to develop an innovative cell culture technology, based on designer microgels and nanorobotics, which will allow control over stem cell differentiation. To achieve this goal, I will package pluripotent stem cells in smart microgels using microfluidics. By rigorously adjusting material properties, I will ensure culture conditions that simulate the native tissue microenvironment. The smart microgels will have tunable stiffness, which I will use to improve cardiogenic differentiation in pluripotent stem cells. I will integrate wirelessly controlled nanoactuators to mechanically train stem cells to decipher the relationship between forces and stem cell differentiation. Together with my team, I will develop rapid culture and stimulation methods based on microfluidics to identify the best conditions for stem cell preparation. This multifunctional technology will contribute to achieving efficient cardiac regeneration, and has great potential to make a big impact in regenerative medicine.

Keywords: nanorobotics,soft microrobotic systems,stem cells,mechanobiology,microfluidics,active biomaterials
The Musical Avant-garde in Rome in the 1960s: Actors and Networks in Music History (ROMAVANTGARDE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: CLOSED

ROMAVANTGARDE aims to reveal a particular phenomenon in the history of music: the effervescence of avant-garde networks in Rome during the 1960s. This phenomenon saw the first steps of influential figures to come: Frederic Rzewski, Alvin Curran, and Ennio Morricone. But it is also of particular interest as it involved a large number of artists from varied national and cultural horizons, connected diverse institutions (schools, bars, religious establishments), and saw the encounter of various genres (art music, jazz, and popular music) to create original repertoires. As a consequence, this is an ideal case to show how art music creation—despite the enduring paradigm of the individual genius—is a collective phenomenon involving human, but also nonhuman actors (institutions, artifacts, ideas). To do so, ROMAVANTGARDE will draw specifically on Actor-Network Theory (ANT), but also on Social Network Analysis (SNA). Through this case study, ROMAVANTGARDE aims to advance knowledge on the history of twentieth-century music and to reveal Rome as a cosmopolitan city actively participating in the construction of the European musical landscape. At the same time, It aims to further research on creativity and to encourage the recent exchanges between network theories and music studies. This project will be undertaken in Sapienza University of Rome, a reputed university for research in the history of music. Sapienza is also the ideal institution to carry out research in the city’s libraries and archives and to carry out the collection of testimonies before witnesses disappear. Professor Emanuele Senici, an internationally renowned music historian with extensive experience in the history of modern and Roman music, will supervise this project. This experience is thus expected to have a profound impact on my training, scientific maturity, and reputation and to place me in good stead to qualify for a tenure-track position in Europe.

Keywords: music,20th century music,avant garde,rome,italy,history of music,musicology,actor network theory,digital humanities