Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Surpassing traditional strength limits by additive Manufacturing of innovative alloys (STAMINA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: SIGNED

High-strength materials play a pivotal role in materials engineering, offering exceptional durability, mechanical reliability, and an enhanced strength-to-weight ratio. As a result, they are in high demand across various industries, including automotive, aerospace, and construction, where they contribute to improved safety, sustainability, fuel efficiency, and maintenance costs. However, the development of ultrahigh strength alloys has been impeded by challenges such as the strength-ductility trade-off and microstructural control. To overcome these limitations, the "STAMINA" project aims to harness the potential of immiscible alloys combined with rapid solidification through laser powder bed fusion (LPBF) - an Additive Manufacturing (AM) method- to fabricate alloys with unprecedented strength (>2-5 GPa). The innovative combination of Fe-Cu immiscible alloys and LPBF results in a unique microstructure characterised by fine grains and nano-sized, nano-spaced precipitates formed during the rapid solidification of two immiscible phases. However, the printing of immiscible alloys faces obstacles, notably liquation cracking during LPBF. To address these challenges, the STAMINA project focuses on optimising laser parameters and alloy composition to achieve a defect-free microstructure with a uniform distribution of nano (2-5 nm) precipitates and ultrafine grains, with the latter leading to isotropic mechanical properties. Additionally, the project pioneers the study of two liquid interactions under severe convection using high-energy X-ray analysis. By integrating expertise from multiple disciplines, including materials engineering, AM, and fluid dynamics, STAMINA seeks to establish theoretical foundations and innovative techniques for producing novel immiscible alloys. The successful realisation of this research has the potential to unlock new frontiers for cutting-edge technologies, which are currently limited by the availability of high-strength materials.

Keywords: ultrahigh strength immisicble alloys dispersion strengthening additive manufacturing melt pool dynamics grain refinement
Mitochondria-ER communication by contact sites during plant stress responses (INTERCOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: CLOSED

It is common knowledge that an ethernet connection is safer than a wireless connection, and cellular organelles share this approach. To communicate directly among each other, organelles are thought to use Membrane Contact Sites (MCS), the “optical fibers” at the intracellular level. Organelles are in a prime position to sense and communicate stress signals due to their tight integration into the cell’s metabolic networks. Inter-organelle communication is thus crucial to pass on the message to coordinate cellular stress responses and maintain homeostasis. I hypothesise that MCS allow fast and efficient communication of stress signals between intracellular organelles (e.g. mitochondria and ER) to coordinate the cellular stress responses. However, the organelle tethering proteins, the stimuli driving MCS formation and the signalling molecules mediated through these MCS remain elusive in plants. In INTERCOM, I will characterise ER-mitochondria communication in response to stress in Arabidopsis thaliana. For that, I will leverage the host lab’s previously established ER-mitochondria communication model system and establish a proteomic screening setup to identify novel proteins involved in ER-mitochondria MCS in plants. In addition, I will develop a high-throughput platform to study inter-organelle interactions in vivo and to identify stimuli driving MCS dynamics. Finally, I will employ genetically encoded biosensors to pinpoint ROS and calcium inter-organelle signalling events. To reach my goal, I will combine my expertise in intracellular signalling and bioimaging with cutting-edge interactomics, live-cell imaging and high-content technologies available at the host institute. This innovative and interdisciplinary approach will allow me to shed light on plant inter-organelle communication, a field still in its infancy in plant biology with the potential to pave the path for the biotechnological engineering of plants more resilient to harmful environmental conditions.

Keywords: inter organelle communication plant membrane contact sites endoplasmic reticulum mitochondria protein protein interactions plant stress response
Adaptive Risk Cultural Heritage Assessment In Conservation (ARCHAIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

The current project, ARCHAIC (Adaptive Risk Cultural Heritage Assessment In Conservation), aims to provide a new intelligent method for the risk management of heritages. In ARCHAIC, I plan to recognize physical deterioration and degradation evolution in monuments by computer vision methods (using a combination of Neural Radiance Fields (NeRF) and social media imagery) and use them as inputs to assess the degree of vulnerability via the neuro-fuzzy method. To compare social media photos captured at various times for detecting changes, deterioration, and achieving deterioration growth, I encounter the challenge that the images vary in camera. By reconstructing 3D models of monuments at various times via NeRF and comparing images, we can effectively identify changes and deterioration over time. Camera pose estimation is performed using Inerf, a deep neural network-based method specifically designed for accurate camera pose estimation of social media images. The estimated poses are utilized and given to the NeRF models to generate pair comparison viewpoints for image analysis. Finally, I consider detected deterioration’s type, boundary, amount, and growth for the fuzzy rules. ARCHAIC leads to determining the amount of intervention to manage the risks of a query case of a monument.

Keywords: cultural heritage,artificial intelligence,conservation,risk assessment
Laser bioprinting device and in vivo applications (Laser bioprinting device and in vivo applications)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Greece
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 2857943.38
EU funding (EUR): 2000560.0
Participants: 1
Project status: SIGNED

PhosPrint's D-LIB platform technology is based on a compact and automated laser bioprinter and protocols for high-speed and high-precision in-vivo printing of tissues with autologous human body characteristics. The bioprinter relies on the Laser Induced Forward Transfer (LIFT) technique to accomplish highly accurate and cost-effective printing of tissues. The bioprinter system is associated with protocols for cell isolation from autologous biopsies, cell expansion in-vitro, and cell printing in-vivo. This is a truly new approach that allows for real-time tissue engineering/repair in complex medical conditions. D-LIB capabilities will enable the introduction of a laser bioprinting technology in surgery operations, starting with enterocystoplasty/augmentation in cystectomy bladder cancer patients as the selected go-to-market application.

Keywords: tissue regeneration,laser bioprinting
Twinning for excellence in Smart and Resilient Urban Development: Advanced Data Analytics Approach (UR-DATA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,Italy,Norway
Call: Twinning Western Balkans Special (HORIZON-WIDERA-2021-ACCESS-02, 2021)
Start date: 2022-07-01
End date: 2025-07-31
Duration (months): 37.0
Total project cost (EUR): 1435900.0
EU funding (EUR): 1435900.0
Participants: 3
Project status: SIGNED

The project aims to strengthen significantly the research capacity and scientific excellence at the Faculty of Economics, University of Niš (FEUN) by enhancing networking activities with Poliedra - Polytechnic University of Milan (POLIEDRA) and Oslo Metropolitan University (OSLOMET) in the field of smart and resilient urban and regional development using state-of-the-art data analytics and optimization tools in a data-rich environment. This is to be achieved through the following objectives: - Enhancing the scientific capacity of FEUN by establishing a Laboratory of Land Economy and Urban Analytics (LEUA) at FEUN where the researchers from POLIEDRA and OSLOMET will perform training activities, transfer knowledge and best practices, conduct workshops and seminars aimed to include early-stage researchers and FEUN staff; - Raising the research profile of FEUN staff through strengthening research experience and collaborative research and joint papers with researchers from leading European universities - Creating a long-term scientific strategy of FEUN for stepping up and stimulating scientific excellence in the field of smart and resilient urban development analysis using contemporary quantitative tools of data analytics - Enhancing career prospects for early-stage researchers, through short-term exchanges, workshops, seminars and summer schools, with renowned researchers in the field -Strengthening administrative and project management skills of staff at FEUN, by establishing Project Management unit to deal exclusively with the preparation of project proposals, administration and financial management of projects. The project addresses the specific challenge of enhancing networking activities between a research institution from the widening country and two internationally leading European counterparts. By strengthening the research management and administrative skills of the coordination institution from the WB country, the project will help raise its research profile.

Keywords: knowledge transfer,exchange of best practice in sustainable and resilient urban development research,scientific excellence in urban analysis
Heavy and Extractive industry wastes PHAsing out through ESG Tailings Upcycling Synergy (HEPHAESTUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Countries involved: Italy,Greece,Belgium
Call: Reducing environmental footprint, improving circularity in extractive and processing value chains (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2026-11-30
Duration (months): 54.0
Total project cost (EUR): 16046783.75
EU funding (EUR): 11966323.0
Participants: 10
Project status: SIGNED

The HEPHAESTUS project is built around one key, overarching objective: To develop a set of scalable and tuneable unit operations, to be built as integrated processing plant, featuring the capacity to treat multiple process wastes deriving from primary mineral and metallurgical (primary and secondary) streams. The unit operations are: - Clean-Tech electric furnace, to transform the EAF and AOD dust into metal alloy to be immediately remelted, process supported with streams of fines by-products from the mineral primary extractions (construction, aggregates and dimensional stone) - EZINEX process, to extract the zinc present in the dust of the furnace - Fibre drawing, for mineral wool manufacturing out of the process slag in molten state - Catalytic conversion of CO2 gas into methanol or formic acid - Ammonia-ammonium carbonate (AAC) and methanesulfonic acid (MSA) based hydrometallurgical processes, to produce a recyclable Fe-rich residue and to recover metals (e.g.e.g., ZnS) from EAF dust The project is targeting primarily small-scale applications (order of magnitude 10 k tons waste dust per year), to cope with the typically fragmented European process size. Such scale is matching the waste volumes and differentiation and granting positive environmental AND economic sustainability through the valorisation of different streams of by-products at low operational and capital expenditure, ensuring vast replicability and short ROI Project will be demonstrated in two pilot applications, in Greece and Italy, with the purpose of creating awareness on the business potential and to generate the conditions for a long-term exploitation, leading to meaningful reduction of wastes for the extractive and steel industries.

Keywords: steel dust recycling recovery of mineral fine dust tailings process circular economy industrial synergy eaf and aod dust recycling mineral wool zinc carbon capture and transformation methanol
Samarium Diiodide Catalysis for Novel Bioiosteres (Sam-4-Bio)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

The concept of bioisosteric replacement of arene pharmacophores in drug candidates has garnered increasing attention as a powerful tool to circumvent the production of toxic metabolites through detrimental metabolic modifications of the arene backbone. Replacement of the arene core in drug candidates with rigid, C(sp3)-rich bioisosteric scaffold improves their metabolic stability, potency, lipophilicity, and solubility. Crucially, cage-like structures with defined exit vectors renders them bioisosteres with superior ability to dock in the chiral binding pocket of the target receptor. Therefore, the demand for C(sp3)-rich bioisosteric replacements is skyrocketing and recent endeavors have provided a variety of decorated saturated systems mimicking substituted arenes. While initial studies were mostly directed towards bioisosteres of mono- and para-substituted arenes, recent efforts have focussed more on bioisosteres for ortho- and meta-substituted aromatic rings. Despite the significant development of synthetic strategies for preparing already proven bioisosteres, the lack of synthetic methods to access many unexplored analogues, such as bicyclo[2.2.1]heptanes (BCHeps), renders their potential undetermined to date. Consequently, developing general, catalytic, sustainable methods for rapidly accessing 1,2-BCHeps is an urgent necessity. Recent breakthroughs from the Procter group have set a new benchmark by applying radical relay catalysis using SmI2 for accessing bioisosteric scaffolds. Sam-4-Bio will integrate this novel concept with the group’s recent finding of enhancing catalytic efficiency of SmI2 by photoactivation, to develop a catalytic platform for accessing unexplored bioisosteres of ortho-arenes like 1,2-BCHeps. Challenging insertion of alkene into the bridgehead bond of strained housane ketones under SmI2-catalysis will deliver key intermediates for downstream manipulation en route to new saturated analogues of validated drugs with superior bioactivity.

Keywords: radical catalysis,samarium,bioisosteres
Mapping the Reception and Legacy of the Vikings in Europe (NorseMap)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1999519.0
EU funding (EUR): 1999519.0
Participants: 1
Project status: SIGNED

The modern understanding of the Vikings has developed over a thousand years to reflect the politics, identities and cultural memories of very different communities across Europe. This shared history impacts on many aspects of contemporary society and is appropriated in increasingly diverse ways. NorseMap posits that the oversignification of the Viking past can be approached as an ecology of interactions within which ideas of European culture and identity are made and remade. While this working hypothesis is based on observation of the current reception landscape, it is difficult to test because of a lack of data on public perceptions of the Vikings and the limitations of reception studies as currently conceived to map such a complex legacy. The guiding question that NorseMap asks – how is the Viking past used today, and how has public understanding of the Vikings evolved over time? – thus poses profound challenges for the discipline at both an applied and conceptual level. The applied challenge is how we capture widely dispersed data on uses of the Viking past in the present day. The conceptual challenge involves rethinking reception studies so it can address historical legacy at a macro level and account for the complexities of the reception ecosystem. NorseMap will make a step change in cultural heritage crowdsourcing, taking the model of app-based GIS mapping used for large-scale citizen science documentation projects and adapting it to the humanities. Reorienting the discipline to map the Viking legacy will entail drawing together various strands of reception history – Literature & Art; Branding & Tourism; Politics & Identity – and demonstrating how they have interacted to create a uniquely pliable cultural memory, using a conceptual lens inspired by Actor-Network Theory. The resulting Deep Map of reception will reveal the multiple influences that intersect in any individual reimagining of the Vikings and open up new ways of thinking about the remediated past.

Keywords: old norse viking studies reception cultural heritage crowdsourcing community engagement cultural legacies public history
Management, Orchestration and Supervision of AI-agent COmmunities for reliable AI in software engineering (MOSAICO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: France,Luxembourg,United Kingdom,Italy,Greece,Portugal,Israel,Germany,Ireland
Call: Fundamentals of Software Engineering (RIA) (HORIZON-CL4-2024-DIGITAL-EMERGING-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 6250730.36
EU funding (EUR): 5218186.88
Participants: 12
Project status: SIGNED

The reliable application of LLM-based agents to SE requires a tremendous increase in their accuracy and minimisation of their bias. While LLMs continue increasing in size and performance, it seems that phenomena like hallucinations of a single agent are substantially inevitable, since they are linked to the fundamental inference mechanism in generative models. On the other hand, evidence starts accumulating about the possibility of achieving the required performance by collaboration and debate among groups of agents. As it happens among humans, quality of work increases with specialisation of workers on tasks, organised collaboration, and discussion among workers with different backgrounds. Differently from humans, the instantiation of multiple required AI agents, and the collaboration and discussion among them, are very fast and cheap, making this approach particularly convenient. MOSAICO proposes the theoretical and technical framework to implement this approach and to scale it to very large groups of collaborating agents, i.e. AI-agent communities. The developed solutions are composed into an integrated MOSAICO platform, handling communication, orchestration, governance, quality assessment, benchmarking and reuse of AI agents. MOSAICO is integrated with existing development environments, to present the results to software engineers, and allow expert users to intervene in the AI decisions. The performance and reliability of MOSAICO technologies and tools to achieve given software engineering tasks are assessed within 4 different use cases scenarios coming from immersive technologies, bank/financing, aerospace and Internet of Things sectors. The long-term adoption of MOSAICO results and technologies will be ensured by open sourcing the code and fostering an open collaboration, such as open-source initiatives, to enhance user engagement in the MOSAICO community.

Keywords: artificial intelligence,ai assisted software engineering,responsible ai,generative ai,large language model,llm agent,multi agent system,integrated development environment,ai governance