Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Toward the comprehension of primary bioelectromagnetic interactions: real time non-linear OPTICal imaging of BIO-samples under ElectroMagnetic exposure (OPTIC BIOEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Cell membrane permeabilization, involving its reversible or irreversible restructuring, under extremely short electric (E) pulses exposure (from hundreds of us down to few ns) has a key role in a number of clinical, preclinical, and medical research applications. Hence, the knowledge of its bio-physical nature and dynamics (i.e. formation and resealing processes) is crucial for an aware control of delivered protocols, and for predicting treatments efficacy under established biological (e.g. buffer conductivity, cell dimensions) and electromagnetic (EM) conditions (e.g. pulse duration, amplitude, shape). To understand bio-physical mechanisms underlying such a pulse-exposure permeabilization, an innovative and advantageous approach is proposed based on real-time molecular vibrational modes imaging using fast Coherent anti-Stokes Raman Scattering (CARS) of in vitro samples under such a stimulation. Hence, in the present Marie Sklodowska Curie Action (MSCA), a fast CARS microscope will be integrated with a suitable wide band in vitro electromagnetic field (EMF) exposure setup to study the role of membrane lipid reactions and interfacial water in the electropermeabilization phenomenon. This innovative CARS analysis will be supported by mass spectroscopy measurements to verify the appearance of corresponding chemical species, and by simulated E field and pore density distributions on the bio-samples. This last step is an attempt to correlate sample areas presenting the highest CARS signal intensity with the correspondent E field and pore density distributions. The program that integrates engineering, physics, chemistry and biology will allow a substantial progression in my career and network ability through the work on a completely innovative, multidisciplinary and inter-disciplinary subject in one of the most reputed bioelectric laboratory, where the applications of electropermeabilization in biology and medicine where first developed in Europe and worldwide.

Keywords: cars spectroscopy,extremely short pulsed electric field,broad band electromagnetic exposure device,cell membrane electropermeabilization,lipid peroxidation,microfluidics
Sentinels Synergy for Agriculture (SENSAGRI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,Poland,France,France
Call: Evolution of Copernicus services (H2020-EO-2016, 2016)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 1854757.5
EU funding (EUR): 1854757.5
Participants: 7
Project status: CLOSED

In the emerging Copernicus Earth monitoring era, Europe provides Earth Observation (EO) data from Sentinel-1 (S1) and Sentinel-2 (S2) on a free and open data policy basis. In response of the EO Work programme ‘EO-3-2016: Evaluation of Copernicus Services’, Sentinels Synergy for Agriculture (SENSAGRI) aims to exploit the unprecedented capacity of S1 and S2 to develop an innovative portfolio of prototypes agricultural monitoring services. When used alone either optical or radar sensors allow the mapping of crop types. However more robust, accurate, frequently updated and comprehensive crop maps are expected from the seldom exploited synergy of both types of measurements. The same holds when dealing with crop status, health and stresses. Experimental studies have demonstrated that fusion of optical and radar data opens up prospects for enhanced monitoring capabilities. SENSAGRI will exploit the synergy of optical and radar measurements to develop three prototype services capable of near real time operations: (1) surface soil moisture (SSM), (2) green and brown leaf area index (LAI) and (3) crop type mapping. These prototypes shall provide a baseline for advanced services that can boost the competitiveness of the European agro-industrial sector. SENSAGRI proposes four advanced proof-of-concept services: (i) yield/biomass, (ii) tillage change, (iii) irrigation and (iv) advanced crop maps. The algorithms will be developed and validated in four European agricultural test areas in Spain, France, Italy and Poland, which are representative of the European crop diversity, and their usefulness demonstrated in at least two non-European countries. In order to refine the specifications of the products and to iteratively assess the services, actors of the agricultural sector will be involved using a Living Lab approach. The combination of user-centered approach and of state-of-the-art algorithms will establish a sound foundation for deciding of a new Copernicus land service.
Voltage Shield Stabilizer Regulator (SSR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The mission of Castoldi&Moretti (C&M) is to design, produce and commercialize devices for electrical grids’ control and in particular voltage stabilizers and other devices that have similar aims. The growing % of unstable and unpredictable renewable energy sources (RES) used for power production and the wider presence of distributed generation alters the current standards for electric grids and creates further disadvantages in terms of voltage fluctuations, and thus strengthens the demand of voltage stabilizers in industrialized and emerging countries. The innovative voltage stabilizer SSR-Shield Stabilizer Regulator can stabilize the voltage level at the nominal value for fluctuations up to ±20% (compared to ±10% of competitors). Differently from current solutions available on the market, in SSR the voltage is controlled in continuous way and not by steps. This is done by means of a brushless motor that automatically and dynamically adjusts the position of a mobile isolated, short-circuited coil over the fixed coil in the magnetic core. The other very innovative element is the fact that its magnetic core will be made of amorphous materials, which limit losses (-20%) with consequent 20% energy savings and 8% CO2 emissions. In terms of revenues, they will move from 3,0M€ in Y1 to 21,0M€ in Y5, and cumulative EBIDTA will be 20,19M€ by Y5. With a further investment of 970K€ to finalize SSR, the ROI will be 12,44. Thanks to the above-mentioned figures, C&M will be able to hire 29 new staff. It has to be highlighted that C&M aims not only at entering the current global market for voltage stabilizers but at creating a new market that, because of the high costs and low performance of competing solutions has never been properly addressed. This new market comprises small and medium sized industrial and civil entities as well as electricity distributors, for which SSR could solve their issues in voltage regulations.

Keywords: internet of things,voltage fluctuation,voltage stabilization,smart grid,renewable energy,sources,cold ironing
GENEtic VAccine technology and the coronavirus CRISIS: exploring socio-technical change and responsible innovation (GENEVACRISIS) (GENEVACRISIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2024-08-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The coronavirus pandemic has disrupted our ways of living across the globe. This research project will use social science and humanities approaches to analyse the enabling role of the coronavirus crisis in the development and (potential) deployment of emerging genetic vaccine technology, and associated transformations in social values and scientific research practices. Although traditional routes are being utilised to develop vaccine candidates, the pandemic has thrown open doors for the introduction of the state of the art genetic vaccines as an emergency response, e.g. Moderna Inc.’s vaccine candidate ‘mRNA-1273’. The underlying mRNA technology presents a completely new yet unproven therapeutic modality, which scientists believe has the potential to disrupt the drug development domain. In practice, only a few gene therapy approaches have received drug approval, and these are mainly aimed at treating rare hereditary conditions. In contrast, genetic vaccines would potentially be administered to the general population, both healthy and affected. They would hence normalise the mRNA medicine platforms. However, the state of the art mRNA therapeutics in general and genetic vaccine technology in particular is yet to undergo serious scrutiny and analysis from a social science perspective, a gap and original research problem that this project aims to address. The project will examine narratives around the Covid-19 pandemic, and through interviews and focus group discussions with scientists, policymakers, and science communicators will explore its enabling role in the introduction of genetic vaccine technology. Furthermore, it will analyse the ways in which these developments might shift social values and research practices. The research outcomes will provide key insights to policymakers for the governance of DNA and mRNA therapeutics platforms, and enhance social science understanding of how narratives of crisis co-shape our response to emerging science and technology.

Keywords: science and technology studies sts,new and emerging science and technology,medical sociology,sociology of science,science policy,sociology of the life sciences
Enhancing the effectiveness of programs and strategies to prevent youth smoking: a comparative realist evaluation of 7 European cities (SILNE-R)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Ireland,Belgium,Belgium,Finland,Netherlands,Netherlands,United Kingdom,Portugal
Call: Evaluating existing screening and prevention programmes (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-10-01
End date: 2018-10-31
Duration (months): 37.0
Total project cost (EUR): 2999997.5
EU funding (EUR): 2999997.5
Participants: 12
Project status: CLOSED

Cigarette smoking is a main risk factor for premature disease, disability and death in Europe, especially in disadvantaged groups. Prevention of youth smoking is crucial to any strategy aimed at reducing this disease burden in the future. Several potentially effective strategies and programs are available to address youth smoking. However, in practice their impact often appears to be limited, especially among socially disadvantaged youth. There is very little systematic evidence on HOW smoking prevention strategies and programs worked in practice, and WHY some programs seemed to influence youth smoking only in some settings or groups. Yet, such evidence is urgently needed to enable decision makers to use the resources available for smoking prevention in the most effective and equitable way. We will generate such evidence by addressing these HOW and WHY questions in a comparative approach. For Finland, Ireland, Germany, Netherlands, Belgium, Italy and Portugal, we aim to assess HOW strategies and programs to prevent smoking in national and local settings affected smoking behaviour of 16 year olds. Moreover, we aim to assess HOW and WHY this impact varied according to city, school, gender, and socioeconomic group. We will be among the first to apply the approach of “realist evaluation” to the evaluation of preventive programs, and to use this innovative approach to compare European countries. We will acquire primary data that are comparable across these countries, including a quantitative survey among 10,000+ students, and in-depth structured interviews with students and various stakeholders. We expect to make a major contribution to the reduction of disease burden and health inequalities among future elderly populations. We will apply a new method for learning from different countries, and for generating the fine-grained evidence that is needed to develop youth smoking prevention programs that are context-sensitive, cost-effective and equity-oriented.

Keywords: smoking behaviour comparative research realist evaluation implementation research local strategies school based programs gender differences socioeconomic inequalities stakeholder involvement
Enhanced substrates and GaN pilot lines enabling compact power applications (PowerBase)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Austria,Germany,Italy,Austria,Austria,Austria,Austria,Germany,Germany,Germany,Germany,Germany,Italy,Germany,Spain,Spain,Germany,Spain,Spain,Norway,Slovakia,Norway,Belgium,Belgium,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: ECSEL Key Applications and Essential Technologies (IA) (ECSEL-2014-2, 2014)
Start date: 2015-05-01
End date: 2018-06-30
Duration (months): 38.0
Total project cost (EUR): 90254494.23
EU funding (EUR): 19196548.95
Participants: 39
Project status: CLOSED

The key objective of PowerBase “Enhanced substrates and GaN pilot lines enabling compact power applications” is to ensure the availability of Electronic Components and Systems (ECS) for key markets and for addressing societal challenges, aiming at keeping Europe at the forefront of the technology development, bridging the gap between research and exploitation, creating economic and employment growth in the European Union. The project PowerBase aims to contribute to the industrial ambition of value creation in Europe and fully supports this vision by addressing key topics of ECSEL multi annual strategic plan 2014. By positioning PowerBase as innovation action a clear focus on exploitation of the expected result is primary goal. To expand the limits in current power semiconductor technologies the project focuses on setting up a qualified wide band gap GaN technology Pilot line, on expanding the limits of today’s silicon based substrate materials for power semiconductors, improving manufacturing efficiency by innovative automation, setting up of a GaN compatible chip embedding pilot line and demonstrating innovation potential in leading compact power application domains. PowerBase is a project proposal with a vertical supply chain involved with contributions from partners in 7 European countries. This spans expertise from raw material research, process innovation, pilot line, assembly innovation and pilot line up to various application domains representing enhanced smart systems. The supporting partners consist of market leaders in their domain, having excellent technological background, which are fully committed to achieve the very challenging project goals. The project PowerBase aims to have significant impact on mart regions. High tech jobs in the area of semiconductor technologies and micro/nano electronics in general are expressed core competences of the regions Austria: Carinthia, Styria, Germany: Sachsen, Bavaria and many other countries/ regions involved.

Keywords: pilotline for gan semiconductor components,future base materials for power semiconductors,applications where compactness is a high value,research and pilotline for gan packaging
Exploring the Unknown through Reincarnation and Co-evolution (Phoenix)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Belgium,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2014)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 3632486.25
EU funding (EUR): 3632486.25
Participants: 8
Project status: CLOSED

Humans have been exploring the world from the depths of the oceans to the edges of the universe. Yet many environments remain inaccessible, even to modern cutting-edge technology. Therefore problems like exploring the status of waste water under the Fukushima reactor, or discover suitable sites for underground CO2 storage remain unsolved. Our aim is to investigate a new line of technology that will enable the exploration of difficult-to-access environments exploiting a risky, highly-novel approach called PHOENIX. PHOENIX will accomplish the exploration of inaccessible environments with physical agents that are extremely limited in size and resources, and can operate without direct control over software and hardware. PHOENIX starts with processing a user question, then assesses available knowledge and initiates an evolutionary process involving two nested generational loops. In the outer loop PHOENIX develops, deploys and retrieves physical agents capable of penetrating the inaccessible environment and gathering information. Based on this knowledge, a model of the unknown environment is developed and evaluated. This model is refined in the inner loop, where environmental models and abstract representations of the physical agents (virtual agents) co-evolve in a virtual world until an improved generation of physical agents is ready for deployment. The goal of this co-evolution is to maximize the information captured about the unknown environment by progressively optimized agents. Our main objectives are: the development of a co-evolutionary framework, the design of versatile agent technology and the development of a dedicated human interface. PHOENIX is a radically new, high risk/high reward project. It also holds the promise to shed light on emergent properties of self-organization, local adaptation and division of labour in autonomous systems. The high societal benefits, foundational character and long-term focus make PHOENIX a perfect fit for the FET programme.

Keywords: localization,inaccessible environment,evolutional learning,machine learning,sensor fusion,environment exploration,environment modelling,resource constrained sensory,game theory
AttoDNA: how electronic motions affect the photostability of the genomic material (AttoDNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

AttoDNA considers the early (attosecond to few-femtosecond) events following photo-excitation/ionisation in DNA/RNA canonical and non-canonical nucleobases for the first time. This involves the electronic movement before the onset of nuclear dynamics, ascertaining the length in which this initial purely electronic motion extends in time and how it affects the ensuing nuclear dynamics and its outcome with regards to the photostability shown by the genomic material from a bottom-up approach. By monitoring the electronic and nuclear motions in canonical and non-canonical nucleobases, the way in which they couple can be elucidated and the specific motions contributing to photostability extracted from a novel standpoint. Photostability is one of the main properties thought to play a crucial role in the selection of the nucleobase monomers in prebiotic extreme UV exposure, by encoding the genome using the most suitable (photostable) building blocks as an elegant solution to aid in its photo-protective design and thus defend itself against the threat of photochemical damage. Beyond its intrinsic importance given its essential role towards preserving our genomic material, an in-depth knowledge of this outstanding property also provides a unique perspective on the events where these photo-protection mechanisms fail, namely the photo-damage instances, and in the subsequent repair mechanisms mediated by electron transfers as those put in place by enzymes and/or in specific non-invasive treatments like photodynamic therapies, the most widespread treatment for cancer. The project therefore aims at extending the foundations rationalising DNA's photostability by exploring the potential role of the electronic dynamics prior to the onset of nuclear dynamics for the first time and is expected to have a large impact in the fields of photochemistry and photobiology.

Keywords: casscf,caspt2,ab initio,photostability,attosecond