Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of aquatic hyphomycete spores in headwater stream food webs: a food quality approach. (Spor-oikos)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

The functioning of forested headwater streams relies on microbially-mediated processes ensured mainly by aquatic hyphomycetes. They are pivotal systems for human and other biotic communities as they provide water, carbon, and nutrients. The scientific objectives of the Spor-oïkos project are to experimentally investigate: i) the chemical cues inducing aquatic hyphomycetes' sporulation, and ii) the functional role of aquatic hyphomycete spores in headwater food webs, both being blind spots in freshwater ecology. By applying a food quality approach and merging different scientific disciplines and theories (molecular biology, biochemical and elemental theories), this project will unveil a potential hidden pathway of nutrient and carbon (C) flow, offering new insights on the microbial contribution to large scale C fluxes. The biochemical theory studies the ecological role of essential molecules, mainly essential fatty acids and sterols. It is applied to investigate the efficiency of C transfer in trophic interactions. The elemental theory studies how the ratios of elements in organisms (e.g. C, Phosphorus and Nitrogen) shape their ecology and nutrient and energy fluxes in ecosystems. Both theories have successfully been applied to better understand the trophic interactions, and nutrient cycling in terrestrial and aquatic systems. In the last case, these theories have particularly been used to study the producer-consumer interaction in lakes, and it is just recently that they are being applied in detritus-based systems such as headwater streams. This work programme will be articulate by four experiments that have carefully been designed to progressively understand the overlooked importance of fungal spores in stream food webs, and the unknown effects of global changes (mainly eutrophication). Scientists from two high-level laboratories from two European countries will offer their expertise to train the researcher and hence open up the best possibilities for his career.

Keywords: aquatic hyphomycete spores,forested headwater streams,chemical cues inducing sporulation,climate changes,food quality,lipid profiling,nutrient vs biochemical limitation,trophic interactions
Enhancing fuel efficiency and reducing vehicle maintenance and downtime costs, using real-time data from vehicle sensors (IoT) and a machine learning algorithm for big data analysis. (Jam)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Portugal
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Jam is an IoT solution (hardware & software), aiming to improve the efficiency of businesses operating medium/heavy-duty vehicle (e.g. passenger and distribution fleets) and industrial fleets (e.g. mining trucks and agriculture vehicles), targeting key needs: - Fuel efficiency: fuel represented, in 2011, 32% of the total cost of fleet operation - Compliance with environmental regulations and reduction of GHG emissions - Vehicle off-road (VOR) time and maintenance costs: Many operators put the cost of having a single VOR as being in the hundreds, if not thousands, euros/day According to Frost & Sullivan, the OBD market is expected to reach 117.8 million subscribers in 2019 and to become a billion-dollar industry by 2020. Although there are already solutions on the market for ECU interpretation on light-duty vehicles, the amount of new protocols, physical interfaces and differences in details in the way industrial vehicles operate constitute a barrier, not yet surpassed. Business and industrial fleets need an agnostic solution that allows optimizing the fleet management by reducing the maintenance costs and VOR time. Jam brings an innovative approach and focus on prevention and constant analysis of real-time vehicle data through a machine-learning algorithm allowing companies to save money on fuel costs, vehicle parts and hours of labour due to a more efficient management of fleet resources. Competitive advantages: - Designed for medium/heavy-duty and industrial vehicles - Agnostic system - Machine-learning algorithm that compares the ECU sensor data with historical data, predicting critical events - New eco-driving approach - Troubleshooting and scheduled repairs approach focused on prevention and constant analysis of real-time vehicle data The solution will be implemented at a global scale, starting in European markets: Portugal for early market uptake and testing; and then the biggest EU markets (Germany, UK, France, Poland, Italy and Spain).

Keywords: fleet efficiency,fleet productivity,preventive maintenance,downtime costs reduction,real time data analysis,machine learning algorithm,big data analysis,eco driving,ghg emissions reduction
A seamless, continuous torque multispeed Automated Manual Transmission technology that increases fuel and power efficiency (Z-Tech)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-10-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Zeroshift Performance Ltd specialises in the design, development and application of its patented transmission technology “Z-Tech” which enables seamless instantaneous means of changing gear without interrupting engine torque. Currently operating predominantly in the motorsport, Z-Tech is experiencing significant demand for integration in the cruising and domestic use motorcycles. Building upon the success our initial prototypes tested in the cruising motorcycle, we are applying for the dedicated Phase 1 SME funding from the EC to confirm the techno-economic feasibility of our technology for the successful commercialisation. Our business model is to licence our technology to the motorcycle manufacturers who will then take our technical designs and manufacture the gearboxes in their own facilities, ensuring that they are in control of the production processes, and that the product is designed to their specifications. We have strong market-pull from utility providers such as Piaggio Aprilia, GAIUS Transmissions, Harley Davidson Motorcycles and Albins Performance Transmissions. Based on early interest we have built bottom-up 5 year forecasts to generate cumulative turnover of €23.63million to generate €18.9 PBIT. Based on total investments of €2.77million, this will achieve a ROI of 5.8:1 and payback on investment in ~34 months.

Keywords: seamless transmission,seamless gearbox,fuel efficient gearbox,smooth shift quality,refined automatic manual transmission
Rewiring photorespiration using natural and synthetic pathways to sustainably increase crop yield (GAIN4CROPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Estonia,Italy,Germany,Spain,Italy,Italy,Israel,Germany,Switzerland,France,France,Netherlands,United Kingdom
Call: Boosting the efficiency of photosynthesis (RIA) (H2020-NMBP-BIO-2019-two-stage, 2019)
Start date: 2020-05-01
End date: 2026-01-31
Duration (months): 69.0
Total project cost (EUR): 8014100.0
EU funding (EUR): 8014100.0
Participants: 15
Project status: SIGNED

Photorespiration – recycling Rubisco’s oxygenation production, 2-phosphoglycolate (2PG), back to the Calvin Cycle – is an ineluctable process in today’s plants, which dissipates energy and releases CO2. Photorespiration reduces CO2 assimilation efficiency, and thus biomass yield, by ~30% and represents a prime target for improving agricultural productivity, as was demonstrated in several recent studies. Yet, the engineering of alternative photorespiration routes to date is restricted to pathways that release CO2, leaving space of considerable further improvement. Another opportunity to reduce the inefficiencies of photorespiration is to minimize it by engineering C4 metabolism, which serves as a carbon-pump that increases the CO2 concentrations near Rubisco. GAIN4CROPS aims to boost plant productivity using novel strategies to minimize the inefficiencies of photorespiration. GAIN4CROPS will follow a stepwise approach, starting by engineering naturally occurring carbon pumps and culminating with the introduction of highly efficient synthetic metabolic pathways that can dramatically boost carbon fixation. First, we will engineer a C3 crop to operate the naturally-occurring C3-C4 carbon-pump, boosting carbon fixation while requiring less complex anatomical modifications than C4 metabolism and using solely genome editing and wide crosses. This step serves as a conceptually novel, ‘natural’ approach towards engineering C4 metabolism. Second, GAIN4CROPS will develop more efficient synthetic C3-C4 carbon pump variants that are based on the effective intercellular transport of aspartate or malate while conserving cellular resources. Finally, based on C3-C4 metabolism, GAIN4CROPS will explore two innovative photorespiration bypass routes which, rather than releasing CO2, fix inorganic carbon, thus directly assisting carbon fixation. GAIN4CROPS will serve as a research and innovation roadmap to attain similarly higher photosynthetic performance in a broad range of C3 crops.

Keywords: photorespiration,c3 c4 intermediate photosynthesis,enzyme engineering
Microsensor for continuous arterial blood glucose monitoring (GlucoSet)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-10-01
End date: 2020-11-30
Duration (months): 26.0
Total project cost (EUR): 6368407.5
EU funding (EUR): 2376150.0
Participants: 1
Project status: CLOSED

- Poor glucose control in critically ill patients leads to significant increases in costs, complication and mortality rates. Continuous monitoring of glucose will reduce costs of €2700 per patient and could save 58 000 lives in the EU every year. - GlucoSet has developed a disposable glucose sensor for monitoring glucose in the ICU. The sensor measures glucose by measuring sub-nanometer length changes in an advanced material that responds to the glucose level. The product is designed for mass-manufacturing at its core. The innovative fiber optic sensor is protected by granted patents and has freedom to operate. The sensor will be sold as a single-use device lasting 96h with a gross margin of over 90% at high volume. - The total addressable market (US and EU) is $1600 million per year. Willingness to pay has already been confirmed. The project has strong backing from key opinion leaders. - Unlike the competition, the sensor couples to the indwelling arterial catheter, which enables unsurpassed reliability and ease of use. - The SMEi phase 2 will take the project from working prototypes that have been tested in vivo, to a CE-marked device. We expect market entry in 2021 in the EU. - The company has a very strong team that has extensive experience with medical devices, scaling up production and raising and working with venture capital.

Keywords: hydrogel probe,continuous glucose monitoring,critically ill patients
Development of Impentri, an intravenous imatinib formulation for Covid-19 acute respiratory distress syndrome (ARDS). (Impentri)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: France,Netherlands,Canada,United Kingdom
Call: Development of therapeutics and diagnostics combatting coronavirus infections (H2020-JTI-IMI2-2020-21-single-stage, 2020)
Start date: 2020-07-01
End date: 2022-10-31
Duration (months): 28.0
Total project cost (EUR): 3985732.0
EU funding (EUR): 3662963.0
Participants: 5
Project status: CLOSED

The accumulation of fluid in the lungs is a significant feature of the pathology in patients with severe Covid-19 infection. This build up of fluid, contributes to difficulty in breathing and in some cases death. This fluid in the lungs results in part from direct damage to cilia and mucus cells and resulting debris and in part due to plasma extravasation triggered by the immune response to infection and associated damage. Imatinib, a generic marketed drug has been shown to reduce plasma extravasation following inflammatory challenge in animal models and this effect is supported by anecdotal observations in the clinic. This project proposes to rapidly implement a multi-center, randomized, open label, double-blind, Phase IIb study to evaluate the efficacy, safety and pharmacokinetics of imatinib mesilate in patients with corona-virus associated pneumonitis. 100 patients entering ICU with a diagnosis of corona-virus associated pneumonitis will be randomised, half receiving i.v. imatinob , 200mg bid for 5 days and one half placebo. Adverse events, immunological parameters and imatinib pharmacokineticswill be monitored. Outcome measures Primary: PaO2/FiO2 ratio. Secondary: rate of intubation/need for mechanical ventilation, pulmonary edema on high resolution CT, Oxygenation Index, respiratory mechanics, duration of mechanical ventilation, fluid balance, ICU length of stay, mortality. This project has already received EMA scientific advice for the treatment of acute respirator y distress syndrome and has granted orphan drug status.

Keywords: development of impentri,an intravenous imatinib formulation for covid 19 acute respiratory distress syndrome ards
Simulating the dynamics of viral evolution: A computer-aided study toward engineering effective vaccines (ENGEMED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2022-07-03
Duration (months): 36.0
Total project cost (EUR): 236457.0
EU funding (EUR): 236457.0
Participants: 2
Project status: CLOSED

The adaptive immune system mounts pathogen-specific responses against diverse microbes and establishes memory of past infections thus constituting the basis of vaccination. Although major advances have been made in understanding pertinent molecular and cellular phenomena, an understanding of the mechanistic principles that govern the emergence of an immune response has proven so far to be elusive. An example of a consequence of this missing knowledge is the inability to design a vaccine against HIV. The difficulty in elucidating the mechanistic principles underlying adaptive immune responses are due to the fact that the pertinent processes involve cooperative dynamic events with many participating components that must act collectively for a given phenomenon to emerge. Many groups around the world work on designing vaccines by trying to stimulate good antibodies that will neutralize the virus. In this project we propose an alternative strategy: by means of harnessing the cellular immune response, or the T cell immune response, which controls virus infected cells and controls infections in the body; this strategy might not prevent infection but it can certainly prevent disease. For this, computer-aided approaches will offer the possibility of defining fitness of highly mutable pathogens (and cancers) so that to facilitate rational design of vaccines and therapies. The proposed computer modeling of viral dynamics, can offer an unprecedented means to identify vulnerable regions of the virus through the application of statistical mechanics-based computer simulation of the evolution dynamics of escape mutants in HIV, guiding this way the engineering of efficacious vaccine immunogens for diverse viruses.
Fundamental physics in the era of gravitational-wave astronomy (FunGraW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The first gravitational wave (GW) detections by the Laser Interferometric Gravitational-wave Observatory (LIGO) are an historical landmark. These detections opened a completely new window to the Universe and officially marked the beginning of GW astronomy. GWs travel almost unimpeded through the Universe, thus conveying clean information about their sources. This gives us a unique opportunity to test the nonlinear regime of Einstein’s theory of general relativity (GR) to unprecedented levels. Indeed, the GWs detected so far were emitted by the merger of binary black holes (BHs) which are the prototypical sources to investigate gravity in its most extreme regimes. However, the true potential of GW observatories to discover new physics beyond of current knowledge is far from being fully explored. In fact, besides probing the nature of compact objects and testing GR, GW detectors may also revolutionize our understanding of particle physics, dark matter (DM) and even possibly quantum gravity. At small scales, with the advent of precision GW physics we will be probing regions closer to the BH horizon, potentially ruling out or confirming alternatives to BHs that predict corrections at the horizon scale. On the opposite side of the spectrum, GWs may also give us hints about the nature of large scale anomalies, such as the existence of DM. For example, light bosonic fields around compact objects, i.e. BHs and neutron stars (NSs), can trigger superradiant instabilities and emit long-lived monochromatic GWs that can be used to either probe the existence of new particles beyond the Standard Model or, in the absence of detections, impose strong constraints on their masses and couplings. The prime goal of this proposal is to understand what GWs can tell us about fundamental questions such as the nature of compact objects and DM and ultimately to contribute to the recent theoretical efforts in developing the full scientific potential of the newborn field of GW astronomy.

Keywords: strong gravity,superradiant instabilities,ultralight bosons,exotic compact objects
Novel Arthritis Treatment with focus on natural Chitin Oligosaccharides (Simecos)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Iceland
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Osteoarthritis (OA) is one of the leading causes of global disability, especially among the Elderly populations – approximately 10–12% of the adult population in the world has symptomatic OA. Specifically, it affects more than 40 million people in Europe. Currently there is no cure for OA – there are no current therapies available that can reverse or halt the progression of osteoarthritis. OA's control strategy mainly consists of palliative pain treatment as there are several medicines on the market can alleviate pain and improve function in OA patients (e.g. analgesics, NSAIDs, opioids). Genis offers a revolutionary approach for the resolution of inflammation and tissue regeneration for OA patients - SIMECOS. SIMECOS is a biocompatible and bioactive drug, derived from Genis' patented food supplement BenectaTM , which provides less risk of side effects, reduced patient recovery time, protection of articular tissues, reduced scar tissue formation and increased success rate for treating OA disease.Genis' approach has been validated in a relevant environment (in vivo and in vitro studies) supported by Pre-Clinical and Phase I Clinical trials for BenectaTM, showing safety of the compound and its pronounced effect of resolution of inflammation and tissue regeneration. Genis is a small innovative biotechnology company from Siglufjörður, Iceland, whose aim is to discover, develop and commercialize novel and life changing pharmaceutical products, supplements and medical devices derived from crustacean exoskeletons. With their novel biocompatible and bioactive drug SIMECOS they seek to disrupt the pharmaceutical market for OA's treatment, and to access a more than €45 billion market in Europe.

Keywords: arthritis,inflammation,osteoarthritis