Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
HIstory of CAre in the MAghreb. Infectious diseases, healthcare infrastructures and international aid (1956-1999) (HICAMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,Morocco
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 4
Project status: SIGNED

The HICAMA project explores the development of healthcare in the Maghreb region by examining the historical interactions among national sanitary institutions, civic experiences of health outreach, and international institutions involved in global health preservation. The Covid-19 pandemic has demonstrated the strategic importance of studying infectious diseases in a variety of contexts and from multiple angles. Focusing on containment and eradication programs against infectious diseases promoted over the second half of the twentieth century, HICAMA examines the efforts made by Maghreb independent countries against the spread of diseases with both a respiratory and a sexually transmitted nature. The project conceptualizes the fight against infectious diseases as a first and yet enduring test for healthcare systems' viability in the region. HICAMA adopts a multilayered perspective to assess local, national, and international implications of the phenomenon: it takes into account Algerian, Moroccan, and Tunisian sanitary endeavors against infectious diseases, the role of international donors (WHO, World Bank, USAID) in directing Maghrebi healthcare politics, and considers the local and gendered practices of care implemented by associations active for decades to promote outreach programs. Drawing on archival sources, official and press sources, and interviews, the project employs a novel methodology that combines archival research, oral history, institutional and gender analysis. By recasting the healthcare as a prism through which nation-building, international relations, and local activism can be reassessed - a methodology reproducible also in other contexts - HICAMA aims to have a major impact on the history of the modern Maghreb. Ultimately, HICAMA includes research, communication and dissemination activities in the Maghreb, Europe, and the United States that will enhance the Fellow's research skills and her global approach in studying the history of the MENA region.

Keywords: history of maghreb history of healthcare global history of medicine infectious diseases sanitary diplomacy health activism nation building international aid algeria morocco tunisia
Rethinking the landscape of host defences against emerging viruses (ReThink)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1545746.0
EU funding (EUR): 1545746.0
Participants: 2
Project status: SIGNED

All recent viral pandemics originated following human adaptation of zoonotic viruses. Our front-line antiviral defences are a major barrier to these viruses. Specifically, our cells encode antiviral proteins -that can be species-specific-, and directly inhibit viral entry, replication, and spread, thus influencing the outcome of infection. Current dogma states that antiviral proteins induced by interferon signalling, named interferon stimulated genes (ISGs), are the most significant front-line of defence. However, as ISGs are induced upon recognition of an already replicating virus, I hypothesize that an array of proteins that are constitutively expressed act to contain the initial wave of viral infection before the more specific and potent ISGs are expressed, thus providing a critical first-line of defence that influences pathogenesis and interspecies transmission. Supporting this hypothesis, my recent genome-wide multi-OMICs investigation of dengue (DENV) and influenza virus (IAV) restriction revealed that 75% of the proteins that inhibited viral infection are non-ISGs. Integrative analysis of these proteins revealed enrichment in general cellular pathways, -many not previously linked to viral restriction-, with significant enrichment in homeostasis maintenance. Moreover, depletion of one single of these proteins resulted in 100% mortality in infected mice, confirming their role in pathogenesis. Using DENV as a model of emergent WHO-priority virus, I will now characterize how these proteins inhibit DENV and other related (west Nile and zika) and unrelated viruses (IAV) (Objective 1). I will investigate their impact on DENV pathogenesis using attenuated and virulent clinical isolates (Objective 2) and as barriers of interspecies transmission using ex vivo models (Objective 3). Overall, this work will shift our understanding of antiviral defences, opening a new area of research that offers signatures of pathogenesis, surveillance, and broad-acting antiviral targets.

Keywords: pandemic viruses,host defences,emergent viruses
Self-AwaRe NEuromorphic ArChiTectures: Security, Reliability and Energy-Efficiency (REACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Germany,Israel,Italy,Belgium,United Kingdom,Sweden,India,Austria
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 4963444.41
EU funding (EUR): 4565860.92
Participants: 18
Project status: SIGNED

Self-awareness in humans is a natural tendency. This self-awareness is processed by the human brain based on various inputs received from the body's sensory systems. Mimicking this functionality on an electronic platform, also known as neuromorphic computing, can result in highly intelligent machines that could be utilized in many day-to-day activities. These activities range from autonomous cars to smart navigation assistants. However, neuromorphic computing faces several challenges, including energy efficiency, reliability, and security. In the REACT MSCA Doctoral Network project, we aim to develop a neuromorphic platform that is self-aware from the perspectives of energy efficiency, security, and reliability. The project seeks to train 15 early-stage researchers (ESRs) in interdisciplinary domains such as material science, device physics, computer architecture, hardware prototyping, compilers, simulation and emulation frameworks, security, reliability, and verifiability. The REACT doctoral network is a carefully designed training program where ESRs will receive mentorship from leading academics and industry partners. Additionally, ESRs will gain expertise in scientific writing, ethics, research principles, time management, and entrepreneurship. The REACT project is committed to enhancing the skills of ESRs through research-intensive training. By the end of the REACT project, we envision new opportunities for ESRs to thrive in their respective careers, with REACT serving as the ideal launchpad.

Keywords: self awareness,emerging technologies,security,reliability,energy efficiency
Defining an integrated model of the neural processing of speech in light of its multiscale dynamics (SPEEDY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2028-09-30
Duration (months): 72.0
Total project cost (EUR): 1897100.0
EU funding (EUR): 1861100.0
Participants: 1
Project status: SIGNED

This interdisciplinary project will define an integrated model of speech processing by recording, modelling and manipulating neural oscillatory dynamics during perception of speech defined as a multiscale temporal signal. Dominant models of speech perception describe its underlying neural mechanisms at a static neuroanatomical level, neglecting the cognitive algorithmic and neural dynamic levels of description. These latter can only be investigated by considering the temporal dimension of speech, which is structured according to a hierarchy of linguistic timescales (phoneme, syllable, word, phrase). Recent advances in behavioural paradigms, computational modelling, and neuroimaging data analysis make it now possible to investigate the cognitive algorithms and neural dynamics subtending the processing of speech. To define an integrated model of speech perception, this project seeks to: 1. record neural activity in humans with magnetoencephalography and intracranial recordings during perception of continuous speech; 2. quantify linguistic information at each timescale of speech with a computational model; and 3. estimate their respective and shared neural correlates with multivariate and directed connectivity analyses. Feasibility is ensured by an in-house access to neuroimaging and intracranial recordings as exemplified in the data on Figure 1 of this proposal. This project will critically test whether neural oscillations play a fundamental role in the computational processes of perception and cognition. It will define the mapping between speech and neural timescales and reveal how information is transferred and combined along the linguistic computational processing hierarchy. It will overall specify -in terms of the nature of the information processed and of the dynamical hierarchical organization- the respective contributions of left and right hemispheric ventral and dorsal auditory pathways in speech processing.

Keywords: humans cognitive and systems neuroscience speech perception neuroimaging linguistic acoustic computational modelling neural dynamics information theory
GLObal GOvernance of LABour: an integrated approach (GLOGOLAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 2
Project status: SIGNED

The project 'GLObal GOvernance of LABour: an integrated approach' (GLOGOLAB) aims to investigate in a comprehensive way the emergence of different transnational regimes of regulation of work in response to the increased integration of the world economy. The project uses a MSCA Global Fellowship to leverage on my expertise on multi-level economic governance, industrial relations and labour sociology and bring it from a continental to an even more relevant global level. It will be hosted by the Department of Political and Social Sciences at Scuola Normale Superiore, under the supervision of Prof. Guglielmo Meardi, who is a leading scholar in the field of labour sociology and industrial relations, and by the ILR School at Cornell University in the US (host of outgoing phase), under the supervision of Prof. Sarosh Kuruvilla, world-renowned scholar of employment relations in global supply chains. The action has three specific research objectives First, to provide a comprehensive mapping of different forms of global governance of labour emerged with the increased transnationalisation of the world economy, building a database covering the last three decades (1990-2020) (RO1), Second, to analyse and compare the impact on workers’ rights of different global labour governance structures and the different strategies adopted by social forces vis-à-vis them, through an in-depth comparative analysis of four critical cases drawn from the database (RO2). Third, drawing from different theoretical approaches (industrial relations, multi-level governance, social movement studies), to refine an analytical approach which is able to account for the complex policy processes and outcomes taking place within global governance of labour structures (RO3). By proposing an integrated approach to the study of global governance of labour the project will therefore make a significant empirical and theoretical contribution.

Keywords: global governance of labour,industrial relations,sociology of work,social movement studies,multi level governance,transnational opportunity structures
Harnessing Seagrass Rhizosphere Microbiome for New Antimicrobials (SeaRhi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Today the drug discovery pipelines are lacking of novel compounds to combat challenging infections caused by multidrug resistant bacteria (MDR). According to the World Health Organization, maintaining an intensive academic effort towards the discovery and development of new antimicrobials is urgently needed. Bioprospecting for new antibiotics sourced from untapped environments, such as marine ecosystems, is of vital importance. As such, seagrass meadows represent an emblematic marine ecosystem and a niche for understudied marine microorganisms. While much is known about the rhizosphere microbiomes of terrestrial plants, little is known about the seagrass’ ones. This project raises two questions: What is the seagrass microbiome and its antimicrobial metabolites? and, are these molecules naturally produced and secreted in the rhizosphere? Taking advantage of the host institution’s expertise within natural products chemistry, microbiology, biochemistry and genomics the four objectives of SeaRhi are: (1) to create a microbial strain collection of microorganisms associated with the seagrass rhizosphere, (2) to discover new microbial metabolites and characterize their biosynthesis (3) to systematically evaluate their antimicrobial properties against MDR bacteria, and (4) to determine if the (anti)microbial metabolites are produced in the ecosystem. SeaRhi will address technical challenges using innovative strategies to study marine microorganisms directly in their ecological niche by developing cutting-edge in situ devices to isolate marine microorganisms and collect the molecules they produced and released in environmental conditions. Thanks to an interdisciplinary ecosystem-focused strategy and the integration of knowledge between the fields of engineering, microbiology, marine natural product chemistry and (meta)genomic, SeaRhi will provide a better understanding of the seagrass ecosystem while discovering new antibacterial microbial metabolites.

Keywords: natural products chemistry,chemical ecology,plant microbes interactions,microbial ecology,drug discovery,marine biodiversity
S=Smart U=Upgraded asset-values and quality of life P=Public Private Partnership E=Extended Energy Efficiency R=Renewables triggered by the project SH=Social Housing I=Investment N=Net Zero E=European (SUPERSHINE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Belgium,Italy,Portugal,Denmark,Latvia,Spain,Türkiye,Serbia,United Kingdom,Ireland
Call: Social and affordable housing district demonstrator (IA) (HORIZON-CL4-2021-RESILIENCE-02, 2021)
Start date: 2022-11-01
End date: 2026-03-31
Duration (months): 41.0
Total project cost (EUR): 2244512.03
EU funding (EUR): 2075558.0
Participants: 22
Project status: SIGNED

The objectives and impacts of the SUPERSHINE project will assist and support the European Commission to implement the European Green Deal. Particular attention will be paid to the renovation of social housing, to help households who struggle to pay their energy bills. In addition, SUPERSHINE will also contribute to the decrease of energy poverty. The SUPERSHINE lighthouse districts will be characterised by energy efficient buildings, low carbon mobility, smart grids, efficient water and waste management, all underpinned by responsive technologies that optimise resources while promoting wellbeing and sustainable lifestyles. More specifically, SUPERSHINE will adopt an integrated strategy with these key principles: a)‘Energy efficiency first’; b) Affordability; c) Decarbonisation and integration of renewables; d) Life-cycle thinking and circularity; e) High health and environmental standards by promoting sustainable energy behaviours; f) Tackling the twin challenges of the green and digital transitions together; g) Respect for aesthetics and architectural quality. The main areas of intervention are: a) Strengthening information and incentives for public and private owners and tenants to undertake renovations while improving community participation or inspiring new patterns of citizen behaviour; b)Ensuring adequate and well-targeted funding by supporting innovative bottom up financial solutions such as Public Private Partnerships (PPPs) and Green Public Procurement (GPP) and collaborating with innovative local Small and Medium Enterprises (SMEs); c) Promoting comprehensive and integrated renovation interventions; d) Making the construction ecosystem fit to deliver sustainable renovation, based on circular solutions, use and reuse of sustainable materials, and the integration of nature-based solutions while reducing whole life-cycle carbon emissions.

Keywords: bottom up business models social innovation slca social housing district renovation environmental cost benefit analysis crowdfunding one stop shop blueprint model optimal social discount rate
Innovative and safe microwave-based imaging technology to make breast cancer screening more accurate, inclusive and female-friendly (MammoScreen)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Portugal,United Kingdom
Call: Develop new methods and technologies for cancer screening and early detection (HORIZON-MISS-2021-CANCER-02, 2021)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 6043547.19
EU funding (EUR): 6043547.19
Participants: 7
Project status: SIGNED

Breast cancer (BC) is the most common cancer in women worldwide, affecting 1 in 8 women. The figures from WHO’s International Agency for Research on Cancer estimate that in 2020 worldwide cases of breast cancer accounted for 24% of all cancers in women (2.26 million women and 685,000 deaths globally). Mammography is the gold standard technology for breast screening, which has been demonstrated through different randomized controlled trials to reduce breast cancer mortality. However, it has limitations and potential harms, such as the use of ionizing radiation, breast compression and performance restrictions due to the intrinsic nature of X-rays. In particular, breast density is a restrictive property that can prevent breast cancer detection in mammograms of women with radiographically dense breasts. Other existing techniques (MRI, Ultrasound, biopsy) also suffer from drawbacks. The overall aim of the MammoScreen proposal is to generate evidence about the use of MammoWave (a technology developed by UBT) as screening technique in population-based programs promoted by National or Regional Health Systems, to reach a revolution in breast screening. To do so, the consortium aims to confirm that MammoWave reaches sensitivity>90% and specificity>95% in BC detection on 10000 study participants undergoing regular screening programs. MammoWave uses safe non-invasive and non-ionizing microwave signals, does not apply any compression to the breast and is very effective with dense breasts. Hence it can extend the breast screening to younger women aged 20-49 (98 million women in Europe). This group accounts for ~30% of breast cancers in 2020. A comprehensive health economic assessment will be undertaken in this project and innovative way to implement patient engagement approaches is sought. An effective policy makers’ engagement plan will be carried out to ensure that MammoWave is recommended as screening approach due to the benefits that it brings to women and healthcare systems. This action is part of the Cancer Mission cluster of projects on ‘Prevention, including Screening.

Keywords: breast cancer screening,microwave technology,quality of life,