Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PRivacy preserving pOst-quantuM systEms from advanced crypTograpHic mEchanisms Using latticeS (PROMETHEUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Research and Innovation actions
Partnership: Cybersecurity PPP (cPPP)
Countries involved: Germany,Spain,Israel,Switzerland,France,France,France,France,Netherlands,Netherlands,United Kingdom
Call: Cybersecurity PPP: Cryptography (H2020-DS-LEIT-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 5496968.94
EU funding (EUR): 5496968.75
Participants: 17
Project status: CLOSED

Privacy-preserving cryptographic protocols allow users to take common daily life actions online (e.g, purchases, reservations or voting) without leaking sensitive personal information. They typically combine various tools such as digital signatures, homomorphic encryption or zero-knowledge proofs. While practical solutions exist under RSA or discrete logarithm assumptions, they are all completely vulnerable to quantum attacks, so that working quantum computers would immediately make them obsolete. To address this threat, the PROMETHEUS project will enable users' privacy in the post-quantum world by providing a complete toolbox of innovative, efficient and quantum-secure cryptographic techniques adapted to modern services. It will provide new building blocks in relation with international competitions and standardisation processes, as well as advanced properties dedicated to the design of sophisticated protocols. To this end, PROMETHEUS will focus on lattice-based cryptography and first conduct an in-depth study of the hardness of lattice problems in the quantum world, which will drive the development of better basic tools for lattice-based cryptography. Then, it will give a new set of practical primitives (signatures, public-key encryption, pseudorandom functions, etc) and suitable methods to combine them with efficient zero-knowledge proofs. These new tools will lead to the design of practical advanced protocols, like anonymous credentials, digital cash or electronic voting, that maintain users' privacy against quantum adversaries. The security of these protocols will be considered in its entirety, from theoretical definitions allowing quantum accesses to certain functionalities to practical implementations accounting for side-channel leakages. As a concrete outcome, PROMETHEUS will highlight the feasibility of post-quantum privacy via demonstrators for several real-life use cases, including electronic payments, e-voting and cyberthreat intelligence.

Keywords: post quantum,lattice based cryptography,e cash,e voting,anonymous credentials,cyberthreat
Vaccine profiling and immunodiagnostic discovery by high-throughput antibody repertoire analysis (Antibodyomics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 1492586.0
EU funding (EUR): 1492586.0
Participants: 1
Project status: CLOSED

Vaccines and immunodiagnostics have been vital for public health and medicine, however a quantitative molecular understanding of vaccine-induced antibody responses is lacking. Antibody research is currently going through a big-data driven revolution, largely due to progress in next-generation sequencing (NGS) and bioinformatic analysis of antibody repertoires. A main advantage of high-throughput antibody repertoire analysis is that it provides a wealth of quantitative information not possible with other classical methods of antibody analysis (i.e., serum titers); this information includes: clonal distribution and diversity, somatic hypermutation patterns, and lineage tracing. In preliminary work my group has established standardized methods for antibody repertoire NGS, including an experimental-bioinformatic pipeline for error and bias correction that enables highly accurate repertoire sequencing and analysis. The overall goal of this proposal will be to apply high-throughput antibody repertoire analysis for quantitative vaccine profiling and discovery of next-generation immunodiagnostics. Using mouse subunit vaccination as our model system, we will answer for the first time, a fundamental biological question within the context of antibody responses - what is the link between genotype (antibody repertoire) and phenotype (serum antibodies)? We will expand upon this approach for improved rational vaccine design by quantitatively determining the impact of a comprehensive set of subunit vaccination parameters on complete antibody landscapes. Finally, we will develop advanced bioinformatic methods to discover immunodiagnostics based on antibody repertoire sequences. In summary, this proposal lays the foundation for fundamentally new approaches in the quantitative analysis of antibody responses, which long-term will promote the development of next-generation vaccines and immunodiagnostics.

Keywords: diagnostics,infection,next generation sequencing,bioinformatics
Sustainable innovation of microbiome applications in food system (SIMBA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Iceland,Spain,Italy,Ireland,Italy,Italy,Norway,Finland,Norway,Belgium,Netherlands,Netherlands,Netherlands,Denmark,Portugal,Denmark,Portugal
Call: Microbiome applications for sustainable food systems (H2020-SFS-2018-1, 2018)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 10373931.62
EU funding (EUR): 9999999.77
Participants: 23
Project status: SIGNED

As the world population is continuously increasing, the supply of food with equal accessibility has become a major issue and future challenge. Microbes are unexploited tool to increase food productivity and quality. The objective of SIMBA project is to harness complex soil and marine microbial communities (microbiomes) for the sustainable production of food. SIMBA will focus on two interconnected food chains, i.e. crop production, aquaculture. SIMBA will first launch an in silico phase in order to analyze the further pre-existing microbiome databases and earlier studies, to identify the best microbiome layout capable of supporting food chain quality and productivity. Microbiome-tailored interventions will be specifically developed including soil, plant, fish, aquaculture and food/feed processing towards optimal layout as defined in the modelling step, as follows: i) Identified optimal microbiome consortia will be designed and tested in lab, pot and field trials to improve plant productivity and health; ii) Marine microbiomes will be applied to facilitate sustainable aqua and agriculture; iii) Optimal microbe/microbe consortia will be used to convert raw-materials and residuals to high quality food, feed or finally to energy. In a final intervention step, these interactions will be monitored and tested in field, aqua-culturing, fish feeding and human studies, measuring the impact on microbiome consortia, interactions in association with factors evaluating their efficacy in terms of improving food security, productivity, quality, safety, sustainability, nutritional and health aspects. "Near to market” microbiome applications for sustainable food systems will be provided thanks to the interdisciplinary and cross-sectional nature of the proposal and the active role of small and medium sized enterprises (SMEs).

Keywords: soil,marine,food,human
Comorbidity of cHronic Pain and mood disorders: breaking the vicious cYcle (HaPpY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Spain,Ireland,Finland,France,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 3945686.04
EU funding (EUR): 3945686.04
Participants: 8
Project status: SIGNED

The increasing number of patients with comorbidities poses an urgent need to improve their management. Among these comorbidities, chronic pain and mood disorders, two long-lasting disabling conditions that significantly reduce quality of life, could be cited first. Given the importance of this comorbidity, we believe that only research considering both pathologies in an integrative way can achieve the required insights into the underlying mechanisms that are necessary to identify novel diagnostic tools and treatment strategies. To respond to this health and societal emergency, we propose to establish a network of academic institutions and companies to provide 15 early stage researchers (ESRs) with a top quality international training programme. The HaPpY network is comprised of higher education institutions with very well-established track records of scientific and academic excellence, and of research institutes with significant experience and cutting-edge approaches in fundamental research on mood disorders or/and pain. To ensure that discoveries in fundamental research can swiftly move toward clinical settings, to the benefit of patients and society, our consortium is enriched by clinical centres, companies and other non-academic partners. This consortium thus enables a unique research and training programme by combining and integrating the complementary strengths of each partner. HaPpY will thus provide ESRs with a broad scientific knowledge and foster their creative skills which will enable them to become leaders in either the academic or non-academic sectors. We believe that only a coordinated programme aiming to train a new generation of talented and multidisciplinary researchers can succeed in our ambitious endeavor to break the vicious cycle linking pain and mood disorders.

Keywords: comorbidity,pain,depression,human studies,rodent studies,sexual dimorphism,neuroscience,medicine,pharmacology,diagnostic,treatment strategies
Next Generation of Mechanics with Hazard-Responsive Surface (NGenMech)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

80%+ of failures in machines using lubricated moving parts (bearings, gears, camshafts etc.) is due to the damaging operational condition called starved oil lubrication. Recurrent exposure to this state is the bottleneck of performance and durability for such machinery. End-users are happy to pay more for reliable and durable engineering products, but state of the art offers only costly and deficient workarounds to the key peformance-limiting problem. A disruptive approach to enhance oil lubrication specifically under the critical damaging conditions is recently viable due to high-frequency ultra-short pulse lasers (HFUSPL) having become affordable outside the realm of high-end applications. By using HFUSPLs the micro- and nanoscale patterning of surfaces is possible with unprecedented precision. Such patterning activates a novel and highly effective oil lubricant delivery mechanism expressly under critical contact conditions, resulting in 3x reduction of friction coefficient, improved performance and reliability, reduced maintenance – doubling the lifetime of the entire machinery. This technology has been advanced to TRL6: real textured engine parts demonstrated in model engines. To make NGenMech available for industry it needs to be automatised using an optoelectric control unit, duly parametrised for the market entry use case, and piloted by a selected industrial partner. To engineer this workplan, a feasibility study will assess potential markets, analyse business model and partnership options, and evaluate commercialisation and IPR strategies to select Primary Use Case and define Strategic Business Plan. As R&D and tech transfer company, IfU Diagnostic Systems GmbH is engaged with several large industrial companies interested in commercialising NGenMech technology. NGenMech will double the lifetime of machinery while reducing maintenance need. The powerful cascade impact over the entire value chain of mechanical engineering cannot be overestimated.

Keywords: oil lubrication,responsive surface,surface texturing,laser micromachining,wear resistance
Characterization of the molecular mechanism behind CTL - the major choline uptake system in eukaryotes (CTL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

Choline is an essential nutrient necessary for the synthesis of the membrane lipids phosphatidylcholine and sphingomyelin that constitute over 50 % of the total lipid content in cellular membranes. It is the precursor for key metabolites such as the neurotransmitter acetylcholine and the osmolyte and methyl donor betaine. Transmembrane uptake of choline is the essential, but still enigmatic, first step in choline metabolism in the cell. Three groups of solute carriers have been identified in the transport of choline; CHT1, OCT and CTL (SLC5A7, SLC22, SLC44 in humans). While CHT1 and OCT perform specialized functions, the choline transporter-like (CTL) family facilitates the majority of choline uptake in all eukaryotes. Despite their clear physiological relevance, our knowledge of CTL family members is very limited, and there are no structures of choline transporters available. For this reason, knowledge on the molecular mechanism of cellular choline uptake is almost non-existent. With this proposal, I will address this lack of data, and provide new and ground-breaking insights into the function of the CTL family members. I will elucidate the molecular mechanisms of substrate recognition and transport in the major eukaryotic choline uptake system through a combination of structural biology (X-ray crystallography and cryo-EM) and biochemical characterization. The project will focus on human CTL family members but will also include other eukaryotic CTL proteins. A structural framework on the CTL family will provide insight into a key metabolic uptake pathway present in all eukaryotes and will be a fundamental resource for further research. Furthermore, CTLs are implicated in several diseases, including cancer, and the proposed work on CTL proteins will allow for future pharmacological studies addressing these with great impact on society.

Keywords: membrane protein,choline transporter like ctl,solute carrier 44 slc44,membrane transport,x ray crystallography,cryo em
Innovation Associate knowledgeable in blockchain technology for real time economy platform business development (DLInnociate)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Finland
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 131472.5
EU funding (EUR): 131472.5
Participants: 1
Project status: CLOSED

DLI Ltd operates right now in a synergetic business landscape where the development of national information society and the client assignments collide in a manner profitable for the company. DLI Ltd need to complement its expertise with knowledge in blockchain technology for secured Real Time Economy in cloud, both in general for providing applications to any client and for piloting the DEEP, Digital Enterprise Ecosystem Platform business plan on open innovation with a client in the FinTech. The plan targets to leverage the business plan further within the client’s global organization, one of the world's largest settlement system for domestic and international securities transactions. The employment of the Innovation Associate will base on the mutually developed and agreed Personal Career Development Plan which will be first time discussed during the recruitment phase together with the Training Plan suggested by the company. The personnel of DLI Ltd offer an innovative working environment in a team of professionals in production design and software development as well as ecosystem builders, innovators and people with a high academic degree familiar with practicalities in science. Street smart business out of latest in science meets at this knowledge intensive SME. The Innovation Associate is free to use her or his full potential to contribute to the client assignments and to the tasks in the workplan, as well as to create a career of her or his own at DLI Ltd on the generated Innovation Plan in long run. As the DLI Ltd’s LifeEngine platform is applicable in any field and DLI Ltd is highly skillful in ecosystem building with stakeholders of the full operational chain, DLI Ltd has appealed clients in demand of latest and future Internet technologies in several fields. This offers the Innovation Associate the possibility and freedom to cowork with most advanced commercial solutions.

Keywords: cloud computing,blockchain,platform development,real time economy,secured asset management and transactions,knowledge management
KOMP Pro - The one-button screen connecting care providers and family with non-digital seniors through pictures, messages, video, apps and services. (KOMP Pro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

That the European population is ‘turning grey’ is causing both increasing costs connected to senior care, and the realization that we need more carers than we have. Care providers are currently trying to effectivize care by means of telephone and smartphone-/tablet-care-apps, but telephone contact is insufficient and many seniors do not know how to use modern technology. To meet this need, No Isolation wish to develop KOMP Pro, a one-button computer developed for tech-averse seniors. Our solution will allow care providers to video-call and message patients, but also enable the integration of useful and life-enhancing apps and services through an open API. KOMP Pro simplifies care. The future of care will be radically different. KOMP Pro aligns with the EU’s development of a disruptive Digital Industrial Platform, which will ensure the integration of different key technologies such as robotics, sensors, big data and mobile communication, via open APIs and IoT-based smart living environments/wearables.

Keywords: silver economy,digital contact,digital divide,seniors
GLObal-scale interactions between MAngrove forests and Climate (GLOMAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Covering 0.5% of the global coastal area, mangrove forests are among the most carbon-rich forests on Earth and account for >10% of total terrestrial carbon input to the ocean. As a result, mangroves provide a vital link between the terrestrial and oceanic carbon cycles and have been placed as a climate-change mitigation component on the international policy agenda. Despite their ecological and socio-economical importance, and the role they play in climate regulation, an increasing amount of evidence indicates that their geographic distribution is shifting in response to climate change, impacting human welfare, ecosystem functioning, and potentially also the dynamics of climate itself. I propose to study the GLObal-scale interactions between MAngrove forests and Climate (GLOMAC) by assessing, for the first time (1) the export, transport, and fate of carbon from mangrove forests in the ocean and its contribution to carbon sequestration in the global ocean and atmosphere and (2) the potential effect of climate change on the global distribution of mangroves and the role of different environmental factors therein. This ambitious goal will be achieved by (1) extending a novel global-ocean biogeochemistry model (ECCO-Darwin) with mangrove-ocean carbon fluxes derived from the first high-resolution (30 m) global mangrove canopy height dataset and (2) integrating mangrove habitat suitability estimates into a global-ocean dispersal model (ECCO-Dispersal). GLOMAC provides an important first step toward integrating coastal and global carbon cycles and will help improve understanding of the impact that global warming may have on the geographic distribution of mangroves and coastal ecosystem services. The resulting modelling tools can be refined upon availability of future data and will be useful and informative to studies in other coastal and marine ecosystems, global (blue) carbon programs, as well as the economic sector (e.g., fisheries, dredging, and marine engineering).

Keywords: mangroves,modelling,carbon,ocean biogeochemistry,species distribution models,range shifts,dispersal,habitat suitability,climate change,coastal wetlands,remote sensing