Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Drivers' behavioural adaptation over the time in response to ADAS use (ADAPTATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France,Germany,Germany,Germany,France,United Kingdom,Sweden,Netherlands,Austria,Portugal
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 2537189.0
EU funding (EUR): 2537189.0
Participants: 10
Project status: CLOSED

The objective of ADAPTATION is to improve the career perspectives of young researchers by taking part in an innovative European research programme aiming at investigating drivers&apos; behavioural adaptation and its underlying processes over the time in response to Advanced Driver Assistance Systems (ADAS) use. The research programme integrates, under a joint theoritical framework and a joint longitudinal methodological design, a set of individual projects dealing with the various aspects of the adaptation process. In addition to training-through research, personalized training actions will extend the skills of this future generation of academia and industry researchers. The training programme implemented during the ITN lifetime aims to accelerate acquisition of skills in Human Factors applied to ADAS design, to favour multi-disciplinary approaches, to strengthen to disseminate research results and to widen the career prospect with complementary skill on team and project management. Through its research and training programmes, ADAPTATION will contribute both to the development of the ERA and to an increase of EU competitiveness. The competitiveness of the European Industry and the implementation of their products will be improved by better response of ADAS to the drivers&apos; needs and requirements. The European community will also benefit from the education of high skilled professionals and the development of durable training programmes for a future generation of researchers.

Keywords: psychological sciences,cognitive science,societal behaviour,user centred design,active safety of vehicles,information technology
Virtual Atomic and Molecular Data Center (VAMDC)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: France,United Kingdom,United Kingdom,United Kingdom,Austria,Sweden,Germany,Italy,United Kingdom,Serbia,Russian Federation,Venezuela, Bolivarian Republic of
Call:  (FP7-INFRASTRUCTURES-2008-2, 2008)
Start date: 2009-07-01
End date: 2012-12-31
Duration (months): 42.0
Total project cost (EUR): 3393220.0
EU funding (EUR): 2900000.0
Participants: 15
Project status: CLOSED

Many research groups and institutes within the European Research Area (ERA) are playing a central role in the production of a vast range of atomic and molecular (AM) data, data that is of critical importance across a wide range of applications such as astrophysics, atmospheric physics, fusion, environmental sciences, combustion chemistry and in industrial applications from plasmas to lighting. Through the auspices of this infrastructure the Virtual Atomic and Molecular Data Centre (VAMDC) aims to build a secure, documented, flexible and interoperable e-science environment-based interface to the existing AM data. The VAMDC will be built upon the expertise of existing AM databases, data producers and service providers with the specific aim of creating an infrastructure that is easily tuned to the requirements of a wide variety of users in academic, governmental, industrial or public communities both within and outside the ERA. The project will cover the building of the core consortium, the development and deployment of the infrastructure and the development of interfaces to the existing AM databases as well as providing a forum for training potential users and dissemination of expertise across the ERA. It is expected that VAMDC becomes a European legal entity during the course of the project.

Keywords: atome - molecule - standardisation of exchanges - quality assurance of e-infrastructure - grid operation -
Molecular mechanisms of mRNA decay (MRNA DECAY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-07-01
End date: 2013-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

All organisms require a reliable mechanism to turn genes on and off. This regulation of gene expression underlies cellular processes ranging from the response to environmental signals to the development of multi-cellular organisms and cell-cell communication. Understandably, the cell tightly controls gene expression at every step from DNA to protein. Recent work has given new insights into these control mechanisms and revealed dedicated pathways (including non sense mediated decay) that target mRNA for degradation, thereby efficiently turning genes off. Here, we propose to study the molecular mechanism that underlies the degradation of mRNA. Although many of the proteins involved have been identified, little is know about how the activity of the degradation machinery is regulated on an atomic level. We will study one of the core components, the DCP1:DCP2 decapping complex, that removes the protecting 5' cap structure from the mRNA. Specific question we will address range from the structure of the complex in solution, the catalytically important molecular motions and the way protein-protein or protein-RNA interactions can either activate or inhibit the activity of the decapping complex. We will use of nuclear magnetic resonance spectroscopy, to study these structure, motions and interactions. As these complexes involved can be of high molecular weight, we will exploit recently developed NMR methodology in concert with novel sample preparation techniques. In addition, we will extend our structural studies with in-vivo studies, where we can study the effect of mutations in residues that were found to be important for function. The interdisciplinary nature of this project and the use of a state-of-the-art structural approach promises to provide unique insights into the way cells regulate gene expression by removing mRNA from the transcriptional pool.

Keywords: structural biology,biological sciences,biochemistry,molecular biology
Environmental VARIableS RegulaTing DivErsity and FaUnal DistributionS in Canyon and Lower Slope Ecosystems of the Western Mediterranean (ARISTEUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-03-16
End date: 2012-03-15
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Major questions about the functioning of marine ecosystems on the continental margin concern their interrelationship/dependence on the natural drivers (physical and geological processes), as they are strongly physically and geologically mediated and potentially affected by human and climate change perturbations. Indeed, recent studies in the Western Mediterranean have demonstrated that flows triggered by dense shelf water cascading transport large amounts of water and sediment from the shelf to the deep basin. Cascading waters directly affect the functioning of the deep ecosystem by providing a fast way of fuelling highly nutritive, fresh organic matter to the deep, transforming brusquely authentic biological deserts in real oases. In addition, water and sediments transported from the coastal zone can act as preferential transfer vectors for contaminants, which may affect negatively marine ecosystems. Therefore, this highly energetic mechanism of flushing of dense shelf waters may be crucial to control benthic community structure, but little is now at the moment. The main objective of the ARISTEUS (Environmental VARIableS RegulaTing DivErsity and FaUnal DistributionS in Canyon and Lower Slope Ecosystems of the Western Mediterranean) project is to carry out multidisciplinary research in canyon and lower slope ecosystems of the Western Mediterranean aimed at i) characterize the physical (water column current regime and near-bed current regime) and biogeochemical (sediment transport, seabed composition, input of particulate organic matter) factors regulating diversity and faunal distributions, and ii) determine how do these environmental variables influence biological communities (establishment of the relationships between the abiotic factors and the spatial and temporal structure of meio-, macro- and megafauna populations) with special attention to the deep-sea living resource Aristeus antennatus.

Keywords: deep-sea ecosystems,biogeochemistry,geological oceanography,chemical oceanography,environmental indicators (environment,fisheries and aquaculture interactions)
Investigation of a new strategy for the controlled-release of drugs from bioresorbable inorganic matrices (CONTRELL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-09-15
End date: 2012-09-14
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Although extensive research has been carried out in the past few years to develop strategies for controlling the release of highly toxic therapeutic agents (such as cancer drugs) in the body, most drug-delivery systems still produce unsatisfactory results in vivo. The overall goal of this work is to tackle two of the main drawbacks of current devices, 1- by favouring the release of the drugs via a well-known mechanism (i.e. the breaking of well-defined bonds which will have been created between the therapeutic molecule and the drug-carrier matrix), and 2- by using inorganic drug-carrier matrices selected for their bioresorbability. In this project, the study will focus on a subset of purposely chosen systems (drugs with a phosphonic acid or boronic acid function), in order to reach the following key targets: 1- the synthesis and complete structural analysis of materials in which a drug is linked via well-defined (iono)covalent bonds to a bioresorbable inorganic matrix, 2- the measurement of the reactivity and stability of these (iono)covalent bonds in vitro, and the understanding of their sensitivity to various parameters (pH, temperature, rate of degradation of the carrier matrix…). In the long term, this work should open the way to new strategies for the rational elaboration of efficient drug-delivery systems. The project is expected to significantly boost the research career of the applicant, by allowing her not only to combine the various skills she has acquired during her PhD and post-doc, but also to acquire new competences in the multidisciplinary field of drug-delivery biomaterials. She will find at the Institut Charles Gerhardt in Montpellier both the scientific expertise and equipment necessary to carry out this work.

Keywords: structural chemistry,pharmaceutical chemistry,inorganic chemistry,molecular chemistry,analytical chemistry
WORK SYSTEMS AND CAREER ADVANCEMENT (WSCA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-11-01
End date: 2014-06-12
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The Researcher proposes to investigate the determinants of individuals’ career advancement in the current organizational landscape in the US and in Europe. Specifically, the Researcher will investigate how recently adopted participatory work systems, which decentralize decision making to lower level jobs, have transformed the traditional bureaucratic model of career advancement in organizations. The proposed project has three main research objectives. First, the Researcher will present an analysis of how participatory work systems, characterized by high employee involvement practices such as self-managing teams and employee suggestion systems, affect the opportunities for career advancement in organizations in the US. Theoretical arguments for why these new work systems change opportunities for career advancement will be advanced and tested. Second, the Researcher will expand the research to the European context. The impact of participatory work systems on individuals’ careers in different countries will be investigated and compared. The role of the institutional context in explaining the differences found will be investigated. Existing datasets will be used for these analyses. Finally, the Researcher will investigate how the adoption of high participatory systems affects the career dynamics of individuals at one organization. The Researcher will collect a unique dataset and will present an econometric case study. The proposed project will benefit the European community in several ways. It will contribute to enhance EU scientific excellence by producing high-impact scientific publications and by establishing collaboration with Professors at other prestigious institutions in the US. It will also benefit the Community by developing an under explored research field in Europe that will have important implications for productivity and employment outcomes.

Keywords: work systems,employee involvement,career advancement,promotions,wage growth,matched employer-employee data,multilevel analysis,econometric case study,us-europe comparison,flexibility.
Development of a new method for brief compound exposures to ion channels proteins using an automated patch clamp platform (NANIONLIGAND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-06-15
End date: 2012-06-14
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The gold standard for obtaining data on ion channel function is the patch clamp method. The patch clamp technique is very labor intensive and has ultra low data throughput which has been highly motivating for the development of automated patch clamp systems. Nanion has developed a technology for performing automated patch clamp recordings on planar glass substrates, with comparable recording quality as with conventional patch clamping, however, lacking the possibility to very briefly expose the cells to different solutions. If exposure times are too long, this can have adverse effects when investigating ion channels that activate on the addition of agonists (ligand gated ion channels). Ligand gated ion channels are gaining more attention in research and drug development because of their involvement in disease. These ion channels often display desensitization, resulting in a diminishing compound response, during constant stimulation. Recovery kinetics often depends on exposure time, thus are brief exposure times desirable. We aim at developing a method for very short compound exposure using automated patch clamp by combining microfluidic structures for liquid administration to the patch clamp substrate. A robotic pipettor arm applies all solutions to the microchannels and by subsequently aspirating two differnt solutions of buffer into the pipette, and immediately adding this “stack“ of solutions to the cell, the cell experiences a very brief exposure of agonist, directly followed by wash buffer. This way, exposure times are anticipated to be shorter than 1 second, with switching times in the order of 50 ms. This would allow for accurate experiments on ligand gated ion channels that exhibit rapid desensitization , which in turn would be useful in ion channel research on channelopathies, and to facilitate the drug development of compounds modulating ligand gated ion channels.

Keywords: physiological biophysics,nanobiotechnology
Cold goes south. The emergence of refrigeration technologies in the European South. The case of Greece (late 19th-20th centuries). (COLDGR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-10-01
End date: 2012-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The field of the history of artificial cold is of particular interest to historians, sociologists and anthropologists of science, technology and medicine on two counts: it is a domain where science, technology and industry have often been closely linked, as well as a field in which European science, industry and technology have excelled. Moreover, it is a domain that invites studies of issues related to a number of social transformations brought about by the extensive use of artificial cold in the latter part of the 19th century, and especially during the 20th century. The development of industrial and domestic refrigeration and transport brought about amazingly varied and long lasting changes in urbanization and everyday life, whose impact ranged from changes in the habits of eating, the organization of family life, women’s everyday life, home architecture, use of appliances etc. With the proposed ERG project our aim is two-fold: Firstly, we aim to map the appropriation of refrigeration technologies in Greece (late 19th-20th centuries) 2. The use of mechanical refrigeration in Greece goes hand in hand with the industrialisation of the country throughout the 20th century, the development of its critical infrastructures, the emergence of new actors such as technicians and their associations, but is also inseparable from more general social and cultural issues, such as concepts about ‘fresh’ and ‘perishable’ produce. Secondly we aim to add to existing literature a new dimension through the examination of the expository practices of some of the main actors behind refrigeration. A careful examination of a wide range of specialist and non-specialist texts and the discourse developed around refrigeration will bring to the fore the values and ideas associated with the increasingly important role of refrigeration for the immediate prospects of modern society, but also the interests of specific groups of people that often clashed with existing local market.

Keywords: history of science,history of technology,history of women in science,european studies,cultural anthropology
Modular design of organocatalysts by combination of subunits effective in complementary catalytic mechanisms (MODDESGNORGCAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-05-01
End date: 2012-04-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The selective catalysis by conventional and simple organic molecules, despite of its simplicity, has created an extraordinary impact on chemistry. Not only the continuous emergence of organocatalysts increases the availability of tools for the efficient synthesis of new products, but also contributes to the understanding of the mechanisms of actions of more complicated catalysts, as for example, the relevant natural enzymes. The first organocatalytic were discovered almost by chance, after the examination of the behavior of (sometimes well-known) natural products (as, for example, proline) with conventional reactants. Nevertheless, the discover of a second generation of organocatalysts requires a careful design based on the knowledge of the reaction mechanisms. This design usually consists in the modification of existing and successful organocatalyst, to enhance (or suppress) few of its characteristics. In contrast, in this proposal we suggest the employment of a modular approach to this design, consisting first in the identification of the chemical units responsible for the catalysis, and secondly in a simple design of the correct combination of these fragments, according to the mechanism of the desired reaction. In the first step, the fragments responsible for catalysis will not only be inspired in the wide spectra of organocatalyst published so far, but also in the identification of the role that different aminoacid residues plays in the overall catalytic activity of enzymes. This open the possibility of obtaining an extremely valuable information of the enzymatic mechanism based on the mechanism of the synthetic, modular, organocatalysts, which has to be considered very positively jointly with the relevance of providing new catalysts to the arsenal of synthetic organic procedures.

Keywords: homogeneous catalysis,organic chemistry,computational chemistry
Advances in Spectroscopic Monitoring of Styrene Emulsion Polymerization (ASMOSEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Lithuania
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-04-01
End date: 2011-03-31
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

This project proposes further advancement and development of the novel spectroscopic method i.e. of its current state of the art, created during Marie Curie ITN research project INTROSPECT. Although it promises a noticeable breakthrough in Process Analytical Technology (PAT) of monitoring concentrations in particulate/turbid media it is in an embryonic stage and its practical applicability is yet unanswered question. A number of applicability issues must be solved for its successful implementation in a particular industrial process. The focus of this project is the application of this method to styrene emulsion polymerization.

Keywords: spectroscopic monitoring of concentrations of chemical components,styrene emulsion polymerization