Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SMART Emerging Electronics Servicing DIH (SmartEEs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Belgium,Finland,Belgium,France,Czechia,Netherlands,United Kingdom
Call: Smart Anything Everywhere Initiative (H2020-ICT-2016-2, 2016)
Start date: 2017-09-14
End date: 2020-11-13
Duration (months): 38.0
Total project cost (EUR): 4836951.25
EU funding (EUR): 4550548.75
Participants: 10
Project status: CLOSED

The market for organic & printed electronic products is growing at a high level (BUS$ 23-24 in 2014) with predicted annual growth rates of 20 % in all fields. Although the use of OLAE in products is still limited and only have been commercialized by large corporates, the number and type of products has grown significantly. These emerging markets are a huge opportunity for the EU industry. But EU small & mid-size companies have had only a limited access to technologies and often lack the capabilities needed to benefit from OLAE. These include the ability to fully understand the technological implications and the related business implications. They need support in the translation of the OLAE technologies into innovative products, assessing potential markets, finding investors, developing new business models and creating the right partnerships to optimally benefit from OLAE opportunities. SMARTEES will be the Digital Innovation Hub dedicated to OLAE, an organized European innovation network that provides both access to competencies and business support for innovation adoption. SMARTEES will help the European industry to create a competitive advantage within the global economy by providing access to disruptive OLAE technologies and innovation support in a pragmatic, operative and efficient pan-European manner. A 1-Stop-Shop will be set to establish a collaborative environment and to provide wider access to the technology at the same time as coordinating the bespoke services and efficiently and effectively linking them together. 20 Application Experiments will be conducted to explore the technology transfer into business, organization of cooperation, access to finance, services to be provided and act as showcases to raise awareness and activate potential users. The established eco-system will be harnessed by the consortium to propel the continuity of the initiative beyond SMARTEES. This will include the formulation of a comprehensive business plan as a strategic outcome.

Keywords: digital,innovation,thin,large,area,organic,electronics,1 stopshop,support,smes
InnoBremen4 - Establishing Services enhancing the innovation management capacities of SMEs in the Federal State of Bremen (InnoBremen 4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 62920.0
EU funding (EUR): 59000.0
Participants: 2
Project status: SIGNED

The following proposal addresses the topic “Specific activities in the context of innovation support (Horizon 2020) “, namely the in-depth services enhancing the innovation capacity of SMEs. Innovation is a key driver for the success of enterprises, a requirement for their competiveness and thus a precondition for exploiting international opportunities in the Single Market and beyond. Offering growth-oriented business and innovation support services to SMEs is therefore seen as the core task of the Enterprise Europe Network. Although Innovation Management is crucial for SMEs, empiric data has proven that SMEs still show the inability to manage innovation processes efficiently and effectively as the second most important barrier to SME innovation. Enterprise Europe Network Bremen will offer the services to ensure that SME beneficiaries of H2020 European Innovation Council (EIC) Pilot are able to exploit their full Innovation potential. Therefore services are designed and offered to enhance the innovation management capacities of SMEs as an integral part of the hub and spokes approach of the Enterprise Europe Networks Services, addressing the innovation needs of SME’s to establish an Innovation Management System (basis: technical specification CEN/TS-16555-1 , published by the European Commission) in the respective enterprises.

Keywords: innovation capacities,innovation services,innovation management,key account management services,kam services,sme instrument,eic pilot
Comparative Models of Megalithic Landscapes in Neolithic Atlantic Europe (MegaScapes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The idea that Europe’s Atlantic façade shares elements of a common culture rooted deep in prehistory has long fascinated geographers and archaeologists, and finds expression in modern political organisations such as the Atlantic Arc Commission. The MegaScapes project will use the latest statistical and quantitative methods to examine whether the explosion of megalithic construction across Europe’s Atlantic façade between 5000-2500 BC (and especially 4500-3500 BC) provides evidence of a shared understanding across distant regions of the Atlantic European seaboard as long ago as the Neolithic. It will undertake a comparative study of four important micro-regions of megalithic construction spanning the United Kingdom, Ireland, France and Spain, which will use advances in computational and spatial statistical modelling to analyse spatio-temporal patterns in the arrangement of megalithic monuments, and their possible meaning in a wider landscape context. The latter will be inferred by rigorously investigating regularities in the geographical placement of megaliths, trends in their visibility, their association with pathways and their relation with the lived environment such as settlement and land use. Ultimately the core aim of MegaScapes is to investigate whether the spatial meaning of Neolithic megalithic architecture was regionally variable, or whether it was indeed shared along the Atlantic European seaboard.

Keywords: megalithic complex,spatial analysis,computational modelling,landscape archaeology,site,predictive modelling,point pattern analysis
Beyond hydrodynamics (QuasiHydro)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

What do black holes and particular exotic materials, where strong correlations preclude any description based on weakly-coupled quasiparticles, have in common? Their low energy dynamics are expected to fall within the regime of effective field theories, such as hydrodynamics, where the dynamics are governed by the flow of conserved densities based on the symmetries of the system. However it is often hard to know what the boundaries of this regime are. This is even more true when a system is “quasi”-hydrodynamic meaning one of the conserved quantities, such as the number of particles, decays due to the presence of a “breaking parameter”. Gauge/gravity dualities are relationships from string theory that connect classical black holes to particular quantum theories that have the unusual property of rapidly becoming (quasi)hydrodynamic when perturbed. I seek to use gauge/gravity dualities to answer the following questions: When is quasihydrodynamics a good description of nature (in particular for large values of the breaking parameter)? For what ranges of parameters is it applicable? The first question can be explored by considering models of interdisciplinary relevance and searching for commonalities through which we can categorise them. To answer the second we can make use of the special properties of gauge/gravity theories - the existence of relationships between distinct models (dualities) to compute new results from old. The Marie Curie fellowship will allow me to strengthen my position as the intermediary between condensed matter and string theory, with this project as the initial bridging point. I will use the fellowship to increase my output in high impact journals (e.g. Physical Review Letters), apply for longer term grants and gain knowledge in a new area of physics (condensed matter) through the guidance and experience of my project supervisor Dr.~Blaise Goutéraux. He is the ideal host for this proposal, having extensive experience in these areas.

Keywords: string theory,cft correspondence,quasihydrodynamics
Rack Mountable Soliton Microcomb with Turn-Key operation for Scientific and Industrial Applications (RaMSoM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: SIGNED

The invention of the optical frequency comb (OFC) has enabled counting of optical frequencies and has thereby given rise to optical atomic clocks that today are even sensitive to the gravitational redshift and are of crucial importance for future improvements to navigation, positioning, and timing. The early generation of OFC based on mode-locked lasers are already commercially available but suffer from a number of limitations in terms of system size and complexity, and notably, low attainable repetition rates (<10 GHz). However, higher repetition rates (>10 GHz) are essential in many applications. The discovery of microresonator-based Kerr frequency combs (microcombs) has revolutionized the field and paved a route to a compact OFC, with broad optical bandwidth and repetition rates in the microwave to terahertz domain (10 GHz - 1 THz). Despite such undeniable advantages of soliton microcombs over other types of OFCs as chip-scale footprint and unique combination of high repetition rates and broad bandwidth reaching an octave, there is however no commercial product that would expose the soliton microcomb technology to the market and offer an optical frequency comb with similar performance and scale. The focus of the RaMSoM project is to design and build the world's first 19"-rack-mounted stand-alone soliton microcomb source with the turn-key operation and demonstrate its performance and reliability in scientific and industrial applications. The project will pursue the following objectives: (1) development of a turn-key reliable soliton microcomb source in a 19"-rack chassis; (2) employment of the developed stand-alone system for novel scientific applications, including multi-wavelength broadband spectroscopy and neuromorphic optical computing; (3) development of an industrial-grade soliton microcomb system with enhanced tuning functionality and demonstration of field applications in cooperation with industrial partners.

Keywords: soliton microcombs,kerr dissipative solitons,optical microresonator,spectroscopy,dual comb spectroscopy
EXercise as a regulator of hepatic NAD metabolism and MItochondrial function in Non-Alcoholic fatty liver disease (EXNADMINA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-02-28
Duration (months): 18.0
Total project cost (EUR): 146591.1
EU funding (EUR): 146591.1
Participants: 1
Project status: CLOSED

Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in industrialized countries, including Europe, and comprises a spectrum of disorders ranging from hepatic lipid accumulation (steatosis) to inflammation (non-alcoholic steatohepatitis, NASH) and fibrosis. Pathogenic pathways leading from hepatic steatosis to NASH are still incompletely understood resulting in a lack of approved therapeutic options besides life style changes. Physical activity is effective to prevent NAFLD progression. The mechanism of exercise action on liver mitochondrial metabolism is not clear yet. However, exercise might exert its positive effects via increasing hepatic nicotinamide adenine dinucleotide (NAD) levels. Several studies showed that the hepatic NAD metabolism is dysregulated during the development of NAFLD and that exercise has a positive effect on NAD metabolism and function of NAD dependent enzymes in skeletal muscle. The functionality of mitochondrial metabolism is highly dependent on the maintenance of the organellar NAD pool. Mitochondrial dysfunction has been implicated in the progression from steatosis to NASH. We hypothesize that a dysregulated NAD metabolism in the liver is involved in the development of hepatic mitochondrial dysfunction in NAFLD/NASH. Our overall aim is to define the impact of exercise on hepatic mitochondrial dysfunction and test whether exercise effects are mediated via restoration of NAD metabolism. We will achieve this by combining the knowledge on hepatic NAD metabolism of the fellow with the expertise in exercise mouse models and on analysis of mitochondrial function of the Supervisor. This study is one of the first to comprehensively examine the interaction between exercise, mitochondrial dysfunction as a cause of NAFLD and NAD metabolism specifically in the liver and in hepatocytes and ultimately aims to identify novel therapeutic targets for the prevention and treatment of NAFLD.

Keywords: non alcoholic fatty liver disease,exercise rodent model,nicotinamide adenine dinucleotide,hepatic insulin resistance
Histone H3.3 oncogenic mutations: a role in genome instability through altered DNA repair and replication fork stability? (HiMIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-10-20
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 118880.25
Participants: 1
Project status: CLOSED

Genome instability is a hallmark of cancer and is caused by the accumulation of DNA damage. Genome integrity is preserved by DNA repair machineries that operate on a chromatin substrate where DNA wraps around histone proteins. Interestingly, point mutations in histone H3.3 in particular have been identified as drivers of tumorigenesis. Beyond their impact on gene expression, some of these mutations were recently shown to inhibit homologous recombination-mediated repair of DNA double-strand breaks (DSBs) in human cells (K36M mutation) and to contribute to replication fork stability in yeast cells (G34R mutation). Furthermore, H3.3 histones are deposited de novo at sites of DNA damage in human cells. These findings call for a more systematic characterization of the impact of H3.3 mutations on genome instability. We hypothesize that H3.3 point mutations may alter the cellular response to DNA damage, thus leading to malignant transformation. Here, we propose to test this hypothesis through a set of complementary approaches in human cell lines. We will initially examine whether H3.3 mutations affect histone deposition at DSBs and at damaged replication forks and chromatin relaxation at DSBs. Next, we will evaluate whether H3.3 mutations affect DSB repair and replication fork stability and repair, ultimately inducing genome instability. We will then evaluate the potential clinical applications of our results by testing whether H3.3 mutations may in turn impact drug sensitivity. These complementary research angles should help understanding whether H3.3 oncogenic mutations affect genome integrity independently of their impact on gene expression, providing new molecular bases for their oncogenic potential. This work might ultimately identify druggable defects that confer chemotherapeutic sensitivity to H3.3 mutated tumors, thus providing a proof-of-principle for potential targeted therapies.
Nicotine actions on beta cell function in health and disease (NACHO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

Tobacco abuse elevates the risk of developing type 2 diabetes (T2D). This effect is attributed to nicotine, the major addictive compound in cigarettes and chewing tobacco. Nicotine acutely activates nicotinic receptors (nAchRs) while extended exposure results in receptor desensitization. Accumulating evidence suggests that long-term exposure to nicotine impairs beta cell function. Recent results (host laboratory) demonstrate that nicotine acutely modulates insulin secretion and that reduced nAchR expression in beta cells results in an increased risk for developing T2D. This suggests that activation of nAchRs is critical for beta cell function. However, the precise mechanisms to modulate beta cell function upon long-term exposure to nicotine in healthy and metabolically compromised conditions, have not been determined yet. NACHO will investigate the effects of nicotine on insulin secretion using MafA mutant animals (model for beta cell dysfunction lacking specific nAchRs (Chrnb2/4)) and human islets. Molecular mechanisms by which nicotine affect insulin secretion will be studied by generating stable clones (CRISPR/Cas9) of human beta cells (EndoC-βH2) lacking CHRNB2/4 and evaluating cell signaling responses (calcium/sodium influx, exocytosis, plasma membrane potential) to nicotine/acetylcholine. The role of long-term nicotine exposure on beta cell adaptability will be assessed in diet-induced obese WT and MafA mutant mice treated with nicotine and evaluating beta cell function and proliferation in vivo (glucose tolerance) and ex vivo (insulin secretion and immunohistochemistry). The clinical impact of specific nAchR gene risk alleles and nicotinic signaling on insulin secretion will be evaluated in non-diabetic humans. Understanding how nicotine influences beta cell function in diabetes development is of considerable clinical interest since tobacco abuse is common and smoking cessation therapy is widely used. NACHO will aid to develop personalized medicine.

Keywords: nicotine,beta cell function,insulin secretion,calcium signaling,obesity,personalized medicine
Multifunctional Nanoparticles and Materials Controlled by Structure (NANOMATCON)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Framework Partnership Agreement
Countries involved: Germany,Czechia,Czechia
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-04-29
End date: 2020-04-28
Duration (months): 60.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 3
Project status: CLOSED

Multiscaled structure-tuned materials with exactly predefined hierarchical architectures composed of multifunctional nanoparticles represent a class of the most advanced future materials for applications in nanobiotechnology, nanomedicine, lighting technologies, green energy resources as well as in military and security branches. The CxI Centre in Liberec will expand its current activities in the field of nanomaterials and engineering technologies by integrating multiscaled 3D-printing machines combined with wet nanochemistry robotics in order to create the aforementioned breakthrough materials. These activities fully correspond to the agenda defined in Horizon 2020. The project belongs to the CEP themes of composite materials (JI), biotechnology (EI) and non-nuclear energy, consumption and utilization of energy (JE).

Keywords: multifunctional nanoparticles,optoelectronics,solar systems,bioprecursors,nanochemistry,3d laser printing
Near-Infrared Optoelectronic Devices with Atomically Controlled Graphene Nanostructures (atoGRAPH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-10
End date: 2022-02-09
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

The extraordinary and ultrafast electro-optical response of graphene nanostructures has enabled order-unity changes in absorption due to the switching on and off of plasmons via electrical gating, thus suggesting application to ultrafast light modulation. Unfortunately, graphene plasmons have so far been observed at mid-infrared and longer wavelengths, therefore limiting their use as optoelectronic devices in the visible and near-infrared (vis-NIR) spectral range. Reaching this energy regime requires an efficient doping of graphene by confining the lateral dimension below 5 nm, which is beyond the state-of-art top-down lithography resolution. Alternatively, this project will use a bottom-up chemical route recently developed by the host organization to synthesize atomically precise, 1nm wide, graphene nanoribbons (GNRs) that can couple laterally to give rise to either nanoporous graphene structures or laterally interconnected GNRs arrays, for efficient gate-doping. The project aims to explore the feasibility of fabricating optoelectronic devices based on the plasmonic properties of atomically precise graphene nanostructures. The nature of the project is highly multidisciplinary, involving a combination of well-developed chemistry, physics, electronics and photonics that will focus at three different levels: chemical synthesis of atomic-size GNRs and characterization, nanostructure transfer and device fabrication, and electro-optical characterization. This proposal promotes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. The proof-of-concept of such device will pave the way for ultra-high speed photodetectors that are capable of handling record data transmission at vis-NIR range, thus providing key solutions for next generation data communications. This project lines up perfectly with the EU strategy, “Graphene Flagship”, in fostering the emergence of foundational breakthroughs in graphene science.

Keywords: graphene nanoribbons,scanning tunneling microscopy,electronic transport,gate tunable,doping,plasmonics,strong light matter interaction,nanophotonics,photodetector,optical communications