Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Earthquakes And community Resilience Through Historical analysis (EARTH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,Jordan
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 5
Project status: SIGNED

EARTH (Earthquakes And community Resilience Through Historical analysis) project explores the social and economic impact of earthquakes on Eastern Mediterranean societies during the Late Roman period (4th-6th centuries CE). It aims to highlight the characteristics of different societies that have suffered from earthquakes and analyse the theoretical and practical responses generated by these natural disasters. For these reasons, the ER has chosen to explore the Negev area from the 4th to the 6th century CE. This choice allows the researcher to analyse if earthquakes influenced human settlement choices, how different societies reacted to a catastrophic event, and how central powers changed their strategies. Today, as in the past, earthquakes continue to be an unpredictable and frightening phenomenon. They are examples of the power of nature and the impotence of man. EARTH project contributes to the recent flowering of integral regional studies, in which geography and topography, the history of settlements and migration, the study of trade routes, economic processes, and political organisation play an important role. Even earthquakes that did not have a significant impact were sometimes mentioned by ancient writers. Therefore, historians inevitably encounter this topic. By focusing on earthquakes and the events they triggered, my project compares societies at times when they were pushed to go beyond their limits and actively or reflexively deal with this circumstance. Studying ancient earthquakes is mandatory not only to explore historical seismology, but also because it allows us to better understand human societies, their resilience and their relationship with the past.

Keywords: environment,resilience,earthquakes
3P-Tec - Three-parent breeding technology for plants of the future (3P-Tec)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Netherlands
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-07-01
End date: 2025-10-31
Duration (months): 40.0
Total project cost (EUR): 2498828.75
EU funding (EUR): 2498828.0
Participants: 3
Project status: SIGNED

Background: There is an urgent need for an agricultural revolution to generate climate-resilient cultivars, which combine proven traits with novel qualities adapting crop plants to climate extremes, including heat and drought. Novel breeding technologies can make the difference to enable farmers to achieve high yields with climate-robust crops to secure food supplies for the world's population. Breakthrough technology: In the framework of the ERC Consolidator Grant "bi-BLOCK" we discovered that plant egg cells can fuse with two sperm producing offspring with three parents instead of two - one mother and two fathers - bypassing a hybridization barrier that is a major limitation for conventional plant breeding approaches. The three-parent breeding technology (3P-Tec) literally opens the way for exploiting beneficial traits of previously incompatible climate-adapted wild species. In the framework of the ERC Proof of Concept grant "TriVolve", we teamed up with one of the world's leading plant breeding companies (KWS Saat SE & Co. KGaA), and successfully transferred the strategy to sugar beet as an experimental crop prototype. Objectives: The development of the 3P-Tec technology for further crop plants including potato, the establishment of technologies that enhance the efficiency of obtaining three parent plants, and the commercial exploitation of 3P-Tec are aims of this project. The project capitalizes on the breeding know-how, worldwide networks, and commercialization expertise of the breeders Aardevo and KWS. Impact: 3P-Tec will revolutionize the ability of breeders to develop improved crops in providing a tool to mine beneficial gene variants of currently incompatible species and to substantially shorten time to market of climate-adapted seed varieties. It provides a novel breeding strategy with economic benefits expected to positively affect the social welfare of farmers as well as upstream and downstream industries related to the agricultural value chain.

Keywords: sustainable agriculture,food security,climate resilient crops,commercial exploitation
Integrating (Epi)Lipidomics for Advanced ASCVD Risk Prediction (WIDER-MIRACLE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Finland,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 29.0
Total project cost (EUR): 599866.25
EU funding (EUR): 599866.25
Participants: 2
Project status: CLOSED

The MIRACLE project seeks to establish a new gold standard in predictive modeling for atherosclerotic cardiovascular disease (ASCVD) by harnessing multi-omics data—including genomics, transcriptomics, proteomics, and metabolomics. Our goal is to improve early diagnosis, treatment, and prevention strategies. In collaboration with our widening partner, UAveiro, the WIDER-MIRACLE Hop-on project will introduce (Epi)Lipidomics as an essential and complementary layer to our research. This addition will expand our biomolecular analysis, allowing for a more thorough exploration of the molecular layers, biological mechanisms, and biochemical pathways that underlie the initiation, progression, and phenotypic manifestations of ASCVD. It will also enhance our understanding of individual differences in susceptibility and resilience to the disease.

Keywords: metabolomics,lipidomics,epilipidome,biomarker atherosclerotic cardiovascular disease,coronary artery disease,peripheral artery disease,stroke,risk prediction
Motivations, causes and consequences of losers’ consent and its breakdown in established democracies (CONSENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1999438.0
EU funding (EUR): 1999438.0
Participants: 1
Project status: SIGNED

Losers’ consent is both a foundation of democracy and one of the big puzzles in political science. In democracies, elections divide citizens between winners and losers, and the expectation is that losers consent to be ruled by the winners. Despite the established notion that losers' consent is fundamental to democracy, recent events like the 2021 Capitol attack in the U.S. and the 2023 Congress attack in Brazil highlight its fragility. Without the losers’ consent, democracies are in danger. This project addresses three central questions: 1) how can we conceptualize and measure consent; 2) which are the determinants of the losers’ consent and its breakdown, and 3) what are the consequences of the breakdown of consent. This research will provide a novel and comprehensive conceptualization of consent that encompasses three dimensions: acceptance of election results, recognition of the winners’ legitimate authority, and willingness to be governed by them. In addition, the project will develop a new typology of consenting losers based on their rationalization of electoral defeat and motivations to accept the legitimacy of the government. This typology will be validated using qualitative data. The project will then develop an original quantitative measure of consent. This measure will be used to track consent in a large set of countries over a long period, and explore the factors that shape it. Special attention will be paid to the role of elites’ narratives and policy proposals in enhancing or eroding losers’ consent. Finally, the project will explore for the first time the impact of the breakdown of consent upon voting, contentious political behavior and social cooperation. Using a range of methods – focus groups, cross-country surveys, longitudinal analysis, and survey experiments across twenty established democracies – the project will deliver new insights into the dynamics of losers' consent and its importance for democratic resilience and stability.

Keywords: losers consent legitimacy elections public opinion political behavior democratic crisis
Advancing Circular Economy Adoption in EU's PAs: A Realist Evaluation and Evidence-Informed Approach (CircTourEU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-17
End date: 2028-06-16
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

The CircTourEU project addresses pressing environmental challenges in the protected areas (PAs) in EU by applying Circular Economy (CE) principles to tourism. CE promotes resource reuse and sustainability, vital for combatting overtourism, greenhouse gas emissions, and biodiversity decline. Rural regions heavily dependent on tourism face these challenges and require innovative resource management and governance. The Southern Mediterranean hosts many European PAs, facing tourism surges. To protect these habitats, a systematic shift to CE involving small and medium enterprises (SMEs) is crucial. Yet, SMEs in EU tourism lack research and innovation focus, necessitating rural research and innovation pilots. Led by Dr Ante Mandić, supervised by Prof Xavier Font and Dr James Kennell, the CircTourEU project evaluates CE transition projects for tourism SMEs in the EU. It tests innovative methods in pilot PAs in Spain, Italy, Croatia, and Greece to promote evidence-based CE practices in the tourism industry. CircTourEU's innovation lies in using complexity science-based realist evaluation to understand barriers to innovation and knowledge integration in PAs. This approach offers nuanced insights into intervention effectiveness. The project recognises the importance of macro-level sustainability transitions and empowering rural SMEs with innovative CE business models. It considers context-dependent barriers and tailors strategies to unique PA governance and management contexts. CircTourEU aims to empower PA authorities for evidence-based CE transitions and disseminate knowledge for widespread implementation. Following the EU's "evaluation first" principle contributes to evidence-based decision-making, aligning with the European Green Deal and Circular Economy Action Plan. The project provides valuable lessons for balancing conservation and economic interests in European PAs.

Keywords: circular economy protected areas nature based tourism tourism sustainable tourism development complexity science realist evaluation evidence informed policymaking rural regions
First-in-kind anticancer therapy combining light-controllable cytotoxic peptides and dendritic cell-based immunotherapy (LIGHTHER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ukraine,Germany,Netherlands
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 925418.57
EU funding (EUR): 796590.0
Participants: 6
Project status: SIGNED

Project LIGHTHER (LIGHt-boosted THERapy) focuses on basic studies and early preclinical development of a groundbreaking therapy for one of the deadliest human diseases - lung cancer. The therapy includes in-patient activation of the immune system by light-controllable cytotoxic peptides, ex vivo loading of the patient’s dendritic cells (DCs) with exosomes or cancer cell lysates obtained using the same peptides, and treatment of the patients with the loaded DCs. Optimisation of efficacy and safety planned as the main outcome of the Project will pave the way for future preclinical and clinical studies of a radically novel, photosensitive drug. The main impact of the LIGHTHER Project in the long run will be creating a market segment for photopharmacology-based therapies. The participating institutions are complementary in their expertise, which will be transferred between them through secondments, research, and training. Lumobiotics, a small and medium enterprise (SME) with experience in drug development, will coordinate the work; Karlsruhe Institute of Technology and Taras Shevchenko National University of Kyiv will focus on the preparation and analysis of the peptides; National Cancer Institute of Ukraine will contribute its expertise in DC-based immunotherapy; SME Bienta and Amsterdam University Medical Center will do the in vitro and in vivo preclinical research. Six work packages are planned: 1) investigation of the immunogenic potential of light-controllable peptides; 2) evaluation of safety of the treatment by light-controllable peptides; 3) study of the DC activation by cancer cells treated by light-controllable peptides; 4) in vivo testing of the combination therapy on a lung cancer rodent model; 5) synthesis, laboratory scale peptide production, and analytics; 6) communication, dissemination, and management. The participating institutions will collaborate toward advancing the therapy to clinical applications, during the Project and after its completion.

Keywords: photopharmacology,light controllable cytolytic peptides,immunotherapy,dendritic cell based vaccination
Imaging data and services for aquatic science (iMagine)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: Research and Innovation actions
Countries involved: Netherlands,Türkiye,Greece,Spain,France,Italy,Belgium,Germany,Portugal,Ireland,Slovakia
Call: Enabling research infrastructure services for better use of imaging data to address challenges in thematic research areas (HORIZON-INFRA-2021-SERV-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 4500000.0
EU funding (EUR): 4500000.0
Participants: 25
Project status: SIGNED

iMagine provides a portfolio of free at the point of use image datasets, high-performance image analysis tools empowered with Artificial Intelligence (AI), and Best Practice documents for scientific image analysis. These services and materials enable better and more efficient processing and analysis of imaging data in marine and freshwater research, accelerating our scientific insights about processes and measures relevant for healthy oceans, seas, coastal and inland waters. By building on the computing platform of the European Open Science Cloud (EOSC) the project delivers a generic framework for AI model development, training, and deployment, which can be adopted by researchers for refining their AI-based applications for water pollution mitigation, biodiversity and ecosystem studies, climate change analysis and beach monitoring, but also for developing and optimising other AI-based applications in this field. The iMagine compute layer consists of providers from the pan-European EGI federation infrastructure, collectively offering over 132,000 GPU-hours, 6,000,000 CPU-hours and 1500 TB-month for image hosting and processing. The iMagine AI framework offers neural networks, parallel post-processing of very large data, and analysis of massive online data streams in distributed environments. 13 RIs will share over 9 million images and 8 AI-powered applications through the framework. Having representatives so many RIs and IT experts, developing a portfolio of eye-catching image processing services together will also give rise to Best Practices. The synergies between aquatic use cases will lead to common solutions in data management, quality control, performance, integration, provenance, and FAIRness, contributing to harmonisation across RIs and providing input for the iMagine Best Practice guidelines. The project results will be integrated into and will bring important contributions from RIs and e-infrastructures to EOSC and AI4EU.

Keywords: marine freshwater e infrastructure
Women Tech EU x CTD AS (Woman Tech EU)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Norway
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-02-28
Duration (months): 9.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Primary objectives are market mapping and scaling growth related to our business plan. It is highly relevant to implement these in our strategic planning and development from an early stage to assess our market opportunity at a fast pace. Secondary objectives are preparing our business for expansion through insight into public procurement and employment. Up until today we have gained information on the market situation for VR training in Norway, and characteristics that are important to take into consideration in our country. However, we are focusing on developing VR-training on international standardized procedures, confirming a great potential for our solution outside of the country. In order to succeed, we need to dedicate resources to execute an analysis of the international market. In particular, we need to conduct a competitor landscape analysis in the field. This includes addressing suppliers of medical training in VR and suppliers of e-learning for procedural training. Additionally, we need to address which markets will be our primary objectives for future expansion. These will be addressed by conducting a target market analysis and industry overview. We thereafter need to get insight and knowledge on the purchase process for our primary objectives, besides building the foundation for our employment. Women TechEU can help our business growth strategy both through mentorship and financing. We would benefit from having a mentor with experience from working with business in a fast-paced growth environment. Furthermore, we would benefit if the mentor had worked with MedTech and/or internationalization. It would be valuable for us to have a mentor that could play an active role in helping us improve our starting point related to facing the demanding and time-consuming purchase process. Included in this, is having mentorship to help us evaluate and strengthen our foundation for building a high-performance team.

Keywords: growth strategy education health medical and health care public sector technology sustainability healthtech medtech software virtual reality clinical trials in development
Single cell RNA-seq analysis of individual sperm cells to identify transcriptomic differences potentially involved in preferential fertilization. (SAMEorNOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-09-30
Duration (months): 21.0
Total project cost (EUR): 137181.24
EU funding (EUR): 137181.24
Participants: 1
Project status: CLOSED

Human societies are sustained by flowering plants in different ways but especially as a key food supplier. However, it is known that increasing global temperatures strongly affect plant reproduction and the growing human population will require more food in short-middle term. Thus, to create new crop varieties more resistant to heat stress and with enhanced yield, a deeper understanding of the mechanism of plant sexual reproduction will be crucial for increasing the efficiency of plant breeding programs. Plant reproduction relies on a double fertilization process, in which two sperm cells from a pollen grain reach the ovule and one fertilize the egg cell while the other the central cell. In some species with dimorphic sperm cells a preferential fertilization of each sperm cell has been described, but for Arabidopsis thaliana as well as for many economically important crops with isomorphic sperm cells this question remains unclear. The main goal of this project is to identify by single cell RNA-seq analysis potential transcriptomic differences between the two Arabidopsis sperm cells. To do that, individual sperm cells from pollen tubes growing through female stylar transmitting tissue (semi in vivo) will be isolated by micromanipulation using a specially designed microfluidic chamber on an inverted microscope. The identification of differentially expressed genes would enable for the first time the creation of a sperm single-cell marker line to eventually explore a hypothetical preferential fertilization in Arabidopsis. These results can be adapted for plant breeding programs to develop impactful biotechnological tools, like haploid inducer lines with genetically modified sperm cells to specifically deliver components in the egg cell to induce in vivo gynogenesis. Additionally, the results will be a valuable scientific resource to address other topics beyond the preferential fertilization, like exploring hybridization barriers based on gamete recognition.

Keywords: plant reproduction,pollen,sperm cells