Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dopamine and Bone Metabolism in Rheumatoid Arthritis (DeBoRA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Rheumatoid arthritis (RA) is associated with local bone erosion and systemic osteoporosis, which leads to severe disability and low quality of life. Although treatment with biologics can reduce bone loss by inhibiting inflammation, biologics are not able to achieve bone repair and some patients do not respond sufficiently to the treatment. Therefore, an efficient long-term therapeutic approach to target bone erosion and osteopenia still need to be established. Here, we describe a possible involvement of the neurotransmitter dopamine (DA) in bone metabolism and how we aim to use this new pathway to control bone erosion and restore bone mass in RA. The involvement of DA on joint inflammation in RA was demonstrated in vitro and in vivo, and an elevated concentration of DA in the synovial fluid of RA patients was also described. Moreover, we recently described that DA is produced in RA synovial tissue and can act in an autocrine/paracrine manner. However, it is still unclear which role local DA can exert on bone erosion in RA. We performed preliminary experiments and could confirm the presence of DRs in RA bone remodeling zone and in osteoblasts isolated from RA. Moreover, DR activation stimulated IL-6. This confirms the active role of local DA also on bone metabolism in RA. Goal of the present study is therefore to elucidate the mechanisms of action of DA in bone remodeling in RA, in order to find out how to modulate this pathway to control bone erosion and stimulate bone formation in RA. Specifically, we will address the following issues: 1) To identify the mechanisms responsible for DRs expression in RA bone remodeling zone, 2) To define mechanisms of action of DRs on bone metabolism in the context of RA 3) To prove the clinical applicability of DA modulation in arthritic joints towards an anti-inflammatory and bone-protective path. Final goal of this project is to establish a new therapeutic approach to block bone erosion and restore bone mass in RA.

Keywords: rheumatoid arthritis,dopamine,bone remodeling,osteoblasts
MUlti-cloud Secure Applications (MUSA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Finland,Poland,France,United Kingdom,United Kingdom
Call: Advanced Cloud Infrastructures and Services (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3574190.0
EU funding (EUR): 3574190.0
Participants: 11
Project status: CLOSED

The most challenging applications in heterogeneous cloud ecosystems are those that are able to maximise the benefits of the combination of the cloud resources in use: multi-cloud applications. They have to deal with the security of the individual components as well as with the overall application security including the communications and the data flow between the components. The main objective of MUSA is to support the security-intelligent lifecycle management of distributed applications over heterogeneous cloud resources, through a security framework that includes: security-by-design mechanisms to allow application self-protection at runtime, and methods and tools for the integrated security assurance in both the engineering and operation of multi-cloud applications. The MUSA framework leverages security-by-design, agile and DevOps approaches in multi-cloud applications, and enables the security-aware development and operation of multi-cloud applications. The framework will be composed of a) an IDE for creating the multi-cloud application taking into account its security requirements together with functional and business requirements, b) a set of security mechanisms embedded in the multi-cloud application components for self-protection, c) an automated deployment environment that, based on an intelligent decision support system, will allow for the dynamic distribution of the components according to security needs, and d) a security assurance platform in form of a SaaS that will support multi-cloud application runtime security control and transparency to increase user trust. The project will demonstrate and evaluate the economic viability and practical usability of the MUSA framework in highly relevant industrial applications representative of multi-cloud application development potential in Europe. The project duration will be 36 months, with an overall budget of 3,574,190 euros.

Keywords: cloud security,multi cloud,distributed application,heterogeneous cloud,security sla,decision support,deployment,monitoring,enforcement,security assurance,devops,lifecycle management
Wearable sensors and actuators to monitor and promote physical and emotional wellbeing (BEWELL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Germany,Germany,Finland,Belgium,Finland,France
Call: Flexible and Wearable Electronics (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-03-31
Duration (months): 39.0
Total project cost (EUR): 4164845.0
EU funding (EUR): 4164845.0
Participants: 9
Project status: CLOSED

BEWELL project is about developing integration and manufacturing technologies needed for smart skin patch and wrist-device wearable electronics sensing and actuating products. BEWELL project is also about demonstrating three different application use cases. Wearable electronics belongs to new age consumer electronics together with smartphones, gaming consoles and laptop/tablet computers. Key development focuses of the new devices are better human-machine interfaces, improved connectivity, user-friendly form factors and convenience of use. Internet of things, connected living, quantified self and smart homes are identified as the driving trends of this evolution among which especially the quantified self is clearly driving the wearable electronics. Inside wearable electronics, wrist-worn devices have been the largest segment but body-worn and head-worn devices are expected to grow to similar sized segments. Intimate skin contact is necessary for reliable sensing and actuation based on sensor results during different levels of activity of the users. Controllable skin contact would be a further improvement in sensing applications. The purpose can be to replace or supplement visual messaging. Therefore, skin patches and associated technologies to enhance the user-device interface also in other types of products such as the wrist-worn ones are of special importance. In BEWELL, we have identified commercially relevant future skin-patch products to be demonstrated. We have also identified a set of critical and versatile technologies that need to be developed for scalable manufacturing and integrated to realize these future products. In particular, the BEWELL project aims to unleash the potential of flexible and wearable electronics for physical and emotional wellbeing by advanced integrated technology components made in Europe.

Keywords: biosensors,haptics,wearable skin patch,wrist worn technologies
GEOarchaeology of DAily Practices: extracting bronze age lifeways from the domestic stratigraphic record (GEODAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy,Italy,Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1987141.0
EU funding (EUR): 1862141.0
Participants: 3
Project status: SIGNED

What was daily life like in the European Bronze Age? In contrast to large-scale narratives based on artefacts, often prestige items from funerary contexts, this project focuses on the practices of daily domestic life, recorded in the sediments upon which it took place. These constitute the domestic stratigraphic record. This project, therefore, shifts the scale and the object of archaeological investigation, and aims at bringing interdisciplinary scientific analyses into dialogue with anthropological understandings of lifeways and households. Its main objective is the formulation of an innovative narrative of the Bronze Age addressing social, economic, and environmental aspects of a culturally interconnected region of Europe. The daily practices and life histories of bronze age people will be the pixels of this new picture that challenges previous depersonalized narratives relying on material culture. The region between the Carpatho-Danubian basin, the Balkans, and northern Italy was selected due to its important cultural interactions during the Bronze Age. Ten key archaeological sites in six European countries constitute the project’s database. Its innovative interdisciplinary approach integrates geoarchaeology (micro-stratigraphic analysis), organic chemistry (biomarkers) and archaeo-botany (phytoliths, seeds, fruits, and charcoal) to reconstruct with unprecedented accuracy the daily practices from domestic stratigraphy. This information will be compared with the story told by material culture and integrated with local paleo-environmental records. The project, in fact, challenges also previous reconstructions that called in environmental mega-events (volcanic eruptions, glacial advances, aridity events) to aprioristically explain broad cultural phenomena of the Bronze Age. Their inherent complexity can only be faced by crystallizing detailed micro-histories and site-specific environmental reconstructions into a broader synthesis based on hard scientific data.

Keywords: geoarchaeology,bronze age europe,paleo environment,soil micromorphology,household archaeology
Quantifying the structure-function of the neurovascular interface: from micro-circuits to large-scale functional organization (MultiScaleNeurovasc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2021-05-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Neuronal computations in the brain require a high metabolic budget yet the brain has extremely limited resources; calling for an on-demand, robust supply system to deliver nutrients to active regions. In most cases, neuronal activity results in an increase in blood flow to the active area, a phenomenon called functional hyperaemia. This coupling between neuronal and vascular activtuy underpins the mechanism enabling fMRI to map neuronal activity based on vascular dynamics; further, malfunction of the cellular players involved in coupling is now considered to play a key role in otherwise classically defined neurodegenerative diseases. We lack a concise description of the inner workings of this mechanism and a thorough quantitative description of the neuro-gila-vascular interface; issues that are best addressed by an investigation into the cellular mechanisms, the temporal dynamics and multi-scale spatial organization governing neurovascular coupling. My long-term goal is to provide a unified theory to encapsulate our knowledge on neurovascular coupling. Here, I hypothesize that functional hyperaemia results from the constant integration of vasoactive cues with region-dependent coupling emerging from different neuro-glia-vascular microcircuits, nuances in afferent wiring into vascular contractile elements and/or neuronal activity patterns. I will test this hypothesis with a multi-faceted correlative approach combining: two-photon awake imaging of cellular and vascular dynamics to obtain physiological data unaffected by anaesthetics; super-resolution structural imaging of intact volumes to map the fine details of micro-circuit structure; array-tomography to map in situ the neurovascular signalling machinery and novel optogenic tools to manipulate several of its specific components. I expect to offer a revolutionary mechanistic insight into one of the most basic and fundamental physiological processes behind the structure and function of the brain.

Keywords: layer dependent neurovascular coupling,two photon awake imaging,interneurons,pericytes,astrocytes,micro circuit,array tomography,large scale mapping,optical cleared tissue,function structure
Superslippery Liquid-Repellent Surfaces (SuperRepel)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 1999467.64
EU funding (EUR): 1999467.64
Participants: 1
Project status: CLOSED

I aim to progress substantially the understanding and applications of extremely non-wetting surfaces, tying together basic research and attractive technological advancements. The first part focuses on robust synthesis methods for superslippery liquid-repellent (SS-LR) surfaces. Furthermore, using new types of ultrasensitive force measurement for droplets, I will investigate in depth the dissipation dynamics of mobile water droplets and adhesion of droplets to surfaces, to promote understanding on low-friction surfaces. The second part aims at applying these SS-LR surfaces in droplet actuation with potential to outperform existing technologies. Additionally, the potential of SS-LR surfaces for anti-icing and for preventing bio-fouling will be investigated. The research results will have a major impact on liquid-repellent technology and will explore the fundamental physical limits of non-wetting.

Keywords: superhydrophobic surfaces,low friction surfaces,water droplets
do Maths Outcomes Reflect Expertise Linked to Effective Strategy Selection? Event related brain potentials and eye movement studies in children and adults (MORE-or-LESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Excellence in Science, Technology and Engineering (STEM) subjects are crucial to the development and wellbeing of both societies and individuals. Mathematics lies at the heart of all STEM subjects. Contrary to its importance, to date not much is known about advanced levels of mathematical development. This project aims to remedy this situation by providing an innovative study investigating strategies that both children and adults use to solve arithmetical problems and integrating competences derived from psychological and mathematical educational domains. Consequently, the outcomes of this research can easily be drawn into concrete implications: effective teaching of maths strategies, applicable both in the educational and in the clinical field, will not only help children and adults struggling with maths but will also facilitate the learning of maths among average or even excellent students. Specifically, the MORE-or-LESS project aims to analyse: the strategies used by both children and adults to solve complex mental addition and subtraction problems; the effects of problem features, such as the complexity of the operation (i.e., number of digits), or the presence/absence of carry/borrow procedures, and the type of representation (i.e., Arabic digits, number words, dot patterns); the specific role of working memory in mental calculation; and the psycho-physiological data related to arithmetical processing. The project fills an important gap because, so far, most research exploring the relationship between strategy selection, cognitive processes and mental arithmetic has focused on adults’ simple calculation. The project is highly innovative as it integrates different experimental methods: both behavioural and psycho-physiological data will be collected. Through this project the candidate will be trained in the application and analysis of eye movement tracking and event-related brain potential techniques both of which will equip her with new skills and knowledge.

Keywords: math strategies,working memory,eye movements,event related brain potentials erps
Post-transcriptional regulation of effector function in T cells by RNA binding proteins (PRinTERs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

CD8+ T cells are critical to fight infections and to clear tumor cells through the production of inflammatory cytokines and cytotoxic molecules. These effector molecules must be tightly controlled: too little leads to the inability to control the pathogen, and too much can result in a life-threatening cytokine storm and tissue damage. While transcriptional control of effector genes is well-studied, regulation at the levels of RNA stability and translation efficiency by RNA-binding proteins (RBPs) has remained underappreciated. We recently found that several cytokines are tightly regulated through these processes, and we identified ZFP36L2 as one of the responsible RBPs. However, much is still to be learned about the underlying molecular mechanisms. Moreover, there are >1000 putative RBPs, and a systematic analysis of their regulatory activity in T cells is lacking, particularly with regard to the control of effector proteins. Here, we will use a combination of mouse genetics, and molecular and cellular biology to gain a deep understanding of the control of cytokine production by RBPs, using ZFP36L2 as a paradigm. Next, we will take a novel, highly sensitive proteomics approach to systematically identify the RBP repertoire in resting and activated primary human T cells. Complementary functional screens will identify those RBPs that control specific effectors. Selected RBPs identified in these screens will be studied in-depth to understand their roles in T cell responses to acute infection and in tumor models. Lastly, we will define how RBPs can imprint and/or maintain the killer phenotype of human CD8+ T cells. This research will significantly advance our understanding of post-transcriptional regulation of T cell effector activity, and it should help us to develop novel tools to drive effective T cell responses against pathogens and malignant cells.
A new manufacturing method, monitoring platform and material equipment to carry out a more efficient production of plastic bottles, reducing its waste. (PET-Yield)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Ireland
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The plastic Polyethylene Terephthalate (PET) is one of the most used non-biodegradable materials on the planet. In 2010, demand was 12,621,553 tonnes and it is forecast to grow to 23,452,287 tonnes by 2020. This continuous annual growth highlights a devastating problem facing all of humanity. In addition to this increase in the consumption of plastic, and the difficulties of plastic disposal, there is an incapability of plastic manufacturing companies to control the production adequately. In fact, they endure the instability inherently caused by PET raw material variation, the resulting scrap rates, and the low possibility to use recycled material. ACCUCOLOUR reduces these impacts with “PET Plastic Yield”, an advanced product composed of new materials and a new manufacturing process, equipped with constant monitoring. PET Yield enables plastic packaging manufacturers: a higher efficiency in the entire manufacturing process; a 4% reduction in scrap rates, and an increased potential for use of recycled material between 50% (in food packaging) and 100%. Increasing the use of recycled PET and decreasing scrap rates, ACCUCOLOUR will have a substantial impact on the health of the environment, especially on the marine ecosystem in Europe. Further, over 30 positions will be created at ACCUCOLOUR alone, not including indirect growth for customers. ACCUCOLOUR's role in the market will be very strong as it will be physically close to the main potential clients in order to foster face-to-face relationships. During the Phase 1 feasibility study the project will focus on identifying and securing the key partners required for commercialisation, establishing a sound business model and commercialization strategy.

Keywords: plastic,plastic bottles,pet polyethylene terephthalate,plastic scrap rates,reduce plastic,waste,recycled plastic