Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Turning soils into stone (BioPetrify)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Stabilising the soil around us is paramount to our own safety within our homes and surroundings. Today, the most effective and reliable soil stabilisation methods (cement and chemical additives) are expensive and harmful to the environment. Cement production alone represents 5% of all global human-created CO2 emissions. The market for soil stabilisation hasn’t been disrupted in decades, with toxic industrial fluids such as acrylamide, and heavy equipment still required for manufacture and application. It is widely agreed that new technologies are desperately needed to reduce CO2 emissions of the cement industry by 70% by 2050 as well as to eliminate the use of toxic chemicals from soil stabilisation applications. Our innovation, BioPetrify, offers a natural soil stabilisation solution for use in both new and repair construction projects. BioPetrify offers the first liquid agent able to turn soil into stone, harnessing the power of a harmless microorganism in an industrially scalable way, to achieve compressive strength of conventional construction materials, sustainably. No heavy machinery needed, no CO2 released. BioPetrify is readily integrable into existing construction processes and time-scales and tailorable to each unique soil and construction type. Application is even possible under existing structures, where it is 10x cheaper than existing solutions. BioPetrify not only represents the solution to the environmental and physical limitations of current stabilisation methods, but offers a lever for market expansion of current stabilisation material providers (e.g. adding strength to geotextile), with whom we are already partnering. Our primary target customers will thus be European market-leading construction companies. With the potential to displace today’s polluting soil stabilisation methods (a €24.7 billion market), we expect to grow quickly, selling 400,000 tonnes of our product and creating more than 100 new jobs already by 2026.

Keywords: environment,pollution and climate
High ThRoughput lasEr texturing of Self-CLEANing and antibacterial surfaces (TresClean)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Spain,Italy,Germany,Italy,France,United Kingdom,United Kingdom
Call: Photonics KET (H2020-ICT-2015, 2015)
Start date: 2016-04-01
End date: 2020-09-30
Duration (months): 54.0
Total project cost (EUR): 3363091.25
EU funding (EUR): 3363091.25
Participants: 9
Project status: CLOSED

The TresClean project will develop high-throughput laser-based texturing for fluid-repellent and antibacterial metal surfaces using innovative industrial high-average power ultrashort-pulsed lasers in combination with high-performance scanning heads. These technologies will be applied to produce self-cleaning and aseptic machine parts for food industry (e.g. components in contact with biological fluids) and home appliances (e.g. dishwashers) by utilising a beam delivery method over areas that can reach 250 mm2. In the first phase of the project the basic research activities for the surface design will be implemented together with a subsequent robust and scalable processing technologies and the development of the required laser sources and scanning systems. With the purpose of meeting the end users’ requirements all the activities included in the first phase will be defined in detail in accordance to the predefined physical limits of the system technology. The design of surface structures and definition of the characterization methods will inform the subsequent work on two different technologies (DLIP and LIPSS) for the production of the needed structures, with respect to the process robustness and the scalability. In the second phase the technologies developed will be up scaled to a high throughput production of functional surfaces. The laser systems and high speed scanning unit will be combined. Work on the upscaling of the processes on simplified geometries (2D) and development of processing strategies for the defined demonstrative parts will be performed. Then the final demonstration, the testing of the added functionality and the high throughput production will be done on the defined parts from the end-users in the last phase of the project
Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation (MECSPEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-07-01
End date: 2022-06-30
Duration (months): 60.0
Total project cost (EUR): 2306862.0
EU funding (EUR): 2306862.0
Participants: 1
Project status: CLOSED

Embryogenesis is achieved by the close interplay between the gene regulatory networks that control cell fate specification and the physical processes by which the embryo takes shape. While each of these systems has been extensively investigated over the past decades, comparably little is yet known about how they functionally interact across different scales of organization within the physiological context of the developing embryo. The central aim of this proposal is to elucidate the fundamental principles underlying the interaction and feedback between cell mechanics and fate specification during vertebrate gastrulation. Using zebrafish as a vertebrate model organism, we will explore how germ layer progenitor cell fate specification affects the physical processes by which the gastrula takes shape, and, vice versa, how alterations in cell/tissue mechanics feed back onto the gene regulatory networks and signals controlling progenitor cell fate specification during gastrulation. To dissect the fundamental mechanisms underlying this crosstalk, we will combine genetic, cell biological and biophysical experimentation with mathematical modeling. We expect that this transdisciplinary approach will provide answers to a central yet unresolved question in developmental biology: how the interplay between cell mechanics, dynamics and fate specification drives embryo morphogenesis and patterning.

Keywords: cell biology,signal transduction,organogenesis,developmental genetics,pattern formation in plants and animals,stem cell biology
Fire Impacts in Rainforest Ecotones (FIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Amazonian rainforest ecotones (AREs) are one of the most heavily exploited and most threatened ecosystems in the Amazon. Fire plays an integral role in maintaining these vegetation transition zones from fire-averse rainforest to fire-prone savanna vegetation. Synergies between direct human activity and indirect climate change impacts threaten to accelerate forest transformation through positive feedback loops by increasing future fire susceptibility, fuel loads and fire intensity. As regional precipitation is expected to decrease due to deforestation and reduced evapotranspiration, and natural- and human-caused ignitions are projected to increase fire in AREs. The combined results will likely drive the expansion of savanna forests at the expense of the rainforest vegetation. AREs have largely been neglected in fire management strategies and the long-term ecological effects of fire in AREs remain poorly understood. Therefore, there is an urgent need to understand the long-term effects of climate variability and human disturbance on fire in these vital ecosystems to inform future land-management and conservation efforts. The objective of this proposal is to determine the natural and human-caused drivers of fire in the Bolivian ARE for the past 8,000 years. I have thus developed a state-of-the-art interdisciplinary framework integrating high-quality palaeoecological, palaeoclimatological data with current archaeological survey data to provide long-term records of natural variability and human land-use change. These new data will be incorporated into various scenarios in statistical Structural Equation Models to investigate natural and human factors driving fire in AREs for the past 8 thousand years. I will develop a case study for proof-of-concept of a new interdisciplinary framework that will result in a greater understanding of the long-term drivers of fire in AREs and inform how future climate and changes in land-use practices may impact these vital ecosystems.

Keywords: bolivian amazon,fire,macrocharcoal,rainforest,ecotone,savanna,paleofire,structural equation modeling,archaeology,disturbance,pre columbian,deterium,leaf wax isotopes,paleohydrology
Going global? Renewable fuel trade and social land-use restrictions in a low-carbon energy system (reFUEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Austria
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-08-01
End date: 2024-01-31
Duration (months): 66.0
Total project cost (EUR): 1499905.0
EU funding (EUR): 1499905.0
Participants: 1
Project status: SIGNED

Recent global integrated modelling studies indicate low intensities in trade of energy commodities between global regions in a future low-carbon global energy system. Also, research based on modelling indicates that deep greenhouse-gas emission cuts are possible in fully electrified renewable energy systems on a continental or country scale from a techno-economic perspective. However, these modelling efforts partly neglect drivers of globalization and may therefore wrongly project regionalization of energy systems. In particular, (i) new, easily tradable, low-cost renewable fuels (e.g. solar & electric fuels), (ii) global bio-physical variability of renewables (e.g. solar radiation and freshwater availability), and (iii) regional differences in social land-use restrictions associated with the expansion of energy infrastructure can cause an increase of trade flows in the energy sector. We aim at better understanding how the spatial configuration of renewables in low-carbon energy systems is affected by these drivers and develop a cutting-edge, open-source global renewable energy model that combines elements of energy system and land-use modelling. It takes into account bio-physical conditions for renewable fuel and electricity production, social land availability restrictions, and a map of existing energy infrastructure at unprecedented level of detail. Our approach integrates open data sources from public institutions, user-generated GIS data, and social networks. Existing models for Europe and Brazil are used for validation. Qualitative interviews in local case studies complement the global model and increase our understanding of land-use restrictions on the local scale. Our project has impacts beyond energy systems analysis: in particular the identification of winning and losing regions in a global renewable energy system is highly relevant in climate change mitigation negotiations, and the generated spatial indicators and maps enable many potential applications.

Keywords: energy system analysis,solar fuels,qualitative validation,renewable energies,trade
ChemArch: The organic chemistry and molecular biology of archaeological artefacts (ChemArch)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,France,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 4236454.44
EU funding (EUR): 4236454.4399999995
Participants: 4
Project status: SIGNED

We propose a European Joint Doctorate in response to the need for early stage training between the analytical sciences and archaeology. Archaeological chemistry, biomolecular archaeology and archaeometry are fast growing disciplines that have reinvigorated research of museum and archaeological artefacts. These approaches now offer forensic detail regarding the origin, manufacture and use of iconic and everyday items in the past. Articles published in the last year alone, such as the extraction of human genomes from Stone Age ‘chewing gum’, the fashioning of prehistoric hunting weapons from human remains, and the identification of milk in ancient ceramic infant feeding bottles, show how this field continues to influence a range of scholars, change curatorial practice and capture the attention of the global public. However, recruiting researchers with the necessary interdisciplinary skills to meet the rapid expansion of the field has been difficult. To address this challenge ChemArch will: - Support the career development and training of 15 doctoral students crossing the sectoral divide between the natural and analytical sciences and social sciences. - Create a network of European specialist labs with complementary expertise and wordwide reach. - Link these specialised labs with non-academic research organisations, analytical instrument manufacturers, museums and field work units. - Provide coherent training around a thematic program converging on advancing our understanding of Europe’s rich prehistoric artefact record. - Involve leading organisations with a sustained history of delivering world-leading interdisciplinary science/humanities training at doctoral level. - Provide a durable legacy through the joint creation of guidelines for best practice in the field and the lab and tools to help predict where future research efforts are best directed. - Engage the public through outreach events, a set of Wikipedia entries and educational videocasts.

Keywords: artefact,archaeology,archaeological science,palaeogenetics,organic residue analysis
COMmunication and Assessment With Adaptive Realtime Environments (COMAWARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Austria
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our overall objective is to provide both new brain-computer interface (BCI) technologies and an innovative business model focused on user-centered assessment and communication for persons with disorders of consciousness (DOCs). We have recently shown that present clinical tools to assess DOC are inadequate. Across different studies, up to 43% of patients who had been designated as nonresponsive (including in a vegetative state (VS) or minimally conscious state (MCS) were in fact able to communicate through new BCI systems developed for such patients. For example, patients could produce reliable changes in motor activity in the EEG when asked via headphones to imagine left hand movement or walking through the house if their father was named (the correct name). In related work, patients could produce differential responses to YES/NO/SKIP questions (based on the P300 component) by counting vibrations of one out of three different tactors placed on the body. This creates a pressing social and economic challenge to provide more accurate information about these patients’ cognitive abilities to families, clinicians and the patients themselves about their long-term options. By providing BCI-based assistive technology (AT) for communication and control, we will allow patients to not only make their own decisions but also interact with their environments, the internet and other people, fostering inclusion and accessibility. The main outcome will be a life-changing experience for many patients: being recognized as someone who can communicate. They will once again be able to convey their needs and desires to carers, and may influence decisions about therapy, end-of-life, living environments, long term care and use of ComAware products and services. Carers and medical staff will be able to better identify patients’ needs and provide care and help accordingly. Family and friends will again be able to communicate with someone they had been (mistakenly) told could not communicate.

Keywords: brain computer interface,disorders of consciousness
Developing and implementation of a new generation of nanosafety assessment tools (NANOGENTOOLS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Austria,Spain,Cyprus,Belgium,Greece,Romania,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 706500.0
EU funding (EUR): 706500.0
Participants: 8
Project status: CLOSED

NanoMaterials safety is of great societal concern and raises many questions for the general public, governments, industry, scientists and regulators. Identifying and controlling the hazards associated with NMs is required to ensure the safety in parallel to exploiting the technological benefits. NANOGENTOOLS answers this challenge by creating a collaborative excellence-based knowledge exchange network that will: i) push forward knowledge via method development and pre-validation, ii) train scientists in new methodologies to assess long term nanosafety, and iii) support their inclusion in standardization and EU regulations. NANOGENTOOLS combines toxicogenomics, proteomics, biophysics, molecular modeling, chemistry, bio/chemoinformatics to develop fast in vitro high throughput (HTS) assays, with molecular based computational models for nanotoxicity. Its objectives are to: · Provide solutions for faster, more reliable assessment of NM toxicity and propose HTS and omics tools for predicting toxicological properties of NMs. · Develop new bioinformatics methodologies for analyzing -omics data and create an open database in collaboration with the EU Nanosafety Cluster. · Conduct research and training on biophysical techniques and mathematical models for accurate and fast nanotoxicity prediction. · Build/improve the safe by design concept, demonstrated using carbon-NMs and nanosensors. · Place our new knowledge in the context of regulations and EU roadmaps. NANOGENTOOLS brings together cutting edge research, innovative knowledge-transfer and co-development, and cross-sectoral and cross-disciplinary secondments linking EU academic institutes/networks with industry and policy makers across 8 countries. Expected impacts include pre-validated tools for efficient cost-effective nanosafety assessment applicable to SMEs for incorporation into regulatory frameworks, and translation of knowledge via development of a CNT-based nanosensor based on safe-by-design principles.

Keywords: nanosafety,nanotoxicity,biophysics,bioinformatics,genotoxicity,genome,policy,regulations
The molecular basis of NleB-mediated bacterial virulence (BATTLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-04
End date: 2018-01-03
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Bacterial pathogens have evolved distinct ways of colonizing host cells and promote infection. Many human intestinal bacterial pathogens such as Salmonella, Shigella and enteropathogenic/ enterohemorrhagic Escherichia coli utilize type III secretion systems to deliver virulence effector proteins into the host to promote colonization and interfere with antimicrobial host response. Among the type III effectors, the NleB protein has been shown to be essential for virulence of enteric pathogens. NleB is a glycosyltransferase that has been shown to interact with host cell death-domain-containing proteins, GlcNAcylate a specific arginine on these and thereby inhibiting death receptor signalling and preventing host cell apoptosis. This proposal will 1) investigate how NleB specifically recognises the host death domains, 2) uncover the molecular mechanisms of arginine GlcNAcylation, 3) explain how death domain GlcNAcylation prevents the death domain from binding to its receptor, and 4) exploit this molecular information to generate bisubstrate inhibitors to interfere with this process.

Keywords: bacterial virulence,arginine glcnacylation,apoptosis,signalling