Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Empowering participation and accelerating synergies in Widening countries with a focus on Green & Digital Transition (TWIN SYNERGIES)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Economic Sciences
Countries involved: Slovenia,Romania,Czechia,Croatia,Germany
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 1199967.5
EU funding (EUR): 1199967.5
Participants: 9
Project status: SIGNED

There is a substantial differentiation in terms of R&I performance among the EU member states. This divide has also been reflected in differing levels of participation in the framework programmes, for which the allocation of funding is based on excellence. Low participation in turn limits the potential of under-performing countries to overcome the shortcomings in their R&I systems. In recent years, one of the main priorities of the European Commission was bringing Cohesion policy and Horizon 2020/Horizon Europe closer together with an aim of strengthening the impact of both policies by creating complementarities, especially in less developed and peripheral regions. Considering these facts, TWIN SYNERGIES project aims at supporting the EU strategic context in regard to creation of synergies at the operational and governance level, directing towards the Upstream synergies mode – Human resources development and Internationalisation. In this manner, especially Smart Specialization Strategies, essential instruments for creating combined effects with smart growth-related instruments at EU level (especially with HE) will be taken into consideration. TWIN SYNERGIES project, gathering 9 partners from 4 Widening countries and 1 EU Member State will in 24-month project duration develop and apply upstream compatible, tailor-made, but transferable activities for capacity building, internationalisation, HR development, collaboration, valorisation, and technology uptake, focusing on the current developments related to the Green and Digital transition. Besides, as essential part of upstream/downstream synergies, the project will put a strong focus improving the cooperation stage and communication corridors among the relevant actors – particularly the EU and national authorities involved in the programming and implementation of HE and ERDF support.

Keywords: synergy,capacity building,internationalisation,human resources development,green and digital transformation
Strict protection, restoration and co-management of Marine Protected Areas to ensure effective ecosystem conservation and improved connectivity of Blue Corridors (BLUE CONNECT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Germany,Belgium,Bulgaria,Norway,Netherlands,Spain,Estonia,Italy,Portugal,Romania,Finland,Cabo Verde,Croatia,United Kingdom
Call: European Blue Parks – Protection and restoration of marine habitats (HORIZON-MISS-2023-OCEAN-01, 2023)
Start date: 2024-09-02
End date: 2028-03-01
Duration (months): 42.0
Total project cost (EUR): 8469860.0
EU funding (EUR): 8375060.0
Participants: 25
Project status: SIGNED

The BLUE CONNECT project addresses the urgent need to protect and restore marine habitats and ecosystems and to reach ambitious EU and global protection and restoration targets by 2030. Together with Marine Protected Area (MPA) managers, authorities, industries, and local communities from 12 Demonstration sites and beyond, BLUE CONNECT is co-developing, promoting, and demonstrating a systematic approach to marine conservation planning and management. This collaborative effort will result in the creation of a powerful Blueprint, directly supporting 1) setting science-based conservation objectives, 2) co-defining conservation actions for effective MPA co-management, 3) ensuring conservation effectiveness and 4) demonstrating the high potential of these tools for replicability and broader use. This will be made possible by establishing a holistic modelling framework that integrates various elements of biodiversity, ecological functioning, ecosystem services, and connectivity, while also considering inputs from stakeholders and local communities regarding social, economic, and cultural aspects when defining MPAs and ecological corridors. The project will contribute to a more comprehensive, science-based and inclusive approach to designating new MPAs or expanding existing ones, transitioning to strict protection, restoring ecosystems, enhancing ecological connectivity, and facilitating MPA co-management. By fostering just and fair stakeholder cooperation and citizen science initiatives, BLUE CONNECT will build a greater feeling of co-ownership of protected and restored marine ecosystems and MPA networks and empower communities to play a crucial role in safeguarding our seas.

Keywords: ecological connectivity blue corridors mpa collaborative management
Female Leadership and Effects from African Droughts (Fem-LEAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499568.0
EU funding (EUR): 1499568.0
Participants: 1
Project status: SIGNED

Fem-LEAD challenges present scholarship by proposing a new link between climate change and gender: What if weather-related disasters, such as droughts, risk hurting recent advances of women as political leaders in African countries? Focusing on droughts, public opinion and political representation, its objective is to gain theoretical and empirical insights of links between weather-related disasters and women’s political standing. I pose two major questions; Q1. How and why do droughts affect the citizen demand for female politicians? Q2. How and why do droughts affect the supply of female candidates and the presence of elected women? I develop and test theoretical expectations in two directions; First, on citizens’ demand for female leaders (Q1). This vein is investigated through three rigorous methods: I analyze observational data where geocoded information on droughts is connected to survey respondents across Africa and over time. Exploring mechanisms, I focus on South African drought-affected communities, using in-depth interviews. To test causal mechanisms, I implement creative survey experiments with information treatments on droughts and candidate preferences. Second, I study the electoral arena (Q2). I focus on droughts and local elections across African countries and especially on South Africa, with a unique complete register of candidates and representatives across wards for two decades. I also interview party gatekeepers and, finally, look at aggregated trends across countries. I build on my long publication record and local network in the field. Having conducted pilot-studies, the inquiry of Q1 is feasible yet novel. Having access to high-quality data – that no one has analyzed – the study of Q2 promises groundbreaking findings. Fem-LEAD will result in a new theoretical framework and rich empirical insights. By investigating this link, I contribute with a new perspective to the literatures on gender, climate changes and electoral effects of disasters.

Keywords: gender climate change political representation
Supporting the next generation of African experts on preventing mortality among children living with HIV through a translational training. (SUPPORT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Spain,Italy,France,Netherlands,Mozambique,Uganda,Senegal,Zambia,United Kingdom,Zimbabwe
Call: Global Health EDCTP3 Training Networks - Clinical Research Fellowships (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2024-06-01
End date: 2028-11-30
Duration (months): 54.0
Total project cost (EUR): 5081593.75
EU funding (EUR): 5081593.75
Participants: 15
Project status: SIGNED

The SUPPORT project aims to strengthen health research systems in sub-Saharan African (SSA) countries affected by poverty-related pediatric infectious diseases. This goal will be achieved through a comprehensive fellowship program designed to train and mentor early and mid-career researchers. The consortium comprises clinical research institutions, academia, and stakeholders from both SSA and Europe. Makerere University in Uganda will act as the scientific leadership hub, with fellows stationed at leading SSA research institutions, fostering South-to-South collaboration. Additionally, short-term internships at European institutions will complement their training. The selection of target host countries, including Mozambique, Uganda, Zambia, Zimbabwe, and Senegal, was based on their research capacity needs and disease burden, encompassing Anglophone, Francophone, and Lusophone nations. The impact of SUPPORT will be the establishment of a competent and innovative community of scientists and healthcare professionals equipped to actively investigate and address pediatric infectious diseases, including epidemic management, in SSA. By strengthening research capacity and promoting collaboration, the project contributes to long-term improvements in morbidity and mortality associated with infectious diseases in children from low- and middle-income countries (LMICs). SUPPORT will train 8 early-career fellows and 5 mid-career fellows, developing a new collaborative clinical study based on two ongoing EDCTP projects, EMPIRICAL and UNIVERSAL. The fellows will undergo a rigorous training program that combines online and face-to-face components to develop essential research skills. This training will be integrated with their individual research projects, which address critical research questions related to pediatric infectious diseases in SSA. The fellows will take the lead on these projects with guidance and support from mentors affiliated with African and European institutions.

Keywords: health research systems,sub saharan africa,poverty related pediatric infectious diseases,fellow training programs,south to south collaboration,early career fellows,mid career fellows
The evolution and function of fish TRIM E3 ubiquitin ligases (FishTRIM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499228.75
EU funding (EUR): 1499228.75
Participants: 1
Project status: SIGNED

FishTRIM aims to study the evolution and function of the TRIM family of E3 ubiquitin ligases in fish. This family has undergone several clade-specific expansions across the fish phylogeny, with single-copy mammalian TRIMs frequently present in large numbers in fish genomes. TRIM E3 ligases and their direct interactions with viral proteins are key in host-pathogen relationships, and several fish TRIMs have been associated to antiviral responses. Additionally, positive selection has been observed in fish TRIM protein domains involved in protein-protein interactions and pathogen recognition. This suggests that this family of fish E3 ubiquitin ligases may act as an immune mechanism against specific viral pathogens, and therefore the repeated independent expansions of the TRIM repertoire in fish could be the result of an arms race between fish and viruses. To address these questions, FishTRIM will focus on understanding the function of this family in fish, and their potential co-evolutionary interactions with viruses. Recent advances in the fields of functional genetics and genomics, such as single-cell technologies and genome editing, allow us to interrogate gene function at unprecedented scale and resolution. Nonetheless, a phylogenomic approach will be fundamental to determine potential functional overlap across independent expansions, and selection patterns in the context of TRIM protein domains will contribute to illuminate the function of the expanded TRIM repertoire. FishTRIM aims to deliver frontier knowledge on the biological significance of the different fish TRIM expansions, with potential to revolutionise our understanding of fish immune systems and the evolution of the ubiquitination machinery. FishTRIM will also explore the role of TRIMs in resistance to viral diseases in fish, with potential transformative outcomes leading to improved fish welfare and food security.

Keywords: trim,fish,ubiquitination,e3 ligases,host pathogen interactions,gene expansions
Enhancing Capacity-building for Leveraging Innovative Procurement Strategies in Europe (ECLIPSE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Italy,Spain,Portugal,Slovakia,France
Call: Specialist Advisory Services to build capacities on innovation procurement (HORIZON-EIE-2023-CONNECT-02, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 1264486.6
EU funding (EUR): 999843.75
Participants: 7
Project status: SIGNED

InnoInnovation Procurement (IP) is a recognised strategy for driving technological development in the public sector and spurring economic growth. It modernises public services and accelerates the market entry of innovations. However, Europe has not fully tapped into its potential due to barriers. Small innovative companies should be more interested in IPs but face challenges engaging with public procurers (PPs). This is due to a) lack of awareness about public contracts and b) distrust in the procurement process. Startups find it difficult to meet the requirements and adapt to lengthy procurement procedures, leading many to avoid them. The barriers faced by public procurers when working with startups: • Qualitative selection procedures often favour large cooperations in PP, and there is little understanding of startup accreditation mechanisms. • Evaluating startups requires precise adjustments to criteria related to technical solvency, economic performance, and autonomy. • Establishing testing environments like regulatory sandboxes and granting temporary testing licenses for startups. • Understanding acceptable payment options and liquidity needs specific to startups in procurement processes. The ECLIPSE project will design and test a new cutting-edge interaction model to connect PP and innovative suppliers with investor ecosystems. Special attention will be dedicated to the role of venture capitalists and how they can effectively contribute to the IP process and foster the market exploitation of its results. ECLIPSE will build a system of tailored advisory services and tools to bridge the gap between PPs’ needs and innovative suppliers' capabilities. These services will possess the expertise and competencies necessary to overcome barriers that impede the integration of innovation in public sector. By leveraging their specialised knowledge, the advisory services will enhance coordination among Member States and Associated Countries in procuring innovative solutions.

Keywords: private investors ecosystem,public investors,venture capital,innovation ecosystems
Diagnostic and Antibiotic Stewardship for Urinary Tract Infections Using Fit-for-Purpose Diagnostic Tools (UTI-Diag)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Sweden,Senegal,South Africa,United Kingdom,Germany,Finland,France,Cameroon
Call: Advancing point-of-care diagnostics to the market (HORIZON-JU-GH-EDCTP3-2023-02-two-stage, 2023)
Start date: 2025-03-01
End date: 2028-08-31
Duration (months): 42.0
Total project cost (EUR): 3944941.38
EU funding (EUR): 3944941.38
Participants: 11
Project status: SIGNED

Urinary Tract Infections (UTIs) and antimicrobial resistance (AMR) pose significant global health threats, characterised by high incidence and mortality. However, in Sub-Saharan Africa (SSA), there is often a lack of accessible diagnostics to guide proper treatment and therapy monitoring. Our objectives are as follows: (1) Develop and validate a two-tier diagnostic toolbox: (a) Implement a Lateral Flow Test (LFT) for detecting urinary biomarkers at primary care for triage; (b) Deploy a compact, portable Point-of-Care (POC) instrument for secondary care (hospitals, clinics), integrating pathogen detection via isothermal nucleic acid amplification and host-response biomarker quantification for evidence-based therapy and antibiotic prescription; (c) Introduce novel (self)-sampling cards for transport without the need for a cold chain; (d) Establish a digital health platform for clinical decision support. (2) Evaluate the toolbox's field deployability, acceptance, usability, and integration into clinical practice. (3) Maximise the adoption, implementation, and accessibility of the proposed diagnostic toolbox. (4) Prepare for post-project regulatory approval and market launch. (5) Enhance capacity building and surveillance structures through local manufacturing transfer and improvement of the supply chain and logistics. We will recruit diverse patient groups, including under-represented segments of society, from various African settings to ensure the broad applicability, sustainability, and customisability of our solutions. This project is expected to have a significant impact, improving the quality of UTI/AMR diagnostics, reducing unnecessary antibiotic use, preventing resistance, strengthening health systems and their response to epidemics, and increasing accessibility and quality of diagnostics through interdisciplinary and robust industrial collaboration.

Keywords: urinary tract infections,antimicrobial resistance,lateral flow tests,point of care diagnostics,self sampling,clinical studies
COMPACT REPRESENTATION OF MULTI-MODAL TRANSITION FROM HIGH-FIDELITY DATASETS OF UNSTEADY FLOWS (COMPOSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 2
Project status: SIGNED

Laminar-to-turbulent transition, which critically affects efficiency-focused applications such as wind turbine blades and aircraft wings, remains poorly understood. These flows involve complex turbulent interactions (high turbulence levels, unsteady wakes, separated shear layers), which standard modeling techniques struggle to accurately capture. This project addresses these challenges by leveraging high-fidelity experiments and numerical simulations to study transition flow physics. While these techniques offer unparalleled detail, the resulting large datasets are difficult to interpret and integrate due to the diverse flow conditions and geometries involved. As a result, the datasets are not immediately usable for developing low-order models and flow control strategies. The project's goal is to create a compact representation of the complex transition scenario using a data-driven and theoretical framework. This methodology will reveal the driving effects behind the amplification of unstable coherent flow structures during transition. It will integrate three high-fidelity heterogeneous experimental and numerical datasets of turbomachinery flows at engine-relevant conditions. The COMPOSE project leverages these datasets to provide insights applicable across various fields where transition impacts performance. The outcomes will not only deepen our understanding of laminar-to-turbulent transition but also enable the development of accurate reduced-order models. These models will be essential for creating flow control strategies to reduce the adverse effects of transition in aerodynamic components, such as turbomachinery blading, wind turbine blades, and aircraft wings. The project's impact could lead to significant efficiency improvements in these components, with broad implications for the aerospace and energy sectors.

Keywords: laminar to turbulent transition,turbulence,data driven decomposition,linear stability theory,turbomachinery,large heterogeneous dataset,high fidelity experiments,direct numerical simulation
Brain fluids - Transport and clearance (aCleanBrain)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Norway
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 2493750.0
EU funding (EUR): 2493750.0
Participants: 1
Project status: SIGNED

Scientific breakthroughs in neuroscience explain the need for sleep and the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases in terms of fluid dynamics: the waste created during the day is cleared away as we sleep or it accumulates. However, a decade of research after the original theory was posed has revealed that the underlying physical mechanisms are still not understood and that the advanced mathematical tools are needed. In this project we propose a research program addressing 1) new fluid dynamics mechanisms, 2) novel numerical analysis for advanced multi-physics brain simulations, and 3) a framework for patient-specific simulations. We will exploit reduced order and machine learning methods in addition to finite element solutions. With successful delivery, the "aCleanBrain" will establish the main drivers of brain fluid dynamics, provide a foundation for accurate, efficient and robust algorithms for multi-physics problems and develop a software framework for advanced biomechanical brain simulations.

Keywords: multilevel,multi physics,preconditioning,glymphatic system,computational physiology,biomechanics