Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Induced fit as a generalizable strategy to accelerate biosensor kinetics for continuous monitoring applications (CIFS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 217076.16
EU funding (EUR): 217076.16
Participants: 1
Project status: SIGNED

The advent of continuous monitoring has transformed the treatment of patients with chronic diseases such as diabetes, offering real-time information on their blood sugar levels. Nevertheless, the advancement of continuous monitoring biosensors (CMB) for additional biomarkers beyond glucose is impeded by the slow dissociation kinetics of numerous recognition elements utilised in CMB, resulting in time lags and erroneous determination of concentrations. This proposal aims to address this universal problem in continuous monitoring by shifting the focus to the kinetic programming of biosensors. In particular, my goal is to develop a novel and universal sensing architecture that will enhance the performance of CMB by accelerating the binding and unbinding events between a bioreceptor and its analyte. To this end, I will leverage my foundational work on nature-inspired regulatory strategies to implement the induced fit (IF) strategy in CMB. This innovative approach has the potential to markedly enhance the performance of CMB for a diverse array of sensing applications, facilitating more precise and rapid monitoring of biomarkers in a multitude of clinical settings. This fellowship built on my background in fundamental chemistry, leveraging my experiences in exploring new concepts for biosensing using DNA-based models and combining that with the recognized expertise in synthetic biology, protein engineering, and biosensors of Prof. Maarten Merkx at Eindhoven University of Technology (TU/e, Netherlands). In addition to the research component, this fellowship will provide me with transferable skills that are essential for a successful academic career, including proposal writing, student supervision, leadership, and event organization. The research opportunities and professional development offered by this fellowship would be invaluable in helping me establish myself as an independent and successful principal investigator.

Keywords: antibody based sensors,continuous monitoring,induced fit,kinetic programming,lucos
Tuning the electronic structure of two-dimensional semiconductor junctions (2D-InTune)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Canada
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

Lateral junctions between two-dimensional (2D) semiconductors are conceptually the smallest possible electronic devices. This project investigates the basic physics of these systems as the type of band alignment, the band bending and depletion region, which are decisive parameters for any application. Semiconductor junctions composed of 2D transition metal dichalcogenides (TMDs) will be prepared on hexagonal boron nitride (hBN) or graphene (Gr) on Ir(111). The use of the single-crystalline metal substrate allows the application of surface science methods for preparation and characterization, while the ultrathin buffer layer leaves the intrinsic properties of TMDs undisturbed. Intercalation of guest atoms between the buffer layer and Ir will be used as an elegant and non-invasive method for doping the TMDs. This will also tune intrinsic band bending at the 1D-interface of the TMD junctions, which is yet to be explored for various 2D systems. To separate the effect of inhomogeneous doping and inhomogeneous structure, two types of lateral TMD junctions will be prepared: Homojunctions will be achieved by doping only one part of the TMD island by extending it over the interface of intercalated patches in hBN. Heterojunctions will be composed of two different TMD materials grown on homogeneous vdW substrate, either fully intercalated or pristine. Samples will be prepared by combining two TMDs (ReS2 and WS2) and two dopants (n and p). Scanning tunneling spectroscopy (STS) and Kelvin probe force microscopy (KPFM) will be used for the characterization of the 1D-interfaces and the reconstruction of the band diagrams. Dielectric screening induced by the substrate will be analyzed by comparing values of the band gaps and shifts of critical energy points between different systems. This will deepen the understanding of the origin of band bending in 2D systems. Inelastic electron tunneling spectroscopy (IETS) will be used as a potentially new technique for detecting excitons.

Keywords: scanning tunneling microscopy spectroscopy,kelvin probe force microscopy,inelastic electron tunneling spectroscopy,intercalation,epitaxial growth,ultra high vacuum,band bending,1d interfaces
Metal nanoapertures by nanoimprint to enhance single molecule fluorescence detection (PrintNano4Fluo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

After two decades of parallel developments in single molecule fluorescence techniques and nanophotonics, these two fields remain largely disconnected today. The aim of the PrintNano4Fluo project is to bridge this gap and bring nanophotonics tools to the end users single molecule microscopists. Our objective is to develop a new cost-effective and scalable nanofabrication approach of nanophotonic devices to enhance single molecule fluorescence detection. The PrintNano4Fluo solution offers a unique set of advantages: it is low-cost, fast, scalable and safe while still providing a high optical performance of the final. Bringing nanophotonics tools to the end users single molecule microscopists is a major element of novelty to break into the physical limits set by diffraction where no other alternative exists today.
Inverse Design of Optoelectronic Phosphosulfides (IDOL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2028-08-31
Duration (months): 68.0
Total project cost (EUR): 2263750.0
EU funding (EUR): 2263750.0
Participants: 1
Project status: SIGNED

Progress in sustainable energy technology relies on the discovery of new earth-abundant materials with unprecedented ability to conduct ions, catalyze reactions, transport photogenerated carriers, etc. The main scientific question is how to find the materials with exactly the desired functionality from the huge pool of all possible materials (more than 10^12). In IDOL, we will attempt to answer the long-standing question of inverse materials design. Our targeted functionality is high optoelectronic quality (i.e., long photocarrier lifetimes, high mobilities, and high absorption coefficient) in an earth-abundant semiconductor with band gap above 1.5 eV. This will be a breakthrough in three areas key to a sustainable energy future: multijunction photovoltaics, light-emitting diodes, and solar fuels. The IDOL approach is a combination of experimental and computational research, focusing on the most device-relevant material form: thin films. Initially, we will restrict our search to the intriguing and still highly underexplored family of phosphosulfides (PSs). Later, we will extend our insights to other chemistries. From my preliminary investigation, many PSs should exhibit high mobilities and appropriate band gaps. We will break the inverse design problem into logically connected steps: from application-specific figures of merit, going back to defect properties, generic optoelectronic properties, structure, growth conditions, and composition. We will exploit a unique combinatorial deposition system to grow candidate materials and characterize them using high throughput facilities at our host. For properties not experimentally accessible, we will employ first-principles calculations. This hybrid dataset will be analyzed step-by-step by human intelligence and machine learning to formulate design criteria and generate new materials with the desired properties. The discovered PS with the highest figures of merit will be incorporated into an actual photovoltaic device.

Keywords: optoelectronics,photovoltaics,phosphides,sulfides,high throughput experiments
New era in dark matter phenomenology, the dawn of the nuclear clocks (DM-Dawn)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Israel,Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2271204.0
EU funding (EUR): 2271204.0
Participants: 4
Project status: SIGNED

What is the nature of dark matter (DM)? This central question in physics could be soon addressed thanks to the unprecedented sensitivity of nuclear clocks. These Th-229-base clocks are set to overcome the inherent limitations of atomic and molecular clocks, which are less sensitive to the nuclear parameters, which dominate almost all motivated models of ultralight DM (ULDM) . Laser excitation of Th-229 has just reached 1:10^11 sensitivity. Given that a precision of 1:10^8 suffices to probe DM-models with world record reach (even before nuclear clocks are actually constructed), it implies that the era of nuclear clock supremacy has begun! We propose three thrusts that harness this revolutionary advancement to search for ULDM. The first is driven by our joint theory-experiment demonstration that the line shape analysis of the Th-229 isomeric state excitation may potentially lead to 1:10^21 effective sensitivity to ULDM, due to the direct-enhanced dependence on the strong interaction parameters. The second is theoretical and experimental exploration of the enhancement factor of O(10^5), that is currently uncertain, and cannot be robustly established. The third focus on studying the formal implications of the era of nuclear-clock supremacy. We provide projection for the reach of nuclear clocks for axion and scalar ULDM. We also demonstrate that a nuclear clock can be used as a QCDometer sensing spatially-dependent couplings, due to artificial source, or from super-Planckian-based physics via couplings to moduli-remnants. We further introduce a new class of non-axion ULDM models, that address the strong CP problem, where the Cabibbo–Kobayashi–Maskawa elements vary in time, in addition to the nuclear parameters. It could be tested, thus, at accelerators as well as clocks, which leads to a novel synergy between different frontiers of physics. The proposal transforms future technologies into a concrete search for DM and beyond, ushering us into the era of nuclear clocks.

Keywords: nuclear clock,ultralight dm
Ageing in the Carceral Environment: The Existential Dimensions (CAGED)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Belgium,Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-09-30
Duration (months): 66.0
Total project cost (EUR): 1475000.0
EU funding (EUR): 1475000.0
Participants: 2
Project status: SIGNED

The worldwide increase in the number of individuals that are ageing behind bars sparks heightened concerns about the extent to which carceral environments can foster the foundational conditions for ageing individuals to lead meaningful lives. However, the underdevelopment of research on carceral ageing is one of the most significant contemporary challenges in the social scientific study of criminal behaviour and society’s response to it. Scholarship is particularly lagging behind in Europe. The CAGED project addresses this critical need by understanding how existential psychosocial changes induced by human ageing intersect with effects of incarceration. It is designed to bridge two distinct academic realms: gerontology, which encompasses the multidisciplinary study of ageing, and penology, which is the study of punishment and incarceration. The project will push disciplinary boundaries, both methodologically and theoretically, by applying an interactive mixed-methods and interdisciplinary approach that is guided by three objectives: First, it will delve into the existential dimensions woven into the narratives of incarcerated ageing individuals, by employing multi and novel interviewing methods. Secondly, the project will develop a novel instrument for measuring existential meaning among diverse regimes and groups of ageing individuals. The measurement will encompass all carceral environments in Belgium. Renowned for its diverse approaches to the integration and segregation of older individuals in carceral settings, it makes an excellent case study with broad relevance across European jurisdictions. The measuring study will also extend to an age-segregated facility for older adults in Germany, unique in Europe. In bringing these insights together, the project will finally culminate in a ground-breaking interdisciplinary theoretical framework. In its pursuit, CAGED will propel the field of carceral ageing studies forward and launch a new field of geronto-penology.

Keywords: ageing,incarceration,existential dimensions,meaning,mixed methods,interdisciplinary
Demonstration of a CNS data service provision (CNS DSP) (CNS DSP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: France,Ireland,Italy,Poland,Switzerland
Call: Fast Track Innovation and Uptake Virtualisation and Cybersecure Data-Sharing (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 4098832.5
EU funding (EUR): 2845214.46
Participants: 9
Project status: SIGNED

CNS DSP (Data Service Provider) refers to the development of digital platforms and services leveraging state-of-the-art technologies to enable future data-sharing service delivery models. It aims at sharing CNS data between ANSP and providing to other stakeholders (Civil & Military Airspace Users, Industry, Airport Authorities, Regulators & ATM Organizations, Aircraft Manufacturers). The project aims at implementing a demonstrator based on several ANSPs data and for the usage of third parties application/service developers (supporting ADSP concept). The CNS Data Service Provision project (hereinafter referred as “CNS DSP”) aims to support the transition to the new service delivery model for ATM data through the development of a new SESAR solution, the “Shared CNS Data Services Platform”. This solution will deliver the CNS Data Services required by ATC & Airspace users, in full consistency with the ADSP concept. It will also offer a bunch of added value services for various Aviation and UTM stakeholders, enabling the valorisation of ANSPs CNS data for the entire Aviation community.

Keywords: cns,data service,virtualization,api,ansp,cross border atm,flexibility,adaptability,infrastructure,downstream applications,
DOING THE IMPOSSIBLE - adaptive behaviour in migratory birds to overcome physiological and environmental constraints (MigPerform)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499921.0
EU funding (EUR): 1499921.0
Participants: 1
Project status: SIGNED

Advances in tracking technology during the last decade have shown that migratory birds have the capacity to fly longer and faster than we previously thought was possible. Yet, we do not know how birds perform these seemingly impossible travels as it previously only was possible to record spatiotemporal patterns. The overall aim of this project is to reveal constraints and the behavioural and physiological adaptations that has evolved to overcome them, thus making the extreme performances of migratory birds possible. This goal will be met by using novel tracking devices, multisensor data loggers, that in addition to spatiotemporal patterns also record behaviour, including flight altitudes, temperature and detailed timing of flights and stopovers during the entire migration cycle. The few multisensor tracking studies carried out to date have provided hints of stunning new insights, and seriously challenged previously assumed limits on peak flight altitudes, in-flight changes of altitudes, and duration of individual flights. In particular, I have together with colleagues discovered a totally unexpected altitudinal behaviour: some bird species change their flight altitude between night and day, and fly at extremely high altitudes during the day (up to 6000-8000 m). But what makes a migratory bird fly as high as Mount Everest, even when there are no mountains to cross? By launching an extensive multisensor data logging programme, combined with wind tunnel experiments and field studies, the proposed project will change our understanding of the possibilities and limitations of bird migration. This will be done by disentangling the causes and consequences of bird’s altitudinal behaviour, the flexibility, timing and duration of migratory flights (if birds only use diurnal or nocturnal flights, if they prolong flights to last both day and night or even fly nonstop between wintering and breeding grounds), and the costs and consequences of these seemingly extreme behaviours.

Keywords: migration ecology,migratory performance,ornithology
Next Generation Computer Assisted Reasoning (NextReason)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Sweden,Czechia
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2499057.0
EU funding (EUR): 2499057.0
Participants: 3
Project status: SIGNED

Galileo said that mathematics is the language of science. It is used to solve arbitrary abstract problems, underpinning hard sciences, technology and engineering. Automation of complex mathematical reasoning, discovery and large-scale formal proofs is today one of the greatest challenges in the fields of Automated Reasoning (AR) and Artificial Intelligence (AI). Compared to human experts, today’s main automated reasoning and theorem proving paradigms are severely one-sided: they largely lack the capability to combine learning, reasoning and conjecturing in complex feedback loops. There is solid evidence that such combinations are the key to building the next generation of advanced reasoning systems for mathematics, computer-assisted proof and formal verification. The NextReason project will create one of the world’s strongest teams working on such combinations. We will jointly develop (i) logic-aware learning architectures and neuro-symbolic methods for a range of automated and interactive theorem proving paradigms, (ii) novel AI approaches for learning-guided automated decomposition of hard reasoning problems, (iii) methods for automated formalization of human-written mathematics by combining learning-based translation methods with semantic methods such as type-checking and theorem proving, (iv) neuro-symbolic methods for synthesis of interesting mathematical objects, conjectures and explanations, and (v) autonomous systems and positive feedback loops interleaving learning, theory exploration and efficiently guided proof search to attack hard and open problems. The expected overall outcome is a new generation of strong architectures for reasoning and theorem proving, and their transformative effect on large-scale computer-assisted proof, mathematics and formal verification.

Keywords: automated reasoning,automated theorem proving,interactive theorem proving,formal proof,automating mathematics,formalized mathematics,ai and theorem proving
Supporting Local Economic Development with Business Transaction Data (SUPPED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Austria,Hungary
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 2
Project status: CLOSED

This project aims to develop tools and solutions that turn value-added tax (VAT) records into an information system that can support evidence-based policy making and the development of regions, industries and firms in general.

Keywords: business transaction networks,networks,value added tax,geography,agglomeration