Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
APC/C substrates: how are they disengaged from their non-degraded binding partners? (UbiBranch)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

The anaphase promoting complex/ cyclosome (APC/C) is an E3 ubiquitin ligase that controls the cell division cycle by targeting main cell cycle regulators for proteasomal degradation, thereby ensuring error-free cell division and safeguarding genome stability. Its foremost activity is during cell division, or mitosis, when two sets of sister chromatids are equally divided over two newly formed daughter cells. Intriguingly, APC/C substrates that are degraded at the metaphase-to-anaphase transition have binding partners, which are not degraded. It remains a mystery how the APC/C controls degradation of the substrates and leaves the binding partners undisturbed. My objective is to clarify the molecular mechanism of substrate-binding partner disengagement, and determine the impact of disengagement on substrate degradation, to ensure controlled sister chromatid separation and genome integrity. First, I propose to identify the precise timing of disengagement during the process of ubiquitination, at the molecular level: this will give fundamental insight into disengagement control (Objective 1). Next, I will study ubiquitination at the proteomics level, by unraveling how Lysine-choice, and ubiquitin chain topology affect disengagement (Objective 2). Finally, I will combine conventional molecular biology methods with advanced microscopy techniques to investigate the importance of controlled substrate-binding partner disengagement for substrate degradation and genome stability (Objective 3). I will employ a multi-disciplinary approach, combining molecular biology, proteomics, and in vivo cell biology approaches to resolve this fundamental biological question. The identified mechanism may provide insights into ternary complex formation of the APC/C and its substrates, which will enable translation to develop targeted-protein-degradation drugs.

Keywords: ubiquitination,cell cycle,cyclin b1,securin,geminin,protein degradation,ubiquitin proteasome system,cell biology,fluorescence imaging,mass spectrometry
Activation of mitochondria during embryogenesis (MitoZebra)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

Mitochondria are well known as the powerhouse of cells and play a vital role in embryo development regulating energy homeostasis. Mitochondrial function has been studied for decades, although several aspects of mitochondrial metabolism during development still remain unclear. Which mechanisms are responsible for the continuous increase in respiratory chain activity during embryogenesis? How does translational activity in the early embryo contribute to this process, and how is the translational activity in mitochondria coordinated with the translational activity in the cytoplasm? In my project, I will investigate mechanisms that underlie the increase in mitochondrial energy production during embryogenesis. Using zebrafish embryos as a model system for vertebrate development, I propose to measure mitochondrial translational activity with de novo translation assays and assess its contribution to the assembly of new respiratory chain complexes. Also, I will explore the largely enigmatic mechanism of the co-regulation of cytoplasmic and mitochondrial translation. My research will provide novel insights into the universal yet poorly understood mechanisms that activate mitochondrial function after fertilization. Since in the early embryo nucleus is transcriptionally inactive, my work has the potential to discover novel, transcription-independent feedback-mechanisms that balance mitochondrial and cytoplasmic translations.

Keywords: zebrafis,embryogenesis,mitochondria,cytoplasmic and mitochondrial translation,respiratory chain
Transport derived Ultrafines and the Brain Effects (TUBE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Finland,Sweden,China,Finland,Hungary,Finland,Czechia,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,Chile
Call: InCo flagship on reduction of transport impact on air quality (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-05-01
End date: 2023-10-31
Duration (months): 54.0
Total project cost (EUR): 5989370.0
EU funding (EUR): 5049876.0
Participants: 17
Project status: SIGNED

The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.

Keywords: brain health,nanoparticles,traffic,alzheimer s disease,genotoxicity,inflammation,inhalation toxicology,in vitro,in vivo,neurotoxicity
REAL CONSUMER ENGAGEMENT THROUGH A NEW USER-CENTRIC ECOSYSTEM DEVELOPMENT FOR END-USERS’ASSETS IN A MULTI-MARKET SCENARIO (REDREAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Italy,Spain,Italy,Croatia,Greece,Belgium,France,France,United Kingdom
Call: Consumer engagement and demand response (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 7204530.0
EU funding (EUR): 5992597.5
Participants: 18
Project status: SIGNED

Within the Energy Union framework, the European Union (EU) is aiming at transforming the energy systems towards a sustainable, low-carbon and climate-friendly economy, putting consumers at its centre. Buildings play a key role in this transition as, on one hand they are responsible for approximately 40% of energy consumption and 36% of CO2 emissions in the EU and, on the other hand, the potential engagement of consumers through the demand-response mechanisms. To enable this transformation, distribution grids will face news paradigms in the ways they operate relying more on flexibility smart grids with capacity to safely host more renewable energy sources (RES) and integrate new loads, such as power to heat/cold, power to gas/liquid and new technologies, as well as electric vehicles (EVs) while advancing in security of supply and affordability. Therefore, this global picture will demand the generation of a new concept of connected ecosystem between energy system players and consumers. Under this scenario, the project consortium accepted this challenge and offers to develop the “REDREAM Project”, which not only will enable the effective participation of the consumers/prosumers in the energy market, but also will drive a profound change turning traditional company’s value chain into value generation chain, based on a revolutionary Service Dominant Logic paradigm. The main objective of the REDREAM project is to effectively move the consumer (as a residential, industrial and tertiary consumer) participation to the centre of the energy market through an open and co-creative ecosystem where all stakeholders will actively interact. This ambitious challenge will require the collection of demand response tools and services (energy and non-energy) capable of enabling the capacity for the consumers of participating in the energy market through an improvement of predictability of consumption patterns and consumer behaviour.

Keywords: prosumer,consumer engagement,demand response,open co creation,energy services,non energy services,renewable energy resources,flexibility,energy efficiency,digital twin,energy social network
Chromatin and Metabolism Chromatin-metabolism interactions as targets for healthy living (ChroMe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Germany,Germany,Spain,Spain,Sweden,Switzerland,France,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 3825128.16
EU funding (EUR): 3825128.16
Participants: 15
Project status: CLOSED

Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chromatin are poorly understood, and drug targets are only starting to be identified. Pioneering experiments by ChroMe labs now reveal how sugars, exercise, the gut microbiome and novel drugs regulate chromatin. These novel links promise to substantially improve our understanding and treatment of metabolic disorders. National governments and the EU invest major resources to address the burden of the “metabolic syndrome”. However, there is an urgent need for expert human capital able to dissect metabolic diseases, exploit new targets and establish innovative therapies. No local nor international program currently provides adequate training at this emerging interface of chromatin and metabolism. ChroMe establishes a timely and intersectorial ETN that exploits Europe’s strengths in epigenetics, physiology and medicine to translate our molecular knowledge of chromatin–metabolism interactions into therapies. Our ESRs receive advanced training in emerging technologies, bioinformatic and translational approaches, and all engage in collaborative PhD projects co-supervised by academia and industry. ChroMe’s extensive transferable skills, dissemination and public engagement program equips our ESRs with the experience and personal network needed for a career in metabolic health. By systematically involving the non-academic sector at every level in our research, training and management, ChroMe will craft future European leaders with the necessary knowledge and skills to fight the metabolic syndrome pandemic.

Keywords: chromatin,gene expression,gene regulation,bioinformatics
EFFICIENT INDUSTRIAL GENERATION OF HIGH-PURITY O2 IN IONIC MEMBRANE MODULES (GO2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objective of GO2 project will be focused on the development and further commercialization of an innovative system able to produce high purity oxygen (>>99.5%) at high temperature (1000ºC) by means of advanced membrane modules (high temperature ion conducting ceramic membranes). KERIONICS products are able to supply oxygen with a cost reduction between 20-80% regarding the current technologies for industrial applications that requires oxygen or enriched air and to capture CO2 using the most efficient technology. GO2 project will have a major impact on European industry because the use of oxygen or enriched air improves the plant efficiency and GO2 technology can reduce CO2 emissions by means of the reduction in fuel consumption using technically efficient CO2 separation. Energy-intensive industry processes based on combustion and oxidation at high temperature can achieve an impressive 24-month payback using this technology.

Keywords: business plan,oxygen supply,energy efficiency,advanced ceramic membrane,nanomaterials,co2 reduction
ADVANCED MATERIALS AND PROCESSING IN ORGANIC ELECTRONICS (MADRAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,France,France,France,France,Czechia,Netherlands,Denmark
Call: Materials, manufacturing processes and devices for organic and large area electronics (IA) (H2020-NMBP-TR-IND-2019, 2019)
Start date: 2020-04-01
End date: 2023-06-30
Duration (months): 39.0
Total project cost (EUR): 5013919.11
EU funding (EUR): 4225657.88
Participants: 14
Project status: SIGNED

MADRAS project aims to demonstrate a materials-driven improvement of OLAE devices, establishing a high speed manufacturing methodology in a scalable competitive process which is In Mold Hybrid Printed Electronics (IMHyPE). Four high performance materials to be developed in MADRAS tackle high cost, instability and short lifetime of OLAE devices under operational conditions through the development of robust alternatives and innovative approaches. Such materials are a conductive and transparent substrate, a semiconducting transparent ink based on organic components, a transparent conductive silver nanowire-based ink and a semiconductor ink based on metal oxide nanoparticles. MADRAS project also addresses the need for innovative and industrial manufacturing processes for the development of robust series of flexible plastronic products. Building on an already established technology as plastic injection, will facilitate a faster uptaking. The advantages of IMHyPE are numerous and include: light weighting, space-saving, robustness, accelerated time-to-market, and high throughput capabilities. It will demonstrate processability, stability, operational lifetime and seamless integration of new products as well as of new technology into traditional goods. Therefore, MADRAS proposes two products for persons’ authentication market and smart manufacturing that will show a step forward towards digitisation and Internet of Things for its contribution to the sustainable deployment of smart products for consumer use. Ethical issues for these matters are properly addressed. Such products belong to the global emerging trend of structural electronics with very large addressable markets as Automotive sector, healthcare and many others. The workplan sets and consolidates the value chain through the participation of six SMEs, four RTOs, one large company and one standardisation association completing MADRAS consortium assuring high impact boosting activities.

Keywords: printed electronics,in mold,photosensor,printed antenna,autonomous devices,smart tag,conductive inks,silver nanowires,pedot,tungsten oxide,nanocellulose,spray coating,screen printing
Prototype for an Ultra Large Structure Assembly Robot (PULSAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Switzerland,Belgium,France,France
Call: SRC – Space robotics technologies (H2020-SPACE-2018, 2018)
Start date: 2019-02-01
End date: 2021-03-31
Duration (months): 26.0
Total project cost (EUR): 3999233.0
EU funding (EUR): 3999021.25
Participants: 8
Project status: CLOSED

Autonomous assembly of large structures in space is a key challenge to implement future missions that will necessitate structures too large to be self-deployed as a single piece. The James Webb Space Telescope has reached this limit and the next generation telescope expected by astronomers, like the High Definition Space Telescope, will therefore require new assembly technologies, in particular autonomous robots. The need for large structures in space goes beyond telescopes and concerns also solar arrays for power plant, light sails to reach outermost regions of the solar system or heat shields to land on Mars. PULSAR objective is to develop and demonstrate key technologies for in-space assembly of the primary mirror of a 12m diameter telescope. Previously developed building blocks, c.f. first call of the SRC Space Robotics Technology, will be integrated and enhanced for this specific mission, but also to serve future multi-mission applications. The project focuses on the assembly of a mirror but the developed technology will be applicable to other large structures. Indeed, assembling a mirror requires far more rigor and accuracy than other identified structures. PULSAR is organized in three demonstration tracks to address major challenges of in-space autonomous assembly of telescope: dPAMT, demonstrator of Precise Assembly of Mirror Tiles; dLSAFFE, demonstrator of Large Structure Assembly in Free Floating Environment; dISAS, demonstrator of In-Space Assembly in Simulation. Although three demonstrators will be developed, the underlying technology will rely on common building blocks whose use and improvement will benefit from the expertise of the PULSAR partners. Building blocks upgrades will then be supplied to their respective maintainers to pursue the standardization of modular and reusable components for space and non-space robotics. PULSAR is responsible of OG5/SIROM, and will contribute to the development of ESROCOS, ERGO, INFUSE and I3DS.

Keywords: robotic arm,extended mobility,software simulation,underwater demonstrator,path planing,visual localisation and modeling,optimized aocs,segmented mirror,on orbit assembly of large structures
Targeting ubiquitin processing in cancer and fibrosis: novel probes for the Ubiquitin Carboxy-Terminal Hydrolases (TargetDUBs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-08-14
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Modification of proteins with ubiquitin (Ub), itself a small protein, is a fundamental mechanism involved in regulation of almost all cellular functions. There are hundreds of enzymes involved in the addition or removal of Ub, and this system has emerged as an important drug target in many diseases. Ubiquitin Carboxy-Terminal Hydrolase L1 (UCHL1) is a member of the UCH family of deubiquitinases (DUBs), and is the most abundant protein in the brain. UCHL1 dysregulation has been shown to be associated with neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, various types of cancers (colorectal, breast, prostate, ovarian, and lung cancers), and liver fibrosis. However, its actual functions, endogenous substrates, and how its activity is regulated in vivo, both in pathological and healthy tissues, remain poorly understood. To overcome these limitations and to realize the unmet therapeutic opportunities, I will develop and synthesize activity-based probes to selectively target UCHL1, and will apply them to the identification and quantification of UCH enzymes in several cancer cells using activity-based protein profiling. This will provide a unique tool to explore a wide range of DUBs and UCH biology in cells, as well as a starting point to develop selective inhibitors and potential therapeutics. Simultaneously, I will develop and synthesize irreversible PROTACs to selectively degrade UCHL1 and will apply them to quantitatively assess their effect on UCH enzymes in several in vitro cancer and fibrosis models using proteome-wide proteomics experiments. PROTACs are two-headed molecules capable to direct E3 ubiquitin ligase activity towards the target protein, driving its degradation by proteasome. I anticipate that novel PROTACs based on inhibitors that target UCHL1 would provide a unique tool to degrade UCHL1 and prevent deubiquitination, assisting discovery of novel UCHL1 substrates and providing a new paradigm for targeting UCHL1 in disease.

Keywords: activity based probes,protacs,in vitro and cell based assays