Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microbial Remediation of Agricultural Land (MICROREAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Türkiye
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

NGB has developed and brought to TRL6 its MICROREAL microbial formulation soil conditioner. It degrades persistent pesticide residues, restores soil biota diversity, increases the availability of essential nutrients, stimulates the natural defences of plants against pathogens, and reverses the damage done to land by decades of intensive agriculture and horticulture. MICROREAL is targeted at the intensive glasshouse horticulture industry and is for growers wishing to cut pesticide and fertiliser inputs, cut operation costs, and shift rapidly to a sustainable, integrated and more profitable horticulture. We have carried out limited trials in commercial glasshouses used to produce high value salad vegetables at several farms in Turkey, with the following results: - eliminates organochlorine residues to below detectable levels within 48h - triggers induced systemic resistance in plants against pathogens - sequesters iron ions and inhibits the proliferation of pathogenic soil fungi - lowers the total amount of pesticides applied to glasshouse crops - increases the availability of N, P and K in soils. Growers can cut artificial fertiliser applications by up to 50% - Yield increases of 30-50% NGB seek Phase I funding for a feasibility study that will examine the market and commercial viability of MICROREAL, prior to maturation in a future Phase II. The feasibility study will produce: - A market study on the European glasshouse horticulture industry, its geographic centres, main products, costs and pesticide use - An analysis of competitor microbial products for soil remediation and fertility restoration - A quantification of the economic benefit of MICROREAL to end users - The scale-up needed at NGB and the geographic expansion needed of our value chain to cover European and Asian markets - A work plan and budget for a MICROREAL Phase II

Keywords: pesticide residues,soil bioremediation,glasshouse horticulture,soil fertility,nutrient availability,induced systemic resistance,integrated pest management,organic horticulture
Infection of the human intestine by enteroviruses: A CRISPR-based screening approach (EvISC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Enterovirus infections are of public health concern as globally millions of people become infected each year. Enteroviruses (HEV) are an assemblage of highly diverse positive-stranded RNA viruses that belong to the Picornaviridae family. Four out of the 13 known enterovirus species are human pathogens, with poliovirus being the most prominent member. The entry point for these viruses is the gastrointestinal or the respiratory tract from where they can spread to other organs and cause severe pathologies. Vaccines exist only against polio and no therapies are currently available against any HEV. Thus, there is a great need for new antivirals. I aim to identify host factors crucial for the HEV life cycle by performing a whole genome CRISPR loss-of-function screen in primary cultures of human intestinal epithelial cells. Importantly, the lytic nature of HEVs will allow a straightforward selection of cells that survive virus infection upon small guide RNA-mediated deletion of host genes that support HEV infection. This interdisciplinary project demands expertise both in stem cell, enterovirus biology and host-pathogen interaction, which is provided by the Jensen lab (host), the Tapparel lab (partner) and myself, respectively. Through access to intestinal stem cells and organoids from various donors and multiple HEVs I have the unique possibility to dissect host-enterovirus interactions by taking host and virus variations into account. By integrating this data, I will be able to dissect tropism both from a host and a pathogen perspective, and identify host factors that are necessary for HEV infection. This knowledge will contribute to the discovery of novel drug targets for broad-spectrum therapies against HEV infections and moreover provide me with the unique opportunity to move forward in academia and establish my own research group.

Keywords: human intestinal organoids,human intestinal stem cells,crispr,cas9,host pathogen interactions,enterovirus
A EUROPEAN COMPETENCE FRAMEWORK FOR A LOW CARBON ECONOMY AND SUSTAINABILITY THROUGH EDUCATION (ECF4CLIM)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Finland,Greece,Hungary,Romania,Portugal,Portugal
Call: Enabling citizens to act on climate change, for sustainable development and environmental protection through education, citizen science, observation initiatives, and civic engagement (H2020-LC-GD-2020-3, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 5383047.5
EU funding (EUR): 4896710.0
Participants: 10
Project status: SIGNED

Through a multidisciplinary, transdisciplinary and participatory process, ECF4CLIM develops, tests and validates a European Competence Framework (ECF) for transformational change, which will empower the educational community to take action against climate change and towards sustainable development. Applying a novel hybrid participatory approach, rooted in participatory action research and citizen science, ECF4CLIM co-designs the ECF in selected schools and universities, by: 1) elaborating an initial ECF, supported by crowdsourcing of ideas and analysis of existing ECFs; 2) establishing the baseline of individual and collective competences, as well as environmental performance indicators; 3) implementing practical, replicable and context-adapted technical, behavioural, and organisational interventions that foster the acquisition of competences; 4) evaluating the ability of the interventions to strengthen sustainability competences and environmental performance; and 5) validating the ECF. The proposed ECF is unique in that it encompasses the interacting STEM-related, digital and social competences, and systematically explores individual, organisational and institutional factors that enable or constrain the desired change. The novel hybrid participatory approach provides the broad educational community with: an ECF adaptable to a range of settings; new ways of collaboration between public, private and third-sector bodies; and innovative organisational models of engagement and action for sustainability (Sustainability Competence Teams and Committees). To encourage learning-by-doing, several novel tools will be co-designed with and made available to citizens, including a digital platform for crowdsourcing, IoT solutions for real-time monitoring of selected parameters, and a digital learning space. Participation of various SMEs in the consortium maximises the broad adoption and applicability of the ECF for the required transformational change towards sustainability.

Keywords: citizen science,trandisciplinarity,learning by doing,hybrid methods
GNSS Monitoring for Critical Applications (GMCA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Innovation actions
Countries involved: Italy,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Small and Medium Enterprise (SME) based EGNSS applications (H2020-Galileo-2014-1, 2014)
Start date: 2015-02-01
End date: 2016-09-30
Duration (months): 20.0
Total project cost (EUR): 732737.5
EU funding (EUR): 512916.25
Participants: 5
Project status: CLOSED

The objective of this project is to provide a basis upon which Galileo can be relied upon to the same extent that GPS is currently, especially by the Aviation user community and then beyond. It is proposed that DWI’s existing GNSS Performance Monitoring System (GPMS) is enhanced to include EGNSS and this platform can latterly include other constellations and augmentations for use beyond Europe. The project shall gather EGNSS signal data for analysis and comparison thereby providing the aviation community the confidence they need for including EGNSS within their planning for navigation. It will monitor new signals alongside the GPS signals and provide operationally relevant information to existing and new users of the GPMS. In addition, the system will be updated to include the capability for the monitoring of interference and spoofing.

Keywords: gmca,downstream services,gpms,galileo
The Mitochondrial Unfolded Protein Response (UPRmt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-11-01
End date: 2024-03-31
Duration (months): 65.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Mitochondria—organelles specialized in energy harvesting through oxidative phosphorylation (Oxphos)—critically influence metabolism, health and lifespan. Evolved from endosymbiotic proteobacteria, mitochondria retained the vestige of the bacterial genome, the mitochondrial DNA, which encodes 13 subunits of the Oxphos complexes, while the remaining ~80 Oxphos components and the rest of the mitochondrial proteome are encoded on nuclear DNA, translated in the cytoplasm and imported in the mitochondria. The control of the mitochondrial proteome by two genomes exposes these organelles to proteotoxic stress in case of an imbalance between the nuclear- and mitochondrial-encoded proteins. Upon such stress, several mitochondrial protein quality control (mtPQC) pathways, including the mitochondrial unfolded protein response (UPRmt), will sense, transmit and re-establish mitochondrial proteostasis through mitonuclear regulatory circuits. Although a robust UPRmt circuit improves health and lifespan in C. elegans, much less is known about mtPQC in vertebrates. We propose here to characterize UPRmt pathways across 3 species by: (1) mapping mammalian UPRmt genes and networks in vivo after the induction of the UPRmt in a large murine genetic reference population at 3 different times throughout life with 2 different inducers; (2) integrating these UPRmt networks with a wide set of clinical, mitochondrial, and molecular phenotypes collected throughout life to establish links between UPRmt mechanisms and health- and lifespan; (3) mechanistically validating the most important UPRmt pathways, using loss-of-function studies in cells, worms and mice; and (4) clinically translating promising UPRmt hits, using genetic association studies in human cohorts. The insight gained will mechanistically define the UPRmt networks from worms to humans and will provide the next step in translating the benefits of activating the UPRmt—initially observed in invertebrates—into targeted human therapies.

Keywords: bioenergetics,mitochondria,stress response,complex trait genetics,proteostasis,uprmt,genetic reference populations
SET – The defibrillator for Chronic Pain (SET - Chronic Pain)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Germany
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-10-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SET solution for chronic pain. 100 million EU sufferers, €300 billion, Age related. Current solutions do not look at data, biomarkers, or take into consideration the individual differences between patients. With real data from large groups of patients, for the first time we can characterize the autonomic nervous system, which is depreciated in chronic pain patients, and use it to fight chronic pain. With the therapy, we attack the underlying psychological cause for the pain. The SET device allows us to do this efficiently. Using ICT data, we will be able to a real progress on this large social problem. By iterating, continuing to add data, measuring results, and adjusting approaches, we can attack chronic pain and make people pain free. SET was tested at the University of Marburg with 120 patients that included 2 sham protocols. Of the non-control participants, 100% of fibromyalgia patients became pain free for six months, and 82% at the 12-month follow-up. The data, which includes all the EKG and blood pressure data from each patient session as well as the patients' initial interview and progress data from the E-learning system, will be uploaded to a MySQL database hosted on a medical grade cloud server. Data mining and analytics software will only have read access and only anonymized access will be available, so that it will not be possible to identify any individual patient. Patent protection, a highly experienced team, a clear strongly motivated market will make the company successful. In the process many therapy based SMEs will be formed and enhanced. A real solution for a debilitating social problem which invloves ICT, big data, and job creation.

Keywords: chronic pain,ageing,thieme,fibromyalgia,big data,back pain,therapy,treatment
A Wireless, Modular, Flexible, High-Density EMG Recording System (WiHDE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-03-01
End date: 2018-08-31
Duration (months): 18.0
Total project cost (EUR): 149994.0
EU funding (EUR): 149994.0
Participants: 1
Project status: CLOSED

Altered muscle activity might be co-responsible for chronic pain. Discomfort, ache and reduced mobility are, for example, associated in low back pain patients with dysfunctional activation of the spine musculature often leading to a vicious circle of overloading and inactivity. Analysing the activities of relevant muscles in real time could provide valuable feedback for new therapies. However, deriving from muscular activities pathological behaviour requires the use of a high-density electromyographic (HD-EMG) device that precisely measures muscular activity during daily activities. A HD-EMG device that can be used in such a scenario, however, does not exist. The aim of this proof of concept is to deploy WiHDE, the first fully wearable HD-EMG device with wireless transmission and local storage capabilities, able to stream data directly towards computers or mobile devices, store it locally, or to perform on-board advanced signal processing operations in real-time while the subject can freely move around. WiHDE appears in the shape of a small, unobtrusive and discrete device, which can be placed on top or in the vicinity of an HD-EMG electrode array and allows to access the muscular activity with simplicity and precision. WiHDE is safe, energy and privacy-aware, and its modular nature favours advanced sensor fusion for unprecedented versatility of use. Within this ERC-PoC, we aim to develop such a HD-EMG device by investigating different business options and by enhancing current technology at the same time. This proposed device can be used in a clinical or similar setting, e.g., for neurophysiology-based applications such as (but not limited to) prostheses control, ergonomics, sport, rehabilitation, entertainment and, of course, basic motor control research. There is also an increasing interest in this technology from sports professional and advanced amateurs, who started realizing the importance of detailed muscular information to evaluate and improve their performance.

Keywords: wireless emg,high density,rehabilitation,sport,entertainment,ergonomics,prosthesis control,safety
The Dynamic Composition of the Protein Chaperone Network: Unraveling Human Protein Disaggregation via NMR Spectroscopy (NMR-DisAgg)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Israel
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 1499956.0
EU funding (EUR): 1499956.0
Participants: 1
Project status: SIGNED

Molecular chaperones are a diverse group of proteins critical to maintaining cellular homeostasis. Aside from protein refolding, it has recently been discovered that certain combinations of human chaperones can break apart toxic protein aggregates and even amyloids that have been linked to a host of neurodegenerative diseases. The first chaperones in this disaggregation reaction that are responsible for recognizing and performing initial remodeling of aggregates, are members of the Hsp40 (DnaJ) and small heat shock protein (sHSP) families. Very little, though, is known regarding how these chaperones perform their functions, and characterization of sHsp- and DnaJ-substrate complexes by most structural techniques has proven extremely challenging, as most chaperones are dynamic in nature and typically operate through a series of transient interactions with both their clients and other chaperones. The advanced NMR techniques used in our lab, however, are ideally suited for the study of these exact types of dynamic systems, and include recently developed experiments (CEST, CPMG) that allow us to monitor the transient and low populated protein states typical of chaperone-chaperone and chaperone-client interactions, as well as to study the structure of these potentially very large protein complexes (methyl-TROSY). By exploiting these NMR methodologies and additional, novel labeling schemes, we will characterize, for the first time, the recognition and substrate remodeling performed by the many members of the DnaJ and sHsp chaperone families on their clients. We will then take these approaches one step further and develop real time NMR experiments to observe the client remodeling performed over the course of the disaggregation reaction itself. By combining advanced NMR with biophysical and functional assays, we ultimately aim to identify the specific sets of chaperones that, with the Hsp70 system, protect our cells by dissolving disease-linked aggregates and amyloid fibers.

Keywords: protein nmr spectroscopy,molecular chaperons,protein disaggregation
LAUNCH: sustainable energy assets as tradable securities (LAUNCH)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Belgium,Finland,Netherlands,Luxembourg
Call: Mainstreaming energy efficiency finance (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-05-01
End date: 2021-10-31
Duration (months): 30.0
Total project cost (EUR): 1409070.0
EU funding (EUR): 1409070.0
Participants: 8
Project status: CLOSED

The LAUNCH project will look to overcome barriers to aggregation and market scaling, accelerating the development of the SEA as tradable securities. Today the SEA market is splintered over many project and contract types, small portfolios and many methods for assessing project risk. This smothers market growth today and will continue to do so in the future. Contracts and risk assessment protocols must become standardised, in order to encourage market growth in a manner which will lay the groundwork for and accelerate the scaling of project finance in the future. Indeed, in order for the sustainable energy market to reach its full potential, we must lay the groundwork required to accelerate the development of Sustainable Energy Assets (SEA) as tradable securities. This is the aim of the LAUNCH project. This will be done through, setting up systems to prepare SEA developers for equity investment, standardising developer-end client contracts, and creating a commonly agreed set of risk assessment protocols. The consortium has wide market reach and access to best in class materials. LAUNCH will develop these deliverables further in direct cooperation with a representative group of the European Finance Industry and a substantial pool for SEA developers and pilot them in real market conditions in cooperation with SEA developers and funds. The combination of development with key players and immediate real-life uptake, will ensure the project results are market ready and fully exploitable. The project will provide a basis for accelerated and sustainable SEA market growth and aims to create a European standard for the SEA market going forward. The main resulting benefits will be accelerated growth of the SEA industry, including substantial job growth, energy and CO2 savings and further standardisation of SEA, laying the groundwork for their acceptance as tradable securities.

Keywords: tradable securities,sustainable energy asset standardisation,energy efficiency finance,pilot