Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling the pathogenic cell-cell circuits underlying the tissue memory of non-alcoholic fatty liver disease (ForgettingNAFLD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: CLOSED

With the obesity epidemic, global prevalence of non-alcoholic fatty liver disease (NAFLD) is currently at 25% and rising. NAFLD results from accumulation of excessive fat in the liver and covers a spectrum of disease states from simple steatosis (fatty liver) to severe non-alcoholic steatohepatitis (NASH). NAFLD patients are also at increased risk of developing secondary pathologies, including infections and paracetamol-induced liver damage, although the mechanisms behind this remain unclear. As no pharmacological treatment of NAFLD exists to date, patients are typically instructed to lose weight as this can alleviate symptoms. However, with the recent proposal of tissue memory of inflammation, including NAFLD, it is unclear if weight loss alone is sufficient to restore liver homeostasis or if recovered NAFLD patients remain more susceptible to secondary inflammatory events. Recently, the host labs have identified key cell-cell circuits that control the functional specialization of liver resident macrophages in the steady-state and fatty liver. These findings led me to hypothesize that NAFLD could lead to tissue memory by disrupting the interactions between resident liver cells and establish aberrant cell-cell circuits that maintain a pathological state even after weight loss. Furthermore, I postulate that this NAFLD memory could facilitate the relapse into NAFLD but also modulate susceptibility to secondary insults. Indeed, my preliminary data indicates altered susceptibility to paracetamol overdose. Here, I propose to use single-cell RNA sequencing and epigenetics to investigate how cell-circuits in the liver are perturbed after NAFLD regression and identify the signals underlying these alterations. This project will further our understanding on how liver circuits are distorted in disease and could provide therapeutic avenues to ‘reset’ pathogenic liver circuits in patients currently suffering from NAFLD or those in the process of weight loss and recovery.

Keywords: cell cell interactions non alcoholic fatty liver disease nafld tissue resident macrophages macrophage niche liver,kupffer cells,tissue memory,epigenetics
Disruptive, drug free treatment of knee osteoarthritis using novel materials and minimally invasive catheter delivery (EmboSure)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-05-01
End date: 2024-11-30
Duration (months): 31.0
Total project cost (EUR): 3555104.0
EU funding (EUR): 2488572.8
Participants: 1
Project status: CLOSED

EmboSure is a breakthrough treatment for Knee Osteoarthritis. It acts directly on the mechanism of Osteoarthritis, delivers long term pain relief and stops the progression of the disease for up to 5 years. The solution involves embolising or blocking the tiny blood vessels of the knee with patented bioresorbable particles developed by CrannMed. The bioresorbable embolic particles are tightly calibrated 200µm particles, made from naturally occurring biocompatible materials which block the small blood vessels of the knee over a five day period. This disrupts the osteoarthritic degradation before the particles are completely reabsorbed into the body. The particles are delivered through a minimally invasive microcatheter, specifically designed by CrannMed to reach the tortuous vessels of the knee. As the maintenance of blood supply to the knee and the lower leg is critical, the bioresorbable particles and microcatheter are key to our paradigm to treat without leaving anything behind.

Keywords: opioid addiction,pain relief,interventional radiology,genicular artery embolization
Effect of fuel composition on climate impact from aerosol-cloud interaction (PACIFIC Hop-On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Cyprus
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 28.0
Total project cost (EUR): 407467.5
EU funding (EUR): 407467.5
Participants: 2
Project status: CLOSED

The PACIFIC Hop-On project will advance understanding of aviation’s non-CO2 climate impacts by integrating the Cyprus Institute’s Earth System Modelling expertise into the ongoing Horizon Europe PACIFIC consortium. Focusing on new particle formation (NPF) from aircraft emissions in the climatically sensitive upper troposphere and lower stratosphere, the project will enhance global climate-chemistry models with state-of-the-art parameterisations informed by CERN CLOUD experiments. Using high-resolution simulations, it will quantify how aviation-induced aerosols influence cloud properties and radiative forcing, and assess the mitigation potential of sustainable aviation fuels (SAF) with different compositions. The collaboration will improve predictive capacity for EU and international climate policy, strengthen industrial innovation in aviation and fuels, and build lasting research excellence in Cyprus through capacity building, knowledge transfer and international networking.

Keywords: aviation emissions,earth system modelling,non co2 emissions,climate impact,aerosol cloud interaction,new particle formation,jet fuel composition,saf,
Children, trauma and political violence in Italo-Slovene Borderland (1945-1960) (RETROCHILD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-03-31
Duration (months): 27.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

RETROCHILD explores the (psychological) impacts of war and other forms of political violence on children (age 0-18) from a historical perspective relying on trauma and resilience as analytical concepts. Temporally, it is focused on the post World War II period (1945–1960). Geographically, it explores what is now the borderland between Italy and Slovenia, but also aims for a global perspective on the phenomena at hand. Its main objectives are to explore how the meanings surrounding the concept of childhood trauma (or resilience) were defined by different actors, ranging from the experts who worked with children affected by political violence to the children themselves and also to uncover the political motivations behind the narratives relating to and the treatment of children who were considered traumatised or psychologically damaged. In order to examine the universalisations related to the meanings and motivations behind these, the project applies a novel “retrograde approach”, which, instead of the events presumably involving psychological distress, develops the analysis from three subsequent examples of social, medical and legal interventions: the first intervention involves orphans and abandoned children (WP1), the second children in psychiatric care (WP2) and the third juvenile delinquents (WP3). RETROCHILD’s unique interlinked focus on interventions within the medical, social and criminal justice systems in the border area will reveal original insights into the nature of the experiences of war and the socialist childhood, as well as the functioning of political power. In addition to questioning the universal (Western) notions of trauma and victimhood, the project will use childhood narratives in a highly contested border region to challenge the conventional divide between socialist and non-socialist (or eastern and western) understandings of social welfare, education and mental illness.

Keywords: children,trauma,resilience,political violence,post war period,second word war,history of psychiatry,borders
MULTIPLATFORM FIELD SURVEILLANCE FOR INTEGRAL CROP HEALTH, EARLY DETECTION AND ACTUATION (CERBERUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Cyprus,Slovenia
Call: Digital technologies supporting plant health early detection, territory surveillance and phytosanitary measures (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 4891830.0
EU funding (EUR): 4891830.0
Participants: 14
Project status: SIGNED

CERBERUS will capitalize on early detection to reduce pesticide use and on intelligent spray applications to sustainably eradicate pests at their early stages, when damage is reduced and the impact of treatments is high even with low spray rates. The project will combine large-scale crop observation models enhanced by the high revisiting time and diversity of bands offered by Copernicus, with the high reliability of proximal sensing granted by IoT insect traps reporting at a daily basis, robot-based monitoring at less than 1 m from the crops, and the granularity resulting from citizen data using dedicated apps. Data coming from multiple sources will be merged through a cloud platform, which will produce risk maps and spraying recommendations for users by applying AI algorithms. CERBERUS will be the outcome of a multi-actor approach by co-creating and sharing knowledge with all the different type of actors along the whole project. Cerberus will be validated for three quarantine pests (F. dorée, X. fastidiosa, B. dorsalis) and three commonly managed pests (L. botrana, B. oleae, C. capitata), and for the three most important specialty crops in the Mediterranean basin: wine-production vineyards, olive oil producing orchards, and citrus plantations. The multi-actor approach will be strengthened by the complementarity of the consortium: three academic partners, three technology companies, one citizen science specialist, a government agency involved in crop protection, and five end-users from Italy, Cyprus and Spain, providing two pilot plots per country and target crop. The proposed concept and methodology of CERBERUS has the potential to deploy an innovative crop surveillance system, enhanced by early detection in high-value crops to firmly step ahead in the effective application of sustainable phytosanitary measures and in the co-creation of crop protection policies.

Keywords: remote sensing robot scouting iot insect trap variable rate sprayer quarantine pest specialty crop cloud computing large scale surveillance early detection pesticide maa citizen science
Artificial Intelligence using Quantum measured Information for realtime distributed systems at the edge (A-IQ Ready)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Austria,Finland,Germany,Czechia,Latvia,Lithuania,France,Italy,Netherlands,Spain,Türkiye,Portugal,Sweden,Greece,Slovakia
Call: HORIZON-KDT-JU-2021-2-RIA (HORIZON-KDT-JU-2021-2-RIA, 2021)
Start date: 2023-01-01
End date: 2026-03-31
Duration (months): 39.0
Total project cost (EUR): 33392376.22
EU funding (EUR): 10506182.08
Participants: 52
Project status: SIGNED

Global environmental issues, social inequality and geopolitical changes will pose numerous problems for our society in the future. To face these new challenges and deal with them, there is a need to understand and appropriately utilize new digital technologies such as artificial intelligence (AI), the Internet of Things (IoT), robotics and biotechnologies. A-IQ Ready proposes cutting-edge quantum sensing, edge continuum orchestration of AI and distributed collaborative intelligence technologies to implement the vision of intelligent and autonomous ECS for the digital age. Quantum magnetic flux and gyro sensors enable highest sensitivity and accuracy without any need for calibration, offer unmatched properties when used in combination with a magnetic field map. Such a localization system will enhance the timing and accuracy of the autonomous agents and will reduce false alarms or misinformation by means of AI and multi-agent system concepts. As a priority, the communication guidance and decision making of groups of agents need to be based on cutting-edge technologies. Edge continuum orchestration of AI will allow decentralizing the development of applications, while ensuring an optimal use of the available resources. Combined with the quantum sensors, the edge continuum will be equipped with innovative, multi-physical capabilities to sense the environment, generating “slim” but accurate measurements. Distributed intelligence will enable emergent behavior and massive collaboration of multiple agents towards a common goal. By exploring the synergies of these cutting-edge technologies through civil safety and security, digital health, smart logistics for supply chains and propulsion use cases, A-IQ Ready will provide the basis for the digital society in Europe based on values, moving towards the ideal of Society 5.0.

Keywords: system of systems
Hidden in the Noise: Transient Details of Nanoparticle-Catalyzed Reactions Under Challenging Conditions (NANODYNAMICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1812500.0
EU funding (EUR): 1812500.0
Participants: 1
Project status: SIGNED

Metal nanoparticle-based catalysts drive our chemical industry and will be an essential tool to shift away from fossil-resources. Despite their exigence, new catalysts are often still found by trial and error rather than designed rationally. Although recent fundamental studies from our own research and others yield important new insights, there is a lack of methodology to investigate the subtle transient details missing in our understanding at the very high pressures that are often industrially relevant. Details such as reaction mechanisms, or dynamic surface equilibria at more than 100 bar are evidently greatly relevant to rationally designing better catalysts, yet have so far been outside of the realm of experimental characterization which hampers progress. Our key objective is to generate fundamental understanding of supported metal nanoparticle catalyst dynamics at work under relevant high-pressure conditions (up to 100 bar), with a strong focus on studying the Haber-Bosch reaction. To achieve this, we will utilize three recent developments: We will (1) employ specially designed reactors where laminar flow standing wave stimulation will be used, (2) perform high-time resolution resonant-Surface-enhanced infrared spectromicroscopy, and spatially resolved quick-X-ray absorption spectroscopy and (3) use our noise classification algorithm and further statistical data mining for quantification of surface site participation, and dynamics. In this way we will be able to differentiate important but miniscule reaction details from noise. These novel methods will be combined to gain insight into dynamic active sites, and equilibria that may exist at high pressure. The new insights will shift our fundamental knowledge from ‘static approximation’ to ‘dynamic reality’ and will offer direction in a new path of activity design improvements, dynamic site tailoring.

Keywords: operando spectroscopy,high pressure experimentation
Nonergodic hydrodynamics in quantum systems (NonErgHydro)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1497422.0
EU funding (EUR): 1497422.0
Participants: 1
Project status: SIGNED

The Universe is a non-equilibrium system that cannot be fully understood by solely thermodynamics. Quantum many-body physics has emerged as a key field for exploring fundamental questions of cosmology, statistical physics, and condensed matter, serving as the foundation for the development of future quantum technologies. Contemporary experiments probe far-from-equilibrium metastable phases and realize different instances of nonergodic systems. The breakdown of canonical thermodynamics compels a reassessment of our understanding of emergent macroscopic properties of matter. Simultaneously, strong interactions and quantum effects limit conventional numerical methods to small scales or early times. The dynamics of nonergodic systems at large scale remain an underexplored frontier that demands urgent attention. The project NonErgHydro takes on the ambitious challenge of investigating nonergodic quantum systems at the macroscopic scale. NonErgHydro renounces to postulate thermodynamics and seeks to uncover how macroscopic physics emerges from the microscopic degrees of freedom. The project will extend the concepts of hydrodynamics to non-ergodic systems identifying novel phases of matter, new transport universality classes, and providing at the same time a long-sought computational framework able to supersede conventional numerical methods, by capturing quantum effects in non-linear classical hydrodynamic equations. The accomplishment of this project will significantly advance our understanding of many-body quantum systems, by answering fundamental questions in hydrodynamics and universality. NonErgHydro seeks immediate confrontation with experiments, which will benefit from the ground-breaking methodology developed by my research team and will provide new inspiration for exciting developments.

Keywords: thermalization,hydrodynamics,integrability,lattice gauge theories,monitored systems
Observational Cosmology Using Large Imaging Surveys (OCULIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2457977.93
EU funding (EUR): 2457977.93
Participants: 1
Project status: SIGNED

The current standard model of cosmology successfully describes a variety of measurements, but its main ingredients, dark matter and dark energy, are a great mystery. ESA’s Euclid satellite is the biggest step forward towards solving this fundamental problem in physics. It is designed to reveal the nature of the dark constituents and gravity by measuring the growth of structure over most of cosmic time with unprecedented precision, but the interpretation of the data is complex: incorrect modelling of the galaxy populations, astrophysical processes or instrumental effects can easily be mistaken as evidence for new physics. To fully exploit the statistical power of Euclid, the intricacies of the data need to be understood, but we also need an accurate model of structure formation that can describe the interplay between galaxy formation, astrophysics, dark matter and cosmology. OCULIS tackles both aspects by providing the best measurements of the lensing signal and using the Euclid data in novel ways to relate observed galaxy properties directly to the matter distribution. To do so, we will (i) use in-flight data to correct for instrumental biases; (ii) measure the intrinsic alignments of galaxies that contaminate the lensing signal; (iii) exploit Euclid’s unique ability to determine the lensing signal on small scales to directly determine the stellar masses of galaxies for the first time, and to study the tidal stripping of dark matter halos; (iv) use the results to inform models that describe the small-scale astrophysics in hydrodynamic simulations, yielding robust predictions of the cosmological signals. As cosmology coordinator of the Euclid mission, the PI is uniquely positioned to achieve these objectives. The synergetic approach of OCULIS exploits that Euclid is much more than a cosmology mission: it is also a prime dataset for the study of the formation and evolution of galaxies. By linking both science cases, OCULIS maximizes the scientific return of Euclid.
EuPRAXIA Doctoral Network (EuPRAXIA-DN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Hungary,United Kingdom,Czechia,Romania,Israel,Portugal,Slovenia,Austria,Sweden
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2027-07-31
Duration (months): 55.0
Total project cost (EUR): 2750008.11
EU funding (EUR): 2530360.8
Participants: 24
Project status: SIGNED

EuPRAXIA is the first European project that develops a dedicated particle accelerator research infrastructure based on novel plasma acceleration concepts and laser technology. It focuses on the development of electron accelerators and underlying technologies, their user communities, and the exploitation of existing accelerator infrastructures in Europe. It was accepted onto the ESFRI roadmap for strategically important research infrastructures in June 2021 as a European priority. To fully exploit the potential of this breakthrough facility, advances are urgently required in plasma and laser R&D, studies into facility design and optimization, along a coordinated push for novel applications. EuPRAXIA-DN is a new MSCA Doctoral Network for a cohort of 10 Fellows between universities, research centers and industry that will carry out an interdisciplinary and cross-sector plasma accelerator research and training program for this new research infrastructure. The network focuses on scientific and technical innovations and on boosting the career prospects of its Fellows.

Keywords: plasma accelerators,medical applications,beam diagnostics,plasma physics,laser physics,sensors,light sources,x ray imaging