Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MONETARY POLICY, HETEROGENEITY, AND THE HOUSING CHANNEL (HANK-w-HOUSING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2021-12-31
Duration (months): 12.0
Total project cost (EUR): 87836.64
EU funding (EUR): 87836.64
Participants: 1
Project status: CLOSED

The Great Recession has brought to light the importance of housing and household debt for the propagation of shocks in the macroeconomy. For a majority of households, owner-occupied housing represents the single most important asset in the household portfolio and is tied to the single largest liability—the mortgage. The broad objective of this project is to investigate the rich role that housing and nominal mortgage borrowing jointly play in the transmission of monetary policy. First, monetary policy induced-movements in house prices translate into consumption changes because of wealth effects. Second, a contractionary monetary shock raises the cost of borrowing which reduces the demand and as a result the liquidity of the housing market, further depressing house prices and further increases the cost of borrowing. Furthermore, nominal long-term mortgage debt implies that changes in monetary policy result in redistribution between lenders and borrowers and generate cash-flow effects that are larger for borrowing constrained households. In order to quantify these various mechanisms, we build a heterogenous agent New Keynesian (HANK) model with a frictional housing market and nominal mortgage debt. The model will be able to match the rich empirical heterogeneity in home ownership, leverage and marginal propensity to consume (MPC) across households. In particular, we aim to match the significant difference in MPC between highly leveraged households and less-leveraged ones that we document in the data. We will then use the model to answer the following questions: Is there any asymmetry between contractionary and expansionary monetary policy responses? Does effectiveness of the policy depend on the distribution of mortgage debt? How to manage a liquidity trap induced by a housing bust?

Keywords: housing,mortgages,monetary policy,heterogeneous agents,foreclosure,consumption,new keynesian
Deciphering PI3K biology in health and disease (Phd)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Spain,Germany,Spain,Germany,Switzerland,France,France,France,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-11-01
End date: 2019-10-31
Duration (months): 48.0
Total project cost (EUR): 3896148.12
EU funding (EUR): 3896148.12
Participants: 13
Project status: CLOSED

The Phosphoinositide 3-kinase (PI3K) pathway is at the core of multiple fundamental biological processes controlling metabolism, protein synthesis, cell growth, survival, and migration. This inevitably leads to the involvement of the PI3K signalling pathway in a number of different diseases, ranging from inflammation and diabetes to cancer, with PI3K pathway alterations present in almost 80% of human cancers. Therefore, PI3Ks have emerged as important targets for drug discovery and, during 2014, the first PI3K inhibitor was approved by FDA in the US for the treatment of a lymphocytic leukaemia. Nonetheless, our understanding of PI3K-mediated signalling is still poor and only a fraction of the potential therapeutic applications have been addressed so far, leaving a large amount of translational work unexplored. Europe features a set of top quality research institutions and pharmaceutical companies focused on PI3K studies but their activities have been so far scattered. This proposal fills this gap by providing a multidisciplinary network (biochemistry, mouse studies, disease models, drug development, software development) and an unprecedented training opportunity from the bench to the bedside (from pre-clinical discoveries to clinical trials), through cutting edge molecular biology, drug discovery and clinical trial organization. The proposal is aimed at training young investigators in deep understanding of the different PI3K isoforms in distinct tissues and to translate this knowledge into a new generation of PI3K inhibitors, treatment modalities and into identify new uses for existing PI3K inhibitors.

Keywords: pi3k isoforms,kinase dead mice,oncology,lipid and protein biochemistry,cell signalling,angiogenesis,immunity,endosomal trafficking,drug development,skeletal muscle disease
Cost Effective Personalised Compression Therapy for Chronic Venous Insufficiency with Accurate Pressure Delivery for Comfort and Efficacy of Treatment (ISOBAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Advanced Therapeutic Materials Limited manufacture compression stockings to treat chronic venous insufficiency (CVI) conditions, for sports recovery and to prevent deep vein thrombosis. CVI is a condition in which the blood does not return to the heart efficiently due to valves in the veins being damaged or absent. Leg ulceration, the most serious CVI symptom, is a chronic and recurrent condition causing a lack of mobility, pain and often resulting in social isolation and depression. CVI affects up to 50% of adults, 1% of Western populations will suffer from leg ulceration during their lifetime. The annual cost of the treatment of leg ulcers in Europe is estimated to be per annum €6.5bn. Standard methods of compression therapy have deficiencies relating to the ability to deliver and maintain the required pressure profile; sizing and comfort and patient compliance. Time and skill is required for effective bandaging, the cost of treatment and materials is significant over a long treatment time. Our ISOBAR stockings are manufactured using 3D scanning to create an exact limb profile, the pressure gradient is mapped to the 3D image ensuring pressure is applied exactly where needed. Algorithms convert this requirement to knitting instructions which are executed using patented yarn tension control systems. ISOBAR stockings deliver the optimal compression therapy every time they are worn. Enhanced comfort promotes patient compliance, encouraging healing and quality of life. Ulcer prevention compression can be patient self-managed delivering health service cost savings and enhancing independence. Further cost savings are achieved by reducing skilled nursing time to change dressings compared with compression bandaging for active ulcers. Patient compliance and optimal compression promotes conditions for faster healing, reducing the length and cost of treatment. Lasting more than 100 washes with no loss of efficacy means that significant material costs are also achieved.

Keywords: leg ulcers,compression,chronic venous insufficiency,3d imaging,control algorithms
Large Additive Subtractive Integrated Modular Machine (LASIMM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Belgium,France,Netherlands,Netherlands,United Kingdom,Portugal,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Novel hybrid approaches for additive and subtractive manufacturing machines (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 4868262.5
EU funding (EUR): 4868262.5
Participants: 15
Project status: CLOSED

The LASIMM project aim is to develop a large scale flexible hybrid additive/subtractive machine based on a modular architecture which is easily scalable. The machine will feature capabilities for additive manufacture, machining, cold-work, metrology and inspection that will provide the optimum solution for the hybrid manufacturing of large engineering parts of high integrity, with cost benefits of more than 50% compared to conventional machining processes. For large scale engineering structures material needs to be deposited at a relatively high rate with exceptional properties and excellent integrity. To ensure this the machine is based on wire + arc additive manufacture for the additive process. A unique feature of the machine will be the capability for parallel manufacturing featuring either multiple deposition heads or concurrent addition and subtraction processes. To facilitate parallel manufacturing the machine architecture is based on robotics. To ensure that the surface finish and accuracy needed for engineering components is obtained for the subtractive step a parallel kinematic motion robot is employed. This robot is also used for application of cold work by rolling between passes. This ensures that material properties can be better than those of forged material. A key part of this project is the development of ICT infrastructure and toolboxes needed to programme and run the machine. The implementation of parallel manufacturing is extremely challenging from a software perspective and this will be a major activity within the project. To deliver this extremely demanding and ambitious project a well-balanced expert team has been brought together. There are ten partners comprising six companies, two Universities and two research institutes. Two of the companies are SMEs and there are three end users from the renewable energy, construction and aerospace sectors. The consortium also features the whole of the supply chain needed to produce such a machine.
Ex Anatolia lux. The Linguistic Origins of Europe: Word-formation and Lexicon in Anatolian and Core Indo-European. (Ex Anatolia lux)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

The understanding of the linguistic origins of Europe begins with Proto-Indo-European (PIE), the reconstructed language from which all Indo-European (IE) languages descend, including modern languages like English, Spanish, Russian and Hindi, and are spoken by more than half of the world’s population. In particular, a proper understanding of Proto-Indo-European begins with the extinct Anatolian languages, e.g. Hittite and Lycian, known from ancient clay tablets and inscriptions and spoken in the Asian part of Turkey and part of northern Syria during 16th-2nd century BCE. The Anatolian branch plays a key role since it was the first to split off from the IE language family and has several specific features, which are not shared by other IE languages. As the first of its kind, this project will shed light on the position and development of Anatolian in relation to the rest of the IE family by a systematic study of Anatolian word formation and vocabulary. The results will integrate a ‘free access database' established 2013 by the Research Centre ‘Roots of Europe’ (RoE), which will also be a new useful research instrument for other disciplines as philology, epigraphy and archaeology in a perspective of interdisciplinary collaboration and mutual benefit. The Roots of Europe, headed by my supervisor Prof. B. A. Rasmussen (Olsen) and based at the Department of Nordic Studies and Linguistics of the UCPH, is the most appropriate institution for this project: the scientific expertise and interdisciplinary profile of the research team in the topics involved in the research, including a specific project of the IE homeland, the training and the knowledge transfer will be the winning combination not only for the achievements of the goals set up for my project, but also to make my profile as an independent researcher more competitive.

Keywords: indo european,semantics,word formation,anatolian,europe,turkey,historical comparative linguistics,suffix,lexicon,phraseology,epigraphy,archaeology,bronze age,iron age,multidisciplinarity
Services addressing the innovation management capacity of SMEs in Thuringia (INNCAS4Thuer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 43027.5
EU funding (EUR): 42748.0
Participants: 2
Project status: CLOSED

Innovation management capacity services for SMEs and key account services for beneficiaries of HORIZON 2020 SME instrument, Fast Track to Innovation - and FET open funding schemes in Thuringia

Keywords: innovation management,innovation assessment,internationalisation for smes
GasAbate N+: Additive Technology to Prevent Greenhouse Gas Emissions and to Enhance the Fertiliser and Bioeconomy Feedstock Value of Animal Manures and Slurries (GasAbate N-plus)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Ireland
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-08-01
End date: 2023-07-31
Duration (months): 36.0
Total project cost (EUR): 3540330.0
EU funding (EUR): 2478231.0
Participants: 1
Project status: SIGNED

Animal manure is a valuable resource as an organic fertilizer or as feedstock for biogas generation by Anaerobic Digestion (AD). 70% of all manure in the EU is stored for up to 6 months. During storage manure is decomposed by microbial activity, and carbon- and nitrogen-based greenhouse gases (GHG) are emitted. Loss of nutrients from decomposition results in manure becoming a less valuable resource such that: (i) farmers must buy large amounts of chemical fertiliser (ii) AD plants do not realise their potential renewable biogas output. Fertiliser purchase is the 2nd largest variable cost to EU farmers. Stored manures account for 16% of all GHG emissions from EU agriculture. Several methods have been proposed to reduce GHG emissions from stored manure but these are ineffective, costly and challenging to implement. GlasPort Bio has developed an innovative platform technology to eliminate GHG emissions from organic residues and manures that specifically inhibits methane-producing microbes and traps nitrogen, while allowing the beneficial microbial breakdown of manure solids to proceed. GasAbate N+ is GBP’s lead product in development. It is added in powdered tablet form to stored dairy and beef manures. GasAbate N+ has been independently-tested and validated in controlled trials. After 14 weeks, treated dairy manure compared with untreated: Emitted >98% less GHG Had an increased nitrogen content (> 33%) Enhanced crop yields (by 15-30%) as a fertiliser Displaced chemical fertilizers (by 29%) Increased biogas output by 38% during AD GasAbate N+ is safe, has no environmentally harmful residues and contains only food-safe ingredients. No capital or implementation costs are required to deliver this simple, cost-effective solution. Immediate economic savings are made by all users by use of the product. This EIC project proposes to complete the remaining pre-commercial and technology validation work required to bring GasAbate N+ to the point of market launch in 2023

Keywords: bio economy,circular economy,biogas,fertilizer,manure management,climate change,anaerobic digestion,ghg emissions
Innovative Chemoenzymatic Integrated Processes (INCITE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Italy,Italy,Germany,Italy,Belgium,Belgium,France,France
Call: Efficient integrated downstream processes (IA) (H2020-NMBP-SPIRE-2019, 2019)
Start date: 2019-09-01
End date: 2023-12-31
Duration (months): 52.0
Total project cost (EUR): 17405808.68
EU funding (EUR): 13223279.950000001
Participants: 9
Project status: SIGNED

The INCITE project aims to demonstrate novel integrated upstream and downstream processing paths involving flow chemistry and membrane technology in chemo-enzymatic processes. The modularity and flexibility of the developed processes will be showcased through two demonstration cases in real industrial settings and will be using hydrolases for the sustainable, safe and energy-efficient production of commodity and fine chiral chemicals. The first demonstration case involves esterase-catalyzed production of a chiral molecule used as starting material for the production of insecticides in the field of crop protection and public health, whereas the second demonstration case relates to solvent-free synthesis of oleochemical esters using lipase enzymes. Compared to traditional chemical synthesis processes, these chemo-enzymatic processes have clear advantages of greater efficiency, higher product quality and smaller environmental footprint. Their development to TRL7 will open up the way to their industrialization and thus lead to major positive economic and environmental impacts.

Keywords: chemoenzymatic processes,integrated downstream processing,commodity chemicals,fine chemicals
Feasibility of ergonomic interface for adaptive eyeglasses for presbyopia correction. (SEECLEAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Laclarée develops adaptive eyeglasses for presbyopia correction. Based on a patented technology, these eyeglasses offer presbyopes clear vision at all distances without levelling down aesthetic standards. Presbyopia appears by age 40-45 with increasing difficulties to focus at near distances and affects 400 million people in Europe, Japan and North America. Progressive lenses, featuring a vertical gradient of optical power, are today the best compromise to presbyopia correction. Still about 10% of presbyopes are very unsatisfied with these lenses, experiencing a reduced quality of life. Laclarée’s product has been designed to answer to this demand, corresponding to about 2 b€/y. Our solution relies on a disruptive fluid-filled doublet-lens activated by low-power microfluidic actuators inserted in the eyeglass arms and driven by a miniature infrared distance sensor. The lens offers a large field of view, is as transparent as any other ophthalmic lens and is compatible with most lens shapes and frame styles. Laclarée’s team is highly motivated and gathers extensive skills in optics, microfluidic and vision science. The founder of Laclarée is an experienced entrepreneur, he has successfully established a world-leading company in variable optics for cameras. The team has achieved the Proof of Concept, with a fully functional demonstrator, enabling a small scale trial with presbyopic people and raising a marked interest the ecosystem. Laclarée is preparing a seed round: a term sheet has been signed with one French and one German financial investors, discussions are ongoing with one industrial leader investor. Laclarée would like to launch a feasibility study on the user interface: mode switching between automatic and manual operations is needed and making it natural and easy-to-use is a difficult task, considering the age of presbyopes and the constraints of the product. The success of this feasibility study is crucial for market acceptance of our eyeglasses.

Keywords: presbyopia,eyeglasses,wearables,microfluidics,optics
A molecular interface science approach: Decoding single molecular reactions and interactions at dynamic solid/liquid interfaces (CSI.interface)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria,Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-06-30
Duration (months): 60.0
Total project cost (EUR): 1499750.0
EU funding (EUR): 1146875.0
Participants: 2
Project status: CLOSED

After decades of truly transformative advancements in single molecule (bio)physics and surface science, it is still no more than a vision to predict and control macroscopic phenomena such as adhesion or electrochemical reaction rates at solid/liquid interfaces based on well-characterized single molecular interactions. How exactly do inherently dynamic and simultaneous interactions of a countless number of interacting “crowded” molecules lead to a concerted outcome/property on a macroscopic scale? Here, I propose a unique approach that will allow us to unravel the scaling of single molecule interactions towards macroscopic properties at adhesive and redox-active solid/liquid interfaces. Combining Atomic Force Microscopy (AFM) based single molecule force spectroscopy and macroscopic Surface Forces Apparatus (SFA) experiments CSI.interface will (1) derive rules for describing nonlinearities observed in complex, crowded (water and ions) and chemically diverse adhesive solid/liquid interfaces; (2) uniquely characterize all relevant kinetic parameters (interaction free energy and transition states) of electrochemical and adhesive reactions/interactions of single molecules at chemically defined surfaces as well as electrified single crystal facets and step edges. Complementary, (3) my team and I will build a novel molecular force apparatus in order to measure single-molecule steady-state dynamics of both redox cycles as well as binding unbinding cycles of specific interactions, and how these react to environmental triggers. CSI.interface goes well beyond present applications of AFM and SFA and has the long-term potential to revolutionize our understanding of interfacial interaction under steady state, responsive and dynamic conditions. This work will pave the road for knowledge based designing of next-generation technologies in gluing, coating, bio-adhesion, materials design and much beyond.

Keywords: atomic force microscopy,single molecule force spectroscopy,surface and interface forces,scaling,electric double layers