Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Globalization, Visual Communication, Difference (GLOVISCOMDIFF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-04-01
End date: 2015-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In the humanities and social sciences, the rise of global capitalism has been associated with the increasing loss of difference in cultural production. Less attention has been given to how difference may be globally mobilized for symbolic and material profit. Due to the centrality of ‘design’ in the global economy, the study of visual communication industries and case studies provides a fertile and needed area of inquiry to advance the academic debate on homogenization and heterogenization in relation to cultural globalization. The proposed project will examine the significance and profitability of (social and cultural) difference, rather than sameness, in contemporary marketplaces of visual communication. Through an innovative combination of qualitative research methods, the project will: 1) identify key cases from across industries (e.g. branding, advertising, photography) and gather multiple data sources; 2) describe visual texts both syntactically and perceptually; 3) interpretively situate texts in their contexts of production, distribution and/or reception; 4) interrogate the practices of visual communication professionals; 5) critically examine the relationship between visual communication and globalization, and evaluate its linkages with power relations in contexts of advanced capitalism. The importance of this research lies in its ability to integrate the ‘micro’ perspective of textual/semiotic detail with the ‘macro’ perspective of cultural/social theory. The project will have a major impact on the state of the art by drawing attention to the cultural and economic importance of the work of visual communication professionals, who are increasingly responsible for the (re)production of social and cultural differences in everyday life. The proposed research will also enable an experienced early career researcher to transfer her work from the US to the EU, stimulate collaborative activities between the EU and the US, and develop EU-wide research partnerships.

Keywords: humanities,social sciences,cultural studies,communication,media studies,globalization,visual,difference,cultural industries
BioEnergy, Soil and Climate Change: factors and mechanisms on C storage and N2O emissions after bioenergy by-products application in soil (BESOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2013-10-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The interest in using renewable energy is continuously increasing. Biomass is the most common form of renewable energy and recently, much attention has been paid to identifying suitable biomass sources which can provide high energy outputs to replace conventional fossil fuels. An important, but little understood aspect surrounding biofuels (fuels obtained from biomass) is the overall impact on global C and N cycling. Probably the increase of energy production from biomass will lead to higher input of its by-products to the soil as amendments or fertilizers. However, it is still unclear how these novel by-products of bioenergy production will influence microbial transformation processes in soil, and thereby its greenhouse gas balance and organic matter reserves. Particular attention has to be paid to changes in the C balance of the soil and changes in N2O emission of the soil, as these may negate any benefits made by biofuel production in terms of Global Warming Potential. With this project, I aim at studying the impact of different bioenergy by-products on C and N biogeochemical cycles. The study will focus on residues from two bioenergy chains (anaerobic digestion and pyrolysis), but novel bioenergy by-products from new developing tecnologies (such as residues from third-generation biofuels from algae) will also be included at laboratory scale. C and N mineralization in soil will be followed using a combination of 15N and 13C labeling units. Dynamics of CO2 and N2O will be studied in the field and under controlled conditions (laboratory experiments). N2O emitted per unit stabilized C will be quantified. This novel ‘efficiency parameter’ for C sequestration will be related to the different properties of the biofuel by-products. The integrated results of these experiments will help to understand the impact of the different bioenergy chains on C an N cycles, which may have a high impact on life cycle analysis calculations for the different bioenergy chains.

Keywords: bioenergy,biochar,digestate,nitrous oxide,c sequestration,biotechnology,soil chemistry,soil protection,soil fertility
The growth of galaxies (PHIZ-EV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 2
Project status: CLOSED

Understanding how and why galaxies form and evolve is one of the most challenging problems in modern astronomy. Our own galaxy, the Milky Way, shows order and structure, as do most massive galaxies in our local neighbourhood. Yet when we look at very distant galaxies, which exist in the early Universe due to the time it takes their light to reach us, they are disordered and chaotic. Several theories suggest physical processes which may be responsible for this transformation, but we lack conclusive observational evidence. The last two decades has seen an enormous increase in the quantity of data on both local and distant galaxies. In the next 3 years several new surveys will be completed, providing better spatial resolution and wavelength coverage of distant galaxies than ever before. Examples are the Hubble CANDELS survey and UltraVISTA with the new European survey telescope. However, the last decade has shown that our understanding of galaxies does not necessarily advance as rapidly as data quantity and quality. The development of sophisticated methods to compare theories of galaxy evolution to observational data is urgently needed before these new surveys can be fully exploited and we can irrefutably identify the dominant physical processes driving galaxy evolution. Since the completion of my PhD in observational galaxy evolution in the UK, I have gained 5 years of experience in France and Germany in interpreting galaxy survey data with models. I have built a unique network of collaborators and range of expertise which I will bring to a focus studying high redshift galaxy evolution in my new position at the University of Edinburgh. This project will naturally join European teams with expertise in data and models. As well as ensuring that Europe continues to lead the way in galaxy modelling, the unique combination of state-of-the-art datasets and new methodology for comparison to galaxy models will lead to important progress in understanding galaxy evolution.

Keywords: astrophysics,galaxy evolution,high-redshift galaxies,multi-wavelength photometric surveys,galaxy evolution modelling
pARylation-mediated regulation of cancer pathways (PARYLOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-03-01
End date: 2013-08-08
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

Poly(ADP)ribosylation (pARylation) is an important post-translational modification of proteins that affects diverse biological processes such as DNA damage repair, apoptosis and transcription. The conjugation of Poly(ADP)-ribose (pADPr) to target proteins is mediated by members of the Poly(ADP)-ribose polymerase (ARTD/PARP) protein family. ADPr can be attached either as a single moiety or as chains forming poly-ADPr polymers (pADPr). The best-studied member of the ARTD/PARP family is ARTD1/PARP1, a DNA nick sensor enzyme that is activated following DNA damage. ARTD1/PARP1 is able to pARylate itself and a number of other protein targets, such as histones and DNA repair proteins, modulating their activity. Another member of this super-family is the telomeric ARTD/PARP, Tankyrase 1 (ARTD5/TNKS1), which plays an important role in maintaining telomere integrity, by pARylating its telomere partner, TRF1. Since the discovery that defects in homologous recombination sensitise cancer cells to PARP inhibitors there has been a renewed interest in ARTD/PARPs as attractive therapeutic targets. Furthermore, similarly to kinases and phosphorylation it seems likely that ARTD/PARPs and pARylation will have significant roles in the controls of a diverse range of cellular mechanisms. Using a combined approach of RNA interference (RNAi), drug treatment and mass spectrometry-based proteomic analysis, I propose to identify and characterise novel mono- and poly-(ADP)ribosylation targets, specific to particular ARTD/PARPs. This will help to resolve how (ADP)r conjugation regulates biological processes and contributes to the survival and maintenance of cancer cells. Moreover, using pathway specific reporter cell lines I will address the specific contribution of mAR/pARylated proteins for the regulation of several cancer-related signalling pathways. Ultimately, these studies will reveal novel and promising pARylation-based therapeutic targets for cancer treatment.

Keywords: padpr,parp,par inhibitors,cancer,anticancer therapies,rnai,breast cancer,proteomics
NEOLIBERAL_CITI: Re-framing urban neoliberalism and neo-liberal citizenship – Enactments of resistance and practices of protest (NEOLIBERAL_CITI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-04-01
End date: 2014-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The widespread proliferation of neoliberal ideology and the application of its central principles to urban development can be portrayed as key aspects that introduced major modifications in the ways urban politics are conceived today. Such transformations do not exclusively apply to the political sphere – neoliberalism has also affected the habits of how people imagine, perceive and appropriate urban spaces in their daily life. Cities play a strategic role in the variegated geographies of neoliberalism, but relatively little research critically assessed conceptually the challenges democracy faces in neoliberal societies. The interdisciplinary research project NEOLIBERAL_CITI will tackle this gap – it investigates the discourses and practices of contest and re-appropriation of urban space, thus providing a novel understanding of how opposition against neoliberal urban development and neo-liberal citizenship is being re-framed after the recent financial and economic crisis. Against the background of the application of innovative qualitative methodologies such as reflexive photography and biography-oriented narrative interviews, the project aims at advancing theoretical debates within citizenship studies and urban geography as well as at producing new empirical insights to the broader implications of urban neoliberalism. The design of the research project responds to the sound embedding the applicant has within areas such as critical urban research, social theory, citizenship studies and human geography. Additionally, he is a recognised expert for the implementation of qualitative empirical research. The development of NEOLIBERAL_CITI gives him the opportunity to constitute an independent research group about neoliberal urbanism and neo-liberal citizenship at his host institution. Such an aim responds both to the position of professional maturity and the long-lasting professional stability he was recently offered.

Keywords: social sciences,human geography,political geography,urban geography,urban sociology,political science,citizenship,neoliberalism,local political conflicts,critical geography,visual sociology
Direct Imaging of Extrasolar Planets from LBT and VLT to E-ELT (DICE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-03-01
End date: 2015-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The direct imaging of planets around other stars has begun in earnest. The main challenge in imaging these faint companions is the large contrast between star and planet. By using a combination of adaptive optics, coronagraphs, thermal wavelength imaging and point spread function modeling, current ground based telescopes can search closer to target stars for extrasolar giant planets. The applicant proposes to continue his current exoplanet surveys using the facilities at Steward Observatory (the Large Binocular Telescope, LBT) and European facilities (the ESO Very Large Telescope, VLT) and characterize new discoveries with spectroscopy. In moving to Leiden, the applicant will use the resources to develop these exoplanet detection techniques, and start a project with a PhD student partly funded with this reintegration grant to measure the ground layer atmospheric turbulence at high telemetry rates for further analysis. By providing real world data for European Extremely Large Telescope (E-ELT) adaptive optics simulations, the performance of next generation of exoplanet instruments will be increased.

Keywords: astrophysics,extrasolar planets
Atypical Works in Pre-Industrial Europe. Pluriactivity, Mobility and Social Identities (ATYPICALWORKPATTERNS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-11-01
End date: 2015-03-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The aim of this project is to investigate atypical forms of work (professional mobility - moving from a job to another-, temporary works, pluriactivity) in pre-industrial Europe. By using a micro-analytical approach, and focusing on individuals, their biographies and career paths, the project aims at shedding a new light on the preindustrial European labor market, and to identify and describe “atypical” patterns of work. The project has the final goal to demonstrate that work, in present and past societies, was a complex social resource, that individuals manipulated/handled in a framework made of individual and household’s life-cycle, conflicting sets of rules, juridical frameworks, social networks and contexts, flexibility. Beside showing the complexity of work as resource, the aim of this proposal is to identify and describe patterns of atypical work, with a strong micro-analytical approach. to this purpose, the research will be carried out on the following topics: 1. Patterns of pluriactivity and other atypical works; 2. Alternative accesses to the labor markets; 3. The relation between professional and geographical mobility. The research will be entirely carried out on primary sources. The survey will go through a series of case studies which mirror different patterns of atypical work, in France and in Italy. To this purpose, the research will have a strong micro analytical approach, focusing on individuals and making an extensive use of biographical data. The subject of flexibility in the organization of work is a living matter: the project will be an important contribution to understand how individuals of the past societies coped with periods of crisis, unemployment and impoverishment processes, but also how work was used to enhance processes of social mobility. For this reason, the project will be of the greatest importance and utility for the European Community, and it will be a major contribution to EU scientic excellence.

Keywords: work,mobility,pluriactivity,europe,social identities,social history,pre-industrial,labour market
THE GLUCO- AND MINERALO-CORTICOID PATHWAYS IN RETINA: MOLECULAR CARACTERISATION AND THERAPEUTIC IMPLICATION (GLUCOMINERALORET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-05-01
End date: 2014-12-24
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Considering the alarming rate of diabetic patients becoming blind after retinal edema formation, and the important risks of ocular complications due to the low specificity of the current glucocorticoid (GC) treatment, it is imperative to bring together all the necessary means for the development of novel therapies with better specificity, efficiency and limited secondary effects. To that end, it is crucial to fill the gap in the fundamental knowledge of diabetic macular edema (DME) physiopathology. By taking advantage of an existing beneficial but imperfect anti-edematous therapy (low specificity), we propose to use state-of-the-art methods to perform a wide and unique study on the mechanisms i) involved in diabetic retinopathy ii) and regulated by the corticosteroids, with the aim to potentiate the therapeutic effect of GCs, for a real restoration of vision in DME patients.

Keywords: health sciences,molecular biology,biotechnology,retina,corticosteroid,diabetes,edema,genome-wide technologies,next generation sequencing,nuclear receptor
Title: Self-Renewal, Fate Potential and Plasticity of Human Embryonic and Induced Pluripotent Stem Cell-Derived Neural Stem cells (MODNEURDEVDIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Neural stem cells (NSCs) can propagate in vitro while retaining ability to differentiate into neurons, astrocytes and oligodendrocytes. However, because of the nature of their developmental progression, NSCs isolated at different developmental stages or regions exhibit remarkable differences in their ability to yield specific neuron types. Specifically, NSCs grown in vitro rapidly lose access to the full neuronal spectrum. Limited NSC potential is one of the major impediments for applications in regenerative medicine, specifically for Parkinson’s and motoneuron-related diseases. Therefore, there is an enormous need to understand how NSCs self-renew. Human embryonic stem cells (hESCs) are known to provide access to early neural fates. We have recently isolated a novel type of early NSCs derived from hESCs termed rosette-NSCs (R-NSCs), which respond to such regional patterning cues. We proved the unique NSC stage of R-NSCs based on their cytoarchitecture, marker expression, stem cell properties and differentiation potential. Nevertheless, we only partially identified growth requirements and signaling pathways governing the R-NSCs stage. Here we would like to address these limitations by defining heterogeneity within R-NSCs and develop genetic strategies to prospectively isolate fully patternable R-NSCs. Generating transgenic hESC reporter lines will serve as reliable readout for defining R-NSC stage, identity and function, and will be used for establishing correlative genome-wide chromatin state and promoter methylation maps. Finally we will systematically probe function of extrinsic/intrinsic factors affecting R-NSC identity, neural patterning potential and epigenetic state. This should provide fundamental insights into the genetic/epigenetic mechanisms of neural patterning and ultimately result in novel conditions for the continued in vitro expansion of fully patternable R-NSC - a key step towards establishing a stable expandable universal NSC population.

Keywords: neurobiology,stem cell biology,human embryonic stem cells,neural stem cells (nscs),induced pluripotent stem cells,neural rosettes,nsc potential,modeling neural development & degeneration