Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Electronic Response of Single Inorganic Nanowires (ERESIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Slovenia
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-11-01
End date: 2011-10-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Nanoscale integrated electronics requires building blocks with controlled functional properties. In the continuous strive towards higher integration density, an alternative way of connecting transistors inside a chip is needed. Tertiary inorganic nanowires made up of molybdenum, sulphur and iodine (MoSI) provide a straightforward, scalable synthesis and easy dispersability in a variety of solvents without functionalisation or surfactants. Their connectivity to gold nanoparticles enables self-assembly of networks. To date, their conductivity is limited by energy disorder and defects. This process aims at improving the material by investigating the origin of disorder and defects. To this end, both the basic electrical characterisation as well as the study of the electronic relaxation dynamics via femtosecond spectroscopy will be performed with a spatial resolution down to the individual nanowire. Defects in isolated small nanowire bundles, single nanowires, and networks will be identified with conductive atomic force microscopy. Femtosecond pump-probe spectroscopy using a confocal microscope will be performed on the same samples in order to study the electronic processes of individual nanowires and how they change in the presence of defects and nanoparticle junctions.

Keywords: inorganic nanowires,electronic properties,femtosecond spectroscopy,confocal microscopy
Evaluation of epigenetic biomarkers in prostate cancer patients before and after hormone ablation therapy (EPIGENETIC MARKER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-11-01
End date: 2012-10-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Prostate cancer is among the leading tumor types in men in the Western world. The heterogeneity of prostate cancer provides difficulties in tumor classification and decision-making for therapies. The establishment of new biomarkers is essential to develop individual treatments and facilitate tumor categorization. Therapies include hormone deprivation, which initially leads to tumor regression, but is associated with a high rate of recurrence. Both genetic and epigenetic alterations have been found in prostate cancer. Especially overexpression of the Polycomb protein EZH2 has been associated with aggressive tumors and bad prognosis. Additionally, DNA methylation of various genes including tumor suppressors, hormone receptors or cell cycle regulators has been described. Here we aim to investigate epigenetic patterns in human prostate cancer tissues before and after hormone ablation therapy, to evaluate novel biomarkers and to identify novel target genes of epigenetic mechanisms. We intend to monitor changes in epigenetic marks such as DNA methylation and Polycomb protein occupancy in prostate cancers before and after hormone deprivation. Furthermore, we aim to test our previous results obtained in prostate cancer cell lines to learn more about the clinical significance of epigenetic mechanisms in prostate cancer. The use of epigenetic drugs, such as DNA methyltransferase inhibitors and histone deacetylase inhibitors has been approved by the US food and drug administration for the treatment of specific hematological malignancies, and clinical trials have shown the beneficial effects for several tumor types. Thus, our study may elucidate novel molecular mechanisms of the disease and provide a rationale for the application of epigenetic drugs to target prostate cancer.

Keywords: health sciences,cancer research,epigenetics,prostate cancer
Modulation of the Notch receptor activity through the regulation of the epithelial apical-basal polarity in Drosophila melanogaster (NOTCH AND POLARITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Several lines of evidence suggest an interplay between apical-basal polarity (ABP) and Notch (N) signaling in epithelia. Available data indicate that modulation of N signaling can occur through both direct regulation of the activity and mislocalization of either the receptor or the ligand. The purpose of this project is to understand how N activity can be modulated by differential regulation of apical-basal components or, in general, subcellular domains. A genetic screen among genes involved in ABP, ranging from regulators of vesicular trafficking or protein sorting to polarity regulators themselves, will help us identify the components underlying this modulation. Further genetic analysis together with molecular biology and biochemistry studies will help understand the molecular mechanisms of N activity modulation by ABP. Both ABP regulators and N pathway members have been shown to be involved in crucial events during development and tissue homeostasis, such as control of epithelial integrity and cell division, that, when distorted, can lead to tissue overgrowth and eventually cancer. Nevertheless, the molecular mechanisms underlying these processes are very poorly understood. This project will help shed light on these mechanisms.

Keywords: developmental biology,cell biology,intracellular trafficking,intercellular signaling,notch
Regulation and function of the E3 ubiquitin ligases Muscle RING finger 1 and 3 in cardiac hypertrophy (MURF AND HYPERTROPHY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Heart failure caused by cardiac hypertrophy is a growing epidemic and remains the most frequent cause of hospitalization in elderly patients in the European Union. However, molecular mechanisms leading to cardiac hypertrophy and its transition into heart failure are poorly understood. Maintenance of cardiac structure and function requires a precise control of protein synthesis and degradation; abnormalities in these processes can give rise to myopathies. The protein degrading ubiquitin proteasome system (UPS) and its muscle specific key enzymes Muscle RING finger (MuRF) 1 and 3 are activated during cardiac hypertrophy and heart failure. MuRF1 and 3 are essential for the degradation of structural proteins, such as myosin heavy chain (MHC), leading to a decrease in cardiac function and heart failure. MuRF inhibitors are therefore expected to prevent transition of cardiac hypertrophy into failure. This proposal aims to investigate the function and regulation of MuRF1 and 3 during cardiac hypertrophy. More specifically, the major hypothesis that the function of MuRF1 is mainly mediated through its E3 ubiquitin ligase activity will be investigated. First, the specific cysteine residue within the RING-finger of MuRF1 responsible for its E3 ubiquitin ligase activity will be identified. This residue will than be germ-line mutated and the hypertrophic response of mice lacking MuRF1s E3 ligase activity will be analyzed following aortic banding. Secondly, the domains within MuRF proteins mediating MuRF binding to their MHC target proteins will be investigated. Additionally, we aim to analyze if hypertrophic stimuli can regulate binding between MuRF1 and 3 and their target proteins. Finally, a cDNA expression screen will be employed to discover novel transcription factors and signal transduction pathways regulating MuRF1 expression during hypertrophy. Furthermore, our preliminary data showed that the MuRF1 promoter can be activated through the muscle-specific transcription fac

Keywords: cardiology,hypertrophy,heart failure,ubiquitin proteasome system,ring finger e3 ubiquitin ligase,transcriptional regulation
Thick Evaluative Concepts: Value, Reasons, and the Natural World (THICK VALUE CONCEPTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Developments in linguistics and metaphysics open unprecedented opportunities for advances using up-to-date methods from these areas in metaethics: an area of moral philosophy that studies these topics as they arise with respect to normative issues. The proposed research is a full-scale study of “thick” evaluative concepts, led by the coordinator of this proposal and building on his US work with such methods in metaethical study of general moral principles and their role in moral knowledge and guidance. The goal of the proposed work is to enable the coordinator to transition his methods to new work on thick value concepts and establish himself in European context. The project is unique in using up-to-date work in linguistics on gradable adjectives to analyse the meaning of evaluative language, focusing on concepts that are “thick” in that they combine evaluation with robust natural non-evaluative conditions on their applicability (e.g. 'cruel', 'honest'). It will determine whether these elements of thick concepts decompose and so whether there is any basis for a robust fact-value distinction. It will investigate whether thick value judgements express beliefs that can be true or false or non-cognitive sentiments that cannot, and whether thick concepts correspond to real properties in the natural world. The project's innovative methodology, and the new perspectives and results it enables, will have a major impact on the state of the art. The project is timely and humanly relevant, especially given the role thick concepts play in moral disagreements that reflect cultural and social differences. The proposed project enables the reintegration of a world-class, experienced European researcher. It is designed to stimulate interaction and collaboration among US and European researchers, and is fully aligned with the coordinator's forthcoming senior, long-term role at a major UK host organisation, the University of Leeds, so as to secure a strong knowledge transfer path.

Keywords: humanities,philosophy,ethics,moral philosophy,metaphysics,linguistics,semantics
TRACING IDENTITY IN THE EASTERN MEDITERRANEAN; A Digital Survey of Late Medieval Monuments in the Eastern Mediterranean Islands (TIEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Cyprus
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-06-01
End date: 2013-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This project proposes the interdisciplinary examination of the monumental heritage of the Medieval Mediterranean. Specifically, the program’s objective is the creation of a comprehensive digital repository of the late medieval monuments of the islands of the Eastern Mediterranean using state-of-the-art technological tools. Research will cover the eastern part of the Mediterranean basin beginning with Cyprus, Rhodes and Chios to be progressively extended to Crete and other Aegean islands. The program offers a novel methodology that adjusts to the complex socio-political realities of the Medieval Mediterranean. Research focuses on the understudied period that followed the collapse of the Latin kingdom of Jerusalem in 1187 until the capture of Crete by the Ottomans in 1669. In this volatile environment, Cyprus, Chios, Rhodes and Crete became Europe’s gateways to the East; as such, they will be the central examples of this study. These islands will not be isolated studies but the pivotal mirrors to explore the region. The proposed methodology offers three levels of analysis starting from the broader geographical bodies and their location in the region, then moving to the specific locales, to finally study individual monuments. The application of informatics, GIS technologies, the use of digital libraries, and the utilization of scanning and CAD technologies will offer an invaluable record of extant architectural and archaeological remains. The in-depth documentation of surviving monuments in the above islands will be followed by the comparative examination of physical evidence against textural sources and the historical background of the period. Hosted by the Cyprus Institute, the proposed program traces aspects of the formation and appropriation of social and religious identity in the Medieval Mediterranean. This is a topic of great contemporary relevance for the EU as it offers an enhanced understanding of the intricate cultural realities of the broader region.

Keywords: humanities
RESEARCH ON LOCATION ESTIMATION IN MULTI-CARRIER SYSTEMS (REALMARS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-07-15
End date: 2011-07-14
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Multi-carrier (MC) transmission, in particular orthogonal frequency division multiplexing (OFDM), is employed in various systems mainly due to its robustness. In particular, with the deployment of WiMAX (and the upcoming LTE) systems, research in OFDM hastened. In OFDM systems, smart antenna systems with multiple transmit and receive antennae and location estimation are likely to be an area of interest. In recent years, adaptive antennae and array processing greatly impacted the performance of wireless communication systems. Also, location based services are gaining importance everyday increasing the need for better location estimation algorithms. In this work, we propose to investigate one of the most essential issues of adaptive antenna systems: the estimation of angles of arrival (AOA) for OFDM systems and its utilization in location estimation and development of location based services. The main advantage for location estimation using angles compared to distance (timing advance) is that instead of three reference points, only two reference points are sufficient. In our work, we propose to use basis selection (BS) algorithms, namely the matching pursuit (MP) algorithms for AOA and location estimation, by exploiting the sparsity property of AOA for OFDM. The main advantages of applying BS algorithms to this estimation problem are the decreased complexity and increased resolution. When OFDM systems are compared to single carrier systems in terms of AOA estimation, the main advantage is that for each subcarrier, the received phase depending on the angle of arrival is different. This results in diversity in the angle of arrival equations. In this work, we will also concentrate on the advantage of this diversity and its improvement on the accuracy of location estimation systems as well as the location based services that can be developed based on the obtained accuracy levels.

Keywords: radio engineering,ofdm,lte,wimax,angle of arrival,location estimation,location based services,basis selection algorithms,matching pursuit,multicarrier systems,multi antenna systems,mimo
Structural insight into auto-ubiquitylation as a regulatory mechanism for protein trafficking (AUTO-UBIQUITYLATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The cell interprets the information conferred by ubiquitin (Ub) through Ub-receptors, proteins that harbor ubiquitin-binding domains (UBDs). Ub-receptors can be found in three mutually exclusive forms. Apo is the unbound form, whereas trans is the intermolecular form bound to ubiquitylated cargo. Intriguingly, the third form, cis, is of Ub-receptors that are themselves ubiquitylated. Monoubiquitylation of the Ub-receptors imposes an auto-inhibitory conformation, rendering them unable to bind ubiquitylated cargos, and thus providing an intrinsic regulatory mechanism. While several structures of apo and trans are available, a cis structure form of an ubiquitylated Ub-receptor has yet to be determined. Determining a cis structure is crucial for understanding the molecular mechanism of auto-inhibition. Due to the action of deubiquitylating enzymes, the ubiquitylated form of the Ub-receptors is labile and therefore it is difficult to purify them from eukaryotes. To fill this gap in knowledge, we developed a novel bacterial system for protein ubiquitylation. The system produces a high yield of ubiquitylated protein that can be easily purified and subjected to crystallization trials. Using this bacterial ubiquitylation system, we will determine cis as well as apo and trans structures of Ub-receptors. Guided by comparison of the structures, point mutations will be introduced into key residues. In vitro functional studies including the determination of oligomeric stages, and affinity measurements using isothermal titration calorimetry and analytical ultracentrifugation will be performed on all three forms. Finally, the phenotype of the wild type and mutant proteins will be studied in vivo by monitoring trafficking of GFP-cargo under confocal microscopy. The outcome of this study is predicted to provide the molecular principles of ub-receptor regulation, and serve to design drugs for diseases that involve the monoubiquitin pathways such as AIDS and cancer.

Keywords: cell biology,biochemistry,functional biology,structural biology
Orientation of Carbon Nanotubes in Polymer Composites (ORITUPOCO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Slovakia
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Proposal plans to prepare well-aligned carbon nanotube (CNT)/polymer composites. The orientation of CNTs will be reached by two ways. By the first way, well-dispersed surface modified CNTs in gel network will be uniaxially stretched and then cross-linked further, to freeze to the oriented system. By the second way, CNTs with photo-active groups at surface will create self-assembled structures in polymer matrix. For this reason, it is necessary to perform surface modification of CNTs. It will be achieved by introducing of functional groups or oligomers miscible with polymer matrix to reach the best compatibility or by introducing the photo-active groups. Author believes that during self-assembly process of photo-active groups attached at nanotube surface they will induce the orientation of CNTs by light. Similar procedure with photo-active groups can be use in case of alignment by uniaxial stretching. For fixation of anisotropy after stretching the photo-active groups can be used again when oriented structure of CNTs is fixed by photocoupling and/or photocrosslinking at different stage of uniaxial stretching. The photocoupling or photocrosslinking produces strong chemical bonds that fix the internal structure of filler inside matrix. In addition the alignment can be affected by concentration of photo-active groups or used light. An influence of various wavelength, irradiation dose and type of polymer matrix on the orientation of CNTs and influence on mechanical and electrical properties of final CNT/polymer composite will be studied. Various optical, mechanical and electrical methods will be used for characterization of prepared composites. All data will be collected at various irradiation doses in order to be able to determine the photo-actuation behavior of composites.The ambitious goal of the proposal is photo-actuation of prepared CNT/polymer composites associated with new functionalization of CNTs.

Keywords: carbon nanotube,polymer,composite,orientation,actuation