Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Janus Graphene supported Single atom catalysts for ultrasensitive cytokine point of care sensors (RESPONSE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia,Spain
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 2
Project status: CLOSED

Cytokines, such as TNF-α, hold immense significance as protein biomarkers, pivotal for diagnostic, prognostic, and therapeutic management across various clinical disorders like Alzheimer’s disease, sepsis, and cancer. Nonetheless, prevailing techniques like enzyme-linked immunosorbent assay (ELISA) and Polymerase Chain Reaction (PCR) prove to be expensive, time-intensive, and reliant on specialized personnel, intricate instrumentation, and infrastructure. Furthermore, the performance of present biosensing techniques necessitates refinements in terms of real-time outcomes, sensitivity, affordability, and user-friendliness. Within this context, the RESPONSE project sets out to forge an innovative approach, intertwining Janus graphene derivatives (JGDs) and Single Atom Catalysts (SACs), or atozymes, for Point-Of-Care (POC) biosensors for cytokine detection. This undertaking involves the strategic utilization of selectively and densely functionalized JGDs, serving dual roles: i) as signal transducer immobilized on a paper lateral flow electrochemical sensor (LFES), and carrying the cytokine bioreceptor (primary/capture antibody; Ab1) and ii) as signal amplifier JGDs, housing the SACs and the secondary/signal antibody (Ab2), which binds to a different epitope of cytokine. The binding between TNF-α and JGDs-Ab1 initiates the sandwich formation with SAC-JGDs-Ab2 complex at the test region. Here, the SACs catalyze the oxidation of an appropriate reporter molecule, liberating electrons and thereby significantly amplifying the signal output which can be quantified through an integrated electrode system. REPSONSE offers affordability, point of care readiness and commercialization potential. Importantly, RESPONSE’s strategy defines the blueprint for transitioning from the current, symptom-focused and late-stage diagnosis to the next-generation prognostic biomarker-guided preventative or therapeutic treatment management, and improve life-quality of millions of people worldwide.

Keywords: atozymes,janus graphene,bioreceptors,electrochemical sensor,microfluidics,cytokines
The collaboration with OER STEM learning materials. Combine benefits for all users with different feature needs to take away OER challenges, and lower the cost for real adaptive personal learning. (GraspleSTEM duolingo)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 1100000.0
EU funding (EUR): 1100000.0
Participants: 1
Project status: SIGNED

Grasple aims to transform maths and statistics education, focusing on sustainability, accessibility, and high quality. Their approach involves a community-driven solution, ensuring the platform's longevity and impact are not reliant on a few individuals. The business model targets institutions, offering paid features specifically beneficial to institutional education, while maintaining free access for individual learners and teachers. This strategy promotes inclusivity and accessibility, removing financial barriers and offering open-license content accessible on various devices, even on older phones with slow internet connections. The platform emphasizes high-quality education through an easy-to-use editor, enabling educators with maths and statistics expertise to create interactive exercises without needing coding skills. It also encourages collaborative improvements and features AI and machine learning to provide personalised feedback and adaptive learning paths. Grasple's appeal to the EIC lies in its potential to enhance maths and statistics skills across the EU, not just for students in education. The platform addresses the challenge of these subjects being a "stumbling block" for many, transforming the struggle into mastery – hence the name "Grasple". Its scalability is vital in a context of decreasing teacher numbers and increasing learners, paralleling the benefits seen in open science. As a social enterprise, Grasple has already generated revenue, showing its viability. The EIC's investment would facilitate the expansion into broader learner and educator engagement. Aligning with EU goals of increasing the number of highly educated individuals and the need for technically skilled workers, Grasple focuses on EU-wide cooperation, with a global outreach as a future objective. The funding would balance the interests of three stakeholders - learners, teachers, and institutions.

Keywords: mathematics and statistics,open education,interoperability,adaptive learning infrastructure,sustainable accessibility for high quality maths stats education,online learning,personal learning
Europe’s Ethnoschism. Nordic Manliness vs Latin Glamour, 1914-1929 (ETHNOSCHISM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

ETHNOSCHISM traces an ambient, diffuse but influential ethnotype, that of a manly, rough-hewn North vs. a frivolous, charming South – the former framed in terms of its ‘Germanic’ ethnolinguistic roots, the latter as ‘Romance’ or Latin. It analyses the widely-ramifying discursive diffusion of this ethnotype in its continuing ‘banal’ presence as a frame for social and political relations. The subject is highly topical, raising the still-burning issue of national intra-European divisions in terms of imputed ‘national characters’ by going it back to the years of their crystallisation (1914-1929) and studying the impact of cultural representations have in the political prejudices and ideologies. ETHNOSCHISM develops a new, interdisciplinary theory of the European North-South-opposition by studying its conceptual history from a radically interdisciplinary basis, combining the latest insights in 3 related specialisms in the culture-historical Humanities: imagology, the history of knowledge production (namely in racial theorizing), the intellectual history of European nationalisms. It studies ethnotypes in a completely new and original way, using them as a common discursive factor in the cultural field of representations and the political history of international relations. The methodological toolbox includes methods and approaches from different disciplines: the transnational and interdisciplinary history of national thought, Discourse Historical Approach, Imagology. The outputs include: two articles, a commented anthology, an edited book; two academic workshops. Measures to communicate the project activities include a website on the project, a temporary exhibition, the creation of an Educational Package for secondary-school students. Research and training activities at the Dept. of European Studies (UvA) will directly benefit my career prospects, equipping me with new skills and knowledge, and placing me at the forefront of the field as an interdisciplinary researcher.
next-Generation driver-vEhicle interactioN: real-tIme mUltimodal take-over control System (GENIUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2027-03-31
Duration (months): 30.0
Total project cost (EUR): 215937.6
EU funding (EUR): 215937.6
Participants: 3
Project status: SIGNED

In the midst of the automation revolution, the GENIUS project confronts a critical challenge, ensuring the seamless transition from autonomous to manual control, referred to as driver take-over control (TOC), within conditionally automated vehicles (CAD). As automation reshapes the transportation landscape, prioritizing safety during TOC is paramount. GENIUS introduces an innovative, real-time, multimodal interaction system tailored to optimize both the time and quality of TOC, leveraging biometric sensors to gauge driver readiness, awareness, and physiological status. This adaptable system dynamically adjusts TOC using interaction modalities while tailoring the experience to the unique characteristics of individual drivers. Beyond its immediate applications, GENIUS holds the potential to enhance TOC in higher levels of vehicle automation. Through the integration of advanced machine learning techniques and comprehensive experiments within a sophisticated driving simulator, GENIUS seeks to redefine TOC prediction in a wide range of real-world driving scenarios. Embracing an interdisciplinary approach, the project collaborates with experts in psychology and the automotive industry, ensuring a comprehensive and effective solution. GENIUS represents a significant leap forward in driver safety and experience in the age of automation, contributing to a safer and more efficient future on our roads.

Keywords: conditionally automated vehicles,take over control,human machine interface
Contribution of Lipid Droplets to the pathogenesis and chemoresistance of Acute Myeloid Leukemia (ALERT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 2
Project status: SIGNED

Acute Myeloid Leukemia (AML) results from the uncontrolled expansion of differentiation-defective hematopoietic stem/progenitor cells or immature myeloid cells (blasts) in the bone marrow (BM). AML remains a high-risk disease mainly due to treatment refractoriness which is dependent on leukemia-BM stroma interactions. Unfortunately, treatments have only experienced minor developments over the last decades. On the other hand, emerging evidence in cancer metabolism has identified Lipid Droplets (LDs, cytosolic fat storage organelles) as key regulators of lipid metabolism and signalling in cells exposed to stress such as hypoxia, chemotherapy, and nutrient deprivation. However, the precise role of LDs in the pathogenesis and chemoresistance of AML remains poorly investigated. Here, we aim to i) characterize the accumulation and role of LDs in AML, ii) assess the functional impact of blasts- and BM stroma-LDs on AML pathogenesis and chemoresistance, and iii) investigate the involvement of LDs in the progression and refractoriness of AML. Cutting-edge in vitro (AML primary cells, BM-stroma cells) and in vivo assays (patient-derived xenografts) will be used to provide evidence of LDs as a key player in leukemogenesis. Our project is based on solid preliminary single cell-RNA sequencing data indicating that LDs are highly accumulated in AML blasts, and that inhibition of LDs is more effective than the standard-of-care chemotherapy in impairing AML cell proliferation. Our proposal represents an innovative approach achievable thanks to the complementary knowledge and expertise of two top-notch laboratories in acute leukemia (supervisor) and LDs (collaborator). Results from this study will open new avenues to explore the therapeutic opportunity of LD inhibitors as anti-leukemic co-adjuvant. This fellowship will enable me to acquire transformational knowledge in leukemia metabolism and will constitute a major first step towards initiating my independent academic career.

Keywords: lipid droplets acute myeloid leukemia chemoresistance perilipins
Volatile dynamics and regolith interactions on solar system bodies (VOLARIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499856.0
EU funding (EUR): 1499856.0
Participants: 1
Project status: SIGNED

Over the recent decades, several remote observations have provided evidence for water on the Moon. Due to the lack of in-situ measurements, the nature of lunar water is not yet sufficiently understood. Open fundamental questions include the origin and form, spatial distribution, temporal variation, transport processes, and surface interactions. In VOLARIS, I will employ a novel modelling and experimental approach to address these questions and characterise their main influencing factors. I will specifically study the combined physical, chemical, and thermal processes across the exosphere, surface, and subsurface that govern the dynamic behaviour of volatile water. These investigations will be similarly relevant to other species such as hydrogen, hydroxyl, and noble gases and will significantly advance our understanding of the volatile dynamics of many atmosphere-less celestial bodies. Current models are not capable of simulating the complete volatile cycle with the respective source, sink, loss, conversion, and transport processes, mainly due to the computational complexity and the different physical scales. I will develop a unified model framework to enable more comprehensive simulations across different model domains and scales to systematically investigate the sensitivities to key parameters. With a novel experimental setup, I will reproduce coupled processes of the lunar water cycle in an analogue environment to investigate volatile transport and interactions emerging from a combination of multiple factors. These include complex formation and release processes and temperature-driven migration and redeposition of volatiles. VOLARIS will enable ground-breaking research on the volatile dynamics of atmosphere-less celestial bodies and is highly relevant to fundamental solar system science, future missions and instrument developments, the preservation of volatiles in their natural environment, as well as the potential utilisation of volatile resources.

Keywords: volatiles,water,exosphere,regolith,heat and mass transfer,celestial bodies
Thermal Magnetic Resonance-based Ablation Cancer Therapy (MR-ACT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-08-01
End date: 2027-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The MR-ACT project will develop Thermal Magnetic Resonance-based Ablation Cancer Therapy, a groundbreaking non-invasive approach that eliminates the need for invasive needle electrodes or fibre optic Laser probes in cancer ablation procedures. Building upon innovations from our ERC Advanced Grant ThermalMR, we will advance our proprietary high-density radiofrequency (RF) applicator technology to achieve ablative temperatures (>60°C) for tumour tissue destruction while maintaining millimetre-precision targeting and comprehensive MRI-based monitoring. Current radiofrequency or laser ablation approaches require invasive needle or fibre optic probe insertion, causing collateral damage, risking tumour seeding, limiting treatment to accessible anatomical locations, and increasing healthcare costs through hospitalization requirements. MR-ACT addresses these limitations by integrating diagnostic imaging, thermal treatment, temperature measurement and therapy monitoring in a single device without physical penetration of the body. This 18-month project will systematically refine the RF applicator technology for ablation temperatures, validate performance in anthropomorphic phantoms mimicking clinical scenarios, develop comprehensive IP protection and regulatory strategies, analyse market opportunities, and create a detailed commercialization roadmap. The technology enables treatment of previously inaccessible tumours, reduces procedural complexity, potentially enables outpatient treatment workflows, and improves patient experience while reducing healthcare costs. MR-ACT represents a high-risk, high-gain opportunity to fundamentally transform cancer treatment approaches. Our innovative non-invasive ablation technology could expand treatment options for patients with limited alternatives, establish a new paradigm in interventional oncology, and create significant commercial opportunities through technology licensing or spin-off company formation.
Complex Exciton Dynamics in Materials: a First-Principles Computational Approach (CompExDyn)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-02-01
End date: 2027-01-31
Duration (months): 60.0
Total project cost (EUR): 1700000.0
EU funding (EUR): 1700000.0
Participants: 1
Project status: SUSPENDED

Understanding the energetics and dynamics of excited states formed by light-matter interactions is essential for applications across optoelectronics and photophysics. In systems of reduced dimensionality, strongly-bound excitons serve as the main energy carriers, with long diffusion and relaxation lifetimes. As exciton dynamics are coupled to optical selection rules that stem from the atomic structure, enhanced exciton transport efficiency can be achieved through local structural modifications, such as atomic impurities and interface design, as well as crystal fluctuations. Yet current theories lack a predictive description of the underlying interactions due to such structural modifications, highlighting the need for new tools that can capture these complex exciton dynamics. Taking advantage of ever-growing computational frontiers, in this ERC project, we will derive and apply a new theoretical approach, based on the predictive many-body perturbation theory, to compute exciton dynamics as a function of structural complexity in emerging materials. We will derive and examine our approach on three emerging excitonic systems of reduced dimensionality: organic molecular crystals, layered transition metal dichalcogenides, and two-dimensional hybrid perovskites [Obj.I]. As proof-of-concept, we will use our theory to study the effect of atomic defects and heterostructure compositions [Obj.II], as well as lattice fluctuations [Obj.III], on the mechanisms dominating exciton relaxation and diffusion and their resulting mobility and lifetime. Our research will thus allow for a comprehensive and predictive understanding of the underlying physics dominating exciton decay processes in materials of emerging interest via front-line computations, offering novel and tunable design principles for optimized functionality.

Keywords: exciton dynamics,many body perturbation theory,gw bse,two dimensional semiconductors,organic semiconductors,excited state phenomena,bandstructure methods
Alliance for Modelling Industries towards the Green Deal’s objectives And circuLArity (AMIGDALA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Netherlands,Germany,Belgium,Austria,Italy,France,Spain,Estonia
Call: Modelling industry transition to climate neutrality, sustainability and circularity (Processes4Planet partnership) (RIA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 8164300.19
EU funding (EUR): 7309327.2
Participants: 13
Project status: SIGNED

The objective of the European Green Deal policy is to be climate-neutral by 2050. However, the key problem of the industry transition towards climate neutrality is that the combined response of demand, global trade and industrial production to policy measures is highly complex. The aim of the AMIGDALA project is to facilitate decision makers in governments and in the EU’s industries to define and evaluate pathways towards climate neutrality, circularity and sustainability. In this project we combine insights in decision-making with integrated modelling of scenarios to analyze transformation pathways. We analyze decisions-making in government and in industry by the control options that they have such as incentives, regulatory measures and investments in capital projects to contribute to the Green Deal’s objectives. We deliver an integrated model to represent EU industry’s transformation pathways up to 2070 and cover historical developments from 1990. We develop a method to combine established models of separate domains and let them operate as-one. This integrated model shows the combined effect of control options on economy, trade, energy, materials flow, biomass and industrial production on an EU systems-level and within a global context. On a local-level we use models to analyze the decisions by industry clusters to invest in transformative solutions and utility operators to build infrastructure. With the integrated model we run scenarios that we develop on the basis of the control options of decisionmakers to achieve industrial transformation towards climate neutrality. The integrated model allows to analyze the effect of framework conditions on the uptake of transformative solutions and products and on energy demand, emissions, and material use. The AMIGDALA consortium has a deep and shared knowledge of technologies, economy, life cycle analysis and complex systems modelling and decision support analysis.

Keywords: industry transformation modelling scenario pathway decision government industry policy investment circularity economy demand trade production feedstock biomass waste greendeal sector analysis system