Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Labeling Flavivirus capsid protein to unravel its dynamics during infection and egress by correlative super-resolution fluorescence and cryo-electron microscopy (FLAVIC DYNAMICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Vector-borne diseases are major worldwide threats. Specifically, mosquito-borne diseases from the flavivirus genus such as West Nile and dengue viruses are raising major concerns on human health. There are few or no treatment/vaccine strategies to fight these viruses and the relatively poor knowledge of their life cycle (entry and egress) contributes to the deficit in treatment possibilities. A deeper knowledge of the virus cycle is required to unlock the development of antivirals. Understanding the dynamics of the viral proteins and their interactions in vivo strongly relies on quantitative and high resolution imaging methods. These methodologies in turn require specific protein-labeling strategies, which are presently quite limited for flavivirus. Significant advances in understanding flavivirus biology can be expected if such labeling tools were available. The major goal of this project is to understand the delivery of the flavivirus genome to its translation site at the cytoplasmic side of the ER membrane; the cellular components and machineries that intervene and the role and paths of the Capsid protein during this process. Super-resolution PALM/STORM techniques will be used and superposed to cryo-EM data and the yellow fever virus attenuated 17D strain will be used as model flavivirus for the main project milestones. We will devise and optimize new labeling strategies for capsid protein and use them to track the virus in vivo and follow the path of the capsid protein after release from the virus during cell entry. The project, thus aims to provide a labeling tool that will boost flavivirus research and to advance our knowledge of flaviviruses’ life cycle.

Keywords: flavivirus,capsid protein,protein labeling,super resolution microscopy,single particle palm,cryo em,correlative microscopy,cytoskeleton,viral infection,viral dis assembly
3D integration of a logic/memory CUBE for In-Memory-Computing (MY-CUBE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 2734139.0
EU funding (EUR): 2734139.0
Participants: 1
Project status: SIGNED

For integrated circuits to be able to leverage the future “data deluge” coming from the cloud and cyber-physical systems, the historical scaling of Complementary-Metal-Oxide-Semiconductor (CMOS) devices is no longer the corner stone. At system-level, computing performance is now strongly power-limited and the main part of this power budget is consumed by data transfers between logic and memory circuit blocks in widespread Von-Neumann design architectures. An emerging computing paradigm solution overcoming this “memory wall” consists in processing the information in-situ, owing to In-Memory-Computing (IMC). However, today’s existing memory technologies are ineffective to In-Memory compute billions of data items, as it is the case in the brain. Things may change with the emergence of three key enabling technologies: non-volatile resistive memory, new energy-efficient nanowire transistors and 3D-monolithic. My-CUBE will leverage them towards a functionality-enhanced system with a tight entangling of logic and memory. Only such a technology can support the scalability of the IMC concept. Following a holistic approach from the system to the material, My-CUBE unique solution relies on a new class of nano-technology, mixing at the fine-grain level a high capacity of non-volatile resistive memory coupled with new junctionless nanowire transistors 3D-interconnected at low-temperature, to perform data-centric computations. A 3D IMC accelerator circuit will be designed, manufactured and measured, targeting a 20x reduction in (Energy x Delay) Product vs. Von-Neumann systems. This technology that adds smartness to memory/storage will not only be a game changer for artificial intelligence, machine learning, data analytics or any data-abundant computing systems but it will also be, more broadly, a key computational kernel for next low-power, energy-efficient European integrated circuits.

Keywords: nano technology,cmos,transistor,memory,computing system,circuit design
Selective Pathways for Carbon-Nitrogen Bond Cleavage (SCAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Amines are ubiquitous across natural products, pharmaceuticals, polymers and biomolecules. The number of commercially available amines, from simple to complex, makes them one of the most accessible native functional groups. Therefore, they represent an attractive feedstock for the preparation of functionalized molecules through C-N bond activation. Nature long ago developed protocols to promote oxidative deamination reactions. Inspired by this approach, SCAN (Selective Pathways for CArbon-Nitrogen Bond Cleavage) is designed to open new directions in the field of C-N bond cleavage by unlocking the oxidative deamination pathway. To achieve this goal, the following specific objectives are proposed: 1) Design of redox-active amines capable of undergoing oxidative C-N cleavage. 2) Development of novel oxidative deaminations using photoredox and metallaphotoredox catalysis. 3) Site-selective modifications of peptides through photocatalyzed oxidative deaminations. The successful implementation will allow the use of one of the most readily available functional groups in a myriad of novel catalytic transformations, including for the first time asymmetric catalysis. The prevalence of alkyl amines in pharmaceuticals makes SCAN an ideal tool for late stage functionalization and molecular editing of complex molecules. Moreover, this reactivity could be used to achieve site-selective modifications of NH2 groups in peptides via C-N bond cleavage, which would have a profound impact in the fields of chemistry and chemical biology. Together, the conceptual novelty, the ability to pursue multiple complementary approaches at once, and the various potential applications will ensure high impact of this project in both the academic and industrial communities.

Keywords: amines,c n activation,transition metal catalysis,asymmetric catalysis,photocatalysis,radical chemistry,drug discovery,peptides
Valorisation of MOF-based VOC Gas Sensors (MOVOS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Belgium
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-04-01
End date: 2022-03-31
Duration (months): 12.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Considerable progress has been made in the FET Open SPRINT project. Technology has been developed for the vapour phase deposition of metal-organic framework thin films in mild conditions. Metal-organic frameworks are crystalline nanoporous materials of which the pore properties can be tuned. Derivative applications of this technology are being explored such as gas sensors and low-k insulator films for microelectronics. Proof-of-concept gas sensors based on MOF thin films have been built and evaluated. MOVOS focuses on gas sensors and aims to build market and technical knowledge by close interaction with the value chain. In addition a portable demonstrator will be developed that builds further on the lab sensor concepts.

Keywords: nanotechnology,nanoporous materials,ultrathin films,gas sensors,metal organic frameworks
Unveiling complexity in Functional hybrid OXides (UFOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-25
End date: 2017-05-24
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

The purpose of this research project is to get a deeper understanding of the mechanisms and the fundamental interactions that control the formation of electronic ordered phases and the competition between different phenomena in 4d and 3d-4d hybrid transition metal oxides (TMO). Investigation of 4d materials, proposed here, provides new challenges and opportunities – they share some common features with 3d systems which stem from electron correlations, but have in addition subtle sensitivity of the electronic states to the lattice structure, effective dimensionality and, most importantly, to relativistic effects due to stronger spin-orbit coupling. The aim of the project is to exploit the class of 4d perovskite ruthenium oxides together with different 4d-3d families of doped materials as a platform for exploring in a controlled way the interplay between correlations, dimensionality and spin-orbit effects when moving from 4d to 3d oxides. Doping a 4d host with 3d impurities might be extremely effective in tuning valence, spin and orbital characteristics and, in turn, the macroscopic physical properties of bulk and layered systems. An ultimate goal is to exploit the variety of physical phenomena inherited in these classes of materials to design interfaces and heterostructures which can show properties at the nanometer scale that are qualitatively different from their single building blocks, thus allowing to engineer novel functionalities. Such a rich scenario can open the route to the fabrication and design of systems where novel and multiple functionalities are nano-integrated on the same “chip”. The key challenge of the present project is, then, both to unveil the complexities due to the interplay between the “dimensionality” and the “spin-orbital-charge-lattice” degrees of freedom and to disentangle them to get insight into the nature of the ordered states and the physical phenomena in 4d-3d systems, as well as in 4d-3d oxide interfaces and heterostructures.

Keywords: transition metal oxides,magnetism,correlated electron systems,electronic structure,oxides heterostructures,interface physics
On the development of novel molecular and microscopy methodologies for the interrogation of host-pathogen interactions at the single-cell level (FISHnCRISPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 173464.32
EU funding (EUR): 173464.32
Participants: 1
Project status: CLOSED

Over the course of host-pathogen evolution, both the players in this game have set out strategies to overcome each other, by adapting to challenging environments and camouflaging on the one side, and by detecting and eradicating the enemy on the other. In this context, the identification of the pathogenic potential, that is, the genetic elements conferring virulence and how they subvert the host’s defences, is fundamental. With a multiplexed approach, I aim at developing a pooled genetic screen using CRISPR interference to produce pathogen knocked-down libraries impaired in a curated subset of virulence factors of Salmonella Typhi. This pathogen is of particular interest because of the severity of its systemic infection combined with its human host-restriction, which left research lagging behind. Several cellular systems (macrophages, PBMCs, organoids) will be probed upon infection of S. typhi mutants, and the host transcriptome retrieved by single-cell RNA-seq. This analysis will provide a systematic and thorough map of the cause and effect network of the pathogen virulence factors and host responses. Interestingly, in this pathogen-host “war”, each battle can end with a different winner, even when the teams are comprised of the same players, meaning that the heterogeneity in the cellular state of both the pathogen and the host previous to the infection, can lead to the occurrence of diverse outcomes within a single population. The pathogen can either replicate, persist or be cleared by the host. This intrinsic cell-to-cell variability posits the importance of profiling simultaneously the host and the pathogen at the level of single cells. To achieve this goal, I will profile the transcriptomes of the host and the pathogen at the same time, by using multiplexed smFISH. This analysis will quantitatively untangle the contribution of heterogeneity to disease outcomes.

Keywords: host pathogen interactions,smfish,multiplexed imaging,pooled genetic screens,crispri,scrna seq,salmonella
Energy Efficient FPGA Accelerators for Graph Analytics Applications (FPGA Accelerators)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 145845.6
EU funding (EUR): 145845.6
Participants: 1
Project status: CLOSED

It is reported that data centers today consume up to 3 percent of the global electricity usage. This is expected to increase in the upcoming years as the amount of data processed in the cloud increases substantially. An effective way for data centers to achieve better performance and energy efficiency is to perform computation on specialized processing elements. Field programmable gate arrays (FPGAs) enable customization of logic after manufacturing to achieve better energy efficiency compared to general purpose processors. Today, prominent hardware and software companies are investing in data center solutions that integrate FPGAs with CPUs, and significant energy consumption and performance improvements have been demonstrated for several data center applications. However, the main barrier for wide spread adoption of FGPAs in data centers is the cost of programming, which typically requires months of development time by hardware designers. This makes it unaffordable for small-to-medium software companies to effectively utilize the available FPGAs. The purpose of this project is to lower this barrier for emerging graph analytics applications for knowledge discovery and machine learning. The basic idea is to use an abstract interface that allows a domain expert to describe an application as a set of serial functions defined per vertex and/or edge. We propose a customizable implementation template that automatically maps the abstract user functions to massively parallel FPGA implementations. The proposed template will hide from users many low level implementation details such as parallelization, pipelining, synchronization, memory access optimization, race and deadlock avoidance, etc. This will help bridge the gap between high level application descriptions and costly hardware implementations. Our preliminary architecture simulations have shown that the proposed graph processors can achieve significantly better energy efficiency than general purpose processors.

Keywords: heterogeneous architectures,field programmable gate arrays,hardware accelerators,graph analytics,energy efficient computing,high performance computing
The role of Von Willebrand Domain-containing Protein 8 in mitochondrial physiology (Mitobetes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Mitobetes project brings a new research on poorly characterized mitochondrial protein involved in important cellular and physiological processes such diabetes, kidney failure and cancer. It also aims on the role of mitochondria in diabetes, the disease which affects almost 10% of European population. The mitobetes project has a potential to help to find a new mitochondrial protein involved in diabetes, find a mechanism of diabetes development, increase the public knowledge about diabetes and thus helps to decrease EU healthcare costs. Mitochondria are crucial organelles not only in energy conversion, but also in a plethora of other biological processes. Their function is closely related to their dynamics, controlled by the pro-fusion proteins Mitofusin (Mfn) 1 and 2 and Optic atrophy 1 (Opa1); and by the fission proteins mitochondrial fission factor (Mff) and dynamin related protein 1 (Drp1). Opa1 not only controls mitochondrial fusion, but also shape of the mitochondrial cristae, a crucial parameter in determining mitochondrial function and participation in apoptosis. Opa1 exists in high molecular weight complexes of unknown composition that are dynamically modulated during cristae remodeling. Recently, the host laboratory completed a proteomic catalogue of proteins associating with Opa1 in intact cristae and leaving the complex only when cristae shape was disrupted. Among the hits associating with Opa1, the host lab discovered Von Willebrand Domain-containing Protein 8 (Vwa8), a mitochondrial protein of unknown function whose higher levels correlate with worse prognosis of Acute Myeloid Leukemia (AML). Here, I propose to understand the function of Vwa8 in mitochondrial network and cristae shape, Opa1 function, apoptosis and bioenergetics. This project will not only characterize the role of a novel protein in involved mitochondrial morphology and function, but also verify if a link between mitochondrial morphology and AML exists.

Keywords: mitochondrial fission and fusion,diabetes,acute myeloid leukemia,vwa8,opa1,cristae
Sub-Terahertz Analog-to-Digital Conversion Using Integrated Soliton Microcombs (CompADC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Modern information and communication technology has been propelling the rapid expansion of signal spectrum bandwidth towards the level of hundreds of GHz and even 1 Terahertz. Such wideband analog signals produced in physical world must be converted to a stream of data bits via analog-to-digital conversion (ADC), for ultra-fast and flexible digital signal processing (DSP). However, the random electron fluctuations in semiconductors set a fundamental limitation on the performance of electronic (ADCs), leading to an inherent trade-off between the sampling accuracy and bandwidth. State-of-the-art electronic ADCs typically have only GHz-level analog bandwidth, which is becoming an increasingly severe limitation on high-speed DSP applications. Although the adoption of mode-locked lasers (MLLs) can overcome some limitations using the ultra-stable pulse train for precise time-domain sampling, the GHz-level repetition rate and the challenging integration of MLLs prevents any usability of photonics-assisted ADC in practical applications. In the CompADC project, I propose to develop a radically-new photonic ADC scheme using chip-scale dual optical frequency combs, enabling real-time digitization of ultra-wideband RF and microwave signals with a bandwidth of > 100 GHz. This envisaged performance is enabled by the emerging dissipative Kerr soliton (DKS) microcombs generated in SiN microresonators, which produces a new type of on-chip mode-locked emission of optical pulses with repetition rates exceeding 100 GH. These phase-locked dual microcombs (signal comb and local oscillator comb) will perform precise frequency-domain decomposition and parallel frequency down-conversion of ultra-wideband microwave signals to the detectable range of lower-speed electronics. This CompADC approach has the clear potential to offer unparalleled performance and chip-scale integration for modern ultra-wideband signal processing and communication applications.

Keywords: microwave photonics,integrated photonics,ultrafast signal processing,photonic analog to digital conversion
European Live Translator (ELITR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Czechia,United Kingdom
Call: A multilingual Next Generation Internet (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-03-31
Duration (months): 39.0
Total project cost (EUR): 2959112.5
EU funding (EUR): 2916362.5
Participants: 6
Project status: CLOSED

The goal of the ELITR project is to remove the language barrier in communication within and among European citizens, companies, institutes and organizations at large assemblies like conferences, in smaller live discussions like workshops and in discussions held over long distance like formal or informal online meetings. Within the project, we will create automatic subtitling system of live meetings and conference presentations and provide the system of spoken language translation (interpreting). Furthermore, the project will design and implement automatic minuting, i.e. create structured summaries from automatic transcript of a discussion. We also aim to advance the state of the art to deliver machine translation of high-quality at the level of whole documents and to scale up to multilingual settings with dozens of source and/or target languages. The technologies will be tested by the Supreme Audit Office of the Czech Republic and alfaview®, a German online conferencing system.

Keywords: spoken language translation,automatic speech recognition