Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Addressing Antibiotic Resistance: New Strategies for Overcoming the ESKAPE Pathogens (NO-ESKAPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands,Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1784041.25
Participants: 2
Project status: SIGNED

Antibiotic resistance poses an alarming threat to global health. Most worrisome are the so-called “ESKAPE” pathogens (E. faecium, S. aureus, K. pneumoniae, A. baumanii, P. aeruginosa, and Enterobacter species), a collection of organisms capable of escaping the effects of almost all conventional antibiotics. Key to combating drug-resistant bacteria is the identification of new antibacterial targets and the ability to exploit these targets with novel and unconventional antibiotics. The microbial world produces a wealth of antibacterial compounds that, while not suitable for therapeutic use, operate by diverse and unique modes of action. This proposal describes innovative approaches aimed at the discovery and development of such compounds as leads towards novel antibiotics with entirely new modes of action. Using a multidisciplinary approach, firmly grounded in synthetic organic chemistry, I will prepare and validate new antibiotics that target the ESKAPE pathogens by exploiting mechanisms critical to their survival and/or resistance. To tackle the Gram-positive ESKAPE pathogens a number of new approaches to interfering with bacterial cell wall biosynthesis will be examined. Specifically, novel (semi)synthetic compounds capable of binding to and sequestering various bacterial cell wall precursors will be prepared and their antibiotic activity assessed. To address the Gram-negative ESKAPE pathogens, inhibitors of the metallo-beta-lactamase enzymes responsible for much of their antibiotic resistance will be pursued. These inhibitors will be achieved via a combination of rational design strategies and innovative natural product screening approaches. The 21st century threat of a post-antibiotic era makes clear the need for innovation in antibacterial drug discovery. The strategies outlined in this proposal address this threat head-on with the aim of delivering valuable lead compounds in pursuit of novel antibiotics.

Keywords: antibiotics,semi synthesis,peptides,natural products,bacterial cell wall,metallo beta lactamase inhibitors,mechanism of action,antibacterial assays,resistance assays,enzyme assays
Quantum Algebraic Structures In Field Theories (QUASIFT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 1
Project status: CLOSED

Quantum Field Theory is a universal framework to address quantum physical systems with infinitely many interacting degrees of freedom, applicable both at the level of fundamental interactions, such as the subnuclear physics of quarks and gluons and at the phenomenological level such as the physics of quantum fluids and superconductivity. Traditionally, weakly interacting quantum field theory is formulated as a perturbative deformation of the linear theory of freely propagating quantum waves or particles with interactions described by Feynman diagrams. For strongly non-linear quantum field theories the method of Feynman diagrams is not adequate. The main goal of this proposal is to develop novel tools and techniques to address strongly non-linear quantum field theories. To achieve this goal we will search for hidden algebraic structures in quantum field theories that will lead to efficient algorithms to compute physical observables of interest. In particular we identify non-linear quantum field theories with exactly solvable sectors of physical observables. In this project we will focus on three objectives: - build general theory of localization in supersymmetric Yang-Mills theory for arbitrary geometrical backgrounds - find all realizations of symplectic and supersymplectic completely integrable systems in gauge theories - construct finite supersymmetric Yang-Mills theory in terms of the algebra of locally supersymmetric loop observables for maximally supersymmetric gauge theory The realization of the above objectives will uncover hidden quantum algebraic structures and consequently will bring ground-breaking results in our knowledge of quantum field theories and the fundamental interactions.

Keywords: quantum field theory,string theory,supersymmetry,integrable systems,yang mills theory,gauge theory,non perturbative,instantons,topological fields,quantization,poisson,mirror symmetry
The Consequences of the Internet for Russia's Informational Influence Abroad (RUSINFORM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-11-01
End date: 2025-10-31
Duration (months): 72.0
Total project cost (EUR): 1999535.0
EU funding (EUR): 1999535.0
Participants: 1
Project status: SIGNED

Over the past decade, Russia’s ruling elites have massively stepped up their efforts to influ-ence media audiences abroad. Amongst others, Russia has been alleged to have sought to sway votes in Austria, France, Germany, Ukraine, and the US. This project’s overarching research ques-tion is: How, and with what consequences, have new Internet-based technologies contributed to the emergence of novel resources, techniques, and processes by which political elites in Moscow can influence media audiences abroad? In order to address this question, a theoretical work package (WP4) will undertake the first major systematic effort to interrogate how much, or how little, we can leverage extant in-depth knowledge of former-Soviet foreign propaganda, conducted in the broadcast era, in order to make sense of Russia’s recent digitally-enabled efforts. WP4 will be informed by three empirical WPs. They will scrutinize three heavily digitally-enabled elements of Russia’s recent efforts: • WP1 will conduct a comprehensive in-depth study of foreign active online audiences and other co-creators of Russia-related content. • WP2 will produce pioneering research about how social media platforms function as key transmission channels that connect Russia’s domestic media with Russian-speaking audiences abroad. • WP3 will be the first study to scrutinize the role of the Kremlin-controlled search engine Yan-dex as a resource of foreign influence. Methodologically, WP1-3 are highly innovative because they combine new computational methods (data mining, automated text analysis) with traditional methods (surveys, in-depth inter-views, grounded theory). In response to Russia’s recent efforts, countermeasures have been ushered in by a plurality of actors, including the EU, NATO, and NGOs. These actors will benefit immensely from the knowledge generated, which will enable them to enhance their initiatives to secure democratic elec-toral processes against undue informational interference.

Keywords: political communication,international,foreign communication,comment sections,participatory journalism,counterpublic theory,russian area studies,computational methods,qualitative methods
Industrial scale PET chemical recycling via an innovative glycolysis process (ChemPET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2023-09-30
Duration (months): 49.0
Total project cost (EUR): 2557500.0
EU funding (EUR): 1790250.0
Participants: 2
Project status: SIGNED

The massive industrial use of Polyethylene Terephthalate (PET) poses serious economic and environmental problems due to its poor recyclability. Current PET disposal options include incineration, landfilling and recycling while a relevant amount is still dumped into oceans. Landfilling and incineration are however outdated since environmentally unsustainable. Recycling is the preferred option, but a series of technological barriers limit the recycling into high-quality rPET (recycled PET). The ChemPET project aims to scale-up a cutting-edge chemical recycling technology, based on glycolysis, for PET based waste converting it into monomer BHET. Currently, there are no alternatives which guarantee efficient results at industrial scale considering heterogeneous PET feedstock. BHET can be newly used as raw material in the production of virgin PET instead of the terephthalic acid (TPA) and the ethylene glycol (EG) that derive from crude oil. This determines advantages for the PET value chain in terms of environmental sustainability, competitiveness and job creation. ChemPET will help Europe to achieve the “Zero Plastics to landfill by 2025”, promoting the Circular Economy and reducing Europe dependency on fossil feedstocks. ChemPET project foresees the technical improvement of ChemPET technology and the valorisation of by-products. After the optimization of the BHET production phase, GARBO will collaborate with many stakeholders across plastic industry value chain to maximize the business opportunities and foster the uptake of ChemPET technology. The production of chemical recycled PET (crPET) from BHET will close the loop supporting the growth of the circular economy thus reshaping the PET value chain at whole. Large occupational benefits are expected by the replication of ChemPET process.

Keywords: circular economy,recycling,depolimerisation,waste,recovery,plastic,packaging,sustainability,industrial chemistry,crpet
Innovation in the road freight transportation chain facilitating sustainability and low cost: A socio-technical perspective on work and development of road freight transport markets. (InnoMarket)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

InnoMarket is opening the black box of the international road freight transport market, which is organized as a bazaar. The project will investigate this 'institutional order' of road freight transportation that leads to unintended inefficiencies such as less than full truck loads. The objective is firstly to identify innovative potentials for lowering cost and increasing sustainability by analyzing practices of overlapping markets and built-in controversies in the transport chains. Secondly, the project aims at closing a gap in transport research by explaining the low implementation rate of (existing) innovations. Theoretically, the project builds on market making literature and the socio-technical view of innovation processes. An ethnographic action net study is applied to investigate the overlapping markets and international inter-sectoral transport chain actors; the industrial shipper, customer, intermediaries, transporter and drivers. The study involves 50 interviews in Poland, Denmark and Sweden and “shadowing” actors. The results of the study is a novel perspective on how road transport markets work, contributing to knowledge of transport-chain efficiency, sustainability and innovation that is needed in EU as well as in other parts of the world. CBS research expertise in transportation, constructivist market theory and ethnography advances the fellow in research, methodology and publication. CBS Business-in-Society activities advance the fellow in dissemination; public podcasts; practitioner workshops, and publications. Host professor supervises in transport and logistics research, in workshop method, publication and editorship skill. Secondment at ITD/International Transport Denmark´s innovation center offers training-in-innovation projects. Fellow research profile is broadened, including organizing, transportation expertise, ethnographic action net methods, publishing, outreach experience, and an international network of academics and non-academics.

Keywords: organizing,action net,road freight transportation network,market making,innovation,low costs,sustainability,ethnographic methods
From Cloud to Star Formation (CSF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-11-30
Duration (months): 63.0
Total project cost (EUR): 1616050.0
EU funding (EUR): 1616050.0
Participants: 1
Project status: CLOSED

Star Formation is a hierarchical process from the build-up of large clouds to the assembly of stars. This ERC project aims at studying the multi-scale processes of this conversion from diffuse gas to stars. The fundamental data are provided by two PI-led large observing programs at two of the most advanced radio and mm interferometers, the Very Large Array (VLA) and the Plateau de Bure Interferometer (PdBI). This combined approach is designed to address outstanding key questions in the field of cloud and star formation. The 225 hours THOR program at the VLA investigates the cloud formation and conversion of atomic to molecular gas, as well as feedback processes back to the interstellar medium (ISM). To reach these goals, THOR observes the Milky Way in atomic HI, molecular OH, and cm continuum and radio recombination lines tracing the ionized components of the ISM. At smaller spatial scales, the 300 hours PdBI project CORE will study the fragmentation of the gas clumps to form clusters, the formation of accretion disks and outflows, and the gas infall rates as proxy for the accretion rates. Therefore, assisted by Atacama Large Millimeter Array (ALMA) observations, we will investigate a sample of high-mass star-forming regions at the highest spatial resolution of 0.2'' to dissect the physical processes during the assembly of the highest mass stars. The core aim of this ERC project is to study all spatial scales from molecular clouds to individual massive cores. This will be a decisive step in the understanding of the conversion of gas and dust into stars. Through his decade-long expertise and leadership in star/cloud formation, the PI is uniquely positioned to advance the field significantly. The surveys at the heart of the program are extremely computing and work intensive accumulating data in the 100 TByte regime. This proposals asks for a strong core group of three postdocs and one PhD student to conduct the project and fully exploit the scientific results.
Airlander Civil Exploitation Project (ACEP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2017-07-31
Duration (months): 25.0
Total project cost (EUR): 4005477.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The Airlander hybrid air vehicle is a new form of aircraft designed by Hybrid Air Vehicles Ltd (HAV). The vehicle combines inert lifting gas, aerodynamics and vectored thrust to deliver ‘game changing’ performance, compared to current flight technologies. Performance advantages include 1/3rd the fuel burn of conventional aircraft, reduced reliance on infrastructure and intermodal transport due to the unique amphibious all-terrain landing gear technology. The technology is therefore aligned with the ‘Smart, Green and Integrated Transport’ work programme. The full scale prototype (TRL 6/7) reached first flight in 2012 under a US Army programme. Following first flight the programme ceased due to US budget constraints. HAV purchased the vehicle, disassembled and returned it to the UK and had the International Traffic in Arms Regulations restrictions removed. HAV’s business strategy is to build an order-book for a civil variant of this technology by progressively reducing the risks for customers. However, the Company needs to develop a regulatory framework for certification of this vehicle type with the European Aviation Safety Agency (EASA) and migrate the technology from the military specification and certification it was originally designed under to the agreed EASA civil standard. The Airlander Civil Exploitation Project (ACEP) will undertake this work, resulting in a fully specified civil variant, an engaged regulator, approved regulations and significant risk reduction for commercial customers, thereby allowing orders to be made. The market for this technology has been verified as over $50 billion. The business opportunity is to capitalise, via the European civil marketspace, on the $150m of US DOD military investment in this revolutionary aircraft type, and bring this new low carbon vehicle, with global application, to a position where it can enter production in Europe. This would see HAV realise its goal to become the global leader in hybrid air vehicles.

Keywords: migration of new low carbon flight technology,developed under us military contract,to the civil variant and regulatory standard,body
Macroeconomic Dynamics with Product Market Frictions (MACROPMF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Italy
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 1192000.0
EU funding (EUR): 1192000.0
Participants: 1
Project status: CLOSED

The transmission of microeconomic and macroeconomic shocks to firms' price and demand in product markets is the cornerstone of a large volume of macroeconomic literature. Product market frictions, by reducing the ability of demand to relocate across different suppliers, affect firms' incentives when setting prices, and therefore the pass-through of shocks to both demand and prices. In this project we plan to study the implications of product market frictions for firm level price and demand dynamics, as well as for macroeconomic dynamics. The aim is to integrate micro and macro economics, both theoretically and empirically, to a greater extent than is currently done in the literature. We will apply our tools to two main areas of interest. First, we will study how product market frictions affect the optimal pricing decision of firms, and the relocation of consumers across different suppliers. We will provide novel empirical microeconomic evidence on the relationship between price and consumer dynamics. We will build a rich but yet tractable model where product market frictions give rise to firm pricing with customer markets. The aim is to use observable statistics from the micro data to estimate the key parameters of the model and quantify the relevance of the product market frictions for firm pricing and demand dynamics. Second, we will explore the importance of product market frictions for macroeconomic dynamics. We will apply our quantified model of price and consumer dynamics to areas of macroeconomics where we expect our methodology and empirical analysis to be more relevant, both because of the types of questions addressed and because of a direct relationship with the mechanism. In particular we will focus on the role of product market frictions for business cycle fluctuations and international trade.

Keywords: product market frictions,price setting,business cycles
Actiwhey based microencapsulation solution for sustainable food manufacturing (ACTICAPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Finland
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2015, 2015)
Start date: 2015-10-01
End date: 2018-03-31
Duration (months): 30.0
Total project cost (EUR): 1478618.75
EU funding (EUR): 1035033.0
Participants: 1
Project status: CLOSED

Overuse of antibiotics in meat production causes human antimicrobial resistance, diseases and gut related disorders, leading to 1.2m life-threatening hospital infections and 19,000 deaths from MRSA-bacteria each year. The best solution is sustainable antibiotic free food production, improved food safety and nutrition value, wider use of probiotics and increased functional foods production. Companies like Bon Appétit, Tyson Foods, Smithfield, McDonalds, etc. are voluntarily banning antibiotics treated food products. To meet this trend and EU regulations, new cost-effective technologies for processing delicate substances and active ingredients are needed in EU. Uniq Bioresearch has developed and patented ACTIWHEY® microencapsulation technology that addresses these challenges and provides market leading nutritional efficiency; extended shelf-life, increased food safety and countless new opportunities for food, feed and nutraceuticals manufacturers. ACTICAPS project aims to 1) reduce the microencapsulation costs by 91%; 2) achieve 70% fill-coating ratio; 3) improve controlled release and other key advantages; 4) set up pilot production for market validation and dissemination; 5) create a scale-up package, incl. process planning strategy, production manuals and licencing concept; 6) validate the innovation in 3 market segments with most potential for fast market uptake. This project is an integral part of our long-term development roadmap. Our market uptake potential is based on 11+ years of R&D and business success; established key customer base; validated patented technology, experienced team and detailed feasibility study for identifying the best business and commercialisation strategy. We target a high growth €7.3b market and expect to generate sales revenue of €38m and create more than 50 new jobs by 2022. Besides current customer base, we have received potential order indications from market-leading feed and food producers like Hankkija, Raisio, Valio etc.

Keywords: microencapsulation,whey,functional foods,nutraceuticals,food packaging,sustainable food,production,coating