Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable and affordable URban Geothermal Exploration Novel Technologies and workflows (URGENT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Belgium,Netherlands,Poland,Hungary,France
Call: Advanced exploration technologies for geothermal resources in a wide range of geological settings (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-06-01
End date: 2027-11-30
Duration (months): 42.0
Total project cost (EUR): 3998757.5
EU funding (EUR): 3998757.5
Participants: 8
Project status: SIGNED

Europe needs URGENT solutions to decarbonize its heating sector. Geothermal energy can play a prominent role in this transition, providing heat in urban areas as an alternative to fossil fuels. However, its growth is hampered by the limited knowledge about the resources and risks in these challenging environments. Existing exploration methods are not suited for reservoir characterization in urban contexts. The URGENT project addresses this gap by providing sustainable and affordable solutions for urban seismic exploration of geothermal resources. Low-impact innovative technologies, consisting of an electric seismic source and novel MEMS based sensors integrated into autonomous nodes, will be designed, built, and tested on 3 sites: Balmatt (BE), Konin (PL), Batta (HU). They will enable high-quality data recording including low frequency signals resulting in high resolution imaging up to 4000m of depth. Ultimately, improved reservoir characterization will reduce the geological uncertainties and contribute to increase drilling success rate by 20%. Also, by optimizing survey design, including compressive sensing and simultaneous shooting, URGENT eventually aims at reducing exploration costs by 30%. For more efficient analysis of the acquired data, AI & ML methods will be developed and tested to assist and automate fault and fracture detection. Structural models including these features will be the basis for geomechanical modelling to assess fault reactivation and the corresponding seismic risk. In addition, ML techniques used in the O&G sector will be updated and combined with THM reservoir modelling to optimize the location and design of wells, maximizing heat extraction while minimizing seismic risk leading to increase plant lifetime up to 40 years and higher revenue. URGENT will contribute to accelerate the deployment of urban geothermal projects through exploration workflows suited for these environments, market uptake analysis and reinforced community acceptance.

Keywords: urban geothermal exploration,aiand ml driven fault detection,well placement optimization,electric seismic source,mems seismic receivers,integrated exploration strategies,seismic risk reduction
Towards modulator therapy for ADA2 deficiency (MODULATEDADA2)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-11-01
End date: 2026-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Human ADA2 deficiency is a rare inborn error of immunity caused by pathogenic variants in ADA2. The disease has a wide array of presentations ranging from vasculitis of the skin to the central nervous system (with strokes), fevers and immunodeficiency to cytopenia and bone marrow failure. Mortality is 10%, and occurs mostly in childhood. TNF inhibitor treatment is efficient for treating the vasculitis, but the bone marrow failure is refractory to treatment and requires hematopoietic stem cell transplantation (HSCT). In the context of DADA2, HSCT is complicated by graft failure in a high percentage of patients. Therefore, the treatment of cytopenia in DADA2 represents an urgent medical need. This project is built on the discovery, made during the course of the ERC St Grant MORE2DADA2, that it is possible to restore ADA2 expression in missense mutant cells by drug intervention in vitro, providing a first layer of evidence for the possibility to use modulator therapy in ADA2 deficiency. Therefore in this project, we wish to identify additional modulators for ADA2. Our goal is to identify drugs that are able to restore in part or completely the ADA2 expression and function as well as the transcriptomic and metabolomic signature of ADA2 mutant cells. The ultimate goal is to take these modulators to the DADA2 patients.

Keywords: dada2 modulator therapy
T cell subsets underlying the rise, fall and recall of the Germinal Center (GC T Subsets)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2129247.0
EU funding (EUR): 2129247.0
Participants: 1
Project status: SIGNED

Follicular helper T cells (Tfh), through their cognate interactions with B cells, drive the Germinal Center (GC) reaction resulting in affinity matured memory B cells and Plasma cells, hallmarks of the adaptive immunity and underpinning our ability to counter pathogenic insults. For mounting a successful response against most pathogens, including the virus SarS-CoV-2 that has crippled most nations for over a year, Tfh cells are of central importance. Aberrant activation of Tfh has also been implicated in many diseases, including Multiple Sclerosis, Diabetes and Lymphoma. Understanding Tfh biology is essential for our understanding of the adaptive immune system and in our quest to develop better vaccines and therapeutic treatments, as it will enable us to modulate GC output. Through work over multiple years, the applicant has developed an understanding for Tfh as a highly dynamic population that require equally dynamic regulation. Understanding the true nature of Tfh, and of the T cell subsets that regulate Tfh, including the molecular mechanisms of regulation, will necessitate the combination of new tools with already existing state-of-the-art methods that is proposed herein. This will lead to a new understanding of how Tfh drive B cells throughout the GC, how they shape B cell responses, shedding light on unresolved issues such as how different quality of memory B cells is formed, and how the unappreciated phenomenon of GC termination, proceeds. Specifically this proposal will result in 1) A new definition of Tfh and of GC T cell regulatory subsets. 2) A mechanism for Foxp3+ T cell mediated regulation of GC B Cells and GC termination and 3) A new understanding of the origin and quality of Tfh memory and associated GC T cell memory.

Keywords: tfh,germinal center,regulatory t cells,mechanism,tfh memory
Fabrication of Wide Bandgap Chalcopyrite Photovoltaics at Low Temperatures for Prospective Tandem Solar Cells (FaWB ChaLT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-12-31
Duration (months): 30.0
Total project cost (EUR): 225317.2
EU funding (EUR): 225317.2
Participants: 2
Project status: CLOSED

Adapting photovoltaics as a reliable renewable energy source, advanced technological solutions must be brought at the cell level. The power conversion efficiency targets must be higher than the currently available commercial single-junction solar cells of silicon (Si) or low-bandgap copper indium gallium selenide (CIGSe). The efficiency of photovoltaics can be increased by joining two cells in a single stack (top/bottom) called a tandem solar cell. Such a configuration needs a wide bandgap solar cell to be joined atop the commercial low bandgap Si or CIGSe photovoltaics. This project aims to develop such a wide-bandgap thin-film solar cell. By careful compositional engineering, silver (Ag) will be substituted for a fraction of copper (Cu) in sulfur-rich CIGS to yield wide bandgap (1.65-1.7 eV) ACIGS absorbers. Ag substitution is expected to reduce the melting point of the resulting absorber (ACIGS), thus allowing its deposition at relatively low temperatures. This provision eliminates the bottom cell damage while adapting ACIGS as a top cell in a tandem configuration. The project also investigates defects in ACIGS and their mitigation by implementing adequate passivation strategies. The solar cell device architecture will be tailored to yield high open-circuit voltages reducing the non-radiative losses across the absorber/buffer layer interface. Drift-diffusion simulations will be carried out connecting the materials properties, defects, and recombination mechanisms with the observed experimental results. The small-scale ACIGS devices fabricated in the laboratory will be scaled up at the industry partner fabricating mini-modules. The expected project results have the potential to be a major milestone in the development of tandem PV and to be readily exploited in industry.

Keywords: thin film solar cells,photovoltaics,tandem solar cells
Coherent, Acceptable, Low Emission Cultural Heritage Efficient Renovation (CALECHE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Research and Innovation actions
Partnership: B4P (co-programmed)
Countries involved: France,Italy,Sweden,Switzerland,United Kingdom,Ireland,Greece
Call: Sustainable and resource-efficient solutions for an open, accessible, inclusive, resilient and low-emission cultural heritage: prevention, monitoring, management, maintenance, and renovation (Built4People) (HORIZON-CL5-2022-D4-02, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 4328568.0
EU funding (EUR): 4328568.0
Participants: 18
Project status: SIGNED

Historic buildings represents a considerable share of the European building stock (around 25%). They contribute to the identity and uniqueness of many cities and will only survive if they are maintained as a living space. To preserve a living built heritage, it is necessary to find energy renovation approaches and solutions compatible with conservation rules. This means that the historical and aesthetic value of these properties must be preserved while increasing the comfort of these living spaces, and minimizing their energy consumption and their environmental impact. The project aims to establish new knowledge for the development of sustainable and efficient solutions for historic buildings in order to bring cultural heritage to life and make it open, accessible, inclusive, resilient and low-emission. It is part of the pursuit of various projects involving members of the CALECHE network concerning, for example, bio-sourced renovation or "custom" PV integration. The studied solutions will cover all stages of operation (prevention, monitoring, maintenance) and renovation (setting up the operation, design, works).

Keywords: cultural heritage renovation,multi benefit renovation,sustainable use of heritage buildings and districts
Anti-IgLON5 disease: From Neuroinflammation to Neurodegeneration (IGNITION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Austria,Germany,Netherlands,Italy,France,Portugal,Poland,United Kingdom,Belgium
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 3864884.14
EU funding (EUR): 3743946.36
Participants: 23
Project status: SIGNED

Anti-IgLON5 disease is a recently described encephalopathy associated with a variety of neurological symptoms that can be life-threating. The clinical course is mainly chronic and the response to immunotherapies is suboptimal. The hallmark of the disease is the presence of antibodies against IgLON5, a cell adhesion molecule predominantly expressed on the neuronal membrane. Surprisingly, neuropathological findings on autopsies revealed the presence of an atypical neuronal brainstem tauopathy, establishing a link between neurodegeneration and IgLON5 antibodies. IGNITION aims to establish an innovative, interdisciplinary doctoral training program to foster the next generation of scientists at the interface of neuroinflammation and neurodegeneration. The unique program will train 13 Doctoral Candidates across four key objectives: 1) addressing clinical challenges in diagnosing and managing anti-IgLON5 disease, 2) investigating the role of neuroinflammation in neurodegeneration, 3) developing animal models for therapeutic testing, and 4) analysing the function of IgLON5 in health and disease. These objectives will be pursued using cutting-edge molecular, cellular, and in vivo techniques, offering a comprehensive research training experience with the support of leading biotech and diagnostic companies. IGNITION will advance our understanding of the mechanisms behind anti-IgLON5 disease, contributing to scientific innovation and providing tools for improved diagnosis and prognosis. The gained insights will extend to the broader field of neurodegeneration, offering potential breakthroughs for other tauopathies, including Alzheimer’s and Parkinson’s disease. Through its research and training activities, IGNITION will foster scientific excellence, increase disease awareness, and provide societal and economic benefits through the development of new diagnostic and therapeutic strategies across Europe.

Keywords: anti iglon5 disease,autoimmunity,neurodegeneration,inflammation,encephalopathy
A novel 3D printEr for lArGe-area light-based additive manufacturing with uLtra-high rEsolution combining digital light procEssing and two-photon polYmErization (EagleEye)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 153486.72
EU funding (EUR): 153486.72
Participants: 2
Project status: CLOSED

The processing of photosensitive materials upon the exposure of focused femtosecond laser radiation is referred to as two-photon polymerization, a powerful light-based Additive Manufacturing technique to fabricate 3D microstructures with ultra-high resolution. Nonlinear phenomena convert photoresists or resins into the solid phase, whereby the process area is confined to the laser focus in which a solid building block is created with a possible size down to sub-100 nm. In this way, two-photon polymerization enables the direct writing of arbitrary 3D structures by guiding the laser focus through the material. However, the writing scheme of two-photon polymerization is highly time-consuming. Thus, the technique has been unsuitable for large-area manufacturing of real-world products so far. This research aims to engineer a novel, fully automated 3D printer that combines one-photon printing by digital light projection and two-photon polymerization. In this way, the novel 3D printer will allow using the 3D structuring capabilities of two-photon polymerization on a large area. Thus, this project will enable the lab-to-fab transfer of light-based Additive Manufacturing with an ultra-high resolution that will open new pathways to produce novel real-world devices, especially for healthcare. In this context, biodegradable and biocompatible resins will be employed. The efficiency of two-photon polymerization will be further enhanced by digital mask projection using a digital mirror device, the same technique that is used for digital light processing. In addition, the printing process will be optimized using machine learning/artificial intelligence. A software will be developed to set the necessary printing settings. The produced structures will be analyzed using scanning electron microscopy. Finally, the novel 3D printer will be used to manufacture novel real-world devices for tissue engineering and Lab-on-Chip applications that will be characterized and tested afterwards.

Keywords: 3d printing,additive manufacturing,digital light processing,two photon polymerization,tissue engineering,lab on chips
Space-time visualization of photo-excited carrier dynamics in ferroelectric solar-energy converters by ultrafast electron microscopy (SpaceTimeFerro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Giant bulk photovoltaic effect in non-centrosymmetric ferroelectric materials is currently gaining tremendous research interest due to its above-bandgap photovoltage and the observed output voltage is around 3-4 orders of magnitude higher than the Si-solar cells. Hence, the ferroelectric photovoltaic response is considered the next-generation photovoltaic device. However, researchers currently lack a profound understanding of the exact mechanism of the bulk photovoltaic effect, and the proposed mechanisms are contradictory to each other. This, in turn, restricts the progress of the field towards efficient solar cells. The difficult part of finding the exact mechanism is due to ultrafast carrier dynamics and atomic relaxation times are of the order of ≈ 0.1 to 10 femtoseconds, which made it experimentally inaccessible. At present, the excellent infrastructure and facilities of my host institute dealing with the ultrafast carrier dynamics can record the meticulous dynamics in space-time resolution and hence can provide the exact mechanism towards the above bandgap photovoltage in the ferroelectric system. Therefore, through this project, we are going to investigate the origin of the anomalous bulk photovoltaic effect in perovskite ferroelectric oxides by “filming” the ultrafast photo-absorption and subsequent photo-excited carrier relaxation dynamics with femtosecond time resolution and nanometre spatial resolution using laser-driven electron microscopy. In contrast to the spectroscopic approach, ultrafast electron pulses in a femtosecond electron microscope or diffraction apparatus can provide nanometre spatial and femtosecond temporal resolutions at the same time and hence can provide a movie of evolving electromagnetic field in space and time. Based on the data generated, a comprehensive physical mechanism will be put forth, which will act as guidance for the selection and design of future ferroelectric systems for an improved photovoltaic response.

Keywords: ultrafast microscopy femtosecond laser ferroelectric photovoltaic nonlinear optics terahertz radiation thin films
Early detection, molecular mechanisms and therapeutic interventions in chronic kidney disease (ELIMINATE-CKD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The objective of ELIMINATE-CKD is to demonstrate that combining measures of kidney structure and function will strongly enhance detection of chronic kidney disease (CKD). To reach this objective, I will develop a new method to quantify the number of nephrons, the smallest functional units in the kidney. Rationale: - CKD affects ~10% of the global population and causes 2.6 million deaths/year. CKD-associated costs (140 billion euros/year in Europe) exceed diabetes and cancer. Limitations in CKD detection impede the success of emerging therapies. - Current CKD definition is based on creatinine-based estimated glomerular filtration rate, which is often inaccurate due to interindividual differences in body composition and compensation for early kidney damage as remaining nephrons increase their function. - Using a unique combination of multi-omics and machine learning approaches in human cohorts and innovative animal models, I will dissect pathways that drive nephron number and enable its quantification. Concrete objectives are to: 1) Develop a high-throughput method to quantify nephron number in large human cohorts and a novel rat model of gradual nephron reduction 2) Construct and validate unbiased and hypothesis-driven nephron number algorithms based on kidney-derived proteins, lipids and metabolites in blood and urine 3) Demonstrate that nephron number algorithms enable earlier and more accurate CKD detection 4) Provide proof of principle that nephron number-triggered therapy prevents or halts CKD Impact: This project will lead to a new CKD classification, based on both structure and function. Identification of mechanisms driving nephron number will boost drug development and regenerative medicine towards nephron-preserving therapies. Finally, the concept of structure-function relationship is relevant in many other organs (brain, heart). My passion to beat kidney disease by innovative diagnostics drives me towards my ultimate goal: to eliminate CKD.

Keywords: chronic kidney disease,kidney function,biomarker epidemiology,machine learning,resilience