Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Resilience of Opportunistic Networks to Node Misbehaviors (RETUNE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 188631.6
EU funding (EUR): 188631.6
Participants: 1
Project status: CLOSED

Whereas there has been considerable work in the DTN community on the design and analysis of different data forwarding algorithms, much less attention has been paid to the associated security and cooperation issues (ref. Section B1.1.1). In particular, there is limited work on the resilience of these schemes to node misbehaviors. Nodes might defer from participating in the data forwarding process, in order to either not spend their (limited) resources for relaying data of no interest to them (selfishness) or sabotage (certain) data transfers (maliciousness). Even less has been reported in literature on countermeasures to such node misbehaviors, so that their impact be contained and a certain (minimum) performance level be possible. The candidate Fellow argues that resilience should be a major design objective for protocols and mechanisms designed for opportunistic networking besides the more standard performance-oriented objectives (throughput, delay, resource consumption). Rather than a posteriori assessing the efficiency of schemes designed under the optimistic and frequently false assumption of perfect node cooperation, he argues in favor of a priori accounting for the (highly likely) lack of it when designing a scheme. As such, the resilience of opportunistic networking to node misbehavior should be addressed in parallel with the other research work on these networks, should these schemes ever be widely deployed and avoid the fate of the ad hoc networks. The research proposed in the context of this fellowship aims at addressing this need, promoting resilience aspects to visible elements in the opportunistic networking research agenda, and producing knowledge and results that will increase the attractiveness of and confidence in the deployment of opportunistic networking solutions.

Keywords: opportunistic networking,delay tolerant networks,node misbehaviours,selfishness,denial of service attacks,modeling,performance evaluation,markovian chains,mobility modeling,resilience
Building capacity for testing genetic vector control measure against the tiger mosquito Aedes Albopictus (BLOCKTIGER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2011-09-02
End date: 2013-09-01
Duration (months): 24.0
Total project cost (EUR): 222272.4
EU funding (EUR): 222272.4
Participants: 1
Project status: CLOSED

The tiger mosquito Aedes albopictus is classified as one of the 100 most dangerous invasive species in the world. Its colonization of vast region of the Asia, Europe and the American continents has not been without consequence as this mosquito species is a vector of at least 22 human diseases including Dengue, Yellow fever, West Nile Fever and Chikungunya. This alarming situation contrasts with a substantial lack of scientific knowledge and cost effective control measures. Clearly this represents a serious obstacle to stop the spread of this mosquito species to new areas of the world but also for implementing surveillance and control measures in already infested regions. Here an international expert and a leading academic institution join cutting edge expertise in genetics, molecular biology and vector control in the effort to develop and validate wild type and genetically modified mosquito strains for Sterile Insect Technique (SIT) control measures targeting Ae. albopictus. Technical skills and scientific information will be translated into novel tools for optimizing mosquito mass rearing and assessing the performance of mosquito SIT in term of cost benefit and safety under strict confined conditions that closely mimic the natural environment. The underlying project structure in terms of research activities, tasks distribution and management has been planned with the priority of facilitating the interactions of human resources, between the incoming visiting scientist and the host institution and the network of collaborating EU laboratories. This exchange of staff and transfer of knowledge will bridge the scientific and cultural differences existing between US and European laboratory working in the field of genetic vector control. The project will unleash the full potential of the collective expertise towards the objectives of the proposal and will be instrumental in building collaborative links that will extend beyond the duration of the project.

Keywords: aedes albopictus,chikungunya,control,vector-borne disease,mosquito,arbovirus,area-wide control,tiger mosquito,sterile insect technique,transgenic,gmo
Parkinson disease susceptibility gene mutations in Drosophila melanogaster and the therapeutic potential of transgenes alternative oxidase and alternative NADH dehydrogenase (DROMIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-08-01
End date: 2014-01-31
Duration (months): 30.0
Total project cost (EUR): 210035.95
EU funding (EUR): 210035.95
Participants: 1
Project status: CLOSED

Mutations in human genes parkin and DJ-1 cause susceptibility to Parkinson&apos;s disease (PD). Both genes have functions linking them to mitochondria and oxidative stress. Parkin protein is a ubiqutin E3 ligase which targets damaged proteins for proteasomal degradation and it has also been shown to localize to dysfunctional mitochondria. Protein DJ-1 has functions as a ROS scavenger and a gene expression regulator of other stress genes. My research uses Drosophila melanogaster lines with mutations in the genes parkin and DJ-1β, which are homologous to the human PD susceptibility genes. These mutant lines have characterized phenotypes displaying both locomotory defect and decreased resistance to oxidative stress. The alternative oxidase (AOX) is a gene commonly found in many plants and fungi but absent in most animals, it provides a by-pass to mitochondrial complexes III and IV. The alternative NADH dehydrogenase (NDI1) is a Saccaromyces Cerevisiae enzyme that provides by-pass the mitodhoncrial complex I. We have seen that the expression of AOX and NDI1, also at high levels, is well tolerated by the Drosophila melanogaster . We also have data demonstrating that the AOX and NDI1 proteins localize to mitochondria and that they provide resistance againts ETC inhibitors, thus making them mitochondrial antioxidants. The aim of the proposed research project is to study the pathogenesis of DJ-1β and parkin mutations in Drosophila. For this purpose I will be using in vivo fly models and primary neuron cultures isolated from the mutant and/or transgenic flies. The mitochondrial and cytosolic reactive oxygen species ( ROS) levels increased by low levels of ETC inhibitors, and my endeavor is to examine how the increased ROS levels affect the pathogenesis of parkin and DJ-1β mutations. and is there therapeutic potential in the transgenic expression of mitochondrial antioxidants.

Keywords: cytology,genetically modified organisms,gene therapy,genetic engineering,functional biology,natural sciences,neurophysiology
Tracking the Genetic Origins of the First Americans (TGOFA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 208629.0
EU funding (EUR): 208629.0
Participants: 1
Project status: CLOSED

Ancient DNA techniques will be applied to over 150 human remains from the US and Mexico corresponding to paleoamerican and amerindian populations in order to address the origin and diversification of the first inhabitants of the Americas. Second generation DNA sequencing technologies will be used to yield large amounts of genetic data of Amerindians from across Mexico and the Southwest United States. This will include the well known and controversial extinct Pericu population from the Baja California Peninsula and the Clovis site of Anzick, Montana. Complete mitochondrial genomes and nuclear SNPs will be used to compare the genetics of the presumably isolated Pericu population with contemporaneous Amerindians. In addition the genetic data of these populations will also be compared to those of the first paleoamericans (Clovis). Initially all samples will be screened using conventional PCR and amplicon sequencing on the Roche FLX platform for short fragments within the mitochondrial hypervariable region. These fragments, predominantly spanning HVS1, will be used to both assign a preliminary haplotype to each sample, and identify samples of particular interest (based on which haplogroups they fall into). Subsequently, the dataset will be partitioned into two groups. Those samples of particular interest will have the complete mitochondrial DNA genome sequenced using novel targeted-capture based sequencing. This is the first large scale genetic study to address this subject and the data obtained will be used to test different hypotheses about the colonization of America, such as the origin of the Clovis, possible population replacement events and therefore about who were the direct ancestors of the first Amerinidians.

Keywords: paleontology,population genetics,genomics,phylogeny
Towards the mechanism and function of tunneling nanotube (TNT)-dependent, intercellular exchange of cargo (FP7 TNT FUNCTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-04-01
End date: 2012-03-31
Duration (months): 24.0
Total project cost (EUR): 204568.0
EU funding (EUR): 204568.0
Participants: 1
Project status: CLOSED

Tunneling nanotubes (TNTs), recently discovered thin membrane channels connecting distant cells, represent the underlying structure of a previously unrecognized type of cell-to-cell communication. To date, a growing number of cell types have been found to use TNTs for the intercellular exchange of diverse cargoes ranging from cytoplasmic signalling molecules such as calcium ions to small vesicles of endocytic origin. During the past year, pathogens such as the human immunodeficiency virus and prions were also found to spread TNT-dependently between cells. Given the emerging wide range of implications of TNTs in the field of biomedical research, it is important to first learn the basic principles and mechanisms of TNT-dependent cell-to-cell interactions. I therefore propose to focus on three major questions: First, I will characterize the type of endocytic vesicles transiting through TNTs using flow cytometry and quantitative live cell imaging to monitor the transfer of endosomal markers (Rab GTPases) through TNTs. Secondly, using the same methodological approach, I will analyze which myosin motor(s) is (are) involved in the active transport of vesicles through TNTs. Third, by employing a proteomic screen assay, I aim at characterizing the entire set of proteins/signalling molecules transferred through TNTs.

Keywords: tunneling-nanotubes (tnts),intercellular communication,trafficking,endosomes,vesicles,rab gtpases,molecular motors,myosin,quantitative live cell imaging,proteomic screen,mass spectrometry
Quantifying Uncertainty in Climate Projections including Biogeochemical Feedbacks (CLIMB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-05-01
End date: 2013-04-30
Duration (months): 24.0
Total project cost (EUR): 165865.2
EU funding (EUR): 165865.2
Participants: 1
Project status: CLOSED

State-of-the-art earth system models used for long-term climate projections are becoming ever more complex in terms of not only spatial resolution but also the number of processes included in the models. Biogeochemical processes are just beginning to be incorporated into these complex models due to a difficulty in resolving heterogeneous biogeochemical processes. The motivation of this project is to quantify how climate projections are influenced by additional biogeochemical feedbacks that have not yet been taken into account in contemporary climate models. The researcher proposes an approach to look into coupled carbon-nitrogen-phosphorus-sulfur (C-N-P-S) cycle processes together with first-order physical processes. Biogeochemical studies show that C-N-P-S cycles are intimately interlinked via biosphere, resulting in an amplification of carbon cycle feedbacks. The proposed study will treat rivers and the global coastal zone explicitly, which are known to be essential for global biogeochemical cycle but are not represented in today’s earth system models. Uncertain parameters in the model will be constrained by an inverse estimation approach using various geophysical observations during the past millennium. The project addresses the following two questions: - Do coupled C-N-P-S biogeochemical cycles reduce the uncertainty in the past and present global carbon budget? - How much do coupled C-N-P-S cycle feedbacks contribute to the future global warming? How do they affect uncertainties? The interdisciplinary study will not only have a profound implication for future climate projections but also provide a new insight into outstanding research questions that cannot be answered in individual fields alone. Our research will serve as a pilot study to inform the climate research community as to whether coupled C-N-P-S cycle processes are important to be included in next-generation climate models.

Keywords: biogeochemistry (climate change),carbon cycle (climate change),climate modelling (climate change),biogeochemistry
Deep surveying of CNV impact on Mouse transcriptome complexity and regulation (CNVIMPACTGEXP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-01
End date: 2012-10-31
Duration (months): 29.0
Total project cost (EUR): 180470.8
EU funding (EUR): 180470.8
Participants: 1
Project status: CLOSED

Copy number variation (CNV) of DNA segments has recently been identified as a major source of genetic diversity, but a comprehensive understanding of the phenotypic effect of these structural variations is only beginning to emerge. An extensive map of CNV in wild mice and inbred strains has been established by the host group. These variable regions cover ~11% of their autosomal genome. CNVs are suggested to shape tissue transcriptomes on a global scale and thus represent a substantial source for within-species phenotypic variation. In this context, we address three major research objectives all regarding the impact of structural variants on different aspects of the transcriptome. To unravel the effects of CNVs on expression at the nucleotide rather than locus level we propose to use RNA-seq to monitor expression changes of both coding and non-coding RNAs that map to or close to genomic regions that vary in copy numbers in multiple tissues of the three mouse inbred strains (129S2, DBA/2J, C57BL/6J). These will be compared to changes in the abundance of transcripts that lie outside of CNV regions. Secondly, we will use RNA-seq data to identify and characterize alternative splicing events that are either tissue- or strain-specific, as well as determine whether copy number polymorphisms affect this process. Thirdly, we will investigate allelic imbalance at genome-wide scale and check if this phenomenon is more likely to occur in CNVs. This work should (i) give an unprecedented global and precise view of the mouse transcriptome; (ii) produce the first transcriptome comparison at the nucleotide level of normal individuals of a population; (iii) help to gauge the influence of CNVs on the transcriptome and (iv) provide the first assessment of allelic imbalance at genome-wide scale.

Keywords: computational biology,genomics
Component-Based Design meets Model-Driven Engineering methodologies: improving the development of Embedded Systems (COMING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 165628.6
EU funding (EUR): 165628.6
Participants: 1
Project status: CLOSED

Embedded systems are those systems in which the software is embedded into a hardware product, ranging from mobile phones to aircraft navigation controllers. They usually must satisfy timing constraints and resource usage such as CPU, energy, memory, bus bandwidth. Model-Driven Engineering (MDE) and Component-Based Development (CBD) can be seen as two orthogonal approaches to deal with the ever increasing complexity of modern embedded systems development. The former aims at making applications resilient to technology evolutions by abstracting the business logic from platform/hardware details, while the latter promotes the reuse and recombination of already realized and validated software units. Despite the fact that the adoption of MDE mechanisms in CBD could be profitable for reducing complexity and for improving reusability, these are still prevented by the lack of a rigorous formalization of CBD concepts into the MDE field. This project aims at joining complementary expertise gained by the hosting organization in CBD of embedded systems and the state-of-the-art knowledge in MDE techniques carried in by the research fellow. The expected outcomes are manifold, both from the researcher and the hosting organization sides, notably: - advance of the current state-of-the-art methodologies devoted to embedded systems development; - development of new skills for the research fellow; - enrichment of the education and training activities provided by the hosting organization to both students and industrial partners; - integration of researcher&apos;s activities into the host environment to build up a career advancement path.

Keywords: software engineering,model-driven engineering,component-based design,embedded systems,software analysis,software verification & validation
Dynamics of Soft Metallo-Supramolecular Materials from Entangled Macromolecular Precursors (SUPRA-DYN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 159600.0
EU funding (EUR): 159600.0
Participants: 1
Project status: CLOSED

Our project deals with the class of supramolecular systems coined “metallo-supramolecular polymers”, which offer several advantages compared to their covalent counterparts, e.g. a “self-healing” mechanism due to the reversibility of the supramolecular bond. The specific systems based on metallo-terpyridine complexes binding covalent macromolecular precursors, which have been developed at University Catholique de Louvain (UCL) [Guillet et al. (2009)] provide unique tunability and simplicity making them ideal model systems to test supramolecular dynamics and stimuli responsive behavior on well defined supramolecular architectures, such as stars or hierarchically branched structures. The host at UCL has great expertise and a number of collaborations on advanced polymeric systems, e.g. telechelic polymers, ionomers as well as supramolecular systems, and the work will benefit tremendously from this strong theoretical and materials support. The applicant brings a very beneficial research experience in structure-property relationships of polymeric systems, in various and partly combined experimental techniques, such as rheology with combined scattering or nuclear magnetic resonance (NMR) as well as in molecular modelling, which will allow a productive research focused on the “tunability” of materials. The opportunity to locally team-up with experts in the field of molecular modelling, materials characterization and synthetic organic chemistry provides an excellent perspective for an interdisciplinary approach in the proposed project. Thus, the applicant will be able to develop a strong expertise in polymeric systems and soft condensed matter.

Keywords: macromolecular chemistry,polymer chemistry,soft matter and polymer physics,supramolecular systems,rheology