Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Effective Monitoring and Modelling solutions for data-driven hOlistic management of URBAN water quality (URBAN M2O)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Innovation actions
Countries involved: Denmark,Italy,Austria,Belgium,Spain,Switzerland,Portugal,Netherlands,France,Germany
Call: Holistic approaches for effective monitoring of water quality in urban areas (HORIZON-CL6-2024-ZEROPOLLUTION-02, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 5847468.75
EU funding (EUR): 4999999.77
Participants: 20
Project status: SIGNED

URBAN M2O aims to create solutions to generate the crucial information that is needed to develop and implement risk-based urban water quality management plans at the city scale. Such plans will contribute to achieving sustainable urban water systems with zero pollution impact on human health and the environment. URBAN M2O will achieve this objective by: 1) Developing and benchmarking AI-enhanced, resource-effective monitoring water quality technologies; 2) Developing fit-for-purpose water quality models and harmonized data management systems; 3) Demonstrating open-access urban water digital twins assimilating monitoring data to identify hotspots and prioritize pollution control actions under current and future climate scenarios; 4) Providing tailored guidance to end users and stakeholders for the effective development of urban water quality monitoring and management plans. Industrial partners will enhance their monitoring techniques with AI methods, benchmarking them against state-of-the-art monitoring approaches for trace organic chemicals, microbial contaminants, and microplastics in all urban water systems, namely drinking water, surface water, bathing water, wastewater effluents, groundwater, urban run-off, and sewer overflows. Monitoring and modelling solutions will be demonstrated in three real and operational case studies, selected to represent different challenges faced by urban water infrastructure. The URBAN M2O solutions will be tailored to stakeholders and end-users’ needs, addressing current and future requirements and challenges, and different resources and data availability. URBAN M2O will enable urban water managers and regulators to make informed decisions, prioritizing actions to enhance urban water quality, and protect human health, the environment, and biodiversity at the European scale.

Keywords: data management systems,sensor benchmarking,digital twin,risk based pollution control
Electrochemical Nitrate Reduction to Ammonia and Organic Pollutant Removal from Wastewater in a Bipolar Membrane Electrolyser (ENRAOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Water scarcity and contamination are the major challenges threatening the human health and sustainable development of our society. One of the utmost concerns comes from the imbalance of the global nitrogen cycle due to anthropogenic nitrate water contamination. High concentrations of nitrate in water bodies can cause eutrophication issues, leading to negative effects on biodiversity, fisheries, and recreational activities. Similarly, the contamination of freshwater systems by chemical compounds such as micropollutants (MPs) and per- and polyfluoroalkyl substances (PFAS) from industrial and human activities is also receiving significant public attention. These organic pollutants are believed to raise considerable toxicological concerns, even though most are present at low concentrations in the environment. Eliminating pollutants from water using electricity is becoming an attractive approach for water treatment. Meanwhile, electrochemical nitrate reduction to ammonia (NH₃) (NO₃RR) using renewable energy has gained intensive interest as a method to close the nitrogen cycle. This research project, undertaken at Institut Européen des Membranes (IEM), aims to integrate nitrate reduction to ammonia with the removal of micropollutants/PFAS from both drinking water and wastewater in a bipolar membrane electrolyser. This advanced, highly synergistic system is poised to tackle two of the most pressing global challenges—energy-efficient ammonia production and the water scarcity crisis—simultaneously. By converging the processes of nitrate reduction and micropollutant/PFAS elimination into a single operation, our proposed method not only signifies a leap towards mitigating climate change effects but also promises a substantial enhancement in water quality, addressing the urgent need for safe and accessible water.

Keywords: nitrate reduction,ammonia electrosynthesis,water treatment,micropollutants,electro oxidation,pfas,electrochemical treatment,bipolar membrane electrolyser
Development of artificial phosphoinositides aiming at HIV eradication (Super-HIPPO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-10-31
Duration (months): 26.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: SIGNED

Main challenge of fighting with the HIV is to eliminate the latent viral reservoir from the body. This reservoir is resistant to antiretroviral drug therapy and can cause viral rebound if the treatment is stopped. The removal of the reservoir enables HIV eradication, is urgently desired in HIV-AIDS research. For this purpose, a strategy called “kick and kill” was proposed, based on the hypothesis that activation of latent HIV (“kick”) leads to cell death (“kill”) by physical damage and/or immune activation. However, in clinical tests “kill” process was found to be not enough to reach HIV eradication. To eradicate HIV from the body, my work has recently suggested a new strategy called “lock-in and apoptosis” instead of “kick and kill”. In development of this strategy, non-natural derivative of inositol hexaphosphate (IP6) named as L-HIPPO was designed based on the fact that the MA domain of Pr55gag which mediates membrane binding through its interaction with inositol phospholipid PIP2 in the host membrane. L-HIPPO was administrated to HIV infected HeLa cells as complex with a carrier α-CDE and suppressed membrane localization of HIV-1 Gag protein and induced strong apoptosis of the host cell containing the latent viruses. In contrast, α-CDE-L-HIPPO induced less apoptosis on T cell line. Besides, the complex of α-CDE-L-HIPPO is inapplicable for oral use. Toward this end, new L-HIPPO derivative with alternative carrier is required. An ultimate goal of this work is to develop new L-HIPPO derivative (Super-HIPPO) with more potent and efficient activities. My objectives to reach this goal are (1) to synthesize new L-HIPPO derivatives and alternative carriers, (2) to evaluate their activities, (3) to repeat design, synthesis and biological evaluation, if the activities are not enough, (4) to confirm the binding mode of MA-compound, and (5) to achieve personal development and career advancement by performing this study.

Keywords: inositol hexaphosphate,nanoparticles,hiv 1,matrix protein,and x ray crystallography
Avicenna Live: The Immediate Context of Avicenna’s Intellectual Formation (ALIVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands,Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499516.0
EU funding (EUR): 1499516.0
Participants: 2
Project status: SIGNED

Avicenna (Ibn Sīnā, d. 428/1037) is among the most influential philosophers in history and the most important philosopher of the Islamic tradition. He is described as a Mozart-type Wunderkind, who very early had completed his education and perfected his understanding of reality. Yet, throughout his life, Avicenna was also an eager student of his teachers or himself a dedicated teacher to his students – leading to the key-question of ALIVE: to what extent have Avicenna’s personal relations with his peers influenced the formation and formulation of his own philosophy? Did he reform or reformulate his thoughts in light of his personal interactions? Modern scholarship on Avicenna has often evaded these questions, frequently referring to his autobiography, according to which he supposedly never added anything to his views after his eighteenth birthday. What is more, scholars appear either unaware of the existence of sources that allow the examination of Avicenna’s potential indebtedness to and interaction with his peers or deterred by the challenges involved in exploring them systematically. As a result, the immediate context of Avicenna’s intellectual formation remained a surprisingly understudied area of research in defiance of its enormous potential for new insights not only into particular parts of his oeuvre but into his philosophy as a whole. ALIVE offers a radically new way of approaching Avicenna by studying four unique source texts that enable us to “circle in” on his intellectual upbringing and development, thereby providing an entirely novel paradigm for all future investigation in the field. At the same time, ALIVE will make an important contribution to the Digital Humanities by furnishing an online platform that will facilitate the study of diverse and difficult textual corpora for both ALIVE and future projects sharing these challenges.

Keywords: arabic islamic philosophy,digital humanities,avicenna
Museum Artwork Sustainable Technology for Energy Efficiency and Conservation Enhancement (MASTERPIECE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 2
Project status: SIGNED

The MASTERPIECE project aims to create a transformative change in the conservation of Wooden Panel Paintings (WPPs) from the Middle Ages and Renaissance, integral to our shared cultural heritage. These artworks are susceptible to environmental conditions like humidity and temperature fluctuations, challenging traditional conservation methods. The project proposes an innovative approach by integrating energy-efficient climate control and advanced digital modeling to optimize both preservation and sustainability. Traditional climate control systems in museums contribute to an unsustainable energy footprint. MASTERPIECE addresses this by using adaptive climate control strategies that take into account the unique needs of each artwork. Through collaboration with the Getty Conservation Institute (GCI), a leader in art conservation, the project will develop 'digital twins'—digital replicas that simulate the artworks' hygro-mechanical behavior in real-time. Rather than focusing solely on vulnerability, MASTERPIECE introduces the concept of resilience through 'fragility-resilience curves.' These curves enable a nuanced understanding of how artworks respond to environmental stressors, informing targeted and effective conservation strategies that harmonize with energy efficiency goals. The project will unfold in two key phases. The first phase at the GCI will focus on creating the digital twins and fragility-resilience curves. The second phase will conduct mechanical characterization tests on historical paintings to validate and refine these models, ensuring their broader applicability and impact. MASTERPIECE aims to redefine standards in art conservation by offering an interdisciplinary solution that harmonizes the need for energy-efficient practices with effective long-term preservation. By integrating advanced technologies with conservation science, MASTERPIECE aspires to make a lasting, positive impact on global art preservation strategies.

Keywords: heritage science,wood science,cultural heritage conservation
Breakthrough enzymatic synthesis technology for ultra-pure, ultra-long and affordable industrial production of ssDNA sequences. (Moligo)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Moligo Technologies (Moligo) is a spinoff from Karolinska Institute (Sweden) with a proprietary enzymatic DNA synthesis platform enabling cost- effective production of single stranded DNA (ssDNA) molecules at an unprecedented purity, length, complexity, and scale. Through such a platform, Moligo aims to revolutionise the multiple sectors in which ssDNA finds application, focusing on the most receptive sector first (Cell and gene therapies) where Moligo’s technology holds breakthrough potential over the current DNA synthesis methods. Traditional ssDNA synthesis approaches in fact rely primarily on chemical processes and are unable to meet the standards of purity, length, and scale necessary for the widespread implementation of gene therapies and technologies. EIC support is sought after to accelerate the achievement of a scaled up production capacity according to GMP standards for multiple ssDNA sequences to ensure a stable supply of ssDNA for a variety of end-customers, as well as expansion of our technology capability to drive optimised sequences in a short time. These steps will be essential to both capture our business opportunity and attract a growing number of customers in the Cell and Gene Therapy market. Successfully expanding through this entry point, together with the growth of the DNA synthesis platform and the availability of large quantities of ultra-pure DNA molecules at a highly competitive price point will also facilitate the capture of new market opportunities across other industries.

Keywords: dna synthesis,ssdna,cell and gene therapy
Truth in Ancient and Medieval Philosophy (TAMP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1487023.75
EU funding (EUR): 1487023.75
Participants: 2
Project status: SIGNED

While it is sometimes suggested that we are living in a 'post-truth' age wherein the concept of truth is increasingly less relevant, truth nonetheless remains a central concept in science, ethics, and ordinary life. However, what precisely is truth? One common view, the so-called 'correspondence theory of truth', maintains that truth is simply correspondence with the facts. However, such a view faces a number of difficulties and potential objections. For instance, what exactly is correspondence? And what exactly are facts? Moreover, if truth is simply correspondence then why it is the case that correspondence comes in degrees whereas truth is usually agreed not to? And how should we deal with certain semantic paradoxes, such as liar paradoxes, which suggest that our conceptions of truth are internally inconsistent? The notion that truth consists in correspondence goes back to antiquity and the Middle Ages. However, although past philosophers discussed the nature of truth in significant detail and with considerable philosophical sophistication, our understanding of past theories of truth is surprisingly limited and we lack a clear idea of how notions of truth developed in later antiquity or in the Arabic and Latin medieval traditions. This project will offer the first focused and systematic examination of philosophical conceptions of truth in ancient and medieval philosophy. It will examine the origins, motivations, and challenges faced by conceptions of truth in this period and how these challenges led to the development of alternative theories of truth. By holistically examining both 'major' and 'minor' figures and texts in this period and combining metaphysical approaches to truth with logical and semantic approaches, this project will offer us a better understanding of a central philosophical issue across the Greek, Arabic, and Latin traditions and greater insight into an extremely rich but often neglected period of philosophy.

Keywords: correspondence theory of truth greco roman philosophy arabic philosophy medieval latin philosophy metaphysics philosophy of language logic semantics
Smart Ultraviolet Radiation Filters (SMART UV)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 2474837.75
EU funding (EUR): 1728011.0
Participants: 1
Project status: CLOSED

Over 3M new cases of skin cancer occur annually, with 85% related to sun exposure, hence widely preventable. Sunscreens are key players for skin cancer prevention protecting us from the UVR due to their active ingredients: UV filters. Regrettably, existing filters have limitations: Fast degradation; Toxic to humans/sea environment; Limited exposure time; Require combination of multiple filters for full UV spectrum protection. Roka Furadada has developed and patented SMART UV overcoming all those limitations: non-toxic, long-lasting, UVR-dose dependent and eco sustainable (lignin as raw material) promoting circular economy. Our goal is to make SMART UV the first choice for sunscreen manufacturers and users that wish to protect their skin without harming the environment. The EIC Acc will help bring SMART UV to market, optimizing scalability, sustainable synthesis, completing lab tests, and obtaining cosmetic ingredient certifications. Roka expects to breakeven by 2024 with sales of €4M.

Keywords: photochemistry,skin cancer prevention,cosmetics,uv filters,sunscreens
A Precipitationshed Approach to Changing Extremes (PACE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Characterizing the frequency of future precipitation extremes is a fundamental task in order to understand and mitigate their effects under future climate conditions. However, predicting these changes is a challenging task as intense rainfall is poorly represented in climate models, and extrapolations based on historical data are highly uncertain. The objective of the PACE project is bridging this disconnection by developing an innovative physically-informed statistical model for rainfall extremes. The proposed methodology explicitly accounts for the interannual variability of atmospheric moisture fluxes and their future predicted changes. PACE will achieve this objective by using an innovative precipitationshed perspective. Precipitationsheds - the regions of Earth from which most precipitable water originates before reaching a target site – will be computed using a moisture tracking technique. By including in the statistical representation of rainfall extreme key physical information integrated over a precipitationshed, PACE will provide a novel representation of how dynamic and thermodynamic changing conditions in upwind areas affect the frequency and probability distribution of downwind precipitation. By learning rainfall statistical properties from historical data and relying on climate model predictions only for large scale climate features, the PACE action will improve probabilistic rainfall predictions under future climate scenarios. The Candidate, recently graduated from Duke University (Durham, NC) will join the Host at TU Delft (Delft, The Netherlands) to achieve this research objective, and to continue his postgraduate professional development aimed at creating an independent research program in hydroclimatology.

Keywords: extreme rainfall hydrology hydrometeorology