Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIOfilm-REsistant Materials for hard tissue Implant Applications (BIOREMIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Spain,Italy,Germany,Ireland,Germany,Greece,Sweden,Switzerland,France,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 4029973.56
EU funding (EUR): 4029973.56
Participants: 11
Project status: SIGNED

Implant-associated infections, commonly caused by biofilm-forming bacteria, are highly problematic for the patient, the healthcare system, and society. BIOREMIA will recruit 15 doctoral students (ESRs) and provide a highly inter-disciplinary joint research & training programme focused on the key issues that determine the future antibacterial biomaterials and technologies for orthopaedic and dental applications. BIOREMIA links 7 academic and 4 non-academic beneficiaries as well as 6 partners from 11 European countries (Germany, Austria, Greece, Sweden, UK, Spain, Italy, France, Switzerland, Ireland and the Netherlands) and the USA. The ESRs will be supervised and trained by world-class academic and industrial organisations, combining technical knowledge with hands-on training in state-of-the-art research projects. BIOREMIA training program will include face-to-face and online scientific courses in biomaterials & surface engineering, biotechnology,nanotechnology, implant manufacturing, biochemistry, microbiology and biofilm. This will be complemented by education in transferable skills such as entrepreneurship, management, IPR, communication etc. useful for getting an innovation-oriented mind-set of young researchers. Participating in BIOREMIA will make PhD students highly attractive for employers and open up doors for their successful careers in research, regulation, consulting, industry and the healthcare system. They will be experts for the better assessment of the antibacterial functionality of materials and surfaces and for delivering successful strategies for the medical device industry and the healthcare system. The strong involvement of the industrial sector will provide the ESRs with a holistic perspective on career opportunities. Beyond the trained researchers, this network will produce innovative materials and technologies that will enhance the productivity of European industry and improve the well-being of European citizens by minimizing implant-associated infection rates.

Keywords: metallic biomaterials,ti alloys,metallic glasses,antibacterial coatings,nanostructured surfaces,biomedical engineering,corrosion,biocompatibility,implant,biofilm,in vitro testing
Supporting innovation in traditional companies (TRADINN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Italy,Bulgaria,Poland
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2019)
Start date: 2020-09-01
End date: 2021-06-30
Duration (months): 10.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

Innovative solutions are often combined with companies operating in the modern technologies industry, highly automated production companies or start-ups launching products and services based on the latest research and discoveries. Meanwhile, the market is dominated by companies offering traditional solutions that do not show, at first glance, the perspective of transformation towards broadly understood innovations. The belief in the lack of development opportunities by implementation of significant changes in traditional businesses is the reason for the stagnation, shrinkage and even the collapse of many SMEs in Europe. Traditional companies are enterprises operating in industries that have been operating on the market for several dozen or even several hundred years, e.g. agriculture, forestry, construction, gastronomy and hotel industry, education, legal or accounting activities, as well as the activities of libraries, archives, museums and various types of transport services. The degree of their modernity and approach to the implementation of innovation often opposes modern industries related to broadly understood digitalisation and based mostly on the latest knowledge, such as IT, IoT, AI, AR, VR, drone industry, telemedicine or even hydroponics in favor of these others, of course. Although effective combinations of innovations with traditional services or products, such as thermoactive clothing, on-line food stores, train simulators or foot scanners in shoe stores are already well known, entrepreneurs' willingness to develop towards new technologies is still small. The reason may be the lack of awareness of existing solutions and technological possibilities. The goal of the project is to develop a strategy for promoting innovation in such business, that could be implemented by business environment organisations.

Keywords: traditional,innovative,transformation,solutions,development
Real-time up-conversion luminescence thermometry based on lanthanide doped nanodiamonds in a living cell (RULE-THERM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: TERMINATED

This project will develop a novel thermometer based for intracellular temperature sensing application. Success will bring real-time high-resolution probing and imaging of temperature within living cells to the research community; this can promote novel insight about the pathology and, in turn, help establish a powerful tool in terms of its potential to support early diagnoses and therapies in a broad range of disease areas. In this respect the RULE-THERM project aims to contribute a foundational development of a technology with potentially wide applicability. The project brings together a talented young Fellow with a strong nano-science background and an internationally growing group of researchers at Aston University with expertise in diamond-based materials, which offer excellent biocompatibility and thus have a great potential for cellular interface.

Keywords: up conversion luminescence,cellular probe,intracellular sensing,nanodiamonds
Characterising plant interactions with bacteria that promote the uptake of nitrogen and sulphur from organic sources (PINBAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The plant rhizosphere contains an abundant and diverse array of microbes, and plants interact with this microbial community in diverse ways, from mutualistic to neutral to pathogenic . It is proposed that future agricultural systems should strategically incorporate mutualistic plant-microbe associations, whereby high-performing combinations of plant genotypes and microbial populations are co-cultivated to promote improved nutrient use efficiency and decreased fertiliser application . Currently, there is a poor scientific understanding of the precise biochemical transformations and exchanges that occur in mutualistic associations between plants and microbes, and it is also unclear which specific microbial species are the most effective for supporting plant growth and nutrition. There is evidence that plant genotypes exhibit differing capacities to shape their rhizospheric microbiome , but our poor mechanistic understanding of this phenomenon prevents breeding strategies to select crop varieties that will host favourable microbial interactions. Therefore, this project proposes to address these gaps in scientific knowledge, by undertaking co-cultivation experiments that investigate which specific bacterial species are most effective for enhancing plant uptake of nitrogen (N) and sulphur (S) from organic sources, as well as which specific Arabidopsis accessions are the most receptive hosts for these interactions. Next, isotope labelling and metabolic flux studies will be undertaken in the best and worst performing plant-microbe combinations, to define the specific biochemical routes of N & S transfer that are favourable for plant nutrition. Also, genetic investigations will be undertaken to find the key genes responsible for favourable plant-microbe interactions. This project combines the complementary expertise of its participants to deliver high-quality training to the researcher, which will enhance his professional maturity in this strategically important field.

Keywords: plant microbe interaction,plant nutrition,metabolic fluxes
Targeting the Anti-Target: From Structure to Drug in the heart Kv11.1 channel (HeartAtaK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Potassium channels are widely distributed and have many important biological functions in the human body. Of special interest is the Kv11.1 channel, whose main function is the repolarization of the membrane after a cardiac action potential. Unfortunately, this channel can be blocked by a variety of structurally diverse drugs causing the long QT syndrome (LQTS), a cardiac repolarization disorder that can lead to arrhythmia and sudden heart death. Due to this very severe side effect, a variety of drugs with otherwise good therapeutic profiles have been withdrawn from the market. Nowadays, cardiac Kv11.1 is an important anti-target in drug development to exclude any potential side effects that could lead to LQTS. In contrast, tumour cells require the expression of specific isoforms of Kv11.1 for survival making these channels a potential anti-cancer drug target – as long as these drugs do not bind to the heart isoform. The major goal of this project is the elucidation of the structure of Kv11.1 via X-ray crystallography or cryo-EM. I have established large-scale protein production of a Kv11.1-chimera using the baculovirus/insect cell expression system, thus enabling biophysical and structural studies to provide structural information on a range of time- and spatial resolution scales. This will not only shed light on the structural motifs responsible for binding a variety of structurally diverse drugs but also improve the fundamental knowledge for the understanding of the special biophysical properties of this channel. By taking these techniques together I will be able to determine how known inhibitors bind, and so identify new isoform specific binding pockets to guide isoform-specific drug design. My career goal is to pursue fundamental and translational research in structural biology of human membrane protein, with a focus on medically important targets and further drug development. This project will bring me closer to that goal.

Keywords: potassium channel,drug development,integral membrane protein
Information Management Portal to Enable the inTegration of Unmanned Systems (IMPETUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Germany,Germany,Spain,Slovenia,United Kingdom
Call: Drone information management (H2020-SESAR-2016-1, 2016)
Start date: 2017-10-01
End date: 2020-02-29
Duration (months): 29.0
Total project cost (EUR): 899160.0
EU funding (EUR): 899160.0
Participants: 7
Project status: CLOSED

IMPETUS will research on the application of the ‘micro-services’ paradigm as a flexible and cost efficient solution for lifecycle support of the expected high variety of drones and missions. Moreover, IMPETUS will explore how to design an Smart UTM Concept taking into consideration the ‘Function as a Service’ paradigm to develop a cloud-based server-less environment that will be characterized by its scalability to respond to multiple users with diverse business models, its mechanisms to assure the data quality and integrity, and its flexibility to facilitate the integration with manned traffic management systems. IMPETUS consortium consists of key stakeholders that provide complementary views on the current and envisioned UTM and ATM information management processes. ALTITUDE ANGEL offers its current UTM capabilities to support recreational and commercial drone operations under VLS and its experience in previous engineering tests for B-VLS and autonomous tests. JEPPESEN, with the technological support of TU DARMSTADT, contributes with its expertise in Information Technology Services to ensure the quality of aeronautical safety-critical data. BOEING offers its expertise to analyse if SWIM standards can be used as the main bridge to exchange UTM and ATM information. INECO strengths the consortium as certified company in the commercial use of drones for bridges inspection services and with its expertise on innovative Smart solutions based on IT technologies (Big Data and Business Intelligence among others). This experience is shared with CRIDA, which is the reference research centre in integration and analysis of multiple aeronautical data sources through advanced data analytics in order to support decision-making at ENAIRE, Air Navigation Service Provider in Spain. Finally, C-ASTRAL provides a wide view and extensive market experience for diverse drone related business models, with applications in surveying, border protection or surveillance operations among others.

Keywords: unmanned systems,very low level airspace,microservices,cloud,swim
Encapsulation and contacting of two-dimensional materials (ECOMAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Two dimensional materials such as graphene and transition metal dichalcogenide (TMDC) are very sensitive to surface adsorbates and thus require proper encapsulation. In addition, functional devices based on those materials, like transistors, diodes or electro-optical modulators require high-k gate dielectrics to be deposited on top of the material. However, the deposition of high quality dielectric layers ontop of 2D materials is very challenging due to their inert surface. The project ECOMAT addresses the important challenge of depositing high-k dielectrics on top of 2D materials. In particular, the experienced researcher Dr. Barbara Canto will explore different routes to encapsulate graphene and MoS2, which is the most explored TMDC material, with different high-k dielectrics using a combination of atomic layer deposition and surface functionalization using seed layers. The key control parameters for those layers are dielectric constant, breakdown voltage, charge traps, minimal thickness achievable, and gas barrier properties, which will be characterized by electrical and spectroscopic methods. Finally a new route for fabricating low-resistive edge contacts to MoS2 will be explored, building up on encapsulated MoS2 layers. This contacting scheme is expected to significantly reduce contamination of the MoS2 layer during processing, while offering low-resistive contacts and thus will significantly increase the performance of electronic device based on MoS2. This interdisciplinary research activity builds up on the experience of Dr. Canto in the field of material science and physics and utilizes the infrastructure and knowledge at AMO on high-k dielectrics and electronic devices.

Keywords: high k dielectrics,graphene,tmdc,atomic layer deposition
A blood based biomarker identifying early Alzheimer Disease's pathology (VERDAD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-06-01
End date: 2021-11-30
Duration (months): 30.0
Total project cost (EUR): 3365416.25
EU funding (EUR): 2355791.0
Participants: 1
Project status: CLOSED

Alzheimer’s Disease (AD) poses an unbearable impact in patients’ life, through progressive loss of cognitive capacities and overall quality of life. In Europe alone, there is currently a €280 bn yearly expenditure related to AD and ~10% of the population above 65 years old is currently affected by the disease, a figure that is expected to triple in the immediate future. No treatment alternatives are available for AD patients with diagnosed disease and the existing diagnostic tools are very time consuming and expensive (6 months / 10.000 EUR). While AD is not curable at final stages of disease, detection at early stages offer several treatment alternatives for example through counseling and/or dietary interventions. Detection and treatment of AD in its initial stages could provide major therapeutic and societal benefits. Treatment strategies at early stages could either slow down or even cure AD which would dramatically reduce the health care costs. PreDiagnostics will exploit and transfer research knowledge developed by its founders to a commercial setting and provide a diagnostic tool to identify patients at early stages before disease is evident. Through the VERDAD project, PreDiagnostics will finalize the final regulatory steps and introduce into the market a novel, accurate and cost-effective blood biomarker detection tool. This tool directly analyses the patients’ brain metabolism and detects reduced clearance of beta-amyloid which is the first step in AD pathology. The VERDAD project will allow for market introduction of a disruptive diagnostic test to identify AD decades before clinical signs are visible. This will facilitate early disease diagnosis and implementation of prevention strategies in likely patients. We have developed necessary collaborations to roll-out our diagnostic tool which will lead to major costs saving for the Health Care sector, generate new employment opportunities and in unlock a revenue stream of over €1.5bn 10-years post-Project.

Keywords: alzheimers disease,blood monocytes,macrophages,immunoassay,early detection,beta amyloid
Synthetic photobiology for light controllable active matter (SYGMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Italy,Italy
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-11-01
End date: 2026-04-30
Duration (months): 78.0
Total project cost (EUR): 2397500.0
EU funding (EUR): 1018750.0
Participants: 3
Project status: SIGNED

From a Physics and Engineering standpoint, swimming bacteria are a formidable example of self-propelled micro-machines. Together with their synthetic counterpart, self-propelled colloids, they represent the “living” atoms of active matter, an exciting branch of contemporary soft matter and statistical mechanics. Differently from synthetic colloids, however, each bacterial cell contains all the molecular machinery that is required to self-replicate, sense the environment, process information and compute responses. Breaking down these biological functions into basic genetic parts has been one of the greatest triumphs of molecular biology. Today, synthetic biologists are assembling these parts into new genetic programs and exploiting bacteria as computing micro-machines. Project SYGMA will employ the synthetic biology toolkit to provide the building blocks for a light controllable active matter having reliable, reconfigurable and interactively tunable dynamical properties. We will first engineer transmembrane photoreceptors to wire RGB external light signals to cellular physical responses like speed, tumbling, growth and death rates. These genetic parts will allow the modular design of customized active particles to build active materials with unprecedented optical control capabilities. Using these new tools we will address, with experiments and theory, fundamental questions like: how fast can we drive particle density using spatio-temporal motility modulations? what is the force on a body suspended in a bath of bacteria with non uniform motility? how do physical forces contribute to morphogenesis in bacterial colonies? Finding quantitative and experimentally validated answers will eventually allow us to engineer structured illumination protocols to mold living microstructures, transport colloidal cargos by shaping active pressure, control swarms of biohybrid microcars and shape bacterial microcolonies.

Keywords: active matter