Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A citizen science decade (2020-2030) in support to the Sustainable Development Goals (CS-SDG)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Germany
Call: Conference 'A citizen science decade (2020-2030) in support to the Sustainable Development Goals' (H2020-IBA-SWAFS-Citizen-2019-2, 2019)
Start date: 2020-02-01
End date: 2021-01-31
Duration (months): 12.0
Total project cost (EUR): 254250.0
EU funding (EUR): 254250.0
Participants: 1
Project status: CLOSED

The CS-SDG project will lead to the organization of a citizen science conference which will bring together and showcase impactful citizen science initiatives, provide policy input to ongoing European developments and inspire the upcoming ten years of citizen science initiatives. CS-SDG will address this challenge by focusing on citizen science as a relevant approach to contributing to Global Challenges and industrial competitiveness in Horizon Europe, to the UN’s Sustainable Development Goals (SDGs) and to building upon ongoing initiatives in the Open Science strategy, the European Research Area (ERA) and Horizon 2020. The “A citizen science decade (2020-2030) in support to the Sustainable Development Goals” conference will represent a crucial opportunity to bring together lessons learnt from initiatives at global, national, regional and grassroots level, to scale up their impacts, address existing challenges and harness the potential of citizen science towards achieving the SDGs. One of the main conference outcomes will be a declaration and recommendations, gathering input in a collaborative way from conference participants and selected experts, focusing on the future of citizen science and its implementation in future funding programmes. CS-SDG will organise a conference gathering policy-makers and citizen science projects – from all parts of the world, from local to global scales, and both community-led and academic-led – to build the future of citizen science policy-making. The conference will be an opportunity to showcase the diversity of citizen science projects, and a forum for reflection and perspective, with transversal sessions to define together the latest developments, impacts, benefits and challenges of citizen science, as well as a global Citizen Science Festival. Most importantly, collaborative sessions will draw recommendations to feed in strategic policy recommendations for the decade 2020-2030.

Keywords: citizen science,sustainable development,sustainable development goals,quadruple helix,institutional change,open science
Next generation breast and colorectal cancer screening through simple and accurate blood testing. (TBIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Israel
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Current methods of screening for breast and colorectal cancer are limited in availability and associated with a high cost. For example, mammography equipment for breast cancer screening is particularly limited in Eastern Europe due to the expensive equipment and the required skills that a medical professional must possess. Cologaurd’s and colonoscopy’s for colorectal cancer screening are invasive and painful procedures associated with low patient compliance (50% and 37% respectively). Furthermore blood tests that have been developed to date for cancer screening have failed to demonstrate a high level of accuracy. Todos Medical have developed a simple method for cancer screening known as TBIA (Total Biochemical Infrared Analysis). The CE-marked TBIA platform is unique being the first method using blood tests to show high sensitivity (>90%) and high specificity (>80%). It is a more cost effective and less invasive solution that is more accessible to end user and motivates increased compliance by patients. It is capable of producing results rapidly with the complete process “sample to result” taking less than 4 hours. During phase 1, a feasibility study will be carried out, together with the planning of clinical trials in hospitals that will be performed during the innovation project, to gain the validation and bring the product to the commercialization.

Keywords: in vitro diagnostic blood test,cancer screening,minimally invasive,breast cancer,colorectal cancer
Sex-limited experimental evolution of natural and novel sex chromosomes: the role of sex in shaping complex traits (ComplexSex)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1492011.0
EU funding (EUR): 1492011.0
Participants: 1
Project status: CLOSED

The origin and evolution of sexual reproduction and sex differences represents one of the major unsolved problems in evolutionary biology, and although much progress had been made both via theory and empirical research, recent data suggest that sex chromosome evolution may be more complex than previously thought. The concept of sexual antagonism (when there is a positive intersexual genetic correlation in trait expression but opposite fitness effects of the trait(s) in males and females) has become essential to our understanding of sex chromosome evolution. The goal of this proposal is to understand how the interacting effects of sexual antagonism, sex-linked genetic variation, and sex-specific selection shape the genetic architecture of complex traits. I will test the hypotheses that: 1) individual sexually antagonistic loci are common in the genome, both in separate-sexed species and in hermaphrodites, and drive patterns of sexual antagonism often seen on the trait level. 2) That the response to sex-specific selection in sex-linked loci is usually due to standing sexually antagonistic genetic variation. 3) That sexually antagonistic variation is primarily non-additive in nature. To accomplish this, I will use a combination of approaches, including sex-limited experimental evolution of the X chromosome and reciprocal sex chromosome introgression among distantly related populations of Drosophila, quantitative genetic analysis and experimental evolution mimicking the creation of a novel sex chromosome in the hermaphroditic flatworm Macrostomum, and analytical and simulation modeling. This project will serve to confirm or refute the assumption that trait-level sexual antagonism reflects the contributions of many individual sexually antagonistic loci, increase our understanding of the contribution of coevolution of the sex chromosomes to population divergence, and help provide us with a better general understanding of how genotype maps to phenotype.

Keywords: sexual dimorphism,sex chromosomes
Inline real-time 4.0 quality monitoring in food production (Food Monitor)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 1600352.5
EU funding (EUR): 1120246.75
Participants: 1
Project status: SIGNED

Nearly 67% of the food we eat is processed. With increased concern for food security, safety, traceability and the environmental impact of the food production, the industry needs to assure the quality of their products while reducing their costs. This is done mainly through lab analysis. However, despite the detail and accuracy, the results are often too late to have a real impact in the processing chain. There is no efficient means of accurately analyzing products in-line and in real-time to assure product safety, quality, increased sustainability and greater factory efficiency. Thus, there is a market opportunity for quick, precise and flexible food analysis systems. Insort GmbH is a highly specialized company for optical sorting of food products. We have been developing innovative technologies for the classification and sorting of products for the food industry since 2011. We were founded in Austria by Mr. Matthias Jeindl in cooperation with Infruits AG and EVK DI Kerschhaggl GmbH, and recently expanded our activity to several countries in Europe, the USA and Canada. Our latest innovation, the Sherlock FoodMonitor, is a food analyzer that provides the chemical composition of products in real time and at any given point of the processing chain. It allows to identify potentially dangerous substances, foreign materials, fraudulent meat, as well as variations in the inner characteristics (e.g. size, shape, dry matter, sugar, fat content). The acquired data can be used to modify parameters during processing to reduce the creation of undesired compounds and for quality assurance at any point of the line, contributing the industry 4.0 of the future. In this phase 2 project, we will improve the scanning capabilities of the Sherlock FoodMonitor to bring it to TRL9 and prepare its market launch for 2021. Our solution will enable food companies to produce safer and higher quality products, while reducing food waste and improving factory sustainability and profitability

Keywords: food monitoring,chemical analysis,composition,production line,processing,safety,food technology,machine learning,optics,food fraud
Reduced separations and improved efficiency based on Vhf cOmmunICations over LEO satEllites (VLD2 - VOICE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Belgium,Cabo Verde,Denmark,Luxembourg
Call: Optimised use of Airspace (H2020-SESAR-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 5905551.88
EU funding (EUR): 3989808.0700000003
Participants: 7
Project status: SIGNED

Communication, Navigation and Surveillance (CNS) systems are key in the provision of safe and efficient traffic management for air traffic. These systems have traditionally been ground-based and generally installed on mountain tops or at airports. Performance of these ground-based systems is limited by topography and availability of land. “New Space” and its two pillars (increasing availability and competition in the launch market increasing number of Low Earth Orbit satellites) is dropping the price of new constellations opening up for new and more cost efficient solutions in the provision of new services models. This is the case for global and seamless CNS services to be used in ATM. With requirements for Air Traffic to increase capacity and safety in the years to come, new solutions need to be deployed to ensure the correct management of Air traffic. The use of space-based infrastructure is a necessary step towards the provision of Air Traffic Services in remote areas or big sectors where they are not available today due to geographical constrains of terrestrial based systems. In this sense solutions towards the improvement of efficiency, safety and capacity of aviation, where Reduced Minima Separations in remote Airspace based on Satellite VHF Voice and Data Communications systems propose the answer. Other satellite-based technologies cannot provide a complete and integrated solution in terms of performances necessary to reduce separation. The objective of VLD2 - VOICE is to demonstrate that with the use of Satellite based VHF systems providing Voice and Datalink ATS traffic in remote airspace can be handled as in a contintenal, and current separation can be reduced non compromising safety. In addition we will perform some cross border operations between adjacent FIR belonging to different countries. Demonstration will cover operations in CANARIAS and SAL FIRs where ATCOs communcating in real time with Aircrafts at distances bigger than 1500km.

Keywords: ads b,cross border operation,flight centric,daps,cpdlc,ads c,adsp,sectorless,interoperability,shared infrastructure,ldacs,voip,separation minima,digital communicatons
Deconstructing gene regulation through functional dissection of the 3D genome (FuncDis3D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1999925.0
EU funding (EUR): 1997425.0
Participants: 1
Project status: SIGNED

The three-dimensional organization of the genome inside the nucleus (3DG) is crucial for gene regulation. Although the fundamental building blocks of the 3DG have been identified, how they contribute to gene regulation is incompletely understood. In recent years my lab has started to functionally dissect the 3DG in order to understand the effects on gene expression. The current proposal intends to expand this work and aims to i) broaden the array of proteins that are known organize the 3DG, ii) determine how loss of these proteins affects the 3DG and iii) elucidate how this influences gene expression. The key to this is to induce changes in the 3DG by acute protein depletion and measuring changes over time. We have preliminary data showing that by depleting regulators of the 3DG we can induce changes within a few hours. We will deplete a range of proteins in pluripotent and differentiated cells to determine their contribution to 3DG organization. Simultaneous characterization of the epigenome and transcriptome will allow us to determine the sequence of changes. In addition, we will perform Thousands of Reporters Integrated in Parallel (TRIP) after perturbation of the 3DG. TRIP reporters all have the same minimal promoter that acts as a sensor for promoter-enhancer (mis)-communication. By combining TRIP with 4C we can measure the changes in the reporter-enhancer interaction landscape. Our data will generate fundamental insight into the parameters that govern the interactions between promoters and regulatory elements, within the context of the 3DG, and their effects on gene expression. Furthermore, it allows us to determine the temporal order of changes in the 3DG, the epigenome and gene expression, which is essential for the establishment of cause-and-effect relationships. Collectively, our data will lead to a better appreciation of how distal and proximal regulatory regions cooperate to establish cell-type specific gene expression programs.

Keywords: 3d genome,acute protein depletion,hi c
New Frontiers for Optoelectronics with Artificial Media (FORWARD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-11-01
End date: 2024-10-31
Duration (months): 72.0
Total project cost (EUR): 1965045.0
EU funding (EUR): 1965045.0
Participants: 1
Project status: SIGNED

To detect or generate complex light beams that are increasingly needed in biology and photonics (light with non-zero angular momentum and non-classical light), it is necessary to rely on bulky and sophisticated setups, considerably limiting their potential. The FORWARD project aims at obtaining the same functionalities with a new generation of optoelectronic components of submicron thickness in the near infrared range. This ambitious objective implies to devise radically new ways of creating and manipulating complex light at the nanoscale. In FORWARD, this tremendous challenge will be addressed by hybridizing two classes of artificial media-colloidal quantum dots (CQDs) and metamaterials-and leveraging advanced cooperative behaviours within the hybrids. In the new devices, which will be pumped electrically, the active layers will be made of a film of CQDs interwoven with the metallic inclusions of an optical metamaterial. FORWARD has a strong multidisciplinary character as it lies at the crossroads of nanocrystal processing, nanofabrication, nanophotonics, condensed matter physics and optoelectronics. First, we will hybridize metallic metamaterials and CQDs, study the transport properties in these devices and develop metamaterial/CQD photodetectors demonstrating the advantage of the hybridization. Second, we will induce classical cooperative effects between the different metamaterial inclusions and utilize this approach to fabricate hybrids LEDs capable of emitting optical vortices. Last, we will induce quantum synchronizations among the CQDs and demonstrate hybrids LEDs that produce coherent and non-classical light. Each demonstrator of the project will be a world first in terms of functionalities, miniaturization and operation principle. Besides, this initiative can be seen as the first of its kind that takes a unified and multidisciplinary view at artificial media, opening new horizons for synthetic composite materials in optics, electronics and optoelectronics.

Keywords: colloidal quantum dots,metamaterials
The Orosius Arabicus and the Arab Vision of the Graeco-Roman World: Researches on the Mediterranean Responsiveness (OROARAB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Lebanon
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-08-31
Duration (months): 36.0
Total project cost (EUR): 247761.0
EU funding (EUR): 247761.0
Participants: 2
Project status: CLOSED

The very important topic of the transmission of the Greco-Roman knowledge to the medieval Islamic world has a very interesting appendix concerning historiography. Indeed, scholars have questioned several times about the reasons for the apparent Islamic lack of interest towards the western historical works, and formulated on this problem several assumptions. For example, according to Franz Rosenthal, the Greek and Roman literature, impregnated as it was of polytheism, would have been suspect in the eyes of Muslim theologians (the scientific texts, indeed, didn’t arouse objections), which would have limited its diffusion and translation. According to Bernard Lewis, everything should instead be attributed to the absolute lack of intellectual curiosity of the “Muslim man”, resulting from its profound conviction of “finality, completeness, and essential self-sufficiency of his civilisation”. In my book Storie Arabe di Greci e di Romani, released in 2009 (http://www.edizioniplus.it/italiano/AspFiles/libro.asp? codlibro=559), I tried to fill a gap in the field of studies on the forms of preservation of the Greek and Roman historiographical tradition in the Islamic culture. Now, I would like to concentrate my attention on a very important Arabic historical text, the Arabic translation of the Historiae adversus paganos by the Latin historiographer Paulus Orosius (5th century AD), known as Kitāb Hurušiyuš and survived through a unique manuscript preserved in the "Rare Book and Manuscript Library" of Columbia University (X, 893-712 H). This translation, made at the caliphal court of Cordoba in the 10th century AD, left a deep mark on Western Islamic historiography, coming to constitute for many Arab intellectuals a unique and fundamental access door to the Graeco-Roman world and to the ancient history of Europa. Therefore, my project is to prepare a complete English translation of the Kitāb Hurūšiyūš, accompanied by a broad introduction, a philological and historical commentar

Keywords: roman history,greek history,arabic philology,arabic historiography,graeco roman tradition,history of religions,islamic studies,transcultural history,latin historiography,mediaeval studies
Characterizing Congo Basin Drought resilience: an Integrative Modelling approach (COBADIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-19
End date: 2021-03-18
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The African rainforest, is the second largest on Earth, covers ~630 million ha and stores up to 66 Pg of carbon and is presently a persistent carbon sink. In addition, African rainforest support the forestry sector which contributes 3-6% of the gross domestic product across the Congo Basin with most foreign export directed to Europe. As such, African rainforest currently represents both a local and foreign economic driver and provides important ecosystem services through the negative feedback on the global carbon cycle. Both remote sensing data and tree ring stable isotope measurements have shown that these forests are currently being subjected to a long-term drying trend, raising fears over the drought resilience of tropical tree species and the persistence and magnitude of this important terrestrial carbon sink. Here, we combine eco-physiological and dendrochronological research with a model based approach to increase our understanding of the response of African tropical tree species under changing climatological conditions across the central Congo Basin. We will integrate several data streams including inventory data on soil properties and associated leaf traits, wood traits, phenology, retrospective dendrochronology and wood core stable isotope and calcium tracer time series, in order to constrain a data-informed mechanistic ecosystem model (MuSICA). Using a novel tracer experiment we will corroborate the use of a calcium [Ca] tracer in tropical tree species for rapid dating and eco-physiological research into drought resistance. Accurate model predictions, based upon Ca tracer measurements made during this action, will provide estimates of the vulnerability of tree species to future drought conditions. Our results will have important policy implications as the demise of important tree species could have significant effects on ecosystem services, e.g. affecting the carbon balance, as well as a direct economic impact on sustainable local and EU timber trade.

Keywords: dendrochronology,stable isotopes,phenology,drought resistance,african rainforests