Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
eMetabAIo: a Federated Platform and System for Real-time Quality Management and Dissemination of Biosamples and Data, Increasing Efficiency in the Biospecimen Industry (e-MetabAIo)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Greece
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 828125.0
EU funding (EUR): 828125.0
Participants: 1
Project status: SIGNED

e-MetabAIo demonstrates the benefits of combining Artificial Intelligence (AI) technologies and Internet of Things (IoT) through the formation of a holistic federated system, targeting life science, especially biobanks, healthcare providers and researchers, while placing patients in the center of the biosample and data usage chain. This patient-centric system is designed to collect, manage, analyze, store and disseminate longitudinal multisource data, in real time, connecting all stakeholders under an “all-in-one” umbrella system. e-MetabAIo enriches biosamples’ data pool while end-users are equipped with synchronized and ontologically unified tools to identify unique biosamples and patients’ profiles. Increasing efficiency and value in the biospecimen industry, basic research and personalized medicine, is accomplished by decreasing time, cost and data redundancy of the drug development cycle. The system is a real-time interactive digital environment for collaboration, harmonization and interoperability. The solution offers an AI engine, developing a deep-tech Quality Assessment system for human biosamples, based on pre-analytical multisource data records in real time, with simultaneous prediction of suitability for downstream analyses. This federated service includes a Digital Rights Management system and a consent management tool, providing exchange of biomedical data within the usage chain, using strong collective encryption, access control rights, distributed to various management points. The AI engine ranks biospecimens in terms of qualitative completeness, pre-analytical data dependent and predicts suitability based on research activity type. The AI engine observes live actions of members of the usage chain and reacts to them. Multiple systems are combined, producing a streamline state-of-the-art hub for storage and dissemination of high quality biospecimens and related data cohorts.

Keywords: semantic data integration,federated system,artificial intelligence,predictive modeling for biosample downstream analyses,biospecimen industry,digital rights management,interoperability
AI-Ops Framework for Automated, Intelligent and Reliable Data/AI Pipelines Lifecycle with Humans-in-the-Loop and Coupling of Hybrid Science-Guided and AI Models (AI-DAPT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Greece,Germany,Ireland,Portugal,Spain,Cyprus,Italy
Call: Efficient trustworthy AI - making the best of data (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 8995540.0
EU funding (EUR): 8995540.0
Participants: 18
Project status: SIGNED

AI-DAPT brings forward a data-centric mentality in AI, that is effectively fused with a model-centric, science-guided approach, across the complete lifecycle of AI-Ops, by introducing end-to-end automation and AI-based systematic methods to support the design, the execution, the observability and the lifecycle management of robust, intelligent and scalable data-AI pipelines that continuously learn and adapt based on their context. AI-DAPT will design a novel AI-Ops / intelligent pipeline lifecycle framework cross-cutting the different business, legal/ethics, data, AI logic/models, and system requirements while always ensuring a human-in-the-loop (HITL) approach across five axis: “Data Design for AI”, “Data Nurturning for AI”, “Data Generation for AI”, “Model Delivery for AI”, “Data-Model Optimization for AI”. AI-DAPT will contribute to the current research and advance the state-of-the-art techniques and technologies across a number of research paths, including sophisticated Explainable AI (XAI)-driven data operations from purposing, harvesting/mining, exploration, documentation and valuation to interoperability, annotation, cleaning, augmentation and bias detection; collaborative feature engineering minimizing the data where appropriate; adaptive AI for model retraining purposes. Overall, AI-DAPT aims at reinstating the pure data-related work in its rightful place in AI and at reinforcing the generalizability, reliability, trustworthiness and fairness of Al solutions. In order to demonstrate the actual innovation and added value that can be derived through the AI-DAPT scientific advancements, the AI-DAPT results will be validated in two, interlinked axes: I. Through their actual application to address real-life problems in four (4) representative industries: Health, Robotics, Energy, and Manufacturing; II. Through their integration in different AI solutions, either open source or commercial, that are currently available in the market.

Keywords: ai pipelines,data pipeline,data for ai,ai for data,hybrid science guided ai
Protecting the thymic epithelial cells and thymopoiesis during hematopoietic stem cell transplantation (ProtecTHY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2175054.0
EU funding (EUR): 2175054.0
Participants: 1
Project status: SIGNED

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a common, often last-resort treatment for haematological diseases, but it is plagued by long-term morbidity and high mortality. Direct alloHSCT-induced damage to the thymus and subsequent loss of thymopoiesis, ie the production of new T cells, is considered one of the main reasons for these complications. Our limited understanding of how the thymus is damaged during alloHSCT restricts the development of thymus-protecting protocols. The goal of ProtecTHY is to unravel the intrinsic protective mechanisms of the human thymus and assess how alloHSCT affects them, with the ultimate objective of devising measures to prevent thymic damage. We take advantage of an innovative whole organ culture system for the human thymus developed in my laboratory and our extensive pre-existing collection of human thymus tissue samples spanning a diverse age range. ProtecTHY specifically aims to 1) discover how the thymus protects itself from external insults over the course of the human lifetime, 2) reveal how alloHSCT disrupts the human thymus microanatomy and how that damage can be prevented with a cellular therapy, and 3) examine how thymic damage affects the circulating true naive T cells and if existing clinical treatments for alloHSCT complications can restore the loss of thymopoiesis. We will apply state-of-the-art spatial and single-cell multiomics to dissect these protective layers of the thymus both ex vivo and after alloreactive challenge in vitro. Moreover, by testing the effect of treatments already in clinical use, ProtecTHY can resolve their specific mechanisms of action and impact on the thymus. Our results are thus directly translatable to the human condition and can direct future treatments to enhance outcomes following alloHSCT. As a translational immunologist and clinical microbiologist with extensive experience in human thymus research, I am well equipped to uncover the mechanisms of thymic protection.

Keywords: the human thymus,allogeneic hematopoietic stem cell transplantation,graft versus host disease
IDENTIFYING DETERMINANTS FOR INDOOR AIR QUALITY AND THEIR HEALTH IMPACT IN ENVIRONMENTS FOR CHILDREN: MEASURES TO IMPROVE INDOOR AIR QUALITY AND REDUCE DISEASE BURDENS. (INCHILDHEALTH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Finland,Spain,Greece,Austria,Switzerland,Australia,United Kingdom,Portugal,Denmark
Call: Indoor air quality and health (HORIZON-HLTH-2021-ENVHLTH-02, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 7382288.5
EU funding (EUR): 7368144.0
Participants: 15
Project status: SIGNED

InChildHealth will integrate health, environmental, technical and social sciences research to identify determinants for Indoor Air Quality (IAQ) and evaluate their impact in environments occupied by school children. We will focus on chemicals, particle concentrations, microorganisms and physical parameters in schools, homes, sports halls and transport. The IAQ of these environments determines the dose received by the children and may directly influence their health and well-being. An environmental epidemiological study and controlled interventions conducted in schools in three European cities will assess the health effects of multipollutant airborne exposures on respiratory infections, allergies, and neurological and cognitional symptoms. In addition, dose-response will be evaluated with a novel cytotoxicity testing pipeline using in-vitro approaches. The InChildHealth consortium will cover an impressive variety of geographical and cultural diversity, with targeted exposure measurement campaigns and citizen involvement in seven European countries from Northern, Central and Southern Europe and interventions in Australia. All project?s results will converge in the InChildHealth Integrated Risk Assessment Tool, which will provide information on the interactions between the sources, emissions, concentrations, exposure, doses and disease for children. Besides, we will develop user-friendly and low-cost monitoring technologies and strategies (technical and behavioural) to improve IAQ and reduce disease burdens. InChildHealth will produce many FAIR datasets on air pollutants and their main sources for indoor environments occupied by children in different climatic and social settings in Europe. Our findings will be disseminated as guidelines, recommendations and training material partly developed with children in a citizen science approach. Such material will support the IAQ regulatory framework in schools, facilitate IAQ management, and broadly promote healthier indoors

Keywords: exposure iaq,ultrafine particles black carbon mitigation emerging pollutants exposome flame retardants microbiome bioaerosols respiratory infections epidemiology cognition schools
Active galactic nuclei and Population III stars in early galaxies (APEX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1582491.0
EU funding (EUR): 1582491.0
Participants: 1
Project status: SIGNED

The first stars must have started the generation of heavy elements and the formation of the first galaxies in the earliest phases of the Universe. At the same epoch, the seeds of the supermassive black holes which are detected in the centres of all nearby massive galaxies, including our own Milky Way, must have formed. While theoretically predicted, the detection of these first stars and seed black holes is an outstanding observational challenge in modern astronomy. With the proposed APEX project, I will capitalise on two game-changing capabilities of the James Webb Space Telescope (JWST) to deliver upon this challenge: (i) the coverage of previously inaccessible wavelengths, and (ii) the power to spectrally and spatially resolve early galaxies and, crucially, their surroundings with the integral-field unit spectrograph NIRSpec. This is decisive to single out the locations of the first stars and black holes through their distinct spectral signatures. With guaranteed JWST observations and the largest approved open-time programme to map galaxy spectra during the first billion years of cosmic time, the APEX team will: 1) search for and characterise the very first stars (Population III) that illuminate the Universe; 2) identify early black holes and measure the masses of active galactic nuclei to constrain supermassive black hole growth; 3) derive the physical properties of the earliest galaxies and study the role of the first stars and black holes in their evolution; 4) accurately compare our data to simulations to significantly improve models of the early Universe. Building on these novel and cutting-edge data and my extensive expertise in integral-field observations, the APEX project comes at the right time to enable a major leap forward in our understanding of the early Universe.

Keywords: galaxy formation,galaxy evolution,active galactic nuclei,interstellar medium,galaxy kinematics
The gravitational S-matrix: from theory to experiment (GravitaS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1498875.0
EU funding (EUR): 1498875.0
Participants: 1
Project status: SIGNED

Recent insights into the gravitational S-matrix, which describes the scattering of gravitating particles, have lead to a breakthrough in the perturbative understanding of the two-body problem in General Relativity, with direct relevance to gravitational wave physics. Such advances have been enabled by the methods of scattering amplitudes and effective field theory, originally developed in the context of particle and collider physics. Despite recent progress, a formalism to extract the dynamics of inspiralling compact binaries from scattering amplitudes is still lacking, in order for the results of this program to be fully implemented in the analysis of gravitational wave data. Furthermore, the advent of space-based detectors will enable the observation of extreme-mass-ratio binary systems, and push gravitational wave astronomy into the strong-field regime not amenable to traditional perturbative methods. We propose to address these challenges by breaking new ground and extending the reach of the gravitational S-matrix program by integrating insights from gravitational self-force theory, which solves the dynamics order-by-order in the mass ratio of the binary. We focus on three objectives: 1. Use the scattering of gravitational waves off a compact objects to extract universal predictions and extend the methods of scattering amplitudes beyond the weak-field regime. 2. Develop a new approach to predicting the scattering dynamics of extreme-mass-ratio binaries leveraging recent advances in scattering amplitudes and self-force theory. 3. Design a framework to translate observables from the scattering of binaries to the bound dynamics relevant for experiment, utilizing insights from effective field theory. The successful completion of this program will fundamentally reshape our understanding of gravitational scattering and the dynamics of compact binary systems, and revolutionize our ability to make predictions for current and future gravitational wave observatories.

Keywords: scattering amplitudes,gravitational waves,effective field theory,gravitational self force,general relativity,collider physics,particle physics,cross sections,post newtonian theory,post minkowskian theory,black holes,neutron stars,compact objects,quantum field theory
Global Scale Quantum Networking: Accelerating the feasibility, scalability, and maturity of networked quantum technologies (GSQNET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 2
Project status: SIGNED

There is a concerted worldwide effort to develop near-term networked quantum technologies (NQTs) to enable improved performances in imaging, sensing, computing, and communications. Recent landmark results from China’s quantum satellite Micius have demonstrated key milestones to increase the span of NQTs. A succession of international initiatives has also been launched to develop quantum networking infrastructure, such as the European Quantum Communication Infrastructure initiative. However, developing quantum networks (QNs) still has to overcome open challenges in feasibility, scalability, and maturity. This research project aims to directly address these open challenges. I will improve security analyses and develop two novel quantum key distribution protocols with improved loss tolerance and enhanced integration between terrestrial and satellite networks. This will enable longer-range quantum communications than existing methods. Numerical simulations and experimental demonstrations will be performed to validate this advantage. I will then develop an open-source numerical framework, based on a conceptually simple bi-graph, to inform on QN topologies that optimise entanglement distribution rates. This framework goes beyond specific network topologies considered in existing research and can be applied to any communication protocol. As a forward-looking application, I will explore the performance of distributed quantum computing. By developing insights into the optimal design of QNs that enhance the fidelity of non-local quantum gates, this work would help identify parameter regimes for quantum devices to support the operation of large-scale quantum computing. I will present a roadmap toward implementation, which may aid ongoing experimental and engineering efforts to advance NQTs. The GSQNET project is therefore a timely project that will support the development of NQTs in Europe through fundamental research and translational studies.

Keywords: quantum internet,quantum networks,distributed quantum technologies,entanglement distribution,quantum key distribution,security analyses
Accelerating bioactive oxygenated plant metabolites for innovative nutraceutical and health solutions (deCYPher hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Belgium,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 30.0
Total project cost (EUR): 341387.5
EU funding (EUR): 341387.5
Participants: 2
Project status: CLOSED

The deCYPher HOP-ON project aims to enhance the objectives of the deCYPher initiative by integrating new research methodologies and partnerships to accelerate the application and commercialization of bioactive plant secondary metabolites produced by microbes. The inclusion of Universidade NOVA de Lisboa (UNL, Portugal), strengthens deCYPher's interdisciplinary approach, incorporating advanced bioactivity assessments alongside synthetic biology (SynBio) and artificial intelligence (AI) tools. This new partner will focus on understanding the bioactivity of oxygenated plant metabolites and their metabolic interactions with gut microbiota, exploring applications in both food and non-food sectors. By studying the oxygenation patterns of flavonoids and terpenoids, deCYPher HOP-ON aims to uncover their impact on bioavailability, microbial metabolism, and therapeutic potential. Key objectives include evaluating the nutritional relevance of oxygenated metabolites, assessing their anti-inflammatory properties, and exploring non-food applications like skin anti-aging and antioxidant products. By demonstrating the health benefits and societal impact of these compounds, deCYPher HOP-ON will open new research directions and increase the translatability of microbial products, attracting stakeholders from industries such as pharmaceuticals, nutraceuticals, agriculture, and biotechnology. Additionally, it supports biodiversity by reducing pressure on wild plant populations and contributing to sustainability. In addition, the market potential of these SynBio-derived health products is significant, with opportunities for economic growth, new business ventures, and job creation in the rapidly expanding (bio)pharmaceuticals, phytonutrients, and nutraceuticals markets. Ultimately, deCYPher HOP-ON aims to deliver market-ready products with verified health benefits, ensuring a positive societal and economic impact, while advancing public health and fostering sustainable growth.

Keywords: bioactivities,structure function relationship,nutraceuticals,pharmacology perspective