Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Demonstration of an Innovative concept for high quality Transport of Perishable Agro Food Liquids inducing a Modal shift to Short Sea and River transport (Agro Highway)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Netherlands,Netherlands
Call: Small business innovation research for Transport (H2020-SMEINST-2-2015, 2015)
Start date: 2015-09-01
End date: 2018-02-28
Duration (months): 30.0
Total project cost (EUR): 4066715.0
EU funding (EUR): 2499950.0
Participants: 2
Project status: CLOSED

The Agro Highway provides a new, innovative mode of transport for perishable food liquids that will enable a disruptive breakthrough for transport and agriculture. The Agro Highway will develop, demonstrate and validate an aseptic, temperature controlled, quality monitoring, self-loading cargo system that will stimulate a shift in transport from road to water. The Agro Highway consortium aims to: • provide a flexible, maritime transport solution for perishable agro food liquids; • reduce costs for transport over middle to long distances; • increase the maximum transport distance and capacity. This is especially important for milk, the most important EU agro product. Increase of the maximum transport distance, will allow producers to reach new markets upon release of the milk quota; • optimize the supply chains, by reducing the necessity of pre- and post-processing and eliminating packaging waste while improving product quality and reducing their environmental impact. Together, this will result in a higher market value of the transported goods and completely new market opportunities for the EU transport and agricultural sector. The project will: • offer growth opportunities and new business opportunities for both SMEs directly involved in the project and connected third parties (mostly SMEs) that provide materials and services, increasing their profitability; in 2026 over € 100 mln/year of turnover will be created for the participants and their subcontractors; • accelerate market uptake and investments by the direct involvement of end users, financers and investors, lining up all the key players necessary for upscaling and commercializing the Agro Highway; • create new and improved business opportunities and open up new markets for the transport and agro sector, improving the EU’s market position and potential; • result in over 1.400 new jobs by 2026 with the participants and their subcontractors.

Keywords: perishable agro food liquids,maritime bulk transport,quality controled transport environment,milk
Programmable nucleic acid toolkits for cell-free diagnostics and genetically encoded biosensing (PRO-TOOLKITS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-10-01
End date: 2025-09-30
Duration (months): 72.0
Total project cost (EUR): 1999375.0
EU funding (EUR): 1999375.0
Participants: 1
Project status: SIGNED

WHY: The biological complexity of tumours and the large diversity of diagnostic biomarkers call for the development of innovative analytical tools that can detect multiple targets in a sensitive, specific and low-cost way and allow real-time monitoring of disease pathways and therapeutic effects. To provide such transformative tools creative thinking, innovative approach and the exploration of new research avenues that span different disciplines is necessary. WHAT: The goal of the PRO-TOOLKITS project is to address this need by developing innovative cell-free point of care diagnostic kits and genetically encodable biosensing tools. HOW: I oriented my independent career as a P.I. towards the design and development of synthetic nucleic acid-based nanodevices and nanomachines. With the help of an ERC Starting Grant I made ground-breaking contributions in the field of nucleic acid Nanotechnology. Motivated by these advancements I propose to challenge my know-how and expertise to explore new research avenues that will open exciting possibilities in biosensing applications. The key, ground-breaking IDEA underlying this project is to take advantage of my expertise and harness the advantageous features of RNA synthetic modules that can translate the expression of proteins in controlled in-vitro cell-free systems and can be also genetically encoded in living organisms and function inside the cells. I will develop rationally designed programmable nucleic acid modules that respond to a wide range of molecular markers and environmental stimuli through innovative nature-inspired mechanisms and that can be orthogonally wired to provide cell-free diagnostic kits and genetically encoded live-cell biosensing tools. The project will provide transformative approaches, methods and tools that will represent a genuine break-through in the fields of in-vitro diagnostics, biosensing and synthetic biology.

Keywords: biosensors,dna nanotechnology,aptamers,cell free systems,synthetic biology,nanobiotechnology
Nitrogen-Radical-Based Radical Strain-Release Strategies for the Divergent Assembly of Polyfunctionalized 3D-Building Blocks (N-STRAINED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Nitrogen-containing compounds underpin every aspect of our life: they form the structural basis of almost all drugs, agrochemicals and materials. The invention of methods to form C–N bonds is of strategic importance to discover and evolve molecules with direct implications on our lives. Central to this quest is designing synthetic strategies able to explore novel areas of chemical space. As the pharmaceutical sector is now aware of the greater clinical success of molecules with 3D architectures, developing methods able to assemble 3D-shaped and saturated building blocks is a topic of continuous scientific endeavour. The small and strained bicyclo[1.1.1]pentyl motif has been identified as a valuable bioisoter to replace flat (2D) aromatics and improve the potency of lead molecules. However, difficulties in preparing and modifying this structural element have severely limited its use in medicinal chemistry. There is an urgent need to develop novel methods that can effectively manipulate and introduce this motif into organic compounds. This project seeks to substantially expand the fields of photocatalysis and nitrogen-radicals by introducing the concept of “photoredox strain-release”: a novel reactivity that explores the ability of nitrogen-radicals to react with strained hydrocarbons (eg propellane) and enable a unique preparation of polyfunctionalized bicyclo[1.1.1]pentylamines. This research capitalizes on recent developments of the host group that has disclosed 2 novel ways to effectively generate nitrogen radicals. This reactivity will be integrated with other reaction platform allowing the divergent 1-step construction of many important nitrogenated 3D-building blocks that cannot be prepared by any other method. The development of such an innovative and ambitious project at the University of Manchester will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the training plan envisioned.

Keywords: nitrogen radical,photoredox catalysis,single electron transfer,bioisoster preparation,cascade reaction
Photonic Quantum Computing (PQC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 2009429.0
EU funding (EUR): 2009429.0
Participants: 1
Project status: CLOSED

This CoG will simultaneously address the outstanding research challenges to establishing the feasibility of large-scale photonic quantum computing by: 1. designing, fabricating and optimising the required hardware (WP1) components—inc. waveguides, couplers, phase shifters, delays, interconnects, spectral filters, photon sources and detectors, and control electronics 2. establishing paths to the integration (WP2) of these components into complete systems 3. developing accurate, exhaustive and verified model of errors (WP3) in photonic quantum systems for optimised fault tolerance strategies, and efficient large-scale architectures (WP4) 4. exploring and developing approaches to optimising this architecture both generally, and for specific applications (WP5) Addressing these challenges in parallel will be essential to realising the vision because interim outputs are required to address each challenge, and an iterative approach with the flexibility to redistribute resources and effort is necessary to reach an optimal solution in minimal time.

Keywords: quantum computing,quantum photonics,quantum engineering,quantum information processing
Autonomous Cellular Computers for Diagnosis (COMPUCELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2021-10-31
Duration (months): 78.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Early diagnostics based on multiple biomarkers is key in numerous diseases, yet current technologies for multiplexed detection are complicated and expensive. Living cells detect and process various environmental signals in parallel and can self-replicate, presenting an attractive platform for scalable and affordable autonomous diagnostic devices. In this project, I will apply my expertise in synthetic biology, the rational engineering of biological systems, to build cell-based biosensors for multiplexed diagnosis using the non-pathogenic bacterium Bacillus subtilis. In a first research line, I will conceive a scalable detection machinery by engineering chimeric receptors detecting extracellular biomarkers via sensing domains derived from antibodies. In a second research line, I will implement bio-molecular computing systems operating within and across bacterial cells to perform multiplexed biomarkers analysis. I will deploy in B. subtilis biomolecular logic gates and will engineer specific cell-cell communication systems to perform distributed multicellular computation in a bacterial consortia. My project is highly interdisciplinary and is at the cross-roads of genetic engineering, structural biology, biophysics, modeling, and clinics. On foundational point of view, I will make several breakthrough contributions to synthetic biology: (i) Advancing engineering frameworks for the Gram-positive model, B. subtilis. (ii) Pushing the limits of custom-ligand detection by engineered cells (iii) Exploring the frontiers of man-made biological computers. On an applied point of view, I plan to deliver a first prototype for the urinary diagnostic of diabetic nephropathy, a major complication of diabetes. Because of the modular design principles applied, my sensing platform will be reusable to diagnose other pathologies as well as for applications requiring custom-detection and bio-molecular computation like targeted therapy, drug delivery, or environmental monitoring.

Keywords: synthetic receptors,biomolecular computation,cellular computers,biological metrology,standardization,biomarkers,diabetic nehropathy
In-Situ Polyurethane Resins (INSPUR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy,Belgium
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2015, 2015)
Start date: 2016-03-01
End date: 2017-08-31
Duration (months): 18.0
Total project cost (EUR): 1797351.25
EU funding (EUR): 1258145.88
Participants: 2
Project status: CLOSED

Objective of the INSPUR project is to bring to the market a fully sustainable and solvent-less manufacturing process for the polyurethane direct and transfer coating of fabrics, knits, nonwovens or other substrates. INSPUR technology is based on an innovative bi-component resin formulation, which permits to avoid the use of solvents, or other toxic compounds, further improving the flexibility and reducing of 30% the energy consumption of coating manufacturing processes. INSPUR made products show remarkable improvement in terms of resistance, durability, mechanical performances, washing resistance allowing their utilization for high-end sports and technical applications, fashions and upholsteries. The Belgium Company VETEX, specialized in the manufacturing of high performances technical textiles, will provide the necessary case studies to validate the INSPUR technology in a real manufacturing environment by assessing the most suitable process migration strategies, the industrial performances and the technical capabilities of INSPUR. VETEX will further issue an earlier-adopter business case to evaluate the market uptake potential and to collect user feedbacks for INSPUR market validation. The overall European Technical textile sector will benefit by the completion of the project and by its large-scale uptake reducing the dependence from third countries, and avoiding the utilization of toxic chemicals for large consumer products.

Keywords: coating,textiles,polyurethanes,resins,sustainability,environment,fabrics,materials,solventfree
A joint doctoral program to educate tomorrow’s insect pathologists: Solving disease problems in the upcoming insect rearing industry. (INSECT DOCTORS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Germany,France,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-04-30
Duration (months): 54.0
Total project cost (EUR): 4201844.76
EU funding (EUR): 4201844.76
Participants: 9
Project status: SIGNED

Mass rearing of insects is a rapidly expanding industry due to improved mechanisation and increasing interest in the use of insects for a variety of purposes, such as sterile insect techniques, food and feed, waste management, and biocontrol of insect pest species. However, expertise is urgently needed to address emerging problems with infectious disease outbreaks in mass reared insects. Therefore, we propose the INSECT DOCTORS joint doctoral programme to build a durable European framework to educate experts in insect pathology in order to overcome the shortage in properly educated experts in Europe, and beyond. The research of INSECT DOCTORS will expand our understanding of emerging pathogens and will provide necessary tools for disease management in industrial insect rearing. The complementary expertise of the participating institutes and companies leads to an ambitious and exciting programme, providing interdisciplinary training and research in pertinent areas of insect pathology (bacteriology, mycology, virology) and entomology (immunology, physiology). In an overarching training program, novel advanced courses will provide students with technical, scientific and transferable skills. This interdisciplinary approach, crucial to provide insight in the complexity of insect-microbe interactions in a range of farmed insects, can only be achieved by joining forces between European universities. Furthermore, this joint doctoral programme aims to build durable partnerships for doctoral training in insect pathology, thereby overcoming national and interdisciplinary boundaries in doctoral research. By requiring equal excellence from all participants in this training programme we will contribute to high level PhD education across Europe. In short: INSECT DOCTORS will provide the durable framework, the people, the scientific knowledge and the tools to assist the upcoming insect industry to diagnose and mitigate infectious diseases in their mass reared insects cultures.

Keywords: entomology,pathology,insects,virology,fungi,bacteriology,microbiome,virus discovery
WEEK OF INNOVATIVE REGIONS IN EUROPE 2020 : The future of resilient regions in the new ERA (WIRE 2020)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Croatia
Call: WIRE XI Conference (H2020-IBA-SEWP-WIRE-11-2020, 2020)
Start date: 2019-12-02
End date: 2021-12-01
Duration (months): 24.0
Total project cost (EUR): 250000.0
EU funding (EUR): 250000.0
Participants: 1
Project status: CLOSED

A three-day online conference (WIRE XI or WIRE 2020) will be organized by the Faculty of economics, business and tourism, University of Split (FEBT) for the eleventh edition of the Week of Innovative Regions in Europe (WIRE XI or WIRE 2020). The conference will be held from 4 to 6 November 2020 as a part of the Croatian Presidency of the Council of the European Union. The event will gather key stakeholders with the aim to provoke and stimulate place-sensitive and mission-oriented governance of research and innovation for resilient regional development and understand its societal impact using synergies between different EU policies to support economic, social and territorial cohesion. In addition, the conference is to enable deeper understanding of challenges for different level governance within the new programming period, especially for remote regions keeping in mind not only relevant heritage but also brain circulation possibilities and needs. Representatives of European institutions, research organisations, clusters, education organisations, start-ups, SMEs, authorities and NGOs will be key actors and guarantee for the future cooperation and sharing of knowledge, delivering ways of a better understanding of R&I in the context of our immediate challenges

Keywords: place sensitive governance,open,resilient,heritage
Galileo-assisted robot to tackle the weed Rumex obtusifolius and increase the profitability and sustainability of dairy farming (GALIRUMI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,France,Netherlands,Netherlands,Netherlands,Denmark
Call: EGNSS applications fostering societal resilience and protecting the environment (H2020-SPACE-EGNSS-2019, 2019)
Start date: 2019-12-01
End date: 2023-09-30
Duration (months): 46.0
Total project cost (EUR): 1473817.5
EU funding (EUR): 1224742.5
Participants: 7
Project status: SIGNED

Agriculture provides humans with necessary food and raw materials, but its environmental impact is unacceptably high. Much effort is underway to make agriculture more sustainable, for example through precision agriculture or organic agriculture. In all of agriculture, controlling weeds is a major issue. Weed control with herbicides leads to a large environmental impact. Manual weed control leads to back-breaking labour, high labour costs, and difficulties of finding sufficient labour. The main objective of GALIRUMI is to deliver robot weeding for herbicide-free weed control in dairy farming. Robotic weeding will reduce the environmental impact of dairy farming by eliminating herbicide use and reducing exposure of farm workers to herbicides. It will also remove an important obstacle for dairy farmers to switch to organic production, thereby contributing to an increase in production of organically produced milk and higher incomes for farmers. GALIRUMI will develop and demonstrate a number of innovative technologies in weed detection, weed degradation, autonomous vehicles and robot-as-a-service for precision dairy farming based on precise navigation provided by EGNSS. Several areas of expertise are needed for successful development of practical robotic weeding: • EGNSS • Computer vision for weed detection • Construction of farm machinery • Providing services to farmers • Weed science • Dairy research The robotic weeding control system is the end product that GALIRUMI is aiming to put into practice and commercialise, proposed by dock weeding as a service either by: • Laser defoliation system using small robot that requires frequent application in the field. • Medium sized robot system with an electrocution tool that requires single season application in the field. GALIRUMI will significantly reduce manual labour for weeding, weed management cost, damage to grassland from the application of herbicide, impact of dairy farming on the environment and dairy cow discomfort

Keywords: galileo,precision agriculture,robotic,autonomous navigation,weeding,visual detection,dairy farming,altboc,broad leaved dock,electrocution weeding,laser weeding