Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Establishing Lensed Supernovae as Probes to Address the Hubble Tension (PHOLOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Lensed supernovae offer promising tools for cosmology with the upcoming revolutionary LSST survey, however the current techniques to both find these systems and to properly use them to infer the Hubble constant (H0) are severely underdeveloped. In this fellowship, I propose PHOLOS (Probing H0 with Lensing Of Supernovae), a three-part project to make lasting contributions to all steps of this process. I will first solve the longstanding problem of finding and prioritising lensed supernovae, by simultaneous exploitation of multiple datasets to find lensed supernova canidates without spectroscopic follow-up. I will then address the issue of the mass distribution of lensing galaxies (a recent systematic worry in all time-delay cosmography studies), by modelling population level characteristics of a large sample of lensed quasars. Finally I will combine the new lensed supernovae and mass model constraints in a cosmological inference pipeline that will scale to the hundreds of systems with heterogeneous data quality expected from LSST, yielding a precise and accurate measurement of H0. The timing of this project is ideal as LSST will start collecting data in mid-2023. By expanding my knowledge and (transferable) skills, this project will prepare me to be world-leading researcher thanks to new expertise on specific datasets like LSST and Gaia, on analysis techniques and machine learning methods, and on astrophysical phenomena like supernovae, gravitational lensing, and galaxy mass profiles.

Keywords: observational astronomy
Blocking BAFF signaling to treat Proliferative Kidney Disease (PKD) in trout (PKDcontrol)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain,Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-12-01
End date: 2024-05-31
Duration (months): 18.0
Total project cost (EUR): 156428.57
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

PKDControl is aimed at validating the use of a recombinant protein to reduce the pathology and mortality produced by proliferative kidney disease (PKD) in salmonids. PKD is caused by the myxozoan parasite Tetracapsuloides bryosalmonae that affects both cultured and wild salmonids in North America and Europe. It can eventually lead to mortalities of up to 90%, generating great economic loses every year to the aquaculture industry. This problem may be aggravated by global warming since the incidence and severity of PKD are exacerbated by rising temperatures. During my ERC Consolidator Grant we have demonstrated that the cytokine BAFF (B cell activating factor) mediates the dysregulation of diverse B cell subsets present in the kidney during PKD. We have shown that the intramuscular injection of a plasmid coding for the extracellular domain of BAFF receptor (BAFF-R) led to secretion of this truncated BAFF-R (tBAFF-R) that, in turn sequestered circulating BAFF, blocking BAFF signalling. Preliminary field tests in Spain and USA demonstrated the potential of this approach in reducing the pathology and mortality of the infected stocks. In this project, we will recombinantly produce tBAFF-R in yeast to facilitate its uptake by the industry and test its bioactivity in both lab and field experiments. In parallel to these technical activities, we will reinforce the IPR position (based on a PCT - “international” - patent application that has received a very positive patentability report by the patent office). We will also design a long-term IPR strategy and develop a knowledge transfer strategy through the recently initiated collaboration with a fish health management company, willing to reach commercialization of tBAFF-R under a license and to contribute with their own funds to the activities carried out under this project. A business case will also be elaborated to support the commercialization of the recombinant tBAFF-R to ensure that the innovation potential of our results.
Quantum Microwave Detection with Diamond Spins (QuMicro)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium,France,Hungary,Germany,Austria
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-04-01
End date: 2025-09-30
Duration (months): 42.0
Total project cost (EUR): 2914056.0
EU funding (EUR): 2914056.0
Participants: 6
Project status: SIGNED

Microwave detection is one of the most widely spread technologies in our society, spanning across areas as diverse as telecommunications, computers, radio-astronomy, navigation and air traffic control, spectroscopy, and medical diagnostics. In this proposal we address emerging and advanced MW applications that start from the same basis – a need for ultrasensitive detection with a high spectral resolution, and, in addition, requesting portable integrated instruments. Emerging quantum technology devices acting as sensors can lead to a major breakthrough in the application field through high sensitivity and frequency resolution. In QuMicro, we propose to develop a quantum technology for the next generation of microwave detection devices, surpassing the capabilities of all currently available methods .The devices will enable the rapid measurement of the frequency, amplitude, and phase of microwave fields. We will achieve extremely fast (nanosecond-scale) transient detection, a broad detection range spanning tens of gigahertz, and parts-per-million frequency resolution with ultrahigh sensitivity. The QuMicro system is based on a novel detection scheme and on the pioneering innovation concept of photoelectrically detected magnetic resonance with nitrogen-vacancy colour centre qubits in diamond, as a highly performant platform for microwave signal detection at room temperature. We will start our developments from a theoretical framework for quantum microwave sensing protocols and devices, and leveraging schemes based on many-body quantum correlations, implemented in QuMicro engineered devices.To achieve these goals, QuMicro will connect with scientists and engineers across a broad range of topics. The photoelectrical readout guarantees compatibility with scalable semiconductor electronics, providing a direct outlook towards commercial applications and a science-to-technology leap for microwave sensors with unrivalled performance.

Keywords: quantum sensing and metrology diamond quantum devices
The Word and the Brain: Rhetoric and Persuasion in Soul and Body (NEUROWORD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

The power of words is not a metaphor. The word-and-brain entwinement, part of the mind-and-body relationship, has long been the focus of religious, philosophical, and scientific debates, e.g., on the nature of prayer and meditation. Modern-day psychology and neuroscience are also fascinated by how verbal suggestion affects neuroplasticity and healing. NEUROWORD will present an interdisciplinary and comprehensive historical study of reflections on the impact of eloquent speech on the human body. In the early modern critical scientific context, when the seat of consciousness was transferred from the soul to the brain, I will examine the full spectrum of views on the relationship between the word and the brain across the disciplines concerned with experiences of soul, mind, and body: rhetoric, musicology, preaching, theological anthropology, philosophy, medical psychology, logopedics, and neurophysiology. I will examine not how rhetoric was used in scientific discourse but how it was deemed able to affect the brain. The psycho- and neurophysiology of persuasion can be best explored through the lens of rhetoric, as it was less prone to the mind-body dualism professed by much of the natural philosophy. These matters have not been studied, but by filling this gap, we can gain valuable insights into the entangled history of conceptualization of the mind-and-body relationship. This project is critical at a time when our mediated environments make rhetoric ambiguous with respect to truth and ethics, which demands a historical perspective on the neuroscience of eloquence for an educated approach to scientific communication. At the Warburg Institute, a leading centre for the history of rhetoric and part of the University of London with its range of prominent neuroscience programs, I will be a member of a stimulating interdisciplinary community and will do ground-breaking research in the history of scientific communication.

Keywords: rhetoric,eloquence,persuasion,soul,body,brain,nerves,animal spirits,humours,emotions,passions religious anthropology,natural philosophy,psychology,neuroanatomy,neurophysiology
Detection and characterization of cyclic di-GMP-binding proteins (cdiGMPBP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

Nucleotide signaling plays an important role in the adjustment of microbial physiology and metabolism. These signaling systems are involved in the regulation of all physiological processes including biofilm formation, virulence, environmental survival, and phage defense. One of the most prominent nucleotide-based second messenger molecules is the ubiquitous second messenger cyclic di-GMP. Cyclic di‐GMP synthesizing and hydrolyzing proteins, GGDEF and EAL domain proteins, respectively, are widely present across bacterial phyla, numerous within genomes, and highly conserved throughout the phylogenetic tree. However, there is still limited understanding of c-di-GMP binding receptors, since they are diverse, not necessarily characterized by common signature binding motifs, and still require experimentation to be identified. Having established a novel screen for cyclic di-GMP binding proteins based on alterations in thermal stability (PISA), this project aims to identify and characterize novel c-di-GMP binding receptors of the gastrointestinal pathogen Salmonella typhimurium as a model organism. Candidate c-di-GMP binding proteins will be verified by alternative approaches. Verified receptors will be assessed using microbiology, biochemistry, molecular biology, bioinformatics, and genetic engineering approaches. While new cyclic di-GMP binding proteins will be predominantly characterized in Salmonella typhimurium, novel and improved screens for cyclic di-GMP binding proteins based on mass-spectrometry-based DRaCALA and isolation of cellular nanomachines like ribosomes will be developed and partially investigated as research resources. Successful conduction of this post-doctoral project will expand the number of c-di-GMP receptors, discover novel underlying mechanisms of regulation by c-di-GMP, and thus significantly improve our understanding of the multilayer regulation of microbial pathways that contribute to the exceptional adaptation and evolution of bacteria.

Keywords: cyclic di gmp,c di gmp binding proteins,receptors,salmonella typhimurium,mass spectrometry,bacterial physiology,biofilm formation
Enhancing Scientific Capacity for Energy Poverty (ENPOWER)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Bosnia and Herzegovina,Ireland,Italy,Belgium,Netherlands
Call: Twinning Green Deal (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1567743.34
EU funding (EUR): 1498443.34
Participants: 5
Project status: SIGNED

Today over 41 million EU citizens are unable to access essential energy services and suffered from energy poverty. This led the European Commission (EC) to consider energy poverty a major societal challenge. In Bosnia and Herzegovina around 70-15% of households are found to be energy poor. It is well recognized that solving of energy poverty problem can have multiple benefits on health, air quality, comfort, and well-being, and improved household budgets, boosting economic growth and prosperity in the region. Solutions for energy poverty are related to the search for energy efficiency, which calls for long-term sector specific interventions, focusing on several causes of energy vulnerability and affecting other policy areas, such as energy justice, social, health, economy, CO2 emissions reductions, and other macroeconomic areas. Solving this problem in any country demands close cooperation among different sectors: research, technology, policy, law, innovation, sociology, and economy. That is why solutions for eliminating energy poverty require an innovative, interdisciplinary, and structural approach with strong cooperation across countries and across sectors. ENPOWER will lead the transformative change in Bosnia and Herzegovina (B&H) to strengthen the scientific reputation, attractiveness and networking channels of the University of Banja Luka (UNIBL) through supporting its innovation and research excellence in energy poverty and justice energy, sustainable buildings, energy efficiency, smart energy, human capital development, and application of innovative approaches, co-creative solution finding with business and policy makers, as well as in involvement of different ecosystems of innovation through the newly formed Building Advisory System Living Lab (BAS-Lab), which will be developed through cooperation with distinguished EU partners with established scientific excellence.

Keywords: sustainable development goals,energy poverty,energy justice,sustainable building,green energy solutions,ai,interdisciplinary research,transformative change,networking
Models of the maternal and fetal cardiovascular systems coupling via uterus and placenta (MEASURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: CLOSED

Complications occur in 5-10% of pregnancies, resulting every year in 2.6 million stillbirths and 303,000 maternal deaths. There is established evidence that complications and stillbirth are associated with abnormal development/adaptation of the cardiovascular system (CVS) during pregnancy. However, the literature lacks a holistic approach and only a few limited aspects have been investigated. Therefore, MEASURE aims at pursuing a holistic investigation of the CVS and the coupling between its subsystems (fetal and maternal CVS), mediated by the uterus and placenta. Synchronized Doppler and electrophysiological acquisitions will be performed to produce a unique dataset for the identification of a mathematical model describing the CVS. This will be achieved through robust and accurate extraction of time series representing the characteristics of the CVS in healthy pregnancies. Through an innovative aggregating strategy proposed to improve clinical reliability, the obtained model will be translated into a coupling map, i.e., a graphical representation of the relationships between the CVS subsystems and their variables. Being more intuitive and easier to interpret, this representation is particularly suitable for its clinical use and uptake. Finally, the comparison between the coupling maps of healthy and complicated pregnancies will allow identifying anomalies in the interactions between the CVS subsystems and designing/training a machine learning classifier to automatically discern between them. The outcomes of MEASURE will improve our understanding of the physiological mechanisms underlying pregnancy and original causes of complications, paving the way for the development of novel, powerful, diagnostic tools for timely diagnosis and, possibly, prediction of pregnancy complications. The support of academic, industrial, and clinical partners will provide all the instruments to achieve the envisioned scientific breakthroughs and favour their clinical translation.

Keywords: modeling cardiovascular system pregnancy monitoring perinatal medicine pregnancy complication model identification coupling analysis biomedical engineering
Formation and evolution of cyclic molecules in the interstellar medium (LIFECYCLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-16
End date: 2026-04-15
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

During the last years, we have witnessed an evermore increase in the number of molecules detected in the region between stars, the interstellar medium, where new stars are born. Of the different families of molecules to which the new astronomical detections belong, cyclic and aromatic molecules are particularly puzzling for astrochemistry. Although they are ubiquitous in Earth-based chemistry, the positive detection of aromatic species in the interstellar medium came only a few years ago. This finding has initiated a wave of detections that reveal as many answers as pose new vital questions. For example, aromatic species are critical in the formation of prebiotic molecules. Hence, detecting these molecules presents significant, far-reaching implications for questions beyond astronomy, such as the origin of life on our planet. In this project, we will determine the main formation routes of cyclic and aromatic molecules in the interstellar medium and the main destruction and conversion pathways that these molecules undertake once formed. We will pursue the project using first principles computer simulations, aiming to disentangle the physical and chemical basis for the origin of these species. Our goal is to find sources of molecular diversity in our universe, constrain the maximum chemical complexity expected in space for cyclic species, and determine how these molecules could be delivered to planets such as the Earth.
Challenging the state-of-the-art of low intensity noise, single frequency fiber lasers (KiLoS LASER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

The focus of this project is the development of state-of-the-art kW-class, low noise, single frequency (SF) fiber laser. SF lasers operate with a single longitudinal mode, emitting quasi-monochromatic light with kHz-class linewidth and low intensity noise. This class of lasers are in great demand for precision time/frequency metrology, atom cooling, coherent LIDAR, and laser spectroscopy. However, power scaling SF fiber lasers, while maintaining its low noise properties and high beam quality has been a challenge due to the onset of stimulated Brillouin scattering (SBS) and transverse modal instability (TMI) that disrupt the stable system operation beyond a certain power level (known as threshold). But high-power (> 500 W) low-intensity noise, SF lasers with high beam quality are quintessential for building next generation interferometric gravitational wave detectors (GWDs) and efficient neutral beam injector systems for fusion reactors. The current state-of-the-art for these systems is limited to ~ 400 W in an all-fiber architecture. We intend to challenge it by developing kW-class, low-noise SF fiber laser by using optimized laser design, novel ytterbium-doped fibers (commercial and customized) and efficient techniques to suppress the undesirable nonlinear and thermal effects. Such a system would also be valuable in understanding the dynamics and interplay between SBS and TMI and developing an accurate system model for optimized laser parameters and threshold levels. For this, we seek to combine the expertise of the applicant (Roopa Prakash), in building kW-class, narrow linewidth (~10 GHz), polarization-maintaining fiber lasers with the expertise of Giorgio Santarelli’s group in developing state-of-the-art low-intensity noise, SF lasers using specialty fibers. The interdisciplinary nature of this project will generate advances beyond the state-of-the-art not only in the fields involved in its development, but also in those where this laser can be applied.

Keywords: fiber lasers,high power,low noise,single frequency,special optical fibers,stimulated brillouin scattering sbs,transverse modal instability tmi,gravitational wave detectors