Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rapid Magnetic Blood Filtration for the Treatment of Sepsis: a Feasibility Study (NANOSEPSIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project will look at a novel method of treating sepsis, one of the world’s leading causes of death. The method uses magnetic nanoparticles (MNPs) that bind to specific entities in blood, combined with MediSieve's patented magnetic blood filter. By infusing the MNPs into an extra-corporeal blood loop containing the filter, MediSieve can remove both the pathogens that cause sepsis (bacteria) and the endotoxins that are responsible for the dysregulated immune response which is characteristic of sepsis. Importantly the method would work even in antibiotic resistant cases. Annually, there are 1M cases in the US and 900K in Europe, with 135K deaths/year in the EU. Mortality rates are 29-50% with a cost of €25K per patient. With the aging of global populations sepsis incidence is increasing rapidly (8-13% annually in the decade to 2013). The challenge is that both the pathogens and the immune response contribute to the disease. The destruction of bacteria by the immune system or antibiotics creates large quantities of endotoxins, which in turn aggravate the immune response and cause a cascade towards septic shock. MNPs that bind specifically to gram-negative bacteria and endotoxins enable the two targets to be rapidly and safely removed from circulation using MediSieve’s magnetic filter. The method provides the unique capability to specifically target both root causes of sepsis, reduce both the mortality and the economic costs of sepsis. The objectives of this Phase 1 study are to validate the technical and commercial feasibility of the proposed treatment method. The latter includes detailed market research, business planning, healthcare economics modelling and a detailed investment proposal with timelines and return on investment projections. The technical assessment will include in vitro lab studies validating that the MNPs efficiently bind to both targets and captured by the magnetic filter. A Phase 2 project would include pre-clinical and clinical studies.

Keywords: sepsis,magnetic nanoparticles,magnetic blood filtration,medical devices
Interactions between von Neumann algebras and quantum algebras (INNEQUAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

During his construction of a solid mathematical theory behind - the at that time completely new - quantum mechanics, von Neumann introduced his eponymous algebras to describe observable quantities. These “von Neumann algebras” became a basic tool in various other branches of mathematics, including Lie theory (the theory of continuous symmetries), non-commutative geometry (a “quantum” version of classical differential geometry), and, surprisingly, the theory of knots, for which V. Jones received a Fields Medal. Strangely enough, although the theory of von Neumann algebras is quite pervasive in mathematics and mathematical physics, their actual construction and classification remains largely shrouded in mystery (despite deep work on classification by A. Connes, also getting him a Fields Medal). Particularly unsatisfactory is that the types of von Neumann algebras that are most relevant to quantum mechanics, so-called “type III”-algebras, are very rare. With this Marie-Curie fellowship, I pick up the two challenges of construction and classification, especially focussing on Connes' famous rigidity conjecture for lattices in Lie groups as well as type III von Neumann algebras, using two entirely new approaches. The first is the use of finite-dimensional approximations, that I used previously in a different context (studying the Haagerup property and Lp-Fourier multipliers). The second new approach is based on the theory of quantum groups. Utrecht University (host institution) is the unique place in Europe housing both experts in non-commutative analysis and Lie theory, and thereby provides exactly the necessary (complementary) expertise that is necessary to attack these deep and profound problems. The results will have a lasting impact on and connect further the theories of non-commutative geometry, operator algebras, Lie theory, quantum group theory and partly quantum physics.

Keywords: quantum groups,von neumann algebras,operator spaces,approximation properties
Next-generation interdigitated back-contacted silicon heterojunction solar cells and modules by design and process innovations (NextBase)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Germany,Germany,Germany,Switzerland,Switzerland,Belgium,Norway,France,Czechia,Netherlands,Netherlands
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 4452850.0
EU funding (EUR): 3800421.25
Participants: 15
Project status: CLOSED

The NextBase project, involving 8 research institutions and 6 companies, deals with the development of innovative high-performance c-Si solar cells and modules based on the interdigitated back-contacted silicon heterojunction (IBC-SHJ) solar cell concept targeting cells with efficiency above 26.0% and corresponding solar modules with efficiency above 22.0%. In particular, a number of new design and process innovations throughout the wafer, cell and module fabrication that go beyond the state-of-the-art will be introduced into the device to achieve the targeted efficiency values. At the same time, the NextBase project pursues the development of a new industrial manufacturing tool and low-cost processes for the IBC-SHJ solar cells enabling a competitive IBC-SHJ solar module cost of < 0.35 €/Wp.

Keywords: c si photovoltaics
A Non-Enzymatic Gluconeogenesis and Fatty Acid Cycle (NonEnzymatic)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

All of life’s molecules, including genetic polymers, are built up and broken down by interwoven chemical processes collectively known as metabolism. But how did life’s chemical pathways emerge before there were genetically encoded enzymes to act as catalysts? Why does biochemistry use the reactions and pathways that it does and not others? One compelling answer to these questions is that precursors to core metabolic pathways emerged as the result of spontaneous chemical processes. Indeed, recent work from the supervisor’s lab and others has shown that much of life’s core metabolic chemistry, such as the Krebs cycle, can occur without enzymes, catalyzed by minerals and metals, to produce biochemistry’s universal building blocks. But how did these networks of pre-enzymatic chemical reactions branch out to become the biosynthetic pathways we know today? This project aims to understand the emergence of life’s anabolic pathways for the synthesis of sugars (gluconeogenesis) and fats (the fatty acid cycle), by chemically recreating them in the lab. To achieve these goals, special attention is paid to the pre-organizing and catalytic effect of mineral surfaces. The researcher will bring existing skills in homogeneous catalysis and organic chemistry, and gain new skills in analytical chemistry, heterogeneous catalysis and the chemistry of complex systems.

Keywords: metabolism,non enzymatic chemistry,sugars,prebiotic chemistry,minerals
The microbial degradation and utilization of mucin by Bacteroides in ulcerative colitis (MUC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2020-08-31
Duration (months): 36.0
Total project cost (EUR): 247059.0
EU funding (EUR): 247059.0
Participants: 2
Project status: CLOSED

The gastrointestinal tract is colonized by a community of microbes, the microbiota, which has a significant impact on human health and nutrition. The mucus gel layer structure provides the barrier between the microbiota and the intestine preventing the occurrence of the inflammation process. Indeed, an altered microbiota (towards mucus degrading bacteria) and defects in the mucus structure have been shown to be associated with inflammatory bowel diseases, such as ulcerative colitis. Understanding how members of the microbiota can alter mucin composition, can, potentially, be deployed to ensure that the structure of this ecosystem maximizes human health. This approach, however, is limited by a lack of understanding how mucins are metabolized by the microbiota. Significantly, available genomic/metagenomics sequence data of the microbiota presents an exciting, but so far, unfulfilled, opportunity to make decisive advances in our understanding of mucin degradation by members of this ecosystem. In this project I will seek to combine this genomic information with in vivo studies to understand the mechanisms of mucin utilization by the human microbiota and the impact on UC development. The data from the research programme will underpin the development of future therapeutic strategies to improve human health. The fellow is Portuguese and is now completing her PhD at the Newcastle University, UK. The fellow has experience in enzyme activity screening, enzymatic characterization and structural biology. In this fellowship she will have the opportunity to develop skills in genetic manipulation of anaerobic bacteria, microbiota in vivo (mouse) studies and structural analysis of O-glycans. This fellowship will enable the fellow develop her current skill set to include methodologies and approaches so that the molecular analysis of the target enzymes can be placed within a biological context.

Keywords: human microbiota,mucin,o glycan degradation,sulfatases,glycosidases,ulcerative colitis
Composite integrated photonic platform by femtosecond laser micromachining (CAPABLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy,Spain
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2022-12-31
Duration (months): 63.0
Total project cost (EUR): 2381875.0
EU funding (EUR): 1831875.0
Participants: 3
Project status: CLOSED

The quantum technology revolution promises a transformational impact on the society and economics worldwide. It will enable breakthrough advancements in such diverse fields as secure communications, computing, metrology, and imaging. Quantum photonics, which recently received an incredible boost by the use of integrated optical circuits, is an excellent technological platform to enable such revolution, as it already plays a relevant role in many of the above applications. However, some major technical roadblocks needs to be overcome. Currently, the various components required for a complete quantum photonic system are produced on very different materials by dedicated fabrication technologies, as no single material is able to fulfil all the requirements for single-photon generation, manipulation, storage and detection. This project proposes a new hybrid approach for integrated quantum photonic systems based on femtosecond laser microfabrication (FLM), enabling the innovative miniaturization of various components on different materials, but with a single tool and with very favourable integration capabilities. This project will mainly focus on two major breakthroughs: the first one will be increasing the complexity achievable in the photonic platform and demonstrating unprecedented quantum computation capability; the second one will be the integration in the platform of multiple single-photon quantum memories and their interconnection. Achievement of these goals will only be possible by taking full advantage of the unique features of FLM, from the possibility to machine very different materials, to the 3D capabilities in waveguide writing and selective material removal. The successful demonstration and functional validation of this hybrid, integrated photonic platform will represent a significant leap for photonic microsystems in quantum computing and quantum communications.

Keywords: femtosecond laser micromachining
Power to the People. Verified. (POWVER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 2425000.0
EU funding (EUR): 2425000.0
Participants: 1
Project status: CLOSED

Twenty years ago we were able to repair cars at home. Nowadays customer services repair coffee machines. By installing software updates. Soon you will no longer be able to repair your bike. Embedded software innovations boost our society; they help us tremendously in our daily life. But we do not understand what the software does, regardless of how well educated or smart we are. Proprietary embedded software has become an opaque layer between functionality and user. That layer is thick enough to possibly induce malicious or unintended behaviour. Proprietary embedded software locks us out of the products we own. We need a turn to open and hence customisable embedded software. However, a minor customisation might well have strong unexpected impact, for instance on the longevity of an embedded battery, or the safety of the battery charging process. We thus need means to detect, quantify and prevent such implications. The POWVER project lays the foundations. It provides quantitative verification technology for system-level correctness, safety, dependability, and performability. In this endeavour, POWVER takes up a hard scientific challenge, a challenge where discrete and continuous, real-time, stochastic as well as data- and user-dependent aspects are all deeply intertwined: embedded software for electric power management. Electric power is intricate to handle by software, is safety-critical, but vital for mobile devices and their longevity. Since ever more tools, gadgets, and vehicles run on batteries and use power harvesting, power management is a pivot of the future. POWVER will demonstrate that quantitative verification of open embedded software is feasible, and can ensure safe and dependable operation of safety-critical devices. A proof of concept will target the field of electric mobility, set up as a blueprint for other battery-powered appliances. As such, POWVER is the nucleus for a radical change in the way embedded software quality is assured in general.

Keywords: markov chain stochastic probabilistic systems model checking embedded automated verification energy concurrency theory abstraction refinement automata dependable performance temporal logic game time
Scaling-up Packages of Interventions for Cardiovascular disease prevention in selected sites in Europe and Sub-Saharan Africa: An implementation research (SPICES Project) (SPICES)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Uganda,South Africa,Belgium,France,United Kingdom,United Kingdom,United Kingdom
Call: Implementation research for scaling-up of evidence based innovations and good practice in Europe and low- and middle-income countries (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 5902038.75
EU funding (EUR): 5902038.75
Participants: 8
Project status: SIGNED

The overall research objective of the SPICES project is to implement and evaluate a comprehensive CVD prevention and control program in five settings: a rural & semi-urban community in a low-income country (Uganda), middle income (South Africa) and vulnerable groups in three high-income countries (Belgium, France and United Kingdom) as well as to identify and compare the barriers and facilitators across study contexts. The project will be evaluated using a mix of formative assessments; pre/post and trial designs. At the beginning of the project, we will conduct baseline assessments including literature reviews, formative studies, household surveys (where feasible) and learn lessons from other projects to understand healthcare and lifestyle practices, barriers, and facilitators. A cost-effectiveness and cost benefit analysis will be included. In addition, the teams will conduct site exchanges visits to learn from each other and organise policy dialogues to ensure sustainability and maximise impact of the interventions. The implementation outcomes—acceptability, adoption, appropriateness, feasibility, fidelity, implementation cost, coverage, and sustainability will be evaluated – in order to understand the factors affecting the implementation, the processes, and the accruing results. The intervention of the SPICES project will aim to: (1) improve patients ’risk profiles (LDL-cholesterol, blood pressure, HbA1c (among patients with diabetes), modify lifestyles (diet and exercise and smoking cessation) and achieve recommended cholesterol, blood pressure and glycaemic control targets; (2) increase proportion of patients receiving appropriate BP, cholesterol and diabetes medication; (3) and mitigate the number of people developing complications such a stroke and myocardial infarction.

Keywords: cardiovascular disease,health promotion,profiling,disease management
Gene-activated AntiMicrobial Biomaterials for Bone regeneration (GAMBBa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: CLOSED

Osteomyelitis, i.e. bone infection, combined with the alarming rise in antibiotic resistance globally, is currently regarded as the most devastating clinical complication when attempting to repair bone defects. This project tackles these major challenges of modern bone tissue engineering by developing a novel technology with dual osteogenic and antimicrobial action i.e. regenerative scaffolds that can eliminate bacterial infection while simultaneously providing a bioactive environment for bone growth. The specific goal of this research proposal is to develop and evaluate a new, innovative and effective treatment for osteomyelitis by combining non-antibiotic antimicrobial nanoparticles with gene-activated scaffolds for bone regeneration. Osteoconductive collagen-nanohydroxyapatite scaffolds with proven bone-healing potential will be functionalised for the sustained delivery of genetic cargoes to improve tissue repair, i.e. plasmid DNA (pBMP-2) and microRNA (antagomiR-133a), using novel technologies pioneered at Prof O’Brien’s Lab in the Royal College of Surgeons in Ireland. The project will also study the incorporation of metal-ions, an innovative alternative to traditional antibiotics, into scaffolds and bioglasses developed at Prof Boccaccini’s Lab at Friedrich-Alexander-Universität Erlangen-Nürnberg. Diligently supervised by Profs. O’Brien and Boccaccini, and guided by a Personal Career Development Plan, I will develop complementary skills in project management, entrepreneurship, commercialisation, leadership and profile enhancement. Acquiring advanced research competences and complementary skills will allow me to mature as an independent scientist, enhancing my professional visibility, capacity and competitiveness in the field of regenerative medicine. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own group focused on novel biomaterial research and development.

Keywords: bone infection,nanomedicine,antimicrobials,regenerative scaffolds