Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Embedding RRI in Western Balkan Countries: Enhancement of Self-Sustaining R&I Ecosystems (WBC-RRI.NET)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Albania,Albania,Austria,Bosnia and Herzegovina,North Macedonia,Serbia,Greece,France,Montenegro
Call: Supporting the development of territorial Responsible Research and Innovation (H2020-SwafS-2020-1, 2020)
Start date: 2021-03-01
End date: 2024-02-29
Duration (months): 36.0
Total project cost (EUR): 1999995.0
EU funding (EUR): 1999995.0
Participants: 13
Project status: SIGNED

Although Western Balkan countries (WBCs) have improved in terms of R&I performance, research and innovation efforts should be further enhanced for bridging the remaining ‘gap’ with the rest European regions. RRI principles can act as enablers for the sustainable development of the local R&I systems, enhancing the effectiveness of R&I strategies contributing to the advancement of Western Balkan socio-economic progress in a transparent, open, and inclusive way through active participation of all quadruple helix actors. WBC-RRI.NET aims to foster the application of RRI principles at the territorial level in five (5) Western Balkan -4 region-level and 1 country-level- R&I ecosystems and promote a multi-level steering R&I governance framework in the WBCs. RRI principles will act as enablers to the shared learning and diffusion of R&I governance innovations at territorial level, enhancing R&I planning, including S3 Strategies in the WBCs. The project’s approach evolving through an analytical, reflective and implementation thread, will operationally address the 5 WB territories (partners represent all parts of the quadruple helix) and subsequently influence the wider WB region, by activating the embedding of RRI into their R&I ecosystems. This will be realised by RRI activities throughout the entire project (horizontal aspect), raising an active dialogue in the wider WB region and fostering the comprehension of all RRI pillars under a holistic framework based on a ‘smart directionality’ approach, offering stakeholder engagement with a focus on citizen participation. Alongside, 5 RRI ‘anchor’ initiatives (vertical aspect), as interventions touching in-depth specific RRI keys, territorial features and scientific domains, will allow RRI principles to be rooted in the territorial ecosystems leading to concrete impact to R&I territorial policies and societal regional needs. Finally, impact evaluation and dissemination activities focus on the project’s long-term sustainability.

Keywords: societal challenges,smart specialization strategies,ethics,open science,gender
Do early stone tools indicate a hominin ability to accumulate culture? (STONECULT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-09-30
Duration (months): 66.0
Total project cost (EUR): 1499837.0
EU funding (EUR): 1499837.0
Participants: 1
Project status: CLOSED

Cultural – not genetic – adaptations have allowed humans to colonise the planet. While discovering the roots of human culture has been described as one of the 125 most pressing scientific questions of our time (Science, 2005), it remains unclear when such forms of culture first arose in our lineage. Previous research has argued that similar social learning mechanisms underlie modern human as well as early hominin technology. But the latter shows periods of stasis – suggesting the underlying mechanisms were different. A better model for early hominins might be living non-human great apes. Instead of copying the behaviour from others with high fidelity (as modern humans do), ape approaches seem to be based on socially mediated individual reinventions (latent solutions; Tennie et al. 2009). Unlike high fidelity copying, latent solutions do not lead to 'cumulative cultural change', in which technological changes accrue over generations. Latent solutions are thus a core candidate to account for early hominin stone tools because, among other things, they provide an explanation for their stasis. Using both a top-down and a bottom-up testing approach, STONECULT will experimentally test whether early stone tools are manifestations of cumulative culture – currently the null hypothesis in the field – or whether they are best accounted for with the latent solutions model. That is, STONECULT will evaluate whether early stone tools were more similar to modern ape or modern human technologies. The outcomes and conclusions of STONECULT will therefore inform several fields at once (e.g. anthropology, archaeology, comparative psychology, ethology and primatology). This proposal is the first to test the new latent solutions account of early stone tools. If its predictions are confirmed, then cumulative culture will have emerged millions of years later in our lineage than is currently assumed. STONECULT will radically transform our understanding of the evolution of human culture.

Keywords: cumulative culture,innovation,tool use,tool making,cultural transmission,imitation
SkyLight: Innovations in titanium investment casting of lightweight structural components for aero engines (SkyLight)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom
Call: Innovations in Titanium investment casting of lightweight structural components for aero engines (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-02-01
End date: 2020-01-31
Duration (months): 36.0
Total project cost (EUR): 801040.25
EU funding (EUR): 801040.25
Participants: 1
Project status: CLOSED

Project SkyLight is proposed by AMRC Castings (which evolved out of Castings Technology International). AMRC Castings, a department of the University of Sheffield (USFD), is part of the UK’s High Value Manufacturing Catapult. AMRC Castings’ mission is to develop and disseminate casting technology to the benefit of the cast metal and manufacturing sectors. Based on the Topic Description, and on AMRC Castings’ long experience of similar projects, we believe that project SkyLight would enable the investment casting process to deliver greater geometrical complexity, reduce defects by 50%, optimise stiffness, and deliver weight saving of 15% to 30% and cost saving of 30% compared to conventionally fabricated multi-piece assemblies, along with significant environmental benefits for both the manufacturing and the use phase of the component. AMRC Castings helped Sulzer to achieve an improvement in pump absorbed efficiency - saving 10% on the power demand. AMRC Castings’ Patternless® process helped Rolls-Royce reduce the time from CAD model to prototypes from 6 months to 6 weeks, and developed more accurate naval propellers for the VT Group that are seen as setting a new standard for others to follow. AMRC Castings’ MEGAshell® process enables ceramic moulds with dimensions of up to 2m3 to be manufactured so that heavy section valve castings weighing several tonnes can be manufactured 34% lighter than the sand cast equivalent and reducing machining costs by over 50%. This year, AMRC Castings is installing what is believed to be the largest furnace for casting titanium aerospace components in Western Europe - a 1000kg titanium melter - to complement its existing state-of-the-art casting facilities. AMRC Castings has participated in 21 EU-funded collaborative research projects including 8 projects as coordinator - including research projects such as FASTCAST and events to achieve the greater participation of the castings sector in EU-funded research programmes.

Keywords: titanium investment casting lightweight structural components aero engine engine aerospace alloys geometrical complexity
Visualizing aquifers: sustainable water use in the Atacama Desert and beyond (INVISIBLE WATERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Chile
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2019-06-30
Duration (months): 30.0
Total project cost (EUR): 190862.1
EU funding (EUR): 190862.1
Participants: 2
Project status: CLOSED

Billions of people rely for their everyday existence on aquifers. The invisibility of these waters, however, poses formidable challenges for those who rely on them: locating, measuring and controlling aquifers is complex and precarious, yet of utmost importance for human survival in many parts of the world. The overall aim of the proposed project is to explore the vital connections between humans and aquifers in everyday life. Building on trans-disciplinary studies that consider water as the contested nexus of social and political affairs, this project explores groundwater as both mediating and generating diverse ‘groundwater practices’: as an invisible resource, groundwater requires visualization; as an underground supply, it calls for innovative extractive techniques; as a finite good, groundwater needs to be regulated and controlled; and as a practical everyday resource, it sustains irrigation, sanitation, and human consumption. Through ethnographic fieldwork in Atacama Desert of Northern Chile, this project will develop an analytical framework to understand how social relations are affected by various groundwater practices. The proposed research will explore such practices with a focus on the effects that the visualization of aquifers has on socio-economic and eco-political inequalities. Through transdisciplinary training at the Universidad Católica del Norte, I will strengthen methodological skills to study the groundwater practices of indigenous communities, hydro-geologists and state administrators. I will transfer the acquired skills to the UNESCO-IHE Institute for Water Education, where I will strengthen understandings of the dynamics among groundwater practices, power, and culture, providing trans-disciplinary input for policymakers engaged in the design and realization of the Sustainable Development Goals. Findings will be disseminated among policymakers, academics, and broader audiences concerned with environmental sustainability.

Keywords: water studies,social relations,invisibility,aquifers,human practices,infrastructures,connections,ethnographic methods,actor network theory,political ecology,latin america,sustainability
Real-time Content Analysis and Processing (ReCAP) for Agile Media Production (ReCAP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Austria,Austria,United Kingdom
Call: Support technology transfer to the creative industries (H2020-ICT-2016-1, 2016)
Start date: 2016-12-01
End date: 2018-05-31
Duration (months): 18.0
Total project cost (EUR): 1306125.0
EU funding (EUR): 990037.5
Participants: 4
Project status: CLOSED

The media production industry is rapidly evolving and expanding globally, primarily driven by the explosion in mobile devices such as phones and tablets, the ubiquity of internet access and the subsequent demand to consume content anywhere, at any time and on any device. Modern media production workflows must thus be agile and support multiple heterogeneous sources and playout targets in a responsive and cost-effective way. This poses challenges for quality assurance and Media Asset Management (MAM) where access to rich metadata and data integrity are essential. Today, these challenges can only be addressed by enterprise and high-end solutions used by major public and private broadcast companies; solutions which are highly proprietary, extremely costly and complex to implement for the large number of small to medium sized creative companies, small broadcasters and corporate teams responsible for producing audiovisual content for broadcast, video on demand, web and mobile consumption. This proposal aims to take recent technology research results from automatic real-time content analysis and processing and bring-to-market an affordable, integrated, scalable, open commercial software solution. It will include the automated extraction of metadata (e.g., detection of logos, faces, temporal segmentation, visual similarity) for use in media asset management and the analysis of the visual quality of the content and automatic tools for reducing or repairing quality impairments. The algorithms will be implemented as modules that can be integrated into real-time analysis pipelines, as well as batch processing for non-real time workflows and can be deployed locally or scaled as cloud-based services.

Keywords: real time content analysis,video processing,media asset management,image recognition,enhanced metadata creation and analysis,software development
Transcription-replication conflicts in disease and development (ConflictResolution)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1497530.0
EU funding (EUR): 1497530.0
Participants: 1
Project status: SIGNED

Genetic and epigenetic instability contribute to cancers, aging, developmental disorders, and neurological diseases, so in-depth understanding how this instability arises is an important question affecting millions in Europe. Physical conflicts between the transcription and DNA replication machineries are a potent endogenous source of this instability. My preliminary data indicate that a single collision can trigger long-term epigenetic changes and affect the normal expression state of genes. I hypothesize that collisions can rewire gene expression networks and lead to cellular transformations relevant to disease and development. Unfortunately, this mechanism is largely understudied owing to the lack of suitable cellular systems to characterize collisions in molecular detail. My proposal will address this key gap in knowledge. I recently pioneered a unique human cell-based episomal system to analyse collisions in an inducible and localized fashion. Using this highly tractable system, we will molecularly characterize the (epi)genetic consequences and identify novel factors that prevent or resolve collisions (Aim 1). To address the relevance of collisions in disease, we will establish a novel proximity-labelling system (Split-APEX2) to map collision sites and identify their associated genetic and chromatin changes in a breast cancer cell model. This cutting-edge technology will decipher their role in pathological transformations observed in breast cancer genomes (Aim 2). To link collisions to developmental transformations, we will determine their potential to induce local epigenetic changes during zygotic genome activation in mouse embryonic cells. This approach can shift the paradigm how cells in development first start to differ from each other and reprogram their genome into different cell types (Aim 3). Uncovering the key principles of collisions may implement highly innovative approaches to avoid or establish cellular transformations in disease and development.

Keywords: transcription replication conflicts,genetic and epigenetic instability,proximity labelling,dna replication,transcription,breast cancer,development
The game changer drug to cure alcohol use disorders (StopAddict)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-10-01
End date: 2022-03-31
Duration (months): 30.0
Total project cost (EUR): 3859659.0
EU funding (EUR): 2402680.0
Participants: 1
Project status: CLOSED

Alcohol use disorders (AUD) is a disease characterised by uncontrolled alcohol consumption. 283 million persons worldwide suffer from alcohol mise use which cause more than 3 million dead and 132.6 million disability-adjusted life years. Alcoholism has also huge damaging effects on families, communities and the overall society. Current drug therapies against AUD are unsuccessful due to poor efficacy and strong side effects. That situation leads to low patient recovery and only 10% of AUD people seeking for treatment. In this context, Kinnov-Therapeutics has developed a new revolutionary first-in-class drug allowing patients to control their alcohol consumption. KT-110 drug will highly impact the European burden of AUD by decreasing alcohol consumption on AUD patients by 70% leading to triple the number of AUD people seeking for treatments and save more than 5 million lives per year and several billion of social cost expenses. The efficacy of KT-110 is related to its action on a newly discovered pathway highly implicated in alcohol addiction. This major understanding of AUD addiction mechanism was granted the European college of neuropsychopharmacology Neuropsychopharmacology Award in 2009. After 20 years of intensive research and pre-clinical development, KT-110 has been accepted by the french regulatory agency for its first-in man phase II clinical trial by the end of 2018. This will be the main achievement of SMEi2 project. Moreover, all necessary actions for successful commercialisation to pharma companies (licensing deals) as well as continuous and updated IP and FTO issues are planned to be implemented during the SMEi2. Through StopAddict project KT-110 will become the next leader of AUD treatments by generating €117m of cumulative revenues between 2025-2027. Our project will also allow to create more than 400 direct and indirect European jobs.

Keywords: alcohol use disorders,first in class drug,alcohol addiction,novel neural pathway,major public health issus,huge medical need
Bioactive Octopus peptides with potential for aquaculture (BIOPTAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Scientific community is increasingly paying attention to new efficient preventive and therapeutic approaches aimed to limit the spread of classical and emergent microbial infections in animal farming, namely aquaculture. To date, several synthetic antimicrobial agents have been used to control bacterial infections in shellfish and fish cultured worldwide. However, around 90% of the aquatic bacteria are resistant to at least one antibiotic which will represent a threat to human health in a near future. Marine species compose around half of the total global biodiversity and considering their special living environment (in close contact with microbes), composition and properties (e.g., antibacterial, antiviral, antitumoral), these organisms have gained substantial importance as a “gold mine” of new natural bioactive compounds such as antimicrobial peptides (AMPs) and toxins. Therefore, BIOPTAL “Bioactive Octopus peptides with potential to aquaculture” proposal will focus on high-throughput protein search from unparalleled and under-explored reservoirs of peptide diversity – cephalopods – and their putative targets, through a multidisciplinary research that contemplates in vivo experimental challenges as engines to assure a broad screening of natural compounds by accounting the fact that cephalopods evolve differently from almost every other organism. In fact, e.g., octopuses, routinely edit their RNA sequences to adapt to their environment. This means that some important peptides with antimicrobial or other relevant properties to several industries must only occur under particular conditions, that researchers do not assess without simulate that conditions at the lab. Thus, BIOPTAL will integrate challenges, in silico multi-omics analyses and in vitro tests in order to “biodiscovery” peptides as novel therapeutic solutions from common octopus (Octopus vulgaris) to fight the appearance and persistence of multidrug-resistant bacterial strains in the aquaculture sector.

Keywords: antibiotic resistant bacteria,cephalopods,octopus vulgaris,natural compounds,in vivo challenges,amps,toxins,proteogenomics,in vitro tests,aquaculture