Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanical Oocyte Measurement as a predictive biomarker for Assisted Reproductive Technologies (MOM-ART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-15
End date: 2027-07-14
Duration (months): 30.0
Total project cost (EUR): 234530.4
EU funding (EUR): 234530.4
Participants: 3
Project status: TERMINATED

Infertility is a major societal problem and one in six people must use assisted reproductive technologies (ART) to conceive. However, ART success rates remain low (ca. 20%), which represents a significant burden for the patients due to the heavy treatments and high risk of miscarriage. Recent studies have revealed that the mechanical properties of female gametes (oocytes) are tightly regulated and can change with advancing maternal age (AMA), leading to a higher risk of miscarriage or congenital diseases. Mechanical biomarkers have thus been proposed to score “high-quality” oocytes in ART. However, their use is hampered by (1) the lack of precise knowledge of mechanical phenotype(s) associated with AMA and oocyte quality, and (2) the absence of appropriate technology to measure oocyte mechanical properties in medical settings. In MOM-ART, I propose to develop a user-friendly and non-invasive approach for the mechanical phenotyping of oocytes based on an innovative miniaturized measurement system with computational analysis. I will characterize mechanical phenotypes associated with AMA and/or developmental defects in mouse models to establish the predictive value of mechanical biomarkers for oocyte quality. I will finally evaluate the proposed microfluidic approach in a reproductive medicine department, in the frame of a non-academic placement, and aim thereby to identify minimal requirements that my approach and device must meet to be applied for oocyte mechanical scoring in medical setting. This comprehensive and interdisciplinary project will bring significant technological, fundamental, and medical advances in oocyte mechanobiology, directly applicable to oocyte quality assessment and personalized diagnostics in ART. In MOM-ART, I will interact with experts in microfluidics, developmental biology, and human reproduction. Upon completion of the fellowship, I will have consolidated my interdisciplinary and intersectional profile, which is key for my future career.

Keywords: prediction of oocyte development potential,mechanobiology,cell mechanical phenotyping,diagnostic tools,lab on a chip technology,in vitro fertilization,advanced maternal age
OPEN MUSIC EUROPE (OPENMUSE) – AN OPEN, SCALABLE DATA-TO-POLICY PIPELINE FOR EUROPEAN MUSIC ECOSYSTEMS (OpenMusE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Germany,Finland,Netherlands,Austria,Italy,Slovakia,Sweden,Ukraine,Lithuania,Bulgaria,Hungary,Poland
Call: Towards a competitive, fair and sustainable European music ecosystem (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2973812.5
EU funding (EUR): 2973812.5
Participants: 16
Project status: SIGNED

OpenMusE brings together music industry stakeholders and researchers from 11 EU countries and Ukraine. Our consortium recognises that placing European music ecosystems on a more competitive, fair, and sustainable footing requires evidence-based policymaking, business planning, and accuracy. We provide the data needed for these actions. Using transparent methods and tools, OpenMusE maps the policy and data landscape; bridges data gaps; and empowers stakeholders and policymakers to take data-driven actions. Our project is grounded on principles of open policy analysis, open science, and open-source software development. We work with stakeholders to identify data gaps on the EU, national, and regional levels; co-create indicators and methods for bridging them; develop free software tools for data collection and analysis; and report not just our findings, but every step taken to reach them. This is the logic behind our Open Music Observatory (OMO), an open-source platform that provides 360-degree intelligence on the music industry by integrating numerous data sources. The OMO is highly automated, providing “living policy documents” that refresh when the backend datasets are updated: these datasets include official statistics on music goods and services; data on musical participation via pan-European surveys, rights-holder data voluntarily shared by industry partners, and streaming service data sampled using novel algorithms developed by our consortium. Using the OMO and our open-source software, music MSMEs without technical departments or expertise will be able to access and analyse open data; model volume and value, including of zero-price uses; create better business models; and generate corporate social responsibility and sustainability reports; all at a fraction of current costs. We validate these tools in four pilot studies that will bring concrete benefits to stakeholders within the project lifespan.

Keywords: economics data science computational social science musicology sociology law
How dividing cells adapt to karyotypic evolution (KAREVO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Portugal
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2955225.0
EU funding (EUR): 2955225.0
Participants: 1
Project status: SIGNED

Alterations in chromosome number and size are hallmarks of cancer, and yet they are also crucial for species evolution. Recent insight on chromosome structure and segregation, together with significant advances in genomic sequencing, established previously underappreciated parallels between the mechanisms of karyotypic evolution during speciation and cancer. Importantly, alterations in chromosome number and size pose significant challenges for the cell division machinery. However, how dividing cells adapt to cope with karyotypic alterations remains an outstanding fundamental question with strong clinical implications. To address this, we propose an innovative approach that integrates super-resolution microscopy, large-scale 3D cryo-electron tomography reconstructions, computational modelling and cell fusion experiments in Indian and Chinese muntjacs, two closely related deer species with identical genomes, but extremely divergent chromosome number (2n=6/7 vs. 2n=46, respectively) and size. We will focus on dissecting mechanistic aspects underlying mitotic spindle organization, chromosome dynamics, checkpoint control of mitotic progression and segregation fidelity in both muntjac species, with the goal of identifying genes differentially required for efficient mitosis in cells with karyotypic alterations. In parallel, we will exploit functional genomics in Cervidae, including telomere-to-telomere sequencing of Indian and Chinese muntjac genomes, to determine and manipulate the exact chromosome fusion sites between both species, while testing the novel hypothesis of a viral mechanism in the evolution of their karyotypes. Lastly, to test the limits of karyotypic evolution for chromosome segregation, we will engineer mammalian cells with only 1 or 2 chromosomes and investigate whether and how cell division tolerates this extreme genome reorganization. This pioneer work will unveil vital cell adaptive mechanisms to karyotypic evolution relevant for speciation and cancer.

Keywords: cell division mitosis karyotype diversity karyotype evolution aneuploidy cancer speciation genome organization chromosome segregation atypical model systems
Decoding communication between mobile genetic elements (TalkingPhages)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Israel,Spain,United Kingdom
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-03-01
End date: 2030-02-28
Duration (months): 72.0
Total project cost (EUR): 8535528.0
EU funding (EUR): 8535528.0
Participants: 3
Project status: SIGNED

Communication between organisms is one of the most sophisticated forms of social interactions. It has been recently discovered that bacterial viruses (phages) show multiple social attributes including the ability to communicate extracellularly with their progenies through a peptide-based system called arbitrium. This system is utilized by phages to guide life-cycle decisions, such as the transitions between their quiescence and virulence states. It has subsequently become clear that this system is not exclusive to phages but is also present in other mobile genetic elements (MGEs) and that its underlying design and function has diversified considerably. Despite the wide-ranging impact of these discoveries, the molecular basis of these new systems of communication, and their function in different MGEs, remain to be deciphered. More importantly, although it has been proposed that phages only communicate with their progeny, our preliminary results indicate that the arbitrium system can be used by phages and other elements to communicate with unrelated MGEs, sometimes present in different bacterial species. However, the prevalence and ecological role of this unprecedented inter-MGE communication is unclear. In the TalkingPhages project, we’ll explore all these questions and establish the molecular basis used by arbitrium systems to shape MGE diversity, interactions amongst MGEs and bacterial ecology and evolution. Our team combines expertise in MGEs and communication systems using tools from genetics (Penadés), biochemistry (Marina) and eco-evolutionary dynamics (Eldar). By exposing the multi-layered network of communications between MGEs, which is amenable for exploration on multiple levels of resolution, this project would set a milestone in understanding the complex eco-evolutionary dynamics of MGEs and the relevance of their sociality, with potential impact on our understanding of virulence and resistance in clinically and agriculturally important bacterial species.

Keywords: bacteria,phages,mobile genetic elements,quorum sensing,communication,evolution,ecology,molecular biology,bacillus,arbitrium,cooperation
Atomic Layer-coated Graphene Electrode-based Micro-flexible and Structural Supercapacitors (ARMS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Finland,Sweden,Spain,Denmark,Latvia,France
Call: 2D materials-based devices and systems for energy storage and/or harvesting (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-02, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 4498901.25
EU funding (EUR): 4498901.25
Participants: 11
Project status: SIGNED

The overall objective of the ARMS project (Atomic layer-coated gRaphene electrode-Based Micro-flexible and Structural supercapacitors (ARMS) is to integrate comprehensive materials and processes, including graphene-rich bio-based carbon materials and graphene-decorated carbon fibers, and to develop scalable and cost-effective atomic layer deposition (ALD) manufacturing technology to fabricate totally eco-friendly supercapacitors with energy density reaching > 50 Wh/kg that is comparable to batteries without sacrificing the power density, cycle life or eco-friendliness, and open up opportunities to establish a new value chain for supercapacitor manufacturing with European SMEs as key players. The consortium will achieve this goal by a combination of factors, working in a coordinated fashion: process modification to enable production of high-graphene-content porous carbon for printed flexible energy storage, conformal graphene coating onto carbon fibres for structural supercapacitors, decoration of both types of electrodes with ultra-thin conformal ALD coating of MnO2 and Fe2O3 for increased stability and voltage window (to be scaled up to roll-to-roll by Beneq), and development of novel, environmentally-friendly electrolytes. The energy storage devices enabled by this work will be integrated into two use-case demonstrators to show the viability of the concept: a wireless sensor device powered a printed flexible supercapacitor, and a drone powered by structural supercapacitors which are simultaneously structural parts of the drone.

Keywords: graphene,energy storage,supercapacitor,biocarbon,ald,printed flexible structural electrolyte,lca,supersonic
Influence of Climate variability on the Gravettian cultural Diversity and Evolution (ClimDivE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

Currently facing major environmental changes due to global warming, a growing concern of modern societies is related to how we will be able to cope with these rapid changes to survive. This kind of preoccupation is probably not new: over the course of its history, the human species has been able to adapt to very different environmental conditions thanks to diversified cultural adaptations. The objective of the project “ClimDivE” is to understand the role of environmental change in the diversity and evolution of cultural adaptations at large geographic and chronological scales, using the archaeological record of the Gravettian (32-26 000 years before present) as an example framework. At this period, archaeologists have shown that two neighboring regions, Western and Central Europe, exhibit very different cultural trajectories, without being able to understand the large-scale mechanism that influenced this pattern. The ClimDivE project aims to explore the factors composing this mechanism by integrating archaeological data and paleoclimate simulations into a unified approach: “Eco-cultural niche modeling”. This approach derived from the field of distributional ecology allows one to identify the environmental conditions associated with specific cultural traits. To do so, Dr. Vignoles will gather pertinent archaeological occurrences and environmental variables for the Central European Gravettian. These data will feed a mathematical model that represents the niche. These results will be compared with her previous work on the Western European Gravettian. Based at Liège with shorter stays in Kansas University and Paris-Saclay, the research will be supervised by three internationally recognized researchers specialized in the Gravettian, ecology and paleoclimatology. The proposal will result in a model underlining different types of factors – environmental, cultural, demographical – probably implicated in the separate evolution of neighboring regions during the Gravettian.

Keywords: eco cultural niche modeling gravettian upper palaeolithic cultural traditions cultural evolution central europe western europe paleoclimate modeling
Unveiling the infancy of planetary systems (UNVEIL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1498850.0
EU funding (EUR): 1498850.0
Participants: 1
Project status: SIGNED

Observational campaigns are revealing that planet formation is an extremely efficient mechanism, and that at the same time it leads to a wide diversity in exoplanet properties. While high resolution images of protoplanetary disks show potential signatures of planet-disk interactions, an observational characterization of directly imaged protoplanets interacting with their natal environment is still lacking, limiting our understanding of the planet formation mechanisms. Thanks to the revolutionary capabilities of the ALMA interferometer, and the advent of upcoming infrared facilities such as JWST, the time is ripe to finally detect planets in the act of formation, and observe how their bulk and atmospheric properties is determined by the physics and chemistry of their birth surroundings. UNVEIL will bridge the gap between exoplanets and planet forming disks by directly observing and modelling the assembly of massive planets in disks at large orbital radii. Combining cutting-edge observational programs and ambitious modelling efforts, I will: a) assess the onset of hydrodynamical instabilities facilitating the formation of planetary cores; b) search for protoplanets in the gas kinematics of disks and estimate their mass; c) image protoplanets in the mid-infrared and determine how they formed; d) directly connect the chemistry of disks to the elemental abundances of protoplanet atmospheres. This ambitious project builds upon a novel methodology that will be developed by my team to detect protoplanets in the kinematical structure of protoplanetary disks, and on my leadership position in a pioneering ALMA Large Program to characterize the gas kinematics of planet-forming disks. In synergy with my ground-breaking JWST observations, UNVEIL will build a unique legacy for the whole community, and provide observational constraints that are sorely needed to unveil the formation phases of cores and atmospheres of Saturn-Jupiter mass exoplanets.

Keywords: direct imaging sub mm astronomy hydrodynamics astrochemistry
A Post Growth Deal (REAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,Switzerland
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-05-01
End date: 2029-04-30
Duration (months): 72.0
Total project cost (EUR): 9994960.0
EU funding (EUR): 9994960.0
Participants: 2
Project status: SIGNED

How can we sustain human well-being within planetary boundaries? What policies and provisioning systems could enable societies to prosper without growth? What politics and alliances are necessary for seeing post-growth policies through, and how can the public be engaged in them? What new scientific paradigm could answer such questions? Societies face multiple intertwined crises. Bold alternatives are sorely needed. This project develops frameworks for ‘Post-Growth Deals’, from empirical research through to practical applications. First, we develop equitable North-South convergence scenarios, modelling human well-being achievement in all countries within planetary boundaries. Second, we articulate post-growth policy packages for the Global North and South, assessing their political acceptability and modelling their effects. Third, we develop models of provisioning systems to ensure future populations have adequate energy, food, shelter, health and social security. Fourth, we learn from political movements, studying politics and alliances that could bring post-growth transitions forward. Fifth, we identify practical steps to bring Post-Growth Deals to life, working with four representative communities to co-produce knowledge and action on the ground. The potential gains of this research are immense: post-growth transitions may unlock a far more ecologically stable and socially prosperous future than current trajectories lead to. REAL brings a paradigm shift moving post-growth science from economics to sustainability studies. We propose a new trans-disciplinary ‘5Ps of post-growth’ science, grounded in resource/energy modelling, political-economy and socio-political analysis – a skill-set that no single researcher or team presently possesses. The PIs are leaders in their fields and bring complementary expertise in: modelling of provisioning systems (JST), political economy and North-South relations (JΗ), and the politics of socio-environmental transformations (GK).

Keywords: limits to growth,post growth,degrowth,ecological economics,political ecology,industrial ecology,unequal exchange,environmental justice,climate justice,provisioning systems,planetary boundaries,wellbeing