Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Researchers' Night Apulia 2020 - Discovering the fascinating world of research (ERN-Apulia2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy,Italy,Italy,Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-03-31
Duration (months): 10.0
Total project cost (EUR): 132000.0
EU funding (EUR): 132000.0
Participants: 12
Project status: CLOSED

ERN-Apulia2 targets to continue bringing Apulian population closer to the research and viceversa. Apulia is an Italian region with about 4.1 million inhabitants and 4 public universities having a total of about 2800 permanent researchers in addition to those in Public and Private Research Institutions. The large capacity of beneficiaries was already demonstrated in the past EU-funded project for 2018 and 2019 Nights. ERN-Apulia2 further enlarged the network of partners in order to overpass its previous achievements. Main objectives are: - to implement preparatory events and the 2020 ERN, with particular attention to students, industrial and professional organizations, municipalities and public administrations, already actively involved in the past editions; - to increase public awareness and recognition of the importance and impact of research in daily life, with specific examples from ICT to health and life sciences, from elementary particle to the preservation of cultural heritage, etc with a special emphasis on sustainability for the 2020 edition; - to stimulate curiosity and interest and explain the fascinating world and the opportunities in research, especially to the youngest as a mean to encourage them to embark scientific careers; - to establish a tight connection among population/institutions and researcher to continue during the year; - to prepare and publicize dissemination materials along with scientific games and site visits (including laboratories and sites of cultural interest) to be available during the whole year for the general public; - to explain the spirit and opportunities of the European Research Area, the H2020 agenda, the Marie Skłodowska-Curie actions and the principles of “The European Charter for Researchers”; - to reach a number of followers close to 200,000, a number of participants larger than 100,000 (among all the various initiatives) and a number of participants to the ERN larger than 50,000.

Keywords: european researchers night,research dissemination,outreach,public awareness
A world without objects: the metaphysics of indeterminacy in ancient philosophy, from Democritus to Aenesidemus. (AWWO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The proposed project aims at investigating the metaphysics of indeterminacy in ancient philosophy. By relying on the aid of contemporary metaphysics (in particular, Van Inwagen's materialism and Merricks', and Stage-theory of material objects), the project will show that the metaphysics of indeterminacy was an important, yet neglected, part of ancient metaphysics, from the time of Democritus to that of Aenesidemus. The project will deal with a variety of Greek philosophers, traditionally understood as subjectivists (this very general label as meant to include relativists, sceptics, infallibilists and nihilists). These are the following ones: Democritus, Protagoras and Gorgias, Heraclitus, the Socratic schools of the Cyrenaics (including later exponents of the school, such as Theodorus the Godless) and the Megarians (Euclides, Eubulides, Diodorus Cronus, Stilpo), Pyrrho and neo-pyrrhonism (Aenesidemus). The project will demonstrate that, although in different ways, all the philosophers just mentioned adhered to a view of the world according to which either 1) objects of perception are indeterminate with regard to their properties or 2) objects in themselves are best understood as indeterminate items (in particular, on this latter view, objects as stable and unitary items are denied to be existing). The project is both historical and philosophical, in so far as not only does it attempt to reconstruct the details of ancient conceptions of metaphysical indeterminacy, but it will also try to demonstrate the philosophical viability of those conceptions by drawing close parallelisms with current theories of metaphysical indeterminacy. To appreciate the pervasiveness of metaphysical indeterminacy in ancient Greek philosophy is tantamount to providing a revolutionary insight in the history of ancient metaphysics (and of metaphysics tout court) by challenging the standard view that sees it dominated by Plato’s and Aristotle’s different, yet cognate, essentialisms.

Keywords: metaphysical indeterminacy,democritus,protagoras,gorgias,the cyrenaics,the megarians,pyrrho,aenesidemus,peter van inwagen,trenton merricks,stage theory
High Resolution Mapping of Fetal and Adult B Cell Fates During Ontogeny (FatemapB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 1499905.0
EU funding (EUR): 1499905.0
Participants: 1
Project status: CLOSED

FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells (HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The lineage identity of fetal HSPCs, and the extent of their contribution to the adult immune repertoire remain surprisingly unclear. I previously identified the fetal specific RNA binding protein Lin28b as a post-transcriptional molecular switch capable of inducing fetal-like hematopoiesis in adult bone marrow HSPCs (Yuan et al. Science, 2012). This discovery has afforded me with unique perspectives on the formation of the mammalian immune system. The concept that the mature immune system is a mosaic of fetal and adult derived cell types is addressed herein with an emphasis on the B cell lineage. We will use two complementary lineage-tracing technologies to stratify the immune system as a function of developmental time, generating fundamental insight into the division of labor between fetal and adult HSPCs that ultimately provides effective host protection. Aim 1. Determine the qualitative and quantitative contribution of fetal HSPCs to the mature immune repertoire in situ through Cre recombination mediated lineage-tracing. Aim 2. Resolve the disputed lineage relationship between fetal derived B1a cells and adult derived B2 cells by single cell lineage-tracing using cellular barcoding in vivo. Aim 3. Characterize the mechanism and effector functions of Lin28b induced B1a cell development for assessing the clinical utility of inducible fetal-like lymphopoiesis. The implications of FateMapB extend beyond normal development to immune regeneration and age-related features of leukemogenesis. Finally, our combinatorial lineage-tracing approach enables dissection of cell fates with previously unattainable resolution.

Keywords: hematopoiesis,fetal liver,lineage tracing,cellular barcoding
ConfocAl Microscopy and real-time Rheology of dynamIc hyroGels (CAM-RIG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2023-10-31
Duration (months): 78.0
Total project cost (EUR): 2038120.0
EU funding (EUR): 2038120.0
Participants: 1
Project status: SIGNED

Hydrogels cross-linked through supramolecular interactions are highly dependant on the dynamic charac- teristics of the physical cross-links. Few fundamental studies have been undertaken to quantitatively de- scribe structure-property relationships for these types of systems. Hydrogels formed from CB[8]-mediated supramolecular physical cross-linking mechanisms have gained significant interest on account of their excel- lent physical and mechanical properties such as self-healing and shear-thinning. This supramolecular motif has been further exploited to introduce and compatibilise a wide variety of different materials into hydrogel networks without phase separation, forming hybrid composite hydrogels attributed with unique and emergent properties. This proposal aims to pioneer the combination of several state-of-the-art characterisation tech- niques into an unique experimental setup (CAM-RIG), which will combine super-resolution and confocal microscopy imaging modalities with simultaneous strain-controlled rheological measurements to investigate fundamental structure-property relationships of these systems. For the first time it will be possible to decon- volute the molecular-level dynamics of the supramolecular physical cross-links from chain entanglement of the polymeric networks and understand their relative contributions on the resultant properties of the hydrogels. Using the fundamental insight gained, a set of key parameters will be determined to maximise the potential of supramolecular biocompatible hydrogels, driving paradigm shifts in sustainable science and biomaterial applications through the precise tuning of physical properties.

Keywords: host guest chemistry,supramolecular hydrogel,cucurbituril,dynamics
Shaping of long term innate immunity by viral education of bone marrow monocytes (VIROME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1499950.0
EU funding (EUR): 1499950.0
Participants: 1
Project status: SIGNED

Symbiotic and pathogenic microbes are major environmental factors that play fundamental roles in shaping host immunity. Such dynamic interactions between commensals or pathogens and the host must be finely regulated to balance protective immune responses and induction of regulatory pathways. While frequently underestimated, immune imprinting by viruses is a key determinant for variation in disease susceptibility. Numerous evidence shows that a history of infections trains the innate immune system for the long term. Amongst the cells that are trained, monocytes are highly heterogeneous and are involved in essential biological processes such as anti-microbial activity, immunomodulation or macrophage-niche replenishment. While the current paradigm states that monocyte fate and function are driven by the local microenvironment, a recent study has shown that monocytes are primed in the bone marrow for functional properties. Here, we want to explore how and where monocyte development and function are educated by symbiotic (Murid herpesvirus 4) or pathogenic (Pneumonia Virus of Mice) viruses and with which potential outcomes for long-term immunity. To this end, we have devised three main aims. First, following infections, we will characterize monocytes and their progenitors by classical immunophenotyping, functional assays and unbiased single-cell RNA-seq in combination with ATAC-seq, to investigate in-depth how and where viruses shape monocytes and monocyte-derived cells. Second, molecular mechanism(s) underlying monocyte priming after infections will be assessed. In particular, based on literature and preliminary results, we postulate that bone marrow CD169+ macrophages could play a key role in early monocyte priming. Third, the consequences of virus-driven monocyte training will be investigated at steady state and upon heterologous challenges. Such research could provide the proof of concept that viral education of bone marrow monocytes shapes long-term innate immunity.

Keywords: symbiotic and pathogenic viruses,bone marrow monocyte imprinting,long term traning immunity,bone marrow cd169 macrophages,transcriptomic and epigenetic profiling,mouse models
ENDOSCAPE, a clinically applicable non-viral gene delivery technology (ENDOSCAPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Germany,Switzerland,Belgium,France,Netherlands
Call: Innovation platforms for advanced therapies of the future (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 6850643.75
EU funding (EUR): 6850643.75
Participants: 13
Project status: SIGNED

Gene therapy is one of the most promising treatment options for future advanced therapies in a broad range of diseases. Successful gene delivery requires the recognition of target cells as well as cytosolic and nucleosolic uptake of the gene. Currently, non-viral based gene delivery such as transfection reagents are only suitable for in vitro applications, and clinical gene therapeutics delivery is accomplished via viral vectors, which still has major safety concerns as well as complex and costly manufacturing procedures, preventing future implementation for the treatment of diseases with large patients groups. In the last 15 years, a class of secondary plant metabolites has been discovered that selectively mediates endosomal escape and cytoplasmic delivery of macromolecules specifically at low endosomal pH, thereby inducing a 40-fold enhanced gene delivery efficacy in vivo. However, endosomal escape enhancers and gene therapeutic product must be applied as two components, thus complicating therapeutic approval and clinical applicability. The ENDOSCAPE technology platform will develop and collect proof of concept for a non-viral gene delivery technology where endosomal escape enhancers, gene therapeutic product and targeting ligand are all bound to one molecular scaffold. Proof of concept of the ENDOSCAPE technology has a major impact on the therapeutic opportunities for current and future macromolecule drugs for a broad range of diseases and large patient groups. All this induces new biotech-based businesses, new research projects and creates new technology platforms for development of new macromolecule therapeutics for a broad range of disease indications. The non-viral based ENDOSCAPE technology will enhance therapeutic efficacy with lower therapeutic dose thereby reducing costs of healthcare, improving the health of patients worldwide, and strengthening the competitive landscape of the EU in the worldwide quest for such an advanced technology.

Keywords: targeted non viral gene delivery,endosomal escape enhancers,plant secondary metabolites production process development,click chemistry
The SUPPMIL project investigates the drivers of individual politicians and political parties’ support for United Nations and NATO military operations abroad. (SUPPMIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 271732.8
EU funding (EUR): 271732.8
Participants: 2
Project status: CLOSED

Why do national political parties and individual members of parliament (MPs) adopt different attitudes towards UN and NATO operations? To tackle this question, the project adopts a multi-method approach and brings together quantitative text analysis and case-studies investigation. First, the quantitative text analysis addresses thirty years of parliamentary debates in Canada, Germany, Italy, UK, and US, and discussions in the UN Security Council (UNSC) and in the North Atlantic Council. Second, the project entails case studies on two UN missions, the UN Organization Stabilization Mission in the DR Congo, and the UN Interim Force in Lebanon and two NATO missions, Kosovo and Afghanistan. Results of the multi-method analysis enrich the theoretical debate about the factors that explain levels of support for military missions: the elaboration and the empirical testing of two unified theories for MPs and political parties’ positions on armed interventions abroad is a key innovative contribution. Second, the case-studies analysis provides novel insights about states and parties’ rhetoric and behaviour, contributing to relevant academic debates on international norms, rhetorical political analysis, and organised hypocrisy. The theoretical implications range from the political salience of different missions to the discrepancies of Foreign Policy positions over the domestic-international divide. In addition, the project provides significant methodological improvements. The combination of quantitative with qualitative text-analysis tools offers intriguing insights about the strengths and weaknesses of the two approaches and about the potential for their interaction. Finally, the project aims at refining the rigorousness of Bayesian process tracing, building systematic rules to assign different causal weights to different observations. In this context, the employment of MPs’ personal characteristics and institutional roles to establish such rules seems a promising path.

Keywords: multilateral military missions,political attitudes,foreign policy analysis,quantitative text analysis
Adaptive multi-tier intelligent data manager for Exascale (ADMIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EuroHPC (Art-187)
Countries involved: Germany,Germany,Italy,Italy,Italy,Italy,Italy,Germany,Germany,Spain,Italy,Italy,Spain,Sweden,Poland,France,France,France,France
Call: Extreme scale computing and data driven technologies (H2020-JTI-EuroHPC-2019-1, 2019)
Start date: 2021-04-01
End date: 2024-03-31
Duration (months): 36.0
Total project cost (EUR): 7963286.25
EU funding (EUR): 3981643.13
Participants: 19
Project status: SIGNED

The growing need to process extremely large data sets is one of the main drivers for building exascale HPC systems today. However, the flat storage hierarchies found in classic HPC architectures no longer satisfy the performance requirements of data-processing applications. Uncoordinated file access in combination with limited bandwidth make the centralised back-end parallel file system a serious bottleneck. At the same time, emerging multi-tier storage hierarchies come with the potential to remove this barrier. But maximising performance still requires careful control to avoid congestion and balance computational with storage performance. Unfortunately, appropriate interfaces and policies for managing such an enhanced I/O stack are still lacking. The main objective of the ADMIRE project is to establish this control by creating an active I/O stack that dynamically adjusts computation and storage requirements through intelligent global coordination, malleability of computation and I/O, and the scheduling of storage resources along all levels of the storage hierarchy. To achieve this, we will develop a software-defined framework based on the principles of scalable monitoring and control, separated control and data paths, and the orchestration of key system components and applications through embedded control points. Our software-only solution will allow the throughput of HPC systems and the performance of individual applications to be substantially increased – and consequently energy consumption to be decreased – by taking advantage of fast and power-efficient node-local storage tiers using novel, European ad-hoc storage systems and in-transit/in-situ processing facilities. Furthermore, our enhanced I/O stack will offer quality-of-service (QoS) and resilience. An integrated and operational prototype will be validated with several use cases from various domains, including climate/weather, life sciences, physics, remote sensing, and deep learning.

Keywords: high performance i,ad hoc storage systems,malleability,o scheduling,intelligent i,o tuning,cross layer data analytics,heterogeneous dataset,applications co design,exascale