Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Acoustic sensor solutions integrated with digital technologies as key enablers for emerging applications fostering society 5.0 (Listen2Future)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Austria,Belgium,Czechia,Germany,Norway,Spain,Netherlands
Call: HORIZON-KDT-JU-2021-2-RIA (HORIZON-KDT-JU-2021-2-RIA, 2021)
Start date: 2023-02-01
End date: 2026-04-30
Duration (months): 39.0
Total project cost (EUR): 29429703.25
EU funding (EUR): 9145618.02
Participants: 29
Project status: SIGNED

Listen2Future will boost the potential of piezoelectric acoustic transducers to provide new solutions in the key application areas of Health & Wellbeing and Digital Industry & Energy. Acoustic transducer solutions and the key underlying technologies are addressing many of the challenges in emerging applications towards a more digitalized society. Indeed, growing demand for MEMS-based acoustic transducers (microphones, ultrasonic transducers) in medical and industrial devices are creating a new high demand for miniaturized low power sensors. In combination with an intelligent signal processing system, algorithms and customized packaging, these technologies will be the key to achieve performant, low power consuming, miniaturized and cost-saving systems. The demonstrators will address 14 use-cases in LISTEN2FUTURE with their benchmark in low power consumption, small size and low cost to open the door for disruptive acoustic applications. Major impact on quality of live for humans as well as on industrial and medical appliances can be expected. The European Position in Acoustic Sensors will be therefore strengthened by new piezoelectric materials and technologies with the capability to outperform the existing ones that are based on capacitive MEMS technologies. This will contribute to reinforcing the Union's strategic autonomy in electronic components and systems to support future needs of vertical industries and the economy at large. The growth of the microphone market (8 -> 14bio. units in 5 years) and the growth of the Ultrasound sensing modules market (500mio -> 800mio in 3 years) should be predominantly covered with acoustic sensors made in Europe. The double transition of European Union toward digital and greener society there poses a high demand for reliable and secure data. Our integral acoustic sensor solutions are listening to these needs and mapping the acoustic senses and perceptions into Society 5.0.

Keywords: mems,transducers,piezoelectric thin films,ultrasound,mems microphone,pmut,ultrasound patch,ultrasound diagnostics,ultrasound positioning,hearing aid,continuous patient monitoring,
Bioengineering an Innervated 3D Skeletal Muscle Model to Replicate Contractile Dysfunction in Neuromuscular Disorders (InnervateNMD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

Neuromuscular disorders (NMDs) encompass a diverse group of diseases that severely impact patients' quality of life and reduce life expectancy. Despite the urgent need, only a handful of these disorders are currently treatable. A major barrier to therapeutic development is the lack of humanized models that can accurately reflect the complex neuromuscular phenotypes observed in patients. Recent advancements in cell culture techniques have enabled the development of functional 3D-tissue-engineered skeletal muscles (3D-TESMs), offering a promising platform to study NMDs. However, the integration of motor neurons and neuromuscular junctions (NMJs) in these models remains challenging. In this project, I aim to bridge this critical gap by leveraging my background in developing in vitro muscle models and the host lab's expertise in peripheral nerve biology. Together, we will develop innervated cell models capable of contractile functioning using human-induced pluripotent stem cell-derived muscle cells and motor neurons. By integrating 3D-printing technologies and a customized high-density multielectrode array, I plan to generate two innervated 3D-TESM cell models to study both the muscular and neuronal aspects of NMDs. As a proof-of-concept, these models will be applied to study the effects of axonal Charcot-Marie-Tooth disease (CMT2), illustrating their potential for investigating NMDs. Overall, the development of innervated 3D-TESMs will represent a significant step forward in creating more accurate humanized systems to study NMDs and accelerate the development of effective therapeutics.

Keywords: charcot marie tooth disease,neuromuscular disorders
An open-source platform for Resilient sECure digITAL identitieS (RECITALS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Greece,Netherlands,France,Portugal,Romania,Germany,Ireland,Cyprus
Call: Privacy-preserving and identity management technologies (HORIZON-CL3-2023-CS-01, 2023)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 4563062.5
EU funding (EUR): 3935331.25
Participants: 10
Project status: SIGNED

RECITALS aims to build an open-source platform that integrates into a common framework a wide variety of techniques and services for privacy-preserving data sharing and identity management. The platform consists of three main modules: 1) RECITALS core provides a series of fundamental components that can be used as building blocks for constructing more complex services. These include: the distributed ledger, the identity lifecycle manager, the cryptography manager, the anonymization manager as well as the compliance manager for horizontal EU legislation. 2) RECITALS value-added services combine multiple components from RECITALS core into end-to-end pipelines that address specific needs: a self-sovereign wallet, privacy-preserving record linkage, privacy-preserving federated learning, LLM-based user interface, domain-specific compliance manager, privacy-preserving data analytics and explAIner, which sheds light into the decisions taken by trained ML and DL models. 3) Security Manager provides all necessary means for ensuring the resilience of the entire platform. To this end, it covers all aspects of cyber-security, from the analysis of possible cyber-attacks to their automatic detection and mitigation. Special care is taken to equip each component with the state-of-the-art techniques of the corresponding task. As a result, each component acts as a library comprising a wide variety of established methods and can be used independently of the platform, for example by being integrated into any other system that leverages Python's open-source ecosystem. Another goal is to tweak the methods implemented by each component so as to enhance their time efficiency and scalability. The performance of the RECITALS platform will be tested in three demanding industrial use cases, to evaluate and verify its capabilities, while demonstrating how it goes beyond the current state-of-the-art in each considered field.

Keywords: open source platform,value added services,federated learning,identity management
Creating leverage to enhance biodiversity outcomes of global biomass trade (CLEVER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Brazil,United Kingdom,Spain,Finland,Sweden,Cameroon
Call: Quantify impacts of the trade in raw and processed biomass on ecosystems, for offering new leverage points for biodiversity conservation, along supply chains, to reduce leakage effects (HORIZON-CL6-2021-BIODIV-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 2674508.75
EU funding (EUR): 2674508.0
Participants: 12
Project status: SIGNED

CLEVER identifies new leverage points for sustainable transformation informed by a novel holistic approach to quantify biodiversity and other impacts of trade in major raw and processed non-food biomass value chains. In line with Pillars 3 & 4 of the EU Biodiversity Strategy 2030, we address all outcomes of this topic by adopting perspectives at the system and value chain levels. At the system level, we improve our understanding of leakage effects in the non-food biomass trade system informed by quasi-experimental evaluation techniques, quantitative scenario modelling, and policy case studies. At the value chain level, CLEVER engages with key stakeholders (i.e., producers, traders, retailers, civil society, and policy makers) in R&I co-design to identify leverage points for transformative change at corporate and institutional levels. Value chain analyses will produce ‘ecological footprints’ from advanced life cycle analyses and enhance our understanding of actor-specific behavior focusing on trade in soy, timber, wood pulp, and fishmeal/oil between Europe, South America, and Central Africa. Further CLEVER products and tools to influence decision-making at the right level include (1) improved indicators of biodiversity loss to inform business and policy, (2) enhanced features for the global modelling platform GLOBIOM to quantify trade-mediated leakage and SDG interdependencies in biomass value chains, and (3) an innovation action pool to support public and private decision-makers in choosing governance instruments that effectively enhance biodiversity and promote climate change mitigation and adaptation. Building on prior and ongoing engagement of its members at the science-policy interface and through partnerships with other projects under the destination on biodiversity and ecosystem services, the consortium will leverage CLEVER knowledge and tools to strengthen IPBES and IPCC and enhance science-industry cooperation for sustainable bioeconomic transformation.

Keywords: biodiversity,bioeconomy,leakage,ecological footprints,randi co design,soy,timber,wood pulp,fishmeal,fish oil,central africa,south america,europe,value chain governance,leverage points
Patents, Bioethics and the Human Body: Reconceptualising Bioethics in Patent Decision-Making and the Governance Function of Patents (PatentsInHumans)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1499958.75
EU funding (EUR): 1499958.75
Participants: 1
Project status: SIGNED

PatentsInHumans challenges the current marginalisation of bioethics in patent decision-making for technologies related to the human body. A patent gives a rightsholder the right to stop others using a patented technology. This allows them to control how that technology is provided, to whom, and on what terms. Where patents are for technologies related to the body, this control poses considerable bioethical issues because patents can affect how we treat, use and modify bodies. Yet patent systems generally do not engage with such implications. All patents are treated the same, regardless of the underlying technology i.e. a patent on an engine part is treated the same as a patent on a medicine, despite the significant effects the latter has for health. PatentsInHumans proposes that there is a self-reinforcing cycle where patents are granted even if bioethical implications are posed by patents over such technologies; that there are limited incentives for rightsholders to license patents in a way that addresses bioethical implications, and that patents, once granted, are difficult to challenge if bioethical issues arise. PatentsInHumans radically reconceptualises patents as governance devices over the body in such contexts. It proposes that when patents are applied for, the underlying technology’s relationship to the body must be considered. The project will therefore evaluate the bioethical implications that patents over such technologies have for how we treat, use, or modify our bodies. These implications must guide patent decision-making and the adoption of licensing or grant conditions that pre-empt bioethical issues. The project develops a cross disciplinary institutional analysis to evaluate key legal, structural and cultural barriers leading to the marginalisation of bioethics in patent decision-making, and to formulate pathways to bring bioethics into patent decision-making for technologies related to the body with important conceptual and policy implications

Keywords: patents and bioethics patents and morality biotechnology directive european patent exclusions
Towards a circular degrowth economy: Explaining the material valorization regime of city-regions (DECYCLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1431711.0
EU funding (EUR): 1431711.0
Participants: 1
Project status: SIGNED

A transition towards a degrowth economy is necessary to tackle the related challenges of resource scarcity and waste accumulation. Degrowth pursues socio-economic wealth while reducing material flows and reusing waste in socially responsible and ecologically regenerative ways. As a concrete approach to realizing these ends, the concept of the circular economy has gathered political momentum. However, this model will have no impact on city-regions' ecological footprint unless it challenges the regulations that dismiss certain materials as waste in the first place. DECYCLE lays the groundwork for studying the regulatory frameworks that make it possible to revalue waste materials as a resource for city-regional development. It develops an approach termed 'institutional urban political ecology', which combines city-regions' regulatory, spatial, and ecological dimensions, usually studied separately. It interrogates the legal, spatial, and economic regulations that define waste streams' political responsibilities, geographies, and financial architecture. DECYCLE puts forward a new concept, the material valorization regime, to explain how these regulations govern the valorization of waste across multiple scales. It develops a distinct new method of 'enactment tracing' for critical urban research, which involves mapping actors engaged in defending and contesting regulations. DECYCLE comparatively analyzes how regulations valorize streams of construction, food, and heat waste in Hamburg, Amsterdam, Barcelona, Vienna, and Milan. It also explains how transnational regulatory frameworks affect waste reduction at the city-regional scale. By theorizing the relationship between regulatory change and the urban metabolism in contemporary eco-capitalism, DECYCLE sets out to free urbanization from its dependency on the production of waste and raw materials. In so doing, it lays the foundations for future socio-spatial inquiry into the institutional basis of city-regional metabolisms.

Keywords: urban degrowth degrowth political ecology circular economy of cities planning institutions regulations of ecological capitalism urban waste materials urban political ecology of waste
Deciphering the Oxidizing Capacity of the PAST atmosphere (DOC-PAST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2029-03-31
Duration (months): 78.0
Total project cost (EUR): 3186183.0
EU funding (EUR): 3186183.0
Participants: 2
Project status: SIGNED

Atmospheric chemistry is an essential component of the functioning of the Earth's climate. It determines the atmospheric lifetime of most climatic agents, impacting the nature and concentrations of aerosols, greenhouse gases, cloud formations. Determining how this chemical reactivity has evolved in the past is essential, both for evaluating chemistry-climate models (CCM) and for establishing future climate trajectories. The chemical activity of the atmosphere is driven by highly reactive atmospheric compounds that have a very short lifetime in the atmosphere. Because of this ephemeral nature, they are not archived in the paleoclimate record. Reconstructing this chemical activity over time remains a difficult exercise that has not been successful to date. Using ice cores, the multidisciplinary DOC-PAST project proposes to develop new tracers of this chemical activity by taking advantage of the revolution introduced by clumps and isotopic anomalies. The aim is to use a variety of ice cores covering all latitudes to highlight key elements of the chemical reactivity of the atmosphere. This will be done by 1-determining in the laboratory the isotopic characteristics of key oxidation reactions of atmospheric of compounds preserved in the ice, 2-documenting in the ice archives these isotopic compositions and deducing the associated chemical reactivity of the atmosphere 3-incorporating in the CCM LMDz-INCA these changes and measuring their impacts on climate. These new isotopic proxies will require the development of new analytical approaches based on the retargeting of an orbitrap towards isotopic measurements and the construction of a very high sensitivity infrared spectrometer, paving the way for the use of clumped isotope in broad disciplinary fields using stable isotopes. DOC-PAST will provide for the first time in situ “chirurgical-level” of how atmospheric species are made with unparalleled mechanistic details and set new standards in geochemistry and spectroscopy.

Keywords: mass spectrometry,infrared spectroscopy,ice cores,clumped isotope,nitrate,sulfate,carbon monoxide
TIER2: ENHANCING TRUST, INTEGRITY AND EFFICIENCY IN RESEARCH THROUGH NEXT-LEVEL REPRODUCIBILITY IMPACT PATHWAYS (TIER2)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Research and Innovation actions
Countries involved: Austria,Greece,Netherlands,Denmark,Bulgaria,Germany,United Kingdom
Call: Increasing the reproducibility of scientific results (HORIZON-WIDERA-2022-ERA-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1791500.0
EU funding (EUR): 1791500.0
Participants: 10
Project status: SIGNED

Lack of reproducibility of research results has become a major theme in recent years. As we emerge from the COVID-19 pandemic, economic pressures (increasing scrutiny of research funding) and exposed consequences of lack of societal trust in science make addressing reproducibility of urgent importance. TIER2 does so by selecting 3 broad research areas (social, life and computer sciences) and 2 cross-disciplinary stakeholder groups (research publishers and funders) to systematically investigate reproducibility across contexts. The project starts by thoroughly examining the epistemological, social and technical factors (epistemic diversity) which shape the meanings and implications of reproducibility across contexts. Next, we build a state-of-the-art evidence-base on existing reproducibility interventions, tools and practices, identifying key knowledge gaps. Then TIER2 will use (co-creation) techniques of scenario-planning, backcasting and user-centred design to select, prioritise, design/adapt and implement new tools/practices to enhance reproducibility across contexts. Alignment activities ensure tools are EOSC-interoperable, & capacity-building actions with communities (i.e., Reproducibility Networks) will facilitate awareness, skills and community-uptake. Systematic assessment of the efficacy of interventions across contexts will synthesise knowledge on reproducibility gains and savings. A final roadmap for future reproducibility, including policy recommendations is co-created with stakeholders. Thus, TIER2 will significantly boost knowledge on reproducibility, create tools, engage communities, implement interventions and policy across different contexts to increase re-use and overall quality of research results in the European Research Area and global R&I, and consequently increase trust, integrity and efficiency in research.

Keywords: reproducibility,open science,trust,integrity,efficiency,epistemic diversity,co creation
iSPEAK: a Natural Language Processing Study in youth with subclinical psychotic experiences (iSPEAK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

Up to one fifth of young people report that they have experienced unusual perceptual experiences, thoughts or beliefs. These experiences (which we call Psychotic Experiences or PE) can take the form of hearing voices or seeing visions or feeling paranoid or believing things that are not true. As part of my ERC Consolidator Award (iHEAR), I and my team have learned a great deal more about these experiences and what they mean for young people. We know that these experiences can be transitory in most cases but that in some young people they recur throughout adolescence and adulthood. We know that, for some young people, these experiences can be associated with poor functioning and poorer mental health but for others they are not pathological. We have identified the need for an instrument that can differentiate between pathological and non-pathological psychotic experiences. This will support early risk screening and development of interventions among those who experience PE. We propose to search for natural language patterns within self-reported PE that are associated with high and low levels of mental ill-health. Our hypothesis is that young people’s first person account of their experiences are likely to contain natural language phrases that could be used to differentiate between PEs that occur in the context of mental ill-health are likely to require intervention and those that do not. Knowledge of natural language patterns for PE would be a valuable step in improving assessment tools in clinical practice. Additionally this could be a valuable new resource for digital tools and e-Health which is a growing area for mental health.