Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PLOCAN Tested Optimised Floating Ocean Thermal Eenergy Conversion Platform (PLOTEC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: United Kingdom,Spain,Portugal,Italy,Austria
Call: Innovative foundations, floating substructures and connection systems for floating PV and ocean energy devices (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-11-01
End date: 2025-04-30
Duration (months): 30.0
Total project cost (EUR): 1322523.08
EU funding (EUR): 1322523.08
Participants: 7
Project status: SUSPENDED

The overall objective for the project is to achieve a successful demonstration of the novel designs and materials for an ocean thermal energy conversion (OTEC) platform capable of converting solar heat energy stored in the oceans surrounding the Overseas Countries and Territories of the EU, Small Islands and Developing States, and the Asian and African continent into reliable, baseload power with an economical cost model. The following objectives have been identified: Technical Specification: Design prototype components using circular materials and computational Modelling tools (Predictive Modelling tools developed and/or refined) Research Material Properties Build and Installation of Demonstrator: Floating Platform & testing in controlled and real-worldsettings Econometric, Environmental and Social Impact Assessments This project marries both technical advancements in marine engineering and new materials and computational modelling enabling lower CAPEX expenditure for Marine Offshore OTEC. These engineering and materials gains are transferable to other renwable energies and their offshore installations, as well as more generally for marine engineering needs. Social, Environmental and Economic impacts are taken account of in this proposal and are the key mechanism for knowlegde creationa nd dissemination.

Keywords: marine engineering floating platform dual use otec rankine cycle materials mooring cylindrical platfrom gimbal sealant
The role of micro-aeration-based processes for the valorisation of polluted sludge to value-added chemicals (OXYCON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-01-31
Duration (months): 25.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

Industrial and municipal biological wastewater treatment plants (WWTP) generate vast amounts of sludge (SS) as a by-product. The total annual production of sludge currently surpasses 13 million tonnes of dry solids (DS) in the EU, even excluding sludge production from industrial on-site WWTP. Sewage sludge (SS) mainly contains non-toxic organic matter that can be converted to value-added compounds such as carboxylic acids, alcohols, and energy carriers. Furthermore, macronutrients such as nitrogen and phosphorus and micronutrients (e.g., potassium and iron) that are essential for crop growth are present as well, making sludge an interesting organic fertiliser. However, mainly depending on the composition of the wastewater and the pollutant’s biodegradability, SS typically contains various potential hazardous contaminants (OMP) such as adsorbable halogenated organic compounds (e.g., PFAS, AOX), phenols, sulfates, aromatics, active pharmaceutical ingredients (APIs) (e.g., antibiotics, endocrine disruptors), pathogens (viruses, bacteria, etc.), microplastics and heavy metals (HM). It is clear that there is an urgent need for technological strategies that tackle both the increasing presence of contaminants in sludge and allow efficient resource recovery from sludge. However, current alternative sludge management strategies fall short to properly respond to the growing demands of a sustainable society and unfortunately, a significant amount of sludge is incinerated or (even worse) landfilled.OXYCON will therefore explore the use of micro-aeration as an innovative technique to simultaneously (i) degrade selected OMP, (ii) remove HMs, and (iii) enhance carboxylic acid production as biobased chemical building block during (subsequent) anaerobic fermentation of the treated sludge. The potential of air will be researched via two different techniques: air-assisted ultrasonication and micro-aeration-based anaerobic fermentation.

Keywords: anaerobic fermentation,sludge management,organic micropollutants,heavy metals
Biodiversity Genomics Europe (BGE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Netherlands,Sweden,Spain,Germany,Norway,Belgium,Slovenia,Poland,Greece,Croatia,Hungary,Ukraine,Canada,United States,United Kingdom,Italy,Finland,Portugal,France,Estonia,Switzerland
Call: European participation in global biodiversity genomics endeavours aimed at identifying all biodiversity on Earth (HORIZON-CL6-2021-BIODIV-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 17159391.25
EU funding (EUR): 17080738.0
Participants: 37
Project status: SIGNED

The Biodiversity Genomics Europe (BGE) ProjectThe Biodiversity Genomics Europe (BGE) Project has the overriding aim of accelerating the application of genomic science to enhance understanding of biodiversity, monitor biodiversity change, and guide interventions to address its decline. BGE coordinates and upscales DNA barcoding and reference genome generation in the context of European biodiversity. The Project develops synergies by aligning efforts and resources of the DNA barcoding and genome sequencing communities across the continent. The BGE objectives with derived ambitions: CAPACITY: To establish functioning biodiversity genomics networks at the European level to connect and grow community capacity to use genomic tools to help tackle the biodiversity crisis With the ambition to (a) Future-proof our networks on biodiversity genomics research, (b) lower access thresholds to biodiversity genomics research, and (c) promote co-creation and citizen engagement. PRODUCTION - To establish and implement large-scale biodiversity genomic data-generating pipelines for Europe to accelerate the production and accessibility of genomic data for biodiversity characterisation, conservation and biomonitoring With the ambition to (a) establish distributed and inclusive capacity, (b) build economies of scale and (c) connect previously disjoined resources to deliver relevant knowledge. APPLICATION - To apply genomic tools to enhance understanding of pan-European biodiversity and biodiversity declines to improve the efficacy of management interventions and biomonitoring programmes. With the ambition to (a) improve the use of biodiversity genomics data in science policy and (b) establish European-wide large scale biodiversity genomics research mechanisms. The BGE Consortium is comprised of 33 partners across 20 countries and brings together, for the first time at this scale, the two communities for barcoding and reference genome to implement its aspirational programme.

Keywords: biodiversity,genomics,barcoding,biomonitoring,infrastructure,conservation
CO2NSTRUCT: Modelling the role of circular economy construction value chains for a carbon-neutral Europe (CO2NSTRUCT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Denmark,Greece,Germany,Portugal,Spain,Italy,United Kingdom
Call: Modelling the role of the circular economy for climate change mitigation (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 4379838.75
EU funding (EUR): 4377332.0
Participants: 7
Project status: SIGNED

Circular Economy integration into climate action and policy is limiting the EU's advancement to achieve carbon neutrality as fast as possible. Widely applied TIMES energy-climate mitigation models detail the use of technology and technological advances in its GHG abatement pathways. Because CE practices are technical, CO2NSTRUCT deems TIMES the ideal proxy model to shift climate mitigation models from linear to circular. This project will delineate a “circular climate mitigation” framework to augment TIMES models at a first stage, but that can serve as an imprint for other climate mitigation models. The focus will be on six pervasive carbon-intensive construction materials – steel, cement, brick, glass, wood, and insulation – to map six value chains with explicit feedback loops and quantified rebound effects, key of CE practices. Social and environmental externalities will be accounted for, including GHG & air pollutants emissions, water usage, embodied energy, energy poverty, employment, and inequalities. Once these and other CE measures are identified in the key industries of the six materials, CE tools as LCA and MFAs can be coupled to the TIMES model. TIMES will run several CE scenarios to quantify the role of CE for EU+ climate mitigation in the near-term and future, always ensuring carbon. Outcomes will be translated into useful and effective policy support information for sustainable climate mitigation, minimising conflicts across SDGs (both in EU+ and rest of the world). Although the framework is applied to the whole EU+ energy production and consumption system (disaggregated per country), CO2NSTRUCT will emphasize two economic case studies or clusters: (1) offshore renewable energy production and (2) buildings. CO2NSTRUCT anticipates that the framework can be used globally by climate mitigation modelers and policy makers. CE integration into climate action will drive EC’s goal to increase EU GDP by 0.5% by 2030.

Keywords: circular economy,value chains,citizen behaviour,construction industry,construction materials
Data driven implementation of hybrid nature based solutions for preventing and managing diffuse pollution from urban water runoff (D4RUNOFF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Denmark,Spain,Italy,Portugal,France
Call: Preventing and managing diffuse pollution in urban water runoff (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 3332948.76
EU funding (EUR): 3332948.75
Participants: 14
Project status: SIGNED

D4RUNOFF overall goal is to create a novel framework for preventing and managing diffuse pollution from urban water runoff through the data driven design of hybrid nature based solutions (NBS) adapted to the current and future risk scenarios solutions. This innovative approach will support water utilities, urban planners and policy makers in defining urban runoff and storm water management plans to enhance the quality of the water discharged to water bodies, considering the Climate Change. D4RUNOFF will have the following specific objectives (SO): - SO1 Increase the knowledge regarding urban runoff pollution sources and the impacts through the development of novel high-resolution suspect and screening & non target screening NTS methods for Contaminants of Emerging Concern (CECs) detection and identification of the major CECs and relevant pollutantspresent in storm water source and assessing their fate in NBS - SO2 Development of cost effective advanced online sensors for targeted CECs, metals and microplastics for improving the monitoring of the water pollution derived from urban runoff - SO3 Enhancing the implementation of advanced preventive and mitigation strategies to reduce diffuse pollution through the development of and innovative multiple-criteria decision analysis (MCDA) methodology integrated in Geographical Information System (GIS) for hybrid NBS design - SO4 Development of a risk assessment and mapping methodology to identify diffuse pollution hotspots for specific sites & considering climate change effects. - SO5 Development of an AI based platform to facilitate the development of effective urban runoff and storm water management plans based on informed decisions - SO6 Implementation and validation of D4RUNOFF approach in 3 case studies and 5 replication sites - SO7 knowledge transfer and engagement with stakeholders, including civil society

Keywords: nature based solutions blue green grey infrastructures measurement methods contaminants emerging concern online sensors risk assessment decission support system
X-ray-induced fluidization: a non-equilibrium pathway to reach glasses at the extremes of their stability range. (GLAXES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2499876.25
EU funding (EUR): 2499876.0
Participants: 1
Project status: SIGNED

I will address the fundamental question of what exactly are and how to prepare glasses at the extremes of their stability range: ultra-stable, ideal glasses on the one side and ultra-unstable, defect-saturated glasses on the opposite side. The ideal glass, predicted by some theories of the glass-transition but not yet observed, is a novel equilibrium state of matter characterized by a fairly unique, dense atomic structure with almost no defects. The defect-saturated glass is instead ductile, at odds with conventional glasses: any additional defect self-heals. I will reach these extraordinary states employing a non-thermal fluidization route activated by X-ray irradiation. Its non-equilibrium nature is key here: conventional thermal treatments, that induce structural changes stabilized by quenching, modify the properties of glasses only over a limited range. My project aims then at: 1. producing ideal and defect-saturated glasses; 2. developing a general scheme to control the stability of glasses; 3. establishing experimentally the connection between their thermodynamic properties and their density of defects; 4. clarifying the microscopic mechanism of X-ray induced fluidization; 5. describing the glass-specificity of this effect in terms of amorphous plasticity. The importance of these extreme glasses is however not only fundamental: the reduced (zero?) density of defects makes the ideal glass mechanically and optically loss-free; a defect-saturated glass, instead, deforms under load and crystallizes very rapidly. Their properties are therefore enabling for new technological applications ranging from noise-free mechanical resonators, superconducting qubits with sufficient coherence for quantum computers and phase-change materials for applications as memories. The long-term vision is that the knowledge of how to measure and control the density of defects in glasses will lead to materials with extraordinary properties of relevance for many important applications.

Keywords: glass transition ultra stable glass defected glass relaxation process amorphous plasticity x ray physics x ray photon correlation spectroscopy photo induced atomic displacement
The impact of 3D regulatory landscapes on the evolution of developmental programs (3D-REVOLUTION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1998217.5
EU funding (EUR): 1998217.5
Participants: 2
Project status: SIGNED

Vertebrate genomes are organized in 3D regulatory landscapes that control pleiotropic gene expression. Within them, transcription emerges from a precise interplay between genes, regulatory elements and 3D chromatin organization. We and others have shown how mutations in these regulatory layers can modulate phenotypes. However, how 3D regulatory landscapes shape the evolutionary history of developmental programs is still largely unexplored. Our limited capability to read, interpret and modify genomes has constrained our knowledge on how gene regulation evolves. However, recent advances in long-range sequencing, single-cell, chromatin interaction and genome editing methods offer novel tools to link genomic variation and phenotypes. Here, I will combine these methods to investigate how changes in 3D regulatory landscapes contribute to refine the function of developmental programs. As a testbed, I will study gonadal sex determination, an essential process for species perpetuation but characterized by a remarkable evolutionary plasticity. We will use single-cell transcriptomics across tetrapod clades to unravel the core and variable transcriptional network of sex determination. Single-cell epigenomics and novel chromatin interaction methods will reconstruct 3D regulatory landscapes and infer sources of regulatory variation. With phylogenomic comparative strategies, we will estimate the contribution of different types of mutations to different sex determination programmes, as well as the impact of whole genome duplications. Finally, we will develop innovative transgenic methods for inter-species replacement of 3D regulatory landscapes, using this technology to activate early estrogen synthesis in mouse. 3D-REVOLUTION will provide ground-breaking insights on the evolution of gene regulation. This will improve our understanding of the genomic sources and underlying mechanisms of phenotypical variation, which are relevant for developmental and evolutionary genetics.

Keywords: 3d chromatin organization
Solid Preparedness And Resilience for Robust Operations during disaster Wilderness (SPARROW)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Research and Innovation actions
Countries involved: Cyprus,Greece,Czechia,Bulgaria,Austria,United Kingdom,Switzerland,France
Call: Design of crisis prevention and preparedness actions in case of digital breakdown (internet, electricity etc.) (HORIZON-CL3-2023-DRS-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 3808562.5
EU funding (EUR): 3808562.5
Participants: 16
Project status: SIGNED

The SPARROW platform represents a pioneering solution for enhancing societal resilience and crisis management in the face of digital breakdowns. Employing a modular architecture encompassing data integration, simulation modeling, and a collaborative platform, SPARROW orchestrates large datasets and expert insights to create a dynamic digital twin of a city. This digital twin, visualized in 3D, becomes a robust testing ground for assessing vulnerabilities and preparing for diverse crisis scenarios. Through a participatory approach involving citizens, local authorities, and first responders, the platform fosters communication during breakdowns and bolsters preparedness against digital threats. SPARROW's innovative tools, including the Emergency Communication Mobile App (ECOMAPP), City Digital Twin (CITWIN), and the Dynamic Critical Asset Management Recommendation Engine (DYCAMARE), are co-designed with stakeholders to ensure user-friendly, effective, and ethically sound functionalities. The platform's impact extends across various sectors, from critical infrastructure managers optimizing maintenance to emergency responders utilizing a mobile 5G network (EMER-5G) for prioritized communication (ECOPRIM). In alignment with EU policies, SPARROW aims to enhance crisis communication, bridge gaps in digital breakdown preparedness, and contribute to a secure and resilient European way of life.
Designing Vascular Geometries in 3D Bioprinted Models for Immuno-oncology (VASPRINT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2028-07-31
Duration (months): 36.0
Total project cost (EUR): 430343.4
EU funding (EUR): 430343.4
Participants: 2
Project status: SIGNED

Cancer is a global challenge. Addressing this, the EU Mission on Cancer aims to improve the lives of >3 million people by 2030. To achieve this goal requires not only new treatments, but also new in vitro platforms to study how their efficacy can be maximised. Cancer immunotherapy has been a promising treatment for certain haematological cancers, but is encountering tremendous challenges when used for solid cancers. One of the main reasons is that tumours are often protected by an immunosuppressive microenvironment that impedes the delivery and infiltration of immune cells, such as T cells. Specifically, the tumour vasculature is both structurally and functionally abnormal, which interrupts the transport of therapeutic T cells to tumour sites. This project (VASPRINT) will fabricate tumour models containing different vascular architectures. To this end, VASPRINT will combine top-down bioprinting with bottom-up self-assembly methods to create hierarchical vascular networks. VASPRINT will employ analytical tools from graph theory and fractal geometry to gain a quantitative understanding of the vascular structures. The engineered tissue model will be used to address a key question: how does tumour vascular geometry influence T cell trafficking? Despite advancements, the specific effects of vascular geometry on T cell trafficking remain poorly understood. This proposal includes learning bioprinting from the Associated Partner (Harvard University), as well as fractal analysis and modelling from the Beneficiary (University College London). In return, the Researcher will contribute his expertise in the algorithmic design of biomaterial structures (outgoing phase) and developing advanced tumour models for T cell therapy research (return phase). This project aims to advance the scientific understanding of tumour vasculature in the context of immuno-oncology, generating useful insights for therapy development, ultimately contributing to the EU Mission on Cancer.

Keywords: bioinspired engineering bioprinting algorithmic design fractals graph theory tumour microenvironment