Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integration of environmental signals in hormonal regulation of decapod crustaceans (MOULTING & CLIMATE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-04-01
End date: 2017-08-05
Duration (months): 36.0
Total project cost (EUR): 263448.6
EU funding (EUR): 263448.6
Participants: 1
Project status: CLOSED

This project aims to improve understanding for the causal relationship between long-term changes of environmental factors elicited by climate change, i.e. temperature and ocean acidification, and organismal performance of an ecologically and economically highly important group of aquatic arthropods. Physiological, biochemical and molecular methods will be used to study how these environmental factors acutely and chronically affect molecular signalling mechanisms of hormonal regulation, growth, acid-base and ion regulation in various life stages of decapod crustacean species from temperate and subpolar latitudes. The life stages and species are expected to show differences in thermal tolerance and in their capacity for hormonal, acid-base and ion regulation, which would reflect differences in the sensitivities to climate change scenarios. This project explicitly addresses drivers of the EU Strategy for Marine and Maritime Research, the Life+ Programme and a major theme of the Cooperation Programme. It will be particularly useful in assessing and predicting vulnerabilities to the increasing environmental pressures on ocean ecosystems and biodiversity due to climate change. Training in molecular cell biology and endocrinology at Colorado State University, Fort Collins, USA and Bodega Marine Laboratory, UC Davis, USA will significantly foster the applicant’s career development and reintegration into the European Research Area at the Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Germany.

Keywords: l807 environmental and marine biology,l402 comparative physiology,l403 endocrinology,l308 signal transduction,l101 molecular biology and interactions,v201 climatology and climate change
The ecology and population dynamics of Wolbachia infections in Aedes aegypti and the development of new strategies for mosquito-borne disease control (WOLBACHIA_MOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-10-14
End date: 2016-10-13
Duration (months): 36.0
Total project cost (EUR): 376536.2
EU funding (EUR): 376536.2
Participants: 1
Project status: CLOSED

An exciting new strategy for biocontrol of mosquito-borne diseases involves the endosymbiotic bacteria Wolbachia that infect several insect species. In the mosquito Aedes aegypti, the major vector of the dengue virus, infection with Wolbachia has been shown to greatly reduce the transmission of human pathogens including the dengue, yellow fever and chikungunya viruses. The Eliminate Dengue project, an international collaboration, is currently developing strategies for releasing Wolbachia into wild A. aegypti populations to render them incapable of transmitting these viruses. The operational success of this strategy relies on the rapid spread of Wolbachia through the mosquito vector population following their initial release. However, the spread of Wolbachia depends on two main factors. Firstly, Wolbachia incur a fitness cost on A. aegypti, which can prevent the bacteria from spreading, particularly if there is a strong fitness cost. In order to design release strategies that will achieve spread, we need to understand the fitness effects of Wolbachia on A. aegypti and how changing environmental conditions influences these effects. Secondly, Wolbachia needs to achieve a threshold prevalence in the mosquito population before it can spread which depends on the fitness cost caused by the bacteria. We need to understand the dynamics of Wolbachia infection in the mosquito population in order to predict release strategies that will allow a sufficiently high prevalence of Wolbachia to be maintained. This fellowship aims to advance our understanding of these ‘individual-level’ and ‘population-level’ processes that determine Wolbachia spread in A. aegypti in order to assist the design of Wolbachia release strategies to successfully drive Wolbachia through wild mosquito populations. An interdisciplinary investigation will develop a new data-driven mathematical modelling approach to predict Wolbachia dynamics under realistic conditions of environmental variability.

Keywords: v107 population dynamics,v305 ecology,v308 population biology - population dynamics - population genetics,mosquito-borne disease,wolbachia,aedes aegypti,biological control,mathematical model
Highly mismatched alloys to implement multiband solar cells (HIMAMIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-03-21
End date: 2015-10-29
Duration (months): 24.0
Total project cost (EUR): 230036.6
EU funding (EUR): 230036.6
Participants: 1
Project status: CLOSED

As it is well-known, it is a fact that one of the biggest problems that concern the current world is relative to the high energy consumption. This proposal is relative to the solar cell, in special with the third generation. This new generation of solar cells is created to obtain high efficiency and low cost conversion devices. Therefore, they are a potential component for the future. The proposal presents the know-how for the design, growth and improvement of the multiband solar cell. So far, this kind of solar cells are a specific topic of the Renewable Energies in the European Union Seventh Framework Program (FP7). However, despite a considerable effort of many research groups, there was no evidence of a working multiband photovoltaic device. Recently, the applicant, within a group at the Lawrence Berkeley National Laboratory in the USA, has designed, grown, tested and demonstrated the first multiband device, growing by dilute nitrogen, and being this concept the transfer technology relate to this proposal. Relying on the technological capabilities of the host institution, its deep knowledge on nanotechnology and its recent activities on new efficient solar cells, the new incorporated know-how will boost the activities of host institution to the topmost frontier of knowledge and development within the solar energy field.

Keywords: nanotechonoly,nanoscience,highly mismatched alloy materials,multiband materials.
Existence of Instabilities in Hamiltonian Systems on lattices and in Hamiltonian Partial differential equations (INSTAB12)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The study of Arnold diffusion in Hamiltonian systems has received a lot of attention in the last years. This phenomenon arises when a small perturbation in a system causes big changes in it leading to global instabilities. In recent years there have been partial results characterizing this phenomenon and proving its existence in Hamiltonian systems but mostly for systems of low dimension. This project wants to be a step forward showing that such instabilities also arise in Dynamical Systems on lattices and in Hamiltonian Partial Differential Equations (HPDEs), which can be seen as Dynamical Systems of infinite dimension. We will focus our attention on two different problems: the Fermi-Pasta-Ulam model and the energy transfer phenomenon in Hamiltonian PDEs. Regarding the first part, we will consider the Fermi-Pasta-Ulam model (FPU), which is a model of a discretized nonlinear string. One would expect that as time evolves, the system reaches equipartition of energy among the modes. Nevertheless, numerical experiments by Fermi, Pasta and Ulam (1955) showed that in some settings it is not reached in the time range for which the numerical experiments are reliable. This fact is called the FPU paradox. To understand how the equipartition of energy can be reached after longer times we plan to find instability mechanisms in the low energy regime. In the second part we will prove the existence of solutions of some HPDEs in the d dimensional torus which undergo transfer of energy to higher modes as time tends to infinity. This transfer of energy can be measured by the growth of high Sobolev norms. First, we plan to prove the existence of orbits with arbitrarily large finite growth of Sobolev norms for different Hamiltonian PDEs. Finally we plan to prove Bourgain's conjecture, which asserts the existence of orbits of the cubic defocusing nonlinear Schrodinger equation in the two torus whose s-Sobolev norms tend to infinity as time tends to infinity.

Keywords: hamiltonian sytems,nearly integrable systems,arnold diffusion,hamiltonian partial differential equations,transfer of energy
Deconstructing the stem cell niche in human interfollicular epidermis in vitro. (S.CE.N.E.)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Within adult tissues, stem cell properties are heavily influenced by their microenvironment, or niche. In the niche, stem cells integrate a complex array of extrinsic molecular signals that, in concert with cell-intrinsic regulatory networks, control self-renewal and differentiation in response to physiologic demands. By studying adult human epidermal stem cells ex vivo using artificial microenvironments (micro-patterned adhesive islands and hydrogels of differing bulk stiffness) we will investigate two questions: (1) What is the importance of intercellular adhesion in regulating epidermal stem cell fate? (2) How does the genetic state of a stem cell affect its responses to extrinsic signals? Combining state-of-the-art methodologies in biomaterials science and cell biology we will address whether cell-cell and cell-substrate signals have synergistic or antagonist effects on stem cell fate decisions, and whether one type of signal can over-ride another. Specific cell adhesion receptors will be engaged by recombinant proteins bound to latex beads, while specific cell-cell contacts will be engineered via avidin-biotin interaction. We will also investigate how intrinsic modulation of the Notch and Wnt signaling pathways changes epidermal stem cell responses to different niche signals of substrate contact area, substrate porosity and the engagement of specific intercellular adhesion receptors. The proposed project will be carried out at the Centre for Stem Cells & Regenerative Medicine, one of Europe's newest hot spots for stem cell research, based at King's College London, with Prof. Fiona Watt, a world expert in somatic stem cells, as scientist in charge. In such ideal surroundings, the fellow will be able to stimulate and advance European stem cell research, to significantly strengthen his own expertise in skin biology and to add novel research competences, and to establish his own network of collaborations in order to significantly advance his career development.

Keywords: l305 cell differentiation - physiology and dynamics,l312 stem cell biology,l307 cell signalling and cellular interactions
Experimental STation for the Analysis of the Spin dYnamics (EXSTASY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-06-03
End date: 2015-06-02
Duration (months): 24.0
Total project cost (EUR): 249242.8
EU funding (EUR): 249242.8
Participants: 1
Project status: CLOSED

The aim of the project is the development of an experimental station for performing experiments on the magnetic properties of materials thanks to the spin analysis of the photoelectrons. This goal will be achieved with the construction of a new UHV station that will be equipped with a vectorial mott detector apparatus already present at the TASC laboratory. The actual mott detector system will be implemented with new electronics and new acquisition software that will permit to perform time resolved experiments. The system will be designed to be fully compatible with the beamlines of the FERMI free electron laser. In this way we will obtain the first vectorial magnetometer with intrinsically high surface sensitivity, well adapted to nanostructures, capable of FEL-range time resolution. The measure of spin polarisation is intrinsecally unaffected by space-charge arising from high FEL intensity allowing the measure also in the extreme intensity conditions of the FEL source. The professor Petrov is a leading expert in the field of the spin analysis and will give an important contribution to the achievement of these goals.

Keywords: p205 electronic properties of materials and transport,spin resolved experiment,femtosecond time resolution,magnetization dynamics,free electron laser
Understanding the dynamics behind the photoisomerization of light-driven molecular rotary motors and switches (MOLMOTDYN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 223778.4
EU funding (EUR): 223778.4
Participants: 1
Project status: CLOSED

Light-driven molecular rotary motors derived from chiral overcrowded alkenes represent a central class of compounds for which photochemical rearrangements play a crucial role in their function. The mode of action of these motors is based on the periodic repetition of photo-isomerization and thermal relaxation steps, which lead to a uni-directional rotation of one part of the molecule (rotor) with respect to another (stator). A considerable increase in the rotation speed (ca. 10<sup>8</sup> times) has been achieved due to a lowering of the activation energy of the thermal helix inversion step. The photo-isomerization step however still remains poorly understood. It is the primary purpose of this project to fill this gap and to study the dynamics of photo-isomerization in light-driven rotary molecular motors. I will use excited state methods developed in my group to investigate the fluorene-based and phenanthrylidene-based molecular motors and assemblies of motor molecules. The theoretical study of the substituent effects and the hetero-atom effects on the properties of the ground and excited state potential energy surfaces, on the occurrence and position of conical intersections and avoided crossings and on the non-adiabatic couplings between the states will provide information necessary for designing new molecular motors. The effect of anchoring of the motor units on a substrate suitable for practical applications, such as surfaces of conducting or insulating materials, or (bio-)polymer substrates, on the mode of function of the motor will be theoretically investigated. In this regard, special attention will be paid to the possibility of increasing the power output by combining several molecular motor units within a single molecular device.

Keywords: photoisomerization,ultrafast dynamics of excited states,conical intersection,molecular motor,density functional calculations,strong non-dynamic electron correlation
Next-Generation Genetics of Axonopathies (HSP/CMT GENETICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-08-01
End date: 2016-07-31
Duration (months): 36.0
Total project cost (EUR): 263448.6
EU funding (EUR): 263448.6
Participants: 1
Project status: CLOSED

Development, maintenance and degeneration of neural processes is at the heart of a number of important neurodevelopmental and neurodegenerative diseases, including autism, Multiple Sclerosis, Alzheimer’s, and Parkinsons’s disease. Disturbances of such pathways come to a head in neurons developing and maintaining the longest axons in the nervous system. Studying axonopathies, diseases of the long axons of the nervous system, promises to understand key molecular pathways and vulnerabilities of axon health that eventually apply to all neuronal cells. To understand genetics and biology of axonopathies we will study two genetically highly heterogeneous Mendelian forms of axonopathies: Hereditary Spastic Paraplegias and Charcot-Marie-Tooth disease. Using next-generation sequencing technology we will identify novel genes causing these diseases. To this end we will produce 2.000 exomes on families with axonopathies over the next three years. In selected families the genetic analysis will be complemented by array CGH and whole genome sequencing. Novel candidate genes involved in axon degeneration will then be studied in a functional pipeline connecting several closely collaborating laboratories that use different model systems to study neurodegeneration: yeast, zebrafish, drosophila and cell culture models. Understanding the milestones of axon degeneration in these diseases holds the potential of tracing the way back to axonal function and integrity, therefore providing a chance of therapy for many so far incurable diseases.

Keywords: l511 neurological disorders,l101 molecular biology and interactions,l201 genomics - comparative genomics - functional genomics
Contentious Politics in an Age of Austerity: A comparative study of anti-austerity protests in Spain and Ireland (CPAA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-02
End date: 2015-09-01
Duration (months): 24.0
Total project cost (EUR): 254637.8
EU funding (EUR): 254637.8
Participants: 1
Project status: CLOSED

The proposed two year mobility involves undertaking research and training in the Department of Sociology at the National University of Ireland, Maynooth (NUIM), from the fellow’s current location at the University of Aberdeen, Scotland. Under the mentorship of Professor Seán Ó Riain, an expert in global political economy, the social aspects of the current financial crisis, and global ethnography, she will undertake a comparative study on anti-austerity mobilizations in Ireland and Spain to explain their widely divergent trajectories, thereby contributing important empirical knowledge while advancing major theoretical issues in contemporary research on contentious politics. The study will draw on the fellow’s expertise in European social movements to develop ongoing theoretical work on processes of transnational diffusion, movement latency, collective identity formation and use of ICTs in explaining the emergence and dynamics of social movement mobilization. The host department provides expertise in Irish politics, history, and comparative political research. The Department of Sociology at NUIM is Ireland’s leading centre for the study of social movements. The applicant will benefit from training and skills development in the areas of cross-national comparative methodology, and social movement practitioner focused pedagogy, both specializations of the host department. Public outreach activities include a series of public engagements with policy makers, civil society groups, students and the general public in the area of European contentious politics; a project website; and media engagement. The project will further the applicant’s career by enabling her to consolidate her leadership in the area of European social movements, and acquire methodological training, mentoring and experience in comparative political research. The research will contribute to a key area of concern for EU policy makers, scholars and practitioners and have measurable benefits for the ERA.

Keywords: s107,s105,s113,s109,s311,anti-austerity protests,european politics and society,financial crisis,comparative research,ireland,spain,collective identity,icts,movement culture
Monetized justice. The new meaning of penal fines in consumer societies (MONETIZED JUSTICE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-08-01
End date: 2014-08-31
Duration (months): 13.0
Total project cost (EUR): 121213.3
EU funding (EUR): 121213.3
Participants: 1
Project status: CLOSED

At the core of the project is the elaboration and presentation of one innovative concept: monetized justice. It aims to understand the social functions and consequences of the most important alternative to imprisonment in Western societies in times of the collapse of the Welfare state and the transformation of social control forms: the penal fine analysed within the most general context of financial penalties . In a monetized society, in which money is increasingly available and all objects can be exchanged for money, fine takes on a different meaning, which will be investigated in the context of this project, taking into account that fine is the only form of penal sanction where the burden need not be borne by the wrongdoer. In this respect, the concept monetized justice explores the view that contemporary penal governance is less concerned with disciplining individuals and more concerned with regulating distributions and flows of behaviours and the problems ands costs linked with these. To this end, the project will take an interdisciplinary approach between the doctrines for criminal justice, criminology and criminal policy, assigning a relevant role to sociology and offering a multidisciplinary perspective.

Keywords: criminal law,penal fine,consumer societies,monetized justice,criminal liability of corporations,governmentality