Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ADAPTIVE OPTICAL METASURFACES FOR REAL-TIME, LABEL-FREE AND NON-DESTRUCTIVE 7D DIGITAL PATHOLOGY (OPTIPATH)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway,Denmark,Finland,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 3276577.5
EU funding (EUR): 3276577.5
Participants: 7
Project status: SIGNED

Treatment decisions for many pathological conditions, including inflammatory, degenerative, autoimmune, infectious diseases, and cancer, are largely based on microscopy study of the surgically excised tissue specimens (histology). OPTIPATH provides a new paradigm for gathering objective optical tissue-dependent data, which is essential to overcoming the diagnostic challenges of inter-observer variability and limited sensitivity and specificity. OPTIPATH will offer non-destructive, label-free, real-time, 3D-presentation of tissue samples. This is enabled by (i) revolutionary nano-photonic optical metasurfaces (OMS) for simultaneous single-shot acquisition of spectral and polarimetric information, and adaptive OMS actuated by thin-film piezoelectric Micro-Electro-Mechanical-Systems (MEMS) for (ii) rapid Vector Vortex Beam (VVB) shaping of light, and (iii) rapid confocal 3D imaging. The wealth of objective diagnostic data provided will be interpreted using Machine Learning (ML) / Deep Learning (DL), and is essential to overcome inter-observer variability in diagnosis and provide actionable insights to the clinician. By utilizing optical markers present in unprepared tissue histological procedures can be dramatically sped up, offering real-time diagnosis in operation theatres and pathology departments. By offering timely and accurate diagnosis, OPTIPATH will enable early diagnosis and improved prognosis of recovery.

Keywords: histopathology,photonics,nonaphotonics,metasurfaces,mems
Evolving increased vertebral counts: Developmental mechanisms underpinning phenotypic evolution in the Lake Malawi cichlid radiation. (COUNTS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1906138.01
EU funding (EUR): 1906138.0
Participants: 1
Project status: SIGNED

One of the fundamental and most longstanding questions in biology is how phenotypes evolve to generate the incredible diversity of forms that surround us in the natural world. Vertebrate body shape is a good example of this, with species’ forms ranging from the rounded ocean sunfish to elongated snakes, and everything in between. The evolution of vertebrate body shapes has been accompanied by significant variation to the axial skeleton and the vertebrae that compose it, which can vary in size and morphology, but crucially also in number, ranging from less than 10 to several hundred. In COUNTS I propose an inter-disciplinary approach to uncover the developmental drivers of phenotypic diversity in vertebrates by using Lake Malawi cichlid fishes as a model system to investigate the evolution of increased vertebral counts. The diverse morphology, conserved genomes, close-relatedness, and ability to hybridise of these fishes makes them the ideal system in which to study how the evolutionary modification of developmental mechanisms has led to phenotypic diversity, in this case by evolving increased vertebral counts. The COUNTS project will combine state-of-the-art experimental embryology, single cell technologies, microscopy, and mathematical modelling to ask how developmental processes differ in three Lake Malawi cichlid species that have convergently evolved increased vertebral counts, and two that retain ancestral numbers. Specifically, we will characterise differences in two developmental processes known to play important roles determining total vertebral counts - gastrulation and somitogenesis - and use data-driven mathematical modelling to ask how these differences might have evolved. COUNTS will increase our fundamental understanding of how phenotypic diversity is generated, informing how phenotypes might evolve when faced with a rapidly changing climate and potentially contributing to practical applications such as organoid design for regenerative medicine.

Keywords: evodevo,emergent model systems,data driven mathematical models,next gen comparative embryology
The Gentrification of Activism, Autonomous Collective Politics and the Right to the City in Exarchia, Athens (GAPRIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 153486.72
EU funding (EUR): 153486.72
Participants: 1
Project status: CLOSED

GAPRIA aims to examine the gentrification of activism, which entails the ways radical activist neighbourhoods become gentrified leading to the eviction of emancipatory visions about city life. Although gentrification and eviction studies have thoroughly documented the social and material costs of gentrification policies on the urban poor, they have failed to document their political costs relating to the eviction of communities of activists that produce more emancipatory visions about city life. GAPRIA will fill this gap by examining such questions in the urban neighbourhood of Exarchia in Athens, Greece that has a long history of anti-authoritarian and direct democratic struggles. GAPRIA will examine the gentrification of activism along 4 levels of enquiry: (1) The conceptual level, whereby activists produce emancipatory ideas about city life. (2) The discursive level whereby GAPRIA will aim to substantiate the emerging concept of ‘evictability’ by exploring, through policy and media analysis how certain subjects are produced as evictable. (3) The level of praxis, whereby through ethnographic fieldwork with activists and residents, resistance to gentrification will be documented. (4) The comparative level, whereby the gentrification of activism will be explored in an inter-disciplinary manner through the organization of an International Conference engaging scholars from Anthropology, Urban Studies, Politics and Human Geography. GAPRIA will deliver a monograph, a Special Issue and a peer-reviewed journal article. Actions for networking and knowledge transfer include a website, a policy brief, a community event, a short film, the organization of an International Conference and a proposal for a European Research Council Starting Grant. Results will contribute directly to transnational debates on the costs of urban regeneration policies, their interconnection with recent attacks on autonomous activism and the worldwide rise of the Far Right.

Keywords: gentrification,activism,eviction,biopolitics,youth,antiauthoritarianism,resistance,public space,regeneration,direct democracy,horizontal politics
Nanostructure formation during food protein digestion and influence on intestinal transport (PRODIGEST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2355741.0
EU funding (EUR): 2355741.0
Participants: 1
Project status: SIGNED

The global food system is currently facing great challenges, which are mainly motivated by environmental and health-related concerns: (i) The existing food resources are not efficiently utilized; while some of them are overexploited, causing water/soil shortage, biodiversity losses, etc., others are not properly valorized (e.g. seaweeds). (ii) Moreover, the unhealthy dietary habits of modern societies are leading to a dramatic increase in the incidence of diet-related chronic diseases (e.g. obesity, diabetes, etc.). In this context, the food industry is actively looking for ‘novel’ food sources with added health benefits. However, to design strategies for a sustainable production of nutritious food products from alternative sources and to predict their potential metabolic responses (e.g. satiety, allergenicity, etc.), it is essential to understand how food structure, digestibility and bioavailability are correlated. PRODIGEST seeks to investigate this topic from a novel perspective, focusing on the mechanistic and structural aspects of the gastrointestinal digestion of food proteins and studying their implications on bioavailability. The type of structures formed by the assembly of the digestion products through intermolecular associations or by interactions with physiological medium components, as well as the effect of dietary fibres (which are abundant in alternative protein sources) will be studied and linked to their intestinal transport and susceptibility to trigger metabolic responses. To address this challenge, a set of advanced structural characterization tools (including X-ray and neutron scattering techniques, peptidomic analyses and rheology), as well as intestinal transport studies, will be combined through a multi-disciplinary approach, interconnecting structural characterization, food science and biotechnology. The project outcomes will find potential applications to diverse research areas, such as nutrition, food technology, pharmacology and medicine.

Keywords: digestion,proteins,dietary fibres,scattering,x rays,multi scale structure,novel foods,bioavailability
PHOtoactivated Metal Oxide TRansport layers for Indoor Perovskite Photovoltaics (PHOMOTRIPP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Harnessing indoor lighting available in buildings has the potential to power the next generation of Internet of Things, creating a more environmentally and economically sustainable ecosystem to accelerate future innovation. Indoor photovoltaics enable this by utilising artificial light sources such as white light-emitting diode and fluorescent lamps to negate the limitations imposed by battery-powered systems. Among the emerging photovoltaic technologies, indoor perovskite solar cells display immense promise and require further study to reach their true potential. The electron transport layer, an integral part of the perovskite solar cell architecture, is of particular interest as its optimisation can lead to overall enhancement of device performance in indoor conditions. Popular metal oxide-based electron transport layers, that offer solution processability, tunable electronic properties, high carrier mobility, and favourable energy level match with the perovskite, continue to suffer from high temperature processing and interfacial defects. Lowering the processing temperature to increase compatibility with flexible devices, diversifying the metal oxide family to develop a wider choice of materials, and formation of metal oxide composites to augment charge transfer and stability, are some measures that can overcome the challenges of the present transport layers and further enhance their properties. This study attempts to achieve this by innovatively combining low temperature photo-annealing and graphene incorporation to produce high quality films of conventional and novel metal oxides, that can be employed in indoor perovskite solar cells to improve overall device efficiency and stability. This proposal is a focussed but significant attempt to fill the gap arising from a lack of concentrated study on electron transport materials, more specifically inorganic metal oxides in the domain of indoor perovskite solar cells.

Keywords: electron transport materials,metal oxide,graphene composite,sol gel,photo annealing,indoor perovskite solar cell,flexible photovoltaics,energy harvesting
Exploring Transnational Challenges: Climate Change, Migration, and Energy Insecurity in the Mediterranean (TRACHMED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Türkiye,Germany,Ireland,Portugal,Lebanon,Algeria,Morocco,Greece,France,Italy,Spain
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 1150000.0
EU funding (EUR): 1150000.0
Participants: 12
Project status: SIGNED

Transnational challenges are pressing issues in any region. They transcend national borders and defy unilateral remedies. Multilateral efforts and capacity building remain fragmented. Regional efforts rarely bear fruit. As a result, despite two-decades of effort, transnational challenges cannot be understood and responded effectively. There has already been a growing call to rethink the existing approaches arguing for the need to understand the nature and scope of transnational challenges better, why the existing approaches and frameworks for cooperation, collaboration, and coordination do not work, and how they can be responded. Transnational challenges hit the Mediterranean particularly hard. Unilateral, multilateral, and regional responses to them in the region remain fragmented and ineffective. TRACHMED is a research and staff exchange programme intended to contribute to the global, regional, and national efforts of understanding and responding transnational challenges by conducting research in Mediterranean on three such issues: climate change, migration and forced displacement, and energy insecurity. It brings together an international, intersectoral, and interdisciplinary research team to 1) collect, interpret and process original empirical data on selected transnational challenges with a transnational perspective, 2) engage with the existing conceptual and theoretical debates and contribute to the conceptual and methodological approaches for studying, comprehending, and responding to transnational challenges, 3) develop and sustain a transnational network of researchers, practitioners, and institutions in the Mediterranean, thus increase the research capacity and shared knowledge and cooperation, 4) update scientific knowledge on these issues for relevant EU policies, political and economic actors interested or already working in the region, and to inform international organizations and decision-makers in the region.

Keywords: transnationality,challenges,migration,energy insecurity,climate change,mediterranean
PERmanent MAgnet Network for the European Transition (PERMANET)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Spain,Italy,France,Türkiye,Germany,Slovakia,Slovenia,Austria,Romania,Belgium,United Kingdom,Greece,Portugal
Call: Rare Earth and magnets innovation hubs (IA) (HORIZON-CL4-2024-RESILIENCE-01, 2024)
Start date: 2024-10-01
End date: 2028-01-31
Duration (months): 40.0
Total project cost (EUR): 20819760.5
EU funding (EUR): 15998160.38
Participants: 34
Project status: SIGNED

PERMANET is a Sustainable REE Innovation and Supply Network covering the full Rare Earth Elements (REE) Permanent Magnet (PM) value chain. It is structured upon 5 layers: 1) Three Sustainable, Connected Tech ‘Hubs’ segmented along the full REE PM value chain and organizing thematic collaborative R&D and supply ecosystems 2) 13 fully Scalable Innovations to reach TRL7 and expand in scale and deployment range along the entire value chain 3) A structural layer of R&D infrastructure, equipment and services to fuel Pilot and Demonstration activities 4) Five Enabling “Engines” addressing the key conditions for sustainable and competitive REE supply 5) All embedded within a single PERMANET Network Infrastructure with its own, sustainable organizational model. The Network accelerates leading-edge innovations, from REE extraction from mining tailings and hydrometallurgical processes to oxide reduction and innovative production processes, all the way to the production of innovative PM and their testing by end users in industrial environment across 1/ E-Mobility 2/ Energy 3/ Industrial Equipment. PERMANET also secures key sources of REE such as leading mining projects from the EU and Partner Countries, as well as End of Life (EoL) sectors (WEEE, EV, etc.). The project relies on enabling activities ranging from strategic venturing to investment support to build sub-optimal EU REE PM Segments. The project unlocks viable reserves of REE including unconventional sources and will demonstrate novel, cost-effective, and environmentally sound REE extraction, processing, and separation routes, as well as demonstrate the first EU hub for PM boosting circular PM technologies to deploy at market scale. The project is ready to be fully integrated with other EU-backed PM Hubs and aims to grow into a fully-fledged Pan-EU pilot and demonstration infrastructure to remain sustainable post-funding.

Keywords: permanent magnets,recycling,tailings,sustainable mining,neodynium,weee,hydrometallurgy,oxide reduction,investment,end of life,regions,industrialisation,network,pilot and demonstration
Evaluating linkages between phytoplankton community structure and carbon export using BGC-Argo floats (PHY-GO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

Marine phytoplankton are a primary vector in the transport of carbon dioxide from the atmosphere to the ocean interior via the biological carbon pump. The magnitude and efficiency of this flux hinges on phytoplankton community structure—the relative abundance of different phytoplankton groups present within a given water mass. Therefore, accurate estimates of phytoplankton community structure are crucial for understanding global carbon cycles and for anticipating the impact of global climate change. Phytoplankton distributions within the global ocean are typically inferred from bio-optical proxies reflecting phytoplankton physiology (e.g., chlorophyll fluorescence) or concentrations of particulate carbon (e.g., attenuation coefficients or optical backscatter coefficients). The deployment of biogeochemical Argo (BGC-Argo) autonomous profiling floats is transforming the global coverage of these measurements, providing new insight into connections between phytoplankton distributions and export processes. However, few studies have evaluated relationships between bio-optical proxies as measured by BGC-Argo floats and direct measurements of phytoplankton community structure, and none have performed an intercomparison of these relationships across different ocean basins. Therefore, I propose to 1) utilize a combination of novel and existing flow cytometry methods to estimate group-specific phytoplankton biomass across four disparate ocean provinces, 2) evaluate the bio-optical proxies that best predict group-specific phytoplankton biomass within each province, 3) leverage relationships identified in objective 2 to develop a novel transfer function for estimating phytoplankton biomass based on bio-optical proxies alone, and 4) apply this function to existing BGC-Argo data to quantify the importance of variability in phytoplankton community structure to carbon export to the mesopelagic zone, as compared to other mechanisms.

Keywords: phytoplankton ecology marine bio optics autonomous platforms flow cytometry chlorophyll carbon cycl
Automatic vein wall disruption, triggering the body’s natural cellular healing response to close targeted veins curing Venous Leg Ulcers (EnVena)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 3611770.0
EU funding (EUR): 2497614.0
Participants: 1
Project status: CLOSED

Chronic venous disease is one of the most common diseases in the developed world, affecting up to 60% of adults over the age of 50. Chronic venous disease is the leading cause of Venous Leg Ulcers which are chronic open sores, usually on the inside of the leg that will not heal without specialist treatment. The total costs associated with managing venous disease patients across Europe and the US is €33.4 billion per year, representing 2.5% of total healthcare expenditure. Most patients are treated with ineffective compression bandaging which does not treat the underlying cause and has an unacceptably high recurrence rate. These bandages are also sent to landfill with a high environmental impact EnVena is the world’s first device to mimic the body’s natural healing response to deliver an effective treatment to venous leg ulcer patients.

Keywords: arterial emboilisation,healthcare,biotechnology,catheter technologies,micro system engineering,micro machining,venous leg ulcers,bleeding disorders,tumour embolisation,liver cancer,medical devices,health related biotechnology