Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ascertaining Barriers for Compliance: policies for safe, effective and cost-effective use of medicines in Europe (ABC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Poland,United Kingdom,United Kingdom,United Kingdom,Belgium,Switzerland
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2012-06-30
Duration (months): 42.0
Total project cost (EUR): 2919113.0
EU funding (EUR): 2235023.0
Participants: 6
Project status: CLOSED

Medication non-compliance is highly prevalent across all medical conditions, and represents a major barrier for realising the benefits of evidence-based therapies. The aim of the project is to produce evidence-based policy recommendations for improving patient compliance and subsequent better use of medicines by Europeans. Lack of consensus in the terminology used in this field impedes benchmarking of compliance-enhancing interventions. Therefore the first stage of the project will be to build a pan-European consensus on terminology and taxonomy of non-compliance. Effective interventions in this field should take into account the differences that exist between determinants of compliance with short-term and chronic treatments, and for different clinical sectors, health care settings and population segments. Therefore, not only will the determinants of patient compliance be identified in a systematic review of the literature, but also a survey across 16 European countries, and discrete choice experiment will be conducted. Then, a conceptual framework for the influential factors of non-compliance will be developed. Current practices of compliance management by healthcare professionals and the pharmaceutical industry will be compared across Europe, as well as educational programs from schools of medicine and pharmacy. Compliance-enhancing interventions will be compared in terms of practicality, clinical- and cost-effectiveness. The information gathered will be integrated, and priorities made to inform policy recommendations on strategies to improve patient compliance. The project findings will be discussed extensively with European experts, and based to the consensus obtained, the final recommendations will be formulated and presented to the European Commission and other relevant stakeholders. To enable widespread dissemination of the project results, they will be made available to the public as conference presentations, scientific publications and Web material.

Keywords: compliance,adherence,concordance,medication,policy recommendation,public health,better use of medication
Assessing Needs of Care In European Nations (ANCIEN)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Belgium,Germany,Netherlands,Spain,Italy,Austria,United Kingdom,Poland,Slovenia,Hungary,Finland,France,Sweden,Slovakia,Estonia,Netherlands
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2012-10-31
Duration (months): 46.0
Total project cost (EUR): 3516921.2
EU funding (EUR): 2712777.0
Participants: 20
Project status: CLOSED

The large post-war baby boom is now turning into a grandparent boom, putting a triple stress on long-term care (LTC) provisions: increased numbers of elderly, increased survival of these elderly and increased survival of frail, disabled elderly through improved care and health care. Increasing body weights, through increasing disability and care dependence among the obese, further add to numbers of disabled elderly. The supply of labour is affected by the ageing of the EU population. Consequently, increasing emphasis has been put on the future development of long-term care needs, supply and use, and the functioning of LTC systems. The objectives of ANCIEN (Assessing Needs for Care In European Nations) are to review the LTC systems in EU member states, to assess the actual and future numbers of elderly care-dependent people in selected countries and to develop a methodology for comprehensive analysis of actual and future LTC needs and provisions across European countries, including the potential role of technology and policies on maintaining and improving quality. Performance indicators will be identified and relative performances of the different types of LTC systems assessed. Databases of EU countries are constructed, containing available data on LTC needs and use of the elderly. Participating partners from different countries cover the majority of the EU member states. State of the art demographic, epidemiologic and econometric models are used to project future needs and use of long-term care in representative member states with different LTC systems. Deliverables contain databases, dynamic models calculating long-term care needs, reports on future needs and use of LTC in representative member states, and country-specific and general reports on LTC systems and their performance.

Keywords: long-term care,organization and financing long-term care,projection of needs for long term care,long-term care systems
Promotion of plasticity as a treatment for neurodegenerative conditions (PLASTICISE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Switzerland,Italy,Netherlands,United Kingdom,Germany,Poland,Germany,France,Israel,United Kingdom
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-12-01
End date: 2012-11-30
Duration (months): 48.0
Total project cost (EUR): 6767728.31
EU funding (EUR): 5199445.0
Participants: 16
Project status: CLOSED

Neurodegenerative diseases all cause damage to the circuitry of the nervous system, with loss of connections, axons and neurons. The loss can be gradual, as in Alzheimer’s disease, rapid as in stroke, or intermediate as in the delayed neuronal loss after stroke. Following damage, the nervous system is able partially to compensate through the formation of alternative connections and pathways, a process known as plasticity. Adults are therefore able to regain considerable function after stroke, and to compensate for the synapse and cell loss of Alzheimer’s disease until it reaches a critical level. Children undergo a period of enhanced plasticity in most parts of the CNS at the end of development, known as critical periods. During these periods their ability to compensate for damage to the CNS is in many cases much greater than in adults. The overall concept behind this application is that restoration of the function in neurodegeneration can be achieved through plasticity (the formation of new functional connections, withdrawal of inappropriate connections, modulation of synaptic strength). Promoting increased plasticity in selected parts of the adult nervous system back to the level seen in children is a powerful method of enhancing recovery of function in animal models. Plasticity-promoting treatments could therefore be beneficial in a wide range of conditions that damage the CNS. The PLASTICISE project integrates scientists from four scientific areas 1) Development of methods to promote plasticity 2) Development of models of neurodegenerative disease 3) Imaging of plasticity at the macro and micro level 4) Study of recovery of function through plasticity in human patients with brain disorders. The concept that unites the partners is the belief that treatments that enhance plasticity will become one of key medications that will improve neurological function in the damaged human nervous system. The purpose of the project is to bring this moment closer.

Keywords: plasticity,new animal models,macro/micro imaging,recovery of function
Black Sea Interconnection (BSI)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Türkiye,Greece,United Kingdom,Georgia,Azerbaijan,Armenia,Austria
Call:  (FP7-INFRASTRUCTURES-2007-2, 2007)
Start date: 2008-03-01
End date: 2010-02-28
Duration (months): 33.0
Total project cost (EUR): 1861908.0
EU funding (EUR): 1400000.0
Participants: 7
Project status: CLOSED

The South Caucasus countries, Armenia, Azerbaijan and Georgia are linked to the pan European research backbone GEANT with only limited capacities which constitutes a major blocking factor to consolidate the potential of the region and to establish stronger links with the scientific community of the EU. The establishment of high speed connections between the South Caucasus countries and to GEANT will both introduce new technologies and services to the Information Society in those countries and be an important step towards the integration of those countries’ scientific potential to the European infrastructure. The Black Sea Interconnection (BSI) project with the participation of ULAKBIM, GRNET, CEENET,DANTE, GRENA, AZRENA and Academia of Science aims to setup and operate such a network among South Caucasus countries. A number of projects funded by EC and NATO have contributed to the development of e-Societies and the networking infrastructure in the region. These projects served the dissemination of research networking knowledge and constitution of regional Information Society by creating a human network in the region. Besides, the limited connection capacities among the NRENs and to GEANT harden the consolidation of regional scientific potential and they are inadequate for involving in scientific strategies and working groups of GEANT project. The BSI project intends bridging the digital divide that exists between the South Caucasus countries and Europe by establishing a regional research and education network in the region and connecting it to GEANT. Project involves development of strategies for interconnecting the existing infrastructures in the region, realization of the connections and supplying operational support for the established network. In addition, BSI will contribute to the integration of South Caucasus scientific potential to Europe by successfully disseminating the infrastructure and promoting the IST projects in South Caucasus countries

Keywords: black sea interconnection south caucasus geant connection
Poverty related Diseases College(International Programme on BioMedicine and Development) (PRD COLLEGE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Coordination and support actions
Countries involved: Cameroon,Sweden,Netherlands,Italy,Italy,Uganda,Germany,Zambia,Tanzania, United Republic of,Germany
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-07-01
End date: 2013-03-31
Duration (months): 45.0
Total project cost (EUR): 1669999.0
EU funding (EUR): 1408012.0
Participants: 10
Project status: CLOSED

To bridge the gap between the biological sciences, health and development in Africa, a consortium is created and named the PRD College, which proposes to reorganise and educate young African and European scientists to perform research, on poverty related and neglected diseases (PR&ND) that is relevant to development. These diseases are common ground for both the African nations who wish to develop and the European Union who wishes to contribute to and collaborate with Africa for development. Experiences with members of this consortium on the Multilateral Initiative on Malaria (MIM) that was begun by the TDR of World Health Organisation and subsequently the Gates Malaria Partnership of the London School of Hygiene and Tropical Medicine and recently with the EU funded Network of Excellence (BioMALPAR) post-doctoral programmes, confirmed that scientific capacity building in Africa is beneficial for both disease control as well as for national development, but that the scientific sector in Africa cannot yet stand on its own feet and needs to be enhanced and directed towards development in order to be sustainable. The PRD College will stimulate an early collaboration and enable young scientists to place science within the context of development in Africa. Certain capacity areas will be given focus through elective and mandatory courses followed by an internship in development at an African institution and a science exchange program. Divided into a 6 work packages and 4 committees, training capacity will be strengthened at 3 PRD Centres in Uganda, South Africa and Cameroon and involve MDs, advanced PhD Students or Post-Docs participants from Africa (12) and Europe (12). The PRD College will transform every trainee scientist to a level where participants can become trainers in their own country, using the oil-stain effect principle to spread knowledge and this new approach.

Keywords: poverty,infectious diseases,biosciences,development,science exchange,african institutions internship.
“The International Data Coordination Centre” (I-DCC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Coordination and support actions
Countries involved: United Kingdom,Germany,Italy,Germany,Greece,United States,Canada,United Kingdom,United Kingdom
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2013-09-30
Duration (months): 57.0
Total project cost (EUR): 3585680.1
EU funding (EUR): 2683509.0
Participants: 10
Project status: CLOSED

The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis programs have been established worldwide with the aim of creating loss-of-function mutations in all genes in the mouse. At the moment, these resources largely consist of frozen archives of genetically modified mouse embryonic stem cells that can be conveniently disseminated within the international mouse genetics community for the purpose of generating knockout mice. Most notably, the EUCOMM, KOMP and NorCOMM projects (based in Europe, the USA and Canada, respectively) have been recently established and are expected to achieve near-complete coverage of all mouse genes using high-throughput gene trapping and gene targeting technology. Currently, there is no single point of entry for information on the international ES cell resources. The overall goal of theI-DCC is to lead an effort to establish common data formats and a single portal for access to information on all mutant ES cell resources. This project is built on exceptionally strong international expertise in mouse genome informatics and includes key scientists and bioinformaticians actively involved in the three ongoing large-scale mouse knock out projects (EUCOMM, KOMP and NorCOMM). The I-DCC will 1) coordinate with existing international bioinformatics resources to catalogue and assign unique identifiers to all mouse genes, 2) collaborate with all major ES cell production sites to define standard data formats for the annotation and display of mutant alleles and 3) provide ES cell repositories with standardized data on all ES cell lines and 4) establish a common web portal to facilitate the distribution and use

Keywords: mouse,genetic,resources,mutagenesis,es cells,achieve,access,information,bioinformatics,web portal,common
e-Infrastructures Reflection Group Support Programme 2 (E-IRGSP2)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Finland,United Kingdom,Portugal,Greece,Netherlands,Poland,Netherlands
Call:  (FP7-INFRASTRUCTURES-2007-2, 2007)
Start date: 2008-01-01
End date: 2010-12-31
Duration (months): 36.0
Total project cost (EUR): 1649468.0
EU funding (EUR): 1150000.0
Participants: 8
Project status: CLOSED

The e-Infrastructures Reflection Group Support Programme 2 (e-IRGSP2) project provides full support to the work of the e-Infrastructures Reflection Group (e-IRG). The e-IRG has been instrumental in the development of the policies and documenting the best practices, producing five white papers and a roadmap presenting the consensus of the leading European Grid and networking infrastructure experts. The e-IRGSP2 uses the experiences of the previous support action (e-IRGSP), combined with an in-depth analysis of the evolution of the e-IRG itself, to plan for an optimal support strategy. The activities of the project are based on supporting the process of the e-IRG, modelled as an iterative repetition of four phases: (1) Studying the state-of-the-art and best practices, (2) Creating scenarios based on the data (white papers and roadmaps), (3) Establishing consensus about the actions needed (e-IRG recommendations) and (4) Engaging with the necessary stakeholders. The support is based on three services: Secretarial support, which is involved in all of the activities. Its role is central in enabling e-IRG to study the state-of-the-art and engage with the necessary stakeholder groups through communication and dissemination support. Support for the policy activities provides rapid analysis of the impact of the developments on relevant levels (policy, technical, usage patterns) of e-IRG goals. The activity takes the input generated in the phase 1 through the next two steps. Liaisons with research and other stakeholders focuses on identifying the key activities, developments and trends emerging in the world surrounding e-IRG. It facilitates dialogue about the interplay between the opportunities, goals and gaps related to the e-IRG vision and the surrounding legal, technical and socioeconomic framework. In phases 4 and 1 this ensures that the next iteration of the process will receive sufficient input.

Keywords: grid computing,policy support,e-infrastructure,inter-governmental organisations,analysis,foresight studies
Population biology and molecular genetics of vectorial capacity in Anopheles gambiae: targeting reproductive behaviour and immunity for transmission-refractory interventions (MALVECBLOK)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: France,Netherlands,Italy,France,Mali,Kenya
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2012-06-30
Duration (months): 42.0
Total project cost (EUR): 3007746.4
EU funding (EUR): 2302500.0
Participants: 7
Project status: CLOSED

Malaria, one of the world’s most devastating diseases, is caused by protozoan parasites of the genus Plasmodium and is obligatory transmitted to humans by anopheline mosquitoes. The African mosquito species Anopheles gambiae s.s., is the major vector of this disease. Research groups from 3 European countries and 3 African teams will integrate their resources and scientific expertise in malaria research to expand knowledge of mosquito biology and of vector-parasite interactions, exploiting the opportunities provided by the recently available genome information and technological developments for mosquito vectors. The joint scientific program of the MALVECBLOK Consortium integrates for the first time three crucial aspects of biology of An. gambiae: reproduction, immunity and population biology, with the aim to ultimately provide novel concepts and targets for malaria control. The main objectives will address: (i) The molecular bases of reproductive biology of the mosquito vector, and its effects on immunity and Plasmodium transmission; (ii) The molecular mechanisms which determine the mosquito immune status and regulate Plasmodium sporogony and transmission, in both laboratory settings and natural populations; (iii) The role of genetic polymorphism in genes controlling reproduction and immunity on structure of mosquito populations and malaria transmission in Africa. In order to reach these objectives, MALVECBLOK will employ a number of concerted strategies in support of its 3-year agenda. Special attention will be given to cutting-edge training opportunities and sharing of resources, by implementing interactive programmes for the training and exchange of personnel at all levels, and by rationalising and coordinating investment. The innovative knowledge generated under this trans-disciplinary project will promote European scientific competitiveness and will impact global health issues.

Keywords: malaria,mosquito vector,reproduction behaviour,host-parasite interactions,immunity,population biology
ASSESSING THE OVER-THE-COUNTER MEDICATIONS IN PRIMARY CARE AND TRANSLATING THE THEORY OF PLANNED BEHAVIOUR INTO INTERVENTIONS (OTC SOCIOMED)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Greece,Sweden,Netherlands,France,Malta,Czechia,Cyprus,Türkiye,Greece,Virgin Islands, British,Netherlands
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-12-01
End date: 2012-05-31
Duration (months): 30.0
Total project cost (EUR): 1289600.0
EU funding (EUR): 967185.0
Participants: 12
Project status: CLOSED

The inappropriate supply and consumption of non-prescribed medicines consists a public health problem of outmost importance for developed as well as for developing countries. The aims to develop new research methods and generate scientific basis to reduce the incidence of drug-related mishaps and maximize the potent effect of medicines in the provision of healthcare. The project utilizes a theory-specific approach to identify and understand primary care physicians’ and primary care patients’ behaviour towards prescription and consumption of medicines. Grounded on the theory of planned behaviour (TPB; Ajzen, 1991) seeks to identify predisposing behavioural factors that will enable the alteration of the problematic behaviour. This model also provides the basis for theory-guided interventions, tailored to address the behavioural components playing an influential role in the irrational prescription and consumption of medicines. In particular, the project’s objectives include the assessment of the extent of OTC misuse in countries of southern Europe, the identification of influential factors on primary care physicians and patients’ intentions towards irrational prescription and misuse of medicines as well as the design and implementation of certain pilot interventions with the potential to be translated into policy. Qualitative and quantitative research methods will be employed to assess predisposing factors of inappropriate prescription practices and medicine misuse in samples of primary care physicians and primary care patients. Pilot interventions will be also devised and applied. Southern European countries will benefit from the progress and the know-how of northern European countries invited to participate in the current proposal. Another benefit will be the formation of a network consisting of various disciplines that ensures evaluation, discussion and widespread dissemination of emerging knowledge throughout European primary health care settings.