Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Marine Systems Approaches for Biodiversity Resilience and Ecosystem Sustainablity (Marine SABRES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Ireland,Spain,Faroe Islands,Netherlands,Italy,Lithuania,Denmark,Portugal,United Kingdom,Germany,Iceland
Call: Demonstration of measures and management for coastal and marine ecosystems restoration and resilience in simplified socio-ecological systems. (HORIZON-CL6-2021-BIODIV-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 8755388.75
EU funding (EUR): 8755388.75
Participants: 25
Project status: SIGNED

Marine Biodiversity loss is continuing to decline despite current conservation efforts. Reversing the decline in biodiversity requires rapid roll out of effective conservation measures that can also enable a sustainable and resilient blue economy. Social-ecological systems-thinking and Ecosystem-Based Management are globally recognized tools to enable balanced marine development and conservation. Marine SABRES will co-design as Simple Social Ecological Systems approach (the Simple SES) to rapidly enable and upscale EBM across Europe and abroad. Marine SABRES will set European marine management on a course to reverse biodiversity decline, it will conserve and protect biodiversity by integrating sustainable ecosystems and a resilient blue economy; enable managers to make sustainable decisions; empower citizens to engage with marine biodiversity conservation; promote sustainable development and in coastal and marine sectors. Marine SABRES is comprised of an interdisciplinary consortium including world leaders in the field of EBM and Social Ecological System distributed across Europe and focusing demonstration of practical management efforts in three Demonstration Areas (Tuscan Archipelago, the Arctic North-East Atlantic and Macaronesia) before upscaling throughout Europe and beyond.
advancing Hydrogen (H2) technologies and smart production systems TO decarbonise the GLass and Aluminium SectorS (H2GLASS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Norway,Italy,Germany,United Kingdom,Slovenia,Spain,Belgium,France
Call: Integration of hydrogen for replacing fossil fuels in industrial applications (Processes4Planet Partnership) (IA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 31862996.25
EU funding (EUR): 23267442.0
Participants: 23
Project status: SIGNED

The glass industry will have to be completely decarbonized in the next 30 years. The lifetime of a glass furnace is about. 12-15 years. So it is urgent to start innovating because the year 2050 is only 2 furnaces away. H2GLASS aims to create the technology stack that glass manufacturers need to (a) realize 100% H2 combustion in their production facilities, (b) ensure the required product quality, and (c) manage this safely. H2GLASS will address the challenges related to NOx emissions and high flame propagation speed, process efficiency, and supply of H2 for on-site demonstrations. Digital Twin techniques will be critical for risk-based predictive maintenance, optimized production control, and combustion system control. Hydrogen will be supplied by a portable electrolyser co-funded by the industrial demonstrators, and the oxygen produced will be reused in the process. The H2GLASS technologies and design solutions will be validated up to TRL 7 on 5 industrial demonstrators from 3 segments (container glass, flat glass and glass fibre), which together represent 98% of the current glass production in the EU. The expertise of partners such as Steklarna Hrastnik, PTML Pilkington, Owens Corning and Stara Glass representing the State Of The Art (SOTA) in the use of H2 in the glass process will be an asset for the H2GLASS Consortium. A demonstrator for the aluminum industry (HYDRO) will prove the transferability of the basic solutions and underlying models to energy-intensive industries that have similarities with the glass manufacturing process, thus strengthening the impact of the project. In EU the Glass and Aluminium industries employ >400.000 people in Europe, generate > 3.5B€ and emit ca.21.5 Mt CO2e. The innovations generated by H2GLASS will potentially create 10.000 new jobs and unlock 1 - 5B€ revenues for glass technology deployment, >17B investments and 200.000 new jobs for green H2, and cut emissions by ca.80%.

Keywords: hydrogen,digital twin,smart production,energy intensive industry
A Multimodal Framework for Body-Brain Dynamics in Health and Disease (DYNABODY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 1498820.0
EU funding (EUR): 1498820.0
Participants: 1
Project status: SIGNED

Rhythmic peripheral signals like respiratory, cardiac, and gastric activity not only serve our bodies’ strive for homeostasis, but actively modulate brain activity and behaviour. However, what are the functional mechanisms and signalling pathways by which these rhythms orchestrate brain function? An ever-growing number of studies show that body-brain interactions are of prime importance when we assign functional roles to brain activity. Yet, little is known about how body-brain coupling is governed by states of the body (e.g. breathing interventions) and the brain (e.g. emotional or excitability states). Critically, these gaps also extend to studies in disease, which currently limits our understanding of how embodied processing contributes to pathology. Generally, it is unclear how multimodal physiological rhythms interact not only with each other, but also with high-dimensional brain dynamics. I will address these challenges by combining state-of-the-art MEG neuroimaging, computational modelling, and comprehensive physiological recordings to develop a novel framework of body-brain dynamics in health and disease. I will probe body-brain coupling in consequence of short-term changes in body and brain states, i.e. induced by experimental manipulation (breathing interventions, cognitive-emotional tasks), longer-term changes like circadian rhythms, and pathological alterations of excitability states or respiratory mechanics. To widen the scope towards multimodal body-brain interactions, I will assess the link of respiratory and gastric rhythms with non-invasive olfactory bulb recordings during edible odour processing. This lays the groundwork for developing the first computational model describing whole-body-whole-brain interactions. Overall, this project will establish an explanatory model to describe function and dysfunction of multimodal body-brain coupling and redefine the way we conceptualise, investigate, and ultimately understand the interplay of body and brain.

Keywords: body brain interactions,embodied cognition,respiration brain coupling,respiration,physiology,computational modelling,brain body states
Nanoliter-Scale NMR of Biomolecule Solutions using Dynamic Nuclear Polarization (LiquidStateDNP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499950.0
EU funding (EUR): 1499950.0
Participants: 1
Project status: SIGNED

Dynamic nuclear polarization (DNP) is an exciting and rapidly developing field in magnetic resonance, with solid-state and dissolution DNP techniques emerging as powerful tools across various applications, ranging from materials science to medicine. However, direct DNP in solutions still suffers from a lack of general applicability to macromolecules. The LiquidStateDNP project aims to establish DNP spectroscopy in the liquid state as an innovative tool for chemistry and biology, enabling the analysis of biomacromolecules with small sample volumes as low as a few hundred nanoliters – an achievement beyond the capabilities of traditional NMR techniques. This research will focus on using the solid-effect mechanism at high magnetic fields and room temperature, which offers significant potential for investigating a wide range of molecules. Notably, the solid-effect mechanism exhibits a favorable dependence on the molecular weight of the analyte, becoming increasingly effective for larger macromolecules. To achieve the project’s goals, I will pursue the following objectives: (i) develop a DNP probehead with improved signal sensitivity and resolution; (ii) establish methodologies for various nuclei, including ¹H, ¹³C, ¹⁹F, and ³¹P; (iii) optimize the structure of polarizing agents to maximize their effectiveness in solid-effect DNP; and (iv) demonstrate the application of liquid-state DNP to biomolecules for the first time. This will involve monitoring ligand binding to nucleic acids or proteins, investigating the dynamics of native membranes, and conducting in-cell NMR studies on living cells to detect drug binding and penetration. The LiquidStateDNP project aims to develop an innovative tool for liquid-state NMR, unlocking fundamentally new opportunities for a variety of biological applications at the nanoliter scale under physiological conditions.

Keywords: nuclear magnetic resonance,dynamic nuclear polarization,electron paramagnetic resonance
OPEN AND PROGRAMMABLE ACCELERATORS FOR DATA-INTENSIVE APPLICATIONS IN THE CLOUD (CHORYS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Denmark,Germany,France,Italy,Switzerland,Netherlands
Call: Open Source for Cloud/Edge to support European Digital Autonomy (RIA) (HORIZON-CL4-2024-DIGITAL-EMERGING-01-CNECT, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4305637.5
EU funding (EUR): 4305637.5
Participants: 10
Project status: SIGNED

CHORYS directly prioritises support for data-intensive applications in the context of the European Open Computing Architecture by developing and demonstrating open and programmable accelerators. Through CHORYS, we will demonstrate that European cloud providers and their customers can leverage open accelerators for near-data processing and asynchronous data services to improve the performance, energy-efficiency, and cost of data-intensive applications. This overall goal is aligned with the expected impact of the topic destination as CHORYS will contribute to the next steps of development and adoption of Open technologies. More specifically, we expect that CHORYS will contribute to Europe taking a leadership position in RISC-V based accelerators, with a workforce highly skilled in hardware/software co-design. The consortium is uniquely positioned to take up this challenge. Codasip, Europe’s leading RISC-V company with billions of chips shipped, will commercialize RISC-V IP licenses and Electronic Design Automation (EDA) software subscriptions, demonstrated in the projects’ open accelerators. Menta, the pioneer embedded FPGA (eFPGA) company, which is part of the European Processor Initiative, will contribute to the development of a European programmable storage controller. Cyso will extend the CHORYS demonstrators to deploy open and programmable accelerators in their high-performance public cloud platform, resulting in orders of magnitude net cost savings. The universities partners have track records of successful collaborations with recently published breakthrough results on hardware-software co-design, near-data processing, and asynchronous data services.

Keywords: near data processing,accelerators,risc v isa extensions,data intensive applications
ARGOS (“Acoustic Reporter Gene Overhaul in Saccharomyces”) (ARGOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

As acoustic reporter genes (ARGs), gas vesicles (GVs) have recently seen a rapid rise in biomedical interest with applications including non-invasive diagnostics and treatment. Gas filled protein nanostructures, GVs are unique, genetically encodable microbubbles that provide a stable ultrasound contrast handle. Due to their complex assembly inside of cells, the use of GVs is currently constricted to a number of wild-type, minimally engineered gene clusters and the range of cells they can be deployed to is limited. By contrast, fluorescent proteins (FPs) as optical reporter genes can readily be deployed to any biological context and decades of protein engineering have imbued them with an expansive array of colors, improved brightness, and sophisticated applications. In this action, we aim to parallel the immense development achieved for FPs and overcome the limitations of re-engineering gas vesicles by linking their successful assembly in yeast cells to a clear optical readout, unlocking high throughput screening by FACS. Utilizing this platform, we will screen libraries of modularly assembled GV gene clusters for successful expression in S. cerevisiae. The Sc2.0 synthetic yeast genome platform will then enable the evolution of yeast genomes for superior GV assembly pathways using SCRaMbLE. Our novel GV gene clusters will be targeted for carefully guided directed (co-)evolution of one or multiple GV genes to develop synthetic GVs that provide improved contrast and phenotypes to expand their applications. To facilitate the swift engineering of ARGs for novel applications, we will obtain next-generation sequencing and single-cell RNA sequencing data of our GV genes and evolved yeast genomes to develop a deeper sequence to function understanding of GV expression in eukaryotes. This action, ARGOS, “Acoustic Reporter Gene Overhaul in Saccharomyces”, will prepare the next generation of GVs for researchers to peer beyond the limits of optical imaging.

Keywords: gas vesicles,directed evolution,scramble,acoustic reporter gene,protein nanostructures
Mechano-modulation of tumor microenvironment with mechanotherapeutics and sonopermeation to optimize nano-immunotherapy (MMSCancer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Cyprus
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Inefficient drug delivery to tumors can reduce dramatically treatment efficacy and thus, affect negatively the life of cancer patients. This is particularly evident in desmoplastic cancers where interactions among cancer cells, stromal cells and the fibrotic matrix cause tumor stiffening and accumulation of mechanical forces that compress tumor blood vessels. Indeed, in subsets of pancreatic cancers and sarcomas, 95% of intratumoral blood vessels may be compressed and up to 80% totally collapsed leading to reduced blood flow (hypo-perfusion) and drug delivery. Hypo-perfusion also leads to hypoxia that helps cancer cells evade the immune system and increase their invasive and metastatic potential. Use of mechanotherapeutics and ultrasound sonopermeation are two mechano-modulation strategies that separately have been employed to treat vascular abnormalities in tumors. Even though these strategies have reached the clinic, their promise has yet to be realized by cancer patients owning to limitations of the methods. My hypothesis is that these strategies can uniquely complement each other and have not only additive, but highly multiplicative synergistic effects on modulating the desmoplastic tumor microenvironment and improving the efficacy of the promising but still of limited use nano-immunotherapy. However, it is crucial that specific guidelines should be developed. To achieve this ground-breaking goal, I will employ a mixture of cutting-edge computational and experimental techniques. I will perform in vivo mice studies in pancreatic cancers and sarcomas to investigate under what conditions these mechano-modulation strategies can be optimally combined to improve treatment efficacy, prevent metastasis and increase survival. In parallel, I will develop new mathematical models to provide useful guidelines for optimizing the experimental protocol. MMSCancer will introduce novel therapeutic strategies for the treatment of drug resistant tumors leading to better therapies.

Keywords: bioengineering,biomechanics,computational models,mechanical properties,tumor pathophysiology,drug delivery,animal tumor models,ultrasound shear wave elastography
Finding the missing links in the bacterial cell cycle (MissingLinks)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Portugal
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 2999625.0
EU funding (EUR): 2999625.0
Participants: 1
Project status: SIGNED

The bacterial pathogen Staphylococcus aureus is currently the second most common cause of death associated with antibiotic resistant infections. The most useful antibiotics in clinical use have multiple targets, as compounds against single proteins rapidly succumb to the capacity of bacteria to develop resistance. To think innovatively about antibiotic discovery, we need to think not only about individual cellular processes, but also about how they are interconnected and coordinated, so that we can devise methods to strike bacterial cells, simultaneously, in multiple pathways. The bacterial cell cycle consists of a series of coordinated events required for bacterial growth, during which cells duplicate their mass and undergo chromosome replication and segregation, assembly of the division machinery, cytokinesis, and cell separation to generate two new daughter cells. Unregulated cell cycle progression may have lethal consequences for the cell and therefore bacteria have evolved various mechanisms for the precise spatiotemporal control of main cell cycle events. Some important checkpoints have been studied, particularly the link between chromosome replication/segregation and septum synthesis, to avoid DNA breaks. However, the mechanisms for coordination of other cell cycle events are still unknown. What triggers initiation of peptidoglycan synthesis, the target of beta-lactam antibiotics, after assembly of the division machinery? How does the cell coordinate synthesis of the membrane and peptidoglycan, the two major cell surface components, during cell division? What prevents premature septum splitting, which would expose an immature cell surface, devoid of virulence factors, leading to pathogen elimination by the innate immune system of an infected host? The aim of this project is to find the missing links between major cell cycle events, while also developing assays useful for antibiotic discovery.

Keywords: staphylococcus aureus,cell cycle,cell division,antibiotic resistance,flim fret,
Spreading Open and Inclusive Literacy and Soil Culture through Artistic Practices and Education (SOILSCAPE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Coordination and support actions
Countries involved: France,Greece,Germany,Poland,Bulgaria,Portugal,Italy,Finland,Belgium,Kenya,Switzerland
Call: Back to earth: bringing communities and citizens closer to soil (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 5997878.75
EU funding (EUR): 5997878.75
Participants: 19
Project status: SIGNED

SOILSCAPE harnesses the power of Cultural and Creative Industries (CCIs), artists, and civil society organisations (CSOs) to promote soil preservation across Europe and beyond. Working with experts from the worlds of soil sciences, arts, decision-making, and humanities, this project coordinated by AFES seeks to cultivate soil literacy and celebrate soils through creative approaches, engaging citizens & professionals on this journey. SOILSCAPE's objectives include understanding human-soil relations, building a network of more than 120 relevant actors in 8 countries, onboarding at least 320 individuals from the society, providing 1,850,000 € as financial and technical support to CSOs, CCIs, schools, artists, and institutions, distributing 375,000 € as awards and 80 soil literacy certifications to inspiring initiatives, and reaching international scales through UNESCO and Coalition of Action for 4 Soil Health. To achieve these objectives, SOILSCAPE uses a multilingual and multi-actor approach, focusing on cultivating artistic soil intelligence, promoting context-based soil literacy, enhancing awareness through innovative communication strategies and a soil literacy portal, organising 2 editions of national soil festivals across Europe, and extending its actions to 30 regions by 2028. The project unfolds through 4 key stages: (1) Contemplation: Consulting stakeholders to understand individual perception on soils, arts, and links with societal values; Investigating soil narratives and the potential of arts and arts-based methodologies to engage in soils; (2) Preparation: Developing people-centric transformative strategies, including an artistic and creative international soil network; (3) Action: Conducting and monitoring the SOILSCAPE creative activities, including the support to 28 arts-soils initiatives led by third parties; (4) Sustainability: Validating and replicating the SOILSCAPE initiatives at large scale.

Keywords: arts based,soil heroes,human soil relations,soil health,soil experts,soils