Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Multi-Variate Analysis for New Physics Searches at the LHC (AMVA4NewPhysics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy,Italy,Italy,Switzerland,Belgium,Greece,Belgium,Russian Federation,Switzerland,France,United States,United Kingdom,Portugal
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 2393361.31
EU funding (EUR): 2393361.31
Participants: 16
Project status: CLOSED

With the 2012 discovery of the Higgs boson at the Large Hadron Collider, LHC, the Standard Model of particle physics has been completed, emerging as a most successful description of matter at the smallest distance scales. But as is always the case, the observation of this particle has also heralded the dawn of a new era in the field: particle physics is now turning to the mysteries posed by the presence of dark matter in the universe, as well as the very existence of the Higgs. The upcoming run of the LHC at 13 TeV will probe possible answers to both issues, providing detailed measurements of the properties of the Higgs and extending significantly the sensitivity to new phenomena. Since the LHC is the only accelerator currently exploring the energy frontier, it is imperative that the analyses of the collected data use the most powerful possible techniques. In recent years several analyses have utilized multi-variate analysis techniques, obtaining higher sensitivity; yet there is ample room for further improvement. With our programme we will import and specialize the most powerful advanced statistical learning techniques to data analyses at the LHC, with the objective of maximizing the chance of new physics discoveries. We aim at creating a network of European institutions to foster the development and exploitation of Advanced Multi-Variate Analysis (AMVA) for New Physics searches. The network will offer extensive training in both physics and advanced analysis techniques to graduate students, focusing on providing them with the know-how and the experience to boost their career prospects in and outside academia. The network will develop ties with non-academic partners for the creation of interdisciplinary software tools, allowing a successful knowledge transfer in both directions. The network will study innovative techniques and identify their suitability to problems encountered in searches for new physics at the LHC and detailed studies of the Higgs boson sector.

Keywords: large hadron collider,physics beyond the standard model,searches for new phenomena,higgs boson physics,multi variate analysis,data analysis,statistical learning,data science
Multi-particle scattering amplitudes for precision collider physics (MPAmplitudes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Scattering amplitudes determine the probability of interactions between fundamental particles. They are essential ingredients for phenomenological predictions in high-energy physics. Experiments at modern colliders, such as the Large Hadron Collider (LHC) at CERN, are probing fundamental interactions at previously unexplored scales of energy. The high energy involved in these interactions is responsible for the production of many particles in the final state, which needs to be theoretically understood with high accuracy in order to make the most out of experimental data. The goal of this research project is the analytic calculation of multi-particle scattering amplitudes at higher orders in perturbation theory, and in particular the two-loop five-point amplitudes in quantum chromodynamics, needed for theoretical predictions at next-to-next-to-leading order in perturbation theory. These are of great relevance for LHC phenomenology, since our success in finding new physics can depend on our capability of distinguishing its effects from the large QCD background of multi-particle processes, which needs to be known with high precision. The method used for the calculation builds upon state-of-the-art techniques, such as multi-loop integrand reduction and generalized unitarity. These techniques exploit the knowledge of the universal analytic and algebraic structure of amplitudes, and are suited for handling the complexity of multi-particle calculations. The technologies and tools which will be developed for this project are very general and will thus provide a framework useful for future precision calculations, opening up a new frontier for high-precision multi-particle theoretical predictions for collider experiments.
Evaluation of Dyadic Psychoeducational Interventions for People with Advanced Cancer and their Informal Caregivers (DIAdIC): An international randomized controlled trial (DIAdIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Belgium,Belgium,Belgium,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Novel patient-centred approaches for survivorship, palliation and/or end-of-life care (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 4277875.0
EU funding (EUR): 4277875.0
Participants: 11
Project status: SIGNED

Background: Advanced cancer affects millions of Europeans each year. The provision of adequate and cost-effective psychosocial and educational support for both patients and their frequently overburdened family caregivers is highly relevant from an economic, a healthcare and a prevention perspective. Aims: The DIAdIC project is an interdisciplinary, cross-national project to evaluate the effectiveness and cost-effectiveness of two psycho-educational dyadic interventions, i.e. interventions that target the patient and family caregiver together. One intervention is a web-based e-health intervention, one is nurse-led face-to-face intervention. Secondary aims are to assess the interventions' effects on vulnerable subgroups (e.g. people with a lower socioeconomic position), their effectiveness in different healthcare systems, and their suitability as perceived by end-users. Concept and methods: The two interventions are tailored to dyads' needs and have 5 core components: (1) supporting family involvement, (2) reducing hopelessness, (3) increasing coping effectiveness, (4) reducing uncertainty and (5) teaching symptom management. They are based on existing interventions, developed in the USA, that have been shown to improve quality of life of both patient and family caregiver. The effectiveness of each of the interventions (compared to care as usual) will be assessed by way of an international randomized controlled trial in people with advanced cancer and their primary informal carers. The project includes a full health-economic evaluation and a thorough process evaluation. Impact: The project advances the state of the art in several ways, e.g. by providing innovative healthcare interventions (including a eHealth solution) that embrace the philosophy and principles of early palliative care. The interventions will be suitable for implementation across diverse healthcare systems. Public involvement methods ensure the input of stakeholders throughout the project.

Keywords: palliative care,supportive care,advanced cancer,informal caregivers,family carers,psycho social,support,self management,ehealth
Comprehensive Investigations of Aerosol Droplet Surfaces and Their Climate Impacts (AeroSurf)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 2315245.0
EU funding (EUR): 2315245.0
Participants: 1
Project status: SIGNED

By serving as cloud droplet seeds, aerosols represent the largest negative (cooling) and most uncertain climate forcing. Particulate matter is also a major contributor to air pollution, attributed to ~7 million annual deaths. Aerosol surfaces hold the greatest source of uncertainty for atmospheric chemistry and climate impacts. Surfactants are now routinely identified within atmospheric aerosol samples, and surface tension governs the fraction of particles that activate into cloud droplets, significantly impacting aerosol-cloud climate effects. Sunlight-driven interfacial reactions have recently emerged as important modifiers of atmospheric composition and proceed via unique pathways relative to bulk solutions. A complete understanding of aerosol climate and health impacts requires detailed knowledge of aerosol surface composition and reactivity. However, few approaches directly interrogate droplet surfaces, hindering incorporation of surface-mediated processes into climate and air quality models. This project will study directly the droplet-air interface of picolitre droplets in size ranges relevant to growing cloud droplets to develop a comprehensive, molecular level understanding of interfacial composition, reactivity, and climate and health impacts. Aerosol droplet surfaces will be studied with novel, sensitive approaches. The dynamic and equilibrium partitioning of surfactants to aerosol droplet surfaces will be investigated directly for the first time, providing information required for accurate cloud droplet activation predictions. Entirely new approaches to selectively analyse the surface and bulk molecular composition of a levitated micron-sized droplet by mass spectrometry will allow direct investigation of chemistry on aerosol surfaces. Together, these approaches will address outstanding questions in interfacial photochemistry, link directly droplet surface tension to climate impacts, and resolve a poorly understood aspect of aerosol chemistry.

Keywords: aerosols,cloud droplet activation,interfacial photochemistry,mass spectrometry,optical tweezers,single particle analysis,surface composition
The CD44-RANK-AKT Crosstalk in Breast Cancer and Stemness (BREASTCANCERSTEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Relapse and metastasis in cancer are driven by cancer stem cells (CSC) which self-renew, give rise to tumor cell heterogeneity and are more resistant to chemotherapy. The RANK signalling pathway is implicated in a number of cancers and notably in breast carcinogenesis and metastasis. Inhibition of this pathway reduces CSCs decreasing both recurrenceRelapse and metastasis in cancer are driven by cancer stem cells (CSC) which self-renew, give rise to tumor cell heterogeneity and are more resistant to chemotherapy. The RANK signalling pathway is implicated in a number of cancers and notably in breast carcinogenesis and metastasis. Inhibition of this pathway reduces CSCs decreasing both recurrence and metastasis. RANKL inhibitors are used in breast cancer clinical trials and studies focused on RANK signalling in carcinogenesis are needed to identify patients who would benefit from treatment. RANK mediates many of its effects on cell survival, migration and chemoresistance via the PI3K/AKT pathway, activation of which confers enhanced proliferation, survival, metastatic potential and resistance to therapy in cancer. AKT is a central node in PI3K signalling and AKT isoforms play important and differential roles in carcinogenesis. RANK is also regulated by CD44, a marker of stemness and a key player in cell migration, proliferation, differentiation, survival, stem cell maintenance and chemoresistance. CD44 alternative splicing plays a pivotal role in cancer development in breast and other tissues. However, the role of CD44 and AKT isoforms in cancer is not clearly defined. In this MSCA project, I will investigate the role of the CD44-RANK-AKT crosstalk in tumorigenesis and identify CD44 and AKT isoforms regulating cancer stemness, metastasis and resistance to therapy. I hypothesize that the interplay between CD44, RANK and AKT regulates cancer stemness and the metastatic potential of breast tumor cells, and specific CD44 and AKT isoforms have vital roles in this process.

Keywords: breast cancer,cancer stem cells,metastasis,stemness,cscs,rank,cd44
Breakthrough Solutions for the Sustainable Harvesting and Processing of Deep Sea Polymetallic Nodules (Blue Nodules)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Norway,Belgium,Belgium,Hungary,France,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Deep mining on continent and/or in sea-bed (H2020-SC5-2015-one-stage, 2015)
Start date: 2016-02-01
End date: 2020-07-31
Duration (months): 54.0
Total project cost (EUR): 7991137.5
EU funding (EUR): 7991137.5
Participants: 20
Project status: CLOSED

A key EU policy aims to reduce the Union dependency on raw materials imports, in particular (candidate) Critical Raw Materials that are vital for the EU innovative technologies. Topic SC5-11c-2015 scope focuses on “developing new highly-automated technological sustainable solutions for deep mining … in the sea bed combined with in-situ processing of minerals”. An existing but challenging raw material resource concerns polymetallic nodules. These round to elongated concretions of 1–15 cm diameter form on sediment-covered deep-sea plains in all oceans between 4-6000m water depth. The challenge to harvest and transport the nodules to the EU shore is taken on by Blue Nodules. The governing project principle is: industrial viability within the context of a realistic and technical, economic and environmentally balanced business case for the complete Polymetallic Nodules value chain of mining, processing and valorisation. Blue Nodules will develop and test to TRL6 maturity a new highly-automated and technologically sustainable deep sea mining system. Key features are: an annual production capability of 2 Million Tons nodules in water depths up to 6000m, in-situ processing of the nodules and intrinsic safe working conditions. Technical WPs are dedicated to subsea harvesting equipment & control technology, in-situ seafloor processing of polymetallic nodules and sea surface, land operations & processes. A dedicated WP focuses on environmental issues and on an Environmental Impact Assessment (EIA). A WP setting requirements and assessing the developed technology controls the entire work plan structure. High credibility is obtained by linking the project work to a nodule field licence owned by a project partner and located in the most promising known nodule deposit: the Clarion Clipperton Zone. The project consortium contains 14 leading industry and research partners from 9 EU member states. The project duration is 48 months, the required funding amounts to 8 Million.

Keywords: polymetallic nodules,manganese,nickel,coper,cobalt,sustainable harvesting,economic value chain
Discriminatory and Nondiscriminatory Trade Costs (COST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-15
End date: 2018-08-14
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

In recent decades, Regional Trade Agreements (RTA) have become increasingly prevalent. A common way of assessing costs and benefits of RTAs is by using Computable General Equilibrium (CGE) approach. CGE based studies then use this framework to forecast for example, the trade growth, job creation, and welfare gains from forming RTAs. Unfortunately, their predictions poorly match the actual medium to long run outcomes of existing RTAs. With RTAs such as the Trans-Pacific Partnership (TPP) and the Transatlantic Trade and Investment Partnerships (TTIP) currently under negotiation, CGE analysis plays a central role in the negotiation process. Therefore the accuracy of CGE models is of paramount importance. One way in which modern CGE models fall short is in their overly simplistic approach to trade costs. This includes both their measurement and their place in the underlying model. In particular, CGE studies to date fail to account for within-country trade costs, i.e. trade costs which are non-discriminatory as they apply to both domestic and foreign firms. Instead, they focus solely on discriminatory trade costs which apply only to foreigners. This has critical implications both in how to measure trade costs (as many compare within-country to cross-border trade and therefore combine discriminatory and non-discriminatory trade costs) and in how to include them in the analysis. As the goal of RTAs is to reduce trade barriers, this oversight can result in incorrect expectations on an RTA's impact and therefore wrong policy recommendations. The aim of COST project is to develop trade cost measures and specifications for modelling impacts of trade costs for CGE models that overcome these methodological and modelling limitations and consequently improve accuracy of future CGE studies in predicting the costs and benefits of RTAs.

Keywords: trade costs,gravity
Industrial Structure and the European Productivity Growth Divergence (ISEProD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1944581.0
EU funding (EUR): 1944581.0
Participants: 1
Project status: SIGNED

The last two decades have witnessed substantial progress in the measurement of productivity. However, our understanding of the deep determinants of productivity growth is still limited. This is important in the face of both the global productivity slowdown emerged since mid 2000s and the large productivity growth divide in Continental Europe between the North and the South. I hypothesize that ownership, control and finance (in short "industrial structure'', IS) play a key role and that their importance, due to technological change, has grown over time. I plan to merge insights and state-of-the-art techniques from industrial organization and corporate finance to assess the causes and consequences of different ISs. Methodologically, I will use a combination of unique data sources (credit register, matched employer-employee data, firm input-output relationships), quasi-experimental design (changes in the banking regulation, executives mortality shocks in local labor markets) as well as structural techniques (selection models and Bayesian learning models) to address the fundamental identification issues that plague the literature. I also plan a major data collection effort in four European countries to study succession in family firms. The project will pursue four specific objectives in four deeply integrated work packages: a) The role of firm ownership and control on skill acquisition and risk taking; b) Skills supply: the effects of the education of entrepreneurs and managers; c) Industrial structure, input/outut relationships and IT adoption; d) Access to finance with asymmetric information and imperfectly competitive financial markets. The ambition is to generate a discontinuous change in our understanding of the relationship between corporate governance/finance and productivity growth. On the way, I expect to contribute to the key debate for the future of the European Union on the diverging productivity performance of European economies.

Keywords: productivity growth,corporate governance,european divergence
Origin and Composition of Exocomets Around Nearby Stars (OCEANS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: CLOSED

The presence of exocometary gas in young (10-100 Myr) debris disks presents a unique opportunity to probe the composition of exocomets during the late stages of terrestrial planet formation. This is the evolutionary stage when ice-rich impacts are proposed to change the volatile environment of terrestrial planets, setting the stage for prebiotic chemistry. This action will establish a new paradigm of Exocometary Science as a unique tool for probing the composition of planetary systems in the crucial, last period of terrestrial planet formation. I will expand current observational approaches, focused on observations of CO gas at millimetre wavelengths, to UV and IR wavelengths, in order to access atomic and yet unseen molecular species, including water, to probe the entire chemical variety of exocomets. In doing so, I will exploit existing observational facilities and prepare for upcoming sensitive observatories such as JWST. Additionally, I will study the origin of exocomet compositions - so far consistent with Solar System comets - and their link to a potentially common belt formation location in young protoplanetary disks. This action will set the stage for compositional inventories of exocomets, allowing us to put our Solar System comets into the broader context of extrasolar planetary systems, exoplanets and young disks, and providing a missing link in the study of planet formation and physical-chemical evolution.

Keywords: exocomets,small bodies in extrasolar planetary systems,debris disks