Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable Marine Energy and Ecosystem Resilience Advancement through Digital Technologies and Real-Time Crisis Management (SeaDream)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark,United Kingdom,Luxembourg,Canada,United States,Serbia,Spain,Ireland,Germany,China,India
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 534914.29
EU funding (EUR): 515200.0
Participants: 15
Project status: SIGNED

The project aims to strengthen EU efforts towards achieving climate neutrality and achieving green energy and environmental targets. SeaDream plays a crucial role in making sure marine energy is utilized sustainably and coastal environments are preserved in line with EU policies. The development of a high-resolution water quality data service at sea is at the core of SeaDream's mission. Data such as these are crucial to addressing specific questions regarding maritime renewable energy generation and storage. The project integrates local monitoring data and advanced modeling through the development, testing, and demonstration of novel downstream information services in an operational mode. As a result of this integration, marine activities related to the generation and storage of energy are improved, and environmental objectives are not compromised. By harnessing advanced data and fostering collaboration across sectors, the project aims to contribute significantly to the EU's environmental and energy targets, promoting a path towards climate neutrality. In order to achieve SeaDream's vision, a coordinated research program that thrives on collaboration is implemented. In this program, leading teams from academic and private sectors are seconded within and outside the EU. Collaborations are enhanced by periodic workshops and summer schools that disseminate the latest findings and promote market-relevant knowledge application. It is designed to foster the advancement of knowledge and career development for both experienced and early career researchers and professionals. To ensure this, secondments and training activities are structured to ensure a comprehensive approach to learning and development. Additionally, the SeaDream consortium includes nonacademic partners from various stakeholder groups, which facilitates direct application of project results.

Keywords: offshore energy
PathsToDormancy: Identifying dormancy pathways for selective targeting (PathsToDormancy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The survival and propagation of species fundamentally depend on the precise regulation of cellular growth and dormancy. This balance is crucial across various biological processes including reproduction, regeneration, and repair, where mechanisms such as embryonic diapause allow organisms to endure adverse conditions by temporarily halting development. During this dormant state, embryonic cells undergo significant rewiring of their transcriptional, epigenetic, and metabolic pathways, preserving their stem cell characteristics and enabling reactivation under more favorable conditions. Despite its essential role, dormancy presents challenges in cancer treatment. Cancer cells exploit conserved dormancy pathways to evade therapies, resulting in drug-tolerant persister (DTP) cells that can survive treatment, potentially leading to relapse with more aggressive and metastatic tumors. This phenomenon undermines efforts to combat cancer, as detecting and targeting dormant cancer cells remains a significant obstacle. Here we will leverage our in vitro dormancy culture systems identify regulators of cancer dormancy with embryonic origin.
Galaxy mergers in the era of large surveys (GalaxyMergers)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-03
End date: 2025-11-02
Duration (months): 28.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

As galaxies are formed, to a large extent, by merging of smaller galaxies, knowing the merger history of the observed galaxies is crucial to understand their evolution as well as the evolution of the whole Universe. Galaxy mergers are slow processes, happening over millions of years and so the information about the merger history of any individual galaxy must be indirectly derived from its present-day state. Luckily, a significant portion of elliptical and lenticular galaxies show a unique type of fine structure known as stellar shells, which are created in mergers and can be used to date the last significant merger that the galaxy has undergone. We have already developed methods to extract such information from individual galaxies. Now we will expand the applicability of such methods to vastly larger samples. To this end, we will develop a set of self-contained tools to identify and analyze shell galaxies in images of large sky surveys, so that the estimates of merger times can be automatically obtained. We will apply those tools on existing data from current surveys and prepare for their application to the unprecedentedly large data set that will be produced by the Large Survey of Space and Time (LSST) at the Vera C. Rubin Observatory, which will become operational around the time when the project concludes. This will transform shell galaxies from a position of curiosity to that of utility, allowing statistical applications using the merger data on the hundreds of shell galaxies that will be identified in the existing data and later on the thousands of galaxies eventually observed by the LSST project – a huge qualitative leap from the handful of galaxies with known merger histories available today. We will pioneer the use of this data by applying it for the benefit of LSST itself, where it will help optimize the observation time in search of transients by exploring the correlation of their occurrence with the merger histories of the host galaxies.

Keywords: galactic evolution galactic interactions elliptical and lenticular galaxies peculiar galaxies numerical simulations tidal features deep imaging
LIBERATION ANALYSIS FOR OPTIMIZING EXTRACTION AND PROCESSING OF CRMS (BLOOM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Spain,Portugal,Canada,Ukraine,Belgium,Brazil
Call: Technologies for extraction and processing of critical raw materials (IA) (HORIZON-CL4-2024-RESILIENCE-01, 2024)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 8810532.41
EU funding (EUR): 7488018.02
Participants: 16
Project status: SIGNED

The CRM Act, together with other EU policies towards the green and digital objetives of the CE, and the EU current context pose some challenges and needs to the extractive and processing industries: improve and facilitate access to raw materials and reduce EU dependency; increase circularity, ensure recycling into secondary raw materials and recovery from extractive waste; ann also, the mining and processing industry must be sustainable, thus competitive, socially responsible and efficient in terms of cost, reducing energy consumption and gas emissions. BLOOM aims to develop and demonstrate extraction and processing technologies to facilitate exploitation of the primary raw critical raw materials. For this, th ecollaboration with both Ukraine and Canada is envisioned 2 and 3 partners from these countries respectively); clustering activities are envisioned through key partners and a a business case and exploitation strategy. BLOOM will tackle the challenges through its Strategic Objective which is to facilitate exploitation of the primary CRM (minerals and metals only) for the EU to strengthen the EU supply chains, by increasing the efficiency on extraction and processing with a smart and modular solids analysis system consisting on an online mineral liberation analysis, which enables the integration on mining sites of advanced control loops in different stages of the processing, based on ML and AI techniques, or data-driven extraction operations based on accurate mineralogy information from the site. These actions are oriented to lowering the costs of extraction and processing, increasing the financial viability, thus also contributing to making profitable low-grade deposits, giving access to new supplies. BLOOM consortium is composed of a multidisciplinary group of 15 partners, from 4 European countries, 2 from Ukraine, 3 from Canada and 1 from Brazil, one of the resource-richer countries in the world and lead by UPC.

Keywords: crm,sustainability,optimization,analysis,critical,raw,material
Taking blood apart by sound (TAPAS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-05-01
End date: 2024-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Separation of blood components is of high importance in healthcare and often require fractionation of blood in its subcomponents by centrifugation. There are several scenarios that calls for improved resolution: 1. When blood is drawn from a donor and a specific cell type is extracted while returning remaining blood components. 2. In cancer immunotherapy where T-cells are isolated from the blood and then genetically reprogrammed to be re-infused in the patient where they seek up and destroy cancer cells. 3. Circulating tumor cells, which are involved in the process of formation of metastases in cancer patients, can be detected and monitored by extracting cancer cells in large volumes of blood. 4. Improving the quality and reducing the number of manual procedures in diagnostic instrumentation that analyzes blood. Centrifugation has the fundamental drawback of having rotating parts, and thereby taking up space and being difficult to implement for flow-through processing which is desirable both for integration in analytical equipment and for processing blood for continuous re-infusion into a person. We will investigate an alternative to centrifugation wherein blood components are separated by a sound field. Cells will be separated based on differences in density and size while flowing through an acoustic separator module. Recent ERC-funded research indicates that this approach is feasible, but three scientific questions has been identified with fundamental impact on the commercial potential of this technology: 1. How selectively can sub-groups of blood cells be separated by acoustic separation? 2. Can acoustic separation be scaled for high throughput applications? 3. Can acoustic separation affect blood cells? To address this, my team will design and build two prototype systems for whole blood processing and evaluate the quality and throughput of the separation with the ultimate goal of bringing this technology to the market for the benefit of society.
Beyond COVID (BY-COVID)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Other destinations
Action type: Research and Innovation actions
Countries involved: Germany,Netherlands,Luxembourg,Estonia,Hungary,Italy,Sweden,Belgium,United Kingdom,Czechia,Spain,Denmark,Switzerland,Austria,Norway,Finland,Greece,Slovenia,France,Korea, Republic of
Call: FAIR and open data sharing in support to European preparedness for COVID-19 and other infectious diseases (HORIZON-INFRA-2021-EMERGENCY-01, 2021)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 12007500.0
EU funding (EUR): 12000000.0
Participants: 56
Project status: CLOSED

Beyond-COVID (BY-COVID) aims to provide comprehensive open data on SARS-CoV-2, and other infectious diseases across scientific, medical, public health and policy domains. The project will have a strong emphasis on mobilising raw viral sequences, helping to identify and monitor the spread of SARS-CoV-2 variants. It will further accelerate access to and linking of data and metadata on SARS-CoV-2 and COVID-19, enable federated data analysis conform with data protection regulations, and harmonisation and management of meta-data and sample- identifiers, as well as long-term cataloguing to ensure interoperability of national and global efforts. BY-COVID will align with the One-Health approach building on the latest technological advances, exploiting and contributing to the European Open Science Cloud capabilities for data access and federation as well as relevant standards and policies for managing, sharing and reusing research data, and work closely with the proposal funded through the sibling-topic from the emergency call (HORIZON-INFRA-2021-EMERGENCY-02). BY-COVID will integrate established national and European infrastructures including ELIXIR, BBMRI, ECRIN, PHIRI and CESSDA. It will build on existing efforts, such as the COVID-19 Data Platform and the Versatile emerging infectious disease observatory project (VEO), thereby maximising efficiency. Synergies with the European Health Data Space will be developed. BY-COVID is a truly interdisciplinary (55 partners from 19 countries) project bringing together stakeholders from the biomedical field, hospitals, public health, social sciences and humanities in an unprecedented and unique effort and will increase European readiness for future pandemics enhance genomic surveillance and rapid-response capabilities. The outputs of the project will allow scientists across multiple domains, including SMEs and industry, to access a range of data that will generate new knowledge on infectious disease.

Keywords: covid,sars cov 2,open data,infectious diseases,research infrastructures
Soils for Europe (SOLO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Coordination and support actions
Countries involved: Spain,Netherlands,Germany,Bulgaria,Sweden,Portugal,Finland,Hungary,Greece,Norway,Belgium,Italy
Call: From knowledge gaps to roadmaps on soil mission objectives (HORIZON-MISS-2021-SOIL-02, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 5000013.75
EU funding (EUR): 5000013.5
Participants: 19
Project status: SIGNED

Soils are under multiple pressures, including climate change, urbanization, pollution, overexploitation, and biodiversity loss. The specific objectives of the EU Mission ‘A Soil Deal for Europe’ address all these pressures, needing now: i) actionable research and innovation roadmaps for its concretization; and, ii) an overarching transdisciplinary agenda to identify the thematic and regional trade-offs and synergies that allow the sustainable use, management, and protection of European soils. Defining such an agenda requires the direct involvement of a wide range of stakeholders, bringing together multiple perspectives and ecological, environmental, economic and social contexts. To do that, at the core of SOLO will be the implementation of Think Tanks, one for each Soil Mission objective, with the aim of co-creating knowledge and identifying the knowledge gaps, drivers, bottlenecks, and novel approaches, as well as suggesting KPIs to monitor the progress of the Mission R&I related activities. Together with an open digital platform, the Think Tanks will function as an operational tool for implementing a participatory process that will last beyond SOLO's lifespan. SOLO will also address the potential differences in the regional implementation of the Soil Mission by testing its approach in four co-creation Regional Nodes, generating their own regional roadmaps that will be matched with the European ones. These explicit linkages between the co-creation mechanisms and the different project components aim to produce a shared understanding of needs and comprehensive identification of research and innovation priorities and other critical activities for the success of the Soil Mission.

Keywords: transdisciplinary research,policy support,soil research and innovation,soil mission,soil drivers and sustainable use,climate land use change,roadmaps,stakeholder engagement,capacity building
Artificial intelligence enabled by automatic dynamic exploration of integrated photonic spiking neural networks (ARIADNE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: CLOSED

In this project (ARIADNE) I will address several key challenges of today’s hardware-based neuromorphic computing by developing a novel AI system based on a highly complex, dynamical and nonlinear integrated photonic neural network that is easy to fabricate and consumes low power. The proposed implementation is enabled by an original machine learning approach which allows to considerably relax the requirements on fabrication reproducibility and on observability and tunability of the network parameters. The AI system is expected to learn to perform multiple complex and time-dependent computational tasks at high speed within a compact device, finding application in real-time control with enhanced cybersecurity (robotics, autonomous vehicles, internet of things, …) and physiological signals analysis (e.g. prediction of epileptic seizures). ARIADNE will be hosted by the NanoLab research group at the University of Trento (UNITN). The project acronym is inspired by the ancient Greek myth of Theseus and the Minotaur, where princess Ariadne comes up with an ingenious way to help Theseus escape the labyrinth. In ARIADNE I aim to let a reinforcement learning algorithm learn to solve, loosely speaking, the spatio-temporal maze represented by the complicated dynamics in the considered networks of integrated optical resonators. In particular, the reinforcement learning algorithm will learn to control a complex feedback loop in order to set favorable dynamical network properties that allow to carry out target computational tasks. The AI system is expected to learn to perform multiple complex and time-dependent computational tasks at high speed within a compact device, finding application in real-time control with enhanced cybersecurity (robotics, autonomous vehicles, internet of things, …) and physiological signals analysis (e.g. prediction of epileptic seizures).

Keywords: neuromorphic photonics,spiking neural networks,integrated silicon photonics,machine learning,ring resonators,reservoir computing,reinforcement learning,on chip learning,edge computing
Chemogenetics Application and PhotoActivated ChemoTherapy to study Multidrug Resistance in Glioblastoma (target4ROS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 2
Project status: SIGNED

Cancer therapy faces significant challenges due to multidrug resistance (MDR), which reduces the effectiveness of chemotherapeutic agents. A key factor influencing MDR is the altered redox state within cancer cells, characterized by varying levels of reactive oxygen species (ROS). Understanding the dynamics of ROS is crucial, as they can both promote and inhibit tumor progression. Glioblastoma, a highly aggressive and treatment-resistant brain cancer, exemplifies the challenges associated with MDR, often exacerbated by a hypoxic tumor microenvironment and elevated ROS production. This project aims to investigate the role of ROS in MDR by integrating PhotoActivated ChemoTherapy (PACT) and recombinant D-amino acid oxidase (DAAO), a chemogenetic tool that is able to generate hydrogen peroxide (H2O2), the most stable ROS, within specific cellular compartments. PACT is an innovative anticancer treatment utilizing ruthenium-based (Ru) compounds that are selectively activated by red light in an O2-independent manner, minimizing damage to healthy tissues. In this project, I will implement DAAO to introduce controlled levels of H2O2 into glioblastoma cells, and then treat the cells with PACT, targeting NAMPT, a protein involved in the recycling of NAD+. I will correlate cancer cell resistance to PACT treatment with ROS levels, which will be monitored via Genetically Encoded Fluorescent Indicators (GEFIs). The project includes i) developing targeted ROS generation systems during a secondment at the nearby hospital, ii) exploring cellular adaptive responses, and iii) conducting in vivo mouse studies to validate the results from in vitro experiments. This project aims to combine chemogenetic applications and PACT for the first time. This innovative research has the potential to provide significant insights into the role of ROS in cancer therapy resistance, and to propose effective strategies to overcome MDR, thereby advancing glioblastoma treatment.

Keywords: photoactivated chemotherapy,ros,multidrug resistance,cancer,glioblastoma,ruthenium,chemogenetics,genetically encoded fluorescent indicators,proteomics,real time imaging,cytotoxicity