Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SHADOW: An exploration of the nature of informal economies and shadow practices in the former USSR region (SHADOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Estonia,Italy,Uzbekistan,Ukraine,Ireland,Romania,Sweden,Russian Federation,Georgia,Latvia,Kazakhstan,Kyrgyzstan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-03-01
End date: 2023-02-28
Duration (months): 60.0
Total project cost (EUR): 900000.0
EU funding (EUR): 810000.0
Participants: 12
Project status: SIGNED

Extending from Eastern Europe to Eastern Asia, from the Caucasus to Central Asia, the post-USSR region, occupying almost one sixth of the world’s territory, has an immense potential for the EU as source of natural resources and potential market for EU companies. In spite of this, the region is often seen as a highly hazardous one to deal with, given its “uncertain business and investment climate with widespread opportunism and corruption, misuse and misappropriation of state assets and conflicting information flow” SHADOW is a research and training programme with the goal of producing strategic intelligence on the region and train a generation of specialists on informality in post-Soviet spaces. Our goals are two-fold: 1) we intend to construct an index to provide an accurate measurement of the level of shadow activities in our target countries; 2) we aim to conceptualise a taxonomy of shadow practices in the post-USSR region in a cross-country and cross-regional perspective. Both goals are intended to contribute to a much better understanding of the threats and opportunities that the former USSR region, of fundamental importance for the EU, offers.

Keywords: informality,post soviet,central asia,caucasus,russia,business
The Beta Testing Campaign Platform for Research Projects (ReachOut)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Germany,France,France
Call: Software Technologies (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 499830.0
EU funding (EUR): 499830.0
Participants: 3
Project status: CLOSED

European research projects are expected to deliver results for reuse by other research projects and integration by business users. In both cases, to increase the chance of a tangible impact, research projects must deliver results that are well packaged, easy to understand and easy to use. ReachOut addresses this need with a two-prong solution. First, by educating research projects on the methodology and benefits of beta testing and, second, by providing a platform with tools and functional resources to launch beta testing campaigns, recruit beta testers and collect feedback. The ReachOut concept is summarized as follows: If a project is able to launch a beta-testing campaign of its results, it has what it takes to bring value to the market, engage with other research projects, users, partners and contributors and develop its own ecosystem. By encouraging partners to work together to enhance the market maturity of the product of their research, a beta testing campaign is a best practice to deliver valuable and exploitable results. A beta testing campaign is a technico-marketing initiative in which, on one hand, provisional software is combined with product attributes such as proper packaging, user interface and documentation so as to make it understandable and easy to use and, on the other, beta testers are recruited and incentivised to provide feedback with the possibility of winning a prize. Unlike conventional, usually project-centric support actions, ReachOut is market-oriented. Its aim is to generate actual connections between research projects, third-party research projects and real-life market users. ReachOut project partners demonstrate solid expertise stemming from their day-to-day business activities and dissemination and support experience gained from a dozen EU-funded projects, including successfully delivering the Ocean Directory of cloud projects, the AppHub marketplace for open source projects and the CHOReVOLUTION beta testing campaign.

Keywords: software beta testing campaigns,market oriented support action
Rethinking Employment Law for a world of Algorithmic Management (iManage)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1496131.0
EU funding (EUR): 1496131.0
Participants: 1
Project status: SIGNED

Amidst important debates about the gig economy and the automation of jobs, employment law has paid scant attention to the rise of algorithmic management: the increasingly pervasive reliance on monitoring technology and sophisticated algorithms to measure, control, and sanction workers. This poses a fundamental threat to the legal regulation of our labour markets. Automated management allows the exercise of hitherto impossibly granular employer control. At the same time, however, the absence of clear decisions and traditional management structures appears to disperse responsibility ‘into the cloud’. How can employment law respond to a world in which automation has not replaced workers—but their bosses? This pioneering project will develop the first systematic account of the challenges and potential of algorithmic management, examine its implications for legal regulation, and develop concrete solutions to avoid harmful path-dependencies. It tackles a risky challenge that goes right to the core of employment law’s existing structures, with technology developing at unprecedented and unpredictable scale. Looking at a range of jurisdictions across the European Union and beyond, iMANAGE requires the development of novel, interdisciplinary methodology at the intersection of data science and employment law. In articulating the underlying structures of automated management control, it develops a new and positive role for employment law in ensuring algorithmic accountability, and shaping the responsible use of technology in the workplace. This is a challenge we cannot shy away from: both the theoretical foundations of employment law, and its practical operation across different jurisdictions, depend on understanding and regulating the radically different organisation of the workplace of tomorrow.

Keywords: algorithmic accountability,control,job automation,gig economy,future of work,discrimination,privacy,gdpr,non standard work,labour market regulation,social partners,comparative labour law
Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Disease (INVADERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 1850000.0
EU funding (EUR): 1850000.0
Participants: 1
Project status: SIGNED

Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Disease Humanity is facing an epidemic of inter-related metabolic disorders, including obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hepatic steatosis, that altogether have major impact on the promotion of cardiovascular diseases. The increasing incidence of these complex metabolic disorders and their highly morbid, chronic and costly downstream diseases threatens to overwhelm the world’s health care systems and economies, making it a top public health priority in dire need of investigation. The intestinal tract is inhabited by a large and diverse community of bacteria, collectively referred to as the intestinal microbiota. When stably maintained at an appropriately safe distance from the epithelial cell monolayer, the microbiota provides important benefits to its host. However, disturbance of the microbiota-host relationship, promoted by genetic or non-genetic factors, can alter intestinal homeostasis and drive chronic low-grade intestinal inflammation, ultimately leading to metabolic abnormalities. We previously reported that a ubiquitous class of food additives, emulsifiers, detrimentally impact the microbiota resulting in its encroachment into the mucus layer that associated with low-grade inflammation and development of metabolic disorders. The central goal of this proposal is to investigate the hypothesis that bacteria that penetrate the inner part of the mucus layer, referred as invaders, promote development of metabolic alterations. We herein propose to identify mucus-invaders, in preclinical models and clinical conditions, and investigate mechanisms by which they promote inflammatory and metabolic abnormalities. Furthermore, we propose to define original approaches to modulate the intestinal microbiota in order to counteract microbiota encroachment and protect against associated metabolic abnormalities.

Keywords: host,microbiota interactions
C53 and Ufmylation Regulation In Endoplasmic Reticulum-Autophagy (ER-phagy) (CURIE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

Autophagy is a highly selective cellular quality control pathway. Selective removal of autophagic cargo are mediated by cargo receptors that contain cargo binding domains and ATG8 interacting motifs to bridge the cargo with autophagosomes. Although cargo receptors are the key players linking autophagy to cellular quality control, most of them are still waiting to be uncovered in plants. Identification and characterization of novel cargo receptors will pave the way for future translational studies that aim to enhance stress tolerance in crop species. The host lab recently identified an Endoplasmic reticulum (ER) autophagy receptor C53, that interacts with ATG8 via non-canonical shuffled ATG8 interacting motif. Besides, C53 is regulated by an enigmatic posttranslational modification called ufmylation through binding to another ubiquitin-like protein UFM1. Interestingly, ATG8-UFM1 interaction is mutually exclusive. However, the structural basis of C53-ATG8 or C53-UFM1 interaction are currently unknown. Also, the physiological roles of ufmylation and the ufmylated protein substrates have not been studied in plants. In this proposal, I aim to structurally and genetically characterize C53-ATG8 and C53-UFM1 interaction. In parallel, using proteomics, I will determine the ufmylome, i.e., ufmylated protein catalogue in plants for the first time. Finally, I will move beyond model species Arabidopsis and establish autophagy and ufmylation studies in rice. Altogether, my studies will further our understanding of a novel ER quality control pathway in model plant species and beyond. I will work at the Gregor Mendel Institute (GMI), Vienna BioCenter (VBC) in the lab of Yasin Dagdas. VBC is one of the largest life sciences hubs in Europe. It has a dynamic postdoc community, with structured training programs to prepare postdocs for independent careers. The cutting-edge research concepts, resources, and soft-skill training that I will gain will help me to establish my own lab.

Keywords: we use multiple biophysics and protemoics methods combined with plant genetics to dissect the role of ufmylation in er phagy regulation and cell homeostasis in arabidopsis and rice
Alliance for Family Integrated Care (FICare) Implementation in Neonatal Intensive Care Units (RISEinFAMILY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Türkiye,Zambia,Romania,Netherlands,United States,United Kingdom,Canada
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-09-01
End date: 2025-12-31
Duration (months): 52.0
Total project cost (EUR): 455400.0
EU funding (EUR): 446200.0
Participants: 13
Project status: SIGNED

Preterm births are the major cause of infant mortality in both developed and developing worldwide countries and one of the main concerns of public health systems. Very low birth weight infants and new-borns who suffer severe acquired diseases, congenital malformations or rare diseases face similar burdens and challenges. Altogether can be referred as “high-risk neonates”. These neonates have to spend long periods at Neonatal Intensive Care Units (NICUs) and, even so, they are at risk of developing short- and long-term health problems. This fact provokes suffering (e.g. anxiety, stress or trauma) to high-risk neonates’ parents and stressful situations, including burn-out, to NICU clinical staff. To overcome this, a Family Integrated Care (FICare) model that involves parents as primary caregivers in NICU teams has been recently developed with very promising results. RISEinFAMILY, a 52-months research project, aims to undertake an implementation study of the FICare model to make it suitable to all environments (no matter the country or the NICU) and set it as the new international standard of neonatal and family care. A geographical, social and cultural diverse consortium composed of 12 partners from 4 high- (ES, NL, UK, and CA), 2 middle- (RO and TR) and 1 low-income (ZM) countries will scale-up and adapt the FICare model for the first time in Europe, Africa and Asia. About 2800 infants will be assessed and clinical staff and families from at least 1600 high-risk neonates trained and educated for enrolling in 7 pilots worldwide (5 in non-FICare and 2 in FICare NICUs). Using mixed-methods research, the project will assess the impact of RISEinFAMILY in infants’ health (during NICU admission and after discharge), families and healthcare professionals experience from a psychological perspective and the socio-economic sustainability. Project outcomes will be promoted for stakeholders’ engagement and an appropriate strategy for exploitation of results will be defined.

Keywords: nicu,ficare,family integrated care,high risk neonates,parents,nursing,family,perspective,humanization of care,training,cost effectiveness,value of implementation,equity
Technologies for Autonomous Rail Operation (TAURO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Italy,Germany,Switzerland,Belgium,France,France,Czechia
Call: Advanced Functions towards Autonomous Trains (H2020-S2RJU-CFM-2020, 2020)
Start date: 2020-12-01
End date: 2023-05-31
Duration (months): 30.0
Total project cost (EUR): 2770374.8
EU funding (EUR): 1955260.76
Participants: 24
Project status: SIGNED

The high-level objective of TAURO is to identify, analyse and finally propose suitable founding technologies for the future European automated and autonomous rail transport, to be further developed, certified and deployed through the activities planned for the European Partnership for Transforming Europe’s Rail System. To achieve this, TAURO is divided into four technical WPs, following the scope of the call, that each deal with separate system elements, with each contributing to the overall goal of the project. These four areas of work are; • Environment perception for automation • Remote driving and command • Automatic status monitoring and diagnostic for autonomous trains • Technologies supporting migration to ATO over ETCS These technical WPs will be supported by a comprehensive dissemination and exploitation WP that will guarantee the results from TAURO are communicated to the necessary stakeholders, standards and regulatory bodies to ensure that the future policy and technical decisions are taken on the basis of the science and research performed in TAURO, and more important, who guarantee the coherence with other Shift2Rail ongoing activities and assure a seamless bridging between TAURO and the next initiative within Horizon Europe, Transforming Europe’s Rail System.

Keywords: autonomy,adas,environment perception for automation,remote driving and command,automatic status monitoring and diagnostic for autonomous trains,ects
A Novel Method to Reduce Industrial Dust Pollution of Respirable Air (DUSTCOMB)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Finland
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A spin-off from University of Oulu (Finland), Filtra Group Oy, has developed a revolutionary industrial dust extraction technology that gives 90% cost reduction compared to current state-of-the-art solutions. Our DustComb system addresses directly the urgent need for various industries (e.g. power plants, metals processing plants, etc.) to meet new air quality regulations that demand better extraction of particulate matter from the industrial emissions. Today, various emission regulations affect around 200,000 industrial units globally that need to comply with new emission norms by installing advanced filtration units in the coming years or close their operations. DustComb has been already validated in operational tests in SSAB steel plant and the results confirmed that our innovative fluid dynamics phenomena based technology meets all required emission standards. In addition, DustComb´s excellent cost-efficiency ratio, retrofitting compatibility, wide operating temperature tolerance, unique heat exchange feature, low maintenance costs, and other key benefits will ensure us fast market uptake globally. We have already reached to preliminary agreements with several potential clients in Europe and Asia via our industrial partners SSAB and Siemens VAI. We will generate our revenue from DustComb units’ sales and regular maintenance. By 2020, we plan to reach annual installation capacity of 400 DustComb units, which leads to approximately €100 million turnover and 300 new jobs. Today, we have secured all necessary resources and experienced team to finalize our technology development and evolve to sales-oriented emission control solutions provider. As a result of the SMEI phase-1 project, we have analysed the feasibility of our business, manufacturing and commercialisation plan and have prepared a detailed roadmap for 2017-2020. The result of the phase-1 project helps us to seek additional funding both from EU-programmes and from other investors.

Keywords: industrial emissions,air quality
Functions of Integrins in Mammary Stem Cell Activity and Tumorigenesis (INTEGRISTEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Understanding the functional interactions between mammary epithelium and its microenvironment, with a particular focus on the stem cell niche, represents a challenge for developmental and cancer biologists. Mammary epithelium is a bilayer, with a layer of luminal cells, producing milk, and a layer of basal myoepithelial cells. Both layers contain clonogenic stem/progenitor cells, which ensure the drastic epithelial expansion in puberty and pregnancy. Whilst basal stem cells are thought to be bipotent, luminal progenitors appear to be lineage-restricted in normal gland. Recent studies indicated that basal-like breast tumors, notably those with BRCA1 mutations, might originate from luminal progenitors. Our project aims to elucidate the role of integrin receptors for Laminin, major component of the mammary basement membrane, in the regulation of the luminal progenitor function during normal mammary development and tumorigenesis. To this end, α3 and α6 integrin chains were deleted from mammary luminal cells in vivo using CreLoxP system. Cre expression was driven to luminal progenitors by the Blg promoter, activated in this cell population in adult virgin mice and further on, during lobulo-alveolar development in pregnancy. The stem cell activity and the maintenance of the stem cell populations in mutant mammary glands will be analyzed at different developmental stages. Morphogenesis, proliferation, survival, differentiation as well as the regenerative and clonogenic potential of the mutant epithelium will be examined. We will study the cytoskeleton organization and the capacity of mutant cells for baso-apical polarization. To analyze the responses of integrin-depleted cells to hormones and growth factors at the molecular level, organotypic ex vivo cultures will be employed. The impact of Laminin-binding integrins on abnormal luminal progenitor amplification during tumor initiation will be tested in a mouse model of basal-like breast cancer induced by p53 and BRCA1 loss.

Keywords: mammary gland,integrins,laminin,stem and progenitor cells,mouse models of breast cancer