Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Inflammation and AD: modulating microglia function focussing on TREM2 and CD33 - Sofia ref.: 115976 (PHAGO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Italy,Sweden,Switzerland,Belgium,Finland,Sweden,France,France,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: Inflammation and AD: modulating microglia function – focussing on TREM2 and CD33 (H2020-JTI-IMI2-2015-05-two-stage, 2015)
Start date: 2016-11-01
End date: 2022-04-30
Duration (months): 66.0
Total project cost (EUR): 18221231.46
EU funding (EUR): 8838000.0
Participants: 21
Project status: CLOSED

Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disease with four main pathological changes in the brain: amyloid plaques, fibrillary tau tangles, inflammation and neuronal loss. Phagocytes around amyloid plaques in late onset AD (LOAD) may be neurotoxic but have limited motility and phagocytic activity, suggesting a dysfunctional activation. These phagocytes express the innate immune receptor TREM2 and CD33. Variants of both genes have been linked to LOAD. The main objectives of PHAGO are to find means of modulating microglia/macrophage activation via TREM2, CD33 and related signalling pathways, and determine the effects of such modulation on microglia/macrophage function, amyloid-β and neurodegeneration, in order to find a treatment for AD. PHAGO will deliver well characterized tools and knowledge through which to manipulate AD risk and provide targets and markers ready to progress to drug development. PHAGO will realise this goal by comprehensively attacking the problem simultaneously at multiple levels, including the molecular structures of the receptors, receptor ligand interactions, ectodomain function in vitro and in vivo, characterisation of receptor processing, modification and signalling, receptor-regulated signalling pathways, gene expression and phagocyte function in cells and animals, comprehensive analysis of receptor knock-in and knock-out models crossed to two different animal models of AD, and identification of receptor-related biomarkers in AD patients. Innovative approaches of PHAGO will include identification of new AD-risk genes using a TREM2 co-expression network approach, brain imaging of AD patients with TREM2 and CD33 variants, and generation of patient iPSC-derived microglia/macrophages to comprehensively phenotype gene variants. The project will also generate tools, such as ligands, reporter cells and optimised assays, suitable for further development of treatments targeting TREM2 and/or CD33 in AD.

Keywords: alzheimer,neuroinflammation,neurodegeneration,load,trem2,cd33,microglia,amyloid beta
Emergent Biopolitics of Kinship, Gender and Reproduction: Trialogues from the South (TRIALOGUES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Brazil,Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2022-02-28
End date: 2025-02-27
Duration (months): 36.0
Total project cost (EUR): 237768.0
EU funding (EUR): 237768.0
Participants: 2
Project status: SIGNED

TRIALOGUES is an interdisciplinary research project on emerging biopolitics of kinship, gender, and reproduction. It focuses on path-breaking processes of legal innovation and concomitant political backlashes taking place in Brazil, Spain and Portugal in order to offer a singular comparative approach and to provide empirically informed theoretical insights that are relevant for ongoing debates in the intersections among gender and queer studies. Rooted in the field-defining works of moral and political philosophers, recent feminist scholarship and queer theorists have shown the need for interdisciplinary approaches to biopolitical studies. Drawing in this dense intersection between social sciences and the humanities, the proposed research focuses in three countries pertaining to the European and the global south whose recent history is marked by the transition to democratic regimes in which profound transformations of the biopolitics of kinship, gender and reproduction took place over a rather brief period of time. In this sense, the proposed research constitutes an original response to influent criticisms coming from sexuality studies urging a de-centering of the academic focus away from the global north in order to retain the very political impulse of field-defining concepts such as sexual and intimate citizenship. More specifically, the project comprises one main strand to be conducted in Brazil –the country of primary focus– and 2 complementary strands in Spain and Portugal, where research will be enabled through secondments. All three strands are aimed at producing empirically informed discussions of emerging biopolitics with an emphasis in the state logics (e.g. political institutions, social policies, legislative and judicial provisions) involved in the overlapping fields of kinship, gender and reproduction as they unfold through emerging regulations of non-monogamous relationships, gender identity and third-party assisted reproduction.

Keywords: biopolitics,feminist and queer bioethics,non monogamies,gender identity,gestational surrogacy,conservative backlash,public order,global south,southern europe
A Social Identity Model of Trauma and Identity Change: A Novel Theory of Post-Traumatic Stress, Resilience and Growth (SIMTIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Ireland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2493707.5
EU funding (EUR): 2493707.5
Participants: 1
Project status: SIGNED

This project will develop a new social paradigm for trauma research that will allow us to understand post-traumatic stress and facilitate post-traumatic resilience and growth. This new paradigm holds that changes in social identities – the sense of self we derive from being part of valued groups – are at the heart of post traumatic outcomes. This breakthrough project will develop a synergistic model explaining how physiological, clinical and socio-political consequences of stress and trauma result from changes in the nature, extent and quality of social identities. Ground-breaking theory will be supported by ground-breaking methods. (1) Changes in group membership and identification and identity resources will be linked to objective measures of stress and trauma. Since, to date, emerging evidence of health benefits of group memberships and social identities have largely been demonstrated using subjective measures, this methodological advance is both novel and important. (2) Causal effects of positive and negative change in social identities on stress and trauma outcomes will be examined using longitudinal and experimental approaches, working in both laboratory and community contexts. (3) Qualitative studies will explore whether changes in social identities are associated with post traumatic growth at the personal level as well as the novel idea that trauma can effect change and growth in social identities. (4) Finally, a large scale survey will assess whether trauma, via enhanced social identification, can drive progressive social change. This new paradigm will transform the conceptualization of trauma from individual to social; deepen our understanding of the physiological and psychological implications of stress and trauma; and link the personal effects of stress and trauma to its wider social and political consequences.

Keywords: social identity,intragroup processes,group behavior,social identity change,collective behavior
The Role of Local Protein Degradation in Neurotransmitter Release and Homeostatic Plasticity (SynDegrade)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1489340.95
EU funding (EUR): 1489340.95
Participants: 1
Project status: CLOSED

While many neurons live for decades, the proteins that determine neural function have half-lives of hours to weeks. On the one hand, this allows for plastic changes during development and learning. On the other hand, this poses the question of how stable neural function can be achieved and maintained at all. Several neurological diseases, such as epilepsy or migraine, have been linked to uncontrolled neural function. However, the molecular mechanisms that stabilize nervous system function are poorly understood. The major site of regulation of neural activity is the chemical synapse. Synaptic function is tightly linked to the specific composition and abundance of proteins at synapses. However, the molecular pathways underlying the homeostatic control of protein levels at synapses, henceforth called synaptic proteostasis, are largely unknown. The main objective of this proposal is to unravel the molecular signaling systems underlying synaptic proteostasis through local protein degradation, and its role in regulating a key step in synaptic transmission: neurotransmitter release. We propose to systematically analyze Ubiquitin Proteasome System (UPS)-dependent modulation of synaptic transmission in mutants of all major classes of synaptic genes, with a focus on homeostatic plasticity genes. This will be realized by employing a unique combination of forward genetics and electrophysiological analysis of synaptic transmission in Drosophila. Novel genetically-encoded probes will be used and developed to study synaptic transmission and protein degradation, and to acutely perturb protein function. Finally, this new information will be translated into the mammalian CNS by studying UPS-dependent modulation of release at a CNS synapse that allows for a detailed biophysical description of this phenomenon. Together, this approach should be ideally suited to dissect the molecular signaling systems underlying presynaptic proteostasis, and its role in neural physiology and pathology.
Soakback Assessment using LAttice Boltzmann Method and Aerothermal Nodal-network for the Design of the Engine-bay Region (SALAMANDER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,France
Call: Aerothermal characterization in the engine compartment (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2021-12-31
Duration (months): 46.0
Total project cost (EUR): 824873.75
EU funding (EUR): 824873.75
Participants: 4
Project status: CLOSED

As part of H2020 program, CleanSky II aims at pushing forward the whole EU aeronautical sector to a worldwide prominent place as well as addressing ambitious targets in reduction of pollution and fuel consumption. Within the “Sustainable and Green Engine” Integrated Technology Demonstrator, WP 3 Business Aviation / Short Range Regional TurboProp Demonstrator aims to bring to market a new generation of TurboProp. The present call JTI-CS2-2017-CFP06-ENG-01-21, associated with WP3.5.3 Engine nacelle Demonstrator and WP3.6.1 Thermal Management, ultimately aims at assessing the temperature inside the Engine Bay of an ARDIDEN3 TurboProp during soak-back. The projects deploys in 3 phases. First, perform high-accuracy, state-of-the-art LBM simulations, of the full engine. Second, develop a reduced-cost, Nodal-network model, for the channel region. Finally, combine LBM (accuracy) & Nodal methods (reduced-cost) to assess soak-back at acceptable cost in the TP Demonstrator. Challenges are numerous: Physical (Free Convection/ High Mach numbers); Modeling (LBM/ Nodal Network Coupling); Computational (Long-Transient/ Engine Geometry/ 3D Fluid & Solid). The highest levels of numerical expertise are required. The present proposal, SALAMANDER “Soakback Assessment using LAttice Boltzmann Method and Aerothermal Nodal-network for the Design of the Engine-bay Region”, offers cooperation between EXA, world-leader in LBM solutions, and ALTRAN, world-leader in Engineering Solutions, Fluid and Thermal Engineering Expertise Center. The Call combines EXA powerful LBM software, with an expertise on Soak Back, to ALTRAN expertise in Aerothermal and Nodal modeling. This strong partnership ensures this Call success. Eventually, the outcome model delivery will allow the Topic Leader to improve the design of the TurboProp demonstrator as well as future products. Finally, EU industrials and environment shall greatly benefit from this study, thanks to ALTRAN and EXA new Engineering offers.

Keywords: soakback,aerothermal,nodal modelling,engine,turboprop
Defect Engineering, Advanced Modelling and Characterization for Next Generation Opto-Electronic-Ionic Devices (OptEIon)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany,Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1980735.0
EU funding (EUR): 1980735.0
Participants: 2
Project status: SIGNED

Defects in semiconductor materials commonly deteriorate the performance of optoelectronic devices such as solar cells and light-emitting diodes. In the recently emerged and highly successful hybrid metal halide perovskite, some lattice defects are even mobile leading to mixed ionic-electronic conductivity. This and other outstanding properties (tunable bandgap, lower dimensional embodiments, solution processability) make the perovskite a very interesting material for research and application. At the same time, it suffers from various degradation processes, linked to these poorly understood ionic defects. The major questions are: Where and what are these defects? How are they formed and how can we control their movement? OptEIon will provide answers to these questions. Based on my expertise in the device physics and experience in perovskites I will proceed as follows: First, I will characterize the transient response of devices with different perovskite materials, different stoichiometry, partial pressure of constituents, temperature, etc. to find clear evidence for the nature of the mobile defects and their diffusion constant. Second, I will employ nano-scale characterization on cross sections of working devices to measure location and time evolution of defects causing recombination losses in solar cells. In addition to established measurement techniques, I will use tip-enhanced (near field) spectroscopic techniques, which can provide super-resolution imaging. Third, I will apply device simulation to examine the measurement results. I will furthermore evaluate how machine learning in combination with our physical model could be implemented to help analyse device data. Fourth, I will exploit the results by fabricating demonstrator memristor arrays that can be controlled by light. The outcome will be more efficient and stable solar cells and novel optoelectronic devices such as memristors, which are supposed to herald a new era of neuromorphic computing.

Keywords: perovskite,defects,ionic electronic conductivity
LaminarPace System: a breakthrough technology for dry-formulation of sensitive pharmaceuticals at room temperature enhancing their stability beyond the cold chain (FORMBECC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Formulation of sensitive drugs in a stable manner poses problems with currently applied technologies: the substances need to be either heated up to +80 °C or frozen to -80 °C. Many valuable biological pharmaceuticals need to be kept and transported in a liquid phase at fixed temperatures, which renders them impractical and costly. The global healthcare community, with the World Health Organisation in the lead, is looking for options to step out of the cold chain and provide more accessible medication to all communities. In the LaminarPace project, Ziccum AB is developing a gentle, room temperature spray-drying technology for the application in the pharmaceutical industry. The system is operational on a laboratory scale and pilot-tested now. It could successfully lead to the development of new biologics: vaccines, drugs and therapies. An industrial-scale system based on the same principles of operation will be developed and commercialised. The objective is to set the large system into BioTech production lines. LaminarPace process is fully controllable according to Good Manufacturing Practice and produces carefully-engineered, stable and easily-absorbed formulations.

Keywords: spray drying,drug formulation,controlled temperature chain,drug stability,micronisation,particle engineering
Advanced Innovation Service Support for SMEs (AISS4SME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Luxembourg
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 149031.25
EU funding (EUR): 149031.25
Participants: 3
Project status: CLOSED

The AISS4SME project aims at offering new services to enhance the innovation management capacities of luxembourg SMEs. 2 target group of SMEs will be address : first, the beneficiaries of the SME instrument and, second, innovative SMEs. This proposal is a response to the topic “INNOSUP-2014: Establishing services “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network”, and concerns the set up of coaching and mentoring services for SMEs. It’s our confidence that the AISS4SME proposal is 100% in line with the challenge and scope defined by the EC. Moreover, by pursuing the defined strategic objectives, the project will automatically produce the expected overall impact of: • Enhancing the commercial potential and impact of SME participation in the dedicated Horizon 2020 instrument by ensuring that the project is aligned with and developed as an integral part of the company's innovation strategy, • Achieving tangible organizational change and improved results, • Improving the skill's levels of managers, leaving a legacy such that the SME is better able to overcome the barriers to growth post-Horizon 2020 participation.

Keywords: innovation management capacity,key account management,smes
Holographic lattices and quantum phase transitions (HLQPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-09-20
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The anti de-Sitter/conformal field theory (AdS/CFT) correspondence has provided a new inter-disciplinary way to the study of strongly coupled systems and has an impact in various areas in physics, including quantum field theory, hydrodynamics, QCD, condensed matter physics, quantum information, etc. In this proposal we focus on the application of AdS/CFT to condensed matter theory (AdS/CMT), which is an inter-disciplinary subject combining gravity, string theory and condensed matter physics. As a fast developing field AdS/CMT has had a lot of achievements and also attracted the interest of many condensed matter physicists. To apply AdS/CMT to the real world condensed matter systems, we need to encode translational symmetry breaking in holography, which makes it important to construct and understand holographic lattice systems. A lot of success has been obtained in this direction and people even found very similar behaviour of optical conductivity in holographic models to that of cuprates in experiments. However, the current study of holographic lattice systems is not adequate when we want to investigate deeper into the cuprate phase diagrams and describe the more complicated and realistic lattice structures with broken lattice symmetry. In this proposal we aim to find the holographic descriptions of incommensurate and commensurate phases and study the transport properties and phase diagrams, especially quantum phase transitions to gain more insight into the understanding of cuprates and the deep reason of why some holographic models are able to produce the same behaviour of optical conductivity as in strange metals.

Keywords: cft correspondence,holography,gravity,general relativity,translational symmetry breaking,optical conductivity,phase transitions