Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elucidating the interplay between nuclear compartments and transcriptional dynamics during differentiation (DynaDiff)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1498372.0
EU funding (EUR): 1498372.0
Participants: 1
Project status: SIGNED

Development is driven by transcriptional programs where specific gene regulatory networks (GRN) control genes on several time scales. However, the extent to which transcriptional dynamics are coordinated for different genes and how the differential downregulation of the progenitor GRN determines cell fate remains poorly understood. This in part due to the difficulty of measuring genome-wide transcription with temporal resolution in complex developmental systems. Plus, transcription occurs in the nuclear context, where the nucleoplasm is compartmentalized into a variety of highly dynamic condensates known as membraneless organelles (MLOs), which include nucleoli, PML (promyelocytic leukaemia) nuclear bodies (PML-NBs), and nuclear speckles (NSs). The homeostasis of these MLOs changes during differentiation, but their impact on transcription and lineage commitment remains elusive. In DynaDiff, I aim to investigate the link between PML-NBs and NSs and transcriptional regulation during mammalian differentiation by: 1) developing single-cell RNA sequencing (scRNA-seq) methods to characterize transcriptional dynamics in mouse and human embryonic stem cells (m/hESCs) during the exit from pluripotency; 2) determining the role of PML-NBs and NSs on transcriptional dynamics during differentiation, and 3) assessing the role of PML-NBs and NSs in organizing chromatin conformation and its link to active transcription. I recently made a significant technological breakthrough, finally bringing long-awaited temporal resolution to scRNA-seq. This expertise, in combination with my background in high-throughput microscopy and computational analysis allows me to lead and conduct DynaDiff successfully. Finally, hESCs have the potential to form cell types from the three primary germ layers. Our knowledge of this system is paramount to understand human early embryonic development for the treatment of developmental disorders, and for the development of regenerative medicine.

Keywords: membraneless organelles,chromatin conformation,single cell transcription,deep learning
Non-Hermitian topological systems and their applications for sensors (NHTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Non-Hermitian topological systems have emerged as a promising area of study within condensed matter physics, garnering substantial attention in recent years. Their distinct characteristics, including the non-Hermitian skin effect and their potential applications in sensing technologies, have spurred a surge of interest and investigation. This research proposal outlines a comprehensive program aimed at studying non-Hermitian systems and exploring their practical utility in the development of innovative devices. The research program is structured around two primary branches, each addressing critical aspects of non-Hermitian systems. The first branch seeks to develop a robust theoretical tool for comprehending and predicting non-Hermitian skin effects in disordered systems, particularly in higher than one dimension. For this wave packet dynamics will be used as a method. As part of the program, a comprehensive code package will be produced, facilitating access to these simulations for fellow scientists and researchers. The second branch of this program focuses on the theoretical development of mechanical metamaterial devices capable of studying non-Hermitian matrices. In stark contrast to conventional approaches, where the dynamical matrix of the system is designed to be non-Hermitian the aim is to engineer systems where the response matrices to external drive exhibit non-Hermitian characteristics. This idea builds on recent research findings where such systems have been successfully realized by us in conductance matrices. Extending this approach to mechanical metamaterials, offers a versatile and rapidly deployable platform. Collaborative efforts with experimentalists will play a pivotal role in the actualization of these novel devices, poised to advance the frontiers of applied non-Hermitian physics.

Keywords: non hermitian topology,exceptional points
Human-Centric Artificial Intelligence for Sustainable Future (HAIF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Finland,Sweden,Italy,Belgium,Germany,United States,Estonia,France
Call: MSCA COFUND 2023 (HORIZON-MSCA-2023-COFUND-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 3360000.0
EU funding (EUR): 3360000.0
Participants: 19
Project status: SIGNED

For the EU to strengthen its role as the global leader in trustworthy AI, experts on ethical, human-centric and sustainable use of AI are urgently needed in public, private and third sector organisations across member states. This interdisciplinary expertise is not readily available through traditional doctoral training frameworks. The fast-evolving field will continue to create opportunities for individuals with resilience and future-proof skills. Human-Centric Artificial Intelligence for Sustainable Future (HAIF) is a doctoral programme for 25 doctoral candidates (DCs) hosted by the University of Turku (UTU), Finland, and supported by 17 associated partners. HAIF will establish a novel doctoral training scheme that connects UTU’s Faculties of Technology, Social Sciences, Law and Humanities. HAIF’s research themes are societally relevant, emphasizing humans as developers, users and decision-subjects affected by the technology. In addition to individual and societal perspectives, HAIF produces technological solutions for improved safety, security, interpretability and technical robustness of AI systems. Research on application areas such as health care, autonomous systems and cybersecurity will be transferable to different sectors. HAIF’s academic collaboration network covers 7 EU countries and the U.S. 6 non-academic partners bring in business relevance and views of the public administration. Besides enhancing DCs’ academic skills and producing new interdisciplinary knowledge, HAIF will train DCs on transferable skills such as communications and project management, which are essential for widening their career prospects. HAIF DCs will be selected through a transparent, merit-based process with equity and inclusivity as cross-cutting priorities. By training the future professionals in the critical themes of human-centric and sustainable AI, HAIF increases competitiveness, jobs and growth from the regional to EU scale.

Keywords: sustainable ai,trustworthy ai,safe ai
Towards materials at extremes: from intense dynamic compression to expansion (DYNPRESS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1496873.0
EU funding (EUR): 1496873.0
Participants: 1
Project status: SIGNED

The project aims at developing robust, reliable and effective techniques for generation of extreme conditions. Positive TPa as well as negative MPa pressures in liquids will be produced with limited resources available in everyday research environment. The project offers a unique integration of approaches and resources in high voltage engineering and plasma physics applications towards classical problems of compressible fluid mechanics. It investigates by experiment, computation and theory the major physical properties of imploding shock waves in liquids and offers approaches to enhance efficiency of the focal energy concentration. The project develops a novel method for generation of imploding rarefaction waves, a well controlled scenario that provides with exactly opposite range of extreme conditions, namely negative pressures in liquids. The approaches comprise a single generator facility that opens research on a broad spectrum of basic-to-applied subjects, promising a long-term investment towards studies of materials at extremes. The facility is applied on a selected subject of mechanical treatment of cellulose fibers, aiming at enhancing the efficiency of fibres disintegration, homogenization and fibrillation processes by applying, both selectively and combined, compression and tension pulses on a broad range of intensities, from strong to extreme.

Keywords: shock wave,implosion,rarefaction wave,expansion,extreme conditions
Systematic autonomous remote surveying of underwater cultural heritage monuments and artefacts using non-destructive, cost-effective and transportable digital solutions (NERITES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Germany,Cyprus,Greece,Italy,Switzerland
Call: Advanced technologies for remote monitoring of heritage monuments and artefacts (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3994750.0
EU funding (EUR): 3994750.0
Participants: 13
Project status: SIGNED

The proposition in this project is to use autonomous platforms for remote monitoring and chemical mapping of underwater heritage sites, such as AUVs (Autonomous Underwater Vehicles), BUOYs (Unmanned Surface Vehicles) and ROVs (remote operated vehicles). A swarm of self-coordinated AUVs will be responsible to monitor, survey and scan the heritage sites for detecting/identifying and monitor degradation, state of the UW surrounding site, possible intervention actions for alarming conditions etc. The swarm of AUVs will embed high edge processing capacity to support operational autonomy, dynamic path planning, dynamic sample-strategy planning and coordinated-swarming towards overall low energy consumption and long mission endurance, according to the project mission goals. The proposed swarming concept foresees building common underwater consensus of the cultural site, through periodic bilateral communication between AUVs to mutually achieve the overall common surveying goal; while the mother BUOY will be responsible to collect and deeply analyze raw AUV information to provide enhanced site situation awareness insights to the external human supervisor/user. Furthermore, the BUOY will be equipped with renewable solar collectors to ensure continuous power availability and reduced mission’s footprint, enough to support the overall mission energy needs (AUV will be periodically powered through BUOY). The supervisor/user will be located in a remote monitoring station, onshore, to allow periodic mission lifecycle management and general overview of the whole system situation based on real-time visual analytic mechanisms

Keywords: remote monitoring,autonomous underwater platforms,underwater sensing
Flexible Approaches to Support Health through financing (FLASH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Italy,Czechia,Netherlands,Spain,Germany,Lithuania,Poland,Austria,Belgium
Call: Better financing models for health systems (HORIZON-HLTH-2022-CARE-08, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4956806.12
EU funding (EUR): 4956805.87
Participants: 18
Project status: SIGNED

One of the lessons learnt from the Covid-19 pandemic is the importance of flexibility in funding and organization of health systems. European countries responded quickly to this extreme event, by expanding the amount of financial resources available for health care and reallocating financial and human resources. However, there are several other challenges for health care systems that require efficient and flexible financing mechanisms to be successfully addressed. This project undertakes a comprehensive analysis of health care financing mechanisms in Europe, by focusing on the two key stages of the process: i) budget allocation (e.g., among managing authorities, clinical areas), ii) financing of health services within a specific budget, through the definition of contracts and payment rules. We identify and examine the most prominent mechanisms underlying the relationship between the main challenges faced by health care systems (demand shocks, ageing, budget pressure) and their financing. By employing a wide range of methodological approaches, we provide evidence on the ability of existing financing mechanisms and contracts to address such challenges and study new solutions to achieve more effective, efficient and equitable health care systems.

Keywords: financial allocation criteria,pay for performance,resilience,integrated care,digital health,patients mobility
Sensing ENdometriosiS On Portable Auxiliary Devices (SENSOPAD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Greece,Denmark,Spain,Belgium,Cyprus,Italy,Portugal,Israel,United Kingdom
Call: Smart sensors for the Electronic Appliances market (RIA) (HORIZON-CL4-2023-RESILIENCE-01-TWO-STAGE, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 8257999.43
EU funding (EUR): 6891176.39
Participants: 14
Project status: SIGNED

SENSOPAD initiative heralds a transformative era in women's health by addressing the longstanding challenges posed by Endometriosis (ED). ED's early detection is often underdiagnosed due to its asymptomatic nature, pivotal for improved health outcomes and reduced healthcare costs. SENSOPAD introduces two pioneering ED sensing systems: sensoPAD, seamlessly integrated into sanitary pads, and sensoMFgFET, a portable Point-of-Care (POC) device. SensoPAD comprises three Biological Processing Units (BPU) - BPU-1, BPU-2, and BPU-3 - ensuring continuous monitoring. BPU-1 combines an electrochemical sensor with RFID, while BPU-2 merges a chemical-based fuel cell with an electrochromic cell. BPU-3, an energetically autonomous unit, synergizes BPU-1 and BPU-2 capabilities for seamless monitoring. SensoMFgFET, a POC device, utilizes microfluidic systems and bio-conjugated gFET with RFID functionality, capturing specific DNA SNPs from the menstrual fluid as early ED indicators. Both devices are complemented by a user-friendly mobile application enabling real-time data acquisition and analysis. An advanced cloud platform integrated with AI enhances diagnostic accuracy. This innovative approach shifts the paradigm in ED detection, empowering women, clinicians, and healthcare systems. SensoPAD detects biomarkers, providing insights during menstrual cycles. If concerns arise during its use, users transition to sensoMFgFET at clinical points, combining at-home convenience with clinical precision. SENSOPAD aims to reduce ED diagnosis time from eight years to days, enabling early treatment, preventing symptom deterioration, optimizing infertility care, and streamlining healthcare journeys. Integrating SENSOPADs with a mobile app and AI-enriched cloud platform ensures accurate, cost-effective diagnostics, detecting silent instances of ED, and signifies a paradigm shift, fostering informed, proactive, and inclusive healthcare decisions for women worldwide.

Keywords: endometriosis,point of care,medical device,wearable,graphene field effect transistor,gfet
Innovative methodology for battery testing (THOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: France,Belgium,Greece,Italy,Austria,Spain
Call: Digitalisation of battery testing, from cell to system level, including lifetime assessment (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 4915350.5
EU funding (EUR): 4915350.5
Participants: 9
Project status: SIGNED

Acceleration of growth of the battery sector is primordial in decarbonizing our economy as batteries play a vital role not only in making our mobility sustainable but also in increasing the uptake of renewable energies. Growth and particularly innovation in this sector are predominantly hindered by costly and time-consuming test protocols and methods that require large number of samples and sophisticated infrastructure. A battery concept generated in 2023 may at best reach the production stage in 2032 as performance, ageing and safety characteristics of the design must be assessed through a lengthy trial-and-error based physical testing. THOR aims to shorten this timeframe, diminish the number of physical tests and nurture innovation in battery conception by developing a virtual tool - a Digital Twin that simulates battery behavior. The project will target mobility and stationary applications and will focus on commonly used battery chemistries (representing 60% market share before 2030). Through an interdisciplinary approach involving experimentalists and modeling experts, 3 independent physics-based models for performance, lifetime and safety will be developed. The 3 models will then be combined and optimized using AI based approach to form a holistic digital twin of cell, module and pack. The digital twin will be accessible to the end-users through an efficient, user-friendly interface. THOR’s consortium covering the entire battery value chain will ensure that the project responds to the needs of battery industries (4 industrial partners including cell/ battery manufacturers and end-users) while enriching knowledge of the research community (3 research and technical organizations). In addition, the consortium aims to answer two requirements of the battery community: data harmonization and standardization of methodologies through the project. Ease-of-use, cost-effectiveness, rapidity and adaptability of the Digital Twin will be demonstrated by end-users.

Keywords: battery performance,battery lifetime,battery safety,modeling,digital twin,digitalisation,battery testing,testing methodology,physics based model,hybrid models,virtual tool
Tunable Charge Injection Layers for Organic Semiconductors (TILOS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

In recent time, light weight, flexibility, low-cost and tunability of organic semiconductors (OS) have drawn the attention of a broad scientific community and semiconductor industry, making them usable in many applications such as active-matrix organic light-emitting diodes (OLEDs) in smartphones, organic field-effect transistors (OFETs), solar cells, memories, photoswitches and sensors. Therefore, tremendous effort has been made to improve OS functionality. The development has reached the point where the contact resistance with the metal electrode, especially in OFETs, is becoming the main parameter limiting the performance of OS-based devices. Recent research in the Host Group has revealed that molecular monolayers (MoMs) composed of aromatic carboxylic molecules can be deprotonated on a silver substrate in a controlled manner. This finding opens a way towards developing entirely new highly efficient Charge Injection Layers for organic semiconductors. In this project I will employ state-of-the-art computational methods to characterize interfaces between Ag substrate and MoMs composed of aromatic carboxylic acid molecules, and design tunable CILs based on the controlled deprotonation. The project will go in hand with the experimental research carried out by the Host Group. If successful, our collaboration can help the OFETs finally reach their full market potential. My research will be carried out at CEITEC that offers the ideal set of equipment. The project will be supervised by Dr. Jan Čechal, an expert in experimental characterization of molecular interfaces, and co-supervised by Dr. Pavel Jelínek, an expert in molecular interfaces modeling.

Keywords: interface engineering,density functional theory,organic semiconductors