Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding parents' perspective on childhood disability. Strengthening expertise through qualitative validation of an explanatory model. (CDEVEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Iceland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-11-24
End date: 2017-01-19
Duration (months): 24.0
Total project cost (EUR): 145282.2
EU funding (EUR): 145282.2
Participants: 1
Project status: CLOSED

Objective The researcher's specific expertise in the sociological approach of disability issues will be placed within the larger framework of Disability Studies. More specific, his key competencies in childhood disability research will be further developed through qualitative validation in Iceland of his recently developed explanatory model for care-related decision-making in parents of congenitally deaf children. This will be guided by the following specific research objectives: (1)to investigate the relevance and importance of the different clusters and factors in the explanatory model, including addition of new relevant factors; (2)to assess the relations in the model between different clusters and factors, and to make additions/modifications where necessary; (3)to assess the implementation of the model for analysing parents’ experiences throughout the care trajectories within a specific national context – in casu Iceland. Implementation This research training project is based on qualitative data to be collected among Icelandic parents with a deaf child born 1998-2010, through 2 rounds of semi-structured interviews. Theoretical and methodological training will be centred around qualitative data analysis aimed at providing insight into how parents arrive at care-related decisions, which factors play a role in decision making and how these are interrelated. Also, using the model, the specific organisation of national early intervention services will be analysed. Scientific and career value Development of frameworks for sociological analysis of parents' perspectives in issues of childhood disability an important challenge in European disability research. This mobility proposal also enables the researcher to build on his an innovative explanatory model. The activities in this proposal will strengthen his expertise in development of middle-range theory in Disability Studies, innovative qualitative methodology, and management of networks of local stakeholders.

Keywords: disability studies,sociology of health and illness,care trajectories,childhood disability,parents' perspectives,decision making,deafness,early intervention programmes
Deciphering small RNA mechanisms during sexual reproduction in Arabidopsis (SRSR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-04-01
End date: 2015-07-29
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

Sexual reproduction is a key moment in many organisms’ life cycle that ensures the proper inheritance of traits and also allows adaptation. In both plants and metazoans, reproduction entails the complex coordination of gene expression between the different tissues involved. For example, intricate modifications of epigenetic landscapes occur during and around fertilzation to ensure zygotic totipotency while maintaining genome integrity. In recent years, key connections have been established between silencing small (s)RNA and reproduction with the discovery of piwi-associated small RNAs (piRNAs) in Drosophila. In the model plant Arabidopsis, a clear link exists between silencing sRNAs and the chromatin via de novo DNA methylation and Histone tail modifications, in a process referred to as RdDM. However, almost nothing is known about the involvement of sRNAs in the reproductive process. This project aims at filling this gap by studying sRNA-mediated mechanisms in tissues before and after fertilisation, i.e. in the plant germline and in the zygote. This proposal outlines a series of interdisciplinary and mutually reinforcing experiments to 1) Characterize the silencing machinery available during sexual reproduction in Arabidopsis; 2) Establish an unbiased developmental map of reproduction-associated sRNA; and 3) study the possible movement of sRNAs between and toward reproductive organs. The results are expected to shed a completely new light on plant reproduction and, more generally, might unravel novel sRNA-based regulations. The proposed project also has profound implications in agriculture as it may elucidate aspects of the poorly understood mechanisms underpinning hybrid vigour as well as intra- and inter-species compatibility. Finally, knowledge on cell biology, imaging and Arabidopsis reproduction biology implemented during the proposed project will contribute to European excellence and competitiveness in the field.

Keywords: l310 developmental genetics - embryology in plants,l206 molecular genetics - reverse genetics and rnai,l208 epigenetics and gene regulation,sexual reproduction
Stability of Non-Newtonian jets and implications for the onset of turbulence (NNJETS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-28
End date: 2015-10-27
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The manner by which fluid flows go from a laminar to a chaotic turbulent state is striking, and has significant biological, environmental and technological implications. As a result, a great deal of research effort has focused not only on studying transition to turbulence, but also on predicting and controlling its onset. To date, most of the advanced techniques for transition research have focused primarily on the ``pathways to turbulence" in Newtonian, or simple, fluids. These efforts, however, exclude a major class of flows, namely complex and non-Newtonian fluids, which are at the core of the pharmaceutical industry, oil and gas, and plastic and paper-making processes. The proposed research addresses this gap: a framework for the simulations of the linear and non-linear stages of instability in two-fluid, non-Newtonian flows will be established, and will be used to characterise and control transition in two-phase non-Newtonian jets, a flow configuration ubiquitous in the above technologies. The subject of the fellowship is innovative as the dynamics of non-Newtonian jets are less explored relative to their Newtonian counterpart. The latter have been the subject of recent advances in stability and direct simulation techniques, some of which were developed by the applicant. These recently developed methods are key to the design, optimisation and control of non-Newtonian flows which have numerous industrial and commercial applications. Furthermore, predictive capabilities and design tools for other transitional flows will improve, since the study of stability of non-Newtonian jets can be translated to a host of other shear flows. The fellowship will translate the candidate's expertise in advanced instability methods from Newtonian to non-Newtonian flows, will further the candidate's academic career, and will foster intra-European scientific exchange, such as a cooperation between Imperial College London and Swedish Royal Institute of Technology.

Keywords: g305 fluid mechanics - hydraulic- - turbo- - and piston engines,p216 fluid dynamics (physics),g304 computational engineering
Role of biofilm-matrix components in the extracellular reduction and recovery of chalcogens (BIOMATCH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 243847.8
EU funding (EUR): 243847.8
Participants: 1
Project status: CLOSED

The biogeochemical cycles of chalcogens play a major role in the environment, where the cycles of selenium (Se) and tellurium (Te) have been much less studied compared to those of the omnipresent elements oxygen and sulfur. Removal and recovery of Se/Te from wastes is desirable for ecosystem well-being and meeting future needs of these resources. To survive and grow, bacteria harvest energy by shuttling electrons to a variety of electron acceptors. Interestingly, a number of elements, including the Se/Te oxyanions are redox-active and can be used as electron acceptors by microbes. Thus, microbial metabolism alters solubility, thereby influencing transport, bioavailability and toxicity of the chalcogen oxyanions. In natural and engineered settings, biofilms are implicated in the transformation and immobilization of Se/Te. But, to develop industrial scale processes for removal and recovery, the rate must be accelerated. Identification of biofilm-components that mediate electron transfer to soluble Se/Te and solid-phase Se/Te might help to develop high-rate industrial scale processes. This IIF focuses on the identification of biofilm-components, exogenous electron shuttles that accelerate the reduction and recovery of Se/Te. A multi-disciplinary approach will be used for characterizing the reduction mechanisms, physiology and biofilm structure, thus the applicant acquires new skills available at the host institute. Experiments will be designed to find novel endogenous molecules, exogenous electron shuttles accelerating bacterial reduction of soluble Se/Te and solid-phase Se/Te. The fundamental insights obtained from the lab-scale studies will be translated to reactor-scale experiments for developing practical applications aiming at the removal and recovery as elemental Se/Te. The overall goal of this IIF is to train the applicant to develop more robust, economical and sustainable biotechnological processes for removal and recovery of Se/Te from industrial effluents.

Keywords: v407 environmental biotechnology - bioremediation-biodegradation,l817 biotechnology(non-medical)-bioreactors-applied microbiology,v201 biogeochemistry - biogeochemical cycles - environmental chemistry
Blocking the transmission of aphid-borne plant viruses (APHID-BORNE VIRUSES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-06-01
End date: 2014-07-31
Duration (months): 14.0
Total project cost (EUR): 152474.35
EU funding (EUR): 152474.35
Participants: 1
Project status: CLOSED

Plant virus diseases cause significant agricultural losses worldwide; most of these pathogens (three quarters) require a vector for spread. Despite the importance of such diseases, management is still largely based on the application of pesticides to control vector populations, which has direct and indirect consequences to food production and environmental safety and sustainability. Molecular determinants of vector transmission have been well explored only for a few plant disease systems compared to numerous animal diseases, and may represent an untapped source of novel disease control strategies. The goal of this project is to test if the transmission of important aphid-borne viruses can be blocked by disrupting molecular vector-virus interactions.

Keywords: aphid,plant virus,vector,transmission,disease,plant pathology,entomology,agriculture
Producing YXY FUELS from C6 carbohydrates using nanomaterials (YXY FS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-15
End date: 2016-01-14
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

The urgency to identify and develop sustainable and timely solutions for our future society has become clearly demonstrated due to the alarming trends in global energy demand, the finite nature of fossil fuel reserves, the need to dramatically curb emissions of greenhouse gases to mitigate the devastating consequences of climate change, the damaging volatility of oil prices (in particular for the transport sector) and the geopolitical instability in supplier regions. In this regard, I started to work since my postgraduated studies in to find alternative and greener methodologies in terms of materials preparation, production of biofuels (which can partially meet the future expected needs of our society in terms of energy for transport), (photo)catalysis as a greener alternative for the production of chemicals and energy as well as biomass and waste valorisation. Biomass from plant is the most important feedstock for food, feed and non-food applications. In the processing of plant materials e.g. wood for paper, substantial amounts of potentially valuable by-products are produced. In this regard, the host organisation, Avantium Chemicals BV, explores unique bio-refinery concepts on novel routes for C6 carbohydrates conversion using nanomaterials. The main objectives are: 1)To develop a range of new multifunctional catalysts (e.g. based on mesoporous silica materials with controlled acidity and metal nanoparticles loading), through synthesis, using a combination of novel techniques 2)To screen their reactivity using model reactions 3)To develop an approach for testing selected catalysts using real feeds from e. g. the pilot plant 4)To optimise the reaction conditions (with emphasis on the reduction of energy consumption aand waste production), evaluation of the catalyst stability. 5)To integrate my knowledge and experience in heterogeneous catalysis into the Avantium R&D environment. In order to achieve these ambitious goals, I will use an interdisciplinary approach.

Keywords: nanomaterials,heterogeneous catalysis
Fundamentally new strategy for coupling of secondary alkyl boronic esters for the formation of new C-C bonds (FUNTASTIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The formation of new carbon-carbon bonds is of central importance in organic chemistry and a prerequisite for all life on earth. In this context, palladium catalysed cross-couplings have emerged as exceptionally powerful and useful methods for C-C bond formation. However, the reaction is largely limited to C(sp2)–C(sp2) bond formation. There are very few examples of cross couplings to form C(sp2)–C(sp3) or C(sp3)–C(sp3) bonds due to inherent problems associated with transition metals. As such a fundamentally new approach is required to solve this problem. We plan to add aryllithium reagents to enantioenriched, secondary boronic esters and form intermediate boron-ate complexes. Subsequent one-electron oxidation of the aromatic ring would result in dearomatization leading to a radical cation which would trigger a 1,2-migration/rearomatization sequence. Exciting preliminary results involving sp2-sp2 bond formation shows that this novel concept is viable (using DDQ as oxidant) and we will study its development and in particular its application in the crucial C(sp2)–C(sp3) bond formation. We will explore organic and inorganic multi-electron oxidants as well as the use of emerging redox photocatalysis. The latter method has the potential to provide an especially green solution to the problem. Even more exciting is the prospect of retaining the boron moiety after oxidation and 1,2-migration as this will allow the rapid construction of highly complex molecules. Once again preliminary results show that the concept is viable and will represent another significant step in organic chemistry. This methodology will be applied to the synthesis of challenging molecules.

Keywords: boron chemistry,cross-coupling,c141 organic chemistry,c111 method development in chemistry,c112 catalysis,c118 photochemistry
Role of Pc-G and Trx-G genes in the cellular memory of extrinsic signals in plants (PLANT-MEMORY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-05-07
Duration (months): 24.0
Total project cost (EUR): 168794.4
EU funding (EUR): 168794.4
Participants: 1
Project status: CLOSED

The life of plants differs fundamentally from animals in two key aspects; they are (i) sessile and (ii) missing a nervous system. Nevertheless, plants monitor changes in their environment and are able to memorise and anticipate these changes. The molecular basics underlying plant memory are not well understood. Epigenetic modifications of chromatin are obvious candidates to provide a memory at cellular level, as they can maintain stable patterns of gene expression in response to transient environmental signals. The project will focus on histone modifications and will clarify their global influence on the memory of stress in plants. Response to environmental stress became the subject of choice for the study of the plant memory for two main reasons: (i) No other event has a larger impact on the whole plant and causes more changes in the transcriptome, implying a similar high influence on the epigenetic machinery. (ii) Due to the emerging importance of stress adaptation in plants, the anticipated results will also be highly relevant beyond basic research. The researcher is a highly trained scientist with many years of experience in the fields of epigenetic and developmental biology of plants. The project was developed to a large extent independently by the researcher, resulting from own experience in epigenetic research and study of recent scientific literature. Understanding stress memory of plants has significant direct and indirect implications for applied sciences. As it becomes more and more clear that global warming causes huge damage in the agriculture of Europe, research in this area is likely to lead to new stress adaption strategies and so, in a long-term perspective, to better crop yields, and increased food quality and safety. The project will also contribute directly and indirectly to several objectives of the European Research Area such as Life Sciences, Genomics and Biotechnology for Health, Food Quality and Safety, and Sustainable Development.

Keywords: polycomb-group,trithorax-group,pc-g,trx-g,epigenetic,extrinsic signals,cellular memory,stress memory,stress response,chip,rip,chromatin-associated ncrnas,arabidopsis thaliana,plant
Identifying the Location and Extent of Populations Trapped by Environmental Change in the Mekong Delta: An Agent-Based Modelling Approach (TRAPPED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-10-01
End date: 2016-09-30
Duration (months): 36.0
Total project cost (EUR): 291852.6
EU funding (EUR): 291852.6
Participants: 1
Project status: CLOSED

The UK Foresight Migration and Global Environmental Change Project recently concluded that migration is likely to be increasingly influenced by environmental change in the future through the impact of climate change on economic, social and political drivers. However, the range and complexity of the interactions between these drivers means that it will rarely be possible to distinguish individuals for whom environmental factors are the sole driver. In parallel, within debates about climate change adaptation there has been an emerging trend to position migration as an adaptation strategy to environmental shocks and stresses. However, migration is expensive, requiring a number of assets/capitals. This can result in some populations who experience the impacts of environmental change seeing a reduction in the very capital required to enable a move. Environmental change is therefore equally likely to make migration less possible as more probable. In the decades ahead, millions of people are thus likely to be unable to move away from locations in which they are extremely vulnerable to environmental change. To the international community, this ‘trapped’ population is likely to represent just as important a policy concern as those who do migrate. In determining the extent and location of these populations the non-ubiquity of migration within a community needs to be accounted for in order to separate those people who want to migrate but are unable to do so from those who are unwilling to migrate and instead choose to cope with livelihood stresses in alternative ways. This distinction requires a contextually driven analysis of the decision to migrate or stay. Such a focus on the migration decision is suited to an agent-based modelling approach which takes into account an individual’s intention to migrate, the influence of migration and non-migration behaviour of others and their perceived ability to migrate within a decision mediated by household and community-level factors.

Keywords: v105 human and social geography,v201 climatology and climate change,v107 population dynamics,s106 globalization - migration,s113 communication networks,agent-based modelling