Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microbial Interactions: Nitrifiers and their Partners in Complex Wastewater Microbiome (INTERACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 214344.72
EU funding (EUR): 214344.72
Participants: 1
Project status: SIGNED

Microbial interactions shape the structure, function, and resilience of microbiomes in wastewater treatment plants (WWTPs), directly impacting performance. Nitrifiers, as chemolithoautotrophs and primary producers, are particularly suitable for studying these interactions by assessing carbon flow through metabolite tracing with stable isotopes. This project aims to uncover the principles governing microbial interactions between nitrifiers and their partners through three work packages: identifying interaction partners, inferring their interactions by genome analysis, and verifying these interactions in situ. Potential partners will be identified combining co-occurrence network analyses, fluorescence-activated cell sorting of activated sludge microflocs containing nitrifiers, and amplicon sequencing to identify co-sorted microbes. Fluorescence in situ hybridization (FISH) will be used to confirm their spatial co-localization with nitrifiers. Next, deep long-read metagenomics will generate metagenome-assembled genomes (MAGs) of nitrifiers and their potential partners for genome analysis and metabolic modeling, identifying possible types of interactions. The hypothesized interactions will be verified using FISH and stable isotope probing (SIP) combined with chemical imaging such as mid-infrared photothermal (MIP) imaging and matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) to identify exchanged metabolites in situ. This project is among the first to integrate SIP, FISH, and chemical imaging (MIP and MALDI-MSI) to study microbe-microbe interactions directly in complex microbiomes at the single-cell or cell cluster level. The findings will provide new insights into interaction mechanisms within complex microbiome and help design strategies to promote stable nitrifying communities in WWTPs. The developed workflow will also be highly valuable for studying microbial interactions in other environmental and medical microbiomes.

Keywords: nitrification microbial interactions microbial ecology chemical imaging wastewater treatment
Coherent Spintronic Networks for Neuromorphic Computing (CoSpiN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 1499072.5
EU funding (EUR): 1499072.5
Participants: 1
Project status: SIGNED

Neuromorphic computing uses networks of artificial neurons highly interconnected by artificial synapses to perform vast data processing tasks with unmatched efficiency, as needed, for instance, for pattern recognition or autonomous driving tasks. The synaptic connections play a paramount role to create better hardware realizations of these networks. However, it is very complex to realize large interconnectivity by electronic circuitry. COSPIN overcomes this connectivity constraint by using the eigen-excitations of the magnetic system - the spin waves - to connect state-of-the-art artificial neurons based on spintronic auto-oscillators. COSPIN’S main goal is to create and experimentally validate innovative physical building blocks for a novel nano-scaled, all-spintronic network structure which incorporates all necessary properties for neuromorphic computing including high nonlinearity, interconnectivity and reprogrammability. By design, COSPIN works at the boundary between oscillator-based computing and wave-based computing. It uses interference, frequency-multiplexing, and time-modulation techniques as well as spin-wave amplification to significantly increase the connectivity between neurons. Reprogramming of the network is implemented by a direct physical link to magnetic memory solutions as well as by reconfiguring spin-wave circuits. By using coherent wave interference and nonlinear wave interaction, COSPIN paves the way for novel coupling phenomena for complex artificial neural networks far beyond the state-of-the-art of current hardware realizations. Using cutting-edge micromagnetic simulations enhanced by inverse design methods, the artificial networks will be designed and tested prior to their nano-fabrication. Experimental investigations will be mainly carried out using micro-focus Brillouin light scattering. This allows for local investigation of the individual neurons and synapses, and significantly simplifies the interpretation of the network dynamics.

Keywords: magnonics,neuromorphic computing,oscillator and wave based computing
Programmable Atomic Large-scale Quantum Simulation 2 - SGA1 (PASQuanS2.1)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Research and Innovation actions
Countries involved: Germany,Austria,France,Italy,Spain,Slovenia,Finland,Croatia
Call: HORIZON-CL4-QUANTUM-02-SGA - Developing large scale quantum simulation platform technologies (SGA) (HORIZON-CL4-2022-QUANTUM-02-SGA, 2022)
Start date: 2023-04-01
End date: 2026-09-30
Duration (months): 42.0
Total project cost (EUR): 16594068.75
EU funding (EUR): 16594068.75
Participants: 31
Project status: SIGNED

The project Programmable Atomic Large-scale Quantum Simulation (PASQuanS2.1) is the first decisive step toward the transformation of the European landscape for programmable quantum simulators, finally delivering internationally leading platforms involving over 1000 neutral atoms in optical tweezer arrays and also in optical lattices. In the context of this Specific Grant Agreement, we will bring together partners from academia and industry (including technology enablers, platform developers, and end-users) to address central technological challenges. We will connect technologies across national borders and use our combined expertise and technologies to scale up the system size, reduce noise and temperature, and improve stability. We will test and transfer know-how between trapped ion and neutral atom platforms and integrate the hardware with application-specific software stacks for analogue solutions of relevant real-world problems, including verification and optimal control techniques. We will facilitate the expansion and networking of the supply chain and startup companies delivering platforms, en-route to the delivery of technology readiness level (TRL) 6-7 quantum simulators, including both cloud-based platforms, and quantum simulators linked with existing high-performance computing infrastructure. We will work with the end-user community across academia and industry to identify new specific applications where quantum simulators provide a practical quantum advantage over traditional high-performance computing. We will particularly address potential applications in materials science, quantum chemistry and in optimisation. We deliver a clear plan for dissemination, exploitation, and communication. This includes developing and protecting intellectual property, and to expand awareness of quantum simulators and their capability and applications amongst policy makers, industry, and the general public.

Keywords: analogue quantum simulation,optical lattices,neutral atoms,tweezer arrays,rydberg atoms,trapped ions,quantum annealing,variational quantum eigensolver,practical quantum advantage
A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis (MONALISA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Belgium,Austria,Greece,France,Netherlands,Czechia,Italy,United Kingdom,Germany,Spain,Ireland
Call: Pragmatic clinical trials on minimally invasive diagnostics (HORIZON-MISS-2023-CANCER-01, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 7232386.25
EU funding (EUR): 7232386.25
Participants: 26
Project status: SIGNED

High-risk neuroblastoma accounts for 15% of cancer related-deaths in children. Half of the >1500 patients yearly diagnosed with neuroblastoma in the EU have high-risk disease, which will relapse or progress in half these cases after first-line treatment. Relapsed neuroblastoma is aggressive and often therapy-resistant. Monitoring for disease relapse and therapy response is crucial for the survival chance of these patients. The current standard-of-care for monitoring are imaging technologies and bone marrow assessment, which are costly, invasive and a burden for children, who often require anesthesia. These drawbacks limit how often is monitored. More sensitive, less invasive and less toxic monitoring techniques are needed. The mutational spectrum often changes in recurring tumors, which may explain therapy resistance and provide additional druggable targets. Imaging, however, provides no information about molecular characteristics. Liquid biopsy tests are minimally invasive, allow frequent sampling and sensitively detect tumor molecular markers in tumor-derived DNA and messenger RNA circulating in peripheral blood. MONALISA aims to close existing gaps and establish liquid biopsies as standard-of-care to monitor relapsed/refractory neuroblastoma, as a blueprint for other pediatric cancers. Reliable, early assessment of molecular progression or relapse is the main aim of the pragmatic randomized clinical trial proposed in MONALISA. We develop a digital decision support tool to help oncologists use the new monitoring and apply patient-reported outcomes to integrate patient viewpoints and assess the effect of minimally invasive, liquid biopsy diagnostics on quality of life. We will establish whether events can be detected earlier using liquid biopsy monitoring, and whether better overall survival is enabled by earlier diagnosis and treatment interventions. This essential step towards personalized medicine will support reliable disease monitoring under treatment. “This action is part of the Cancer Mission cluster of projects on ‘‘Diagnostics and Treatment (diagnostics).”

Keywords: minimally invasive diagnostics,liquid biopsy,quality of life,clinical decision support,pragmatic clinical trial,patient reported outcome,peadiatric cancer,neuroblastoma,clinical decision support
CarBon nanotube exohedral and endohedral functionalization for integration in neaR-Infrared organic liGHT emitting devices (C-BRIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 3
Project status: SIGNED

Single-walled carbon nanotubes (SWCNTs) possess uniquely diverse optoelectronic properties that depend critically on their exact diameter and chiral structure. Their quasi one-dimensional structure, high carrier mobility, photochemical and mechanical stability, combined with extremely narrow and tunable emission in the near-infrared (NIR), make them interesting candidates as active material in NIR organic light-emitting diodes (OLEDs) or light-emitting transistors (LETs). The integration of SWCNTs in OLEDs and LETs has so far been limited by their typically low intrinsic emission quantum efficiency. Enhancing the SWCNTs emission efficiency, therefore, requires an in-depth understanding of the complex exciton photophysics, in particular, that of the multiple dark excitons. In this project, we will investigate the filling of the SWCNTs inner hollow core combined with functionalizing their outer wall with particular triplet sensitizers. This provides two orthogonal degrees of freedom to enhance intersystem crossing to the triplet state and at the same time to make the triplet excitons bright, aiming for highly efficient SWCNTs triplet phosphorescence as a NIR emission source. To investigate the particular effect of the functionalization on the triplet exciton photophysics, we will make use of a unique technique that combines optical spectroscopy with the spin-selective magnetic resonance technique, namely optically-detected magnetic resonance (ODMR). Finally, as a proof-of-principle, these functionalized SWCNTs will be integrated in LETs and OLEDs. In operando characterization through, amongst others, electrically-detected magnetic resonance (EDMR) will be performed to determine the role of the spin-dependent electron-hole recombination processes in the devices, opening new avenues to highly emissive NIR-OLEDs/LETs, essential for a wide range of biomedical and biosensing applications.

Keywords: carbon nanotubes,organic light emitting devices,triplet excitons,magnetic resonance spectroscopy,optically detected magnetic resonance,electrically detected magnetic resonance
Every smell you take – Smell-induced conditioning of the immune system during infections (MemoSniff)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Croatia
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 1993125.0
EU funding (EUR): 1993125.0
Participants: 1
Project status: SIGNED

The nervous and immune systems are the body’s primary sensory interfaces, perceiving and responding to environmental stimuli. Both systems can recall past challenges, enabling them to mount responses that anticipate and adapt to ever-changing situation. Recent research indicates that the brain can recall past infections, forming a new axis between neurological memory and immune response. A notable example of such interaction is Pavlovian or classical conditioning, where organisms learn the timing and causal relationships between internal and external stimuli, enabling them to prepare responses before significant events even occur. Importantly, pioneering studies have shown that the immune system can also be conditioned. However, it is still unclear whether conditioning can be used to boost immune response upon pathogen reencounter or during revaccinations. Furthermore, the fundamental neuroimmune mechanisms that promote conditioning remain largely unexplored. Although Pavlov initially used a bell to condition dogs, other stimuli, e.g. smells, can be even more effective due to their strong connection to memory and emotion. For example, the scent of freshly baked cookies can evoke vivid childhood memories. So, could the application of smell during a viral infection or vaccination trigger a stronger secondary immune response? Therefore, we hypothesize that an olfactory stimulus received during a primary infection or vaccination enhances the immune response after subsequent encounters. Thus, we propose combining advanced immunological and neuroscience techniques to understand how multiorgan, neuro-immune circuits regulate the immune response after conditioning with odor. Furthermore, we will investigate whether activating these circuits can inhibit pathogen replication, considering the limitations of current antiviral drugs and raising antibiotic resistance, with the goal of revolutionizing infectious disease prevention and boosting the effectiveness of vaccinations.

Keywords: memory cd8 t cells,infections,neuro immune interaction,odors
The first utility-oriented, agnostic software platform for quantum-centric drug discovery (KvasirAccelerator)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 4497453.75
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Humanity is exploring the limits of computing to solve the world’s biggest challenges with unprecedented speed and precision. While quantum hardware is being matured into a commercial technology, there is still no quantum software capable of addressing real business problems. Furthermore, quantum computing will inevitably exacerbate the complexity of current computational workflows for non-coding experts to extract knowledge. At Kvantify, we are developing Kvaser, the first platform-agnostic, explainable, customer-centric quantum software tool, to be operated by the end-user. With EIC funding, we will develop advanced algorithms for quantum chemistry and machine learning that will solve real-life drug R&D problems beyond the scope of classical resources. Kvaser will empower R&D scientists to run molecular and biochemical simulations on modern hardware with unmatched speed and accuracy, enabling high precision quantum chemistry calculations for efficient and accelerated drug discovery.

Keywords: drug discovery,computer sciences,algorithms and complexity,quantum computing,big data,life sciences randd,pharmaceutical randd,machine learning,digital services
Impacts of Changing Climate on Arctic Shelf Hydrogeology (WarmArctic)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Malta,Germany
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-05-01
End date: 2025-10-31
Duration (months): 30.0
Total project cost (EUR): 177251.52
EU funding (EUR): 177251.52
Participants: 2
Project status: CLOSED

Rapidly thawing Arctic permafrost is an important, but poorly constrained, contributor to global carbon budgets and an unknown in the climate change equation. Arctic shelves are critical regions in terms of fluid dynamics due to high organic matter and groundwater fluxes, thin permafrost, and shallow gas hydrate stability zones. Predictive modelling of the Arctic subsurface is challenging due to highly transient multi-physics processes and data-acquisition constraints (related to harsh climate and remote terrains), which lead to critical data sparsity and high uncertainties. Using advanced computational methods, we aim to develop a systematic 'process-level' understanding of how climate-change related warming along Arctic shelves impacts permafrost integrity, ice-layer distribution, sub-permafrost groundwater, and gas and gas hydrate dynamics. We also aim to understand how these processes influence seafloor morphologies (e.g. pingos, pockmarks), which can provide useful proxies for linking (easier to access) seafloor observations with underlying (data-sparse) sub-seafloor processes. Our models and methods will be developed in a highly generalized framework which, within this project, will be specifically applied to study climate change impacts on the fjords of Svalbard in the high Arctic. Beneficiary of this funding will be University of Malta, where the applicant (a mathematician) will receive training in seafloor data acquisition, processing and interpretation, and practical aspects of continental shelf geomorphology and hydrogeology, which will empower her to make meaningful and judicial use of data in her modelling studies. The project goals align with UN Sustainable Development Goal on Climate Action, and our findings will have high scientific and socio-economic impacts by bridging key knowledge gaps and offering comprehensive predictive framework to government agencies, NGOs, and commercial entities for assessment of warming-related risks in the Arctics.

Keywords: arctic shelf hydrology permafrost degradation entrapped gas gas dynamics gas hydrate dynamics sediment fluid interaction seafloor morphology pingo and pockmark formation
HORIZON ACADEMY: CONNECTING AND TRAINING NCPS TOWARDS A UNIFIED SUPPORT SYSTEM (NCP4HE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Euratom
Destination: Euratom
Action type: Coordination and support actions
Countries involved: Spain,Greece,Czechia,Lithuania,Italy,Austria,Iceland,Cyprus,Denmark,Germany,Slovakia,Armenia,Belgium,Croatia,France,Hungary,Ireland,Latvia,Luxembourg,Moldova, Republic of,Norway,Poland,Portugal,Serbia,Sweden,Tunisia,Türkiye,United Kingdom,Finland,Georgia,Romania
Call: Horizon Europe National Contact Point (NCP) Horizontal Support (HORIZON-EURATOM-2022-NCP-IBA, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 4011812.25
EU funding (EUR): 3999999.75
Participants: 39
Project status: SIGNED

The NCP4HE project has been designed, on one hand, to bring together and support the needs of the NCP National Coordinators and Legal & Financial NCPs communities and, on the other, to boost a closer and more efficient coordination and cooperation among the different NCP configurations through the infrastructures inherited by the Bridge2HE project, namely the HE NCP Portal and the NCP Virtual Campus, which the project will continue maintaining and developing, enlarging them in content, functionalities and userbase. A large series of activities involving training events, e-learning courses, pre-meetings, meet and exchange workshops, coffee-talks, and mentoring activities, have been planned to provide horizontal support to the whole NPC community, improve mutual learning, and create a structured space for exchange, with a particular focus on newcomers. NCP4HE will also prepare the ground for NCPs in the transition from Horizon Europe to the next Framework Programme working closely with the European Commission and their agencies to ensure a proper interaction with NCPs during that preparatory process. NCP4HE brings together a wide and comprehensive consortium of 36 NCPs host organizations from 22 MS and 9 AS countries, spanning three continents. Additionally, 11 of the 15 widening member countries are represented in the consortium. The project includes a balance mix of NCPs from countries with extensive participation in Horizon 2020 with NCPs coming from countries with low level of participation. This wide spectrum of partners is there to ensure that the project activities and outputs serve as many NCPs as possible, but also that the whole community needs are taken into account when designing and implementing the planned actions.

Keywords: ncp,ncp networks,ncp portal,training,e learning,newcomers,landf ncp,ncp coordinators