Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of Prostaglandin D2 in cancer-associated inflammation. (PGD2CRI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-01
End date: 2011-08-31
Duration (months): 24.0
Total project cost (EUR): 164877.53
EU funding (EUR): 164877.53
Participants: 1
Project status: CLOSED

Cancer associated inflammation is well known to contribute to tumour progression,and pro-inflammatory mediators, including cytokines and prostaglandins, can drive malignancy. Prostaglandins are generated from arachidonic acid by the action of cyclooxygenase (COX), and include PGE2 as a major pro-inflammatory mediator, and PGD2 that has anti-inflammatory activity. While it is well known that PGE2 promotes tumourogenesis, there is little known about the role of PGD2 in cancer. Our aim is to establish the role of PGD2 in tumour progression in vivo using a syngeneic transplantable mouse model of ovarian cancer and a two-stage skin carcinogenesis model. We also aim to investigate the role of PGD2 in modulation of cancer-associated inflammation and tumour-associated macrophage (TAM) phenotype. We will use a mouse ovarian cancer model that recapitulates the peritoneal spread of stage IV human ovarian cancer. We will evaluate the role of PGD2 and its’ receptor, DP-1, using transgenic mice and synthetic agonists/antagonists. We will also use a two-stage skin carcinogenesis model to study the role of PGD2 in carcinogen-induced inflammation-associated cancer. There is a great deal on interest in the therapeutic use of COX inhibitors in cancer, we hypothesise that the potential benefits of COX inhibitors in inflammation-associated cancer may be hampered by inhibition of protective, anti-inflammatory PGD2. Our preliminary data suggest PGD2 is indeed protective in a mouse model of stage IV ovarian cancer. These further studies will not only establish a rationale for selective inhibition of prostaglandin synthesis rather than COX in ovarian cancer but may also suggest DP-1 receptor agonists could offer a new therapeutic avenue in inflammation-associated cancer.

Keywords: pgd2,dp-1,cancer,inflammation.
Sounds of War: Music in America during World War II (AMERICA, MUSIC & WAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-01
End date: 2010-08-31
Duration (months): 12.0
Total project cost (EUR): 68143.58
EU funding (EUR): 68143.58
Participants: 1
Project status: CLOSED

Musicians in America were deeply involved in all aspects of World War II, from military service to radio propaganda, whether in the Office of War Information or in the State Department. They included such well-known composers as Samuel Barber, Marc Blitzstein, Aaron Copland, and Roy Harris. Compositions such as Copland's "Fanfare for the Common Man"; (1942) and his ballet "Appalachian Spring"; (1944) were as much related to war-time concerns as Blitzstein's "Airborne Symphony" (1943-46) or Morton Gould's "American Salute" (1943). Yet little is known about these musical activities during the war, nor how music related to the broader political and institutional contexts of this time. My project is the first one devoted to the musical and cultural study of art-music in the United States during World War II. The main outcome of the project is a book, "Sounds of War: Music in America during World War II" offering historical and cultural interpretations of musical life in the United States between 1939 and 1946. The book will address the following topics: 1. American musicians in wartime, their various roles as teachers, administrators, or members in government committees, ranging from the military, through the OWI and USO, to the OSS. I will discuss the contributions not only of composers but of performers, scholars, and patrons. 2. The roles, contributions, and challenges of European musicians in exile in the United States and their often complicated interactions with Americans. 3. Musical performance and composition as sonic responses to war, from questions of genre and style (for example the symphony) to those of programmatic response (for example the composition of so-called “Americana”). 4. The use of music as a tool in propaganda and morale efforts, exploring from both an aesthetic and a political perspective the work by musicians such as Copland and Toscanini for the OWI, the State Department, the OSS, and other institutions.

Keywords: musicology,history of music,american studies,cultural studies,music and nationalism,music in exile
Nanoelectronics: Concepts, Theory and Modelling (NANOCTM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Netherlands,Germany,Switzerland,Spain,France,Hungary,Poland,Italy
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 2466208.21
EU funding (EUR): 2466208.21
Participants: 10
Project status: CLOSED

The NanoCTM network will tackle major challenges in the theory of nanoelectronics. Ten internationally-leading European theory-of-condensed-matter groups from nine different countries [including one of Europe’s leading industrial electronics-research groups (QinetiQ)] have joined forces as full participants, combining theoretical expertise in nanowires, quantum dots, carbon-based electronics, and spintronics, along with interaction and proximity effects in small dimensions. Our highly-integrated approach to nanoscale transport will represent a major step towards the realisation of future scalable nanotechnologies and processes. In the longer term, the insights gained will contribute to the fabrication of novel functional nanoscale architectures and their integration into a higher hierarchical level. System parameters such as electric field, light, temperature or chemical reactivity are envisaged as possible drivers of future nanoelectronic devices.

Keywords: theory,electron-based nano-devices,molecular electronics,nanoelectronics
Micro and Nano Technologies for a new highly competitive European industry (MNT-ERA.NET II)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Coordination and support actions
Partnership: MNT-ERA.NET II (ERA-NET)
Countries involved: Austria,Germany,Finland,Spain,Germany,Belgium,Romania,Poland,Slovenia,Türkiye,Switzerland,Slovakia,Sweden,Portugal,France,Spain,Cyprus,Hungary,Norway,France,Czechia
Call:  (FP7-ERANET-2008-RTD, 2008)
Start date: 2009-03-01
End date: 2011-12-31
Duration (months): 34.0
Total project cost (EUR): 1624494.82
EU funding (EUR): 1333000.0
Participants: 21
Project status: CLOSED

• MNT-ERA.NET II will improve the coordination between funding programmes, research organisations and industries and secure durable cooperation between key actors from national and regional funding systems. It will promote the convergence of MNT programmes, the streamlining of procedures, and the efficient use of resources, thereby reducing the fragmentation of European funding instruments. The value of programmes for end-users will increase due to a close interaction with European industry, exploiting strategy papers and roadmaps (such as the MINAM SRA). • MNT-ERA.NET II will aim at the best possible integration of regional and national strategies with European needs and visions by setting up a joint RTD programme, ensuring complementarities with other funding instruments. This will help to reduce cross-European programme duplication and to overcome barriers to entry, enabling the rapid dissemination of research results and exploiting the scientific, technological and innovative impact of public investment in RTD. This will be of particular value for regions and countries that are catching up in terms of research investment and performance. Innovative joint calls, operated in a variable geometry approach, will be widely promoted among the target groups, especially high-tech SMEs. They will reflect the needs identified by the European R&amp;amp;D community, thus opening an attractive and efficient tool for transnational RTD. • MNT-ERA.NET II will therefore stimulate the increased and more rapid uptake of new micro- and nano-technologies within Member states industry. It will support the broad implementation of decisive knowledge for high added-value products, processes and applications and provide strategic and practical contributions to enhancing the competitiveness of the European industry. • MNT-ERA.NET II will prepare an ERA NET PLUS to achieve maximum impact of joint programming by mobilising substantial funding from member states and the EC.

Keywords: micro- and nano technologies coordination of funding programmes joint programme
Chromosomal addresses and mechanism of chromatin binding by the Scc2/Scc4 cohesin and condensin loading complex (CHROMOSOME STABILITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-01-01
End date: 2011-12-31
Duration (months): 24.0
Total project cost (EUR): 171867.63
EU funding (EUR): 171867.63
Participants: 1
Project status: CLOSED

In eukaryotic cells, cohesion between sister chromatids allows chromosomes to biorient on the metaphase plate and holds them together until they separate into daughter cells at anaphase onset. Accurate control of the mechanisms implicated in sister chromatids cohesion after DNA replication and chromosome condensation during mitosis are essential for faithful chromosome segregation during cell division. The aim of this project is to characterise the chromosomal features underlying Scc2/Scc4 binding to chromosomes and to understand the mechanism by which cohesin and condensin are loaded onto chromatin by the Scc2/Scc4 complex using as model organism Saccharomyces cerevisiae. The understanding of the mechanism of action of this complex is of particular interest since mutations in human Scc2 also result in sister chromatid cohesion defects, and are the cause of a severe developmental disorder, called Cornelia de Lange syndrome. The latter has been linked to Scc2 and cohesin’s role in transcriptional regulation, which the complexes also participate in. It is also worth to mention that chromosome segregation defects are commonly observed in cancer cells. Gaining insight into how the Scc2/Scc4 complex contributes to sister chromatid cohesion, chromosome condensation and even transcriptional regulation will advance our knowledge of fundamental aspects of chromosome biology and help in the understanding of human disease.

Keywords: molecular biology,molecular genetics,cell biology
Cross Layer Algorithms for Phealth (CLAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-05-15
End date: 2011-11-14
Duration (months): 30.0
Total project cost (EUR): 265301.57
EU funding (EUR): 265301.57
Participants: 1
Project status: CLOSED

One Laptop per Child (OLPC) is a technology research oriented educational project aiming to provide low cost information processing equipment to children around the world with new opportunities to explore, experiment and express themselves. The project was initiated by MIT Media Lab and has recently concluded the first cycle research work that resulted to the basic configuration laptop ready to be shipped. The healthcare domain is of special relevance for this project. A WSN of vital sign sensors (including electrocardiogram, blood pressure, etc.) and mobile wireless display devices (the OLPC in our case) can be employed to monitor patient health in an outpatient environment (e.g. home or care center).This research discipline is known as phealth. A number of medical wireless portable actuators (including respirators, infusion pumps, etc.) using the information of the vital sign sensors can be employed to care a patient in an emergency hospital set-up after a disaster. The OLPC project represents a new challenge for pHealth because by nature it creates electronic communities of educated users in technologically poor or even virgin environments. Health status on the other hand, together with education, represent the two major challenges for those parts of the developing world that have found (even partial) solutions on drinkable water and nutrition. An OLPC interconnected community has the means to support a prevention initiative aiming at facilitating disease management and health status control within a larger (to the community) population, by monitoring, processing and transmitting personal, ambient and environmental parameters. Today’s pHealth systems assume a technology advanced environment. Mitigating it to the OLPC reality should take into account power consumption, network bandwidth and processing limitations. On top of that the community oriented health monitoring is a novel concept, that, we introduce it here for the first time.

Keywords: phealth,wireless sensor networks,health telematics,digital divide
Predicting the Properties of Carbonaceous Pitches via Molecular Modeling (ADVCARBONMATLS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-03-01
End date: 2011-08-31
Duration (months): 12.0
Total project cost (EUR): 100110.32
EU funding (EUR): 100110.32
Participants: 1
Project status: CLOSED

The dramatic escalation in energy prices over the past year has brought a new sense of urgency to the development of strong but lightweight advanced materials for increased fuel efficiency. With one-fifth the weight of steel and equal or superior properties, advanced carbon materials are clearly a key solution to today’s energy problems. Because of their exceptional stiffness and ultra-high thermal conductivity (4 times that of copper), the potential market and value to society of inexpensive, pitch-based carbon fiber with a good balance of properties is enormous. Unfortunately, the current processes for converting pitches into graphitic structures are much more of an art than a science, with the molecular composition of the starting pitches, a broad mol wt distribution (MWD) of polycyclic aromatic hydrocarbons (PAHs), being largely unknown. We propose a collaborative effort between Clemson University (USA) and NTUA (Greece), with experimental work at Clemson University providing critical input into the development at NTUA of experimentally validated atomistic and mesoscale models for carbonaceous, pitch-derived oligomers. The objectives for the proposed work at NTUA are as follows: 1. Use Clemson’s unique dense-gas extraction (DGE) technique to isolate oligomeric fractions (i.e., monomer through tetramer) of narrow and well-defined MWD from raw carbonaceous pitches. 2. With the experimentally obtained molecular structures and number distributions from Clemson as input, use molecular dynamics (MD) and replica exchange MD (REMD) to predict the experimentally measured phase densities, softening points, and heat capacities for each oligomeric fraction of pitch. 3. Use the above atomistic MD work to guide the development of mesoscale models for carbonaceous oligomers. 4. Use mesoscale models to predict the relationship between the oligomeric composition of pitches and their thermodynamic and transport properties.

Keywords: chemical engineering,molecular modeling,computational chemistry,advanced carbon materials,petroleum pitch,coal tar pitch,carbonaceous oligomers
Adaptation of Pseudomonas aeruginosa to the human host during chronic infections (PACI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-07-01
End date: 2012-06-30
Duration (months): 36.0
Total project cost (EUR): 334410.2
EU funding (EUR): 334410.2
Participants: 1
Project status: CLOSED

Pseudomonas aeruginosa (PA) is an important bacterial pathogen causing a wide range of acute and chronic infections (CI). It usually expresses a yellow-green pigment. It is a major cause of respiratory CI in patients with underlying diseases such as cystic fibrosis (CF) leading to a progressive lung damage. Pathogenesis in CI implies a genetic diversification of PA, with emergence of atypical mutants such as brown pigment producing PA (bpPA). PACI study aims to explore the adaptation process of PA in CI, through the example of bpPA and to evaluate the clinical outcome of the emergence of such mutants. Ten clinical (CF and non-CF) or laboratory bpPA, and their isogenic yellow-green counterparts, have been identified. Preliminary data showed a large deletion in the same chromosomal region in bpPA when compared to their parental strains. Deleted genes are involved in chimiotactism, metabolism, resistance to antibiotics, synthesis of lipopolysaccharides, biofilm formation, anaerobic respiration and regulation. This strongly suggests that bpPA deeply modify their behaviour and virulence strategy in patients. The applicant will identify the deleted genes in bpPA using comparative genomic DNA hybridization microarrays and to assess variations in resistance to antibiotics and pyocins, growth under diverse conditions, metabolism, motility and virulence factor production. He will correlate the emergence of bpPA in CF-patients with disease progression using existing clinical data and bacterial collection. This proposal will permit the fellow, now in position of Associate Professor/Hospital Practitioner in the Dpt of Bacteriology, University of Franche-Comté (Besançon, France), to conduct the project during 2 years in the Dpt of Microbiology, University of Washington (Seattle, USA) before resuming his position in France. Characterization of these chronically-adapted clinical isolates will contribute to define new therapeutical options for the treatments of CI due to PA.

Keywords: chronic infections,microbiology,adaptation,genomic,virulence,cystic fibrosis,pseudomonas aeruginosa
Multi-scale Computational Tool for Self-Consistent Calculations of Thermodynamic and Electronic Properties of Nanosized Solutes (MUSTSOLVIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 229154.95
EU funding (EUR): 229154.95
Participants: 1
Project status: CLOSED

The ultimate goal of this proposal is to develop a multi-scale computational tool for selfconsistent calculations of the electronic structure of nanosized solutes and the density distribution of solvent molecules around them. The aim of the project is to combine the advantages of the reference-interaction-site-model-self-consistent-field (RISM-SCF) methodology with the power of multi-scale algorithms based on wavelets. The proposed development of the wavelet solver for the RISM-SCF equations should essentially contribute to the state-of-the-art of the integral equations theory for molecular liquids. Hierarchal algorithms used in the approach can convert the original concept into a powerful computational tool and will allow me to construct a robust computational scheme for the self-consistent-field calculations. These findings together with the novel method of extracting and parameterization of the data on the bridge functional will make realistic accurate calculations of various properties of nanosized solutes. The output of the project will be a library of programs available in a timely and user-friendly manner to all potential participants. The developed computational tool bridges the gap between quantum and statistical mechanics, providing a deep insight and understanding on detailed arrangements of the electron and the solvent distributions. When partnered with linear scaling algorithms for quantum calculations, the method will yield chemists an ability to design novel materials with an unprecedented degree of control.

Keywords: computational chemistry,integral equations theory,reference interaction site model,wavelets,multi-scale analysis,computational tool,self-consistent-field calculations,nanosized solute
ROBOTics for Development Of Cognition (ROBOT-DOC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Switzerland,Italy,Sweden,Germany,Germany,Sweden
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-09-15
End date: 2014-09-14
Duration (months): 60.0
Total project cost (EUR): 3492830.0
EU funding (EUR): 3492830.0
Participants: 9
Project status: CLOSED

The ROBOT-DOC proposal aims at the establishment of a multi-national doctoral training network for the interdisciplinary training on developmental cognitive robotics. Developmental robotics is a novel approach to the design of robots that takes direct inspiration from the developmental mechanisms studied in children by psychologists and cognitive neuroscientists. The Fellows will develop advanced expertise of domain-specific robotics research skills and of complementary transferable skills for careers in academia and industry. They will acquire hands-on experience through experiments with the open-source humanoid robot iCub, complemented by other existing robots available in the network’s laboratories. The hardware and software of iCub is just becoming available, so ROBOT-DOC provides an excellent one-off timely opportunity to make real international progress in Europe by training a critical mass of researchers. Research training will be centred on a series of training milestones such as two summer schools, international conferences and interdisciplinary research methods workshops. Fellows will also be directly involved and closely supervised for research in novel projects on embodied cognition, motivational and affective mechanisms, neuro-robotics modelling, developmental psychology, sensorimotor learning, social interaction and higher-order cognitive modelling. An individual coaching programme will support each Fellow’s training progress as well as professional and personal enhancement through individualised skill development plans. The ROBOT-DOC network consists of an excellent balance of academic and industrial partners, and of European and international laboratory leaders in developmental cognitive robotics. The network activities will have a significant impact on the career perspectives of the Fellows through training opportunities on industrial and academic research projects and skills. The network will contribute to the enhancement of the European R&amp;amp;D interd

Keywords: cognitive systems,cognitive robotics,developmental robotics,artificial intelligence,computer science