Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart Citizen Education for a greeN fuTure (GreenSCENT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Innovation actions
Countries involved: Spain,Italy,Austria,Germany,Spain,Cyprus,Romania,Serbia,Finland,Greece,France,Denmark
Call: Enabling citizens to act on climate change, for sustainable development and environmental protection through education, citizen science, observation initiatives, and civic engagement (H2020-LC-GD-2020-3, 2020)
Start date: 2022-01-01
End date: 2024-12-31
Duration (months): 36.0
Total project cost (EUR): 6511232.5
EU funding (EUR): 5549458.75
Participants: 16
Project status: SIGNED

GreenSCENT aims at developing a competence framework embracing all the Green Deal focus areas through an iterative, participated, experience and learning-by-doing based design approach. GreenSCENT will develop the GreenComp framework using both experts and researchers inputs and advise, citizen participation and stakeholder engagement initiatives; then it will test the framework on the field, in different European regions, different educational levels (from primary schools to higher education), at different engagement levels (from observation to data collection and processing, to contribution to scientific and policy agenda). Pilots will implement a range of pedagogies (collaborative learning, debate, research-based learning, inquiry-based learning) and demonstrators, digital, physical and hybrid educational technologies designed for or integrated into the project from existing initiatives. GreenSCENT legacy will consist of the Competence Framework (GreenComp), its Methodolog, Use Cases, User Guides; Training kits codesigned for implementing the framework; SCENTbox, the set of digital, physical and hybrid demonstrators developed by the project; and ECCEL, a European "driving license" for Climate and Environmental competences and skills, that will be tested during the project. GreenSCENT activities will involve more than 100 experts including the External Advisor Board members, already supporting the project and coming from all European Regions; about 45 schools and universities across EU will implement the pilot, while the Open Innovation Challenges designed and implemented by Agorize will cover the entire European Union and impact on tens of thousands of citizens. A special attention will be devoted to promote and foster the adoption of the framework, through the several tools developed, involving stakeholders (educational institutions, policy and decision makers, HR and industries) in the exploitation strategy of the project.

Keywords: innovative pedagogies,citizen engagement,experiment based learning,science driven policy codesign
Empowered decision-making in simulation-based engineering: Advanced Model Reduction for real-time, inverse and optimization in industrial problems (AdMoRe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,France,France,France,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 2080164.96
EU funding (EUR): 2080164.96
Participants: 8
Project status: CLOSED

“AdMoRe: Empowered decision-making in simulation-based engineering: Advanced Model Reduction for real-time, inverse and optimization in industrial problems” aims at providing in-depth training of Early Stage Researches (ESRs) in the development and application of state-of-the-art computational models and numerical methods to solve cutting-edge engineering problems. The main driving factors of all the beneficiaries are reduced order modeling techniques for real-time, inverse and optimization problems. In fact, these issues are seen by industry as a major asset to increase performance and competitiveness. The ultimate goal is to produce the next generation of European research engineers, leaders in the use of these methodologies for industry related problems. To achieve the ETN objectives, AdMoRe is based on training-through-research of ESRs with personalized frontier-research projects and active participation in network activities (viz. industrial placements, AdMoRe schools, conferences, dissemination, organization of events). Training will involve multi-disciplinary modeling (i.e. solids, fluids, structures, electromagnetics, acoustics), inter-disciplinary modeling (i.e. fluid-structure interaction, electro-magneto-mechanics, thermo-mechanics, aerodynamic noise) and new emerging scientific fields (i.e. geometrically enhanced finite elements/volumes, reduced order techniques, validation…), with a highlighted industrial edge bringing necessary transversal skills (i.e. through active involvement of the industrial partners). Furthermore, ESRs will be trained to develop core entrepreneurial skills to successfully move ideas into commercial practice through a series of transversal-entrepreneurship modules, as part of their training. The active involvement of industrial partners in AdMoRe ensures that both the research development and the ESR training will deliver research engineers that will be able to lead computer modeling in European industry and enterprise.

Keywords: computational mechanics,reduced order modelling,simulation based engineering
Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine (MEL-PLEX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Germany,Ireland,Israel,Germany,Italy,Ireland,Belgium,Switzerland,Greece,France,United States,Luxembourg,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2014-12-01
End date: 2018-11-30
Duration (months): 48.0
Total project cost (EUR): 3583870.17
EU funding (EUR): 3583870.17
Participants: 20
Project status: CLOSED

Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines and the associated European training needs provide the foundation for the MEL-PLEX ETN. MEL-PLEX aims to understand the network-level and multi-scale regulation of disease-relevant signalling in melanoma through a combination of quantitative biomedical and computational research approaches that go significantly beyond the current state-of-the-art. Coordinated by the RCSI Centre for Systems Medicine, MEL-PLEX will train 15 early stage researchers through a highly interdisciplinary and intersectoral research training programme. MEL-PLEX comprises 11 beneficiaries and 7 partner organisations from 11 countries, including European and international leaders in personalised melanoma therapy, melanoma systems biology and cancer systems medicine. MEL-PLEX aims to (i) achieve an unmatched depth of molecular and mechanistic disease understanding, (ii) will exploit this knowledge to develop and validate predictive models for disease progression, prognosis and responsiveness to current and novel (co-)treatment options, and (iii) will provide superior and clinically relevant tools and biomarker signatures for personalising and optimising melanoma treatment. The MEL-PLEX ETN addresses current needs in academia and the private sector for researchers that have been trained in an environment that spans across biology, medicine and mathematics, that can navigate confidently between clinical, academic and private sector research environments, and that have developed an innovative and creative mindset to progress research findings towards applications.

Keywords: cancer,melanoma,systems biology,systems medicine,molecular medicine
Optimisation of an on-board adsorbent/catalyst unit for aviation fuel thermal stability improvement (FUEL DEOX)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom
Call: Catalytic control of fuel properties for large VHBR engines (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 344046.25
EU funding (EUR): 344046.25
Participants: 1
Project status: CLOSED

The research programme proposed by the University of Sheffield experimentally investigates the application of an optimized on-board adsorbent/catalyst unit to reduce the tendency of jet fuel that contains dissolved oxygen to produce solid carbonaceous deposit in the fuel system and injection system at moderate temperature regimes. Improved fuel thermal oxidative stability offers the fuel to serve as a better heat sink, absorbing more waste heat from VHBR engines and using the heat to benefit in the engine performance cycle. This leads to more efficiency in comparison to adding extra cooling systems employing bleed air that is dumped overboard, and could yield around 2% SFC improvement in association with heat exchanger weight and volume savings. Furthermore, the elimination of overboard bleed is a potential to reduce IR signature. To achieve the programme goal, the following project objectives are proposed: 1) Optimise the size of the adsorbents/catalysts unit in small scale, bespoke experimental device with respect to flow regime and bulk fuel temperature following a Design of Experiments approach 2) Simultaneous thermal oxidative stability assessment of deoxygenated fuel using low medium scale test device namely, “High Reynold Thermal Stability (HiReTS)” 3) Compositional analysis of deoxygenated fuels with particular focus on side reactions 4) Fuel lubricity assessment 5) Calculation of adsorbent longevity using available quantum chemistry methods 6) Calculation of trade-off between thermal stability enhancement and lubricity decrease using available quantum chemistry methods 7) Project scale up and use of the optimised adsorbent/catalyst unit in a TRL5 scale engine representative jet fuel system simulator, namely the “Aviation Fuel Thermal Stability Test Unit (AFTSTU)” 8) Recommend future development. The oxygen separation by adsorbent/catalysts shows more advantages in comparison to the other deoxygenation methods being developed for aviation fuel thermal stability enhancement.

Keywords: aviation fuel thermal stability,autoxidation,thermal degradation,fuel deoxygenation
Exploring the role of TFEB in exosome biology and in novel approaches for treatment of lysosomal diseases (REBuILD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Exosomes are small vesicles released to the extracellular environment by almost every cell type, with important functions in mediating intercellular communication in several physiological processes, including organism development, immune responses, neuronal communication and tissue repair. In addition, these vesicles have attracted much interest from the biomedical research community for their potential as biomarkers for diseases, therapeutic agents and vehicles for drug delivery. Despite this, little is known about the mechanism and molecular players involved in exosome biogenesis and secretion. The aim of this application is to expand our current knowledge on exosome biology and their therapeutic potential. Preliminary results suggest that Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis, lysosomal exocytosis and autophagy induction, also controls the expression of various exosome-associated genes. By using mouse and human cells upregulated or knocked-down for TFEB expression, the applicant will establish a role for TFEB in exosome biogenesis, cargo selectivity and secretion. Furthermore, the applicant will determine the role of other TFEB-related cellular pathways, including starvation and Ca2+-related pathways, in regulating exosome formation. Finally, the applicant will explore the therapeutic potential of exosomes in cellular and mouse models of lysosomal storage disorders (LSDs). Collectively, this application combines both basic research and translational approaches to expand our current understanding of exosome biology and to provide proof of principle for novel therapeutic approaches of rare diseases.

Keywords: lysosomal storage disorders,exosomes,tfeb
MULTI-CONCEPTUAL DESIGN OF FIRE BARRIER: A SYSTEMIC APPROACH (FireBar-Concept)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 2429987.5
EU funding (EUR): 2429987.5
Participants: 3
Project status: CLOSED

The development of science and technology provides the availability of sophisticated products but concurrently, increases the use of combustible materials, in particular organic materials. Those materials are easily flammable and must be flame retarded to make them safer. In case of fire, people must be protected by materials confining and stopping fire. It is one of the goals of the FireBar-Concept project to design materials and assembly of materials exhibiting low flammability, protecting substrates and limiting fire spread. The objective of FireBar-Concept is to make a fire barrier formed at the right time, at the right location and reacting accordingly against thermal constraint (fire scenario). This fire barrier can be developed in several ways according to the chemical nature of the material and/or of its formulation: - Heat barrier formed by inherently flame retarded materials (e.g. mineral fibers, ceramic …) and exhibiting low thermal conductivity (note the assembly of those materials can also provide low thermal conductivity controlling porosity and its distribution) - Evolution of reactive radicals poisoning the flame and forming a protective ‘umbrella’ avoiding the combustion of the material - Additives promoting charring of the materials and forming an expanding carbonaceous protective coating or barrier (intumescence) - Additives forming a physical barrier limiting mass transfer of the degradation products to the flame The FireBar-Concept project is multidisciplinary and it requires expertise in material science, chemical engineering, chemistry, thermal science and physics. The approach is to make 5 actions linked together by transverse developments (3) according to this scheme: (i) fundamentals of fire barrier, (ii) multi-material and combination of concepts, (iii) modeling and numerical simulation, (iv) design and development of experimental protocols and (v) optimization of the systems.

Keywords: reaction to fire,resistance to fire,flame retardancy
Interacting with Active Particles (InterActive)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Finland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1499938.0
EU funding (EUR): 1499938.0
Participants: 1
Project status: SIGNED

Active particles refer to out-of-equilibrium self-propulsive objects such as biological microswimmers and engineered colloidal particles that can form various fascinating collective states. Active particles are easy to observe experimentally but notoriously difficult to interact with due to their fast and stochastic dynamics at both single-particle and collective state levels. In this project, I aim at scientific breakthrough in both instrumentation that allows direct interaction with active particles and using the methodology to progress substantially our understanding of dynamics and phase transitions of active particles. The first part focuses on rendering active particles, including E. coli, C. reinhardtii and Quincke rollers, permanently magnetized and designing suitable hardware for controlling them in real time. These particles are rendered “intelligent” by programming their behavior based on real-time image analysis (long-range vision) and steering with external magnetic field. I will program these particles to reveal the limits of using local dissipative hydrodynamic near-fields to guiding active particles, and demonstrate unambiguously the extent to which a single active particle within a collective state can control the collective behaviour. The second part aims at realizing tuneable magnetic traps and other conservative potential energy landscapes for non-magnetic active particles by using magnetophoresis in superparamagnetic fluids. I will use the technique to establishing confinement-activity phase diagrams for both biological (C. reinhardtii) and synthetic (Quincke rollers) active particles in quadratic confinements. I will further reveal the role of dimensionality (1D vs 2D vs 3D) in the phase transitions of active particles and carry out the seminal investigation of active particles in periodic potentials. The results and methodologies will have a major impact, both immediately and in long-term, on experimental physics of active particles.

Keywords: active particles,self propelled particles,microalgae,bacteria,crowding,crowded environments,phase transitions,magnetic tweezers,magnetic confinement,magnetophoresis,magnetic traps
Fluorescence lifetime optical biopsy system (FORECAST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The ultimate goal of this Fellowship is to train a talented researcher through a research project focused on the development of novel tools for the in vivo real-time assessment of the respiratory chain activity (NADH/FAD ratio) and mitochondrial dysfunction in tissues. This will be achieved by means of both laser fluorescence spectra and lifetime fluorescence data analysis, supplemented with additional optical measurements (laser Doppler flowmetry, tissue reflectance spectroscopy) in order to correct the impact of affecting factors (changes in blood perfusion, blood volume, blood oxygenation). The Fellow – Dr. Evgeny Zherebtsov – will be trained in biomedical optics, a fast growing field of science and medical application.He will receive access to a unique training experience at the host – Aston Institute of Photonics Technologies (AIPT), Aston University (Prof. E. Rafailov), and at academic and industrial secondment partners: University College London (Prof. Andrey Abramov), University of Bari, Italy (Prof. Annamaria De Luca), Axxam S.p.A., Italy (Dr Jean-Francois Rolland). The FORECAST outputs will be relevant to the EU life sciences sector by offering new cost-efficient technologies for real-time in vivo screening studies of metabolic activity in application of testing of new chemicals for efficacy and safety in small animals and test tubes during drug discovery and epithelium cancer diagnostics. The products transformed from the FORECAST outputs will contribute to the enhancement of EU scientific excellence. The project brings together a talented young Fellow with a strong biomedical science and engineering background, and an internationally growing group of researchers at Aston University with expertise in the area of developing laser-based photonic devices for biomedical research and clinical diagnostics. The Fellow will be further supported by medical expert co-hosts who will help train the Fellow in key skills and support the translation process.

Keywords: optical biopsy,fluorescence lfetime spectroscopy,tissue reflectance spectroscopy,laser doppler flowmetry,mitochondrial dysfunction,cancer diagnostics in vivo,nadh,fad redox ratio
Metal powder coating system with nano-technology pre-treatment. (PreNANOCOAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

preNANOCOAT presents a new innovative metal powder coating system for metal tubes manufacturing industry. Metal tube´s coating is a major issue, since tube´s performance depends on its perfect coating. ANDERLINI MECCANICA SRL presents a new system for the coating of its tubes, with an innovative approach that includes a newly developed nano-technology pre-treatment, IR/UV curing and a specillay designed gripping device that, altogether with a compeltely automated process, ensures both the quality of the coatings as the best possible environmental techniques. Standard coating systems use dangerous substances such as phosphates and chromates, generating also important amounts of hazardous sludge that needs waste treatment process. Estándar curing ovens are big and demand enormous amounts of energy, as standard curing time of the tubes is never inferior to 20 minutes. Our new innovative system avoids the use of phosphates and chromates and generates no sludge at all. By the use of IR/UV curing mechanisms, necessary curing time is reduced to just 3 minutes, with the consequent save in enery resources. Finally, with our specially designed gripping deviced, soon to be patented, and our completeley automated conveyor, we will ensure proper health and safety conditions for our workers, which is not always taking into account in most powder coating facilities.

Keywords: metal manufacturing industry metal tubes new powder coatiing system nano technlogoy pre treatment,uv curing,absence of hazardous waste products,reduction in energy consomption