Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Foundation Model-Based Biomarker Platform for Radiology and Clinical Trials (FoundRa)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: Human Centric Generative AI made in Europe (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 3571250.0
EU funding (EUR): 2499875.0
Participants: 1
Project status: SIGNED

The FoundRa project is based on 2 challenges: (1) Due to aging and population growth, there is an increase in pathologies that require radiology, from diagnosis to follow-up. (2) The ambition to make personalized medicine the standard of the future requires all kinds of biomarkers. Raidium is an agile, young and ambitious French company, born from the mission of the co-founders to accelerate the application of precision medicine and relieve radiologists from their enormous workload. Raidium delivers the first scalable interactive AI platform for radiology, supporting radiologists in their work, enabling a broader group of clinicians to benefit from radiology insights, and making clinical trials faster and more cost-effective. The innovation is a multimodal foundation model (FM) that uses self-supervised learning based on unlabeled data, creating scalable biomarkers; unlike current offerings where biomarker-generating AI can only target one segment, due to the time- and cost-consuming effort of supervised learning based on manually labeled data. The human-centric platform offers an intelligent interactive and intuitive human-machine interface that can be trained by the radiologist, leveraging their experience while performing automatic segmentation, annotation and analytical tasks, providing reports and decision support. Radium's beachhead market is to be an AI-enabled contract research organization for pharmaceutical companies, providing strategic AI-generated biomarkers. Radium's ultimate market is to provide an AI radiology platform as a Software as a Service (SaaS) to radiologists and clinical researchers in hospitals and pharma. With the support from EIC, we will train our FM, integrate it into our platform, and accelerate the creation of AI-based biomarkers. This initiative aims to revolutionize and bring about significant advances in the fields of precision medicine in respect to medical practice and clinical trials.

Keywords: multimodal foundation model precision medicine human machine interface self supervised learning few shot learning zero shot learning human centric ai clinical trials nash liver diseases oncology
Born Digital's DIGITAL HUMAN platform revolutionizes how cognitive functions are performed in both the back-office and front-line operations of public institutions and commercial enterprises. (Digital Human)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Czechia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 1950000.0
EU funding (EUR): 1950000.0
Participants: 1
Project status: SIGNED

The Challenge: Companies and public institutions are increasingly struggling with a shortage of qualified labor and the pressing need to optimize operational costs. This issue has intensified over the past years, driven by two primary factors: demographic changes and the high qualifications required for modern job roles. This problem is particularly acute within the European Union, where several member states are experiencing historically low unemployment rates. The resultant labor shortages are stifling economic growth and creating a critical challenge for both the private and public sectors. The Solution Born Digital's DIGITAL HUMAN platform revolutionizes how cognitive functions are performed in both the back-office and front-line operations of public institutions and commercial enterprises. This platform mimics human cognitive abilities, such as understanding documents, extracting crucial information, executing processes, engaging in logical reasoning, and creating documents. It communicates in various forms and features visuals that are virtually indistinguishable from those of a real human. Unique Selling Propositions (USP): - Rapid Iteration and Customization: The DIGITAL HUMAN platform allows rapid customisation digital human appearances, personalities, and capabilities to meet specific needs. This flexibility means modifications can be implemented within hours, far outpacing traditional methods that may take weeks or months. - Comprehensive Interaction Platform: By integrating visual generation with advanced conversational AI, large multimodal models, and analytics, the platform offers a holistic solution. This approach goes beyond mere visual representation, providing a seamless, interactive experience. Key Focus on reliability and transparency: - Reliability: zero hallucination level by fine-tuning of large/small multimodal models - Traceability: enhancement of our current debug/trace mode - Security: Implementing advanced cybersecurity measures

Keywords: digital human,cognitive operations,automation,government services digitisation
Powering Tomorrow with the Next-Gen Thorium Molten Salt Reactors to Burn Nuclear Waste (Th-MSR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The global energy demand is set to surge by 62-185% by 2050, driven by population growth and economic expansion. Despite being responsible for a staggering 75% of global greenhouse gas emissions, fossil fuels are projected to dominate the energy mix until 2050. Our generation faces a crucial challenge to find large-scale alternatives to fossil fuels that are affordable, safe and sustainable. Nuclear energy is instrumental in achieving these ambitions. It is a low-carbon energy source, emitting the lowest amount of CO2/kWh considering total life-cycle emissions of all energy sources. Copenhagen Atomics (CA) is developing breakthrough nuclear technology to enable a paradigm shift for green energy. We are pioneering a thorium molten salt reactor (Th-MSR), the Waste Burner, – a groundbreaking solution that burns nuclear waste to generate abundant and cost-effective energy. This next-generation reactor is engineered for faster construction, lower deployment costs, and reduced environmental impact compared to traditional reactors. The Waste Burner fits inside a custom-built 40-foot shipping container and can be mass-manufactured on assembly lines with an expected output of 1 reactor per day (per assembly line) once scale-up has been achieved. Additionally, the waste left behind by the CA reactor only needs to be stored for 300 years above ground, vs. 100,000 years of expensive deep geological storage. Our unique value proposition is industry-leading LCoE €20 per MWh in the mass production stage, lowest all-in CO2 emissions, mass manufacturing feasibility, waste reduction, and walk-away safety. This positions us as potentially the most affordable green electricity source in the 2030s. The Waste Burner presents a disruptive and sustainable alternative to fossil fuel-based energy, contributing to the decarbonization of energy systems, reducing Europe's dependence on fossil fuels, and providing affordable, secure and sustainable energy for Europe.

Keywords: advanced nuclear small modular reactor nuclear physics autonomous operation
AI-based Data Platform for Fair Social Policies (Politus)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Türkiye
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-12-01
End date: 2024-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The Politus Project will assess the commercial viability of proprietary natural language processing and machine learning technology for AI-based data-driven fair social policymaking. The project will verify the innovation potential of computational social science and policy-related novel methods from the PI’s ERC-funded Emerging Welfare Project (https://emw.ku.edu.tr). To deliver the technical and commercial proof of concept, the PI will establish the Politus Analytics Company, which will offer an AI-based data platform and fair data-driven policymaking consultancy services to two main client personas - political parties and municipalities. The Politus Project will address two interconnected problems of opposition political parties and municipalities in Turkey and other emerging markets regarding social policy making: (1) populist governments gain political advantage by abusing public social policies with the aid of big data, which disables opposition parties and municipalities to develop competitive electoral strategies (2) These big data sources are not available to non-governmental stakeholders, including opposition parties and municipalities, indicating a government-led information gap which opposition parties and municipalities cannot fill with traditional survey polling methods. The Politus project will develop an AI-based innovation that combines quantitative and computational methods in order to create a data platform that delivers representative, valid, instant, real-time, multi-country and multi-language panel data on key political and social trends, which will be used to design fair social policies for opposition parties and municipalities. Politus will serve its clients (municipalities and political parties) (i) the data and tools to pinpoint exact discretionary and clientelistic allocation of social policies (ii) data and insight to understand the needs and wants of the citizens and gain electoral advantage and (iii) the design of fair social policies.
Single-Chip Integration of MEMS Micropumps with Optical Waveguides for Laser Absorption Spectroscopy (VacLAS-Chip)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Norway,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 284179.68
EU funding (EUR): 284179.68
Participants: 2
Project status: SIGNED

Microbiological research is concerned with studies of microbial gas consumption and production, which is tightly linked to natural greenhouse gas emissions, but also sinks. Currently, such studies require large and expensive instrumentation like gas chromatography systems, which also sacrifice the sample during each measurement. This affects the conditions of the sample, and yields unsatisfactory temporal resolution due to the need for sample handling. In this project, I propose to leverage the latest advances in MEMS and nanophotonics to develop the first chip platform integrating optical waveguides with micropumps, which will facilitate tuneable diode laser absorption spectroscopy (TDLAS) under vacuum and in closed valume without sacrificing the sample gas. With the addition of lasers and light detectors, it will enable inexpensive, low weight, portable devices for real-time, in situ trace gas detection. Such device will not only impact microbiological research, but also sensor networks much needed e.g., in cities for controlling the air quality.

Keywords: micro electro mechanical systems,gas microfluidics,laser absorption spectroscopy,tdlas,gas spectroscopy,low pressure gas spectroscopy,mems pumps,micropumps,microfluidics,nanophotonics
Moral Agency in Election Campaigns (ELECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499998.75
EU funding (EUR): 1499998.75
Participants: 1
Project status: SIGNED

ELECT falls within the methodological framework of “grounded normative theory”. It combines normative democratic theory with a mixed-methods and comparative research design to investigate the moral agency of key stakeholders involved in contemporary election campaigns: candidates, campaign professionals, political journalists and citizens. The moral agency of electoral stakeholders becomes a subject of concern when they are confronted with normatively charged situations involving motivations to behave in ways that undermine democratic norms or political trust. The context in which electoral stakeholders exercise their moral agency has been changing, presenting them with new normative challenges relating to their respective electoral conduct. Recent changes include the strategic and communicative possibilities provided by big data and new media and the evolving competitive landscape relating to the emergence of new electoral challengers. Existing research on the tensions between contemporary election campaigns and democracy and political trust has primarily taken campaign outputs as its objects of study. Far less studied are the moral dimensions of the inputs concerning the role that the attitudes, beliefs and motivations of stakeholders play in influencing their conduct and how their moral decision-making is affected by institutions and regulations. Neglect of this input perspective leaves major knowledge gaps that limits our ability to accurately diagnose normative problems with campaigning and prescribe effective solutions. ELECT will attempt to fill these gaps by exploring the moral agency of electoral stakeholders in four countries that have been subject to recent disruptions in the campaign context, namely Germany, Italy, the UK and the US. Empirical data will be gathered using surveys, elite interviews and citizen focus groups. Diagnostic and prescriptive analyses based on this data will employ state of the art methods in normative democratic theory.

Keywords: democratic theory grounded normative theory moral agency election campaigns
High-performance adsorbents based on robust bijels stabilized by cellulose nanocrystals for direct air capture of CO2 (HANDLECO2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-15
End date: 2025-06-14
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

Direct air capture (DAC) has established itself as a promising technology to lower the atmospheric CO2 concentration permanently, thus contributing to climate change mitigation. Considering the billion tons of CO2 that need to be captured, high-performance chemisorbents from the most abundant natural polymer, i.e., cellulose, are of great significance for the practical application of such negative emission technology. The main objective of HANDLECO2 is to construct high-performance cellulosic DAC chemisorbents based on robust bijels, which is an emerging class of soft solid materials with interconnected hierarchical pore networks and semi-permeable interfacial layers. Cellulose nanocrystals (CNCs) with surface-immobilized 10-undecenoyl groups will be synthesized and then modified by clickable poly(ionic liquid)s (PILs) via simple thiol-ene click chemistry. The surface chemistry of PILs-modified CNCs will further be tuned by simple counterion exchange method. Next, the applicant will fabricate bijels of high stability by new methods to crosslink the CNCs with designed surface chemistry at the fluid-fluid interface. The robust bijels stabilized by CNCs will then be processed into aerobijels via simple freezing-drying. The numerous accessible amine groups on CNCs in combination with the bicontinuous porous structure and semipermeable interfacial layers of the final aerobijels will allow for high CO2 adsorption capacity and fast CO2 adsorption kinetics. The conceptualization of HANDLECO2 is based on the two-way transfer of knowledge between the host and researcher, and research objectives will be achieved through this knowledge transfer. This fellowship will offer an invaluable opportunity to reach the applicant’s career goal of leading his own independent research group in Europe academia. Moreover, the success of HANDLECO2 will undoubtedly lead to multiple positive impacts that will strengthen European excellence and competitiveness.

Keywords: direct air capture,chemisorbents,cellulose nanocrystals,co2 adsorption,poly ionic liquids
Targeting skin glycosylation patterns to protect threatened salamanders from disease driven extinction (GLOSSI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2479125.0
EU funding (EUR): 2479125.0
Participants: 1
Project status: SIGNED

Disease driven amphibian declines are frequently compared to the extinction of dinosaurs and have become an icon of the global biodiversity crisis. The deadly skin disease chytridiomycosis is causing the greatest recorded loss of biodiversity attributable to a disease. The recently introduced chytrid fungus Batrachochytrium salamandrivorans (Bsal) is expanding its range in Europe, remains unmitigated and thus poses an imminent threat to western Palearctic urodele (= salamanders and newts) diversity. While hypersusceptible species invariably die after exposure, other species show a much more variable, individual and dose dependent response, ranging from self-limiting infections with self-cure to lethal disease. My group recently discovered that host susceptibility correlates with the skin glycosylation pattern of salamanders, with cutaneous galactose content predicting variation in intensity of Bsal colonization. The variability of the skin glycosylation pattern offers a unique opportunity for marker directed selection of disease resistant salamanders. The overarching hypothesis of GLOSSI (Glycosylation in Salamander Skin Infection) is that variability of hereditary glycosylation patterns in the salamander skin underpins differential Bsal colonization and allows the selection of colonization resistant host lineages. To study the contribution of skin glycosylation patterns towards the development of salamander resistance against the Bsal epidemic, GLOSSI will combine laboratory and field trials to study 1) the temporal dynamics and heritability of glycosylation patterns and associated susceptibility to Bsal infection in urodeles, 2) the potential of natural selection towards increased resistance in infected, natural urodele populations and its impact on population dynamics, 3) the host genetics that underpin the epidermal glycosylation pattern and implications for disease resistance. GLOSSI will lead to novel strategies for curbing disease driven loss of biodiversity.

Keywords: wildlife diseases,chytridiomycosis,mitigation,skin colonisation
Defining Clinical and Molecular Phenotypes of Multi-Drug Resistance in difficult to treat Rheumatoid Arthritis (MDR-RA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Italy,United Kingdom,Denmark,Netherlands,Norway,Sweden,Austria,Spain,Switzerland,Belgium,Germany,Portugal
Call: Tackling high-burden for patients, under-researched medical conditions (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7719665.5
EU funding (EUR): 7430426.5
Participants: 26
Project status: SIGNED

Rheumatoid Arthritis (RA) is the most common, chronic, inflammatory joint disease with a prevalence of about 1% of the adult population (22M patients worldwide and 7M in EU) and estimated to be responsible for 10,000 disability adjusted life years (DALY's) costing EU society €55B annually. Despite aggressive therapy, about a third of patients have to give up work within 5 years of disease onset mainly due to lack of response to multiple disease modifying anti-rheumatic drugs (DMARDs), multi-drug resistance (MDR). Thus, the main objective of this proposal is to define the clinical and molecular phenotypes leading to MDR in RA patients to prevent when possible or, when not possible, optimise the management of these patients. MDR-RA is highly relevant to the program, as these patients are often disabled, unable to work and paying a high personal and societal burden. Moreover, MDR-RA is under-researched and the underlying pathobiological mechanisms for resistance remain unknown, while as we have no predictors of therapeutic response to any of currently available drugs, inevitably treatment is based on trial-and-error. MDR-RA has the ambition of transforming care for these patients and deliver significant advances beyond the state-of-the-art methodologies, as for the first time, molecular pathology will be integrated into clinical, psychosocial, pain perception and imaging profiling in existing clinical cohorts to develop truly holistic predictive models for future clinical use (iCare-RA). The transformative potential of iCare-RA will be tested in a prospective randomised trial in comparison with routine standard of care, while its future implementation potential will be assessed through an early economic modelling. Finally, a strong management and dissemination strategy will facilitate further advancing science in the field, beyond the duration of the project, and future adoption by patients, specialist professional bodies, policy makers and regulatory authorities.

Keywords: rheumatoid arthritis multi drug resistance biologic therapies multi omic profiling health economic evaluation