Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hydrodynamics and entropy production in low-dimensional quantum systems (HEPIQ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-03-01
End date: 2027-02-28
Duration (months): 60.0
Total project cost (EUR): 1497850.0
EU funding (EUR): 1497850.0
Participants: 1
Project status: SIGNED

In the past years, quantum non-equilibrium emerged as a new principal research arena, promising to assist the current development of new quantum technologies and to shine a new light on disparate fields of theoretical and experimental physics, from black holes to condensed matter and statistical physics. As quantum dynamics represents a major challenge for modern computational methods, relevant developments have come from devising new generalised and extended forms of classical hydrodynamic theory to effectively describe its macroscopic features. This effort is nowadays constituting an essential part of contemporary theoretical physics, contributing to a deeper understanding of dynamical phenomena and providing new directions in different experimental areas. This proposal focuses on the interplay between classical non-linear dynamics and quantum evolution, promising to a) unveil a new deep comprehension of how the non-equilibrium dynamics in many-body quantum systems can dissipate or either recover quantum information and how effective non-linear classical behaviour emerges, b) release new efficient theoretical tools to access quantum many-body quantum systems which are strongly interacting and in non-equilibrium settings beyond linear response, far away from known regimes of low-energy, low-temperatures or weak interactions. The outcomes will provide new reliable and much needed theoretical methods as well as a new dictionary to catalogue and relate different non-equilibrium phenomena in quantum and classical physics and deepen our understanding of out-of-equilibrium matter.

Keywords: non equilibrium quantum many body,integrable models,tensor networks,non equilibrium statistical mechanics,luttinger liquids,one dimensional systems
Stratification of Patients using advanced Integrative modeling of Data Routinely acquired for diagnosing Rheumatic complaints (SPIDeRR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Netherlands,Sweden,Spain,Greece,United Kingdom,Hungary,Germany
Call: Computational models for new patient stratification strategies (HORIZON-HLTH-2022-TOOL-12-two-stage, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 5183000.0
EU funding (EUR): 5183000.0
Participants: 24
Project status: SIGNED

Globally 1.Globally 1.71 billion people have musculoskeletal symptoms, the leading contributor to disability. Early disease stratification is important to ensure appropriate care (most suited healthcare provider and best treatment choice). Currently the patient journey to diagnosis and effective treatment is long and inefficient, resulting in persistent disease burden and economical loss. This is due to insufficiently understood relations disease causes and similarities in symptoms between diseases, insufficiently distinguishing tests, trial and error approach in initial treatment. SPIDeRR aims to disentangle the real-life complexity of early diagnosis of rheumatic diseases by considering the complete web of factors influencing patients’ symptoms. SPIDeRR’s approach will go well beyond the state-of-the-art in the following ways: - By identifying different disease groups, requiring different therapies, amongst patients with similar symptoms in contrast to the traditional approach aiming to only capture one disease early. - By integrating all relevant data dimensions from every healthcare level (primary and secondary care and patients seeking advice online). - By translating and applying machine learning techniques from the “omics” field to clinical patient data, which will result in new pipelines for translational data science SPIDERR will deliver three clinical models -a symptom checker for patients -a decision support tool for (primary) care providers providing guiding additional examination and referral decisions -a patient-patient similarity network to optimise diagnostic groups in rheumatology and support treatment decision To achieve this we additionally deliver solutions for data integration and shared analyses though GDPR compliant digital research environment and federated learning pipelines. Finally we will test the acceptability of the models through stakeholders studies and provide an implementation scene tailored to current healthcare in Europe.

Keywords: musculoskeletal complaints,early diagnostics,rheumatic diseases,autoimmunity,disease prevention
Monitoring & Understanding bioSWITCH in-gel processes (bioSWITCHing Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Sweden,Hungary
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 493250.0
EU funding (EUR): 493250.0
Participants: 2
Project status: SIGNED

The ongoing bioSWITCH project has set forth a research program aiming to develop a radically novel approach to address current challenges in the therapy of hard-to-treat tumors (e.g., pancreatic cancer). The envisioned technology consists of an implantable bioorthogonal iontronic switch allowing spatiotemporally controlled release of highly potent drugs with electronic precision, reducing the need of systemic treatment of patients with limited efficiency. The technology relies on the innovative use of an iontronic pump, a bioorthogonal reaction and a hydrogel loaded with the bioorthogonally activatable chemotherapeutics (chemogel). With the combination of these next-level scientific and technological breakthroughs, it is possible to provide personalized, temporally controlled chemical delivery of drugs to the disease site with electronic precision via chemical wave function generation. Preliminary data suggest that the implementation of this transformative technology strongly relies on the basic understanding of the kinetics of the bioorthogonal reaction and subsequent drug liberation and diffusion in/from the gel. Fundamental understanding of basic events within the chemogel leading ultimately to drug release is indispensable toward reaching the long-term vision of the project. To gain these vital information, fast 3D imaging methods that produce optical signal variation related to such in-gel events is necessary. The widening partner proposes the development of a ground-breaking approach: a chemogel involving switchable fluorescent probes and bioorthogonal elements to serve as an optically imageable model of bioSWITCH. Their internationally recognized expertise in the field of bioorthogonally switchable optical systems ensures that they effectively address this highly complex challenge, which ultimately results in a deeper understanding of the fundamental events affecting chemical wave function generation facilitating the successful implementation of bioSWITCH.

Keywords: bioorthogonal chemistry,bioelectronics,drug delivery,fluorescent probes,fluorescence imaging,photochemistry
The shadow of migrants’ social networks: Towards a new theory of how social networks can increase migrants’ economic vulnerability (SHADOW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1499436.0
EU funding (EUR): 1499436.0
Participants: 1
Project status: SIGNED

SHADOW develops a new sociological theoretical framework, studying how social networks impact migrants’ economic vulnerability by creating social welfare deficits. In sociology, social networks have been assumed to improve migrants’ economic position by providing financial, informational, and instrumental support. Yet, evidence from other disciplines shows that they can also be harmful by serving as gatekeepers to labour markets or by providing misinformation. SHADOW addresses this gap in sociological understanding. SHADOW integrates theories from sociology, social psychology, and political science, introducing a novel multi-level, multi-group theory about why and how social networks can increase migrants’ economic vulnerability. First, it will use administrative data to identify and map the networks linked to migrants’ economic vulnerability. Second, it will examine how social networks increase vulnerability, testing a new theory of social welfare deficits - liabilities and constraints imposed by social networks- like pressure, misinformation, or stigma. Third, it will study migrants’ reactions to these social welfare deficits, such as distancing from harmful networks. Last, it will look at how welfare states impact these deficits and migrants’ economic vulnerability. SHADOW will compare four migrant groups residing in Europe with vastly different migration backgrounds and network structures. SHADOW will use a mixed-method approach, including administrative, survey, qualitative, and experimental data. It will advance the field of migration studies and generate a breakthrough in the sociological approach to social capital by including its negative impacts. SHADOW will also help policy-makers and stakeholders to design better policy interventions targeted at improving migrants’ economic position in Europe.

Keywords: social networks,migrants,economic vulnerability,welfare state
Synthesizing functionalized self-sensing geopolymer concrete in enhancing electromagnetic shielding efficiency and thermal stability (GEOSENSOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

The exponential growth of electromagnetic radiation pollution from electronic devices raises a lot of concern, resulting in biological threats. This adversely affects sectors, such as aviation, military, and medical industries. Thus, synthesizing smart, functionalized, and sustainable building materials with substantial shielding efficiency and thermal properties is needed to obtain safety and security demands. The self-sensing capability of geopolymer concrete is obtained from the piezoelectric effect, and can be enhanced by adding functional fillers, such as graphene oxide. Its reduced synthesis usually entails harsh chemicals and when improperly disposed, it creates a detrimental impact in the environment. Using an eco-friendly reducing agent, such as glutathione, and cross-linking with carbonyl iron aims to produce a high piezoelectric effect with high conductivity networks. While the surface functionalization improves both shielding efficiency and thermal stability when polydopamine is incorporated. The MSCA GEOSENSOR Postdoctoral Fellowship aims to demonstrate proof-of-concept by providing guidelines in geopolymer mix design construction and various assessments to check the sensing abilities, surface functionalization, shielding efficiency, and thermal stability of geopolymer products. It is a novel technique by utilizing green materials to further improve the aforementioned geopolymer properties. It also envisions a sustainable implementation anchored in MSCA Green Deal, resulting in lower energy usage, overall production costs, and environmental impact. Through scale-up production, the project's contribution to the circular economy and its economic feasibility can be evaluated. This project also addresses challenges stated by the UN SDG, such as building resilient infrastructure, promoting inclusive and sustainable industrialization, and fostering innovation (SDG 9).

Keywords: geopolymer,agro industrial wastes,self sensing,surface functionalization,circular economy
Reconstructing Paleolithic Population Dynamics Using Microstratified Paleogenomic Analysis (MicroStratDNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1460604.0
EU funding (EUR): 1460604.0
Participants: 1
Project status: SIGNED

Modern humans are defined and sustained by interactions and networks. In Paleolithic contexts, reconstructing interactions and networks is limited to inferences based on material culture or direct evidence of biological relatedness, but evidence on the latter in the form of human fossils is very rare. Still, archaeogenetic research can formulate supra-regional models for broad time periods based on only a few genomes by distinguishing ancient clades, but not to the level of interactions between human groups of particular cultural complexes. Recently, archaeological sediments and speleothems - karstic cave formations - have been revealed as a further genomic archive for past environments and past human populations initiating a new phase in archaeogenetic research. These new archives have the potential to greatly expand the archaeogenetic record as they stem from ubiquitous environmental sources and they do provide the spatial and temporal resolution to zoom into population dynamics at the group level. However, what this ancient DNA (aDNA) originates from and under what conditions it preserves over time are still open questions. I here suggest placing this paleogenomic data into a microstratigraphic framework, where individual depositional events are recorded in microscopic features, to overcome these problems and to provide high-resolution time series of population interactions. Using an interdisciplinary tool kit, I will (I) reconstruct the source, origin, and deposition of sedimentary and speleothem aDNA in archaeological contexts, (II) identify ideal preservation contexts for this type of aDNA with a focus on in-field assessments and (III) extract genomic time series from archaeological sediments and speleothems. I will apply this approach to Upper Paleolithic sites in Georgia to reconstruct the relatedness of the people using individual sites over time and across contemporaneous sites set against regional expressions of climate and paleoenvironment change.

Keywords: paleolithic,ancient dna,geoarchaeology,speleothems,microstratigraphy
Deciphering cellular and molecular mechanisms of β-cell regeneration (BetaRegeneration)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 2446645.0
EU funding (EUR): 2446645.0
Participants: 1
Project status: SIGNED

Glucagon-like peptide 1 (GLP-1) therapy was shown to regenerate β-cells in mice, but this did not translate to human. Early or intensive insulin therapy maintains residual β-cell function, but also causes weight gain and hypoglycaemia. Thus, currently no drug treatment can safely stop the progression of diabetes, a disease characterized by loss or dysfunction of insulin-producing β-cells. In breakthrough discoveries we identified the insulin inhibitory receptor (inceptor) as a druggable target for β-cell insulin sensitization and protection without the side-effects of insulin. Moreover, we combined GLP-1-mediated safe β-cell delivery of estrogen together with 60% reduced insulin therapy to restore β-cell function for diabetes remission. The overarching goal of BetaRegeneration is to explore new avenues of targeted and combinatorial β-cell protection and regeneration therapy. In Aim 1 we will reveal whether inceptor, beside desensitizing the insulin receptor, has also a function as insulin receptor in starvation/stress-induced insulin degradation and as scavenger receptor for insulin lysosomal degradation. This will reveal if inceptor can be targeted to enhance β-cell insulin sensitization, secretion and function. In Aim 2 we will translate our basic findings to in vivo animal and human model systems to explore GLP-1-mediated β-cell delivery and targeting of WNT and β-cell insulin/IGF1 signaling to enhance specificity and target several pathways at once. Furthermore, we will genetically and pharmacologically target inceptor and test if monoclonal antibodies alone or as drug conjugates can promote β-cell protection and regeneration. Our approach will reveal if combinatorial targeting of survival and regenerative pathways can stop β-cell loss and dysfunction. Taken together, the identification of clinically relevant targets and ways of combinatorial β-cell protection and regeneration therapy could open new avenues to stop and revert diabetes progression.

Keywords: diabetes,cell regeneration,human,insulin igf1 signaling,wnt,glp 1 receptor,inceptor,antibodies,ipsc,targeting
Atomic force microscopy-based exploration of layered double hydroxide nanoparticles adjuvant mechanism (AFM-LDH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-01-31
Duration (months): 29.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Layered double hydroxides nanoparticles (LDH NPs) composed by divalent/trivalent metal ions are efficient vaccine adjuvants to assist antigens to induce potent humoral and cellular immunity. However, the adjuvant mechanisms of LDH NPs still remains elusive. Since the metal ion species and ratio are closely related to the adjuvant activity of LDH NPs, this study will investigate how the metal ion composition will affect the adjuvant activity of LDH NPs. Then, an atomic force microscopy (AFM)-based approach to physico-mechanically map the specific interaction occurring between NP and Toll-like receptor-4 or scavenger receptor A1 in vitro on living cells. Finally, the adjuvant signaling pathways of LDH NPs will be investigated in antigen presenting cells. This study will greatly advance the knowledge on the interplay among nanomaterials and innate immunity. The single-cell, quantitative approach can be readily applied to study the binding of other nanomaterials and the testing of anti-inflammatory molecules on living cells of the innate immune system.

Keywords: layered double hydroxide atomic force microscopy
EXCELLENCE IN HUMAN-CENTERED LOGISTICS 4.0 (X-HuLog4.0)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Economic Sciences
Countries involved: Lithuania,Norway,Germany
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 1346362.69
EU funding (EUR): 1346362.69
Participants: 4
Project status: SIGNED

X-HuLog4.0 addresses the scope of the WIDERA 2023-ACCESS 02-01: TWINNING under the priority “spreading excellence and widening participation”. The project establishes cooperation with internationally leading research institutions – NTNU, TUDa and USAAR – and allows defining strategies for building capabilities and establishing networks that help Vilnius Gediminas Technical University to advance their R&I capabilities in human-centered logistics systems of the future (X-HuLog4.0). The objective of the project entitled X-HuLog4.0 – Excellence in human-centered logistics 4.0 is to fully realize and further develop the existing scientific potential of the widening partners VILNIUS TECH aiming at scientific excellence in human-centered logistics systems of the future. While the focus is on the widening partners, the project also enables the other partners to deepen their knowledge in this field and to contribute to the advancement and adoption of X-HuLog4.0 results across Europe. To this purpose, X-HuLog4.0 intends to: - increase the research and educational capabilities in Human-centered Logistics at VILNIUS TECH at the supporting partners; - establish a long-term knowledge transfer between the contributing parties with a special focus on young-stage researchers; - encourage the connection among researchers of the partner universities and other leading research institutes and promote networking; - enable VILNIUS TECH to act as knowledge centres providing modern methodologies, logistic tools and solutions in the area of human-centered logistics to transfer knowledge to the widening and associated countries; - increase the industry and society awareness on human-centered logistics and the value of a close collaboration with academia; - foster scientific developments through increases in the number of publications, patents, participation in research programs, and new products or services development.

Keywords: human centered logistics 4 0