Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Welded braids on 3D dynamics (WEB3)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 217076.16
EU funding (EUR): 217076.16
Participants: 1
Project status: SIGNED

The connection between braid group theory and topological dynamics arises from the remarkable applications of braid group theory to the study of the periodic orbit structure of iterated surface homeomorphisms. It began the early 1980s and has since grown into a significant area within the theory of low-dimensional dynamical systems. Braid theory, a very powerful and important tool, has been used extensively, among others, by Boyland, Ghrist, Guaschi, Hall, Matsuoka and Vandervorst for proving that the existence of certain orbits forces the existence of several other orbits and for showing how the orbits are interacting among them. A central objective of topological dynamics on 3-dimensional manifolds is to comprehend the structure of the orbits of a self-map. While there has been done a lot of research on the complexity of orbit structures in 3-dimensional dynamics, there are not known results that are analogous to the impressive known results about the orbit structure on surfaces that use braid theory. One of the main reasons is that the classical braid group theory is trivial on 3-dimensional manifolds. To counter this obstacle, WEB3 proposes to use the theory of welded braid groups, which is the three-dimensional analogue of classical braids. The aim of WEB3 is to extend the existing literature concerning the orbit structure of 3-dimensional dynamics and in particular to establish a new machinery for exploring the behavior of periodic points of homeomorphisms of 3-dimensional manifolds. This proposal will have significant and wide impact in the field of low-dimensional topology and topological dynamics by fostering innovation and creating new knowledge. WEB3 is the most fitting project for enriching the current literature both on braid group theory and on topological dynamics, since it combines knowledge from both of these two fields of mathematics and features the necessary tools for emerging them successfully together.

Keywords: low dimensional topology braid group theory welded braid groups topological dynamical systems
Exploring perineural invasion (PNI) mechanisms in Pancreatic Cancer using hyperpolarized 13C NMR (PCPNIHyp)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with 5-year survival rate of less than 7%. Existing treatments are limited because 90-100% of patients develop perineural invasion (PNI). PNI is associated with severe pain, poor prognosis, poor survival, and tumor recurrence, and involves nerve invasion by cancer cells, as a result of dynamic interactions between them and other cells in the tumor microenvironment (TME). Schwann cells (SCs) are part of this TME and are activated by cancer cells to become PNI promoters. To date, the question of how metabolic dysregulation generated by cancer cells, characterized by different levels of lactate and an acidic TME drives SCs-mediated-PNI remains unanswered. Taking account that PNI is still poorly understood and that there are no PNI-targeted diagnosis methods or effective therapies, this project pursues the study of the role of metabolic alterations induced by PDAC cells on SCs, and how that drives SCs activation and PNI. To achieve this goal, nuclear magnetic resonance (NMR) mediated hyperpolarization of metabolites as contrast agents that could be used later in clinical diagnosis without adverse effects will be used. Hyperpolarization by Para-Hydrogen-Induced-Polarization (PHIP) boosts the detectable NMR and magnetic resonance image (MRI) metabolites signals by a factor of >10000, it allows obtaining precise kinetic data on metabolites’ inter-conversion on short timescales, and the insights from cells can be directly translated into in vivo studies. All of this represents an advantage over standard biological studies, which often struggle to capture these types of events. Using NMR-PHIP technology with cellular and molecular biology-based techniques on SCs-PDAC cells co-cultures and on an in vivo PNI model, this project will contribute to identifying new predictive biomarkers for future monitoring and early diagnosis of PNI, as well as to the potential development of PNI-targeted therapies.

Keywords: pancreatic cancer,schwann cells,metabolism,nmr,para hydrogen induced polarization
Robust Econometrics of Games in IO (REGIO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1477651.0
EU funding (EUR): 1477651.0
Participants: 1
Project status: SIGNED

REGIO develops advanced econometric methods to identify and estimate economic fundamentals in games played by firms, addressing a broad spectrum of real-world industrial organization scenarios. These methods bridge critical gaps where existing techniques fall short and provide a disciplined framework to relax less credible assumptions about firm behavior and the game environment, enabling researchers to draw robust empirical conclusions. Their effectiveness is demonstrated through applications, supporting strategies to ensure fair competition, consumer protection, and a clearer understanding of distributional impacts and inequality. To achieve these goals, REGIO is structured around four pillars. Pillars 1 through 3 focus on designing identification and inference methods that remain robust to misspecification by imposing minimal restrictions on firm behavior and the game environment. By crafting new tools based on partial identification, these pillars tackle theoretical challenges, such as addressing multiple equilibria and firms’ potentially limited awareness of their competitive landscapes, as well as statistical challenges. Pillar 4 pioneers the use of the novel methods to real-world scenarios, demonstrating their practical applicability and bolstering informed market interventions. Through these pillars, REGIO not only advances econometric research but also significantly enhances the interface between economics and policymaking, improving our understanding of dynamics in modern markets.

Keywords: partial identification,inference,moment inequalities,repeated games,multiple equilibria
Career development of international talents of the energy research fields in the Iberian Peninsula (Talent4Iberia)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Finland,Chile,Sweden,Spain,Switzerland,Germany,United Arab Emirates,Norway,Italy,Estonia,Portugal,Slovenia,Australia,Belgium
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-01-01
End date: 2029-06-30
Duration (months): 66.0
Total project cost (EUR): 1432800.0
EU funding (EUR): 1432800.0
Participants: 23
Project status: SIGNED

Talent4Iberia Programme aims to promote research excellence in the Iberian Peninsula, with primary focus on the Extremadura Ecosystem of Science, Technology and Innovation (SECTI), by offering 10 interdisciplinary and inter-sectoral fellowships with a duration of 36 months for the mobility and training of postdoctoral researchers of any nationality to develop R&D activities in the field of energy storage in Extremadura, within the Spanish-Portuguese and international cooperation framework, with the purpose to promote the development of their professional careers in an exceptional research environment. Talent4Iberia will be promoted and coordinated by the Council of Economy, Science and Digital Agenda of the Autonomous Community of Extremadura, Spain, the unit with competences in research policies and programmes in the region. The programme will be implement by 3 Spanish recruiting institutions: the Foundation FUNDECYT Science and Technology Park of Extremadura - Iberian Centre for Research in Energy Storage (Fundecyt-CIIAE), the University of Extremadura (UEX) and the Centre for Scientific and Technological Research of Extremadura (CICYTEX), and will count with the participation of 21 associated partners (13 universities, 4 research centres, and 4 companies dedicated to the energy sector, from 15 different countries: 8 EU Member States (Spain, Estonia, Finland, Germany, Italy, Portugal, Slovenia, Sweden), 1 HE Associated Country (Norway), and 4 Other Third Countries (Australia, Chile, Switzerland, United Arab Emirates). The project is aligned with one of the research lines selected as a priority in the participants' policies, ENERGY STORAGE. With an international and interdisciplinary conception, it will also contribute positively to the development of territories with a high potential for scientific and technological development in the field of energy, and will serve as a pilot in the implementation of the HRS4R of the participating entities.

Keywords: energy storage research career gender balance green energy hydrogen and power to x thermal storage
Context-dependent flexibility in innate behaviours and their underlying neural circuitry (FLEXIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1544651.0
EU funding (EUR): 1544651.0
Participants: 1
Project status: SIGNED

Avoiding danger and approaching food are essential and highly conserved behaviours. To ensure an animal’s survival, such innate reactions need to be fast and reliable. However, in an everchanging environment, not only reliability, but also flexibility is required. How brain circuits are organized to allow for context-specific, flexible behaviour remains an open fundamental question. Here I propose experiments that dissect how brain circuits mediate context-specific reactions to survival-critical cues including threat and prey. A unique combination of viral tools, high-throughput neural recording techniques, and quantification of behaviour in different rodent species, will reveal how neural circuits can encode changes in the animal’s context and adjust to different situations. The strengths of this proposal are twofold: First, this research will make use of the reliable framework of innate behaviours that do not require learning, and which can be elicited with simple visual stimuli to assess flexibility. Second, I will compare the impact of three different contexts on these behaviours and their underlying circuits: How does ambient light affect innate reactions? How do animals respond to threat at different times of the day? How have species that evolved in different ecological niches developed distinct avoidance behaviours? Comparing the impact of these internal and external, transient and permanent contexts on the same, well-defined circuits and behaviours will, first, reveal general principles of context-specific flexibility; second, dissect whether neural circuits that underly similar behaviours are conserved across species; and third, determine which parts of the brain are most likely to adjust when changes in the environment requires behavioural flexibility. Together, this work will reveal how flexible behaviours are created in the brain and may provide a framework to assess cause and treatment of lack of such flexibility, e.g. in anxiety disorders.

Keywords: visuo motor processing,behavioural flexibility,evolution,innate behaviour,circuit dissection
Integrated Spectroscopy for Protein Analysis Using Metasurfaces and Interband/Quantum Cascade Devices (PROTEMIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland,Austria,Germany,Spain,Switzerland
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 4441707.14
EU funding (EUR): 4080420.4
Participants: 10
Project status: SIGNED

Proteins are the fundamental building blocks of life and are complex biopolymers. The pharmaceutical industry and medicine have an unmet requirement for dynamic, insitu monitoring of structural changes of proteins. Proteins may incorrectly fold during the expression process, or denature in response to changes in temperature, pH amongst others. These deviations lead to loss of function, loss of therapeutic effectiveness, increased immunogenicity or reduced product shelf life. For example, growing amounts of human milk are donated to serve the needs of pre-term infants but there is a lack of quality control to monitor protein quality during pasteurisation and storage. Current analysis techniques require extracting samples from the reaction vessel, which risks contamination, or use indirect measurements of the protein structure. PROTEMIC is a Double Doctorate Training Network that brings together the disciplines of Physics, Analytical Chemistry and Biochemistry to determine the protein structure from the sample’s Mid Infrared absorption spectrum without the use of labels or reagents. PROTEMIC builds on the team’s experiences with the successful OPTAPHI joint doctoral network and embeds the Doctoral Candidates into multiple disciplines to gain skills that cannot be obtained from a single host, and master biochemistry and spectroscopy. The project builds and expands on breakthroughs recently made in the OPTAPHI project, for example new photonic integrated circuits and world first photothermal spectroscopy results. PROTEMIC embeds metasurface and photonic integrated circuits into the reaction vessel to provide insitu mid IR spectroscopy for the first time and map structural changes during dynamic reactions in realtime. These results will improve the efficiency of the production of protein based pharmaceuticals and through the use of metasurface microtitre plates, allow the scalable screening of proteins for the encapsulation of oral vaccines, accelerating drug discovery.

Keywords: metasurfaces,interband cascade lasers,protein encapsulation
Citizen Attitudes Towards National and International Problems (CATNIP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2491860.0
EU funding (EUR): 2491860.0
Participants: 1
Project status: SIGNED

Political scientists have collected rich data for understanding the preferences of citizens regarding which policies their governments ought to enact, as well as for investigating where these preferences do and do not exist, and how they arise. In contrast, we have poor data and methods for understanding which problems citizens think are most severe and which government policy should be urgently addressing. These questions of problems and priorities are difficult to investigate because they are challenging to formulate in terms of closed-ended survey questions that yield cross-nationally and inter-temporally comparable data. This project addresses this gap by using innovative techniques to measure citizens’ views about problem severity and priority. The proposed applications, in turn, will push forward our understanding of how citizens understand what politics and policy-making are trying to achieve, how they interact with media information sources and their representatives, all of which are core concerns of the study of political behaviour and public opinion. This research would enable a major step forward in our understanding of several political science questions. First, which people, in which countries, are relatively engaged with and prioritise global problems (e.g. international environmental, security, and economic issues) by comparison to more immediate local or national problems? Are views about political problems generally stable over time, at the level of individual citizens or at the level of populations? Second, to what extent do major media sources and/or political actors set the problem agenda for citizens, versus responding to citizens’ existing problem agenda? Third, what are the electoral implications of politicians and media emphasizing or de-emphasizing specific problems? When is articulating a problem, perhaps even in the absence of articulating a policy solution, an important component of gaining credibility with voters?
Noise in Fluids (NoisyFluid)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1785875.0
EU funding (EUR): 1785875.0
Participants: 1
Project status: SIGNED

Fluids, in complex regimes, show random features. The aim of this project is approaching several questions around the randomness of fluids by means of a theory that could be called “Stochastic Fluid Mechanics”. The distinctive feature of this theory, opposite to others that investigated the stochastic features of fluids, is that it is based on the usual continuum mechanics equations, in particular the Navier-Stokes and Euler equations, but suitably modified by the presence of random elements, like an additive or a transport type noise. Stochastic equations of fluid dynamics have been studied already for three decades and the number of foundational results is very large. However, two basic directions have been explored only partially: a) the origin and the form of noise in fluids b) the consequences of the presence of noise. This project will make progresses in these two directions, describing the noise near boundary due to vortex productions, including the question of intrinsic stochasticity at the boundary, the propagation of additive noise at small scales to a transport-stretching noise at large scales, the consequences of transport noise on eddy viscosity, enhanced dissipation, enhanced coalescence, and other applications in turbulence and Geophysics. The most ambitious core of the project is putting together these pieces in a picture that explains the mechanism of regularization by noise for the 3D Navier-Stokes equations. The additive noise at small scales is responsible for a transport-stretching noise at larger scales which could prevent blow-up of high intensity vortex structures. We have already proved recently that a noise, of transport type only, has this regularization effect, but stretching amplifies vorticity and new progresses are needed to cope with both processes. We aim to use the experimentally observed fact that small scale velocity should be approximately orthogonal to vorticity in high intensity regions.
A sporozoite-based platform for expression of Plasmodium vivax antigens (OptiViVax-HOP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Netherlands,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 48.0
Total project cost (EUR): 526196.25
EU funding (EUR): 526196.25
Participants: 2
Project status: SIGNED

The OptiViVax consortium aims to accelerate research towards the development of effective vaccine- and antibody-based strategies for protection against P. vivax malaria. The inclusion of the widening partner, Instituto de Medicina Molecular (iMM), in OptiViVax will add to the consortium’s current capabilities, contributing to and expanding the project’s goals. At the core of iMM’s contribution to OptiViVax is a novel platform consisting of rodent P. berghei parasites, engineered to express selected P. vivax antigens (PbVac-Pv). The distinctive features of this platform, including its amenability to genetic modification, its non-pathogenicity towards humans, and its capacity to express heterologous Plasmodium antigens in their native conformation, make it uniquely suitable for the pursuit of the project’s objectives. Specifically, we propose to employ several PbVac-Pv parasite lines already available at iMM as a tool (i) for human vaccination against P. vivax; (ii) for the discovery of human monoclonal antibodies that can effectively inhibit infection by P. vivax; and (iii) to investigate the combined use of whole-sporozoite vaccines and adjuvants towards the enhancement of protective antibody responses induced by immunization. iMM’s state-of-the-art facilities and resources not only ensure the capacity to carry out the proposed work, but will also be accessible to the other consortium members. Thus, iMM’s addition to OptiViVax will expand the partners’ access to specialized technologies and capabilities, including flow cytometry and rodent facilities, a long-standing expertise in pre-clinical immunization studies and assessment of immune responses, and multiple rodent parasite and host models of infection. The evident complementarity between the concepts, models and resources available within OptiViVax and those brought along by iMM creates ample opportunities for synergies between the consortium members and amplifies the range of expected project outputs.

Keywords: malaria,platform,monoclonal antibodies,parasite,genetics