Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sensors for LArge scale HydrodynaMic Imaging of ocean floor (LAkHsMI)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Estonia,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Acoustic and imaging technologies (H2020-BG-2014-2, 2014)
Start date: 2015-04-01
End date: 2019-09-30
Duration (months): 54.0
Total project cost (EUR): 3040221.25
EU funding (EUR): 3040221.25
Participants: 6
Project status: CLOSED

LAkHsMI will develop a new bio-inspired technology to make continuous and cost-effective measurements of the near-field, large-scale hydrodynamic situation, for environmental monitoring in cabled ocean observatories, marine renewable energy and port/harbor security. We will design, manufacture, and field test prototype smart sensor cables that measure differential pressure and temperature on the ocean floor and enable high resolution imaging of the surrounding volume in space and time, is simple, inexpensive and has very low power consumption The cables can be connecting with existing cabled ocean observatories. The technology is inspired by the biophysics of fish hydrodynamic sensing. The technology is scalable from meters to possibly hundreds of kilometers and allows a high sampling frequency. LAkHsMI will also develop innovative methods for hydrodynamic imaging. It produces several continuous on-line information products for interdisciplinary oceanography and seismic geophysics but also for other applications including tracking fish and fish schools or (sub)surface traffic in harbours. Software interfaces developed in the course of the project will be integrated with existing observatory systems (such as EUROGOOS). LAkHsMI will design and implement the sensor cables on small large scales. Tests will be conducted in a tank, a pool, an in ocean observatory.

Keywords: operational oceanography,benthic currents,optical fibre sensor,hydrodynamic imaging,flow detection,hydrodynamic event detection and classification,turbulence measurement,lateral line perception
Cellular basis of Artemisinin resistance in malaria parasites (MALART)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-12-01
End date: 2026-11-30
Duration (months): 60.0
Total project cost (EUR): 2388242.5
EU funding (EUR): 2388242.5
Participants: 1
Project status: SIGNED

Blood stages of the protozoan parasite Plasmodium falciparum are responsible for malaria, a disease that kills more than 400'000 people annually. During its development in red blood cells the parasite internalises a large part of the host cell cytosol (hemoglobin) in an endocytic process and digests it in its food vacuole. We recently identified a critical connection of this hemoglobin endocytosis with resistance of the parasite to the current frontline drug Artemisinin, revealing the mechanism of resistance. Artemisinin is activated by hemoglobin degradation products and we found that Artemisinin resistant parasite endocytose less. Using a toolbox of recently established approaches to carry out functional studies in malaria parasites, we identified an entire series of proteins involved in endocytosis that are involved in resistance to Artemisinin. This included Kelch13, the molecular marker of Artemisinin resistance in field samples. This provides us with a unique opportunity (i) to elucidate how these molecules orchestrate endocytosis, a prominent essential process in these parasites that so far is not understood on a molecular level, (ii) to specifically understand the role of Kelch13 in this process and in resistance, and (iii) to elucidate the reason for the fitness cost that is associated with Artemisinin resistance and the compensatory mechanisms the parasite uses to mitigate them. We expect this research program to not only elucidate so far elusive key aspects of the cell biology of this important parasite, but also to identify critical constraints of Artemisinin resistant parasites and possible ways to circumvent ART resistance.
Pilot line for paper based electrochemical test strips dedicated to quantitative biosensing in liquids (IMPETUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Austria,Austria,Austria,Germany,Germany,Germany,Austria,Germany,Austria,Belgium,United Kingdom,United Kingdom,United Kingdom
Call: Paper-based electronics (H2020-NMBP-PILOTS-2017, 2017)
Start date: 2018-01-01
End date: 2022-10-31
Duration (months): 58.0
Total project cost (EUR): 6396305.0
EU funding (EUR): 6396305.0
Participants: 20
Project status: CLOSED

IMPETUS will combine paper, printing and microchip technologies to realise a pilot line capable of manufacturing fully integrated paper-based electrochemical biosensors that directly transfer the measured data to the user’s smartphone. These biosensors will be designed as self-powered disposable test strips that combine the simplicity of lateral flow tests with quantitative readout, which is enabled by the implemented electrochemical detection method. As an application example, we will fulfil the consumer need for fast point-of-care discrimination between bacterial and viral infections. In particular, IMPETUS will combine screen-, flexo- and inkjet-printing in a seamless roll-to-roll pilot line compatible to high-throughput fabrication. Here, the paper is employed as substrate for the printed circuits and a microchip, but also as active component of the printed battery as well as of the biosensor. This we will achieve by developing new technologies for paper manufacturing, coating and surface modification, and the respective processing will work hand in hand with the ink development (cellulose-based inks for fabricating the printed battery as well as bio-inks for surface functionalization and reagent deposition). A highly integrated and energy-efficient silicon microchip will be developed that enables electrochemical data acquisition, storage and contactless NFC transmission, and the microchip will be mounted onto the paper substrate by an inline placement process. In summary, the IMPETUS pilot line will pave the way towards the real world application of paper-based quantitative electrochemical diagnostic test strips, thereby clearly advancing the current state-of-the-art, which up to now has mostly focussed on individual fabrication processes and device concepts. The IMPETUS pilot line is conceived in such a way that during the project, all printing and assembly processes will be implemented and validated.

Keywords: paper based analytical devices,point of care testing,electrochemical biosensors,printing technology,functional printing,lateral flow tests
DOCtoral training programme in Functional Advanced Materials (DOC-FAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 3453120.0
EU funding (EUR): 1726560.0
Participants: 4
Project status: CLOSED

DOC-FAM is a COFUND Doctoral Programme with a duration of 60 months presented by the Spanish National Research Council (CSIC) and coordinated through the Institute of Materials Science of Barcelona (ICMAB). The main aim of the programme is the training of 22 early-stage researchers during 36 months each as the next-generation of scientists in the exciting field of Functional Advanced Materials, while at the same time offering a complete training experience to the recruited fellows. This doctoral programme builds up on the recent award obtained by ICMAB as one of the 22 “Severo Ochoa Centres of Excellence”, an award given by the Spanish Government that recognizes institutions from all areas of knowledge that perform cutting-edge research at world standards. The award as “Severo Ochoa Centre of Excellence” to develop “Smart Functional Materials for Social Grand Challenges” (FUNMAT, 2016-2019) demonstrates the outstanding international scientific leadership of ICMAB in the field of Advanced Functional Materials and Nanomaterials. The aim of the research programme offered in DOC-FAM is to complement the training aspects of FUNMAT by offering the recruited fellows an excellence training programme in the bourgeoning field of Functional Advanced Materials through an interdisciplinary, intersectorial and international approach with the support of several partner organisations from the area, four of them contributing to the co-funding of the doctoral programme. The designed training programme combines different types of activities that will enhance their research and personal skills, providing them with new career perspectives.

Keywords: advanced functional materials,training,complementary skills,excellence
A compact radioisotope dating device for rapid sample analysis (CompactDating)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-10-01
End date: 2018-09-30
Duration (months): 12.0
Total project cost (EUR): 149924.0
EU funding (EUR): 149924.0
Participants: 1
Project status: CLOSED

The FNPMLS project (ERC n.648381) has successfully demonstrated that resonance ionization spectroscopy can be performed efficiently and with high resolution on an accelerated beam (CRIS). This novel and versatile methodology has been used to measure exotic nuclei down to rates of less than 20 atoms/second. In order to achieve these results the CRIS method has had to efficiently remove interference isotopes that would otherwise saturate the detectors. The key advantages of the method are its high selectivity, interference suppression and compact size. In principle it can be combined with mass spectrometry techniques such as ICP-MS and IRMS to enhance their respective sensitivity by more than three orders of magnitude in a compact table top device. This would have applications in the industries that utilize radioisotope detection for molecular labelling and dating. We believe that our methodology has the potential to significantly reduce the costs associated detecting isotopes such as 14C. In this project we will define and develop a commercialization strategy and effective route to market as well as produce a well defined IP position. A prototype device with autosampling capabilities will be constructed and used for benchmarking and validation tests that will further inform the marketing strategy. The final deliverables of this project will be a package consisting of a working prototype that demonstrates the ability to rapidly analyse biological samples and a commercialization strategy that has a clearly defined route to market and IP position.

Keywords: carbon dating,trace analysis,radioisotope detection,mass spectrometry,isotope ratio analysis
Fair, Effective, and Sustainable Talent Management using Conditional Network Embedding (FEAST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Belgium
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-04-01
End date: 2022-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The ongoing industrial revolution is the driver of a rapidly advancing shift in the division of labour between humans on the one hand and machines and algorithms on the other. This is the cause of significant challenges in the job market, such as the emergence of important skills gaps that need to be addressed by extensive upskilling or reschooling of workers. This requires considerable forethought and hence insight into the future job markets, as well as an understanding of how to best meet the job market's current and future needs. Substantial value is to be gained at all levels: from individual workers, over talent and human resources management within companies, to the determination of policy at governmental level. This Proof of Concept proposal will address these challenges by leveraging results from the ERC Consolidator Grant FORSIED which lend themselves well to a uniquely suited and elegant data-driven approach. In particular, the method Conditional Network Embedding (CNE) offers a powerful framework for making sense of the diverse information relevant to human talent and the job market. It provides a platform to tackle a diverse range of use cases in a uniform manner. Moreover, a distinguishing advantage of CNE is that it offers mechanisms for compensating for existing biases in the job market, ensuring fairness, non-discrimination, and inclusion when deployed to these use cases. During the project, a prototype platform will be developed, in tight collaboration with actors in the private and public sectors. This prototype will be evaluated, the IPR position investigated, and a market study conducted leading to a road to market strategy.

Keywords: data science,network embedding,fairness in data science,human resources,talent managment,labour,market,conditional network embedding,recommender systems
Silencing miR-199b to attenuate the progression of heart failure. (SIRENE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-09-01
End date: 2017-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cardiac hypertrophy is the principal risk factor for the development of heart failure and lethal arrhythmias. A complex web of interconnected signalling pathways has been implicated in hypertrophy and species of non-coding RNA molecules, microRNAs, have been shown to regulate these pathways. The recognition of microRNAs as potential therapeutic targets marks the principal step towards new therapeutic concepts. The SIRENE project represents the advancement of the therapeutic strength of miRNA silencing in clinically relevant heart failure models towards a valuable proposition for counteracting pathological hypertrophic signalling and heart failure development. In specific, during the related ERC CALMIRS project, it was found that sustained knockdown of endogenous miR-199b in the adult mouse heart in vivo leads to profound protective effects against symptoms of heart failure. Therefore, a new class of RNA antagonists, targeting miRNAs is powerful and holds great promise to become the next generation therapeutics. At this stage the newly developed antagonists are unique in their affinity and specificity for miR-199b and current data demonstrates a profound rescue by miR-199b antagonists on heart failure symptoms such as pressure overload induced cardiac morphological, histological, functional and molecular abnormalities in mice. The challenge of the SIRENE project is to identify immediate and longer term opportunities for commercialisation with high clinical and commercial feasibility. Therefore different business models will be studied in terms of market research, IP strategy and business development to eventually consolidate a commercial strategy and business case for presenting our business proposition to strategic partners or venture capitalists. Simultaneously, dose-range finding and efficacy studies will be conducted in rats, a clinically relevant and larger animal model of heart failure, for further preclinical development.

Keywords: mirna,antagomir,therapeutics,heart failure
Mitochondrial cristae form, function, and organization dependent upon metabolic sources and implication in heart failure (MitoFORMSinHF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

Every year 15.9 million people worldwide suffer a myocardial infarction (MI) causing sudden death in some individuals and predisposing survivors to recurrent MI’s and heart failure (HF), making ischemic heart disease the greatest contributor to human mortality. Research has uncovered molecular mechanisms that contribute to cellular demise during ischemic heart disease, however, to date there is no effective molecularly designed therapeutic. Recent studies implicate metabolism in ischemic cardiac injury pathogenesis. Optic Atrophy 1 (OPA1), a dynamin-related inner mitochondrial membrane (IMM) protein, orchestrates IMM fusion and maintains mitochondrial cristae form and structure. During MI disassembly of OPA1-containing oligomers ultimately induces apoptosis. Solute carrier family members (SLC25As) are thought to sense metabolic alterations and influence OPA1 oligomerization to regulate cristae function and shape, implicating metabolism in mitochondrial cristae formation. Whether metabolic sources or metabolic changes during IR injury contribute to disruption of OPA1 assembly, cristae maintenance, and apoptosis are yet to be elucidated. This is of great scientific interest because of the promising therapeutic potential to prevent pathogenic cristae remodeling and apoptosis during IR injury. I will work with state of the art imaging equipment within the Department of Biology at Padua University and receive expert training in mitochondrial biology under the supervision of Dr. Luca Scorrano in order to investigate if metabolic sources contribute to cristae maintenance and are implicated in ischemic cardiac injury. I will disseminate knowledge gained to American and European research societies focused on basic cardiovascular biology by attending conferences and the general public through the use of social media and scientific outreach. This proposals completion will launch my career as an independent investigator in Europe and forge international research connections.

Keywords: mitochondrial cristae junctions,ischemia reperfusion injury,mitochondria,apoptosis,basic cardiovascular sciences
Train Pantograph equipped with diagnostic system for reduction of faults and maintenance cost (DIAG-PANTOGRAPH)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A pantograph is an apparatus mounted on the roof of trains for collecting energy through contact with the overhead contact line. In Europe each year 5% of the running train fleet is affected by major faults on the overhead contact line, whose penalty cost amounts approximately at €40kper fault (4.6M€/year for a fleet of 2000 trains), plus the overall loss of time, efficiency, and quality of the service. DIAG PANTOGRAPH aims to launch to the market an innovative diagnostic pantograph and diagnostic kit for low speed trains (90% of the EU train fleet, 2.8k in Italy and over 14k estimated in EU28), introducing novel diagnostic and control features coupled with a new design of the contact strip and electronic monitoring technologies, strongly increasing the reliability and availability of pantographs and catenary, drastically reducing maintenance costs and the occurrence of failures of pantographs and catenary. Furthermore, the eco-design strip allows to reuse 100% of not worn carbon strip carriers (40 tons) and 100% recycling of wasted carbon (60 tons). Additionally cameras will be installed on drones by improving the quality of maintenance, while further reducing maintenance costs and occupational accidents. Average cost reduction for a large EU operator>3 M€/year). Since almost 90% of trains’ fleets is composed by low speed trains, the criticality of increasing the reliability and availability of the low speed rails system is evident. Rail freight industry reached 286 Bln€ in 2016 growing at a CAGR 7% while the passenger rail sector reached 210 Bln€ in 2015 growing at a CAGR of 24% since 2010. CONTACT received requests for quotations from key clients, such as SBB, Hitachi Rail and Bombardier, regarding the application of diagnostic systems for new and also in service pantographs. It foresees that DIAG-PANTOGRAPH supports the CONTACT growths generating within 5 years after project a total turnover of €32mln and a total cash flow of €6.9mln with a ROI of 477%.

Keywords: diagnostic pantograph,pantograph for low speed trains