Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Perivascular meningeal stem cells: a new player in the Neurovascular Unit. Characterization, modulation and therapeutic potential of perivascular meningeal stem cell activation in neurological disord (STEM-ACTIVATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 177000.0
EU funding (EUR): 177000.0
Participants: 1
Project status: CLOSED

The neurovascular Unit (NVU) consists of cerebral endothelial cells that interact physically and chemically with pericytes, astrocytes and microglial cells connected through the interactions with the basal lamina creating a functional barrier that regulates the movements of molecules into and out of the brain In the last two decades, the brain vasculature has increasingly been shown to have a key role in brain development, homeostasis, and disease. Recently the applicant has been identified a novel stem cell population with an exceptional neuronal differentiation potential in the perivascular space formed by extroflexions of meninges. The new cells named meningeal stem cells are activated by injury increasing their self renewal proliferation and migration properties and participate to the parenchymal reaction. In this project we will consider the perivascular meningeal stem cell activation in the context of the NVU interactions. We will challenge the hypothesis that the modulation of the meningeal stem cell activation can be done through the regulation of key metabolic factors and that this modulation can be exploit for the therapy of the neurological disorder. We will characterize and compare quiescent and injury-activated perivascular meningeal stem cells by using basic cell biology assay, trascriptomic and metabolic analysis. To specifically study meningeal stem cells interaction with the ECs and modulate their activation we will use RNA interference gene silencing, LV transduction and transgenic lines Moreover we will use spinal cord injury animal model and glioma animal model to test the therapeutic potential of meningeal stem cell activation. This multidisciplinary approach will shed light in how the meningeal stem cell interact with NVU and how their activation can be modulate as possible therapeutic target in the possible exploited of their activation can contribute to the neuro-angiogenesis in neurological disease.

Keywords: l312 stem cell biology,l511 neurological disorders,l406 cancer and its biologi
AGORA - Ancient Genomics of Rainforests (AGORA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 298932.6
EU funding (EUR): 298932.6
Participants: 1
Project status: CLOSED

Tropical rainforests from West and Central Africa are one of the most diverse but threatened ecosystems on Earth as a result of population growth, agriculture and forestry. Understanding the evolutionary history and ecological processes responsible for this vast biodiversity is thus an urgent task. However, biological research in these areas is extremely challenging due to bureaucratic reasons, conflicts or lack of infrastructures that difficult the access to the rainforest. As a consequence of the colonialism, Europe hosts the most complete botanical collections from tropical Africa. These collections are extremely valuable tools in botanical research since many of them have been collected before the independence in the Sixties in areas which are currently inaccessible. However, these specimens cannot be studied with traditional molecular methods, only suitable for modern samples with well-preserved DNA. The project AGORA - “Ancient Genomics of Rainforests” - intends to explore novel possibilities for the genetic study of these collections, in particular focusing on six widespread tropical tree legumes, with state-of-the art genomics and ancient DNA methodology in order to contribute to the reconstruction of the natural history of the rainforest ecosystem.

Keywords: natural sciences,biology,phylogeny,evolution,phylogeography,next-generation sequencing,african rainforests,botany,population genetics,ancient dna,genomics,plant systematic,glaciations,biogeography
Towards gene identification and personalized prophylactic medication for lithiopathies in lithium-using patients (LITHIOPATHIES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-05-01
End date: 2017-04-30
Duration (months): 36.0
Total project cost (EUR): 270786.3
EU funding (EUR): 270786.3
Participants: 1
Project status: CLOSED

Lithium is widely prescribed and the mainstay treatment for bipolar disorders. Unfortunately, lithium treatment often leads to adverse side effects (lithiopathies) like hypercalcaemia, nephrogenic diabetes insipidus and chronic kidney disease. Despite the above lithiopathies, cessation of lithium therapy is not an option for most patients, because there is no good alternative and the bipolar disorder has a larger impact on the patient’s quality of life. However, rationally-based medication for lithiopathies exists. As the lithiopathies are largely irreversible, the medication should be administered with the start of lithium treatment. However, prophylactic administration of these medications to lithium-using patients is undesirable, because not all patients develop lithiopathies. Therefore, to target for lithiopathy-specific personalized prophylactic medication for lithium-using patients, the aim of this study is to identify the susceptibility genes for development of the lithiopathies. To identify these susceptibility genes I propose to employ state-of-the-art haplotype association mapping (HAM) with mice at a world-recognized expertise centre for genetic research. As the used inbred mouse strains are fully genotyped, produce genetically identical offspring, and develop the lithiopathies consistently and on short term, HAM has clear benefits over genome-wide association studies in humans. At the return host, the role of identified susceptibility genes will be confirmed in cell and animal lithiopathy models and the corresponding orthologous genes in lithium-using patients will be tested for association with the lithiopathies. The project will not only provide the first steps towards personalized prophylactic medication for lithium users, but is also the perfect setup for a future scientific career of the applicant.

Keywords: lithium,bipolar disorders,nephrogenic diabetes insipidus,chronic kidney disease,hypercalcaemia,haplotype association mapping,susceptibility genes,personalized prophylactic medication
Mental representations of and adaptation to the speech signal transmitted via cochlear implants: How the impoverished signal finds its way to the mental lexicon (MARCI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 243847.8
EU funding (EUR): 243847.8
Participants: 1
Project status: CLOSED

Cochlear implants (CIs) allow many people to re-gain their speech perception. After implantation listeners need to adapt to a very different sensory experience and the CI transmits only parts and patterns of the information that is present in the acoustically rich natural signal. There are individual differences in the success of this adaptation. This study aims at examining causes of individual variation by relating speech processing with CI to models of speech perception in native and non-native listeners. This study will (1) examine how speech processing with CI fits within the architecture of models of speech perception and lexical access. Further, (2) the underlying mechanism of these models will be related to measures of cortical processing, in order to find physiological correlates that can give more objective measures of how new CI users adapt their speech processing to the device. (3) These measures will be applied to examine the course of speech processing in long-term users of CI and to track the progress of adaptation towards the prosthesis in listeners after new implantations. A set of behavioural experiments will examine the representations of speech in CI users. These experiments will be complemented by electrophysiological measures, and an eye-tracking study will examine the course of information processing. Long-term users of CIs will be compared with normal-hearing listeners, and a longitudinal study, run in parallel, will examine the changes in the cortical processing as new CI users adapt to the prosthesis. This study will bring together the insights from the framework of speech perception and word recognition with insights from applied engineering in medical environment. In this way the study will contribute to the frontier research that crosses the disciplines of basic cognitive science and applied technology. The study aims to give a comprehensive perspective on speech processing in CI and to track the way the CI signal maps onto the lexicon.

Keywords: s203 neuropsychology and cognitive psychology,s204 clinical and experimental psychology,speech perception and lexical access with cochlear implant,mechanisms of speech perception,plasticity
IRELAND AND ITALY’S MIGRATION EXPERIENCES SINCE 1945 COMPARED (IIMIGRATI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

Ireland and Italy saw significant proportions of their populations emigrate after 1945 before becoming host to substantial immigrant populations in more recent times. Despite the post-war exodus of millions of Irish and Italians, the literature has consistently failed to quantify the effect this had on Irish and Italian society and on the people who left. Not enough attention has been devoted to examining how Ireland and Italy have adapted to their transitions from near homogenous to heterogeneous societies in such a short period either. Immigrants today amount to over half a million in Ireland (12% of the Irish population) and 4.6 million in Italy (8% of the Italian population). These countries’ transitions from near monocultural to multicultural societies in such a short period demands scholarly attention. With the departure of young people from Ireland and Italy once again because of reduced opportunities at home, and with newcomers still arriving in search of a better life, this comparative project will provide a timely indicator of how emigration and immigration have shaped the two societies since 1945. The main objective of this project is to demonstrate how emigration and immigration have shaped Ireland and Italy since 1945. To fulfil this aim, the study will consider, in detail, (1) why so many people left Ireland and Italy after 1945. It will assess (2) the ramifications of the exodus of millions of Irish and Italians for the societies they left behind. It will explore (3) the effects that migration had on those departing their homes. In an attempt to fill a notable gap in the literature, this project will examine (4) how return migration and internal migration effected Irish and Italian society in the 1960s and 1970s. Relating to more contemporaneous developments, this study will endeavour to investigate (5) how Ireland and Italy have adapted to recently becoming hosts to sizeable numbers of immigrants.

Keywords: s106 globalization - migration - interethnic relations,s405 modern and contemporary history
Surface modified luminescent and magnetic gold nanoparticles as cellular targeting agents (NANOAGENTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 183504.6
EU funding (EUR): 183504.6
Participants: 1
Project status: CLOSED

The use of nano-sized particles is a new and promising topic in Chemistry, Medicine and Materials Science. Those nanoparticles have applications in many fields, from Computer Science to Medicine and the interest and the money invested for finding new applications grows every day. Gold is a very interesting material for designing nanoparticles (AuNPs) for medical applications due to its inertness, stability, spectroscopical properties, capacity for functionalization and biological compatibility. On the surface of AuNPs can be anchored chemical species with interesting properties. Doing this, the properties of the AuNPs can be modulated at will. Hereby we propose a 24 month research project for the design and developing of AuNPs with luminiscent properties and with potential applications for therapeutic use, drugdelivery, tissue imaging and cellular signalling. The major aim will be to signal cancer tissues for early detection and treatment of this disease. The surface of the AuNPs will be functionalized with luminiscent species that will target specific types of tissues and cells. This work will be carried out by Dr. S. Blasco, a young Spanish researcher whohas recently obtained his PhD and was formed as a Supramolecular and Bioinorganic Chemist in Prof. Enrique Garcia-Espana's group in the University of Valencia, Spain. The research work contained in this proposal will be done under the supervision of Prof. T. Gunnlaugsson, a renowned expert in the field.

Keywords: c140 supramolecular chemistry,c102 nanochemistry,c104 molecular architecture and structure,c127 materials for sensors,c132 coordination chemistry,c118 photochemistry
Mechanical activation of beta-catenin signalling (BCATENIN_MECHANICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

During embryonic morphogenesis, cells do not only generate forces necessary for shape changes and tissue movement but also sense and respond to the forces exerted on them by neighbouring cells and tissues. Recent studies demonstrate, that these forces can act as mechanical cues during development regulating cytoskeletal remodelling, cell proliferation and gene expression. However, in most cases the molecular mechanism by which cells sense and transduce a mechanical signal into a biochemical signal remains to be discovered. Therefore, my proposed project aims at identifying the primary mechanosensitive element during Drosophila gastrulation that initiates the activation of the beta-catenin pathway in stomodeal cells in response to mechanical strain that leads to the release of beta-catenin from adherens junctions (AJ) and its translocation to the nucleus, where it activates the transcription of a key regulator gene. In order to identify the molecular mechanism that translates a mechanical strain signal into a biochemical signal I will analyse the AJ complex in vivo for molecular changes in its dynamic interaction and conformation upon mechanical deformation during gastrulation. For this, I will make use of advanced fluorescent microscopy techniques in conjunction with classical biochemical assays. In addition, I will perform in vitro two cell assays to determine the strength and type of deformation needed to induce a conformational change. Ultimately, the information gained about the mechanosensitive element will be used to design a fluorescent probe to directly monitor the mechano-activation in response to the morphogenetic movements during Drosophila gastrulation. To my knowledge, this would be the first time in vivo to visualise directly the activation of a primary mechanosensor.

Keywords: l106 biophysics,l307 cell signalling and cellular interactions
Organizing the conference Week of Innovative Regions Europe (WIRE IV) 2013 (WIRE 2013)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Research Potential
Action type: Coordination and support actions
Countries involved: Ireland
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2013-01-01
End date: 2013-12-31
Duration (months): 12.0
Total project cost (EUR): 420654.8
EU funding (EUR): 400000.0
Participants: 1
Project status: CLOSED

A three-day conference, Week of Innovative Regions Europe IV (WIRE IV), is proposed for Cork, Ireland during Ireland’s Presidency of the European Union in 2013. The WIRE IV will focus on regional aspects relevant to the final stages of the Horizon 2020 design and legislative process and will be positioned primarily as an implementation focussed activity in the context of the Cohesion Policy 2014-2020 and Europe 2020. The organisers aim to contribute substantially to research, innovation and regional policy development and learning and to better position regional actors to enhance policy formation for effective regional development, while building on the outcomes of previous conferences in this WIRE series.

Keywords: european regional agenda and the eu presidency
Employing quantitative high-resolution imaging to understand mechanistic principles of ESCRT-mediated membrane fission in dividing cells (ESCRT HIGHRES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The ESCRT machinery is a multi-protein complex involved in membrane constriction and fission in a variety of processes in cells including receptor degradation, viral budding and cytokinesis. The mechanism by which ESCRT proteins drive membrane fission in cells is still largely unknown. Using super resolution fluorescence microscopy and quantitative live cells imaging I have recently mapped the spatiotemporal organization of ESCRTs in cytokinesis. The results identified a sequential recruitment of ESCRT proteins into a series of partially overlapping cortical ring structures and indicated the ESCRT machinery as the driving force for the membrane cleavage event required for cell separation. This work highlighted the advantage of using cytokinesis as a model system for studying ESCRT mediated membrane fission in a physiologically relevant context. In the proposed project I aim to elucidate how ESCRT function is regulated in cytokinesis in order to unravel the mechanism by which ESCRT proteins drive membrane fission in cells. Using super resolution imaging and quantitative live cell imaging of ESCRT proteins in genetically manipulated cells I will identify factors that regulate ESCRT function in cytokinesis and determine their effect on the spatiotemporal organization of ESCRTs in cytokinesis. Unraveling the regulatory basis for ESCRT function will underlie fundamental steps in the ESCRT pathway required for driving membrane fission in cytokinesis and will contribute critical information for understanding the mechanistic basis for ESCRT mediated membrane fission. The results of this work will have great implication to other ESCRT mediated cellular events including receptor degradation and viral budding.

Keywords: super-resolution imaging,live cell imaging,quantitative imaging,protein dynamics,structured illumination microscopy,sim,membrane fission,escrt function,cell division,cytokinesis,abscission
Fighting against obesity in Europe”: The role of health related-claim labels in food products. (OBESCLAIM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-09-01
End date: 2018-08-07
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The aim of this project is to investigate whether and how health-related claim labels in food products lead consumers to choose healthier food diet and therefore, nutritional and health labeling could be considered a valid tool to fight against obesity in Europe taken into account also consumers’ personal characteristics (socio-demographic, economic, nutritional and health status etc) and psychological and emotional factors. Therefore, different aspects will be investigated using a multidisciplinary approach: 1) The prevalence of the health-related claims labels in the food market; 2) The consumers’ understanding, use, perception and attitudes towards health-related claim labels; 3) How health-related claim labels in food products lead consumers to choose healthier food diet and, therefore, these claim labels potentially help to reduce obesity prevalence in Europe; and 4) The consumers’ preferences for health-related claim labels and the role of economics, social, psychological and emotional factors. The current work seeks to contribute to this cross-disciplinary stream by further examining food carrying on health-related claims as symbols perceived by European society, focusing on consumers´ emotions, and psychological and behavioural aspects, by using concepts of economics, behavioural economics and social psychology and by the implementation of focus groups, interview experts and field experiments

Keywords: e103,e108,experimental economics methods,obesity,health-related claim,multidisciplinary