Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PiedPiper®: smart pest control (PiedPiper)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global rat population is estimated to be at 60 Billion (i.e. 8 rats/human), causing growing socioeconomic, health and environmental problems. PiedPiper Technology is a revolutionary safe and humane pest control system for the control of rats, mice and other pest populations. It is the first solution that does not rely on the ingestion of toxin by rodents. It comprises a novel pest control device (PCD) incorporating an aerosol that delivers a metered dose of toxin onto the back of the rodent sufficient to kill in one application. The toxin passes through the skin and a quick and humane death results within 48 hours (compared to weeks with currently available products) to ensure that future populations of rodents will not develop resistance to the new toxin. This is a breakthrough versus the current multi-feed anticoagulants that are creating a growing problem of highly toxin resistant rodents (super rats). Our low cost formulation is based on cholecalciferol, which is lethal to rodents but safe for humans and other species. It has proven 100% effective in independent trials and, unlike current products, leaves no environmental residues. To gear up for a dominant position in the growing global rodenticides market- forecast to be worth over $ 1004.72 million by 2021- we will scale up our PCD for mass production, establish aerosol production, create an IoT platform of cloud connected devices for remote monitoring and predictive pest control management, obtain regulatory approvals for opening key markets in EU, US, Japan and Australasia. In the Phase 1, we will perform a market study to quantify the size of the global market and the segments we can target, expected market share, go-to-market strategy, revenue models and 5 year sales projections and KPIs. We will also define the most appropriate strategy for adding cognitive capability to an IoT platform of cloud connected PCDs for predictive pest control management to gain additional advantage in the market.

Keywords: pest control,rodents
Holistic Research into the story of buildings, objects and people in the high medieval period of Ireland, Britain and France from a gendered perspective (HeRstory)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Medieval archaeology has been strongly shaped by the predominance of male-biased perspectives within academia and the modern world. Castle studies in particular is a very male-dominated discipline with out-dated approaches which reproduce exclusively male-centred interpretations, thereby resulting in an impoverished understanding of how people interacted within these spaces. This study seeks to address this problem by taking a more human centred approach which reveals long ignored nuances in social practices. This will be achieved by examining the architecture, material culture (buildings and objects) and historical record of high medieval period England, Ireland and Normandy (1066-1398). HeRstory aims, through deep contextual analysis, to highlight how the material culture of this period both constructed and reinforced gendered roles in medieval society. This will challenge current perspectives in this area of medieval archaeology which imposes typical masculine views into the medieval past such as an exclusive focus on power/status or the tendency to predominantly view this era through the lens of warfare. For the first time, these new understandings of what it was like to be a woman or man in a medieval castle will be revealed. These new perspectives can be extrapolated outwards to achieve nuanced comprehensions of this time period which are far more inclusive/cognisant of gender constructs. This research challenges existing patriarchal and unilinear understandings of the medieval world by providing an insight into how people lived in and interacted with their environments such as the access to and position of rooms within the castle as well as the personal objects that surrounded them. In particular, this research significantly enhances our understandings of gender identities in Europe during this period. By moving to Reading's Dept. of Archaeology and working with Prof. Gilchrist, the researcher will significantly enhance her skillset and career.

Keywords: medieval archaeology,gender archaeology,interdisciplinary,identity,households,material culture,castle studies,medieval architecture,spatial analysis,ireland,europe,britain,france
Virtual Component and System Integration for Efficient Electrified Vehicle Development (VISION-xEV)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Spain,Italy,Germany,Germany,Italy,Italy,Austria,Belgium,Greece,Slovenia,Sweden,Switzerland,France
Call: Virtual product development and production of all types of electrified vehicles and components (H2020-LC-GV-2018, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 3995061.25
EU funding (EUR): 3995061.25
Participants: 15
Project status: CLOSED

The major challenge the European automotive industry is currently faced with is the 2020 CO2 fleet emission target of 95g/km and the envisaged further reduction of the CO2 emission limits in the European Union for the period after 2025. The European OEMs are also challenged by meeting Euro 6 tail pipe emission standards while already developing powertrains that need to fulfil future Euro 7 emission limits. In addition, the change of the emission test drive cycle from NEDC to WLTP and the implementation of real-driving emissions (RDE) imposes additional challenges onto the European car industry. The effort to meet the future fleet CO2 emission limits has been leading to the need for introduction of a broad range of electrified vehicle configurations into the portfolio of the European OEMs. Besides the increased development effort related to the electrified powertrain system itself, electrification also results in more derivatives from the standard platforms and vehicle models, which further increases the development effort and costs. An electrified powertrain is a highly complex mechatronic system, and meeting all functional and performance requirements efficiently demands a highly integrated development approach. Micro- and mild-hybrid architectures add moderate complexity to the conventional powertrain, however, the further step towards heavy electrification, aimed at a largely improved overall energy efficiency and unconditional emission legislation compliance under RDE conditions, requires advanced design and optimization methods and tools to master the related development challenges. This is exactly where the VISION-xEV project aims at providing its scientific and technical contribution: to develop and demonstrate a generic virtual component and system integration framework for the efficient development of all kinds of future electrified powertrain systems.

Keywords: electrified powertrain,use cases,demonstration,multi disciplinary modelling,multiphysics,e component models
individualizedPaediatricCure: Cloud-based virtual-patient models for precision paediatric oncology (iPC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Italy,Spain,Italy,Australia,Austria,Switzerland,Belgium,Slovenia,France,United States,Netherlands,Netherlands
Call: Exploiting the full potential of in-silico medicine research for personalised diagnostics and therapies in cloud-based environments (H2020-SC1-DTH-2018-1, 2018)
Start date: 2019-01-01
End date: 2023-11-30
Duration (months): 59.0
Total project cost (EUR): 15159851.0
EU funding (EUR): 14748400.0
Participants: 23
Project status: SIGNED

Effective personalized medicine for paediatric cancers must address a multitude of challenges, including domain-specific challenges. To overcome these challenges, we propose a comprehensive computational effort to combine knowledge-base, machine-learning, and mechanistic models to predict optimal standard and experimental therapies for each child. Our approach is based on virtual patient models–in-silico avatars whose analysis can inform personalized diagnostics and recommend treatments. Our platform will also allow care givers to query models and infer benefits and drawbacks for specific treatment combinations for each child. To construct these models, we will combine state-of-the-art computational methods and data from molecular assays, and clinical and preclinical studies. We will test their predictions prospectively on data from clinical trials and test therapies in pre-clinical settings. We will focus on a select panel of paediatric tumours including both high-incidence and high-risk tumour types. To accomplish our goals, we have assembled an interdisciplinary team consisting of basic, translational, and clinical researchers—all amongst the leaders in their respective fields—and established strong relationships with European Centres of Excellence, patient organizations, and clinical trials focus on personalized medicine for our proposed case studies. We will produce, assemble, standardize, and harmonize accessible high-quality multi-disciplinary data and leverage the potential of Big Data and HPC for the personalized treatments of European citizens. We will make our models and data available through a cloud-based platform, whose exploitation will be maximised through a collaboration with the European Open Science Cloud initiative. In summary, iPC will address the critical need for personalized medicine for children with cancer, contribute to the digitalization of clinical workflows, and enable the Digital Single Market of the EU data infrastructure.

Keywords: paediatric cancer,virtual patient,cloud computing,high performance computing,data harmonization and integration
Deep Brain: Decision Mechanisms in Deep Brain Networks (Deep Brain)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-12-01
End date: 2025-11-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Making everyday life decisions is vital to our survival and relies as much on cerebral cortex as on regions that reside Deep in our Brain, namely the subcortex. Studies on networks connecting small nuclei in the Deep Brain with cortical regions can provide key insights into learning, memory-guided, economic, and perceptual decision-making processes. However, the structural and functional organization of these processes is still incompletely understood, highlighting a knowledge gap in the field. The aim of this proposal is to reduce the gap in functional understanding by studying the mechanisms of different decision-making domains implemented in Deep Brain networks. The human brain consists of densely connected networks of interacting areas and nuclei, and while the cerebral cortex has been mapped with great precision, research on the human subcortex has been relatively sidelined (Forstmann et al., Nat Rev Neurosci, 2017). The subcortex contains hundreds of small grey matter nuclei, which take up approximately 1/4th of the entire human brain volume. Importantly, only approximately 7% of these nuclei are currently accessible in standard human brain magnetic resonance imaging (MRI) atlases. Major ongoing efforts in my group have focused on structural imaging of the subcortex, thereby removing an important technical barrier. These efforts have paved the way for functional studies on the role of Deep Brain in decision making as described in the current proposal. Ultra-high-field (UHF) 7Tesla (T) MRI and one of the three world-wide available Connectom MRI will be used to investigate decision mechanisms in Deep Brain networks. Three projects are proposed using a strong theory-driven and statistically high-powered model-based approach to combine beyond the-state-of-the-art techniques ranging from cognitive neuroscience, experimental psychology, to quantitative modeling.

Keywords: model based cognitive neuroscience,decision making,magnetic resonance imaging
Characterization of the developmental mechanisms ensuring a robust symmetrical growth in the bilateral model organism Drosophila melanogaster (GrowthDevStability)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

The overarching objective of the proposed project is to find how and when organs asses their growth status and which mechanisms are deployed to ensure fine size adjustment during normal animal development. As a model system, I will study the symmetrical growth of D. melanogaster, where the signaling hormone Dilp8 has been described as a central player to ensure developmental stability. However, Dilp8 regulation and mechanism of action remain elusive, providing an unprecedented framework to inquiry about the general phenomenon of growth adjustment. I will study when Dilp8 is required and in which organ it is produced during normal development. Also, I will identify signaling pathways regulating Dilp8 expression and the downstream effectors required for its action. This project will allow me to define for the first time how a systemic signal is activated and functions to adjust symmetrical growth in a bilateral model organism. The new concepts introduced by my investigation may help to better understand the pathophysiology of childhood growth disorders, as well as the growth disturbances observed in cancer survivors.

Keywords: developmental stability,growth coordination,bilateral symmetry
Equidae Hindgut Anaerobic Fungi: A key unexplored taxa of central importance to dietary fibre degradation (EQUIANFUN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2019-05-11
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

EQUIANFUN is a strategic research and training alliance I have assembled to catalyse the development of my new career path in comparative herbivore gut microbiology, and addresses a major nutritional challenge facing the equine community. The hindgut microbiota of equines enables forage utilisation; however, the limited efficiency of this process currently requires that the diets of many equines are supplemented with energy-dense concentrates in order to meet their dietary energy requirements. This practice can disturb the equine hindgut microbiota, resulting in the development of gut-mediated diseases which are a major health and welfare issue and economic cost to the equine community. Despite the fact that anaerobic fungi (AF) are the most effective of the fibre-degrading gut microbes, they have been largely overlooked in equine gut microbiology studies to date. Therefore research into this under-explored area will significantly advance the ability to increase the efficiency of forage utilisation in equines, minimising the need for concentrate supplements. Drawing on my core skills base, and utilising internationally leading expertise and facilities in gut microbiomics and animal nutrition at Wageningen University, EQUIANFUN establishes new baseline knowledge of the phylogeny, community structure, physiology and nutritional impact of equine hindgut AF. In addition to generating top quality research findings of applied impact, EQUIANFUN deepens my skills and competencies whilst broadening my research expertise and network beyond its current rumen focus. Furthermore the integrated role of the two partner organisations, Utrecht University and the Donkey Sanctuary, widens the scope of EQUIANFUN to also include the health and welfare of all domesticated equids. In summary, EQUIANFUN is pivotal to the development of my new career path and ability to attain professional maturity as an internationally leading researcher in comparative herbivore gut microbiology.

Keywords: equine,anaerobic fungi
Disentangling variation: A crosslinguistic investigation of bilingualism and non-standardization (DIVA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-07
End date: 2019-08-06
Duration (months): 24.0
Total project cost (EUR): 196400.4
EU funding (EUR): 196400.4
Participants: 1
Project status: CLOSED

This project will investigate the ways in which variation in the linguistic input affects the trajectory of language development and its final outcome. This exploration of language variation and its contributing factors will bring together both the sociolinguistic and the neurocognitive aspects of the human ability to use language, through adopting a cross-linguistic perspective. Acceptability judgment tasks will be the vehicle to test different domains of grammar, such as word-order patterns, adjective orderings, and grammatical illusions, across different linguistic communities in Scandinavia, Cyprus, and Greece. Through examining acceptability judgments in neurotypical adult populations, this project will foster a novel, three-way comparison across (i) monolingual, bilingual, and bilectal speakers, (ii) three domains of grammar, (iii) varying developmental trajectories within the bilingual population, including heritage language learners and L1 attriters. The combination of on-line and off-line measures will shed light on how different domains of grammar are processed by the monolingual and bilingual mind and elucidate whether some or all types of bilingualism confer a cognitive advantage in this processing. Two key objectives of this project are the investigation of both standard and non-standard varieties and the promotion of linguistic diversity. Ultimately, the findings of this project will generate substantive, empirically informed hypotheses about human language and the bilingual mind. Within the present context of increased multilingualism throughout the lifespan these results are likely to achieve a marked scientific impact.

Keywords: language variation,bilingualism,heritage language acquisition,l1 attrition
The dawn of writing in Western Mediterranean: a comparative approach to the Iberian epigraphic corpus (ZEPHYROS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-15
End date: 2017-09-14
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 2
Project status: CLOSED

This project proposes a study of all known Iberian inscriptions (about 2.000 documents dating from the 5th century BC to the 1st century AD) in a comparative and interdisciplinary perspective. The study of the Iberian corpus will be set in a broad cultural context, including the rise of the first Western written traditions and their linguistic and cultural contacts. I will focus on issues such as the relationship between text and object, the Iberian adoption of exogenous epigraphic models (mainly Phoenician/Punic, Greek and Latin), and the level of literacy within the male and female spheres of this society. Although the Iberian language in not yet fully deciphered, its epigraphic texts represent a cornerstone of the ethnological and cultural understanding of the protohistoric peninsular peoples and their insertion within the Mediterranean world. For the time being, however, there is no comprehensive study of the Iberian corpus, which has grown considerably over the past decades. On the other hand, there has been a tendency to study the Iberian world and its written culture in an overly isolated way, without sufficiently considering the panorama of neighbouring territories, which provide significant parallels. The specific objectives of this project can be synthetized as follows: publication of the entire corpus of Iberian inscriptions according to current academic criteria, including a digital open access version; linguistic analysis of these texts with a special attention to the cultural context in which they were produced; study of the Iberian written culture in a broad cultural context, including neighbouring territories such as Northern Africa. This project will therefore contribute to the understanding of the Iberian language as well as the circulation of cultural models within the Western Mediterranean. It will ultimately represent an innovative step toward the comprehension of the birth of European identities.