Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hydration Dynamics of Antifreeze Proteins (AntWatFre)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Antifreeze proteins (AFPs) and antifreeze glycoproteins (AFGPs) enable the survival of various organisms in freezing or subfreezing habitats. Even millimolar concentrations of these proteins are sufficient to lower the freezing temperature by several degrees. To reach a similar freezing point depression using sodium chloride would require molar concentrations. Nowadays AF(G)Ps already find applications in food industry, for instance to prevent recrystallization in ice cream and have great potential in medical applications (cell & organ storage, operations at low temperature). Protein-water interactions are of general interest owing to the importance of protein hydration for protein function; AF(G)Ps form an extraordinary example of this coupling that is sufficiently strong and specific that the protein controls macroscopic thermodynamic properties of water. Despite their importance in nature and their industrial relevance, the mechanisms by which AF(G)Ps depress the freezing point are still poorly understood. Although substantial information presently exists on the static protein structures and thermodynamic properties of these systems, molecular scale information on the dynamics of the conformations of the AF(G)Ps, their hydration shells and their binding to ice, is extremely scarce. Here we propose to study the molecular mechanisms by which AF(G)Ps lower the freezing temperature with advanced nonlinear spectroscopic techniques like 2D polarization-resolved vibrational spectroscopy and surface sum-frequency generation. These techniques enable the label-free study of the structural dynamics of the AF(G)P conformations, their hydration shells and their mechanism of binding to the ice surface. They will be used to study several key elements in the functioning of AF(G)Ps.

Keywords: antifreeze proteins,vibrational spectroscopy,hydration dynamics
Sustainable Urban Form For Integrated Climate Change Mitigation Solutions (SUFFICCS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-04
End date: 2024-01-03
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Urbanisation is a global trend poised to continue throughout the twenty-first century. Levels of urbanisation and various aspects of urban form (including density, land-use diversity, street connectivity, and access to public transit and jobs) have been demonstrated in many empirical studies and theoretical models to be important determinants of energy use and greenhouse gas emissions from buildings and transport. However, urban dimensions are absent from models projecting global energy and emissions by country and sector. This omission underrepresents the significant connection between urban dynamics and future emission trajectories, and hinders identification of integrated planning strategies for maximum emission reductions. The main objective of SUFFICCS is to develop and demonstrate a framework for integrated modelling of service levels (m2 floorspace, passenger-km), energy demand, and emissions from urban buildings and transport systems. This modelling framework will be developed using data from urban regions of European countries, and designed for integration with a global dynamic material flow analysis model. Emissions from producing new buildings, infrastructure, and transport equipment will be included, enabling a comprehensive assessment of climate change impacts and mitigation potential of future urbanisation. The incorporation of urban dynamics into energy and climate models, and the linking of transport and buildings sectors through joint dependencies on urban form will represent major advancements in modelling capabilities. These advancements will facilitate assessment of urban and national emission trajectories under various scenarios of urban form, with unprecedented integration of buildings and transport sectors. The aims of SUFFICCS resonate with targets of the EU Green Deal relating to cities, buildings and transport, and the outputs will aid planners and policymakers to identify integrated strategies which maximise climate change mitigation.

Keywords: material flow analysis,demand side mitigation of climate change
INCUBATOR ACADEMY MODEL FOR GREEN ECONOMY AS PEER LEARNING ACTION FOR INNOVATION AGENCIES (I AM GREEN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Israel,Ireland,Italy
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2020)
Start date: 2021-02-01
End date: 2022-01-31
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The overall objective of the I AM GREEN project is to co-design a widespread incubator and start-up academy model addressed to support entrepreneurs in all steps to take from the business idea design to market penetration, passing through a tailor-made training and incubation path that gives special attention to sustainable development and ways to “greening” the business. The project aims to contribute to the qualitative improvement of services offered to start-ups thanks to an integrated approach that guides entrepreneurs along all steps of the entrepreneurial path with a special focus on training and financial needs. The designed incubation model will be a virtual and physical space where Innovation & Development Agencies, Research & Training Centres and Start-up Incubators work together to assist the entrepreneur with a 360-degree approach. The idea is to develop an incubation model where start-ups are incubated in a well-settled company that introduce them in the market. The rationale of incubation is the sharing of the same value chain and/or the possibility to create synergies such as industrial symbiosis projects. The general objective is to offer a more fertile environment for new business ideas birth and growth as well as creating new business opportunities leveraging on potentialities to greening processes, supporting their development at EU level acting as a real driver for innovation and sustainable growth for Europe. This will be done by improving the support that is available to them, functioning as a think-tank that identifies needs and prepares new directions within start-up creation support as well as available training and consulting services.

Keywords: incubators,start up,academy,peer learning,twinning,innovation
Centre of Excellence in Multifunctional Materials for Industrial and Medical Applications (NOMATEN)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Poland,Finland,Poland,France
Call: Teaming Phase 1 (H2020-WIDESPREAD-04-2017-TeamingPhase1, 2017)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 399745.0
EU funding (EUR): 399745.0
Participants: 4
Project status: CLOSED

The overall objective of the NOMATEN project is to establish a Centre of Excellence (CoE) in Multifunctional Materials for Industrial and Medical Applications that will exploit unique nuclear research infrastructure and expertise from Poland and Europe. The long term vision for the NOMATEN CoE will be to provide world-class research and development of innovative multifunctional materials – materials combining advanced structural and functional properties – for industrial and medical applications. To achieve this vision, the CoE will be created by three consortium partners with complementary facilities and expertise: • Narodowe Centrum Badań Jądrowych (NCBJ), Poland; • Commissariat à l’énergie atomique et aux énergies alternatives (CEA), France; • Teknologian Tutkimuskeskus VTT Oy (VTT), Finland. They will be supported by Narodowe Centrum Badań i Rozwoju (NCBiR) - an implementing agency of the Ministry of Science and Higher Education of Poland – which is the fourth consortium partner. The consortium partners will develop and execute a long-term science and innovation strategy for the CoE - based on a SWOT analysis of NCBJ - that focuses on two strategic research and innovation topics: • Novel high-temperature, corrosion and radiation resistant materials for industrial applications • Novel radiopharmaceutical materials for medical applications The consortium partners believe that leveraging their combined research and innovation capabilities will: • Enable more efficient usage of their research infrastructure and equipment • Create more attractive opportunities to educate and train young researchers • Foster an innovation ecosystem that increases technology-transfer for industrial and medical applications • Create the critical mass to win more competitive research funding.

Keywords: multifunctional materials,nuclear power,radiopharmacology
EU Fruit Network (EUFRUIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Coordination and support actions
Countries involved: Germany,Germany,Italy,Germany,Spain,Spain,Italy,Belgium,Romania,Switzerland,Hungary,Lithuania,Belgium,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Closing the research and innovation divide: the crucial role of innovation support services and knowledge exchange (H2020-ISIB-2015-1, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1839737.5
EU funding (EUR): 1734237.5
Participants: 23
Project status: CLOSED

The European Fruit Network (EUFRUIT) includes 12 countries focussed on 4 thematic areas of critical for the competiveness and innovation potential of the European Fruit sector: i) new cultivar development and evaluation; ii) minimise residues on fruit and the environment; iii) optimising storage and fruit quality; iv) sustainable production systems. EUFRUIT will coordinate and support innovation through developing a framework for relevant stakeholders and it will establish a systematic approach for knowledge gathering and dissemination. The systematic approach includes: i) scanning & synthesis via 4 expert groups who scan state-of-art knowledge, practises and technologies and synthesise the material to identify key areas of learning and best practise approaches at a European level. ii) showing & sharing will deliver outreach/dialogue at a national level through establishment of local ‘operational groups’. An online Knowledge Platform will hold all outreach material, outreach activities include; 100 industry publications, 90 technical bulletins, 25 flyers/newsletters, 60 seminars, 160 field based meetings, 25 conference plus 12 events aimed at the general public. iii) sustaining the network will occur through long-term integration of the assembled EUFRUIT network in future actions. The overall outcome of EUFRUIT will be establishment of a framework and a systematic approach that together builds a bridge across the ‘valley of death’. This bridge will secure a direct path for new knowledge in the future and reduce the likelihood of repetition of research at a national level. The European fruit sector will have ready access to up-to-date information to implement and value will be created both for the industry with respect to competitiveness, sustainability and efficiency and society through ensuring the security and safety of fruit; underpinning human health and wellbeing.

Keywords: horticulture,fruit,improved cultivars,minimizing residues,storage,quality,sustainability,best practice
a.r.t.e.s. EUmanities - European Graduate School for the Humanities Cologne (artes EUmanities)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany,Spain,Italy,Germany,Belgium,Bulgaria,Poland,France,United States,Canada,Mexico,Chile,United Kingdom
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2015, 2015)
Start date: 2017-04-01
End date: 2022-03-31
Duration (months): 60.0
Total project cost (EUR): 4708800.0
EU funding (EUR): 2354400.0
Participants: 26
Project status: CLOSED

artes EUmanities offers a doctoral programme (DP) with a mandatory mobility phase, as part of the established artes Graduate School for the Humanities Cologne (AGSHC). Designed around the needs of each individual Early Stage Researcher (ESR) in the Humanities, it will provide places for up to 10 ESRs every year for 3 years. EUmanities relies on a structured but flexible bottom-up approach, providing an interdisciplinary DP for the entire Humanities that supports ESRs to design their own individual research and career development. Thanks to a wide-spread network of regional, European and global networks of excellent research, academic and intersectoral partner organisations, they will learn to work discerningly and decisively, think and engage beyond disciplinary, national and sectoral boundaries. artes EUmanities will be implemented in accordance with the targets of the Horizon 2020 objectives regarding excellent research, stable working conditions and the implementation of the triple “i” dimension through: 1) two international mobility options (a global outgoing phase of 18 months – artes global, or an inner-European outgoing phase of at least 12 months - artes EU); 2) extensive guidance by an interdisciplinary and international team of 3 supervisors and within multidisciplinary Graduate Classes; 3) support for a prompt transition into subsequent career stages thanks to the career development programme and a close cooperation with various intersectoral partners. artes EUmanities will guarantee a sustainable impact on the whole institutional structure of the ASGHC, transforming it into an excellent European graduate school with a strong international outreach and a distinctive interdisciplinary approach. It will offer Europe a leading model for innovative DPs and research training that will empower ESRs in the Humanities to become aware of their own potential in mediating sensitive and complex issues to make them accessible to different addressees.

Keywords: humanities,interdisciplinary graduate classes,european and global mobility,joint supervision agreements,intersectoral strategy for the humanities,public engagement for the eu
RAS/C-RAF interaction: A new pharmacological target in Kras-driven lung cancer. (IVORIaN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Lung adenocarcinoma is the most frequent subtype of lung cancer and patients harbour activating mutations in the KRAS gene in approximately 25% of the cases. Unfortunately, regardless of the outcome of recent studies identifying specific KRASG12C inhibitors, so far, oncogenic KRAS is not a druggable target yet. The best-characterized KRAS effector pathway, the ERK cascade consists of RAF, MEK and ERK proteins that can be inhibited with small molecules targeting their kinase activities. As the development of RAF and MEK kinases inhibitors progressed, feedback loop reactivating the ERK cascade have emerged, inducing resistance to treatment. Thus, new innovative strategies are needed to achieve a more long-term inhibition of this signalling pathway, while reducing detrimental side effects due to MAPK inhibition in normal cells. It has been described more than 20 years ago that RAF directly interacts with RAS through its Ras Binding Domain (RBD), and many research groups have been trying to disrupt this interaction developing allosteric inhibitors as a cancer therapy. At the moment, those molecules need to be improved in order to achieve a strong inhibition of this pathway. Surprisingly, no mouse model actually demonstrates the requirement of RAS/RAF interaction during KRAS-induced lung tumourigenesis. Here, we propose to investigate this crucial question using a new mouse model allowing us to conditionally disrupt RAS/RAF interaction in vivo. Using the leading mouse model to study lung cancer (LSL-KrasG12D/+; p53-/- mice), we will take advantage of both Cre/LoxP and FLIPo/Frt technologies to investigate the role of RAS/RAF interaction during lung tumours maintenance, as well as its function in tumour/host crosstalk and normal physiology. All together, these investigations will provide important insights into the clinical relevance of developing RAS interaction inhibitors for the treatment of RAS-driven tumours.

Keywords: nsclc,lung adenocarcinoma,genetically engineered mouse model gemm,protein protein interactions,pharmacological target
Protecting Personal Data Amidst Big Data Innovation (PROTECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Ireland,Germany,Ireland,Belgium,Netherlands,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-08-01
End date: 2024-01-31
Duration (months): 54.0
Total project cost (EUR): 3701255.76
EU funding (EUR): 3701255.7600000002
Participants: 12
Project status: SIGNED

The overall goal of PROTECT is to grow a new generation of 14 Early Stage Researchers (ESRs), as PhDs graduated via a unique multidisciplinary, inter-sectoral and international European Training Network ETN). The network will investigate the protection of rights and interests of individuals and groups impacted by the continuous large-scale analysis of personal data, while still enabling the economy and society to benefit from rapid innovation in digital applications that collect and use this data. The PROTECT ESRs will implement a Personal Career development Plan (PCDP) that will enable them to integrate and apply arguments, analyses and tools from across the fields of law, ethics and knowledge engineering, so that they can take on leading research and data scientist roles within digital services industry and public policy sectors too address challenges of data protection, data ethics and data governance. The rate of technological innovation, now accelerated by big data and machine learning invariably outpaces public policy debate and the development of new regulation for the protection of personal data. This come as the scale and social impact of data analysis is rapidly increasing. Tech companies, especially SMEs, face complex legal and ethical implications resulting from the collection of personal data from users. The pace of change and its complex technical nature serves to overload individuals and enterprises in considering the impact of use of their personal information, especially when this use also delivers attractive personalisation of services. PROTECT ESRs will develop new ways of empowering users of digital services to understand the risks they take with their rights and interests when they go online and offer new ways to enable companies to incorporate privacy, data protection and broader ethical considerations into the development of digital services, even as they are face growing commercial and competitive demands to exploit personal data.

Keywords: privacy and data protection law,ethics of technology,knowledge engineering
NB-IoT Robust Tracking and Monitoring Solution (stalkIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Solutions for asset tracking and monitoring are mainly powered by ordinary mobile data connectivity such as 2G and 3G with high subscription and maintenance costs every year. This lack of affordability significantly decreases the number and types of assets that businesses can pay for monitoring; which especially affects SMEs and verticals with a low profit margin like waste management or construction and demolition. Consequently, they suffer usually equipment theft, loss and poor asset management. StalkIT makes asset tracking & monitoring affordable for SMEs and opens the market to new asset types, including much smaller, lower-value items. However, reliability is always a key issue for new technologies. For this reason, we have tailored our innovation for harsh environments as proof of concept for the application of our technology in other verticals. Based on the brand-new NB-IoT & LTE-M (LPWA) technologies, StalkIT is a full-stack solution formed by two ground-breaking pillars: -A robust tracking device 10 times less expensive than current offerings designed to support IoT connectivity on lower-powered mobile data networks. This allows a practically maintenance free since the battery lasts up to 10 years. Besides, it is tailored to harsh environments (Rated IP67). As such, it suits applications in the waste recycling sector. -A cloud platform which allow users have access to a monitoring software though mobile App and web portal. This includes a multi-layer map showing live and historic devices position, list of all devices sorted at customer’s preference, user administration and control and overview of all sensors.

Keywords: nb iot,lte m,lpwa,asset tracking