Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Diabetic Brain (THE DIABETIC BRAIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 246940.4
EU funding (EUR): 246940.4
Participants: 1
Project status: CLOSED

Type 2 diabetes is one of the most common chronic diseases in the world, and the number of those affected has been raising dramatically in recent years. In type 2 diabetes the body fails to use insulin effectively, which leads to the chronic increase in blood glucose that characterises the disease. It is not known why the body becomes resistant to insulin but evidence suggests that an imbalance between energy intake, storage, and expenditure can lead to obesity and insulin resistance. Thus, to understand the origins of diabetes it is fundamental to understand how the organism evaluates and controls its metabolic requirements. The hypothalamus in the base of the brain is essential for orchestrating such functions, aided by specific cell groups which detect changes in extracellular levels of nutrients. I suggest that a disruption in these sensing mechanisms in the hypothalamus can lead to a metabolic imbalance in the body. In this project I will study the properties of hypothalamic nutrient-sensing neurones in a model of obesity and insulin resistance. A novel approach that will combine state-of-the-art cell physiology, biochemistry, cellular and mitochondrial bioenergetics, and molecular imaging methods in a multidisciplinary environment will be key to unravel some of the mechanisms used by nutrient-sensing neurones in health and disease. This project will thus provide a better understanding of the role of these mechanisms in obesity, insulin resistance, and diabetes. That knowledge will potentially open new avenues to the development of novel strategies for treating metabolic diseases.

Keywords: health sciences,neurophysiology,chronic diseases,diabetes,obesity,metabolism regulation,nutrient-sensing mechanisms,hypothalamus,electrophysiology,imaging,translational research
The role of EGF/ERK signaling pathway during the wound healing response in Drosophila and zebrafish epithelia (WOUNDHEALINGEGF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 146783.6
EU funding (EUR): 146783.6
Participants: 1
Project status: CLOSED

Epithelia act as physical barriers that protect living organisms from the surrounding environment. Therefore, the organization and homeostasis in epithelial tissues requires robust mechanisms that assure their integrity in a variety of biological situations, such as normal cell turnover, inflammation and injury. The cell biology of wound healing has started to be understood but there are still many open questions and the signaling cascades that regulate this process are largely unknown. An intriguing and crucial question is what is the nature of the earliest signals that activate the different events of a wound response. In this project, we will study the signaling pathways required for the activation of the wound response. Our main focus will be the role of EGF/ERK signaling, which we propose to be one of the first pathways to be activated in this process. We also plan to determine the primary signals activating the wound response cascades. We will use the Drosophila embryonic and pupal epithelia as our primary model systems, but will also investigate whether these signaling mechanisms are conserved in vertebrates, by studying the wound healing process in zebrafish embryonic epithelia.

Keywords: wound,healing,epithelia,resealing,egf,erk,drosophila,zebrafish
Visual-spatiotemporal integration for recognition (V-STIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-11-01
End date: 2012-10-31
Duration (months): 24.0
Total project cost (EUR): 181103.2
EU funding (EUR): 181103.2
Participants: 1
Project status: CLOSED

Detecting and identifying targets in cluttered scenes is critical for successful interactions in the complex and dynamic environments we inhabit. Despite the ease and speed with which we recognize objects, visual recognition entails the computationally challenging task of binding relevant features together for the perception of coherent meaningful objects. Most work on visual integration focuses on spatial binding processes. However, detecting dynamic objects in cluttered scenes entails storage of image fragments in memory and integration across time. Here we propose to investigate the mechanisms that mediate integration across space and time. We will exploit the contour slit-viewing paradigm: that is, an object moving behind a narrow slit is still perceived as a whole. In task 1, we will characterize quantitatively the ability for slit-viewing perception and generate a computational model describing the principles that guide spatiotemporal integration. In task 2, we will test for similarities and differences in the neural substrates underlying spatial and spatiotemporal integration using conventional GLM and advanced multivariate analyses. In task 3, we will test for cortical regions that mediate perceptual deformations under slit-viewing. Task 4 will use precise retinotopic mapping to investigate the memory store processes engaged in spatiotemporal integration. Finally, in task 5 we will employ simultaneous EEG-fMRI recordings to examine the dynamic information processing of spatiotemporal integration and the interactions within the cortical circuit involved. The proposed work programme will devise a new paradigm and take advantage of recent advances in multimodal recordings (EEG-fMRI) and advanced computational analysis methods to explore the neural mechanisms of spatiotemporal integration for the first time. This interdisciplinary work will offer new insights into the neural machinery that underlies our ability to recognize dynamic objects in cluttered scenes.

Keywords: slit-viewing,spatiotemporal integration,visual memory
Extremal Kaehler metrics and geometric stability (CAMEGEST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-09-15
End date: 2013-09-14
Duration (months): 36.0
Total project cost (EUR): 228804.7
EU funding (EUR): 228804.7
Participants: 1
Project status: CLOSED

The problem of finding canonical Kaehler metrics on compact manifolds is central in Kaehler geometry. Since the pioneering work of Calabi, the existence problem for Kaehler-Einstein (and more generally constant scalar curvature, or even extremal Kaehler) metrics has attracted considerable attention. In this circle of ideas the most fascinating problem is represented by the so-called Yau-Tian-Donaldson conjecture, which predict the equivalence between the K-polystability of a polarized manifold and the existence of a constant scalar curvature (or more generally extremal) Kaehler metric in the polarization class. In this vein we propose the following three main research objectives: first, find an algebraic criterion for K-stability of polarized manifolds; second, study the effect of symplectic reduction on relative K-stability; third study the Calabi flow (in particular on toric manifolds) adapting the La Nave-Tian and Arezzo-La Nave approach to the Kahhler-Ricci flow. We propose to develop the research at Princeton University, under the superfision of prof. G. Tian, and Parma University, under the supervision of prof. C. Arezzo.

Keywords: kaehler geometry,extremal metrics,algebraic geometry,geometric analysis,calabi flow,yau-tian-donaldson conjecture,k-stability
Dynamic and multi-nuclear magnetic resonance imaging for the assessment of nutrient and drug delivery in the human gastrointestinal tract (GI-MRI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-08-01
End date: 2012-07-31
Duration (months): 24.0
Total project cost (EUR): 180470.8
EU funding (EUR): 180470.8
Participants: 1
Project status: CLOSED

Understanding the function of the gastrointestinal (GI) tract and its relation to abdominal symptoms and digestion is of fundamental importance in clinical medicine. Existing techniques are not able to describe the integrated, regulated mechanism by which foods are digested and drugs are delivered to the bowel. It is for these reasons that the causes of abdominal symptoms often remain unclear and that oral therapies for systemic conditions complicated by GI dysfunction are ineffective. This project will develop and apply MRI technology to assess the flow, mixing and transit of nutrients and oral drugs through the GI tract. Dynamic 1H-MRI will provide a comprehensive assessment of GI function and be combined with novel 19F-MRI that follows the passage of GI contents. Results will be validated and extended by 13C breath testing. The primary objective is to develop multi-nuclear MRI for use in physiologic measurements of GI function (1H-MRI) and delivery of nutrients/drugs (19F-MRI). This includes the optimization of accelerated 3D 1H-MRI for detecting GI function in long bowel segments and 19F-MRI utilizing (nano-)capsules containing a stable fluorocarbon as an oral contrast agent. This technology will be applied in clinical studies of two important diseases to assess whether these developments provide novel insight into the mechanism of disease: (1) Diabetic Mellitus, to assess how gastroparesis leads to abnormal nutrient delivery and impaired glycaemic control. (2) Parkinson’s Disease, to assess how gastric dysfunction affects the delivery and absorption of levodopa and its efficacy for treatment of tremor and rigidity. This project will maintain the leading position of European researchers in MRI assessment of GI function, a technology that is likely to enter clinical practice in the next years. It will increase knowledge about the identification and management of GI complications in DM and PD, chronic diseases that are stated priorities of the FP7 work program.

Keywords: biomedical engineering,gastroenterology,magnetic resonance imaging,gastrointestinal function,multi-nuclear imaging,nutrient delivery,drug delivery,digestive health,image processing
Theory of Quantum Computation and Many-Body Simulation with Novel Quantum Technologies (THECOSINT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-31
End date: 2013-01-30
Duration (months): 24.0
Total project cost (EUR): 165540.8
EU funding (EUR): 165540.8
Participants: 1
Project status: CLOSED

The recently emerged discipline of quantum information promises to have a profound impact on the information technologies that so deeply permeate our society. The search for an actual quantum information processor involves different physical systems, thus motivating an exciting interdisciplinary research ground. In this framework the present project will involve contributions from various branches of quantum science, with emphasis to cutting-edge quantum technologies in condensed matter and quantum optical systems. The project -besides enhancing the competence diversification of the candidate- is properly tailored for his scientific trajectory which, starting from investigations on quantum information and quantum optics, aims at progressively acquire expertise in the field of many-body systems. This, in turn, is expected to strongly support the candidate in attaining a leading independent position. Specifically, the main objective of the project is to investigate theoretically novel approaches to quantum simulators (QS) and quantum computation (QC) properly tailored for new quantum technologies. The two major quantum information paradigms will be considered: discrete and continuous variables. The first goal is to individuate the benefits offered by novel technologies such as circuitQED, microcavities, and nano-elecromechanical oscillators. Then these technologies will be exploited to find novel proposals for QS of strongly interacting many-body systems (both spin and bosonic systems). The presence of thermal noise will be addressed by using new ideas emerged in the field of quantum thermodynamics. Finally, the last goal is the search for new continuous variable schemes for QC. We will focus on measurement based QC, a new computation paradigm which exploits the synergies between quantum information and many-body systems. To face the drawbacks that historically affect continuous variable QC the benefits offered by the above mentioned technologies will be harnessed.

Keywords: quantum information theory,entanglement in many-body systems,quantum optics,quantum computation theory
Design and development of an Adaptive, Smart and Eco-efficient Test Bench for synchronized testing of linear actuators in the aeronautic sector (ASE-TB)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2009-11-01
End date: 2011-10-31
Duration (months): 24.0
Total project cost (EUR): 250977.0
EU funding (EUR): 183908.0
Participants: 2
Project status: CLOSED

The ASE-TB project will design, manufacture and tune an innovative and smart Test Bench for linear actuators that will be capable of conducting synchronized tests on two linear actuators of the same type while applying different loads on them. The test bench will also include a thermal chamber for conducting tests at regulated temperatures with one of the actuators. This actuator test bench will be based on a modular, eco-efficient and adaptive concept by integrating easily exchangeable hydraulic and mechanical components with sensors and control strategies that will allow automatic and autonomous safety controls as well as energy saving approaches that will assure optimised lifecycle costs and environmental impacts during endurance tests. This innovative concept of actuator test bench will mean thus a positive impact on the safety and working conditions of the end users of the Test Bench as well as a reduction in the time and costs associated to testing linear actuators together with an increase in the quality and reliability of said tests.

Keywords: test bench,linear actuators,thermal chamber,safety control
Active flow control application on trailing edge flap for high-lift configuration (AFC-TEFL-HLC)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Germany
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2010-01-01
End date: 2012-09-30
Duration (months): 33.0
Total project cost (EUR): 299990.0
EU funding (EUR): 224993.0
Participants: 1
Project status: CLOSED

Trailing edge flaps in high-lift configuration are prone to turbulent flow separation on the suction side, which leads to a drop in lift and an enormous increase of drag. Active flow control (AFC) is an appropriate instrument for avoiding flow separating and therefore enhancing aerodynamic performance depending on the desired application. The superior goal of the Smart Fixed Wing Aircraft (SFWA) project is to prepare a large-scale wind tunnel (w/t) test with AFC applications on a trailing edge device in order to close the gap between mid-scale w/t testing and applications on aircraft level. The main task of this particular project mentioned in the call for proposal (CfP) is focused on developing an actuator system based on pulsed pressurized and / or piezoelectric flow control technique for delaying separation onset on trailing edge (TE) device. Moreover, a sensor system and a signal processing unit have to be developed to detect flow separation in order to close the control loop. Accordingly, the synthesis of a robust controller has to be addressed so that this system works transiently in all possible situations including scenarios with external disturbances. Subsequently this closed loop (CL-) AFC technique has to be investigated in a mid-scale w/t test arrangement at higher Reynolds numbers and including the swept case for more realistic flow field which is requested in the CfP of this particular project. The experience and data which will be achieved within this project will be the base for large scale w/t tests regarding AFC planned for the future. Technische Universität Berlin was and nowadays is involved successfully in national and European projects, such as SFB, M-Fly or AVERT, dealing with AFC. Hence TUB has a large background in AFC on high lift devices with experiences of more than 10 years and is a very appropriate partner for realizing the goals of SFWA project and meeting the vision 2020.

Keywords: experiments,high-lift aerodynamic,active flow control,closed-loop,trailing edge flap
Simulation of weather phenomena (SIMET)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain,France,France,Netherlands
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2010-01-01
End date: 2011-12-31
Duration (months): 24.0
Total project cost (EUR): 599831.0
EU funding (EUR): 449873.0
Participants: 4
Project status: CLOSED

Development of an innovative atmosphere &amp; weather phenomena repository and planning system able to feed a simulator in order to perform mission trajectories simulation and environmental impact assessments.

Keywords: weather,atmospheric,forecast,wind,clean sky,simulation,weather data repository,weather planning system,flight plan,trajectories,environmental impact.
Development and Manufacture Scoop Intake and Channel incl. ice and debris protection and acoustic absorbers (SIPAL)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom,United Kingdom
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2010-01-01
End date: 2011-03-31
Duration (months): 15.0
Total project cost (EUR): 498042.0
EU funding (EUR): 266091.0
Participants: 2
Project status: CLOSED

B.1.1 Concept and Objectives The concept of this project is to design and build a composite prototype scoop intake, incorporating the following key aspects of design • Acoustic panelling • Electro thermal ice protection • Lightning protection (if necessary) • Erosion protection • Temperature sensing The objective of the consortium team is to effectively trade the various design requirements to produce an optimised system solution. B.1.2 Progress beyond State of Art The project will investigate the integration both structurally and electrically of electro-thermal ice protection and acoustic absorbing panelling within a composite inlet scoop structure. It is not the purpose of this project to directly combine the ice protection and noise abatement technologies within the same area of scoop structure. A fully integrated, combined solution such as that is not viable within this project under the current budget; However, GKN does view this as an appropriate objective and a potential development area for future projects. By enabling this direct integration GKN expects significant noise reduction benefits. GKN sees potential in this entire application development area for offering technology progression. Work in this area to date has been focused on engine nacelle lip liner technology and has progressed well although additional support in this area would be necessary to continue the advancement.

Keywords: scoop,intake,acoustic,absorbers,ice protection
Advanced Turbofan-Equipped Aircraft Noise Model (FLIGHT-NOISE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2010-01-01
End date: 2012-08-31
Duration (months): 32.0
Total project cost (EUR): 329924.4
EU funding (EUR): 247443.0
Participants: 1
Project status: CLOSED

The aim of this project is to adapt, improve validate and test a computer model for the simulation of aircraft noise. The project starts from a well-established basis of a multi-disciplinany computer model that includes flight mechanics, aerodynamics, gas turbine engine performance, numerical modelling, optimisation, aircraft operations, and aircraft noise. The latter discipline also includes wave propagation and diffusion. The goals are: 1.) To produce a state-of-the-art noise and emission software. 2.) To validate and test the software with agreed benchmark cases. 3.) To provide training on the software and on aircraft noise. 4.) To provide technical support beyond the duration of the project. The work programme includes the following main tasks: 1.) Review of requirements and systems compatibility. 2.) Software upgrades in a number of key areas of propulsion and airframe noise. 3.) Generation of databases (airplanes, turbofan engines and topographical information). 4.) Validation and Testing. 5.) Documentation, Training and Technical Support.

Keywords: aircraft noise,propulsion,gas turbine engines,aerodynamics,flight mechanics