Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A novel concentrated solar steam system for industrial applications with a high degree of pre-manufacturing at extremely low prices. (helioSTEAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Austria
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Fresnex GmbH has developed a cheap and easy-to-install solar mirror system that concentrates the solar radiation onto a receiver, generating steam directly in the receiver. The steam is used in existing industrial steam systems for production in various industry segments. The technology works as a fuel saver technology by reducing energy costs, dependency on oil and gas and CO2 emission of its customers. Through a patented innovation Fresnex GmbH will be able to significantly reduce the system costs compared to existing technologies while parallel reducing the complexity of integration. Due to the lower investment costs, projects are now financial attractive, opening up a huge market. In Portugal, Spain, Italy and Austria together about 5,5 TWh could be switched to solar with even more potential in South Africa, Mexico, US, and many other countries. The innovation itself relates to a new and cheap mirror bearing, pivotable holding the mirrors. It is realised through a line-hinge in a cheap, effective and precise way. The thermal performance of the system prototype has been proved by a solar testing institute with good results. The management (two former university colleagues with 14 years of track record in plant engineering and construction) are the majority owners of Fresnex GmbH and they plan to sell company shares to further fund the project in addition to the already inserted private equity. In order to better understand the market needs and to gain customer contacts, Fresnex will perform a customer survey and address technical and financial topics as H2020 phase one project. The commercialisation plan includes a first system in industrial environment in 2015 (TRL5 to 6) followed by two reference systems for large scale implementations. At the same time the semi-automated production line will be developed. Without at least parts of this semi-automated production line, the two reference plants cannot be built (phase 2 project).

Keywords: the fuel saver technology will allow customers to reduce fossil fuel costs of existing steam boilers and significantly reduce co2 emissions the system is well suited for roof top applications
Which Architecture Yields Two Other Generations Of Fully depleted Advanced Substrate and Technologies (WAYTOGO FAST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Spain,Austria,Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Israel,Austria,Germany,Germany,Belgium,Finland,Greece,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: ECSEL Key Applications and Essential Technologies (IA) (ECSEL-2014-2, 2014)
Start date: 2015-05-01
End date: 2017-12-31
Duration (months): 32.0
Total project cost (EUR): 99399264.13
EU funding (EUR): 25796579.34
Participants: 34
Project status: CLOSED

The proposed pilot line project WAYTOGO FAST objective is to leverage Europe leadership in Fully Depleted Silicon on Insulator technology (FDSOI) so as to compete in leading edge technology at node 14nm and beyond preparing as well the following node transistor architecture. Europe is at the root of this breakthrough technology in More Moore law. The project aims at establishing a distributed pilot line between 2 companies: - Soitec for the fabrication of advanced engineered substrates (UTBB: Ultra Thin Body and BOx (buried oxide)) without and with strained silicon top film. - STMicroelectronics for the development and industrialization of state of the art FDSOI technology platform at 14nm and beyond with an industry competitive Power-Performance-Area-Cost (PPAC) trade-off. The project represents the first phase of a 2 phase program aiming at establishing a 10nm FDSOI technology for 2018-19. A strong added value network is created across this project to enhance a competitive European value chain on a European breakthrough and prepare next big wave of electronic devices. The consortium gathers a large group of partners: academics/institutes, equipment and substrate providers, semiconductor companies, a foundry, EDA providers, IP providers, fabless design houses, and a system manufacturer. E&M will contribute to the objective of installing a pilot line capable of manufacturing both advanced SOI substrates and FDSOI CMOS integrated circuits at 14nm and beyond. Design houses and electronics system manufacturer will provide demonstrator and enabling IP, to spread the FDSOI technology and establish it as a standard in term of leading edge energy efficient CMOS technology for a wide range of applications battery operated (consumer , healthcare, Internet of things) or not. Close collaboration between the design activities and the technology definition will tailor the PPAC trade-off of the next generation of technology to the applications needs.

Keywords: digital cmos technology,14nm node,fdsoi,advanced soi substrate,strain soi substrate
A new vantage point on how gas flows regulate the build-up of galaxies in the early universe (FEEDGALAXIES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1499557.0
EU funding (EUR): 907032.19
Participants: 2
Project status: SIGNED

Galaxies reside within a web of gas that feeds the formation of new stars. Following star formation, galaxies eject some of their gas reservoir back into this cosmic web. This proposal addresses the fundamental questions of how these inflows and outflows regulate the evolution of galaxies. My research team will tackle two key problems: 1) how gas accretion regulates the build-up of galaxies; 2) how efficiently outflows are in removing gas from star-forming regions. To characterise these flows across five billion years of cosmic history, we will pursue cutting-edge research on the halo gas, which is the material around the central galaxies, within dark matter halos. We will focus on scales ranging from a few kiloparsecs, where outflows originate, up to hundreds of kiloparsecs from galaxies, where inflows and outflows have visible impacts on halos. We will attack this problem using both simulations and observations with the largest telescopes on the ground and in space. With novel applications of absorption spectroscopy, we will gain a new vantage point on the astrophysics of these gas flows. Exploiting unprecedented datasets that I am currently assembling thanks to ground-breaking developments in instrumentation, we will directly connect the properties of halo gas to those of the central galaxies, investigating the impact that the baryonic processes probed in absorption have on galaxies seen in emission. In parallel, using new hydrodynamic simulations and radiative transfer calculations, we will go beyond present state-of-the-art methodologies to unveil the theory behind the origin of these gas flows, a crucial aspect to decode the physics probed by our observations. As a result of this powerful synergy between observations and simulations, this programme will provide the most advanced analysis of the impact that inflows and outflows have on galaxy evolution, shaping the direction of future work at 40m telescopes and the next generation of cosmological simulations.

Keywords: halo gas,inflows,outflows,absorption line systems
Targeting drug resistance in ovarian cancer through large-scale drug-response profiling in physiologically relevant cancer organoids (RESIST3D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Ovarian cancer is the fifth most deadly cancer type among women in Europe. Despite the fact that standard chemotherapy is usually effective in eliminating bulk tumour mass, thereby inducing remission, most patients diagnosed with advanced ovarian cancer die from the disease, as relapsed lesions emerge from small subpopulations of surviving drug-resistant cells. Precision medicine aims to improve cancer care through tailoring individualized therapies based on genomic or functional profiling of human cancers. However, as these approaches are usually performed on bulk tumour cells, the small pre-existing drug-resistant cell subpopulations remain untargeted. In the RESIST3D project, I will utilize ovarian cancer organoids – a patient-derived, three-dimensional cell cultures – to search for new strategies to eradicate drug-resistant cancer cells. I will use two organoid models developed for the same patient – one model derived from tumour material taken before chemotherapeutic treatment and one from a post-treatment sample, typically enriched in drug-resistant cells. I will further enrich the organoids in quiescent, drug-resistant cells by maintaining them in physiologic-like culture medium. I will then apply the models for drug-response profiling in order to identify agents that eradicate pre-existing drug-resistant cells, which could be combined with standard chemotherapy. Finally, I will assess whether the selected combinations prevent relapses in patient-derived xenograft mouse models. RESIST3D sets a new direction in precision cancer medicine, as it focuses on targeting small pre-existing subpopulations of drug-resistant cells rather than bulk tumour mass. Through combining organoid model, paired samples for each patient and physiologic culture conditions, I expect to identify new ways to target drug-resistant ovarian cancer cells. Moreover, RESIST3D will provide me with new research expertise and a scientific network that will enhance my research career.

Keywords: organoids,3d cell culture,drug resistance,ovarian cancer,precision cancer medicine,high throughput drug screening,drug response profiling,functional cell based assays,cell culture conditions
Unmasking insulin resistance triggering mechanisms using microphysiological two-organ systems as in vitro disease models of metabolic syndrome and non-alcoholic fatty liver disease (LIV-AD-ON-CHIP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-07-01
End date: 2023-09-26
Duration (months): 24.0
Total project cost (EUR): 162806.41
EU funding (EUR): 162806.4
Participants: 2
Project status: SIGNED

Insulin resistance is one of the key factors for non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome development and progression. Both diseases have an immense societal and economic impact. However, the biological mechanisms triggering the onset of the diseases are still poorly understood. NAFLD is assumed to be triggered by hepatic insulin resistance, possibly resulting from adipose tissue lipolysis dysregulation. The study of the crosstalk between liver and adipose tissue is thus essential for the understanding of insulin resistance triggering events but is limited by the availability of suitable models. Hence, the aim of this proposal is to establish a two-organ-on-a-chip-model and to utilize it to study liver-adipose tissue crosstalk and understand how hepatic and adipocyte insulin resistance develop and influence each other. In order to study the molecular mechanisms of inter-tissue communication and overcome the complexity and non-human nature of animal models, an innovative organ-on-a-chip system using a flexible connection technology will be utilized to culture hepatocytes and adipocytes in connected systems. Human stem cell derived adipocyte- and hepatocytes-like cells with the same genetic background will be cultured in this system and characterized regarding their metabolic competence. The cell’s functional characterization, transcriptomic and metabolomic analysis, upon pharmacological induction of insulin resistance, will allow to unravel its molecular triggering mechanisms in vitro. The same approach will be applied to patient-specific cells creating a patient-specific physiopatological in vitro model under distinct nutrient mixtures. This project is a highly innovative multidisciplinary approach that uses organ-on-a-chip technology for in vitro disease modeling to study the triggering molecular mechanisms and possibly identify potential biomarkers and/or pharmacological and non-pharmacological targets of high impact diseases.

Keywords: organ on a chip,insulin resistance,non alcoholic fatty liver disease,liver adipose crosstalk,bioenergetic metabolism,human stem cell differentiation,adipocyte like cells,hepatocyte like cells
Urban PoLicy Innovation to address inequality with and for Future generaTions (UPLIFT)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Estonia,Spain,Germany,Germany,Romania,Sweden,Hungary,Romania,Netherlands,Netherlands,United Kingdom,Portugal
Call: Innovative solutions for inclusive and sustainable urban environments (H2020-SC6-TRANSFORMATIONS-2019, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 2998500.0
EU funding (EUR): 2998500.0
Participants: 17
Project status: SIGNED

UPLIFT seeks to establish an innovative approach to urban policy design for reducing socio-economic inequalities. It acknowledges that policies aiming to reduce inequalities are often ineffective, as they do not respond properly to the strategies and behaviours of vulnerable households. At the same time, policy failure in the face of increasing socio-economic polarisation, especially in the post-crisis period and under the fourth industrial revolution, could further destabilise social cohesion and resilience. To address this challenge, UPLIFT aims to develop a Reflexive Policy Agenda through participatory co-creation: with the inclusion of vulnerable policy beneficiaries, the project will yield context-specific, flexible, adaptable policies, with appropriate feedback mechanisms. UPLIFT follows a multi-layer research method to map the processes and drivers of urban inequality in the post-crisis context. It uses macro level findings to contextualise micro level outcomes. It analyses the scale and dimensions of inequality in the EU, focusing on the national and regional (NUTS 2) scale. It then narrows down to sixteen functional urban areas (representing four robust urban types), looking at local inequality dimensions and drivers, and interpreting policy responses. On the third level the research narrows again to eight case studies, where micro-level analyses of vulnerability are carried out through the lens of youth (aged 15-29). Finally, in four Implementation sites UPLIFT co-creates reflexive policies with local stakeholders and communities, putting vulnerable youth in the centre from an educational, housing, or employment perspective. This focus on youth is not only a research tool, but is strongly justified by recent economic and policy shifts, which have put them most at risk of poverty and vulnerability in Europe. Additionally inequality at an early age tends to increase over the life cycle of the age cohort, necessitating early interventions.

Keywords: reflexive policy agenda,vulnerable youth,generational divide,policy co creation,participatory planning,urban inequality,household strategies,capability approach,multi layer research
Revisiting the Seventeenth-Century Republic of Letters (REVERE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Despite the important research available on early modern literary production and patronage by women, chiefly concerning the religious, the view of the marginality of the woman author ('author' understood then as one who wrote de suo and for publication) continues to be pervasive. My project will examine the role of gender in the construction of scholarly and commercial authorship in Spanish and English by elucidating the transnational nature of authorial and editorial practices with print during the commercialization of the literary product in the seventeenth century, thus making an original contribution to book history and gender studies. Extending the investigation of women’s literary careers beyond religion and across geo-linguistic boundaries is imperative, if we want an informed picture of the extent and implications of the mobility of print culture in this period. The awareness of the scarcity of international explorations of the cross-cultural mobility of women’s texts has encouraged some scholars to undertake transnational research in the field, but these studies are still a small minority, and their ambitions never concretely investigate how authorial and editorial practices interact with each other. For the most part, specialists continue to structure their arguments according to theme, period, geography, or language, thereby obscuring broader diachronic trends towards women’s increasing participation in the professional world of authorship. My study will interact with the ongoing MINECO-funded project, ‘Poder, espiritualidad y género (Castilla, 1400-1550): La emergencia de la autoridad femenina en la corte y el convento’, running at UPF (https://www.upf.edu/en/web/poder-espiritualidad-genero). Investigating the intercultural impact of women’s position as authors through print is in line with the primary objectives of this MINECO project, namely to enhance our knowledge of women’s authority within the court and in the convent in early modern Spain.

Keywords: authorship,print,publication,scholars,commercial authors,spanish,english,gender,transnational
Combining Tectonics and Machine Learning to Constrain Plate Reconstruction Models Through Time (TEMPO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-25
End date: 2021-08-24
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Plate tectonics processes continuously destroy oceanic crust, which contain the most reliable record of plate motion. There is therefore little data to constrain net rotation of the lithosphere with respect to the deep mantle, constraints on which are required to produce accurate reference frames for plate motion, The location of intra-oceanic plate boundaries and bathymetry in the geological past are also lost. I will use state-of-the-art numerical convection simulations combined with state-of-the-art machine learning techniques to put constraints on both net rotation and the location of plate boundaries with uncertainty estimates. This is possible due to the self-organising and statistically predictable nature of plate tectonics. I will develop one set of neural networks to make inferences for net rotation with uncertainties given observation of continent positions and movement. The networks will take both synthetic and real geological observations as training inputs and produce estimates for net rotation. They will be thoroughly tested using synthetic data and benchmarked using present-day Earth data, thereby testing both the networks and the physics behind the convection simulations. The networks will then be applied to the geological past. A second set of networks will treat the lack of information on oceanic plate boundaries as an image completion problem to fill the gaps in geological data. They will be trained to produce proposals for the location and type of oceanic plate boundaries that are consistent with the physics behind tectonic motion and mantle convection. The networks learn about the physics from the database of convection simulations. These proposals can be assessed against geological and palaeo-oceanographic data, provide suggestions for alternative solutions, give an indication of uncertainties and guide future data collection and modelling work.

Keywords: plate tectonic reconstruction,mantle dynamics,geodynamics,oceanic plate boundaries,machine learning,palaeogeography