Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Digital Data Generation and Streaming in the Big Data area: Exploiting the New Value Creation Opportunities in the 2020 Digital Enterprise (DDGS - VDE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-07-21
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The changing business ecosystem and the major transformations that organizations are experiencing today have a common denominator: Information and Communication Technologies (ICT). ICT are pervasive and ubiquitous and all business or social activities are now generating a corresponding digital data event. We call this ubiquitous and massive creation of real time data in a natively digital form Digital Data Genesis (DDG). These generated data could be made readably available or streamed (for example as open API – Application Programming Interface) to other partners, or appropriately transformed in customers’ value added services. This concept is what we define Digital Data Streaming (DDS). The relevance of these phenomenons are well depicted by the so called “big data challenge” where ICT management practices and IT architectures have to be redefined by firms to properly extract value. We argue that this scenario is disruptive compared to the past and challenge current business practices. Companies are now able to leverage vast amount of real time data to create new services, to increase service quality, and to gain new level of efficiency, but few research on this topic has been conducted until now. Using quantitative and qualitative data methodologies, we aim at: 1) develop a taxonomy of the initiatives taken by firms related to the DDG and DDS phenomena in order to understand the different models for value creation, based on digital data streaming, that firms follow; 2) investigate the typologies of “DDG/DDS Capabilities” developed by firms; 3) develop and test an index to assess the capacity of organizations to deal with real-time data initiatives; 4) identify whether companies that develop DDG/DDS capabilities economically perform better than the others. Managerial implications and contributions to the European research will be discussed.

Keywords: firms,competitiveness,innovation,digital data genesis capability,digital data streaming
Advanced Tools to Observe Magnetic and dynamical properties of Skyrmions and vortices down to the atomic scale (ATOMS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Two decades after the giant magnetoresistance (GMR) discovery, spintronics research area has quickly led to significant progress in the field of magnetic storage. Now, a new challenge for this discipline is the implementation of new nano-radiofrequency devices liable to revolutionize telecommunication technologies. Developments of such devices require the implementation of new and highly specialized characterization tools combining a high spatial and temporal resolution in order to study the local dynamical properties of nanoscopic magnetic objects relevant for this issue. Within this context, we propose to implement two innovative local probe experimental techniques able to probe the dynamical properties of magnetic structures in the radiofrequency range down to the atomic scale. One of these techniques will combine a radiofrequency excitation and detection with a spin polarized scanning tunneling microscope and will allow to perform local ferromagnetic resonance measurements. This technique is called ferromagnetic resonance scanning tunneling microscope (FMR-STM). The second technique we propose to use is called the time resolved spin polarized scanning tunneling microscope (TR-SPSTM). This technique combines a spin polarized scanning tunneling microscope with a pump probe electronic that allows to perform time resolved measurements. The magnetic objects we propose to study with these two experimental techniques are vortices and skyrmions, two structures particularly relevant for future low-power spintronics devices.

Keywords: magnetic vortex,skyrmion,dynamics,spintronics,spin-polarized scanning tunneling microscopy,pump-probe,spin diode effect
Ordered Algebraic Structures in Game Theory (OASIG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-11-01
End date: 2016-10-31
Duration (months): 24.0
Total project cost (EUR): 241567.6
EU funding (EUR): 241567.6
Participants: 1
Project status: CLOSED

The main goal of this project is to study ordered algebraic structures with regard to their applications in game theory. Theory of Riesz spaces, groups, and MV-algebras provide the tools necessary for modeling important aspects of mathematical games, such as economic rationality, strategic invariance, or fairness. This is already witnessed by many parts of game theory: for example, Aumann-Shapley value is a positive equivariant linear operator into the Riesz space of measures and MV-algebras model many coalition games. Our objective is to employ the methods, which were developed for solving deep algebraic and logical problems, in several important game-theoretic problems. Specifically, we will study the class of piecewise linear continuous strategic games by using the polyhedral representation of free MV-algebras and Baker-Beynon duality for unital free vector lattices, with the goal to show the existence of finitely-supported mixed strategy equilibria. We will investigate MV-algebras and their measures in order to model coalition games and their solutions. The motivation is to generalize the Danilov-Koshevoy representation of core by the convex Minkowski combination of simplices for larger classes of games. This inevitably leads to building dual representations of games based on the notion of generalized Moebius transform and the space of filters of an MV-algebra. Each facet of this project is transdisciplinary: the emphasis on algebra and order pervades all the selected game-theoretic scenaria. The presented proposal is an opportunity for the applicant to acquire new mathematical skills under the guidance of a scientist in charge - the specialist in ordered algebraic structures - and achieve thus a unique position in his own research field (game theory, many-valued logics).

Keywords: mv-algebra,ordered group,piecewise linear function,coalition game,strategic game,nash equilibrium,core,value operator,moebius transform,lukasiewicz logic
Thermostable transaminases for the synthesis of pharmaceutical building blocks (HOTRAM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 221154.6
EU funding (EUR): 221154.6
Participants: 1
Project status: CLOSED

Biocatalysis is considered a key component for the development of a sustainable chemistry in Europe by the European Commission, CEFIC and Biotech Industries Association. Indeed, the use of enzymes as biocatalysts in the chemical and pharmaceutical industries has been constantly growing in the last years. Aim of this project is to screen and obtain novel thermostable omega-Transaminases (TAs) from the metagenomes of (hyper)thermophiles. Furthermore, the novel TAs will be characterized and their biocatalytical application will be investigated. TAs catalyze enantioselective reductive amination reactions of ketones and represent an attractive option for the synthesis of chiral amines, valuable building blocks for the synthesis of several pharmaceutical compounds. In the respect of other enzyme classes, the array of available TAs is still very restricted. The search of novel TAs will provide suitable biocatalysts for the industrial development of a larger set of synthetic processes. The overall concept of this project is to exploit metagenomics for the discovery of a new generation of thermostable TAs from the hot terrestrial environments. The complementarity of the skills provided by the Applicant and the Host will ensure the success of the project. In fact, the Host is an expert in metagenomic studies and has already an in-house collection of environmental samples from various geothermal regions of the world available for library preparation. On the other side, the Applicant has a 7-years proved experience in applied biocatalysis, acquired by joining the Biocatalysis group at ICRM-CNR (Milan, Italy), one of the world leading research groups in the field. This experience will be exploited for the characterization and development of the novel biocatalysts. It must be pointed out that the project will have a strong impact on the applicant's career. In fact, the skills acquired during this experience will enhance her possibility to achieve a permanent position at ICRM-CNR

Keywords: biocatalysis,metagenomics,chiral amines,enzyme screening
Remarkable Preservation of Precambrian Organic Material (REPOM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-11-24
End date: 2016-11-23
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

Determining what is and what is not life in Earth’s oldest rocks, and identifying what type of life was present in these environments are fundamental scientific problems. Resolving these questions is vital in order to understand the origin of life on Earth, the role biology played in shaping early Earth environments, the nature and timing of evolutionary transitions, and to evaluate potential extra-terrestrial life. The timing and nature of the earliest life on Earth can only readily be addressed using fossil data, but these data are at present often the subject of controversy since they are difficult to interpret and there are few established criteria on which to interpret them. We effectively lack a coherent understanding of the evidence for the appearance of the major evolutionary grades of life on Earth. This proposal aims to remedy this and, in so doing, establish a gold standard for evaluating evidence of life on other planets. My overall objective is to develop and refine new ways of extracting information from remarkably preserved Precambrian organic material and the minerals that host it. This research will be focussed towards two aims: AIM 1 – provide new and more robust data to determine the authenticity of putative Precambrian life; AIM 2 – determine the type and diversity of life present in key Precambrian fossil assemblages. Specifically, this research will help to address some important outstanding questions in Precambrian paleobiology, including (i) evidence for the earliest cellular life, (ii) evidence for the nature of early diverse microfossil assemblages including the origin of eukaryotes, and (iii) evidence for the nature of early terrestrial biotas. More generally, the data generated will lead to a greater understanding of the origin and evolution of life, plus patterns of carbon preservation and burial through the Precambrian that influenced global biogeochemical cycles and climate change.

Keywords: paleontology,paleobiology,geochemistry,archean,proterozoic,microfossils,early life,astrobiology
E-H Bond Functionalization Using Group 14 Based Catalysts (OXRDSN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-06-02
End date: 2016-06-01
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The activation of relatively inert non-polar chemical bonds is key to numerous catalytic functionalization processes generating high value-added chemical products. In the region of 75% of all chemicals currently require catalysts at some stage in their manufacture, and typical catalysts feature heavier late Transition Metals, reflecting their amenability to bond modifying redox processes. Issues relating to the sustainable availability/cost of such elements and the incorporation of heavy metals into products, mean that the search for alternative catalytic platforms is at the cutting edge scientifically and economically. Main group metals, by contrast, are inexpensive, abundant, and in the cases of the lighter elements (such as the germanium compounds ultimately targeted here) less of an issue with regard to toxicity. The step change in homogenous catalysis which this proposal seeks to bring about is to open up catalytic bond modification processes based on redox chemistry (oxidative addition/reductive elimination) to Main Group metals. Our approach will be built on exciting preliminary results for tin systems, while ultimately targeting catalysts based around germanium, which is more environmentally benign, but a more challenging redox prospect. Our goals for the lifetime of this project are not so much to produce immediate replacements for existing Transition Metal systems in societally important catalytic transformations, but rather to establish the fundamental ground rules for catalyst design in what is an entirely new area of endeavour.

Keywords: main group system,group 14 tetrelenes,boryl and nhc ligands,redox process,hydrogenation of alkene,dual activation,binuclear system,hydroboration,hydrosilylation,c-h activation
MicroRNA targeting to achieve Systemic Sclerosis Control and Prediction (MICROSCAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 175974.6
EU funding (EUR): 175974.6
Participants: 1
Project status: CLOSED

Systemic Sclerosis (SSc) is a disfiguring disease with high mortality and morbidity, characterized by progressive and uncontrollable fibrosis of the skin and internal organs. There is no successful therapy for SSc resulting in a markedly shortened life expectancy, usually less that most cancers. Moreover, SSc diagnosis is very difficult in the early phase of the disease; consequently patient treatment is delayed until skin and/or internal organ involvement is evident and already irreversible. The pathology, therefore, presents an extreme need of both effective therapies and early diagnosis/prognosis markers, in order to treat SSc patients before the development of severe organ complications. The proposed project builds on the unique observation that plasmacytoid dendritic cells (pDC) are dysregulated in the early disease onset of SSc, due to an aberrant microRNA (miRNA) expression pattern. The aim of the proposal is to delineate the critical role of identified miRNAs in pDC dysregulation and translate it to clinical relevant instruments to prevent or treat SSc. Thanks to my scientific and technical expertise in the study of miRNAs and immune regulation, I will be able to dissect the aberrant mechanisms leading to pDC dysregulation via miRNA-regulated pathways. This will provide the basis to develop novel therapeutic approaches to dampen the immune alterations present in SSc and control the disease progression. Furthermore, the analysis of a unique cohort of preclinical SSc cohort present in Radstake’s group and its expertise in SSc field will allow me to identify miRNA profiles that predict the progression of early-SSc into definite SSc. The marriage between my own and Radstake’s group expertise will therefore create the perfect ground to open novel perspectives for a more effective treatment and prevention of SSc, reducing the disease impact on health and the economic resources employed for SSc patients, with an overall advantage for the entire European Community.

Keywords: systemic sclerosis,plasmacytoid dendritic cells,epigenetic,microrna,fibrosis,biomarkers,therapeutics
The role of Western lifestyle factors in smoke-induced inflammation in chronic obstructive pulmonary disease (IRESOLUTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 175974.6
EU funding (EUR): 175974.6
Participants: 1
Project status: CLOSED

Over the past century a substantial increase in the incidence of chronic inflammatory diseases has been observed in industrialized countries. This unexpected rise in diseases such as chronic obstructive pulmonary disease (COPD), asthma and inflammatory bowel disease has led to concern about how Western lifestyle may negatively influence our (anti-)inflammatory defense mechanisms. Inflammation is a process that needs to be actively terminated with help of anti-inflammatory and pro-resolving mediators. Several of these mediators are derived from molecules in our environment such as sunlight and nutrition. Accumulating evidence now suggests that Western lifestyle results in a lack of sufficient exposure to sunlight and insufficient intake of particular nutrients due to our diet, resulting in a reduced availability of essential anti-inflammatory and pro-resolving mediators in the body. The work described in this proposal aims to map the role of anti-inflammatory and pro-resolving mediators in smoke-induced inflammation in COPD. The outcomes of this study are expected to contribute to a better understanding of the resolution phase of inflammation and result in the identification of novel therapeutic targets that are applicable for COPD and possibly more inflammatory diseases. Obtaining new insights in the mechanisms underlying resolution of inflammation is of utmost importance to provide a foundation to curb the rise in inflammatory diseases.

Keywords: chronic inflammation,western lifestyle,copd,pro-resolving mediators,anti-inflammatory mediators,smoke
Bio-mechanical organisation of the modern human mandible in transition from foraging to agriculture. (BIOMAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2015-07-20
End date: 2017-07-19
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

It has been well over a century and a half since the evolution of our species was linked to developments in technology made by our immediate ancestors. However, do we actually know how these evolutionary changes in modern humans occur and how our own material culture drives our biological adaptation? This project will explore one of the most prominent examples of culture impacting on our anatomy from our recent history – the biological changes that human groups went through with the transition from foraging to an agriculturalist life style. It will test the hypothesis that alterations in diet brought about by changes in the mode of subsistence had a direct biological connection with the evolution of facial morphology among early agricultural populations via changes in mechanical forces acting on our mandible during mastication. Unlike any of the previous studies in the field, we will carry out tests on representatives of archaeological groups that were themselves involved in the process of developing and adapting to early agriculture. In so doing, we will be able to test whether and measure the extent to which modern humans have been affected by evolutionary processes imposed by our material culture, as is widely believed. The project will combine knowledge and techniques from a number of scientific fields: archaeology of pre-historic human populations, human biology, human evolution, bio-mechanics, Finite Element Analysis of material and shape properties and Geometric Morphometrics. We will use samples of human remains from archaeological contexts, which will include Upper Palaeolithic, Mesolithic, Neolithic and, in some cases, later human remains from three geographical locations: Russia and Ukraine, Romania and Israel. The host laboratory will provide for the state-of-the-art methodology and software required for this project’s success, whereas the candidate fellow will provide for the material access and will bring the knowledge on anthropology and archaeology

Keywords: transition to agriculture,hunter-gatherers,foragers,human mandible,bio-mechanics,geometric morphometrics,diet,adaptation,mode of subsistence,evolution