Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unveiling diurnal cycles in the Martian climate (MartianDiurnalCycles)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

The climate system of Mars shares similar fundamental properties and also substantial difference with the Earth’s system. Due to its small thickness with a surface pressure ~0.6% that of the Earth, the Martian atmosphere has significant and dramatic diurnal cycles driven by solar forcing. Atmospheric tides, clouds and dust are coupled, and they dominate the daily climate on Mars. However, the diurnal cycles in the Martian atmosphere are poorly understood due to the lack of data. Yet, the partial observations previously obtained could not be well reproduced by atmospheric models. Here I propose a comprehensive investigation of the diurnal cycles on Mars using recently obtained observations and state-of-the-art numerical simulations. I will work with Dr. Francois Forget at Laboratoire de Meteorologie Dynamique (LMD), taking advantages of the Mars General Circulation Model (GCM) developed and maintained in the host lab, and making the most collaborations with the science teams of two atmospheric sounders onboard Mars orbiters, TGO ACS/TIRVIM and EMM/EMIRS. Recent observations of the Martian atmosphere obtained by these two infrared spectrometers enable such diurnal cycle investigation for the first time thanks to their unprecedented spacecraft orbits. By combining the new data and the updated GCM, I will unveil and characterize the diurnal cycles in the Martian atmosphere, and understand the mechanisms in this coupled climate system. The results will have great scientific significance in understanding the climate of Mars, and have implications for future Mars mission planning. The proposal demonstrates the transfer of knowledge to the host institution LMD; the training of the candidate in research of Martian atmosphere and project management; and specific plans for dissemination and communication of the results. The project puts the candidate and host institution in good position to participate in future Mars missions, and reinforces the role of EU in Mars exploration.

Keywords: mars,diurnal cycles,atmospheric tides,clouds,dust,remote sensing,gcm
Mechanisms underlying functional disabilities in chronic musculoskeletal pain: the role of protective factors (PROTECT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: SIGNED

Chronic musculoskeletal pain is a major health issue, which translates into a severe economic burden. Studies on chronic pain conditions have focused primarily on characterizing pain mechanisms with a focus on alleviating clinical pain intensity. The success of these studies in terms of effective treatment remains extremely limited. Rather than focusing on pain intensity, PROTECT will focus on functional disabilities associated with chronic musculoskeletal pain, which are the main complain of patients. They can be extremely debilitating and often result in social isolation of persons with chronic musculoskeletal pain. To date, their mechanisms remain poorly understood. A better understanding of these mechanisms is essential to improve treatment efficiency. In work package (WP) 1 of PROTECT, the impact of athletic identity and mental and physical fatigue on the relationship between resilience and functional disabilities will be studied in adults and minors with chronic musculoskeletal pain (RO1). Resilience is associated with functional disabilities, athletic identity and fatigue, a frequent comorbidity of chronic musculoskeletal pain. Characterizing the complex relationship between these factors using computational modeling will define new treatment targets that can be addressed by adapting already available therapeutical interventions. All factors will be assessed using questionnaires, as well as physical and behavioral tasks. In WP2, resting-state fMRI will be used to assess brain networks of functional disabilities in adults with chronic musculoskeletal pain. In particular, the role of the Default Mode Network (DMN) in functional disabilities will be investigated (RO2). Changes in DMN connectivity have been associated with acute and chronic pain, as well as with resilience and athletic identity. Finally, PROTECT will focus on the potentially mediating role of resilience and athletic identity on the relationship between the DMN and functional disabilities (RO3).

Keywords: chronic musculoskeletal pain,resilience,fatigue,athletism,fmri,functional connectivity,default mode network,pain modulation
Exploring the dynamics of the gastrointestinal tract using shed cell and spatial transcriptomics (GI-DYNAMICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The gastrointestinal (GI) tract undergoes significant changes during post-natal development and in response to various diseases. Single-cell atlases are static and therefore fail to capture the dynamic changes occurring within the GI tract. We have devised a method to transcriptomically profile cells that are naturally shed into the GI tract. Contrary to earlier beliefs, we found that shed cells remain viable and can robustly be measured in fecal samples. Shed cell transcriptomics enables non-invasive tracking of cellular states throughout development and disease progression. Moreover, discrepancies between transcriptomic profiles of shed cells and tissues can identify which cell types are preferentially shed or retained, revealing cell turnover patterns. Our objective is to combine shed-cell and spatial transcriptomics to achieve basic and biomedical discoveries that were not possible before: 1. To study the developmental changes in the neonatal human GI tract. This will include longitudinal acquisition and in-depth analysis of shed cell transcriptomic and proteomic data in stool samples obtained from babies. 2. To characterize turnover of cells in colorectal cancer (CRC). We will combine shed cell transcriptomics in stool and blood with spatial transcriptomics of tumor biopsies to spatially map the cancer cells that resist death/shedding and examine their interactions within the tumor microenvironment. 3. To investigate cellular dynamics and tissue adaptations in Celiac disease. This will involve shed cell transcriptomics and high-resolution spatial transcriptomics to thoroughly understand the turnover rates of various enterocyte sub-populations and tissue adaptations during the disease. Our innovative use of shed cell transcriptomics will add a dynamic dimension to human cell atlas reconstruction efforts, enriching our understanding of tissue processes in health and disease.

Keywords: spatial transcriptomics,intestine development,cancer heterogeneity,celiac disease
Increasing responsiveness to citizen voice in social services across Europe (RESPONSIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Austria,Denmark,Poland,Portugal,France,Romania,Germany,Belgium
Call: The future of democracy and civic participation (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 3038596.0
EU funding (EUR): 3038596.0
Participants: 14
Project status: SIGNED

The RESPONSIVE project aims to enhance the responsiveness of Europe’s social services to input from diverse citizens. It wants to increase the impact of citizen voice on the approaches, organisation and delivery of three types of social service: disability and mental health, child protection and services for youth at risk. The project will help social services and EU policy structures to better understand, utilise and innovate with the knowledge, experiences and ideas of citizens through six core objectives: 1. Analyse the normative, legal, policy and practice contexts at local, national and EU level shaping how social services respond to the perspectives of diverse citizens 2. Assess the range, inclusivity, operation and impact of official channels of citizen input in social services (advisory groups, consultations, complaints, evaluation mechanisms) 3. Analyse the range, goals, content and approaches of public actions by citizens to change social services (protests, campaigns, social media, social enterprise, artistic production) 4. Identify the factors shaping changes by social services in response to the input of diverse citizens who use social services 5. Co-design and test tailored innovations for citizens, civil society groups, social services and policymakers to significantly expand the utilisation of different sources of citizen knowledge by social services at different levels 6. Promote uptake of innovations through dissemination of project results This qualitative research project will be conducted in Austria, Denmark, France, Poland, Portugal and Romania by an interdisciplinary and multisectoral consortium of six research organisations, two civil society organisations, two social services departments and an international network of social work practitioners.

Keywords: social services,dialogue,interaction
Quantum fields in and out of equilibrium via spinor Bose-Einstein condensates (QFIELBS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 2498250.0
EU funding (EUR): 2498250.0
Participants: 2
Project status: SIGNED

Our understanding of the physical world, from cosmological distances to subatomic scales, is based on field theories, with General Relativity and the Standard Model among the most validated descriptions of reality. Despite their history of success, the application of field theories, particularly in the quantum domain, is still characterized by a rich set of open questions related to processes in- and out-of-equilibrium. A paradigmatic example of a process in which field theories are successfully applied is that of first-order phase transitions. In this case, the dynamics of a system far from equilibrium cannot simply be described in terms of a perturbation of a steady state, but instead require combined tools and concepts taken from statistical and quantum mechanics. The transition results from the dynamics between field values associated with local minima of the system's energy. In the quantum regime, these local minima correspond to the so-called vacuum state of the field, making the problem well-defined but, surprisingly, exactly solvable in only a few simple cases. Relaxation dynamics between different vacua, commonly known as False Vacuum Decay (FVD), is a case study that has significant impacts in broad and interdisciplinary research areas. Models have been proposed to estimate the decay rate, entanglement generation at the beginning of the decay, the dynamics of decay products, and the generation of topological defects at the end of the relaxation process. However, our knowledge to date is limited by a substantial lack of experimental observations. This project aims to experimentally realize FVD and other challenging quantum field theories, both in the perturbative and in the non-perturbative regimes, such as confinement physics, using ultracold atomic spin mixtures through proper mapping of the atomic wave function into a quantum field representation and a unique set-up that ensures extremely stable magnetic field conditions.

Keywords: quantum simulation of field theories,out of equilibrium phenomena,quantum magnetism,coherently coupled atomic mixtures,analog models of gravity
Firm organization and the adoption of information and communication technologies (ORGANDICT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1486378.0
EU funding (EUR): 1486378.0
Participants: 2
Project status: SIGNED

The objective of my proposal is to push the frontier of our understanding of how the adoption of information and communication technologies (ICT) affects the internal organization of firms and thus firm productivity, employees’ careers and wages; how ICT adoption affects the organization of firms’ global value chains (GVC) and thus domestic employee outcomes; and how ICT adoption affects the foreign sourcing of innovation and thus domestic innovation. Existing research gives only partial answers to these questions as it provides limited insights into the economic mechanisms behind the effects of ICT adoption and the organization of GVC. Research is impeded by lack of data with exhaustive information on ICT, GVC, and firm and employee outcomes. My proposal will change that. I will assemble novel, comprehensive data sets with specific information on firms’ ICT use, GVC, balance sheets, and patents, as well as all employees’ characteristics, tasks, and wages. I will break new ground by developing theory and conducting theory-based empirical analyses that both identify causal effects and shed light on the economic mechanisms behind them. My proposal consists of three parts. Part 1 exploits unique features of my data to study how ICT adoption induces firms to reorganize employees. I will analyse changes to task complexity and autonomy, careers and wages within employees over time to explore complementarities between higher availability of information due to ICT and employee knowledge. Part 2 quantifies the effect of ICT adoption on offshoring, and, for the first time, studies how ICT adoption and offshoring jointly affect the task complexity and autonomy, careers and wages of employees, testing the predictions of task-based models. Part 3 evaluates the effect of ICT adoption on offshoring of research and development (R&D), a key determinant of growth, and derives and tests novel conditions under which foreign R&D complements or substitutes domestic innovation.

Keywords: ict adoption firm organization global value chains multinational firms employment wages tasks corporate innovation productivity
Making the Islamicate Bishop: Episcopal Governance and Networks under Islam (MASLAB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-05-01
End date: 2031-04-30
Duration (months): 60.0
Total project cost (EUR): 1492143.0
EU funding (EUR): 1492143.0
Participants: 1
Project status: SIGNED

By overcoming entrenched disciplinary divides and proposing a theoretical reframing, MASLAB explores how the social, religious and political changes of the Islamic period (mid. 7th-10th c.) fashioned episcopal governance, networks and power in the Christian communities of the Near East. Relying, for the first time, on a multi-language and multi-genre corpus, MASLAB looks at the actions that bishops took and the relations and resources they mobilized in handling new socio-political and religious circumstances: the legal codification of non-Muslims’ social status; the downgrading of Christianity from imperially sponsored religion to political minority; the crystallization of intra-Christian confessional boundaries; the more fluid and federalized notion of power and territoriality. This translates into three objectives: 1) Bringing together largely untapped material, and balancing qualitative and quantitative methods, it provides a prosopographic and topographic study of eastern Christian bishops and dioceses that has been lacking for decades. 2) It bridges disciplinary divides by executing unprecedented comparative studies on episcopal encounters with institutional power, interconfessional encounters and socio-spatial analysis of episcopal networks and governance, confronting four areas of specialism (Armenian, East Syrian, Syriac Orthodox, Coptic). 3) It articulates a novel account of episcopal leadership in the Islamic period, deconstructing the dominating communalist paradigm that sees non-Muslim groups as monolithic, state-recognized entities and reads episcopal relation with power only through the dyadic model ‘bishop-caliph’. Looking at the society in which bishops moved as a complex system of entangled elements, open to multiple internal and external impulses, MASLAB shifts emphasis from former binary paradigms to a multi-agent networks model and from a religious to a political interpretation that accounts for the socio-political variables of the Islamic rule.

Keywords: eastern christianity medieval near east christian muslim relations bishops
Transforming Mental Health Care with Neuroscience-Enhanced Virtual Reality (NEURO-VR24-BF-OCT25)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

NEURO-VR24-BF is an innovative project by Zest VR to revolutionize mental health treatment through immersive Virtual Reality (VR) therapies and AI-driven personalisation. Leveraging advanced Cognitive Behavioral Hypnosis (CBH), NEURO-VR24-BF offers faster, evidence-based solutions for conditions like PTSD, anxiety, and depression. The project combines groundbreaking neuroscience with cutting-edge VR technology and AI to create scalable and accessible mental health solutions. Supported by strategic partners like EY wavespace Rome, NEURO-VR24-BF aims to deploy its solutions across Europe, addressing a significant unmet need in mental health treatment while fostering societal wellbeing. With EIC’s Grant funding and, once our EU entity has been established, Blended Finance support, the project will scale from TRL 5-8 development to full-scale deployment (TRL 9), transforming existing mental health paradigms and opening new markets.

Keywords: therapy,mental health,anxiety,depression,ptsd,virtual reality,immersive,neuroscience,scalable,accessible,wellbeing
Mucosal IgM and IgD responses in fish: kinetics, interactions, and secondary/memory responses (MUCOFISH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-16
End date: 2027-06-15
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

The fastest-growing food production sector, aquaculture, faces important challenges because of infectious agents. Vaccination is the most effective way to prevent and potentially eradicate such diseases, but to date, most commercial vaccines are administered by injection methods, which for fish, imply many disadvantages. On the other hand, mucosal vaccines (directly administered to mucosal tissues) offer a promising and cost-effective alternative. In my MSCA project, I aspire to bring the field of mucosal immunology to the next level by applying my expertise in immune anatomy and working in the renowned laboratory of Prof. Carolina Tafalla who specializes in characterizing teleost B cells. Through this collaboration, I will uncover the cellular mechanisms and interactions of IgM and IgD B cells at fish mucosal sites, such as gills, skin, and intestines. In these tissues, plasma-like B cells secreting IgM coexist with IgD+IgM- B cells, cells that have lost surface IgM through an unclear recombination event. These cells secrete IgD, suggesting an important but undefined role for IgD at specific mucosal surfaces. At INIA, I will be trained in flow cytometry and single-cell transcriptomics. I will complement these techniques with my knowledge of immune anatomy to comprehensively unveil the role of these mucosal plasma-like cells upon immunization in rainbow trout. This project will innovatively expedite mucosal immunology research and underline my ambitions to become an independent scientist. I will further sharpen my scientist profile through CSIC’s mentoring programs for young researchers, which will enhance my skills in formulating and managing large-scale projects. I will also supervise students, keeping me engaged in the academic sector. The proposal addresses pressing scientific questions by integrating the expertise and network of both the host and me while shaping my path to becoming a senior scientist.

Keywords: mucosal vaccines,immunization,immunoglobulins,teleost b cells