Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular mechanisms underlying selective neuronal death in motor neuron diseases (Neurovulnerability)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany,Spain
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1472667.34
EU funding (EUR): 1472667.34
Participants: 2
Project status: SIGNED

The mechanisms behind neuronal death in different motor neuron diseases (MND) remain unknown. These MNDs include the devastating spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). A fascinating question in neurodegeneration research is why mutations in ubiquitously expressed genes result in the selective death of a specific neuronal subtype. The ubiquitously expressed and conserved survival of motor neuron (SMN) protein receives its name because its deficit results in MN degeneration. However, SMN known functions -spliceosome assembly and axonal mRNA transport- do not explain the selective MN vulnerability. Accumulation of intracellular aggregates in neurons is a hallmark of most neurodegenerative diseases. The lysosome-autophagy system is the main catabolic pathway for recycling of protein aggregates and damaged organelles, and its role as a quality control system is especially critical in neurons, due to their postmitotic and highly specialized nature. The hypothesis for this proposal is that SMN deficiency leads to a lysosome-autophagy dysfunction which results in a proteostatic failure, underlying MN degeneration. Furthermore, the existing heterogeneity in SMN protein levels across MN populations may determine their probability of survival. To test these hypotheses we will use the CRISPR/Cas9 system to genetically engineer human control, SMA and ALS patient-derived iPSCs to generate isogenic and reporter lines that will allow us to study selective neuronal subtypes at a single-cell level. We will also follow an interdisciplinary approach using a SMA Drosophila model to identify new molecular pathways essential for SMN neuropathology. Altogether, my research proposal aims at untangling the molecular mechanisms underlying selective MN death. Our results will open up new directions of research into the molecular basis of neurodegeneration and will provide clues for the design of therapeutics targeting specific neuronal types or phases of MNDs.

Keywords: motor neuron,ipscs,lysosome
Planetary Instruments based on Optical technologies for an iNnovative European Exploration Using Rotational Seismology (PIONEERS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,Belgium,France,France,France
Call: Scientific instrumentation and technologies enabling space science and exploration (H2020-SPACE-2018, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 3581701.25
EU funding (EUR): 3004356.3
Participants: 8
Project status: SIGNED

Planetary seismology is a key technique to image the internal structure of planetary objects, and target fundamental science objectives from the formation of planetary systems to the characterization of habitable worlds. With the SEIS instrument on board InSight mission, Europe has demonstrated its leadership in developing such instrumentation. PIONEERS will allow Europe to keep its technological advance and to enter a new realm of planetary exploration with an innovative ground motion instrumentation concept relying on high precision sensors based on optical interferometry, and on 6 degrees of freedom (6 DoF, with 3 translations and 3 rotations) measurements that provide substantial more science return compared to usual seismometers. The PIONEERS project will develop two 6 DoF instruments for measuring ground deformations of planetary objects. The first instrument is a very low noise 6-DoF engineering model dedicated to imaging the internal structure of terrestrial planets. The second one is a high TRL, reduced scale version of the same instrument dedicated to the exploration of small bodies, in order to support planetary defense and asteroid resources applications. We will build the instruments with the expertise in planetary seismology and high performance optical technologies provided by the PIONEERS partners. Innovative data analysis methods, as well as Earth analogue field testing will validate the expected increase of performance level by two orders of magnitude. Cost optimization, ITAR-free strategy and adaptation to CubeSat standards will drive other technological developments opening new markets for high precision scientific instrumentation. Instruments developed by our consortium members are demonstrating their predominance this year (SEIS on board InSight, blueSeis commercial rotational seismometer release, ROMY laser interferometer). It is therefore the right time to keep European leadership strong by innovating both on instrument concept and technology

Keywords: planetary interiors,seismology,ground deformations,rotational sensors,fiber optics,optical interferometry,asteroids,rotation of planetary objects,cubesat
Structural Dynamics of Membrane Receptors at native-like conditions (DYNAMO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Proteins embedded in cell membranes are vital signaling and trafficking platforms connecting the outside to the inside of a cell, and functioning as primary drug targets. DYNAMO is an integrative dynamic structural biology project, with the ambitious goal of developing and implementing comprehensive experimental and computational approaches for studying the structural dynamics of membrane receptors (MRs) and their complexes at native-like conditions. DYNAMO is highly interdisciplinary, combining protein chemistry and computational physics to study dynamical processes underlying the function of MRs, and is designed to combine the expertise of the fellow and host. The project will establish an integrated platform based on the nanodisc-technology and the combined use of low- and high-resolution structural biology techniques to bring unique and alternative insights into the structural dynamics of MRs containing ”fuzzy” (i.e highly flexible) domains, and the role this plays in functional signaling assemblies. In order to broaden the scope of the project and secure a general applicability of the developed methodology, full-length tissue Factor (TF) and Ghrelin receptor (GHS-R1a) are selected as models of single-pass and multi-pass MRs. These MRs do not only display different topologies and functional assemblies but also different selectivity towards lipids. TF and GHS-R1a are central to blood coagulation and energy homeostasis, respectively, and also connected to genetic and metabolic disorders, and thereby not only relevant as model systems but also promising drug targets. The project will exploit the recent advances in SAXS/SANS- and NMR-based methods to study the TF and GHS-R1a in nanodiscs, with an emphasis on their conformational ensemble nature. Upon the establishment of the methodology, it will be extended to study the interaction with their endogenous ligands.

Keywords: tissue factor,gpcrs,conformational dynamics,membrane mimics,nanodisc technology,integrative structural biology,biomolecular nmr,neutron and x ray scattering
Demonstration of dynamic grid stabilisation with an Adaptive-flywheel/battery Hybrid energy Storage system in Ireland and UK (AdD HyStor)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Germany,Ireland,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-03-01
End date: 2020-08-31
Duration (months): 42.0
Total project cost (EUR): 3909663.75
EU funding (EUR): 2944001.25
Participants: 4
Project status: CLOSED

Decarbonisation of the world’s energy system is needed to reduce CO2 emissions, ensure energy security and increase sustainability of the world’s natural resources. Renewable energy generation technologies such as solar PV and wind can be used a low carbon alternative. However, the use of these less predictable intermittent renewable technologies can lead to grid instability. As more renewables are connected to the system in line with EU legislation, this will become a critical problem throughout the EU. Grid scale energy storage technologies which can be used to store excess power for times of low generation can mitigate the problem, ensuring a balanced supply of power and utilisation the maximum renewable energy generation capacity. The project will leverage two existing energy storage pilot sites to demonstrate the performance of a European manufactured adaptive-flywheel on the Irish and UK transmission grids. During the project, Schwungrad Energie, Adaptive Balancing Power, University of Sheffield and Freqcon will develop an adaptive flywheel battery hybrid energy storage system for dynamic grid stabilisation for initial deployment within both test grid systems prior to EU commercialisation. The demonstration of its functionality in both grids increases the technology readiness level (TRL) of the adaptive flywheel battery hybrid energy storage system from TRL 6 to TRL 8, which allows commercial application and is a requirement for scaling up of the technology post project. As of 2020, similar dynamic grid stabilisation measures will be needed in the EU as well as in global grids in the medium term. This project gives the consortium a stable foundation to access the dynamic grid stabilisation market on a global scale. This will increase the revenue of all EU based SME’s involved in the project, allow the creation of IP and give a return on investment based on partner profit and EU project contribution of 1183% by 2025.

Keywords: flywheel,adaptive flywheel,energy storage,grid balancing
Ionic Solvent-based Recycling of Polypropylene Products (ISOPREP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Austria,Germany,Türkiye,Türkiye,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,United Kingdom
Call: Efficient recycling processes for plastic containing materials (IA) (H2020-NMBP-SPIRE-2018, 2018)
Start date: 2018-10-01
End date: 2022-09-30
Duration (months): 48.0
Total project cost (EUR): 6878363.75
EU funding (EUR): 6314631.140000001
Participants: 10
Project status: SIGNED

This project addresses the call topic CE-SPIRE -10-2018: Efficient recycling processes for plastics containing materials. A method (ISOPREP) is proposed for recycling polypropylene (PP) products into virgin quality PP and hence reusable for the production of the highest grade PP products. The method exploits a novel ionic polymer solvent designed for highly tuned solubility of PP, patented within the partnership, with the key advantages/innovations: (1) A performance identical to PP resin freshly manufactured from fossil sources (2) Cost effective compared with producing PP from fossil sources (3) Reduces the reliance of PP production on fossil resources (4) Achieves a step reduction on life cycle emissions and energy compared with the use of fossil resources (5) Is entirely closed loop with negligible loss of solvent per cycle and hence negligible emissions thus non-polluting (6) The solvent is non-toxic and non-flammable in the process temperature range (6) Removes dyes, colours and impurities (7) Prevents sending end of life PP products to landfill and avoids them polluting both land and sea PP is used in a huge variety of products such as automobile interiors, consumer goods packaging, electronics, construction materials, carpets and other home furnishings. The global PP market, accessible by the ISOPREP system, was estimated at €65bn per annum in 2017, totaling approximately 23% of the entire plastics market. Given the typically short life of PP products, only 1% of which are recycled, there is a great need to implement innovative and disruptive technologies to mediate this trend. Although applicable to a wide range of products, the concept will be developed and demonstrated at pilot plant stage for recycling polypropylene carpet at TRL7, based on prior and patented knowledge within the partnership at TRL5.

Keywords: ionic polymer solvents,polypropylene recycling,low emissions in recycling,low energy consumption in recycling,virgin polypropylene from non fossil sources,renewable plastics
Film Studios: Infrastructure, Culture, Innovation in Britain, France, Germany and Italy, 1930-60. (STUDIOTEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2498965.0
EU funding (EUR): 1678864.0
Participants: 3
Project status: SIGNED

This project investigates film studios across four major European production sites: Britain, France, Germany and Italy, 1930-60. During these years studios were transformed as they responded to challenges including wartime disruptions, post-war fragmentation, movement of labour and the introduction of new technologies. While these countries have attracted their own historical literatures, this project proposes for the first time their comparative analysis from the perspective of film studio tectonics, cultures and practices. The project is underpinned by the idea of tectonics as a metaphorical way into understanding the studios’ multiple, stratified, shifting experiences as architectural spaces, diverse working environments and locations for innovation. The study of film studios has been dominated by the centralized Hollywood ‘system’, and local studio histories are typified by discrete, linear and undertheorized approaches. This project proposes a more dynamic materialist methodology, linking empirical data with comparative, transnational developments which occurred during a major period of change within the four key production sites. Using historical research and a range of spatial analysis, 3D and VR tools, the project will explore studio spaces as diverse creative and economic infrastructures which both extended and challenged the range of contemporaneous models. The team will investigate how artistic practices responded to transnational flows in film studio expertise while constituting formative, materially-based ‘spaces of the imagination’. Research will be structured around four major interrelated themes: 1) Architecture and Infrastructure; 2) Creativity, Practices and Innovation; 3) Politics and Economics; 4) Professional and Labour relations. The project will create new understandings of how the collaborative and material environments of studio spaces and technologies shaped film production and cultures.

Keywords: film,studios,cultural production,europe,creativity,labour,transnational
Integrated Home Energy RenOvation Service (I-HEROS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,France,France,France
Call: Integrated home renovation services (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-09-01
End date: 2024-02-29
Duration (months): 42.0
Total project cost (EUR): 1499663.75
EU funding (EUR): 1499663.75
Participants: 8
Project status: SIGNED

The 3 years long I-HEROS projects aims at developing a fully integrated home renovation service in Toulouse Métropole, the 4th French city with an urban area of 1.3 M inhabitants. The project aims at enhancing cooperation and coordination between existing programs and initiatives while adding innovative elements such as a technical diagnostic tool developed specifically for the Toulouse Métropole housing stock. This will be achieved through a strong consortium relying on partners with in-field experience in the technical, digital, social, legal and administrative aspects of renovation, as well as through a strong support and implication of the local actors. The consortium will capitalize on a widespread regional and national coverage to ensure efficient dissemination of the results and upscaling. The partnership with a German partner ZEBAU, with extensive experience in EU dissemination, will initiate cooperation and replication on an intricate level with the city of Hamburg and Germany. Long term sustainability of the service will be ensured through the development of an attractive financial offer and a robust business plan developed by the consortium under the lead of the Caisse des dépôts et Consignations. To reach the ambitious objective of renovating 2000 homes per year after the project, a 2-year trial period will initiate 500 renovations per year. During this trial, KPIs tracking and an external evaluation will enable the monitoring of the service performances and its optimization to ensure both the quality and sustainability of the service, ultimately improving homeowners trust. It is expected that, 3 years after the end of the project, 70 M€ of investments in renovation will have been triggered with more than 500 homes saved from energy poverty situations while the whole service will support in excess of 1300 jobs. Three years after, 56 GWh/yr of primary energy will be saved and the reduction of GES emissions is estimated at 14 700 tCO2-eq/yr.

Keywords: renovation home service diagnostic energy efficiency house condos flats coordination support individual coproperties syndicates
Ultrafast dynamics of correlated electrons in solids (FASTCORR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Sweden,Sweden,Netherlands
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-06-01
End date: 2026-05-31
Duration (months): 72.0
Total project cost (EUR): 7746125.0
EU funding (EUR): 7746125.0
Participants: 4
Project status: SIGNED

Experimental activities at advanced photon sources, such as pulsed lasers, high harmonic generation facilities, and X-ray free electron lasers, generate results that challenge our understanding of light-matter interaction and ultrafast dynamics at the femtosecond and sub-femtosecond timescales. These results are particularly difficult to interpret for materials with correlated electrons, where a driving pulse can produce strong non-linear effects. In FASTCORR, we answer this challenge with the development of a theory for driven quantum many-body systems that goes well beyond existing methods. This will be accomplished by developing dynamical mean-field theory and its generalizations, e.g., the dual fermion and dual boson theory, to cover out-of-equilibrium phenomena. We aim to create a solid theoretical foundation on which we will build practical tools that allow to interpret and predict ultrafast time-resolved phenomena of correlated electron systems. This involves (i) the development of fundamental mathematical and physical concepts, (ii) software implementation, and (iii) numerical simulations that will be compared to experiments. Synergies between the three applicants are crucial to achieving the goals of this project. FASTCORR will result in novel high-performance software that we will distribute freely. These computational tools will enable designed and targeted calculations for driven materials where the electronic structure is determined by strong correlation effects. The developed theory will be used hand in hand with world-leading experimental works in the field of pump-probe measurements and spectroscopy, e.g., as investigated at X-ray free-electron laser laboratories.

Keywords: dynamic mean field theory,correlated electrons,ultra fast phenomena,spectroscopy
Structure and dynamics of glasses: using novel X-ray tools to push the boundaries of how we understand them (GlassX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-23
End date: 2023-08-22
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

Glasses are ubiquitous in our daily lives, yet the current understanding of them is very limited. Despite decades of research, the structure and dynamics of glasses and the nature of the glass transition remain open problems in condensed matter physics. To a large extent, this is due to the intrinsic properties of glasses: they lack long-range order, which makes it difficult to fully characterise their microscopic structures; they are out-of-equilibrium by nature, which leads to temporally evolving and spatially heterogeneous dynamics. With the advent of a new generation of X-ray sources and the development of novel X-ray technologies, these challenges can now be addressed. The GlassX action thus aims at exploiting these new opportunities to significantly better our understanding of glasses. The action is divided into four parts, each addressing an important open question in glass physics. Parts 1 and 2 focus on structural properties of vapor-deposited metallic glasses, including the degree of local anisotropy and the relation between their structure and stability. Parts 3 and 4 concentrate on the dynamics of glasses, including the wave-vector dependence and the existence of dynamic heterogeneities. These projects will make use of X-ray nano-diffraction and X-ray photon correlation spectroscopy techniques, both of which will see significant improvements with the newly available fourth-generation X-ray sources, making it possible to reach previously unexplored length and time scales. The knowledge generated by the action will contribute substantially to the field of glasses, both from the aspect of basic science and in terms of possible applications. Dissemination of the results will also be an integral part of the action, with the goal to effectively communicate the research outcome and its relevance to audiences both within and outside academia.

Keywords: metallic glasses,physical vapor deposition,x ray nano diffraction,x ray photon correlation spectroscopy,x ray free electron laser