Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeted Nano-Photomedicines for Multi-spectral Photodynamic Therapy of Cancer (NANO-PHOTOMED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-09-01
End date: 2009-08-31
Duration (months): 12.0
Total project cost (EUR): 83848.58
EU funding (EUR): 83848.58
Participants: 1
Project status: CLOSED

We propose to develop multifunctional, targeted nano-photomedicines that are capable of bypassing biological barriers to deliver nano-engineered photosensitizer drugs and molecular-imaging agents to tumor tissues and angiogenetic micro-vasculature. Specifically, a unique nanomedicine system for targeted multi-spectral photodynamic therapy is proposed. The system consists of (i) luminescent quantumdot (QD) conjugated with photosensitizer (PS) drugs, which can be sensitized at its maximum efficiency using radiations of deep-tissue penetration (ii) molecular-imaging agents for the early stage detection and in situ treatment-effect analysis (iii) active targeting ligands to specifically target tumor and micro-vasculature. During the incoming phase, QDs of ZnS, Y2O3 and Gd2O3 emitting multi-spectral light under excitation with deep high-tissue penetrating radiations will be conjugated with PS so as to sensitize them at their characteristic absorption using Fluorescent Resonant Energy Transfer (FRET). The QD-PS will be combined with MRI contrast agents using `core/shell’ nanotechnology and made water soluble by capping with polyethylene glycol (PEG). Finally, the nanomedicine will be connected with tumor specific ligands such as folic acid, MAbs and peptides. Optimization of nanomedicine will be carried out by studying dark and photo-toxicity in normal and cancer cell-lines in vitro. Photodynamic treatment will be carried out in pre-clinical animal models using multispectral radiations under different photo- and drug-dose conditions, followed by molecular imaging (MRI) based estimation of PDT response-dose inter-relationships. During the return phase, scanning probe imaging based investigations on the mechanism-of-activity of nano-photomedicines at intra-cellular regions leading to cell-death (apoptosis) will be investigated.

Keywords: health sciences,anticancer therapy,nanotechnology,nanomedicine,photodynamic therapy
Three years post-Tsunami: long-term effects of trauma in children aged 7-15 - a culture-sensitive approach (POSTTSUNAMI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-10-01
End date: 2011-09-30
Duration (months): 36.0
Total project cost (EUR): 148504.09
EU funding (EUR): 148504.09
Participants: 1
Project status: CLOSED

The Tsunami disaster ranks as the most severe natural disaster ever recorded in terms of the number of people who were directly affected. In the worst hit part of India, the Southern state Tamil Nadu, records show that 1,744 children under the age of 18 were orphaned and 1,450 lost one parent. Few studies exist which investigate the long-term effects of trauma on children's and caregivers' well-being in developing countries. The aim of this project is to assess the three years post-event mental health status of children and caregivers from this region. The project will use a beneficiary-oriented approach and will focus to culture- and gender-sensitive issues. Participatory research techniques, including adult as well as child key informants, will be used to identify indicators of children's and caregivers' well-being. Based on the developed indicators, interview guidelines for the caregivers will be formulated. Symptoms will be collected via questionnaires conducted in form of oral interviews using the following standards: The Child Behaviour Checklist (CBCL), the Children's Posttraumatic Stress Disorder Reaction Index (CPTSD-RI) and the Symptom Checklist-90-R (SCL-90-R). Tsunami-affected caregivers and children will be recruited from SOS Children's Village in Pondicherry and SOS Relief Programmes in Nagapatinam for whom specifically these interventions were set up. The psychosocial guidance, which will be developed upon the collected data, will focus to the strengthening of resilience. The guidance will be developed by following a procedural method and is therefore applicable to different cultures taking also gender issues into account. In particular, this guidance will develop a culture-sensitive measure for children's and caregivers' well-being in the aftermath of disasters and hence of great value also to Western cultures such as the EU countries due to the growing cultural diversity in European cities.

Keywords: applied psychology,third world studies,childhood trauma
Seismology of flaring coronal loops (FLARESEIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 169008.08
EU funding (EUR): 169008.08
Participants: 1
Project status: CLOSED

Magnetohydrodynamic (MHD) waves and oscillations, observed in astrophysical, laboratory and space plasmas provide us with an excellent tool for the remote diagnostics of the plasmas, which are, in particular, implemented in the techniques of solar coronal seismology, Earth’s magnetospheric magnetoseismology, and MHD spectroscopy of tokamaks. The identification of MHD modes in quasi-periodic pulsations (QPP) of the emission generated by solar and stellar flares opens up interesting perspectives for the study of fine structuring of the solar corona, as well as for the diagnostics of stellar coronae. The aim of the project is to advance our theoretical understanding of MHD modes of flaring plasma structures and the plasma emission modulation by these modes; to develop and implement plasma diagnostic techniques based upon those modes, to analyse QPP of the flare-generated microwave and X-ray emission and to identify the MHD modes associated with them. The detected QPPs will be exploited to do coronal seismology, i.e. by comparing the observations with the models, deducing physical parameters in the solar corona.

Keywords: physical sciences,astrophysics,solar corona,flares,coronal loops
Colloidal Liquid Crystals of Flexible Particles: Theory and Simulation (COLCFLEX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 170142.1
EU funding (EUR): 170142.1
Participants: 1
Project status: CLOSED

Statistical-mechanical theories will be developed and computer simulations carried out on model colloidal systems of semi-flexible rods and discs. The phase behaviour, structural and dynamical properties will be investigated as a function of the degree of internal particle flexibility. A more general virial theory for the isotropic-to-nematic phase transition in worm-like rods, which includes the third virial term in the excess free energy expression, will be formulated and worked out. This theory will be extended to inhomogeneous phases, such as smectic and columnar. The investigation of worm-like rod systems will serve as the basis for subsequent work on flexible, sheet-like particles, which constitutes the central research objective of the fellowship. The virial theory will be extended and applied to systems of flexible discs. For these, few results are available at present and it is not even known whether some degree of flexibility of the platelets will suppress the isotropic-nematic transition or not. The project seeks to settle this matter. The effect of the third virial term on the isotropic-to-nematic phase transition will be investigated. The stability of more ordered phases, such as the columnar phase, upon introducing and increasing internal particle flexibility, will be addressed. Concomitantly, for both rod-like and disc-like particle systems, computer simulations will be carried out and the results for phase behaviour compared with the theoretical predictions. Simulation will give also access to structural and dynamical properties of the phases involved. The topics addressed are of general importance in Soft Matter and the models considered mimic a wealth of experimental systems, such as rod-like virus particles, rod-like and disc-like clay particles, and bio-membranes, which are of current technological and biological importance.

Keywords: physical sciences,liquid crystals,colloids,statistical mechanics,computer simulation
Statistical Tools for studying genetic architecture (STSGA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-04-01
End date: 2009-12-31
Duration (months): 21.0
Total project cost (EUR): 189689.9
EU funding (EUR): 189689.9
Participants: 1
Project status: CLOSED

Molecular biology has shown that most phenotypes are affected by complex, interacting gene networks. Yet, evolutionary biologists and population geneticists often assume very simple genetic architectures where genes act more of less independently of each other. These assumptions are made for conceptual clarity and are partially justified through statistical definitions of gene effects that capture the main effects of alleles as averages over many complex interactions. Still, recent research has revealed many systematic patterns of epistasis and pleiotropy with population genetic effects that should not be ignored. This makes a detailed understanding of genetic architecture important for many questions in evolutionary biology, including the basis of evolvability, and also instrumental for many questions in animal and crop improvement, including our ability to predict selection limits and to avoid unwanted side effects of artificial selection. The philosophy of this project is to develop methods that yield operational measurements of dynamically relevant parameters. A serious problem is the study of genetic architecture has been that many of the parameters in use are not derived from process models, epistatic variance components being the most obvious example. For this reason, it is necessary to combine the statistical models with process models to ensure a general understanding of the meaning of estimators.

Keywords: biodiversity,population genetics,statistics,animal and plant breeding,quantitative genetics
Archaeal activity dynamics in marine snow vs. ambient water in coastal European Sea (ARCADIA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria,Netherlands
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-01-15
End date: 2011-01-14
Duration (months): 24.0
Total project cost (EUR): 157733.2
EU funding (EUR): 157733.2
Participants: 2
Project status: CLOSED

Our knowledge on the marine nitrogen cycle has undergone some major revisions very recently with the discovery of novel pathways mediated by thus far unknown and partly unculturable prokaryotes. Among these new drivers of the nitrogen cycle are non-thermophilic Crenarchaea and Euryarchaea. Recently, Crenarchaea have been shown to harbor the amoA gene, responsible for the expression of ammonia monooxygenase, which represents a key enzyme in the nitrification step. The project aims at determining the dynamics in abundance and activity of these Archaea in European coastal seas. Specific emphasis is paid to differentiate between the free-living, planktonic Archaea and those attached to the two major types of suspended particles in coastal areas, lithogenic vs biogenic particles. We will assess the phylogenetic composition of the free-living and particle-attached crenarchaeal and euryarchaeal communities and compare them with those of beta- and gammaproteobacterial communities as these two bacterial groups are also known to harbor nitrifying phylotypes. Conventional fingerprinting techniques using the 16 S rRNA gene and terminal-restriction fragment length polymorphism, cloning and sequencing will be combined with the pyro-sequencing approach, the latter allowing an unsurpassed resolution of the total number of phylotypes present. Quantitative PCR on the 16S rRNA level and on crenarchaeal and beta- and gammaproteobacterial amoA gene level will be used to determine the number of crenarchaea and bacteria putatively oxidizing ammonia. This approach will be combined with fluorescence in situ hybridization and autoradiography to allow insights into the microspatial distribution of Crenarchaea on suspended particles. These molecular approaches to determine the abundance and phylogeny of nitrifiers in ambient water and on suspended particles are complemented by nitrification rate measurements differentiating, for the first time, bacterial from crenarchaeal nitrification using

Keywords: bacteria,crenarchaea,nitrification,coastal sea,suspended particles,marine prokaryotes
Alcohol Measures for Public Health Research Alliance (AMPHORA) (AMPHORA)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Spain,Germany,Germany,Germany,Germany,Sweden,Switzerland,United Kingdom,Netherlands,United Kingdom,Netherlands,Italy,Austria,Poland,Slovenia,Norway,Netherlands,Hungary,United Kingdom,Finland,France,United Kingdom,Italy,Spain
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 4013243.6
EU funding (EUR): 2996687.0
Participants: 33
Project status: CLOSED

AMPHORA is a Europe wide project involving researches and research institutions from 14 European countries, and counterparts and organizations from all 27 Member States, that will provide new scientific evidence for the best public health measures to reduce the harm done by alcohol through addressing social and cultural determinants, marketing and advertising, taxes and pricing, availability and access, early diagnosis and treatment of disease, interventions in drinking environments, and safer untaxed alcohol products. Cost effectiveness analyses will be undertaken in multiple settings, geographical regions, and for different gender and age groups to guide integrated policy making to reduce the harm done by alcohol. Using time series analysis, longitudinal intervention research, policy mapping, cost effectiveness analyses, and other policy relevant research methodologies, recent and current alcohol policy changes will be evaluated throughout European Member States. Current alcohol policy related infrastructures will be documented and their impact on effective policy development and implementation analyzed. The interaction between social and cultural determinants of alcohol policy and policy and preventive measures will be studied to determine the extent to which the implementation and impact of effective alcohol policies is culturally determined. Methodologies will be developed to allow tools for benchmarking and comparative analysis at the European level, advancing the state of the art in alcohol policy research and enhancing cooperation between researchers in Europe and other geographic regions to promote integration and excellence of European research in alcohol policy. AMPHORA will provide the evidence base to inform policy and decision makers at European, national and local levels to implement effective interventions to reduce the harm done by alcohol throughout a wide range of policies implemented in different sectors and settings.

Keywords: policy,culture,price,marketing,availability,treatment,harm reduction,youth,gender,cost effective
MEDiterranean studies of Cardiovascular disease and Hyperglycaemia: Analytical Modelling of Population Socio-economic transitions (MEDCHAMPS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,Ireland,Türkiye,Palestine, State of,United Kingdom,Syrian Arab Republic,Tunisia
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-03-01
End date: 2013-02-28
Duration (months): 48.0
Total project cost (EUR): 3475608.2
EU funding (EUR): 2703358.0
Participants: 8
Project status: CLOSED

Non-communicable diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes are increasing dramatically in low and middle income countries. The main reasons for this are an increase in major risk factors, particularly increasing obesity [as a consequence of changes in nutrition and decreases in physical activity], and increasing tobacco use. Globalisation, urbanisation and an ageing population are contributing to this trend. A common misperception is that NCDs are diseases of affluence, but in fact they are common amongst poorer sectors of populations, and age-specific disease rates can be higher in developing countries than in industrialised settings. Health services in these countries, developed to tackle acute infectious diseases, are often not ideally organised to promote effective care and prevention for NCDs. This project will develop a CVD and diabetes model (IMPACT) for use in this region. After appropriate testing and validation, we will enter data from each of the four Mediterranean study countries (Palestine, Syria, Tunisia, Turkey) into the model, and validate results against current disease levels and trends. We will use a combination of situation analysis, policy and document review, and qualitative techniques to elicit the current state of NCD policy development in the study countries, and stakeholders’ perceptions of potentially effective interventions. We will then use the country validated models to assess the effectiveness and cost-effectiveness of selected future policies. Finally, we will develop implementation and evaluation plans for these policies in each study country. The goal of this project is to reduce the NCD burden of CVD and diabetes. The overall objective is to be able to make recommendations about the policy initiatives, both within and outside the health sector, likely to be the most effective and cost-effective in reducing the burden of CVD and diabetes mortality and morbidity in each country.

Keywords: epidemiology,modelling,cardiovascular,diabetes,health systems,policy
European Network of Bipolar Research Expert Centres (ENBREC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Coordination and support actions
Countries involved: France,Spain,United Kingdom,Italy,Germany,Norway
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-07-01
End date: 2011-06-30
Duration (months): 24.0
Total project cost (EUR): 877369.2
EU funding (EUR): 662900.0
Participants: 6
Project status: CLOSED

Bipolar (BP) disorder is characterized by recurrent manic and depressive episodes, affecting more than 1% of the EU population. Delay in the diagnosis (based only on clinical features), uncertainties in the definition of episodes and on the treatment strategy best adapted to each patient lead to devastating socio-economic, professional and family consequences that be reverted by optimized diagnostic and treatment procedures. ENBREC is designed to build an EU-wide network of expert centres specialising in research and care on BP disorder, in order to integrate research efforts on the mechanism of disease, and on optimized diagnostic and treatment. Common tools and practice, training and information will help structuring the EU BP research community and translate research outcome into healthcare, as listed in the work packages: WP1: Management of the project WP2: Developing common tools for diagnosis and multinational cohort follow-up WP3: Developing common tools for cognitive assessment WP4: Assessment of common biomarkers and genetic markers WP5: Development of standards for imaging WP6: Treatment optimisation, definition of subgroups of responders WP7: Supporting multinational clinical research and data management WP8: Education, information, dissemination, translation of research outcomes into healthcare WP9: Extension to new countries and within the countries The consortium currently covers networks of BP expert centres reaching the critical mass in Germany, Italy, Norway, Spain, UK, and France (representing more than 300 Millions EU citizens), and plans to extend to other EU member states. It also includes ECRIN, the FP7 infrastructure providing support to multinational clinical studies. Integration of EU research and care on BP disorder will benefit EU patients and citizens, restore EU leadership in BP research, strengthen drug development in the EU, in line with the expectations of the Innovative Medicines Initiative strategic research agenda.

Keywords: bipolar disorder - mood disorders - diagnostic tools - cognitive assessment - genetics - biomarker - imaging - treatment strategy - clinical research