Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cobalt and Lithium speciation, toxicity, and Bacterial community Regulations at the sediment-water-Interface (CoLiBRI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 2
Project status: SIGNED

In the EU, transport is responsible for a quarter of greenhouse gas emissions. For the transition to a climate neutral economy, battery development and production strategies are thus important. By 2030, the EU expects an increased requirement of 18 times more lithium and 5 times more cobalt. These elements are released into the aquatic environment by mining processes and wastewater discharge. In aquatic systems, sediments are important and dynamic sinks or sources for such elements, depending on varying environmental conditions. The chemical state, bioavailability, and toxicity of these elements in aquatic systems is highly influenced by environmental parameters such as pH and temperature, which in turn are influenced by climate change. The goal is to investigate the toxicity of lithium and cobalt in aquatic systems under different environmental conditions. This will be addressed in 3 research objectives: 1) Investigation of the impact of temperature and pH on the distribution and chemical characteristics of lithium and cobalt within aquatic systems 2) Analysis of toxic effects of lithium and cobalt to zebrafish 3) Evaluation of lithium and cobalt related microbial community changes within the sediment. To address these objectives, we will perform a long-term exposure with zebrafish to selected sediments spiked with lithium and cobalt in an aquarium system capable of monitoring and regulating different water parameters. The toxicity will be determined with the zebrafish embryo toxicity test. Gene-expression analysis will reveal sub-lethal toxic effects of the selected elements. Bioaccumulation and content of lithium and cobalt in water and sediment will be quantified by ICP-MS. Changes in the sediment microbial community will be investigated by metagenome fingerprinting. With this interdisciplinary holistic approach we aim to improve environmental risk assessment of sediments contaminated with lithium and cobalt, particularly in regard to climate change.

Keywords: zebrafish,sediment,lithium,cobalt,toxicity,bacteria,freshwater,metal speciation,climate change,sediment water interface
Structure-properties of melt-spun bioplastic fibers in correlation with their biodegradation behaviour and mechanical performance (PolyBioDeg)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 290663.31
EU funding (EUR): 203464.32
Participants: 2
Project status: CLOSED

Polymeric textile fibers, are one of the main sources of microplastics pollution in the open environment. The European Strategy for Plastics in a Circular Economy acknowledges the need for increased R&D on biodegradable polymers. A key challenge of biodegradable plastics is that the biodegradation rate and material performance (e.g. mechanical and thermal) very often oppose each other. It is therefore difficult to develop products that meet the performance requirements that users expect, and still offer a substantial ecological advantage through fast biodegradation in the open environment. It is of importance to the future health of humanity and the natural world that a well-performing, scalable, and affordable biodegradable textile fiber will be developed. As this is intrinsically difficult, we need more fundamental understanding on how molecular design parameters (e.g. chain stiffness and chain interactions) and physiochemical properties (e.g. crystallization) influence biodegradation behavior on the one hand and fiber spinning and fiber performance on the other hand. The key outcome of the project is a clear understanding of how we can influence the biodegradation of a fiber, whilst having a good spinning process and fiber performance. It is likely that besides understanding, actual novel biosynthetic fibers will be developed in this project. The applicant Dr. Mohammadreza Naeimirad is an expert in melt-spinning of fibers and he is supervised by Bas Krins from Senbis Polymer Innovations B.V. as the host organization, and Prof. Gert-Jan M Gruter from University of Amsterdam (UvA) for the secondment. Senbis provides unique expertise and facilities on melt-spinning and evaluation whereas the UvA does so in the area of synthesis and biodegradation.

Keywords: bioplastics,fiber melt spinning,polymer processing,biodegradation,environmental science
Towards a bio-mimetic sunlight pumped laser based on photosynthetic antenna complexes (APACE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Poland,Germany,United Kingdom
Call: EIC Pathfinder Challenge: In-space solar energy harvesting for innovative space applications (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3398692.5
EU funding (EUR): 3398692.5
Participants: 10
Project status: SIGNED

Creating new technologies towards long-term in space self-sustainability is essential to solve the problem of the increasing energy demand both in space and on Earth. Biology can provide the answer to this challenge, self-sustainability being the defining characteristic of life. APACE will demonstrate a novel type of bio-inspired sunlight pumped laser, based on photosynthetic complexes, that is capable of upgrading diffuse natural sunlight into a coherent laser beam. In the APACE core strategy, lasing units composed of engineered molecular systems or doped nanocrystals will be attached to a bacteria photosynthetic antenna complex to obtain an engineered photosynthetic antenna. The engineered antennae, dispersed in a polymeric matrix or in solution, will form a supramolecular gain medium, which will be placed in an optical cavity to build a sunlight pumped laser. Bacterial photosynthetic complexes are nanoscale molecular structures with the unique ability to funnel the collected solar energy with almost 100% efficiency. Exploiting these extraordinary properties, the APACE bio-inspired laser will be able to operate under unconcentrated sunlight, with at least two orders of magnitude enhanced efficiency over existing designs. APACE will thus lay the foundation for a novel solar harvesting technology that could ultimately be fabricated in situ on permanent space stations, and that may benefit from a similar scalability as photovoltaic panels. The collected energy can be used for in situ energy production (e.g. hydrogen generation) as well as for wireless power transmission to satellites or to Earth by infrared laser beams.

Keywords: quantum biology,laser physics,physical chemistry,organic chemistry,complex systems
A patient specific approach to tissue expansion in breast reconstruction (BreastRecon)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Breast cancer is the most prevalent cancer globally, affecting 13% of women in their lifetime. For those women who undergo a mastectomy, breast reconstruction has become an integral part of their treatment. While two stage implant-based reconstructions are by far the most common procedure, they are sub-optimal: They suffer from high complication rates and low patient satisfaction. The first stage of implant based reconstructions involves the insertion of a tissue expander, silicone implants gradually inflated below the skin over several weeks to induce new skin growth. Improving patient outcomes and patient satisfaction requires a deep understanding of the biomechanical mechanisms associated with growing new tissue and the challenges associated with predicting its future behaviour. However, the lack of adequate in vivo techniques to evaluate and predict the amount of tissue growth is an obstacle to effective surgical planning. BreastRecon aims to address these challenges by developing a novel acoustoelastic method which can non-invasively determine key biomechanical parameters. Specific objectives of BreastRecon include (i) the development of a wearable surface wave device for clinical in vivo measurements (ii) the quantification of in vivo tension using the device (iii) the non-invasive determination of tissue growth and (iv) the development of a real-time optimisation procedure for the design of tissue expansion protocols. To achieve these ambitious goals, BreastRecon employs a distinctive combination of acoustoelastic tissue measurements, physics-based machine learning techniques and novel device development. BreastRecon will initially provide a tool to monitor tissue growth in vivo, offering valuable fundamental insights into growth and remodelling processes. Ultimately, it will advance patient-specific tissue expansions by designing optimum protocols based on individual biomechanical measurements, offering a disruptive breakthrough in reconstructive surgeries.

Keywords: skin biomechanics,skin growth,rayleigh waves
Green Solar-to-propellant Water Propulsion (Green SWaP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Netherlands,Germany,Belgium,France
Call: EIC Pathfinder Challenge: In-space solar energy harvesting for innovative space applications (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3997916.25
EU funding (EUR): 3997916.25
Participants: 6
Project status: SIGNED

Similar to terrestrial photosynthesis, whereby plants convert solar energy into chemical energy through the capture of light energy, Green SWaP project seeks to harness this potentiality in space by converting water into highly valuable propellants, specifically hydrogen peroxide and hydrogen. Green SWaP will prove and validate a technology that will use solar energy to produce propellants from water for in-space green propulsion. It will be a crucial building block to enable innovative green propulsion solutions for in-space mobility, resulting in low-cost and eco-friendly innovative concepts. It is a novel approach, never developed for in-space mobility. Studies exist for terrestrial applications, but the space environment introduces additional constraints and dedicated challenges that the project will try to solve. The new technologies, based on innovative chemical processes, will harvest solar power to enable green propulsion. It is a plausible methodology because underlying technological concepts of producing/concentrating/storing hydrogen peroxide and hydrogen using solar energy have been proven (separately) even though for different constraints and conditions of use than in-space applications. Moreover, the combination of hydrogen peroxide and hydrogen has never been investigated in detail and the utilization of hydrogen for solar thermal propulsion is theoretically proven to be the most promising but it has never been developed as technology. The combination of these technologies will drastically increase future spacecrafts’ capabilities, facilitating renewable and self-sustainable in-space mobility. Optimisation concerning the quality and quantity of hydrogen peroxide and hydrogen produced onboard and the efficiency improvement will be fully explored.

Keywords: green propellants,solar to fuel,thermal solar propulsion,photo electro chemical pec,catalysis,non thermal plasma ntp,solar energy harvesting,space propulsion,in space mobility
Center of excellence for weather and climate phase 3 (ESiWACE3)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Spain,Netherlands,Germany,Finland,United Kingdom,Sweden,Italy,France
Call: Centres of Excellence for supporting supercomputing applications for Science and Innovation (HORIZON-EUROHPC-JU-2021-COE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 6081337.5
EU funding (EUR): 3040668.0
Participants: 12
Project status: SIGNED

This proposal shapes the next (third) phase of the ESiWACE Centre of Excellence. As the ability to run Earth system models at ~1km resolution efficiently on EuroHPC supercomputers has already been established in previous phases for specific model configurations, and as developments are now picked up by science-driven projects, this proposal will focus on the support of the community to reach a higher readiness level regarding exascale supercomputing and knowledge transfer between the different Earth system modelling centres and teams across Europe. The project will focus on three main aims that are essential to prepare existing, operational weather and climate prediction systems for the exascale era through (i) the transfer and establishment of knowledge and technology for efficient and scalable simulations of weather and climate across the Earth system modelling community, (ii) closing common technology knowledge gaps and by providing toolboxes for high-resolution Earth system modelling via joint developments and (iii) by serving as a sustainable community hub for training, communication and dissemination for high-performance computing for weather and climate modelling in Europe. ESiWACE3 will bring the various approaches to address these challenges from the different modelling groups together to transfer knowledge across the weather and climate domain, to generate synergies between the local efforts, to provide targeted support of modelling groups via customised high-performance computing services, and to provide training to educate the next generation of researchers.

Keywords: weather,climate,exascale,hpc,scalability,portability,simulation,co design,profiling and optimisation,workflow,computer science,data analysis,large data volume,optimisation services
Regulatory sequence evolution during major transitions in complex multicellularity in the brown algal radiation (PhaeoCREEvol)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: TERMINATED

Brown algae are a multicellular clade that display remarkable diversity in developmental and physiological complexity, and in life history traits. They evolved independently and more recently than animals and plants, making them a uniquely powerful system to characterise the genomic changes that underlie the emergence of complex multicellularity. I will specifically test the hypothesis that cis-regulatory element (CRE) evolution plays a leading role the evolution of complexity. Harnessing large-scale multiomics datasets, I will quantify lineage-specific rates of CRE gains and losses, and attempt to link these events to transitions in complexity. I will combine signatures of constraint from a 59-species whole-genome alignment with functional epigenomic data (ATAC-seq, ChIP-seq) from five representative species to produce fine-scale maps of deeply conserved and recently acquired CREs. To understand the mechanisms of CRE evolution, I will annotate transposable elements (TEs) and quantify variation in TE diversity, abundance and activity. I will characterise what roles TEs have had in CRE dissemination. I will also explore between-species variation in the proportion of proximal and distal CREs. I will analyse high-resolution Hi-C data for four species to ask what effect distal regulation has on 3D genome organisation (i.e. are distal CREs and the genes they regulate topologically associated?). PhaeoCREEvol will inform upon the rates and mechanisms of CRE evolution during the emergence of complexity, providing a highly pertinent comparison to animals and plants. This will increase our knowledge of regulatory evolution in general, while shedding light onto the fundamental biology of a largely unstudied eukaryotic group. Brown algae play critical ecological roles and have significant potential to mitigate climate change, enhance global food security, and deliver novel industrial solutions, providing key motivations to better understand their genetics and evolution.

Keywords: brown algal evolution,multicellularity and complexity,cis regulatory elements,transposable elements,3d genome organisation
Certification of real time guarrantees for reactive applications (Cert-T)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

The complexity to design IoT networks increases with the number of devices, sometimes even exponentially when each node is connected through the network to all other nodes. As a consequence, a local change in one of the nodes can have global implications on the emerging properties of the network. For instance, in the case of an automatic industrial process, machines operate in series on a product and the time and physical effect of each operation needs to be properly calibrated to get the expected result. There comes two main challenges: give a design framework with sufficient expressiveness to specify real time effects of programs (interaction with physical object); and provide formal tools to analyze the individual properties of each node, and the resulting property of the network. Ideally, the design of an application should be close enough to the programmer’s way of thinking, so that few errors are made at specification. Then, a compiler automatically transforms a program to a binary that a machine can executes. The correctness of a compiler lays in the semantic preservation theorem: the generated binary has the same behavior as the specification that the programmer wrote. The focus, however, has mostly been done on the preservation of memory properties, but not on time properties. My idea is therefore to extend the theoretical and practical tools used in compiler correctness to provide timing guarantees in the semantic preservation theorem. This challenge is ambitious as it would provide a new spectrum of certifications for hard real time applications; and is seen as the next big step for current compiler design. I will use some advance techniques from reactive programming and current knowledge in compiler correctness to provide real time certificates.
How Effective are Illiberal Strategies of Citizen Manipulation? (ICMAN)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Hungary
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 157622.4
EU funding (EUR): 157622.4
Participants: 2
Project status: SIGNED

The widespread popular support for illiberal leaders seeking to subvert democracy is one of the more puzzling and concerning developments in the 21st century. From Putin through Orbán to Erdogan, illiberal leaders invest large resources into propaganda, organize grandiose displays of support, and promote hostile rumours about their enemies. But do such attempts at manipulation shape citizens' support and acceptance of the illiberal leader? Prior research yields conflicting expectations. On the one hand, research in psychology and political behaviour identified a plethora of cognitive biases, which undermine citizens' ability to punish leaders for their mistakes or wrongdoings. On the other hand, recent evidence shows that people are difficult to persuade, making it unlikely that propaganda could change the minds of citizens who are critical of an illiberal leader. To adjudicate between these accounts, this project will a) develop a novel framework for studying the effects of illiberal manipulation strategies and will examine the effects of multiple manipulation attempts, such as b) hostile rhetoric, c) political misinformation campaigns, and d) populist appeals to fairness intuitions. The project builds on an interdisciplinary framework bridging insights from comparative politics and psychological science, and will employ a diverse set of methodological tools from multiple survey experiments (vignette, conjoint, and cultural transmission designs) as well as quantitative text analysis. Original comparative survey data from Hungary, the US, and Denmark will be used to compare citizens' susceptibility to manipulation under different political environments. The project contributes to the European Commission's priority of "a new push for European democracy" by informing pro-democracy stakeholders and citizens on the perils of illiberal citizen manipulation.

Keywords: manipulation,propaganda,illiberal regimes,democratic backsliding,hostility,misinformation,direct democracy