Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Factors driving mother-to-infant microbiota transfer (MicroMI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Human microbiota has vital effects on human health and physiology. Gut microbiota alteration has been linked to risk of non-communicable diseases (NCDs) as allergy, obesity and cardiovascular diseases. NCDs are increasing and account for more than 41 million people deaths per year (71% of all deaths globally), being more critical in infants. Early microbial colonization of the GIT is essential for an optimal health, thus, altered microbial colonization patterns have been linked to an increased risk of NCDs. Mother-to-infant transfer of microbes is believed to be a crucial opportunity to pass on IM from one generation to another, representing a pivotal step in the development of the early infant gut microbiota. Much research to date has addressed the impact of the environment on the microbiota composition, nowadays, is time to go further and to define this mechanism in a compositional, functional and metabolic level. An in-depth understanding of the effect of maternal IM in the early life and its long-term impact is urgently needed. The EU is promoting actions developing new dietary solutions to improve public health, therefore, MicroMI aims to make a novel approach by using state-of-the-art methodologies already established within the host institution (CSIC) to reveal the mechanisms underlying this host-microbe interaction in the GIT development and maturation in early life. MicroMI adapts methods based on cutting-edge sequencing technologies to gain knowledge on probiotic-related issues. This project will positively impact on the European society and economy. Within MicroMi, the applicant will perform state-of-the-art research, will promote science as a career and gender equality and she will establish an innovative translation multidisciplinary programme. Funding of this action will allow the research applicant to foster and share her skills and reinforce herself as a mature and independent professional, starting to forge a stable career.

Keywords: microbiota,metagenomics,mother to infant transfer,host microbe interaction,probiotics
Turning a Blind Eye to Scandal (TURNEYES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2025-01-30
Duration (months): 36.0
Total project cost (EUR): 271732.8
EU funding (EUR): 271732.8
Participants: 2
Project status: SIGNED

Why are some politicians electorally ‘punished’ for immoral behavior while others are not and how can we explain voters’ heterogeneous responses to identical moral transgressions? Despite decades of study, these two questions remain unanswered. Understanding voters' responses to politicians’ immoral behavior is important as scandals reduce citizens’ trust in both politicians and the political system, and lead to dissatisfaction with representative democracy. When politicians can avoid accountability for immoral actions, they may be personally protected from consequences, yet democracy itself suffers. Our knowledge of political scandals is seriously limited by (1) not considering voters’ moral principles and moral identity, (2) using self-reports of emotional responses and (3) not studying politicians’ moral violations in the context of complex election campaigns. This groundbreaking study, 'Turning a Blind Eye to Scandal’ provides a testable theoretical model of voter response to political scandal. It takes an interdisciplinary approach by (a) integrating social-psychological theories such as Moral Identity Theory and Moral Foundation Theory with political science theories of expressive partisanship and affective partisan polarization and (b) employing a unique multimethod design combining survey embedded vignette experiments with innovative laboratory experiments using Dynamic Process Tracing and psychophysiological measures. This study is the first to examine how voters’ responses to politicians’ moral transgressions -including voting behavior- are driven by (1) individual characteristics such as voters’ moral identity, moral principles and partisan identity, and (2) characteristics of the political context such as affective polarization. This fellowship brings together research expertise from the University of Nottingham and the University of Delaware and trains the applicant for cutting-edge research and future academic leadership in political psychology.

Keywords: political scandal,moral transgressions,partisan identity,affective partisan polarization,democratic accountability
Plastic litter in macrophyte system: environmental fate and ecological implications (SCRAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

Plastic is an emerging environmental contaminant that attracts social, political, and scientific attention. However, the effect mechanisms and ecological conditions that promote the consequences of plastic littering remain elusive because of the single-species approach in ecotoxicological testing. To make regulatory decisions mitigating the problem, the potential impacts and vulnerable habitats must be identified. In aquatic ecosystems, macrophyte beds are often a templet habitat providing foraging grounds for pelagic and benthic food webs. These systems are also at the forefront of plastic littering, with high fragmentation and accumulation of microplastic. I propose to conduct a systematic study to understand the multiple interactions between the key components in a coastal habitat exposed to plastic littering. Using the keystone macroalgae species in the Baltic, Fucus vesiculosus, this project aims to evaluate the microplastic effect mechanisms that are related to the species interactions in seaweed beds, with a microbiome being the key component mediating these interactions as well as microplastic retention in the system. I will also investigate the potential of the macrophyte habitat as an entrance point for microplastic in the food web, with particular focus on the primary consumers with different feeding modes. To evaluate the ecosystem health posed by microplastics, the project will also examine effects of microplastic and their leachates on plant physiology, including its growth and metabolite production. Finally, I will evaluate the effects of microplastic exposure on the macrophyte templet functions, including energy transfer efficiency and heat wave resilience. This framework will provide an understanding of the pathways, fate and effects of plastic debris in macrophyte system as well as an approach that applies to other anthropogenic contaminants released into the environment as particulates.

Keywords: marine debris,plastic pollution,microplastic,macrophyte,macroalgae,seaweed,biofilm,bioinformatics,plant physiology
NEUro cerebellar recurrent network for motor SEQuence learning in neuroroBOTics (NEUSEQBOT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-11
End date: 2024-01-10
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: SIGNED

The new generation of compliant robots, designed to safely interact with humans in unstructured environments, require control systems able to naturally deal with their “biological features”. These robots can be efficiently controlled using biologically inspired control systems based on brain regions such as the cerebellum. This nucleus plays a key role in fluent body movements, being essential for adaptive motor control and coordination of body movements. The cerebellum was traditionally modelled as a feedforward network with two inputs and one output. Nevertheless, recent experimental studies have demonstrated the existence of multiple recurrent connections in the cerebellum: 1) nucleo-cortical connections (NCCs), and 2) nucleo-olivary connections (NOCs). These recurrent connections back-propagate the cerebellar output activity to the cerebellar inputs, thus shifting the feedforward toward a recurrent approach. NEUSEQBOT project will focus on the NCCs, studying how they contribute to the motor sequence learning capabilities in the cerebellum. This multidisciplinary study will combine neuroscientific experiments in animals, cerebellar modelling and neurorobotic applications. Firstly, we will experimentally study the NCC effect in the cerebellar dynamics during reflexive eyelid movements in optogenetically modified mice. The experimental results will be used to model a recurrent cerebellum. Finally, this cerebellar model will be tested in a neurorobotic object manipulation task using a compliant robotic arm. Within the objectives of H2020, NEUSEQBOT project aims to advance our understanding of how the cerebellum (as a recurrent network) processes the sensorimotor information to generate the required motor command sequences, applying this knowledge to develop biologically inspired control systems for neurorobotic applications with compliant robots. This work will enable the experienced researcher to enhance his position at the forefront of advances in these fields.

Keywords: cerebellar modelling,recurrent neural networks,spiking neural networks,cerebellar motor sequence learning and production,neurorobotic applications,compliant robots,experimental neuroscience
ESTABLISHING FUTURE-ORIENTED TRAINING AND QUALIFICATION QUALITY STANDARDS FOR FOSTERING A BROAD UPTAKE OF SUSTAINABLE ENERGY SKILLS IN THE EUROPEAN CONSTRUCTION SECTOR (TRAIN4SUSTAIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Spain,Germany,Italy,Hungary,France
Call: Stimulating demand for sustainable energy skills in the construction sector (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-05-01
End date: 2022-10-31
Duration (months): 30.0
Total project cost (EUR): 994375.0
EU funding (EUR): 994375.0
Participants: 7
Project status: CLOSED

TRAIN4SUSTAIN (T4S) will stimulate demand for skilled construction sector professionals (architects, contractors-SMEs and workers) through raising acceptance of regional and national qualifications and skills on the EU construction market. To this end, comparability of national qualifications and sustainable energy skills is key for increased transparency and penetration power in the market. T4S will tackle the issue of mutual recognition so that training accredited in one country is recognised easier in another country. Taking advantage of already available transnational energy skill qualification frameworks for building professions, like the BUILD UP Skills initiative, Prof/Trac scheme or the ones produced by the BIM community, and the recently developed EU framework for energy and resource efficient buildings (e.g. Level(s) ), T4S will focus on acting at market level. T4S project will foster a common understanding of sustainable energy skills across Europe by promoting a competence quality standard, a European Skills Registry and a Skills Passport for facilitating transnational recognition of learning outcomes and skill levels of existing qualifications and vocational trainings.

Keywords: training,sustainability,qualification skills
Ultrasensitive Nano-Optomechanical Sensors (Atto-Zepto)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France,France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2067905.0
EU funding (EUR): 2067905.0
Participants: 2
Project status: SIGNED

By enabling the conversion of forces into measurable displacements, mechanical oscillators have always played a central role in experimental physics. Recent developments in the PI group demonstrated the possibility to realize ultrasensitive and vectorial force field sensing by using suspended SiC nanowires and optical readout of their transverse vibrations. Astonishing sensitivities were obtained at room and dilution temperatures, at the Atto- Zepto-newton level, for which the electron-electron interaction becomes detectable at 100µm. The goal of the project is to push forward those ultrasensitive nano-optomechanical force sensors, to realize even more challenging explorations of novel fundamental interactions at the quantum-classical interface. We will develop universal advanced sensing protocols to explore the vectorial structure of fundamental optical, electrostatic or magnetic interactions, and investigate Casimir force fields above nanostructured surfaces, in geometries where it was recently predicted to become repulsive. The second research axis is the one of cavity nano-optomechanics: inserting the ultrasensitive nanowire in a high finesse optical microcavity should enhance the light-nanowire interaction up to the point where a single cavity photon can displace the nanowire by more than its zero point quantum fluctuations. We will investigate this so-called ultrastrong optomechanical coupling regime, and further explore novel regimes in cavity optomechanics, where optical non-linearities at the single photon level become accessible. The last part is dedicated to the exploration of hybrid qubit-mechanical systems, in which nanowire vibrations are magnetically coupled to the spin of a single Nitrogen Vacancy defect in diamond. We will focus on the exploration of spin-dependent forces, aiming at mechanically detecting qubit excitations, opening a novel road towards the generation of non-classical states of motion, and mechanically enhanced quantum sensors.

Keywords: optomechanics,nanomechanics,casimir force,quantum optics,ultrasensitive force sensors,spin qubit
Seizure Risk Asessment for Epilepsy (SERAS_v4.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-04-01
End date: 2022-03-31
Duration (months): 36.0
Total project cost (EUR): 2568300.0
EU funding (EUR): 1797810.0
Participants: 1
Project status: CLOSED

MJN Neuroserveis’ has developed SERAS, a non-invasive, discrete and wearable device that predicts an epileptic seizure before it occurs. The device consists of an earpiece that reads the electroencephalogram, and a cloud-connected mobile application containing an artificial intelligence algorithm that alerts the user, their environment, and medical services one minute before a seizure occurs. In addition, the device permanently monitors a patient's brain activity, allowing for the generation of medical reports, the number of seizures suffered, their intensity and frequency. Currently, doctors who care for these patients do not have the data to allow for targeted patient treatments. Today, there is no device clinically validated in the market with these functionalities that can permanently monitor brain activity in a discrete, portable and continuous way. Around 50-65 million people suffers from epilepsy worldwide, depending on source. These people live in a permanent state of uncertainty, caused by not knowing when they will suffer the next seizure and if it could cause a serious accident for them. SERAS is a disruptive solution unique in monitoring brain signals and predicting epilepsy seizures with enough time to avoid accidents. MJN is a business moved by high social impact vision; our claim is ‘Quality of life for everybody’. We face a market of 6 million epileptic people in EU and USA. We aim to become a new benchmark on a global scale in the digital health world related with neurological diseases. SME Instrument Ph2 project will help us to improve our prediction algorithm in order to automate learning process and create a platform to exploit data recorded from users of the device. This will allow us and doctors go a step further on research of neurological pathologies. By Ph2 project we will accelerate our commercialization plan to scale-up our business to the goal of €27 million turnover by 2025.

Keywords: epilepsy,seizures,prediction algorithm,brain activity,safety,technology,ehealth,digital health
Gravity, Inflation, and Galaxies: Fundamental Physics with Large-Scale Structure (GrInflaGal)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 1330625.0
EU funding (EUR): 1330625.0
Participants: 1
Project status: CLOSED

Over the past two decades, a data-driven revolution has occurred in our understanding of the origin and evolution of our Universe and the structure within it. During this period, cosmology has evolved from a speculative branch of theoretical physics into precision science at the intersection of gravity, particle- and astrophysics. Despite all we have learned, we still do not understand why the Universe accelerates, and how the structure in the Universe originated. Recent breakthrough research, with leading contributions by the PI of this proposal, has shown that we can make progress on these questions using observations of the large-scale structure and its tracers, galaxies. This opens up a fascinating, new interdisciplinary research field: probing Gravity and Inflation with Galaxies. The goal of the proposed research is to first, probe our theory of gravity, General Relativity, on cosmological scales. Second, it aims to shed light on the origin of the initial seed fluctuations out of which all structure in the Universe formed, by constraining the physics and energy scale of inflation. While seemingly unrelated, the main challenge in both research directions consists in understanding the nonlinear physics of structure formation, which is dominated by gravity on scales larger than a few Mpc. By making progress in this understanding, we can unlock a rich trove of information on fundamental physics from large-scale structure. The research goals will be pursued on all three fronts of analytical theory, numerical simulations, and confrontation with data. With space missions, such as Planck and Euclid, as well as ground-based surveys delivering data sets of unprecedented size and quality at this very moment, the proposed research is especially timely. It will make key contributions towards maximizing the science output of these experiments, deepen our understanding of the laws of physics, and uncover our cosmological origins.

Keywords: modified gravity,inflation,gravitational waves,large scale structure,galaxies,galaxy clusters
[18F]Fluorination of alkylCF3 and alkylCF2CF3 chains-Application to hypoxia biomarkers for PET imaging. (HYPOXFLU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-03-16
End date: 2017-03-15
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride. The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5. We propose to develop an automated protocol for the production of their radiolabelled counterparts, and to perform a pre-clinical comparative study of [18F]EF3 and [18F]EF5 with [18F]FMISO, the current hypoxia biomarker used for PET imaging.

Keywords: fluorine chemistry,18f radiochemistry,biomarkers