Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tropical Differential Geometry (TROPDIFFGEO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-12-01
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The all-pervading utility of differential equations, and therefore of methods for their solution, in mathematics and the physical sciences, especially in mechanical and electronic engineering, is undisputable. The heat and wave equations are star examples. The subject has a long history, including its interactions with modern algebra since it was brought into that framework by Ritt in the late 1930s. Tropical geometry, introduced two decades ago, is a rapidly developing area of mathematics offering a new approach to algebraic and geometric problems, for instance, counting solutions to equations. "Tropicalising" these problems turns them into new problems stated only in terms of ensuring that collections of linear functions are tied for the greatest value, which have the same answers as the originals but can often be easier to solve. In 2015, the Fellow and others introduced an application of tropical tools to differential algebra. Inspired by the initial successes of these methods, we are here proposing to extend them to classes of differential equation not yet handled, to bring more algebro-geometric machinery to bear, to transfer further aspects of the theory of tropicalisation of algebraic varieties to differential algebra, and to extend the computational algebra which motivated Grigoriev's interest to our new settings.

Keywords: tropical geometry
Production of renewable methanol from captured emissions and renewable energy sources, for its utilisation for clean fuel production and green consumer goods (CIRCLENERGY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Iceland
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Headquartered in Reykjavik, Iceland, Carbon Recycling International (CRI) is the world leader in power to methanol technology. The company has accumulated a decade of experience in solving the problems of economical CO2 capture and valorisation as well as reliable and cost effective large-scale production of hydrogen by electrolysis. CRI invented a new integrated process for sustainable low-carbon intensity fuel production. CRI’s Emissions-to-Liquids (ETL) technology has been scaled up from a laboratory scale pilot to an operating industrial scale plant with a capacity of 4,000 tons/year methanol production. Low carbon intensity methanol production with CRI technology reduces carbon emissions by more than 90% compared to fossil fuels. ETL is a sustainable process of renewable fuel production which has no impact on our food chain or land use. Methanol produced by CRI can also be directly used in the chemical industry for the manufacturing of sustainable goods such as paints and plastics. CRI aims to up-scale its current plant scale and offer a standard, modular ETL plant design with nominal 50.000 t/yr methanol production capacity. The improved ETL technology achieved with the current innovation project, will enable CRI to efficiently operate using variable power sources or stranded energy assets. One of the defining characteristics of renewable power sources such as wind and solar is their interment and variable production levels. High capacity factor production sites are often untapped or under-utilized due to the lack of adequate transmission line access or capacity. CRI will provide a means to valorise under utilized renewable energy sources. Our mission is that by 2022 in total 1million tn/yr methanol capacity is commissioned. This corresponds to 1.45 million tonnes of CO2 recycled per year. With a proven and scalable technology, based on predictable costs, limited competition and vast market potential, CRI has a strong foundation to achieve its mission.

Keywords: co2 recycling,co2 capture,emissions reductions,renewable energy,energy storage,grid stabilization,circular economy,renewable fuel
Lowering Costs by Improving Efficiencies in Biomass Fueled Boilers: New Materials and Coatings to Reduce Corrosion (BELENUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Germany,Spain,Sweden,Sweden,Finland,France,France,United Kingdom,United Kingdom,Portugal
Call: Developing solutions to reduce the cost and increase performance of renewable technologies (H2020-LC-SC3-2018-RES-TwoStages, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 4991323.75
EU funding (EUR): 4991323.75
Participants: 16
Project status: SIGNED

The primary objective of BELENUS is to lower bioenergy CAPEX and OPEX by an average of 5 and 60% respectively. This will be addressed by preventing or mitigating corrosion as the main limiting factor through a holistic approach to prevent corrosion in the boiler, in particular in superheater (SH) tubes: a) new surface engineering: biomass corrosion highly resistant coatings on creep resistance materials; b) new strategies of welding and bending for coated tubes improving the quality and efficiency of boiler components; and c) new online corrosion monitoring system specifically designed for biomass CHP plants. In addition, the BELENUS solution will impact on other LCOE parameters by improving efficiency in the conversion (up to 42%), increasing a 5% the operational hours of the plant and plant life time (5 years) and reducing the fuel expenditure of the plant by optimising its use and providing flexibility by allowing the use of different types of biomass. Improved performance for high temperature material systems through the technological breakthroughs, will be evaluated and validated an innovative test protocol. Finally, modelling and lifetime prediction tools will be developed and cost analysis and Life Cycle Analysis (LCA) undertaken so the optimum materials and coatings are chosen from the durability, economic and environmental perspectives, maximising the sustainability in economic and environmental terms. BELENUS brings together a multidisciplinary consortium comprising the main stakeholders with leading utilities, steel and tube developers, boiler designer and specialized research institutions from across Europe. This synergy allows a direct transfer of results in TRL5 to be obtained in BELENUS as technical base to go further to higher TRL into commercial biomass electric power plants within less than 5 years.

Keywords: biomass corrosion,efficiency,lifetime,protective coatings,materials,corrosion monitoring,chp plants,power plants
SYNBIO.ECM: Designer extracellular matrices to program healthy and diseased cardiac morphogenesis (SYNBIO.ECM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-12-01
End date: 2025-11-30
Duration (months): 60.0
Total project cost (EUR): 1999375.0
EU funding (EUR): 1999375.0
Participants: 1
Project status: SIGNED

To meet medical needs worldwide, tissue engineering must move from successful pre/clinical products towards an effective process to meet Worldwide medical needs, but this is challenging since a quantitative design framework has not emerged, yet. Synthetic biology (SYNBIO) was the solution that genetic engineers found to the same problem: “Despite tremendous individual successes in genetic engineering and biotechnology […], why is the engineering of useful synthetic biological systems still an expensive, unreliable and ad hoc research process?” asked Dr. Endy in a 2005 letter to Nature. The SYNBIO solution included: i) libraries of DNA parts with well-characterized effect on cells; ii) tools to computationally design system-level assemblies, or designer-DNA; and, iii) bottom-up engineering of cell functions using progressively more complex designer-DNA. Effectively, SYNBIO introduced a computer-aided design and manufacturing (CAD/M) platform that transformed the process of engineering cells. However, since inputs from the extracellular matrix (ECM) have largely been ignored, progress towards programmable tissue-level behavior have been more modest. Here, we will build on my experience with computational and experimental models in cardiac tissue engineering to develop a CAD/M framework for engineering cardiac tissues with computationally predictable properties, or designer-ECM. To characterize ECM-cell interactions, we will use traction force and super-resolution microscopy with fluorescence in-situ sequencing. To model multiscale ECM-cell interactions, we will use ordinary differential equations and subcellular element models. Finally, we will leverage ECM parts and human induced pluripotent stem cells to bioprint designer-ECM that recapitulate three phases of heart development: trabeculation, compaction, and maturation. With synthetic matrix biology (SYNBIO.ECM), we will develop a CAD/M-based process and a new class of products for cardiac tissue engineering.

Keywords: extracellular matrix,congenital heart disease,synthetic biollogy
Development of scalable microfluidic device for drug testing using humanized adipose tissue spheroids (SMD-SPH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

In regenerative medicine, in vitro tissue engineering products (3D cell cultures) for in vivo therapy are critical for more accurate and more humane medical innovation. Tissue engineered scaffold-free 3D models that exhibit functional hallmarks of native tissues improve our search for biomarkers, drug testing/development and toxicology with more accurate models, while supporting the development of alternative methods to animal use in drug testing, as stated by the Directive (2010/63/EU) established the European Centre for the validation of alternative methods (ECVAM). To replace animal testing, it is important to develop microphysiological systems and ‘body-on-chip’ approaches that allow to account for organ-to-organ interactions in vitro, at a reasonable cost. Yet, most current bioreactors are expensive, designed for organ transplant (thus focused on a single organ) and poorly designed for miniaturization and scale-up. In SMD-SPH, we will develop a microphysiological systems with the following design requirement: a 3D cell culture model, with a continuous and controllable perfusion system for continuous contact with morphogens (growth factors) to obtain a functional native tissue and monitoring crucial parameters of cell physiology, compatible with scale-up manufacturing. To the best of our knowledge, it is the first time in scientific literature that human adipose tissue-derived stem cells are used to build human white adipose tissue in a novel and scalable microphysiological system. This project meets the convergence of microfluidics and scaffold-free 3D culture models offering a reliable alternative for drug and toxicology assays, besides offer a scalable and reproductible system for future integration into a human-on-a-chip and high-troughput assays. Once an initial prototype is obtained, we will start dissemination to stakeholders and seek early adopters, cosmetic industries.

Keywords: microfluidics,human adipose tissue derived stem cells,scaffold free tissue engineering,spheroids,organ on a chip
SIGNIA: An innovative drug discovery platform for rapid identification and validation of antimicrobial applications in available pharmaceutical resources and drugs open for repurposing. (SIGNIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The economic and social burden of infections is being enhanced by the emergence of drug-resistant pathogens. This phenomenon is outpacing the industry’s capacity for drug discovery and development. Antimicrobial resistance is costing the EU today €1.5 billion and 25,000 deaths annually. Developing de novo classical drugs is very costly and time consuming, and for every new drug released a resistant strain has rapidly emerged. This paradigm is hindering our ability to respond to outbreaks. Among causative organisms, viruses pose a major threat, being responsible for the outbreaks impacting the world in the past decade (SARS, Influenza A, MERS, etc). Although some antivirals have been developed for them, they lose their efficacy rapidly due to the high mutation rate of viruses, which alters the antigenic features originally used to develop the drug. Thus, there is an urgent need for novel discovery methods that allow to accelerate the development of broad-spectrum and mutability-independent antimicrobials. In response, Signia Therapeutics has developed and validated a drug discovery platform for fast identification of compounds with antimicrobial activity. Instead of selecting drugs that target pathogen determinants, it selects drugs that target determinants of the infected cell. This method offers key advantages: i) avoids the impact of microbe intrinsic mutability; ii) broad spectrum drugs can be identified. Since the platform seeks for antimicrobial applications among drugs already commercialized (repurposing) and among pharma libraries (recycling), drug discovery becomes faster, safer and cost-efficient. Having reached the functional stage (TRL6), this project encloses the roadmap to finalise the platform’s development and its preparation for market. Once completed, this project will have huge impacts for society (better management of infections and preparedness against outbreaks), and for our company (expected ROI of €2.1 from this project after 5 years).

Keywords: antimicrobials,drug discovery,antimicrobial resistance,repurposing,drug screening,respiratory infections,pandemic diseases
Takeafile: A peer-to-peer online platform to transfer files of any size at maximum speed and in a secure way. (Takeafile)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Takeafile is a disruptive service that will allow professionals to channel all their data transfer needs in a single platform, so they can send files faster than with the alternatives (up to ten times faster), without size limitation of the files sent and in a purely confidential way. To this end, Takeafile distinguishes itself from the sharing services proposing a unique way of sending files without the need of intermediate servers, using a peer-to-peer transfer strategy, where the file goes direct from one computer to another computer, using the shortest way.

Keywords: webrtc,file transfer,peer to peer,web service
Identity and Memory in Christian Nubia: A study on strategies of (self-)presentation and preservation of the past in medieval African society (IaM NUBIAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

In 652 CE the successful expansion of Islam into Africa was halted at the gates of Dongola. While the historical significance of this ‘Nubian dam’ is well known, its sociocultural dimension also for subsequent developments in the region remains completely unexplored. IaM NUBIAN addresses this gap by examining how Nubian identity was shaped in the aftermath of this world-historical event and how it changed over time to witness the rise to glory and eventual fall of Christian Nubia in the 15th century. Using the extensive, but hardly exploited written evidence (documentary and literary) produced inside and outside Nubia in 4 languages (Greek, Coptic, Old Nubian, and Arabic), I will study textual and contextual means of expressing ‘Nubianness’ in 4 case studies on (1) linguistic strategies of (self-) presentation, (2) gender-determined identity, (3) the role of inscriptions in public space, and (4) how external sources presented Nubians. For the first time in Nubian studies, traditional historical disciplines (e.g. philology, papyrology, epigraphy, history) will be combined with insights from social sciences (sociolinguistics, identity and memory studies) and statistics to unlock the sophisticated interplay of text and context that underlies the studied writings. Moving well beyond the boundaries of current knowledge and approaches, IaM NUBIAN shifts the focus from the political-religious to the sociocultural to understand the historical processes that shaped medieval Nubian society. IaM NUBIAN is best executed in the Leiden Institute for Area Studies with its interdisciplinary approach to studying society at large, while Freie Universität Berlin offers crucial additional digital humanities and sociolinguistic expertise. Through an intensive cooperative and interactive research and training programme I will gain crucial linguistic, disciplinary, and professional skills, which will put me in position to obtain an ERC Consolidator Grant and a permanent academic position.

Keywords: christian nubia,nubian egyptian relations in middle ages,muslim christian relations
Launching the First One-Stop Video Game Culturalization Management Platform (AltaGram 4.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Game culturalization is a complex process that involves many specialists: specialized translation (localization), software interventions, design adaptation interventions, video captions, voice-over and transcriptions, conversion of requirements and addressing regional, national and local regulations. Whilst there are many localization (specialized translation) agencies, the video game industry lacks a unified solution to facilitate culturalization activities. As a result, games are full of inconsistences in the final contents, the process is costly, time consuming and lacks expertise. Our Solution Altagram 4.0 represents an innovative and disruptive one-stop web solution that optimizes and largely automates the culturalization process of video games. At Altagram GmbH, we are the one-stop solution for video game localization and culturalization. The overall objective of the Phase II is to transition our corporate strategy as service provider to become a service and product provider. We will achieve this by scaling our existing platform Altagram which is in its version 3.0 into the full 4.0 version. We will a) beta-test the current AltaGram 3.0 platform with external users, b) launch our marketplace functionalities to open up to further users and c) design and integrate semantics/deep learning. The specific objectives of Phase I Feasibility are: Technological Feasibility Study, Assess ment of the Market, Business Model, Risk and IP as well as a Work Plan for Phase II and Business Plan. We are a European company and our freelancers are all based in Europe and our team consists of Europeans. We bring revenues to Europe from our clients spread in four continents. Our aim is to contribute to Europe being the most integrated and culturally sensitive in can be. And, for European game companies/publishers to help them successfully enter foreign markets by having culturally adequate and relevant game contents, especially bridging the East-West divide.

Keywords: video game culturalization,automatic culturalization,semantics,artificial intelligence,deep learning,multimedia database management,api integration