Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An Educational Tool for the Assessment of Cross-linguistic and Intercultural Mediation Competences. (CLAIM-Tool)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: SIGNED

Intercultural competence (IC) is increasingly recognized as a core competence to be developed through formal education in order to prepare learners for a successful life and career in an intercultural world. These days, teachers and educational institutions are facing a challenging task of defining and assessing intercultural learning outcomes, especially as available IC assessment tools and frameworks are under fire by many experts in the field, who continuously stress the urgency to develop more valid and reliable measures to assess IC. So far, criticism by IC experts has been presented in the form of detailed feedback on available IC assessment tools accompanied by suggestions for the development of better assessment tools, yet, up to this date, and despite urgent calls on the matter, no attempts have been made to actually develop and test such a tool. Hence, the proposed CLAIM-Tool project aims to present a solution to an imperative and critical matter in intercultural education by producing an IC assessment tool based on the extant wealth of feedback from IC critics and in accordance with the EU policies on intercultural and plurilingual education. This project is an original work and a first attempt at developing a much needed IC tool, which, for the first time, combines theories and practice from both IC education and plurilingual education. It will contribute to a better understanding of IC assessment in foreign language education, which is an area of concern and much debate, and it will also contribute to better understanding of factors affecting IC assessment and the washback effect of conducting such type of assessment, which are two understudied areas in intercultural research. The CLAIM-Tool project will be carried out by an experienced researcher in the field of intercultural education, and in cooperation and under supervision of an expert supervisor who has a strong background in multicultural and plurilingual education.

Keywords: intercultural competence,foreign language learning,cross linguistic mediation,intercultural assessment,e learning
Selective Molecular Approaches to Remove Trypanosomiasis (SMART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-04
End date: 2023-10-03
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

African trypanosomiasis (AT), caused by the protozoan parasite Trypanosoma spp., is a debilitating disease that threatens millions of people in Sub-Saharan Africa. The human disease evolves in two stages, the second of which causes a fatal neurological infection if left untreated. The recent discovery of the orally-bioavailable drug fexinidazole, and its current use as a first-line treatment, has significantly improved disease outcomes associated with AT. However, the risk of resistance to fexinidazole treatment is a major concern that highlights the need for new treatment options. G-quadruplexes (G4s) are non-canonical DNA secondary structures that have recently emerged as an attractive target to fight AT. For example, recent studies have revealed the killing properties of a well-characterised G4-ligand, quarfloxin, against T. brucei parasites, showing the great potential for G4-targeting approaches to treat AT. However, the fundamental role of G4s in trypanosome biology and their validation as therapeutic targets have not been elucidated. In this proposal, I aim to unravel the biological functions of G4s in trypanosomes using integrated chemistry and genomic approaches. Specifically, peptide-based molecules designed to selectively target trypanosome G4s (TG4) will be developed and biophysically validated. The TG4-selective peptides will be used to functionally interrogate the trypanosome genome and to understand the effect of G4-modulation on gene expression using transcriptomics. Finally, our peptides will be engineered into fluorescent probes to facilitate real-time molecular visualisations of TG4s formation in vitro, and to provide an in-depth characterisation of these structures as novel targets to combat AT.

Keywords: trypanosoma brucei,g quadruplexes,dna secondary structures,therapeutic target,african trypanosomiasis,peptides,genomics,transcriptomics
eHealth in Rheumatology (ELECTOR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Czechia,Netherlands,Netherlands,Denmark,United Kingdom,Denmark,Denmark,Denmark
Call: Self management of health and disease: citizen engagement and mHealth (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-01-01
End date: 2018-09-30
Duration (months): 45.0
Total project cost (EUR): 3621584.95
EU funding (EUR): 3621584.95
Participants: 8
Project status: CLOSED

The increasing number of chronic patients in rheumatology calls for further development of the traditional methods for monitoring symptoms. The aim of the ELECTOR project is to develop a web-based ICT platform for home-based monitoring of self-reliant patients with rheumatoid arthritis. This will provide clinicians with a tool that can completely substitute a large proportion of the conventional visits at a rheumatologic outpatient clinic. The solution will encompass point-of-care devices for the measurement of biochemistry at home and a web-based user interface for reporting questionnaires as well as swollen and tender joints. The end result is an eHealth solution that will provide an integrated and direct collection of data into patient notes in the setup of an e-Health clinic. This solution will constitute a reliable, safe and straightforward method for obtaining self-assessments and facilitate easy and rapid access to health care assistance at times of need for the individual patient.

Keywords: rheumatology and ict,ehealth and research and device technology and software development and patient reported outcomes
Building sustainable logistics through trusted collaborative networks across the entire supply chain (NEXTRUST)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Germany,Italy,Austria,Austria,Germany,Belgium,Belgium,Switzerland,Norway,Belgium,Belgium,Belgium,Poland,Slovakia,Belgium,France,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Fostering synergies alongside the supply chain (including e.commerce) (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-10-31
Duration (months): 42.0
Total project cost (EUR): 18106750.0
EU funding (EUR): 18000000.0
Participants: 36
Project status: CLOSED

NEXTRUST objective is to increase efficiency and sustainability in logistics by developing interconnected trusted collaborative networks along the entire supply chain. These trusted networks, built horizontally and vertically, will fully integrate shippers, LSPs and intermodal operators as equal partners. To reach a high level of sustainability, we will not only bundle freight volumes, but shift them off the road to intermodal rail and waterway. NEXTRUST will build these trusted networks ideally bottom up, with like-minded partners, adding multiple layers of transport flows that have been de-coupled and then re-connected more effectively along the supply chain. We will develop C-ITS cloud based smart visibility software to support the re-engineering of the networks, improving real-time utilization of transport assets. NEXTRUST will focus on research activities that create stickiness for collaboration in the market, validated through pilot cases in live conditions. The action engages major shippers as partners (Beiersdorf, Borealis, Colruyt, Delhaize, KC, Mondelez, Panasonic, Philips, Unilever) owning freight volumes well over 1.000.000 annual truck movements across Europe, plus SME shippers and LSPs with a track record in ICT innovation. The pilot cases cover the entire scope of the call and cover a broad cross section of entire supply chain (from raw material to end-consumers) for multiple industries. The creation and validation of trusted collaborative networks will be market oriented and implemented at an accelerated rate for high impact. We expect our pilot cases to reduce deliveries by 20%-40% and with modal shift to reduce GHG emissions by 40%-70%. Load factors will increase by 50%-60% given our emphasis on back-load/modal shift initiatives. NEXTRUST will achieve a high impact with improved asset utilization and logistics cost efficiency, creating a sustainable, competitive arena for European logistics that will be an inspirational example for the market.

Keywords: trusted collaborative networks,horizontal and vertical collaboration,sustainability
Small farms, small food businesses and sustainable food security (SALSA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Greece,Poland,Norway,Tunisia,Romania,Latvia,Cabo Verde,Ghana,United Kingdom,Kenya,United Kingdom,Portugal
Call: Small farms but global markets: the role of small and familiy farms in food and nutrition security (H2020-SFS-2015-2, 2015)
Start date: 2016-04-01
End date: 2020-07-31
Duration (months): 52.0
Total project cost (EUR): 4958172.5
EU funding (EUR): 4958172.5
Participants: 17
Project status: CLOSED

SALSA will assess the role of small farms and small food businesses in delivering a sustainable and secure supply of affordable, nutritious and culturally adequate food. SALSA will identify the mechanisms which, at different scales, can strengthen the role of small farms in food systems and thereby support sustainable food and nutrition security (FNS). By considering a gradient of 30 reference regions in Europe and in Africa, we will obtain a differentiated understanding of the role of small farms and small food businesses in very differently structured food systems and situations. SALSA will elaborate and implement a transdisciplinary, multi-scale approach that builds on and connects relevant theoretical and analytical frameworks within a food systems approach, and that uses qualitative, consultative and quantitative methods. We will also test a new combination of data-based methods and tools (including satellite technologies) for rigorously assessing in quantitative terms the interrelationships between small farms, other small food businesses and FNS, paying particular attention to limiting and enabling factors. SALSA will use participatory methods, at regional level, and establish a more global Community of Practice and multi-stakeholder learning platform, based on FAO’s TECA online communication and learning platform. The SALSA consortium, and the joint learning and close cooperation, have both been designed with the EU - Africa dialogue in mind. Responding to the call we will unravel the complex interrelationships between small farms, small food businesses and FNS, and unfold the role played by small farms in (a) the balance between the different dimensions of sustainability, (b) maintaining more diverse production systems, (c) supporting the urban/rural balance in terms of labour and (d) in facilitating territorial development in countries facing a strong rural population growth.

Keywords: food and nutrition security,sustainability,food chains,small farms,small food businesses,food systems,transdisciplinarity,multi actor,systemic,advanced spatial analysis,policy,africa
Gender Diversity Impact – Improving research and innovation through gender diversity (GEDII)

Framework: Horizon 2020 — Science with and for Society
Programme: Promote gender equality in particular by supporting structural change in the organisation of research institutions and in the content and design of research activities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Sweden,United Kingdom,United Kingdom
Call: Impact of gender diversity on Research & Innovation (H2020-GERI-2014-1, 2014)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 999901.25
EU funding (EUR): 999901.25
Participants: 6
Project status: CLOSED

The impact of gender diversity on research productivity, quality and innovation is very unevenly evidenced. Incremental insights from gender studies, team science and research evaluation exercises do not transcend these separate areas and are therefore of restricted analytical value. This can be seen, for example, in the understanding of 'gender' as simply concerned with the numerical representation of the two sexes in most quantitative analyses. This not only factors out the gendered hierarchies and social processes that condition science in general and work group dynamics in particular, but severely hampers systematic comparisons of research performance impacts. Using innovative methods for the analysis of the diversity-research productivity relationship, Gedii will develop a reliable diversity measure that is sensitive to power, status and information sharing differentials within teams and across public & private organisations. This Gender-Diversity-Index (GDI) will thus provide a much more nuanced and realistic measure of the impact of gender diversity on research productivity, quality and innovation across countries and sectors. GDI scores will be explored in relation to a flexible set of performance indicators, including patent and bibliometric measures, combined with new indicators of social impact. Gedii's evaluation framework thus responds to the growing concern with responsible research and innovation. To address the social relevance and utility of our research, Gedii will engage stakeholders early and often: through advisory groups, virtual challenges, and theme-based innovation testimonials. By combining disparate conceptual approaches to gender diversity with an innovative assessment tool, Gedii will for the first time provide clear and comprehensive evidence for the link between gender diversity and research performance and enable research policy- and decision-makers to significantly enhance the capacity of European research.

Keywords: gender diversity,research assessment,sciencemetrics,team science,gender equality,women,science,excellence,sociometrics,cross country survey,gender diversity index
PLasmonics@Transparent cONductive oxidEs (PLaTONE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-12-01
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The capability of chemically and physically engineering the electrical and optical response of solids represents both the driving force and the consequence of the tremendous technological development of electronics, optoelectronics and plasmonics within the past century. As a most relevant example, the process—known as doping—of introducing foreign impurities in suitable hosts has led, among others, to the development of Transparent Conductive Oxides (TCOs), materials combining visible-light optical transparency with high electrical conductivity that are nowadays an irreplaceable component of solar cells and touch screens. Plasmonics and photonics, in parallel, have reached unprecedented levels of control of electromagnetic energy thanks to the possibility of fabricating and tailoring metallic nanostructures with physical dimensions down to the micro- and nano-scale for nano-antennas, perfect absorber and cloaking applications, to mention a few. One of the new challenges that researchers and engineers are facing is merging optical and electrical control in a single device for developing next-generation photovoltaic, opto-electronic devices and energy-efficient solid-state lighting. PLaTONE proposes the realization of a novel class of materials combining plasmonic resonators with TCO-based thin-film capacitors, a system envisaged in literature but not yet achieved. PLaTONE will address the fabrication and the electrical/optical characterization of these systems and exploit the mutual interaction between the plasmonic nanostructures and the voltage-controlled dielectric properties of the TCO for achieving an active optoelectronic device. PLaTONE musters up a team of highly experienced researchers from both academic and non-academic institutions to tackle the issue, and provides the candidate the ideal environment for boosting his skills and assemble a solid collaboration network for future national and international funding programs.

Keywords: hot elctrons,field effect,alzno,nanoparticles,self assembly
Nonparametric Bayes and empirical Bayes for species sampling problems: classical questions, new directions and related issues (NBEB-SSP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 982930.0
EU funding (EUR): 510430.0
Participants: 2
Project status: SIGNED

Consider a population of individuals belonging to different species with unknown proportions. Given an initial (observable) random sample from the population, how do we estimate the number of species in the population, or the probability of discovering a new species in one additional sample, or the number of hitherto unseen species that would be observed in additional unobservable samples? These are archetypal examples of a broad class of statistical problems referred to as species sampling problems (SSP), namely: statistical problems in which the objects of inference are functionals involving the unknown species proportions and/or the species frequency counts induced by observable and unobservable samples from the population. SSPs first appeared in ecology, and their importance has grown considerably in the recent years driven by challenging applications in a wide range of leading scientific disciplines, e.g., biosciences and physical sciences, engineering sciences, machine learning, theoretical computer science and information theory, etc. The objective of this project is the introduction and a thorough investigation of new nonparametric Bayes and empirical Bayes methods for SSPs. The proposed advances will include: i) addressing challenging methodological open problems in classical SSPs under the nonparametric empirical Bayes framework, which is arguably the most developed (currently most implemented by practitioners) framework do deal with classical SSPs; fully exploiting and developing the potential of tools from mathematical analysis, combinatorial probability and Bayesian nonparametric statistics to set forth a coherent modern approach to classical SSPs, and then investigating the interplay between this approach and its empirical counterpart; extending the scope of the above studies to more challenging SSPs, and classes of generalized SSPs, that have emerged recently in the fields of biosciences and physical sciences, machine learning and information theory.

Keywords: bayesian nonparametrics,empirical bayes,species sampling problems,uncertainty quantification,bayesian asymptotics,reinforcement learning,feature sampling problems,differential privacy
Functional mechanism of heparin-binding hemagglutinin adhesin from Mycobacterium tuberculosis (HADES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-07-02
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

Tuberculosis (TB) is one of the most aberrant causes of global mortality and the molecular mechanisms of its pathogenesis are not well understood. The extrapulmonary dissemination of TB involves requires a crucial virulence factor designated as heparin-binding haemaglutinin adhesin (HBHA). HBHA is a 28 kDa dimeric protein localised at the surface of the Mycobacterium tuberculosis (MTB) that binds dextran sulphate, dermatan sulphate, glycosaminoglycans and heparan-sulphate proteoglycans thus mediating the adhesion with epithelial cells and to extracellular matrix components. Despite a crucial role in the dissemination of TB, a key relevance as strong diagnostic antigen and as therapeutic target, there is currently limited understanding of the structure and mechanism of action of HBHA. The ambitious aim of this proposal is to characterise at high-resolution the mechanisms of function of HBHA in different phases of the life cycle of MTB. To achieve this ambitious target, we will carry out an integrated investigation of solution-state and solid-state NMR nuclear magnetic resonance (NMR) to acquire high-resolution data on the interaction of HBHA with membranes of MTB. The NMR experiments will be complemented with biophysical studies and mutagenesis to accurately define the relationship between structure, dynamics and function of HBHA. Our preliminary data suggest that this ambitious project comes at the most opportune time as we now have tools, materials and knowledge to resolve this important goal for biochemistry and reveal the propeties of a crucial molecule for the mechanism of extrapulmonary dissemination of TB.

Keywords: nuclear magnetic resonance,biochemistry,protein structure,membrane proteins