Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Active Suspensions with Controlled Interaction Rules (ASCIR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany,Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2023-03-31
Duration (months): 78.0
Total project cost (EUR): 2036750.0
EU funding (EUR): 1824735.24
Participants: 2
Project status: SIGNED

Self-propelling, i.e., active colloidal particles constitute a novel class of non-equilibrium systems which exhibit structural and dynamical features similar to those in assemblies of bacteria or other motile organisms. Due to their reduced complexity, they provide an intriguing chance to understand the formation of dynamical structures in non-equilibrium systems in unprecedented detail. A central question in this rapidly growing field is, how interaction-rules determine the creation of e.g. swarms or complex networks. In addition to ordinary inter particle and hydrodynamic forces, interaction-rules can be much more complex. For example, they can regulate the particle motility depending on their relative orientation, their local density or otherwise distinct particle configurations. Here, we propose an experimental approach which aims towards controlling the amplitude and direction of the particle’s motility in dense active suspensions on a single particle level. Particle-propulsion is achieved by a light-activated diffusiophoretic mechanism, where the particle motility is controlled by an incident light field. By means of an acoustic-optical modulator and a feed-back loop, we create dynamical and spatially-resolved light fields which depend on the current configuration of active particles and user-defined interaction rules. Because these rules are imposed externally and not by internal forces, this permits the experimental realization of a wide range of rules (linear, non-linear, and even non-reciprocal) in dense, two-dimensional active systems. We expect, that the experimental realization of user-defined interaction-rules largely extends our understanding how active matter can organize in dynamical structures. In addition, the perspective of enhanced control of active particles, as suggested within this proposal, will be of considerable importance for their use as autonomous micro robots which will deliver payloads in liquid environments.
Integrated Catalytic Recycling of Plastic Residues Into Added-Value Chemicals (iCAREPLAST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Austria,Germany,Netherlands,Netherlands,United Kingdom,Portugal
Call: Efficient recycling processes for plastic containing materials (IA) (H2020-NMBP-SPIRE-2018, 2018)
Start date: 2018-10-15
End date: 2023-04-14
Duration (months): 54.0
Total project cost (EUR): 8085682.5
EU funding (EUR): 6507043.25
Participants: 11
Project status: SIGNED

Approximately 70% of European plastic waste (18.5 mt/year) is not being recycled due to technical or economic reasons and are thus sent to landfill (27%) or incinerated (42%). This situation affects negatively the environment in terms of pollution and greenhouse gases emissions, as well as social perception regarding waste management, consumer’s products industry and policy makers. iCAREPLAST addresses the cost and energy-efficient recycling of a large fraction of today’s non-recyclable plastics and composites from urban waste. Heterogeneous plastic mixtures will be converted into valuable chemicals (alkylaromatic) via chemical routes comprising sequential catalytic and separation steps. This multistage process will also yield carbon char and a pure CO2 stream as products, whilst it will present improved economic sustainability, operational flexibility and lower CO2 footprint thanks to (i) the energetic valorisation of gas by-products through innovative oxycombustion units integrated with efficient heat recovery; and (ii) the use of AI predictive control and real time optimisation. iCAREPLAST aims to demonstrate (TRL-7) the whole technology for plastic waste valorisation in a pilot plant able to process >100 kg/h of plastic. Advanced upstream waste sorting, pre-treatment and pyrolysis is strongly backed by previous demonstration activities and knowhow of the consortium, with profound knowledge of waste management and recycling market. iCAREPLAST solution will enforce circular economy by substantially increasing the amount of recycled plastics to produce commodity products that can be used for virgin-quality polymers production or as raw materials for other processes in petrochemicals, fine chemicals, automotive and detergent/surfactants industries. As a result of its initial exploitation we will treat 250,000t of plastic waste which otherwise would have become landfill, converting it into 1,500t of alkylaromatics and 1,000t of aromatics.

Keywords: aromatics,catalysis,pyrolysis,plastic mix,artificial intelligence,co2 capture,membranes,recycling,urban waste
Pseudohypoxia-mediated cardiac regeneration (PhyCaR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-14
End date: 2024-02-13
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Ischemic heart disease is the main cause of death in Europe and the world, and its main manifestation is myocardial infarction (MI). The MI leads to loss of heart tissue, tissue scarring associated with fibrosis, dysfunction and heart failure. The pathophysiological basis of heart failure in humans lies in the heart's inability to regenerate. Adult cardiomyocytes (CMs) perform mitosis after MI, but their proliferation rate is extremely low for restoring normal cardiac function. During development, low levels of intrauterine oxygen promote the proliferation of CMs, which decreases postpartum due to the metabolic adaptation that implies exposure to atmospheric oxygen. Induced hypoxia in adult mammals promotes proliferation of CMs, and is required for cardiac regeneration (CR) of teleost such as zebrafish. However, the mechanisms that mediate these effects are unclear. Systemic exposure to hypoxia has been proposed as a strategy to promote CR; however, its adverse effects on other vital organs limit its clinical use. Here, we have proposed the generation of a temporary and localized hypoxia in the infarcted area of the heart. To achieve this, we will synthesize fibrin scaffolds bearing FG-4592 - an agent that mimics the effects of hypoxia (pseudohypoxia) - using bioprinting 3D. Besides, scaffolds will be loaded with CMs derived from Induced pluripotent stem cells (iPSCs-CMs), and will be implanted in MI models of pigs. Delivery of FG-4592 and iPSCs-CMs through scaffolds in the damaged myocardium would promote proliferation of resident CMs and cell turnover, respectively. Additionally, we will explore two mechanisms by which hypoxia could promote CR, remodeling of the extracellular matrix and angiogenesis mediated by angiopoietin-like 4 (Angptl-4). This project is a necessary effort to materialize the latest advances in hypoxia and CR by combining cell therapy with a cutting-edge technology in the tissue engineering field, 3D bioprinting.

Keywords: cardiac regeneration,hypoxia,pseudohypoxia,hypoxia mimetic agents,scaffolds,bioprinting 3d,induced pluripotent stem cells,cardiomyocytes,angiopoietin like 4,ecm remodeling,angiogenesis
Hopf algebroids in quantum differential geometry (HADG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

While cohomology theories of various kinds are known on algebras, here we explore the much harder problem of what is the ‘homotopy’ of an algebra as a geometric object? For example, when is an algebra ‘simply connected’? The project will make sense of this notion using a constructive approach to noncommutative differential geometry in which the possibly noncommutative algebra A is extended to a graded algebra of ‘differential forms’. The Experienced Researcher will first develop and study a recent proposal of a Hopf algebroid D_A of ‘differential operators’ associated to this data, the existence of which is implied by the More-Eilenberg theorem applied to the category of bimodules on A equipped with flat bimodule connections. In the classical case of functions on a smooth manifold, this would be a version of the path groupoid and Morita equivalent to π_1. He will then relate it to a proposed new construction of a universal (co)measuring bialgebra adapted to the differential graded case as a generalised ‘diffeomorphism group’ and to a proposed new notion of differential ‘character variety’ defined by each Hopf algebra H as the moduli of flat connections up to equivalence on quantum principal bundles over A with fibre H. Classically, the holonomy associated to a flat connection identifies this as maps from π_1 to the fibre group modulo conjugation. Using these ingredients, the further aim will be to arrive at a quantum differential geometric picture of the Turaev-Viro invariant of 3-manifolds and generalise it to a suitable class of differential algebras A. The project will also study an analogue of D_A in Connes’ spectral triple approach to noncommutative geometry based on an axiomatic ‘Dirac operator’, explore generalisations at the level of 2-categories and Hopf monads and look for applications to algebraic models of quantum gravity, where both diffeomorphism invariance and ‘loops’ are expected to play a fundamental role.

Keywords: hopf algebras,quantum groups,hopf galois extension,quantum riemannian geometry,principal bundle,fundamental group,d module,differential operators
The Enigma of the Hyksos (Hyksos Enigma)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Austria,United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 2446819.0
EU funding (EUR): 1957506.5
Participants: 2
Project status: CLOSED

The Hyksos (Greek rendering of the Egyptian title “rulers of the foreign countries”) were a dynasty of foreign rulers of Egypt between c.1640 and 1530 BC. Some modern researchers, following the ancient historian Flavius Josephus (1st cent. AD) thought they were ancestors of the early Israelites, others suggested that their appearance should be tied to the Hurrian expansion to the Levant. Most scholars today think, according to the onomastic data, that they were western Semites. Their geographical origin in the Levant, their seizure of power and their role in history, remains, however, an enigma, as the period is poorly represented in texts. Nevertheless the Hyksos phenomenon has thus far mainly been studied by text-based Egyptology. In the last decades, however, excavations at T. el-Dab‘a, T. el-Rotaba, T. el Maskhuta and other places in the eastern Delta have produced an enormous wealth of new data such as urban settlements, palaces, tombs, temples, offering remains, besides enormous quantities of material culture and physical remains which can be attributed to the carriers of the Hyksos rule and their predecessors. These materials, left thus far largely aside in the historical discussion, can be utilised as first class historical sources. The envisaged investigations will be conducted in 8 interrelated research tracks, incorporating an array of archaeological, historical, theoretical and analytical sciences. The aim is to reveal in a holistic approach the origin, the dialogue with and the impact of western Asiatic people on culture of the host country and finally their heritage. They played a much greater role in the history of the Old World than envisaged and pushed Egypt into the focus of what happened in the Near East in the 2nd millennium BC. This innovative exploration of the Hyksos phenomenon has the potential to write a new chapter in the history of this salient region and offer a model.

Keywords: egyptology,hyksos,migration,acculturation,crisis,diachronic studies,cultural interference studies
Statistical Learning for Earth Observation Data Analysis. (SEDAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1716954.0
EU funding (EUR): 1716954.0
Participants: 1
Project status: CLOSED

SEDAL is an interdisciplinary project that aims to develop novel statistical learning methods to analyze Earth Observation (EO) satellite data. In the last decade, machine learning models have helped to monitor land, oceans, and atmosphere through the analysis and estimation of climate and biophysical parameters. Current approaches, however, cannot deal efficiently with the particular characteristics of remote sensing data. In the coming few years, this problem will largely increase: several satellite missions, such as the operational EU Copernicus Sentinels, will be launched, and we will face the urgent need to process and understand huge amounts of complex, heterogeneous, multisource, and structured data to monitor the rapid changes already occurring in our Planet. SEDAL aims to develop the next generation of statistical inference methods for EO data analysis. We will develop advanced regression methods to improve efficiency, prediction accuracy and uncertainties, encode physical knowledge about the problem, and attain self-explanatory models learned from empirical data. Even more importantly, we will learn graphical causal models to explain the potentially complex interactions between key observed variables, and discover hidden essential drivers and confounding factors. This project will thus aboard the fundamental problem of moving from correlation to dependence and then to causation through EO data analysis. The theoretical developments will be guided by the challenging problems of estimating biophysical parameters and learning causal relations at both local and global planetary scales. The long-term vision of SEDAL is tied to open new frontiers and foster research towards algorithms capable of discovering knowledge from EO data, a stepping stone before the more ambitious far-end goal of machine reasoning of anthropogenic climate change.

Keywords: machine learning,regression,graphical models,causal inference,earth observation,remote sensing data processing
Enabling the large-scale deployment of Facial Recognition in banking security (FACCESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Spain
Call: Engaging SMEs in security research and development (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-12-01
End date: 2018-11-30
Duration (months): 24.0
Total project cost (EUR): 2418000.0
EU funding (EUR): 1692600.0
Participants: 1
Project status: CLOSED

FacePhi is a company founded in 2006 specialized in the development and commercialization of advanced Face Recognition Software solutions. There is a strong demand in the banking industry for secure biometric applications. In fact, in May 2014 the European Central Bank (ECB) published a list of recommendations for increased banking security and biometrics was included as one of the most secure authentication methods. Concerns about banking security have always existed, but it has been after the breakthrough of online and mobile banking when bank fraud has become major issue to address with urgency. Currently, banking authentication is typically done by using 4-6 digits PIN codes. This form of authentication provides an extremely low security, especially in online banking where cybercriminals can hack this PIN code in a matter of seconds. As a result, the total value of fraudulent transactions is rapidly increasing year by year, being now estimated at €1.44 billion solely in Europe. In this scenario, biometrics holds great promise to become a reference banking authentication method in a near future. However, despite the clear opportunity there are still some barriers preventing the banking biometrics breakthrough, at least on a large scale. FacePhi has developed a face recognition technology, specifically designed to overcome the current barriers preventing the large scale deployment of banking biometrics. Now, in the FACCESS Phase 2 project we seek demonstrating our facial recognition technology can actually unleash the large scale deployment of banking biometrics by the implementation of our product in the mobile/online platforms of 6 international banking institutions.

Keywords: biometrics,banking security
INfraStructure in Proton International REsearch (INSPIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Italy,Belgium,Lithuania,Belgium,Sweden,Switzerland,Poland,France,Czechia,Netherlands,Denmark,United Kingdom
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2017-1-two-stage, 2017)
Start date: 2018-03-01
End date: 2022-12-31
Duration (months): 58.0
Total project cost (EUR): 4999867.0
EU funding (EUR): 4999867.0
Participants: 18
Project status: SIGNED

Proton beam therapy (PBT) is a radical new type of advanced radiotherapy, capable of delivering and conforming a targeted dose of radiation to the tumour while causing minimal damage to the surrounding healthy tissue. In the past 5 years there has been a huge investment in high energy PBT across Europe and eleven member states now either have PBT in operation or are developing this capability. In addition, the two largest manufactures of PBT equipment have based their manufacturing in Europe. This integrating activity INSPIRE, aims to link these clinical PBT centres in eleven different countries together with two associated centres in USA. It also brings in two of the worlds largest manufacturers of PBT equipment and an SME. The trans-national access in INSPIRE will provide European researchers with access to “state of the art” research capabilities employing proton beams at clinical energies. INSPIRE represents an integrating activity across Europe in a multi-disciplinary field that is growing exponentially. Through its Networking, Transnational Access and Joint Research Activities, INSPIRE seeks to provide the “state of the art” capabilities that are needed to address the key challenges in this rapidly developing field. INSPIRE has at its heart the principles of responsible research and innovation and will communicate its research and give access to its databases and software through an Open Access Gateway. INSPIRE will contain a pipeline of innovation through its Innovation Gateway, to accelerate research for patient and commercial benefit. INSPIRE will provide its researchers with an unrivalled research and training and opportunities to “discipline hop” into the industrial, clinical or industrial environment. INSPIRE integrates activities across Europe in this rapidly growing area and offers European researchers unrivalled access to state of the art research capabilities in an area where there has already been significant government investment.

Keywords: proton beam therapy,integrating activity,networking,transnational access,joint research activities,radiobiology,mathematical modeling,dosimetry,patient selection databases,innovation
Characterization and monitoring of vigilance fluctuation in disorders of consciousness (ADOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-11-10
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

This prospective exploratory study will aim at characterizing vigilance fluctuation in patients with disorders of consciousness (as defined by a change in diurnal behavioral response over time) using neurophysiological parameters. We based this project on the assumption that changes at the Coma Recovery Scale-Revised scores (i.e., behavioral responsiveness) will be associated with a change in ocular measures and EEG complexity, suggesting that some of these parameters could be used for monitoring vigilance in this population. We expect that this fluctuation will be particularly marked in patients with a minimally conscious state as compared with patients in an unresponsive wakefulness syndrome who will display a more stable pattern of response over the two days. This project aims to better understand the course of vigilance fluctuation in DOC and to develop an objective tool based on biomarkers that could be used at bedside to determine the best periods to assess and treat these patients.

Keywords: vigilance,behavioral assessment,consciousness,electroencephalography,eye response