Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Prevention of SARS-CoV-2 infection through development and clinical testing of a novel Virus Like Particle (VLP) vaccine (Prevent-nCoV)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Netherlands,Netherlands,Netherlands,Denmark,Denmark
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-04-01
End date: 2022-06-30
Duration (months): 27.0
Total project cost (EUR): 3399387.5
EU funding (EUR): 2728340.0
Participants: 9
Project status: CLOSED

Our aim is to perform pre-clinical and clinical evaluation of a potential Wuhan Coronavirus vaccine candidate. The vaccine will be based on Virus-Like Particle (VLP) display of the SARS-CoV-2 Spike protein antigen. AdaptVac's VLP display technology has been shown to significantly improve vaccine immunogenicity, longevity and efficacy, for a wide range of viral and parasite diseases in pre-clinical studies (including flu and malaria). A unique feature of the technology is its two-component approach. The VLP is generic to all vaccines, and produced at >1g/L yields using E. coli. The disease antigen is produced in any expression system, allowing the most challenging antigens to be successfully produced. The VLP and antigen is then simply mixed, and a spontaneous, irreversible, conjugation occurs under physiological conditions. This results in site-specific, directional, and high-density display of the antigen on the VLP surface. The antigen will be produced using ExpreS2ion's Drosophila S2 insect cells based on the trimetric spike antigen. Furthermore, E. coli and baculovirus will be tested for Spike protein variants. The vaccine candidates will be tested pre-clinically using in vitro viral neutralization assays and possibly animal challenge models as they become available at LUMC. ExpreS2ion will develop the production processes and transfer these for GMP manufacture of the VLP and vaccine antigen, outsourced, to AGC Biologics. Finally, a phase I/IIa study will be performed at Radboud University Medical Center in the Netherlands. A surrogate marker of protection will be established by showing protection in animal models using passive transfer of participant sera, or by in vitro SARS-CoV-2 viral neutralization. This project is focused on delivering a scalable vaccine, ready for testing in the field, which has been shown to be safe in humans and effective in in vitro or animal models.

Keywords: vaccine,prevention,virus like particle,spike protein,2019 ncov
Experimental co-Design Approaches: Investigating possibilities for creating networks of resilient citizens and civic actions of urban resilience through hybrid platforms (EcoDA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

EcoDA investigates methods for co-designing platforms that can stimulate collective civic actions of urban resilience and enhance the capacities of urban residents to become resilient. The project focuses on food practices as case studies of resilient actions and tests a hybrid platform in three European cities – London, Paris and Bucharest. The research has three main objectives: 1) to examine the social, cultural, political and technological contexts for urban resilience, and map existing civic initiatives around resilient food practices in the three selected cities; 2) to co-design, prototype, test and refine open source digital platforms that could enable such civic initiatives to take place and/or expand, and enhance resilience capacities for citizens; and 3) to evaluate the capacity of these co-designed platforms to generate forms of public participation and urban governance that can stimulate actions of urban resilience. To address these objectives, the research will be carried out through design practice, through secondments within three professional practices working in the area of urban resilience, in the three elected cities. The methodology includes traditional qualitative methods (e.g., interviews), participatory action research, co-design experiments and collaborative workshops. The innovative and original aspects of EcoDA offer significant value in the context of the Horizon 2020 EU Programme, by addressing areas of special focus (e.g., sustainable food security and waste management) and key objectives (e.g. boosting industry engagement and supporting innovation). Moreover, the practice-based research approach, the open-source nature of the platform and the provision of the ‘metadata’ needed to enable the platform, will facilitate the up-scaling and up-taking of EcoDA’s outcomes in various cities across Europe and possibly further away, thus enabling collaborations beyond the term of the project.

Keywords: collaborative technology,open source,food,resilience,public participation,governance,civic action,co design,co production,experimentation,prototyping
Student networks leading the struggle for universities free of sexual violence: mechanisms to support survivors, inspiring institutional changes for violence prevention (UniswithHeart)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: SIGNED

The problem of sexual violence in universities and institutions is getting international attention. In this watershed moment, European Student Networks of Support (SNS) are progressively acting to prevent and face this problem. This project aims (1) to study in which ways do social movements struggle to eradicate sexual violence to contribute to the creation of networks of support in higher education; inquiring on social actors engaged, resistances faced and overall, how are contexts of zero tolerance in which victims feel empowered to speak up shaped. Power structures and complicities are often limiting student movements from effective organizing in preventing harassment. Drawing from this, the project pretends (2) to uncover effective strategies and mechanisms of SNS and the movement against sexual violence in universities, focusing on how it successfully performs and got to be so widely recognized. The emergence of these social movements count on the support of active bystanders, including scholars who develop research and action for and with the public, committed with improving the existing civil society worldwide. In this line, (3) the role of public sociology in promoting SNS is also explored. Their empowerment is influencing not only academic policies against sexual violence but also political changes, legislations. Thus, impact is expected on three realms: on personal and professional success of direct and second order victims of sexual harassment in academia; on effective university policies; as well as on regulations beyond academic institutions. The gap to be filled (in Europe) focuses on the emerging and articulation of Student Networks of Support illustrating the knowledge of their development and repercussion while successfully influencing administrations, political spheres and legislations, making the EU leader not only in social science research but also in contributing to foster pioneer regulations against gender-based violence.

Keywords: sexual violence,social movements,student networks,violence prevention,university
New insights into the genetic mechanisms underlying behavioural variation in wild marine fish (WildFishGenes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-16
End date: 2024-04-14
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Humans depend on great measure on the welfare of marine ecosystems, not only from the retribution obtained directly from resource harvesting but also from the benefits derived from healthy ecosystems (i.e. quality of natural resources, biodiversity maintenance, and ecosystem resilience to anthropogenic challenges). Traditionally, management efforts to preserve marine resources only contemplated morphological traits of the individuals (e.g. body size). However, more evidence is piling up on the importance of behaviour on biodiversity conservation. Traits such as exploration, boldness, and activity have a strong impact on the individual`s reproductive success, thus determining species survival. As other phenotypical traits, fish behaviour is determined in great measure by its genetic basis. In this project, we propose studying the genetic mechanisms underlying fish behavioural types. We will use a unique dataset based on state-of-the-art fish-tracking data that provides long-term behavioural data in situ for hundreds of free-living fish at unprecedented spatio-temporal resolution. We will complement the behavioural data set with advanced genetic and genomic techniques to find phenotype-genotype associations by: i) studying the sequence variants of candidate genes, ii) studying the location and abundance of target proteins in fish brain structures, iii) obtaining multiple brain transcriptomes from individuals showing distinct behavioural types. The multidisciplinary nature of the project, combining novel behavioural data collection with next generation genomic techniques, will provide a broad overview of the molecular basis of behavioural characterization. The proposed activities will open a new line of research in behavioural molecular ecology unprecedented in marine ecosystems. Our results will provide insight into the molecular basis of behaviour in marine fish, thus leading to a qualitative jump forward in fisheries management and behavioural biology.

Keywords: acoustic tracking,fish genetics,fish movement,fisheries induced evolution,fisheries management,marine protected areas,transcriptomics
Land Use and Resource Management at the Agricultural - Forest Frontier (LARMAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-02
End date: 2019-05-01
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In this fellowship, I aim to explore the trade-off and synergies between conservation and commodity production through an Ecosystem Services (ES) lens in order to determine how sustainable land use practices can be created and strengthened over time, and to extend knowledge on ES within broader land use, and natural capital research. I will carry out targeted fieldwork to investigate the following research lines: 1) how ES are defined and conceptualised as commodities and how these relate to more established ‘land’ commodities. This research line will include ES to humans, but also factors causing ecosystem change that can affect the long-term resilience of such ecosystems, by examining selected drivers of land use change. Research line 2) relates to the impact of appropriation of land for commodities (e.g., the demand for cash crops such as soy, biofuels and land used for livestock production or conservation) on local communities, and the global economy and policies that may drive (the current or any) 'land grabs'. I will take into account the discourse, practices and social relationships around land use that are currently unfolding within the 'realpolitik' of a studied region. These phenomena are highly debated yet remain poorly understood and should become key analytical domains for academics insofar that they are related to broader processes of economic globalization, biodiversity loss and climate change. The findings will be complementary to climate change mitigation efforts and feed into policy processes around securing food security, with an objective to not only contribute to sustainable land use practices but to promote the livelihood opportunities and environmental quality of (often) marginalized communities living in and around contested land.

Keywords: agricultural commodities,land use change,payments for ecosystem services
Test, Predict, and Improve Musical Scene Perception of Hearing-Impaired Listeners (TIMPANI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

In both speech and music perception, the auditory system decomposes sounds that overlap in time and frequency into distinct perceptual events and streams, which is referred to as auditory scene analysis (ASA). Hearing-impaired listeners suffer from severely compromised ASA, as illustrated by their immense difficulties to understand speech in noisy environments. Although the central role of ASA in shaping the experience of music is widely acknowledged—perceptually organizing sounds from multiple instruments or voices into melody and accompaniment, for instance—the role of hearing loss in musical scene perception remains largely unexplored. At the same time, hearing aids are typically designed for speech perception, not for music perception. Adopting a transdisciplinary approach that employs methods from music perception, auditory modelling, and signal processing, this Marie Skłodowska-Curie Action aims to Test, Predict, and Improve Musical Scene Perception of Hearing-Impaired Listeners (TIMPANI). Firstly, a series of music perception tasks will be designed to assess the effects of hearing loss on musical scene perception abilities. Secondly, an auditory model will be developed in order to predict normal and hearing-impaired listeners’ performance in ASA tasks. Finally, algorithms for scene-aware music mixing will be developed for improved music perception of hearing aid users. This research is timely and addresses the H2020 challenges to improve demographic change and wellbeing in European societies: The rise of hearing loss calls for scientific and technological breakthroughs in order to include hearing-impaired individuals in the cultural resource of music listening and making.

Keywords: music perception,hearing loss,auditory scene analysis
European Proteomics Infrastructure Consortium providing Access (EPIC-XS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Estonia,Austria,Italy,Germany,Spain,Spain,Switzerland,Norway,Sweden,Belgium,Greece,France,Czechia,Czechia,Netherlands,Denmark,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2018-1, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 9986185.75
EU funding (EUR): 9986185.75
Participants: 20
Project status: SIGNED

In life sciences research, proteomics technologies promise to be even more revolutionary than genomics for understanding the molecular mechanisms of complex biological systems and their (mal-)functions in health and disease. As a result, there is a strongly growing need for the integration of proteomic technologies into world-class life sciences research programs in medicine, agriculture, food, biotechnology, and materials. The European Proteomics Infrastructure Consortium providing Access (EPIC-XS) brings together a consortium of world-leading, highly innovative European proteomics facilities with the shared goal of supporting excellent life sciences research in Europe. This will be achieved by providing access to cutting-edge proteomics facilities, and by developing and implementing novel mass spectrometry based proteomics and bioinformatics approaches to shape the future life sciences research in Europe. The Transnational Access in EPIC-XS consists of around 2400 days of access to state-of-the-art proteomics facilities, corresponding to around 150 user projects, which will be evaluated by an independent review panel to ensure excellence, and to match users with the best facility for their challenging research questions. The cutting-edge Joint Research Activities in EPIC-XS are built on the extremely strong innovation track record of the consortium members, and will address bottlenecks in, and develop novel approaches for, future-oriented efforts in computational and structural proteomics, analysis of higher-order proteome organization, multi-omics integration, and translational/clinical proteomics and personalized/precision medicine. EPIC-XS will provide users with unrivalled access to world-leading facilities and expertise, while simultaneously extending Europe’s leading international role in the. EPIC-XS meets the widespread current demands for user access, addresses present bottlenecks in the field and will open up entirely new perspectives in proteomics.

Keywords: proteins,proteomics,bioinformatics,structural proteomics,translational proteomics,mass spectrometry
Multidisciplinary Training of Young Researchers in Novel Implantable Bio-inspired sensors (BioInspireSensing)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Spain,Switzerland,Poland,Belgium,France,France,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 2856013.2
EU funding (EUR): 2856013.2
Participants: 9
Project status: SIGNED

The purpose of this trans-national training network is to train PhD students, in investigating, building, and producing a new generation of bioinspired implantable sensors of pressure, temperature and acidity. New devices will be made of complex hybrid materials, composed of natural molecules and synthetic biopolymers, with the additional properties of being fully biocompatible and bioresorbable, unlike most of existing implantable sensors; anticipating thus, a new generation of sensors that would not require posterior surgical extraction. BioInspireSensing project will apply the state-of-the-art in ion channel proteins, cell membrane transport, unilamellar vesicles, tethered planar lipid bilayers, synthetic biochemistry, and biodegradable and flexible conducting polymers to obtain the novel sensors. It will take advantage of a unique multi-sectorial and multi-field environment to further teach early stage researchers (ESR) to apply the gained knowledge in analysing and designing/engineering complex biological nanosensors of medical importance. BioInspireSensing cutting-edge training will provide the ESRs not only with the scientific and technical skills but also with the transferable skills necessary for thriving careers, by a unique combination of research training, industry placements, as well as courses and workshops on scientific and complementary soft skills. ESRs training will take place both at world-leading European academic institutions and companies, forming strong interdisciplinary relations between technical sciences and industry (key to translate the results of basic research into medical applications). These relations are implemented through direct employment of the ESRs and through inter-sectoral secondments. The BioInspireSensing project will thus create opportunities for the ESR’s career mobility and their knowledge transfer to the European Community, increasing their employability in the biotechnology and med device industries and health economy.

Keywords: bioresorbible materials,ion channel,mutagenesis,planar lipid bilayers,biodegradable materials,green electronics
Launching the Maritime Copernicus Enablement Platform (MCEP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Portugal
Call: SME Instrument (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Copernicus, the enormous Earth Observation European programme based on satellites and intended to provide data for further uptake and use for companies, generates high volumes of information not easy to process and exploit. Anyone interested in using Copernicus data needs to pre-process and store the information in a high performance and big data repository for further querying. Eixo Digital (ED) is a Portuguese SME active in the areas of IT consulting and software development, focused and with proven experience on the development of telecommunication solutions for the mobile satellite communications market. ED has developed MCEP – Maritime Copernicus Enablement Platform, based in open-source technologies, in order to offer to developers an easy way to exploit this data by means of an open API. With this solution, Copernicus data is available to everyone – from the single developer to the large company- without having to set up the entire infrastructure. MCEP will boost the use of Copernicus data by providing a consistent, simplified and scalable access to this powerful resource. The MCEP solution will provide economic benefits to users by allowing them to create added-value services on top of Copernicus data. The platform can easily be expanded to other sectors beyond the marine environment granting a wider use of Copernicus downstream applications. MCEP is based on the Metry Framework, which serves as the storage backbone, already developed by us as part of the ESA Space Programme. Our overall objective in this essential project for ED is the broad exploitation of the proposed platform. In Phase 1, our specific objective is to prepare a clear Feasibility study and Business plan on how to reach and exploit this extraordinary platform for different target groups, which might imply different business models, and different market strategies. In Phase 2, our objective is to implement the actual work necessary to reach the goals outlined in the Phase 1 Feasibility Stu

Keywords: copernicus,satellite communications,marine environment,sentinel satellites,ocean,myocean,myocean2,earth observation applications,space,downstream application,open source,technologies