Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Online Hate against European Women Leaders: a Corpus-Assisted Multimodal Critical Analysis (WONT-HATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Today’s digital media have a strong potential to strengthen women’s participation in political and institutional processes, but have also opened up new channels for gendered attacks against women advancing their way in the public sphere. WONT-HATE investigates phenomena of online misogyny, such as gender-based hate speech, rape threats and image-based sexual harassment, against highly visible, political and institutional figures in Europe. More specifically, WONT-HATE maps the multimodal discursive and rhetorical strategies of online hate against women in politics across four different linguistic landscapes and political cultures in Europe, namely Italy, Spain, France and the U.K. WONT-HATE is characterized by a multimodal critical discursive approach to cyberhate, entailing a quantitative and qualitative investigation of a corpus of Youtube videos and relative user-generated comments. WONT-HATE is to contribute to the current debate on the use of social media data for social research, providing new critical theoretical perspectives as well as a transdisciplinary methodology for data selection and collection and for the contextualization of the new dynamics of digital interaction. Two secondments, at the University of Vienna and Newcastle University, further contribute to establishing a dialogue on cutting-edge social media approaches across Europe. WONT-HATE is also to yield an open access database of online misogyny speech, encompassing its lexico-syntactic and discursive features in Italian, Spanish, French and English, to foster academic research and the advancement of software solutions to the issue. Exploring discourse as social practice, and refusing to treat the ‘online’ and the ‘offline’ as separate and independent realms, WONT-HATE tackles timely issues of digital security, gender-based violence and gender equality, in line with the gender-related objectives of the Horizon 2020 Programme and the EU Strategic Engagement for Gender Equality 2016-2019.

Keywords: women politicians,gender discrimination,gender equality,online hate,online misogyny,youtube,social media studies,computer mediated communication,critical discourse studies,multimodality
Urban Observatory for Multi-participatory Enhancement of Health and Wellbeing (URBANOME)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Spain,Cyprus,Belgium,Greece,Slovenia,Greece,France,Denmark,United Kingdom
Call: Innovative actions for improving urban health and wellbeing - addressing environment, climate and socioeconomic factors (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 4974015.0
EU funding (EUR): 4974015.0
Participants: 16
Project status: SIGNED

URBANOME aims at building a common EU Framework for evaluating comprehensively multi-sector policies in urban settings supporting the “Health in all Policies” approach of WHO. In this light the overall objective of URBANOME is to promote urban health, wellbeing and liveability, through systematically integrating health concerns in urban policies and the activities of urban citizens, on the basis of detailed and comprehensive evidence on environmental health determinants, the spatial distribution of these in the city, and the social distribution of their impact among different population groups, accounting for different life styles and behaviours. Integration of health concerns, environmental stressors and social equality in public and private activities help alleviate a wide range of contemporary urban challenges, specifically social cohesion and health inequality, and promote the transition of European cities to sustainable, climate proof, smart and inclusive urban economies. URBANOME brings together the complete set of environmental, social, and functional features of a city in an integrative analytical framework that would facilitate the identification of the main determinants of urban health and wellbeing and support co-creation and testing of policies and precision interventions designed to improve urban health and wellbeing through Urban Living Labs. The URBANOME approach will be applied through pilots built by the Urban Living Labs in Aarhus, Athens, Aberdeen, Madrid, Milan, Ljubljana, Stuttgart, Paris and Thessaloniki tackling various levels of environmental exposures, age-dependent susceptibility windows, inter-individual variability, gender differentiation of exposure, and socio-economic disparities. These will allow us to draw conclusions regarding the determinants of urban health and wellbeing that will be translated into evidence–based policy recommendations considering socio-economic and environmental factors leading to urban health inequalities. URBANOME is part of the European Cluster on Urban Health which includes other research projects funded in the frame of the same call.

Keywords: wellbeing,urban physical and mental health,inequalities,social cohesion,living labs,citizen science,exposome,participatory governance,environmental stressors,nature based solutions
Unravelling the secretion machinery for virulence factors in apicomplexan parasites (KissAndSpitRhoptry)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 2496210.0
EU funding (EUR): 2496210.0
Participants: 1
Project status: SIGNED

Apicomplexan are obligatory intracellular parasites. The ability of these parasites (Plasmodium, Toxoplasma) to cause disease depends on the coordinated secretion of specialized secretory organelles. The rhoptries are particularly important, because they act as the apicomplexan equivalent of bacterial secretion systems. They inject parasite proteins directly in the cytoplasm of host cells not only for invasion but also to hijack host functions crucial to establish and maintain infection. However, in contrast to bacteria where the secretion machinery has been resolved to atomic detail, how eukaryotic parasites secrete and inject rhoptry effectors into cells is an enigma. This proposal aims to dissect the mechanistic steps and the molecular components that assemble the rhoptry secretion machine. Our aims are: 1- To explore the mechanisms that trigger rhoptry exocytosis upon binding of the parasite to the host cell. 2- To provide insights into fusion machinery of rhoptry with the parasite plasma membrane. Our model is based on the discovery that free-living Ciliates and intracellular Apicomplexa share an evolutionarily conserved blueprint for their fusion mechanism. 3- To test and expand our hypothesis that rhoptries deliver their content through a transient pore formed into the host cell membrane. We will employ powerful experimental systems in Toxoplasma, Plasmodium and the Ciliate Tetrahymena, taking full advantage of the relative strength of each model. This comprehensive project will bring together comparative genomics, targeted and global genetics, biochemistry, high resolution imaging and electrophysiology. This project answers a question of fundamental biological importance. How can a parasite sense the host cell and inject virulence factors to attain control? Understanding this mechanism will guide future efforts to disrupt parasite infection and will contribute to broader understanding of fascinating questions of membrane fusion and export processes.

Keywords: apicomplexa,toxoplasma,plasmodium,secretory organelle,rhoptry,exocytosis,export,virulence factors
Unique Biomaterial-Drug Solution for Multifunctional Central Venous Catheters (UNICAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Israel,Norway,Denmark,Portugal
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 207000.0
EU funding (EUR): 207000.0
Participants: 4
Project status: CLOSED

Central venous catheters (CVCs) play a critical role in healthcare and few medical devices are more important and widespread in modern medicine. Catheter-related bloodstream infection (CRBSI) is the most common life-threatening complication of CVCs. Reducing the risk of CRBSI among patients would save costs, reduce length of stay and improve mortality and morbidity. The major challenge of UNICAT is thus to develop a new CVC solution to prevent infection and thrombosis. The project partners will introduce a whole new way of thinking by introducing a disruptive approach which is more than just a coating of devices. A new material will, for the first time, combine ultra-biocompatibility with chemical resistance and desired mechanical properties, to effectively prevent adverse host response, inflammation and infection. A major problem in biomaterials science is that bioresistant materials are inevitably also chemically inert and hence highly difficult to manipulate by traditional wet chemistry. If manipulation (e.g. coating) is achieved, the solution is often unstable and fragile. UNICAT will address this problem by combining two materials using a novel method based on super critical CO2-chemistry. It will result in a hybrid material which is stably formed and combines the best properties of two or more materials. The success criterion is to exceed performance of coatings by producing the first fully biocompatible material to be used as sole robust bulk material of vascular access lines. UNICAT is an international and inter-sector collaborative project comprising R&D activities and secondments between the SME BioModics (BM), the University of Minho (UMinho), the Bar-Ilan University (BIU) and the Simula Research Laboratory (Simula). The consortium has identified the RISE programme as a suitable vehicle for overcoming the identified major challenges and for bridging the knowledge gap, while helping to overcome the financial, technological and intersectoral barriers.

Keywords: hybrid materials,nano particles,medical devices,antibiotics
Diagnostic Test For The Differential Diagnosis of Bipolar Disorder and Major Depressive Disorder (DDBSD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-11-30
Duration (months): 9.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Neuropsychiatric disorders contribute 13% to the global burden of disease and cost the European economy an estimated 789bn EUR a year. PsyOmics is a Cambridge-based biotechnology start-up focused on reducing this burden by providing scientifically-validated solutions that improve the prevention, diagnosis and treatment of psychiatric disorders. This project relates to the first clinical diagnostic that we intend to bring to market, a test to improve the diagnosis of bipolar disorder and major depressive disorder. It is estimated that 33.4m people within the WHO European region suffer from major depression each year, and around 7m suffer from bipolar disorder. The separation of these two groups for appropriate treatment is very challenging because patients with an underlying bipolar disorder typically present with depressive symptoms that are indistinguishable from those of MDD. The result is that around 40% of all patients with an underlying bipolar disorder are initially misdiagnosed with depression and prescribed antidepressants, rather than mood stabiliser treatments. On average it takes over 7.5 years for the correct diagnosis to be reached. There is no evidence to suggest that antidepressant monotherapies are effective in treating bipolar disorder and furthermore they are known to lead to an increased risk of anti-depressant induced mania, rapid cycling and suicide attempts among these patients, all of which lead to an increased rate of hospitalisation and healthcare costs. Our clinical diagnostic will reduce this level of misdiagnosis by enabling GPs and Psychiatrists to efficiently identify those that have an underlying bipolar disorder amongst those that present with depressive symptoms.

Keywords: bipolar disorder
Exploitation of Glycosylation Signatures for Precision Medicine (GlySign)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Croatia,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-10-01
End date: 2020-09-30
Duration (months): 48.0
Total project cost (EUR): 1552846.32
EU funding (EUR): 1552846.32
Participants: 7
Project status: CLOSED

GlySign is a research training network for the translation of glycomic clinical biomarkers for Precision Medicine (PM). Complex, distinctive changes occur in the glycomics profiles or - Glycan Signatures - of human glycoproteins during progression of many chronic diseases including cancer and inflammatory conditions. The three beneficiaries of the GlySign Consortium have been instrumental in contributing to knowledge in this field through development of glycomics technology and discovery of clinically important novel glycan biomarkers in a variety of diseases. Glycan signatures have great potential for adding useful diagnostic and prognostic information in PM. However, advancement of this field is slow because (a) glycans have immense structural complexity resulting in major technical challenges for their analysis and (b) there is a lack of experts with required glycoanalytical skills. GlySign will address this gap by training six young scientists within an innovative training-by-research programme with high industrial-academic mobility to eventually push forward the translation of novel glycomics-based diagnostic tools into clinical practice. This will be achieved by further developing a range of selective and sensitive glycomics technologies for the analysis of samples from patients and healthy controls in close collaboration between industry/academia as well as clinical chemists and clinicians who will be the end users of GlySign’s final products. To this end, we will focus the training on clinical glycomics applied to four model diseases implicating changes in the glycosylation of circulating proteins specific to disease progression or subtype, i.e. diabetes, prostate cancer, fetal and neonatal alloimmune thrombocytopenia and rheumatoid arthritis. Due to its strong industrial and translational focus, GlySign will, moreover, fill a current gap in the market by establishing new in vitro diagnostic platforms for clinical exploitation of glycomic biomarkers for PM.

Keywords: clinical chemistry
Innovation Internationalisation services by BENE 2015-2016 – I²BENE 2015-2016 (I2 BENE 2015-2016)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Belgium
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 83971.25
EU funding (EUR): 67177.0
Participants: 3
Project status: CLOSED

The project aims at offering specific services to 2 different groups of SMEs based in the Brussels Capital Region: the SME Instrument beneficiaries and the SMEs having a high potential for growth and internationalisation by the enhancement of their innovation management capacity. These services will be an integral part of Enterprise Europe Brussels services. Although for the SME Instrument beneficiaries, the proposer depends on the number of successful SMEs granted, a funnel approach will be adopted for both SMEs Groups in order to have an upstream estimation and selection of the SME potential existing in the region. This funnel and selective approach will also take into consideration the permeable frontiers which divide one SME group from the other, in light of the innovation needs and capacities at a given time of the SME lifecycle. The service provision for Group2 will be ensured via a structured process of SMEs pre-selection, set up according to a pre-defined methodology which relies on ad-hoc tools and processes, designed with the aim to select only those SMEs with the capacity, clear intent and ambition to benefit from the innovation management assessment. The pre-selection tool is based on 8 criteria: each of them has been attributed a weight according to its importance. In function of the score obtained in these different areas, the SME will be selected (or not) to benefit from the innovation management capacity assessment through the Imp³rove methodology. The I²BENE 2015-2016 proposal addresses the obstacles which hinder Brussels-based SMEs from being more competitive, from growing and creating new jobs, thus having a real impact in the regional economy, and establishing a link between the research development process and the uptake of innovative products by SMEs. The identified obstacles or barriers are mainly linked to the difficulty SMEs have got in bringing their R&D efforts to the market and this with a sound exploitation strategy

Keywords: innovation,internationalisation,sme instrument,management capacity,enhancement,een services
Analytic Loop Amplitudes from Numerics and Ansatz (LoopAnsatz)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

The Standard Model of Particle Physics is impressively consistent with the experimental measurements at the Large Hadron Collider at CERN, Geneva. In the coming years, with increased experimental statistics, precision will rise even further, allowing a unique opportunity to uncover new physics. A necessary component of this pursuit is a set of theoretical predictions made at the per cent level for a broad range of observables. In the past decade, previously unthinkable availability of precision predictions incorporating the leading quantum corrections has been made possible by technological leaps. Nevertheless, to match the discovery potential of the LHC in the near future, further theory advances will be needed. In my recent work, I combined geometrical insights with exact numerical techniques, to perform world-first computations of the analytic form of a plethora of five-point, two-loop scattering amplitudes in both phenomenologically relevant and formally interesting theories. In this project, I will apply this technology to a range of QCD processes, culminating in new results with immediate relevance for next-to-next-to-leading order corrections at the LHC and improved fundamental understandings of scattering amplitudes. First, I will systematically apply the approach to the computation of non-planar five-parton amplitudes in QCD. Second, I will calculate the non-planar master integrals relevant for all two-loop five-point processes with one massive leg, for example the production of a Higgs boson with two jets. Then, I will break current complexity thresholds by computing the phenomenologically relevant scattering amplitudes for the production of a W, Z, or Higgs boson, each with two associated jets. To achieve these lofty goals, I will draw on insights into the mathematical and physical structures underlying scattering amplitudes and employ modern tools such as finite-field arithmetic, analyticity-inspired techniques and computational algebraic geometry.
A Gaia and Herschel Study of the Density Distribution and Evolution of Young Massive Star Clusters (StarFormMapper)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Spain,France,Netherlands,United Kingdom,United Kingdom
Call: Scientific exploitation of astrophysics, comets, and planetary data (H2020-COMPET-2015, 2015)
Start date: 2016-06-01
End date: 2020-08-31
Duration (months): 51.0
Total project cost (EUR): 1779602.5
EU funding (EUR): 1775852.5
Participants: 7
Project status: CLOSED

We propose to use a combination of data from the ESA space missions GAIA and Herschel, alongside other satellite and European-led ground-based observations, to map the density distribution of star formation regions. This will allow us to identify the mechanisms that underlie both how massive stars themselves form, but more fundamentally, how their natal clusters evolve around them. Our work will underpin studies of how all galaxies evolve. The combination of the two ESA missions will allow us to study clusters and associations of stars when they are very young (much less than 1 Myr old), when the structures we see are a better match to the initial conditions. No one has attempted such a project before as the required datasets were not available. The novel data and complexity of the combined datasets require the development of new analysis and visualization tools. In particular we will statistically compare hybrid large scale N-body + SPH models with the combined 6-dimensional Gaia plus Herschel and gas kinematical data. Our goals therefore are structured to develop new techniques that we will initially test on simulations. We will follow this with tests on observational data of slightly older clusters (about 1Myr old). We will then apply the tested methodologies to the very youngest clusters. This will address our final goal of cracking the problem of how the most massive stars and clusters form.

Keywords: star formation,star clusters,massive stars