Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A NOvel FFR Measurement fOR accurate dEtermination of stenosis Functional severity in ischemic hEARt disease (NO_MORE_FEAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Netherlands
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Medis medical imaging systems BV (MEDIS), with 25 years of experience in medical imaging, will introduce a novel imaging-based biomarker as an accurate proxy for functional stenosis severity, creating a breakthrough in the treatment of ischemic heart disease (IHD). This non-invasive imaging algorithm should replace the current standard of using a vascular pressure wire to measure the Fractional Flow Reserve (FFR) - a measure for the physiologic significance of a coronary obstruction on the basis of which the interventional cardiologist decides whether an obstruction needs to be treated with stent placement, or otherwise should be left untreated. Using pressure-wire FFR is risky, time consuming, costly, associated with additional X-ray radiation, not always accurate and not applicable in highly curved arteries. MEDIS has developed a functional prototype of its imaging algorithm (FFRQCA) that accurately calculates the FFR from readily available 2D X-ray images through 3D reconstruction, advanced image processing algorithms and computational fluid dynamics. In a direct comparison with the current standard, this novel approach showed excellent diagnostic accuracy of 88%. Efforts to further optimise the technology are currently ongoing: a multi-centre investigator-driven trial is being carried out across 2 European countries, the US and China. In this Stage 1 SME Instrument project, MEDIS will investigate the commercial feasibility of this innovation that has already sparked enthusiasm amongst interventional cardiologists worldwide.

Keywords: ischemic heart disease,coronary heart disease,fractional flow reserve,3d angiography,algorithm
Unbiased niche identification and manipulation in stem cells and cancer (EnviroTag)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1809318.0
EU funding (EUR): 1809318.0
Participants: 1
Project status: SIGNED

For the longest time, researchers assumed that stemness is a cell-intrinsic feature. However, recently my work and the work of others have shown that specific microenvironments can restore stem cell identity in differentiated epithelial cells or induce transitions from one mature cell type to another. This instructive capacity of niches is equally important in homeostasis and disease. Like stem cells, cancer cells only survive in particular environments that nurture and protect them. This is particularly evident in the process of metastasis where only 1 out of 10 000 circulating tumor cells will find a suitable niche to grow. Nevertheless, our understanding of stem cell and cancer niches is still very limited. The main reason for this knowledge gap is the lack of suitable analysis tools. In the course of the EnviroTag project my team and I will generate a novel type of in vivo reporter system, which can label and genetically engineer the cellular environment of any cell of interest. We will use a multidisciplinary approach that combines the EnviroTag system with single cell sequencing, 3D-reconstructed confocal microscopy and organoid technology to study the dynamic roles of niche composition during tissue regeneration and cancer progression. Focusing on the gastro-intestinal tract, we will investigate how changes in the stem or cancer cell microenvironment control success and failure during tissue repair and the earliest steps of metastasis. Thereby, we will generate a new understanding of microenvironmental dynamics and uncover new regulatory mechanisms, signals and cell types that can be targeted to stimulate tissue regeneration or prevent metastatic spread. Objectives: 1) Establish a spatial in vivo reporter system for microenvironmental labelling and manipulation 2) Map functional interactions of stem cells and their niches during homeostasis and active regeneration 3) Identify the minimal niche requirements for metastatic engraftment and proliferation

Keywords: synthetic biology,organoids,single cell sequencing,cell signaling,mouse genetics,microenvironment,intestine,stomach,colon,regeneration,cancer
Decarbonisation of carbon-intensive industries (Iron and Steel Industries) through Power to gas and Oxy-fuel combustion (DISIPO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Japan
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-06-30
Duration (months): 27.0
Total project cost (EUR): 188442.24
EU funding (EUR): 188442.24
Participants: 2
Project status: CLOSED

The project presents a novel concept that combines Power to Gas (PtG energy storage) and oxy-fuel combustion (carbon capture) to decarbonise carbon-intensive industries (iron/steel as case study). PtG consumes renewable electricity to produce H2 (stored energy) and O2 (byproduct). This O2 is fed in the oxy-fuel furnace in the iron industry to attain a high concentrated CO2 stream, thus avoiding the energy penalization of requiring an air separation unit. Besides, the stored H2 and the captured CO2 are combined via methanation to produce synthetic natural gas to be used in the industry or distributed through the gas network. The overall objective of the project is to reach TRL 2 in the novel PtG–Oxy-fuel–Iron/Steel concept through the following research objectives: 1) To design, simulate and optimize the integrated layout of the novel concept, 2) To assess the maximum CO2 abatement under a proper operational strategy adapted to the industry and the availability of the renewable energy resource, and 3) To compare the concept with iron/steel industries operating with conventional CCS, under economic and life-cycle analyses. The training covers 1) simulation of energy intensive industries, 2) market and industrial criteria and constrains for adopting new technologies, 3) life-cycle assessment and 4) horizontal skills through a wide-ranging programme of activities. These objectives will be reached through a mobility period in Waseda University supervised by Prof. Nakagaki (over 20 years of experience in the topic and 71 patents in collaboration with industry) and a secondment to K1-MET (Austrian Competence Centre for Advanced Metallurgy, driven by the Austrian steel industry). The project is relevant for MSCA due the extensive planned training aimed to gain skills and maturity as researcher, and also because the proposed concept allows recycling CO2 in carbon-intensive industries whose emission-causing processes cannot be replaced with direct electrification.

Keywords: power to gas,industrial decarbonisation,oxy fuel combustion,renewable energy,energy storage
A Modular Earth System Model Emulator for Regional eXtremes (MESMER-X)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-03-01
End date: 2023-01-31
Duration (months): 23.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Climate extremes count among the most impactful consequences of climate change, also under low-emissions scenarios consistent with the aims of the Paris agreement. However, they are not factored in the derivation of emissions scenarios informing international policy options in reports from the Intergovernmental Panel on Climate Change (IPCC). Indeed, the Integrated Assessment Models (IAMs) underlying the development of these emissions scenarios only consider changes in mean climate when evaluating options for e.g. changes in agricultural production, biofuel production, afforestation or other land use changes. In the MESMER-X project, we will address this shortcoming by developing an operational Earth System Model (ESM) emulator providing climate extremes projections under different emissions and land use scenarios at negligible computational cost. This will allow for the first time a full interactive coupling between IAMs and climate scenarios. The MESMER-X emulator will be made open source and broadly available to scientists, policy-makers and society. The MESMER-X project will provide a disruptive innovation enabling the identification of realistic and resilient options for regional land use development consistent with a net-zero CO2 emissions future, with a focus on the European continent. The results of the MESMER-X project will be of high societal benefit for informing policy development consistent with the Paris agreement on European and global scale, including the European Green Deal

Keywords: climate extremes,climate change,earth system models,emulators,droughts,heatwaves,mitigation scenarios,impacts
Chip-based nanoscopy: an affordable, multi-modal and high-throughput super-resolution imaging platform (ChipNano)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Norway
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-08-01
End date: 2022-01-31
Duration (months): 18.0
Total project cost (EUR): 167142.86
EU funding (EUR): 110000.0
Participants: 2
Project status: CLOSED

The invention of optical nanoscopy is about to revolutionize several disciplines and it was awarded with a Nobel Prize in Chemistry in 2014. It is widely believed that a majority of existing optical microscopes will be replaced by an optical nanoscope. Unfortunately, the potential of the such a revolution and its widespread adoption are severely obstructed due to limitations of present day nanoscopy solution, i.e. system complexity, high cost and low throughput. In my ERC project, I have developed compact photonic chip-based optical nanoscopy, that can increase the throughput of convention optical nanoscopy by a factor of 100 times. The sample is placed on top of a photonic chip, capable of both holding and illuminating the sample, enabling to acquire super-resolved images. Photonic-chips can be retrofitted to an existing standard optical microscope converting it to high-resolution nanoscope. By way of analogy, moving from current super-resolution microscopy to chip-based nanoscopy will be as transformational as the move from main-frame computers to mobile phones. This is indeed a disruptive technology enabling widespread penetration of affordable chip-based optical nanoscopes. In ChipNano, the overall aim here is to bring the technology closer to the market by making the invention more commercially viable by a) co-operating and possibly setting-up business contract with the industrial partners on chip-production b) obtaining user feedback from key opinion leaders in Europe; c) consolidating business case to attract long-term venture funding in close cooperation with a university spin-off.

Keywords: optical microscopy,optical nanoscopy,integrated optics,lab on a chip,optical waveguide,bio imaging,super resolution microscopy
Breakthrough high performance cost competitive solar concentration system for combined heat and power generation (FOCALSTREAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain,Italy,Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2015, 2015)
Start date: 2016-05-01
End date: 2019-04-30
Duration (months): 36.0
Total project cost (EUR): 1457322.5
EU funding (EUR): 1018752.01
Participants: 3
Project status: CLOSED

The building sector is one of the key consumers of energy in Europe where energy use in buildings has seen a rising trend over the past 20 years. Buildings are responsible for around 40 % of energy consumption and greenhouse gas emissions in the EU. Moreover, electricity consumption in the residential and commercial building sector doubled between 1980 and 2000, and is expected to increase another 50% by 2025. The International Energy Agency (IEA) estimates that current trends in Energy efficiency in buildings will stimulate about half of energy supply investments to 2030, with a cumulative spending forecast in Europe of 622.8 billion € from 2014 through to 2023, (including products and services). On the other side, within the clean technologies the solar energy industry is one of the fastest growing forces in the market. Recent market research highlights the growth trend of the global PV installed capacity and revenue, from an annual 65,700 million € in 2013 up to a forecast of 105,850 million € by 2020 at an average CAGR 8.7%. Sungen, Jaca and Geetit have formed a consortium for the Focalstream project, in order to industrialise a novel product based on High Concentration Photovoltaic Thermal (HCPVT) technology and to train the critical stakeholders for its test, installation, operation and maintenance before the project finishes. Focalstream is a new cogenerator based in HCPVT technology with unique performances, gathering the most compact system in the market for thermal and electrical production in a single device. This novel HCPVT cogenerator produces simultaneously 3 kW electrical and 6 kW thermal power with an effective area 13.5 m2, saving a 55% of space , decreasing 40% the weight and increases 35% the solar light conversion compared with Solar thermal and Photovoltaic panels separately. Focalstream targets end users of buildings in the residential sector, where the electricity and heat demand can be easily covered with this system.

Keywords: solar energy,electricity,heat,high concentration photovoltaic thermal,cogeneration
Quantum Systems Investigated through Tensor Network States (quasiTENS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Tensor Network States (TNS) are a class of variational wave functions whose number of parameters can be increased systematically in order to improve the accuracy of the approximation. In effectively one dimensional systems, such as certain magnetic insulators, TNS reproduce the macroscopic properties of the ground state by 1 part in 10 million. TNS are expected to eventually give rise to similar accuracies in higher dimensions, though, in this case, their numerical implementation is much more sophisticated. The overall aim of this action is to establish TNS as a standard tool to tackle strongly correlated systems. In order to do so, we want to show that for several outstanding problems in Condensed Matter Physics they allow to approximate the relevant wave functions with unprecedented accuracy. First, we want to use TNS to tackle realistic chiral topological systems, which are characterised by a quantised transport property and might eventually be used to build quantum computers. Our second objective is to employ TNS to describe many-body localised systems, characterised by the absence of heat transport. In particular, we want to analyse different situations that are relevant to experiments, namely heat diffusion when the system is weakly coupled to a heat bath, the effect of symmetries, periodically driven (Floquet) systems, and many-body localisation in two dimensions. Another objective is to use a simple TNS ansatz to approximate the phase diagram of the Fermi-Hubbard model, which is believed to describe high-temperature superconductivity. We expect that the simplicity of the ansatz will shed more light on the physical properties of its phases. Finally, we also want to apply TNS in High Energy Physics, specifically to Lattice Gauge Theories, describing the most fundamental interactions between the particles that appear in nature. Our objective is to represent realistic gauge groups to make TNS suitable for variational calculations of Lattice Gauge Theories.

Keywords: tensor network states,quantum hall effect,chiral topological systems,many body localisation,fermi hubbard model,lattice gauge theory,quantum information and computation
Isotopic evidence for diet and mobility during the Neolithic transition to farming in the Near East (ISONEO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-10-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The Neolithic transition represents perhaps the most significant development in human history. In Europe the ‘Neolithic package’ arrived as a whole, and has been studied in detail using isotopic and genetic methods, but few isotopic studies have addressed the earlier and more complex transition in the Near East. Thus currently we know little about the changes in diet and mobility of individuals and cannot compare this crucial region to the later transition in Europe or to parallel transitions elsewhere. ISONEO will investigate the composition of diet in selected Neolithic populations of the Near East using carbon and nitrogen isotope analysis. Using strontium and oxygen isotopes in human tooth enamel ISONEO will explore the importance of migration in creating and sustaining the population of Pre-Pottery Neolithic B megasites and in the lifeways of the desert populations of the Pottery Neolithic and Chalcolithic in Jordan, Israel, and NW Saudi Arabia. The main sites used will be ’Ain Ghazal, Basta, Ba’ja, Kharaysin, Mallaha, Beisamoun, and Shubayqa. The results will be used to build a regional model of the diet, mobility and social changes that took place during the Neolithic transition in the Near East in a holistic synthesis with previous research based on traditional archaeological evidence including archaeobotany and archaeozoology. The Experienced Researcher, Dr Jonathan Santana will be supervised and trained by Dr Andrew Millard. Within the research intensive context of the Department of Archaeology at Durham he will enhance and expand his existing research skills, knowledge of practical techniques, and theoretical knowledge. He will be trained in stable isotope analysis and the interpretation of isotopic data, which will enable him to undertake the research for ISONEO. These new competencies will enhance his skills in scientific methods and critical thinking applied to archaeology and will increase his prospects for obtaining a permanent academic position.

Keywords: neolithic transition,pre pottery neolithic,pottery neolithic,chalcolithic,jordan,israel,saudi arabia,human mobility,human diet,carbon and nitrogen isotopes,strontium isotopes,oxygen isotopes
Video games for the prevention of depression and anxiety: A 21st century approach to emotional and mental health in adolescents (GEMH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-08-01
End date: 2021-11-30
Duration (months): 64.0
Total project cost (EUR): 1999509.85
EU funding (EUR): 1999509.85
Participants: 1
Project status: CLOSED

Depression and anxiety are the most frequently diagnosed mental health problems, leading to devastating long-term outcomes that affect a huge proportion of adolescents across the globe. Effective prevention programs are urgently needed; however, even our most advanced programs often lead to disappointing outcomes. Video games promise a groundbreaking, 21st century innovation: games provide learning environments that keep youth motivated and engaged to practice emotional resiliency skills that help prevent anxiety and depression. The education and medical fields have begun to harness the immense potential of games to teach new forms of thought and behaviour. Yet validated games for mental health are virtually nonexistent. The proposed program of research will: (a) Develop genre-breaking games which integrate biofeedback and evidence-based game mechanics that target anxiety and depression; (b) Test whether these games are more effective at reducing anxiety and depressive symptoms than the best conventional evidence-based prevention programs; and (c) Apply a novel, game-based methodology, to pinpoint the precise game mechanics responsible for training emotional resilience. With the multidisciplinary network of scientists and game designers that I lead – and a wide array of research designs, multi-method assessments and analytic techniques – this program of research promises to be the first of its kind. Results will establish the precise game mechanics that can successfully change causal factors that maintain anxiety and depression and provide a validated toolbox for efficient development of future applied games for a range of mental health concerns. These game-based engines for behavioural and emotional change will be mobilized through massive distribution channels (schools, social media), potentially making an unprecedented impact on the next generation’s prevalence rates of anxiety and depression.

Keywords: anxiety,depression,prevention,adolescents