Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Relapse in T-ALL: Resistant Clones and Therapeutical Options (RETRO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

T cell acute lymphoblastic leukaemia (T-ALL) is a rare disease that affects around 10-13 individuals in one million and affects pediatric and adult patients. High-dose chemotherapy is an adequate therapeutic treatment for most patients, however 10-20% of patients relapse and will require a bone marrow transplantation as a unique therapeutic window. T-ALL is a very aggressive disease and the rapidness in the response is crucial, however, one problem is that we cannot predict which patients will relapse. Several studies have been done to understand the origin of relapse, and there is evidence for several strategies for leukemia evolution: a) the relapse clone already exists at the time of diagnosis and is selected through treatment or b) treatment provides new mutations that will generate the relapse clone. Predicting the evolution of leukemic clones after chemotherapy pressure and understanding the specific mechanisms contributing to chemotherapy-resistant cell populations' appearance is necessary to improve cancer treatment. In our proposal, we wish to find feasible and clinically applicable ways to detect the earlier-stage clones that become resistant to chemotherapy. We wish to apply multiple approaches to better understand the specific clones like single-cell sequencing of primary T-ALL samples at diagnosis and relapse, and most importantly, compare their evolution with or without chemotherapy treatment through 2D, 3D culture and the current pdx in vivo model of leukaemia. Application of the 3D cell culture technique to T-ALL clonal evolution may represent a major scientific discovery to be used for different purposes focusing on disease modelling and relapse clone study. Our research will be pursued to optimize a method mimicking T-ALL in vitro, characterize the cells (and factors) causing the relapse, and use this information to identify new therapeutic options.

Keywords: cancer relapse,t cell leukemia,leukemic cells relapse,in vitro leukemic cell growth
STREAMLINED TEXTILE WASTE STREAMS FOR RECYCLING OPTIMIZATION (STREP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Denmark,Spain,Germany,Serbia,Czechia,United Kingdom,Ireland,Netherlands
Call: Circular solutions for textile value chains through innovative sorting, recycling, and design for recycling (HORIZON-CL6-2024-CIRCBIO-02, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 4999120.0
EU funding (EUR): 4999120.0
Participants: 14
Project status: SIGNED

STREP ambition is to empower the European textile (recycling) industry with a solution for sustainable processing of textile waste by developing and rolling out of a novel and systemic waste sorting solution based on cost-efficient sensor and automation technology, self-learning AI, as well as a novel solution for textile disintegration and mechanical recycling. Furthermore, STREP develops chemical recycling solutions, to facilitate the production of a 100% closed loop recycled yarn based exclusively on post-consumer textile waste, creating a perfect balance between sustainability, cost, and quality. The overall ambition is enhancing European industrial sustainability, competitiveness, and resource independence through producing more sustainable products, while increasing consumer benefits. STREP integrates value chain, product quality, and environmental impact perspectives in its different phases. Two of the innovations are placed in the pre-consumer phases. One of these relates to developing and testing guidelines and matrix that can support product design phase, and implementing recycling-friendly assembly of textile products. The other one innovates the traceability of the products and the related waste to enable allocating different product (waste) streams to the right flows and processing alternatives. The rest of the innovations are positioned after the textile waste collection and include: technology for recognition and removal of hardware and prints as well as characterizing the waste (fiber length, humidity, dirt, etc.), developing innovative recycling methods based on solvolysis, enzymatic processing, pyrolysis and hydrothermal conversion to treat the appropriate textile waste fractions depending on the composition and the length of the fibers. Targeted products are new fibers out of mechanical and chemical recycling processes as well as (bio-crude) oils and biochar out of the textile fibers that cannot be used in new fibers.

Keywords: artificial intelligence,iot,blockchain,chemical recycling,enzymatic recycling,lca,lcc
Multi-Material Additive Manufacturing of S690/Fe-Mn-Si-Cr-Ni SMA Joints with 30% Enhanced Static and Fatigue Life for Structural Applications through L-DED (MultiMAMSS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-28
End date: 2028-03-27
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 2
Project status: SIGNED

European Union (EU) is the world’s second-largest steel-producing region with an annual production of approx. 150 million tonnes. Since steel fabrication is one of the major sources of waste and CO2 generation in EU, novel approaches are therefore required to address this issue. Multi-material structural steel components fabricated through resource efficient laser directed energy deposition (L-DED) process that can bypass the characteristic strength ductility trade-off of steel structural components and therefore have a minimum 30% enhanced fatigue life are proposed in this project. The resource-efficient process of L-DED will provide a way for steel components fabrication with waste reduction and seamless material combinations that are otherwise difficult to attain. The developed multi-material components will also have a minimum of 30% enhanced lifecycle thus reducing waste generation from industries with considerable steel structural components applications. Initially, a digital framework with more than 90% accuracy will be developed through the finite volume method and discrete element method to evaluate and adjust the L-DED process and bypass expensive experimental approaches. Afterward, L-DED process parameters and interface strengthening approaches will be optimized for defect-free and high-density (>99% relative density) component fabrication. Lastly, the 30% enhanced life cycle of the proposed S690/Fe-Mn-Si-Cr-Ni multi-material structural joints under static, dynamic, and extreme thermal conditions will be established through experiments. The outcomes of the proposed project will help in providing the foundation for creating multi-material components with extraordinary and controllable behavior, as well as providing the L-DED process as a viable route for the fabrication of such components.

Keywords: ded,additive manufacturing,steel,metal 3d printing,modeling and simulation
Biomarkers of the interplay between brain networks and cardiac dynamics for the evaluation of non-invasive brain-computer interfaces (NETCORE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

Brain-computer interfaces (BCI) hold promise in the restoration of lost sensorimotor abilities after stroke, a leading cause of disability. Yet, their effectiveness varies because BCI typically need to be customized for each patient. For this, the development of objective markers for monitoring task performance, learning, and progress remains one of the main challenges in BCI. We aim to develop biomarkers to assess the effectiveness and progress of BCI interventions. NETCORE focuses on biomarkers derived from brain-heart interplay. This approach has proven valuable, as changes in brain-heart interplay correlate with disrupted perceptual abilities and even severity/mortality after brain damage. Notably, analyzing brain-heart interplay provides more insightful information compared to studying each organ separately. Our innovative methodology combines network science and biomedical signal processing to estimate interactions between these two systems in the context of motor imagery. We will explore various approaches, such as generative data methods, multi-layer networks, higher-order dependencies, and deducing potential causal interactions from physiologically informed neural models. Then, brain-heart interplay will be studied during BCI training progression in healthy participants, to later contrast with a subset of patients who suffered stroke. Traditionally, brain-damage research mainly focuses on the brain itself, overlooking its multisystem impact. Our ultimate goal is to pave the way for future biomedical breakthroughs in the emerging field of brain-heart interplay. Through these efforts, NETCORE strives to enhance the potential of BCI in aiding brain-injured patients and showing the potential of studying brain-heart interplay in healthcare and neuroscientific research. NETCORE's development will take place at the Paris Brain Institute, which provides an ideal interdisciplinary environment for this research in terms of expertise, equipment, and human resources.

Keywords: brain computer interface,stroke,rehabilitation engineering,network physiology,motor imagery
Dynamic cybersecurity management for organisations and local/regional networks based on awareness and collaboration (CS-AWARE-NEXT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Finland,Italy,Luxembourg,Greece,Netherlands,Austria
Call: Dynamic business continuity and recovery methodologies based on models and prediction for multi-level Cybersecurity (HORIZON-CL3-2021-CS-01, 2021)
Start date: 2022-07-01
End date: 2025-09-30
Duration (months): 39.0
Total project cost (EUR): 4995774.0
EU funding (EUR): 4993274.0
Participants: 23
Project status: SIGNED

CS-AWARE-NEXT aims to provide improved cybersecurity management capabilities to organizations and local/regional supply networks. Such organisations and networks operate in a highly dynamic cybersecurity environment, and are required to comply with prevailing European legislation such as the network and information security (NIS) directive. The way such organizations approach cybersecurity increasingly needs to be more dynamic and more collaborative, building on a shared situational awareness of potential cybersecurity issues relevant to the organisations and networks in question. To achieve this, CS-AWARE-NEXT has identified several focus areas to be addressed: (a) Improved organisational policy support to enable organizations to deal better with the dynamic nature of cybersecurity. (b) Greatly enhanced cooperation/collaboration within the organization and with external actors, such as those comprising the local/regional supply chain. (c) Better integration of threat intelligence in operational cybersecurity management using innovative AI approaches and techniques. (d) Much improved disaster recovery/business continuity, integrated in operational cybersecurity management. (e) Elevated evidence collection and information sharing with relevant actors on the multi-level European cybersecurity framework. (f) Improved capacity for enabling organizations to assess their security status in comparison with other relevant actors through benchmarking and profiling. CS-AWARE-NEXT builds on the awareness, cybersecurity information sharing, and system self-healing capabilities of the CS-AWARE platform developed during the H2020 project of the same name. The integration of the advanced capabilities of CS-AWARE-NEXT will enable organizations and dependent supply networks to be much more effective and efficient in their use of cybersecurity platforms like CS-AWARE, supporting their day-to-day cybersecurity risk and incident management operations.

Keywords: cybersecurity awareness cooperation collaboration socio technical analysis risk and incident management policy management information sharing threat intelligence
Ultra-coherent topological phononic waveguides—towards classical and quantum interconnect (UltraTopo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

Recent ten years witness great progress on reducing the loss of mechanical resonators by advanced dissipation engineering techniques, which stimulates creation and manipulation of quantum states of mechanical motion for various precise metrology and quantum physics. Furthermore, the mechanical system has shown the potential to enable crucial applications in connecting or mediating separate superconducting qubits and other quantum systems, and distributing information between them. These applications require another mechanical fundamental building block: phononic waveguides, which allow phononic states traveling along confined channels. To date, the loss of the phononic waveguides remains a major limitation preventing them from various applications, especially those in quantum regime. Employing the dissipation engineering techniques to remarkably reduce their propagation loss will greatly enhance their ability for interconnecting or mediating classical and quantum systems, but this have not been investigated yet. In UltraTopo, I will apply the dissipation engineering techniques to topological phononic waveguiding systems to reduce their loss. Topological phononic waveguides are extreme compatible with dissipation engineering due to their crystal structure, and they also provide topologically protected backscattering-immune phonon transport that is crucial for building large phononic networks. I aim to reduce the loss of waveguides to be at least 2 orders of magnitude lower than existing best systems. I will also take this advantage to demonstrate classical and quantum interconnection of two superconducting loop gap resonators separated by centimeters. The project will combine my expertise of topological phononic waveguiding, and expertise of dissipation engineering and quantum electro-/optomechanics from the host group. It will offer new schemes for hybrid quantum systems to many groups and also provide me a unique profile at a new frontier in the field of phononic.

Keywords: phononics,topological physics,mechanical dissipation engineering,quantum electro optomechanics,phononic waveguides
Scientific training Programme for Advanced Research and Knowledge in Light-Matter Engineering (SPARKLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark,Germany,Italy,France,Slovenia,Spain,Israel,Switzerland,Netherlands
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 3233937.6
EU funding (EUR): 3233937.6
Participants: 26
Project status: SIGNED

SPARKLE will build a mixed experimental and theoretical network to develop the necessary tools and techniques to exploit light-matter coupling to manipulate materials functionalities. SPARKLE will bridge the gap between photonics on the one hand and materials science on the other, by advancing the understanding of light-matter interaction via two distinct yet complementary approaches: (i) the utilization of tailored laser fields and (ii) the confinement of light in optical environments, called cavities. The network will connect leading academic and industrial experts, to push the development of novel detection techniques, innovative light sources, state-of-the-art ab-initio simulation methods and innovative designs of light-matter hybrid solid-state systems for devices at the interface of photonics, electronics and quantum technology. We are convinced that this topic is mature enough to provide Europe with a first generation of 14 early stage career scientists trained on interdisciplinary and intersectoral aspects of light and matter based technology, while at the same time pushing forward a cutting edge research field, the one of polaritonics. SPARKLE, will follow the guiding principle of "model - simulate - design - measure", providing the doctoral candidates with a unique multidisciplinary training which will place them at the forefront of the research on light-matter hybrid systems. They will collectively engage in a scientific endeavour, the control and manipulation of the quantum nature of material and light, that bridges the domains of theoretical solid state physics, quantum optics, ab initio material simulations, photonic engineering, laser physics and ultrafast spectroscopies. Last but not least the doctoral candidates will be equipped with the required entrepreneurship, innovation, organizational, “soft” and management skills to become successful future leaders in both academic and industrial environments.

Keywords: material science,solid state physics,quantum materials,experimental and theoretical spectroscopies,laser physics,light sources,quantum electrodynamics,nanophotonics
GAIA COFUND (GAIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Denmark,Norway,Spain,Croatia,Cyprus,Ireland,Germany,Georgia,United Kingdom,Poland
Call: MSCA COFUND 2023 (HORIZON-MSCA-2023-COFUND-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1432800.0
EU funding (EUR): 1432800.0
Participants: 24
Project status: SIGNED

GAIA COFUND will bring climate research-based knowledge – climate mitigation and adaption – into help solving real world problems and challenges. By connecting science with society in a practical manner, targeting research through a transdisciplinary approach involving industrial partners, we will pave the way for a climate academic career paths into industry. An eligible applicant will carry out a research project that will enable them to become future leaders, either in academia or in industry. The main objective of GAIA is to fund 15 two-year postdoc fellowships to excellent and promising young scientists from all over the World, with a strong emphasis on secondment in industry. GAIA will establish a postdoctoral training program that combine excellent and responsible research, open science, innovation, and climate change challenges, thus laying the foundation for the next generation of researchers rooted in climate science with a global outlook and an end-user perspective. With 24 partners, GAIA will offer access to an extensive academic and non-academic network Europe wide. The program will enable University of Southern Denmark (SDU) to elevate its strong position in climate research with world leading research groups, broaden the scope and sustainability of emerging research areas, and facilitate a vibrant and even more attractive research environment, combined with an outreach to local and international industrial partners looking for science-based solutions. SDU has 27,000 students and 3,800 employees with 24 departments within the faculties of the humanities, social sciences, natural sciences, health sciences, and engineering. SDU is ranked among the top universities in Denmark. GAIA will be part of the SDU Climate Cluster (SCC) established in 2022 with a budget of 15 M€, to create a versatile platform for groundbreaking, excellent, and interdisciplinary research within climate mitigation and adaption.

Keywords: climate,environment,sustainability,remediation,recycling