Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fluorination of Aryl Halide Compounds under Electrochemical-Flow Conditions (ElectroCatFlow)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-30
End date: 2022-09-29
Duration (months): 36.0
Total project cost (EUR): 271052.16
EU funding (EUR): 271052.16
Participants: 2
Project status: CLOSED

Fluorinated arenes are an invaluable class of organic compounds with important applications in pharmaceuticals, agrochemicals, and materials. Additionally, fluorine-18 has secured its place as the important radionuclide used in positron emission tomography (PET), largely due to attractive physical and nuclear characteristics. Through the years, use of transition-metal catalysis has revolutionised the access to these challenging compounds. However reliance on expensive catalysts and ligands, elevated temperatures, extended reaction times, and limited substrate scopes remain unsatisfied. This project untitled “Fluorination of Aryl Halide Compounds under Electrochemical-Flow Conditions” or “ElectroCatFlow” aims to develop a novel method to access aryl fluorides using a transition metal-catalysed fluorination reaction of aryl halides under electrochemical-flow conditions. ElectroCatFlow is highly interdisciplinary, involves mechanistic investigations, and applications of electrochemical-flow techniques to afford a mild, efficient and inexpensive method compared to current strategies. This project will generate broad interest from academia and industry, and will lead to high impact publications including scientific papers and potential patents. Finally, ElectroCatFLow will also maintain and improve European´s excellence in fluorination, catalysis and flow chemistry by creating a synergistic collaboration between the partner and institutions. Besides, this proposal aims to significantly influence on the EU healthcare system given the relevance of fluorine based drugs have in the Society.

Keywords: fluorination,flow chemistry,electrochemistry,catalysis,mechanism,medicinal chemistry
Brain to Brain Synchronization and the role of the shared semantics (B2B-sync)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-10-29
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

A successful verbal communication demands mutual attentiveness and intelligibility of speech. Nevertheless, to transmit certain meaning, alignment between interlocutors according to their concepts and representations is also necessary. Recently, it has been shown (by the applicant and others) that a successful linguistic interaction is related to interbrain coupling. However, the role played by the inter-brain synchronization of oscillatory activity, for the two persons to understand each other is still not known. We propose a research agenda that aims at discovering the interplay between semantics and brain-to-brain synchronization. We will use coupled participants to analyze the inter-brain synchronization patterns underlying successful and disrupted verbal communication. Specifically, we will study two persons engaged in a seemingly natural linguistic, communicative scenario while simultaneously recording EEG brain activity. Using two different types of transcranial electric stimulation, we will study the contributions of a shared meaning to the inter-brain synchronization. In the proposed research, we will use TMS to disrupt semantic-specific brain regions to determine how experimentally-impaired communication modulates interbrain synchronization. Also, we will use tACS to manipulate neural coupling between participants trying to modulate mutual comprehension. Our study will thus provide important and novel evidence for the underlying interbrain patterns during effective communication and concerning whether interbrain phase coupling and mutual understanding are jointly modulated (linked). Results here would be opening the door to the quantification of linguistic interactions. In turn, they might suggest new methods for enhancing verbal communication in populations with meaning transmission deficits. Also has the potential to enable the implementation of methods and devices with the intended purpose of measurement and intervention over the interbrain coupling.

Keywords: brain to brain synchronization,interbrain coupling,semantic cognition,neurostimulation,hyperscanning
The “parasitism-readers” of the world’s most damaging plant-parasitic nematode Meloidogyne incognita: new avenues to address food global security. (Mi-DOG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2023-03-31
Duration (months): 36.0
Total project cost (EUR): 286470.4
EU funding (EUR): 286470.4
Participants: 2
Project status: CLOSED

My proposal aims to understand how root-knot nematodes cause disease in the host plant. Understanding how these parasitic worms cause disease is important because they have a worldwide distribution, they infect thousands of different plant species, and ultimately they represent a major constraint on achieving food security in Europe and beyond. In this proposal I will link my expertise in root-knot nematodes at molecular and proteomic levels, with the host group expertise in the regulation of parasitism genes, to understand how the most economically damaging root-knot nematode Meloidogyne incognita successfully controls the process of plant-parasitism. My proposal builds on the recent discovery of a non-coding DNA motif that is specifically enriched in the promoter regions of approximately 100 genes expressed in the root-knot Meloidogyne incognita dorsal gland (named Mi-DOG box). This discovery leads to two important ideas: Firstly, given that many effector proteins produced in this gland are delivered into the plant during infection, the Mi-DOG promoter is probably involved in the regulation of parasitism. Secondly, being a non-coding DNA motif, the Mi-DOG box is probably recognized by an associated protein or protein complex, a “reader” that coordinates the expression of secreted parasitism proteins, and ultimately orchestrates the process of plant parasitism. In a formal connection between two world-class research institutions, the main objectives of my proposal are therefore to: 1) Identify the “readers” of Mi-DOG box using a combination of well-established and highly-innovative CRISPR-mediated methodologies, and 2) characterize the spatio-temporal expression pattern and functional role of these “readers” in M. incognita parasitism. Overall, my proposal describes a novel scientific approach to address an emerging area of great promise with considerable translational potential, and ultimately to open up my best career opportunities for the future.

Keywords: agriculture,global food security,disease control,plant parasitic nematodes,parasitism effectors
Exploring the New Science and engineering unveiled by Ultraintense ultrashort Radiation interaction with mattEr (ENSURE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1887500.0
EU funding (EUR): 1887500.0
Participants: 1
Project status: CLOSED

With the ENSURE project I aim at attaining ground-breaking results in the field of superintense laser-driven ion acceleration, proposing a multidisciplinary research program in which theoretical, numerical and experimental research will be coherently developed in a team integrating in an unprecedented way advanced expertise from materials engineering and nanotechnology, laser-plasma physics, computational science. The aim will be to bring this topic from the realm of fundamental basic science into a subject having realistic engineering applications. The discovery in 2000 of brilliant, multi-MeV, collimated ion sources from targets irradiated by intense laser pulses stimulated great interest worldwide, due to the ultra-compact spatial scale of the accelerator and ion beam properties. The laser-target system provides unique appealing features to fundamental physics which can be studied in a small lab. At the same time, laser-ion beams could have future potential in many technological areas. This is boosting the development of new labs and facilities all over Europe, but to support these efforts, crucial challenges need to be faced to make these applications a reality. The goals of ENSURE are: i) design and production of nanoengineered targets, with properties tailored to achieve optimized ion acceleration regimes. This will be pursued exploiting advanced techniques of material science & nanotechnology ii) design of laser-ion beams for novel, key applications in nuclear and materials engineering iii) realization of engineering-oriented ion acceleration experiments, in advanced facilities iv) synergic development of all the required theoretical support for i,ii,iii). The results of the project can determine a unique impact in the research on laser-driven ion acceleration in Europe, providing new directions to support the attainment, in the next future, of concrete applications of great societal relevance, in medical, energy and materials areas.

Keywords: laser plasma interaction,nanotechnology,nuclear engineering,thin films,nuclear science,ion beam diagnostics,materials irradiation,particle accelerators,relativity,non linear physics
The threats and solutions to urban tree pests and pathogens in a changing climate (TREEPACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2024-10-07
Duration (months): 36.0
Total project cost (EUR): 244209.6
EU funding (EUR): 244209.6
Participants: 1
Project status: SIGNED

TREEPACT investigates the social, environmental, and economic impacts of urban tree pests and pathogens in the context of a changing climate. Disturbances due to tree pests/pathogens are expected to increase in cities, potentially threatening endeavours to increase canopy cover to help adapt to climate change. This novel research programme uses an innovative combination of qualitative and quantitative methods, including a systematic review, surveys, stakeholder and policy analyses to assess impacts, risk perceptions, policies, and responses of city professionals involved in urban greenspace and forest planning and management. Although the study’s reach is global, it will use Munich as a case study example. The city has recently been subject to devastating tree pest/pathogen outbreaks, destroying up to 60% of the trees in entire neighbourhoods. The action will have impact in two areas. From a policy perspective, it will produce new understanding of the various policy and management responses to urban tree pests/pathogens around the globe. It will also synthesise existing knowledge on the impacts of tree pests/pathogens. From an academic perspective, it will 1) produce new knowledge about the risk perceptions and responses to tree pests/pathogens of greenspace professionals and advocates in cities, 2) develop a social network analysis method in the context of urban planning, and 3) consolidate and assess existing knowledge in a new context.

Keywords: urban forest,urban trees,tree pests,tree pathogens,green infrastructure,stakeholder perceptions,impact assessment,policy analysis,stakeholder analysis,climate change,natural disturbances
SDGine for Healthy People and Cities (SDGine)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2019, 2019)
Start date: 2020-10-01
End date: 2026-06-30
Duration (months): 69.0
Total project cost (EUR): 1952640.0
EU funding (EUR): 976320.0
Participants: 1
Project status: SIGNED

The goal of “SDGine for Healthy People and Cities” will be to deliver a world-class training programme at Universidad Politécnica de Madrid (UPM) for 12 ESRs mainly in the STEAM disciplines (Science, Technology, Engineering, Architecture, and Applied Mathematics), with a strong focus on Sustainable Development Goals (SDGs). SDGine's fundamental objectives will be to develop technologies and tools that accelerate the compliance with SDGs related to climate change and social transformations needed in urban contexts. ESRs will complete Industrial and International Doctorates (through UPM’s Doctoral Division & International Doctorate School and the existing 45 Doctoral Programmes) connected with the notion of innovation platform, a systemic approach aligned with major international programs in which UPM participates (EIT Digital, EIT Health, EIT Raw Materials and Climate Knowledge Innovation Community) and Horizon Europe Missions. SDGine will enhance mobility between countries, sectors and disciplines. All trained ESRs will become highly (self)-employable for future research positions in academia and non-academia. SDGine will follow the Seven EU principles on Doctoral Training and will contemplate the Triple-“i” dimension through: i) International secondments; ii) Intersectoral collaboration agreements with industry; and iii) Interdisciplinary PhD supervision. Moreover, the innovation & entrepreneurship dimension of the PhD thesis projects will be enhanced. SDGine will be aligned with the "Charter & Code" for researchers, since UPM has received the HR Excellence in Research award, and will include excellent training in research, complementary and transferable skills (cross-cutting disciplinary seminars, summer schools, writing days...). The programme will have high societal impact through SDGs as well as a positive impact not only in ESRs’ career development and future job opportunities, but also in the UPM, the region of Madrid, Spain, the EU and beyond the EU.

Keywords: international doctorate,industrial doctorate,sustainable development goals,steam
Developing Multipurpose Nicotiana Crops for Molecular Farming using New Plant Breeding Techniques (Newcotiana)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Australia,Spain,Germany,Germany,Italy,Spain,Spain,Spain,Switzerland,Belgium,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: New Plant Breeding Techniques (NPBT) in molecular farming: Multipurpose crops for industrial bioproducts (H2020-NMBP-BIO-2017, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 7363310.0
EU funding (EUR): 7199560.0
Participants: 21
Project status: SIGNED

A group of New Plant Breeding Techniques (NPBT) has opened unprecedented opportunities in agriculture. Those NPBTs are at least as efficient and often more precise than previous traditional and GM techniques, while circumventing the introduction of heritable transgenes from distant species in the plant genome. Properly communicated, NPBTs are expected to gain wide acceptance, especially when applied to breeding objectives which are seen as beneficial for the society. A well-perceived objective is Molecular Farming, which refers to the use of plants for the production of valuable biomolecules (e. g. biopharmaceuticals). Cultivated tobacco (Nicotiana tabacum) and its close Australian relative Nicotiana benthamiana, are preferred species in Molecular Farming due to their favourable features: non-food crops, easy tissue regeneration, high productivity, rich secondary metabolism and availability of genetic tools. In sharp contrast, traditional tobacco cultivation is in serious decline in the EU, causing serious social problems in many rural areas. NEWCOTIANA aims to revitalize those areas by breeding efficient Nicotiana biofactories of high-value non-smoking products as alternatives for traditional tobacco crops. NEWCOTIANA will develop the most advanced tobacco NPBTs toolbox, easily transferable to other plants. This will position EU in the avant-garde of breeding innovation. This toolbox will be used to create elite multipurpose Nicotiana varieties improved in product-specific traits (bioproduct quality, stability and yield), next to more general traits as biomass, resilience and biosafety. The “Newcotiana” varieties will be carefully tested in relevant pre-industrial environments for the production of end-value chemicals, namely proteins and metabolites for health and nutriceutical use. Ethical, social and legal aspects will be closely monitored and public and stakeholder engagement will be assured using innovative science communication methodologies.

Keywords: new plant breeding techniques,nicotiana,tobacco,benthamiana,crispr,cas9,genome editing,agroinfiltration,cisgenesis,intragenesis,grafting
Healthcare- and pharma-economic models in support of the International Consortium for Personalised Medicine (HEcoPerMed)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Germany,Austria,Hungary,Netherlands,United Kingdom
Call: Actions in support of the International Consortium for Personalised Medicine (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 1998437.5
EU funding (EUR): 1998437.5
Participants: 6
Project status: CLOSED

HEcoPerMed responds to the demand for economic models that evaluate treatments made possible through innovations in personalised medicine and seeks to identify funding and reimbursement mechanisms that provide financial incentives for the rapid development and uptake of such innovations. HEcoPerMed goes beyond current assessment and payment models in order to serve the requirements of personalised medicine for more compre-hensive cost-effectiveness estimates that incorporate patient and societal perspectives and enhance sustainable affordability of cutting-edge health innovations. HEcoPerMed will provide an overview of and guidance on high-quality methodological approaches for model-based economic evaluations. In three case studies, HEcoPerMedwill apply state-of-the art economic modelling to demonstrate practical and methodological issues in evaluating personalised medicine innovations. The project team will also study existing shortcomings in stimulating the adoption of personalised medicine and pro-pose financial agreements that accelerate its diffusion in European health systems. HEcoPerMed will construct future scenarios, considering the trends and drivers as well as challenges and benefits of personalised medicine for the European social model of care and its financial viability. For a better financial integration of personalised medicine and new economic models, the project team will develop appropriate diffusion and communication strategies to be in direct contact with experts and a wide variety of stakeholders, taking their needs into account while offering new solutions for the players within the European health systems. These comprehensive measures will fill a gap identified by the ICPerMed to support their efforts in the promotion of personalised medicine in Europe and beyond. The project will support health care decision makers to manage their budgets while providing the best possible care for patients in the field of personalised medicine.

Keywords: health economics,health policy,social system,future studies,modelling,simulation,evaluation of health care payment models
Cancer prevention and early detection among the homeless population in Europe: Co-adapting and implementing the Health Navigator Model (CANCERLESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Austria,Belgium,Greece,Greece,Netherlands,United Kingdom
Call: Global Alliance for Chronic Diseases (GACD) - Prevention and/or early diagnosis of cancer (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 2820326.25
EU funding (EUR): 2820326.25
Participants: 12
Project status: SIGNED

Cancer is one the leading causes of death in Europe in the general population with reports noting the cancer-related mortality twice as high in the homeless population. Reasons for this excess are linked to risky health behaviours as well as significant barriers experienced by homeless people when trying to access the often highly fragmented health care systems. Timely and evidence-based preventive strategies including optimizing health care pathways provide a solution to the high cancer mortality and could improve overall health outcomes in this underserved population. The aim of the CANCERLESS project is to deliver an innovative solution as an aggregate intervention based on the combination of the tested Patient Navigator Model and Patient Empowerment Model to create the Health Navigator Model for Europe. The Health Navigator Model is an evidence-based patient-centred intervention which develops patient empowerment through health education and social support and promotes timely access to primary and secondary prevention services. CANCERLESS includes partner organizations with long-standing experience in working in the field of health and social care for the homeless in the south, east, northwest and central Europe, as well as academic institutions and local governments. Using the Consolidated Framework for Implementation as well as the Research and the Reach, Effectiveness, Adoption, Implementation and Maintenance frameworks based on implementation science know-how, the CANCERLESS project aims to reduce the gap in health inequalities for the homeless population by reducing cancer burden, which will, in turn, reduce associated costs across health and social care systems in Europe. Moreover, the CANCERLESS project aims to harness the transformative potential of the integrated care pathways in cancer as well as provide health and social care policy recommendations for the adoption and implementation of the Health Navigator Model across Europe.

Keywords: person centred care,cancer prevention,homelessness