Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
State-of-the-art sustainable energy efficiency technologies roadmap for waterborne transport towards the fit-for-55 guidance compliance (FLEETfor55)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Greece,Italy,Norway,Spain,Germany,Malta,Portugal,United Kingdom,Liberia,Cyprus
Call: Combining state-of-the-art emission reduction and efficiency improvement technologies in ship design and retrofitting for contributing to the "Fit for 55" package objective by 2030 (ZEWT Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 9892622.5
EU funding (EUR): 7426096.0
Participants: 23
Project status: SIGNED

FLEETfor55 is an ambitious project to align the European waterborne sector with the EU's "Fit for 55" environmental targets for 2030. This will be done through a holistic roadmap that identifies the most cost effective and sustainable implementation of Energy Efficiency Technologies (EETs) onboard short sea, inland waterway and high seas vessels. To achieve this, FLEETfor55 will evaluate EETs paired with new vessel designs and retrofits – collectively defined as use cases. Six retrofit use cases and four new vessel design use cases, each employing a "design-for-operation" approach will be optimised for both energy use and environmental compliance throughout each use case’s lifetime and for different operational scenarios. Additionally, the project will integrate a decision support system into a web-based digital platform to rapidly assess and benchmark use cases, achieving quantifiable energy efficiency savings and reduced emissions. This system assesses use cases with the help of key performance indicators that align with the EU’s 'Fit for 55' legislative package and the International Maritime Organization’s indices such as CII/DCS, EEXI, and EEDI. Key strategies include developing detailed business models for each use case to ensure market adoption, and the establishment of the Technologies Innovation Network. The latter will ensure that EETs are effectively matched with end users, promoting the adoption and practical implementation of new technologies in the waterborne transportation sector. These initiatives position FLEETfor55 not only meet stringent EU environmental standards but also to set a new benchmark for future environmental excellence in waterborne transportation.

Keywords: retrofit,new building,new designs,vessels,waterborne transportation,inland waterways,seagoing,sustainability,carbon neutral,emissions reduction,energy efficiency,technologies
Co-creating coexistence: Advancing policies, practices, and stakeholder engagement for integrating wildlife and livestock into sustainable multi-functional landscapes in Europe (CoCo)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Norway,Germany,Italy,Slovenia,Greece,Romania,Spain,Sweden,Poland,Belgium,France,Latvia
Call: Agro-pastoral/outdoor livestock systems and wildlife management (HORIZON-CL6-2024-FARM2FORK-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 4935552.32
EU funding (EUR): 4876764.11
Participants: 20
Project status: SIGNED

The recovery of wildlife populations (large carnivores and large herbivores) has created many additional challenges for pastoralism, already under pressure from multiple socio-economic drivers. These challenges include damage (depredation), extra costs, and many social conflicts. Some of the major obstacles to addressing these challenges are conflicts between stakeholders and the contested nature of relevant knowledge. The CoCo project will address these obstacles by adopting a multi-disciplinary approaches with a strong social science representation and a Multi-Actor Approach with widespread stakeholder engagement that facilitates co-creation of knowledge with high legitimacy. The process will cover (a) the relationship between livestock husbandry practices and damage from wildlife, (b) ways to integrate wildlife management and pastoral management, (c) perceptions and values that different stakeholders have about the pastoralism-wildlife interface, (d) experience with different governance structures, (e) the potential of new and emerging technologies in both wildlife and pastoral management and monitoring, and (f) a cost benefit analysis of different scenarios for pastoral and wildlife management. The project will use methods as diverse as systematic reviews, field inspections, face-to-face interviews, focus groups, questionnaires and modelling. The project’s ambition is to collect original quantitative data from at least 1000 pastoralists, 1000 hunters and 1000 landowners and qualitative data from 100’s of stakeholders deployed in a comparative way across 12 countries. The insights stemming from the reviews, the analysis of new data, and the modelling will be integrated into a Roadmap for Coexistence that produces policy relevant recommendations for a better standardization, harmonization and integration of both pastoral and wildlife management systems. This will reduce conflicts and secure multi-functional landscapes for both pastoralists and wildlife.

Keywords: pastoralism,human wildlife conflict,livestock production,multi functional landscapes,high nature value farming
PAST TO FUTURE: TOWARDS FULLY PALEO-INFORMED FUTURE CLIMATE PROJECTIONS (P2F)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Netherlands,Denmark,Germany,United Kingdom,Spain,Belgium,Switzerland,United States,Australia
Call: Paleoclimate science for a better understanding of the short- to long-term evolution of the Earth system (HORIZON-CL5-2024-D1-01, 2024)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 14997764.0
EU funding (EUR): 14997764.0
Participants: 24
Project status: SIGNED

The project Past-to-Future (P2F) aims at radically advancing our knowledge of past climatic conditions to better understand Earth’s climate response to different kinds of forcing, with considerable focus on potential abrupt climatic transitions and the crossing of tipping points. To this end, P2F will integrate information from paleoenvironmental proxy data, from Earth system models (ESMs), and from rigorous theoretical approaches. Being able to reconstruct past climate evolution is a necessary step for enhancing our capacity to look into the future and, therefore, extensive improvements of state-of-the-art ESMs are needed. So far, ESMs are mainly calibrated and validated with respect to the instrumental records of the last ~170 years of relatively stable climate, while the Earth’s longer-term history is characterised by an interplay of gradual climate change, variability and critical transitions between competing states, with profound impacts on climate subsystems, ecosystems, and civilisations. Understanding the leading dynamical processes and feedbacks and in particular improving our ability to model and anticipate critical transitions in the climate and ecosystems is key to project future climate change on spatio-temporal scales relevant for societies, ecosystems and the planet. In this context, P2F will critically advance our ability to understand and anticipate the main climatic and societal impacts of the ongoing climate crisis. Specifically, P2F will extend the reach of Earth System Models and demonstrate a step change in the model development cycle of the Climate Model Intercomparison Project (CMIP), by providing fully paleo-informed models for future projection and producing a portfolio of plausible future climate change scenarios that are constrained by documented past climate changes and abrupt transitions. Finally, P2F will efficiently disseminate research outputs and engage key stakeholders in dialogue to ensure appropriate synergies are at attained.
Fluorescent boron-cluster dyes as biocompatible photosensitizers with promising antimicrobial and anticarcinogenic activity (JAVIEROH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-16
End date: 2026-01-15
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

The increasing resistance of microorganisms (bacteria, virus, fungi...) against antimicrobials and antiseptics is one of the most challenging topics in current medicine and biology. Statistics from the Centre for Disease Control and Prevention suggest that bacterial resistance to antibiotics causes over 20.000 deaths every year in EU member states alone. The European Centre for Disease Prevention and Control (ECDC) alerts that healthcare-associated infections caused mainly by multidrug-resistant (MDR) bacteria remain a public health issue and emphasizes the importance and urgency to search for effective alternative approaches based on completely different mechanisms. One of the promising approaches to fight against infections is the antimicrobial photodynamic therapy (aPDT) using biocompatible photosensitizers. Compared to classical antimicrobials, the biggest advantage of aPDT is the very low probability that the target microorganisms have the opportunity to develop resistance. Furthermore, aPDT can be synergistically combined with other antibacterial treatments, such as radiotherapy, antibiotic treatments, and photothemal therapy, to improve its antibacterial efficiency. The main goal of this project is to engineer novel boron rich biocompatible photosensitizers, with suppressed π-π interactions and herewith enhanced for efficient singlete O2 production, to be used in a twofold objective: a) as aPDT agents for the inactivation of microorganisms in sanitary instruments and medical devices; b) as antitumor agents in dual PDT-BNCT cancer therapies. The innovation is focused on the development boron content PSs with multiple applications both for antimicrobial (aPDT) and anti-cancer (PDT and BNCT)

Keywords: biocompatible photosensitizers,antimicrobial phodinamic therapy,boron neutron cancer therapy
Enteric Bioelectronics for Sensing and Stimulating the CNS (EnterBio)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,Greece,France,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2634485.25
EU funding (EUR): 2634485.0
Participants: 7
Project status: SIGNED

Therapies for neurological disorders often involve deeply invasive brain operations or implants. A largely overlooked aspect of these conditions is the high comorbidity of GI-related disorders. Although the top-down relationship between the brain and peripheral organs has dominated the field, it’s now clear that activity of peripheral organs, in particular GI innervation – the enteric nervous system (ENS) – not only influences brain activity, but also paces and regulates it. Indeed, recent studies have shown the bidirectional relationship between gut homeostasis and neurological function in disorders such as epilepsy, Alzheimer’s, and Parkinson’s. EnterBio will adapt bioelectronic tools developed over the past decades for application in the CNS for sensing and stimulating the ENS, and thereby sensing and stimulating the CNS. The team comprises world-leading expertise in organic and graphene bioelectronics, drug delivery, in vitro/animal models of neurodegenerative disorders, and molecular/ cellular physiology of the PNS. We propose to turn this expertise toward the ENS to develop a platform for elucidation, prediction, and control of CNS function. Objectives are to: – Develop bioelectronic sensors, stim. electrodes, and drug deliv. targeting ENS and adapted for implantation in the gut – Elucidate ENS control of CNS using high-res sensing signals in vivo – Demonstrate control & eventual therapy for CNS disorders without highly invasive implants EnterBio proposes to build on new, cutting-edge directions (organic/carbon-based bioelectronics and the gut-brain axis) to disrupt the field of CNS sensing/neuromodulation as technology to utilize ENS activity as an entry point to brain (dys)function is lacking. “Entering the bio” through the gut will be exactly this disruptor. EnterBio will achieve substantial improvements in relation to the barriers and obstacles of today’s sensing/neuromodulation technologies.

Keywords: organic electronics,bioelectronics,iontronics,gut brain axis,enteric nervous system
Reestablishing the lung microbiome : preclinical evaluation of targeted probiotics for pneumonia treatment (RESTORE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-08-01
End date: 2028-07-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: SIGNED

Nosocomial pneumonia is the second most common and most frequently fatal hospital-acquired infection worldwide. Previous understanding of lung health depicted a dichotomous view of microbial status (sterile vs. infected), leading to "one-size-fits-all" treatments that primarily target pathogens but neglect the complex host-microbiome interaction. The RESTORE hypothesis is that re-establishing the healthy respiratory microbiome core using a probiotic composed of lung-specific commensal bacteria and/or their derived metabolites can mitigate pneumonia severity by modulating pathogens and mucosal immunity. My main objectives are: 1) define lung-specific bacterial consortium and their derived metabolites/peptides, whose elimination is associated with pneumonia severity; 2) test their effects in vitro on commensal bacteria and pathogens; and 3) evaluate their impact on pathogens multiplication, microbiome composition, and lung mucosal immunity. I will use data from existing cohorts to identify bacterial consortia with pneumonia severity and integrate multi-omics data to characterize these consortia and their metabolic products. Then, I will assess the interactions within the bacterial consortium and their effects on pathogens by analyzing the growth and transcriptional responses. Finally, I will investigate their therapeutic potential in pneumonia mice models, focusing on pathogen burden, microbiome composition, transcriptomic activity, and immune modulation using single-cell RNA sequencing and flow cytometry. RESTORE represents a pioneering approach by leveraging the lung microbiome to develop non-antibiotic, lung-specific strategies, addressing the complexity of pneumonia pathophysiology beyond pathogen eradication. By employing a multi-disciplinary integration of cutting-edge methodologies, this project could revolutionize pneumonia treatment and potentially extend to other infectious diseases.

Keywords: microbiome,nosocomial pneumonia,bacterial pathogens,probiotics,metabolites peptides,mucosal immunity,mice pneumonia models,immune modulation,multi omics data,host microbiome interaction
Rashba Effect-induced non-VOLatile ferroelectric control of spin-orbit coupling in Two-dimensional materials (REVOLT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: TERMINATED

The surge of electronic devices in our everyday lives poses severe challenges to the sustainability of our societies. Spintronics stands at the forefront of solutions considered today by leading industrial actors to drastically improve information and communications systems' scalability and power efficiency. In this field, most of the efforts focus on information storage based on ferromagnets (FM), readout via spin-charge interconversion (SCI) phenomena, i.e. the conversion of a spin polarisation into a detectable electrical signal, or vice-versa. However, improvements in SCI efficiency are still necessary and solutions for the electrical writing of FM still need to be more efficient and reliable. Ferroelectrics (FE), which naturally break inversion symmetry, may allow an efficient SCI when interfaced with other materials. Since FE also carry information (their electric polarisation) switchable at ultra-low power, they are ideal candidates to replace FM as the new core elements of spintronics. So far, only a few reports demonstrated the FE control of SCI at oxide interfaces or in bulk semiconductors. Due to their richness and 2D nature, van der Waals (vdW) materials and notably graphene play an increasingly important role in spintronics research, and vdW FE could be a game changer for the field, although they are still under-investigated. REVOLT aims to study these novel FE and to achieve the non-volatile electric control of SCI in graphene proximitized with FE. Structural, electrical, and magnetotransport characterisations will be performed on atomically sharp FE/graphene stacks patterned with advanced nano-lithography techniques for which the host institution is expert. Based on these efforts, REVOLT will shed new light on fundamental physics phenomena and evaluate the potential for a paradigm change in spintronics applications while providing high-quality, interdisciplinary research and transversal skills to a young researcher for the development of his career.

Keywords: ferroelectricity,graphene,2d materials
The brain erythropoietin cycle as driver of adaptive neuroplasticity via functional hypoxia (BREPOCI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2028-03-31
Duration (months): 67.0
Total project cost (EUR): 2495594.0
EU funding (EUR): 2495594.0
Participants: 3
Project status: SIGNED

Cognitive disability and decline play key roles in neuropsychiatric conditions but lack effective therapies. Erythropoietin (EPO) is a hypoxia-inducible growth factor, named after its original description in erythropoiesis. We discovered - by 'reverse approach' (human trials first) - that recombinant human (rh) EPO has potent procognitive effects, hematopoiesis-independent. Searching for mechanistic insight in mice, we saw that rhEPO markedly drives differentiation/maturation of pyramidal neurons and oligodendrocytes from non-dividing precursors in cornu ammonis, outside known neurogenesis areas. In parallel, rhEPO dampens microglia. This suggests that endogenous, brain-expressed EPO (bEPO), acting in auto/paracrine fashion, has fundamental, hitherto overlooked physiological significance. BREPOCI will pursue the groundbreaking hypotheses that (I) 'functional hypoxia' is a physiological consequence of increased neuronal activity, inciting an integrated response of many brain cell types and (II) this activity-induced hypoxia stimulates bEPO expression to optimize multicellular brain plasticity, providing substantial 'hardware upgrade'. (III) Also, BREPOCI postulates diverse EPOR in brain and will study their nature and contribution to these pivotal processes upon normoxia, 'functional', and inspiratory hypoxia. (IV) rhEPO treatment of intellectual disability/autism caused by Tbr1 or Zbtb20 loss-of-function mutations will constitute a first mechanistic approach to specific brain pathologies, translatable to humans. This ERC project can build on acquired novel genetic mouse tools (cell-type specific EPO/EPOR mutants, inducible hypoxia reporters, multiomic mice), sophisticated behavior tests, MRI/MRS, multiphoton imaging, NanoSIMS, sc/snRNA-seq, confocal/Lightsheet/electron microscopy, electrophysiology. BREPOCI will illuminate rhEPO/bEPO effects on physiological brain functions and explore how it limits developmental delay, intellectual disability, or neurodegeneration.

Keywords: hypoxia,motor cognitive challenge,erythropoietin,epo,erythropoietin receptor,multicellular brain plasticity,autism,cognitive disability,cognitive decline