Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainability Transition Assessment Rules for Bio-Based Systems (STAR4BBS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Coordination and support actions
Countries involved: Germany,Italy,United Kingdom,Greece,Spain,Netherlands,Switzerland
Call: International and EU sustainability certification schemes for bio-based systems (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1776419.5
EU funding (EUR): 1776419.25
Participants: 11
Project status: SIGNED

STAR4BBS is a three-year multidisciplinary and multi-actor collaborative project, involving seven partners, three associated partners and one linked third party. The overall aim of STAR4BBS is to maximize the potential of Sustainability Certification Schemes (SCS) and labels to support a successful transition to sustainable bio-based economy. At the core of the STAR4BBS project is the development of indicators and a new monitoring system for assessing the effectiveness and robustness of existing international and EU SCS, B2B labels, and related traceability systems applicable to biological feedstock and bio-based materials and products. This information will create the foundations to support achieving the much needed harmonization between schemes and transparency in global and EU trade flows. Through the developed new monitoring system, existing SCS and labels will be analyzed, and the results, as well as additional research on certified and uncertified trade flows and on the impacts and costs and benefits of certification and labels, will substantially increase understanding of the potential of these schemes to contribute to policy and industry sustainability goals and will build awareness of the differences between the schemes. The project will involve important stakeholders (including scheme owners, policy makers, and industry) in the design of research and the monitoring system and in the development of practical recommendations emerging from the research and analysis in order to ensure that the project achieves its ultimate goal. In particular, an increased uptake of the most effective SCS and labels by the bio-based industry will support the development of circular, climate-neutral, sustainable biobased systems that will mitigate climate change, increase resource efficiency, preserve and restore ecosystems, biodiversity, natural resources, and the quality of air, water and soil.

Keywords: environmental protection social economic sustainability bio based products certification stakeholder engagement
DE-centralised Cloud labs fOr inDustrialisation of Energy materials (DECODE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Norway,France,Canada,Denmark,Switzerland,Netherlands,Spain
Call: Adaptive multi-scale modelling and characterisation suites from lab to production (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 6836306.75
EU funding (EUR): 6794831.75
Participants: 16
Project status: SIGNED

DECODE aims at creating and demonstrating a decentralised and adaptable future lab concept that connects multiple labs on a single platform in order to boost the effectiveness and speed-up the development and innovation path for clean energy materials and technologies. Initially demonstrated for selected hydrogen technologies, the DECODE platform is expected to find wide adoption in the clean technology field in the longer run, including energy harvesting, conversion and storage; clean water technologies; and the synthesis of value-added chemicals and fuels. The core of the platform comprises three elements: the DECODE FABRIC that connects adaptative multi-scale modelling and characterisation suites in a matrix-like structure; a scoring concept to assess modelling and characterisation suites in terms of their integration readiness level (IRL); and an AI-enabled central unit (CPU) that processes the IRL scores, performs the technology mapping to the FABRIC and orchestrates contributions in modelling and characterisation from partner labs. For the platform as a whole, DECODE strives to achieve a high level of flexibility, adaptability, and interoperability, in terms of materials modification strategies, technologies and operating regimes that it will be able to handle. Water electrolysis and hydrogen fuel cell technologies are selected for the demonstration of DECODE’s decentralised labs platform. The project will join leading expertise and capabilities in physical theory and modelling, design, fabrication, operando characterisation and testing of functional materials and components, materials digitalisation and cloud-connected lab operations, and industrial-grade component integration and in-line/end-of-line testing and validation by industrial partners in the consortium.

Keywords: clean technologies,green energy production,digital supply chain,correlative data analytics,tooling for diagnosis
Climate Adaptation and Resilience Demonstrated In the MEDiterranean region (CARDIMED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Greece,Netherlands,Italy,Spain,France,Portugal,Cyprus,Türkiye,Malta,Austria,Croatia,Germany,United Kingdom
Call: Testing and demonstrating transformative solutions on climate resilience, mainstreaming nature based solutions in the systemic transformation (HORIZON-MISS-2022-CLIMA-01, 2022)
Start date: 2023-09-01
End date: 2028-02-29
Duration (months): 54.0
Total project cost (EUR): 20807715.55
EU funding (EUR): 19307911.25
Participants: 56
Project status: SIGNED

CARDIMED will introduce a framework to build Climate Resilience in the Mediterranean biogeographical region, efficiently unifying individual efforts of regions and communities across different countries and continents. This will be achieved by deploying the digital infrastructure to harmonise the data collection and evaluation processes, providing open data to all the actors involved in the Nature-based Solutions (NBS) value chain and integrating crucial functions for Climate Resilience. Among these functions, smart digital tools for citizen participation and capacity building will supplement an ambitious multi-stakeholder engagement strategy, focused on knowledge translation and impact pathways. Furthermore, holistic modelling tools introducing the Water-Energy-Food-Ecosystems (WEFE) Nexus approach will provide comprehensive knowledge on the complex NBS interfaces, that will decisively contribute to addressing socio-ecological challenges, along with issues of valuation and low-investment rate in NBS. These actions will be implemented across 9 demonstration sites, composed of 10 regions, 20 locations and 28 communities and comprising 47 NBS that directly relate to 83 interventions and supporting units that tackle climate change and circularity challenges. The consolidation of the demonstrating regions and communities will establish the CARDIMED Resilience Alliance, that will function as the vehicle for expanding the network via upscaling the existing sites and adding new ones. The project includes 5 transferability cases, as well as an additional 10 that will be defined during the implementation. Through these actions, the CARDIMED Resilience Alliance will achieve at least 28 regions and 70 communities by 2030, will create 8000 jobs especially in the NBS sector, and will leverage over 450 M€ in climate investment.

Keywords: mediterranean biogeographical region,nexus,water energy food ecosystems,risk mitigation,social engagement,climate resilience,digital literacy,circular economy,water scarcity
Risk AssessmenT InnOvatioN for low-risk pesticides (RATION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Greece,Austria,Belgium,Israel,Bulgaria,Korea, Republic of,Germany,Poland,France,Spain,Italy,Netherlands
Call: Risk assessment of new low risk pesticides (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 6996623.75
EU funding (EUR): 6994748.0
Participants: 22
Project status: SIGNED

Low risk pesticides (LRP) including (i) plant extracts (ii) semiochemicals like pheromones and allelochemicals, (iii) microbial pesticides, are gaining ground in the global market, as substitutes of synthetic pesticides. In addition, new microbial solutions (phages, protists, microbial consortia) and ds-RNA pesticides are emerging, low-risk solutions expect to reach the market in coming years. Despite on-going regulatory efforts by the European Commission, we are still lacking a concrete risk assessment (RA) scheme relevant to LRPs, a point which blocks LRPs reaching the EU market. RATION timely comes to address these regulatory constraints and aims to develop a novel RA scheme, supported by the necessary guidance on methods and tools, tailored to the specific characteristics of established and emerging LRP solutions. This main goal will be achieved through a series of interrelated WPs aiming (i) to map the current status of LRPs in Europe and identify main regulatory constraints (WP1). In this quest it will be supported by a stakeholders forum composed of all relevant actors (industry, regulators, academics, famers, general public); (ii) to develop and validate, through a proof-of-concept exercise, innovative RA (and associated tools) for microbials (WP2), plant extracts, semiochemicals, pheromones (WP3) and, ds-RNA (WP4); and from there (iii) build a harmonized RA for all LRP and determine its socioeconomic impact (WP5), (iv) to effectively communicate and disseminate the new RA knowledge and its associated tools developed by RATION to relevant actors ensuring sustainability beyond project duration (WP6). RATION will benchmark EU regulatory science, uplift blockers holding back LRP uptake by the EU market and motivate research innovation in plant protection. To achieve these goals 22 partners from academia, industry and regulatory bodies, representing 10 member states and 2 non-EU member states, will join forces in a multi-sectoral and multi-disciplinary effort.

Keywords: microbiome and microbial pesticides,plant extracts,pheromones,semiochemicals,ds rna,risk assessment,stakeholders forum
Utilising the upgraded T2K near detector and developing water-based liquid scintillator technology towards a CP violation measurement in neutrinos (CPT2K2HK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-10
End date: 2027-09-09
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

The dominance of matter over antimatter in our universe is an unresolved question in our Standard Model of particle physics. Measuring Charge-Parity violation in neutrino oscillations at long-baseline neutrino experiments is crucial for understanding this phenomenon. The T2K experiment, which is currently operational, and its successor HyperKamiokande, beginning in 2027, are the most sensitive probes for measuring CP violation in neutrinos, and early hints of maximal violation have been published by T2K. There is a discovery potential with the data that will be taken in T2K over the course of this fellowship period if CP violation is indeed maximal, or with precision measurements to be performed using high statistics at HyperK. To achieve this in T2K its recently upgraded near detector, ND280, must be fully utilised, and for the high-statistics precision era in HyperK, further upgrades to ND280 will be needed. This project aims to characterise and maximise the performance of the upgraded ND280, using the state of the art Super Fine Grain detector and high-angle Time Projection Chambers that were installed with the final goal of reducing systematic uncertainties in neutrino measurements from ~6% to ~4%. The new detectors will be used to perform a measurement of the electron-neutrino cross-section to reduce this as a large systematic uncertainty contribution in CP violation measurements. This measurement will maximise CPV discovery potential in T2K, while the characterisation and methodology will be critical in HyperK to achieve a precision measurement faster. To reach systematic uncertainties below 3% in HyperK, research into using a large scale water-based liquid scintillator detector in ND280 will be undertaken, including building and characterising prototypes to then establish a sensitivity study for CP violation measurement in HyperK in the next decade.

Keywords: neutrinos flavour physics cp violation detector design scintillators
Network-based bioinformatics roadmaps bridging EBV-Host Imbalance to Disease Onset and Progression in Multiple Sclerosis (BEHIND-MS Hop-On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Cyprus
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 44.0
Total project cost (EUR): 447606.25
EU funding (EUR): 447606.25
Participants: 2
Project status: CLOSED

The main objectives of the initial BEHIND-MS project include the investigation of the immune system response to Epstein-Barr Virus (EBV) in the blood and brain and the detection of irregular immune activation due to EBV in people with Multiple Sclerosis (MS), the exploration of how EBV and the immune system can cause damage to the nerve cells in MS as well as the identification of MS onset and progression mechanisms and of new treatments. The BEHIND-MS Hop-on proposal aims to enhance the capabilities of the BEHIND-MS consortium with network-based integrative bioinformatics that will provide integrated roadmaps linking EBV-host imbalance to disease onset and progression in MS. The objectives towards this goal are: (1) to use scRNA-seq for the generation and analysis of cell-to-cell communication networks in blood and CSF in order to assess the interplay of the various immune cell types with the EBV-infected cells in MS and Healthy background, (2) to apply systems bioinformatics approaches to generate and analyze protein-protein interaction networks between virus proteins, host proteins and proteins related to MS pathology, (3) to incorporate the protein-protein interaction and gene regulation modules of the most significant players in the redox signalling pathways (4) to provide network-based pathway analysis and computational drug repurposing enabling better understanding of the underlying mechanisms and highlighting candidate repurposed drugs that may prevent MS onset or progression, (5) to build an integrative atlas representing a knowledge base with visual and interactive interface that will combine multi-level data measurements and a-priori knowledge regarding immune system, EBV infection and MS. The ambition of this hop-on proposal is to computationally generate high granularity roadmaps of cell-to-cell communication networks and protein-protein interaction networks that bridge EBV-host imbalance to disease onset and progression in multiple sclerosis.

Keywords: network based bioinformatics,cell to cell communication networks,integrative atlas,ebv host interactions,ebv ms relationship
Revolutionary silk-based bioink for 3D printing of ex vivo bone marrow models to advance drug development and personalized medicine (SILKink)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Sweden,Netherlands
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 2494687.5
EU funding (EUR): 2494687.5
Participants: 4
Project status: SIGNED

Aim: The SILKink project aims to develop a breakthrough biocompatible hydrogel, i.e., a bioink, to 3D print bone marrow tissue models that can be used for robust culture of human stem cells. The use of silk as the basis for novel bioinks (SILKink) helps to recreate tailored bone marrow-like microenvironments that will enable new applications in drug development and personalized medicine for bone marrow diseases. Here, we aim to optimize and validate SILKink, further define the business opportunity, and found an investment-ready spin-off company to commercialize SILKink. Unmet need: Bone marrow stem cells are fragile and require highly specific surroundings to survive and differentiate, therefore the presence of a soft tissue environment mimicking the human bone marrow is critical for reproducible culturing of these cells. There is a large unmet need for reproducible solutions that mimic the soft tissue of the bone marrow to allow advancements in drug development and personalized medicine approaches for bone marrow diseases. Solution: We will develop SILKink: a revolutionary bioink that is uniquely based on silk to closely mimic the 3D soft tissue environment of the bone marrow. SILKink will provide a matrix that supports all bone marrow cells including hematopoietic stem and progenitor cells and allows to 3D print ex vivo bone marrow stem cell models in the shape or volume desired. Consortium: University of Pavia (UNIPV) and partner CELLINK have developed the SILKink prototype during FET Open project SilkFUSION and co-own the background IP. Partner Catalyze-Group – Venture Building Team (CAT) will bring commercial expertise to develop an optimal market access strategy for SILKink. UNIPV will be responsible for SILKink optimization, manufacturing, and validation. CELLINK will be involved in product optimization and responsible for product development. CAT will assist UNIPV with founding a spin-off company to commercialize SILKink and making it investment-ready.

Keywords: 3d bioprinting,bioinks,silk biomaterials,haematopoietic stem cells,platelets,thrombocytopenia,erythrocytes,haematological diseases,drug testing,cancer,chemotherapy,bone marrow failure
Nitrogen Chemistry with Alkaline-Earth Metals (NITRO-EARTH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2025-10-31
Duration (months): 41.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: TERMINATED

NITRO-EARTH is aiming to investigate the hardly explored nitrogen chemistry of the alkaline-earth metals (Ae) in order to disclose new reactivity and catalysis. In the biogeochemical nitrogen cycle oxidized (NOx), neutral (N2) and reduced (NH3) forms of N are interconverted by a complicated network of processes. In contrast, manipulation of N in industry is challenging and often needs brute-force methods. The Haber-Bosch process for N2-to-NH3 conversion is, despite being metal-catalysed, one of the most energy consuming industrial processes. This proposal focusses on the organometallic chemistry of imido [RN(2ˉ)] and nitrido [N(3ˉ)] complexes of the alkaline-earth metals, in particular Mg and Ca. While the amide (R2Nˉ) chemistry of the Ae metals is well-established, Ae-imido complexes are rare and Ae-nitrido compounds solely exist as insoluble salts, e.g. Mg3N2. Given the importance of imido and nitrido ligands in transition metal chemistry, access to soluble Ae=NR and Ae≡N complexes promises a rich reactivity and is the prelude of new catalytic processes based on abundant, generally biocompatible, alkaline-earth metals. The various pathways to reach the target include utilization of recently introduced, highly reducing Mg(0) complexes by HARDER and nitreones which have been investigated by PATEL. Also HARDER’s recently discovered N2 fixation with Ca will play a role in the synthetic approach. Owing to the highly ionic character and negative charge on N in Ae=NR or Ae≡N complexes, these novel complexes will be extremely potent nucleophiles or deprotonating reagents. This will be strongly dependent on nuclearity and aggregation which will be controlled by a library of bulky ligands currently available in the HARDER group. The work will be heavily supported by ab initio calculations. The project ultimately leads to the generation of a new class of alkaline-earth metal catalysts which may provide sustainable alternative for transition metal based catalysts.

Keywords: early main group metals,alkaline earth metals,imido and nitrido complexes,sustainability,low valent complexes