Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Electron beams enhancing analytical microscopy (EBEAM)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Belgium,France,Netherlands,Netherlands,Netherlands
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2026-03-31
Duration (months): 63.0
Total project cost (EUR): 5045530.0
EU funding (EUR): 5045530.0
Participants: 8
Project status: SIGNED

Electron microscopy (EM) is a key technology to reveal the atomic structure and chemical composition of materials with (sub-)Ångström resolution. It is an essential technique to enable the breakthroughs that are needed to solve societal challenges in renewable energy technology, life sciences, and communication and quantum technology. To realize these breakthroughs, we require EM technology with ultrafast time scale, ultrahigh energy resolution, covering low-energy spectral ranges and several other capabilities, all of which are beyond the present state of the art. The EBEAM project brings together a proven consortium of EM experts that will integrate their complementary EM science and technology into completely new EM measurement modalities, exploiting the unique interactions between free electrons and optical light fields, and thereby combining ultrahigh spectral and temporal control with sub-Ångström spatial resolution. The project’s ambition is to demonstrate <20 fs time resolution and <1 meV energy resolution, and to open up the 4-400 neV (1-100 MHz) energy range, all inaccessible in EM so far. Using new correlation and coincidence modalities that have never been used in EM before, we will unveil new methods to probe selection rules, low-energy band structures, trace elements, and more. We will demonstrate the broad applicability of the new EBEAM techniques by carrying out selected research projects that target key questions in energy conversion materials, opto-electronic materials and quantum technology. The consortium is composed of 8 EM groups in basic research and industry that represent a unique combination of EM instruments, knowledge and ideas that are well positioned to target the ambitious goals of the EBEAM project. It includes the world-leader in EM manufacturing and a successful SME. Together, the consortium will bring the EBEAM technology to a broad user community where it is expected to have strong scientific and economic impact.

Keywords: electron microscopy,materials analysis
Understanding molecular principles of regulated mRNA degradation on translating ribosomes (mRNA-DEG-RIBOSOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Cell tightly regulate mRNA processing, localisation and stability to ensure accurate gene expression in diverse cellular states and conditions. Most of these mRNA regulation steps have traditionally been thought to primarily happen before translation. However, recent discoveries highlight the role of nascent polypeptides on translating ribosomes in the active regulation of mRNAs. As the nascent protein emerges from the ribosome, it marks the identity of the encoding mRNA by its unique amino acid sequence. This allows cotranslational engagement by specific polypeptide recognition factors on the ribosome, providing them access to the associated mRNA. A striking example for such regulation is the negative feedback loop in the expression of tubulins known as “tubulin autoregulation”. In this case, tubulin mRNA is degraded cotranslationally when cells sense excess free tubulin, which is critical during mitosis to ensure faithful chromosome segregation. Recently, the first specific factor in this pathway has been identified: TTC5 recognises the N-terminus of nascent tubulin emerging from the translating ribosome and triggers degradation of the associated mRNA. However, the events leading to tubulin mRNA decay downstream of TTC5 remain elusive. In mRNA-DEG-RIBOSOME I will use tubulin autoregulation as a model system to study how the nascent chain on translating ribosomes directs mRNA degradation. Specifically, I aim to: (1) identify factors acting downstream of TTC5 required for tubulin mRNA degradation using cutting-edge mass spectrometry and genetic screening methods; (2) understand the mechanistic role of each factor in TTC5-directed mRNA degradation by using a powerful in vitro reconstitution approach; and (3) expand the understanding of nascent chain-dependent mRNA degradation by investigating related feedback systems. Thus, my work will to provide a conceptual framework for how cells have evolved to exploit nascent polypeptide recognition to direct mRNA fate.

Keywords: mrna degradation,nucleases,ribosome associated quality control,gene expression control,tubulin regulation
Advanced Eco-designed Fibres and Films for large consumer products from biobased polyamides and polyesters in a circular EConomy perspecTIVE (EFFECTIVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Germany,Italy,Italy,Italy,Spain,Italy,Slovenia,Croatia,Sweden,Croatia,France,United States
Call: Advanced bio-based fibres and materials for large-volume applications (H2020-BBI-JTI-2017, 2017)
Start date: 2018-06-01
End date: 2023-02-28
Duration (months): 57.0
Total project cost (EUR): 11790447.58
EU funding (EUR): 7171906.64
Participants: 16
Project status: CLOSED

The EFFECTIVE project intends to demonstrate first of its kind and economically viable routes for the production of biobased polyamides and polyesters from sustainable renewable feedstock for the obtaining of fibres and films with enhanced properties, market competitiveness and increased sustainability. Such materials will be applied into eco-designed large consumer products targeting different markets, i.e. construction, automotive, primary and secondary packaging and textile and with the potential of being applied into many other markets (fishing, engineering plastics, agriculture, hygiene and personal care). Following a circular economy approach, the sustainability of the value chains will be further enhanced by the demonstration of an improved end-of-life of the developed eco-designed biobased solutions through the application of monomer regeneration, recycling (for polyamides based fibres and films) and composting/anaerobic digestion (for polyesters based films) processes. The idea that “the end is a new beginning” will indeed drive the products design and realization. The project covers the whole value chain: feedstock production, conversion into innovative biobased building blocks through biotechnological and chemical processes, formulation of innovative biobased polymers (polyesters and polyamides), final products development, end-of-life products management and processing. The project intends to represent a key milestone towards the future industrialization of biobased fibres and films production in Europe foreseeing the mobilization of relevant investments by involved industry partners and fostering the adoption of multi-stakeholders collaboration models to demonstrate effective ways to develop new cases of biobased economy interconnected with circular regenerative economy joining environmental sustainability and economic profitability.

Keywords: biobased caprolactam,azelaic acid,long chain dicarboxylic acids,polyamides,polyesters,eco design,large consumer products,regeneration,recycling,composting,biobased economy,circular economy
An eco-innovative planting and survival support system for urban trees (TREEPAD)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Germany
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Harsh urban growing conditions have caused the vitality of urban trees to fall drastically during the last 30 - 40 years . Urban tree mortality is the highest among the youngest trees, especially in the first two to three years after transplanting which results in enormous costs for replanting. In parallel, the market is steadily increasing, European cities and municipalities are planning to plant around 200 million trees in the next 25 years. In order to use this market opportunity, our company, LORBERG has successfully developed TREEPAD, an innovative and cost-effective, all-in-one survival support system for urban trees. TREEPAD will ensure an easy and fast planting process and high survival rate even years after transplantation by addressing the three main problems of newly transplanted trees: anchoring, water supply, and a balanced nutrient supply. In addition, TREEPAD is able to communicate its water supply status to the client. TREEPAD consists of a semi-flexible sheet of slow biodegradable, bio-based polymers (i.e. polylactic acid blends, or poly-3hydrohybutyrate) with anchoring spots, which will attach to the burlap sack that contains the roots, providing the stability required by the tree to thrive in its new location. Furthermore, the biopolymer sheet contains pockets filled with hydrogel, which will be loaded with water upon plantation and will release it slowly after planting. In addition, specific nutrient mixes will be added to the hydrogel, which will release them also during the liberation of water to achieve a fertilization effect. The results obtained by us during the development phase indicate that TREEPAD would boost the survival rate to at least a 95% of planted urban trees and will reduce the planting cost and time needed by 80%.

Keywords: tree mortality,irrigation,anchoring,fertilisation
Contextualizing Evidence for Action on Diabetes in low-resource Settings: A mixed-methods case study in Quito and Esmeraldas, Ecuador. (CEAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Spain,Ecuador
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-09-30
Duration (months): 69.0
Total project cost (EUR): 1475334.0
EU funding (EUR): 1245634.0
Participants: 2
Project status: SIGNED

The relentless rise in diabetes is one of the greatest global health emergencies of the 21st century. The increase is most pronounced in low and middle income countries where today three quarters of people with diabetes live and over 80% of the deaths attributed to non-communicable diseases occur. In light of the wealth of knowledge already available about how to tackle the problem, most major international organizations call for the adoption healthy public policies and initiatives to strengthening health systems. However, implementation of recommended action remains limited in many settings. Most evidence comes from high-income settings and may generate recommendations that cannot be successfully implemented in other settings without careful consideration and contextualization. I propose here that this “know-do” gap can be reduced by revealing the barriers to implementing evidence-based recommendations, engaging local stakeholders in developing context-led innovations and developing a tool-kit for contextualizing and implementing diabetes recommendations in low-resource settings. I plan the research in two carefully selected settings in Ecuador, with mixed-methods combining quantitative epidemiological research and qualitative methodology to generate the rich and varied knowledge that is required to trigger policy action and/or changes in care models. Furthermore, I will engage patients, community members, health workers and decision makers in the process of knowledge generation, interpretation and use. The overarching objective is hence, to explore the process by which global recommendations can be translated into context-specific, evidence-informed action for diabetes prevention in low-resource settings. The findings will support the global endeavour to bridge the global “know-do” gap, one of the most important public health challenges this century and a great opportunity for strengthening health systems and achieving health equity.

Keywords: type 2 diabetes,global health challenges,implementation science,population engagement in knowledge generation
Operando study of the catalytic activity of gold nanoparticles by Surface Differential Reflectivity Spectroscopy (SDRS): from plasmonic response to morphology (OSCAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-31
End date: 2018-03-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 2
Project status: CLOSED

The outstanding catalytic activity of gold nanoparticles (NPs) on metal-oxide supports has attracted enormous interest not only for fundamental understanding but also for the design and synthesis of a new generation of efficient catalysts. At the current time, one of the main technical challenges for gold catalyst applications is the stability in terms of sintering during use. As for many heterogeneous catalysts, the characterization of the gold NPs morphology in operating conditions is essential for progress towards practical use. The issue is currently treated by X-ray diffraction at synchrotron radiation facilities. The present project (OSCAR) foresees a breakthrough. It aims to develop an optical method, namely Surface Differential Reflectivity Spectroscopy (SDRS), to determine operando at the laboratory the shape and size of NPs on the basis of their plasmonic response. The challenge is to combine non-invasive SDRS measurements for determining NP morphology to reactivity measurements in realistic conditions. The case study is the archetypal case of CO oxidation on supported gold NPs, for which the relationship between NPs size/shape and reactivity is vividly debated. The catalytic activity of gold NPs will be examined both on a reducible substrate, rutile TiO2(110), and on an irreducible substrate, MgO(100) films on Ag(100), to determine the crucial role played by the supporting metal-oxide substrate.

Keywords: operando surface differential reflectivity spectroscopy,gold nanoparticles,metal oxide interfaces,catalysis,scanning tunneling microscopy,photoemission spectroscopy
KIOS Research Center of Excellence for Intelligent Systems and Networks (KIOS CoE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Framework Partnership Agreement
Countries involved: Cyprus,United Kingdom
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-05-04
End date: 2020-05-03
Duration (months): 60.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 2
Project status: CLOSED

The aim of the proposed TEAMING project is to develop the KIOS Research Center of Excellence for Intelligent Systems and Networks, an inspiring environment for conducting basic and applied research and innovation in the area of intelligent monitoring, management and security of critical infrastructure systems. The proposal is a team effort between the University of Cyprus and Imperial College London. The technical focus of the proposed Center of Excellence is a key technological area of significant growth potential. The strong background and individual experience of the University of Cyprus and Imperial College London in the area of intelligent monitoring, management and security, combined with the synergy created by the TEAMING proposal, provides a great opportunity for establishing a sustainable Center of Excellence, which will address crucial research and innovation problems of great societal benefit. The application of information and communication technologies (ICT) to critical infrastructure systems is completely aligned with the Cyprus Smart Specialization Strategy. The proposed Center of Excellence will create new job opportunities in the high-tech arena and will attract new researchers to Cyprus, thereby creating a sustainable critical mass of researchers that can address challenging scientific and technological problems. The TEAMING project will provide a significant boost towards the long-term sustainability of the Center through establishing long-term framework agreements with top academic institutions worldwide, via the generation of intellectual property rights and through the exploitation of the research results. Moreover, the proposed Center of Excellence will promote opportunities for collaboration between industry, academia and research organizations in technology areas of importance to Europe.

Keywords: intelligent control,computational intelligence,fault diagnosis,control engineering,smart infrastructure
Structure in the Primes, with applications (PRIMES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-07-31
Duration (months): 66.0
Total project cost (EUR): 1489402.0
EU funding (EUR): 1489402.0
Participants: 1
Project status: SIGNED

Questions about prime numbers make up several of the oldest and most important open problems in mathematics. Unfortunately our techniques for solving these problems are very limited; even some of the most basic and simple to state questions about primes are well beyond current techniques. This project studies several different questions related to the distribution of the primes, with the aim of developing new flexible techniques for studying the primes in general. Such new techniques would then give insight to the fundamental problems at the heart of the subject. The only general approach we have to counting primes is via variants of ‘Type I’ and ‘Type II’ arithmetic information. There have been several remarkable developments in sieve methods in recent years, which have greatly enhanced the utility of Type I information. Without establishing some sort of Type II information, however, it seems unlikely that one can fully solve the most important problems in the subject. This proposal seeks to develop both our Type I techniques and our Type II techniques, as well as the interactions between them. A common theme throughout the proposal is to identify and classify potential obstructions to traditional methods, and then overcome these obstructions using a combinations of new ideas. Often these new ideas will come from other areas of mathematics, such as combinatorics, geometry, probability, automorphic forms or harmonic analysis. This approach has already led to significant advances in our understanding of primes in recent years, most notably in the gaps between primes. The proposal is based around several intermediate problems for developing these connections further, giving opportunities for proof-of-concept results of such new ideas overcoming old barriers.
CellProbe: Microfluidic probe for simultaneous tagging and extraction of single cells (CellProbe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-04-01
End date: 2020-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Having developed a liquid scanning probe - microfluidic probe (MFP) - for creating spatially-defined microscale biochemical environments and microscale molecular assays within the ERC-BioProbe project, in this proof-of-concept project, - CellProbe - we seek to leverage this technology toward realization of a commercially viable single-cell analysis platform

Keywords: single cell analysis,spatial heterogeneity,microfluidics,multimodal analysis,liquid scanning probes