Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The geometry of chromatic categories (ChromoCats)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

This project studies the local and global structure of fundamental categories in topology, algebra, and algebraic geometry from a geometric point of view. Deep structural results have been proven in special cases, but the lack of a unified theory has prevented progress on several key conjectures, for example pertaining to local-to-global principles. In a first step, we introduce the concept of chromatic category, which axiomatizes certain properties found on the derived category of quasi-coherent sheaves on a scheme or stack. Important examples of chromatic categories include the category of spectra in stable homotopy theory and the stable module category for a finite group. The resulting framework allows us to transfer tools and questions from one context to another, thereby shedding light on three key aspects of the geometry of a chromatic category: Its local structure, local-to-global principles, and compactifications. In a second step, we study these three interrelated aspects in detail. The local structure of a chromatic category is controlled by its local Picard groups, which give new and subtle invariants in modular representation theory. We then gain new insights about the structure of these groups via local duality and a profinite extension of the theory of ambidexterity due to Hopkins and Lurie. Moreover, local-to-global principles like the chromatic splitting conjecture, blueshift, or redshift are shown to be governed by a generalization of Tate cohomology, for which we introduce powerful new tools of computation with applications to various Balmer spectra. Finally, we construct compactifications of chromatic categories via a categorification of ultraproducts from mathematical logic. This solves the algebraization problem in chromatic homotopy. In conclusion, the outcome of this project is a framework that systematically describes the geometry of chromatic categories, leading to substantial progress on outstanding conjectures in algebra and topology.

Keywords: chromatic homotopy theory,stable module category,balmer spectrum,picard groups,chromatic splitting conjecture,blueshift,local duality,tate construction,compact groups,ultraproducts
Empowering citizens to make meaningful use of open data (Open4Citizens)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Sweden,Netherlands,Denmark,Denmark
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-06-30
Duration (months): 30.0
Total project cost (EUR): 1999411.25
EU funding (EUR): 1999411.25
Participants: 8
Project status: CLOSED

The project aims at shows the potential of open data to citizens, by creating open playgrounds where citizens, students, experts, start up companies, academia and public institutions can collaborate to generate meaningful applications. Thus, applications that meet citizens' needs and desires and contribute to their everyday life. The playground is a virtual and physical place where citizens, interest groups, movements can find a reference to generate new solutions. Likewise fablabs, which are disclosing new opportunities for bottom-up production by manipulating materials, the O4C playgrounds disclose new opportunities in re-using open data. The playgrounds are defined through a series of hackathons involving several stakeholders, including citizens, communities, grassroots groups, students, start-up companies and representatives from public institutions or service providers. Together they work on hackathon cycles, to co-create new solutions for existing or future services based on the use of data. These include but are not limited to the data coming from the existing networks of devices, sensors and microcomputers part of our city infrastructures, and the user-generated data deriving from the citizens’ voluntary publication of information, positioning data or other personal data. The outcome of the project is therefore the conceptual definition and methodological underpinnings of the O4C playground, and a proof of concept consisting of the innovative solutions generated in the hackathons. The O4C playground is not just a place (the O4C lab) or an event (the hackathon), but an integrated system of engagement, participation and co-design tools that will support the cooperation between the various stakeholders. The social impact of this project does not just lay on the individual solutions developed at the hackathons, but also in the reduced distance between open data and citizens: increasingly data are available and more citizens are empowered to use them.

Keywords: open data
UAV ENGINEER FOR OPTIMISATION OF FIREFIGHTING DRONE STABILISATION (HOPPERSUP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2020-02, 2020)
Start date: 2020-10-15
End date: 2022-03-14
Duration (months): 17.0
Total project cost (EUR): 136607.14
EU funding (EUR): 95625.0
Participants: 1
Project status: CLOSED

DRONE HOPPER is a technological start-up founded in 2015 and devoted to the design, production and operation of drones or Unmanned Air Vehicles (UAV) for firefighting. Drones have the potential to overcome the limitations of helicopters and hydroplanes in firefighting, as no lives would be put at risks even during night operations and offering the possibility to fly at low altitudes to improve effectiveness. However, nowadays the use of drones in fires is limited to monitoring, surveillance and data collection tasks because current drone technologies based on electrical systems lack the necessary power to lift heavy loads. DRONE HOPPER has developed and validated heavy duty commercial drones, designed for transport of heavy loads (high water volumes) and with a patented system for spraying liquids increasing the effective coverage area of the intervention. This technology enables that our drones have an excellent potential to disrupt the market for unmanned firefighting. Nevertheless, we need to evolve the attitude control and stabilisation system to reach the required robustness and reliability of operations. This project is aimed to fill a job vacancy for an UAV engineer to join our R&D team as an Innovation Associate, with an extendable 1-year duration contract and reporting directly to our CTO. The profile of the Associate is a PhD researcher with experience in the development of flight control systems for rotatory wing UAVs, either helicopters or multi-rotors. The Associate will assume a leading role in the development, implementation and testing of an enhanced stabilisation control system for our drone platform, with the overall objective of contributing to increase the UAV´s payload capacity from current 150L to 600L.

Keywords: multi rotor unmanned aerial vehicles,drone stabilisation control,drones for multiple aerial works
Understanding the impact of DNA demethylation in Motor Neuron Disorders (MANTIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-10-20
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

Motor neuron disorders (MND) are a spectrum of devastating diseases caused by motor neuron (MN) cell death. Recent findings revealed that DNA methylation is a hallmark of MN cell death. However, the cause and affected mechanisms leading to methylation increase remain mostly unknown, therefore limiting the design of therapeutic intervention. The discovery of a novel DNA modification has provided a paradigm shift in the understanding of DNA methylation and demethylation regulatory network. In fact, methylated cytosines (5mC) can be converted to hydroxymethylated cytosines (5hmC) by Ten-eleven-translocation (TET) enzyme family. 5hmC is found to be stably present in DNA and to influence gene expression as an epigenetic mark independent of 5mC. My preliminary experiments showed that MN death in a severe mouse model of Spinal Muscular Atrophy (SMA) is correlated to a genome-wide increase in 5mC levels and loss of 5hmC. This research proposal therefore aims to define the role of 5hmC and the TET family of enzymes in controlling MN pathophysiology. To address the common role of DNA demethylation loss in MND, I will investigate the methylation mechanism in SMA and another MND- Amyotrophic lateral sclerosis (ALS). The specific aims of this project are to (1) define the exact profile of 5mC and 5hmC in regulating gene expression in SMA and ALS via a genome-wide reduced representation sequencing; (2) test whether TETs interact with the Survival of Motor Neuron (SMN1) protein that is responsible for MNs cell death in SMA; (3) establish the therapeutic potential of a locus-specific demethylation in promoting restoration of the diseased epigenetic profile using the Crispr/Cas9 technology. These studies will greatly advance the understanding of the epigenetic regulation of MN cell death by 5hmC and TET proteins, and will set the stage for testing the therapeutic potential of these novel regulators in MNs disorders.

Keywords: motor neuron,5hmc,ten eleven translocation,dna methylation,dna demethylation,dna hydroxymethylation,spinal muscular atrophy,amyothrophic lateral sclerosis,survival of motor neuron smn
NEXT GENERATION TOPICAL MEDICATION TO TREAT IMMUNE RESPONSES IN ATOPIC DERMATITIS – THE MOST COMMON CAUSE OF ECZEMA (TIR-C)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TIRmed pharma AB has developed a non-steroid cream that relives itch in Atopic Dermatitis (AD). Itch is an enormous, unresolved symptom in AD, induced by inflammation and skin damage. AD poses a significant burden on societies and patients’ quality of life due to itch, infected lesions, sleep deprivation, and consequently productivity loss, psychological health and treatment-associated expenditures. Persons affected by AD consistently rate AD management to be comparable to diabetes management. Our TIR-C cream doesn’t contain steroids and works through an entirely novel mechanism of action. The therapy has been developed with the largest patient group in mind; children. TIR-C has the potential to become a blockbuster in AD management as it has an excellent safety profile, is very affordable, is easy to self-apply (water-based), doesn’t interfere with vital immune defences and has the potential to prevent disease escalation. We target mild-to-moderate symptoms (80% of all AD sufferers), aiming to eliminate the need for intravenously administrated biologics. Biologics are not only extremely costly, but also associated with severe side effects, making them unsuitable for children. The unmet need for safe, topical anti-itch-treatment in persons with mild-to-moderate AD has been clearly communicated by leading contract research organizations, KOLs and clinicians within dermatology. TIR-C is at Technology Readiness Level 4 with established manufacturing and formulation processes and a clinical development plan drafted in collaboration with a leading CRO in dermatology. The proposed feasibility study will advance preparations for commercialisation by allowing us to confirm regulatory requirements needed for market approvals, validate pricing through a health-economic survey in the EU, identify a local CRO to conduct the planned phase I/IIa clinical trials and confirm Freedom to Operate.

Keywords: atopic dermatitis,eczema,itch,atopic march
Upscaling and Market Introduction of Simultaneous Biogas Upgrading and Bio-Succinic Acid Production (NEOSUCCESS)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Spain,Greece,Denmark
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 2441266.25
EU funding (EUR): 1916280.48
Participants: 5
Project status: SIGNED

Succinic Acid (SA) is the most important multifunctional platform chemical for the industry with immense applications (bioplastics, polyurethanes, paints, etc.) but 95% of its production is petroleum-based. On a separate matter, biogas’ most valuable compound is BioMethane (BioM), used as renewable energy; but obtained by costly upgrading technologies, not fully widespread. Currently, the SA and BioM production are separate industrial processes. We have developed NEOSUCCESS, the first technology worldwide that recycles and uses residual waste streams to simultaneously produce these two high-value added products: BioM (>95%) from biogas to be used as a biofuel; and BioSA (>80%), a second-generation non-fossil alternative to SA. This is the first revolutionary biogas upgrading technology that binds CO2 into a valuable biochemical; highly reducing production costs and environmental footprint. The aim of NEOSUCCESS project is to make commercially available a unique technology based on a containerised plugand- play technology conceived to be integrated in biogas plants’ operational workflow, finally making the investment on biogas upgrading profitable as a result of its complementary BioSA exploitation. Our Consortium is formed by two well-established engineering firms and two world-class universities situated at the forefront of technical innovations. We have validated and patented a prototype from real sugar-rich waste side streams (41.5 L of fermentation broth); and now, we are highly skilled to build and fine-tune the first NEOSUCCESS industrial unit (capacity of 12,000 Nm3 of BioM and 47,000 kg of BioSA). Both Biogas Upgrading and BioSA markets have a double-digit growth, which strikes as a great opportunity for Europe to take a leap forward. Thanks to this project, we will achieve a successful market launch by 2023 and install 40 NEOSUCCESS units in 11 countries by 2027, contributing to the European transition towards a sustainable Bio-based Economy.

Keywords: biomethane,upgraded biogas,biosuccinic acid,chemical building block,bioeconomy,biogas plant,anaerobic digester,organic waste management,agri food industry
AMBER - enhAnced Mobile BiomEtRics (AMBER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Italy,Poland,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 2505152.16
EU funding (EUR): 2505152.16
Participants: 5
Project status: CLOSED

Over recent years the ubiquity of mobile platforms such as smartphones and tablets devices has rapidly increased. These devices provide a range of untethered interaction unimaginable a decade previously. With this ability to interact with services and individuals comes the need to accurately authenticate the identity of the person requesting the transaction many of which carry financial/legally-binding instruction. Biometric solutions have also seen increased prominence over the past decade with large-scale implementations in areas such as passport and national ID systems. The adoption of specific biometric sensors by mobile vendors indicates a long-term strategy as a means of authentication. This adoption is is at critical point – users need to be confident of biometrics in terms of usability, privacy and performance; compromise in any one of these categories will lead to mistrust and a reluctance to adopt over and above conventional forms of authentication. The design, implementation and assessment of biometrics on mobile devices therefore requires a range of solutions to aid initial and continued adoption. The EU needs to have experts trained specifically in the field to ensure that it participates, competes and succeeds in the global market. AMBER comprises 11 partners with recognised expertise from across the EU. The specific objectives are to: • Address a range of current issues facing biometric solutions on mobile devices requiring timely research and development. • Collate Europe-wide complementary expertise to investigate these issues and provide a structure and environment to effectively facilitate training. • Train and equip the next generation of researchers to define, investigate and implement solutions, and provide transferable skills to enable effective planning, management and communication of research ideas and outcomes. • Develop solutions and theory to ensure secure, ubiquitous and efficient authentication whilst protecting privacy of citizen.

Keywords: mobile platforms,usability performance,privacy,security and confidence
Accessory Genome Accountability in Pseudomonas aeruginosa Persistent Infections (AGAPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

Bacterial survival to antibiotic treatment poses an urgent problem to humanity, causing 25.000 deaths per year in the European Union alone. The inability to fully eradicate pathogens with antibiotics leads to the establishment of persistent infections (PIs). Pseudomonas aeruginosa, an opportunistic pathogen, is found chronically in the airways of 70% of Cystic Fibrosis (CF) patients. In CF, the anomalous production of mucus in the lung promotes the establishment of bacteria, with infections decreasing the life quality and expectancy of patients. The mechanisms by which P. aeruginosa is able to escape treatment and generate PIs within the CF lung have not been fully elucidated. Mostly, the success of P. aeruginosa relies on its adaptability, which derives from its large genome carrying genes for survival in a wide spectrum of environments. Most of these genes are not conserved among strains, composing the accessory genome (AG), which is built up through horizontal gene transfer (HGT). Previous studies have identified components of the AG involved in virulence and resistance, yet the extent of the AG involvement in PIs is unknown. Through AGAPE I seek to elucidate the relevance of the AG in the establishment of PIs in CF lungs. I will do so by studying both the conformation and function of the AG, through novel CRISPR-Cas tools in P. aeruginosa. First, I will determine the identity and quantity of HGT during infection by recording transfer events with a CRISPR-Cas recorder system. Second, I will generate individual and combinatorial knockdowns of every accessory gene through CRISPR interference (CRISPRi), to screen the effects of the repression on fitness during infection. I will follow the infections of the generated strains on lung organoids derived from the corresponding hosts. Overall, this bona fide action will allow to uncover novel mechanisms behind PIs relying on accessory genes, and to identify novel markers and targets to improve patient treatment.

Keywords: pseudomonas aeruginosa,pathogenesis,persistent infections,cystic fibrosis,crispr cas
ECOsystem services for resilient and sustainable cities: an ecohydrological approach for Green Urban Spaces (ECO.G.U.S.)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-15
End date: 2018-11-14
Duration (months): 27.0
Total project cost (EUR): 197720.1
EU funding (EUR): 197720.1
Participants: 2
Project status: CLOSED

For the first time in recorded history the majority of people live in cities and the increasing urbanization modifies their mass, momentum, and energy budgets: in the next decades redevelopment, densification, population increase and demographic shift, as well as climate change will potentially impact the production and consumption of urban ecosystem services. Among the various ecosystem services the ECO.G.U.S. proposal focuses on Green Urban Spaces (GUS). Under the framework of socio-ecohydrology, the ECO.G.U.S. project main goal is to develop scientific tools to quantify the GUS sustainability and their benefits as ecosystem services. The proposed scientific tools will generate guidelines and best management practices with the aim of improving the GUS quality and quantity as well as the current management practices. To address the aforementioned challenges, the objectives of the project are: • to perform a SWOT analysis of GUS typologies with respect to the urban water cycle components, including biophysical, structural and social factors; • to introduce a new dynamical ecohydrological model coupling the dynamics of water, vegetation, energy and nutrients in an urban environment with the stochastic components, thresholds and nonlinearities associated to unpredictability of the hydrological drivers and to the stronger human feedbacks on the hydrosphere and ecosystems; • to frame the problem of urban water management in GUS management using the theory of optimal stochastic control; • to define new guidelines for GUS management; • to lay the foundations of the first EU research group in urban ecohydrology. ECO.G.U.S. project represents one of the first applications of the stochastic ecohydrological approach and the optimal stochastic control to an urban context. The cooperation between high-level institutions (POLITO and DUKE) will help EU and US urban regions to better deal with the shocks and bombshells that will result from climate changes in the next futur

Keywords: ecohydrology,green urban spaces,ecosystem services,mathematical model,best practices,nonlinear dynamical eco hydrological model,optimal stochastic control