Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development and demonstration of a long-endurance sea surveying autonomous unmanned vehicle with gliding capability powered by hydrogen fuel cell (ENDURUNS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Cyprus,Lithuania,Korea, Republic of,Greece,Belgium,Lithuania,Greece,France,United Kingdom,Denmark
Call: Unmanned and autonomous survey activities at sea: (H2020-MG-2018-SingleStage-INEA, 2018)
Start date: 2018-11-01
End date: 2023-07-31
Duration (months): 57.0
Total project cost (EUR): 8747765.0
EU funding (EUR): 7908265.0
Participants: 18
Project status: SIGNED

Battery-powered AUVs have been used to study the seabed without the requirement of a human operator. Their operational endurance is limited by the available battery charge. Gliders, an AUV subclass, use small changes in their buoyancy to move like a profiling float. By using their wings, gliders can convert the vertical motion to horizontal, propelling themselves forward with very low power consumption. Hence, mission duration can be extended to months and to thousands of kilometers. However, gliders are suited for a particular set of missions involving relatively basic measurements and seabed mapping cannot be performed due to their inherent inability to cruise in a straight line. A surface support vessel is standard practice for launch and recovery of AUVs. The requirement to have a support vessel adds to the overall mission cost. Therefore higher endurance is needed in AUV platforms in order to bring mission costs down and improve the ocean exploration capability. The ENDURUNS project will deliver a step-change in AUV technology by implementing a novel hybrid design power by hydrogen fuel cell. An Unmanned Surface Vehicle (USV) will support the operation of the AUV, providing geotagging and data transmission capability to and from the Control Centre on shore.

Keywords: automated underwater vehicle,unmanned surface vessel,hydrogen fuel cell,hydrogen storage devices,seabed mapping,offshore infrastructure,inspection,navigation,control,docking
Multidisciplinary Training in Chronic Kidney Disease: from genetic modifiers to drug discovery (TrainCKDis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Italy,Italy,Switzerland,Sweden,France,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 4017848.4
EU funding (EUR): 4017848.4
Participants: 11
Project status: SIGNED

Chronic kidney disease (CKD) is recognized as an increasing global health problem. It currently affects 10-15% of the worldwide population, is associated with impaired quality of life and reduced life expectancy, and represents a significant burden for health care budgets. CKD is characterized by the progressive decline of renal function. Little is known about the mechanisms underlying this progression and the genetic factors that predispose patients to different rate of progression. Even worse, there is no reliable biomarkers capable to identify patients at risk of fast progression and treatments able to halt CKD progression. Understanding the physiopathology of CKD is therefore a prerequisite for the development of efficient preventive strategies and diagnostic tools. With this goal in mind, TrainCKDis will provide an innovative, multidisciplinary, and intersectoral training programme, able to prepare top-level young scientists to develop creative solutions for CKD. The proposed 15 research projects will address key challenges: i) the identification of genetic and epigenetic modifiers that predispose patients to CKD progression, ii) the identification of pathways and biomarkers for monitoring CKD progression and iii) the identification of novel therapeutic targets to improve the limited treatments for CKD. TrainCKDis gathers top European laboratories, companies, hospitals, and associations involved in the treatment of CKD. Early Stage Researchers (ESRs) will thus benefit from an outstanding interdisciplinary platform integrating nephrology, epidemiology, genetics, cell biology, high-throughput screening, system biology, and metabolomics experts, as well as experimental animal models and unique human biobanks. Moreover, ESRs will be trained in disseminating results through modern channels of communication. Finally, TrainCKDis will provide ESRs with intersectoral and transferable training for efficient career development in both the academic and private sectors.

Keywords: nephrology,chronic kidney disease ckd,modifiers genes,epigenetics,biomarkers,therapeutic targets,metabolomics,transcriptomics,system biology,hnf1b,tgf a,hif 1f,uromodulin,angii
Innovative 3-dimensional optoacoustic imaging for safe breast cancer screening (LOUISA 3D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-04-01
End date: 2019-08-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Breast cancer is a global challenge representing the leading cause of death for women worldwide: according to the estimates of WHO, there were over 2 million new cases in 2018, with a projection of more than 3 million individuals by 2040. It is usually diagnosed at an advanced stage while early detection greatly increases the chances for successful treatment. The 2 components of early detection are mass screening and early diagnosis. Currently, most diffuse population-based screening programs for breast cancer are based on mammography. Weighing the harms against the benefits of these programs has led WHO not to recommend mammography screening in women less than 50 years of age. Mammography has been the medical industry’s “gold standard” breast cancer screening tool for nearly four decades. Today a number of adverse effects, backed up by mounting scientific evidence, are limiting the use of mammography as a mass screening device. LOUISA-3D uses safe light and sound to provide safer and accurate breast cancer screening. The LOUISA-3D innovation consists of a novel optoacoustic imaging method that allows one to see under the skin through the tissues with high spatial resolution by listening to the sound of light absorbed in the body which can be used for detection and diagnostics of cancer and vascular diseases. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall innovation project Tomowave will finalize its engineering of LOUISA-3D before scaling up for clinical trials and system industrialization.

Keywords: optoacoustic imaging,breast cancer,non invasive,imaging,tomography,screening
Human “mini-liver” stem cell culture systems: from mechanisms behind liver cancer origin and recurrence to new therapeutic treatments (mini-liver SCCS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-20
End date: 2018-04-19
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the human population. But at present, there are no good in vitro models for HCC. Thus, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive HCC pathogenesis and there are only limited therapeutic options. In this project, our aim is to establish and characterize physiologically relevant 3D-liver cancer stem cell models and use them to increase our understanding of the mechanisms behind liver cancer with the final goal to develop anti-cancer strategies.

Keywords: liver cancer,stem cell,3d organoid culture,crispr,cas9
The Development of Students' Identities as Knowledge Builders (SIKB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 177319.8
EU funding (EUR): 177319.8
Participants: 2
Project status: CLOSED

This fellowship addresses the vital societal and educational challenge of preparing school students to successfully take part in the new knowledge society. The research component will examine students’ identities as knowledge builders as they study human body systems and climate change within fifth-grade classrooms designed as knowledge building communities. The objectives of the research address both theory and practice, aiming to (a) elucidate a conceptual framework on how boys' and girls' identities as knowledge builders grow over time; and (b) impact school implementation by articulating research-based design principles that enhance the development of students’ identities as knowledge builders. By introducing the notion of identity to knowledge building, I will bring together humanistic psychology and the learning sciences, leading to interdisciplinary advancements and practical knowledge about how to design sustainable learning communities using collaborative learning technologies. The outgoing and incoming phases of this fellowship entail close mentoring with two outstanding researchers, both of whom are directors of prestigious national research centres, to serve as supervisors. Together with formal training activities, the engagement of the supervisors in educational innovation created through research-practice partnerships will provide me with an ideal environment for my research goals to actualize. Aided by six short visits during the course of the fellowship with leading international scholars on knowledge building communities, I will create a consortium for European researcher-practice partnerships focused on implementing knowledge building communities, making a vital contribution to the 'Innovation Union'. Altogether, this fellowship will develop my career as an international leader in learning community research and design aiming to address a key societal and educational challenge of the innovation age.

Keywords: knowledge building,identity,collaborative learning and technologies,research practice partnerships
EEN Anatolia supports to increase the innovation management capacities of SMEs EENinnoSMEs3. (EENinnoSMES3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Türkiye,Türkiye,Türkiye,Türkiye
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 91121.0
EU funding (EUR): 91121.0
Participants: 6
Project status: CLOSED

The proposed project addresses the action for “Establishing services “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network” to improve the innovation management capacity of SMEs. In the period covering the years 2015-2021, Tier 1 and Tier 2 services were offered to SMEs by EEN Anatolia Consortium. (The contents of Tier 1 and Tier 2 were respectively generic promotion, networking services given by EEN staff and specialized advisory services given by innovation advisers). The activities foreseen under this proposal is to give Tier 3 services to SMEs. 53 full enhancing SMEs’ innovation management capacity service packages and 10 Key Account Management service packages will be offered to SME’s till the end of 2019 and every service package is foreseen.

Keywords: innovation management,key account management,improve assesment,benchmarking
Changing elites: how social and institutional change has altered the processes of elite formation over time? (CHANGINGELITES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-07-31
Duration (months): 65.0
Total project cost (EUR): 1497884.0
EU funding (EUR): 1459462.75
Participants: 2
Project status: SIGNED

Elites reveal the nature of inequality, allowing us to see the underlying structure of society. But, elites can also be the engines of inequality, driving forward changes ensuring the accumulation of power. So, when the people occupying elite positions change it says something about how the production of inequalities may have changed too. Most would agree (despite the paucity of data) that elites are different today than they were; but, what is contested is whether such changes signal a radical restructuring of the processes of elite formation. Two questions remain unresolved: 1) how has the composition of elites changed over time? and 2) did the major social, political, and economic upheavals of the last 200 years reconfigure elites through altering processes of elite formation? It has been difficult to answer these questions because of limited longitudinal data on elites. CHANGINGELITES will address these questions by creating a catalogue of the elite that is without equal in its empirical and temporal scope. This data set will combine information on education (schools and universities), club membership, parental wealth, economic capital, and family structure for around 120,000 people born since 1800. Alongside this data, we will also conduct 100 interviews with elites born in different periods, illuminating the varied trajectories that underpin this huge historical database. CHANGINGELITES will both shed light on the social composition of elites over time and seek to explain the changes and continuities within elites by exploring how institutional and policy shifts constrain and enable processes of elite reproduction. This ambitious, interdisciplinary study will radically alter our understanding of elite reproduction but, more than this, it will speak to a contradiction seen in many countries recently between the opening up of elite institutions and the massive accumulation of wealth, and in so doing will seek new ways to understand how inequalities are produced.

Keywords: elites,gender,education,institutions,policy
Warmed Icelandic Soils, Lipids and Sequencing: towards a better understood climate proxy (WISLAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-11-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

The distribution of the soil bacterial membrane lipids “branched glycerol dialkyl glycerol tetraethers” (brGDGTs) in geological records has been used to reconstruct palaeoclimatic conditions, specifically the mean annual air temperature and soil pH. However, the large error associated with the most recent brGDGT-based calibration, makes this method unsuitable for determining absolute temperatures. The fellow aims to perform geochemical and microbiological work that will result in the improvement of this palaeotemperature proxy. Firstly, an improved analytical method will be used, targeting not only fifteen brGDGTs that are currently used for palaeoclimate reconstructions, but including an additional fifteen brGDGT lipids, and a suite of precursors, whose diversity in soils is unstudied. This extended dataset will be measured in a well-studied, naturally (geothermally) warmed soil, linking the observed lipid distributions directly to the measured in-situ soil temperature (covering a 0-35°C gradient). Furthermore, the applicability of the novel temperature proxy proposed, will be tested in a well-studied dataset of European soils, covering a latitudinal temperature gradient. Although environmental studies point towards the Acidobacteria as the source organism, only one brGDGT has been found in an Acidobacterial culture so far and brGDGTs are still considered to be “orphan lipids”. Using a novel approach to identify the source organism, the fellow proposes to study the microbial community using a next-generation sequencing method. Tracking the patterns in (Acido)bacterial distribution along a temperature gradient, will enable the fellow to ascertain if the changes in the brGDGT pool are caused by a shift in the microbial community, or are caused by phenotypic plasticity. This interdisciplinary project will improve the accuracy and interpretation of lipid-based palaeoclimate reconstructions and will extend the applicant’s scientific experience and career perspectives.

Keywords: lipid biomarkers,climate proxy developement
Interactive Soil Quality Assessment in Europe and China for Agricultural Productivity and Environmental Resilience (iSQAPER)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Estonia,Italy,Switzerland,Greece,Hungary,Slovenia,China,Switzerland,Belgium,Poland,Romania,France,Netherlands,Netherlands,Netherlands,Portugal,Portugal,United Kingdom
Call: Soil quality and function (H2020-SFS-2014-2, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 6876625.0
EU funding (EUR): 5375375.0
Participants: 25
Project status: CLOSED

Knowledge regarding the complex interplay between agricultural land use and management and soil quality and function is fragmented and incomplete, in particular with regard to underlying principles and regulating mechanisms. The main aim of iSQAPER is to develop an interactive soil quality assessment tool (SQAPP) for agricultural land users that integrates newly derived process understanding and accounts for the impact of agricultural land use and management on soil properties and functions, and related ecosystem services. For this purpose, >30 long-term experimental field trials in the EU and China will be analysed to derive regulating principles for integration in SQAPP. SQAPP will be developed using a multi-actor approach aiming at facilitating social innovation and providing options to land users for cost-effective agricultural management activities to enhance soil quality and crop productivity. SQAPP will be tested extensively in 14 dedicated Case Study Sites in the EU and China covering a wide spectrum of farming systems and pedo-climatic zones, and rolled-out across the continents thereafter. Within the Case Study sites a range of alternative agricultural practices will be selected, implemented and evaluated with regard to effects on improving soil quality and crop productivity. Proven practices will be evaluated for their potential applicability at EU and China levels, and to assess the related soil environmental footprint under current and future agricultural trends and various agricultural policy scenarios. How the soil quality tool can be utilized for different policy purposes, e.g. in cross compliance and agro-environmental measures, will also be investigated and demonstrated. A comprehensive dissemination and communication strategy, including a web-based information portal, will ensure that project results are available to a variety of stakeholders at the right time and in appropriate formats to enhance soil quality and productivity in the EU and China.

Keywords: soil quality assessment,farming systems,agricultural management practices,soil properties and functions,ecosystem services,crop productivity,soil environmental footprint,multi actor approach
Live Tapings of Material Formation: Unravelling formation mechanisms in materials chemistry through Multimodal X-ray total scattering studies (MatMech)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-07-31
Duration (months): 78.0
Total project cost (EUR): 1493269.0
EU funding (EUR): 1493269.0
Participants: 1
Project status: SIGNED

With this proposal, I want to develop a new, multimodal approach to in situ X-ray scattering studies to unravel formation mechanisms of the solid state. The aim of the project is to develop a unified view of metal oxide nucleation processes on the atomic scale: From precursor complexes over pre-nucelation clusters to the final crystalline particle. The development of new materials relies on our understanding of the relation between material structure, properties and synthesis. While the intense focus on ‘materials by design’ have made it possible to predict the properties of many materials given an atomic arrangement, actually knowing how to synthesize it is a completely different story. Material synthesis methods are to a large degree developed by extensive parameter studies based on trial-and-error experiments. Specifically, our knowledge of particle nucleation is lacking, as even non-classical views on nucleation such as the concept of pre-nucleation clusters do not apply an atomistic view of the formation process. Here, I want to use new methods in X-ray total scattering and Pair Distribution Function analysis to follow nucleation processes to establish the framework needed for predictive material synthesis. One of the large challenges in studying nucleation is the lack of a characterization method that can give structural information on materials without long-range order. I have demonstrated that time-resolved X-ray total scattering gives new possibilities for following structural changes in a synthesis, and the use of total scattering has opened for a new view on material formation. However, the complexity of the structures involved in nucleation processes is too large to obtain sufficient information from X-ray total scattering alone. Here, I will combine X-ray total scattering data with complementary techniques using a new multimodal approach for complex modelling analysis, providing a unifying view on material nucleation.

Keywords: x ray scattering,in situ,nucleation