Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engineering Extracellular Matrices for Controlling Structure and Dynamics of Lipid Bilayer Membranes (EXTREME)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Türkiye
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 145355.52
EU funding (EUR): 145355.52
Participants: 1
Project status: CLOSED

Cell membrane is the most critical element that is common to all biological systems. This five-nanometer-thick highly flexible lipid bilayer is known to govern numerous vital cellular processes including endocytosis, exocytosis, enzyme activity, ion transport, cell-cell communication and cell division. Understanding and controlling multiscale structure and dynamics of the cell membrane is, hence, the key to regulate these crucial activities. So far, proposed approaches to tuning membrane dynamics, leading to its fluidity and stiffness, are based exclusively on modification of the bilayer composition that is highly cell specific. In this project, the researcher will use his previous research experience in harmony with expertise of the supervisor to uncover a novel and mechanistic way for regulating the dynamics of the lipid bilayers via engineering complex extracellular microenvironment. Beside its highly interdisciplinary and fundamental nature, this research has a significant potential to open up a new practical pathway to cure membrane-associated diseases, including but not limited to type-2 diabetes, cancer and Alzheimer. This research action will be a great opportunity for the researcher to acquire new scientific expertise, grow his worldwide collaboration network, practice key project management skills and effectively disseminate research outcomes - all of which are essential for being a successful independent academic.

Keywords: lipid bilayer,cell membrane,extracellular matrix,polymer,composites,viscoelasticity,membrane fluidity,biomaterials,hydrogels,crosslinking,neutron scattering,light scatte
Intelligent maintenance Decision Support System for the industry (mainDSS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Greece,Portugal
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

mainDSS represents a disruptive innovative IT solution supporting industries to improve the performance of their maintenance dept., irrespectively of the industrial sector and the plant size. The key idea lies on the fact that maintenance consultants always extract data from the corporate CMMS in order to assess maintenance data, apply performance indicators, and offer recommendations and audit reports for the management; a process that is obviously time-consuming, error-prone and costly! Capitalizing on this state-of-practice, mainDSS offers a unique IT system that, using a plug-in approach, dynamically ‘bridges’ with CMMS repositories and builds, piece-by-piece, the current ‘picture’ of the company's maintenance performance. This ‘picture’ constitutes the grounds on which mainDSS builds its expected outcomes, namely: maintenance ontology incorporating assessment criteria and KPIs for dynamic auditing, benchmarking for comparatively assess the performance of the industry, time-wise or in relation to other comparable companies, and effective recommendations (DSS) for improvements. Within this proposal, our main goal is to conduct a feasibility assessment and produce a business plan in order to enhance the current pre-commercial product with additional features and intelligence, and develop a solid product marketing in EU and globally. Highlights: * Assess viability of planned technical activities for product improvement. * Develop comprehensive market analysis (EU, global) and market plan, setting up sales network, campaigns and collaborations. * Study IP issues and decide on patents to be filed. * Assess economic viability of the venture (projections, market barriers, regulations and other constraints). mainDSS will have a significant impact to the EU industrial market, as it provides added value to all companies having a maintenance department, looking to improve the management of their assets, increase assets’ availability and control life-cycle costs.

Keywords: innovation,asset management,maintenance,decision support,benchmarking,auditing of performance,standards,en15341,pas55,iso55000
OvAge: an innovative, user-friendly digital methodology that quantifies ovarian reserve by integrating clinical, biochemical and 3D-sonographic data to help decision-making in all phases of woman life (Ovage)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Italy
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

OvAge s.r.l. is the owner of a pioneering patented medical device-software able in quantifying women ovarian reserve (both in term of fertility potential and distance to menopause) by integrating clinical, biochemical and 3D-ultrasonographic data. For the first time in this field of medicine, this instrument, also called OvAge®, gives as a result explicitly the ovarian age of a woman, a ready-to-use information that is going to revolutionize the relationship of women with themselves and with the Specialists in the field of Gynaecology. OvAge s.r.l. objective is to diffuse its innovative research product all over the world, with the purpose of helping both women (healthy or affected by infertility, benign or malignant pathologies) and physicians (general and specialists) in the management of many frequent conditions affecting the reproductive life of a woman. In this way, OvAge® aims to contribute the sustainability of health care systems, by reducing both costs related to late diagnosis of infertility and those related to useless surgeries in women affected by benign pathologies for which menopause is the best and cheaper therapy. Moreover, OvAge® will solve women needs for life planning by predicting reproductive potential and for safely solving common pathologies by predicting distance to menopause. To reach these goals, a feasibility study is needed. It will produce a market study for each European member state,proposals on best practice to enhance customer loyalty, a risk assessment of the plan and a potential licensing in order to launch OvAge® software medical device in the EU market initially through a web site. Later, OvAge s.r.l. aim to commercialize its product in the rest of the world (phase 2) as a medical hardware device. The most relevant market segment for OvAge® is the population of women residents in all EU countries, although our challenges and markets are global, since infertility and female pathologies are the same in all parts of the world.

Keywords: fertility potential,women health,ovarian reserve,distance to menopause
Modelling 2D Transition Metal Dichalcogenide Heterostructures (MODHET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-03
End date: 2019-03-02
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Although TMDs have been studied for decades, studies have been mostly limited to bulk materials. The properties of TMDs in atomically thin 2D forms can be significantly different from those in the bulk, such as the size of the band gap, the nature of the band gap (direct versus indirect), the existence of tightly-bound charged excitons. The physics of heterostructures formed by stacking different kinds of TMD layers are even more versatile and unexpected. While recent studies have experimentally demonstrated the possibility of synthesizing such novel 2D materials, the present project aims to study these new types of materials from a theoretical standpoint. We will perform state-of-the-art first-principles simulations using the most advanced exchange-correlation functionals developed in the host group for the accurate description of dynamical and charge transfer process within the time dependent density functional theory (TDDFT) as well as many-body perturbation approaches using the GW self-energy and including excitonic effects at the level of the Bethe Salpeter equation. We will also develop and implement new multi-scale algorithms in the codes needed to handle some of the tasks detailed in the project. This European Fellowship project will be hosted by a leading expert in the field, Prof. Angel Rubio of the University of the Basque Country (Spain). The project will also involve collaboration with top international experiment groups. The theoretical results acquired in this project will be used to guide and compare to experimental results with the goal of developing novel devices for future advances in nanoelectronics, photoelectronics and plasmonics. The progress of this project in exploring and understanding new physics of 2D TMDs and developing novel devices will have profound impacts on condensed matter physics, material science, as well as nano- and bio-science in the next decade.

Keywords: transition metal dichalcogenides,heterostructure,first principle calculations,time dependent density functional theory,many body perturbation theory,nanoplasmonics,photoelectronics
Synthesis of Novel Phosphor Sensor Particles for Advanced Flame Diagnostics (PHOSPHOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-07-31
Duration (months): 30.0
Total project cost (EUR): 199828.2
EU funding (EUR): 199828.2
Participants: 2
Project status: CLOSED

A longstanding problem in combustion research is that there is no means to simultaneously measure the temperature and velocity in high-temperature, chemically-reacting flows, which is essential to probe complex turbulence-chemistry interactions found in advanced combustion systems. The aim of this project is to solve this problem using a novel laser-based temperature-velocity imaging technique developed by the host organisation (Lehrstuhl für Technische Thermodynamik (LTT), Otto-von-Guericke Universität Magdeburg, Germany), which uses thermographic phosphor particles as a flow ‘tracer’. The primary objective of the action is to increase the measureable temperature range via synthesis of new phosphor particles optimised for flow temperature sensing. LTT will collaborate with the Advanced Combustion and Propulsion Lab (ACP), Princeton University, USA, who have developed innovative synthesis methods capable of producing phosphor particles with specific physical and optical properties. At ACP, the candidate fellow (LTT) will learn how to produce phosphors using these advanced methods, and then return to LTT where the new materials will be characterised and proven in flames. A laboratory for phosphor particle production and luminescence characterisation will be installed at LTT. The candidate fellow will develop unique, interdisciplinary expertise in thermographic phosphors, materials that will be at the forefront of future remote sensing technologies. The project will result in completely new measurement capabilities for fundamental and applied research, allowing the design of cleaner, fuel-efficient engines in key automotive, aerospace and power generation industries, thereby using fewer resources and reducing environmental impact. These novel materials will find use in lighting and display technologies and biological sensing, maximising both the impact of the action and opportunities for future collaboration with ACP and other EU research institutions and industry.

Keywords: temperature imaging,thermometry,thermographic phosphors,laser diagnostics,flow diagnostics,combustion,turbulence,particle image velocimetry,spectroscopic techniques,luminescent materials
Inhibiting tumor cell plasticity by targeting the epigenome in breast cancer (EPICAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Breast cancer is a heterogeneous disease which is classified into different histological and molecular subgroups presenting different clinical outcomes. Also, the diversity of genetic/epigenetic alterations in cancer cells and their interactions with the microenvironment enhance cell plasticity and result in intra-tumor heterogeneity. While tumor heterogeneity is a major hurdle to anti-cancer therapy, its underlying molecular mechanisms remain ill-defined. The Phosphoinositide 3-kinase (PI3K) pathway, which is hyperactive in more than 70% of breast cancers mostly due to oncogenic activating mutations (PIK3CA-E545K & PIK3CA-H1047R), is a major driver of cell transformation. Using spatio-temporal conditional expression of the mutant PIK3CAH1047R combined with in situ lineage tracing in transgenic mice, recent studies demonstrated that the PIK3CA-H1047R oncogene reprograms lineage-committed mammary epithelial progenitors into a multipotent state, giving rise to heterogeneous mammary tumors. However, the mechanisms by which the PIK3CA-H1047R oncogene reactivates multipotency in breast cancer remain unknown. An increasing number of studies demonstrates that epigenetic regulators participate downstream of PI3K/AKT kinases to regulate the epigenome and contribute to tumor malignancy. Given the importance of epigenetic regulation for cell fate, I hypothesize that the effects of PIK3CA-H1047R signaling on tumor cell plasticity are mediated by epigenetic regulators. Because single inhibition of the PI3K pathway often results in resistance, it is of paramount interest to identify new targets whose inhibition can synergize with PI3K inhibitors to block tumor outgrowth, reduce tumor heterogeneity and prevent resistance. The overarching goal of this proposal is to identify epigenetic regulators downstream of oncogenic activation of the PI3K pathway leading to tumor cell plasticity, and to validate them as new targets in breast cancer.

Keywords: breast cancer,plasticity,tumor heterogeneity,epigenome,dedifferentiation,epigenetic reprogramming,cell fate
Thermophone - a novel heat transfer based approach to global TOnal Noise cancellation in aviation (ThermoTON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-04-01
End date: 2026-03-31
Duration (months): 72.0
Total project cost (EUR): 1993265.0
EU funding (EUR): 1993265.0
Participants: 1
Project status: SIGNED

Limiting the number of people affected by significant aircraft noise is one of the most important tasks of modern civil aviation. Among different contributors, tonal noise is the most important due to regulatory definitions and its attenuation characteristics, with the largest contributor being the fan aero-acoustics. Current passive noise reduction methods alone are insufficient to conform with the increasingly stringent noise emission regulations. This motivates our research in active noise cancellation, based on creation of equal amplitude and frequency pressure waves, in opposite phase to the disturbance. Having identified that the actuator technology is the main hindrance against hardware implementation in flying platforms, we have been investigating a revolutionary technology based on a truly static and surface-deposited sound emitter (thermophone), which creates pressure fields by thermo-acoustic effects rather than the vibro-acoustics utilized by common speakers. Comprising of a periodically Joule heated electrically conductive thin layer, a highly efficient thermophone requires modeling of non-Fourier heat conduction in deposits. The project is divided into 4 multi-disciplinary objectives: 1. Derivation of accurate macro-scale heat conduction model, including non-Fourier effects 2. Developing thermophone performance model by analyzing thermo-acoustic effect 3. Optimization of performance by material and geometric selection, and by manufacturing processes 4. Demonstrating aero-acoustic fan noise cancelation via the thermo-acoustic effect created by static heat flux transducer In addition to the significance that this project will have to the field of aviation, I strongly believe that successful completion of each work package will provide dramatic improvements over the state of the arts in conduction heat transfer modelling, consumer electronics such as speakers, manufacturing methods for thermo-acoustic devices, and active aero-acoustic noise cancellation.

Keywords: non fourier heat transfer modelling,electro thermo acoustic conversion,thermophone optimization,advanced manufacturing techniques,speaker technologies,active noise cancellation,aviation noise
Research and Engagement for the European Reform University Alliance (ReERUA)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Germany,Bulgaria,Greece,France,Denmark
Call: Support for the Research and Innovation Dimension of European Universities (Part II) (H2020-IBA-SwafS-Support-2-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 1999461.25
EU funding (EUR): 1999461.25
Participants: 5
Project status: SIGNED

Re:ERUA is an ambitious project developing the trajectory of the European Reform University Alliance (ERUA). In this project, we will set up an Engagement Strategy for the fields of research and innovation and build our capacity for its implementation within our Alliance We intend to eventually unite all of our domain-specific strategies within this framework, including innovative teaching and learning. The “engagement angle” is our general method to tackle the definition of ERUA’s research strategy and our way to ensure the global coherence of our strategic outlook. As reform universities, a key motivation to map our trajectory towards engagement is its potential to sharpen our critical edge, which is a core mission for each of ERUA’s members. Collaboration with non-academic stakeholders is a crucial source of renewal and creativity for us and a means to assess existing processes and priority areas of development, test new ideas and ensure that we are indeed contributing continuously to the advancement and prosperity of society. To achieve the goal of establishing an Engagement Strategy for ERUA, we will identify thematic and methodological convergences between the members of the alliance. Secondly, in keeping with ERUAs experimental approach, we will interrogate innovation through the lens of engaged research and analyse the dynamics of co-creation processes at various interfaces. Thirdly, this analysis will be put into practice to foster human capital for Europe. Fourthly, we will develop our Open Science toolbox as a crucial enabler for our Engagement Strategy. Implementing this approach in an experiment-driven methodology, we will launch pilots and study cases to gather evidence about pathways to impact (internal and external) and models that might foster our institutional trajectory. The impact of these pilots and test cases will be assessed and will be the main criterion for evaluation and dissemination.

Keywords: engagement,research strategy,citizen science,open science,human capital inclusion,creativity
FUTURES 2021: Stories of Change (FUTURES 2021)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-05-01
End date: 2021-12-31
Duration (months): 8.0
Total project cost (EUR): 297587.25
EU funding (EUR): 297586.25
Participants: 4
Project status: CLOSED

FUTURES2021: Stories of change is an ambitious and dynamic programme of face-to-face and digital events designed to deliver the EU Commission's objectives. A consortium of five universities from across the South West UK have teamed up with world-class venues to deliver the largest celebration of contemporary research in the region, aiming to reach a minimum of 1.5 million people. We will reach out to citizens of the large cities of Bristol, Bath, Exeter and Plymouth, rural areas of Wiltshire, Somerset, Dorset, Devon and Cornwall, and will also transcend geographical boundaries through innovative digital and radio engagement. Using the best of both worlds we will create a truly inclusive and memorable festival of discovery tailored to diverse audience needs. A programme of 28 engaging events will enable over 300 researchers and MSC Fellows to interact with audiences and discuss the impact of contemporary research on people?s daily lives. Underpinned by principles of inspiration, inclusivity, accessibility, fun, learning, and discovery the events will demystify research and innovation, showing their value for individuals and societies locally and globally. Vibrant EU Corners at flagship venues and online will celebrate the contribution of EU funding and researchers to the region and wider. With a strong emphasis on engaging school children and families we will increase awareness of research careers and break stereotypes about researchers. Activities are also tailored to engage disadvantaged groups and rural communities who may not normally have access to researchers. Sound management by experienced partners, who have a track record of successful multi-partner projects, with a carefully constructed budget, clarity of roles, significant in-kind contribution from all partners, and an independently conducted evaluation using a mixed methods approach, will ensure that the project is successful in reaching its objectives and good value for money.