Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Characterizing properties of the interstellar medium to better understand how stars form in galaxies (eGALISM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-03-21
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The complex interplay between the interstellar medium (ISM) and the stars that it gives birth to is central to studies of galaxy evolution. The properties of the ISM, and especially its capacity to cool, determine when and where star formation occurs. Those properties are well-known in the Milky Way but not in external galaxies. Only recently has the extragalactic community dedicated effort to obtain very rich archives of the ISM tracers (dust, CO and now [CII]) from both space and ground based observatories, but we currently lack a detailed multi-wavelength and multiphase modeling that can exploit the data in a self-consistent way. The goal of this proposal is to characterize the ISM properties, physical conditions and structure, in nearby spiral and dwarf galaxies. For this, I will exploit the spectral and spatial information of those state-of-the-art observations, in particular from the Herschel, Spitzer and SOFIA telescopes, and build multiphase radiative transfer models to interpret the data and disentangle the main ISM phases present in those galaxies. I will analyze the effects of physical scales and of environment such as metallicity, SFR, AGN activity on the derived ISM properties in order to calibrate [CII] and CO as precise diagnostics of star formation. One of the main objectives is to better understand the physics and origin of the emission of [CII] in galaxies, as it is becoming a workhorse diagnostic in galaxies of the distant universe. This innovative project will be carried out at CEA (France) where it will be integrated in the existing expertise on the dust, Local Group and distant galaxies, and numerical simulations. This complementarity is essential to achieve the ambitious goals of this project and provides a unique opportunity for knowledge growth.

Keywords: galaxies,star formation,interstellar medium,ir mm observations,radiative transfer
Online DEposition over OceaNs: Modeling the effect of air pollution on ocean bio-geochemistry in an Earth System Model (ODEON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Iron (Fe) deposition from dust and combustion aerosols is essential for the marine primary productivity in large portions of the world ocean, where phytoplankton growth mitigates part of the anthropogenic CO2 emissions. Under polluted conditions, the atmospheric acidity and organic ligands dramatically enhance aerosol Fe-mobilization, perturbing also the marine CO2 uptake capacity upon aerosol Fe deposition. Air-quality regulations, designed to decrease future atmospheric pollution, will consequently moderate the dissolved Fe deposition flux over oceans and change its pattern. However, the effect of air pollution on the bioavailable Fe supply into the oceans and their primary productivity remains largely ambiguous, with a likely but poorly known climatic impact. The ODEON project will address this long-standing research question by performing for the first time coupled atmosphere-ocean-climate simulations with the European Earth System Model (ESM) EC-Earth, focused on the impacts of Fe deposition on the oceanic carbon-cycle. Recently, important advances were made by the applicant in understanding aerosol Fe dissolution and emission processes. However, ESMs still use simplified parameterizations and asynchronous coupling of Fe supply to the marine biogeochemistry, inserting severe uncertainties in the response of the carbon-cycle to anthropogenic emissions. ODEON aims to improve this situation by developing modelling tools beyond-state-of-the-art, to simulate the atmospheric Fe-cycle in EC-Earth coupled to the embedded ocean biogeochemistry model. The future fellow’s strong atmospheric chemistry modelling background, together with the advanced training-through-research plan on cutting-edge and multi-disciplinary EMS techniques, ensures the feasibility of this project. ODEON’s training scheme in climate modelling, ocean biogeochemistry and interaction with science-users will contribute to the applicant’s development as an independent and interdisciplinary researcher.

Keywords: iron chemistry,air pollution,ocean fertilization,earth system model,ec earth
A novel robotic parcel locker platform for cheap, efficient & convenient last-mile delivery (TARDIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The last mile in parcel delivery can take 35-50% of the total transportation costs because of the difficulty of transporting individual shipments to many different urban destinations. To meet growing consumer demand in e-commerce, parcel carriers undertake more delivery trips, congesting the roads & clogging the streets. While delivery vans were only 7% of urban travel in EU in 2015, they already accounted for 18% of the congestion. Efficient parcel delivery requires vans to deliver most packages to very few addresses. This is only possible with a dense network of urban mini-hubs that would serve many citizens at the same time. Logistics carriers have started deploying their own networks of click-and-collect parcel lockers but they are based on the outdated inefficient technology of a mailbox of a fixed size with an electric lock, which puts a limit on their scalability. Tardis is a compact, modular single-access window parcel locker that automatically defragments itself. Tardis rearranges parcels inside to free space for additional ones, which results in 300% more parcels stored than in a traditional parcel locker of the similar floor size. Tardis also contains several temperature zones enabling grocery & other perishable goods delivery. Tardis storage efficiency will allow us to build & deploy smaller & more efficient parcel locker networks in dense city areas capable of handling all typical online purchases of an urban dweller. With our parcel lockers, we will be able to reduce the costs of the carriers 3-4x, offering them a competitive advantage, create an open scalable urban delivery network & lay the foundation for same day delivery—the next frontier in online retail & B2C logistics. We forecast revenues of €41m by 2023 (for a multi-city network of ~539 units), aiming for €350m+ by 2027. In this project we will finalize the value proposition, create maps of locations for 1st installations, carry out cost/benefit analysis & secure partnership agreements.

Keywords: parcel delivery,last mile delivery,robotics
FAult Tolerant MOLecular Spin processor (FATMOLS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Spain,Spain,Italy,Italy,Spain,Switzerland,United Kingdom,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-03-01
End date: 2023-08-31
Duration (months): 42.0
Total project cost (EUR): 3207081.25
EU funding (EUR): 3207081.25
Participants: 13
Project status: SIGNED

FATMOLS introduces a new paradigm in the world of quantum technologies: the molecular spin quantum processor. Artificial magnetic molecules that realize spin qudits, with multiple addressable quantum spin states, are controlled, read-out and linked via their coherent coupling to on-chip superconducting circuits. This novel scheme integrates quantum functionalities at three different scales (nuclear spins, electronic spins and circuits), is inherently modular and therefore scalable, and is also very flexible. It admits different qudit realizations, can create diverse qubit arrays and topologies and perform quantum simulations and fault-tolerant quantum computing, with quantum error correction either embedded in each molecule or distributed among different nodes in a topological lattice. FATMOLS objective is to provide a proof-of-concept of one of the repetition unit cells of this platform, involving at least two molecules with multiple and fully addressable levels, from which more complex architectures can be created. To achieve this goal, FATMOLS will design suitable algorithms and architectures for specific applications (quantum chemistry simulations, quantum error correction) and create, test and interconnect the different components of this technology (molecules, superconducting nano-resonators and control electronics), through a creative collaboration between disciplines and between top-level academic and industrial partners. In the short term, the project will reshape multi-frequency magnetic resonance instrumentation, a key enabling technology of widespread use. In the medium to long term, it will define an alternative roadmap to reach the next level of computational power (100-1000 qubits) and, therefore, address quantum optimization and quantum simulation problems with direct impact on diverse economic sectors, including agriculture, health-care, energy and artificial intelligence.

Keywords: molecular spin qudits,superconducting resonators,microwave technologies,spin coherence and read out,circuit qed,hybrid quantum architectures,quantum algorithms,quantum error correction
EdTech and the birth of platform education: An ethnographic account of a start-up in the age of global education (MORPHOGENESIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

In its latest action plan on digital education, the European Union underlined the ambition of ensuring that all citizens are prepared to live and work in the digital age. However, the current COVID-19 pandemic, with its widespread closure of schools and universities, has thrown into sharp relief how the introduction of digital technology fundamentally reshapes the organisation of education. Within a few months, it became evident that schooling without school or studying without campus prompts the influx of new, private actors on an unprecedented scale. This project focuses on such digital reorganisation of education, cut off from the classroom. In particular, I propose to investigate how the conversion towards digital learning platforms participates in a worldwide disruption of pedagogical valuation processes. While existing research has so far favoured questions of power and inequalities, the disruptive capacity of these learning platforms to radically redefine what education values as worth learning has hardly been studied. To fill this gap, MORPHOGENESIS proposes (1) to build a framework that formulates an ensemble of concepts with theoretical insights from three related (sub)disciplines (sociology of education, organisation studies and the study of regionalisation and globalisation processes). With the help of Luhmannian systems theory, the coherent formulation of such framework will make it possible to analyse how, through such digital platforms, the reorganisation and the differentiation of global education go hand in hand; (2) to develop an extended case ethnography of the start-up scene in New York, where this so-called EdTech is currently being imagined, coded and executed into the platforms that explicitly aspire to disrupt contemporary education. Together, the conceptual framework and methodology will enable a better grasp of the metamorphosis that education is currently undergoing and the unprecedented role that online learning platforms play within it.

Keywords: globalisation of education,education industry,privatisation,educational technology,systems theory,sociology of valuation
Chytridiomycosis resistance through sexual selection (CRISIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Sexual selection (SS) is a strong evolutionary force that can promote or inhibit adaptation to environmental challenges. When populations face novel pathogens, SS can influence their persistence by impacting the spread of resistance alleles. The major histocompatibility complex (MHC) encodes proteins that recognize pathogens. Many vertebrates preferentially mate with partners carrying beneficial MHC alleles, conferring higher resistance to the offspring. Here, I propose to study the role of SS in the evolutionary dynamics of amphibian resistance to chytridiomycosis (pathogen Bd), an emerging infectious disease that is causing population declines and extinctions worldwide; with poison frogs, a species-rich group in which the strength of SS differs between species. i) I will test whether mate choice is influenced by MHC and infection status of both partners. ii) I will use theoretical models to predict under which circumstances SS can accelerate the evolution of disease resistance. iii) I will use population ecology to evaluate the association between the strength of SS and species’ susceptibility to Bd in natural populations. This project will provide fundamental scientific knowledge on the relationship between SS and the evolution of immunity by exploring the interaction between Bd and amphibian MHC. It builds on the recent insight that natural selection drives MHC evolution in amphibians, and originally explores the role of SS in this process in a uniquely integrated experimental, theoretical and field ecological fashion. I have worked with Bd throughout my academic career; this project allows me to focus on the hosts, which has been the target of fewer studies and is in dire need of conservation. The project will be conducted at the University of Groningen under the supervision of Dr. Maan, an expert on sexual selection and poison frogs; and Dr. Pen, a an expert in bioinformatics and modelling. Field work will be carried out in Brazilian Amazonian basin.

Keywords: evolution,chytridiomycosis,amphibians,batrachochytrium dendrobatidis,dendroibatidae,poison frogs
Super resolution imaging of nanoPMOs for cancer drug delivery (MANTARGET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-04
End date: 2023-01-03
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

In recent years, nanomaterial-based various drug delivery carriers have been developed for the potential targeted cancer therapy. However, still the advanced study for optimization of size, shape, surface chemistry of the nanocarrier and observation of biological interaction and evaluation of such nanocarrier are not well-developed that limit their use for the efficient clinical applications. Therefore, superior understandings of the cellular interaction of the nanocarrier with different physicochemical properties are essential and challenging for improved the cancer treatments. In this project, we will focus on the optimization of different physicochemical properties of nanocarrier such as size, shape, surface chemistry and etc via investigation of its biological interaction and evaluation by a potent imaging technique. For this purpose, we will synthesize a library of efficient biodegradable drug delivery carrier periodic mesoporous organosilica nanoparticles (nanoPMOs) with controlled size and shape and then functionalized with different targeting ligands with the controlled number per nanoparticle for mannose-6-phosphate receptor over-expressed prostate cancer. Then we will study the nanoPMOs-prostate cancer cell interactions, internalization pathway and intracellular degradation of nanoPMOs through the stochastic optical reconstruction microscopy (STORM). We will further evaluate the drug delivery efficacy of nanoPMOs and toxicity mechanism of drug loaded nanoPMOs to support microscopic observation. Thus the result of this biological interaction and evaluation of nanoPMOs with different physicochemical properties via super-resolution microscope STORM will help to develop a novel drug delivery carrier for prostate cancer therapy with optimal properties for clinical applications.

Keywords: organosilica nanoparticles,storm,drug delivery,targeting,prostate cancer
Watergate: Development of a low-cost solar desalination technology (Watergate)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: France
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Watergate project aims to bring to the market by 2017 the most competitive desalination solution for middle scale applications, a market niche accounting for 900 Million € of annual investment in 2014. Its major value-added lies in the unique combination of a total independence on fossil fuel, the solution requiring only solar energy, and very competitive water costs ranging between 0.80€ and 2€/m3 for applications above 100m3/day. The major innovation of Watergate lies in the fact that the whole system “desalination-energy source” has been redesigned, resulting in an integrated system that solves the critical issue of the low efficiency of renewable energy desalination. The value-added of Watergate relies on two pillars: - The reduction of the size of the required solar field by more than 20% through a minimization of the energy consumption and a maximization of the energy efficiency; - The absorption of the variations in energy intensity, making it possible to work without any complementary energy source. The market potential for Watergate is substantial. It will not only target the current low to middle scale market accounting for 500,000 m3/day of yearly installed capacity, it will also boost the development of desalination in energy importing countries: Spain, Malta, Cyprus, Greece and Israel; as well as extend the scope of the market to users with no access to fossil fuel. Under Phase 1 of the SME Instrument, the feasibility study will first focus on the definition of the business positioning of Cyrga. The resulting identification of the targeted segments and the relevant business model will make it possible to develop a corresponding marketing strategy and adapt the financial plan, providing the missing parts for the elaboration of a strategic business plan by September 2015. The objective for phase 2 would be to develop a real-life demonstrator, based on a prototype currently under development, which should be achieved by the second half of 2015.

Keywords: desalination,water energy nexus,renewable energy,low carbon economy
Mapping the retrotransposon-mediated layer of neuronal gene regulation in the human genome (PRIMATE-TE-IMPACT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-08-01
End date: 2023-01-31
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Throughout evolution, the human genome has been attacked by retrotransposons, parasitic DNA elements that spread through our genome by a copy-paste activity. I previously showed that SVA elements, the youngest class of retrotransposons in our genome, harbour a strong gene-regulatory potential which is normally repressed by KRAB zinc finger protein ZNF91 (Jacobs et al., 2014, Nature). However, for reasons unknown, repression of retrotransposons is much less efficient in the human brain, resulting in activation of the enhancer potential of SVA elements spread throughout the human genome. The importance of these SVA insertions for the evolution of human neuronal gene-regulatory networks, and how many genes have come to depend on SVA's regulatory influence, remains elusive. In this research program, I will use ‘cortical organoids’; three-dimensional brain tissues derived from human and primate stem cells, to investigate how recent SVA insertions have impacted human neuronal gene expression. Furthermore, I will investigate how changes of the epigenetic landscape in neurons affect the activity of retrotransposons in our genome and the influence they have on nearby neuronal genes. Finally, I will explore the possibility that loss of epigenetic silencing of retrotransposons is responsible for dysregulation of genes associated with neurological diseases. Preliminary findings suggest a potential role for retrotransposons in susceptibility loci for Alzheimer's and Parkinson's disease. Finding further support for this in the current research program, will form the basis of a novel concept which explains how changes in the epigenetic landscape can uncover a dormant genetic predisposition to disease.

Keywords: retrotransposons