Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigation into the Molecular Mechanisms Underlying NEmatode recognition by the Ma resistance protein in perennial plum roots (IMMUNE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-15
End date: 2021-11-14
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Plant-parasitic nematodes are major root pathogens that affect drastically plant development and growth. Predominant species, such as the root-knot nematodes (RKNs) Meloidogyne spp., represent a global threat for annual and perennial crops causing huge crop losses worldwide. In Europe, RKNs were mainly controlled by toxic pesticides that are getting banned. One of the most promising alternative to pesticides is to rely on biological control and on the plant innate immunity for disease resistance in crops. The plant immune system is a multi-layered network that enables the detection of pathogens using different classes of receptors. The presence/absence of such receptor can determine whether or not the plant will be resistant/susceptible to a particular disease. At INRA Sophia Agrobiotech Institute (ISA), an immune receptor gene Ma, from the toll/interleukin-1 receptor, nucleotide-binding and leucine-rich repeat (TIR-NB-LRR or TNL) family, has been cloned from the plum tree Prunus cerasifera where it provides a broad resistance against numerous RKN species. A unique feature of Ma resides in five repeated exons encoding a large C-terminal extention. Interestingly, each of those exons carries a recently characterized post-LRR (PL) domain which is found in a single copy in many other TNLs from different plant species. The PL domain’s function remains unknown but its conservation suggests an important role in TNLs. The peculiar architecture of Ma provides a great opportunity to decipher the involvement of the PL domain in TNL–mediated immunity. Combining complementary approaches, the proposed IMMUNE project aims to describe how Ma triggers immunity in response to RKNs in plant roots and how the PL domain participates in the recognition and signalling. This project, undertaken by Dr Simon Saucet at ISA, will provide new insights into the molecular mechanisms of plant immunity and contribute to the development of methods to control RKNs infection in crops.

Keywords: plant immunity,root knot nematodes,tnl resistance receptor,defence signalling
RESEARCHERS FOR HUMANITY (R4H1415)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Romania
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-10-31
Duration (months): 18.0
Total project cost (EUR): 144000.0
EU funding (EUR): 124000.0
Participants: 4
Project status: CLOSED

“Researchers for Humanity 2014-2015” will invite important players from science and education to join forces in creating the most important national wide project that is inviting the public to come, play, talk and learn about researchers and to understand how science can be used in the benefit of humanity. All the previous actions that we did as beneficiary from 2007 has created an outstanding awareness of the European dimension of the event, so that now the Researchers Night is seen as one of the most important communication event for research and education institutions. Now is the time for creating the premises for a national platform, in which every researcher or teacher or student that wants to create an event for promoting researchers in their area to be able to join and get involved, being aligned with the national strategy. The project will have a series of events, in which Researchers’ Night will be the main promotion and communication tool for all the activities that will be done throughout the year. The event itself will be organized by us in 1 important location of 12 major, medium and small cities from all over Romania. Also, through the platform, we will invite associated events to get enrolled and be supported by us through promotion at the national level. We aim to reach 40000 visitors, over 150 researchers, students and teachers and over 500000 prs to be exposed to the awareness campaign. The logo will assemble with the old one in order to create a link with previous years and awareness of the European and national dimension of the event. For celebrating in 2015, a partnership with one of the most important TV stations in Romania is done, so that during the event of 2014 recordings to be made that will be published all over the year until the 2015 event. Also, testimonials from all organizers from 2007 until now will be invited together with some of their public to present the impact that the event had in their community.

Keywords: interactive education,national platform,scene,tv insert,hands on,scifun
Neotithic transition in the Iberian Peninsula: reviewing an old question from new technological and computational genome wide approaches (NeoGenHeritage)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The research goal of this proposal revolves around a widely debated topic in archaeology, anthropology and population genetics: the dynamics of the spread of farming into Europe, or Neolithic transition. For a long time, this key event that was to define modern Europeans has fuelled a dichotomic research debate. In short, did the Neolithic spread into Europe as the result of cultural or demographic diffusion? While many approaches can be attempted, in the last few years, ancient DNA (aDNA) studies have strongly contributed to shedding light on this topic, through the recovery and analysis of an increasing number of mitochondrial and nuclear genomes from prehistorical human samples. Far from closing the debate, these palaeogenomes are revealing a more complicated scenario, where the times, paths and genetic legacy of the Neolithic diffusion seem to have been different in different geographic areas. Furthermore, as the genomic data increase, the aDNA field is soon facing the challenge of evolving from a research area largely based on technical development for the recovery of short DNA fragments, to the analysis of larger datasets (ultimately, whole genome data) in the context of human population genetics. I therefore propose an interdisciplinary project aimed to increase our knowledge on the Neolithic transition by generating, for the first time, genome data from ancient human remains from the Iberian Peninsula at the times of the Neolithic transition. Having been the last region of Europe reached by the Neolithic diffusion, the IP is a crucial area for understanding the relative role of migration and cultural changes. By combining modern technologies for the recovery of ancient genomes, with state-of-the-art statistical data analyses in the context of human population genetics, this project will contribute to the development of practical and theoretical approaches to make the most of aDNA as a powerful research tool in the fields of archaeology and antropology.

Keywords: ancient dna,neolithic,next generation sequencing,capture,approximate bayesian computation,bioinformatics,bioarchaeology,human population genetics,palaeogenomics
Critical Infrastructure Protection using Adaptive MILS (CITADEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Spain,Italy,Sweden,France,France,Czechia,Netherlands,United Kingdom,United Kingdom
Call: The role of ICT in Critical Infrastructure Protection (H2020-DS-2015-1, 2015)
Start date: 2016-06-01
End date: 2019-10-31
Duration (months): 41.0
Total project cost (EUR): 6065267.25
EU funding (EUR): 4842819.47
Participants: 17
Project status: CLOSED

Critical infrastructures (CI) rely on complex safety- and security-critical ICT systems placed into unpredictable environments and forced to cope with unexpected events and threats while exhibiting safe adaptive behavior. Recent security trends stress continuous adaptation to increase attacker work factor and to confound reverse-engineering. Critical CI systems must undergo extensive and costly scrutiny under diverse certification regimes. Improved, effective and affordable development and certification methods are essential. CITADEL will provide innovative platform technology, methodology and tools for development, deployment, and certification of adaptive MILS systems for CI, to be demonstrated in three industrial CI use cases. The solution enables robust and resilient CI through monitoring and adaptive self-healing mechanisms that respond to natural and malicious occurrences by intelligently reconfiguring hosts, functions, and networks, while maintaining essential functions and defences. CITADEL is based on MILS, an approach featuring modular construction and compositional assurance, reducing the time and cost for development, certification, and maintenance of dependable systems. The MILS platform, based on a separation kernel, manages physical resources while establishing and enforcing a verified application architecture. Leveraging advances from the D-MILS and EURO-MILS projects, CITADEL will extend the MILS approach by adding dynamic reconfiguration to the MILS platform, and Monitoring and Adaptation Systems enabling resilience to adversity while preserving vital system properties. CITADEL supports certification of Adaptive MILS systems by analyzing configuration change mechanisms, adaptation system, configuration properties, and configuration change policies with automated verification tools, and by providing an innovative runtime evidence management agent to automatically generate up-to-date certification assurance artifacts as the system adapts.

Keywords: resilient critical infrastructures,mils,adaptive self healing,compositional assurance,dynamic reconfiguration,verification tools,automated certification assurance
Bootstrapping Inflationary Cosmology (InflaBoot)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-09-30
Duration (months): 36.0
Total project cost (EUR): 240530.4
EU funding (EUR): 240530.4
Participants: 2
Project status: CLOSED

Cosmic inflation is one of the most promising explanations for the origin of the structure in the observed universe. However, while quantum-mechanical fluctuations during an early epoch of inflationary expansion provides a remarkably good description of the data, establishing the precise field content during inflation is a fundamental challenge for primordial cosmology. Since it is almost certain that the inflationary era involved physics beyond the Standard Model, this is also an incredible opportunity to learn about physics at the highest energy scales from current and future cosmological observations. On the theoretical side, it is important to classify the signatures of new degrees of freedom in primordial correlation functions to compare with observations. However, progress has been hindered due to the lack of tools to go beyond the simplest of cases. I propose a research and training programme to develop new systematic tools at the interface between scattering methods in de Sitter (dS) space, and, via holography, the conformal bootstrap in the dual CFT picture, to carve out the non-Gaussianities associated to: (1) Regge trajectories of higher-spin fields predicted by string theory/other UV complete theories of gravity (2) partially massless higher-spin fields, both at tree and 1-loop level. This proposal combines my expertise on higher-spin theories, scattering methods on anti-dS and holography with extensive training on various aspects of inflation and CMB physics from world-leading experts at IAS Princeton. The project will be completed at ULB, whose complementary expertise on higher-spins and holography will provide fertile ground to transfer my knowledge gained from the outgoing phase and continue the directions generated by the project. The importance of the project outcomes to cosmology and high-energy physics, as well as the experience gained, will facilitate me in obtaining a junior researcher position in Europe – the natural next step in my career.

Keywords: a ds,conformal field theory,cosmic inflation,string theory
Clinical biomarker for arterial hypertension based on micro-vascular retinal imaging (RetinArt)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: France
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The RetinArt project addresses a major public health issue: cardiovascular (CV) events, which are the leading cause of death in the world. The overall project objective is to validate the arteriolar wall-to-lumen ratio (AWLR), a clinical biomarker of the alterations caused by arterial hypertension (AHT) in small arteries. The clinical validation is expected to prove that assessments of the AWLR enable earlier detection of damage caused by AHT, better prediction of CV risk, and more effective adaptation of AHT therapy to patient. To measure the AWLR biomarker, Imagine Eyes has developed a new retinal imaging system that uses the eye as a window to the microcirculatory system. This instrumentation provides unparalleled microscopic resolution thanks to a breakthrough adaptive optics technology derived from astrophysics. It enables clinicians, for the first time, to directly visualize the microscopic walls of retinal arterioles and quantify the AWLR using automated segmentation software. The examination procedure is totally non invasive and its reliability has been successfully tested with AHT patients in a hospital environment. The phase 1 of the RetinArt project is a feasibility study that aims at establishing the methodological and economic validity of the proposed clinical validation, and at planning its future execution. The main deliverables expected from phase 1 are a validation plan and a detailed business plan. These outcomes are essential milestones in the translation of Imagine Eyes technology to a new standard that will help reduce the risk of serious complications in wide numbers of AHT patients.

Keywords: microvascular imaging,retinal imaging,adaptive optics,hypertension
Innovative Technologies for Inspecting Carbodies and for Development of Running Gear (Gearbodies)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Italy,Germany,Spain,Spain,Italy,Germany,Lithuania,Greece,Belgium,France,France,United Kingdom,United Kingdom
Call: Innovative technologies for Carbodies and Running Gear of the future (TD1.3 + TD 1.4) (H2020-S2RJU-OC-2020, 2020)
Start date: 2020-12-01
End date: 2023-06-30
Duration (months): 31.0
Total project cost (EUR): 2419968.75
EU funding (EUR): 2419968.75
Participants: 14
Project status: SIGNED

The success of the European rail system to foster the modal shift towards rail requires cost-efficient and reliable long-lasting trains. GEARBODIES contributes to this effort by improving the efficiency of rolling stock maintenance in close collaboration with the ongoing CFM-IP1-01-2019 (PIVOT2). To achieve the above, GEARBODIES follows a twofold approach: extending overhaul periods and improving maintenance processes. The extension of overhaul periods will be facilitated by developing high-performance and long-lifetime components for running gear. The improvement of maintenance processes will be boosted by developing innovative NDT technologies to optimise inspection processes for lightweight carbody shells. GEARBODIES will design and prototype several elastomer-metal running gear components, suitable for serial production, based on high-performance new elastomer formulations and existing elastomers not yet applied in rolling stock elements. In addition, the project will also explore innovative technologies for the development of low LCC bearings. New lubrication solutions, new materials for races and rollers, novel polymers for cages and the effects of new bearing geometries will be researched, among which the most feasible ones will be integrated in a new bearing design and prototyped. GEARBODIES will develop an innovative modular platform to reduce the inspection time of lightweight carbody shells. The platform will incorporate tailored thermography and ultrasonic inspection systems and will facilitate the automated detection and assessment of defects throughout the thickness of the shell by using a customed software module. GEARBODIES will benefit form a strong multidisciplinary consortium, made of 13 partners from 8 countries, committed to the mentioned actions towards maximisation of the project's impact.

Keywords: running gear,carbody inspection,maintenance,elastomer,bearing
Low-Cost Metasurface Leaky-Wave Antenna for Mobile Satellite Communications (MELASAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Canada
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-03
End date: 2018-08-22
Duration (months): 24.0
Total project cost (EUR): 163872.0
EU funding (EUR): 163872.0
Participants: 2
Project status: CLOSED

With the increasing demand of broadband connectivity, satellite communications are receiving significant attention, since the requirement for infrastructure in Earth is minimum. However, broadband low-latency satellite connectivity entails several challenges from the point of view of radiofrequency engineering: antennas with high gain, beam steering capabilities and broad bandwidth are required. Current solutions are either parabolic dishes with mechanical steering, which are bulky and require maintenance, or phased- arrays with electronic steering, which are low-profile but significantly expensive. Therefore, a reconfigurable low-cost high-gain antenna with no moving parts and small size is an important market niche and can revolutionize satellite communications. In this way, the current limitations of connectivity to mobile users, such as in maritime or aviation, or in isolated or poor areas, where expensive infrastructure cannot be deployed, can be overcome. The project proposes a novel low-profile and low-cost solution for broadband satellite communications based on the fusion of two fields: metamaterials and leaky-wave antennas. By combining such an inexpensive antenna with a metasurface, the antenna characteristics can be enhanced to meet the challenging requirements of satellite services at a very low cost and size. The researcher will have the opportunity to learn this cutting-edge technology from the pioneer group in this kind of solutions at University of Toronto,and import this knowledge into Europe to contribute to developing the satellite communication industry and open new markets. Moreover, the knowledge of the group at the University of Malaga (including the researcher) about both broadband leaky-wave antennas and active components will be crucial to develop such a broadband solution, which must implement electronic reconfigurability.

Keywords: antenna,metamaterials,metasurface,radiofrequency,applied electromagnetics,microwave engineering,leaky wave antenna
OvaRenew as a first-line therapy in impaired egg quality treatment (OvaRenew)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Slovenia
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Potenza Medica Ltd. is specialised in the development and commercialisation of innovative fertility products. Our solution is tackling one of the deepest human needs-reproduction. With OvaRenew as a first-line therapy in ovarian infertility, we intend to grab business opportunity to be the first in the world with disruptive fertility solution for women with impaired egg quality. Global fertility services market was in 2015 estimated to be between 27-36 billion € with growth rates of 8-9% in EU and 4% in US. The novelty is in innovative combining of new findings in fertility and nutritive science, which will revolutionize current industry practice. OvaRenew is based on disruptive findings of stem cells in ovaries that are able to transform into oocytes under defined conditions. Those will be initiated through the substances, administered orally. So far, there is no effective and practical strategy available for impaired egg quality. They all are highly invasive with significant health complications, expensive, not focusing in helping woman to produce genetically own child. OvaRenew will enable women with impaired egg quality to produce their own child while drastically decreasing cost and invasiveness of the procedures on one and country health and other expenditures on the other hand. In 2 years (Phase2), OvaRenew can be prepared for global commercialisation. With 1 mio € investment, final product is planned to be introduced on global markets, with focus on developed world. In Phase 1, a feasibility study will be performed with focus on risk assesment and IP protection. While we are operating in one of the most regulated industries, in close dialogue with regulators, we will assure alignement for safety and regulatory requirements such as those pertaining to cell procurement, GMP, ethics and clinical trials. Suitable contract manufacturer will be contracted. Comprehensive business plan will be elaborated to facilitate initial market up-take and worldwide expansion

Keywords: ovarian infertility,egg quality,first line therapy,stem cells,global markets