Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ModeRN Approach to ocular disease treatment - Smart lipid-based nanoparticle systems for the delivery of mRNA to the ocular tissues (LIPOmRNA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 3
Project status: CLOSED

Many severe ocular diseases lead to visual impairment and blindness in millions of patients worldwide, and the number is rapidly growing in aging populations. Most ocular diseases are still without drug treatment and the current treatments are based on the use of small molecules and protein drugs. However, poor ocular absorption and rapid elimination restrict their development and use in ophthalmology. Technology for mRNA transfer into the cornea and retina and subsequent expression of encoded proteins may open widely applicable possibilities for the treatment of ocular diseases (e.g. various retinal degenerations, uveitis) as topical eye drops or intravitreal injections. However, clinical application of mRNAs is limited by their poor in vivo stability and low cellular entry. Therefore, efficient and safe delivery systems for ocular mRNA transfer are urgently needed. Our research program aims to develop lipid-based nanoparticle (LNP) systems that are specifically tailored for mRNA delivery into the corneal, conjunctival and retinal cells. The project will address the critical anatomical and physiological barriers of ocular mRNA delivery topically and intravitreally. Chemical structure and composition of LNPs will be carefully modified to optimize mRNA delivery across ocular barriers. Smart pH-sensitive LNPs with eye specific surface moieties will be used to target ocular cells and trigger mRNA release and cytosolic delivery. Moreover, eye drop formulations will be mucoadhesive, increasing precorneal residence time, whereas intravitreal injectables will be capable of permeating in the vitreous and inner limiting membrane into the retinal cells. The representative in vitro and ex vivo test models will be used to select the most promising LNPs for versatile animal experiments. Finally, in vivo pharmacokinetics and mRNA mediated anti-VEGF responses of the delivery systems will be investigated to understand their translational potential towards clinical use.

Keywords: smart lipid based nanoparticles,delivery system design and creation,ocular mrna delivery,ocular barriers,topical and intravitreal administration,ocular pharmacokinetics,anti neovascular effect
Mental Navigation Gone Awry: Testing the Mental Navigation Framework in the Context of Rumination (MenNaRum)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Estonia
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2026-01-05
End date: 2028-07-04
Duration (months): 30.0
Total project cost (EUR): 257181.9
EU funding (EUR): 257181.9
Participants: 2
Project status: SIGNED

MenNaRum aims to test the mental navigation framework (Aru et al., 2023) in the context of rumination. The theory proposes that the spatial navigation related activation in the hippocampus is indicative of a universal navigation mechanism that underlies spatial and non-spatial navigation, i.e. navigation between concepts or thoughts. The navigation process is goal directed and can lead to sudden solutions - insights. When ruminating, people think about their personal problems repetitively, often referred to as "being stuck in a loop", potentially indicative of the underlying navigational phenomenon. Rumination has been characterized by dwelling on negative autobiographical memories associated with hippocampal activation. So far, the link between rumination and navigational processing has not been established. MenNaRum aims to (1) establish a link between rumination and spatial navigation by applying a data-driven network analysis approach in an online study, (2) experimentally test the effects of insight induction on rumination, and navigation within a novel virtual-reality task, and (3) systematically review human and animal literature to uncover potential common rudimentary mechanisms for rumination and spatial navigation. In this project, I will integrate experimental psychopathology, behavioral neuroscience, and information technology approaches. MenNaRum will generate new hypotheses, and potentially shift rumination research paradigms towards integration, and interdisciplinarity. Implications include (1) a better understanding of the basic mechanisms of rumination, (2) novel VR-based measurement tools, some of which I will test in the project, and (3) inspiration for new interventions which can relieve the socioeconomic burden of affective disorders. MenNaRum will provide me with the important transferrable, virtual-reality, translational analysis and reviewing skills which will enhance my future interdisciplinary research on rumination and related processes.

Keywords: rumination,spatial navigation,insight,gaussian graphical models,depression
Bio-Butadiene: Renewable Innovation Driving Green Economies (BIOBRIDGE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

ETB Global B.V. (ETB) is transforming the environmental footprint of everyday rubber and plastic products by developing sustainable, bio-based processes. Leveraging over 100 years of combined experience in petrochemicals and catalysis, ETB's first target is Bio-based Butadiene (Bio-BD), a crucial building block for products like car tires, toys, and medical gloves, using bio-ethanol as a feedstock. Traditional butadiene production is highly carbon-intensive, contributing over 70 million tons of CO2 emissions annually. ETB’s innovative catalyst technology provides a defossilized alternative, reducing reliance on fossil fuels and supporting global decarbonization efforts. With manufacturers like Arlanxeo, BASF, and Trinseo committed to bio-material targets by 2030, and global brands such as LEGO and Goodyear establishing green material goals, ETB is well-positioned to meet the rising demand for sustainable materials. We plan to build a demo plant by 2025 for technology de-risking and begin licensing by 2026, with the goal of constructing a commercial-scale plant by 2030. We are applying for EIC Accelerator funding to scale our technology from the demo plant to a 50 kilo-tons per annum commercial facility, achieving TRL 8. This funding will help validate our technology and attract further investment, enabling us to bridge the gap from demo to full-scale production, paving the way for a 100 kilo-tons per annum commercial plant and accelerating the defossilization of the chemical industry.

Keywords: bio based materials first of a kind commercial plant
From Bees as a Service (BaaS) to Software as a Service (SaaS) to enhance biodiversity and reduce pollution (BeeOimpact)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-06-30
Duration (months): 28.0
Total project cost (EUR): 2494584.28
EU funding (EUR): 1746209.0
Participants: 1
Project status: CLOSED

BeeOimpact platform (incl. BeeOmonitoring and BeeOgarden mobile app) is a unique SaaS solution using the bee ecosystem to extract valuable biodiversity data and metrics. Bees forage 4 bn flowers on a circular surface of 80 to 700ha /solitary bee nest/colony. They gather pollen from these flowers and bring them back in the bee nest or beehive. We collect pollen samples daily via a device placed outside the hive or in the bee nest. As pollen samples capture air and part of soil pollutants and contain plants’ DNA, we will analyze this data (we already have 10yrs of aggregated data) to feed the AI platform. BeeOimpact will provide an assessment of a site, with just 1 click, without having to analyse the samples coming from each site, via AI, expert systems, data mining, machine Learning and deep Learning techs, the origin and assess the level of poorly monitored pollutants and plant diversity level/quality. Then targeted solutions to enhance biodiversity and lower pollution are provided

Keywords: predictive analyses,internet services and applications,data retrieval,database,iot,biodiversity,pesticides,pollution,data mining,expert systems,machine learning,artificial intelligence
OMI AI ECG Model - application for more accurate heart attack diagnosis (OMI AI ECG Model)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Slovakia
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2026-06-30
Duration (months): 30.0
Total project cost (EUR): 4495966.5
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Globally, 50M patients with chest pain present to emergency departments each year. In these patients a 12-lead electrocardiogram (ECG) serves as a swift and readily available diagnostic test for identifying acute obstructive heart attacks (OMI), a life-threatening condition that requires prompt transfer to a cardiac catheterization laboratory. The OMI AI ECG Model is an AI-powered mobile application that can process any ECG and diagnose OMI faster and more precisely than current state-of-the-art criteria, according to which 50% of OMI cases are missed or delayed in treatment. This technology combines a patented ECG digitization system converting any paper-form or screen-based images of ECGs into standardized digital waveforms and an AI algorithm trained by physician experts with 50+ years of experience in OMI diagnosis from ECG who established the OMI paradigm. It is immediately applicable, doesn't require additional hardware and works with any healthcare infrastructure. In a large international validation of over 2,000 patients it has proven to be twice as sensitive as the current standard of care in diagnosing OMI and can detect it 2.9 hours faster. Due to more accurate and faster diagnosis, this solution will cause a paradigm shift in heart attack patient management, saving millions of lives and decreasing the economic burden of cardiovascular disease.

Keywords: health,cardiac and cardiovascular systems,obstructive myocardial infarction,cardiovascular diseases,artificial intelligence,diagnostics,medical devices
EUROpean Laboratories for Accelerator Based Science (EURO-LABS)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,France,Switzerland,Slovenia,Poland,Germany,Belgium,Croatia,Spain,Romania,Portugal,Hungary,Finland,Sweden,Netherlands,Japan,United States,United Kingdom
Call: Research infrastructures services advancing frontier knowledge (HORIZON-INFRA-2021-SERV-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 14703604.06
EU funding (EUR): 14174110.0
Participants: 33
Project status: SIGNED

Nuclear and High Energy Physics explore at different scales what the universe is composed of and how it functions. Breakthroughs in accelerator and detector technologies combined with innovative experiments represent the key to new discoveries. High Energy Physics, while preparing for the HL-LHC, is pursuing the design of the next generation particle accelerators and detectors, balancing the present and the future. Newly available beams of nuclei far from stability and intense stable beams have opened new avenues, ranging from the production of new elements to the exploration of nuclear properties at extremes of temperature, angular momentum and isospin. It is of vital importance to simultaneously optimize the use of existing and new Research Infrastructures (RIs) to conduct curiosity-driven research addressing fundamental questions and technological challenges, and also advance projects with broad societal impact. This project provides efficient access to the available resources to a large fraction of EUROpean Laboratories for Accelerator Based Sciences (EURO-LABS). It allows the diverse community of users to choose the best state-of-the-art RI or a network of RIs to conduct high impact research, fostering knowledge sharing across scientific fields. The proposal brings together, for the first time, the three communities engaged in Nuclear Physics, Accelerator and Detector technology for High Energy Physics, pioneering a super community of sub-atomic researchers. It allows a synergic implementation of best practices for data management and activities relating to targeted service improvements at these RIs. Joint training activities are foreseen to develop the skills of the next generation researchers to optimally use the RIs services for scientific and technological discoveries. EURO-LABS will create synergies and collaborations between the RIs of the Nuclear and High Energy communities, enhancing Europe's potential for successfully facing future challenges.
Fundamental indeterminacy of spacetime (FIndS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

It has been a long-lasting major mystery in modern physics that our current best theories, namely general relativity for spacetime and quantum mechanics (QM) for matter, are incompatible with each other, revealing deep conceptual flaws in the way we understand the physical world. We currently lack a truly fundamental theory of nature that provides a quantum description of space and time (i.e. a theory of quantum gravity (QG)). Yet, an important obstacle currently stands in the way of the current development of QG. Indeed, influential research programmes attempting to find a theory of QG yield theories in which spacetime is emergent, rather than fundamental. Such approaches, called emergent spacetime theories (ESTs), raise critical philosophical challenges for the very possibility of considering these theories as describing the fundamental physical world, beyond their mere mathematical content. There exists a gap between the mathematical nature of the theories and their postulated meaning. Such a gap is highly detrimental to the development of fundamental physics. The project FIndS intends to fill that gap by providing a clear, intelligible interpretation of what it means for spacetime to be emergent in ESTs. The project’s outputs are expected to contribute to the following scientific impacts. First, the research will provide a unified solution to the current conceptual obstacles of ESTs. In the long term, this can foster new knowledge in philosophy (of spacetime, emergence and indeterminacy), and quantum physics, thereby contributing to the objectives of the European Quantum Flagship initiative. Second, the research will promote a specific realist interpretative recipe that can, during and shortly after the project, be used as a defence of scientific realism in the face of theory change and proliferation. The researcher has a background in physics and quantum metaphysics (esp. of spacetime). FIndS is the ideal project to complete her expertise in that field.

Keywords: philosophy of spacetime,emergence,indeterminacy,quantum physics,quantum gravity
Truth, Truthlikeness, and Trust: Shaping Reality in Ancient Near Eastern Societies (TANES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2029-08-31
Duration (months): 36.0
Total project cost (EUR): 396991.08
EU funding (EUR): 396991.08
Participants: 3
Project status: SIGNED

The TANES project, Truth, Truthlikeness, and Trust: Shaping Reality in Ancient Near Eastern Societies, investigates why formal truths were established and how misinformation was used in Old Babylonian (OB) documents (2003-1695 BCE). Through interdisciplinary approaches, it aims to redefine our understanding of truth construction in ancient societies, significantly impacting both Assyriology and broader studies of historical information dynamics. As Van McGhee notes, truth is essential for understanding group and individual behavior. In ancient societies, truth's socially constructed perception validated interpersonal bonds, with trustworthiness of information and its conveyors crucial for the stability of political, religious, and social groups. However, the authenticity of information often conflicted with its intended use. The project explores the concept of "truthlikeness," introduced by Karl Popper, which allows for varying degrees of informational manipulation. This focus shifts from traditional truth (factual reality) to a strategic use of truth and misinformation that served specific social and political purposes in Mesopotamian society. OB documents, especially from the royal archives of Mari, show how truth was shaped to influence decisions and maintain social order, often relying on trust in supernatural validations rather than factual accuracy. The project analyzes a carefully selected corpus of political correspondence and legal documents to uncover the deliberate manipulation of truth and the role of trust. This examination includes rhetorical strategies, performative speech, and the construction of socially accepted truths within OB political and legal contexts. TANES seeks to break new ground by applying contemporary theories of truthlikeness and information manipulation, offering fresh insights into ancient societies' information dynamics and contributing significantly to both Assyriology and broader historical research.

Keywords: assyriology
All Magneto-Electric Spin Logic Gates (ALLME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The surge in electronic equipment used daily across the globe, from end-user devices to data centres, has led to a craving for more energy-efficient computing devices. However, the current Moore’s Law epitomised miniaturisation process of CMOS transistors will be gradually limited by increasing power densities and associated chip heating. Therefore, much research has been devoted to the development of alternative computing devices. Spintronic devices, which exploit both the charge and the spin of electrons, are seen as a promising beyond-CMOS approach due to their ultralow energy per operation, non-volatility, and capability to build more expressive logic gates. Despite much recent success in realizing spintronic logic gates such as those that employ magnetic domain walls or spin waves as information carriers, there are two major limitations that impede the inclusion of such devices in microelectronic technologies. The first is the lack of energy-efficient transducers for interconversion of signals between the magnetic and electrical domains. The second issue is the inability to propagate magnetic information carriers over large distances in the magnetic domain, i.e., the lack of magnetic interconnect. To address these challenges, we propose a novel spin logic device concept (ALLME) based on layered strain-mediated magnetoelectric composites containing both piezoelectric and magnetostrictive materials. By exploiting its magnetoelectric effect, the magnetisation in a nanomagnet can be rotated with voltages, and in the inverse effect, the change in magnetisation will result in a voltage output. ALLME aims to deliver one of the most technologically competitive spin logic concepts, with an emphasis on ultra-low energy consumption and all charge-based interconnects that are readily to be cascaded in complex logic circuits, to solve the long-standing challenges in spin logic.

Keywords: nanomagnetic devices,magnetoelectric effects,spintronic logic devices,magnetoelectric composites,beyond cmos devices