Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantifying cell dynamics in myelopoiesis during immune responses (Dynamyelo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Although changes in immune blood cell number is commonly used as a sign of infection or inflammation in the clinics, the cell dynamics parameters controlling cell numbers during an immune response (division, differentiation, and death) are not well understood. As myeloid cells are short lived, changes in myeloid cell numbers comes from cell production by myelopoiesis. Given the importance of cell dynamics in immune response, we propose to unravel the cell dynamics of myelopoiesis during inflammation. However, few methods allow to measure in vivo the cell dynamics parameters. Methods to study division in vivo can trace up 10 divisions, apart for the telomere measures that have no maximum but is restricted to cell types without telomerase activity, unlike our cells of interest. As we estimate a minimum of 14 divisions from hematopoietic stem cells to myeloid cells, a new method to follow over 10 divisions is required. This proposal will overcome this methodological barrier by developing the DivCounter a new method, to count division in vivo in mice. Our innovation is: 1/ to implement a quantitative counter of division combining wet and dry lab. 2/ compatible with single cell transcriptomics to measure cell differentiation status with the required granularity. 3/ creating a new mouse model. Using the DivCounter, we will quantify for the first time the number of divisions in homeostatic myelopoiesis. We will also infer division, differentiation and death rate, uncovering the understudied role of death in myelopoiesis. We will also unravel how division and death change during emergency myelopoiesis and when and how myelopoiesis returns to homeostasis after inflammatory stimulations. This knowledge will shed light on which of the cell dynamics parameters to intervene to change myeloid cell numbers, opening therapeutic perspective for the design of vaccines and immunotherapies. The DivCounter will serve other fields in which cell dynamics is key (cancer, development).

Keywords: division,emergency myelopoiesis,mathematical model,cell dynamics
Understanding the Processes Underlying Societal Threats using Novel Cluster-based Methods (PROCESSHETEROGENEITY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1499500.0
EU funding (EUR): 1499500.0
Participants: 2
Project status: SIGNED

Social scientists are eager to answer questions about relations between constructs like beliefs or values. For example, do values affect climate change beliefs? Do perceived threats predict political beliefs? Do risk perception and susceptibility to misinformation determine vaccine hesitancy? Polarized beliefs about climate, politics, and vaccination are a societal threat and it is important to study what drives them. Large-scale survey data is gathered to do so. Using regression to answer the questions ignores that constructs are not directly observable, but measured by survey items containing measurement error (challenge 1). Not correcting for this causes the studied effects to be underestimated and conclusions to be misguided. When many groups are involved - such as many countries in the European Social Survey - the underlying processes likely differ across groups. For example, drivers of climate change beliefs may differ for countries experiencing extreme weather. Group-specific or multilevel analyses result in numerous group-specific regression slopes or random effects, making it hard to find which regression effects are different or similar for which groups (challenge 2). Across many groups, the constructs' measurement is often inequivalent or 'non-invariant', for example, due to translation (challenge 3). A measurement model indicates how items measure a construct and disregarding non-invariance in this model invalidates the comparison of effects among constructs (i.e., one may find differences that are actually due to non-invariance). By tackling challenges 1-3, the proposed mixture multigroup structural equation modelling framework provides the tools to break new ground in understanding what drives constructs like polarized beliefs. A clustering finds subsets of groups with common processes. Flexible measurement models account for non-invariance so that the clustering focuses on the processes. I will implement the methods in freely available software.

Keywords: structural equation modeling,factor analysis,regression analysis,measurement error,measurement invariance,mixture model,latent class analysis,surveys,questionnaires,cross national surveys,experience sampling,multiple group data,multigroup data,intensive longitudinal data
Toeplitz and related operators in large Bergman spaces (LARGE BERGMAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Finland,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: CLOSED

We consider operator theory in Bergman spaces consisting of analytic functions on complex domains. The aim is to extend known, central results of standard Bergman spaces to the case of large spaces, which are naturally defined by using rapidly decaying, non-doubling weights. The need of weighted estimates is as apparent as anywhere in harmonic analysis and applications. In the context of Bergman spaces, the case of non-doubling weights is still partially open due to the fact that such weights are not so naturally related with the hyperbolic metric of the underlying domain. In this context we plan to consider questions of boundedness of the Bergman projection in weighted L^p-norms in relation to the boundedness of Toeplitz and also little Hankel operators. In the case of standard weighted Bergman spaces there is a well-known connection of the theory to the deformation quantization. Another topic of recent interest is formed by the so called localized operator classes. We aim to extend these studies to the case of large Bergman spaces. The methodology comes from the earlier joint works of the researcher and a number of well known experts in the area, on the topic of pointwise estimates of the Bergman kernel among others, and from the techniques of the supervisor and W.Lusky, as well as Fock-space methods, which are naturally related to nondoubling measures.

Keywords: bergman space,non doubling weight,bergman kernel,toeplitz operator,little hankel operator,atomic decomposition,deformation quantization,boundedness,compactness
Sustainable materials and process for green printed electronics (Sustain-a-Print) (SaP) (Sustain-a-Print)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Denmark,Greece,Spain,United Kingdom,Germany,Sweden
Call: Functional electronics for green and circular economy (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 4135317.5
EU funding (EUR): 4135317.5
Participants: 13
Project status: SIGNED

Prompted by the dire forecasts for increased resource extraction and waste generation, and their detrimental effects on climate and biodiversity, a Circular Economy Action Plan has been put forth where electronics and electronic equipment have been identified as a priority product group with circularity potential. With an annual growth in waste of 2%, this group is one of the fastest growing waste streams in the EU, while less than 40% of electronic waste is recycled within the EU. There is a need to explore new options for electronics that are designed for reuse, repair, and high-quality recycling. To address this challenge, several factors must be considered such as the Industrial End User’s (IEU) specifications, Life Cycle Analysis (LCA) and the products end-of-life (EoL). Printed electronics (PE) is an additive manfucaturing method that can address these challenges and is characterized by its versatility, scalability, and low material usage, thus making it an ideal candidate for a circular production of electronics in general. Flexible and even stretchable electronics can be obtained with this method by printing conductive and dielectric inks on flexible/stretchable substrates opening new applications in the market. However, similar to traditional electronic production methods, current life cycle for a PE product starts with materials (substrate, conductive and dielectric materials) obtained through mining of raw materials. These materials are put into production lines, consisting of large volume analogue printing, gluing on discrete components and lamination processes. The EoL are either landfills or incineration, which in both cases, destroys precious materials, thus forcing the use of mined raw materials. The main goal of Sustain-a-Print (SaP) is to open new life-cycle routes and to design and implement sustainability into each step of the life-cycle. This includes choice of materials, their usage, their origin, their processing, assembly, and EoL.

Keywords: biosensors,membrane switch,nanomaterials,flexible electronics,lignin nanoparticles,pla substrates,conductive inks
MATIC: Materiality of Imperial Crossings during the age of steam (c. 1850-1950) (MATIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: CLOSED

The MATIC (Materiality of Imperial Crossings during the age of steam, c. 1850-1950) project aims to deepen our understanding of modern colonial empires by exploring the material culture of maritime crossings within the British and French colonial empires during the age of steam (c. 1850-1950). This project focuses on the personal belongings of steamship travelers to explore the trade of items relevant to journeys at sea, the lived experiences of imperial maritime crossings, the ‘colonial situations’ that arose on board ships, as well as the material circulations that empires facilitated. Bridging colonial history, material culture studies, and maritime history, MATIC will go beyond the state of the art by demonstrating that materiality was a crucial dimension of imperial ‘lives in transit’, whose study illuminates the social, cultural, and political ramifications of imperial mobility, and fosters new insights into the role of materiality in the imperial archive. This project further sheds new light on how actors largely absent from written sources – colonized passengers, women, and children – intimately experienced colonial empires. To accurately capture this global and intimate history, MATIC employs an innovative and interdisciplinary methodology, integrating quantitative methods as well as theoretical perspectives from material and visual culture studies, gender studies, oral history, new mobility studies, and sociology. In addition to printed sources, it draws on a variety of archival materials from numerous repositories in England and France, surviving artefacts from museum collections, and oral history interviews. This project will significantly enhance the ER’s professional experience by further diversifying his research methodologies, enhancing his ability to work in a international environment, and enabling him to build a long-lasting international network that includes researchers, curators, and archivists.

Keywords: colonial empires maritime history globalisation material culture studies steamships lives in transit 19th century 20th century
Spectrally Stable and High-Performance Perovskite Pure Blue Light-Emitting Diodes (Blue-PeroLED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

In this project, we aim to develop metal halide perovskites-based spectrally stable, high-performance pure blue light-emitting diodes (LEDs). This research objective is crucial for the development of perovskite-based solution-processed, cost-effective next-generation solid-state lighting and display technologies. Despite achieving perovskite green and red LEDs with EQEs > 25% and luminance (L) >100000 cd/m2, the sought-after perovskite pure blue LEDs (455 nm < peak emission < 470 nm) have been lagging far behind in their performance with max. EQEs < 8% and L < 1000 cd/m2, and typically suffer from severe spectral instability due to ion migration and phase segregation. These inefficient perovskite pure blue LEDs hold back the perovskites' integration into next-generation solid-state lighting/display technologies. Here, I will design spectrally stable and efficient mixed ‘Cl/Br’ halide quasi-2D perovskite (Q2DPe) pure blue emitters through “compositional engineering”, in particular by using chlorinated bulky organic cations (BOCs) and introducing a small fraction of large size A-site cations. The resultant Q2DPe will comprise of “Cl-rich surface with homogeneous halide distribution and localized lattice distortions within the unit cell", and are speculated to possess elevated ion migration activation energies, which will suppress ion migration and phase segregation, thereby ensuring spectral stability. Further, I will design and fabricate LEDs with interface engineering, and study LED test device structures (HTL-only and ETL-only devices) to find out suitable pairs of HTL-ETLs to achieve efficient and balanced charge carrier injection, eventually resulting in spectrally stable high-performance pure blue LEDs. The project outcomes will be spectrally stable, efficient Q2DPe pure blue emitters and high-performance pure blue LEDs with EQE > 15%, luminance > 50000 cd/m2, and lifetime > 500 h at 500 cd/m2, which largely exceeds the current state-of-the-art.

Keywords: mixed halide quasi 2d perovskites,spectrally stable pure blue emitters,compositional engineering,high plqys,led device engineering,suitable pair of etl htls,high performance pure blue leds
SeLf-powered self-rEshaping Autarkic skin For wireless motes - LEAF (LEAF)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Germany,France
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-03-01
End date: 2028-02-29
Duration (months): 36.0
Total project cost (EUR): 2565321.25
EU funding (EUR): 2565321.25
Participants: 4
Project status: SIGNED

We will combine 3D reshaping, energy harvesting, and energy storage within a single, thin foil. The thin foil of several micrometer thickness is going to be fabricated by inkjet and capillary printing on a temporal carrier support and consists of an adhesion sacrificial layer (own technology relying on lanthanum acrylic acid coordination polymer) and a strain inducing bilayer made of hydrogel and a stiffening layer (own innovation technology). The combination of specifically designed bilayer polymer system (polyethylene alt maleic anhydride type hydrogel and polyimide materials) is able to reshape into Swiss-roll architectures with few hundreds of micrometer diameter through a selective etching of the sacrificial layer and swelling of the hydrogel in a water-based solution. We will implement high precision capillary printing (HPCAP) to print dedicated structures with high control over length, thickness and separation with (sub-)micrometer resolution and high reproducibility of a variety of materials, which deliver different functionality. Self-powering of the autonomous device is ensured through the use of bi-functional materials deposited into interdigitated micro-electrode structures, function as light converter and storage materials at the same time. The thus created photo-storage microscale supercapacitor is embedded onto the thin foil and will serve as autonomous power source for the integrated silicon chip. The 2D area of the ultrathin foil delivers maximized surface area of the interdigitated finger structure and ensures sufficient light absorption to power the integrated RFIC (e.g. an active tag/sensory system). The optimized weight (R ~ 0.95) will be granted by the ultrathin nature of the foil (around 5um), while mechanical stability of the final device is ensured through 2D-to-3D reshaping. Key feature of our final device is the ability to retain its functionality also after 3D reshaping and its deployment onto the application surface.

Keywords: photo chargeable micro supercapacitors transparent conductive oxide nanoparticles 2d materials ultrathin substrates 2d 3d self reshaping substrates high precision capillary printing
Yeast-based solutions for sustainable Aviation Fuels (YAF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Belgium,France,Germany,United Kingdom,Estonia,Denmark,Finland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 2637583.2
EU funding (EUR): 2637583.2
Participants: 13
Project status: SIGNED

Sustainable aviation fuels (SAF) are the only short-term alternative to fossil fuels in aviation. Considering the increased number of passengers forecasted in the near future, a massive increased in SAF production has been estimated in the years to come. To fulfill this increase in demand, the combination of existing and new renewable production chains is needed. Current SAF-producing pathways are at different levels of maturity, implementation or even commercialization. However, lowering the cost and supply chain development are key challenges for commercial-scale SAF deployment. Using biowastes as feedstock for SAF is challenging but necessary to make SAF competitive with fossil fuels. In this context, yeasts may be key players to generate economically-viable SAF intermediates (terpenes or fatty acids (FA)) in an environmentally-friendly way from biowaste. This SAF production by biological means is very new and presents a lot of remaining challenges and training gaps that have to be addressed. YAF research programme aims at; i) producing carbon sources from biowastes, ii) developing new yeast cell factories to produce SAF, iii) designing new bifunctional catalysts, iv) achieving efficient strategies for FA/terpenes extraction, and v) creating robust framework tailored to the scaling-up methodologies and life-cycle sustainability assessment of different SAF producing routes, which will support decision-making. To achieve this, the right integration of biology, biotechnology, chemical engineering and environmental sciences will be required. Thus, the prime training/networking aim of YAF is to train the next generation of researchers in a highly interdisciplinary and intersectorial research environment such that they can soundly address upcoming challenges concerning production yeast-based SAF. YAF has been designed to strengthen European research and innovation, enhancing research visibility and generating a critical mass to address European (and global) challenges

Keywords: sustainable aviation fuels,yeast,biowaste derived carbon sources,terpenes,fatty acids,bifunctional catalysts
The development of a full scale plant for the production of sustainable medium chain fatty acids (CircularChain)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 3681502.5
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

To meet the value-chain-wide need for a viable circular economic model that facilitates the achievement of the EU’s sustainability goals, ChainCraft has developed an economically-viable process that converts organic residues into valuable biobased medium chain fatty acids (MCFA) for the agrifood and material industries. Our unique and patented solution is based on a three-step process using ‘open culture fermentation’ and downstream processing to create mixed MCFA and their downstream fractionated pure products. We take organic residues from municipalities, supermarkets and food production industries and convert them into MCFA. These MCFA are supplied to industries producing a.o. animal feed, food, herbicides, plasticizers, and detergents. In return, some of these companies supply industries of which their waste stream will again be used as feedstock in our process, making it truly circular. Our next target in making the chemical industry more sustainable, is the construction of a full scale plant using our circular technology. The first milestone in achieving this target is the final investment decision (FID). To reach this milestone we need the are several major steps with significant challenges we need to make: a contract for feedstock and location; validate our product with our potential customers; arrange agreements with these customers; and then design our plant based on this acquired knowledge. As these steps involve significant risk the support of EIC is key in achieving our target and will help us making the necessary steps to execute our sustainable plan.

Keywords: fatty acids waste sustainable mcfa circular