Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigate maternal and paternal risk factors for violence during pregnancy: lasting impact for everyone (IMPROVE_LIFE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Germany,Bangladesh
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1999924.0
EU funding (EUR): 1999924.0
Participants: 2
Project status: SIGNED

Globally, one in three women are estimated to experience physical and/or sexual intimate partner violence during their lifetime. Pregnancy is a life-changing time, when violence might subside, occur for the first time or intensify. Abuse and its consequences can be severe for both mother and children, and cascade into the next generation. IMPROVE_LIFE’s aim is to understand the risk and protective factors for violence during pregnancy, its short and long-term effects and intergenerational impact. This project proposes the first theorization and empirical assessment of violence during pregnancy, its intergenerational transmission, and health and social effects using clinically tested biomarkers. It will synthesize new and existing intergenerational cohort data from diverse settings: Bangladesh and the UK, use pooled multi-country survey datasets and qualitative evidence. IMPROVE_LIFE will address five objectives: 1) investigate the short- and long-term social and health effects of violence during pregnancy on women and their children, 2) explore if violence during pregnancy is a marker for severe violence, 3) study maternal and paternal risk factors for the transmission of violence to their children, 4) elicit male and female experiences and views of the causes of violence during pregnancy, and 5) provide evidence on the global applicability of established pathways explaining violence during pregnancy. The fundamental gains for the protection of women and prevention of violence emerging from this ambitious research programme are immense. The high risks arising from following a cohort after two decades, integrating clinically collected biomarkers and male voices are addressed by a dedicated and experienced PI and team and robust research approaches. The new empirically tested, ecological theoretical framework will be vital to inform policy, prevention and response programmes addressing violence during pregnancy, thereby improving lives.

Keywords: violence against women and girls,intimate partner violence
Prison Oversight: Improving Prisons in Europe (POIRE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2024-03-01
End date: 2025-10-31
Duration (months): 20.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

With 1.5 million people in prison across Europe, and a need to ensure human rights standards are upheld in places of detention, international oversight of prisons plays a fundamental role in upholding European values and ensuring decent and fair treatment. Oversight of prisons by international human rights bodies, such as the European Committee for the Prevention of Torture (CPT), is now a growing and global phenomenon. The PRILA project, from which this proposal derives, discovered that while oversight of prisons has value, it is undermined by inconsistent government engagement and by low awareness of human rights and oversight functions amongst prisoners. Prison Oversight: Improving Rights in Europe (POIRE) addresses these challenges. It is the first initiative to develop, test and evaluate a set of programmes that support and train governments in how they report to the CPT, a long standing and well-respected prison oversight body, and raise awareness of human rights and oversight in prisoner populations. POIRE will assess need, develop, design and deliver its programmes, and evaluate them for effectiveness in two case study countries subject to a visit from the CPT. Its findings will also feed into a public policy arm, which will make submissions for reform to the legal frameworks for prison oversight in Europe and globally, contributing to sustainable and embedded change. A key element of POIRE is to lay the foundations for a post-POIRE spin-off, not-for-profit enterprise to deliver its programmes to states, prison systems, oversight bodies and NGOS globally. POIRE seeks to strengthen international oversight in prison and states and prisoners' capacity to engage with human rights monitoring. In so doing, POIRE aims to improve human rights compliance in prisons and support prisoner engagement with rights, thereby upholding the European value of fundamental rights protection in places where they are vulnerable.
REshaping Supply CHAins for Positive social impact (ReSChape)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Italy,Portugal,Germany,Spain,Netherlands,United Kingdom
Call: Towards a new normal? Employment and social impacts of changing supply chains and declining trade intensities (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2260671.25
EU funding (EUR): 2260671.0
Participants: 10
Project status: SIGNED

The aims of this proposal are: • To analyse social, economic and environmental changes and disruptions (including covid) and evaluate their impact on SCs, identifying related challenges in terms of relationship between countries, configuration of the network, impact on employment. • To study and propose a set of SC models for the evolution of global SC integrating strategies like resource efficient, closed-loop and humanitarian as a way to increase EU resilience and sustainability. Particular attention will be given to the role of digitalization as a way to establish new paths for social inclusion taking into consideration the needs of urban and rural areas. Some important European sectors like fashion, automotive, medical and machine tools will be analysed with case studies and survey. • To develop Innovative tools for monitoring and assessing sectoral trade patterns and defining mechanisms to evaluate relationship of disruptions like pandemic and global value chains taking into consideration impact on employment, economic growth, incomes etc also in the long term. Moreover, it will be analysed the impact of different trade patterns, on the EU value added of sectoral and countries with a specific focus on analyzing income inequalities and proposition of decent work and social cohesion. Particular attention will be gives to gender issues and social disparities. • To develop innovative policy scenarios with recommendations for future global value chains: policy scenarios will be based on Key horizontal issues impacting on several sectors and will provide recommendations for EU, national and sectoral strategies, policy measures and targeted actions aimed at shaping fair, inclusive and sustainable trade patterns, value and supply chains as well as production networks.

Keywords: supply chain,new normal,circular economy,social indicators
FAME: OPEN-ENDED MANIPULATION TASK LEARNING WITH FAME (FUTURE-ORIENTED COGNITIVE1 ACTION MODELLING ENGINE) (FAME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2499063.0
EU funding (EUR): 2499063.0
Participants: 1
Project status: SIGNED

The realization of computational models for accomplishing everyday manipulation tasks for any object and any purpose would be a disruptive breakthrough in the creation of versatile, general-purpose robot agents; and it is a grand challenge for AI and robotics. Humans are able to accomplish tasks such as “cut up the fruit” for many types of fruit by generating a large variety of context-specific manipulation behaviors. They can typically accomplish the tasks on the first attempt despite uncertain physical conditions and novel objects. Acting so effectively requires comprehensive reasoning about the possible consequences of intended behavior before physically interacting with the real world. In the FAME project, I will investigate the research hypothesis that a knowledge representation and reasoning (KR&R) framework based on explictly-represented and machine-interpretable inner-world models can enable robots to contextualize underdetermined manipulation task requests on the first attempt. To this end, I will design, implement, and evaluate FAME (Future-oriented cognitive Action Modelling Engine), a hybrid symbolic/subsymbolic KR&R framework that will contextualize actions by reasoning symbolically in an abstract and generalized manner but also by reasoning with “one’s eyes and hands” through mental simulation and imagistic reasoning. Realizing FAME requires three breakthrough research results: (1) modelling and parameterization of manipulation motion patterns and understanding the resulting effects under uncertain conditions; (2) the ability to mentally simulate imagined and observed manipulation tasks to link them to the robot’s knowledge and experience; and (3) the on-demand acquisition of task-specific causal models for novel manipulation tasks through mental physics-based simulations. To assess the power and feasibility of FAME, I will use open manipulation task learning as a benchmark challenge.
Targeted Nano-formulations for Treatment of MRSA: A multicomponent platform for nano-formulated treatment of resistant microbial infections (LeadtoTreat)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway,Poland,Germany
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-03-01
End date: 2026-02-28
Duration (months): 48.0
Total project cost (EUR): 2665565.0
EU funding (EUR): 2665564.75
Participants: 3
Project status: SIGNED

Many bacteria that cause infectious diseases develop resistance to not only the primary antibiotic treatments available in the clinic but also to drugs of last resort which often require long treatment periods and come with significant side effects. At the same time many promising lead compounds with high activity and wide therapeutic windows have failed to progress to clinical trials due to poor solubility, protein absorption or other difficulties in formulation (e.g. low drugability). LeadtoTreat proposes a new solution to these challenges by introduction of a platform for future infection treatment enabling targeted delivery of novel lead compounds with low drugability as well as synergistic combinations of antibiotics and potentiators in a nano-formulation. A novel dual targeting approach, with both direct targeting toward the pathogenic bacteria as well as to areas of inflammation will be employed. This platform technology will be demonstrated by converting a highly active, but insoluble and protein binding, novel compound into targeted nano-formulations for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections with proven in vivo and in vitro safety. Furthermore, LeadtoTreat aims to identify novel synergistic combinations of antibiotics and potentiators and convert these into highly active targeted nano-formulations for treatment of MRSA infections. LeadToTreat will have significant impact on the future treatment of microbial infections, by demonstrating a pathway to co-delivery of synergistic combination of existing antibiotics as well a path way to revitalize the huge library of abandoned low-drugability lead compounds. From an innovation perspective, it is expected to also develop broadly applicable targeting tools (for MRSA, and roadmap for other indications). The project will be managed by SINTEF (Norway) involving Narodowy Instytut Lekow (National Medicine Institute, NMI, Poland) and NanoTag Biotechnologies GmbH (NTB, Germany).

Keywords: nanotechnology,biotechnology,microbiology,mrsa,formulation
Chiral bUilding Blocks with bRidged or Caged polyclic structures (CUBIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1999758.0
EU funding (EUR): 1999758.0
Participants: 1
Project status: SIGNED

“Drug candidates should have a higher proportion of Csp3 over Csp2 and Csp and a greater number of stereogenic centers”. That is essentially the message of F. Lovering et al. in their seminal article “Escape from Flatland” published in 2009 which induced a paradigm change in drug design. The first recommendation (higher proportion of Csp3) has opened a new field of research over the last 15 years, in a quest aiming at the synthesis and functionalization of small rigid polycyclic (bridged or caged) molecular scaffolds, used as building blocks in medicinal chemistry and particularly as bioisosteres of aromatics. This quest has strongly influenced academic and industrial research in organic and medicinal chemistry. However, the second recommendation (more stereogenic centers) was largely unmet due to the lack of efficient methods for the enantioselective synthesis of such chiral rigid polyclic structures. In this project, we will develop an array of synthetic methods involving diverse enantioselective cycloadditions reactions and cascade transformations to fill this essential gap in knowledge. Ultimately, we will apply these methods to the enantioselective synthesis of various bridged and caged polycyclic scaffolds, which could become the building blocks of the future in drug design. In particular, we propose to achieve the first enantioselective synthesis of a polysubstituted cubane scaffold, a long-standing challenge in asymmetric synthesis. We will also apply these synthetic approaches to the unprecedented enantioselective total synthesis of various polycyclic natural products. Knocking down the scientific barrier of enantioselective synthesis of bridged and caged rigid molecular scaffolds will have huge repercussions for the fields of organic chemistry and asymmetric synthesis, through the development of new synthetic methods and total syntheses, but also for medicinal chemistry and drug discovery, via the design of the next generation of building blocks.

Keywords: asymmetric catalysis cycloadditions total synthesis bridged structures
Antenna Systems Experts for 6G Non-Terrestrial Networks (ANTERRA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Sweden,Italy,France,Belgium
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 5112884.06
EU funding (EUR): 4201236.0
Participants: 14
Project status: SIGNED

Our society is on the brink of a new age with the development of new visionary concepts such as internet of things, autonomous driving, and coverage everywhere. This stimulates the use of new deployment concepts, such as Non-Terrestrial Networks (NTN), to support the wireless communication evolution. For 6G, a key use case which stands unaddressed by prior telecommunication generations, is that of coverage everywhere. A major candidate to solve this issue, is to deploy a network of satellites in an NTN configuration, which is front hauled by a high-gain gateway cell in order to serve rural and remote areas which up until now is lacking coverage. Here, especially novel energy efficient antenna systems are required to track fast moving satellites while meeting the cost targets of the consumer market. One of the major reasons for not addressing this thus far is the lack of expertise about non-terrestrial communication in the classical (terrestrial) telecommunication industry, which underpins the urgent need for a cross-disciplinary industrial doctorate network. ANTERRA establishes a unique and well-structured training network with leading R&D labs from European industries, universities and technology institutes in the domain of antenna systems for terrestrial as well as non-terrestrial applications. The 15 ESRs will form a research team that is embedded in leading industrial and academic R&D labs. The programme will strongly enhance the employability and career prospects of the ESRs by offering a high-quality consortium with in-depth training in the technical areas as well as a comprehensive set of transferable skills relevant for innovation and long-term employability. The ESRs will all spend at least 18 months of their time at industry, ensuring that the training includes a significant industrial experience and application.

Keywords: non terrestrial networks,radio architectures,high gain antennas,energy efficient highly integrated radio front ends,synchronization and beam finding
Supporting the Just transition for the Fashion sector (Just Fashion)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: Belgium,United Kingdom,Lithuania,Italy,Spain,Germany,North Macedonia,Portugal
Call: Cultural and creative industries for a sustainable climate transition (HORIZON-CL2-2024-HERITAGE-01, 2024)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 3926716.19
EU funding (EUR): 3754773.04
Participants: 20
Project status: SIGNED

“Just Fashion”, is set to develop a portfolio of approaches to support and accelerate climate transition in the fashion industry, by providing businesses in the partner countries with a reference framework and tools to shift their production methods, internal procedures and final products towards more sustainable models that are lower carbon, circular and socially inclusive. Just Fashion aims to address this problem by (1) mapping the current state of fashion and sustainability in Europe, (2) mapping and evaluating tools and on circular business models (3) create a process of interventions to support these tools and support existing networks in preparing MSMEs and SMEs for the new legislation on the European Green deal. 4 central elements of the projects: 1) Development of a new sustainability index as well as testing and refining several circular business model tools that are already in use in different areas and are already being tested in these countries. 2) Run 6 pilot cases from different regions focussing on different aspects of circularity (end of life, materials, zero waste prototyping, circular business models, recycling techniques, transparency/traceability, ...). 3) Update current instruments and tools in transformation & mitigation 4) Develop the necessary instruments to better prepare (M)SME's for European Green deals in terms of policy regulations (through buidling an AI support tool).

Keywords: fashion,circularity,business models,sustainability
Modelling trajectories and mechanisms of childhood hip dysplasia (HIPSTAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2499373.75
EU funding (EUR): 2499373.75
Participants: 2
Project status: SIGNED

With 40 million patients in Europe, osteoarthritis (OA) is the most common chronic and disabling disease. OA is incurable, and symptomatic treatments have limited effect. Therefore, prevention by identifying and targeting asymptomatic persons that develop a clear OA risk factor is sorely needed. Hip dysplasia is the strongest risk factor for hip OA. Hip dysplasia is a condition of mechanical instability of the hip caused by insufficient coverage of the femoral head (ball) by a shallow or obliquely oriented acetabulum (socket). This results in high cartilage stress, and subsequent hip OA. In Europe we screen for developmental hip dysplasia in infants (prevalence 2%), enabling early treatment. However, we discovered that hip dysplasia can (further) develop during skeletal maturation and thus remains unrecognized. In 1100 Dutch 9-year-old children we found a 6% and 26% prevalence of marked and mild hip dysplasia, respectively. Hip dysplasia can be influenced until the stage where hip growth plates close at about age 13. I propose a novel research program (HIPSTAR) where I will uniquely unravel the mechanisms behind late childhood hip dysplasia in order to pave the way for devising preventive measures that reduce the prevalence of adult hip dysplasia and, thus, hip OA. In a birth cohort of 8000 children (followed from foetal life until adulthood), I will first uniquely built a 5D growth model on how hip shape develops over time from age 2-18 years. I will gain novel knowledge regarding causal factors of dysplastic growth, and whether there are various phenotypes that have different underlying mechanisms. I also will study how and when dysplastic growth will already impact on the integrity of the young adult joint, and discover very early signs of joint aberration leading to OA. Finally, in a computational model, I will test the influence of loading factors on dysplastic growth mechanistically, and provide detailed information regarding the potential remedial options.

Keywords: osteoarthritis,hip,growth and development,risk factor,joint diseases,phenotype