Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Data Governance for Equitable and Sustainable Digital Food Systems (DIGIFOOD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1998860.0
EU funding (EUR): 1998860.0
Participants: 1
Project status: SIGNED

Across the world, digitalization has been heralded as the start of a new "agricultural revolution." Data collected from digital sensors implanted into soil, satellites, and mobile phones offer the possibility of gathering unprecedented amounts of data. Combined with predictive analytics of artificial intelligence, this data promises critical insights for governments, food producers, and the private sector to address the challenges of food insecurity and climate change. Yet with these new flows of data also come risks. Unequal capacity to collect and extract value from data can exacerbate structural power asymmetries in food systems, with important implications for human rights. To mitigate these risks, it is essential to establish robust data governance, itself no easy task. Agricultural data defy the legal categories that have guided data protection in other sectors. Moreover, most models of agricultural data governance have been developed in the Global North and may not be fit for the Global South, where smallholders make up the majority of food producers. This project, Data Governance for Equitable and Sustainable Digital Food Systems (DIGIFOOD), examines these emerging networks and practices of agricultural data governance through a transnational, comparative, and cross-national study of three countries leading agricultural digitalization and governance in the Global South—Kenya, India, and Colombia. The project breaks new ground by developing an innovative socio-legal and ethnographic approach for analyzing the technical, legal, and cultural dimensions of data governance. It will offer empirical insights into the impact of digitalization on agrarian relations, shedding light on struggles over power and authority within the context of the digital agricultural revolution. By doing so, it aims to make a substantial contribution to the normative evolution of governance standards to enable equitable and sustainable digitization of agriculture and food systems.

Keywords: legal anthropology,data governance,agrarian studies
Adaptation Solutions for Regional Climate Resilience (REGILIENCE-plus)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Coordination and support actions
Countries involved: Netherlands,Austria,Germany,Belgium,Ireland,Croatia,Portugal
Call: Bringing available and actionable solutions for climate adaptation to the knowledge of the regions and local authorities (HORIZON-MISS-2024-CLIMA-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 1998175.0
EU funding (EUR): 1998175.0
Participants: 9
Project status: SIGNED

The need: Despite their climate action, mission signatories still face major challenges in climate adaptation planning and implementation. Among specific needs to address the challenges and facilitate adaptation actions, the largest single need identified by 72% of the signatories was ‘knowledge’, replicated across most countries, geographical locations and types of regions. Strengths of the consortium: The REGILIENCE+ Consortium has demonstrated over the past 3 years its capacity to work together in providing coordination and support to climate adaptation Innovation Actions, as well as contributed significantly to the development of the Climate Adaptation Mission, the Mission Portal (e.g., inspiring and contributing to the tools database and the funding database). Expected outputs: Improved knowledge via 150 solutions in the form of case studies, adaptation options and tools included in online inventories (preferably Climate-ADAPT) and 70 multilingual communication products, services, and activities. Envisaged outcomes: Inclusion of inventory updates in mainstream climate adaptation knowledge platforms, and Use of communication products, services, and activities by MIP4Adapt, National organisations and initiatives (including National Adaptation Hubs), Regional and Local authorities, and other entities addressing climate adaptation. Established procedures for the inclusion of inventory updates are in place and used beyond the timeline of REGILIENCE+. Aimed impacts: Smarter, swifter and more systemic adaptation in European regions and local communities, due to improved access to and replication of available and actionable solutions.

Keywords: inventory updates climate adaptation solutions climate adaptation knowledge platforms adaptation mission
Constrained convergence: does pleiotropy constrain convergent alpine adaptation? (CONstrainCONverge)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 309768.48
EU funding (EUR): 309768.48
Participants: 2
Project status: SIGNED

Is evolution predictable? In CONstrainCONverge, I aim to understand evolutionary mechanisms governing predictability in adaptive evolution, by asking why some genes are more likely reused by adaptation than others. Despite a rich theoretical background, systematic analysis of the mechanisms underlying convergence is lacking in complex multicellular organisms. That limits application of convergent evolutionary concepts in repeated evolution of socio-economically relevant traits such as resistance to pathogens, pesticides or pollution. To fill in this gap, I will study genetic constraints of convergent adaptation towards stressful alpine environments in plant model genus Arabidopsis. Eight independently evolved populations of alpine Arabidopsis provide a unique model of environmental adaptation, allowing to leverage an unprecedented range of genetic and experimental resources to address fundamental evolutionary questions. During my PhD I characterized this system from a population genomic point of view, preparing a ground for experimental genetic validations. In the outgoing phase, I will bring this experience to the host lab of Prof. Peichel at the University of Bern (UBERN), an expert in the evolutionary genetics of convergence in fishes. Systematic training in the host lab and three international research visits will broaden my bioinformatics and experimental skills. I will learn new multidisciplinary approaches bridging the fields of evolutionary genomics and molecular genetics through the combination of transcriptomics, statistical genomics, and functional experiments. I will return to Charles University (CU) to share the newly gained skills with local researchers and gain further training in functional genetics and transferable skills under the supervision of Prof. Lafon Placette, aiming to improve my teaching and leadership skills and establish my own research group in evolutionary genetics, a virtually non-existent field in Czech research environment.

Keywords: adaptation,convergence,population genomics,gene regulatory networks,pleiotropy,fitness,arabidopsis
Healthy Working environments for all Ages: An evidence-driven framework (WAge)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Norway,Spain,Portugal,Denmark,Poland,Malaysia,United Kingdom
Call: Evidence-based interventions for promotion of mental and physical health in changing working environments (post-pandemic workplaces) (HORIZON-HLTH-2023-ENVHLTH-02, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 5442312.5
EU funding (EUR): 5442312.0
Participants: 9
Project status: SIGNED

The WAge project will develop and validate the first comprehensive framework for assessing and understanding the roles and interactions between physical and psychosocial risk factors across age groups through robust modelling and policy-relevant evidence gathering. Through the proposed framework, the project will pave the way for designing, implementing and validating effective multi-level intervention strategies and policy changes for workers of all ages at the individual and organizational level. The project focuses on a question that has high societal relevance and is timely because the proportion of employees under adverse physical and psychosocial work environments is likely to increase as organisations, businesses, and workers have to adapt to post-pandemic working environments in an ageing Europe. WAge is proposing a concept that is addressing the factors related to the health and overall wellbeing of workers across age groups. One of the main aims of the proposed action is the generation of integral, policy-relevant evidence that are vital for the improvement and update of occupational health but also for this HORIZON Europe call. In WAge, the gathering and utilization of evidence within decision-making spaces will be based on representation and accountability of policymaking, bringing multiple perspectives and knowledge through democratic participation into decision-making processes across the project, from data collection, and management, to analysis, and implementation.

Keywords: policy relevant evidence,participatory research,work demands,intervention,data sovereignty
New system-driven bioremediation of polluted habitats and environment (NYMPHE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Greece,Netherlands,Czechia,Germany,Slovakia,Portugal,Belgium,Romania,Poland,Switzerland
Call: Environmental services: improved bioremediation and revitalization strategies for soil, sediments and water (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5702902.8
EU funding (EUR): 5499973.5
Participants: 18
Project status: SIGNED

The objective of Nymphe is to develop bioremediation/revitalization strategies based on the assembly of systems of available and new biologics (enzymes, microorganisms, bivalves and earthworms, plants and their holobiont) developed and applied on matrices from different EU contaminated sites: groundwater, sediments (hyporheic zone), wastewater as well as industrial, and agricultural soils. The assembly of systems is guided using predictive microbial interaction models in the microbiome of the actual site matrix to be decontaminated. The best systems of biologics are reintroduced at the contaminated sites (4 plus 1 site for confined tests using genomically edited biologics). Nymphe target at least 90% removal of the pollutants occurring at the sites, e.g. plastics and pesticides in the agricultural soil, and chlorinated solvents/total petroleum hydrocarbon in groundwater and sediments of the industrial site. Besides, biologics and systems benefit from the development of platform technologies to: assemble stable consortia (adhesin+complementary auxotrophies), accelerate the evolution of the microorganisms, increase mobility of degradative plasmids, genomically edit bacteria to produce evolved enzymes, produce enzyme systems with recycling of cofactors, control the spatial distribution of biodegraders (3D-printing), protect them in harsh environments, facilitate redox processes by electromicrobiology, design self-sustaining redox biocatalysts. The bioremediation/revitalization strategies undergo a full assessment: ecological and environmental risk analyses (chemical, ecotoxicological and supportive analyses e.g., function and biodiversity of the microbiomes), technology risk analysis, life cycle assessment, life cycle cost, cost-efficiency analysis, biosafety & regulatory constraints analysis, and societal analysis to be finally benchmarked with current solutions. The ecological status of the bioremediated sites shall be closer to Natura 2000 specifications

Keywords: bioremediation,pollution,revitalization,biotechnology,microbiome,detoxification,
International Conference on Research Infrastructures 2024 (ICRI 2024)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Australia
Call: International Conference on Research Infrastructures – ICRI 2024 (HORIZON-INFRA-2024-ICRI-IBA, 2024)
Start date: 2024-03-01
End date: 2025-02-28
Duration (months): 12.0
Total project cost (EUR): 300000.0
EU funding (EUR): 300000.0
Participants: 1
Project status: CLOSED

A proposal under the Horizon Europe - Work Programme 2023-2024 Research Infrastructures to deliver the International Conference on Research Infrastructures 2024 in Brisbane, Australia on 3-5 December 2024. The proposal is prepared by the event delivery partner, the Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia's national science agency.
Late-stage photocatalytic functionalization of alkenes and 1,3-dienes (LateFun)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

The late-stage functionalization (LSF) of bioactive compounds is currently a hot topic in the chemistry community, as it allows for the rapid and divergent construction of molecule complexity and avoids the need for time-consuming de novo synthesis. This is especially relevant in the fields of drug discovery and medicinal chemistry where the fast identification of structure-activity relationships is crucial. Especially intriguing in this context are alkenes and 1,3-dienes, as they are frequently occurring motifs in natural products and drug molecules including important antibiotics and antivirals. However, methods for the introduction of a broad variety of functional groups via the LSF of these moieties remain underdeveloped. LateFun aims to create new chemical space by developing a first-in-class methodology for the incorporation of a highly versatile functional handle via the LSF of alkenes and 1,3-dienes, whose well-established subsequent transformations will allow for the rapid assembly of diverse structures. Applying this innovative protocol to the LSF of complex natural products and drug molecules will be of great importance and impact, going beyond the current state of art. The real-life applications of this cutting-edge research proposal will be explored during a secondment phase in Novartis (Basel), providing for valuable industry insights and interdisciplinary aspects. The host’s expertise in late-stage functionalization of bioactive molecules using catalytically generated carbyne equivalents perfectly complements the applicant’s strong background in photocatalysis and therefore guarantees two-way-transfer of knowledge between the host group and the ER (Experienced Researcher). The successful implementation of this action in the highly international and interdisciplinary environment of ICIQ and Novartis will enable the fellow to develop a unique research profile and will be crucial in building an independent academic career.

Keywords: photocatalysis,alkenes,1 3 dienes,hypervalent iodine chemistry,carbyne equivalent,late stage functionalization,enantioselective catalysis
How do diazotrophs shape the ocean biological carbon pump? A global approach, from the single cell to the ecosystem (HOPE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2493821.0
EU funding (EUR): 2493821.0
Participants: 1
Project status: SIGNED

Diazotrophs regulate marine productivity in 60% of our oceans by alleviating nitrogen limitation, contributing to carbon (C) sequestration through the N2-primed Prokaryotic C Pump (PCP). Yet we don’t know how much diazotroph-derived organic C (OC) is exported to the deep ocean, which prevents robust predictions of how the ocean contributes to CO2 sequestration and climate change mitigation. This knowledge gap is due to the multiple and complex pathways by which diazotrophs are exported to the deep ocean, which quantification and drivers of variability are impossible to capture with current methods. HOPE will bridge this gap thanks to a new isotopic technique I developed and to a coupling between lab and in situ approaches examining processes occurring at different spatiotemporal scales, and capable of capturing both transient and seasonal features of the PCP. HOPE will: 1.Determine how various diazotrophs aggregate, sink and are remineralized by using an automated experimental water column I designed for this proposal 2.Decipher by which pathways diazotroph-derived OC is exported to the deep ocean thanks to a pioneer approach combining single-cell isotopic analyses, in-depth microbiological characterization of sinking particles and geochemical budgets 3.Investigate how environmental drivers control the whole process, from the surface diazotroph community up to their eventual export to the deep ocean, by deploying a cutting-edge autonomous platform, unique as it performs synoptic measurements both in and below the euphotic zone at high resolution (hourly/daily). In its final stage, HOPE will use the generated data to provide global, spatially resolved estimates of the contribution of diazotrophs to overall OC export. Based on my expertise at the interface between microbial oceanography and geochemistry, HOPE has the potential to deliver a multidisciplinary and ground-breaking knowledge leading to potential scientific-based recommendations to fight climate change.

Keywords: n2 fixation,diazotrophs,cyanobacteria,export production
Dissecting the Functional Role of Mucosal IgA Clonal and Glycoprofiles for Effective Humoral Mucosal Protection (D-MAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Sweden,Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1486245.0
EU funding (EUR): 1486245.0
Participants: 4
Project status: SIGNED

Numerous mucosal vaccines and IgA-based monoclonal antibodies aimed at a robust immunity within the respiratory tract are in development to combat viral endemics and pandemics. However, investigations into humoral immunity have predominantly focused on circulating antibodies, particularly those of the IgG isotype. This has left a significant void in our understanding of the role of mucosal IgA proteoforms in conveying effective immune protection. This crucial knowledge gap deprives vaccine and antibody development of crucial determinants or immune characteristics to replicate. In response to this, we will conduct in-depth investigations of mucosal IgA including in vitro and in vivo functional evaluations. We will capitalize on recent advances in liquid chromatography and mass spectrometry-based approaches for the detailed characterization of mucosal IgA clonal repertoires and glycosylation profiles, a field that has remained completely unexplored until now, B-cell receptor sequencing, monoclonal IgA glycoengineering and in vitro functional assays. We will take advantage of our unparalleled biobank of human nasal secretion samples with clear documentations of infection outcomes on an individual level. What sets our approach apart is thereby the unprecedented molecular-level characterization of IgA, directly linked to their in vitro functionality and pre-defined clinical outcomes, which clearly surpasses current state-of-the-art. By harnessing our in-depth characterization of mucosal IgA coupled to functional traits, we will generate IgA templates with enhanced binding and neutralization capabilities as well as functionally advantageous Fc effector potencies. Our overarching aim is to provide molecular-level blueprints for protective monoclonal IgA-antibodies, enabling the fine-tuning of vaccine formulations and monoclonal antibody generation with a higher degree of accuracy, ultimately enhancing their efficacy and safety.

Keywords: mucosal immunity,iga clonal repertoire,iga glycosylation