Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Therapeutic Allele Engineering: A novel technology for cell therapy (TALE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 2397082.0
EU funding (EUR): 2397082.0
Participants: 2
Project status: SIGNED

We are currently witnessing a revolution in cell therapies that are routed in decades of basic research in genetics, cell biology and immunology. A deep understanding of mammalian, and in particular immune, cells is currently being translated into highly efficient cell-based therapeutics. Technologic breakthroughs in genetic and genome engineering are further fueling the generation of customized, high precision therapies that are based on cells as “smart drugs”. For instance, reprogramming immune killer cells to recognize B cell leukemias resulted in unprecedented clinical responses in treatment-resistant and relapsed patients. However, currently only very few, highly selected patients benefit from these developments. A fundamental problem of today’s cell therapies is that transferred cells cannot be distinguished from host cells. We have developed “allele engineering”, a new technology that solves this challenge. Here, we outline how allele engineering will improve the safety and efficacy of cell therapies. We will 1) generate a non-viral, DNA-free safety/shielding switch 2) develop a radically new curative approach to acute myeloid leukemia 3) rationally design a safe allele engineering solution for human therapy and 4) use allele engineering as a curative therapy of scurfy syndrome, a lethal monogenic autoimmune disease. Allele engineering enables completely new treatment strategies and can be applied to any surface protein. Therefore, I anticipate that the results will have a major impact on the field.

Keywords: cell therapy,car t cell,safety switch
Mirror Mirror on the Wall, which Higgs is the oddest of them all: Exploring the Top-Higgs Interconnection with ATLAS (TheHiggsAndThe7Tops)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-10-01
End date: 2025-03-31
Duration (months): 66.0
Total project cost (EUR): 1999998.0
EU funding (EUR): 1999998.0
Participants: 1
Project status: SIGNED

With the ground-breaking discovery of a new scalar particle, the Higgs boson, in 2012 by ATLAS and CMS, the standard model (SM) of particle physics has been completed. Despite this success, many open questions on the fundamental laws of nature remain unanswered. Among these are how exactly particles acquire their mass and why there is more matter than antimatter in the universe. One of the most promising avenues to approach these questions is to explore the relation between the Higgs boson and the heaviest known elementary particle: the top quark. Due to its large mass, the top is expected to play a special role in the mechanism of electroweak symmetry breaking. In order to shed light onto this mechanism, understanding the coupling between the top and the Higgs in great detail and exploring the charge and parity (CP) nature of the Higgs are essential. While the SM Higgs boson is CP-even, many models beyond the SM require a CP-odd component. Higgs-top couplings are expected to provide an unambiguous probe of CP-mixed states. I will explore for the first time all processes in which a direct determination of the top-Higgs interconnection is feasible, in particular events where the Higgs is produced in association with 1, 2 and 4 top quarks. These are among the most challenging channels at the LHC. I will pioneer a comprehensive programme, consisting of the development of powerful event-reconstruction methods and improved boosting techniques, allowing the first exploitation of novel variables in a beyond-state-of-the-art cross-process analysis, thus unravel the CP-properties in the top-Higgs interaction. The ultimate goal of the project is the precise direct measurement of the top-Higgs Yukawa coupling, and the first determination of the CP-nature of the Higgs boson in fermion interactions. Confronting these results with the SM and models that go beyond the SM will yield an unprecedented insight into the origin of mass of elementary particles.
Education as an instrument for liberation in Mozambique and Timor-Leste — histories of solidarity and contemporary reflections (EDULIBERA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: CLOSED

EDULIBERA proposes to study the ‘education as a liberation instrument’ dimension of the independence movements in Mozambique and Timor-Leste, uncovering the histories of encounters and solidarity between the two peoples from 1974 onwards. The objective is to understand how the circulation of ideas and people between these two places could potentially form the base of common principles around education and social emancipation. Also, it will analyse the role of these memories and silenced histories in education and knowledge production today, in the contexts of their post-conflict experiences, and the extent of the fulfilment of the anti-colonial movements imagined futures. In terms of training and career advancement, the objectives will be to broaden the researcher’s expertise and participation in academic networks, consolidate her research profile as one of independence and promote her longer-term integration in the academic profession. As an early career researcher who is returning to Portugal after a period conducting her PhD studies in Australia and fieldwork in Timor-Leste, this will constitute a significant support to her reintegration in the European research community. Benefiting from the supervision of an experienced academic and engagement with a research group at CES, this will improve the researcher’s capacity to produce high-impact publications, take part in international collaborations and conferences, opening new career possibilities. EDULIBERA’s innovative research significance translates into studying alternative knowledges, formed through subaltern historical processes in the global south, opening up space for more critical and democratic views of the world. It is crucial to promote these knowledges about solidarity and dignity that stem from post-conflict and transnational histories at a time when Europe is facing ethnical and religious intolerance and the revival of fascist groups in politics and society.

Keywords: subaltern histories and epistemologies,africa asia solidarity,education and emancipatory struggles,independence movements,timor leste,mozambique
Hybrid Rocket Technology Exploration (HyTeX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

The space industry is going through a transformational phase, creating unprecedented levels of growth for space and nonspace actors/industry. In the next years a significant increase in the market of small satellites up to 500 kg is expected. The HyImpulse start-up has been created recently and intends to bring to the market the key technologies for a game-changing, unique, low risk, innovative small launcher, with a 500 kg payload capability to LEO. The launcher will be based on a combination of novel and established technologies, using inherently safe hybrid propulsion (paraffin/LOX propellants). These engines combine a liquid oxidizer with a solid fuel thus enabling to benefit from both bi-liquid and solid technologies and advantages. Unlike solid and liquid technologies, hybrid engines did not benefit from large investments and research in the past due to the inherent complex phenomena occurring into their combustion chamber. This is however changing with the new space constraints which make hybrid motors serious candidate for future applications. This research fellowship aims at bringing hybrid propulsion from the current state of development to a fully mature technology enabling the flight of sounding rockets and small launchers. The action will allow the elaboration of novel measurement and analysis techniques to study the fuel regression rate, the wax composition properties & the engine performances and stability. In addition to the scientific investigations of complex and coupled phenomena occurring in the combustion chamber of a hybrid engine, an innovative wax manufacturing process will be optimised in collaboration with colleagues from HyImpulse. The most original aspect of the fellowship is the combination of scientific investigations of complex phenomena with innovative technical developments that are required to make hybrid propulsion technology competitive in the coming years.

Keywords: hybrid rocket propulsion,fuel regression rate measurement,paraffin wax manufacturing process,liquid oxygen,engine performance and stability
PEER LEARNING OF INNOVATION AGENCIES ABOUT INNOVATION SUPPORT IN SMES IN TRANSNATIONAL BUSINESS VALUE CHAINS (SME VALUE CHAINS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Sweden,Belgium
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2015-09-01
End date: 2016-04-30
Duration (months): 8.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

This proposal offers a peer learning excercise between 3 innovation agencies from small regions in the South, the North and the Centre of Europe. By means of the proven Twinning + methodology they'll focus on the common challenge of the design of innovation support for SME’s operating in crossborder business value chains. In small regions, business value chains cross easily the regional borders, so SMEs have to be agile to fit these in order to grow. Stimulating business value chains is one of the policy actions of the EU Strategic Work Program. This proposal aims to 1. learn about this sub-type of SMEs 2. investigate the current mix of instruments to stimulate innovation and entrepreneurship 3. understand the criteria of ‘value chain-fitness’ 4. discuss novel approaches in the public innovation support system and make recommandations for other innovation agencies. The mutual policy learning and exchange of ‘good practices’ will enhance the transfer of good practices in SME support which is one of the specific challenge of the work programme. Futhermore, since innovation agencies are important intermediaries to SMEs, the peer learning will contribute to make public support for innovation in the EU more effectively. An information “exchange” workshop with testimonials from SMEs and economic/innovation experts will give some insights in the real needs of those SMEs. Subsequently, the participants will do a small field research in their region. The information gathered will be displayed on a digital platform working as a community of practice. Finally, the participants perform the peer learning in a 2days session collaborating together in an equal relationship and discuss novel approaches in relation to the topic. In the end, a Design Options Paper documents the implementation options and guidelines that the partners in the challenge have experienced and would recommend to other innovation agencies.

Keywords: transnational business value chains
Constructing an Alliance for Value-driven Cybersecurity (CANVAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Coordination and support actions
Countries involved: Germany,Germany,Germany,Spain,Ireland,Germany,Switzerland,Switzerland,Belgium,Finland,Switzerland,Netherlands
Call: Value-sensitive technological innovation in Cybersecurity (H2020-DS-2015-1, 2015)
Start date: 2016-09-01
End date: 2019-10-31
Duration (months): 38.0
Total project cost (EUR): 1569050.0
EU funding (EUR): 1000000.0
Participants: 12
Project status: CLOSED

The growing complexity of the digital ecosystem in combination with increasing global risks entail the danger that enforcing cybersecurity may bypass other fundamental values like equality, fairness or privacy, whereas downplaying cybersecurity would undermine citizens’ trust and confidence in the digital infrastructure. Technology developers as well as legal and philosophical scholars and empirical researchers have dealt for many years with cybersecurity issues, although from very specific angles. What is missing is community-building that unifies these perspectives from the presupposition that technology development in cybersecurity should incorporate European values and fundamental rights. Constructing this community – an alliance for value-driven cybersecurity – is the central aim of the CANVAS consortium. CANVAS consists of partners from different scientific traditions – ethical, legal, empirical and technological – with unique competences and broad contact networks such that they can serve as “seed crystals” for community-building. The consortium will take three domains of application with unique value-profiles and complementing cybersecurity exigencies – the health system, finance, and police / national security – as starting point for outlining problems related to value-driven cybersecurity. Using a three-step process, CANVAS will (1) structure existing knowledge, (2) design a network for exchanging knowledge and generating insights across domains, and (3) disseminate the insights gained through three means: A reference curriculum for value-driven cybersecurity with a focus on industry-training, briefing packages for policy stakeholders, and a MOOC (massive open online course) on value-driven cybersecurity. Furthermore, the alliance that should result from this community-building will allow for self-organization among alliance members for tackle specific research questions that emerge out of knowledge exchange in future proposals.

Keywords: value sensitive design,cybersecurity,ethics,ict law,mooc,privacy,reference curriculum,european values
Effectiveness of Terrestrial Protected Areas in Reducing Human Pressure (PRESSURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Human impacts on nature have led to massive biodiversity declines. Protected areas (PAs) have been suggested as one of the most important tools to reduce human pressure and protect biodiversity. In this project I will advance our understanding of the effectiveness of terrestrial PAs in reducing human pressure and improve current knowledge on how to measure human pressure, by specifically addressing three objectives: 1) To understand how management quality affects PAs ability to reduce human pressure, 2) To reconciling remote sensed maps of human pressure with field observation of the impact of human threats, and 3) To improve existing maps of human pressure by including data of key threats to biodiversity (e.g. natural resource use and invasive species). The foundation of the project will be the Temporal Human Pressure Index (e.g. a temporal Human Footprint), the World Database of Protected Areas, and a global database on Management. The three objectives will apply different state-of-the-art statistical approaches including propensity matching and general linear mixed effects models to achieve these ambitious objectives. The project is expected to lead to three high impact peer-reviewed papers as well as min two popular science papers, and one policy brief. The project will help me develop new data and skills instrumental to achieving my career goals in academia after the fellowship. I will be hosted in the conservation group at the University of Cambridge, under supervision of Professor Andrew Balmford who is one of the world’s leading conservation scientist and an expert on how to understand human pressure in relation to biodiversity. Professor Neil Burgess will be my supervisor while seconded at WCMC. He is a world leading expert on management effectiveness and has years of experience working on pressure and PAs. This proposal represents a frontier in conservation science and is of very high relevance to the EU and global conservation policy.

Keywords: protected area,management effectiveness,pressure,threat,counterfactual
Sonaca WING flap process Development (SWING)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,France,France
Call: Shielding/High-lift composite thermoplastic flap manufacturing, tool design and manufacturing & process definition (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 1170467.5
EU funding (EUR): 941535.5
Participants: 4
Project status: CLOSED

SWING project aims to develop a material/process/design solution for a shielding flap for hybrid laminar flow control on wings of large passenger aircraft. The project target is to develop an In Situ Consolidation thermoplastic process to outperform existing process in terms of structural and economic performance. Indeed, Hybrid Laminar Flow Concept will lead to more complexity in the structure of the wings and their accessories, and therefore an efficient process to manufacture flaps are needed to enable implementation of such system with an acceptable cost. From a technical point of view, several challenges stay on the development road : • Selection of a thermoplastic composite pre-impregnated tape that fulfil both the design, the process and the economic requirement. • Process parameter control strategy to guarantee in situ consolidation of composite with the nominal performance of the material for the targeted complex geometry • Efficiency of tape laying to match with the economic equation. Efficiency includes the maximum laying speed and the gestion of start and stop (loss of time, scraps…) • Assembly solution to create a closed wing section that include the ribs and possibly other reinforcement (for mechanical fastening, at trailing edge….). SWING aims at overcoming these challenges with significative achievement to allow the integration of the thermoplastic flap in demonstrator wings of hybrid laminar flow control. The Krueger flap develop inside the project will impact the CO2 emissions of the Large Passenger Aircraft demonstrator through two ways : by reducing the weight of the flap thus the fuel consumption and by allowing aerodynamics optimization.
Compact - Additive Layer Manufactured Air Oil Heat Exchanger (C-ALM AOHE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom,United Kingdom
Call: Compact Matrix Air Oil Heat Exchanger (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-05-01
End date: 2022-10-31
Duration (months): 42.0
Total project cost (EUR): 1888810.01
EU funding (EUR): 1191905.0
Participants: 3
Project status: SIGNED

The C-ALM AOHE project will design, develop, manufacture and test a compact air-oil heat exchanger for next generation geared VHBR/UHBR turbofan engines. The work will include: • Design a C-ALM AOHE incorporating novel geometry and construction with step change technology attributes • Create a thermal model of the proposed design using computational techniques • Build a thermally representative C-ALM AOHE • Performance test the C-ALM AOHE concept and validate the thermal model • Refine the C-ALM AOHE design and build an optimised C-ALM AOHE • Test and validate the C-ALM AOHE in line with the Topic Manager's requirements The C-ALM AOHE project will deliver a fully validated air-oil heat exchanger to TR 6, MCRL4 and MRL6 with a heat load of 80kW and a dry weight of significantly less than 10kg that can directly flow into follow on flight demonstrator and NPI programmes.

Keywords: additive,heat exchanger