Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the nanobiophysics of virus-host interactions in 3D cellular systems (SingViroPhys)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2867346.0
EU funding (EUR): 2867346.0
Participants: 1
Project status: SIGNED

The current pandemic demonstrates how viruses represent a major threat for human health. Viral infection is a complex multistep process involving both the virus and the host cell machinery. The very first stage consists of landing and binding of the virus, followed by host cell entry, and then the release of the viral genetic material into the cell. Entry pathways are largely defined by the preliminary interactions between viruses and their receptors at the cell interface. Elucidating this complex interplay is a crucial step towards establishing a full picture of the infection process and may lead to the discovery of new antiviral drugs targeting viral entry. Our current knowledge of virus-host interactions mainly relies on the use of cancerous model cell lines cultured in 2D that far from mimic the 3D in vivo conditions of tissue, such as cell heterogeneity and complex organization. Hence, there is an urgent need to develop an innovative platform to monitor and quantify the molecular forces and dynamics at play during the entry pathways in such complex environments. The ambition of this proposal is to unravel virus-host interactions under physiologically relevant 3D conditions by combining single-virus atomic force microscopy and optical tweezer techniques. By means of cellular models of increasing complexity, we will decipher the complex relationship between the organization and heterogeneity of epithelium and the early stages of viral infection. At the frontiers of nanobiophysics and virology, this project will push the limits of advanced nanotechniques to understand the molecular mechanisms of virus entry in unprecedented 3D in vivo conditions. This project will have strong scientific and medical impacts. In virology, it will strongly enhance our molecular understanding of virus-host interactions. In medicine, our new methodology will contribute to the identification of new compounds that target viral infection and the innate immune response.
Repurposing a human drug to treat Alzheimer’s disease (Re-TauAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Alzheimer’s disease is a major cause of disability among older adults and represents substantial financial and human costs to patients, families and societies worldwide. Currently there is no cure for Alzheimer’s disease. Thus, novel effective treatments need to be developed that target the root causes of Alzheimer’s disease, in particular the pathogenic accumulation of the protein tau. During our ERC project, we achieved a breakthrough by demonstrating that an approved human drug efficiently inhibits pathogenic tau accumulation in several pre-clinical assays. The identified FDA/EMA-approved small molecule is orally bioavailable, safe in humans and reaches the brain at high concentrations. It is the aim of this proof of concept project to provide further pre-clinical validation of the drug and to pursue the needed steps towards IPR protection and commercialization. Because no disease-modifying therapy currently exists for AD, bringing the novel repurposed drug closer to the market promises an outstanding high gain.
Intelligent Reading Improvement System for Fundamental and Transversal Skills Development (iRead4Skills)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Portugal,Belgium,Luxembourg,Spain
Call: Conditions for the successful development of skills matched to needs (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 2699586.25
EU funding (EUR): 2699585.0
Participants: 8
Project status: SIGNED

The project iRead4Skills has as main objectives: • to assess and reduce reading skills gaps in low literacy adults for the development of fundamental and transversal skills by i) establishing and monitoring the relation between improvement in literacy skills and improvement in other fundamental skills (such as numeracy or ICT) and transversal skills (such as technical skills, communication skills, team-working skills, foreign language skills, customer handling skills, problem solving skills, learning skills and planning and organization skills) as well as motivation, citizenship and well-being; ii) providing an intelligent reading system that evaluates texts complexity and suggests appropriate readings according to the user literacy level. The system would also be used to assist trainers and text producers to create or adapt texts with the appropriate level of complexity with regard to their target readers. • to support the adoption and diffusion of innovation in the way low literacy adults acquire and sustain transversal and durable skills, matching the always evolving needs of the job market, by developing and putting to work an open access system, available for both trainers and trainees, that allows for advanced digitally-enabled training and skills development. Reading skills are fundamental to acquire technical and scientific knowledge, either in formal education and training contexts, as Adult Learning (AL), either in practical and empirical working contexts, as when companies provide written specific information and/or instructions to their workers. People with low literacy skills are less able to acquire and sustain transversal and durable skills needed to stay apace with the changing job market and to lead meaningful and complete lives.

Keywords: reading skills,innovation,ict tools for education,complexity analysis
Co-benefits and synergies between biodiversity conservation, poverty alleviation and climate change mitigation from a social-ecological systems perspective (CoBioPovCli)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,China
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 2
Project status: SIGNED

CoBioPovCli addresses the question of how to conserve biodiversity, alleviate poverty, and mitigate climate change simultaneously, which are interrelated challenges that threaten human and environmental well-being. The importance of this topic is highlighted by the current context of the global COVID-19 pandemic and the Russia-Ukraine war, which have exacerbated these problems and their impacts on human and environmental well-being. The main gaps in this topic are: (1) lack of comprehensive data, especially on the dynamics of socio-ecological systems, (2) lack of integrated knowledge, and (3) lack of holistic approaches that consider co-benefits and synergies. CoBioPovCli aims to overcome the limitations and gaps in the current state-of-the-art by developing an integrated spatial planning approach that can achieve win-win synergies between biodiversity conservation, poverty alleviation, and climate change mitigation from a social-ecological systems perspective. CoBioPovCli will use literature, models remote sensing data, and other data sources to construct and apply the spatial planning approach, based on case studies, spatial analysis and scenario simulation. CoBioPovCli will generate new knowledge, data and solutions that are conceptually novel, scientifically rigorous and policy-relevant. It will enhance our understanding of the multiple values of biodiversity and its contributions to human well-being under changing climatic conditions. It will provide evidence-based recommendations and best practices for promoting more integrated and sustainable approaches that benefit both people and the planet. CoBioPovCli will also enhance Europe’s scientific and technical capacity and excellence in the field of co-benefits and synergies between biodiversity conservation, poverty alleviation, and climate change mitigation, as well as contribute to Europe’s global leadership and influence in addressing these interlinked challenges.

Keywords: poverty alleviation,climate change mitigation
Interoperability Network for the Energy Transition (IntNET)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Germany,Austria,Ireland,Spain,Belgium,Italy,France
Call: Interoperability community (HORIZON-CL5-2021-D3-01, 2021)
Start date: 2022-05-01
End date: 2025-10-31
Duration (months): 42.0
Total project cost (EUR): 4995541.5
EU funding (EUR): 4995541.5
Participants: 13
Project status: SIGNED

Interoperability depends on cooperation of multiple domains. While for the energy sector technical interoperability is quite well established, interoperability of functions and businesses needs more attention. Even when standards are defined and interoperability models agreed, framework setters, product developers and users need to agree on their deployment and make sure that solutions are compatible with definitions. The Interoperability Network for the Energy Transition project (IntNET) establishes an open, cross-domain community bringing together all stakeholders relevant for the European energy sector to jointly work on developing, testing and deploying interoperable energy services. The community will be formally established to exist beyond project life-time. With a comprehensive, FAIR knowledge platform and a series of attractive events it guides those who deal with the heterogeneous interoperability landscape of energy services. To support ongoing harmonization of energy services, IntNET will institutionalise an assessment methodology and maturity model (IMM). Involving legal and regulatory bodies from the beginning and constant exchange of interoperability initiatives and standardization bodies will build a deep consensus on how European governance and industry can foster interoperability at all levels. Starting from an extraordinary well balanced and connected consortium of researchers, framework setters (e.g., ministry and EU wide associations), standardisation and communication experts, IntNET’s community approach guarantees wide outreach. IntNET will establish a framework for interoperability testing in ongoing projects and harmonize test procedures in a network of closely cooperating, self-sustained testing facilities. Energy service solutions based on the novel IMM and tested according to the IntNET certification process will be awarded with a widely known quality seal for interoperable smart grid and energy products (working title: “IntNET approved").

Keywords: interoperability,interoperability maturity model,community,test,standardisation,certification
Optimal High Resolution Earth System Models for Exploring Future Climate Changes (OptimESM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Sweden,Denmark,France,Germany,Finland,Italy,United Kingdom,Netherlands,Spain,Austria,Cyprus
Call: Development of high-resolution Earth system models for global and regional climate change projections (HORIZON-CL5-2022-D1-02, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 7691803.96
EU funding (EUR): 7691803.96
Participants: 22
Project status: SIGNED

OptimESM will develop a novel generation of Earth system models (ESMs), combining high-resolution with an unprecedented representation of key physical and biogeochemical processes. These models will be used to deliver cutting-edge and policy-relevant knowledge around the consequences of reaching or exceeding different levels of global warming, including the risk of rapid change in key Earth system phenomena and the regional impacts arising both from the level of global warming and the occurrence of abrupt changes. OptimESM will realise these goals by bringing together four ESM groups with Integrated Assessment Modelling teams, as well as experts in model evaluation, Earth system processes, machine learning, climate impacts and science communication. OptimESM will further develop new policy-relevant emission and land use scenarios, including ones that realise the Paris Agreement, and others that temporarily or permanently overshoot the Paris Agreement targets. Using these scenarios, OptimESM will deliver long-term projections that will increase our understanding of the risk for triggering potential tipping points in phenomena such as, ice sheets, sea ice, ocean circulation, marine ecosystems, permafrost, and terrestrial ecosystems. OptimESM will further our understanding of the processes controlling such tipping points, attribute the risk of exceeding various tipping points to the level of global warming, and develop a range of techniques to forewarn the occurrence of tipping points in the real world. Artificial Intelligence (AI-) methods for statistical downscaling will be developed and applied to improve our understanding of the effect of long-term global change and tipping points on regional climate, particularly extreme events. New knowledge and data from OptimESM will be actively communicated to other disciplines, such as the impacts and policy research communities, as well as the general public. This knowledge will provide a solid foundation for actionable science-based policies.

Keywords: high resolution,earth system processes,emission scenarios,projections,tipping points,safe landings,regional climate,extremes,machine learning,science communication,policy guidance
Research Ethics and integrity for the GREEN transition (RE4GREEN)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Germany,Ireland,Netherlands,Austria,Denmark,Greece,Belgium,Korea, Republic of,Spain,South Africa,Japan
Call: Research ethics for environmental and climate technologies (HORIZON-WIDERA-2023-ERA-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 2999343.75
EU funding (EUR): 2999343.75
Participants: 15
Project status: SIGNED

There is growing awareness of the importance of having all sectors of society adapt to face a range of global environmental and climate challenges, taking into account intergenerational justice. These challenges require developing an encompassing framework for research and innovation (R&I) to address environmental and climate ethics and integrity issues, which relate not only to R&I involving potentially significant environmental and climate repercussions (e.g., R&I in the area of electro-magnetic fields), but also R&I specifically aiming to develop knowledge and technologies to address environmental and climate challenges (e.g., geoengineering or biotechnology in food systems). RE4GREEN’s main goal is to contribute to a European Research Area (ERA) ethics and integrity framework for research and innovation activities designed to support the transition to a sustainable economy and society as envisioned by the European Green Deal. While R&I has too often been part of the problem of environmental degradation and biodiversity loss, a central pillar of the European Green Deal and associated legislation is to promote new technologies and sustainable solutions to reach net zero emissions in the EU by 2050, and advance a range of other climate and environmental objectives. Based on a bottom-up approach that uses the social lab methodology to reflect diverse stakeholder expertise, RE4GREEN will develop operational research ethics and integrity guidelines, recommendations and training materials and programmes for researchers, ethics and integrity experts and advisors and ethics review boards to make sure R&I activities more holistically contribute solutions toward the Green Transition.

Keywords: climate change climate ethics environmental ethics intergenerational justice green transition european green deal research and innovation biodiversity,social lab value pluralism
'UNMET' - Uncovering Mechanisms and Establishing Strategies to Target Vessel Co-Opted Colorectal Cancer Liver Metastases (UNMET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

An estimated 25-50% of colorectal cancer patients will encounter liver metastasis during their illness. Tumor vessel co-option is a non-angiogenic mechanism whereby tumors, rather than forming new blood vessels (a process known as angiogenic growth), hijack pre-existing blood vessels in the affected organ. Standard anti-angiogenic therapy (AAT) is ineffective against vessel co-optioned tumors. This process has been linked to unfavorable patient outcomes. The exact mechanisms distinguishing vessel co-option remain elusive. Preliminary data suggest that metastatic cancer displaying the vessel co-option phenotype increased in gene expression, regulated by Lymphoid enhancer binding factor 1 or LEF1 protein, which is a key mediator of the Wnt/β-catenin signaling. The dysregulation of the Wnt pathway can activate target genes that promote cell proliferation and survival. In this proposal, I hypothesize, that inhibition of the Wnt signaling (e.g. by blocking LEF1), will change the properties of vessel co-optioned tumors and improve the effectiveness of conventional treatment for liver metastases. Patient-derived organoids, obtained from hospitals, will be used to validate whether the inhibition of LEF1 will impact the vessel co-option phenotype, making it more susceptible to AAT. Advanced microscopy techniques, like Atomic force microscopy and Scanning ion-conductance microscopy, will facilitate monitoring the decreased stiffness of vessel co-opted tumor cells, leading to improved AAT delivery. By using humanized patient-derived organoid xenografts with inhibited Wnt signaling, I will monitor tumor growth, its phenotype, and the response to AAT in vivo. Furthermore, I aim to pinpoint diagnostic markers for vessel co-option tumors using blood tests and computed tomography (CT) scans. Utilizing artificial intelligence tools, I plan to analyze CT scans of liver patients to better predict metastatic tumor subtypes and treatment responses in the future.

Keywords: colorectal cancer liver metastases vessel co option sprouting angiogenesis anti angiogenic therapy
Digitalisation of Biomanufacturing of Plasmids for the Development of Advanced Therapy Modalities (DIG4BIO)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Portugal,Denmark,Germany
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 1482125.0
EU funding (EUR): 1482125.0
Participants: 4
Project status: SIGNED

Digitalization of biDigitalisation of biomanufacturing is key to increasing efficiency, reducing costs, and ensuring quality control in the production of biopharmaceuticals and advanced therapies. Dig4Bio aims to: i) advance the research capacity and profile of the coordinator IST (PT) in the field of digitalisation of biomanufacturing, and ii) strengthen the research management and administrative skills of IST. This will be achieved through a strategic alliance with experts in digital biotechnology from PROSYS, DTU (Chemical and Biochemical Engineering, DK) and lab automation TU Berlin (Chair of Bioprocess Engineering DE). Dig4Bio includes 6 Work Packages (WPs). WP1 (Advancing scientific capacity) and WP2 (Enhancing research management capacity) focus on stepping up the scientific and research management skills of IST through tailored training (workshops, training schools, digital tools, short term visits). In WP3 (Joint research activities), Dig4Bio partners will collaborate on a pioneering R&I initiative that addresses the question: “How to develop and incorporate a digitalisation framework in the conceptual design, research and development of biomanufacturing processes”. Attention is focused on Escherichia coli-based manufacturing of plasmid DNA, a biomolecule that is gaining increased relevance as a biological (e.g. DNA vaccination, in vivo gene therapy), and as a raw material in the manufacturing of gene/cell therapies (e.g. mRNA vaccines). WP4 (Clustering Activities) aims to foster close ties, synergies and knowledge exchange between the consortium and stakeholders, whereas WP5 (Communication and Dissemination) aims to disseminate findings and promote awareness of the field. WP6 (Coordination and Management) provides the necessary administrative support to ensure the successful and timely execution of all project components. The expected outcomes for Dig4Bio include the elevation of IST profile in digitalisation of biomanufacturing and in research management.

Keywords: biomanufacturing digitalisation automation modelling