Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The integration of mechanical and chemical signals in neuronal guidance (MECHEMGUI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany,United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2023-12-31
Duration (months): 67.0
Total project cost (EUR): 2468520.0
EU funding (EUR): 2468520.0
Participants: 2
Project status: SIGNED

During the development of the central nervous system (CNS), neurons extend axons through a crowded environment along well-defined pathways to reach their distant targets. It isA start date of 1st June 2018 is being requested to enable the PI to complete a number of current commitments and put the necessary arrangements in place to enable an efficient start up phase of the project. evident that attractive and repulsive guidance cues in the tissue provide important biochemical signals to guide growing axons along their paths. This can only be part of the story, however, as it is still not possible to predict axonal growth patterns in vivo. In a recent breakthrough discovery, we provided in vivo evidence that neurons also respond to mechanical cues, such as local tissue stiffness, suggesting that mechanical signals are likely an important missing part of the puzzle. However, mechanically activated signaling pathways are currently poorly understood, and how neurons integrate mechanical and chemical signals to result in proper outgrowth is unknown. By investigating how mechanical signals control neuronal growth and pathfinding, this proposal will close this comprehension gap. By combining state-of-the-art approaches in physics, engineering and biology, we will, for the first time, identify mechanosensitive molecular mechanisms that regulate neuronal growth and guidance in vitro and in vivo. In particular, we will investigate how mechanotransduction cascades (1) directly modulate axon growth by inducing local changes in cytoskeletal dynamics, and (2) indirectly lead to alterations in axon outgrowth by modulating chemical signalling pathways. Ultimately, we will develop a computational model based on our findings, which will lead to a predictive framework for understanding axon pathfinding in the developing brain. The proposed research challenges current concepts in developmental biology and is very relevant to many other areas in biology. Our results will not only shed new light on the complex control mechanisms of cellular growth and motility, but could also lead to novel biomedical approaches aimed at facilitating neuronal re-growth and regeneration in the damaged CNS.

Keywords: mechanobiology,biophysics,mechanotransduction,forces,tissue stiffness,atomic force microscopy,traction force microscopy
SCALESCRAPERS - how to support the growth of scale-ups to only sky is the limit (SCALESCRAPERS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Hungary,Poland,Slovenia,Slovenia
Call: Peer learning of innovation agencies (H2020-INNOSUP-05-2016-2017, 2017)
Start date: 2017-10-02
End date: 2018-07-01
Duration (months): 9.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 5
Project status: CLOSED

The system of business environment institutions (BEI) plays an important role in the diffusion of technology process and assists the innovative entreprenuership development. Its support is especially important in the emerging areas of innovation like scale-ups. This group of SMEs is considered to be another way of innovation but still faces many difficulties in development. At the same time, according to the research results pointed in documents shown in section 1.3.2 and data available in the work program despite the number and variety of BEI they are still not sufficient enough for the appropriate innovation stimulation (includint effective support for scale-ups) in the partners states, which at the same time affects the level an quality of innovation and the competitiveness of the European economy. That is way TARR, TPlj, CTRIA, BARR and IRP decided to join their forces and by sharing knowledge and experience try to contribute in solving problem mentioned above. The main objective of this project is to develop through the lifetime of the project (9 months) basing on the scaleups analysis and the evaluation of current system tools and instruments, recommendations for improvement of the scaleups development support system for entrepreneurship policy makers and specialized business environment institutions operating as scale-ups supporters followed by dissemination of gained knowledge and experiences. The goals of the project will be achevied with the use of Twinning Advanced method. It assumes the cooperation of equal partners. Therefore it is possible not only to exchange and disseminate existing solutions but also to develop tecommendations for the new ones, which will eventually become godd practices in supporting first of all scale-up and secondly the innovation processes in general. Thus the main and specific objectives the work-flow of SCALESCRAPERS will comprise a one phase process, whoch is the development and dissemination of Design Options Paper.

Keywords: start ups,scale ups,innovativeness,innovation agencies,peer learning
Ubiquitin Chains in Viral Infections (CHUbVi)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Switzerland,Switzerland,United Kingdom
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-03-01
End date: 2026-02-28
Duration (months): 72.0
Total project cost (EUR): 7649848.0
EU funding (EUR): 7649848.0
Participants: 3
Project status: SIGNED

Viruses such as Influenza A (IAV) and others remain one of the greatest threats to human health and society. Despite their danger and widespread prevalence, the molecular mechanisms of how they infect mammalian hosts and evade the immune system remains poorly understood. Recent studies from our team implicate two common proteins – HDAC6 and unanchored ubiquitin chains – in host cells as key mediators of viral entry via the aggresome processing pathway. This discovery offers a new line of investigation for understanding and preventing viral infections. By identifying the pathways and interactions involved in this infection process, we will provide new molecular targets for the development of broad-spectrum antiviral compounds. Multidisciplinary studies by a team consisting of a molecular biologist, a virologist, and a chemical biologist will use a diverse set of tools to validate these pathways and gain fundamental knowledge about their regulation. To achieve this, detailed studies on the exact nature of the ubiquitin chains needed to activate HDAC6 will allow the development of biochemical and cellular assays of Influenza A infection and enable the determination of the precise mechanism and the downstream cellular pathways necessary for viral infection. The chemical synthesis of labeled ubiquitin chains will support detailed structural studies and a clear understanding of how they are formed and packaged into infectious viral particles. The strong possibility that numerous other virus types also utilize this pathway will be tested with life-threatening agents of current concern including Zika, Dengue, Ebola, and MERS viruses. By demonstrating – with both biological approaches and small molecule compounds – that blocking these cellular processes in cells and animal models reduces viral infection, this project will provide a wealth a novel insights and the basis for the development of a new generation of anti-viral therapies.

Keywords: ubiquitin chains,hdac6,influenza virus,aggresome pathway,proteasome,stress granules,proteostasis
Designing of Novel Mixed Anion Compounds as High Voltage and High Energy Density Sodium-ion Battery Cathodes (Mixed Anion Cathodes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-30
End date: 2023-05-18
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Sodium-ion batteries (SIBs) are being developed and explored as potential electric storage for the grid applications due to infinite resources for sodium at cheaper price. The major impediment for its commercialization is unavailability of cathodes that possesses high output voltage and delivers high energy density. The state-of-art SIB positive electrodes consist of cathodes with the highest output potential (≤ 3.5 V) exhibiting lower specific capacities (150 mAh/g) while V2O5 cathodes delivered high specific capacity (225 mA/g) at low potential (2.5 V). Therefore, it will beneficial to design cathodes with high output voltage and capacity to build high energy density SIBs. In this project, the above drawbacks are mitigated by designing a new class of mixed anion compounds, vanadium oxyfluorides as novel cathode materials which are expected to deliver high specific capacities at higher operating voltage (≥ 3 V). These compounds are synthesized by partial fluorination using a non-hazardous organic reagents and novel one-pot microwave assisted methods. The as-prepared materials are characterized to identify their chemical compositions and crystallography using TEM, neutron and synchrotron diffraction techniques. These cathodes are subjected to electrochemical testing in a typical CR2032 coin cells. The solid state NMR is used to study the local structure and Na+ mobility inside cathode host while in-situ XPS provides insight into change in electrode composition at various stages of cycling. The electrochemical pulsed technique and impedance spectroscopy are used to determine diffusion coefficient of Na+ and electrochemical mechanism. The optimized materials will be further tested in a pouch cells resembling a real device. Therefore, this project elucidates the designing of a new class of mixed anions cathodes with high output voltage (≥ 3 V) and deliver high specific capacity (225 mAh/g) for fabricating high energy density SIBs (675 Wh/kg) for efficient grid storage.

Keywords: mixed anion compounds,high voltage cathodes,microwave synthesis,solid state nmr,in situ,sodium ion battery
Hybrid Battery energy stoRage system for advanced grid and beHInd-de-meter Segments (HYBRIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Spain,Italy,Spain,Spain,Serbia,Belgium,Belgium,France,France,Netherlands
Call: Hybridisation of battery systems for stationary energy storage (H2020-LC-BAT-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3995822.5
EU funding (EUR): 3995822.5
Participants: 15
Project status: SIGNED

HYBRIS' basis is the optimisation of advanced hybrid systems as high-performant, cost-effective and environmentally-friendly solutions in microgrid applications. HYBRIS is an integrated industrially driven action, that will answer to this challenge in 4 key points: - Viability and cost effectiveness: of the use and integration of novel HEES system coupled with innovative microgrid system local RREE generation and loads, (in particular residential, tertiary buildings and EV charges stations). Achieved by the integration and validation of a suite of technologies, tools and methods enabling their easy application and massive deployment. - Technical: pursuing the technical optimization of the HEES system in 3 use case applications covering respectively 1) Energy services in island grids 2) Energy services in private grids 3) EV charging stations in e-mobility, - Optimization and integraton. - Validation: by using the 3 demonstration sites as open case studies representing the 3 differrent use case applications and situations found throughout Europe, to leverage knowledge, key exploitable results, adapted business models and market-oriented dissemination for maximizing impact and wide adoption of these novel heating and cooling technologies and approach. HYBRIS features a fully systematic, collaborative and integrated approach to the development and deployment of innovative battery based hybrid storage sytemm, coupling diverse and complementary breakthrough TRL 5-6 technology assets brought by leading industrials, universities and RTOs, plus ICT tools for viable and cost-effective optimization and further market introduction. All will reach TRL6 by the demonstration and validation of its concepts in 3 use cases applications in 3 pilot sites in 3 four countries

Keywords: hybridisation,bms and ems,li ion,redox,organic redox flow batteries orfb,energy efficient storage systems,lifecycle,cost reduction,energy density
The world’s “First and Cleverest Space-Based ULD-Tracker” for Airports and Airfreights in EU and worldwide. (STAP-WATCHER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Main Task is the development and commercialization of STAP ULD-Watcher, a RFID and satellite-based chip to enable worldwirde and real-time localization of ULDs where no additional infrastzructure is needed. The core of STAP is a technology which is in line with IATA air cargo regulations. The value chain includes various groups: airports (implementation partners), airfreight companies (short term customers), transport organizations (customers), forwarding companies (potential supporter of the technology), ground service companies at airports (crucial partners for installation, service and proof of concept), manufacturer of ULD transport vehicles and ULD lifters (potential strategic partners) and second source service provider which are working with tracking data (potential strategic partners). The main customer benefits and USPs of STAP-Watcher are the user friendliness (unique and simple plug-in-and-play system working both indoor and outdoor), highly accurate monitoring as well as the unmatched price (30% cheaper than any closest competitor product in market), which offers a unique return on investment time of 1.2 -2 years, depending on the size and special needs of a specific airport. Further advantages over state-of-the-art systems include small system size, equipped additional sensors, fully automatic documentation (designed for very small to extremely large airport & cargos), no need of addition infrastructure and smart control through actual AT-patented technology. A global PCT is filed in September-2019 to cover whole EU and some core countries worldwide. The airlines and cargo forwarder including ground handlers save upto 16% time and labour costs using STAP watcher compared to currently used state-of-the-art technologies. Furthermore, our open protocol interface is compatible to any Airport and logistics management and automatic decision management system worldwide.
Global Governance and the European Union: Future Trends and Scenarios (GLOBE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Spain,Israel,Indonesia,Germany,Belgium,China,United Kingdom,Costa Rica
Call: Trends and forward-looking scenarios in global governance (H2020-SC6-GOVERNANCE-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 10
Project status: CLOSED

GLOBE will approach the issues identified in the call focusing on global problems, which has been defined as strategic priorities in the 2016 EU Global Strategy: trade and development, security and the politics of climate change. We will include also the challenges of migration and global finance as additional areas, which go even beyond the call. The strength of our consortium lies in first-class academic expertise, as composed by top-level European and international scholars, which guarantees not only high-level analysis of the past and present problems of global governance but also contributes to determining solid forward-looking trends and scenarios. We will include participants from all over the EU as well as Argentina, Indonesia, and China. Regarding each of the global problems selected, we will identify the major roadblocks for effective and coherent global governance, by multiple stakeholders, and in a multi-polar world. GLOBE will be based on 11 workpackages, which will be divided into two clusters. While the first cluster will focus on these problems one by one, the second cluster will move to a more general and prospective level and will elaborate more on risks and drivers for the transformation of current global regimes in the domains examined. While the first cluster will provide policy-makers, academics and the general public with an analytical grip on the state of play in global governance, supported by new theoretical and methodological approaches, the second cluster will equip national and European policy-makers with tools to identify constraints and possibilities in several global governance scenarios in the years 2030 and 2050. Taking into account these alternative scenarios, we will recommend strategies on how the EU might promote enhanced global governance and deal with their future challenges and gridlocks.
Mechanism of allosteric regulation of SHP2 phosphatase and its role in cancer and genetic diseases: a multidisciplinary computational, structural and biological approach (MARS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

SHP2 is an SH2 domain-containing protein tyrosine phosphatase with a key role in the RAS-MAPK signaling pathway. Germline mutations in PTPN11, the gene encoding SHP2, occur in 50% of individuals affected by Noonan syndrome, whereas somatic mutations in this gene cause more than 30% of cases of juvenile myelomonocytic leukemia (JMML), and are more rarely found in other hematologic malignancies and tumors. The X-ray structure of SHP2 shows a multidomain architecture compatible with an allosteric regulatory mechanism: under basal conditions SHP2 is inactive, because its N-terminal Src homology 2 (N-SH2) domain blocks the active site of the protein tyrosine phosphatase (PTP) domain. Binding of the N-SH2 domain to a phosphopeptide (PP) ligand causes SHP2 activation by favoring dissociation of the N-SH2 and PTP domains. To characterize this dynamic transition at the atomic level, will be used a combination of state of the art computational methods coupled to X-ray scattering (XS) and biochemical assays. Major goals of the proposed studies are to explain how disease-associated mutations perturb the regulatory events controlling SHP2 function, and design new molecules able to inhibit SHP2 binding to signaling partners. The project implementation is guaranteed by the expertise of the Experienced Researcher (ER) in molecular dynamics (MD) studies of allosteric mechanisms that is complemented by the consolidated expertise of the host institution (HI) in the combined use of MD and XS, together with the external collaboration of an Italian expert in SHP2 biology and a US specialist in XS. Overall, the proposed research will provide a deeper understanding of SHP2 regulation, and dissect the molecular mechanisms implicated in its functional dysregulation in human disease. The planned studies are expected to provide a new class of lead compounds to treat SHP2-associated diseases. Finally, a new computational approach for the design of peptidomimetic inhibitors will be developed.

Keywords: molecular dynamics simulations,allosteric regulation in proteins,protein tyrosine phosphatases,genetic diseases,noonan syndrome,rasopathies
Postimperial Memories, Gender and Trauma in the Anthropocene: A Change of Feminist Perspective on Turkey (POGETA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 157355.52
EU funding (EUR): 157355.52
Participants: 1
Project status: SIGNED

The increasing currency of the Anthropocene era demands new ways of thinking about grief and trauma which are both personal and cultural experiences. As E. Ann Kaplan proposes, the concept of “pre-traumatic stress syndrome” describes how cultural representations of accelerated environmental degradation generate “climate trauma,” which is accompanied by its own psychological condition (2015). Further, a host of slowly unfolding environmental crises confront us with “slow violence,” which is neither sudden nor spectacular but instead incremental with calamitous repercussions for years or decades or centuries. Much of the current narrative on the Anthropocentric age relies on the realm of Western and European from human-centered, techno-focused, and masculinist lens, overlooking the feminist roots of work on the Anthropocene. This novel project proposes feminist and queer study of Anthropocene trauma in post-imperial Turkey and its European diasporas by investigating how public intellectuals remember and dramatize grief and trauma regarding the lingering environmental effects of the Ottoman Empire, the environmental aftermath of war and genocide, climate trauma, and other forms of slow violence in modern Turkish literature. Divided into five work packages, the objectives of this project can be synthesized as follows: mobilizing a new taxonomy of trauma and grief in contemporary Turkey pertinent to the Anthropocene; developing feminist and queer forms of insight into the Anthropocene conversation through post-Ottoman context; being the first of its kind that simultaneously acknowledges and transcends current environmental concerns and one that relates back to gender, race, ethnicity, and class in Turkey and its European diasporas. This project corresponds well with 2020 EU policies regarding environment and climate action and the Horizon 2020 Work Programme since it studies a wide range of psychoanalytical and physical response to our dire environment predicament.

Keywords: anthropocene,grief,trauma,climate trauma,slow violence,ottoman empire,modern turkey,turkish literature,feminist and queer critique