Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploring the salivary transcriptome of Ixodes ricinus, the Lyme disease vector in Europe, and the potential role of its cystatins in pathogen transmission (RICYSTVACANT2010)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Ixodes ricinus abundance and its infection prevalence with Borrelia burgdorferi s.l. (the Lyme disease agent) have led to an increased risk of human exposure to tick bites and Borrelia infection in Europe. Acaricide based control of this vector has caused serious repercussions, thus raising the importance for the development of anti-tick vaccines. My previous work has demonstrated that guinea pigs vaccinated with a salivary cystatin of Ixodes scapularis, the Lyme vector in the USA, are partially protected against tick blood feeding and that the same protein facilitates Borrelia transmission as well. I. ricinus cystatin ortho-/homologues are not studied yet, partially due to the limited genomic information for this tick. Hence, this study aims to enrich our knowledge of I. ricinus salivary transcripts by considering the entire complex tick lifecycle and by performing massive 454 pyrosequencing, a relatively novel, highly efficient and cost effective technology. In parallel, library screens will be carried out to identify I. ricinus secreted cystatins. Their tissue specificity and abundance will be estimated, while gene silencing will evaluate their contribution to tick feeding success. Recombinant cystatins will be 1) biochemically characterised for their inhibitory effect on different cysteine proteases and 2) tested for their role in vertebrate host immunomodulation/pathogen transmission. Next, vaccination studies will investigate their potential to provide protection against I. ricinus and/or Lyme disease transmission. Overall, the proposed project is expected to enhance my collaboration with the scientific community in the United States and Europe, thus promoting the transfer of knowledge and technology in the field of tick functional genomics. It is also expected to reveal novel candidate salivary antigens for anti-tick vaccine development and thus to contribute towards a concerted effort for the control of a vector borne disease in Europe.

Keywords: health sciences,ixodes ricinus,arthropod disease vector,tick salivary glands,ests,454 pyrosequencing,cystatin,rna interference,lyme disease,anti-tick vaccine,dual antigen,host immunity
QUANTITATIVE VULNERABILITY ASSESSMENT FOR THE EVALUATION OF LANDSLIDE RISK IN INHABITED AREAS (RISK-LESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

Landslides constitute a major threat in mountainous areas. In recent years the risk assessment for landslides has shifted from qualitative to quantitative. The components of the risk are the hazard and the vulnerability of the exposed elements. Although for the quantification of the hazard there is considerable ongoing research, the work for the structural and societal vulnerability is limited and the evaluations are mostly judgmental or empirical, resulting in high subjectivity. The objective of this proposal is the development of analytical methodologies to be applied for the quantification of the vulnerability of buildings and people that are threatened by rockfalls and slides. Two load-bearing systems will be considered: reinforced-concrete, RC, and masonry structures. Additionally, the societal vulnerability will be calculated based on the potential extent of the building damage. The methodologies will be applied to selected case-studies. For the evaluation of the structural response of the buildings, structural analysis methods will be used. For RC structures the response of the load-bearing system will be simulated using models for high stain-rate impacts and/or the finite-element, FE, method. The latter will also be used for masonries, as well as failure criteria that are compatible with the FE analysis output. Where applicable, the potential for progressive collapse following local failure will be investigated through FE analysis, too. The vulnerability of the structures to landslides will be quantified using probabilistic vulnerability indices or thought probabilistic fragility curve diagrams. For the quantification of societal vulnerability a step-by-step methodology for the construction of frequency-fatalities (F-N) curves will be developed for each landslide type, using event trees and considering its dependence on structural vulnerability.

Keywords: natural sciences,landslides,rockfalls,vulnerability,structures,societal,buildings,damage,loss,people
Local desingularization of quasi-excellent schemes. (ILU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2014-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Gabber recently proved a weak local uniformization theorem that states that for any quasi-excellent integral scheme X with a valuation v there exists an alteration Y->X (i.e. a proper generically finite morphism between integral schemes) such that v lifts to a valuation on Y with a regular center. Moreover, one can achieve that the degree of the field extension k(Y)/k(X) is coprime with a fixed prime number l invertible on X. My recent inseparable local uniformization theorem refines this when X is a variety. In this case, it suffices to consider alterations with a purely inseparable extension k(Y)/k(X). The main aim of this project is to develop in the context of general quasi-excellent schemes (including the mixed characteristic case) the technique that was used to prove the inseparable local uniformization theorem. In particular, this should lead to the following strengthening of Gabber's theorem: it suffices to consider only alterations Y->X such that k(Y) is generated over k(X) by (p_i)^n-th roots where each p_i is a prime number not invertible on X.

Keywords: algebraic geometry,resolution of singularities,local uniformization,quasi-excellent schemes
Efficient Painting & Enhancement of Hand-drawn Cartoon Animations (TOONPAINT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

The aim of ToonPaint project is to develop practically usable tool that will make the traditional cartoon animation production pipeline less tedious and so cost effective. In addition to that it will also develop a new enhancement technique to increase visual richness of resulting imagery while retain the look of hand-drawn animation. The project has two main research objectives: (1) develop an efficient variant of LazyBrush algorithm proposed in the previous FP7 IEF project CARToon of which advantage is that it is applicable to a broad class of different drawing styles and requires significantly less manual effort as compared to previous approaches, (2) deliver new interactive tool allowing artists to paint with hand-drawn textures like with homogeneous colors and so enable creation of new painting styles. Besides research objectives the project also proposes a number of complementary activities to support lasting professional integration of the applicant into the host institution. They include establishing own research group, collaborating with industry, improving writing & publishing skills, teaching own master degree course, and preparation of international FP7 ICT project.

Keywords: computer graphics,image processing,intelligent interfaces
Quantum phases of Fermi-Fermi, Bose-Bose and Bose-Fermi mixtures of atomic gases at ultracold temperatures (ATOMIC MIXTURES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The Dr. Iskin will undertake theoretical research in condensed atomic and molecular physics. He will investigate quantum phases of two-species Fermi-Fermi, Bose-Bose and Bose-Fermi mixtures of atomic gases at ultracold temperatures. There are four main problems in this proposal. The first problem is about creating and observing a spatially modulated superfluid phase with characteristics of an Fulde-Ferrell and Larkin-Ovchinnikov (FFLO) type superfluidity in trapped atomic Fermi-Fermi mixtures. The second problem is about the phase diagram of the two-species Bose-Hubbard model, and their observation in atomic Bose-Bose mixtures. Both of these problems are highly popular in the field, and Dr. Iskin has already made a great progress on them. The third problem is about the limiting case of light-atom--heavy-atom mixtures, particularly those which can be described by light-heavy (Fermi-Fermi, Bose-Bose, Bose-Fermi and Fermi-Bose) Falicov-Kimball models. Dr. Iskin will apply the renormalization group theory to all 4 of these models. Finally, the last problem is about heteronuclear molecules, and creation and observation of a new phase of matter, i.e. ferroelectric superfluidity.

Keywords: ultracold atomic physics,bose-einstein condensation,optical lattices,superfluids,superconductors
RAPID SCANNING AND AUTOMATIC 3D RECONSTRUCTION OF UNDERWATER SITES (3DUNDERWORLD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Cyprus
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-12-01
End date: 2014-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The primary objective of this project is the development of an innovative hardware and software solution for the rapid scanning and 3D reconstruction of objects. The system will address the complexities and problems associated with the data acquisition, processing and reconstruction of objects situated underwater. The development of such a system will enhance the techniques available to underwater archaeologists and exploration groups in general, since it will significantly accelerate the documentation and mapping process. More importantly, the goals of the project will advance and directly promote the underwater exploration industry in Cyprus which is currently limited to small and ill-equipped archaeological exploration groups. Moreover, the project aims at promoting collaboration among research organizations and public-benefit organizations in order to produce an innovative product. The collaboration between the UCY and private archaeological institutions specializing in underwater explorations will combine the technological expertise with the experience of working underwater and will produce significant new advancements in the area in terms of both knowledge and technology. This collaboration will set the foundation for further cooperation between the two disciplines which will play a significant role into the development of both sciences. Furthermore, the dissemination of the project’s results to international scientific communities will place Cyprus among the countries that demonstrate noteworthy activity on both disciplines involved. The project will provide a useful tool for both training new scientists, as well as informing the wider public on underwater archaeology.

Keywords: technological sciences,computer engineering,computer graphics,computer vision,3d modeling,rendering
Molecular mechanism of calcium entry in the immune system (CAV IN IMMUNE SYSTEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-06-01
End date: 2015-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

T-lymphocytes require calcium entry though the plasma membrane for their activation and function. Recently, several routes for calcium entry through the T cell plasma membrane after activation have been described. These include CRAC channels (Calcium Release of Activated Channels), TRP channels (Transient Receptor Potential) and inositol-1,4,5-trisphosphate receptors (IP3R). Herein we are proposing the emergence of a new fourth route for calcium entry, composed of Cav channels (also known as L-type voltage gated calcium channels) and their regulator scaffold protein AHNAK1 (AHNAK/Desmoyokin). In excitable cells, such as neurons or muscle cells, Cav calcium channels constitute the major route for calcium entry. We have previously published that both helper (CD4+) and killer (CD8+) T cells express high levels of Cav1 alpha1 subunits (alpha 1S, -1C, -1D and -1F) and AHNAK1 after their differentiation and require these molecules for calcium entry during an immune response. This proposal aims to study the molecular mechanism by which this pathway is induced and functions. My preliminary evidence suggest that Cav channel calcium currents are induced by TCR stimulation, not by voltage depolarization, as described in excitable cells. Further studies proposed here are required to study this phenomenon. In this proposal, we will describe the observations and open questions, which ultimately suggests the involvement of multiple consecutive routes for calcium entry into lymphocytes, one of which is apparently mediated by Cav channels and AHNAK1.

Keywords: calcium signaling,cav calcium channels,ahnak1,ahnak2,cav1.1,scaffold proteins,immune response,t lymphocytes
Control of Turbulence (COT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2013-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The applicant researcher will do numerical studies to understand how to control or delay turbulence in boundary layer flows. This will be mainly carried out by Direct Numerical Simulations (DNS) of the Navier-Stokes equations. To initiate the DNS we intend to use, as initial conditions, the nonlinear travelling wave solutions (TWS) for the boundary layer flow that the applicant discovered during his IE-fellowship, which served as an initial phase of a long-term plan of understanding turbulence. The TWS are suitable initial conditions which have been suggested to be crucial for the understanding of turbulence and for its control. They are also important since they have stable manifolds but also a few unstable manifolds whose trajectories usually relaminarise or go turbulent. The aim is to consider a mode that sits on the unstable manifold as an initial condition and force the resulting flow trajectory to revert to laminar rather than turbulence using control strategies. The main idea of the proposed research is to use ideas from Nature and mimic the behaviour of plants and animals in order to develop ideas on how to control turbulence. Various strategies are planned to be studied to realise their suitability. The major goal is to produce clear steps forward in this branch of turbulent research. In terms of achievements the outcome of the research will be several research papers disseminated in leading international journals; furthermore and more importantly, the research will pave the way for ideas on how to manipulate turbulence in the laboratory and in industrial applications. The proposed research suits well with current research at the University of Genova and goes along the line of the fellow’s aspirations and academic interests. At the University of Genova the applicant researcher will find the ideal environment to develop and broaden further his scientific skills in fluid mechanics, stability theory, control, biomimicry and parallel computing.

Keywords: physical sciences,technological sciences
Design and Implementation of Optimal Management Systems for European Fisheries (DIOMFISH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The purpose of this research project is to develop an optimal management mechanism for the economic and social sustainability of European fisheries. Throughout the project, development and feasibility of a rights based management mechanism which efficiently allocates the fishing rights in Member States will be investigated. This mechanism will not have a high data demanding characteristic and will also be adaptable to other regions of fisheries in the third countries. Currently, Common Fisheries Policy (CFP) is the European Union`s instrument for the management of fisheries and aquaculture. As the third section in the Green Paper on the reform of the CFP pointed, European fisheries are eroding their own ecological and economic basis due to overfishing. Therefore, objectives to achieve sustainable fisheries have not been met overall and policy reform is needed to ensure that CFP will reach its objectives. The proposed mechanism will surely help to successfully implement the principles and objectives of the CFP by aligning the interests of the fishermen and those of the Commission. Moreover, the planned study has the potential to significantly improve the currently applied traditional fisheries management systems. Successful adaptation of the proposed management mechanism under the future of the CFP will promote sustainable fisheries in the EU.

Keywords: social sciences,economics,fisheries,optimal management systems,sustainable development,resource allocation,mechanism and market design
Imaging dendrites across wake and sleep: fiberoptic measurements of calcium activity in freely behaving animals (PERISLEEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The aim of this project is to look at changes in dendritic calcium activity during sleep and how these changes are influenced by waking experience in freely behaving animals. Sleep promotes brain plasticity and processes dependent upon plasticity (i.e. memory consolidation). But the cellular events that mediate these effects are poorly understood. We hypothesize that sleep promotes brain plasticity by increasing synaptic activity locally. We will test this hypothesis by looking at changes in in vivo dendritic calcium transients during sleep (Aim1) and sleep-dependent cortical plasticity (Aim2) in freely behaving animals. This will be achieved by combining EEG/EMG polysomnography recording and fiberoptic imaging techniques. More specifically, we will look at changes in calcium activity from the apical tuft dendrite of layer 5 pyramidal neurons. Dendrites are the main site of information processing and integration therefore changes observe over the sleep-wake cycle will contribute to a better understanding of synaptic function in the intact brain (Aim1). Changes in dendritic calcium levels are also directly linked to neuronal activity and can predict the polarity of plastic changes (e.g. synaptic potentiation vs. depression). Therefore, we expect that challenging the brain during wakefulness will modify dendritic activity during subsequent sleep. To test this hypothesis, we will quantify dendritic calcium activity during sleep following 2 different experience-dependent plasticity paradigms leading to either potentiation (enriched environment) or depression (monocular deprivation) in primary visual cortex (Aim2). The proposed research would be the first to assess directly the effect of sleep, experience-dependent plasticity and sleep-dependent plasticity on in vivo dendritic calcium activity in freely behaving animal.

Keywords: calcium,sleep,dendrite,in vivo,cortical plasticity,enriched environment,monocular deprivation,rodent,fiberoptic