Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ClimAte neutRal INitiatives for GrowiNg heAlTh and care Unmet REquirements (CARING NATURE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Italy,Cyprus,Finland,Greece,Belgium,Netherlands,France,Romania,Germany,Spain
Call: Environmentally sustainable and climate neutral health and care systems (HORIZON-HLTH-2023-CARE-04, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6024842.5
EU funding (EUR): 5999517.5
Participants: 20
Project status: SIGNED

Green transition is the behavioral intention of health and care providers (HCPs) even in presence of growing healthcare request after COVID-19. However, it requires operational tools to be carried out rapidly with optimal processes and low service costs. CARING NATURE’s (CN) 5 HCP, 5 innovation SMEs, 1 SDO, 2 industries and 5 Universities will construct and implement 10 healthcare specific solutions for carbon emissions and pollution (CEP) reduction demonstrated in 33 use cases. The 10 CEP-reduction solutions tackle main production sources on which HCP have exclusive control and were they act as principal actors of transition: building energy demand will be addressed through: reduction of environmental impact of construction and renovation, and utilizing AI-powered energy management; reduction and valorization of medical, food and water waste through a HCP tailored pyrolysis plant prototype and an on-site waste food digestion and drying system; reduction of patient/visitors travel through next generation telemedicine. Sustainability transitions require transversal staff and Governance commitment: Staff engagement through participatory methods for Communities of Practice will be explored and systematized. Governance capability of HCPs, policy makers and investors urgently needs an operative framework since to evaluate interventions no simple measuring system of HCP environmental impact exists. CN framework consists of a decision support system based on information sharing, HCP specific social life cycle assessment and life cycle cost and sustainable finance evaluation models together with a reporting model compliant with EU Corporate Sustainability Reporting Directive (CSRD). Governance bodies and other stakeholders will benefit from an HCP specific eco-friendly approach to reengineering of processes for enforcing sustainability based on the Green Lean Six Sigma methodology. Opportunities for standardization will be identified and reported.

Keywords: environmental sustainability,waste management,energy management,building management,sustainability governance,telemedicine,artificial intelligence,knowledge management
Advancing Hydrogen Storage in Lined Rock Caverns - From Materials to Market (HyCavern)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Norway,Germany,Netherlands,Poland,Spain,United Kingdom,Malta,Italy,Switzerland,France
Call: Development of mined, lined rock cavern for gaseous hydrogen storage (HORIZON-JU-CLEANH2-2025, 2025)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 5546727.04
EU funding (EUR): 4999995.58
Participants: 15
Project status: SIGNED

Large-scale underground hydrogen storage (UHS) is emerging as a key enabler for balancing renewable energy supply and demand. Yet many regions lack the suitable geology needed for conventional UHS. HyCavern responds to this gap by developing cost-effective, safe, and standardized solutions for H2 storage in mined, lined rock caverns (LRC). By tackling key technical, economic, and geological challenges, HyCavern unlocks scalable hydrogen infrastructure in areas previously considered unsuitable and increase the lifespan of storage caverns. The project will: - Mitigate cyclic load- and hydrogen-specific risks - such as embrittlement, fatigue, and leakage - through advanced material innovations (steel, concrete) and predictive modeling for long-term performance. - Automate cavern construction and maintenance with a mobile robotic system that combines laser welding and coating, reducing personnel costs, increasing safety, and enabling in-situ repairs. - Adapt cavern designs to diverse European lithologies by integrating geomechanical/geochemical experiments, large-scale validations, and advanced simulations. - Implement conformance-based monitoring tools to detect early deviations from safe operational parameters and support proactive risk management. - Quantify economic value across storage use cases through comprehensive techno-economic analysis, highlighting key requirements for the technology’s competitiveness and identifying cost drivers. - Conduct techno-economic analyses across diverse storage use cases to quantify the economic benefits for each application while identifying key requirements for the technology’s competitiveness. - Deliver a practical, replicable guideline tool to assist Storage System Operators (SSOs) in fast-tracking preliminary feasibility assessments and identifying LRC potential across Europe. By reducing storage costs and enhancing energy security, HyCavern directly supports Europe’s transition to a resilient, decarbonized energy system.

Keywords: lined rock caverns hydrogen storage material innovation
Rethinking the Efficiency-Redistribution Trade-Off: Taxes, Transfers, and Household Inequality (RETTHINQ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1320991.88
EU funding (EUR): 1320991.88
Participants: 1
Project status: SIGNED

Income and wealth inequality have surged in OECD economies over recent decades, sparking renewed debates on the optimal tax-and-transfer system. How should governments design redistribution to the poor? Which taxes should be used to finance the safety net? This proposal consists of three projects combining rich quantitative models with analytical and empirical insights to push the frontier on our understanding of the efficiency-redistribution trade-off. Part I explores how to design income support to the poor. Since the 1980s, many OECD economies have reformed their safety net and introduced work requirements for several welfare programs. Work requirements foster efficiency as they incentivize labor supply but limit redistribution to the poorest. We document the shift in the distribution of transfers across households in the United States since the 1980s and quantify the optimal balance between standard means-tested transfers and those conditional on work requirements. Part II explores how to adjust consumption taxes in recessions. Consumption taxes make up a large share of fiscal revenue in OECD economies, yet their regressive nature raises distributional concerns. Temporary consumption tax cuts have been recently proposed to fight recessions, with the joint goal of easing the burden on the poor and stabilizing the economy. We theoretically and quantitatively analyze the stabilization properties of temporary consumption tax cuts. Part III explores how to raise revenues from the wealthy. Capital income taxes have been regularly proposed to finance redistribution, with no consensus on their efficiency cost. High capital income likely reflects skills of investors selecting productive private businesses, but it may also stem from the market power of wealthy investors. We examine the nature of high returns of investments in private businesses of the wealthy in Norway, and quantify their implications for the optimal level of capital taxes.

Keywords: macro public finance,heterogeneous agents,inequality,taxation,redistribution,labor supply,automatic stabilizers,capital returns
RespOnSiblE Time and Tech in an Accelerated Digitised World (ROSETTA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland,Norway,France,Sweden,United States,Greece,Germany,United Kingdom
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1814880.0
EU funding (EUR): 1814880.0
Participants: 21
Project status: SIGNED

The ROSETTA programme proposes a transformative agenda to examining the impact of technology in an increasingly accelerated, high pressured world. ROSETTA will provide 19 recruited fellows with the highest quality research environment and a training programme that ensures their ability to provide leadership in the sectors relevant to design evaluation and regulation of technology from a time perspective. ROSETTA will be coordinated by the University of Galway Ireland (main beneficiary) through Lero, Science Foundation Ireland Research Centre for Software and involves 4 other Irish universities: University College Cork, University of Limerick, University College Dublin, Trinity College Dublin. Fellows will complete a compulsory secondment at one of 20 Associated Partners. Fellows will be recruited from the fields of computer science, medicine, biomedical engineering, education, psychology, software engineering, information systems, human-computer interaction and business management. Fellows will choose their own research topic within one or more the ROSETTA themes, adding to the truly interdisciplinary nature of the programme. ROSETTA will incorporate international mobility, intersectoral exposure, and interdisciplinarity. Fellows will receive training on the latest, emerging time theories, methods, and equipment through five Summer/Winter schools. Fellows will be provided with a comprehensive set of courses to improve their transferrable skills to diversify their employment options. Fellows will have access to Lero supports such as workshops and seminars, industry collaboration, public engagement, and communications. Fellows will be uniquely positioned to design and evaluate technology, and policies and legislation on technology use with new expertise and perspectives on how technology affects our time. The total budget required to deliver ROSETTA is €3.5M. We request €1.8M from the European Commission to be matched by €1.7M from Lero and the main beneficiary.

Keywords: time,acceleration,digital transformation,health and wellbeing,productivity
Developing Intercropping for agrifood Value chains and Ecosystem Services delivery in Europe and Southern countries (IntercropValuES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: France,Spain,Netherlands,Germany,Italy,Mozambique,Greece,Belgium,Sweden,Denmark,Austria,Serbia,China,Switzerland,United Kingdom
Call: Intercropping – understanding and using the benefits of complexity in farming and value chains (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 7419463.75
EU funding (EUR): 7419463.75
Participants: 28
Project status: SIGNED

IntercropValueES aims to exploit benefits of intercropping to design and manage productive, diversified, resilient, profitable, environmentally friendly cropping systems acceptable to farmers and actors in the agri-food chain. It will develop both a scientific research action for better understanding and modelling intimate intercrop functioning and a detailed analysis of lock-ins and levers at the value chain level to identify credible solutions that can be adopted by farmers and value chain actors. As a multi-disciplinary and multi-actor project, it brings together scientists and local actors representing food value chain. It includes 27 participants from 15 countries (3 continents) from a wide diversity of organizations and stakeholders. IntercropValuES organizes its activities in 6 objectives, to: 1) support the design of locally relevant, legitimate and innovative agri-food chains, through 13 Co-Innovation Case Studies; 2) understand the functioning and G*G*E*M interactions allowing the selection of compatible ideotypes and the optimization of machinery and management strategies for maximizing the productivity and delivery of ecosystem services with better soil health and mitigation of GHG (meta experiment 15 sites); 3) produce novel information, improved methods and tools for intercrop management and the assessment of their performance and profitability; 4) unravel intercropping performance by modelling; 5) analyze grain and sanitary quality of cereal-legume intercrops, functional qualities for food processing and new products, 6) uncover key barriers and levers at the value chain level to boost development, and identify new market avenues and solutions to increase economic added-value of intercrops. The Comms and Dissemination Plan is designed to diffuse outcomes widely by adapted channels to different end-users, such as farmers, advisors, food processing companies and machinery industries, retailers and citizens, academia, policymakers and influence bodies.

Keywords: intercropping biodiversity agroecology ecosystem services soil health ghg sustainable farming food quality multi actor participatory research intercrop models field experiments management
Characterization and engineering of non-heme iron-dependent Rieske oxygenases involved in cyanobacterial indole alkaloid biosynthesis (CyBRiOx)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 272536.32
EU funding (EUR): 272536.32
Participants: 2
Project status: SIGNED

Enzyme catalysis is a key technology at the heart of industrial biotechnology, which is expected to drive economic growth and industrial leadership in the EU, while effectively addressing social, environmental and economic needs. Despite the growing impact of biocatalysis, the full potential of this technology has yet to be realized. Major current limitations are: i) only a limited number of chemical reactions are amenable to biocatalysis, and ii) the unique enzymology encoded in the genome of organisms has been minimally explored. CyBRiOx will address this gap by elucidating the role of Rieske oxygenases (RiOx) in the late diversification pathway of indole alkaloids, a fascinating group of compounds with promising biological activities. In doing so, CyBRiOx will not only decipher the complete biosynthesis of these promising drug targets, but in parallel will develop novel RiOx biocatalysts catalyzing much-underdeveloped reaction classes in biocatalysis, namely CoA-independent desaturations and oxidative C-C bond formation reactions. This will be achieved by integrating knowledge of the natural activity of enzymes with bioinformatics, structural biology, enzyme engineering and organic synthesis to develop novel biocatalysts for highly underdeveloped reaction classes. Expanding the scope of existing RiOx offers tremendous potential for a cleaner, more selective, more efficient and therefore cheaper route to various key structural motifs relevant to the industrial and pharmaceutical industries. CyBRiOx will achieve this through the collaboration of the postdoctoral fellow with two leading experts in the field. The MSCA grant will allow the research fellow to further develop his scientific and transferable skills, expand his network, and enhance his overall career prospects and employability to become one of the next generation of leading scientists.

Keywords: biocatalysis,biotechnology,enzymology,catalysis,rieske oxygenase,indole alkaloids
European Framework for Advanced Medical Technology Evaluation and Follow-up (EU4MEDTECH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Croatia,Germany,Finland,Ireland,Portugal,Spain,Slovakia,Hungary,Norway,Greece
Call: Developing EU methodological frameworks for clinical/performance evaluation and post-market clinical/performance follow-up of medical devices and in vitro diagnostic medical devices (IVDs) (HORIZON-HLTH-2024-IND-06, 2024)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 7676743.75
EU funding (EUR): 7676743.75
Participants: 14
Project status: SIGNED

The Medical Devices Regulation (MDR) and In Vitro Diagnostic Medical Devices Regulation (IVDR) have been introduced, replacing previous MD and IVD Directives to strengthen the EU regulatory framework, ensuring the highest levels of patient safety and smooth functioning of the single market for these products. Yet, this regulatory update comes with challenges arising from the increased regulatory burden and strain across various actors in the EU HealthTech value chain. To overcome these hurdles, in EU4MEDTECH, we will co-create (with an a-priori established Stakeholder Forum) and validate “EU4MEDTECH framework”, a versatile and life cycle-oriented set of methodological approaches, standardised models, and multi-domain criteria for the generation and evaluation of clinical and performance evidence of high-risk, innovative MDs and IVDs across pre-/post-market stages. An interactive, cloud-based digital platform will be designed and developed to operationalise EU4MEDTECH framework. The latter will include further features, such as a regulatory communication channel, a global regulatory search feature, a user training feature for EUDAMED stakeholders and a repository. EU4MEDTECH framework and recommendations for new common specifications, once integrated into the digital platform, will be evaluated within 3 different Use Cases (UCs). UC1 will focus on class III and implantable MDs, UC2 will target class C/D IVDs, whereas UC3 will focus on MD and IVD software (MDSW/IVDSW) and other highly innovative devices. 3 clinical studies will be performed in the context of UC3. Similarly, the digital platform will be evaluated through a Proof-of-Concept (PoC) study. Key MedTech stakeholders will be engaged in co-design throughout the project activities. A comprehensive exploitation roadmap will be developed to ensure that project results are widely and equitably adopted, scalable, and sustainable.

Keywords: medical devices in vitro diagnostic medical devices medical device regulation in vitro diagnostic regulation health technology assessment
Decoding multimodal TBI markers for optimized recovery (NeuroVitalizer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499587.5
EU funding (EUR): 1499587.0
Participants: 2
Project status: SIGNED

Traumatic brain injury (TBI) occurs when mechanical forces shake the brain and disrupt normal brain function, affecting biological processes like cellular, molecular, and electrical functions. These processes are highly interconnected, making it difficult to fully understand TBI recovery with traditional single-discipline methods. Current approaches often fail to address the complexity of TBI even in mild to moderate cases, creating an urgent need for new methods to overcome existing limits in data collection, integration, and interpretation across multiple subdisciplines. In this project, I will set up a new framework for a comprehensive and systematic analysis of recovery processes post-trauma and the effect of electrical stimulation (ES) in in vitro models for mild to moderate TBI, which allows for a detailed examination in a controlled environment. Our experimental workflow will integrate insights on cellular morphology and structure from microscopy images, electrical activity, and network synchronization from multi-electrode array recordings, protein expression changes from immunostaining, and cell viability and stress markers found in the cell medium. Calcium imaging will provide insights into ionic homeostasis maintenance. An AI-driven data fusion approach will facilitate the analysis of these multimodal datasets revealing hidden patterns and relationships that traditional approaches cannot uncover. Specifically, we want to address questions such as • How do astrocyte protein expression and neuronal electrical activity relate to repair after TBI? • To what extent can ES prevent neuronal death, and what are the best stimulation protocols? When should we start the treatment? • Are there early biomarkers that can predict recovery success or delays? This project introduces a cutting-edge method by integrating a multimodal data fusion setup and AI-based synthesis to tackle TBI recovery from multiple angles, capturing the complexity that standard approaches miss.