Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The molecular nexus coupling Cell Metabolism to Cell cycle and Genome Surveillance (META-SURVEILLANCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1499329.0
EU funding (EUR): 1499329.0
Participants: 1
Project status: SIGNED

Metabolic fluctuations and changes in DNA replication and cell cycle dynamics orchestrate early development and tumorigenesis. Of particular interest are reactive oxygen species (ROS), by-products of basal metabolic reactions, and major signaling molecules driving cell proliferation, differentiation, and cancer cell growth. However, despite their utmost importance in cell physiology, how ROS signals communicate to the cell cycle and genome safeguard mechanisms remains poorly explored. My postdoctoral work has illuminated this topic by discovering novel redox-sensitive mechanisms that directly couple metabolic nucleotide fluctuations and oxygen starvation to DNA replication dynamics. These findings revealed that ROS-signaling could operate as a prime and cell cycle checkpoint-independent surveillance for replicating genomes. Since profound alterations in metabolic pathways and redox state naturally entail embryonic growth, cell differentiation, and cancer transformation, in such scenarios, can metabolic cues in the form of ROS align cell cycle states and DNA replication? In this application, I propose to address this question by dissecting the mechanisms that align core cell cycle machinery and replisome dynamics to endogenous ROS fluctuation in tailor-made cellular models of early mammalian development (stem cells) and cancer. By combining innovative analytical tools, including CRISPR-based tagging of endogenous proteins with biochemistry and advanced cell biology (e.g., quantitative single-cell imaging of redox-state, Cyclin-CDKs, and genome caretakers; replication fork sequencing), I will define the molecular nexus coupling metabolism with genome surveillance at the global (genome-wide) and local (replisome) level. These investigations will provide an unmatched picture of regulatory foundations of cellular and genome integrity in normal and pathophysiological contexts, enhancing understanding of genome surveillance in development mechanisms and disease.

Keywords: dna replication,cycle cycle,cycle cycle checkpoint,replication stress,genome protection,metabolic signaling,redox homeostasis,early development,cancer,quantitative imaging
SUSTAINABLE MULTI-FUNCTIONAL AND RECYCLABLE HEAT PUMPS (Smart-Pumps)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Greece,Denmark,Spain,Italy
Call: Innovative components and configurations for heat pumps (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1999952.5
EU funding (EUR): 1999952.5
Participants: 6
Project status: SIGNED

Smart-Pumps aims (1) to optimally redesign heat pump components under the newly introduced Design for Additive/Hybrid Manufacturing concept, which apart from operational characteristics, includes all life-cycle parameters, such as recycled material sourcing and component recyclability, for maximum efficiency, sustainability, safety and reliability, (2) to utilize multiple materials which are mixed at different percentages in the various operational sections of heat pump components, following the Functional Grading methodology, thus fully exploiting their properties (mechanical, thermal, electrical, etc) and maximizing material usage efficiency, (3) to embed sensors and devices within heat pump components for monitoring and operational data extraction, and also for actively changing heat pump component structure to optimize operation, (4) to standardize testing and create manufacturing process and assembly protocols, and (5) to create training curricula for all relevant stakeholder on digital design, manufacturing and testing of Smart Heat Pumps.

Keywords: heat pump,additive manufacturing,embedded sensors,efficiency,sustainability,performance,training and certification
Entanglement as a tool in holography and quantum simulators (ETHOQS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

Quantum entanglement plays a pivotal role in various interconnected fields ranging from quantum information, simulation, black hole physics to condensed matter physics, among others. This proposal aims at studies of novel models and observables which strengthen the connection between quantum many-body and holographic systems through the lens of entanglement. In first part of the proposal the expertise of the Host in quantum quenches in presence of symmetries is used to extend interesting questions in simple holographic models, which are expertise of the Applicant. The second part of the proposal plans to explore theoretical and experimental signatures of holography using many-body models realizable in present day quantum simulators. The goal of the action will be supported by a secondment in one of the leading institute for quantum information and simulations.

Keywords: entanglement in many body quantum systems,holography ads cft correspondence,quantum simulations,syk model
Mechanosensitive proteins as a pathway to mechano-targeted drug delivery (ForceDelivery)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

Biophysical research over the last two decades has revealed that an impressive number of mechanical signals are key regulators of cell behavior. So far, the focus has been on understanding fundamental mechanosensing and transduction mechanisms in health and disease. As increasing numbers of molecular players and signalling pathways are identified, the time has come to utilize this knowledge for diagnosing and treating diseases where mechanical processes play a role. In this proposal, I aim to target integrins to deliver reporter molecules and drugs to cells with a distinct mechanical phenotype. Integrins are transmembrane receptors through which cells can sense, transmit and discriminate biomechanical forces. During cell adhesion and migration, integrins engage with specific ligands in the extracellular matrix and undergo integrin recycling through continuous endo- and exocytosis. This known endocytic pathway, integrin clustering during adhesion and overexpression in disease states has made integrins a prime target for drug delivery. However, the chemical and physical factors governing integrin-mediated uptake of drugs and their intracellular fate are unknown. I propose to utilize molecular force sensor (MFS) technology to deconvolute the key factors in integrin-mediated drug delivery. Using rational protein design, a series of coiled coil MFSs with distinct chemical (charge and hydrophobicity) and physical (mechanical and thermal stability) properties will be produced. The molecular constructs will be appended with the integrin-targeting RGD motif, a fluorescent protein to investigate the intracellular fate and an actin-binding protein as a model drug that may potentially interfere with the cytoskeleton architecture. This MFS-based drug delivery system will enlighten the pivotal factors of integrin-mediated delivery, provide a diagnostic assay for discriminating cells based on their mechanical phenotype and open up the road towards mechano-targeted drug delivery.

Keywords: mechanobiology,drug delivery,mechano targeting,fusion protein,integrins,molecular force sensor,coiled coil,biomolecular design,fluorescence
Metaplastic Spintronics Synapses (METASPIN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Italy,Germany,Czechia,Switzerland
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 2999750.0
EU funding (EUR): 2999750.0
Participants: 9
Project status: SIGNED

In METASPIN we envision a radically new low-power artificial synapse technology based on spintronics nanodevices that will prevent catastrophic forgetting, i.e. the loss of memory of previously learned tasks upon learning new ones, a major flaw currently faced by all artificial intelligence applications. We will develop a new class of neuromorphic hardware that will use magneto-ionics to support synaptic metaplasticity, i.e. a feature inspired by the human brain based on assigning a ‘hidden value’ to the states of artificial synapses to encode how important each state is. This will make it easier or harder to reconfigure the synaptic state upon learning a new task, giving a hierarchy to previously learned information and thus preventing catastrophic forgetting. The synaptic states will be given by the two magnetisation orientations in ferromagnets with perpendicular magnetic anisotropy, and by ferro/antiferromagnetic order in materials where the two phases coexist. In all cases, magneto-ionic gating will be used to locally modulate intrinsic magnetic properties to assign ‘hidden states’ to each synaptic state. The magneto-ionic hidden states will translate into a modulation of the switching probability between synaptic states, introducing the metaplasticity functionality. In parallel, we will develop ANNs learning schemes, adapted to our device physics and inspired by biological synaptic activity, that can learn with mitigated catastrophic forgetting. The ultimate goal of this project is to integrate this advanced synaptic technology and learning algorithms into an ANN demonstrator to test multitask learning on proof-of-concept tasks inspired by medical AI, and assess the impact of metaplasticity in catastrophic forgetting.

Keywords: artificial synapse,magneto ionics,artificial neural network,binarised neural network,spintronics,metaplasticity
The coming of age of a new legal discipline: developing the general doctrine of energy law (INTEL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

INTEL makes a ground-breaking contribution to energy law scholarship by developing the general doctrine of energy law in a European context. While all well-established legal disciplines have an understanding of their doctrine, energy law does not. A general doctrine consolidates the foundations of a discipline and guides legislators, courts and lawyers in identifying, valuing and interpreting legal norms. In light of the energy transition and the energy crisis in Europe, it is imperative to solidify and cohere the foundations of energy law. INTEL will mark a breakthrough moment in energy law scholarship by putting forward a general doctrine for the field. This outcome will require constructing and analysing the concepts and principles that drive the field and abstracting its theoretical underpinnings from these analyses. INTEL is designed around five transversal Research Questions (RQs) that each unravel layers in the development of the doctrine. Together, the RQs explore the evolution of energy law (RQ1), the concepts and principles emerging from legal sources (RQ2) and the theories underpinning them (RQ3), the way in which legal professionals perceive doctrine (RQ4) and how doctrine can be authenticated by the broader energy law community (RQ5). The exploration of these RQs relies on a mixed methods approach, with each method implemented in its own Work Package (WP). These combine natural language processing and temporal network analysis (WP1), doctrinal legal research and jurisprudence (WP2), co-creation with the community of energy law scholars (WP3) and dialogue-driven expert interviews analysed through grounded theory (WP4). INTEL will advance the field of energy law by bringing coherence and predictability to the legal system governing energy, affording an understanding of the capacity of energy law to govern societal changes and advancing methodological diversity in legal research by creating a novel technique for constructing a general doctrine.

Keywords: energy law,natural resources law,european union law
SUstaiNable inteRventions and healthy behavIours for adoleScent primary prEvention of cancer with digital tools (SUNRISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Greece,Portugal,Spain,Italy,Belgium,Romania,Switzerland,Australia,Cyprus,Slovenia,Estonia
Call: Enhance primary cancer prevention through sustainable behavioural change (HORIZON-MISS-2023-CANCER-01, 2023)
Start date: 2024-01-01
End date: 2028-04-30
Duration (months): 52.0
Total project cost (EUR): 5998408.75
EU funding (EUR): 5998311.75
Participants: 19
Project status: SIGNED

Primary prevention of cancer through behaviour changes in adolescence – a critical period in which many risk behaviours are initiated –, is a huge health and societal challenge in Europe. In alignment with this need, SUNRISE will co-create, implement and evaluate an innovative digitally-enhanced life-skills programme for primary prevention of cancer through sustainable health behaviour change in adolescents, tailored to their socio-economic, cultural and environmental diversities. SUNRISE will combine an established, evidence-based digital solution for smoking prevention, with novel intervention approaches such as peer social media campaigns, advertising literacy training, educational games, and social robot platforms, to take cancer prevention approaches for adolescents in the EU to the next level. The digitally-enhanced programme and its components will be developed through co-creation with schools-as-living-labs methods involving multiple societal actors such as educators, adolescents, parents, public health experts, and policy-makers. The programme will be implemented and evaluated at large scale across 154 schools and 7500 students in urban and rural regions of 8 European countries - Greece, Switzerland, Slovenia, Spain, Cyprus, Italy, Belgium, Romania -, including socially disadvantaged groups such as migrants and ethnic minorities. The effectiveness of both methods for achieving long-term health behaviour change, as well as the implementation strategy for solution adoption and multi-country sustainability, will be evaluated. This action is part of the Cancer Mission cluster of projects on “Prevention & early detection (behavioural change).
Performance Optimisation and Productivity 3 (POP3)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Spain,Germany,Czechia,Portugal,France
Call: Call on Centres Of Excellence For Exascale HPC Applications (HORIZON-EUROHPC-JU-2023-COE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 5996896.25
EU funding (EUR): 2998448.13
Participants: 8
Project status: SIGNED

The key element to ensure efficient use of HPC infrastructures is to optimize the performance and efficiency of the applications. The Centre of Excellence on Performance Optimization and Productivity (POP CoE, www.pop-coe.eu) was initiated in October 2015 with the fundamental purpose of assisting a broad community of HPC application developers and users in both science and industry domains helping them to understand the performance-related issues of their applications and thus improve their efficiency and productivity. This fundamental purpose is reached by externally and objectively auditing the performance of the codes to all interested users, by providing not only qualitative but also quantitative analysis through the use of POP tools and methodology. The current proposal, Performance Optimization and Productivity 3 (POP3), is articulated in 3 main pillars: services, users, and co-design. POP services mainly focus on performance assessments with the goal to evaluate code performance and scaling, identifying the main sources of inefficiency and providing some insight and recommendation about how to improve it. POP3 also provides second level services that have been extended and include proof of concepts, energy efficiency and advisory studies. Although POP3 will continue targeting all scales and types of users, with this proposal we will focus our efforts on larger scales, assessing the execution on the EuroHPC sites of some of the European flagship HPC applications for other CoEs. However, POP3 will still provide services to prescribers and SMEs to promote an efficient usage of the computing resources. The co-design will be covered in two dimensions. Internally in POP3 we will co-design the tools and methodology to be able to analyse the applications on the selected platform at the selected scale. Externally, POP3 will identify best practices and kernels that will be offered to other European projects as well as the wide audience of parallel applications.

Keywords: performance tools and analysis,code optimization,parallel programming models,productivity,metrics and methodology
Empire of solidarities: a connected history of private charity across a decentred Romanov Empire, 1855–1914 (EMPSOLID)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Estonia
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499954.0
EU funding (EUR): 1499954.0
Participants: 1
Project status: SIGNED

By the late nineteenth century, the Romanov Empire stretched half-way across the globe, turning inhabitants of the territory stretching from today’s Tallinn to Vladivostok into subjects of one and the same empire. Yet, we know little about whether the population felt any impulse to help one another in times of need. Under what circumstances did people feel compassion towards distant others and how far-ranging did their sympathies extend? What did these solidarities mean, how were they enacted and expressed through ideas, emotions, and lived experiences? If solidarities could reach across such a multiconfessionally and multiethnically heterogenous empire, how does the Romanov experience enrich our understanding of empire and solidarity as seemingly irreconcilable notions? EMPSOLID applies an unconventional lens to answer these questions. It pioneers a new history of affective practices that, for the first time, focuses on private charity as a method to make solidarities visible and allow us to study them in action. The project’s objectives are to: 1) trace the conceptual history of solidarity in the empire; 2) gather and analyse examples of grassroots private charitable initiatives (benevolent and charitable associations, fundraising campaigns, and private donations) across four regionally distinct Romanov imperial border regions (Baltic provinces, Southwestern provinces, South Caucasus, Turkestan) from 1855-1914 on behalf of beneficiaries outside of the givers’ vicinities; and 3) digitally map flows and networks of donations to generate insights into larger trends and spatial patterns in charitable practices. The project’s ambitious, decentring perspective aspires to envision a long-overdue new spatial history of the Romanov Empire in the long nineteenth century founded on horizontal threads of solidarity linking regions and postulates that these charitable entanglements formed a crucial part of the social fabric holding together nineteenth-century empires.

Keywords: charity