Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Breaking barriers: Investigating the junctional and mechanobiological changes underlying the ability of Drosophila immune cells to invade an epithelium. (BB: DICJI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 179137.2
EU funding (EUR): 179137.2
Participants: 1
Project status: CLOSED

The ability of cells to invade underlies many pathological conditions such as metastasis and inflammation. Invasion requires coordination of changes in the biology of the invading cell coupled with changes in the adhesive behavior and integrity of the penetrated barrier. This proposed project aims to understand the modulation of epithelial integrity during immune cell transmigration. Recent work has shown that Drosophila hemocytes invade through an epithelial barrier during embryonic development and require the small GTPase RhoL to breach Cadherin barriers. We will identify morphological and biophysical changes in epithelial integrity during this immune cell transmigration. To assess potential changes in junctional Cadherin expression during hemocyte invasion, immunofluorescence analysis and live imaging of junctional DE-Cadherin and the Actomyosin network will be performed. This will be followed by “Fluorescence Recovery after Photobleaching” (FRAP) studies of DE-Cadherin-GFP fusion proteins to understand whether hemocyte invasion alters DE-Cadherin stability at the junctions. These experiments will provide clear insight into whether changes in DE-Cadherin integrity precede hemocyte invasion. Cell-cell junctions are known sites of mechanotransduction and hence this project will next aim to evaluate possible changes in the mechanobiology of Adherens junctions during transmigration. A FRET based tension sensor will be cloned into Drosophila and utilized to assess if there is force generation at the Adherens junctions during transmigration. This will be followed by laser nanoablation of cell junctions to assess changes in cortical tension during hemocyte invasion. These studies will concertedly address the role of junctional changes and mechanotransduction during invasion and thus provide new insight into epithelial biology during immune cell transmigration. Our studies should have relevance for future studies of pathologies like inflammation and cancer metastasis.

Keywords: drosophila,immune cells,adhesion,invasion,cadherin,frap,fret,mechanobiology
Circulating modernity: the role of student missions sent to Europe in the scientific and social modernization of pre-colonial Morocco (1873-1912) (EUROMOROCCANSCIENCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The proposed project will analyze the scientific and social modernization of pre-colonial Morocco resulting from the circulation of young medical, scientific and engineering students in Europe in the period 1873-1912. This general aim will be achieved by: I. Mapping the identity, family background, social extraction and previous education of Moroccan students; II. Determining the actual scientific education and training they received in various European host institutions. III. Determining the context and actual impact of their re-insertion in Morocco. IV. Establishing the contribution of European-trained scientists to Moroccan nationalist and anti-colonialist movements. Four case-studies will be considered, corresponding to student missions sent by the Moroccan government to institutions of Great Britain, France, Spain and Italy. Methodologically, this project is strongly interdisciplinary, combining approaches from the history of science, history of education, colonial history and modernization theory. It follows a tradition of prosopographic studies, though further develops it through a circulation perspective. It also breaks the scholarly tendency to work exclusively on idealized knowledge by focusing on person-oriented and practice-oriented research. Finally, it intends to promote a greater internationalism by analyzing and comparing several national settings. The project's relevance stems from its being a strong historical example able to inform reflection on the design of current European cooperation policies in science & technology development and democratization in Mediterranean partern countries. It will also raise public awareness on the long-running importance and impact of European scientific expertise in the world. Lastly, it will be in tune with current challenges in the field of history of science: the need of understanding scientific research and practice in a circulatory and global perspective

Keywords: s115 history of science and technology,s406 colonial history - entangled histories - global history,s213 education,s107 transformation of societies - democratization - social movements
Secure Personal Data Services for Efficient Home Energy Management (PDS4NRJ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-08-01
End date: 2014-07-31
Duration (months): 12.0
Total project cost (EUR): 134871.9
EU funding (EUR): 134871.9
Participants: 1
Project status: CLOSED

With the convergence of mobile communications, sensors and online social networks technologies, we are witnessing a dramatic increase in the creation and consumption of personal data. Such data is volunteered by users, automatically captured by sensors or inferred from existing data. They represent an unprecedented potential for applications and business. This is especially true for the energy system, where smart meters and home automation systems promise to deliver significant savings on the path to a low carbon society. Until now, the enthusiasm for new opportunities has thwarted privacy concerns. Nevertheless, the risk of a backlash is growing as new devices and new services bring us closer to the dystopias described in science fiction literature. The key challenge is to improve the control that users have over their personal data. More specifically, as the World Economic Forum pointed out, there is a need for a data platform that allows users to share their personal data – specially their home energy consumption data -- while retaining some form of control over who accesses this data (access control) and more importantly how it is used (usage control). This project, called PDS4NRJ, is based on the insights that (a) secure personal data management can be radically improved with the advent of secure hardware embedded on personal devices at the edges of the Internet, and (b) that a secure personal data management infrastructure should be applied in the context of smart buildings. Our overall objective is to define a new form of decentralized infrastructure for sharing smart meter data with access and usage control guarantees. The PDS4NRJ project is a unique opportunity for Philippe Bonnet, currently associate professor at ITU (Denmark), to become a leading expert in the field of secure personal data management under the supervision of Prof. Pucheral from INRIA (France).

Keywords: personal data,secure data management,smart meter.
UNDERSTANDING THE IMPACT OF SEASONALITY IN TERRESTRIAL BIO-GEOSYSTEMS DURING THE LAST 23 MILLION YEARS (SEASONS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 168794.4
EU funding (EUR): 168794.4
Participants: 1
Project status: CLOSED

The proposed project aims to investigate and understand the development of seasonality in terrestrial ecosystems of Northern Hemisphere during the last 23 million years, which caused massive ecosystem transformations, such as the spread of grasslands over large fractions of the globe. The project will concentrate on giving the researcher, Jussi T. Eronen, training in vegetation modelling and understanding of isotope analysis to enable him to work fluently within both modeling and proxy data communities. There are two main components that constitute this project: Global-scale vegetation modelling (first objective), and synthesis of vegetation modelling with fossil and isotopic paleoenvironmental data (second objective). Main research tools are dynamic vegetation modelling, fossil data, and isotope records. The project innovatively uses the fossil data to derive proxy estimates of the key environmental variables such as Net Primary Production, temperature, precipitation and seasonality. The original approach in this project is to merge vegetation modelling seamlessly with fossil data and stable isotope records to synthesize available information. Aim is to gain insight into interactions of biotic and abiotic systems on long (geological) timescales. As a result, we can investigate the biological dynamics of pre-Quaternary times at a global scale and identify critical transitions and thresholds in the past. This project increases our understanding of the processes by which terrestrial ecosystems respond to increased seasonal variations of climate. It is directly related to one of the major societal challenges in the Mediterranean region, the projected impact of current climate change on heat waves, and increased rainfall seasonality. This project establishes Eronen as one of very few people in the palaeo-community who can work with actual fossil data, derive variables based on fossil data as well as design modelling scenarios based on fossil data and perform modelling.

Keywords: v201 paleoclimatology - paleoecology,v303 biogeography,v201 climatology and climate change,v201 sedimentology - soil science - palaeontology - earth evolution
zebrafish model to study human hypertension (NOVEL KIDNEY MODEL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-10-23
End date: 2014-10-22
Duration (months): 12.0
Total project cost (EUR): 111889.2
EU funding (EUR): 111889.2
Participants: 1
Project status: CLOSED

Kidney dysfunction is central to hypertension. Mutations in the WNK/SPAK-OSR1 pathway cause human hypertension by modulating salt transport. Yet, just when the physiological actions of these proteins appear clear, contradictory data raise questions about their effects, and leave investigators confused about physiological roles and mechanisms of disease. Here, we propose to develop a novel zebrafish model system to permit us to study how NaCl transport is regulated. Our groups have used variety of approaches to study the thiazide-sensitive Na-Cl cotransporter (NCC) over time. We have, however, been frustrated by the inability to study mechanisms of transporter regulation in situ. Organismal solutions to problems of terrestrial life, however, often evolved from challenges encountered during aquatic life. Fish electrolyte homeostasis is maintained, therefore, by a panoply of proteins that are conserved. Fish kidney develops first as pronephros with tubules homologous to nearly every mammalian nephron segment. Studying the pronephros offers excellent experimental conditions throughout. Here, we propose to utilize the unique morphological resources available through the Bachmann group to develop a zebrafish model to study salt transport regulation. We plan to use the simple organization of the pronephros to establish a three dimensional model of the signaling proteins involved in regulating NCC activity. Work will be organized in collaboration with zebrafish specialists at the Max Delbrück Centrum (MDC) in Berlin. Specifically, we will, 1. Analyze zebrafish NCC and NCC-like 2 expression, localization, phosphorylation, and activity 2. Determine effects of NCC and NCC-like 2 knockdown 3. Determine effects of WNK4 and OSR1 knockdown on NCC and NCC-like 2 4. Determine how distinct ion loads affects the NCC signaling complex. The transfer of knowledge in hypertension research to the European host and to European collaboration partners, will be central to this project.

Keywords: hypertension,kidney,l307 cell signalling and cellular interactions,l302 cell biology and molecular transport mechanisms,l301 morphology and functional imaging of cells,l401 organ physiology
The dendritic cell receptor DNGR-1: Modulation of endosomal dynamics upon recognition of necrotic cells (DNGR-1 IN DCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 2
Project status: CLOSED

Dendritic cells (DCs) play an essential function in initiating adaptive immunity. Key to DC function are receptors for recognizing and capturing pathogens and damaged cells and for controlling subsequent antigen extraction, processing and presentation. DNGR-1 (also known as CLEC9A) is a DC-restricted C-type lectin receptor (CLR) that recognizes the actin cytoskeleton exposed on necrotic cells. DNGR-1 is not required for internalization of cell corpses by DCs but regulates their subsequent ability to crosspresent corpse-associated antigens to CD8+ T-cells. The mechanisms underlying DNGR-1 function are unknown but require receptor signaling upon ligand engagement and are though to relate to modulation of endocytic traffic. Here, I hypothesize DNGR-1 promotes the stabilization of a non-degradative endo-/phagosomal compartment containing dead-cell associated cargo to permit antigen extraction from cell corpses and subsequent crosspresentation. I propose to address this hypothesis by investigating the intracellular trafficking of DNGR-1 and its ligand and the role of DNGR-1 on the endo-/phagosomal environment in DCs.

Keywords: dendritic cells,innate immunity,pattern recognition receptors,c-type lectin receptors,crosspresentation,phagocytosis,membrane trafficking,endosome,phagosome
Effects of early programming on child's neurodevelopmental outcomes (NUTRIOMICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-15
End date: 2016-04-23
Duration (months): 24.0
Total project cost (EUR): 230036.6
EU funding (EUR): 230036.6
Participants: 1
Project status: CLOSED

Diet plays an important role on the effects of neurodevelopment and there is evidence that early nutrition can influence later neurodevelopmental outcomes. Folate and polyunsaturated fatty acids, nutrients obtained via diet, are considered of extreme importance for neurodevelopment. However, the current knowledge on this field is largely based on animal, retrospective, short-term nutritional intervention studies in humans, and the scarce randomised control studies performed in humans provide controversial results. A multi-centre well-designed project of the long-term effects of early nutrition on child’s health is needed. Another important factor in child’s development is the effect of maternal metabolic pathologies, particularly obesity, on child’s early programming. Obese women are frequently deficient in fatty acids and folates during pregnancy, nevertheless there are only few studies on maternal BMI and its effects on nutrional status. It is not known to what extent BMI influences early programming. The current project aims to study the short and long-term effects of early programming (maternal supplementation during pregnancy and maternal obesity) together with polymorphisms in fatty acid and folate metabolism on maternal metabolomics during pregnancy and infant’s transcriptomic and epigenomic profiles at delivery in association with child’s neurodevelopmental outcomes. The current project would enable to establish positive dietary and body weight recommendations for women planning pregnancy and for pregnant women, which could be of broad social significance in terms of affecting health behaviours, education, work potential and mental illness in every age group. Further, the general concept that early programming might program long-term health has potentially far-reaching consequences. Additionally, the systems biology approach of integrating genetic, transcriptomic, epigenomic, and metabolomic information would provide more complete picture of living organism.

Keywords: folate,fatty acids,omics,neurodevelopment,polymorphisms
Plant Cell Wall Dynamics During Cell Cycle (CEWALDYN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 221154.6
EU funding (EUR): 221154.6
Participants: 1
Project status: CLOSED

Unlike in animals, the formation and growth of the plant body is strongly influenced by the presence of a rigid structure encapsulating the cell – the cell wall. Plant development must therefore be coordinated with the synthesis and remodelling of highly complex cell wall structure. Cell elongation and cell division are the two main processes which give rise to the plant body. Whilst cell wall properties during cell elongation have been relatively well studied on Arabidopsis hypocotyls and on Chara internodes, description of cell wall behaviour associated with cell division is largely absent. DNA microarray data on synchronous cell cultures suggest up-regulation of many cell wall component acting enzymes in particular points of the cell cycle. Moreover, the concept of plant cytokinesis supposes structural changes in cell walls. We propose to use the state of art technologies in cell, developmental biology and systems biochemistry to describe cell wall related processes in dividing cells. As model systems we will use Arabidopsis plants and cell cultures but also a broad panel of algae, land plants and crop species. Our work will incorporate detailed quantitative and qualitative analyses of the dynamism of the cell wall components and related enzymatic activities at different stages of the cell cycle. We will also employ state of art microscopic and ultramicroscopic techniques to study the spatiotemporal distribution of the cell wall components. This approach will include development of novel technology for in situ and real time detection of various carbohydrates. We will also analyse cellular and developmental consequence of the loss- and gain-of action of the cell cycle regulated cell wall-acting enzymes to get the functional information of molecular pathways leading to proper cell division. Our project thus aims to address fundamental questions regarding plant development at uni- and multicellular level within the evolutionary perspective.

Keywords: l205 glycomics,l303 cell cycle and division,l213 systems biology,plant cell walls,plant models,carbohydrate microarrays,immunological techniques,cell biology,development,evolution
The origin and functional evolution of long non-coding RNAs (EVOLNCRNAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNA molecules that function in a wide range of biological processes, including the inactivation of sex chromosomes, imprinting and the regulation of gene expression. Despite their obvious biological importance, lncRNAs are the least understood class of genomic transcripts. Little is known about how they originate, how they acquire and evolve regulatory capacity, and how they function. Not surprisingly then, little is also known about the role that lncRNAs have played in the evolution of lineage-specific mammalian traits. This proposal combines molecular biology and evolutionary genetics tools to study the evolution and function of lncRNAs, and to evaluate their potential role in the specification of mammalian phenotypes. In this project I propose to generate a comprehensive and well-annotated set of mammalian long intergenic non-coding RNAs (lincRNAs) that – importantly – will include their regulatory regions. With this dataset, I aim to address the two main objectives of this proposal. Objective 1 is to identify the molecular mechanisms that generate novel lincRNAs, including how novel lincRNAs evolve their transcriptional regulation. By studying lncRNAs across 13 species that represent all major mammalian lineages, I will also investigate differences between lineages/species in the types of lncRNAs that they posses. Objective 2 is to identify networks of genes regulated by lincRNAs that underlie novel mammalian traits, and to investigate differences between species/lineages in these gene networks. This proposal will significantly advance the scientific community’s understanding of lncRNAs, including how these molecules have contributed to the functional evolution of mammalian genomes.

Keywords: l201 genomics - comparative genomics - functional genomics,l803 systems evolution - biological adaptation - phylogenetics - systematics,rna biology