Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Effective Communication in Outbreak Management: development of an evidence-based tool for Europe (E-COM@EU)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Netherlands,Germany,United States,Netherlands,United Kingdom,Switzerland,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-02-01
End date: 2016-01-31
Duration (months): 48.0
Total project cost (EUR): 2620373.8
EU funding (EUR): 1999607.0
Participants: 11
Project status: CLOSED

Although scientific knowledge to respond to outbreaks has increased, deficiencies remain in the ability of health authorities to communicate the need for large-scale measures such as vaccination and antiviral therapy and increase its acceptance. For effective behavioural and communication strategies, integration is needed of social, behavioural, communication and media sciences. We bring together these disciplines to go beyond the current knowledge to develop an evidence-based behavioural and communication package for health professionals and agencies throughout Europe in case of major outbreaks. This overall aim is reached through a number of specific objectives: 1) to asses the time-dependent influences of epidemiology and risk communication including media content on human behaviour during the A/H1N1 pandemic; 2) to analyse, using Social Marketing principles, vaccination behaviour, audience segmentation, and vaccination service delivery; 3) to analyse knowledge, attitudes, risk perception, vaccination non-response and reasons for resistance during past epidemics; 4) to apply Discrete Choice Experiments to determine acceptance of preventive measures in the case of epidemic outbreaks; 5) to integrate the key findings of the studies under objectives 1-3 to determine critical factors, groups and media to be addressed in the development of effective strategies; 6) to test behavioural interventions and communication strategies tailored to different target audiences; and 7) to finalize and disseminate a package of evidence-based tools that can be tailored to individual European countries. Our project addresses all topics in the FP7 call text. The first phase has a research emphasis, whereas in the second phase newly developed behavioural intervention and communication strategies are tested and translated into (web application) tools. The final package will be disseminated among health professionals and outbreak management agencies.

Keywords: infectious diseases,pandemic,behavioural change,communication strategy,media,vaccination
Novel Design of Nanostructures for Renewable Energy: Fundamental Questions and Advanced Applications (NANO@ENERGY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Israel
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2016-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Photovoltaics and liquid fuels are poised as major contributors to the global energy market, promising cleaner, renewable sources of energy than fossil fuels. However, the technologies required to make this possibility a reality are limited by their high cost per kWh, and current share of photovoltaics and liquid fuels in the energy market is thus extremely small. One method of reducing the costs of photovoltaics lies in the use of semiconductor nanocrystals to absorb and convert solar photon energy to usable electricity and liquid fuel. Among the advantages of a nanocrystal-based design for photovoltaics are the requirement for thinner absorbing layers, the less energy-intensive refining processes, and their scalability with respect to photovoltaic production. To address these challenges, I plan to initiate a multidisciplinary research project that comprises three separate, but interrelated and complementary, parts that will be conducted in parallel. The first and the main part will be the preparation of novel hybrid nanostructures that have potential for PV and fuel cells applications. The second will focus on a systematic study of the fundamental processes of charge dynamics in the nanoscale regime. The materials and knowledge generated can then be applied in the third part of the project—development of PV and photoelectrochemical devices with scale-up potential for large-scale solar energy exploitation, and examination of benchmark properties (overall efficiency, I V characteristics, external quantum efficiency, hydrogen and liquid fuel production) of our new hybrid materials and devices. These properties will be used as feedback for the synthesis of more complex hybrid structures and for improving our device assembly methods and the choice of materials and/or composites for the devices.

Keywords: synthesis of nanomaterials,hybrid nanostrcutures,photovoltaic,photocatalysis,fuel cell,thermal decomposition,synthesis semiconductor and metals,nanointerfaces,charge separation
Molecular engineering of virus-like carriers (MEVIC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: United Kingdom,United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2016-09-30
Duration (months): 60.0
Total project cost (EUR): 1643736.0
EU funding (EUR): 1643736.0
Participants: 2
Project status: CLOSED

In the last 5 years I have been working on the study of nanoscopic vesicles formed by the assembly in water of amphiphilic block copolymers. These polymer vesicles also known as polymersomes can be designed with size, topology and morphology similar to natural viruses. The synthetic nature of copolymers allows the design of interfaces with various classes of biochemically-active functional groups. This, in combination with precise control over the molecular architecture, determines the degree of order in self-organizing polymeric materials. Such bio-inspired ‘bottom-up’ supramolecular design principles can offer outstanding advantages in engineering structures at a molecular level, using the same long–studied principles of biological molecules. It is self-evident that the highly biocompatible nature of these new amphiphilic copolymer assemblies augurs well for biomedical applications. Indeed, related polymeric micelles and vesicles have already been reported and studied as delivery systems for drugs, gene, and image contrast agents. Herein I propose to engineer new generations of polymersomes whose size, topology, surface chemistry is exquisitely controlled by supramolecular interactions with the aim to control their bioactivity and explore new ways to target specific biological sites via multi-fictionalisation and steric controlled binding. This will be achieved by a balanced combination of novel physico-chemical techniques with tailor-made biological evaluation based on state-of-the-art cell culture methods as well as in vitro and in vivo high content screening. My long-term aim is to set-up new design principles for nanoparticles for biomedical applications together with a thorough biomedical fast screening that will enable safe and fast translation into the clinic as well as benchmarking nanotoxicological methodologies.

Keywords: block copolymers,polymersomes,endocytosis,dna,rnai,aon,and cell targeting
Advanced Antenna Architecture for THZ Sensing Instruments (AAATSI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Systems and communication engineering
Countries involved: Netherlands
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2017-10-31
Duration (months): 72.0
Total project cost (EUR): 1499487.0
EU funding (EUR): 1499487.0
Participants: 1
Project status: CLOSED

The Tera-Hertz portion of the spectrum presents unique potentials for advanced applications. Currently the THz spectrum is revealing the mechanisms at the origin of our universe and provides the means to monitor the health of our planet via satellite based sensing of critical gases. Potentially time domain sensing of the THz spectrum will be the ideal tool for a vast variety of medical and security applications. Presently, systems in the THz regime are extremely expensive and consequently the THz spectrum is still the domain of only niche (expensive) scientific applications. The main problems are the lack of power and sensitivity. The wide unused THz spectral bandwidth is, herself, the only widely available resource that in the future can compensate for these problems. But, so far, when scientists try to really use the bandwidth, they run into an insurmountable physical limit: antenna dispersion. Antenna dispersion modifies the signal’s spectrum in a wavelength dependent manner in all types of radiation, but is particularly deleterious to THz signals because the spectrum is too wide and with foreseeable technology it cannot be digitized. The goal of this proposal is to introduce break-through antenna technology that will eliminate the dispersion bottle neck and revolutionize Time Domain sensing and Spectroscopic Space Science. Achieving these goals the project will pole vault THz imaging technology into the 21-th century and develop critically important enabling technologies which will satisfy the electrical engineering needs of the next 30 years and in the long run will enable multi Tera-bit wireless communications. In order to achieve these goals, I will first build upon two major breakthrough radiation mechanisms that I pioneered: Leaky Lenses and Connected Arrays. Eventually, ultra wide band imaging arrays constituted by thousands of components will be designed on the bases of the new theoretical findings and demonstrated.

Keywords: antennas,antenna arrays,dielectric lenses,green's functions,thz technology,ultra wide band antennas
Electrochemistry in fluidic nanodevices: From fundamentals to integrated sensor platforms (ECNANO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Netherlands
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

I propose to explore the frontiers of electrochemistry at the nanometer scale by developing new experimental approaches based on lithographically fabricated fluidic nanodevices. This will allow groundbreaking experiments on a broad range of fundamental topics including double layer structure, screening in ionic liquids, nanoscale hydrodynamics and the dielectric response of single macromolecules. It will also lay the foundations for new analytical techniques based on electrochemical single molecule recognition and targeted at integration with state-of-the-art electronics on a single chip. The latter combination could potentially bring about a revolution in (bio)sensing technology on a scale comparable to those which have already taken place in computing and communications. My first focus will be on nanofabricating sub-femtolitre channels and chambers in which single or small numbers of redox-active molecules can be detected and manipulated using electrochemistry at pairs of embedded electrodes. Simultaneously, I will explore the capabilities electrochemical impedance spectroscopy using nanoelectrodes at frequencies up to 200 MHz. Such a combination of ultra-short length scales and high frequencies has heretofore remained inaccessible and will be made possible here by using electrodes that form an intrinsic part of an integrated detection circuit. This research has a truly exploratory character, as few investigators so far have attempted to combine nanofluidics, modern microelectronics and electrochemistry. Doing so will test our microscopic understanding of electrochemical processes, enable new classes of experiments, and push the limits of electrochemistry as an analytical method. There is thus a high likelihood that further new concepts and applications will emerge over the course of this multidisciplinary program.

Keywords: nanofluidics,electrochemistry,redox cycling,electrochemical impedance spectroscopy,nanoelectrodes,(bio)sensors.
Bioreactor-based, clinically oriented manufacturing of engineered tissues (BIO-COMET)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Switzerland,United Kingdom,Croatia,Italy,Germany,Canada
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 8326237.0
EU funding (EUR): 5994367.1
Participants: 9
Project status: CLOSED

Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining wide-spread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commercialization of engineered products. Similar to other biotechnology sectors (e.g., vaccines or recombinant protein production), bioreactor systems could play a central role in establishing engineered tissues in the clinic. In fact, by automating and streamlining manufacturing processes, they would allow to improve product reproducibility, safety, standardization and possibly reach cost-effectiveness. This project aims at the development, pre-clinical and clinical testing of a sensor-based bioreactor system for the production of functional, autologous engineered grafts with reproducible properties. The bioreactor-based manufacturing paradigm will be addressed in the specific context of cartilage repair. Innovative features of the proposed tissue engineering strategy will include: (i) an automated and controlled production system, (ii) bioreactor conforming to regulatory guidelines, (iii) simplified, streamlined, and scalable tissue engineering process, (iv) on-line monitoring of culture/quality parameters, and (v) data management systems for traceability. To achieve these goals, BIO-COMET brings together internationally renowned leaders in the field of regenerative medicine, from academic, clinical and industrial research institutions. Successful implementation of the project will be instrumental to extend use of bioreactor-based platforms beyond cartilage tissue engineering, with the ultimate goal to facilitate broad utilization and commercialization of cell-based grafts as therapeutic solutions.

Keywords: bioreactor,tissue engineering,clinical trial,cartilage graft,nasal chondrocytes,articular chondrocytes,cartilage repair,regenerative medicine,biosensors
Improvements to Integrate High Pressure Alkaline Electrolysers for Electricity/H2 production from Renewable Energies to Balance the Grid. (ELYGRID)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Spain,Switzerland,France,Germany,Belgium,Spain,France,Spain
Call:  (FCH-JU-2010-1, 2010)
Start date: 2011-11-01
End date: 2014-12-31
Duration (months): 38.0
Total project cost (EUR): 3701178.33
EU funding (EUR): 2105017.0
Participants: 11
Project status: CLOSED

ELYGRID Project aims at contributing to the reduction of the total cost of hydrogen produced via electrolysis couple to Renewable Energy Sources, mainly wind turbines, and focusing on mega watt size electrolyzes (from 0,5 MW and up). The objectives are to improve the efficiency related to complete system by 20 % (10 % related to the stack, and 10 % electrical conversion) and to reduce costs by 25%. The work will be structured in 3 different parts, namely: cells improvements, power electronics, and balance of plant (BOP). Two scalable prototype electrolyzers will be tested in facilities which allows feeding with renewable energies (photovoltaic and wind)

Keywords: high pressure alkaline electrolysers,renewable energies,power electronics,balance of plant,stack,energy storage,cost reduction,stack improvement,membrane development,electrodes,lca,rcs
Imaging of Neuroinflammation in Neurodegenerative Diseases (INMIND)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Italy,Austria,France,Italy,Spain,Belgium,France,Netherlands,United Kingdom,Sweden,Belgium,Denmark,Finland,United Kingdom,Australia,Hungary,Germany,Italy,Italy,Denmark
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-03-01
End date: 2018-02-28
Duration (months): 72.0
Total project cost (EUR): 24706599.82
EU funding (EUR): 11998478.0
Participants: 31
Project status: CLOSED

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are: (i) to identify novel mechanisms of regulation and function of microglia under various conditions (inflammatory stimuli; neurodegenerative and -regenerative model systems); (ii) to identify and implement new targets for activated microglia, which may serve for diagnostic (imaging) and therapeutic purposes; (iii) to design new molecular probes (tracers) for these novel targets and to implement and validate them in in vivo model systems and patients; (iv) to image and quantify modulated microglia activity in patients undergoing immune therapy for cognitive impairment and relate findings to clinical outcome. Within INMiND we bring together a group of excellent scientists with a proven background in efficiently accomplishing common scientific goals (FP6 project DiMI, www.dimi.eu), who belong to highly complementary fields of research (from genome-oriented to imaging scientists and clinicians), and who are dedicated to formulate novel image-guided therapeutic strategies for neuroinflammation related neurodegenerative diseases. The strength of this proposal is that, across Europe, it will coordinate research and training activities related to neuroinflammation, neurodegeneration/-regeneration and imaging with special emphasis on translating basic mechanisms into clinical applications that will provide health benefits for our aging population. With its intellectual excellence and its crucial mass the INMiND consortium will play a major role in the European Research Area and will gain European leadership in the creation of new image-guided therapy paradigms in patients with neurodegenerative diseases.

Keywords: microglia,molecular imaging,mci,als,immune therapy,regeneration
Low temperature hydrogen production from second generation biomass (HYTIME)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Netherlands,Germany,Italy,Germany,Austria,Netherlands,France,Netherlands,Poland
Call:  (FCH-JU-2010-1, 2010)
Start date: 2012-01-01
End date: 2015-06-30
Duration (months): 42.0
Total project cost (EUR): 3057249.8
EU funding (EUR): 1606900.0
Participants: 9
Project status: CLOSED

The aim of HyTime is to deliver a bioprocess for decentral H2 production from 2nd generation biomass with a productivity of 1-10 kg H2/d. The novel strategy in HyTime is to employ thermophilic bacteria which have shown superior yields in H2 production from biomass in the previous FP6 IP HYVOLUTION. Biomass in HyTime is grass, straw, molasses or unsold organic goods from supermarkets. The biomass is fractionated and converted to H2 at high efficiency unique for thermophilic fermentation. Dedicated bioreactors and gas upgrading devices for biosystems will be constructed to increase productivity. The H2 production unit will be independent of external energy supply by applying anaerobic digestion to valorize residues. HyTime adds to the security of supply H2 from local sources and eradicates geopolitical dependence. HyTime builds on HYVOLUTION with 5 partners expanding their research efforts. Three new industrial partners, 2 of which are NEW-IG members, have joined this team with specialist expertise in 2nd generation biomass fractionation and gastechnology. This way a pan-european critical mass in agro- and biotechnological research, the energy and hydrogen sector is assembled to enforce a breakthrough in bioH2 production. The participation of prominent specialists with interdisciplinary competences from academia (1 research institute and 2 universities) and industries (3 SMEs and 2 industries) warrants high scientific quality and rapid commercialization by exploitation of project results and reinforces the European Research Area in sustainable issues. The partners in HyTime have a complementary value in being developers or stake-holders for new market outlets or starting specialist enterprises stimulating new agro-industrial activities to boost the realization of H2 from renewable resources. The concept of HyTime will facilitate the transition to a hydrogen economy by increasing public awareness of the benefits of a clean and renewable energy carrier.

Keywords: hydrogen,fermentation,enzymes,pretreatment,waste biomass,second generation biomass,high rate bioreactor