Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Study of the use of the ESS facility to accurately measure the neutrino cross-sections for ESSnuSB leptonic CP violation measurements and to perform sterile neutrino searches and astroparticle physics (ESSnuSBplus)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: France,Bulgaria,Sweden,Switzerland,Italy,Spain,Japan,Croatia,Germany,Türkiye,Greece
Call: Research infrastructure concept development (HORIZON-INFRA-2022-DEV-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5003772.5
EU funding (EUR): 3000000.0
Participants: 20
Project status: SIGNED

After the success of the H2020 ESSνSB Design Study proving the feasibility of the upgrade of the European Spallation Source to become, in addition to a neutron facility, also a very competitive neutrino facility, we propose here a study to reinforce and develop complementary features to this proposal in order to improve and widen the scientific and technological scope. The key objective of the H2020 ESSνSB Design Study was to demonstrate the feasibility of using the European Spallation Source (ESS) proton linac to produce the world's most intense neutrino beam concurrently with the 5 MW proton beam to be used for the production of spallation neutrons. After accomplishing all deliverables and the publication of the ESSνSB CDR, this is now fully demonstrated. With the present Design Study, it is proposed to take further steps towards its realization by introducing complementary studies and enlarging its scope by making studies on synergetic aspects of the project. The ESSνSB+ high-level objectives are to: • Study the civil engineering needed for the facility implementation at the ESS site as well as those needed for the ESSνSB far detector site. • Study the feasibility and implementation of a special target station for pion production and extraction for injection to a low energy nuSTORM decay ring and to a low energy Monitored Neutrino Beam decay tunnel, for neutrino cross-section measurements. • Study the low energy nuSTORM decay ring and the injection of the pions and muons from the special target station. • Study the low energy ENUBET-like Monitored Neutrino Beam decay tunnel and the injection of the pions and muons from the special target station. • Study the capabilities of the proposed setup for sterile neutrino searches and astroparticle physics. • Promote the ESSνSB project proposal to its stakeholders, including scientists, politicians, funders, industrialists and the general public in order to pave the way to include this facility in the ESFRI list.

Keywords: physics particles neutrinos oscillation ess essnusb cross sections sterile cpv
Rethinking Images as the Book of the Illiterate: Towards a New Acoustic Understanding of Religious Art (1550-1650) (AurArt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

AurArt investigates auditory perception in early modern religious art, by exploring the Catholic debate over the Gregorian definition of images as the "book of the illiterate" developed in Italy after the Council of Trent (1563). Drawing on a wide range of literary and figurative primary sources, such as treatises on the justification of images and contemporary Jesuit frescoes, the project demonstrates the close interaction between seeing, reading, and listening in the reception of sacred texts and pictures. By rethinking hearing in early modern religious art, AurArt seeks to fill both a thematic and a methodological gap in the emerging field of study at the intersection of art history, sound studies, and religion studies. The overall goal of the project is to offer a new acoustic understanding of early modern sacred images, which will contribute to the current transformative change leading to a new interpretation of art as a cultural phenomenon involving the whole body and its sensorium. My research will be supervised by Prof. Ralph Dekoninck, a specialist in the field of early modern religious art and literature, and an expert in artistic theories and sensible practices related to sacred images. The fellowship will be hosted at the Group of Early Modern Cultural Analysis (GEMCA) at UCLouvain and involves a unique two-way knowledge transfer based on sharing interdisciplinary methodologies for developing new sensory approaches to art history. The results will be disseminated through the publication of four articles, the development of a website and the organization of two international research workshops. AurArt also includes the design of a museum auditory device at the MuséeL of Louvain-la-Neuve, in collaboration with Muriel Damien (MuséeL/GEMCA). The device project involves a synergetic interaction between research, artistic creation, and sensory heritage mediation, with the aim of fostering an embodied acoustic experience of religious artworks accessible to all.

Keywords: sound studies,sensory history,visual culture,sensory heritage mediation
A Metamaterial-based technology to create Electricity from Light (AMELI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

AMELI aims at developing a family of hot carrier devices that operate on a technology discovered by the PI during the course of his ERC-CoG project. This hot carrier technology does not rely on a P-N junction (or one of its many derivatives) to create electricity, giving access to a parameter space that is different from that of traditional solar cells. The goal of AMELI is to assess the potential for disruption of this approach and to propose a first proof of concept photovoltaic (if we can reach a 10% energy conversion efficiency threshold) or photodetector prototype at the end of the project.
Growing Machines Capable of Rapid Learning in Unknown Environments (GROW-AI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1994225.0
EU funding (EUR): 1994225.0
Participants: 1
Project status: SIGNED

Despite major advances in the field of artificial intelligence, especially in the field of neural networks, these systems still pale in comparison to even simple biological intelligence. Current machine learning systems take many trials to learn, lack common-sense, and often fail even if the environment only changes slightly. The enormous potential of autonomous machines remains unfulfilled and we still lack robots to fill our dishwashers or go on autonomous search-and-rescue missions. The grand goal of GROW-AI is to create machines with a more general intelligence, allowing rapid adaption in unknown situations. In stark contrast to current neural networks, whose architectures are designed by human experts and whose large number of parameters are optimized directly, evolution does not operate directly on the parameters of biological nervous systems. Instead, these nervous systems are grown and self-organize through a much smaller genetic program that produces rich behavioral capabilities right from birth and the ability to rapidly learn. Neuroscience suggests this "genomic bottleneck" is an important regularizing constraint, allowing animals to generalize to new situations. However, currently there does not exist a solution to creating a similar system artificially. We address this challenge with two ambitious ideas. First, we will learn genomic bottleneck algorithms instead of manually designing them, exploiting recent advances in memory-augmented deep neural networks that can learn complex algorithms. In addition, we will co-optimize task generators that provide the agents with the most effective learning environments. Taking inspiration from the fields of artificial life, neurobiology, and machine learning, we will investigate if algorithmic growth is needed to understand and create intelligence. If successful, this project will greatly improve the autonomy of machines and significantly increase the range of real-world tasks they can solve.

Keywords: artificial life,neuroevolution,developmental algorithms,morphogenesis,synaptic plasticity
SCIENCE4FUTURE: FESTIVAL DER WISSENSCHAFT KIEL REGION 2024/2025 (SCIENCE4FUTURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Germany,France,Poland
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-03-01
End date: 2025-12-31
Duration (months): 22.0
Total project cost (EUR): 224300.0
EU funding (EUR): 224300.0
Participants: 24
Project status: SIGNED

Approaching its 10th anniversary in 2025, the hugely popular European Researchers’ Night will return in 2024/25 to the Kiel region as a true science festival with a new scope in terms of geography, duration and activities. Not only will it bring together all of Kiel region’s 12 research organisations comprising all academic disciplines showcasing their scientists and work to the public, but will also include for the first time activities organised by our European twinned cities from France and Poland in close collaboration with the European University of the Seas (SEA-EU). Another novelty will be an extended programme of pre-events as well as the Rent-a-Scientist and Rent-a-Science-Film formats across the region’s four major cities and the biggest sea resort (Kiel, Rendsburg, Eckernförde, Plön, Laboe). This will enhance awareness of the project and its messages beyond the region as well as attract more visitors to the NIGHT itself. Finally, the NIGHT will showcase for the first time not only the careers of researchers in and outside of academia, but also employment opportunities in research for non-academic research support staff to ensure the long-term viability of the research sector in our region. SCIENCE4FUTURE will focus on the locally-relevant, internationally significant and interdisciplinary themes of climate change, mobility, health and growth as well as Europe.Through more than 100 different activities in pre-events and during the NIGHT in Kiel region, the general public,young people and educators will learn about the the researchers’ work, their careers and their achievements. With the support of over 40 German, French and Polish institutions, partners from SEA-EU from the public, private and non-governmental sector and the active involvement of over 300 researchers, SCIENCE4FUTURE thus establishes itself as a truly European NIGHT and the largest public event dedicated to science-communication and science-education in Northern Germany.

Keywords: science communication,outreach,research,innovation,impact,growth,mobility,health,university alliances,sustainability
Multi-level Circular Process Chain for Carbon and Glass Fibre Composites (MC4)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Austria,Spain,Netherlands,Germany,France,Belgium,Italy,Poland
Call: Ensuring circularity of composite materials (Processes4Planet Partnership) (RIA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-04-01
End date: 2025-03-31
Duration (months): 36.0
Total project cost (EUR): 7503548.75
EU funding (EUR): 7503545.0
Participants: 16
Project status: CLOSED

Each year about 110.000t of carbon fibre composite parts and 4.500.000t of glass fibre composites are used. 98% of these parts end up in landfills at the end of their life. To address this problem the MC4 project aims at establishing a multi-level circular process for carbon and glass fibre composite. Multi-level means that processes will be developed for short-term implementation with immediate impact and for the longer term with a wider impact on industry. Carbon and glass fibre have substantially different costs and the project takes this into account by developing economically feasible procedures that are based on chemical matrix/fibre separation for carbon fibre and on a new type of resing for the direct re-use of the composite for glass fibre. Quality grading of the recycled material will be a key element to ensure a proper use in the different domains. Within the supply chain investigated in the project the goal is to achieve a recycling rate of at least 60%. As an additional benefit, the project will enable European material manufacturers to develop their own, patented processes for manufacturing of recycled material. Currently, 80% of the manufacturing of virgin carbon and glass fibre is taking place outside of Europe and the manufacturing technologies used inside of Europe are often licensed from foreign countries. MC4 puts particular emphasis on the design and manufacturing of best practice examples of parts made from recycled materials. For five different domains, including automotive, aerospace, sports equipment, boats and urban furniture, composite products will be manufactured, with the aim of demonstrating the use of recycled material and enhancing the demand side for recycled material in the different domains. The consortium includes process developers, material manufacturers and SME end users, who manufacture composite parts. It covers the whole value chain and thus enables the creation of real circular process for composites.

Keywords: carbon fiber,glass fiber,quality
Reversing the advantage of cancers with Hypoxia and Homologous Recombination Defect (HRD) by using a pan-cancer, composite, lesions-specific biomarker (ReverseTheAdvantage)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-08-01
End date: 2024-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Hypoxia-activated prodrugs (HAPs) are a great concept in particular in association therapies more efficient on well-oxygenated cells, such as immunotherapies. CP-506 is a third generation HAP with optimal PK for which we confirmed in more than 20 tumor models that presence of tumor hypoxia is a requisite for prodrug activation. We already had an AI/radiomics-based proprietary IP on a solution to identify hypoxia from standard imaging. Another important determinant for efficacy was the presence of a defective homologous recombination (HRD), a pathway needed to repair the DNA damage of the alkylating warhead of CP-506. A genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD, available open source) is able to detect HRD better as compared to assessing mutation of key genes. It is therefore essential to have a validated software solution integrating both biomarkers. This solution, further developed in this project, will be able to capture intrapatient heterogeneity and make a outcome prediction per patient and per lesion.
Center of Excellence for Exascale in Solid Earth - Second Phase (ChEESE-2P)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Spain,Italy,Iceland,Germany,France,Finland,Croatia,Norway
Call: Centres of Excellence for supporting supercomputing applications for Science and Innovation (HORIZON-EUROHPC-JU-2021-COE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 7690590.53
EU funding (EUR): 3844043.77
Participants: 19
Project status: SIGNED

The scientific ambition of ChEESE-2P is to prepare 11 community flagship codes to address 12 domain-specific Exascale Computational Challenges (ECC), enlarging the areas covered during the first implementation phase (computational seismology, magnetohydrodynamics, physical volcanology, and tsunamis) with two additional disciplines (geodynamics and modeling of glacier hazards). Codes will be optimized in terms of performance on different types of accelerators, scalability, deployment, containerization, and portability across current pre-exascale systems and hardware architectures emerging from the EuroHPC Pilots by co-designing with mini-apps. Optimization will also include heterogeneous single-node and multi-node performance, as well as continuous efficiency monitoring using the Performance Optimisation and Productivity (POP) metrics. Emphasis will be given on the uptake by science, public administration and industry, including training and capacity building in cooperation with National Competence Centers (NCCs). Codes and workflows will combine to farm a new generation of 9 Pilot Demonstrators (PDs) underpinned by concepts like multi-scale, multi-source, and multi-physics. The PDs will materialise in 15 Simulation Cases (SCs) representing capability and capacity use cases of particular relevance in terms of science, social relevance, or urgency (the capability SCs include 4 potential Scientific Grand Challenges, i.e. cases that can require an extreme-scale access mode). The SCs will produce relevant EOSC-enabled datasets and enable services on aspects of geohazards like urgent computing, early warning forecast, hazard assessment, or fostering an emergency access mode in EuroHPC tier-0/tier-1 systems for geohazardous events (earthquakes, tsunamis and volcanoes), including access policy recommendations. Finally, ChEESE-2P will liaise, align, and synergize with other domain-specific European projects and longer-term mission-like initiatives like Destination Earth.

Keywords: solid earth,code optimization,services,geohazards,urgent computing
Unraveling redox regulation in cancer stem cells as a potential therapeutic target for breast cancer (STEMOX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: CLOSED

ABSTRACT Breast cancer (BC) is the most frequently diagnosed cancer and the first cause of cancer death in women worldwide. In many tumors, including BC, there is a population of cancer stem cells (CSCs) characterized for unlimited self-renewal and being resistant to conventional cancer therapies eventually leading to tumor relapses and metastases. Breast CSCs (BCSCs) show high cellular plasticity and are capable of shifting between a proliferative epithelial-like (E) state and a quiescent mesenchymal-like (M) state. This plasticity of BCSCs facilitates their ability to initiate and grow primary tumors, invade the basement membrane, traverse tissue vasculature, and ultimately colonize distant organs to form clinically significant metastases. It has been recently proposed that redox regulation might play a significant role in BCSCs plasticity and aggressiveness. We hypothesize that the redox-regulated BCSC plasticity and the highly oxidative metabolism of E-BCSCs might be a vulnerability that could be exploited as a novel BC therapy. We aim to characterize BCSCs in terms of individual ROS production, transducing our breast cancer patient-derived organoids (PDOs) collection with genetically-encoded redox sensors. We will treat breast cancer PDOs with conventional chemotherapy and inhibitors of PI3K to study changes in redox signaling occurring in the tumor. Finally, we will attempt to target these cells and modulate their redox regulation in order to differentiate and eliminate them. We expect to better understand the redox-regulation of BCSCs, to subsequently modulate BCSC redox state to target and eliminate these cells, increasing conventional therapy effectiveness and decreasing the minimal residual disease and cancer spread in BC patients, contributing to overall survival.

Keywords: breast cancer,cancer stem cells,redox,organoids,redox sensors,hydrogen peroxide
Awash Baringo Correlation and Cyclostratigraphy: Human evolution and paleoclimate (ABCCycle)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

Age control is central in the study of human evolution as most if not all major hypotheses in palaeoanthropology and archaeology critically depend on it. It is further generally assumed that adaptation to new environments was the catalyst to key biological and cultural innovations in our ancestral lineage. However, in most cases, a high-resolution temporal framework to test whether human evolution is driven by environmental and climate change is lacking. However, such a framework can be provided by astronomical dating or tuning. ABCCycle (Awash Baringo Correlation and Cyclostratigraphy) therefore aims to i) construct a high-resolution astronomically-tuned age model for two key paleontological and archaeological localities in East Africa, using a novel combination of relative paleo-intensity (RPI) and rockmagnetic cyclostratigraphy in order to ii) critically test if climate and environmental change controlled the distribution and evolution of hominins in the East African Rift Valley. This project builds upon the magnetostratigraphic expertise developed by Mark Jan Sier (MJS) during his PhD and postdoc as well as his privileged access to the drilled sediment cores of several localities from the East African Rift Valley, including Baringo/Tugen Hills Barsemoi and North Awash Region. MJS will provide entirely new approaches to the chronological and environmental control of this region by applying an integrated cyclostratigraphic approach for geological dating and correlation as has been developed at the department of Earth Sciences of Utrecht University.

Keywords: rockmagnetic cyclostratigraphy,geochronology,human evolution,east africa,icdp