Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Metabolic Dynamics in Colorectal Cancer (MDCRC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-07-19
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Metabolic reprogramming has recently emerged as a key hallmark of cancer. Despite many efforts made to identify metabolic properties of cancer cells, there is a complete lack of understanding of the specific steps in the tumorigenic process when this metabolic rewiring occurs and its biological consequences. In this regard, our previous work has revealed a critical role of glucose metabolism in driving tumor initiation, in particular in the intestine. Importantly, recent studies have demonstrated that intestinal stem cells (ISCs) are the cell of origin of colorectal cancer (CRC), and our preliminary data suggests that glucose metabolism could be important for ISC activity. Based on these findings, we propose to study the specific metabolic properties of intestinal stem cells (ISCs) and its relevance in stem cell dynamics and CRC initiation and progression. Specifically, we will develop three aims: 1. To analyze the role of metabolic reprogramming in ISCs and its contribution to CRC by employing a combination of genetic, metabolic and imaging techniques. 2. To study the metabolic evolution of CRC. In this aim, by using patient-derived xenografts and intestinal organoids expressing a genetically encoded metabolic reporter, we will analyze glucose metabolism in vivo at a single cell level to define step-wise the role of metabolic reprogramming in CRC progression. All together, the successful completion of this proposal will identify the specific cells and steps during CRC where glucose metabolism is functionally relevant and the underlying molecular mechanisms, thus expanding our view of metabolic reprogramming beyond the idea of being just an adaptation to increased proliferation. Importantly, the results derived from this project could potentially be used to improve current therapies by targeting specific metabolic pathways.

Keywords: colorectal cancer,metabolic reprogramming,intestinal stem cells,tumor initiating cells,intravital imaging
Hydrogen production by membrane free chemical – electrochemical systems (HYMEFCECS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-06-01
End date: 2018-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Until recently it was believed to be impossible to produce hydrogen through water electrolysis systems, without an electrochemical oxygen production process and without a membrane. However, in the past few years, our team was able to develop a new technological configuration which divides the water splitting process into two phases : (1) an efficient electrochemical hydrogen production followed by a (2) spontaneous chemical oxygen production phase. By eliminating the inefficient electrochemical water oxidation reaction (OER) we achieve a significant increase in hydrogen production efficiency. Furthermore, reducing the danger of mixing hydrogen and oxygen eliminates the need for a membrane. A membrane-free system enables high pressure hydrogen production without the risk of gas mixture or membrane failure. Moreover, as the membrane failure is the main cause for malfunctions and offline times of alkaline and PEM electrolyzer, our technology improves system reliability and energy efficiency. The purpose of this PoC is to further develop our basic lab prototype to demonstrate two potential commercial applications:(1)Power to Gas (P2G) storage of renewable energy (demonstrating the ability to produce hydrogen with high efficiency and under high peaks) and (2) On-site hydrogen production for hydrogen refuelling stations (demonstrating purity and durability under high-pressure). Furthermore, HYMEFCECS, will include an in-depth user requirements analysis (combining business, economic and technical inputs); devising a proper business model and business plan per two target markets, financial forecasting, Intellectual Property and an Investor Toolkit.

Keywords: solar energy conversion,photo electrochemical cell pec,safe hydrogen production
INNovative Cost Improvements for BALANCE of Plant Components of Automotive PEMFC Systems (INN-BALANCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Spain,Austria,Germany,Germany,Germany,Spain,Sweden,Switzerland
Call: Development of industrialization-ready PEMFC systems and system components (H2020-JTI-FCH-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-10-31
Duration (months): 58.0
Total project cost (EUR): 6156288.75
EU funding (EUR): 4994538.75
Participants: 11
Project status: CLOSED

The aim of INN-BALANCE is to develop a novel and integrated development platform for developing advanced Balance of Plant components in current fuel cell based vehicles, in order to improve their efficiency and reliability, reducing costs and presenting a stable supply chain to the European car manufacturers and system integrators. Accordingly, INN-BALANCE technical objectives are (i) to develop highly efficient and reliable fuel cell BoP components; (ii) to reduce costs of current market products in fuel cell systems; (iii) to achieve high technology readiness levels (TRL7 or higher) in all the tackled developments; and (iv) to improve and tailor development tools for design, modelling and testing innovative components in fuel cell based vehicles. To this end, a European Consortium composed by major automotive companies, consulting groups, research institutes and universities was established. INN-BALANCE will be focused on four main general topics; first of all on new components developments, addressing the latest changes and trends in fuel cells vehicles technology, from new air turbo-compressor, anode recirculation/injection module and advanced control/diagnosis devices to new concepts of thermal management and anti-freeze units based on standard automotive components; secondly, on the vehicle integration and validation of the components in a TRL7 platform placed at a well-known car manufacturing platform; thirdly, providing innovative and cost optimized manufacturing processes especially developed for automotive BoP components; finally, on the results dissemination and exploitation, new technology broadcasting and public awareness of new, low-cost and reliable clean energy solutions in Europe bringing at the same time highly qualified new job opportunities.

Keywords: fuel cell,components,balance of plant,manufacturing,cost effective,automotive
Modeling the chronology of deep ocean circulation changes during abrupt climate transitions (OCTANT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-19
End date: 2018-03-18
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The deep ocean circulation affects climate and the global carbon cycle. A prerequisite for improving confidence in future climate projections is the accurate reproduction of past deep ocean circulation changes by models. However our understanding of such changes in terms of transport pathways and transit times is impeded by ambiguities in the chronology of ocean archives. This project aims at helping resolve such ambiguities by investigating to what extent the temporal evolution of the ocean circulation during abrupt climate transitions may be inferred from deep-sea sediment cores. In this purpose we use the Earth system Model developed at Max-Planck Institute for Meteorology (MPI-ESM) fully coupled to an Ice Sheet Model (PISM). The coupled model naturally produces freshwater surges which exhibit the basic features of Heinrich events (massive discharges of icebergs to the ocean which occurred during the last glacial period). We implement simple formulations for tracers which document ventilation and water mass distribution in deep ocean sediment cores (O18, C14, C13) in addition to age tracers. These age tracers allow distinguishing between the effects of varying conditions at the air-sea interface and water masses reorganization, while providing information on the relative contributions of specific water masses. We then investigate the sequence of events in the deep ocean during Heinrich events, and the potential departures of proxy-based ages and transit times from the actual ventilation time scales. A coherent description of the temporal and geographical deep ocean ventilation evolution during abrupt climatic changes and associated uncertainties will then be obtained. Such a chronological framework will be beneficial to those investigating past climates by means of ocean archives or modeling studies.

Keywords: ocean ventilation,tracers,abrupt change,isotopes
Cell-to-cell variability during symmetry breaking in organoid development (SymBreakOrganoid)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Cell-to-cell variability is an inherent property of populations of cells. As a starting point for symmetry breaking events, it is also an essential building block for self-organised pattern forming systems. Nonetheless, the sources and roles of cell-to-cell variability in symmetry-breaking events during collective cell behavior await a quantitative and mechanistic understanding. To obtain these insights, we will use a model system of intestinal organoids, which recapitulates most of the processes of morphogenesis and patterning observed in intestinal tissue. In this system, the symmetry-breaking event is observed when, despite all single cells in a growing organoid are exposed to uniform environments, only a fraction of cells acquires specific cell fates, generating asymmetric structures such as crypts and villi. This project aims to uncover the extent, sources, and consequences of cell heterogeneity. To this end, we will use advanced multiplexed imaging of intestinal stem cells in 3D organoid development to monitor quantitatively the behaviour of each single cell in the system. Initially, we will identify potential sources of cell-to-cell variability, such as the microenvironment or the cell cycle. Next, we will create models to identify predictors of symmetry breaking and patterning. In parallel, we will determine the extent of cellular heterogeneity by single-cell RNA sequencing during organoid formation. Finally, we will test if cellular heterogeneity is necessary and sufficient to induce symmetry-breaking of intestinal organoids by experimentally inducing and perturbing cell-to-cell variability. Thus, this research proposal will address a major question in developmental biology and collective cell behavior, namely how single cells exposed to a uniform growth-promoting environment generate asymmetric structures. Moreover, it will unravel how local interactions between single cells give rise to emergent, self-organized patterns.

Keywords: symmetry breaking,cell to cell variability,quantitative biology,intestinal oranoids
THz imaging technology for public security (TERASEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The objectives of TERASEC project entail the activities aimed at pre-commercial validation of the technological performances and market potential of a novel device for the detection of security threats, such as weapons, explosives, drugs etc.. The functionality of TERASEC is enabled through combination of superconducting and ferromagnetic materials that delivers frequency selective THz sensors showing unprecedented sensitivity (single-photon resolution), fast response time, high dynamic range, and low noise-equivalent-power. Specifically, starting from the outstanding outcomes reached so far, the capacity of the TERASEC system to detect the above threats with given level of accuracy, range and selectivity will be verified in accordance with the requirements of prospect users (to be collected during the project implementation). Moreover, a detailed market, IPR and regulatory compliance study will be carried out, in order to enable smooth implementation of TERASEC in the complicated context of the public security market. To enhance this, an advisory board gathering Key Opinion Leaders of the sector will be secured and involved into project activity throughout all the project duration. In parallel, comprehensive communication strategy addressing all the stakeholders of the relevant value chain will be rolled out, with strong focus on prospect consumers and users, so to ensuring market traction. Overall, the goal of TERASEC is to deliver an unrivalled novel security scanner device leveraging harmless THz waves, that widely overpasses the accuracy performances of all the conventional systems, thus contributing to the safety of European citizens and the security of sensitive infrastructures.

Keywords: radiation sensing,single photon detection,superconductivity,ferromagnetism,low temperatures,thermoelectricity,thz waves,security scanning systems,thz sensors,detection of security threats
Deciphering cerebellar mitochondrial alterations in Rett Syndrome (MITORett)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-11-18
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Mutations in the X-linked gene encoding methyl-CpG binding protein 2 (Mecp2) can lead to the progressive neurodevelopmental disorder known as Rett syndrome (RTT), characterized by regression in motor, social and cognitive skills, respiratory dysrhythmias and premature lethality. Although few symptomatic treatments exist, nowadays there is still no cure for this disease. Mecp2 acts as transcriptional regulator and its mutations directly affect the expression of targeted transcripts, including mitochondrial (MT) genes. Cerebellum is one of brain regions with larger energy requirements. 43% of its ATP consumption occurs in the molecular layer, where the high-energy demanding parvalbumin (PV)-neurons are positioned. Compelling evidence indicates aberrant MT morphology and functionality in cerebellar biopsies of RTT patients. However, the cellular substrate of these modifications remains largely unknown. In adult cerebellum Mecp2 is preferentially expressed in PV-positive cells. Hence, we hypothesize that RTT in PV-positive neurons might present a particular vulnerability to MT alterations. Thus, in this proposal I will implement a multidisciplinary approach to find candidate MT proteins differentially regulated in cerebellar PV-positive neurons associated with the MT impairments observed in RTT. To tackle this aim, I will perform proteomic, functional and metabolomic studies in MT immunoprecipitates from cerebellar PV-positive neurons of RTT mice. This project will thus give raise to: i) the first exhaustive list of MT proteins dysregulated in these cells in RTT ii) identification of functional and metabolomic impairments affecting MT functionality in PV-positive cells of RTT mice. MITORett project will be a breakthrough in our understanding of RTT and it will provide novel insights into the pathophysiology of this disease by unveiling potential therapeutical targets to focus the forthcoming experiments dedicated on the design of more selective drugs/treatments.

Keywords: rett syndrome,cerebellum,parvalbumin neurons,mitochondria,mitotag,mass spectometry
An Integrated Platform for Developing Brain Cancer Diagnostic Techniques (AiPBAND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Germany,Italy,Italy,Italy,Belgium,Sweden,China,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 3687311.88
EU funding (EUR): 3687311.88
Participants: 20
Project status: CLOSED

The mission of AiPBAND is to train a new generation of entrepreneurial and innovative early-stage researchers (ESRs) in the early diagnosis of brain tumours using molecular biomarkers in the blood, meeting the medical and societal challenges of this emerging field. AiPBAND will focus on gliomas, a range of devastating and progressive brain tumours affecting around 25,000 people each year in Europe and responsible for the majority of deaths from primary brain tumours. Fourteen fellows will be trained by experts in 9 academic and 3 non-academic beneficiaries, belonging to 5 EU member states and 6 partner organizations (4 private sectors and 2 international academic), with fields ranging from neuroscience, engineering (including big data science), healthcare to economics. State-of-the-art technologies will be applied in parallel to (i) identify novel blood biomarkers from patients with gliomas, (ii) design three types of multiplex biosensor (plasmonic-based, graphene-based, and digital ELISA assay-based), (iii) develop a big data-empowered intelligent data management infrastructure, and (iv) develop cloud-based diagnostic systems. Proof-of-concept will be evaluated through clinical trials to assess accuracy, sensitivity and specificity. The elaborately designed individual research projects under the Vitae Researcher Development Framework – carefully arranged into local training courses, network wide events, secondments, personalized career development plans, with strong involvement of the private sector – will ensure exploitation of AiPBAND's achievements, and will maximize the ESRs’ abilities in creative & innovative thinking, triple-i knowledge transformation, and encourage a business-orientated mind-set and entrepreneurship.

Keywords: cancer,biosensing techniques,molecular diagnosis,biomarker discovery,validation,cloud computing,machine learning,business
Enhancing Seafood Ethics and Sustainability: A Values and Ecosystem-based Management Approach (eSEAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

This project aims to explore new ways of securing seafood sustainability by embedding ethics and values in the management framework. In resource management and governance the explicit articulation of values is missing. Values can aid decision-makers in resolving inherent policy trade-offs that emerge at the science-policy nexus. This will facilitate more transparent, accountable, and inclusive public decision-making. eSEAS’ objectives are threefold: a. to promote cutting-edge, interdisciplinary research in the nascent field of seafood ethics; b. to develop three innovative multidisciplinary “fit-for-purpose” decision-support tools to enhance seafood ethics and sustainability; and c. to implement ethical approaches to European management challenges, including the complex multijurisdictional Norwegian-spring spawning and North Sea herring fisheries. The eSEAS action consists of five integrated research and training activities: 1. to define seafood ethics in relation to marine resource sustainability, policy, and governance within a post-normal science approach; 2. to develop an integrated ethical triage approach to assess sustainability with ethical indicators and test it for the balanced harvesting approach; 3. to conduct value chain analyses of European case studies, in response to consumer demand for ethical seafood; 4. to refine the values- and ecosystem-based management approach (VEBMA) I developed by incorporating a robust knowledge quality assessment and a game-theoretical / agent-based modelling approach to search for stable equilibria given stakeholder preferences; and 5. to introduce an ethical approach and apply aspects of the refined VEBMA to the NSS and North Sea herring fisheries management at ICES participatory workshops. Through public engagement and dissemination, eSEAS will catalyze a science-society dialogue and collective actions to enhance seafood ethics and sustainability.

Keywords: values,management,post normal science,policy,assessments,herring fisheries