Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Technology for Sustainability in Organisations: Case Studies on Agricultural Production (TECHSUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

In the contemporary world, technological solutions to the ecological challenges have received a central role. Due to the robust political commitment to technological progress in environmental policy and related path dependencies, modern societies and organisations are increasingly contingent on technological systematizations. The development and adoption of increasingly advanced technological products and processes are taken for granted, and policies persist largely unquestioned. For instance, in the context of agriculture, the development and implementation of new technology is considered to be central in the future of food production and particularly critical in support of sustainable modes of agricultural production. Current governmental incentives and management models are to encourage inertia rather than transitions towards sustainable agricultural production. Despite several ecological benefits of less intensive farming methods and the rising consumer demand on sustainable produce, market shares of non-conventionally produced food remain small. The often-higher, short-term productivity of intensive agriculture, as an outcome of greater use of external input factors, such as chemical fertilizers and pesticides, is too attractive to farmers struggling with profitability. This study hypothesises that in addition to the lack of organisational resources of the farmers (including economic capital, knowledge, and awareness of the ecological challenges) and public policies, a more fundamental barrier to developing sustainable modes of production might prevail, namely technological optimism. With high expectations on future solutions by means of clean technology, agricultural intensification efforts today may continue without interreptions. This study asks: how ecological is the kind of change that technologies are able to deliver?
Decoding at systems-level the crosstalk between the T cell antigen receptor, the CD28 costimulator and the PD-1 coinhibitor under physiological and pathological conditions. (BASILIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-08-01
End date: 2023-07-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Although the T cell antigen receptor (TCR) occupies a central place in T cell physiology, it does not work in isolation and the signals it triggers are tuned by receptors that convey positive (costimulators) and negative (coinhibitors) informations. We lack a satisfying comprehension of the way T cells integrate such multiple inputs to make informed decisions. The proteomics-based methodology we developed around the TCR places us in a favorable situation to decode at systems-level the crosstalk between the TCR, the CD28 costimulator and the PD-1 coinhibitor signaling pathways. The novelty of our approach stems from (1) its use of primary T cells, (2) its capacity to probe the architecture and dynamics of signalosomes resulting from T cell-antigen presenting cell encounters, (3) the attention we pay to the stoichiometry of the studied signalosomes, a key parameter largely ignored in previous studies, and (4) its multidisciplinary nature straddling molecular and organismal scales. Our specific aims are: Aim 1. To understand how the TCR and CD28 signaling pathways cooperate to achieve optimal T cell responses. Aim 2. To determine whether CD28 is the sole target of the PD-1 coinhibitor. Aim 3. To determine how under inflammatory conditions CD28 functions can be superseded by those of OX40, a costimulator of the TNFR superfamily. Aim 4. To unveil how malfunctions of LAT, a key signaling hub used by the TCR, disrupt the TCR-CD28 crosstalk and result in unique pathogenic T cells that by becoming ‘autistic’ to TCR signals and addicted to CD28 signals lead to severe immunopathologies. We think that combining genetic, epigenomics, proteomics, and computational approaches creates ideal experimental conditions to understand at system-levels how TCR, costimulatory, coinhibitory and inflammatory signals are integrated during T cell clonal expansion. Although of fundamental nature, our project should help understanding the harmful role PD-1 plays during anti-tumoral responses.

Keywords: lymphoproliferative disorders,integrative biology,proteomics,gene editing,single cell transcriptomics
Edge-based mechanisms coordinating cell wall assembly during plant morphogenesis (EDGE-CAM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1499771.0
EU funding (EUR): 1499771.0
Participants: 1
Project status: SIGNED

A fundamental question in biology is how multicellular organisms robustly produce organ shapes. The underlying process of morphogenesis involves the integration of biochemical, genetic, and mechanical factors across multiple spatio-temporal scales. In plants, morphogenesis is dominated by the rigid cell wall, which fixes cells in their position. Adjacent cells must therefore coordinate their growth patterns, which are in turn controlled by the mechanical properties of the cell wall. Cell walls are assembled by a complex intracellular trafficking machinery that delivers cell wall components and their associated biosynthetic machinery to different subcellular regions. Based on our recent discovery that a trafficking route directed to cell edges is essential for cell wall assembly and directional growth at the cell and organ scale, we propose that morphogenesis is controlled by a signalling module at cell edges which integrates feedback from the cell wall. This hypothesis provides a mechanistic explanation for the integration of cell and tissue-level mechanical factors into coordinated cell wall assembly. We propose that a receptor-like protein recently identified as the first known cargo of edge-directed trafficking acts as a core component of a cell wall signalling pathway at edges. This proposal aims to test our hypothesis through a combination of experimental and computational methods: (1) at the molecular level, we will identify further components of the signalling module through ligand screening, comparative proteomics, and forward genetics; (2) at the cellular level, we will functionally characterise trafficking pathways and their regulation by edge signalling through quantitative imaging, glycomics, and computational mechanics; and (3) at the organ level, we will dissect how robust growth emerges from edge-based feedback on these trafficking pathways. Collectively, these results will provide a multi-scale mechanistic model of morphogenesis in plants.

Keywords: cell wall assembly,endomembrane trafficking,plant biomechanics,computational mechanics
Centre for New Methods in Computational Diagnostics and Personalised Therapy (Sano)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Germany,Poland,Poland,Poland,United Kingdom
Call: Teaming Phase 2 (H2020-WIDESPREAD-2018-01, 2018)
Start date: 2019-08-01
End date: 2026-07-31
Duration (months): 84.0
Total project cost (EUR): 14998453.75
EU funding (EUR): 14998453.75
Participants: 10
Project status: SIGNED

This proposal describes the creation in Kraków, Poland, of a centre for Computational Medicine. The Centre will be a major driver for European advancement in this rapidly growing sector, developing sophisticated engineering methods for the prevention, diagnosis and treatment of disease, and meeting the overarching worldwide need for radically streamlined healthcare systems. The Centre’s area of operation will be computational medicine: (1) Clinician-led activity can be radically reduced by migrating the majority of routine clinical assessments toward computationally-driven (2) Entirely new approaches to disease diagnosis and management follow the development of novel computed biomarkers of disease, personalised to the individual patient, and typically leading to dramatically reduced costs. The Centre will combine expertise in machine-learning based decision science with fundamental biomarker identification using advanced simulation and data analysis methods. The Centre will act as a core technology provider for industry, fostering modernisation, innovation and increasing productivity, and additionally it will act as a catalyst, attracting new investment and businesses. It will provide an essential link between computational, medical sciences and the industrial sector, thus fostering knowledge and technology transfer and accelerating innovation. The Centre is to be established in Kraków because of several local advantages with regard to the education and research infrastructure, the high concentration of research hospitals and a dynamic entrepreneurial community in life sciences, so being embedded in a highly dynamic and competitive ecosystem The Centre will provide a fully sustainable mix of three advanced technical services, loosely categorised as education, project participation and industrial product development, with these three strands ultimately contributing approximately equally to the Centre’s income stream.

Keywords: computational medicine,healthcare innovation,simulation,high performance computing,clinical decision support system
Chemical Approach to Scalable Fabrication of Hybrid Plasmonic Materials in the Strong-Coupling Regime (SHINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The full control over the nanoscale behavior of light holds incredible potential for the realization of various next-generation technologies with dramatic impact on society, offering revolutionary solutions for cleaner energy resources, faster optical communication systems, data storage and computing, and a more sustainable future (UNESCO’s Sustainable Development Goals number 7 and 9). Strong-coupling light-matter interaction has been the subject of extensive fundamental physics research, while chemists have so far contributed only marginally to its development. Progress in nanosynthesis and nanofabrication have created the perfect environment for the chemistry community to step in and guide the field towards a new class of photonic materials operating in the strong-coupling regime. This proposal will capitalize on my diverse and multidisciplinary training in the fields of chemistry, plasmonics, nano-optics, and materials science for the realization of complex plasmonic architectures coupled with various emitters to establish strong-coupling interactions. I will explore the use of light to modify the energy landscape of these chemical systems, and control their emission and reactivity. I will investigate the fundamental aspects of light-matter interactions (e.g. anisotropy, delocalization, and chirality) and its application for the realization of new plasmonic chemistry at the nanoscale. The expertise of the NANOPTO group and the top facilities available at the Institute of Materials Science of Barcelona and the proposed secondments at UCT Prague and LMU will be instrumental for my career development and constitute an important asset for my personal progression as a scientist. I will acquire new skills for the fabrication and characterization of macroscopic-scale plasmonic devices and extend my scientific network, and improve my mentoring expertise, with the final goal of securing seed funding for a stable group leader position.

Keywords: light matter interaction,strong coupling,rabi splitting,plasmonics,polaritonic chemistry,chemical soft lithography,colloidal chemistry
A SCORING SYSTEM FOR ONLINE CONTENT (Factmata)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Organisations (governments/brands) face major issues and are finding it increasingly difficult to tackle information warfare and emerging defamation threats on social media. Rumour mongering, false claims, and aggressively toxic opinions online have severe detrimental effects. Many policy and product launches are executed without granular awareness of how they might be received according to what stance the public is taking, and arguments the public is making in relation to a specific product/policy issue. Stock prices can also take a major hit. Many organisations (PR/Financial analysts/Governments/Agencies) use media analysis to monitor mentions of themselves online; however, current social listening and media monitoring tools are limited: they cannot perform sophisticated detection of key arguments and who is making them, and cannot thus identify useful influencers; they offer poor quality sentiment analysis via keyword detection which does not give insight as to the reason for sentiment, nor explain what rumour or claim caused it to change. Factmata aims to solve this challenge through development of an intelligent media analysis system that can detect and cluster claims, rumours, opinions, arguments, and stances in social media, news and blogs using natural language processing. Unlike current solutions which are limited by simple keyword analysis of media to provide tracking around sentiments, our solution provides algorithms and an interface that can detect, cluster and track claims, rumours, opinions, arguments and stances toward key topics (such as medical/clinical topics or political policy related topics). This enables PR campaign analysts to fully understand how public opinion is shifting on key policy discussions and thus optimise PR and social media messaging and also protect against negative rumours about their clients that can damage their reputation, which is a major risk in today’s “fake news” crisis with the rise of bot and troll networks online.

Keywords: disinformation,fake news,artificial intelligence,algorithms,content review,annotation system,media monitoring,natural language,media analysis,claim detection,harmful content
Age-related arterial dysfunction and gut dysbiosis in mice and cetaceans (Arterial Aging)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: SIGNED

Cardiovascular disease (CVD) is the number one cause of death in Europe. Arterial dysfunction develops with aging making advancing age the primary risk factor for CVD. Advancing age can induce adverse changes in the gut microbiome, which in turn, can activate systemic pro-oxidant and pro-inflammatory signaling pathways with detrimental downstream consequences. One main objective of this project is to investigate the role of the gut microbiome in modulating arterial function with aging. To approach this objective, I will carry out two experimental studies: 1) mouse-to mouse transplant of gut microbiota to investigate if gut microbiota transfers vascular phenotypes. This experiment will show if gut microbiota modulates arterial function with aging, and will provide insight into the mechanisms involved. 2) Germ-free mice with microbiota samples from human subjects to determine the contribution of the human microbiome to a particular phenotype. Cetaceans are long-lived mammals and excellent divers. They undergo constant cycles of tissue hypoxia-reoxygenation and shear stress caused by vascular adjustments while diving. In humans, these adjustments produce an elevation of oxidative stress and inflammation markers and impairment of the endothelial function. Thus, another main objective of this proposal is to explore if cetaceans, i.e. whales and dolphins, have developed an endothelium-protective mechanism to prevent arterial dysfunction with age and diving. To approach this objective I will study vascular function, circulating oxidative stress and inflammation markers, and gut microbiome of cetaceans of different ages in captivity as well as stranded animals. The objectives to investigate the role of the gut microbiome in modulating arterial function with aging will be carried during the first two years in the outgoing phase. This knowledge will be transfer to the host institution for the study of vascular function and gut microbiome in cetaceans of different ages.

Keywords: gut microbiota,arterial dysfunction,gut dysbiosis,arterial aging,germ free mice,cetaceans
Deployment of high pressure and temperature food processing for sustainable, safe and nutritious foods with fresh-like quality (HIPSTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Innovation actions
Countries involved: Germany,Spain,Ireland,Belgium,France,Netherlands,Netherlands
Call: Innovative solutions for sustainable novel food processing (H2020-SFS-2014-2, 2014)
Start date: 2015-03-01
End date: 2017-11-30
Duration (months): 33.0
Total project cost (EUR): 2332157.32
EU funding (EUR): 1978928.75
Participants: 9
Project status: CLOSED

High pressure and temperature (HPT) processing is a candidate technology for commercial food processing to obtain safer, high quality food products with extended shelf life, both chilled and shelf stable. Although it is accepted that HPT is environmentally friendly and can help to retain the fresh-like characteristics of foods better than conventional and other novel treatments, it has not yet been scaled-up and fully implemented into the food industry due to two major reasons: • The lack of knowledge on the inactivation mechanisms and decision making tools enabling food industry to apply and control suitable treatments. In addition, its added value (best quality product) compared to current treatments must be demonstrated • The unavailability of suitable industrial equipment and process parameters control tools. HIPSTER addresses the main barriers preventing the first market introduction and full deployment of HPT. The overall objective of the project is to develop and demonstrate fit for use knowledge, tools and industrial equipments in order to effectively implement this milder processing technology in the food industry. Specific objectives: - Development of affordable equipment at industrial scale suitable for the implementation of high pressure-temperature (HPT) processing - Definition of minimum process variables by means of the evaluation of microbiological risks for the main pathogenic and spoilage microorganisms of concern. A public database containing microbial kinetic parameters, determined under well-defined processing conditions will be generated. The database will include new knowledge and data already available. - Verification and validation of the solutions in an industrial environment, including compliance with legal requirements, economic feasibility, and sustainability HIPSTER will be implemented by an industry-driven consortium comprising 5 industries (both technology providers and end-users) and 4 RTD organisations.

Keywords: high pressure temperature food processing safety hpp hpt pats industrial equipment kinetics inactivation microorganisms spores pathogens tools monitoring sustainabilty water energy market deployment