Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
X-chromosome biology and immune health in females (XX-Health)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1998891.0
EU funding (EUR): 1998891.0
Participants: 1
Project status: SIGNED

Females have a higher risk for autoimmune disease and lower risk of mortality from infectious disease than males, reflecting a more robust immune response in females against both self-antigens (autoimmunity) and non-self-antigens (infections). Genes that escape the process of X-inactivation (XCI) are present in a higher dose in female cells and many play key roles in T-cell biology. XX-Health will reveal the role of escape genes in mediating sex-differences in T-cell response. Different cells in a tissue can inactivate the maternal (Xm) or paternal X-chromosome (Xp) (mosaicism). In addition, different ratios of Xm and Xp may become silenced in cells of a given tissue resulting in skewed X-inactivation (sXCI), rendering functional dissection of XCI very challenging. Rare females (~1:300) inactivate the same parental X-chromosome in all cells (cXCI), removing the confounding effect of mosaicism, and offering a powerful genetic system in which to dissect XCI in T-cell biology. We will develop a novel methodology, TriX-Seq, allowing high-resolution screening of sXCI and cXCI in a large (N~8,000) unselected cohort of females. Using T-cells isolated from identified cXCI females, we will (i) generate a unique multi-omic map of XCI during human T-cell differentiation at a resolution well beyond the state-of-the-art and (ii), directly test the function of alleles specifically expressed from the inactive X-chromosome (Xi) in T-cell biology. With sXCI data in hand, we will also reveal the associations, if any, of sXCI with disease risk and use the unique availability of parental and grand-parental DNA to assess the genetic origin of cXCI. Sex-bias in COVID-19 mortality has highlighted the importance of sex as a contributor to disease risk. The technical and conceptual advances delivered by XX-Health will make a seminal contribution to our understanding of this poorly understood component of human health.

Keywords: x inactivation,sex bias
Molecular Drivers of the InteractionS between marine algicidal KORdia and DIAtoms: from coexistence to algal lysis. (DISKORDIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-01-31
Duration (months): 19.0
Total project cost (EUR): 155099.28
EU funding (EUR): 155099.28
Participants: 1
Project status: CLOSED

Interactions between marine bacteria and phytoplankton are increasingly recognized as a fundamental shaping force of microbial taxonomic and functional diversity and activity. Algicidal bacteria, found in several marine taxa, possess the ability to induce cellular lysis in marine phytoplankton. Research on cultured strains shows a variety of algicidal properties on distinct phytoplankton host spectra among different bacterial taxa. These observations hint to the existence of an array of diverse but poorly characterized mechanisms implicated at various stages of bacterial-phytoplankton warfare: partner recognition, triggers of lytic activity, bacterial algicidal apparatus, and phytoplankton resistance tools. The research proposed in the DISKORDIA project – named after the Roman goddess of Strife Discordia – aims to provide a deeper understanding of the molecular aspects of the interactions between the algicidal marine bacterial genus Kordia and diatoms, a diverse and ecologically important phytoplankton group. Cutting edge techniques such as transcriptomics and untargeted metabolomics will be combined to enable naive discovery of genes and metabolites potentially involved in bacterial induction and effectors of algicidal activity, and in diatom sensitivity or resistance. In addition, genetic tools will be applied to a model Kordia strain to produce the first genetic system for algicidal bacteria in the Bacteroidetes phylum and test the role of specific bacterial genes in algal lysis. Finally, the ecological relevance of the processes identified by these methods will be explored at a global scale by bioinformatic screening of existing metagenomic and metatranscriptomic datasets from diverse marine environments. Together, these approaches will improve our understanding of the molecular strategies implicated in bacterial algicidal activity and phytoplankton response, while providing tools and a conceptual framework for future studies of microbial interactions.

Keywords: marine bacteria,marine diatoms,marine microbial interactions,algicidal bacteria,marine microbiology,transcriptomics,metabolomics
Hybrid-Electric Regional FUSelage & Empennages (HERFUSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Italy,Spain,Germany,Belgium,Greece,Portugal,Switzerland,Poland,France
Call: Innovative Fuselage/Empennage Design for Hybrid-Electric Regional Aircraft (HORIZON-JU-Clean-Aviation-2023-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 32989854.98
EU funding (EUR): 25726931.51
Participants: 32
Project status: SIGNED

The aim of HERFUSE proposal is to design innovative fuselage and empennages suitable for the future Hybrid-Electric Regional aircraft (HER) that will contribute to the overall target to reduce Green House Gases (GHG) emissions. HERFUSE will study the challenges on fuselage and empennages layout, material, components, manufacturing and assembly derived by integration of the relevant fuselage systems for HER as defined in the SRIA for a Hybrid-Electric Regional Aircraft and in HER-01 topic. HERFUSE integrates features and components necessary to regional hybrid-electric propulsion and complementary systems as well as improves weight, durability, aerodynamic efficiency and operational issues. The technologies and solutions matured in this project shall be aligned and feed with models, analyses and actual test data HERA project on regional aircraft (HORIZON-JU-CLEAN-AVIATION-2022-01-TRA-01). HERFUSE technologies, manufacturing and assembly of critical components will make feasible achieving the targeted performance gains of HER enablers such as low GHG energy sources (batteries and fuel cells), their storage (probable liquid in hydrogen case), their distribution and management, operational and safety features, thermal management provisions, electrical and thermal insulation. Technical solutions set by the HERFUSE will contribute then to the overall target and studies performed at aircraft level in HERA to reduce emissions. Namely, HERFUSE integration requirements will be concurrent and complementary to the aircraft-level ones set into HERA.

Keywords: fuselage,empennage,hybrid electric,aircraft,disruptive,hybrid electric propulsion,sustainable
Microbial sulfonolipid biosynthesis and degradation in the human gut (SLIDES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 214344.72
EU funding (EUR): 214344.72
Participants: 1
Project status: SIGNED

Sulfobacins are sulfonated lipids that are bacterially synthesized in the gut and modulate the immune system and dampen intestinal inflammation. Therefore, they are considered as potential therapeutics for targeted microbiome-oriented interventions in the increasing number of cases of inflammatory bowel disease. However, the effects of sulfobacins on the gut microbiota, the degradation processes, and the key enzymes of the microbial biosynthetic pathway are unknown. The complex human gut microbiota directly affects host health by influencing the abundance of metabolites, aiding in nutrient digestion, protecting against enteropathogens, and enhancing immune system activity. Dysbiosis is usually associated with disease and intestinal inflammation. It is a crucial prerequisite for microbiome-oriented interventions to elucidate the ecophysiology of the species that drive these pathways. The existence of sulfobacin decomposition has not been shown yet in any habitat but sulfonated lipid degradation is usually correlated with increased availability of reduced sulfur compounds, which can also act as signaling molecules. Thus, project SLIDES aims to discover the species and that drive the degradation in the human gut and the biosynthesis pathway. This will be accomplished by a combination of molecular biology and functional microbiome analysis methods. This will result in: (1) the elucidation of the sulfobacin biosynthesis pathway and its genes by reverse genetics, (2) the discovery of sulfobacin degraders and the impact of sulfobacins on the gut microbiota by monitoring the temporal dynamics of responsive taxa, metabolic activity, and metabolite changes in sulfobacin-stimulated human fecal microcosms, and (3) the description of ecophysiology of sulfobacin degrading species, the required genes, and the degradation metabolites produced using stable isotope tracing.

Keywords: gut,microbiota,sulfonolipids,sulfobacin,stable isotope tracing,lipid biosynthesis,lipid degradation,ecophysiology,fecal microcosm
Development of a high-throughput microplate based device to analyse the patient derived tumour microenvironment (3DTUMOUR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-02-01
End date: 2025-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cancer and tumours are exceptionally heterogeneous in tissue and cellular composition, clinical stage, and mutational status. Additionally, the presence of multiple cancers or metastatic tumours in patients leads to complicated drug regimens resulting in high off-target toxicity, unexpected drug resistance and difficulties in understanding the therapeutic effects. Despite a global investment in oncological drug development reaching 5 bn USD, less than 5% of all oncological drugs in the pipeline enter the therapy toolbox. Given the huge burden that cancer poses at all levels in society - leading cause of mortality worldwide, expected to reach 20 M deaths by 2050- technologies that enable pharmaceutical companies to increase the efficiency of drug development may alleviate the threat imposed to the more than 50 M people currently living with cancer. Such technologies include pre-clinical models that represent the tumour microenvironment and reveal the effect of drug candidates in laboratory tumour replicas. To provide clinically relevant information, such models must be patient specific and represent simultaneously the specificity of the target tissue and the cell heterogeneity of the tumour microenvironment. In addition, to be industrially relevant, they must be implementable, reproducible and high throughput. Commercially available solutions do not meet these requirements. 3DTUMOUR provides a proprietary technology to produce multiple 3D bioprinted replicas of patient-derived tumour models that faithfully represent the therapeutic target for a drug candidate. 3DTUMOUR aims at increasing the drug development success rate by transferring to industry this pharmaceutical testing platform. The successful outcome of this PoC will provide clinicians with a tool to test the efficacy of drugs ex vivo, accelerating the onset of efficient treatments and reducing off-target toxicity and unexpected drug resistance by applying a personalized-medicine approach.
Epigenome establishment and maintenance of the inactive X chromosome in response to DNA double-strand breaks in mammalian cells (XICUT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

The DNA damage response takes place on a chromatin substrate and triggers profound chromatin alterations. Chromatin states vary substantially between genomic regions, driving distinct gene expression profiles and also different DNA damage repair responses. One striking example is the heterochromatinization of an entire chromosome, the inactive X chromosome in female mammals, that is silenced during embryonic development by facultative heterochromatin formation. How the facultative heterochromatin state of the inactive X responds to DNA damage and impacts DNA repair is poorly understood. My research project aims at identifying chromatin changes that accompany the repair of the most cytotoxic form of DNA damage, DNA double-strand breaks (DSBs), in facultative heterochromatin and the mechanisms that ensure the establishment and maintenance of the inactive X chromosome in response to DNA damage in mammalian cells. To generate DSBs, I use the CRISPR/Cas9 technology that allows sequence-specific targeting of the Cas9 nuclease. Thanks to available bioinformatic tools, I can discriminate between active and inactive X chromosomes, analyze the genomic instability profiles induced around the break sites and decipher the repair pathway involved. In parallel, I will profile the chromatin marks associated with the inactive X chromosome in the vicinity of DSBs to assess the impact of DNA damage and repair on heterochromatin maintenance. Moreover, I will test the hypothesis that the high level of replicative stress-induced breaks in embryonic stem cells could drive heterochromatin establishment and thus skew the choice of the inactive X chromosome. For this, I will study the impact of generating DSBs on one X chromosome of mouse stem cells on their differentiation potential and their propension to inactivate the damaged X chromosome. Together, this work should shed light on the interplay between the DSB response and facultative heterochromatin states.

Keywords: x chromosome inactivation dna double strand break repair histone modifications histone variants chromatin organization cas9 microscopy cutandrun
A Territorial Construction System for a Circular Low-Carbon Built Environment (RECONSTRUCT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Spain,Netherlands,Italy,Greece,Belgium,United Kingdom
Call: Integrated solutions for circularity in buildings and the construction sector (HORIZON-CL6-2022-CIRCBIO-02-two-stage, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 6694967.5
EU funding (EUR): 5984641.01
Participants: 17
Project status: SIGNED

Globally, the Construction industry is responsible for over 30% of the extraction of natural resources, 25% of solid waste generated and 40% of Greenhouse Gases (GHG) emissions. Around a third of these emissions come from embodied carbon in construction. Cement and Steel are responsible for most of the embodied GHGs, representing >80% of the total. With recycling of cement and steel having a limited potential for further improving material efficiency, the focus is on replacing them with low-carbon alternatives and/or embedding them in reusable construction components. RECONSTRUCT will (i) develop low-carbon alternatives to Ordinary Portland Cement (OPC), to be used in both renovations and new buildings, and incorporate Construction & Demolition Waste (CDW) and other waste as much as possible, (ii) manufacture construction components that use such materials and are designed for modularity and dismantling so they can either be reused or easily disassembled and recycled, (iii) embed deconstruction in building design and construct circular low-carbon buildings that produce near-zero CDW across their lifecycle. These objectives will become possible through (i) the digitization of construction materials, products and buildings, (ii) the extensive use of digital tools to support the design, construction and deconstruction phases of the circular building and (iii) the regionalization of the construction value chain through the creation of regional ecosystems of stakeholders covering all the aspects of circular construction. The RECONSTRUCT concept will be demonstrated by setting up to Territorial Circular Clusters, in Brussels and Barcelona, and using RECONSTRUCT's materials, components and innovative tools to design and construct two real-scale demonstrator buildings. By doing so, RECONSTRUCT aims to demonstrate its high impact potential (including a GHG reduction potential of 137,12 Mt CO2 per year, avoidance of 85 million tonnes of CDW per year and substitution of 197 Mt of OPC concrete per year) and its economic feasibility.

Keywords: circular construction,urban industrial symbiosis,circular territorial cluster,circular building,alkali activated cement,textile reinforced recycled concrete,6d bim,digital product passport
Innovative concepts and technologies for ECOlogically sustainable NUTRIent management in agriculture aiming to prevent, mitigate and eliminate pollution in soils, water and air (ECONUTRI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Innovation actions
Countries involved: Greece,Spain,Germany,Italy,Portugal,Belgium,Netherlands,Poland,China,United Kingdom,Norway,Cyprus,Hungary
Call: EU-China international cooperation on nature-based solutions for nutrient management in agriculture (HORIZON-CL6-2022-ZEROPOLLUTION-01, 2022)
Start date: 2022-11-01
End date: 2026-04-30
Duration (months): 42.0
Total project cost (EUR): 5960650.54
EU funding (EUR): 5560916.25
Participants: 30
Project status: SIGNED

ECONUTRI is a consortium of scientific experts and researchers from different disciplines, private companies, farmers’ associations, and stakeholders. ECONUTRI is partnering with six Chinese Institutions, four from public research and two from industry, to complement activities and to strengthen the scientific collaboration between Europe and China. The project will scientifically support the EU’s Green Deal in its target to reduce fertiliser use by least 20% by 2030, thereby reducing by 50% losses of nutrients associated with negative environmental impacts. More specifically, ECONUTRI will address water pollution caused by NO3 and P leaching and run-off from cultivated soils, manure/slurry and plant residues, as well as greenhouse gas (N2O, CO2, CH4) and NH3 emissions from cultivated soils, barns, and organic biomass during storage, composting, and land application. ECONUTRI will optimise, validate, and demonstrate 24 innovative technologies that currently have a TRL of 4-6, and will increase their TRL to 7-8. These technologies are integrated parts of a holistic concept based on recycling of nutrients and organic material, novel machinery and fertilisers, novel decision support systems (DSS), and novel nutrient management plans incorporating nature-based solutions to reduce nutrient losses and to increase nutrient use efficiency. The expected results include hyperspectral analysis algorithms, advanced on-line DSS platforms to develop smart nutrient management plans for organic and conventional crops, protocols for circular cropping systems in open field and greenhouses, advanced emission monitoring feedback systems, novel manure spreaders, variable rate technologies for precision fertilisation, smart fertilisers, and biostimulants increasing N use efficiency. ECONUTRI will establish eight demonstration sites and deploy a comprehensive range of dissemination, communication, and exploitation activities to maximise the impact of the expected results and technologies.

Keywords: plant nutrition,nitrogen fertilisation,organic residues,organic agriculture,greenhouse gases,lca