Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting the human T cell response to pathogens, allergens, and self-antigens (PREDICT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Switzerland
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-07-01
End date: 2018-06-30
Duration (months): 60.0
Total project cost (EUR): 2495200.0
EU funding (EUR): 2495200.0
Participants: 1
Project status: CLOSED

The overall goal of this project is to test, in the human system, several hypotheses related to the role of T helper (Th) subsets in immunity and immunopathology. Using an experimental approach that takes advantage of high throughput culture methods and combines the ex vivo analysis of memory T cells with the in vitro priming of naïve T cells, we will dissect the Th cell response to pathogens, allergens, and self-antigens, in terms of antigen-specificity, tissue tropism, and cytokine production. We will identify signals and pathways triggered by microbes and allergens that prime polarized Th1, Th2, Th17 and Th22 cells as well as T cells with hybrid phenotypes producing, for instance, IFN-γ and IL-17 or IL-4 and IL-22. We will also address fundamental questions related to tolerance and autoimmunity by measuring frequency and distribution of self-reactive T cells in healthy donors and patients. The analysis of the response to microbes and allergens will address the possibility that different antigens, depending on abundance or location, may drive divergent Th cell responses, thus shedding light on the mechanisms of polarization and immunodominance in vivo. In pilot studies the project will also translate basic findings to the clinical setting, linking polarized Th responses to disease state and severity. Finally, using lentiviral-based approaches for gene silencing and overexpression, we will perform mechanistic studies to understand how environmental factors modulate in Th cells the production of pro- and anti-inflammatory cytokines. The hypotheses tested are strongly supported by preliminary observations from our own laboratory as well as from the biomedical literature. We expect that these studies will significantly expand our basic understanding of T cell biology and will have translational implications for the definition of correlates of protection or disease activity and for the design of improved vaccination and therapeutic strategies.

Keywords: autoimmunity allergy high throughput cellular screening assay
Multiparametric tumor imaging and beyond: Towards understanding in vivo signals (IMAGELINK)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Germany
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-06-01
End date: 2018-05-31
Duration (months): 60.0
Total project cost (EUR): 2494800.0
EU funding (EUR): 2494800.0
Participants: 1
Project status: CLOSED

Non-invasive preclinical and clinical imaging is a powerful tool and has a huge potential, specifically in the realm of oncology. Recently, our laboratory developed a novel multimodality imaging system, which combines positron emission tomography (PET) and magnetic resonance imaging (MRI), yielding temporally and spatially matched data. However, the molecular PET and functional MRI signals are very complex and are often not fully understood. Thus, we will cross-validate the complementary PET/MRI information with proteomics and metabolomics data to gain a better understanding of the in vivo image data and yield finally an accurate holistic tumor profile. The cross-validation will be supported by image-guided accurately dissected tumor substructures. Tumor metabolism, receptor status, hypoxia, perfusion, apoptosis and angiogenesis will be investigated by established PET tracers. In the same imaging session, functional parameters of the tumor, such as perfusion, oxygenation and morphology will be assessed by MRI. Beyond this, novel imaging ligands for senescence, tumor stroma, and fatty acid synthase, which have been recently recognized as emerging key-players in tumor progression and therapy resistance, will be developed. The individual in vivo and in vitro parameters will be fed into a data mining utilizing a computer learning approach with regression and classification methods to detect common patterns and the related pharmacokinetics behind the in vivo imaging parameters. Analysis of the dynamic PET data will be performed by compartment analysis and kinetic modelling. Overall aim is to gain a better understanding of imaging data, provide an accurate holistic in vivo tumor profile to support prognostic parameters for tumor progression and therapy response. Finally, the revealed information will lead to a more accurate selection of imaging biomarkers for diagnosis and therapy control and will provide input for new strategies in tumor-specific tracer development.

Keywords: imaging technology,data mining,oncology research,animal pet/mr,proteomics,metabolomics,pet tracer development,imaging probes
NUCLEAR REACTOR SAFETY SIMULATION PLATFORM (NURESAFE)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Reactor Systems
Action type: Collaborative project
Countries involved: France,Germany,Germany,Germany,Switzerland,France,Sweden,Italy,Spain,Belgium,Slovenia,Finland,Bulgaria,Czechia,Hungary,United Kingdom,Poland
Call:  (FP7-Fission-2012, 2012)
Start date: 2013-01-01
End date: 2015-12-31
Duration (months): 36.0
Total project cost (EUR): 9328144.31
EU funding (EUR): 5600000.0
Participants: 24
Project status: CLOSED

After the 2011 disaster that occurred in Japan, improvement of nuclear safety appears more clearly as a paramount condition for further development of nuclear industry. The NURESAFE project addresses engineering aspects of nuclear safety, especially those relative to design basis accidents (DBA). Although the Japanese event was a severe accident, in a process of defense-in-depth, prevention and control of DBA is obviously one of the priorities in the process of safety improvement. In this respect, the best simulation software are needed to justify the design of reactor protection systems and measures taken to prevent and control accidents. The NURESAFE project addresses safety of light water reactors which will represent the major part of fleets in the world along the whole 21st century. The first objective of NURESAFE is to deliver to European stakeholders a reliable software capacity usable for safety analysis needs and to develop a high level of expertise in the proper use of the most recent simulation tools. Nuclear reactor simulation tools are of course already widely used for this purpose but more accurate and predictive software including uncertainty assessment must allow to quantify the margins toward feared phenomena occurring during an accident and they must be able to model innovative and more complex design features. This software capacity will be based on the NURESIM simulation platform created during FP6 NURESIM project and developed during FP7 NURISP project which achieved its goal by making available an integrated set of software at the state of the art. The objectives under the work-program are to develop practical applications usable for safety analysis or operation and design and to expand the use of the NURESIM platform. Therefore, the NURESAFE project concentrates its activities on some safety relevant “situation targets”. The main outcome of NURESAFE will be the delivery of multiphysics and fully integrated applications.

Keywords: nuclear - light water reactors - safety - simulation
Optimal High-Lift Turbine Blade Aero-Mechanical Design (ITURB)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Italy,Italy
Call:  (SP1-JTI-CS-2012-01, 2012)
Start date: 2012-10-01
End date: 2015-06-30
Duration (months): 33.0
Total project cost (EUR): 839100.0
EU funding (EUR): 629325.0
Participants: 3
Project status: CLOSED

The need for high speed low pressure turbine modules to be used with innovative aircraft engine concept establishes critical mechanical constraints with very high hub stresses for the rotor blades, thus representing a real challenge for the design. In order to assist the designer with reliable tools it is mandatory to assess the performance of turbine rotor blades of innovative concept with both numerical and experimental investigations. Starting from a baseline configuration, representative of the state-of-the-art of LPT high-lift rotor blades, an aerodynamic optimization will be performed exploiting modern optimization techniques. These techniques are based on the coupling between fast and flexible parametric handling of the geometries, CFD computations and meta-models like Artificial Neural Networks (ANN) or Radial Basis Functions (RBF). Such an approach will accomplish a multi-objective design aimed at enhancing the aerodynamic performance while meeting mechanical and geometrical constraints. Tests will be performed on both baseline and optimized rotors within a cold-flow, large-scale laboratory turbine. Tests on turbine configuration will ensure the reproduction of the correct radial equilibrium effects as well as of the rotor-stator aerodynamic interaction. The Reynolds number will be investigated in the range between 50000 and 300000, which represents the operative range of the LP rotor blades of the engine. The large scale of the facility will allow detailed aerodynamic investigations, and an accurate performance analysis. The numerical and experimental frameworks will allow one to validate and verify the optimized solution and to highlight the key features of the new design with respect to the baseline. The validation of the design and optimization procedures will be accomplished with the availability of detailed experimental data obtained for the innovative rotor blade row in a realistic environment.

Keywords: innovative turbine rotor blades,aero-mechanical turbine blade optimization,turbine cold-flow experimental investigations
Advanced Flight control system – Design Development and Manufacturing of an Electro Mechanical Actuator with associated Electronic Control Unit and Dedicated test Bench (FLIGHT-EMA (E-RUDDER))

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain,Spain,Spain
Call:  (SP1-JTI-CS-2012-01, 2012)
Start date: 2013-03-07
End date: 2016-07-06
Duration (months): 40.0
Total project cost (EUR): 1151041.0
EU funding (EUR): 730613.5
Participants: 3
Project status: CLOSED

The FLIGHT-EMAFLIGHT-EMA project will design, develop, manufacture, tune and validate an innovative and smart Electro-Mechanical Flight Control system primary Actuator focused towards the study and validation of a future oil less Power by Wire aircraft. FLIGHT-EMA actuator will be based on a modular and efficient approach that will integrate easily exchangeable electric and mechanical components with sensors and control strategies that will allow automatic and autonomous safety control. The FLIGHT-EMA Electro-Mechanical Actuator will include its dedicated Electronic Control Unit, a Built In Test equipment to detect potential failures and a disable device to guarantee compatibility with emergency actuation. Different configurations will be studied and evaluated to determine the optimum system architecture from a technical point of view. Volume, mass, electrical consumption, power to mass ratio, reliability, durability and safety are concepts that will drive the development. The FLIGHT-EMA system will be tested and validated at several stages: Virtual validation at model level and finally actual experimental validations of the complete system through both on-ground and in-flight test campaigns. These sequential and complementary validations will assure thus a reliable, safe and efficient performance of the prototype and will provide data for a deep concept evaluation. For this validation purpose, the FLIGHT-EMA project will also design, manufacture and tune a Test Rig for FLIGHT-EMA Electro-Mechanical Actuator validation. FLIGHT-EMA Test Rig will allow installation both in Copper Bird® and in the ATR (Avions de Transport Regional) passenger cabin. The test bench will also include its own control system, inertia load simulation of the Rudder flight control surface involved weight and counter-load actuator with its hydraulic and electric power supply systems.

Keywords: flight control,ema,test bench
Greater Operating Temperature Alloy (GOTA)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Italy,United Kingdom,United Kingdom,United Kingdom
Call:  (SP1-JTI-CS-2012-01, 2012)
Start date: 2012-10-01
End date: 2016-04-30
Duration (months): 43.0
Total project cost (EUR): 796726.81
EU funding (EUR): 488252.5
Participants: 4
Project status: CLOSED

The objective of Greater Operating Temperature Alloy [GOTA] will be to select a titanium alloy capable of being fabricated into intermediate compressor casings, and enduring operating temperatures of at least 500 deg C in this service. Industrial manufacture of the selected alloy will be demonstrated, by the production of rolled rings; gravity cast and centrifugally cast samples; sheets, welding wire, and welded samples. • TIMET UK Ltd., [TIMET] will be the Principal Participant, and will lead the Management of the project. • Swansea University will lead the review of literature and prior industrial work. A candidate alloy (Ti+) will be selected based on this review, and on commercial and industrial factors. • TIMET will supply Ti+ billets to Forgital Italy S.p.A. which will manufacture, heat treat, and sample rolled rings. • TIMET will supply Ti+ casting stock to Deritend International, which will manufacture stepped section cast samples by both gravity and centrifugal casting, aiming to overcome the prior low ductility reported in castings of highly creep resistant titanium alloys. • TIMET will manufacture sheet; welding wire, and welded samples of the Ti+ alloy. Significant process development work is required in this task. • Swansea University will test the samples of the candidate to generate a database of mechanical properties for this titanium alloy in cast, wrought and welded forms and analyse the samples to rationalise the test results. • The tests will consist of tensile; creep; LCF; and fatigue crack propagation tests at both room temperature and 500 deg C. Also, tensile tests will be repeated after exposure to air at 500 deg C for extended time period, to check for deterioration in ductility. • TIMET UK Ltd., will lead the reporting of the project, and the Participants will disseminate the results through industrial meetings with potential end users (principally Volvo Aero and Rolls Royce) and through publications in academic journals and conferences.

Keywords: titanium,engines,operating,temperature,intercasing,alloys,forging,casting,icc,gota,cleansky
Optimal tooling system design for large composite parts (OPTOCOM)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain
Call:  (SP1-JTI-CS-2012-01, 2012)
Start date: 2012-12-01
End date: 2014-03-31
Duration (months): 16.0
Total project cost (EUR): 287740.0
EU funding (EUR): 215805.0
Participants: 1
Project status: CLOSED

The general objective of the project is to smartly handle the overall process of the composite integrated parts production reducing costs in two ways. First, by adequately simulating the spring back produced after the curing process and providing solutions in order to reduce the costs of reworking or assembly. Secondly, by simulating the thermal model of the set tooling/compositepart/vacuum bag and auxiliary parts under autoclave conditions to optimize the cure cycle temperatures distribution creating more uniformity in the composite part, lower residual stress, lower energy costs and better environmental friendliness. Given the large number of parts produced and their growth, the importance of the target is large. For that general purpose, the first specific objective of the OPTOCOM project is to carry out all the necessary steps to design and manufacture large tool for a composite complex structural part, typically a double curvature fuselage stiffened panel with co-cured stiffeners of about 2x1sqm. The stiffening elements shall be of both “Z” type and “Ω” type cross section. Requirements such as high accuracy and rigidity, typical autoclave conditions, CTE matching, durability, minimal weight, provisions for transport, handling and accessories integration for easy demoulding, shall be imposed Second, is to develop analytical and FEM models which adequately simulate the distortions and spring back occurring in the curing process. This requires to establish the correct hypothesis and to obtain real material performance behavior both along the curing process and when the composite is cured, in order to be introduced into the model. Third, is to set up FEM simulation models to assess the thermal behavior and temperature evolution of the set of elements that get in the autoclave in order to optimize the thermal ramps and maps in the composite part. Finally, an analysis of the design and manufacturing tooling costs to assess benefits and procedures is made

Keywords: large tool,composite parts,design,manufacture,double curvature,stiffeners,fuselage,accuracy,low thermal capacity,low cte,low weight,backstructure,durable,all provisions,mods&repair
What you get is what you see: How Reward Determines Perception (REWARDVIEW)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: The Human Mind and its complexity
Countries involved: Netherlands
Call:  (ERC-2012-ADG_20120411, 2012)
Start date: 2013-05-01
End date: 2018-04-30
Duration (months): 60.0
Total project cost (EUR): 2494525.0
EU funding (EUR): 2494525.0
Participants: 1
Project status: CLOSED

The expectation of a reward is known to be the driving force behind adaptive behaviour and learning. The effects of reward arise in dopaminergic reward circuitry at the centre of our primitive brain, which guides our goal-directed behaviour and fosters motivational control. A lot is known about the motivational effect of reward, but its effect on attention and perception has only marginally been explored. Recent studies from my lab suggest that such an effect of reward on perception is substantial and, crucially, arises instantly and is not related to a person’s motivation or strategy. Rewarding experiences change our brain: objects associated with reward appear to be more strongly represented in the visual cortex. This makes these objects to stand out from the environment. It makes that we perceive them, and focus on them, even when we try to ignore these objects. The research plan presented here will examine the neural response in early visual brain areas to objects associated with high versus low reward. We will measure the response of the brain, specifically the dopaminergic reward circuitry, when a reward is delivered. To investigate how these effects depend on dopamine, we plan to conduct studies involving Parkinson’s patients which allow us to directly manipulate the amount of dopamine in the brain. By means of deep brain stimulation, we link the effect even more tightly to the reward circuitry, by replacing reward by stimulation of this circuitry. As a final frontier we will relate individual reward sensitivity (a personality trait related to the mesolimbic dopamine system) to the development of addiction and risk seeking behaviour. The proposed research will have tremendous impact on the study of cognition, education, and (risky) decision making, as well as on a variety of clinical syndromes in which both attention and reward have been critically implicated, such as (drug) addiction and obesity.

Keywords: attention,perception,reward,brain response
Icephobic Coatings - Development of test methods (ICECODE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom
Call:  (SP1-JTI-CS-2012-01, 2012)
Start date: 2013-05-01
End date: 2014-12-31
Duration (months): 20.0
Total project cost (EUR): 348140.5
EU funding (EUR): 174000.0
Participants: 1
Project status: CLOSED

Icephobic coatings are being investigated as functional coatings for laminar flow. The coatings are intended to support the wing ice protection systems by reducing the formation or adhesion of ice and consequently reducing the energy requirements of the system. Currently, the most comprehensive method for measuring and understanding the icephobic nature of a coating is by performing icing wind tunnel tests. These tests require large dedicated wind tunnel facilities and would be too costly and impractical for production batch quality control and release testing purposes. For this reason a significant part of the research is dedicated to the development of suitable ‘bench top’ test methods that will allow accurate measurement of the icephobic nature of a coating, providing an indication of the long term icing performance of the tested surface. GKN intends to achieve this goal by determining the key contributing attributes to icephobicity of a surface and generating a predictive model, where predictions of performance can be derived from results of readily-available laboratory analytical techniques. This has not been achieved in entirety before and so to mitigate risk GKN will also attempt to develop in tandem a bench top ice adhesion test method which provides the same order of results as would be observed in an icing wind tunnel.

Keywords: adhesion,prediction,bench-top,icing wind tunnel,surface properties,coating,surfaces,freezing rain,run-back ice