Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enhancing Self-healing Properties in Polymer Materials through Cooperative Supramolecular Interactions (CoopHeal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The use of specific non-covalent interactions between molecular assemblies constitutes a general strategy to design a large variety of sophisticated materials. Functional supramolecular polymer materials have attracted the attention of scientists because of their multiple potential applications and their attractive improved properties, such as easy processing and recyclability. In this context, the main objective in CoopHeal is to introduce cooperative all-or-nothing interactions in supramolecular polymers. We will combine dinucleoside motifs able to strongly bind through multiple noncovalent interactions, with telechelic polymer chains that are flexible enough to facilitate recombination after damage. Our target material would be a thermoplastic polymer with optimal mechanical properties for easy processing and applied purposes, and with outstanding stimuli-responsive self-healing ability. The platform opens interesting opportunities for both the fundamental exploration of structure-property relationships and the design of technologically useful and economically viable materials. CoopHeal introduces fundamental challenges and unprecedented approaches in chemical self-assembly and constitutes the best research scenario for the MSC candidate, Dr. Anselmo del Prado Abellán, to learn from different fields across physical and polymer sciences and others to further develop his scientific career. The host Nanostructured Molecular Systems and Materials group at the Universidad Autónoma de Madrid (UAM), directed by Prof. David González-Rodríguez (DGR), is an active, emergent group, with a strong background in the topics of the proposal, and funded, among others, by ERC-granted projects.

Keywords: self assembled functional systems,noncovalent systems,polymer modification,stimuli responsive materials,self healing,supramolecular networks
In vivo fuel utilization and metabolic regulation by brown adipose tissue (GLUCOBAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 286921.92
EU funding (EUR): 286921.92
Participants: 2
Project status: SIGNED

Brown adipose tissue (BAT) has a high capacity to dissipate chemical energy generated from glucose and lipids as heat, a process typically induced by cold exposure, termed thermogenesis. This process has gained significant clinical interest as a strategy against obesity and diabetes because of its potential to expend excess calories as heat. However, our understanding of BAT metabolism on an organismal level is still rudimentary, thus, to advance BAT-targeted therapies, we must first comprehensively define how BAT utilizes its key fuels, such as glucose in vivo. It is widely assumed that the major role of glucose during thermogenesis is to provide energy for the TCA cycle and subsequent uncoupling by the key thermogenic protein in BAT, uncoupling protein 1 (UCP1). However, recent literature reveal that this assumption is oversimplified since glucose has many fates once it enters cells, feeding into additional metabolic pathways beyond the TCA cycle, which are necessary for optimum thermogenesis. In this project, I will use state-of-the-art glucose-tracing technology that utilizes mass spectrometry, combined with classic Cre-Lox and novel CRISPR/Cas9 genome editing strategies to precisely define how thermogenic adipose tissue utilizes glucose in vivo and to delineate the role of solute carrier transporters of the SCL family, including SLC25a1, for glucose utilization and thermogenesis. SLC25a1 delivers the glucose-derived metabolite citrate across the mitochondrial membrane for use in de novo lipid synthesis, a process that are highly regulated in the BAT of cold exposed mice. This project will expand our understanding of how thermogenic adipocytes utilize glucose and will potentially reveal novel therapeutic strategies to enhance thermogenesis. My previous experience with BAT metabolism and mass spectrometry-based isotopic tracing combined with the technological tools of my outgoing host and my host institute ideally poises me to successfully achieve my goals.

Keywords: brown adipose tissue,glucose metabolism,thermogenesis,solute carrier transporters
Towards a Self-Amplifying Carbon-Fixing Anabolic Cycle (CARBONFIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: CLOSED

How can simple molecules self-organize into a growing synthetic reaction network like biochemical metabolism? This proposal takes a novel synthesis-driven approach to the question by mimicking a central self-amplifying CO2-fixing biochemical reaction cycle known as the reductive tricarboxylic acid cycle. The intermediates of this cycle are the synthetic precursors to all major classes of biomolecules and are built from CO2, an anhydride and electrons from simple reducing agents. Based on the nature of the reactions in the cycle and the specific structural features of the intermediates that comprise it, we propose that the entire cycle may be enabled in a single reaction vessel with a surprisingly small number of simple, mutually compatible catalysts from the recent synthetic organic literature. However, since one of the required reactions does not yet have an efficient synthetic equivalent in the literature and since those that do have not yet been carried out sequentially in a single reaction vessel, we will first independently develop the new reaction and sequences before attempting to combine them into the entire cycle. The new reaction and sequences will be useful green synthetic methods in their own right. Most significantly, this endeavour could provide the first experimental evidence of an exciting new alternative model for early biochemical evolution that finally illuminates the origins and necessity of biochemistry’s core reactions.

Keywords: biomimetic synthetic methods,metabolism,co2 as feedstock,self amplification
Transcriptional regulation and mechanistic insights on the telomeric lncRNA TERRA (EnterTerra)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Telomeres, the heterochromatic structures that protect the ends of the chromosomes are transcribed into a novel class of long non-coding RNAs whose transcriptional regulation and functions are unknown. Telomeres protect the physical extremities of the chromosomes and they are are essential to genome integrity and stability. Dysfunctional telomeres have been detected in up to 90% of human cancers. We recently found that telomeres are transcribed from the subtelomeric region towards the end of the chromosome into the telomeric repeat-containing RNAs (TERRA). The identification of TERRA introduced a new field of research that demonstrates the structural and functional complexity unfolding at telomeres. Several lines of investigation have failed to elucidate the transcriptional activation network and functions of TERRA. The proposed research is built on a series of unrelated parts to explore the transcriptional requirements and the role of TERRA in the cells, employing a variety of different and revolutionary approaches. We plan to systematically identify the transcriptional factors that bind TERRA promoters and characterize their role in TERRA biogenesis (1). We will explore the dynamics of TERRA localization and determine if the transcripts remain attached to the sequence of origin or they can act at other chromosomal ends or loci (2). And finally we will elucidate the role of TERRA in stabilizing or recruiting telomeric or heterochromatic proteins at both telomeric and non-telomeric loci and assess their function on the chromatin (3). We expect that our innovative approaches will decipher TERRA’s localization preference on the chromatin, explore the multilayered ribonucleoprotein TERRA cluster, and it will provide new insights on plethora of telomere functions. Our studies will have a profound impact on our current understanding of the structural and functional complexity of telomeres.

Keywords: telomeres,subtelomeres,lncrna,terra,heterochromatin,telomerase,transcription factors,regulation,protein interactions
Integration of two-dimensional nanomaterials with functional oxide nanostructures (2DInterFOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

The integration of two-dimensional (2D) nanomaterials with non-2D nanostructures is of key technological importance in nanoelectronics and energy applications. Despite this, the atomistic understanding of 2D/non-2D interfacing is critically limited. In particular, functional non-2D metal-oxides need to seamlessly integrate with 2D materials (as e.g. dielectrics, barrier layers, charge transfer dopants or photo-catalysts) but to date 2D/non-2D oxide interfacing has not been addressed on an atomically resolved level. The project proposed here employs atomically-resolved, element-specific, aberration-corrected in-situ scanning transmission electron microscopy (STEM) techniques to elucidate the structural, chemical and electronic interactions of scalably chemical vapour deposited 2D nanomaterials (graphene, hexagonal boron nitride, molybdenum disulphide) with device-relevant non-2D metal-oxide nanostructures (e.g. Al2O3, HfO2, MoO3, TiO2). The project links realistic ex-situ 2D/non-2D oxide integration processes (evaporation, sputtering, atomic layer deposition) with dedicated in-situ STEM experiments and complementary spectroscopic fingerprinting (electron energy loss spectroscopy, x-ray photoelectron spectroscopy). It benefits from a unique combination of the applicant researcher’s extensive experience in in-situ characterisation of 2D materials and the applicant supervisor’s pioneering track record in STEM of 2D materials. The proposed work will establish a holistic picture of 2D/non-2D oxide interactions and thus provide critically required insights towards industrially scalable integration of 2D nanomaterials with non-2D nanostructures.

Keywords: aberration corrected scanning transmission electron microcopy,in situ,graphene,two dimensional nanomaterials,hexagonal boron nitride,chemical vapour deposition
Distributed Synthesis: from Single to Multiple Agents (D-SynMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Sweden,United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1871272.0
EU funding (EUR): 1716274.5
Participants: 2
Project status: SIGNED

Computing is changing from living on our desktops and in dedicated devices to being everywhere. In phones, sensors, appliances, and robots – computers (from now on devices) are everywhere and affecting all aspects of our lives. The techniques to make them safe and reliable are investigated and are starting to emerge and consolidate. However, these techniques enable devices to work in isolation or co-exist. We currently do not have techniques that enable development of real autonomous collaboration between devices. Such techniques will revolutionize all usage of devices and, as consequence, our lives. Manufacturing, supply chain, transportation, infrastructures, and earth- and space exploration would all transform using techniques that enable development of collaborating devices. When considering isolated (and co-existing) devices, reactive synthesis – automatic production of plans from high level specification – is emerging as a viable tool for the development of robots and reactive software. This is especially important in the context of safety-critical systems, where assurances are required and systems need to have guarantees on performance. The techniques that are developed today to support robust, assured, reliable, and adaptive devices rely on a major change in focus of reactive synthesis. The revolution of correct-by-construction systems from specifications is occurring and is being pushed forward. However, to take this approach forward to work also for real collaboration between devices the theoretical frameworks that will enable distributed synthesis are required. Such foundations will enable the correct-by-construction revolution to unleash its potential and allow a multiplicative increase of utility by cooperative computation. d-SynMA will take distributed synthesis to this new frontier by considering novel interaction and communication concepts that would create an adaptable framework of correct-by-construction application of collaborating devices.

Keywords: reactive synthesis,two player games,temporal logic
Connecting real estate agencies with worldwide investors (RealtyBundles)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Israel
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-09-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

RealtyBundles aims to be a global, online and liquid real estate trading platform connecting worldwide investors with local real estate agencies. The service we have defined is scalable, innovative with a clear business model beneficial to all stakeholders involved. The key novelties of the service is its ability to create new business model for existing small and medium real estate agencies (REA’s) allowing them to provide online trading services while meeting the needs of the investors. In addition, the RealtyBundles service is defining a novel concept of logical real-estate bundles formed of real properties, that provides investors a reduced costs and diversification while ensuring liquidity. The RealtyBundles service will provide a trusted & transparent service providing all the information and performance required for the investment.

Keywords: business model,crowdfunding,investment,real estate
Wafer-scale, CMOS integration of photonics, plasmonics and electronics devices for mass manufacturing 200Gb/s non-return-to-zero (NRZ) transceivers towards low-cost Terabit connectivity in Data Centers (plaCMOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Germany,Germany,Israel,Switzerland,Greece
Call: Photonics KET 2017 (H2020-ICT-2017-1, 2017)
Start date: 2017-12-01
End date: 2022-02-28
Duration (months): 51.0
Total project cost (EUR): 4036377.5
EU funding (EUR): 4036377.5
Participants: 8
Project status: CLOSED

The goal of the PlaCMOS project is to develop and demonstrate the next generation optical-electronic CMOS platform that will enable transceivers capable of real-time communication with data rates exceeding 200 Gb/s. To achieve this goal the PlaCMOS platform will be based on the latest bipolar CMOS (BiCMOS) technology and will be cointegrated with a ferroelectric plasmonic and SiGe detector technology. By exploiting plasmonics rather than photonics PlaCMOS will not only be able to extend the bandwidth far beyond 100 GHz but also reduce the footprint of the photonics device to the micrometer scale. To demonstrate the technology, a single channel 200 Gb/s non-return-to-zero (NRZ) transmitter and receiver pair will be implemented. To further show the scalability an ultra-compact 4 x 50 Gb/s transceiver directly interfacing a multicore optical fiber will be implemented and tested for temperature stability beyond 150 degree Celsius. And while the project goes far beyond the current state-of-the art, the approach is not speculative but is substantiated by recent experiments performed by the members of the consortium that indicate that both electronic and photonic limits can be stretched beyond the current limits. To this end a team with complementary skill sets from both industry and universities – all with outstanding track records in the field – have committed to address the needs outlined in current roadmaps for data communication. This project will demonstrate the capabilities of the technology for a single exemplary field of applications. Yet, the project has far wider implications with applications that go beyond the field of communications.

Keywords: 200 gbps,tranceivers,plasmonic modulators,bicmos technology,ferroelectric materials,wafer scale integration,monolithic integration,wavelength division multiplexing,space division multiplexing
Pandemic Risk and Emergency Management (PANDEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Coordination and support actions
Countries involved: Ireland,Belgium,Switzerland,Sweden,United Kingdom,United Kingdom
Call: Crisis management topic 4: Feasibility study for strengthening capacity-building for health and security protection in case of large-scale pandemics – Phase I Demo (H2020-DRS-2014, 2014)
Start date: 2015-09-01
End date: 2017-03-31
Duration (months): 19.0
Total project cost (EUR): 1384807.5
EU funding (EUR): 1277307.5
Participants: 7
Project status: CLOSED

The European Union (EU) faces a growing health security threat posed by pandemics due to the convergence of risk factors driving disease emergence, amplification and dissemination of pathogens with pandemic potential. Protecting the health and security of citizens in the EU in the face of these pandemic threats requires a coherent response by all stakeholders driven by effective pandemic risk management. PANDEM will contribute to the reduction in the health, socio-economic and security consequences of future pandemics so that society will be better prepared at regional, national, EU and global level. PANDEM will assess current pandemic preparedness and response tools, systems and practice at national, EU and global level in priority areas including risk assessment and surveillance, communication and public information, governance and legal frameworks. PANDEM will then identify gaps and improvement needs leading to the development of viable innovative concepts and analysis of the feasibility of a future demonstration project to strengthen capacity-building for pandemic risk management in the EU. PANDEM specifically addresses the needs and priorities detailed in the Horizon 2020 Work Programme crisis management topic DRS-4. PANDEM will focus on the needs and requirements of users and first responders across the spectrum of pandemic risk management. PANDEM will bring together highly skilled and multi-disciplinary senior experts from the health, security, defence, microbiology, communications, information technology and emergency management fields. Given the cross-border and multi-sectoral context of the health and security challenge for building pandemic risk management capacity, a systems-based methodology will be applied and the final outcome will be developed for use in a pan-European setting.

Keywords: emerging disease,risk assessment,surveillance,communication,education,health security,large scale pandemics
Space hUbs Network (SUN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Coordination and support actions
Countries involved: Austria,Austria,Ireland,Lithuania,Poland,Romania,France,United Kingdom
Call: Space hubs (support to start-ups) (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2023-03-31
Duration (months): 27.0
Total project cost (EUR): 998031.25
EU funding (EUR): 998031.25
Participants: 8
Project status: SIGNED

SUN (Space hUb Network) aims to increase the commercialization of space enabled solutions and growth of European start-ups and scale-ups in space downstream and upstream sectors by implementing a multi-dimensional concept. To increase the number of space applications being developed as well as involve SMEs into space sector, project will organize 4 Hackathons (at least 200 participants) and 9 Roadshow events for SMEs (attended by 480 stakeholders). In order to complement (instead of competing) existing European initiatives, these events will target stakeholders of specific industries that can mostly benefit from space technologies, for example, telecom, mobility, agriculture. Space entrepreneurs (at pre-startup stage), start-ups and scale-ups will receive an opportunity to participate in mentorship programme. SUN will be implementing 3 types of mentorship programmes based on the IRL & TRL level of each participant. In total, 80 start-ups and scale-ups will participate in mentorship programmes. Main goal of it will be to help startups advance their IRL and get access to finance. SUN will also conduct extensive ecosystem mapping and will aim to build bridges among current local and international initiatives supporting space start-ups and scale-ups. SUN will complement the initiatives by matching them with space entrepreneurs. Consortium has been formed to involve organizations specializing in space technologies and applications, incubation and business support, technical support, start-ups and community building. Project activities will take place in 6 countries (Austria, Ireland, France, Lithuania, Poland, Romania) but will target start-ups and scale-ups on pan-European level.

Keywords: start up,scale up,acceleration,mentorship,hackathon,investment readiness level,ecosystem building