Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Islamic architecture and Orientalizing style in Habsburg Bosnia, 1878-1918 (THEKAISERSMOSQUES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Austria
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1257973.0
EU funding (EUR): 1257973.0
Participants: 1
Project status: SIGNED

The project highlights a grossly understudied experiment at the intersection of nineteenth-century European and Islamic architectural histories. It draws attention to a significant body of buildings designed by architects trained in Central Europe for use by Muslims in Habsburg-ruled Bosnia-Herzegovina (1878-1918). These buildings, many of which mosques, largely draw upon a traditional Islamic formal and functional typology. The composition and decoration of their facades, however, is the product of nineteenth-century Historicist conduct. Quoted are elements from assorted Islamic artistic heritages, with prominence given to Cairo and Andalusia. In Bosnia, many of these buildings were misinterpreted as mere renovations of Ottoman edifices, as is indeed declared on several inscriptions. However, this information generally appears to pertain to the institutions accommodated in these buildings rather than to their present form and architecture. The project’s primary intention is to validate the assertion that these buildings must be considered a distinct group of architectural monuments, and that they, in consequence, constitute a phenomenon that necessitates separate appraisal and study. Intertwined with this architectural phenomenon is the stylistic phenomenon traditionally (yet inaccurately) called ‘pseudo-Moorish’ in Bosnia. This Orientalizing style was the preferred choice for buildings constructed for use by Muslims; it is be the project’s second focus of inquiry. The study seeks to explore its historical sources and the channels of their reception, as well as the logic and aesthetic of these sources’ paraphrasing in a nineteenth-century context. By documenting and analyzing this heritage in the necessary detail, the project fills a significant gap in published scholarly research. It also contributes to our understanding of European powers’ historical responses to the challenge of cultural diversity in territories under their control.

Keywords: orientalism,architectural history,islamic art,southeast europe,balkans,central europe,austria hungary,bosnia herzegovina
Effective and Affordable Flu Vaccines for the World (INDIGO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: India,Italy,Belgium,France,France,France,Netherlands,United States,Netherlands,Netherlands,Denmark
Call: Towards a next generation influenza vaccine to protect citizens worldwide – an EU-India collaboration (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 16000968.0
EU funding (EUR): 9975979.0
Participants: 18
Project status: SIGNED

Despite the availability of flu vaccines for decades, influenza is still an important disease in both developing and developed countries with 500,000 casualties annually and many more people affected. From a global health perspective, the lack of effectivity, availability, affordability and accessibility of flu vaccines significantly limits our ability to respond to the seasonal flu every year and in the event of a pandemic. Currently, a low vaccine effectivity of 40% implies that 60% of vaccinated people are not sufficiently protected, with low confidence further contributing to limited uptake/immunization. In this project, public and private R&D organizations in India, EU and US collaborate on the development of two novel influenza vaccine concepts that meet the requirements of global vaccination, aiming to achieve <10% instead of 60% non-responders, lower costs, and better accessibility. The first approach combines a low dose of a commercial, inactivated, seasonal flu vaccine with a novel, potent adjuvant, and will deliver proof-of-concept in Phase I and IIa trials within 5 years. The second approach builds on three innovations: 1) a novel recombinant HA with increased immunogenicity, 2) a potent adjuvant, and 3) an easy, needle-free delivery by intradermal patches. Contra-productive parts of HA will be removed to increase the immunogenicity of neutralizing epitopes. The adjuvant further stimulates protective immunity and immunological memory. The use of intradermal patches opens possibilities for self-administration, which will improve vaccine uptake in developing as well as developed countries. With proven nonclinical immunogenicity and safety, we will embark on clinical development of this concept after completion of the project. These plans differ in complexity and timelines but are realistic with chances to deliver next-generation flu vaccines for the globe.

Keywords: influenza virus vaccine,adjuvants,needle free,intradermal patches,recombinant ha,ha deletion mutants,t reg epitopes,microneedle patches
Contain, Distribute, Obstruct. Governing the Mobility of Asylum Seekers in the European Union (CONDISOBS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Luxembourg
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-15
End date: 2022-01-14
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

CONDISOBS aims to strengthen the professional profile of the researcher through the design, management and implementation of an individual research project, as well as through advanced training in research methods and transferable skills. The project will provide a unique and comprehensive analysis of the three key measures that were undertaken after the “refugee crisis” to govern asylum seekers’ mobility in the EU, which is to say hotspots, relocation, and border controls. More specifically, it aims to understand whether hotspots have succeeded in containing incoming migrants in the first country of entry and whether relocation schemes and the strengthening of border controls have reduced “secondary movements” of asylum seekers within the EU. This will be achieved through an extensive, multi-sited qualitative study focusing on three aspects. The first concerns the functioning of hotspots in Greece and Italy and their ability to register all incoming migrants and channel them to the relevant administrative procedure. The second relates to the practical difficulties encountered by Greek and Italian authorities to relocate people, as well as the trajectories of those who were relocated to Luxembourg and Lithuania. The third deals with the effects of the reintroduction of border controls in three strategic border points that are commonly used by migrants to leave Italy (Bardonecchia, Brenner, and Ventimiglia). With its findings, the study will contribute to current debates on the reform of the Common European Asylum System by providing policy recommendations based on solid empirical evidence, which will be communicated through a comprehensive dissemination plan targeting both academic and non-academic audiences. Thanks to its manifold focus on research, training, project management and dissemination, CONDISOBS will thus represent a key stage in the career of the researcher, while also broadening the research base and networking opportunities of the host institution.

Keywords: critical migration studies,eu asylum regime,hotspots,relocation,dublin regulation
Ecological Sensitivity Distribution (ESD): integrating molecular-based structural and functional microbial community responses in a new tool for environmental risk assessment of chemicals (MicroERA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Aquatic ecosystems are regularly threatened by chemical mixtures. Among risk assessment methods, the Species Sensitivity Distributions (SSD) approach is frequently applied. SSDs are built on the sensitivity of species, obtained from monospecies bioassays, and aim to derive concentrations expected to protect the structure of field communities to chemicals. However, this method overlook species interactions and the protection of ecosystem functions. Microbial communities constitute a key compartment of aquatic ecosystems since they support bio-geochemical processes that are crucial for their proper functioning. Thus, their protection to chemical-induced hazards is a crucial challenge for a sustainable management of ecosystems. Until now, these communities were weakly focused by the regulatory risk assessment guidances. The main aim of this study is to further develop the SSD approach to a new risk assessment tool, the Ecological Sensitivity Distribution (ESD), (1) adapted to microbial communities, (2) protective for structure and functions and (3) integrating species interactions. Integrating community functions in risk assessment approaches is a real need for scientific, regulator and industrial sectors since the protection of ecosystem services (whose proxies are functions) is at the very heart of the environmental policies of European member states (REACH regulation, Water Framework Directive). This tool will be based on the sensitivity of many endpoints related to structure and function including molecular endpoints measured at the microbial community level in “cosms”. Hence, another innovative aspect of this project is the inclusion of OMICs-technologies to environmental risk assessment, through both targeted approaches (focus on genes coding for specific functions) and untargeted ones (metabolomics). The reliability of the ESD-approach will finally be assessed at a large scale in key European aquatic ecosystems with the support of the European Biofilm Network.

Keywords: risk assessment,ecotoxicology,aquatic ecosystems,microbial communities,functions,omics,modelling
Cost-effective High-efficiency Smart Steam Boiler of Low Emission technology (ECOVAPOR)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Italy,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 1991926.25
EU funding (EUR): 1425098.38
Participants: 4
Project status: CLOSED

With EcoVapor, we offer a smart steam boiler that will make steam production a very cost-effective (ca. 30-50% cheaper than typical 3-pass boilers of low NOx emissions), energy-efficient (up to 95% overall), smart (custom-designed based on specific needs for the industry which operates at different powers within a large modulation range (5-100%)), and environmentally friendly alternative (only 80mgNOx/kWh emissions able to comply with the most stringent regulations) to appeal to market segments that want to foster the uptake of new steam-generating technologies to reduce energy bills, optimise energy consumption, and reduce NOx emissions. Our company, ICI Caldaie, has partnered with Burnertech - a UK based engineering company specialised in design and manufacturing of tailored solutions for burner design – Troll System - an Italian company with more than 20 years expertise in custom-designed products of the electronic market - and CTIC-CITA - a Spanish cluster of companies of the F&B sector, to exploit €69.44 million accumulated revenues (by 2022) business opportunity. EcoVapor has been developed integrating a low NOx pre-mix burner developed by ICI based on the combustion head of Burnertech (patent application: WO2014167270 (A1)), and an e-term® PCB control electronics from Troll. We plan to penetrate initially the EU F&B industry by mid-2018 in countries coinciding with ICI highest volume of sales (Italy, Spain, UK, France, Poland, and Romania), and then, other industries starting from 2019 (i.e. textile, tanning, chemical, and pharmaceutical) in EU and non-EU countries we already have a consolidated presence (Serbia, Ukraine, Russia, and Kazakhstan) along with US and Canada by 2020, through direct contact of our current sales force.

Keywords: steam,boiler,food and beverage,nox emissions,firetube boiler,reverse flame,pre mix burner,inward flame,control electronics,power modulation,energy efficiency
Feasibility assessment on sustainable bulk products, made from coconut fibers (CCP)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Netherlands
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the worldwide transport sector, there is a huge demand for (mainly wooden) pallets. Although these pallets meet their functional requirements, they have an enormous effect on the environment, by leading to deforestation, extra transport costs for wood import, and energy and chemical usage in certification. The goal of the CCP project is to use a resource that is currently considered waste, as the basis for a sustainable, organic pallet, thereby also contributing to a circular economy. The resource is husk from coconuts, hence the project name: CoCoPallet. With a worldwide production of over 62 billion coconuts, there is more than enough material available. In cooperation with the Wageningen University and Research Centre, an innovative and revolutionary production process where both a fiber and resin (lignin) are sourced from the same material (the husk) has been found, to produce the pallets, by pressing the material into 2D and 3D shapes. By using the waste of the coconuts, a health risk is also minimized, as the current coconut husk waste ends up in the sea or on landfills. In the latter, it is a hotbed for malaria mosquitos and thus a large regional biohazard. Specific objectives in this CoCoPallet H2020-SMEINST Phase 1 study proposal are: - Explore at least 5 (up to 10) promising business cases and value chains for a variety of applications for pressed coconut fiber material, including transport pallets. - Evaluate the required specifications and characteristics of these applications with potential customers. - Elaborate on a detailed business plan. By sourcing locally, transport costs for the material are also reduced dramatically. The company already has contact with local suppliers and organizations, as a first step to get to know the market better and scale up its business.

Keywords: coconuts,lignin,circular economy,sustainability,production process
Standard And Modular Microlauncher BAsed services (SAMMBA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Belgium,France,France
Call: Access to space (H2020-SPACE-2019, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 2529897.5
EU funding (EUR): 2529897.5
Participants: 8
Project status: SIGNED

The spaceports target to attract to their business case multiple microlaunch concepts available in the market, while microlaunch concepts look forward to launching from multiple spaceports seeking a launch rate at a wider range of azimuths that enable their business plan goals. SAMMBA objective is to develop base services that provide cost-effective, agile and flexible launch campaigns, empowering spaceports to operate multiple launch concepts while fitting in the cost and the launch rate targeted in the payload market. That goal is tackled through two main axes: the base services design through model engineering systems and the implantation of innovative 4.0 technologies. That approach provides standard and modular base services with the capability of being instantiated at several spaceports, opening launch concepts to a multi-spaceport scenario. SAMMBA main outcome is the deployment of technologies and demonstrators at microlauncher spaceports on the Advisory Board. As a result, SAMMBA contributes to major goal of increasing European competitiveness in access to space, allowing European Spaceports to offer affordable ground services competing technological and economical for the launch services and payload market.

Keywords: microlauncher,modular,standard,based services,cost effective,flexibility,industry 4 0,space port,launch pad
Effects of rewiring microexons (REMIX) on tissue-specific signaling networks (REMIX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-06-20
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Signaling networks control a vast range of complex cellular behaviors. The wiring of these networks varies greatly from one cell type to another in the body, depending on the specific functions required of different tissues. However, the mechanisms controlling the tissue-specific wiring of signaling networks are poorly understood. Kinases play a major role in directing signal flow by interacting with and phosphorylating specific target proteins. Interestingly, recent studies on the tissue-specific alternative splicing of very small exons called microexons found an enrichment of these microexons in kinases. This raised the question of whether microexons might occur in regions of kinases mediating specific kinase-substrate interactions. Theoretically, such “rewiring microexons” could contribute to the differential regulation of signaling networks in different cellular contexts. Furthermore, their dysregulation could potentially lead to pathogenic signaling in diseases such as cancer. Accordingly, the proposed research will address the questions: What role do microexons play in regulating kinase substrate specificity and tissue-specific wiring of signaling networks, and what are their potential roles in cancer cell signaling? To answer these questions, I will (1) experimentally determine the substrate specificities of kinases with/without microexons, (2) demonstrate the ability of the candidate microexons to rewire cellular signaling networks, and (3) investigate the dysregulation of kinase microexons in cancer using bioinformatics. This multidisciplinary study will fill a gap in our understanding of the functional roles of microexons in regulating kinase substrate specificity, and help to unravel the mechanisms underlying the immense variation of signaling activities between different cell types both in health and disease.

Keywords: signaling networks,kinase,substrates,determinants of specificity,alternative splicing,microexons,cancer
The historical-revolutionary museums of Petrograd-Leningrad, 1917–1941 (REVMUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-16
End date: 2024-07-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

This project will analyse the formation of memory about the nineteenth-century revolutionary movement in Russia and the 1917 Revolution in a group of historical-revolutionary museums in Petrograd-Leningrad between 1917 and 1941. The two decades after the October Revolution witnessed a transformation of the memory landscape, as Bolshevik leaders exploited the struggle to overthrow the old regime as an instrument of political legitimacy. The scholarship has dealt extensively with the management of the revolutionary narrative from the top; however, key institutions involved in the governance of the recent past, particularly, museums, remain understudied. This pioneering study of museums will provide a unique view of how memory was shaped on the ground. Petrograd-Leningrad is chosen for the analysis due to its status in the Soviet memory politics – that of ‘the city of three revolutions’ and ‘the city of Lenin’. The historical-revolutionary museums explored here include the House Museum for the Memory of Freedom Fighters, the State Museum of the Revolution – GMR, the Museum of Sergei Kirov, the Museum of Lenin in Leningrad, and a handful of smaller, short-lived museums such as the Museum of Komsomol and the Museum of the Army and the Fleet. While scholarship claims that the Soviet state was steady in imposing the ‘Bolshevik-centred’ memory project from 1917 on, I will show how a clash of seeming similar, yet different memory projects unfolded in all these museums. The House-Museum and the GMR operated with a broad concept of the ‘revolutionary movement’ that included all the antimonarchist political forces that had been active in the Russian Empire, not just the Bolsheviks. This project withered only in the early 1930s ceding way to the ‘Bolshevik-centred’ and then ‘Lenin/Stalin-centred’ ones that emphasized the role of the Communist party and mythologized figures of Lenin and Stalin in designing the 1917 revolution – to the detriment of all other participants.

Keywords: stalinism,counter revolution,soviet history,soviet society,memory politics,history of leningrad,russian revolution,generations