Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structure guided inhibition of IDOL to treat atherosclerosis and the metabolic syndrome (CHANCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-10-01
End date: 2022-03-31
Duration (months): 30.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The prevalence of the MetS and associated co-morbidities including cardiovascular disease has reached epidemic proportions in the developed and developing world. The cost of treating these conditions represents a substantial part of current European healthcare expenditure, and despite recent advances, treatments for MetS-associated lipid disorders are far from optimal; mainstay lipid-lowering treatments (e.g. statins) reduce cardiovascular risk by only ~30%, and recently-introduced PCSK9 inhibitors are promising, but prohibitively expensive. Moreover, epidemiologic and genetic evidence suggests that these treatment modalities are associated with a significant increase in the risk for development of diabetes. Treatments for other MetS-associated comorbidities, including dyslipidemia, diabetes, obesity, and fatty-liver disease are far from optimal or lacking. In ERC-CoG UNICOM we discovered that genetic inhibition of the E3-ubiquitin ligase IDOL protects mice from the detrimental development of multiple MetS-associated comorbidities. We therefore propose IDOL inhibition as a novel therapeutic strategy to concomitantly target multiple metabolic co-morbidities. However, absence of a high resolution IDOL structure has hampered structure-guided development of inhibitors. In CHANCE, we will capitalize on the high resolution 3D structure of IDOL that we recently obtained. Using this unique structure we aim to identify and validate small-molecule IDOL inhibitors by using a structure-guided development pipeline that combines an established virtual ligand docking protocol, and in vitro and in vivo validation. Lead hits will be used for development of a business and IP strategy to ensure the sustainable development of IDOL inhibitors for treating the MetS.

Keywords: metabolic syndrome,idol,lipid metabolism,structure guided drug development,virtual ligand docking
Practices of Climate Diplomacy and Uneven Policy Responses on Climate Change on Human Mobility (CLIMACY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-09-16
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

Climate change is a concern for states both at home and abroad. However, disparities often exist between the picture painted by climate diplomacy and domestic policy measures, be it in the level of priority afforded to climate action, or the integration of climate concerns across policy silos. A key area of work for climate diplomacy is human mobility in the context of climate change, which brings into stark relief the cross-border reach of climate change impacts and is billed as one of the biggest societal challenges of climate change. Much of the focus until now has been on the vulnerabilities and resilience of individuals, communities, and states in the Global South most likely to be affected. However, little is known about the political sphere and the climate diplomatic practices of states in the Global North in relation to climate change and human mobility, and in turn how these diplomatic efforts tally with domestic climate action. This project therefore asks the following question: How are nation-states developing practices of international climate diplomacy in relation to climate change and human mobility and to what extent do these align or discord with their practices at the state level? This question will be answered with a comparative case study of five European nation-states. In the first work package, the international climate diplomacy practices of these states will be examined, with the second work package concentrating on domestic policymaking. In the third and fourth work packages within-case and cross-case comparisons will be undertaken respectively, to ascertain whether practices at the international level align or discord with practices at the state level and to compare these findings across cases. The fifth work package will conduct a critical analysis of the findings to feed into conceptual and political debates on climate change and human mobility.

Keywords: climate change,politics,policy,human mobility,austria,germany,denmark,sweden,norway
Passive Isolation Condenser (PIACE)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Innovation in nuclear safety
Action type: Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Italy,Belgium,Slovenia,Romania,Slovenia
Call: Encouraging innovation in nuclear safety for the benefit of European citizen (NFRP-2018, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 3210439.81
EU funding (EUR): 2247229.76
Participants: 12
Project status: CLOSED

PIACE has the main objective to support the technology transfer from the research to industry in the area of safety of nuclear installations. An Innovative Decay Heat Removal System for nuclear reactors, presently under technology validation in relevant environment (SIRIO facility), will be scaled-up to achieve a system prototype demonstration in operational environment, relevant for LFRs/ADSs and LWRs.

Keywords: nuclear safety,passive isolate
DEMOnStrators of micro waves efficiency for agrifood industry (DEMOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain,France,France
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2017-09-30
Duration (months): 30.0
Total project cost (EUR): 2441377.5
EU funding (EUR): 1708964.25
Participants: 3
Project status: CLOSED

Vegetable proteins are more than ever an issue for future generations. Unfortunately, today’s Europe suffers from severe chronic dependence on protein imports from the American continent. Significant works are therefore underway among the industry’s manufacturers to reduce dependence and to develop products for human consumption based on vegetable proteins with superior characteristics. Process improvements are sought in this context in order to increase, in a cost-effective manner, and with a minimised environmental and energy footprint, the extraction of soluble and/or native proteins while providing better control of their physiological and functional properties (digestibility, allergenicity, bioactivity, organoleptic characteristics...). Because it can generate a given amount of electromagnetic energy at a given frequency, and in accordance with propagation rules that are managed and controlled in a very precise and dynamic manner, depending on the food process involved and the electromagnetic absorption capacities of the plant resources to be treated, the DEMOS microwave equipment, developed by 3 industry-leading SMEs, paves the way for such process innovation! To access the markets, the three DEMOS SMEs must demonstrate the industrial reality of their first prototypes by upscaling them into a completely industrial microwave treatment equipment capable of continuously processing several dozens of tonnes per hour while ensuring better recovery of vegetable proteins and making energy and chemical savings of 30% compared to the processes of extraction, steaming or conventional chemical treatments.

Keywords: microwave processing,oilseed crushing,debacterisation
A Gaming and Social Network Platform for Evolving Energy Markets’ Operation and Educating Virtual Energy Communities (SOCIALENERGY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Cyprus,Bulgaria,Greece
Call: Gaming and gamification (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-06-30
Duration (months): 30.0
Total project cost (EUR): 1218125.0
EU funding (EUR): 998000.0
Participants: 4
Project status: CLOSED

Technology transfer of gaming assets to non-leisure contexts such as the energy efficiency sector has become the “holy grail” of today’s research and industrial efforts towards a more sustainable energy system. The main objective of SOCIALENERGY is to develop, validate and demonstrate a gaming and social network platform for educating energy consumers and virtual energy communities towards evolving EU energy markets’ operation. In SOCIALENERGY’s virtual world, users are seamlessly educated via advanced gaming techniques in good practices and decision making related with energy efficiency. Subsequently, users are able to interact in SOCIALENERGY’s “real-world” platform, which will facilitate the easy, rich and deep communication among involved stakeholders from individual energy consumers and virtual energy communities, to utilities, policy makers, and even other indirect stakeholders (such as electric appliance retailers and building renovators) that will allow them to: i) discover each other, ii) educate themselves in order understand the difficulties and challenges that each one faces and iii) finally interact and trade among. SOCIALENERGY aims at undertaking innovation actions to: a) apply and evolve recent incentive technologies (localized social externalities) towards effective use of behavioural economics in energy efficiency sector, b) educate and effectively incentivize utility customers via advanced gaming and gamification technologies, c) guarantee efficient and sustainable user engagement via self-organization and management of virtual energy communities, d) provide a single point of hosting and advertisement services to consumers, utilities and companies related with energy efficiency products and services, e) perform real-life small-scale but diverse experiments to validate proposed platform’s functionalities, f) provide energy information distribution as a service to interested stakeholders.

Keywords: green social network,virtual energy communities,virtual world,demand response,energy market
Clinical Validation of a Novel Biomarker for the Prediction of Bone Metastasis in Early Stage Breast and Prostate Cancer (OSTEOMET)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

OSTEOMET is a new and proprietary test based on IHC and FISH technologies that addresses the unmet medical need of selecting patients at risk of bone metastasis in breast and prostate cancer. OSTEOMET is based on an innovative single biomarker whose expression levels in primary tumour tissue are highly associated to bone metastasis. OSTEOMET will lead to an improvement in clinical practice, improved prognosis and personalized therapy of patients with breast and prostate cancer, with a large positive impact on the economic efficiency of health care operators. The OSTEOMET project has previously been evaluated as a stage 2 project, reaching the threshold on each criterion (> 4/5). We now have decided to take one step back to address existing gaps via a phase 1 proposal. Since the clinical utility of OSTEOMET will depend on the outcome of the clinical validation studies, we envision a number of scenarios for positioning OSTEOMET in the market. This phase 1 proposal will deliver a clear roadmap for achieving the commercialization of OSTEOMET in either of the different scenarios. We will perform expert interviews and map out various aspects including the clinical validation track, the regulatory path, target user specifications, an assessment of the EU and US market and reimbursement environment and a strategic approach to drive clinician adoption and payer acceptance to optimize market penetration. Our elaborated business plan will include a strategy to establish partnerships with Diagnostic or Pharma companies as well as the value created for Inbiomotion in each scenario. We trust that the current project will fill in the gaps supporting the business feasibility of marketing OSTEOMET as a new diagnostic kit

Keywords: prognostic,predictive biomarker of bone metastasis,breast cancer,prostate cancer
World Manufacturing Forum 2018 (WMF2018)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Coordination and support actions
Countries involved: Italy
Call: Presidency events (H2020-NMBP-CSA-2017, 2017)
Start date: 2017-09-01
End date: 2019-02-28
Duration (months): 18.0
Total project cost (EUR): 598562.5
EU funding (EUR): 598562.5
Participants: 2
Project status: CLOSED

The aim of this supporting action is the planning and the organization of the World Manufacturing Forum 2018 (WMF2018), to be held in the second semester of 2018. Keeping the WMF2018 in Europe is pivotal in order to retain the European leadership in key Manufacturing enabling technologies. The aim of this specific proposal is the planning and the organization of an event that can represent the flagship initiative for the year 2018. In order to take advantage of the previous experiences and reputation accomplished, the event will be called World Manufacturing Forum 2018. Strategic objectives of the event are: • To be an open and independent environment where industry leaders and key policy makers from all over the world, together with all the relevant stakeholders, can discuss global trends, challenges, threats and objectives in Manufacturing, to give advice in policy, science and industry for the orientation of innovation perspectives for a global competitive and sustainable development; • To be a platform where the most relevant and recent State-of-the-Art of the Manufacturing Innovation is spread and disseminated from a public policy perspective and at the same time where the most important trends and innovation needs are identified, discussed and shared, among interested parties and involved communities; • To be a platform for the communication of the European Commission strategies and policies to a global audience (this event could be pivotal to the global dissemination of the process started in the EU Industry Day of the 28th of February 2017 and about EC Digitising European Industry Communication published in April 2016); • To be a striving event to present results of the European cooperative research, to support the Horizon2020 and to discuss about international cooperation in R&D; • To create visibility and better synergies between industrial and social initiatives launched by the Commission and by the Member States in a fair interplay with the other global regions.

Keywords: manufacturing,forum,social,environmental,economic,sustainability,global competitive,development,industry 4 0,policy,effra,manufuture
The interaction of environmental conditions and species traits as drivers of species extinctions and community homogenisation (EXTINCT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-02
End date: 2021-01-01
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Climate and habitat change are accelerating the loss of biodiversity at unprecedented rates. To prevent this loss it is critical to understand species extinction patterns globally. Several studies have linked species extinctions with their intrinsic lifehistory and ecological traits. However, the predictive power of the models is weak generating great uncertainty for applied conservation strategies on the ground. An important factor that is often forgotten is that species extinctions are the culmination of a sequence of local population declines or extirpations, each of which may present distinct trait-environment dynamics. There is still little knowledge on how factors related to species traits and those related to the environmental conditions occurring at the population level interact to drive species declines. Neither is well known how these processes scale up to determine community homogenisation. EXTINCT will use citizen-based data of ca. 175 butterfly species collected over >18 years along three countries (UK, South Finland and NE Spain) to test how the species traits and the environmental conditions interact in driving population declines and extirpations, and the consequent community homogenisation. Specifically, EXTINCT will use butterfly intrinsic traits found to be key in the species ecology and representative of wider taxa, and it will test how they interact with the environmental conditions in terms of climate (aridity) and landscape heterogeneity (topography and landcover heterogeneity). EXTINCT covers six out of the ten bioclimatic regions and three main biomes along Europe, ensuring the generalisations of the findings. It will use modern Bayesian Hierarchical models to correct the ecological inferences from the error inherent to data collected by volunteers. With an applied perspective, it will also inform on the level of local landscape heterogeneity (and thus, management) required to preserve the species, which comprise the local community.

Keywords: species extinctions,community homogenisation,species traits,population trends,climate change,environmental heterogeneity,citizen science,bayesian hierarchical models
Robust and Efficient processes and technologies for Drop In renewable FUELs for road transport (REDIFUEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Belgium,Finland,Hungary,Netherlands
Call: Development of next generation biofuels and alternative renewable fuel technologies for road transport (H2020-LC-SC3-2018-RES-SingleStage, 2018)
Start date: 2018-10-01
End date: 2022-01-31
Duration (months): 40.0
Total project cost (EUR): 4999187.5
EU funding (EUR): 4999187.5
Participants: 13
Project status: CLOSED

The overall objective of REDIFUEL is to enable the utilization of various biomass feedstock for an ultimate renewable EN590 diesel biofuel (drop-in capable at any ratio) in a sustainable manner. REDIFUEL’S ambition is to develop new technologies, solutions and processes to be integrated to reach high conversion efficiencies for renewable fuel production. And, to proof the techno-economic potential to reach a highly competing production cost level of € 0.90 - 1.00 per litre (depending on biomass source) at moderate production plant sizes, e.g. 10-25 kt/a. The proposed drop-in biofuel contains high-cetane C11+ bio-hydrocarbons and C6-C11 bio-alcohols which has exceptional performance with respect to combustion and soot-inhibition properties. The environmental and the society aspects are taken into account by a comprehensive Biomass-to-Wheel performance check of the developed technologies.

Keywords: next generation renewable fuels
Enhancing gene network inference from single-cell transcriptomics data through biophysical constraints (scNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Regulatory processes within living cells have long been the topic of research interest and the key to understanding various diseases. The decades of studies resulted in a large body of knowledge on molecular interactions and regulatory pathways in the cells of model organisms ranging from microorganisms to mammals. Nevertheless, accurately inferring gene network topology at the scale of a whole cell has remained an intractable task until recently, mostly due to the large amount of single-cell data needed for such inference. In the last few years, single-cell RNA sequencing (scRNA-seq) technology enabled measuring transcriptome of high numbers of individual cells, which allowed observing a much grater share of the multidimensional parameter space of large gene networks and gave rise to multiple inference methods. However, none of the existing methods incorporates all relevant knowledge on biophysical constraints. This project aims to incorporate prior knowledge on the system; decomposition of measurement, extrinsic and intrinsic noise; and accurate representation of stochastic gene expression and its regulation into a Bayesian inference framework for identifying topology of a gene network and rate constants of its molecular interactions. The performance of the inference algorithm will be tested by evaluating its ability to predict the effects of transcription factor deletion perturbations. Enhancing gene network inference by accounting for the wealth of known biophysical constraints could provide insights into the gene regulatory processes that would enable advancement in developmental and evolutionary biology, biomedicine and bioengineering.

Keywords: single cell rna sequencing,integrative analysis of heterogeneous data,noise decomposition,network inference,network perturbation analysis