Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From Household Allocations to Global Inequality: New Methods, Facts and Policy Implications (UNEQUALWITHIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Sweden,Norway,Tanzania, United Republic of
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 1999963.75
EU funding (EUR): 1999963.75
Participants: 3
Project status: TERMINATED

To understand and mitigate economic inequalities, both locally and globally, we need to acknowledge inequalities within households. Yet, in most empirical studies, such intra-household inequalities are disregarded mainly because we lack appropriate measurement tools and data. Not only is this problematic for inequality measurement, this lack of understanding hampers the design of cost-effective poverty reduction and child development policies. This project has five general objectives. First, I will update the facts about inequalities through direct measurement of intra-household consumption allocations, and relate these to spousal income contributions. Second, I will develop and validate novel measures of parental resource-allocation preferences and use these to study whether children are likely to benefit more if mothers, rather than fathers, receive cash transfers. Third, I will develop and validate novel measures of household decision-making and use these to investigate how targeted transfers shape women’s empowerment. Fourth, I will study whether cash transfers or an educational parenting program is most cost-efficient for child development. Fifth, I will use an integrated framework and the new tools and data, to refine our understanding of the mechanisms behind inequalities among adults and child development. Concretely, the project will contribute to our knowledge in the following specific ways. I will carry out an extensive data collection on intra-household allocations, parental-allocation preferences and women’s empowerment, in ten very diverse countries, one from each decile of the world income distribution. I will engage in a local RCT in Tanzania on cash transfers and parenting, which also involves extensive data collection on household consumption, time use, preferences and decision-making. Finally, I will conduct lab experiments in Chile, India and Tanzania so as to validate the parental-allocation preference and decision- making measures.

Keywords: inequality,households,child development,gender equality
TrojanDC - A BREAKTHROUGH DEEP-TECH INNOVATION FOR CANCER IMMUNOTHERAPY (TrojanDC)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Sweden
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The Challenge: Cancer remains one of the major challenges to modern medicine affecting one-in-three people in Europe. Available immunotherapies are effective in a limited number of patients and often lose their efficacy due to heterogeneity and lack of tumor-antigen presentation. Despite these shortcomings, the global immune-oncology market is one of the fastest growing therapeutics markets. Large players like Merck, Pfizer, and Novartis have shown to be keen on acquisitions of high-potential technologies. There is thus an urgent need and high demand for innovative cost-effective immunotherapies consistently effective in a broader range of cancer patients. The innovation: Asgard Therapeutics is a pre-clinical start-up company developing innovative cancer immunotherapies based in in-vivo cell reprogramming. The company is led by the scientific co-founder and CEO Cristiana Pires who, together with her co-founders, pioneered direct reprogramming to induce antigen-presenting dendritic cells. Asgard raised a € 6M seed round of funding to generate proof-of-concept for its lead candidate TrojanDC, a paradigm-shifting immunotherapy that reprograms cancer cells into antigen-presenting dendritic cells, allowing the presentation of their tumor antigens to the immune system, thereby eliciting potent anti-cancer immunity. TrojanDC has the potential to overcome challenges with current immunotherapies by reinstating cancer immunogenicity. The Women TechEU grant will allow defining a clear roadmap for the IND-enabling studies and FIH clinical trials and creating a comprehensive business plan required to raise Series A funding in Q4 2023. The Impact: With strong proof-of-concept data already obtained, an exceptional team of high-performing scientists and a strong syndicate of seasoned VCs, Asgard Therapeutics is in a unique position to develop first-in-class cancer immunotherapy based in in-vivo reprogramming.

Keywords: cancer immunotherapy,direct reprogramming,dendritic cells,solid tumors
HARMONIsed network through smart technology and Collaboration (HARMONIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Belgium,Spain,Austria,Italy,Slovakia,Poland,Switzerland,United Kingdom,Germany,France
Call: Industrial Research & Validation for Master Plan Phase C Civil-military Interoperability & Coordination (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 12994573.25
EU funding (EUR): 4650794.29
Participants: 19
Project status: SIGNED

Based on the results obtained mainly from SESAR W2, this project completes key developments of the Demand and Capacity Balancing (DCB) operational concept in those areas where improvements would make the implementation of the operational concept more efficient. The core focus being: -to provide automatic support for spot analysis and particularly resolution, using what-if simulations that can find optimal solutions with most appropriate combinations of airspace configurations, choice of flights and measure or set of combined measures selection; -to integrate and harmonise the constraints of the network actors, such as departure and arrival airports, Integrated Network management and ATC Planning (INAP) Actors, Terminal Management Areas (TMA) and the Airspace Users (AU), to supply network-wide solutions that respect constraints and priorities as far as possible; -to further integrate the Dynamic Airspace Configuration (DAC) concept with INAP and Network Management (NM), increasing the flexibility of the process to be more efficient in the usage of available capacity. The main benefits that the project will provide are an increase of capacity, cost-efficiency of Air Traffic Services (ATS), flexibility and cost reduction of AU and fuel efficiency. The developments are grouped into two solutions: -Enhanced Demand Management, covering the two first areas; -Dynamic Airspace Configuration, covering the third. It is a goal for this project to provide mature evolutions to the forementioned concepts, with some elements becoming candidates for early deployment and that can integrate the new architecture of integrated Network Management (iNM).

Keywords: trl6,maturity,integration,interoperability,dac civil military,capacity,nm,dynamic,flexibility,automated tools,constraints,digit inap what if,ai,ml,sectorisation,dac dcb integr,airline cost
Epigenetics of Bladder Cancer Evolution. (Epi-BCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Greece,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 197263.68
EU funding (EUR): 197263.68
Participants: 2
Project status: SIGNED

Cancer is one of the leading causes of death worldwide and its management remains challenging. Tumor evolution, the process of genetic and epigenetic divergence and selection of cancer cell clones in a heterogeneous tumor, is a key aspect of disease progression and therapy resistance. The main goal of this proposal is to expand our understanding of the biological mechanisms involved in these processes. So far, the role of chromatin regulation and epigenetics in tumor evolution remains poorly characterized and understood. This is particularly relevant in bladder cancer where mutations in chromatin regulation are very frequent and are associated with advanced and therapy resistant disease. Epi-BCE will advance the state-of-the-art through the discovery of epigenetic mechanisms that drive bladder cancer progression and chemoresistance in cell subpopulations, and tumors with chromatin deregulation. Specifically, I will utilize a carcinogen-based mouse model of bladder cancer that recapitulates human cancer stages from early to advanced and therapy resistant disease. I will perform transcriptomics and epigenomics at bulk and single-cell level at stages of disease progression. In addition, I will employ genetically engineered mice with ablation of chromatin regulation proteins, integrative computational analysis and functional genetic experiments to identify key mechanisms. Epi-BCE will be a platform for professional growth. I will receive technical training in experimental mouse models, bioinformatics, and 3D genomics through a secondment. I will engage in new professional networks and acquire transferable skills. Grantsmanship activities will support the fellow towards a path to independence. Overall, the proposed experiments will yield scientific knowledge and reusable datasets on cancer biology. These outcomes will promote and accelerate future research on cancer management and therapeutics.

Keywords: tumor evolution tumor heterogeneity single cell multi omics cancer epigenetics bladder cancer model genetically engineered mouse models cancer therapy
ScieNcE Together (NET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-03-11
End date: 2026-03-10
Duration (months): 24.0
Total project cost (EUR): 821798.82
EU funding (EUR): 774988.11
Participants: 13
Project status: SIGNED

Throughout its history, Rome has been a leading centre for culture and science, and still today the city and its environs are home to Italy’s largest concentration of research centres, laboratories and universities; in fact one of the largest concentration in Europe. In 2019, the ScieNcETogether NETwork was established, primarily just by those roman research organizations that had a long-standing tradition of interaction and cooperation among them and with international scientific contests and wanted to lay the foundation for an active collaboration also in science dissemination. In these four years of joint work taught us that to make the Night a more engaging and inclusive experience and address a large number of citizens and young people, joining forces and collaboration is key and brings added value. Consequently we have developed a formula to celebrate the Night: a major event with researchers from all NET partners institutions and representative of the stakeholder groups in Rome (the NET village) but, at the same time, we are also aware that celebrating the ERN means feeling part of a larger European community. So, on the one hand we are inviting the partners’ branch laboratories and research centres scattered all over Italy (20 cities from north to south Italy) to share NET’s objectives and contribute to a national celebration, on the other hand we have searched for partners/project stakeholders outside Italy that could help us enhance the European and international dimension of the ERN. Having based our communication strategy on Marie Slodowska Curie as NET Night goodmother, it has been almost natural to look at Poland (Polish Academy of Sciences), France – (Marie Curie Museum) and Sweden (Tekniska museet | National Museum of Science and Technology), the three countries that sort of represent three different stages in the scientist’s life.

Keywords: network value researchers science stakeholders engagement steam schools excellence he missions green deal cities fun entertainment innovation education health technology ai
How vertically transmitted gut microbes and immune genes synergistically direct anti-malarial defence in birds (BornThisWay)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Mounting an appropriate and effective immune response is critical to protect an organism from infection. In vertebrates, the adaptive immune system (AIS) plays a central role in immunity, and evidence is accumulating that its development is governed by intricate crosstalk between host immune genes and gut bacteria (GB). This implies that specific synergisms exist between bacterial taxa and AIS, mainly encoded by the highly polymorphic Major Histocompatibility Complex genes (MHCs), to promote optimal immunity. However, the specific associations between GB and MHCs in defence against parasites and their potential effects across generations are poorly resolved in one of the largest vertebrate classes: the birds. BornThisWay will close major gaps in our current understanding of immune consequences of GB-MHC crosstalk in wild birds using two ideal study populations. The action will capitalise on my and my host’s (Prof. Helena Westerdahl) extensive backgrounds in avian gut microbiomes and avian adaptive immunity, respectively. BornThisWay will i) establish how GB and MHC act in concert to defend against avian malaria parasites, ii) determine if synergistically optimal protection is transferred across generations, and iii) test immune consequences of GB-MHC crosstalk disruptions. BornThisWay will add a new dimension to host-pathogen interactions in wild birds, generate novel fundamental insights into the adaptive significance of GB-MHC crosstalk, and provide transformative insights of conceptual and empirical value to transgenerational immunity in vertebrates.

Keywords: birds,gut microbiomes,malaria infections,mhcs,transgenerational immune priming
Investigating the role of KDM4 demethylases on extraembryonic lineage competency in mice and humans (KICK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-15
End date: 2027-05-14
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

During the first two weeks of human development, the embryo will generate sequentially progenitors of the extraembryonic membranes that will form the supportive tissues of the embryo proper. Impairments of their development have been linked to pregnancy diseases such as preterm birth. Human embryonic cells differ from mice by their remarkable plasticity, which allows them to generate extraembryonic lineages during a protracted period of time. The mechanism extending human embryonic cells competency remains a mystery. Enzymes of the KDM4 family remove Histone 3 lysine 9 methylation, a major epigenetic barrier to lineage conversion. However, there is a dramatic lack of knowledge on the role of KDM4s during early embryonic development. In this project I will investigate the function of KDM4 demethylases and how they influence embryonic cell competency in humans and mice. Human embryonic stem cells (hESC) and derivatives can be used as models of embryonic counterparts and possess equivalent extraembryonic lineage competency. In addition, hESC can be made to self-assemble into more complex 3D embryo models. These models provide an exciting and more accessible alternative to human embryos. In this project, I will leverage the combined expertises of the host lab and myself in embryology and stem cell based models to chart for the first time the localization of KDM4 demethylases and perturbate their expression with cutting edge CRISPR-dCAS9 technologies in models of human early development. Both myself and the host’s previous works have shown that the manipulation of chromatin regulators can be harnessed to break epigenetic barriers. I will thus use the overexpression of KDM4 demethylases to also enhance mouse embryonic cells competency. Elucidating how human embryonic cells retain extraembryonic plasticity compared to mice will be key to further our knowledge of the specificities of human early development and better understand and model pregnancy disorders.

Keywords: peri implantation embryonic development,extraembryonic lineages,h3k9 methylation,kdm4,human embryo models
Carbon sequestration in BLUe EcoSystems (C-BLUES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Norway,Malta,Netherlands,Italy,France,China,United Kingdom,Spain,Greece,Germany,Türkiye,Sweden
Call: EU-China international cooperation on blue carbon (HORIZON-CL5-2023-D1-02, 2023)
Start date: 2024-04-01
End date: 2028-03-31
Duration (months): 48.0
Total project cost (EUR): 4244081.25
EU funding (EUR): 4244080.5
Participants: 21
Project status: SIGNED

C-BLUES will significantly advance knowledge and understanding of blue carbon ecosystems (BCEs) seagrasses, tidal marshes, mangroves, macroalgae, and macroalgae mariculture aiming to achieve three overarching objectives: 1) develop new scientific knowledge within BCEs to reduce scientific uncertainty and improve reporting of blue carbon under the United Nations Framework Convention on Climate Change (UNFCCC), 2) provide input to a possible revision of the 2013 IPCC Wetlands Supplement to increase inclusion of coastal wetlands in national greenhouse gas (GHG) inventories and reporting, 3) raise awareness and promote the role of blue carbon for delivering global climate policy commitments in collaboration with Chinese and other international partners. C-BLUES will perform the following: produce spatial maps, methodological best practices and standard operating procedures; enable more robust and reliable quantification of carbon emissions and sequestration; model sequestration capacity and upscale regional and global GHG budgets; assess carbon stock changes, GHG emissions and removals related to different management interventions and human activities; review legal and institutional frameworks governing BCEs; and assess the drivers and barriers for integrating coastal wetlands into national reporting mechanisms under the UNFCCC. C-BLUES will target the following Mission Ocean Lighthouse Areas (LA): LA Atlantic/Arctic, LA Baltic and North Sea, and LA Mediterranean Sea. The Black Sea, Dutch Antilles, and through collaboration with China, the Southern China coast will also be covered. C-BLUES will engage with the scientific community, climate and coastal policy makers and the wider civil society to disseminate the knowledge generated, raise awareness of BCEs and build capacity for blue carbon research inclusion. C-BLUES will effectively impact national and international climate policy work so that BCEs more prominently are included in reporting and management actions.

Keywords: blue carbon ecosystems
Reliable humanoid workforce in agriculture (Robot Farm Assistant)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Switzerland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

We want to build an alternative humanoid farm labor force. We equip them with 3D perception and precise finger manipulation skills to let them touch the plants. Today human is almost the only solution when it comes to precise harvesting, pruning, any many other tasks in CEA (Controlled Environment Agriculture) and other high-value crops. Humanoids on the other hand have evolved very rapidly in locomotion and manipulation skills in structured and human-made environments. But agriculture is about biological systems, which vary plant to plant, fruit to fruit. Here comes the 5 years expertise of Floating Robotics. We have developed many of these skills on grapes and tomatoes for harvesting, pruning and lowering. With more than 4 years of piloting and day-to-day field testing, our tomato harvester is now at TRL8. One unit has reached about 20000 cuts today per robot and works very reliably with zero damage to the plants. We have this knowledge in-house, and we want to mount it on humanoids as we believe this form-factor dominates the industry thanks to its mass production happening now. This creates a much cheaper and more versatile robotic labor compared to customized wheeled robots. Our aim is manipulation and not transportation. Every farm indeed has its own transportation logistics made for humans. So building wheeled robots carrying manipulation systems is a redundant work, if not reinventing the wheel. We are looking for your help to correct the course of ag-tech robotics! Profitability depends on hardware price, but also manipulation speed and precision KPIs. We have the software core at Floating Robotics built for a humanoid form factor. It's time to transfer it to real humanoids.

Keywords: automation,hand manipulation,greenhouse,tomato,learning,ai,humanoid,robot