Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A MAGNETO-ELECTRIC LIQUID – BETTER SENSING (MAGNELIQ)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Slovenia,Slovenia,Czechia
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 2992755.0
EU funding (EUR): 2992755.0
Participants: 5
Project status: SIGNED

Our radical vision of a science-enabled technology is a magneto-electric (ME) liquid for new devices like distributed-force sensors that can transform complex structures like the skins of humanoid robots and artificial body parts. A ME material is characterised by having magnetic properties that can be manipulated with an electric field and, vice versa, electric properties that can be manipulated with a magnetic field. Until now the only ME materials have been solid-state mutliferroics, because until recently ferroic properties were considered to be specific to solid materials. However, based on our recent discovery of ferromagnetic liquids, which overturned this established paradigm, we propose a breakthrough liquid ME material. The basic component of this ME liquid will be ME nanoplatelets (NPs), i.e., magnetic NPs that will be hybridized with electrically polarized organics. These ME-NPs will then be dispersed in a nonconductive liquid medium, where they will be able to reorient in an external field. At volume concentrations of >10 vol.% ME-NPs multiferroic liquids will be formed and characterized by a simultaneous spontaneous polarization and magnetization without an externally applied field. A new surface-selective hybridization technology will be developed together with the synthesis of electrically polarized organics for the fabrication of the ME-NPs. The ME liquids will be realised with an all-new multiscale modelling framework; the chemical interactions and physical properties of an individual magnetic NP with organic ligands will require ab-initio calculations; and phenomenological models will account for the complex interactions between all the system phases, including the system’s interaction with external fields. The envisioned ME-liquids-enabling technologies will surpass current sensing paradigms by providing contactless and remote operation, low energy consumption, wireless signal transmission, distributed sensing and miniaturization.

Keywords: magneto electric,liquid,hybrids,modelling,sensors,robotics
Climate change across Cenozoic cooling steps reconstructed with clumped isotope thermometry (C4T)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Norway
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2021-01-31
Duration (months): 66.0
Total project cost (EUR): 1877209.0
EU funding (EUR): 1877209.0
Participants: 1
Project status: CLOSED

The Earth's climate system contains a highly complex interplay of numerous components, such as atmospheric greenhouse gases, ice sheets, and ocean circulation. Due to nonlinearities and feedbacks, changes to the system can result in rapid transitions to radically different climate states. In light of rising greenhouse gas levels there is an urgent need to better understand climate at such tipping points. Reconstructions of profound climate changes in the past provide crucial insight into our climate system and help to predict future changes. However, all proxies we use to reconstruct past climate depend on assumptions that are in addition increasingly uncertain back in time. A new kind of temperature proxy, the carbonate ‘clumped isotope’ thermometer, has great potential to overcome these obstacles. The proxy relies on thermodynamic principles, taking advantage of the temperature-dependence of the binding strength between different isotopes of carbon and oxygen, which makes it independent of other variables. Yet, widespread application of this technique in paleoceanography is currently prevented by the required large sample amounts, which are difficult to obtain from ocean sediments. If applied to the minute carbonate shells preserved in the sediments, this proxy would allow robust reconstructions of past temperatures in the surface and deep ocean, as well as global ice volume, far back in time. Here I propose to considerably decrease sample amount requirements of clumped isotope thermometry, building on recent successful modifications of the method and ideas for further analytical improvements. This will enable my group and me to thoroughly ground-truth the proxy for application in paleoceanography and for the first time apply it to aspects of past climate change across major climate transitions in the past, where clumped isotope thermometry can immediately contribute to solving long-standing first-order questions and allow for major progress in the field.

Keywords: paleoceanography,cenozoic,foraminifera,ocean circulation,climate change
Sediment linkage between land, river and sea: evaluating impacts of historic mining on sediment quality in the coastal zone (SEDiLINK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Monitoring datasets available to evaluate past mining impacts on catchment and coastal environmental quality are severely limited in temporal extent presenting a major hindrance to effective decision making for management of legacy pollution to achieve the goals of the EU Water Framework Directive and Mining Waste Directive. The “Sediment linkage between land, river and sea: evaluating impacts of historic mining on sediment quality in the coastal zone” (SEDiLINK) research project will develop an innovative sedimentological approach to overcome these important challenges and close this substantial knowledge gap. The SEDiLINK approach will bring together established techniques (e.g. Pb-210 geochronology) with new approaches in evaluating riverine ecosystems (e.g. Pb isotope fingerprint) and deliver an integrated toolkit for evaluation of mine waste impacts. The extensive metal mining history of Tamar River Basin and coastal zone, southwest UK, offers an ideal test-bed in which to develop the novel and powerful SEDiLINK approach for wider application in other EU contaminated fluvial and coastal ecosystems requiring longer term remediation legacy pollution. Through developing this tool, the candidate will gain new scientific and technical skills in cutting edge isotopic fingerprinting techniques working with multidisciplinary and multinational groups in UK and Spain, developing and complementing her previous knowledge in radiotracer applications. This period of advanced training and mobility will underpin maturation and independence as a leading EU researcher.

Keywords: catchment sediment dynamics,sedimentation,floodplain,salt marsh,coastal management,mining pollution,isotopic fingerprinting
optimal fuel consumption with Predictive PowerTrain control and calibration for intelligent Truck (optiTruck)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Italy,Italy,Italy,Germany,Italy,Italy,Italy,Türkiye,Türkiye,Greece,Belgium,Denmark,United Kingdom
Call: Powertrain control for heavy-duty vehicles with optimised emission (H2020-GV-2015, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 5385958.75
EU funding (EUR): 4540988.88
Participants: 18
Project status: CLOSED

The automotive industry has made a substantial effort in recent years in developing powertrain technologies to improve fuel efficiency on Heavy-Duty Vehicles (HDVs). Due to increasing road freight traffic, however, projections indicate that total HDV energy use and CO2 emissions are expected to remain stable at the current level over the long term, if no policy action is taken. This is clearly incompatible with the goal of reducing greenhouse gas emissions from transport by around 60% below 1990 levels by 2050. The overall objective of optiTruck is to further improve energy efficiency by at least 20% on Euro VI HDVs (40t). To achieve this, optiTruck will develop a global optimiser which brings together the most advanced technologies from powertrain control and intelligent transport systems, with a number of innovative and complementary elements to maximise the potential utilisation of individual innovations. Through real driving trials, optiTruck will demonstrate this objective, taking account road topography, traffic and weather condition, vehicle configuration and transport mission. optiTruck will develop a comprehensive impact assessment methodology to extend this local and small-scale demonstration to a wider evaluation to explore potential benefits of using the rich cloud data sources and powerful computing facilities for fast-than-real-time modelling and simulation. It will also take account of social equity, economic, and environmental factors in the assessment to address the main societal challenges for the sector. optiTruck will facilitate the creation of a global platform not only for exchanging existing knowledge between automotive industries, but also for promoting horizontal collaboration in new ways essential for wider uptake of energy saving solutions across the sector, Europe and the world, which is the ultimate goal the optiTruck partners strive to achieve within and beyond this project.

Keywords: predictive powertrain control,heavy duty vehicles,optimised emission,global optimisation,transport mission,cloud computing
Plant cell wall communication and remodelling: the wall watchers. (WallWatchers)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 1499966.0
EU funding (EUR): 1499966.0
Participants: 1
Project status: SIGNED

Plants, just like animals are highly developed multicellular organisms. In contrast to animal cells however, plant cells are surrounded by a rigid, carbohydrate-rich extracellular layer, the cell wall. This cell wall provides plants with mechanic support and a dynamic chemical signalling and metabolic environment. To allow for cell expansion, cell division, coordinated tissue growth and interactions with the environment, the cell wall status constantly needs to be sensed and modified. How plant cells perceive and signal their cell wall status is poorly understood. Here, I propose an integrated approach to uncover ligands for cell wall sensing receptors as well as their downstream signalling components. Specifically, my project aims to identify the ligands for two genetically validated cell wall receptor families, using a chemical biology approach. Next, we will analyse and validate the mode of ligand-receptor interaction by combining protein X-ray crystallography, quantitative biochemistry and reverse genetics in Arabidopsis. A detailed ligand-binding and receptor activation mechanism will allow us to specifically interfere with cell wall receptor function in vivo, and to assess their biological relevance for cell wall structure and its chemical properties. Using atomic force microscopy, we will then test if the receptors are distributed uniformly at the membrane or whether they are arranged in complex 'sensosomes'. Finally, we will characterize if plant cell wall receptors can directly act as mechanosensors. With defined receptor-ligand pairs and clear phenotypes at hand, we will try to uncover downstream signalling components for plant cell wall receptors and to validate our atomic models in planta. My ultimate goal would be to design and test cell wall receptor agonists and antagonists, which will represent powerful tools to alter cell wall homoeostasis in Arabidopsis, and potentially in crops.

Keywords: cell wall,membrane receptor kinase,plant signalling,protein,receptor activation,protein structure
TinniMizer : A Patient-specific Novel Approach for Tinnitus Treatment (TinniMizer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Türkiye
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Tinnitus can be a debilitating condition, which negatively affects a patient’s overall health and social well-being. Even moderate cases can interfere with the ability to work and socialise. The financial consequences of tinnitus are significant. Personal economic loss to an individual with tinnitus--including lost earnings, productivity, and health expenses--can be up to €30,000 annually. The cost to society as a whole has been estimated at upwards of €26 billion annually. Despite these effects there is currently no scientifically proven cure for most cases of chronic tinnitus. The medical doctors (ENT specialists), audiologists, and electronics-biomedical engineers in Genmel Technology have developed a new, patient-specific, state-of-the-art, and patented musical therapy system called TinniMizer as a new treatment for Tinnitus due to a substantial need to cure the tinnitus with an easy-to-use and cost-effective therapeutic system. Preliminary results obtained from about 20 patients at three clinics (Tinnitus Treatment Centers) indicate that after using TinniMizer system for about 3 months, there is approximately 70% reduction in the complaints of tinnitus patients. Through this project, Genmel will further develop this therapy to result in over 95% reduction in tinnitus. In other sound therapy systems, the duration of therapy is 1.5 years. Our goal is to reduce this period to a much shorter period (up to 3 months). Genmel offers R&D solutions, productions, and consulting services especially in the field of Biomedical, Electronics, Medicine and Energy. Academicians, engineers and technicians are working in GENMEL. The main goal of GENMEL is to develop and bring to market new products, services and business models that could drive economic growth. Through this project, Genmel aims to achieve a total turnover of >€14.5 million by the 5th year of TinniMizer commercialization.

Keywords: tinnitus,treatment,bio medical,musical therapy,clinical trials,audiologist,otologic
Post-Newtonian modelling of the dynamics of supermassive black holes in galactic-scale hydrodynamical simulations (KETJU) (KETJU)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-07-01
End date: 2025-09-30
Duration (months): 75.0
Total project cost (EUR): 1953569.0
EU funding (EUR): 1953569.0
Participants: 1
Project status: SIGNED

Supermassive black holes (SMBHs) with masses in the range ~10^6-10^10 M⊙ are found at the centres of all massive galaxies in the Local Universe. In the ΛCDM picture of structure formation galaxies grow bottom-up through mergers and gas accretion, leading to multiple SMBHs in the same stellar system. Current simulation codes are unable to resolve in a single simulation the full SMBH merging process, which involves dynamical friction, three-body interactions and finally gravitational wave (GW) emission. KETJU will provide a significant breakthrough in SMBH research by following for the first time accurately global galactic-scale dynamical and gaseous astrophysical processes, while simultaneously solving the dynamics of SMBHs, SMBH binaries and surrounding stellar systems at sub-parsec scales. Our code KETJU (the word for 'chain' in Finnish) is built on the GADGET-3 code and it includes regions around every SMBH in which the dynamics of SMBHs and stellar particles is modelled using a non-softened Post-Newtonian algorithmic chain regularisation technique. The remaining simulation particles far from the SMBHs are evolved using softened GADGET-3. Using KETJU we can study at unprecedented accuracy the dynamics of SMBHs to separations of ~10 Schwarzschild radii, the formation of cores in massive galaxies, the formation of nuclear stellar clusters and finally provide a realistic prediction for the amplitude and frequency distribution of the cosmological gravitational wave background. The UH theoretical extragalactic team is ideally suited for this project, as it has an unusually versatile background in modelling the dynamics, feedback and merging of SMBHs. KETJU is also particularly timely, as the spectacular direct detection of GWs in 2016 is paving the way for a new era in gravitational wave astronomy. Future space-borne GW observatories, such as the European Space Agency's LISA, require accurate global GW predictions in order to fully realise their science goals.
Clinical validation of a bioMARKer for use in INtestinal PATHologies (MARKinPATH)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

MARKinPATH global innovation project aims at undertake the clinical validation of Xylose, after ingestion of Gaxilose, as a Biomarker of intestinal diseases. Currently, the measurement of Xylose after ingestion of Gaxilose is used to evaluate hypolactasia in adults. MARKinPATH is focused to improve the hypolactasia diagnosis; broaden the pathologies to monitor and to extend his use to paediatrics population. MARKinPATH will meet the demand of the EU on and innovation in healthcare, by enhancing diagnosis and management of intestinal pathologies. The resulting solution will also contribute to cost-effective and efficient health expenditure. Xylose-based, after ingestion of Gaxilose, biomarker improves technical features such as specificity and sensitivity with respect to the other tests available in regular clinical practice. Furthermore, alternative methods such as Hydrogen breath test (HBT) and the Lactose tolerance test (LTT) are invasive and have adverse effects that can be very annoying for the patient. Venter Pharma is a highly innovative SME with more than 11 years focused on advanced research, development and commercialization of clinical solutions in this field. Venter Pharma has a relevant Intellectual Capital and an extensive background in these technologies. MARKinPATH would suppose a massive-but-necessary growth and the consolidation of Venter Pharma in the pharmaceutical market.

Keywords: gaxilose,xylose,intestinal pathologies,clinical validation,point of care poc
Living Evidence to inform health decisions: Development of capacity for the production and use of reliable, friendly and updated health evidence synthesis. (Living Evidence)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-07
End date: 2022-09-13
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Further efforts to achieve greater efficiency in allocating healthcare resources are needed in order to guarantee the sustainability of public health systems. The exponential production of new evidence is a challenge in achieving this goal. Newly validated innovative technological tools for systematic evidence identification, evaluation, and synthesis may allow for a more efficient production of evidence to inform healthcare decisions. However, it is essential to build capacity among health care professionals to properly use these tools as well as formulate collaborative strategies to implement them. This research proposal aims to evaluate a strategy for capacity building to produce "Living Evidence" syntheses to generate integrative evidence-based products that support decision-making. Consists of three complementary projects aimed at: [WP1] producing Living Overviews of previously selected priority topics in the area of cancer and respiratory diseases integrated into the Epistemonikos-L.OVE project, an innovative initiative and platform in progress that allows to generate systematic evidence synthesis in a rigorous and efficient way, displaying it in a friendly format; [WP2] preparing and disseminating Friendly Summaries of Evidence for highly relevant questions from the prioritized health topics to inform clinicians and decision makers, following validated methods; and [WP3] updating evidence supporting recommendations in clinical practice guidelines (Living Guidelines) related with the same topics, through the development of living overviews in collaboration with two European guideline developers, and following the GRADE approach to rate the quality of evidence and generate summary of findings tables. In addition to the delivery of training, the project proposes a collaborative work strategy with different actors in the health system to carry out these actions. Information will be collected throughout the whole process to assess the efficiency of this strategy.

Keywords: systematic reviews,evidence based practice,living evidence,information for health policy,knowledge translation