Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Protein glycosylation and glucose variability patterns for precision nutrition in diabetes (GLUCOTYPES-HopOn) (GLUCOTYPES-HopOn)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Denmark,Croatia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 42.0
Total project cost (EUR): 593125.0
EU funding (EUR): 593125.0
Participants: 2
Project status: CLOSED

GLUCOTYPES-HopOn expands the GLUCOTYPES project by incorporating large-scale glycosylation profiling through the participation of the widening partner, Genos. Specializing in high-throughput glycomics, Genos has contributed glycomic data to over 200,000 samples from population, epidemiological, and clinical studies. With a focus on biomarker discovery and commercialization, Genos brings valuable expertise to the GLUCOTYPES Consortium. Previous research at Genos has shown that glycan biomarkers can predict the development of type 2 diabetes (T2D) independently of traditional risk factors, offering complementary insights. Genos demonstrated that individual differences in plasma protein N-glycome composition can predict T2D up to 10 years before onset with gradual changes in the N-glycome becoming evident years before clinical signs of insulin resistance or T2D appear. By analyzing total serum/plasma N-glycans in 11,000 samples available through the GLUCOTYPES project using advanced technologies, Genos will actively support the project's goal of developing personalized dietary strategies to address food-related health conditions (FrHCs) and non-communicable chronic diseases (NCDs). The integration of Genos will follow the project's existing structure, with dedicated subtasks across several work packages, ensuring smooth incorporation of high-throughput glycomics analysis. The GLUCOTYPES-HopOn extension will enhance glycosylation profiling capacity, strengthen commercialization efforts, and boost the impact of the GLUCOTYPES Consortium, potentially opening new research avenues.

Keywords: glucotypes,glycomics,high throughput,protein glycosylation,type 2 diabetes
DNA methylation markers to predict treatment success of biologicals in Crohn’s disease. (METHYLOMIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Netherlands,Spain,Belgium,United States,United Kingdom,Italy,Hungary,Slovenia,Portugal
Call: Optimising effectiveness in patients of existing prescription drugs for major diseases (except cancer) with the use of biomarkers (HORIZON-HLTH-2022-TOOL-11, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 9376995.25
EU funding (EUR): 9376995.25
Participants: 20
Project status: SIGNED

Monoclonal antibodies have become a mainstay of therapy in common immune-mediated diseases (IMID) including Crohn’s disease (CD), rheumatoid arthritis (RA), and psoriasis (PsO). Current therapeutics include antibodies (“biologicals”) targeting inflammatory proteins such as Tumor Necrosis Factor (adalimumab), leukocyte trafficking (vedolizumab), or IL-12/IL-23 (ustekinumab). At present however, it cannot be predicted which biological will be effective in an individual patient, with only <40% of patients showing primary response to any given therapeutic. Treatment failure is associated with disease complications, and increased health care costs.. Hence the overwhelming need for predictive biomarkers to guide personalised medicine in IMID is evident. No biomarker to target therapy is validated in clinical practice. In METHYLOMIC, we build on multiple previous cohort studies in which we confirmed epigenetic biomarkers (specifically DNA methylation) as the most stringent predictor of response to biological therapy, zooming in on CD. Specifically, we discovered and validated differential DNA methylation profiles in peripheral blood as biomarkers of response/deep remission for 3 approved biologicals in CD. Through the use of machine learning algorithms, treatment response could be predicted with up to 93% accuracy for each biological for CD, and RA. METHYLOMICS is committed to bringing personalised treatment-selection in CD and other IMID to clinical practice. We have teamed up clinical, epigenetic, and DNA diagnostics experts, patient organisations, and companies across Europe, for further validation studies, develop a marketable rapid targeted methylation assay that we than validate in a unique prospective randomised clinical trial for CD. Efficiency and cost-effectiveness is assessed in great detail and regulatory approval is guided by experts to assure delivery of the first epigenetic kit personalised treatment of CD.

Keywords: crohn s disease,epigenetic biomarkers,biological treatment response prediction,ngs targeted methylation assay development,machine learning,prospective clinical trial
Path towards a sustainable Mediterranean Sea: mitigation actions to cope with Marine Heat Waves (SEAFIRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-16
End date: 2025-11-15
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 3
Project status: CLOSED

The ocean has stored at least 89% of the excess heat due to human-induced greenhouse gas emissions, making climate change irreversible. Ocean warming trends over the past 50 years have not been homogenous, and some regions known as Marine Hotspots have experienced warming at a rate faster than 90% of the rest of the oceans. Superimposed on these long-term trends, devastating Marine Heat Waves (MHWs) are defined as episodes of anomalous warming in the ocean that can last from a few days to months. These extreme events have drawn scientific and public attention recently due to their dramatic consequences on marine ecosystems and their associated strong socio-economic impacts. Understanding how marine ecosystems respond to climate change, and in particular to MHWs, has been recognized as a major societal challenge, and there is an evident need for a wide range of tools such as management and conservation plans to cope with the disruptive MHWs in order to prevent species depletion and ensure seafood provisioning. Within this context, SEAFIRE aims at (i) providing relevant information about the impact of MHWs by characterising them, (ii) improving our understanding of the marine ecosystem’s responses to these extreme events, (iii) proposing mitigation actions and testing their potential effectiveness on the Western Mediterranean Sea. Achieving these goals requires a multidisciplinary approach coupling physics with the ecosystem’s functioning and vulnerability. The project combines the expertise acquired by the fellow in physical processes related to MHWs with the expertise provided by the supervisor in marine ecosystem functioning and modelling. Specifically, the project will merge cutting-edge technologies from different disciplines such as high-performing physical and biogeochemical models, in-situ observations, fishing data, ecosystem modelling and a new "Digital Twin Ocean" platform.

Keywords: marine heat waves climate change physical oceanography marine ecosystems management mitigation actions mediterranean sea digital twin ocean ocean models marine ecosystem models
PlantDevComm: Defining the plant species and development communication ID (PlantDevComm)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 2028750.0
EU funding (EUR): 2028750.0
Participants: 1
Project status: SIGNED

Plants communicate through various mechanisms to adapt to their environment and coordinate survival and reproduction. Understanding plant communication is crucial for developing resilient crops, reducing agricultural environmental impact, and decoding natural ecosystem dynamics. While studies have focused on "alarm" signaling, in which a plant that is exposed to a stressor emits signals that cause neighboring plants to activate stress-coping mechanisms, the realm of constitutive, "steady-state" plant-to-plant communication, though suggested, remains largely unknown. This research aims to uncover the rules governing steady-state plant communication, particularly how plants transmit their identity and how neighbor identity perception influences plant survival. The role of plant species and developmental status in generating routine communication signals is unknown. Our novel and exciting discovery reveals that plant species and developmental stage influence emitted communication signals. We have found that plants can recognize airborne communication from their species ("self") and from other species ("non-self"), and tailor their response to the type of communication perceived. This novel mechanism impacts both development and pathogen resistance in neighboring plants. In this proposal, we will characterize this novel form of plant-to-plant communication, defining the developmental rules of emission and response to different, "suppressive" and "supportive" volatile signatures that constitute the plant species and developmental "volatile ID". We will examine the relationship of the plant volatile ID with the phyllosphere microbial community, and identify novel plant mechanisms that are required for volatile ID sensing and response. Our work will elucidate the role of plant species and developmental identity in the emission, sensing, and response to communication signals, advancing our understanding of plant interactions in diverse communities.

Keywords: plant communication,plant development,volatile organic compounds
The CAESAR IBD Project: Developing Therapeutic Antibodies for Pets (CAESAR IBD Project)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 3481237.5
EU funding (EUR): 2436866.0
Participants: 1
Project status: CLOSED

Inflammatory bowel disease (IBD) in dogs is a common but poorly managed chronic condition causing immense emotional and financial distress to pet owners. Based on the positive results of antibodies to treat IBD in humans they have been proposed for dogs. However, instead of investigating a new drug specific for them some antibodies developed for other purposes and species has been adapted (petization), which can trigger immune responses in pets, yielding ineffective therapies and causing further health complications. At Adivo we have developed and validated CAESAR platform, which is the first fully canine phage-display library to generate therapeutic antibodies specific for dogs overcoming the limitations of current petization techniques. Now we aim to use this technology to develop and validate an effective drug to treat IBD in dogs. This project will bring a cumulative profit of €41 M in the first five years of commercialization, an ROI of 14 and to hire over 15 professionals.

Keywords: animal health,canine,inflammatory bowel disease,phage display,ibd,therpeutic antibodies,social responsibility,dog
Developing an innovative solution for optimal energy use and hygiene products for cellar bar and restaurants (BioSmartBar)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2088625.0
EU funding (EUR): 2088625.0
Participants: 1
Project status: SIGNED

In the hospitality industry both alcoholic and non-alcoholic draft beers are served in many types of outlets from small 1 tap bar to 45 tap football stadiums. There is an environmental cost to getting the beer to the glass, in energy for cooling the beer store, for chilling the beer dispense equipment, for cleaning each beer line using clean water and for each line clean many Liters of strong chemicals are poured down the drain. Technik2 have worked alongside main brewers with the aim to reduce costs, to reduce the impact on the environment, there are 3 main areas that need improvement. 1, Beer cooling. Beer cooling has always been a hidden cost, with low cost high energy coolers and chillers used throughout the industry. These units have no intelligence or the ability to change temperatures from beer serving hours to dormant times. Technik2 have designed units that are installed onto such equipment to make them highly energy efficient by giving them intelligence so reducing wasted energy. 2, The beer dispense equipment. This again has not changed over the last 100 years, and still using the same parts and valves throughout the industry. Today with modern equipment such as electron microscopes and new polymers Technik2 have identified the key bacteria that makes the beer” go off” or gassing called foam on beer (FOB). Using Technik2s new self cleaning materials there is a 95% reduction in bacteria growth. 3, The line cleaning process. Technik2 have been monitoring line cleans both by bar staff and managed cleans (by the brewery) and found vast differences in the quality of the cleans. The problem is the chemical company or brewery instructions are not being followed, the result is a bad clean that leaves bacteria inside the lines. Technik2 have designed equipment to profile in real time the line clean that also measures the quality of the clean from start to finish. Bringing all the new products to the market will vastly improve the quality of the beer in the glass

Keywords: avoiding fobbing,bio polymer,cellar,improved energy efficiency,remote monitoring system,line cleaning,quality beer,sustainable hospitality,resources efficiency,beer dispense system
Re-designing the construction sector: Sustainable and functional bio-based construction products and building elements (BIOS MATER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Spain,Greece,Ireland,Belgium,Netherlands,Cyprus,Italy,Germany,Portugal,Serbia
Call: Circular and SSbD bio-based construction & building materials with functional properties (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 9650180.0
EU funding (EUR): 7463260.0
Participants: 22
Project status: SIGNED

The BIOS MATER aims to develop and demonstrate advanced bio-based construction products and building elements with tailored functional properties such as durability, fire resistance, water barriers, acoustic and thermal insulation, lightweight structure, mechanical strength, and antimicrobial features, ensuring safety and sustainability. At the core of the concept are the four Production routes which are built around four pillars. Specifically: Production route A will focus on the development of bio-based core product and sandwich structure for flooring applications, Production route B will focus on the development of bio-based wall panels and flooring tiles, Production route C will focus on the development of fiber reinforced bio-resin composite panels applied as exterior façade cladding panels and Production route D will focus on the development of biodegradable and plantable bio-based tiles from foams applied as drywalls panels. Moreover, the four pillars are: Pillar 1. Innovation in bio-based construction and building product development; Pillar 2. Health, safety, and environmental impact through Safe and Sustainable by Design (SSbD), Pillar 3. Circular economy integration and scalability and Pillar: 4 Driving market adoption of bio-based products through digital transparency, stakeholder engagement, and social acceptability. Key elements include life cycle assessments (LCA), circularity, and SSbD assessments. BIOS MATER will test and demonstrate the compatibility of these products with existing construction practices and regulatory frameworks at the controlled real-world application of a DEMOpark. The project also incorporates stakeholder engagement, training, and awareness programs, with 22 partners from 10 EU countries working together to achieve these goals across 7 work packages.

Keywords: sustainable and circular bio based construction circular economy co2 emissions reduction safe and sustainable by design life cycle assessment construction and renovation innovation
INnovative INtegral approach for WOOD waste depollution and multi-sector valorization (WoodTreat)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Sweden,Germany,France,Greece,Italy,United Kingdom,Netherlands,Belgium,Albania,Cyprus
Call: Valorisation of polluted/contaminated wood from industrial and post-consumer waste streams (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 3542200.0
EU funding (EUR): 3500000.0
Participants: 21
Project status: SIGNED

According to today’s practice, wood waste is roughly classified into three or four classes, depending on the country. The most polluted grade, often referred to as grade C or AIII/AIV, consists of preservative-treated wood, i.e. wood that has been impregnated with chemicals (pesticides, biocides and fungicides) to enhance its bio-resistance. Grade C or AIII/AIV is not currently recycled. The increased use of wood as encouraged by initiatives like the New European Bauhaus is likely to require additional volumes of preservative-treated wood. Even though such treatments extend the service life of wood products, they will still eventually become waste and must be dealt with. Wood preservation compounds pose a significant threat to not only the environment but also to human health, and therefore it is needed to develop efficient remediation technologies. At the same time, current recycling processes are greatly complicated by the presence of pollutants (chemical treatment products, heavy metals), which calls for further research on cleaning methods. As grade C comprises of several types of wood types and products, along with different levels of contamination, this poses a complex problem that needs action from both the circular economy and non-toxic environment fields. The development of an automated on-line characterization system to distinguish chemically contaminated wood waste has become a high priority. Gaps in existing regulations should be considered as may not fully support the use of upcycled wood materials from such waste streams. IN2WOOD proposes a multi-dimensional cascade approach for highly polluted post-consumer wood waste via a series of seven Pilot Validation Trials (PVTs) with aim to reduce the demand for virgin materials, reduce unsustainable options such as landfilling or incineration, and support the transition towards a circular economy by developing new value-added products from clean secondary materials.

Keywords: grade c waste creosote preservatives neutrons steam explosion bioremediation green extraction cellulose lignin fibres insulation panels adhesives,wood composites mfc clay bricks ssbd
City tales: an art-based participatory framework for studying migration-related diversity (ARTIVES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands,Portugal
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2029-09-30
Duration (months): 69.0
Total project cost (EUR): 1499353.0
EU funding (EUR): 1499353.0
Participants: 2
Project status: SIGNED

This project will study imaginaries of diversity portrayed by Afro-European artists in Lisbon and Rotterdam in their films, performances and (oral) stories. These stories are not sufficiently related to in the mainstream discourses and the hypothesis is that the arts offer a particularly vibrant textual weft for exploring competing imaginaries of postcolonial urbanity. The two European ports are chosen since they position themselves as ‘open-to-the-world’ in light of their maritime history and ensuing migration dynamic. Yet they significantly differ in the ways that their municipalities frame their multiculturalism. I will build the framework of ‘urban artives’ – archives of situated stories – to explore non-essentializing conceptualizations of migration-related diversity. By close reading creative forms of storytelling; interviewing and following artists in their city wanderings; digitally mapping spaces of inspiration, production, and performance; and producing two creative outputs, ARTIVES will 1) trace transnational networks of belonging embodied in the local cultural scene and 2) test the possibilities and limitations in relating to these stories in ways that break away with ‘migrantising’ (Wiest 2020) conceptions of society. This research will transpose recent developments in the field of Critical Archival Studies, namely attempts to account for the transitory nature of identity formation in records’ preservation, to the fields of qualitative culture-oriented Urban Studies and Migration and Transnationalism Studies. In this way, ARTIVES will bridge the symbolic, material and affective aspects of how urban communities realize their sense of belonging and claim agency within highly diverse cities. Furthermore, the project will offer a best practice for working with community-driven knowledge contributing to the ongoing debate in Cultural Anthropology and Cultural Studies on how power relations are implicated in participatory research.