Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Super-Resolving Quantum Imaging and Detection (SURQUID)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Sweden,Belgium
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 3759480.0
EU funding (EUR): 3759480.0
Participants: 7
Project status: SIGNED

Imaging and remote sensing protocols in the classical domain are fundamentally limited by the diffraction limit and detection noise. To move beyond these boundaries photonic quantum technologies provide new paradigms for achieving unprecedented sensing performance. The SURQUID project will achieve both super-resolution below the Rayleigh diffraction limit and super-sensitivity below the shot noise limit for light detection and ranging (lidar) applications. Using quantum homodyne detection (QHD) combined with non-classical illumination using entangled coherent states (ECS) we will realize a quantum lidar system for multi-scale quantum imaging with unparalleled accuracy and precision. We will implement a long-term stable QHD system by integrating multiple superconducting single photon detectors (SNSPDs) in nanophotonic circuits. Operation in the telecommunication spectral window, where atmospheric transparency is high, will enable remote quantum imaging on a logarithmic length scale from 100 mm to 100 km distances. Waveguide-integrated SNSPDs excel in performance in the telecom wavelength range and provide a scalable route towards multi-wavelength and multi-detector architectures. We will implement a two-color quantum lidar system where time-of-flight (TOF) detection with ultralow timing jitter below 10 ps on one wavelength will give information about target distance with 2 mm accuracy, while QHD combined with ECS illumination on a second wavelength will provide quantum-enhanced local spatial resolution. Through beam scanning and synchronized QHD we will realize super-resolved surface profiling. Our consortium is uniquely placed to tackle these challenges by joining leading experts in ultrafast single photon detection, nanophotonic circuit design and quantum light generation. The SURQUID project will realize a ready-to-use quantum lidar system for applications in super-resolved object identification, remote sensing and quantum enhanced imaging.

Keywords: quantum technologies,nanotechnology,quantum sensing,lidar,superconducting single photon detectors,entanglement,photonic integrated circuits,silicon photonics
A Compact Dynamic Positioning System of General Purpose for Marine Units, Crafts and Ships (General Purpose DP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Operation of floating units in the sea often requires the units to maintain position, as for instance in the rescue after a ship wreck or when assisting a wind farm. Due to the stochastic behaviour of the sea, Dynamic Positioning (DP) Systems accurately automate this task reducing the risk of human error. However, current DP1 systems in the market evolve from those used in the Oil&Gas, which are highly redundant and expensive. Seaplace has designed seaDP-1C, a DP1 System with the operator station and the real time controller in a single CRIO 908X unit. This compact system is cheap, robust, requires little space, and provides great flexibility due to its modularity. Our DP will come with a smart green autopilot, which, by filtering waves, corrects accurately the drift course, reducing consumption by 1 to 3%. With SeaDP-1C we will generalize the use of smart control and manoeuvring, offering an affordable product and reaching the niche market of the most technological units. As a naval architecture firm with 34 years of experience, Seaplace knows many different players of the marine sector interested in seaDP. Shipyards and yacht manufacturers can choose the provider of a system among those approved in the maker’s list, and ours will offer a great price. Providers of propulsion systems and electronic installations without DP will use the modularity of our system to offer turn-key projects. Shipowners without DP will also install our system because of its price and consumption reduction. In Phase 1 we will confirm the costs, the market opportunity and plan the implementation. In Phase 2 we will build and check the real product, install it aboard, and get the Class Approval so that we can start selling it, which will convert us onto a high-growth company: in the 3rd year our turnover will increase by 6 million €. Through our system the EU will get a feasible way to increment the safety at sea, allow more efficient operations and minimize fuel consumption and emissions.

Keywords: smart control and manoeuvring green modular compact dynamic positioning system and autopilot
New frontiers in advanced glycotherapy for cancer (GlycoTherapy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 2150000.0
EU funding (EUR): 2150000.0
Participants: 1
Project status: SIGNED

Cancer remains a major cause of death despite phenomenal progress in current immunotherapy, that aims to boost host immune responses of antibodies and T cells, and their ability to distinguish cancer from normal cells. The three main cancer immunotherapies are therapeutic cancer vaccines, cellular therapeutics and immune checkpoint blockade, but those have only limited success mainly due to difficulties in identifying target antigens. Carbohydrate chains (glycans) ubiquitously occupy surface of cells, but on cancer they are aberrantly-expressed, in particular with a wide collection of sialic acid-glycans. Their antigenic complexity arise by sialic acid structure modification, linkages, length, protein/lipid scaffolds, surface organization and density. The presentation mode of glycans and their heterogeneity affect their immune recognition, but the fundamental knowledge of how these factors contribute to efficient cancer therapy in vivo has not been defined systematically. The primary objective of this proposal is to design a comprehensive novel cancer immunotherapy approach targeting glycan-neoantigens. We propose an innovative interdisciplinary approach that integrates glycobiology, immunology and nanotechnology, to design and fully investigate new frontiers in cancer ‘GlycoTherapy’ in vivo. Our discovery line is based on a two-arms modular platform to study both engineered carbohydrate-cancer vaccines and T cells, and their combined effects with checkpoint blockade on therapeutic glycan immune recognition in mouse models. Efficacy will be evaluated in detail by systematic characterization of immune cell and humoral responses with cutting-edge tools, including glycan microarrays, to track response repertoire and kinetics. Successful establishment and in-depth understanding of these therapies will provide a platform to devise and validate potent novel glyco-cancer diagnostic tools and therapeutics, and will instigate their prospective clinical translation in humans

Keywords: sialic acid,neu5gc,cancer carbohydrate antigen,neoantigen,antibodies,chimeric antigen receptor car t cells,cancer,nanotechnology,cancer vaccine,checkpoint inhibitors,immunotherapy
The EDUCAGE: A Behavioral Platform for Naturalistic Learning (EDUCAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Understanding behavior is still one of the holy grails in the natural and social sciences. Behavior is often utterly complex because it is a result of an extremely rich set of past experiences, the present state of the animal and the animal’s predictions about the future; all of which affect learning, decision making and consequently behavior. Given the complexity of behavior, most researchers work in the realm of highly simplified learning tasks but these only test very basic attributes of learning and are constraining discovery of more sophisticated behavior. To date, there are only few available platforms for rigorous study of complex behavioral paradigms in experimental animals; not in basic science nor in biomedical research. Our goal is to bring to completion (and potential commercialization) a novel platform for analyzing complex animal behavior named “The Educage” to allow fully automatic, hands free assessment of higher cognitive functions in freely behaving animals. Potential customers are research labs, and the biomedical industry. The Educage will allow researchers to study behavior at unprecedented resolution, 24/7, for any duration of time. The learning paradigms can be tailored to the specific task of interest. The Educage has many advantages that outperform existing technologies by allowing rigorous statistical assessment of complex behaviors in laboratory animals. The Educage allows researchers the flexibility to monitor, analyze and manipulate the experiment during the behavior. Our system can be reliably used to analyze perceptual learning in mice and is well suited for being a new and rigorous behavioral platform. It has great potential to become a central tool to fuel discovery in animal research both in biology and biomedical research.

Keywords: behavior,learning,automated,natural,perception,auditory,olfactory
The ultimate solution for modern electricity grids (PowerGRAB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 2968870.0
EU funding (EUR): 2061603.25
Participants: 1
Project status: CLOSED

POWERGRAB is a unique technology on the high voltage market. It is the only high-voltage grid surveillance system that includes an energy harvester that attains enough electricity (100 times more than current available options) to deliver direct current (DC) power. This power enables an avant-garde high-quality real-time internal and external surveillance and measurement devices (high-resolution 360º camera with night vision, thermal camera, accelerometer, salinity sensors, weather stations, tilt sensors, real-time communication). The patented technology [US 10,622,838] easily clamps onto any alternating current (AC) carrying phase wires of high voltage power lines and harvests this energy from the surrounding electromagnetic field, powering the surveillance equipment located in its weather-sealed compartment. This solution provides real-time detailed insight on the grid status to operators, enabling better management of the characteristic intermittence of renewable energy generation and its infrastructure and ensuring, safety, cost-efficiency and optimal performance and maintenance of the infrastructure, as the challenges of increased renewable energy production and smart grids evolve. We have installed two prototypes of the system on high voltage power lines in Iceland for real-time testing, in collaboration with Landsnet, the Icelandic transmission system operators (TSO), and one prototype in Norway in collaboration with Statnett, the Norwegian TSO. The results of these live tests are serving as inputs for product development. LAKI POWER was founded in 2015 with the objective to disrupt the way monitoring of high voltage lines is carried out by providing cost effective real-time intelligence to operators. The strategy is to build on and add value to our unique power platform and become a provider of full-service surveillance systems.

Keywords: on line generator,electricity line monitoring,power harvesting
Nucleocytoplasmic O-glycosylation in Yeast (Yeast-Glyco)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 278227.8
EU funding (EUR): 278227.8
Participants: 2
Project status: CLOSED

Signal transduction via post-translational modifications (PTMs) of proteins maintains essential cellular processes in all eukaryotes. Similar to protein phosphorylation, O-GlcNAcylation is a vital signaling mechanism that involves the dynamic cycling of sugar molecules on proteins and these PTMs exhibit extensive crosstalk for regulation of core cellular processes. The only eukaryotic cell type that lacks both signaling mechanisms is yeast and it has been difficult to understand how yeast survive without the essential functions of O-GlcNAcylation. This proposal is based on our discovery demonstrating that baker’s yeast has an O-linked mannose (O-Man) glycosylation system that operates in nuclear, cytoplasmic and mitochondrial compartments. The localization of these O-Man modifications on yeast proteins mirrors that of O-GlcNAcylation found in higher eukaryotes and this discovery demonstrates that yeast possess a hitherto unknown signaling mechanism involved a myriad of cellular processes. This research project aims to explore when and where yeast utilize the nucleocytoplasmic O-Man signaling system and to understand the functional consequences of this novel modification. In addition, the project aims to identify and characterize the enzymes responsible for the attachment and removal of nucleocytoplasmic O-Man modifications in order to enable manipulation of the system for improvements in yeast-based bioproduction and bioprocessing platforms. The project will open an entirely new area of research by bringing novel knowledge on how yeast orchestrate cellular signaling and advance our understanding on how essential cellular processes are controlled in eukaryotes. This holds promise to bring unique opportunities to manipulate yeast for improvements and open for wide applications in industry and biotechnology.

Keywords: glycoproteomics,o glycosylation
Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response. (ONCOBIOME)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Italy,Italy,Italy,Germany,Sweden,France,France,France,France,Czechia,Netherlands,United Kingdom,Canada
Call: Exploiting research outcomes and application potential of the human microbiome for personalised prediction, prevention and treatment of disease (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 15041511.25
EU funding (EUR): 14994551.25
Participants: 23
Project status: SIGNED

Beyond the role the intestinal metagenome plays in regulating multiple physBeyond its role in regulating multiple physiological functions that impact health, the intestinal metagenome is implicated in cancer initiation, progression and responses to therapies, even for extraintestinal neoplasia. Hence, there is an urgent need to fully identify and functionally characterize minimalist commensal ecosystems relevant to cancer, with reliable and robust methods, to validate cancer-associated gut microbiome fingerprints of high clinical relevance, and to develop diagnosis tools that will become part of the oncological arsenal for the optimization and personalization of therapy. Based on retro-and pro-spective studies, with large discovery and validation cohorts enrolling >9,000 cancer patients across 10 countries, ancillary to ongoing innovative clinical trials or FDA/EMA approvals across 4 frequent cancer types, ONCOBIOME will pursue the following aims: 1/ identify and validate core or cancer-specific Gut OncoMicrobiome Signatures (GOMS) associated with cancer occurrence, prognosis, response to, or progression on, therapy (polychemotherapy, immune checkpoint inhibitors, dendritic cell vaccines) or adverse effects, 2/ decipher the functional relevance of these cancer-associated gut commensal ecosystems in the regulation of host metabolism, immunity and oncogenesis, 3/ integrate these GOMS with other oncology hallmarks (clinics, genomics, immunomics, metabolomics) 4/ design optimal companion tests, based on those integrated signatures to predict cancer occurrence and progression. With high carat interdisciplinary experts, ONCOBIOME expects to validate cancer or therapy-specific Gut OncoMicrobiome Signatures (GOMS) across breast, colorectal, melanoma and lung cancers adjusting for covariates, to unravel the mode of action of these GOMS in innovative platforms, thus lending support to the design of cancer preventive campaigns using well characterized pre-and pro-biotics.

Keywords: breast cancer,colon cancer,melanoma,lung cancer,microbiome,cancer,molecular fingerprints,diagnosis tests,assays,prophylactic measures,precision medicine,prophylaxy,immunotherapy,immune che
EPICA - Strategic partnership for the co-design of an innovative and scalable eportfolio ecosystem to improve the quality and visibility of skills (EPICA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Uganda,Germany,Tanzania, United Republic of,Norway,Kenya
Call: International partnership building in low and middle income countries (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2020-12-31
Duration (months): 36.0
Total project cost (EUR): 2170675.0
EU funding (EUR): 1897450.01
Participants: 8
Project status: CLOSED

Technology is driving change in Africa and knowledge has become a key driver of growth and development. Moreover, education needs to meet the demands of the work place and provide the skills and competencies needed to foster local economies. However, a severe mismatch exists between the skills of young workers and the skills that employers need for the emerging economies. EPICA (Strategic Partnership for the Co-design of an Innovative and scalable ePortfolio ecosystem to improve the quality and visibility of skills) aims to contribute to address this skills-gap through a process of co-design, adaptation, implementation and validation of an innovative and scalable Competency-Based ePortfolio, with an international partnership that includes industries, leading educational organisations, four universities in three Sub-Saharan countries (Open University of Tanzania, Makerere University from Uganda, Maseno University from Kenya, and the African Virtual University) and one EU University (Open University of Catalonia). EPICA’s outcomes will support: • Universities to deploy and implement the new Competency-Based pedagogical methodologies to face the increasing market demands in term of better-skilled workers • Students (and workers) to make more visible and comparable their skills and competencies acquired in formal and non-formal education • Employers and companies to identify the most reliable and suitable candidates With a market-oriented approach, EPICA involves end-users’ communities in the whole process to ensure that the ePortfolio meets users’ and market’s requirements. The pilot in four universities (MAK, OUT, MU, UOC) and the Validation phase will provide the data for evaluating end-users’ behavioural responses, and the means to build a robust and sustainable model, the “ePortfolio implementation Pack” (technology-consultancy-support), to ensure take up and scalability, by involving local Sub-Saharan companies and HUBs in the commercialisation process.

Keywords: e learning,competency based learning,eportfolio,scalability
Ribosomal frameshifts as a novel mechanism to control RNA turnover in stress (TERMINATOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

Modulation of gene expression is key for maintaining cellular homeostasis in the changing environment. It is achieved through controlling the processes of transcription and RNA degradation that ultimately affect abundance and composition of the mRNA pool. Emerging evidence suggests that the pathways of RNA surveillance and degradation are of paramount importance for fast adaptation of gene expression to stress. One of the most studied mechanisms controlling RNA turnover is nonsense-mediated decay (NMD). It eliminates erroneous transcripts containing premature termination codons (PTC), and also regulates expression of functional transcripts in condition-dependent manner. Recently, my host lab has demonstrated existence of widespread coupling between mRNA decay and translation. This opens a new window for translation dependent regulation of RNA turnover. Specifically, recent studies show that ribosomal frameshifts (RF) occurring during translation induce PTCs and fire NMD response. Preliminary evidence from the host lab suggests that RF is regulated upon stress and could serve as a new mechanism to sense environmental signals and adapt mRNA concentrations. It is yet to be tested if such a regulation is of widespread nature in the cell. The main goal of this project is to investigate stress-dependent regulation of ribosomal frameshifts and their role in RNA turnover. The 5PSeq approach developed in the host lab will allow for performing high-scale analysis in yeast and human cells, and overcoming existing technological challenges previously limiting research in the field. This project will also explore the cross-talk between RNA turnover and telomere maintenance in cellular response to stress and aging. This will expand the accumulated evidence suggesting interconnection of RNA turnover with other processes involved in cellular adaptability. Finally, I will develop a software package for analysis of RNA degradation datasets that can be used by the research community.

Keywords: rna degradation,nonsense mediated decay,ribosomal frameshifts,stress,telomere maintenance,ageing,sequencing data analysis software