Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cyclometallated ruthenium complexes for photo-activated chemotherapy (CylcoRu4PACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Chemotherapy is efficient in curing cancer, but most treatments are very hard to stand for the patient, and side effects limit treatment efficacy. Phototherapy is a promising alternative, where the toxicity of a light-sensitive chemotherapeutic compound is locally released upon visible light irradiation of the compound-containing tumour. Photodynamic therapy is already available in the clinic for oxygen-rich tumours; however, it fails when the oxygen concentration at the place of irradiation is too low. In this project I propose to synthesize new ruthenium-based photochemotherapeutic compounds containing cyclometallated ligand, and to test them in an in vitro model of hypoxic cancer. The presence of a carbon-metal bond is known to shift the light absorption properties of ruthenium polypyridyl complexes towards the photodynamic window, a wavelength range where light penetrates optimally into biological tissues. However, cyclometallation usually quenches the ligand photosubstitution properties of ruthenium compounds because it strongly modifies the energy of their excited states. In this project, I will introduce sterically hindering groups on the cyclometallated ligand to recover photoreactivity of the complexes while keeping light absorption at high wavelengths. The challenges of this project consist on the one hand in achieving efficient ligand photosubstitution reactions with cyclometallated ruthenium compounds, and on the other hand in minimizing the cytotoxicity in the dark while maximizing cytotoxicity after red light irradiation at low oxygen concentrations. The ruthenium prodrugs will be synthesized, their photochemical properties will be measured, and their cytotoxicity against human cancer cell lines will be determined in an in vitro model of hypoxic cancer. This project will set new grounds in the treatment of hypoxic tumours and propose a new way to overcome side effects occurring in traditional anticancer chemotherapy.

Keywords: ruthenium,cytotoxicity,chemotherapy,phototherapy
Holistic Optical Metrology for Aero-Elastic Research (HOMER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,France,France,France,Netherlands,United Kingdom
Call: Maintaining industrial leadership in aeronautics (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-09-01
End date: 2022-02-28
Duration (months): 42.0
Total project cost (EUR): 4914391.25
EU funding (EUR): 4910641.25
Participants: 9
Project status: CLOSED

HOMER is aiming at the development of non-intrusive experimental flow diagnostic and data assimilation methods to expand capabilities from the aerodynamic analysis to the investigations of fluid-structure-interactions (FSI) in wind tunnels and other test facilities. The objective of the project is to develop an unattained combined diagnostic approach with simultaneous optical measurements of fluid and structure. When this is achieved, the measurements can be treated invoking the relation between the balancing forces (inertia-, elastic- and aerodynamic forces) interacting (non-linearly) within the s.c. Collar Triangle (FI + FE + FA = 0). The research focuses on the application and further development of time-resolved volumetric (4D) flow field measurements that enable determining the fluid flow pressure. 3D PIV and Lagrangian Particle Tracking (LPT) along with Digital Image Correlation (DIC) are tailored to determine the position and dynamics of fluid and surface motion and deformations. Pressure Sensitive Paint (PSP) methods will be employed simultaneously with DIC and PIV/LPT to obtain the surface pressure at transonic flow velocities together with the model deformation. The project realizes experiments that support the validation needs of MDO tool developments, enhance the physical knowledge about Fluid-Structure-Interaction phenomena and range from the assessment of the method (turbulent flow over a deforming surface) to relevant problems in aeronautics (transonic buffeting) and flapping flight mechanics.

Keywords: aeroelasticity,pressure,loads,fluid strucure interaction,flapping wings,transonic flutter,collar triangle
Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease (Foie Gras)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Germany,Spain,Italy,Poland,France,Czechia,Portugal,Portugal,Denmark,Portugal,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3202195.68
EU funding (EUR): 3202195.6799999997
Participants: 14
Project status: CLOSED

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of non-alcoholic fatty liver disease (NAFLD). Its progression to nonalcoholic steatohepatitis (NASH) is a leading risk factor for development of Type 2 diabetes, cirrhosis, and hepatocellular carcinoma. FOIE GRAS is first in supporting a cohesive and synergistic intersection of complementary and interdisciplinary training skills from academic and non-academic partners. FOIE GRAS combines strong scientific expertise with integrated and complementary training in translational research, clinical practice, technology commercialization, and public outreach, the combination of which in targeting NAFLD is lacking in the EU. Industrial partners CETICS, Mediagnost and Seahorse Biosciences provide experience on technology commercialization alongside scientific contributions while the affiliated patient organization will contribute with important training in societal awareness topics. ESRs training will utilize network-wide workshops and secondments to foster translation of basic research to clinical applications and SME creation. This diverse yet integrated skill set enhances the employment prospects of the trained researchers in both academic and non-academic sectors. Researchers will be endowed with excellent basic scientific knowledge and timely technology transfer know-how for developing novel therapeutic approaches for reversing the burden of NAFLD, thereby advancing both health and economic well-being of European citizens and approaching NAFLD research in the EU from its counterparts in the US and Asia.

Keywords: fatty liver disease,metabolism,liver,mitochondria,biomarkers,science awareness,communication
Artisan pedagogies: investigating craft experts as educators (ARPED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2025-05-02
Duration (months): 36.0
Total project cost (EUR): 304724.16
EU funding (EUR): 304724.16
Participants: 1
Project status: SIGNED

How do artisans approach their role as educators? As part of long-standing research on world craft practices and their social, cultural, and economic dimensions, anthropologists have been paying attention to processes of learning: how aspiring practitioners acquire skills and know-how through participation in social settings. The influence of these studies extends well beyond the boundaries of anthropology, to inform research in the social sciences of learning. Within this research, scant attention has been given to the perspectives of artisans, who are not just skilled practitioners but also often skilled educators. To redress this, this project proposes to develop the concept of artisan pedagogies, to denote the skills and understandings that artisans develop through the practice of teaching and mentoring novices. It will do so by taking social interactions in the context of practice-based learning as its focal point of investigation, and recognising that diverse forms of craft provide unique perspectives onto learning. The research develops an innovative and inter-disciplinary methodology, combining sociolinguistics (conversation and interaction analysis) approaches with ethnographic methods (participant observation, apprenticeship as method). It deploys a participatory approach to elicit artisans’ implicit understandings about how novices learn, and implicit work and social ethics. The methodology will be applied to two empirical case studies addressing dry-stone masonry in Switzerland and Taiwan, allowing for a comparative dimension based on exploration of pedagogies in relation to procedures, culture and the environment. The study will lead to re-evaluating key theories and concepts in the anthropology and social sciences of learning, in light of expert practitioners' own understandings and practices.

Keywords: craftwork,enskilment,sociality
exPerimental And Numerical mulTiscale mulTiphasic Heat ExchangeR (PANTTHER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Belgium,France
Call: Vapor Cycle System - Heat Exchanger performance 3D modeling with different new low GWP refrigerants (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 1196128.75
EU funding (EUR): 1196128.75
Participants: 2
Project status: SIGNED

exPerimental And Numerical mulTiscale mulTiphasic Heat ExchangeR Heat exchangers have a fundamental role in aviation engineering. Heat echanger development is ever in progress, to reduce the heat exchanger volume and to enhance the performances. Although the F-gas II regulation does not yet apply to the aeronautical field, actions are being taken by the entire industry to reduce the environmental footprint of air traffic and investigate the use of low GWP refrigerants. Currently, multiphasic heat exchanger headers have mainly been designed and optimized with an empirical approach and an experimental validation. And the multiphasic heat exchanger core is up-to-now designed with experimental-based correlations, all obtained with the high GWP fluids. PANTHER project totally fits in the breakthrough requirements, taking advantage of the new optimization strategy of headers coupled with innovative CFD models of the heat exchanger core. The greatest strength of the PANTHER project is close collaboration of the CFD model development together with the experimental facilities for an optimum validation. PANTHER project will carry out numerical simulations to optimize multiphasic heat exchanger performances: through a 3D CFD porous media model taking into account phase change phenomena and fin structures. For the optimization, topological optimization and adjoint methods will be assessed. To validate the developed CFD models, PANTHER will design, construct, and characterize and two experimental facilities; • The adiabatic experimental set-up will validate the adiabatic multiphasic porous media model • The multiphasic experimental set-up will validate the multiphasic porous media model with heat and mass transfer model, and validate also the optimization chain methodology. The facility will work with an air mass flow range of 0.01 kg/s to 0 0.5 kg/s, an air temperature range of [-10:60°C], refrigerant flow range up to 80 g/s. The chosen fluid for testing is R1234ze.

Keywords: compact heat exchanger,refrigerant,evaporator,optimization
Centre of Excellence for Advanced Technologies in Sustainable Agriculture and Food Security (ANTARES)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Serbia,Serbia,Netherlands
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 433720.0
EU funding (EUR): 433720.0
Participants: 4
Project status: CLOSED

Agriculture and food security are one of the main focal points of EU policies, since,in the next 20 years, world food production must increase by 50%, while 80% of that increase must come from intensification (Source: FAO). ANTARES aims to evolve BioSense Centre at the University of Novi Sad, Serbia, into a European Centre of Excellence (CoE) for advanced technologies in sustainable agriculture and food security. This endeavor is supported by the participation of the Serbian Ministry of Education, Science and Technological Development (MESTD), the national research authority who will provide both institutional and legislative expertise as well as co-financing of 14 mil Euro. The participation of DLO, the Netherlands, the leading European research institute for applied and market-driven research in agriculture and food security, currently involved in 250 FP7 projects, will secure that the know-how and experience of highest European standards are transplanted to Serbia. ANTARES envisages a long-term and mutually beneficial strategic cooperation between DLO and the new CoE, by exploiting the competitive advantages of both organizations. The project relies on the principles of continuity (by capitalizing on the achievements of BioSense), evolution (by identifying the gaps and implementing actions to address them), and consensus (by incorporating the needs and expectations of stakeholders in the vision and strategy of the new CoE), to engage the region in a path of innovative growth. ANTARES is perfectly aligned with the regional innovation priorities as presented in the Smart Specialization Strategy of Vojvodina, while its impact in innovation, economic development, and sustainability is expected to spread at a much broader national and European level.

Keywords: centre of excellence,advanced ict technologies,sustainable agriculture,food security
Intensified by Design® for the intensification of processes involving solids handling (IbD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Germany,Italy,Spain,Switzerland,Finland,Finland,Norway,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Solids handling for intensified process technology (H2020-SPIRE-2015, 2015)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 10986652.9
EU funding (EUR): 8484489.14
Participants: 26
Project status: CLOSED

IbD® will create a holistic platform for facilitating process intensification in processes in which solids are an intrinsic part, the cornerstone of which will be an intensified-by-design® (IbD). The IbD approach is hinged on the use of robust data about a process to ‘redesign’, modify, adapt and alter that process in a continuous, intensified system, and will be the new paradigm in the intensification of processes based on statistical, analytical and risk management methodologies in the design, development and processing of high quality safe and tailored chemicals, pharmaceuticals, minerals, ceramics, etc. under intensified processes. The IbD Project will deliver the EU process industry with an affordable and comprehensive devices-and-processes design-platform endeavoured to facilitate process intensification (PI), which specially targets -but is not limited to- solid materials processing. Five PI industry case studies will be implemented in mining, ceramics, pharmaceutical, non-ferrous metals and chemical processes using the IbD approach and to validate the IbD methodologies, tools, PI modules, control and fouling remediation strategies and the ICT Platform itself for the industrial implementation of PI in processes involving solids. The Platform includes design modules for the commonest intensified reactors-Rotating fluidized beds, micro-structured reactor and spinning disk, among others, as well as a generic Module Builder -equipped with a set of both proprietary and third-parties design tools- for designs carried out on the basis of radically novel ideas. The IbD Platform output is basically a data set that comprises the intensified reactor design -ready to be built or assembled-, an optimised whole process design including the upstream/downstream intensified unit operations and their solids handling capability, as well as cleaning methods, etc. and the expected economic and environmental quantitative impacts.

Keywords: process intensification,process intensification methodology,chemical process design tools,numerical tools,pi modules,industry case studies
Urban networks: multidisciplinary research into the formation of early urban societies in Campania (Italy) (URBANet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Living in cities has been one of the most transformative innovations in human history: it has heavily impacted social and political interaction between people, and has significantly changed the relationship between man and his natural environment. Understanding why people in the past started living together in cities in the first place, provides crucial tools for the study of urban life from a comparative perspective. One of the earliest urbanised regions of Europe was Campania, in Southern Italy. The first traces of urbanisation date to the early first millennium BCE. Innovative archaeological research on urbanisation in Campania is still lacking. With the URBANet project, I propose an innovative approach to early Campanian urbanisation, informed by multidisciplinary perspectives. I start with the specific hypothesis that the processes underlying the formation of early urban societies in the past were social and political. At the same time, the topographical component was fundamental. Furthermore, early urban societies interacted with each other. This observation suggests, in addition, that urbanisation also rose as the result of connectivity and networks. I propose to verify the hypothesis with the collection and analysis of data, focusing on four selected case-studies. The innovative method combines qualitative (anthropological) methods with computed analysis (GIS and social network analysis). Training goals are set to bolster my research and project management skills. The expertise at the VU University in similar projects ensures the best possible institutional environment for the execution of the URBANet project.
Signals, Waves, and Learning: A Data-Driven Paradigm for Wave-Based Inverse Problems (SWING)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1986430.0
EU funding (EUR): 1986430.0
Participants: 1
Project status: SIGNED

Scattering of waves governs fundamental questions in science, from imaging molecules to fine-tuning concert hall acoustics. Efficient scattering computations rely on sparse representations of wavefields. Spurred by the empirical successes of deep learning, the emphasis has recently shifted to data-driven modeling. However, unlike signal-theoretic implementations that come with sharp approximation guarantees, it remains unclear whether the popular deep learning structures can represent important scattering operators. In SWING, we address this question by leveraging advances in signal processing and machine learning. We propose theory and algorithms for the upcoming, learning-based wave of breakthroughs in forward and inverse scattering. SWING is built on three research thrusts: 1. To design efficient computational structures with approximation guarantees for learning scattering operators. We will focus on minimal structures for Fourier integral operators which model key problems. 2. To treat learning for inverse scattering as a sampling problem and derive practical sample complexity results. We will explore connections between learning theory and stability of inverse problems, and examine the regularization roles of data, physics and nonlinearity. 3. To apply our techniques to two classes of inverse problems: (i) emerging modalities in molecular imaging, giving rise to problems in geometry and unlabeled sampling; and (ii) seismic tomography of Earth and Mars, with data-driven discretizations of scattering operators playing a central role. With the growth of wave-based sensing, there is an urgency to quantify the limits of the data-driven paradigm in scattering problems. The power of data in fitting models is indisputable: it is certainly the next frontier. We believe, however, that the best designs combine data-based models with an understanding of the underlying physics.

Keywords: wave equation,inverse problems,scattering,inverse scattering,machine learning,deep learning,multiple scattering,geophysics,seismic imaging,molecular imaging,cryoem,free electron laser,fourier integral operators,layer peeling,recurrent neural networks,diffeomorphisms