Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
On-animal sound sensors: long-term sound and movement recording tags for studying how environmental noise affects animals (ANIMALSOUNDSENSORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A vast array of animals use sound to communicate, find food or detect threats. But vocal and hearing systems that evolved over millions of years must now contend with noise from human activities that are radically changing sonic environments world-wide. The problem may be particularly acute in marine ecosystems where low attenuation of sound increases the footprint of noise sources. Studies to measure how noise affects animals have suffered from a lack of observational tools. An important advance has been the development of multi-sensor tags that record the sounds experienced by animals and their movements. Field studies with tags on cetaceans have demonstrated surprisingly strong responses to single noise exposures but the short 1-2 day duration of current tags makes it impossible to evaluate their biological significance. Here I propose to develop a unique experimental capability to test if responses to noise can have a cumulative impact on fitness. To achieve this, I will create a highly-integrated tag capable of recording sound, foraging motions and locomotory effort of individual animals over months. Using this device, I will team with experts in field studies on three taxa: seals, echolocating whales, and deer, to quantify the long-term exposure to human-sourced sound and its behavioural and energetic consequences. The different sensory systems, environmental constraints and strategies of these taxa will help in interpreting how and to what extent noise can change foraging rates and so impact fitness. In the final phase of the project, I will miniaturize the tag for use on small terrestrial animals and birds to examine the role of predation pressure in shaping noise responses. The project will pair cutting-edge electronic technology with European leadership in field studies of wild animals to create a world-first capability that will provide scientific guidance for marine conservation while also addressing emerging noise concerns in terrestrial animals.

Keywords: behavioural biology,aquatic biology,bio-acoustics,effects of noise,environmental sound,mammals,hearing,tags
Contextual Text Mining from the Biomedical Scientific Literature (BIOLITCONTEXTMINING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Scientific publications are the main media through which researchers report their new findings. The huge amount and the continuing rapid growth of the number of published articles in biomedicine, has made it particularly difficult for researchers to access and utilize the knowledge contained in them. Currently, there are over 21 million publications indexed in PubMed, which is the main system that provides access to the biomedical literature. Over 2000 new entries are added to the system every day. Developing text mining techniques to automatically extract biologically important information such as relationships between biomolecules is not only useful, but also necessary to facilitate biomedical research and to speed-up scientific progress. Most of the prior studies in the biomedical text mining field tackle the problem of extracting the fact that there is a relationship between a pair of biomolecules. However, for extracted information to make sense, a great deal of biological context is required. While some of this context such as relationship type and directionality is found in the sentence that actually reports the relationship, some of it such as species and experimental method is likely stated elsewhere in the article. The goal of the proposed project is to design methods based on natural language processing and machine learning to extract relationships among biomolecules and their local (sentence-level) and non-local (document-level) context information, as well as to design novel knowledge discovery methods that utilize the extracted contextual information

Keywords: text mining,bioinformatics,information extraction,natural language processing,machine learning,knowledge discovery,protein interaction networks
DEFINING NEW DRUGS AND DRUG TARGETS FOR TREATMENT OF ANEMIA (ERYTHROTHERAPY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

More than a billion people suffer from anemia. The only drug used to symptomatically increase red blood cell production in anemic patients is recombinant erythropoietin (Epo). While Epo injections effectively promote red blood cell production in patients suffering low endogenous Epo production, aplastic anemia and anemia associated with cancer, inflammation and infection do not respond well to recombinant Epo treatment. Aim A: Since there is a great need for new drugs that can treat Epo-resistant anemias the first aim of ERYTHROTHERAPY is to identify novel drug target for production of Epo-responsive cells. Using next-generation mRNA sequencing we identified 250 candidate genes that have the potential to be targeted by drugs and are highly expressed in red blood cell progenitor cells. RNA interference based screening strategies will be used to systematically characterize which if these genes can be targeted to promote red blood cell progenitor proliferation. If successful this study will lead to development of a novel class of erythropoiesis stimulating agents able to manage conditions that today lack pharmacological treatment. Aim B: The second goal of this project is to identify mechanism-based treatment strategies for Diamond-Blackfan anemia (DBA; OMIM #105650). All known DBA disease genes encode for ribosomal protein (RP) genes. Despite the recent advances in DBA genetics the pathophysiology remains elusive, which until now has prevented development of disease-specific therapies. In order to develop effective and specific DBA drugs the ERYTHROTHRAPY proposal uses an animal model for DBA to identify the molecular mechanisms linking RP-deficiency to anemia and bone marrow failure. Since limitations of previous mouse models for DBA make them unsuitable for this research strategy we generated a novel RP-deficient DBA mouse by taking advantage of Doxycycline-regulatable RNA interference. The drug-inducible strategy allows reversible and dose-dependent downregula

Keywords: anemia,bone marrow failure,rna interference screening,drug target discovery,chemical screening,molecular biology,genomics,haematology,molecular genetics,cell biology
The Quaternary Environmental Evolution of the Northwest-Passage (QUEEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2015-02-28
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Despite the significance of the Northwest Passage (NWP) for global oceanic, freshwater, atmospheric, and biological systems, its long-term (last deglaciation onward) marine environmental histories remain understudied. The QUEEN (QUaternary Environmental Evolution of the Northwest-Passage) project seeks to redress this oversight. The project is founded upon an upcoming Geological Survey of Canada-funded expedition through the NWP to the North Atlantic, to collect geological samples along an 8500 km transect. In collaboration with national and international institutions, four interdependent research goals are proposed. Collectively, these would significantly advance our current understanding of the NWP and the adjacent North Atlantic, including: environmental development from deglaciation to present, long-term histories of sea-ice, ice shelves, sea-level, and marine ecosystems. Research themes include the multiproxy study of both long (piston) and short (box) marine core records for biogeochemical characteristics to provide long-term environmental data. Further, to elucidate if recent (post 1850 AD) climatic warming and climatic intervals such as the Medieval Climate Anomaly or Little Ice Age are manifested in Arctic marine records. Additionally, QUEEN seeks to improve the use and fidelity of high-latitude proxies by utilizing new approaches to qualitative and quantitative environmental reconstructions (e.g., marine diatoms, non-pollen palynomorphs, foraminiferal stable isotopes). It further aims to significantly improve radiocarbon-derived NWP chronologies by quantifying potential material-specific error sources, and long marine residence times. Collectively, this research would fundamentally advance our understanding of high-latitude continental shelf environments with major benefits for determining the response of these critical areas to future climate change, thus representing a valuable contribution to Earth System Science.

Keywords: natural sciences,physical sciences,sea ice,environmental change,canadian arctic archipelago,deglaciation,marine,high arctic,palaeoenvironment,high latitude
A Comparative Perspective on Parliamentary Legislative Activity and Bureaucratic Delegation (CPAD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In all parliamentary democracies, governments delegate some policymaking competence to bureaucrats. The very conception of cabinet governments comprised of ministers, who are derived from the party majorities and held in toe with the party line, implies a certain overlap between the executive and legislature. Policy delegation in both presidential and parliamentary systems may be motivated by limited resources, informational asymmetries and a desire to gain from bureaucratic expertise, but it also creates a certain moral hazard by granting bureaucrats the opportunity to act against the legislative preferences of the parliament. Parliamentary legislation can limit the potential for this drift, but also comes at the cost of less informed, more cumbersome legislation and the less efficient use of parliamentary resources. The propensity of decision makers to delegate vary widely across political systems and policy areas. This project asks how differences in the preferences of the legislating actors and the degree of institutional control over bureaucrats may affect the extent of policy delegation in four parliamentary systems (Germany, UK, France and Turkey). Although theoretical approaches to this topic abound, empirical research remains starkly limited. This project will test, extend and refine the transaction cost, principal-agent theory based on divided government in the US presidential system with a comparative perspective on parliamentary democracies. The selected countries vary with regard to their electoral systems, party tradition, level of democratic consolidation and legal tradition. The project will assess the relative potential for and intervening factors limiting or encouraging the use of executive policy instruments in these states over a twenty-five year period. This approach will link bureaucratic delegation to institutional design and political considerations such as popular legitimacy and preference constellations of legislating actors.

Keywords: bureaucratic delegation,comparative legislative behaviour,comparative analysis of parliamentary politics
Cross-Layer Design of Adaptive, Reliable and Energy Efficient Systems (DARE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Switzerland
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Though current day designs carry the promise of meeting the ever escalating demands of high performance/ quality requirements, they often exhibit large power consumption that limits the battery lifetime and generates excessive heat. Besides power consumption, process variations also pose major design concern with scaling of devices that may lead to erroneous computations and loss of stored data threatening the correct operation of future systems. Addressing both issues of low-power and reliable operation simultaneously is one of the most challenging design problems that semiconductor industry is facing today since they are contradictory in nature. The proposed project plans to address both issues by identifying and utilizing algorithmic level characteristics that can allow the design of systems that provide the right trade-offs between output quality, energy consumption and parametric yield under technology imperfections. The feasibility of the proposed cross-layer design methodology is demonstrated by our observation that for DSP systems, all computations are not equally important in shaping the output response. For such systems, some computations are more critical for determining the output quality, while others play a less important role. This information is exploited in this proposal to develop suitable designs for logic and memory elements of wireless systems that are the core of all today’s portable devices. Main target of the proposed project is to reduce the high cost of existing variation-aware techniques and overcome the incompatibility of most of them with DSP systems. Furthermore, in order to improve the energy efficiency of systems the proposal will take into account system level interactions trying to limit the energy wasted in various blocks that may operate unnecessarily in high power/quality modes in case of non-ideal operating conditions. The project is expected to strengthen EU research in one of the most challenging research topics.

Keywords: electrical engineering,computer engineering,energy efficient design,variation-tolerant design,algorthm/architecture co-design,vlsi,wireless systems,voltage over-scaling,reliability
Design, study and development of novel functional hybrid nanomaterials, which consist of a nanoparticle core and an unconventional shell of coordination entities with synergetic properties. (NANOCOORD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2013-02-01
End date: 2017-01-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In many strategic research areas, particularly in electronics and medicine, nanochemistry-based technologies have recently grown considerably owing to the specific properties of the nanoscale (e.g. room temperature superparamagnetism, quantum effects), which are hardly accessible by traditional chemical approaches. In this context, most of the actual research carried out on nanomaterials is looking at functionalizing the surface of nano-objects with selective organic / bioorganic entities to implement and tailor the resulting properties and applied perspectives. In contrast, the consideration of coordination entities, such as transition-metal complexes, on the surface of nano-objects is hitherto rather limited and remains to be investigated in a systematic way. The NANOCOORD project is tackling this purpose with a distinct and unexplored approach of associating coordination entities (CE) to the outer surface of inorganic nanoparticles (NP). Therefore, the proposed strategy is paving the way to specific and remarkable properties such as magnetic bistability or photo-dynamic therapy while enlarging the applications panel. The particular knowledge gap in this research area legitimates the development of the project that visions to exploit the distinctive attributes of nanochemistry and coordination chemistry to design innovative functional materials with complementary properties. In light of the numerous potential applications, it is crucial to stress that this multidisciplinary project does not claim to cover all the possibilities but aims at a more methodical exploration of such NP@CE heterostructures, via a judicious and initially restricted selection of two application fields of high impact: combination therapy and data storage. The potential outcomes are highly relevant from both a fundamental scientific and technological perspective.

Keywords: coordination chemistry,colloidal nanochemistry,transition metal complexes,inorganic nanoparticles,fiunctionalized ligands,physical/biomedical properties,magnetic bistability,functional materials
Self-regulation and cognitive development of infants facing poverty (SRCD-IP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-07-01
End date: 2016-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Children raised in families experiencing poverty face significant adversity early in life that puts them at much greater risk of developing learning difficulties. There is a pressing need to develop early screening and intervention strategies that will be cost-effective and easy to deliver in the community. This proposal brings together research in two fields: cognitive neuroscience and the study of infant-parent interaction, aiming to investigate how the socio-economic status of a family and poor cognitive outcomes later in life are mediated by infant’s emerging self-regulation strategies during interactions with parents in the first 12 months of life and follows up their language and communication outcomes at age 18 months. A better understanding of both social and cognitive basis of developmental difficulties those children face will lead to new early screening and possibly intervention strategies. Interdisciplinary, cutting edge eye-tracking and microanalysis of infant-parent interaction methods will be used to study the subject and to delineate the predictors of emerging problems in infant speech, language and communication development. Application work leading to the development of new screening tools and eye-tracking technology will be undertaken in partnership with academics and industry partners.

Keywords: developmental psychology,cognitive development,infancy,self-regulation,eye-tracking technology,medical instrumentation,socio-economic deprivaton,early screening and intervention
Search for a Dark Matter Signature with the Alpha Magnetic Spectrometer (AMS-02) Experiment (DARKMATTERAMS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Alpha Magnetic Spectrometer is a multi-purpose particle physics experiment that has been carried to the International Space Station with the launch of Space Shuttle Endeavour flight STS-134, that took place on 16th of May, 2011. AMS-02 was installed to its final position on the 19th of May, 2011 and has been taking cosmic-ray data since. AMS has already collected billions of particles in low earth orbit and is now under a calibration and data validation period. AMS will measure cosmic-ray spectrum for photons and charged particles, as well as for primary elements upto Fe with unprecedented accuracy. Specifically, the energy spectra of photons, electrons, positrons and anti-protons can contain signatures of dark-matter annihilation in the galactic halo and METU team will concentrate efforts on understanding these spectra.

Keywords: experimental physics