Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding decision making by linking brain and behaviour (BrainBehaviourModel)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Why do some people make decisions impulsively while others are more cautious? The answer may lie in individual differences in synaptic connectivity strengths within the underlying brain network. Previous work has found correlations between aspects of the decision making process and BOLD or electrophysiological responses. However, a proper mechanistic and biological explanation is still missing. This is nevertheless crucial for understanding how neurotransmitter systems influence behaviour and lead to impulse control disorders, addiction, or eating disorders. To reach this aim, I propose to combine state-of-the-art cognitive models with likewise state-of-the-art models of neural responses. My ‘BrainBehaviour model’ will link cognitive factors that influence behaviour with synaptic connectivity patterns that give rise to neuroimaging findings. Using this model, I will first analyse high-resolution (7T) fMRI data of subjects performing a stop-signal task. I will then turn to a novel data set comprising local field potential recordings obtained from deep brain stimulation electrodes implanted in the subthalamic nucleus for treatment of Parkinson’s disease, in combination with simultaneous MEG. After model inversion, the estimated parameters will be used to test specific hypotheses on the role of the hyperdirect, indirect, and direct pathways in movement inhibition. The project is not only at the forefront of cognitive and computational neuroscience but it also offers invaluable training experiences, including the opportunity to work with high-tech imaging data (7T fMRI), mastering dynamic causal modelling, learning how to apply advanced cognitive models, and a good number of transferable skills like teaching and student supervision. The latter will result in an official teaching certificate that is compulsory for all university lecturers in the Netherlands. Granting this proposal will be a vital step for progressing my career beyond the current postdoctoral level.

Keywords: humans,decision making,movement inhibition,fmri,subthalamic nucleus,mathematical psychology,dynamic causal modelling,bayesian inference,effective connectivity,oscillations
The first predictive test for radio-sensitivity. A step towards an improved and personalised radiation therapy cancer treatment. (NovaTests)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Each year, two out of three cancer patients undergo radiation therapy, meaning close to 1.5M patients in Europe and 2M in the US. However, scientific evidences prove a direct link between radiation therapy and several serious late effects. This because patient’s tolerance to radiation vary significantly and radiotherapy affects indiscriminately both healthy and cancer cells, damaging also active working cells, tissues or organs around the tumour. There is, therefore, an unmet clinical need to tailor treatments to each patient’s unique biology. NovaTests are the first predictive radio-sensitivity tests for cancer treatment. By analysing a simple blood sample, in one week time, we can determine with high accuracy (over 90%) not only whether a patient is sensitive or not to radiation but also how sensitive the patient is. We allow for more efficient treatments and improved quality of cancer survivors, not only during radiation treatments but for the rest of their lives. Our first test, the NovaGray Breast® is aimed at measuring radiosensitivity for breast cancer patients. It meets all regulatory requirements of the 98/79 directive pertaining to the in-vitro diagnostic medical devices, has been stamped with the CE marking in February 2016. So far, €0.5M million have been invested into the development and testing of technology to ensure its robustness and efficiency and move into the next stage of tests development and validation. Within the overall project, we intend to scale-up the process by automating it and run a multi-centre clinical trial to validate the reliability of the test. Further ongoing developments include the extension of the technology to prostate and lung cancers. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of NovaTests and their market uptake.

Keywords: cancer,treatment,tumour,breast,blood,radiation,radiotherapy,sensitivity
Enhancing security of digital property rights and citizens’ awareness through an innovative anti-piracy framework of digital content based on Machine Learning and Artificial Intelligence (3ants)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Spain
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-07-01
End date: 2017-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Digital piracy and counterfeit activity causes incredible economic damages in creative & e-commerce sectors. It jeopardizes the rights of all creative individuals, puts jobs at risks, and undermines new legal business models and distribution platforms. Piracy and counterfeiting the statistic losses sum $125 billion and 2.5 million of jobs. Part of those loss are transformed into benefits to those who break the law and rights. Consumer is not property aware of such impact. 3antS aims to become the main reference cyber-security service framework to fight against contents piracy & digital distribution of counterfeited goods. , 3ANTS mission is to deliver a set of breakthrough cybersecurity SaaS services built over a disruptive self-developed algorithm based on machine learning techniques, that follows as a crawler pirated content & goods through the internet (web, torrents, mobile applications, social networks, e-commerce etc) automatically geo-locating (100% accuracy) the items and forcing their withdrawal (98%) 3antS - over this unique technology –provides a framework of an innovative set of added value SaaS services as a response to the business challenges and opportunities: (1)SaaS to remove specific pirated content & goods (2)Smart Analysis & Reports Scorecard to Support Decision Taken (3)Gamification mobile applications to raise awareness, and engage content public targets against the pirate fighting (4)APIs to allow third parties data entrance or developing of new services over it. 3ants has gone through processes of “design thinking” and “customer discovery & validation” - with more than 31 million of contents removed, having demonstrated the value proposal with reference entities in the media sector as WarnerBros or SonyPictures (TRL7) 3ants aims to scale-up the product internationally, covering all digital content (video, books, music) and main e-commerce segments (fashion, pharma, electronics) achieving an accumulated EBITDA of 44,8M€ by 2023 with 80% margin

Keywords: piracy,counterfeit,property rights,consumers awarness
HAZEL: Commercialization of a novel, high efficiency equipment for the determination of hazardous atmospheric pollutants (HAZEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SEADM is a Spanish SME founded in 2005, whose aim is to become a centre of excellence in the field of analytical instrumentation for the detection of trace elements. Its founder, Yale Professor Juan Fernandez de la Mora, is a world leader in the field of ion mobility. In the last complete review about the integration of ion mobility and mass spectrometry, published by three of the most prestigious academics in the field, SEADM was quoted as owner and developer of 2 of the 6 most relevant ion mobility techniques today: DMA and TM-IMS. SEADM was the only European company appearing in the review. The monitoring and control of atmospheric pollutants is a subject of prime importance worldwide. Recent evidence from the World Health Organization indicates that about one out of eight deaths occurred in the world are actually due to air pollution. The proposed HAZEL project will be devoted to the introduction in the market of a new instrument for the analysis of atmospheric sub-trace pollutants, based upon SEADM technology, with the capability of revolutionizing the field. Among other advantages to be addressed along the present proposal, the HAZEL instrument would generate: 1) a 10-fold slash in the analysis cost vs. state-of-the-art technology, 2) highly automated operation and 3) improved technical performance. The specific objectives of HAZEL Phase 1 are as follows: 1. Technical study to confirm or alternatively redefine the operating parameters of SEADM’s vapour analysis system. Tests will be performed for a selection of representative sub-trace air pollutants. For feasibility assessment, results will be judged against relevant EU standards and regulations. 2. Market study to review the preliminary description of the market presently defined. 3. Study of the present HAZEL Business Plan, in order to validate or alternatively redefine its parameters, including its financing requirements. 4. Study and review of our current strategy on IPR and legal issues.

Keywords: atmospheric analysis,ion mobility,hazardous air pollutants,appi
From Typhoid Fever to Antimicrobial Mechanisms (TYPHI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2020-10-31
Duration (months): 38.0
Total project cost (EUR): 1101358.24
EU funding (EUR): 1101358.24
Participants: 1
Project status: CLOSED

This programme will identify critical host mechanisms that kill bacterial pathogens by exploring a novel mammalian antimicrobial pathway, which I discovered. This pathway protects non-susceptible hosts from typhoid fever. Typhoid fever is caused by Salmonella Typhi, a unique intracellular pathogen that kills more than 200,000 humans per year. Yet, Salmonella Typhi does not infect other mammalian species, such as mice. An understanding of the mechanisms that protect mice from Salmonella Typhi infection will enable me to determine how Salmonella Typhi circumvents these protective mechanisms in humans to cause fatal disease. I have demonstrated that the mechanisms protecting mice are based on an intracellular trafficking process regulated by the Rab32 GTPase. The following critical questions will be addressed: 1) What killing molecules does the Rab32-dependent trafficking pathway deliver to the Salmonella Typhi vacuole? 2) How is the Rab32-dependent trafficking pathway regulated? 3) Is the Rab32-dependent trafficking pathway active in human macrophages? And if so, how does Salmonella Typhi evade killing to replicate in human macrophages? I will define the antimicrobial mechanisms responsible for killing Salmonella Typhi and other bacterial pathogens by exploiting a powerful combination of functional genomics, cutting-edge “omic” approaches and versatile screens. This ambitious, high-gain programme will: I) Identify novel antimicrobial molecules that kill bacterial pathogens; II) Identify critical regulators of this novel antimicrobial pathway; III) Elucidate how Salmonella Typhi establishes deadly infections in humans and identify new therapeutic targets. The overall objective of this programme is to improve global health by capitalising on novel mechanisms of host defence that will not only elucidate ways to treat typhoid, but also extend these insights to the treatment of other bacterial diseases.

Keywords: bacterial infections,bacterial pathogens,salmonella,rab gtpases,typhoid fever,salmonella typhi
Seabirds Under Pressure: Revealing the Effects of Mercury Exposure (SUPREME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Mercury emission into the environment is a globally relevant issue because exposure to mercury represents a significant threat to humans and biodiversity worldwide. Now more than ever, we need to understand how will exposure to mercury contamination affect life history traits of wildlife. SUPREME aims to investigate for the first time the consequences of mercury exposure in seabirds with a particular focus on physiological traits and susceptibility to viral diseases, a topic that clearly deserve further investigations given the dramatic rise in mercury contamination and the likely increase of infectious diseases occurrence in the years to come. The project aims to address two main objectives: i) assess to which extent mercury exposure causes physiological dysfunction and facilitates the manifestation of the disease and ii) determine whether mercury accumulation and viral disease accelerate telomere shortening. The existing high levels of mercury and the annual viral outbreaks that cause the mortality of almost all seabird chicks in the study site (a small island in French Guiana, South America) exploit an unprecedented opportunity to investigate a topic that remains largely unexplored. Not only SUPREME will combine the collection of longitudinal (within-individual variation over time) with experimental data, but will benefit from hundreds of blood samples (i.e. 413) collected by myself from 2015 to 2017. SUPREME has an extra value in terms of conservation because it will be carried out on a colony of Magnificent frigatebirds that is considered one of the most important of South America, acting as a genetic bridge among Brazilian and Caribbean colonies. Never has it been more crucial to liase with competent authorities to implement regulatory measures to limit mercury emission into the environment. SUPREME aims to also reach this objective by demonstrating the impact of environmental contaminants on wildlife health and by transferring the results to local authorities
AN END-TO-END SOLUTION ACCELERATING COST-NEUTRAL RETROFITTING FOR ENERGY-EFFICIENT FAMILY HOMES (FITHOME)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Netherlands
Call: Aggregation - Project Development Assistance (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-05-01
End date: 2024-04-30
Duration (months): 48.0
Total project cost (EUR): 1245430.9
EU funding (EUR): 887812.5
Participants: 3
Project status: SIGNED

FITHOME leads to 900+ retrofitted homes in 3-7 municipalities in the Dutch Alkmaar region. It unlocks €15.75-19.25mn in capital for retrofitting and results in 11.8 ktons of Co2 saved during the project. Energy usage in the participating homes decreases with 64%. FITHOME constitutes three workstreams: 1. rollout of a novel financial instrument; 2. actual retrofittings in “no regret” measures such as PV and isolation via a simplified, customer-centric retrofitting process through digital upfront calculators, process flow management and quality assurance in terms of vendor and material selection and 3. European scale-up and linkage with peer PDA-projects and a Pan-European funding platform. The project: -implements home-based, betterment tax – an instrument allowing homeowners to retrofit homes, while repaying related investments through a municipal a tax over max. 30 years. The investment is property-attached, thus risk-free. The tax height is the difference between the old and new energy bill (resulting from the energy savings thus ensuring neutrality). - is a EU first in applying this scheme at scale. It builds on pilot results in the Municipality of Bergen, while building on insights of the U.S. PACE scheme (220,000 homes retrofitted to date) and the EuroPace project; -focuses on guaranteed no regret retrofitting in PV and isolation, guaranteeing cost neutrality for homeowners; - engages homeowners through tailored, customer engagement campaigns, which are driven by the Municipality of Wijk bij Duurstede (NL); - develops tools that allow crystal clear insight in retrofitting costs and potential, whereas digital integration and process flow management will ensure that the entire retrofitting process (e.g. from application to vendor and material selection) are assured; - allows scaling beyond NL steps are taken to assess feasibility to link in with a Pan-European Investment Platform, while the PDA Working Group ensure ensures continuity and lessons-learned incorporation.

Keywords: on tax financing,betterment tax,no regret retrofitting,cost neural retrofitting
Bump and Hole approach to elucidate function of individual bromodomains of BET proteins (Bump-BET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Small molecules can be used to probe for biological function of individual proteins. Achieving high selectivity with small molecules against structurally similar paralogues is a challenging task that makes it difficult to characterize function of individual member in the same protein family or individual domain in protein containing multiple target domains. The Bromo and Extra-Terminal (BET) proteins play important roles in transcriptional regulation by controlling networks of genes involved in cellular proliferation and cell cycle regulation. Key to the functions of BET proteins is a pair of highly homologous bromodomains (BD) in tandem, which bind and recognize histone acetylation on its tail. Elucidation of the process controlled by BET proteins would benefit greatly from chemical probes that perturb individual BD with high selectivity. Development of small molecules, including clinical candidate drug I-BET, builds a foundation for us to utilize this chemical probe approach, however lack of selectivity of I-BET against individual BD renders it inapplicable to serve as a chemical probe for individual protein or domain. Recently, we had demonstrated the feasibility of a “bump-and-hole” approach to engineer BD of BET proteins and I-BET molecule to achieve high selectivity. Here we propose to enhance the selectivity of BD and I-BET derivative pair to apply this technology and to probe for the function of individual BD in a cell-based model. Interaction between modified I-BET and selected BD variant, which retain its histone binding functionality, will be further optimized to achieve >100 fold selectivity against all wildtype BD. After that, a cell-based model will be built to substitute endogenous BET protein with exogenous BET containing BD variant. The ultimate goal is to develop a general chemical biology tool to elucidate the role of any individual BD-containing proteins by targeting specifically the engineered BD without affecting any other BD.

Keywords: bromodomain,bromo and extra terminal protein,histone modification reader,protein engineering,drug design,bump and hole strategy,protein ligand interaction
in Search Of Certainty - Interactive Event To inspire Young people (SOCIETY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-06-01
End date: 2017-11-30
Duration (months): 18.0
Total project cost (EUR): 155375.0
EU funding (EUR): 155375.0
Participants: 7
Project status: CLOSED

SOCIETY (in Search Of Certainty – Interactive Event To inspire Young People) European Researchers' Night events will take place in 5 cities (Bologna, Forlì, Cesena, Ravenna and Rimini). SOCIETY aims to present research as the best tool to investigate solutions, ideas and innovations to sort out the Societal Challenges that human beings face. In order to achieve its objectives, SOCIETY will rely on interactivity and engagement at large: the project will specifically aim to produce a Night co-design approach, in which researchers together with society will conceive the event programme. SOCIETY project will be extended to two editions of ERN, in 2016 and in 2017, with a project duration of 18 months. The line-up of each Night event will be structured as a subway map, with different lines and stops. Each line will represent an interdisciplinary pathway in some specific big topic for which researchers are trying to find some possible solutions and ideas. The two events will maintain the same overall theme, but a relevant evolution in public collaboration, which will support the design of the programme event, will be envisaged. The co-design of ERN events will act as a concrete lab experience for European researchers in structuring a bottom-up public communication event. The public will have a key role in the project, not only as target, and will be engaged to collaborate in the outline of an event tailored for societal interests. Researchers and research will benefit from this approach as a whole in terms of public support and acknowledgement of the importance of research work for society. SOCIETY Night events will be designed in order to attract different kinds of publics . However, secondary school students, who are about to make their choice in terms of career, will be a privileged target, also through the involvement of Eu and MSCA researchers. Specific activities will be addressed to encourage female young students to embark on scientific and research career.

Keywords: public engagement,event,dissemination,co design,certainty,schools,young people,edutainment,gender balance