Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Redesigning Equality and Scientific Excellence Together (RESET)

Framework: Horizon 2020 — Science with and for Society
Programme: Promote gender equality in particular by supporting structural change in the organisation of research institutions and in the content and design of research activities
Action type: Coordination and support actions
Countries involved: Germany,Finland,Greece,Poland,France,France,Portugal
Call: Supporting research organisations to implement gender equality plans (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 2998297.5
EU funding (EUR): 2998297.5
Participants: 7
Project status: SIGNED

Redesigning Equality and Scientific Excellence Together (RESET) involves seven large multidisciplinary universities from all over Europe, including two “Widening countries”, all distinguished as excellent institutions (labels, clusters, programmes). RESET will address the challenge of Gender Equality in Research Institutions in a diversity perspective, with the objective to design and implement a user-centered, impact-driven and inclusive vision of scientific excellence. Combining an intersectional approach to gender equality with the collective intelligence fostered and harvested through the co-design of the Gender Equality Plans (GEPs), RESET will ensure that proposed changes are met with sustainability and ownership. Mainstreaming the co-design approach as an institutional practice for efficient gender equality policy-making and greater stakeholder engagement and support, will underpin high-quality and high-impact actions. Supervised by Gender Equality Boards, GEPs will be co-designed by all stakeholders during the first year, and revised and upgraded during the fourth year, based on the assessment of their early implementation phase. GEP-related active co-design participation and training actions will operate at the individual, operational and institutional levels for structural change. RESET GEPs will be inspired and enhanced by tailored data analytics to provide insightful knowledge. Full support of top management and implementation of GEPs following the steps defined in EIGE’s GEAR tool will ensure the full integration of RESET activities into local excellence programmes. RESET will transform partner institutions into local living labs, contributing to innovation maximization in close-knit with local and national ecosystems (RPOs, HEIs, municipalities, industry, NGOs and citizens incentives). The RESET experience will strategically use this momentum to promote full replication in other HEIs/RPOs, thus supporting the achievement of ERA’s objective.

Keywords: gender equality plans,organisational change,scientific excellence,diversity,intersectionality,collective intelligence,co design,living lab
Inventing GPS: Technology and International Security in the Cold War and Beyond (Inventing GPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 237768.0
EU funding (EUR): 237768.0
Participants: 2
Project status: SIGNED

One of the most significant technological innovations of the post-war era, the development of GPS revolutionised the way we navigate, fight wars, design maps, and keep time. However, a GPS historiography does not exist yet. The objective of this project is to provide the first in-depth historiographical study of Global Positioning System (GPS) development through new empirical archival evidence and extensive oral history interviews. Relatedly, by exploring the history of satellite-navigation, the project will also contribute to designing policies relevant to the EU’s Common Defence and Security Policy (CDSP). The project will highlight the interconnection of technological innovation in the field of satellite-based navigation with Cold War politics and military-strategic culture. The overarching argument is that the development of GPS was born out of the paradigm transformation that took place within the U.S. Air Force in the early-to-mid 1970s in favour of a ‘counterforce’ military doctrine. The ancillary argument is that GPS was part of a broader attempt by the United States to direct R&D efforts towards regaining qualitative and technological superiority over the Soviet Union in the aftermath of the Strategic Arms Limitation Talks. Additionally, through innovative ‘applied history’ methods, the project will analyse the implications of GALILEO for the future of European security. These issues are particularly timely in the context of increased international tension, the erosion of U.S. leadership in European defence matters, and the related initiatives to further integrate EU defence policies parallel to NATO, particularly after Brexit. Against this background, the project will assess the relevance of independent access to satellite-navigation as an essential tool in any far-sighted policy of EU defence integration. The action will allow the ER to establish himself as a leading scholar in his field and be competitive in the European academic job market.

Keywords: cold war,history of technology,satellite navigation,global positioning system gps,nuclear history and strategy,international security,u s history
Remote Memory Consolidation Based on Activity, Connectivity and Stability; Contribution of Neurons and Astrocytes. (RECENT-TO-REMOTE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 1637500.0
EU funding (EUR): 1637500.0
Participants: 1
Project status: SIGNED

Our remote memories, weeks to decades long, define who we are and how we experience the world, yet almost nothing is known about the neuronal ensembles encoding them, or the mechanisms underlying the transition from recent to remote memory. I propose a novel hypothesis explaining the selection of the ensembles supporting remote memories based on their activity, connectivity and stability. I further suggest that 'systems consolidation', underlying the transition from recent to remote memory, is implemented by ongoing interactions between brain regions. Finally, I propose a novel role for astrocytes in recent and remote memory. My Specific Objectives are to: 1) Provide multi-dimensional characterization of the neuronal ensembles supporting recent and remote memory, by using activity-based tagging to show how recent and remote recall ensembles differ in activity, connectivity and stability. 2) Perturb the functional connectivity underlying 'systems consolidation' by employing connectivity-based tagging to label specific hippocampal and cortical projection neurons, image their activity during recent and remote memory, and causally demonstrate their functional significance to systems consolidation. 3) Determine the role of astrocytes in recent and remote memory consolidation and retrieval. We will manipulate astrocytes to show their role in recent and remote memory, ensemble allocation, and long-distance communication between neuronal populations. We will image astrocytic activity during a memory task to test if they can independently encode memory features, and how their activity corresponds to that of the neurons around them. This pioneering ERC project, comprised of innovative and ambitious experiments going far and beyond the state of the art in the field, will drive considerable progress to our contemporary understanding of the transition from recent to remote memory, identifying ensemble dynamics and critical projections and how they are modulated by astrocytes.

Keywords: remote memory,astrocytes,neuronal ensembles,memory allocation,anterior cingulate cortex acc,hippocampus
Mass Spectrometry-Based Chemoproteomic Profiling of Nav1.7, a Voltage-Gated Sodium Channel (MaSCheNav)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Chronic pain represents a major unmet medical need which has been linked to changes in voltage-gated sodium channels (VGSCs). These channels are transmembrane protein-complexes with a key-role in signal transmission in excitable cells, such as neurons, and allow the flux of Na+ ions through the cellular membrane in response to specific stimuli, thus controlling the generation and propagation of action potentials. Nine VGSC subtypes are known to be expressed in different cell types, and among them subtype Nav1.7 is of extreme interest since it is involved in nociceptive processing (pain-sensing) in the peripheral nervous system. Remarkably, patients suffering from congenital indifference to pain syndrome, which derives from loss-of-function mutations of the gene encoding for Nav1.7, have a dramatically reduced ability to perceive painful stimuli, but are otherwise perfectly healthy. Therefore, Nav1.7 has been recognized as an exciting target for pharmacological treatments of pain. However, detailed structural and functional information is lacking, and its attainment represents a fundamental step in the challenging task of finding Nav subtype-selective modulators. Thus, the main focus of my project is to study ligand-binding events with known modulators, thereby paving the way to the design of safe and selective inhibitors. I will develop, by solid phase peptide synthesis, a chemical probe specifically designed to isolate Nav1.7, using a tandem photoaffinity labeling-bioorthogonal conjugation approach. This probe will be applied in model cell lines expressing the channel, in order to study their binding interaction through mass spectrometry-based chemoproteomics. Once these chemical tools are established and validated in the model system, I will translate them to patient-derived cells, in order to study disease-relevant systems.

Keywords: chemical proteomics,target profiling
Novel therapeutic strategies to treat pancreatic and lung cancer (THERACAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 2499500.0
EU funding (EUR): 2499500.0
Participants: 1
Project status: CLOSED

This proposal is aimed at identifying and functionally validating targets with potential therapeutic value to devise novel strategies to treat two human cancers with unacceptable low survival rates and unmet medical needs: pancreatic ductal adenocarcinoma and K-RAS mutant lung adenocarcinoma. Although these tumor types have distinct pathological and clinical manifestations, they are both driven by K-RAS mutations. Hence, we expect that the proposed studies will generate synergies to accelerate the outcome of the expected results. In the first part of the proposal, we will identify those genes activated in the cancer initiating cells responsible for the onset of pancreatic and lung tumors. We reasoned that genes implicated in the initial stages of tumor development will be maintained during tumor evolution and not be affected by the intra-tumoral heterogeneity generated during tumor progression. We also propose to identify and validate genes capable of reprogramming the desmoplasic stroma characteristic of pancreatic tumors to hamper its pro-tumoral effects. Likewise, we intend to define the molecular events that control senescence, a naturally occurring process that serves as a barrier to tumor development. In the second part of the project, we will interrogate the role of known targets with suspected therapeutic value in tumor progression using a new generation of GEM tumor models that allow the temporal separation of tumor development from target ablation or inactivation. These studies will make it possible to design combination therapies capable of effectively eradicate advanced tumors. The last section of this proposal focuses on the pharmacological validation of these combination therapies using best-in-class inhibitors in state-of-the-art preclinical trial platforms based on GEM and PDX tumor models. The results derived from these studies will guide the design of new clinical trials that should have a positive impact in the treatment of these deadly diseases.

Keywords: pancreatic cancer,lung cancer,mouse models
Establishing a global observational view of the early stages of planet formation and evolution (PROTOPLANETS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1673510.0
EU funding (EUR): 1673510.0
Participants: 1
Project status: SIGNED

Recent observing campaigns have revealed a great diversity in exoplanetary systems whose origin is yet to be understood. How and when planets form, and how they evolve and interact with their birth environment, the protoplanetary disks, are major open questions. Protoplanetary disks evolve and dissipate rapidly while planets are forming, implying a direct feedback between the processes of planet formation and disk evolution. Observing protoplanets still in the early stages of formation and studying their imprints on the disk structure is therefore crucial. PROTOPLANETS aims to establish a global observational picture of the early stages of planetary systems formation and evolution. My team and I will analyze cutting-edge observations on a large sample of protoplanetary disks, calibrated with novel data processing technics and modelled in the light of state-of-the-art simulations, to: (1) search for giant protoplanets still embedded in disks; (2) study the imprints of planet-disk interactions and their dependence on stellar/disk properties; (3) reveal the impact of planets on the disk structure and dust evolution; (4) determine the conditions for terrestrial planet formation in the inner disk regions. The overall ambition of PROTOPLANETS is to understand the diversity of exoplanetary systems by linking the properties of protoplanets with those of the inner and outer disk regions. The project builds on a novel methodology to detect giant protoplanets and at the same time, characterize the birth environment shaped by those planets. As demonstrated by our recent discovery of the first protoplanet imaged in a disk, the direct detection and characterization of protoplanets will be a major breakthrough, enabling probing of processes of planet formation that could only be addressed theoretically before. The properties of such forming planets, constrained by the proposed research, will offer key insights into the timescales, location and processes of planet formation.

Keywords: protoplanetary disks
Untangling the biophysical interactions governing biofilm hydraulic resistance using cyrogel membrane microfluidics (MicroBioMem)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Membrane biofouling is an inevitable factor severely effecting the permeate flux of ultrafiltration systems. This impacts the scalability of cheap, decentralised, low hydrostatic pressure methods such as Gravity driven membrane filtration (GDM). The hydraulic resistance of the biofouling layer is primarily controlled by biofilm, microbial communities embedded within a self-secreted extracellular polymeric matrix (EPS), a structure akin to a colloidal gel. Mesoscale experiments have shown biofilm hydraulic resistance to vary with hydrostatic pressure, however the microscale biophysical interactions inducing this behaviour are unclear. Understanding how hydrostatic pressure shapes EPS composition, spatial distribution and physical development of biofilm structures is crucial to establishing hydrodynamic strategies to reduce biofilm hydraulic resistance. With this proposal I will evaluate how EPS spatiotemporal distribution and local mechanical properties influence microscale fluid transport and the emergence of internal biofilm structures, to impact bulk biofilm hydraulic resistance, under a range of GDM hydrostatic pressures. To achieve this, I will develop a microfluidic platform embedded with a cryogel membrane barrier, enabling detailed monitoring of membrane bound biofilm development and hydraulic resistance under different hydrostatic pressures. Deploying a correlative imaging approach, I will quantify EPS regulation, composition and local mechanics using state of the art optical visualisation techniques paired with microrheological methods from soft matter physics. Evolution of fluid transport will be mapped using particle imaging velocimetry. Relationships between composition and hydraulic resistance established on the microscale will then be tested for scalability on the mesoscale. By directly quantifying biofilm biophysical evolution, this project will offer invaluable insights untangling the microscale interactions governing biofilm hydraulic resistance.

Keywords: membrane biofouling,biofilm formation,microfluidics
Sensor Technology for Food analYsis (Stefy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aim of STEFY project is to facilitate SMEs and large companies in the food safety testing with a new portable tester, this solution does not intend to provide a certification on food quality, generally performed by accredited organizations, but it will be particularly effective and economically convenient to regularly self-check food safety. STEFY food tester main innovation lies on the ability to quickly determine and simultaneously quantify the presence/absence of dozens of molecules for on-site applications. This is due to the newly developed cartridges: glass substrate with advanced anti-reflection coatings combined with functionalized nanoparticles for an optimal signal amplification resulting in a competitive assay. The technology used is based on the Reflective Phantom Interface, an innovative methodology patented by Proxentia, which has been already extensively tested and compared with already existing strategies. The key competitive features of the STEFY tester are several: test duration; simultaneous broad-spectrum monitoring; on-site applicability; versatility; low cost. The outcomes of the STEFY project will: a) facilitate opportune procedures for prevention and/or damage containment; b) reduce risks related to the introduction of potentially dangerous material; c) reduce the use of laboratories to only the most relevant cases; d) reduce the costs while improving quality (lower level of residuals on the product and a reduced environmental impact. With this project the objective is to launch the tester device with customized cartridges in the European market as a fast, reliable and cost-effective way to assess food safety. The current technology readiness level of STEFY project is TRL 7 and it aims at reaching TRL 8-9 by Phase 3. The financing from Phase 1 will provide STEFY with key suggestions on how to customize the device to best fit different application-fields, insights on the tools for marketing and structuring a sales force.

Keywords: food contaminations,food safety testing,rapid test,multiplexing,reflective phantom interface technology,advanced coatings,surface functionalization