Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The kinetic oxygen cycle in chemical sediments (KinO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Temperature is probably the most fundamental parameter is Earth sciences, but vigorously debated for most of Earth’s history. Temperature derived from carbonate 18O/16O isotope ratios (δ18Oc) can be biased by i) kinetic effects, ii) alteration, or iii) late precipitation of secondary carbonates. KinO shows that each of these mechanisms is expected to follow a different trajectory in δ18Oc vs. δ17Oc space. Within this triple oxygen isotope space, different precipitation mechanisms and different types of kinetic effects fall on characteristic slopes, allowing to correct for these effects, which allows attaining absolute paleo-temperatures. Oxygen isotopes are classically analysed in materials presumed to form in near-equilibrium with the water mainly aiming to attain paleo-temperatures. KinO follows a completely different paradigm by specifically focussing on materials with large kinetic isotope effects. This allows quantitative estimates for fundamental parameters other than temperature such as paleo-pH. Sulfate δ18OSO4 is in notorious disequilibrium with water. While sulfite (SO32-) equilibrates with water, the final oxidation step to sulfate (SO42-) induces a kinetic effect. KinO shows how the respective kinetic effects can be identified and corrected for, providing insight into the formation mechanisms, the respective physicochemical conditions (e.g. pH) and formation temperatures. This approach can provide an alteration resistant paleo-thermometer for the Archean. The methodological development proposed in KinO will be employed to understand marine C and O isotope excursions in the geological record including the Paleocene-Eocene-Thermal-Maximum (PETM) and the Neoproterozoic Shurham anomaly. The later represents the largest negative carbon excursion on Earth and precedes the Cambrian explosion of life. The PETM represents the most recent equivalent of a CO2 and CH4 induced climatic excursion associated with the sixth largest mass extinction.

Keywords: oxygen isotopes,kinetic isotope effects,paleo environment,paleo temperature
Cosmic Inflation and Structure Formation Through Global Analysis (Origins)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499984.0
EU funding (EUR): 1499984.0
Participants: 1
Project status: SIGNED

During the last decades, high-precision experiments have made increasingly detailed measurements of diffuse Extragalactic Background Light (EBL) emitted by cosmological sources. This has revolutionized the understanding of our cosmic origins. The Cosmic Microwave Background (CMB) is our most precious resource for understanding the Big Bang, while the Cosmic Infrared and Optical Backgrounds (CIB and COB) provide unique constraints on the evolution of large scale structure from the first galaxies to today. Until recently, measurements of these effects were limited by either foregrounds or instrumental noise. However, the combined signal-to-noise ratio has now grown so large that the interplay between astrophysical confusion and instrumental systematic uncertainties dominate the error budget. To make further process, it has become critical to account for all sources of uncertainties simultaneously. In the Origins project, I will solve this challenge through joint integrated end-to-end analysis of multiple state- of-the-art experiments to construct a single coherent model of all main diffuse astrophysical emission processes from 1 um to 23 GHz. In a novel approach, Origins will utilize archival observations from ACT, AKARI, COBE/DIRBE, COBE/FIRAS, IRAS, Planck, and WMAP, many in the form of raw time- ordered data, with upcoming measurements from Simons Observatory and SPHEREx. This will result in the world’s strongest and most robust constraints on primordial inflationary gravitational waves; the most accurate map of CIB fluctuations published to date; and possibly the world’s first map of large-scale COB fluctuations. Simultaneously, it will redefine our understanding of thermal dust emission in the Milky Way spanning a wide range of the electromagnetic spectrum, and will improve the precision of current models of Zodiacal Light by several orders of magnitude. This Open Science project will define a new paradigm for next-generation CMB B-mode and EBL experiments.
MULti-Tumour based prediction and manipulation of Immune Response (MULTIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: France,Germany,Austria,Greece,Spain,Norway,Switzerland,Canada,Netherlands,Ireland,Croatia,Denmark
Call: Addressing poorly-understood tumour-host interactions to enhance immune system-centred treatment and care interventions in childhood, adolescent, adult and elderly cancer patients. (HORIZON-MISS-2023-CANCER-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 8547711.5
EU funding (EUR): 8547711.5
Participants: 17
Project status: SIGNED

Only few patients respond to tumor treatment as desired. Treatment heavily relies on host tumor interactions, including exploiting the host immune response against the tumor. The underlying mechanisms of host tumor interaction are largely unknown, guidance on specific intervention is missing. To improve outcome, better understanding of tumor-host interaction is needed. Large numbers of molecular snapshots will provide increased phenotyping coverage and better represent tumor-host evolution over time. In an innovative approach, MULTIR aims at investigating not a single tumor entity, but at compiling data from melanoma, lung and bladder cancer (most drugs target specific molecular features, irrespective of the tumor origin) to identify with high power the critical elements in the tumor-host interaction responsible for therapy response. In a multi-disciplinary approach involving leading clinicians, immunologists, experts in omics, digital technologies, social sciences and patient representatives from 10 EU countries and beyond, and an extensive outreach plan to ensure rapid transfer of MULTIR output to society, MULTIR combines existing multi-layer (epidemiological, genetic, clinical, pathologic, imaging, molecular) data from major studies on these tumors, using AI-based approaches to unveil functional modules regulating tumor-host interactions followed by validation of findings in models and synthetic patients. Harmonization with major EU initiatives will maximize use of European resources. Impact on all scientific, technological and societal levels is expected, including increased understanding of tumor-host interactions, generation of a unique resource of harmonized data on three major cancer types available to the community in compliance to the legal and ethics framework, boost of drug discovery, and an AI-based predictor for treatment response. MULTIR outreach plan includes policymakers and regulators, to support prompt assessment and uptake into the health systems. This action is part of the Cancer Mission cluster of projects on “Understanding (tumour-host interactions)”.

Keywords: tumor therapy,personalized treatment,response prediction,immune checkpoint inhibitor,tumor host interaction,artificial intelligence
A methodology for integrating community acceptance of wind energy into energy system modelling (ESM) (SAMVIND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway,Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2026-07-31
Duration (months): 43.0
Total project cost (EUR): 283438.8
EU funding (EUR): 283438.8
Participants: 3
Project status: SIGNED

Decarbonisation of the energy system is key to achieving the Paris Agreement goal of limiting global temperature rise to below 2°C which can be achieved by electrified and interconnected systems with a high share of variable renewables. This transition is shaped by uncertain factors, which include technology innovation, resource availability, and socio-economic variables. Energy system modelling (ESM) has been a key policy tool to study decarbonisation pathways. ESM provides stakeholders in the energy sector with knowledge-based and systematic methods to reach decisions about which technologies to support. However, present day ESM mainly integrates techno-economical input parameters, whereas social factors, such as local responses to new installations, are largely neglected. ESM might therefore produce solutions that are not accepted by communities and as a result, could jeopardize energy transition goals. The main goal of SAMVIND is to develop an innovative and highly interdisciplinary mixed-methods approach to represent community acceptance, stakeholder interests, and well-being variables in ESM. This new methodology will be developed and applied to the case of Norway, a country with excellent wind resources but high local opposition towards their development. The methodology will contribute to elucidate the impacts of community barriers and value the costs and benefits of alternative options on the net zero energy system design in Norway and the effects on long term, whole system decarbonisation in an interconnected Europe. This project will be made possible by combining the applicant’s experience in social acceptance of renewable technologies, and the supervisors and host’s (University of Oslo) expertise in ESM. The methodological and interdisciplinary training-through-research and unique set of skills gained from SAMVIND will position the researcher at the forefront of socio-technical energy transitions modelling.

Keywords: social acceptance of renewable technologies,energy systems modelling,capability approach,well being,stakeholder analysis,norway
Preparing for the ‘Soil Deal for Europe’ Mission (PREPSOIL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Coordination and support actions
Countries involved: Denmark,Netherlands,Sweden,France,Spain,Poland,Belgium,Hungary,Italy,Norway,Germany,Czechia
Call: Preparing the ground for healthy soils: building capacities for engagement, outreach and knowledge (HORIZON-MISS-2021-SOIL-01, 2021)
Start date: 2022-07-01
End date: 2025-06-30
Duration (months): 36.0
Total project cost (EUR): 4990228.5
EU funding (EUR): 4990228.0
Participants: 20
Project status: SIGNED

Lack of knowledge and awareness of the importance of long-term soil health is a major driver of soil degradation affecting its capacity to provide ecosystem services. The ‘Soil Deal for Europe’ Mission proposes a novel approach to R&I for impact, based on Open Science and strong stakeholder and citizen engagement. PREPSOIL will adopt a proactive approach to co-create with stakeholders, leveraging on both offline and online facilities, with the ultimate purpose of generating long-lasting interaction spaces. Furthermore, PREPSOIL will provide the first assessments and efforts towards an improved knowledge base and awareness level on soil health for multiple stakeholders. PREPSOIL’s web portal is envisaged as the European “one-stop-shop” for all information, resources and digital engagement tools for the Mission stakeholders. It will offer an open-source workspace, including collaboration instruments, ready to be expanded to meet requirements from the Mission. This interaction and engagement strategy supports stocktaking and dialogue to understand how regional ‘soil needs’ assessment, supported by harmonised monitoring mechanisms, can lead to action in Living Labs (LLs) and Light Houses (LHs) for soil health. An ambitious 'soil needs' appraisal campaign will be carried out. In combination with other actions, it will provide direction and capacities for the future national soil health monitoring mechanisms, as well as mapping and preparing the implementation of regional LLs through model business plan guidance.

Keywords: randi missions,soil deal,soil health,living lab,lighthouse,knowledge,awareness
Tragic Emotions in the Anthropocene. The Ethical Urgency of Rethinking Ancient and Modern Pity through Citizen Humanities (TragEmA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 2
Project status: SIGNED

What role can emotions felt towards fictional characters, and specifically aroused from ancient drama, possibly play in the 21st century? In an era in which humans’ impact on the earth system leads us to rethink our social, economic, and cultural paradigms, scholars encourage new emotional practices as a contribution to new ways of interrelating with otherness, evoking a transition from the Anthropocene to the Compassionocene. Acknowledging pity as a specific emotional response to Greek tragedy according to Aristotle’s Poetics, TragEmA aims to investigate the relationship between Greek drama, emotional response to contemporary adaptations of ancient plays (i.e., pity and its cognate phenomena such as compassion, empathy, and sympathy) and their ethical impact on the Western world, by considering productions in the UK, France, Italy, and Germany. While scholars have mostly been focused on ancient spectators’ responses and the notion of narrative empathy, this project aims to go beyond the state of the art, applying to a neglected case study – Greek drama today – a new interdisciplinary approach: a comparative-historical approach will be combined with 4Ecognition tools and citizen humanities, opening a dialogue between classical reception, cognitive science, philosophy of emotions, and ethics. Investigating today’s response to Greek drama, TragEmA will explore the mechanisms of in- and exclusion in empathetic practices to define that kind of fellow-feeling that we urgently need to reshape as a contribution to the ethical debate on attention to alterity and diversity. Lastly, it aims to enhance the role of Classics within the European educational curricula as a privileged way to achieve the Sustainable Development Goals. Benefiting from the interdisciplinary environment of Lethica (Strasbourg) and the APGRD (Oxford), and from the expertise of my supervisor E. Zanin, this fellowship will impact my career and boost my knowledge of connecting Classical reception, ethics, and cognitive humanities.

Keywords: ancient greek tragedy,classical reception,tragic emotions,contemporary drama,pity,narrative empathy,cognitive narratology,literary ethics,philosophy of emotions,citizen science
Synapsing Mental Disorders and Neurodegenerative diseases: Towards more effective diagnosis and management of psychiatric symptoms (SYNAPSING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Spain,France,Finland,Germany,United Kingdom,Cyprus,Belgium,Sweden,Italy
Call: Tackling high-burden for patients, under-researched medical conditions (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7531038.94
EU funding (EUR): 6999921.91
Participants: 13
Project status: SIGNED

Disrupted neuronal connectivity and synapse dysfunction can manifest clinically as a range of emotional, behavioural and cognitive symptoms that are common to, and often overlapping in, mental disorders (MDs) such as major depressive disorder, bipolar disorder and schizophrenia and neurodegenerative disorders (NDs) such as Alzheimer’s disease and Parkinson’s disease. Antidepressants and antipsychotics used to treat these symptoms are often ineffective in ND patients and treatment-resistance is common in MD patients. To tackle the burden exacted on society by untreated psychiatric symptoms, Synapsing will generate the first trans-European clinical collection of clinical, neuroimaging and socioeconomic data from >3000 patients from MD and ND clinics for use in Synapsing and beyond. Synapsing aims to introduce a biological framework for MDs through a search for blood biomarkers to engender a faster, more objective diagnosis and reduce misdiagnosis with NDs. To minimise the use of inefficient treatments across MDs and NDs, Synapsing will develop blood biomarkers to objectively monitor therapeutic response and to stratify patients who would benefit from therapeutic intervention. To guide the development of more effective treatments, Synapsing will model synapse dysfunction using post-mortem brain tissue and induced pluripotent stem cell derived neurons from MD and ND patients. To prevent social disparities impacting on healthcare, Synapsing will identify modifiable socioeconomic risk factors for psychiatric symptoms in >2000 individuals with a lived experience of mental health issues and MD and ND patients recruited across Europe. Recommendations for evidence-based policy initiatives targeted towards reducing these risk factors will be disseminated to EU council agencies. Expected outcomes include better understanding of these under-researched conditions, revised clinical guidelines to better diagnose and manage patients and strengthened knowledge and care networks.

Keywords: major depressive disorder,bipolar disorder,schizophrenia,alzheimer s disease,parkinson s disease,biomarkers,synapse,induced pluripotent stem cells,neurology,psychiatry,social sciences
Connecting advisOrs towaRd a European NETwork for consumer-producer chains (COREnet)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Italy,Ireland,Belgium,Poland,France,Hungary,Romania,Portugal,Sweden,Netherlands,Austria
Call: Developing EU advisory networks on consumer-producer chains (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-09-15
End date: 2027-09-14
Duration (months): 60.0
Total project cost (EUR): 3998662.5
EU funding (EUR): 3998662.5
Participants: 16
Project status: SIGNED

Short Food Supply Chains (SFSCs) or producer-consumer chains are supply chains involving a limited number of intermediaries between farmers and consumers, who are committed to cooperation, local economic development, and maintaining close geographical and social relations. In rebuilding post-Covid, SFSCs are being promoted by governments, civil society and consumer groups in many EU member states as a means for building more inclusive, resilient and sustainable food systems. But SFSC initiators, participants and promoters are confronted by a fragmented knowledge landscape, coupled with a lack of clarity as to essential skills and competencies in all phases from farm to fork. The COREnet project proposes to respond by supporting the systematic development of more effective SFSC advising, based on bringing together public, private and civic advisors through IT-enabled peer-to-peer learning and mutual support. This approach requires interacting with advisors, farmers, consumers and a more holistic approach aimed at helping SFSCs achieve not just a bigger market share, but a greener market impact. Project activities are concerned with (1) developing SFSC advisory capabilities based on a knowledge mapping and on-line listing of SFSC advisors from all EU27 in ways that enable the sharing and exchange of cost-effective practice solutions that improve SFSC social, economic and environmental performance and increase their impact in the food value chain; (2) preparing learning resources in the form of a network of 30 Golden Cases (exemplars of SFSC models that have achieved business success) and initiating 27 Lighthouse Projects (initiatives using Golden cases to introduce advisory services for improving SFSC performance with at least one in each of the EU-27); (3) establishing a pan-European peer-to-peer learning network for SFSC advisors and proposing a formal organizational solution that assures its sustainability and integration into the AKIS.

Keywords: short food supply chains sfscs,sustainable food systems,farmers and primary producers,consumers,innovation support services,akis,agricultural advisors,rural development,social innovation