Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Once Only Principle Project (TOOP)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Innovation actions
Countries involved: Austria,Germany,Italy,Austria,Germany,Germany,Estonia,Germany,Belgium,Switzerland,Greece,Greece,Sweden,Türkiye,Slovakia,Norway,Norway,Bulgaria,Finland,Greece,Lithuania,Romania,Slovenia,Sweden,Greece,Poland,Latvia,France,Netherlands,Netherlands,Netherlands,Portugal,Denmark,Luxembourg,Denmark,Denmark
Call: Co-creation between public administrations: once-only principle (H2020-SC6-CO-CREATION-2016-2, 2016)
Start date: 2017-01-01
End date: 2021-03-31
Duration (months): 51.0
Total project cost (EUR): 8195093.57
EU funding (EUR): 7996708.17
Participants: 72
Project status: SIGNED

The “Once-Only” Principle Project (TOOP) explores and demonstrates the “once-only” principle through multiple sustainable pilots, using a federated architecture on a cross-border collaborative pan-European scale in order to identify drivers and barriers and to provide a basis for future implementations and wider use. Three pilots are implemented: (1) Cross-border e-Services for Business Mobility, (2) Updating Connected Company Data and (3) Online Ship and Crew Certificates. TOOP has the ambition to connect 59 information systems from 21 countries. The methodological approach of TOOP is based on an exploratory and agile pilot life-cycle approach to cross-border pilots, the planning and implementation of which is supported by the development of a generic federated architecture and building blocks, the identification and mitigation of barriers, including legal issues, and the evaluation of the results, with pro-active dissemination and sustainable exploitation of the results throughout the project. TOOP’s main technological innovation is a generic federated OOP architecture that supports the interconnection and interoperability of national registries at the EU level. The pilots planned are ambitious as they contain innovations and provide a basis for recommendations for future implementations and the wider use of the OOP. The project is an important learning environment for OOP in particular and European e-Government in general. The pilots are scalable and can be extended to all Member States in subsequent years. TOOP’s consortium of 51 organisations consists of 19 national administrations (or authorized thereby) from 19 different EU Member States and 2 Associated Countries. The public administrations provide effective piloting, research partners make sure that the key preconditions for effective piloting are met, and private entities support exploitation, all complementing each other in the whole range of activities and areas dealt with in TOOP.

Keywords: once only principle,co creation between public administrations,public sector innovation,agile development,federated architecture
CLEARING HOUSE - Collaborative Learning in Research, Information-sharing and Governance on How Urban tree-based solutions support Sino-European urban futures (CLEARING HOUSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Germany,Spain,Hong Kong,Belgium,Poland,China,Belgium,Poland,Switzerland,Finland,Croatia,Poland,Belgium,Finland,France
Call: Strengthening international cooperation on sustainable urbanisation: nature-based solutions for restoration and rehabilitation of urban ecosystems (H2020-SC5-2018-2, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 7687863.75
EU funding (EUR): 4986463.75
Participants: 26
Project status: SIGNED

Trees and forests are a proven nature-based solution that contribute to sustainable urban development. Their potential for delivering ecosystem services, enhancing biodiversity and contributing to the wellbeing of urban societies is often underestimated and underused. CLEARING HOUSE provides evidence and tools that facilitate mobilising the full potential of urban forests as nature-based solutions (UF-NBS) for rehabilitating, reconnecting and restoring urban ecosystems. UF-NBS comprise every measure a city can take to address urban development challenges by deploying tree-based ecosystems. CLEARING HOUSE will review existing knowledge and will collect new data from large scale analyses (WP1), and evidence emerging from the comparative analysis of ten case studies in Europe and China (WP2), including a citizen science approach. Knowledge will relate to the social, economic and policy drivers of UF-NBS, their design and implementation, and their impacts on urban ecosystem and human wellbeing across continents. CLEARING HOUSE implements a co-design approach early in the project to ensure that its research programme exactly fits the demand of end-users, and engages stakeholders and scientists in problem-oriented knowledge generation through a set of targeted learning mechanisms (WP3). CLEARING HOUSE then develops user-targeted outputs to support cities, planners, business and civil society in implementing UF-NBS. Inter alia, decision support tools such as an online application, a global benchmarking tool and guidelines will provide knowledge on the design, governance and management of UF-NBS, and on sustainable business models relating to them (WP4). Target group specific communication and dissemination activities complement the project. These include Sino-European science-policy symposia (WP5) targeting senior decision-makers, activities targeting businesses and civil society organisations, and measures reaching out to citizens including school children (WP5).

Keywords: sustainable urbanisation,nature based solutions,urban trees,urban forest,green infrastructure,ecological connectivity,ecosystem services,socio ecological resilience,adaptive capacity
Skilled Intentionality for 'Higher' Embodied Cognition: Joining forces with a field of affordances in flux (AFFORDS-HIGHER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1499850.0
EU funding (EUR): 1499850.0
Participants: 1
Project status: CLOSED

In many situations experts act adequately, yet without deliberation. Architects e.g, immediately sense opportunities offered by the site of a new project. One could label these manifestations of expert intuition as ‘higher-level’ cognition, but still these experts act unreflectively. The aim of my project is to develop the Skilled Intentionality Framework (SIF), a new conceptual framework for the field of embodied/enactive cognitive science (Chemero, 2009; Thompson, 2007). I argue that affordances - possibilities for action provided by our surroundings - are highly significant in cases of unreflective and reflective ‘higher’ cognition. Skilled Intentionality is skilled coordination with multiple affordances simultaneously. The two central ideas behind this proposal are (a) that episodes of skilled ‘higher’ cognition can be understood as responsiveness to affordances for ‘higher’ cognition and (b) that our surroundings are highly resourceful and contribute to skillful action and cognition in a far more fundamental way than is generally acknowledged. I use embedded philosophical research in a particular practice of architecture to shed new light on the ways in which affordances for ‘higher’ cognition support creative imagination, anticipation, explicit planning and self-reflection. The Skilled Intentionality Framework is groundbreaking in relating findings established at several complementary levels of analysis: philosophy/phenomenology, ecological psychology, affective science and neurodynamics. Empirical findings thought to be exclusively valid for everyday unreflective action can now be used to explain skilled ‘higher’ cognition as well. Moreover, SIF brings both the context and the social back into cognitive science. I will show SIF’s relevance for Friston’s work on the anticipating brain, and apply it in the domain of architecture and public health. SIF will radically widen the scope of the increasingly influential field of embodied cognitive science.

Keywords: affordances,radical embodied cognitive science,enaction,actionism,philosophy of ecological psychology,phenomenology,merleau ponty,wittgenstein,gibson,friston,action readiness,skilled action
A digestion and absorption mimicking bench-top intestinal model (DINAMIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-04-01
End date: 2021-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Oral administration of drugs is the method of choice for patients and healthcare providers alike because it is both convenient and inexpensive. About 70-90% of the drug candidates have low solubility in the water-based environment of the gut, and therefore a number of strategies have been developed to increase drug solubility, one of these being Lipid-Based Formulations (LBFs). Currently, less than 4% of commercial drug products are LBFs due, in large part, to the difficulty of characterisation of in vivo performance, resulting in slower and more costly drug development and fewer oral drug formulations on the market. Clearly, there is a pressing need for a rapid, inexpensive, accurate, and integrated method to screen and evaluate the performance of LBFs in a physiologically relevant environment. We have developed a novel in vitro assay that can rapidly and accurately evaluate in vivo drug exposure. Dr. Bergström was previously awarded an ERC Starting Grant in 2014 to investigate the dynamics of drug, dosage form, and the complex environment of the gastrointestinal tract; DINAMIC is a direct result of this work. Whereas the current state-of-the-art methods involve analysis of LBF digestion and permeation in separate assays, DINAMIC is an integrated digestion-permeation setup that provides a more physiologically relevant, and thereby more accurate, description of LBF performance and drug bioavailability in less than an hour. The technical and commercial feasibility of DINAMIC will be assessed in this ERC PoC project, including development of a prototype that meets the needs of the target customers, as well as the commercial proof-of-concept.

Keywords: digestion,permeation,absorption,drug formulation assessment,biopharmaceutical profiling,in vitro in vivo
Circadian Regulation Of Brown Adipose Thermogenesis (aCROBAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-10-31
Duration (months): 66.0
Total project cost (EUR): 1497007.51
EU funding (EUR): 1497007.51
Participants: 1
Project status: CLOSED

Obesity and diabetes have reached pandemic proportions and new therapeutic strategies are critically needed. Brown adipose tissue (BAT), a major source of heat production, possesses significant energy-dissipating capacity and therefore represents a promising target to use in combating these diseases. Recently, I discovered a novel link between circadian rhythm and thermogenic stress in the control of the conserved, calorie-burning functions of BAT. Circadian and thermogenic signaling to BAT incorporates blood-borne hormonal and nutrient cues with direct neuronal input. Yet how these responses coordinately shape BAT energy-expending potential through the regulation of cell surface receptors, metabolic enzymes, and transcriptional effectors is still not understood. My primary goal is to investigate this previously unappreciated network of crosstalk that allows mammals to effectively orchestrate daily rhythms in BAT metabolism, while maintaining their ability to adapt to abrupt changes in energy demand. My group will address this question using gain and loss-of-function in vitro and in vivo studies, newly-generated mouse models, customized physiological phenotyping, and cutting-edge advances in next generation RNA sequencing and mass spectrometry. Preliminary, small-scale validations of our methodologies have already yielded a number of novel candidates that may drive key facets of BAT metabolism. Additionally, we will extend our circadian and thermogenic studies into humans to evaluate the translational potential. Our results will advance the fundamental understanding of how daily oscillations in bioenergetic networks establish a framework for the anticipation of and adaptation to environmental challenges. Importantly, we expect that these mechanistic insights will reveal pharmacological targets through which we can unlock evolutionary constraints and harness the energy-expending potential of BAT for the prevention and treatment of obesity and diabetes.

Keywords: circadian rhythm,brown adipose tissue,energy expenditure,diabetes,obesity
Innovative Micro Solar Heat and Power System for Domestic and Small Business Residential Buildings (Innova MicroSolar)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Italy,France,United Kingdom,United Kingdom
Call: New heating and cooling solutions using low grade sources of thermal energy (H2020-EE-2016-RIA-IA, 2016)
Start date: 2016-09-01
End date: 2022-04-30
Duration (months): 68.0
Total project cost (EUR): 3999383.75
EU funding (EUR): 3999383.75
Participants: 9
Project status: CLOSED

Rapid expansion of utilisation of solar thermal energy for increasing energy efficiency of buildings have been adopted in short/medium- and long-term Energy Strategies of EU countries in line with regional actions with the European climate energy objectives as defined in the European Union’s “20-20-20” targets and in the European Commission’s Energy Roadmap 2050. The overall objective of this project is to develop an innovative high performance and cost effective 2-kWel/18-kWth solar heat and power system for application in individual dwellings and small business residential buildings for on-site electricity and heat generation using solar thermal energy at temperature levels of 250-280 deg.C. The proposed technology will be laboratory validated and undergo filed tests on a demonstration site. The project will utilise the expertise of the consortium members in the development of small Organic Rankine Cycle plants, linear Fresnel mirror solar energy concentrating collectors; advanced heat pipe technologies for the thermal management; high performance Thermal Energy Storage systems on the basis of Phase Change Materials; smart control units for integration of solar thermal and boiler heating circuits. Also participants of this Project are experienced in integration of Renewable energy technologies into buildings, optimisation of complex plants and in analysis and predictions of socio-economic impact and in commercialisation of new Renewable energy products; It is estimated that the proposed technology will deliver 60% of domestic energy requirements and provide 20% reduction in energy costs and Green House Gas (GHG) emissions compared to the best existing low carbon energy technologies. In this way the project will also assist in improving the quality of life of population within and outside the EU and provide clean, efficient and secure energy to dwellings.

Keywords: space heating,domestic hot water supply,on site electricity generation,upgrade of solar thermal energy
PROJECTED MEMRISTOR: A nanoscale device for cognitive computing (PROJESTOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2021-06-30
Duration (months): 60.0
Total project cost (EUR): 2555525.0
EU funding (EUR): 2555525.0
Participants: 1
Project status: CLOSED

We are entering the third era of computing: cognitive computing, which holds great promise in terms of deriving intelligence/knowledge from huge volumes of data. Today’s cognitive computers are based on the von Neumann architecture, in which the computing and the memory units are separated. Cognitive computing, however, is inherently data-centric, meaning that huge amounts of data need to be shuttled back and forth at high speeds, a task at which that architecture is highly inefficient. It is becoming increasingly clear that to build efficient cognitive computers, we need to transition to non-von Neumann architectures where memory and logic coexist in some form. Brain-inspired neuromorphic computing and the fascinating new area of memcomputing are two key non-von Neumann approaches being researched. The critical element in these novel computing paradigms is a very-high-density, low power, variable-state, programmable and non-volatile nanoscale memory device. A technological breakthrough that will lead us to this device will be a game-changer for cognitive computing. The goal of this project is to explore one such device concept that I co-invented at IBM Research - Zurich and which we have dubbed “projected memristor” or “projestor” for short. The projestor is indeed a memristor, i.e., a resistive element that remembers the history of the current that previously flowed through the device. The distinguishing feature of a projestor is that the physical mechanism of resistance storage is decoupled from the information retrieval process. In the first part of the project, we will design and fabricate projestor devices to establish the concept of projection and assess its merits and drawbacks. In the second part, we will expand the concept substantially to explore highly innovative projestor devices. In the third part, we will explore various applications of projestors in neuromorphic computing and memcomputing, with a particular focus on real-time data analytics.

Keywords: memristors,nanoscale devices,phase change materials,neuromorphic engineering,memcomputing,cognitive computing,artificial intelligence,statistical inference,machine learning
Bioenergetics in Arid Environments (BARREN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Arid environments are habitats of energetic stringency because of extreme air temperatures and periods of decreased food and water abundance. Typically, birds confronted with these conditions reduce their energetic metabolism to be in balance with local resources. The ability to adjust energetic metabolism to face the harshness of arid habitats has been a significant question in ornithology and ecological physiology for decades. Recent evidence indicates the important role of the mitochondrial oxidative phosphorylation pathway – OxPhos – in this process. However, an effort to combine microevolutionary and physiology concepts remains to be attempted. The current advances in avian genomics combined with my background in ornithology, ecology and evolution provide the best opportunity to study adaptation to arid environments. In BARREN, I propose to integrate ecological properties of an arid environment with variation at OxPhos-related genes, and energy metabolism at cellular and organismal level in a sophisticated systems approach that, to the best of my knowledge, has never been attempted. Through placement at Copenhagen’s Centre for GeoGenetics, I will have access to one of Europe’s leading research groups in avian genomics. A short secondment at the University of Angers will confer additional training in avian physiology. BARREN offers an exceptional opportunity for me to expand on my previous knowledge through implementing a multidimensional and cutting-edge approach centred on genome-level data, in order to advance our understanding of bioenergetics in arid habitats. This project is not only pivotal for basic evolutionary research, but is relevant for one of the key issues of Horizon2020: prepare excellent scientists to address one of the major societal concerns: Fighting and adapting to climate change.

Keywords: evolution,genomics,physiology,geospatial analysis,oxidative phosporilation pathway