Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Future Occupant Safety for Crashes in Cars (OSCCAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Germany,Sweden,China,Belgium,Belgium,France,France,Netherlands
Call: Protection of all road users in crashes (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-06-01
End date: 2021-11-30
Duration (months): 42.0
Total project cost (EUR): 7688334.5
EU funding (EUR): 6989395.0
Participants: 28
Project status: CLOSED

OOSCCAR uses a comprehensive integrated approach for the development of future advanced occupant protection systems. It will provide a unique human body model (HBM)-based development and assessment framework, covering main challenges of future road safety due to the introduction of highly automated vehicles as well as changes in demographics: relevant accident scenarios (mixed traffic), future vehicle interior designs, new occupant sitting positions, ageing population etc. This demands for targeted changes and adaptions of scenarios, procedures and tools for occupant safety development, assessment and homologation, not addressed by e.g. regulations or consumer crash tests today. The resulting complexity requires an emphasis on virtual methods. Based on the analysis of future relevant accident scenarios and considering new, highly automated vehicles (HAVs) enabled sitting positions, OSCCAR will develop and demonstrate advanced occupant protection principles. These require assessment with improved HBMs (omni-directionally biofidelic, active and robust), considering gender and demographic factors as well as improved soft tissues material properties. Furthermore, OSCCAR will develop fully integrated assessment methods for complex test scenarios of the complete crash phase providing the required level of confidence as current physical test procedures do. OSCCAR will also contribute to the harmonization of HBMs, a harmonized validation of injury criteria as well as the improvement of virtual testing standards. Eventually OSCCAR will develop a clear roadmap towards large scale implementation of virtual testing methods for advanced safety solutions, not only relevant in the automotive domain but also for two-wheelers, VRUs, or in sports. Due to its excellent partner consortium with key players from industry and research from Europe, North America and Asia, OSCCAR is in the position to ensure global future deployment and application of its results and achievements.

Keywords: advanced occupant protection principles,automated driving,future accident scenarios,omnidirectional active human body models,anthropometry,injury criteria,virtual assessment,harmonization
Four experiments in Topological Superconductivity. (4-TOPS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 2497567.0
EU funding (EUR): 2497567.0
Participants: 1
Project status: CLOSED

Topological materials have developed rapidly in recent years, with my previous ERC-AG project 3-TOP playing a major role in this development. While so far no bulk topological superconductor has been unambiguously demonstrated, their properties can be studied in a very flexible manner by inducing superconductivity through the proximity effect into the surface or edge states of a topological insulator. In 4-TOPS we will explore the possibilities of this approach in full, and conduct a thorough study of induced superconductivity in both two and three dimensional HgTe based topological insulators. The 4 avenues we will follow are: -SQUID based devices to investigate full phase dependent spectroscopy of the gapless Andreev bound state by studying their Josephson radiation and current-phase relationships. -Experiments aimed at providing unambiguous proof of localized Majorana states in TI junctions by studying tunnelling transport into such states. -Attempts to induce superconductivity in Quantum Hall states with the aim of creating a chiral topological superconductor. These chiral superconductors host Majorana fermions at their edges, which, at least in the case of a single QH edge mode, follow non-Abelian statistics and are therefore promising for explorations in topological quantum computing. -Studies of induced superconductivity in Weyl semimetals, a completely unexplored state of matter. Taken together, these four sets of experiments will greatly enhance our understanding of topological superconductivity, which is not only a subject of great academic interest as it constitutes the study of new phases of matter, but also has potential application in the field of quantum information processing.

Keywords: topological insulators
METAbolism of bone METAstasis (META2): Metabolic interactions between disseminated breast cancer cells and osteoblast lineage cells drive bone metastases formation (META2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Triple negative breast cancer cells (TNBC) metastasize to the bone, resulting in progressive bone destruction and severe complications for the patient. TNBC colonize the bone already much earlier, but they often stay dormant for several years and remain undetectable. Recent studies showed that at this early stage, TNBC cells are in close proximity to bone-forming cells (osteoblasts), and this interaction promotes TNBC survival and proliferation. Interestingly, recent findings also indicate that the metabolism of tumor cells not only drives primary tumor growth, but also determines which cells will metastasize to lung or liver, indicating metabolic interactions of TNBC with their microenvironment. This concept may also apply to TNBC in bone, but insight in the metabolism of TNBC colonizing the bone is lacking. I hypothesize that to survive and thrive in the bone TNBC cells rely on a specific profile that is complementary in nutrient needs to osteoblasts. Accordingly, preliminary results of the lab showed that targeting glutamine pathway impaired bone metastasis formation. Thus, my objective is to characterize the metabolism of TNBC in bone at early time points and to validate that targeting this metabolism will limit or prevent bone metastasis. I will first perform metabolite dosage and transcriptomics on TNBC recovered at early stages of preclinical (mouse) models of bone metastasis. In parallel, I will decipher metabolic interactions in vitro between osteoblasts and TNBC using metabolomics. These two complimentary approaches will deliver fundamental insights into metabolic adaptations of TNBC during bone metastasis, and identification of the most interesting enzymes to target. I will then validate these targets through functional studies in preclinical models and analysis of expression levels in patient tumor samples. This better understanding of the metabolism of TNBC in the bone is essential for the development of new diagnostic tools and therapeutic targets.

Keywords: bone,metastasis,metabolism,breast cancer
Cultural transmission and technological evolution in southernmost Africa c. 44 – 12 kcal. BP (CulTech)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

CulTech proposes a probabilistic and spatially explicit simulation-based study to test the roles of population fragmentation and coalescence to explain variability in the southern African late Pleistocene lithic record. It focuses on the interval c. 44 – 12 kcal. BP relevant to onset and maturation of the Later Stone Age (LSA). The project asks three key questions: Q1) To what extent is the degree to which southern African late Pleistocene LSA lithic assemblages differ as a function of space and time? Q2) Are these patterns of similarity/dissimilarity consistent with expectations derived from simulated population coalescence and fragmentation scenarios? Q3) How do these patterns change through time across the period c. 44 – 12 kcal. BP? It draws on a multi-variate dataset including radiocarbon dates and lithic technological data to develop a series of simulation and model-based approaches to examine the possible demographic dimensions of late Pleistocene technological variability in southern Africa. CulTech builds on a growing field of computational modelling and simulation-based approaches applied to studies of prehistoric cultural transmission. Simulation based approaches are efficient and can accommodate several variations in population size, density, structure, rates of interaction and mechanisms of cultural transmission. The project draws its principle datasets from southern Africa’s long history of LSA lithic research to evaluate the degree of fit between patterns in the region’s site spatial distribution, lithic data, and expectations from a series of simulations to generate expected population coalescence/fragmentation patterns and their effects on the lithic data. The outcomes of these models will contribute significantly to discussions about cultural transmission and population processes in hunter-gatherer societies. These topics are of relevance not just to southern Africa, but to human evolution and global archaeology in general.

Keywords: lithic technology,population demography,cultural transmission,msa lsa transition,computer modelling
Magnetoelectrics Beyond 2020: A Training Programme on Energy-Efficient Magnetoelectric Nanomaterials for Advanced Information and Healthcare Technologies (BeMAGIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Germany,Spain,Italy,Italy,Austria,Austria,Switzerland,Finland,France,Czechia,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 3954491.64
EU funding (EUR): 3954491.64
Participants: 15
Project status: SIGNED

BeMAGIC is a highly interdisciplinary venture whose primary aim is the training of young researchers in the utilization of magnetoelectric (ME) nanomaterials to face important societal challenges linked to energy-efficiency, data security and health. The Network encompasses the design, synthesis, characterization and integration of ME materials into a variety of applications that share in common the combined action of electric and magnetic fields: advanced security systems, low-power data storage, spintronic/magnonic devices, electric-field assisted anti-cancer drug delivery, cell electrofusion and deep neural stimulation. Studying all these technological domains in parallel will accelerate progress in each individual field because there are a number of cross-cutting synergistic challenges and potential cross-fertilization outcomes. Various disciplines (Physics, Chemistry, Engineering, Bioelectronics, Biomedicine) converge together in BeMAGIC to provide a holistic approach to fulfil the proposed goals. Special efforts will be devoted to bridge basic science with system prototyping and market exploitation, covering several of the Key Enabling Technologies of the Horizon 2020 Programme. The Consortium brings together 13 Beneficiaries and 11 Partner Organizations, including 8 private companies, from 11 EU Member States. The partnership is diverse and gender-balanced (6 Beneficiary Scientists-in-Charge are female). The complementarities among partners will render a high-level, multifaceted educational programme in which world-class research will be combined with unique training opportunities in soft skills (career planning, dissemination, entrepreneurship, intellectual property rights, management, etc.). A continuous peer-mentoring of all activities will be performed in a pro-active manner to ensure that BeMAGIC generates highly-qualified specialists able to face future professional challenges, either in Academia or Industry, in a proficient manner.

Keywords: magnetoelectricity,nanomaterials,multiferroics,magneto ionics,energy efficiency,data security,wireless cell stimulation
Dynamics of Artificial MagPhonic Spin Ice (DYNAMPSI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Poland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 137625.6
EU funding (EUR): 137625.6
Participants: 1
Project status: CLOSED

In general, ordered arrays of nanomagnets with strong magnetostatic interactions forms magnonic crystals where spin waves, which are the fundamental magnetic excitation in a metallic ferromagnetic material with frequencies in the microwave regime. Similar to magnonic crystal, phononic crystals are also special periodic materials with great promise for controlling and manipulating the propagation of elastic waves. Interestingly, the elastic waves and spin waves of comparable wavelength can propagate simultaneously in magnonic structures in the same gigahertz frequency range. This opens the perspective for extending the functionalities of wave-processing nanodevices by combining the properties of spin waves and elastic waves. Recently, artificial spin ice has emerged as a new candidate for reconfigurable magnonic devices, where the specific geometries and resulting magnetic configurations give a variety of interesting magnonic properties. But the influence of magnetoelastic coupling on the spin wave dispersion of magnonic crystals and especially artificial spin ice systems is still unexplored field. In this project, we are aiming to tune the magnetic band structure for an artificial magphonic spin ice (AMPSI) system, which increases the applications of spin ices, as a reconfigurable magnonic crystals. This follows to the main objectives of this project, which is to demonstrate programmable Fan-Out magnonic device using AMPSI and to study the magnetic monopole dynamics in AMPSI.

Keywords: magnonics,phononics,spinwaves,artificial spin ice,magnetization dynamics,spintronics
SuperScienceMe: REsearch is your R-Evolution - European Researchers' Night (SuperScienceMe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy,Italy,Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-07-01
End date: 2021-04-30
Duration (months): 10.0
Total project cost (EUR): 533968.37
EU funding (EUR): 298677.0
Participants: 6
Project status: CLOSED

SuperScienceMe - REsearch is your R-Evolution aims at reaching the general public of Calabria and Basilicata regions in Southern Italy, focusing in particular on the young ones. SuperScienceMe proposes a fascinating journey across several epochs of human evolution and science, to convey the message that research represents an intrinsic character of mankind, being, for this reason, free of any barrier and stereotype. Research is human richness and, just like human fantasy and imagination,can’t be confined nor limited. Research is freedom. In this historical epoch, the sensibility of people must be brought back to the values of equality and inclusion, strongly promoted and pursued by the European Union. Within this scenario, especially young people must be taken care of and educated in order to appreciate the beauty of diversity. Research can play this game successfully. Based on these considerations and on the successful previous editions of the NIGHT, SuperScienceMe expands its boundaries, including in the partnership another region of Southern Italy, to promote inclusiveness and equality through Research. The activities of the NIGHT will be developed in research centres as well as in locations which are uncommon for science,like hospitals and juvenile prisons, to explain how research revolutions have driven the fantastic evolution of mankind. To open their wings towards the general public, researchers will tell the compelling story of research speaking the language of non-experts in science, challenging each other to show that they are nothing but ordinary people, just like everyone else, doing an extraordinary job, which consists in looking at nature and trying to appreciate and understand its elusive secrets. European Union was conceived on the pillars of a society based on innovation, research, equality and inclusiveness. SuperScienceMe has been thought to reinvigorate these concepts showing the exciting journey of research through the eras of human evolution.

Keywords: science journey,enjoing research,social inclusion,innovation promotion,dissemination of scientific culture,scientainment
Coordination chemistry in doubly stabilized micelles for the tageted delivery of cytostatic drugs in cancer therapy (Lx Micelles)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The treatment of cancer with chemotherapeutic drugs is very often associated with severe side effects limiting their tolerated dose and leading to insufficient therapeutic effects. The application of such drugs in nanometer-sized micelles may improve their biodistribution, but in vivo studies showed fast drug release in the blood stream. We aim for prolonged drug retention and intracellular release by introducing the stable, yet reversible Lx linker in the core of bioresorbable polymeric micelles. This coordinative platinum linker will have two functions: (1) it will facilitate the stable conjugation between the drug molecule and the polymer molecules constituting the micelle and (2) it will act as a stabilizer between the polymer molecules constituting the micelle. This will result in excellent stability of the drug-loaded micelles in circulation. Due to the enhanced permeability and retention effect the micelles will accumulate in tumor tissue, where they will be destabilized intracellularly and the drugs will be released from the linker in the cytoplasm after competitive glutathione displacement. The Lx linker presents various advantages over other crosslink methods, such as versatility and ease of crosslinking. No platinum-related toxicity was observed in vivo for the linker in previous research. In addition, the amount of platinum may be considered negligible since powerful drugs will be loaded onto the micelles. This approach represents a safe and unique hybrid method which has the potential to significantly increase the amount of drug deposited at the target tissue and to reduce side effects at non-target sites. By pursuing this significant step forward in cancer therapy, the fellowship will broaden the Experienced Researcher’s scientific and non-scientific skills via advanced training as well as transnational and transdisciplinary mobility. Furthermore, it will facilitate a lively transfer of knowledge between the participants due to their complementarity.

Keywords: nanomedicine,cancer,micelle,controlled drug delivery,biomedical polymer,polymer drug conjugate,biomedical application
Precisely Oriented Porous Crystalline Films and Patterns (POPCRYSTAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-07-31
Duration (months): 75.0
Total project cost (EUR): 1996315.0
EU funding (EUR): 1996315.0
Participants: 1
Project status: SIGNED

Metal-Organic Frameworks (MOFs) are nanoporous crystalline solids with narrow pore distributions and high accessible surface areas. MOFs are typically prepared in a polycrystalline form via the self-assembly of inorganic (nodes) and organic (links) building units. This bottom-up approach allows for properties such as, pore size, topology and chemical functionality to be precisely tailored. Such synthetic control has identified MOFs as promising platform material for device fabrication in the areas of microelectronics, photonics, sensing. However, current methods for fabricating MOF films and patterns cannot generate precisely oriented crystals on commercially relevant scales (i.e. cm). Thus, limiting access to applications that require anisotropic functional properties (e.g. optics, electronics, separation). POPCRYSTAL will enable the fabrication of films and patterns composed of precisely oriented MOF crystals by exploiting crystalline ceramics to guide the aligned growth of MOF crystals. Remarkably, the scale of these heteroepitaxially grown MOFs is solely determined by the ceramic precursor which can be easily synthesized on areas covering mm2 to cm2. POPCRYSTAL will advance a proof of concept study by addressing the following important research aims: the basic understanding of the formation mechanism and rules governing the heteroepitaxial relationship (WP1), the extension to different ceramic-MOF systems (WP2), the control over crystalline porous film and pattern features (WP3) and the fabrication of a proof-of-concept that will highlight the importance of aligned pores for separation (WP4). In summary, by exploiting the heteroepitaxial growth mechanism between ceramics and MOFs POPOCRYSTAL will fabricate unprecedented crystalline MOF films and patterns with precisely oriented nanopores and nanochannels. Thus POPCRYSTAL intercrosses and connects nanoscale chemistry, controlled self-assembly on a macroscale and nanoporous-based device fabrication.

Keywords: metal organic frameworks,mofs,crystal growth