Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ELEVVO: A Ground-breaking Wearable Brain-Computer Interface that Enables Self-management of Cognitive Welfare through Personalised Training Exercises (ELEVVO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cognitive decline (progressive loss of mental cognitive abilities) is a natural event that affects us all after the age of 40. Although age is a main factor, low-demanding brain activity can speed up the process & end up in cognitive impairment, which is a major cause of disability worldwide. Importantly, the onset & progress of cognitive decline can be hindered with preventive training that stimulates cognitive abilities. This realization is driving the market of cognitive training, foreseeing a $7.5 billion turnover and 83% population adoption by 2020. This growth will be mostly driven by the revolution of wearables & biometric technologies, which are increasing rapidly as people become more prone to manage their own health. However, current market offerings for brain training either need the presence of a clinical specialist or lack any scientific relevance. In response, we at BitBrain Technologies have developed ELEVVO, a ground-breaking neuro-wearable technology that enables self-management of cognitive welfare and yields real measurable enhancement. ELEVVO uses a gaming approach to train cognitive-related patterns, relying on intelligent big-data mining to automatically tailor the challenges to the users’ brain rhythms and to measure the progress achieved. Importantly, ELEVVO will be the only scientifically-validated product for cognitive training in the mass market. Indeed, we have proved the ELEVVO’s efficiency in healthy adults (students, workers, elderly) and in neuropathology cases. Altogether, with this project we aim to finalise the development of ELEVVO and to scale-up our deployment capability. The Feasibility Study planned in Phase 1 will help us warrant the project from all technical, commercial & financial standpoints. Upon completion, ELEVVO will bring a major social & economic impact to society, enhancing life-quality & well-being. In turn, it will boost the growth of our company, projecting a R..

Keywords: brain computer interface,neuroscientific intelligence,cognitive enhancement,ground breaking neuro ict,self management of cognitive welfare,effective brain training,preventing cognitive impairmen
Efficient Structures and Processes for Reliable Perovskite Solar Modules (ESPResSo)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Spain,Cyprus,Switzerland,Poland,Sweden,Belgium,France,United Kingdom,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2017-RES-RIA-TwoStage, 2017)
Start date: 2018-04-01
End date: 2021-09-30
Duration (months): 42.0
Total project cost (EUR): 5412657.5
EU funding (EUR): 5412657.5
Participants: 13
Project status: CLOSED

This ESPResSo-project aims to bring the novel emerging hybrid organic-inorganic perovskite-based solar cell (PSC) technology to its next maturity level. In recent years (see Figure 1), this solution-processable solar technology has reached cell efficiency values rivalling those of established thin-film photovoltaic (PV) technology (CIGS, CdTe), even approaching crystalline Si (c-Si) records. The challenge is now to transfer this unprecedented progress from its cell level into a scalable, stable, low-cost technology on module level. The consortium brought together here has alternative materials, insights in novel cell concepts and architectures, and the processing know-how and equipment at hand to overcome these barriers and realize following global objective: Demonstrate a highly efficient (>17%) perovskite-based 35x35cm² module architecture that shows long-term (>20 years) reliable performance as deduced from IEC-compliant test conditions. This module is to be produced with industry-relevant low CAPEX manufacturing techniques validating a potential electricity cost as low as 0.05€/kWh in Southern Europe. Installing an actual building-integrated facade element will validate the potential contribution of this technology to the future European energy supply system. Additionally, prototyping advanced, arbitrary-shaped module architectures with specific materials and process combinations will emphasize that new highly innovative applications like on flexible substrates or with high semi-transparency are well accessible on mid- to longer-term with this very promising thin-film PV technology.

Keywords: photovoltaics,perovskite,modules
Chemical Tools for Unravelling Sirtuin Function (SIRFUNCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2022-03-31
Duration (months): 60.0
Total project cost (EUR): 1758742.0
EU funding (EUR): 1758742.0
Participants: 1
Project status: CLOSED

It was recently realized that lysine acetylation affects a wide variety of cellular processes in addition to the initially recognized histone related gene regulation. Together with recent groundbreaking results, revealing the presence of additional acyllysine modifications, the basis for a paradigm shift in this area was formed. Examples of enzymes formerly thought to be lysine deacetylases, have been shown to cleave these new types of lysine modification and members of the sirtuin class of enzymes play a central role. Development of new tools to investigate the importance of these new modifications as well as the sirtuins that cleave them is required. We therefore propose to adopt an interdisciplinary approach by developing selective inhibitors and so-called activity-based probes (ABPs) and applying these to the investigation of proteins recognizing novel post-translational acylations of lysine residues in cells. Such ABPs will be powerful tools for providing insight regarding this rapidly evolving area of biochemistry; however, the current state-of-the-art in ABP design is endowed with severe limitations because the modifications are inherently cleaved by various hydrolases in human cells. Thus, in the present project, I propose that novel designs accommodating non-cleavable modifications are warranted to maintain structural integrity during experiments. Furthermore, I propose to apply similar mechanism-based designs to develop potent and isoform-selective sirtuin inhibitors, which will serve as chemical probes to investigate links between cancer and metabolism, and may ultimately serve as lead compounds for pre-clinical pharmaceutical development. AIM-I. (a) Development and (b) application of collections of chemical probes for activity-based investigation of enzymes that interact with post-translationally acylated proteins. AIM-II. Utilization of structural and mechanistic insight to design potent and selective inhibitors of sirtuin enzymes.

Keywords: enzymology,enzyme inhibitors,activity based probes,sirtuins,post translational modifications,peptides
Circadian Control of Histone Methylation Dynamics through the Fine-tuning of Methionine Metabolic Flux (MetEpiClock)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2022-10-01
Duration (months): 36.0
Total project cost (EUR): 262269.0
EU funding (EUR): 262269.0
Participants: 2
Project status: CLOSED

The circadian clock directs almost all aspects of diurnal physiology, including metabolism. Defects in circadian rhythms influence physiology and behavior with implications for numerous pathological conditions, including cancer, metabolic syndrome, obesity, diabetes and cardiovascular diseases. By controlling metabolic homeostasis at the cellular level, the clock can directly influence cellular regulatory networks, including those that govern chromatin dynamics. The goal of this proposal is to investigate if metabolic pathways able to influence gene expression via chromatin dynamics are under circadian control and whether these regulatory networks are crucial for the maintenance of a correct metabolic homeostasis. We will test if the clock governs the “methylation potential” of the cell by regulating the diurnal expression of rate-limiting enzymes of methionine metabolism. By using metabolite restriction, pharmacological and gene editing approaches we will disrupt circadian rhythmicity of SAM and SAH. We will then use state-of-the-art methods including, transcriptomics, epigenomics and metabolomics to investigate the impact of this regulatory network on circadian transcriptional regulation, histone methylation dynamics and metabolic homeostasis. By dissecting how circadian regulation, metabolism and epigenetics are interconnected we will gain novel insights into how these factors contribute to normal physiology and disease. At UCI I will exploit the expertise of the outgoing supervisor in the area of circadian biology, molecular metabolism and epigenetics. Then, at Humanitas University I will refine the knowledge and skills acquired during the outgoing phase, with the final aim of applying them to the cardiovascular field. This will place me in a privileged position to establish myself as a competent researcher within the European Community, in the field of cardiovascular biology, metabolism and epigenetics.

Keywords: metabolism,methionine cycle,epigenetics,histone methylation,circadian rhythms
Large Deviations in Random Matrix Theory (LDRaM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-09-01
End date: 2026-08-31
Duration (months): 72.0
Total project cost (EUR): 2384537.5
EU funding (EUR): 2384537.5
Participants: 1
Project status: SIGNED

Large deviations theory develops the art of estimating the probability of rare events. The classical theory concentrates on the study of the probability of deviating from the behavior predicted by the law of large numbers, namely the probability that the empirical mean of independent variables differs from its expectation. Such a classical framework does not apply in random matrix theory where one deals with complicated functions of independent variables or strongly interacting random variables, for instance the eigenvalues of a matrix with independent entries. During the last twenty years, important advances allowed to analyze large deviations for a few specific models of random matrices, but a full understanding of these questions is still missing. The object of this project is to develop such a theory. Two notable examples motivate this project. The first is to understand how the distribution of the entries of a random matrix affects the probability of the rare events of its spectrum as its dimension goes to infinity. The second is to prove in great generality the convergence of matrix integrals and Voiculescu's microstates entropy, as well as analyze their limit. The impact of this project would go beyond probability and operator algebra as it would apply to other fields such as theoretical physics, statistics and statistical learning.
RESILIENT2: A novel thermosensory module at the interface of temperature and defense signaling (RESILIENCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The proposed project aims to define the molecular framework at the interface of plant immunity and temperature signaling pathways. To sense and respond to external environmental cues is critical for adaptation of plants to local environments. Temperature is a key seasonal variable controlling plant processes like developmental decisions as well as outcomes of plant-pathogen interactions. Elevated temperatures cause reduced resistance to pathogens resulting in enhanced susceptibility. Climate change, most importantly increasing global temperatures, poses a severe threat to agriculture and biodiversity. Though known for long, the phenomenon of temperature induced disease susceptibility is not sufficiently well understood at the molecular level. A unique Arabidopsis mutant resilient2 (res2) with temperature resilient defense response has been identified through a novel forward genetic screen. The res2 mutant also displays defective temperature sensing phenotypes suggesting that RES2 encodes a novel thermosensory molecule that modulate plant defense. I will systematically characterize the res2 mutant to define the molecular mechanism by which RES2 regulates temperature sensing and plant immunity. Findings of this study will answer the longstanding fundamental biology question of how environmental signals are integrated, especially the molecular basis for temperature induced defense breakdown. This will contribute to developing climate resilient crops in the wake of unprecedented increase in temperature as a result of global climate change.

Keywords: plant pathogen interaction,temperature,resilient,defense,arabidopsis
Microbial Degradation of Jellyfish-Derived Substrates (MIDAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-02
End date: 2020-07-01
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

The complex pool of dissolved organic matter (DOM) in the oceans is almost exclusively accessible to diverse members of microbial community carrying out different types of metabolism thereby, affecting biogeochemical state of the ocean. To predict the response of the marine ecosystem to natural and anthropogenic perturbations, a mechanistic understanding on the relation between the organic matter (OM) field and the metabolic network operated by the microbial community needs to be refined. One largely overlooked, but significant source of DOM are jellyfish. Regardless the debate over the accuracy of their reported global increase and on the true cause of the observed jellyfish fluctuations, the increase in their population size can have serious ecological and socio-economic consequences. As jellyfish blooms decay, sinking carcasses represent large quantities of detrital OM (jelly-OM), rich in proteins and hence, a high quality substrate for the ambient bacterial community. However, the exact processes and mechanisms of bacterial jelly-OM degradation remain unknown. In the MIDAS project, an integrated interdisciplinary approach will be applied to characterize the composition of jelly-OM at the molecular level and the metabolic network operated by jelly-OM degrading bacterial communities using state-of-the-art analytical tools (ultra-high resolution mass spectrometry) and cutting edge –omics techniques combining emerging fields of marine metaproteomics and exoproteomics. This knowledge will enable us understanding the implications of jellyfish blooms on biogeochemical cycles in coastal seas.

Keywords: jellyfish blooms,dissolved organic matter,marine microbial community,biodegradation,metaproteomics,exoproteomics,ultra high resolution mass spectrometry,biogeochemical cycles
Reappraising Western European Repertoires for Puppet and Marionette Theatres (PuppetPlays)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2288832.0
EU funding (EUR): 2288832.0
Participants: 1
Project status: SIGNED

This project aims at transcending boundaries between « high » and « popular » cultures, here established playwrights and anonymous writers, by investigating their productions for a same medium: puppet and marionette theatre. Focusing on key-periods of drama history (1600-2000) it explores how puppeteers and authors both contribute to the raise of a specific dramaturgy. Introducing these repertoires into the history of Western European drama opens a double ground-breaking perspective: on one side, it exceeds the limits of local inquiries and reveals cultural transfers through social groups and nations; on the other, it leads to reexamine theatre historiography by considering the cohesion of “theatrical systems” (Marotti) and giving visibility to a long despised and scatered corpus. The main objectives are 1) to gather a corpus of representative plays which document the development of puppetry in Western Europe (Austria, Belgium, England, France, Germany, Italy, Nederlands, Portugal, Spain); 2) to identify the specific features of puppet and marionette plays and their variations through time, cultural areas, conditions of production and targeted audiences; 3) to re-evaluate the contribution of these repertoires to the construction of European cultural identity. The principal investigator brings to this project, besides a long experience of internationally recognized research, an excellent knowledge of artistic and cultural networks which guarantees the access to primary sources as well as the mobilisation of experts and partner institutions. Using digital humanities tools and methods, the project will produce a platform making available the selected corpus through a data base and searchable thesaurus, and offering innovative resources to the research community, pedagogues, practitioners and public at large. The research will lead to a better integration of puppetry into theatre history, an increased knowledge of its heritage, and a growing institutional recognition.

Keywords: puppetry,history of drama,cultural transfers
Detection and Speciation of Gas-Phase Atmospheric Peroxy and Criegee Radicals (EPHEMERAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Norway,Sweden,France,France,France
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 3419744.0
EU funding (EUR): 2670244.0
Participants: 5
Project status: SIGNED

Earth’s lower atmosphere is oxidative and its chemistry consists of reactions of short-lived chemical compounds called radicals, controlling the abundance of key compounds, such as of ozone and greenhouse gases. In spite of decades of investigation many atmospheric observations indicate that important aspects of this radical chemistry remain ill-understood, in particular in the reactions of the multitude of organic radicals present in the atmosphere, peroxy radicals (“RO2”) and Criegee Intermediates (“CI”). Detailed investigations of these reactions have been limited for over 50 years by instrumental challenges, in particular by the lack of technique detecting individual radicals (”speciation”). Recently, the Nozière group achieved an important milestone by developing the first technique, based on Chemical Ionization Mass Spectrometry or “CIMS”, speciating the volatile RO2 that are important for the atmospheric oxidation cycles. The objective of EPHEMERAL is to solve key questions in atmospheric radical chemistry by overcoming the long-standing instrumental challenges with cutting-edge developments based on this new technique. Three strategic directions will be pursued: - in laboratory, the detection of CI will be investigated and gas-phase reactions of RO2 and CI studied, - an instrument will be built to detect individual RO2 and CI in the atmosphere, thus achieving a historical milestone, - the reactivity of these radicals at/with surfaces will be investigated in laboratory, assessing for the first time the role of clouds and aerosols in the oxidation cycles and setting the bases for next-generation challenges. The fundamental knowledge and atmospheric observations resulting from this project will dramatically improve the understanding of the oxidation cycles and the predictions of the atmospheric chemical composition, from the regional to the climate scale. EPHEMERAL will thus place Europe at the leading edge in the discipline, scientifically and technologically.