Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New biocide dry toilet with improved hygienic functionalities (DRYCLOSET)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: France,Germany,Finland,Spain,Spain,Spain
Call:  (FP7-SME-2010-1, 2010)
Start date: 2010-12-01
End date: 2012-11-30
Duration (months): 24.0
Total project cost (EUR): 1291884.83
EU funding (EUR): 1020907.0
Participants: 6
Project status: CLOSED

Water is essential for life. This element supposes also a determinant factor in the economy and ecology of the different regions. But water not only has influence in the human life, humans also affect to water cycle. The human activity is responsible of the climate change by which the Mediterranean region is being affected by drought and water shortage. Water shortage in Mediterranea countries is becoming an essential question. The domestic sector accounted for about 24 percent of total water withdrawn in Europe in 2000, which is about 7,320,00ML. In fact, toilet flushing supposes 30% of the domestic use of urban water. The consume of such amount of water could be avoided using dry toilets, it is calculated saving of 50L/cap/day. In addition, it is estimated more than 20 million citizens without access to a safe sanitation in Europe. This situation is critical in rural areas of eastern European, where the most common system in these areas usually consist of pit latrines and septic tanks. Dry toilets are common in Nordic countries but their rustic technology makes them unacceptable in urban or large communities. At present dry toilets implies several factors, such as unpleasant odours and the manual manipulation of the latrine waste, which makes them unviable in most of urban environments. Also, there are other problems of drytoilets such as struvite formation on pipe connections. But this situation can be changed by applying the technical innovations that will be developed in this project. In adittion, the project’s success will allow the possibility to save important drinking water (1,875L/cap/year). This will be of essential importance in the Mediterranean countries, where the drought menace is each time more obvious. The use of dry toilets in rural areas with poor infrastructure will have safe sanitation systems to citizens DRYCLOSET project will develop a new dry toilet with a biocide toilet, low bad odours emissions and low maintenance.

Keywords: biofilter,coating,struvite precipitate,wastewater
Carbon nanotube structures as innovative electrode materials for more efficient energy storage devices (NANOTUBE ENERGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Efficient capture, storage, and controlled release of energy are major global challenges for the twenty-first century. Dramatic improvement in the performance of energy storage &amp; conversion devices is needed to meet future energy demands of our society, mainly in electrical propulsion (full electric vehicle) and to overcome the inevitable future shortage in fossil fuels, especially in gasoline. By combining Professor Aurbach (Bar Ilan University) expertise of electrochemistry, especially of Li and Mg, with Dr. Gilbert Nessim (MIT) capabilities in synthesizing dense arrays of crystalline carbon nanotubes (CNTs) on metallic layers, we propose to investigate the development of more efficient batteries that use composite metal-CNTs as electrodes. The main novelty of our approach is to use functionalized carbon structures on various nanotube electrode materials to improve ion insertion and storage, safety, and performance of Li ion based batteries in ionic liquid and in electrolyte solution with wide electrochemical window. The technical plan includes the investigation of multiple electrode materials and geometries upon which CNTs will be grown and functionalized to optimize electrode performance and cycling. Additional aspects of this project include applying the techniques and materials developed to lead acid batteries and to design more efficient supercapacitors. Extensive collaboration with MIT and with other academic and industrial institutions in Europe and the USA is a key aspect of this multi-disciplinary project. The goal of the project is to reintegrate Dr. Nessim at Bar Ilan as a faculty in the department of chemistry.

Keywords: lithium,carbon nanotubes,energy storage,electrochemistry
MECHANISMS OF HEPATITIS C VIRUS ENTRY IN POLARIZED CELLS (HCV-POLAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Hepatitis C poses a global health problem. Hepatitis C virus (HCV) infects over 170 millions individuals worldwide with the majority remaining undiagnosed and untreated. To this day, there is no vaccine and the available treatment, a combination of ribavirin and pegylated α-interferon has a limited efficacy and important side effects. A better understanding of HCV life cycle will unravel target for new potential therapeutics. In recent years, the knowledge concerning hepatitis C virus (HCV) entry inside the cells has improved, suggesting a complex mechanism involving several (co)receptors. All the studies regarding HCV entry have been performed in non polarized cells, however HCV infects primarily hepatocytes that are highly polarized cells with a complex organization. Polarized cells have two separate membrane domain, the apical and basolateral domain, with different functions and molecular composition. Separation of the two domain is achieved by complex and tightly regulated intracellular trafficking. Tight junction proteins, which play an essential role in cell polarization, figure in the different molecules involved in HCV entry. This suggests that cell polarity might be relevant to HCV entry and probably add supplementary constraints on HCV entry. In this project I therefore propose to study the mechanisms of HCV entry in polarized cells. To develop this project, a model of polarized hepatic cells will be established and used to investigate the specific roles of entry factors, the intracellular trafficking of the virus, the role of cytoskeleton in HCV entry and the dependence on signaling to mediate entry. The data generated in this project will shed new light on a complex and tightly regulated process. Importantly, studying entry in polarized hepatocytes should also bridge the gap between in vitro data and HCV infection in patients. This is especially important as HCV so far lacks a suitable animal model.

Keywords: virology,virus entry,hepatitis c virus,cellular virology,polarized cells
Receptor-like Kinase Signalling in Arabidopsis thaliana Root Development (REKSARD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Belgium
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2011-06-25
End date: 2014-06-24
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 2
Project status: CLOSED

The past decade researchers have mainly focused on the analyses of phytohormone gradients and mobile transcription factors to explain patterning. In Arabidopsis, model processes like primary and lateral root development are well understood on the level of transcriptional changes and hormonal control, but very little attention has been given to an alternative way of cell-cell communication using ligand-receptor-like kinase systems (De Smet et al., 2009, Nat Cell Biol, in press). Lately a number of receptor-like kinases and potential ligands have been described in root development (De Smet et al., 2008, Science 322:494-497; Müller et al., 2008, Plant Cell 20:934-946; Stahl et al., 2009, Curr Biol 19:909-14), making it a perfect time to start investigating how these receptor-like kinases and their respective ligands control the different developmental processes and what their targets are. More and more tools become available to study difficult membrane proteins on the level of 3D structure, phosphoproteomics, and in silico ligand identification. In brief, I will use different and interdisciplinary strategies, based on state of the art transcriptomics, proteomics, interactomics, associomics and more in depth analysis on the single gene/protein/ligand level to describe ligand-receptor-mediated cell-cell communication during root development, and, more specifically, to identify key components in ACR4-dependent signalling. The aspects this project plans to address would contribute extensively to the knowledge of membrane associated receptors-like kinases in general, have rarely been covered focusing on one receptor-like kinase, and will allow elucidating the mechanisms and structural aspects behind this crucial ACF4-dependent signaling pathway, such as: (1) identification of downstream genome-wide transcriptional changes, (2) identification of substrates on a proteome-wide scale, and (3) identification and physical interaction of ligands with the receptor domain.
The academic voice in quality and internationalisation of Czech and British higher education (ACVOIHE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-05-10
End date: 2013-05-09
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The proposed research concerns the issue of internationalisation in higher education and its relation to higher education quality. Quality in higher education has gained attention particularly over the last two decades (Westerheijden et al, 1994). Internationalisation in higher education is a phenomenon which has also recently become a widespread and strategically significant topic in higher education (Van der Wende and Westerheijden, 2001), and has developed in parallel with quality in higher education. In particular, the research proposes to investigate internationalisation and its relation to higher education quality through the academic voice in the Czech and British higher education systems. These issues are currently high on the agenda of many European higher education systems, including the Czech and British systems. The research study will utilise a “critical event” narrative inquiry method, which is a novel qualitative method ideally suited to investigate complex issues, such as internationalisation and quality in higher education. The essence of the “critical event” narrative inquiry method is in the identification of “critical events” in professional practice of individuals, in the case of this proposed research it will be the British and Czech academics and higher education leaders. To the researcher’s knowledge, higher education quality and internationalisation have not yet been investigated utilising such a method, nor have they both been previously investigated from an academic perspective. Thus, it is proposed that such research would be of great value to European higher education and potentially to other higher education systems worldwide, particularly in terms of further policy development.

Keywords: higher education quality,internationalisation,academic voice,critical event narrative inquiry,czech higher education,british higher education
A role for the immunomodulatory capsular polysaccharide Sp1 expressed by Streptococcus pneumoniae in the treatment of Asthma (SP1 AND ASTHMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-10-01
End date: 2014-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposal will enable the candidate to successfully transition from a high profile US university to one of Europe’s leading universities, Trinity College Dublin (TCD), ranked 13th in Europe by the Times Higher Educational Supplement 2008. The candidate is poised to make major contributions to the Irish and EU research community by establishing her career at TCD. The candidate’s stellar research achievements and credibility as a scientist are evidenced by the fact that she has been awarded a prestigious career development award (CDA) from the Wellcome Trust, which will facilitate the move to Dublin. A Marie Curie IRG would significantly enhance the candidate’s career development within the EU over and above that achievable under the terms of the CDA. Specifically funding through this IRG alone would allow the candidate to a) grow and establish a research group at TCD by recruiting and training students b) continue a program of work in TCD that has already begun in Boston and can only be continued through funding from the IRG c) secure a long lasting collaboration with a high an internationally renowned scientist at Harvard Medical school, enhancing ties between this world famous institute and TCD d) diversify their research program by pursuing a project entirely distinct from that funded by the CDA. The proposed project represents an entirely novel approach for treatment of asthma by harnessing the immunomodulatory effects of a capsular polysaccharide molecule expressed by the airway commensal organism Streptococcus pneumoniae. It is predicted that Sp1 will induce immunomodulatory cytokines to protect against airway inflammation.

Keywords: immunomodulatory therapy,asthma,zwitterionic capsular polysaccharides,regulatory cytokines
Genetic Analysis of Vascular Development in Zebrafish (VASCDEVZEB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The development of the vascular system is one of the earliest events in organogenesis. All other organs depend on a vascular supply for delivery of nutrients, oxygen and cellular and humoral factors, and for clearance of wastes. Serious disruptions in the formation of the vascular network are lethal early in post-implantation, while the maintenance of vessel integrity and the control of vessel physiology have important consequences throughout embryonic and adult life. Research carried out over the past years has shed light into the different steps involved in the formation of the vascular system. Genetic evidence has highlighted the roles of many molecules that affect vasculogenesis, angiogenesis and lymphangiogenesis in a complex and tightly regulated manner. Many of the signaling pathways implicated in vascular development are reactivated during disease states of angiogenesis or vessel regression, making a full understanding of the complexities of these pathways important for identifying new targets for therapeutic intervention during pathological situations such as severe tissue ischemia, coronary heart disease, lymphedema and tumor promoted angiogenesis and lymphangiogenesis. The objective of this proposal is to use the accessible zebrafish embryo, which has a well-described, stereotypical vertebrate vasculature, to identify and characterize novel players involved in the formation of blood and lymphatic vessels. The strength of our approach lies in our ability to combine unique in vivo assays, powerful genetic tools, and sophisticated long term imaging of living embryos. As most developmental processes are remarkably similar between zebrafish and humans, both in molecular aspects and function, these studies are likely to reveal conserved pathways regulating the development and function of blood and lymphatic endothelial cells in humans.

Keywords: developmental biology,genetics angiogenesis,lymphangiogenesis,zebrafish,vascular,endothelial
Celiac Disease HLA typing using microfabricated genoSENSarray (CD-HLASENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2013-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Coeliac disease (CD) is a gluten-sensitive enteropathy that affects as much as 1% of the population. Patients with CD should maintain a lifelong gluten-free diet, in order to avoid serious complications. It is essential to diagnose CD at the earliest possible conjecture. The Human Leukocyte Antigen system (HLA) is the human major histocompatibility complex. HLA typing is fundamental in hystocompatibility and previous to solid organ and bone marrow transplantation. In CD, HLA typing can find application in establishing the genetic risk and the association between certain HLA types. The overall objective of CD-HLAsens is therefore to develop a generic technological platform for CD point-of-care diagnostics capable of genomic detection with electrochemical transduction. Genosensors microarrays for the screening of CD disease will be developed based on the detection of nucleic acids associated with genetic predisposition, i.e. HLA typing. Such detection strategy could be used for general population screening but also for neonatal screening. Together with classical assay formats, novel biomolecule detection schemes based on supramolecular associations will be developed with the aim to fine tune the specificity and sensitivity of the sensors. The Researcher will design, new surface chemistry for the functionalisation and operation of the genosensors arrays based on the experiences gained during his previous MC fellowship and new research avenues he has identified (novel sensor surface patterning, electrochemical detection schemes for low resolution HLA typing). In addition, the researcher proposes to continue the successful development of a microfabricated genosensors array, focusing on sensor and microfluidics integration as well as connectivity issues (on chip integration and assay (HLA typing in &lt;15 minutes)). Finally, more emphasise should be brought on the consideration of regulations and commercialisation considera

Keywords: clinical analysis,diagnostic,celica disease,electrochemistry,surface chemistry,biophysics,surface physics,nanobiotechnology,measurement technology,biosensor,optics,microfluidics,microfabrication
Visual Prosthesis: From Clinical Trials to the Psychophysics Lab and Back (VISUAL PROSTHESIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-08-01
End date: 2013-07-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

A bionic eye that provides sight to blind people is now feasible. The implant creates a perception of vision by electrically stimulating the retina of a blind patient. There are several groups that are currently conducting clinical trials to test the safety and efficacy of visual prosthesis devices. So far, clinical trials have shown no safety issues and therefore, visual prostheses will probably receive market approval in the near future. As of now, there are no acceptable procedures to quantify the new kind of vision provided by these visual implants. The vision achieved from the implant is indeed artificial, of low resolution, and differs from natural human vision. Therefore, one cannot use visual acuity procedures that are used for seeing subjects. For example, due to the prosthesis&apos; narrow field of view, subjects must continuously scan the visual field using head or eye movements. As a result, viewing time is a major factor when measuring the functionality of the bionic eye. In contrast, time is not a critical factor in visual acuity testing of seeing people. The aim of this proposal is to develop tools that will assess the visual functionality benefits of visual implants designed to help severely visually impaired patients, i.e., those who are totally blind. Although the end point of the visual functionality of these therapies is a far cry from natural sight, the restored vision will significantly improve the quality of life of blind patients that currently do not have any alternative treatment. These implants have already radically affect the visual experiences of several patients. For example, blind subjects experience great happiness when perceiving visual information of family members. Herein, I propose to extensively research and develop tools that will measure and quantify implants&apos; artificial vision. Quantification of artificial vision acuity will lead to better devices that will hopefully bring light to thousands of blind people.

Keywords: ophthalmology,biomedical engineering,visual prosthesis,visual acuity,visual reality simulator,psycho physics