Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DEVELOPMENT OF A MULTIFUNCTIONAL BIOMATERIAL PATCH FOR BUCCAL DELIVERY OF PEPTIDE-ANALOGUE TREATMENTS (Hop on action) (BUCCAL-PEP-Hop on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Ireland,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 48.0
Total project cost (EUR): 614647.5
EU funding (EUR): 599647.5
Participants: 2
Project status: SIGNED

Oral delivery of peptide-analogues (a macromolecule) is one of the great challenges in pharmaceutical research. Thus far, only five peptide-analogues have been converted to oral formulations such as tablets/capsules and all face distinct challenges including low bioavailability, dosage control, patient administration inconvenience and restrictions in use (e.g. undesirable food interactions). The BUCCAL-PEP consortium has joined hands to develop a multifunctional biomaterial patch which allows, for the first time, buccal (in the cheek) delivery of peptide-analogue therapies, thereby overcoming these challenges through unique integration of a permeation enhancer (SDC) with biomaterials and a peptide-analogue. The novel formulation enables peptides to diffuse across the mucosal multilayer, thereby effectively achieving their intended pharmacological response. The novel approach will result in an improved quality of patient life and increased treatment compliance. With this HOP ON project, UNIVERSIDADE DE AVEIRO proposes the development of highly innovative adhesive materials to wet environments based on the spontaneous coacervation of a polyphenol with natural-based polymers, to complement the materials already proposed by the consortium for the mucoadhesive and middle layers. Together, the consortium will design, select and manufacture a lead product (with Type 2 Diabetes as showcase indication) that will be validated for performance in in vivo large animal studies. Additionally, a Health Technology Assessment will be performed. The final deliverable of the project is a patch that is pre-clinically validated and ready for clinical trials in the desired showcase indication. Overall, the BUCCAL-PEP project will provide a platform technology for oromucosal delivery of peptide-analogues that will be suitable for a broad range of experimental- and approved peptides-analogues therapies across a multitude of disease indications.

Keywords: buccal administration,peptide analogue delivery,oral patch,type 2 diabetes
Advanced computing, quantum algorithms, and data-driven approaches for science, technology and engineering (AQTIVATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Cyprus,France,Italy,Sweden,Germany
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 3891441.6
EU funding (EUR): 3891441.6
Participants: 19
Project status: SIGNED

The joint doctoral project “Advanced computing, QuanTum algorIthms and data-driVen Approaches for science, Technology and Engineering (AQTIVATE)” will deliver an interdisciplinary training program for fifteen fellows who will learn to utilise high performance computing, develop scalable algorithms and machine learning approaches, and explore quantum computing for research projects from physics, engineering and biology. AQTIVATE engages nine degree awarding institutions (DAIs) and four major research centres, including four national supercomputing centres in Cyprus, Germany, Italy and Sweden, one non-degree higher-educational institution, five companies as associated partners, NVIDIA participating through its research labs at two supercomputing centres, and IBM to join as a future associate partner. AQTIVATE will deliver joint degrees between at least two DAIs. The training program and the research projects of the fellows are designed to be interdisciplinary and they all include a placement in industry and/or supercomputing center, exposing the fellows to different training and work settings. By integrating interdisciplinary methodologies and engaging leading experts from different fields across Europe, AQTIVATE aims to deliver an innovative doctoral program that goes beyond what can be delivered by a standard university curriculum. This combination of formal and hands-on training, coupled with an exposure to different training environments, aspires to produce graduates with excellent career prospects both in academia and industry, and who will be ideally positioned to develop disruptive approaches in their respective scientific fields. AQTIVATE responds to the advancements and investments in supercomputing infrastructure and quantum computing systems and the need for developing new algorithms and software, delivering the much needed human capital that is essential to ensure Europe’s leadership in exploiting digital technologies for research and innovation.

Keywords: lattice gauge theories,lattice qcd,computational fluid dynamics,quantum algorithms
Multi-Attribute, Multimodal Bias Mitigation in AI Systems (MAMMOth)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Greece,Austria,Italy,Netherlands,Ireland,Spain,Lithuania,United Kingdom,France,Cyprus,Germany
Call: Tackling gender, race and other biases in AI (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 3304975.0
EU funding (EUR): 3304975.0
Participants: 13
Project status: SIGNED

Artificial Intelligence (AI) is increasingly employed by businesses, governments, and other organizations to make decisions with far-reaching impacts on individuals and society. This offers big opportunities for automation in different sectors and daily life, but at the same time it brings risks for discrimination of minority and marginal population groups on the basis of the so-called protected attributes, like gender, race, and age. Despite the large body of research to date, the proposed methods work in limited settings, under very constrained assumptions, and do not reflect the complexity and requirements of real world applications. To this end, the MAMMOth project focuses on multi-discrimination mitigation for tabular, network and multimodal data. Through its computer science and AI experts, MAMMOth aims at addressing the associated scientific challenges by developing an innovative fairness-aware AI-data driven foundation that provides the necessary tools and techniques for the discovery and mitigation of (multi-)discrimination and ensures the accountability of AI-systems with respect to multiple protected attributes and for traditional tabular data and more complex network and visual data. The project will actively engage with numerous communities of vulnerable and/or underrepresented groups in AI research right from the start, adopting a co-creation approach, to make sure that actual user needs and pains are at the centre of the research agenda and act as guidance to the project’s activities. A social science-driven approach supported by social science and ethics experts will guide project research, and a science communication approach will increase the outreach of the outcomes. The project aims to demonstrate through pilots the developed solutions into three relevant sectors of interest: a) finance/loan applications, b) identity verification systems, and c) academic evaluation.

Keywords: fairness,discrimination,multi discrimination,networks,multimedia,loan approval,face verification
AI and Process Automation for Sustainable Entertainment and Media (EMERALD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Spain,Germany,Ireland,Portugal,United Kingdom
Call: AI, Data and Robotics for Industry optimisation (including production and services) (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2022-DIGITAL-EMERGING-02, 2022)
Start date: 2023-10-01
End date: 2026-03-31
Duration (months): 30.0
Total project cost (EUR): 2689186.25
EU funding (EUR): 2191223.75
Participants: 7
Project status: SIGNED

EMERALD is a 30-month IA to develop and demonstrate exemplary tools for the digital entertainment and media industries using AI Machine Learning and Big Data technologies, to automate and speed processing, increase production efficiency, use less energy and increase the quality of content. There is a massive increase in the volume of video-based and extended reality content, with an unsustainable demand for skilled human resources, data processing and energy. EMERALD aims to meet the challenge by developing process automation for sustainable media creation; creating a testbed for measuring the energy used in media computation; developing more efficient data use for AI/ML in entertainment and media applications; reducing the power demands for large-scale media data processing; and creating acceptance and demand for AI and sustainable production technologies in the entertainment and media industries. The interdisciplinary Consortium of seven partners includes leading companies from the movie, broadcast, streaming and live entertainment technology sectors, supported by two major European universities.

Keywords: artificial intelligence,big data,machine learning,process automation,sustainability,environment,energy reduction,media,extended reality,virtual production
Silicon/Copper Oxide Tandem for Standalone CO2 Reduction (SCCORE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

SCCORE aims to advance the European Green Deal’s goals by developing innovative solutions for CO2 removal. The project focuses on creating a wireless tandem photoelectrode structure that integrates a silicon (Si) photoanode with a copper(I) oxide (Cu2O) photocathode, enhanced by optimized catalysts for bias-free and efficient photoelectrochemical (PEC) CO2 reduction to ethylene and glycerol oxidation to dihydroxyacetone (DHA). By leveraging interdisciplinary approaches, SCCORE seeks to overcome the limitations of current PEC systems, which are often reliant on unstable, expensive, toxic, and lab-scale photoelectrodes with low efficiency. The project is dedicated to designing cost-effective, stable, and efficient photoelectrodes that absorb the entire solar spectrum, maintain long-term stability, and are scalable for industrial application, all while using earth-abundant and non-CMR materials. This development will be a significant step towards commercializing PEC cells, contributing to the creation of sustainable and economically viable renewable energy technologies.

Keywords: co2 reduction,standalone photoelectrochemical cell,tandem structure,silicon,copper oxide,stable photocathode,scale up,
The Silk Route Across the Alps. Craftsmen Migrations, Commercial Exchanges & Social Relations Between France & Italy in the Early Modern Period (SILKRAA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2027-02-28
Duration (months): 42.0
Total project cost (EUR): 308286.72
EU funding (EUR): 308286.72
Participants: 4
Project status: SIGNED

My research project aims at reconstructing the dynamics of the migration of silk weavers between Italy and France during the early modern age. To do so, an interdisciplinary approach will be put in place that brings together socioeconomic history, migration, labor and gender studies, history of techniques and material culture. Combining macro-historical, micro-historical and biographical reconstruction it will be possible to participate in the renewal of studies of migratory phenomena in the Early Modern period. By using digital humanities, a database will be created. It will collect both demographic data, biographical information and visual and material evidence from Italian and French museums to answer questions such as: What is the balance between attraction/repulsion policies and integration/emargination dynamics? Who is the migrant artisan and why does he migrate? What contribution does migration bring to the country of arrival and the country of departure? The investigation of this subject will demonstrate that professional migrations played a key role in the success of the European silk industries in the old regime. Training in Italian and international historical research methods, and a close dialogue with historians and experts will be crucial for the realization of the project. The results achieved will play a crucial role both in terms of academic results and societal impact. Through the publication of articles in scientific journals, participation in conferences and the organisation of lectures and seminars, the results of the project will be widely disseminated. In addition, extensive communication activities are planned (social networking, meetings with the general public and participation in events organised by the European Union). This project will represent an important starting point for my introduction into the academic field, allowing me to expand my skills and my network of knowledge through both European and non-European collaborations.

Keywords: italy france silk weaving early modern history craft guilds digital humanities know how social variables textile history material culture
Regulation of mRNA homeostasis by Poly(A) binding proteins (RNAhome)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

RNA is a biomolecule central to all life forms, and cells regulate RNA production and degradation rates to maintain stable RNA concentrations (RNA homeostasis) through a largely unexplored mechanism. Increasing evidence indicates that a feedback mechanism coordinates mRNA synthesis and degradation, allowing cells to buffer mRNA concentration. For the coordination of these processes, I hypothesise the existence of a “sensor” that “measures” mRNA concentration and conveys this information to the transcription and/or degradation machinery, establishing a coordinated response. Cytoplasmic Poly(A)-binding proteins (PABPCs) are highly conserved across eukaryotes, and specifically bind to polyadenylated mRNAs, regulating their stability, translation, and degradation. Several properties of PABPCs, such as nuclear shuttling and transcription inhibition in response to viral infection, make them ideal candidates as mRNA sensors, yet it is unclear whether they control mRNA homeostasis in physiological conditions. RNAhome will characterise the role of PABPCs in mRNA buffering and homeostasis using a systemic approach. I will conduct PABPC titration, followed by metabolic labelling and multiplexed imaging, to analyse RNA dynamics in response to varying PABPC expression and localisation. I will use my extensive expertise in nanoinjection to introduce mRNA into live cells and assess if PABPCs can directly sense mRNA levels and modulate transcription/turnover accordingly. Finally, I will use SLAMseq to measure genome-wide RNA dynamics with transcript-level resolution, establishing the impact of PABPC expression on mRNA dynamics. RNAhome is a prime example of interdisciplinary science, combining the researcher’s expertise in bio-nanotechnology and physical sciences with RNA dynamics knowledge of the host group, and world-class facilities of the host organisation to unravel the fundamental mechanisms governing RNA homeostasis and drive innovation in RNA-based technologies.

Keywords: rna metabolism rna dynamics rna buffering homeostasis poly a binding proteins scaling transcription turnover modelling
Exploring the Holobiont concept through a Plant Evolutionary Experiment study (HoloE2Plant)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-04-01
End date: 2028-12-31
Duration (months): 81.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The evolutionary processes underlying interactions between hosts and their associated microbes is a black box on which biologists have long attempted to shed light. A limiting factor has been knowledge of the precise molecular events, which are now increasingly possible to elucidate with the advent of next-generation sequencing technologies. The Big Data era have revolutionized evolutionary studies through sequencing of thousands of genomes allowing tracing genomic changes. Coupled to these technologies experimental evolution transformed evolution from a predictive to a functional science by opening a window on evolutionary changes in real-time. The challenge that now awaits evolutionary science is in identifying the trajectories simultaneously driving evolution in hosts and microbes. In this context, HoloE2Plant will validate the holobiont concept by looking at the simultaneous evolution of the host and its microbiome. This will be possible thanks to an experimental coevolution approach applied to fast-cycling Brassica rapa plants and Synthetic Microbial Communities (SynComs). SynComs will be selected from bacterial and fungal collections previously established from wild B. rapa populations. This ambitious project is timely and feasible thanks to the combination of high-throughput sequencing, cutting-edge modelling methods for microbial functional network reconstruction and a novel co-evolutionary quantitative genetic approach that will be developed here. Experimental evolution will be carried out in presence/absence of the fungal pathogen Rhizoctonia solani and the genetic bases underlying microbial-plant interactions and associated with disease resistance will be identified. HoloE2Plant will contribute to validating the holobiont concept and will provide unique methods to identify rapid evolutionary changes in holobionts; these theoretical advances will set the stage for future applied projects aiming at designing microbial consortia with biocontrol properties.

Keywords: experimental evolution,plant microbe interactions,coevolution
Targeted Immunocytokines by CaGing and local Release (TIGER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Immune therapies have caused a paradigm shift in the treatment of melanoma and leukemias. However, the broad Immune therapies have caused a paradigm shift in the treatment of melanoma and leukemias. However, the broad application of these immune therapies to all cancers has not worked. One of the major reason for this failure is the presence of innate immune suppressive cell types in many tumour types, such as macrophages, NK-, dendritic, and myeloid cells. Tumour selective reactivation of these cells is considered one of the holy grails for the future of immune therapy. Most endeavours in achieving this are severely hampered by the toxicity of innate immune activators: they cause strong off-site-on-target systemic immune activation, which can lead sepsis-like symptoms and death. Developing innate immune activating therapies that are both powerful and safe are therefore key to applying immune therapies across the cancer landscape. As part of my ERC-CoG-Grant I have developed innnate immune activators that are chemically blocked, but that can be reactivated locally to offer. This approach can potentially serve as exactly the safe and potent innate activator required. By targeting the innate activators to the tumour and only activating them once they have accumulated there, we can decouple the therapeutic activity from the systemic toxicity that plagues these approaches. In this proposal, we aim to evaluate the first such a caged innate immune activator in a pre-clinical cancer model. We will validate its potency, pharmacokinetics and caging/decaging behaviour. In addition, we will broaden the scope of the innate activators, antibodies and uncaging chemistries that can be applied. We will also perform market research to determine the optimal tumour-immune activator-antibody combination to take forward into clinical development and begin to take the necessary steps to spin out a company based on this work to bring these non-toxic innate activators to the clinic.
Real-time spectral prediction of the brain during General Anesthesia (AnalysisSpectralEEG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

A general methodology based on modeling, data processing and classification is still lacking to predict the brain response to sedation during anesthesia. In this project, we propose to develop a mathematical approach of the brain signal revealed by EEG behavior. We will use modeling to identify features present in frequency bands, to predict the brain response. Using spectral analysis, we will study the time-frequency of the dominant frequency band of the EEG signal. We propose to develop algorithms dedicated to study the brain dynamics based combining transient motifs of the EEG signal. Finally, the present approach will be tested in different hospitals for adults and children. We will specifically focus on predicting the depth of anesthesia. To conclude, the present method could provide new tools to practitioners to prevent deep sedation and possible post-anesthetic complications.