Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Analysis of Bosonic Systems with Long-Range Interactions: the Gravitational and Dipolar cases (BosLong)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Poland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 179006.16
EU funding (EUR): 179006.16
Participants: 1
Project status: SIGNED

This project addresses the effects of thermal particles on the condensate phase for bosons, focusing on systems with long-range interactions at finite temperatures. We explore ultra-light bosonic particles as dark matter candidates in cosmology and extend the study to cold atomic systems under dipolar interactions. Our approach involves a recently developed theoretical framework using non-equilibrium quantum field theory to describe two-component bosonic systems, condensed and thermal, under long-range interactions. We will create a specialized simulation code to study the dynamics of condensate and thermal particles in both cosmological and atomic contexts. This code aims to fill critical gaps in current research and will be made publicly available with detailed documentation. The project will involve two main objectives: (1) developing and validating this code, and (2) investigating pivotal problems in the dynamics of dipolar and cosmological quantum gases. By comparing results with existing methods and exploring new phenomena, this research seeks to provide significant advancements and uncover valuable analogies between ultracold atom and dark matter studies.
Locative Games for Cultural Heritage (LoGaCulture)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Ireland,United Kingdom,Portugal,Germany,Italy
Call: Games and culture shaping our society (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 1972097.5
EU funding (EUR): 1972097.25
Participants: 12
Project status: SIGNED

Locative Games are in the process of entering the mainstream, in cultural heritage they can improve access by offering alternative experiences and widening audiences, they can aid in preservation by managing footfall and focusing digital assets, and they can increase engagement and allow visitors to see their heritage in new ways. However, existing design approaches and infrastructures for locative heritage are bespoke and poorly integrated with existing visitor structures. There is also a lack of guidelines on what is ethically desirable in these digitally mediated spaces, and how designers might mitigate against unintended consequences or abuses. This is a barrier to the widespread adoption of locative heritage applications and means that more complex experiences are currently not sustainable in the wider sector. LoGaCulture will change this by bringing together the leaders in digital locative games, in collaboration with some of Europe’s most significant cultural institutions, to enable a new generation of locative cultural heritage games through proposals for design guidance, validated ethical frameworks, and an open, extensible, and reusable set of technologies. Through a set of five interlinked case studies across four countries the project will: gather evidence from the heritage design space for interactivity, narratives, and play; look at how augmented reality and soundscapes can affect visitors’ immersion; explore the place of locative heritage in the wider visitor journey through transmedia and social visiting; and explore how the barrier to authoring and deploying such systems might be lowered. The goal is to create a step change in knowledge in how to design, deploy, and maintain locative heritage games, and lay the groundwork for their mass adoption by cultural institutions by allowing them to treat locative experiences that offer new forms of access and engagement as an integrated part of their existing cultural heritage work.

Keywords: locative games,cultural heritage,access,engagement,experience design,digital ethics
IRON-BETA - Unraveling the iron metabolism of pancreatic β-cells (IRON-BETA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1498000.0
EU funding (EUR): 1498000.0
Participants: 1
Project status: SIGNED

Iron is a critical cofactor for proteins and enzymes involved in oxygen and energy metabolism, functions that are especially vital in pancreatic β-cells. In these cells, iron is indispensable for mitochondrial respiration, the process that powers insulin production. However, disruptions in iron homeostasis - whether through deficiency or overload - have been linked to β-cell dysfunction, yet the underlying mechanisms remain poorly understood. With IRON-BETA, I seek to unravel how iron metabolism regulates β-cell identity, function, and survival, under both normal and stressed conditions, such as type 2 diabetes (T2D) and early post-transplant ischemia. Using cutting-edge techniques and models, including multiplex single-cell RNA-Seq, super-resolution microscopy, ICP-mass spectrometry, novel genetic mouse models, and iPSC-islet cell differentiation, I, together with my team, will comprehensively explore the role of iron in β-cell biology. We will map iron distribution in islet cells, particularly β-cells, to understand its impact on their function and overall islet health. We will investigate how fluctuations in iron availability contribute to β-cell dysfunction in T2D, with the aim of identifying novel therapeutic targets. Additionally, we will optimize iron supply during the maturation of iPSC-derived β-cells to enhance their functional capacity for cell-based therapy. Finally, we will explore the interplay between iron and oxygen homeostasis in β-cell grafts, focusing on hypoxia-inducible factor 1-alpha (HIF-1α) signaling—a crucial regulatory pathway that integrates both iron levels and oxygen availability. By evaluating how iron deficiency and hypoxia impact β-cell survival and graft success during islet transplantation, we aim to improve transplantation outcomes and advance therapeutic strategies. By addressing these critical gaps in understanding iron homeostasis, IRON-BETA will open new avenues for treating T2D and advance β-cell replacement therapies for T1D.

Keywords: diabetes,iron metabolism,islet transplantation,cell,pancreas
Mechanisms of Kaposi's sarcoma herpesvirus replication and maintenance during latency (KAPTION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1494774.0
EU funding (EUR): 1494774.0
Participants: 1
Project status: SIGNED

Oncogenic viruses are the third most common cause of cancer in humans. Kaposi’s sarcoma herpesvirus (KSHV) is an oncogenic virus that establishes life-long latent infection and can drive tumor development in immunocompromised individuals. To date no definitive treatment against KSHV has been developed and KSHV-derived cancers are uncurable. Despite the advances in understanding KSHV biology, many key aspects are still obscure, and detailed mechanistic studies are needed for the development of rational targeted therapies. During latency, KSHV exploits the host cell’s replication and segregation machineries to faithfully copy and transmit its genome during cell division. Which cellular proteins contribute to these processes and what mechanisms enable the virus to preserve its genome over time remain poorly dissected. I will remodel the Xenopus laevis egg extract in vitro system, which has been successfully applied to study eukaryotic replication and chromosome segregation, to incorporate the key components of KSHV maintenance and generate a unique tool to dissect the mechanisms of KSHV latency in a test tube. With this innovative system in hand and strong of a previously developed powerful mass-spectrometry workflow for protein identification, my group will overcome the limitations of the current methodologies to answer two main questions. (1) What is the extent of the host’s proteome that contributes to KSHV maintenance? (2) What are the molecular mechanisms that drive faithful segregation of the viral genome? Corroborated by parallel experiments in KSHV infected cells, these ground-breaking findings will answer long-standing questions on the latency of KSHV, setting a solid base for the development of targeted therapies. Furthermore, the newly developed latency system in Xenopus egg extract will emerge as a powerful tool for solving puzzling aspects of the biology of other latently infecting viruses.

Keywords: dna replication,xenopus egg extracts,g quadruplexes,viral latency,dna repair,mass spectrometry
Phylogenetic Lexification: Patterns of meaning through time (PhLex)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: TERMINATED

In historical linguistics, scholars often grapple with limited data. Nearly half of the world's ~7,000 languages are endangered. Many of these languages are under-documented, often reduced to mere short wordlists. This is a pressing challenge, as the scarcity hampers our ability to understand linguistic evolution and diversity. Traditional methods often rely on the form of linguistic units, such as phonemes or morphemes. The PhLex project challenges this by emphasising that semantics, while less explored, is not intrinsically unyielding to analysis. PhLex aims to innovate by incorporating semantic analysis into traditional methods, enhancing both our grasp of linguistic evolution, and thus better utilise under-documented language data. To validate this methodology, the PhLex project will focus on the Oceanic language family, spoken across Polynesia, Melanesia, and Micronesia. The first phase involves creating a comprehensive database that explores how these languages articulate concepts related to the semantic domain of perception, like seeing, hearing, and feeling—an area with notable cross-linguistic variation. Subsequent analysis using advanced statistical models traces the historical evolution of the semantic structures, thus applying ‘phylogenetics’ to ‘lexification’, allowing for a comparative assessment against traditional cognate-only methods. The PhLex project’s ultimate objective is to enhance historical linguistic methods by testing a hybrid model that integrates semantic and cognate-based approaches. This model aims to optimise the use of limited linguistic data to provide a nuanced understanding of language origins and evolution. The project thereby opens a new avenue for determining genetic relatedness between languages, an essential factor in understanding linguistic diversification and aiding language preservation efforts in the face of under-documentation.

Keywords: semantic change,oceanic languages,sensory linguistics,lexification,historical linguistics
Reframing the Relationship between War and Politics with 20th Century Women Thinkers. (POLEM-WO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 2
Project status: SIGNED

The aim of this project is to explore the contribution of women philosophers to twentieth-century political thought. While women’s work is currently being rediscovered in all fields of knowledge, they are still marginalized in the history of political thought, since politics has traditionally been considered a male domain. POLEM-WO: “Reframing the Relationship between War and Politics with 20th Century Women Thinkers” aims to fill this gap in European intellectual history by examining the relationship between war and politics – 'polemos' and 'polis' – in the work of major European thinkers, namely, Hannah Arendt, Simone Weil, María Zambrano, and Rachel Bespaloff. The project will draw on their writings on the most pressing issues of their time – the rise of totalitarianism, the role of Europe, Jewish identity, the reconstruction of a democratic future – to perform a critique of the traditional bond between politics and violence. The result will be an original examination of the European tradition with the aim of producing a renewed political lexicon – one based on hospitality, friendship, vulnerability, plurality, 'xenophilia' – as a conceptual resource for confronting a present challenged by war, the global shift to populist politics and the refugee’s crisis. Using the methods of political theory, gender studies, archival research, and digital humanities, POLEM-WO has a twofold objective: on the one hand, it will point out the gendered nature of traditional political notions, while enlarging the semantical spectrum of politics; on the other hand, it will produce a non-canonical understanding of key categories such as politics, war, peace, and democracy. The project will make its results available to scholars and the public, thus contributing to the strengthening of a diverse and inclusive imaginary within the framework of a shared European identity.

Keywords: history of political thought,political philosophy,contemporary philosophy,contemporary jewish philosophy
EU-CHINA-BRIDGE - Building Roadmaps to Industrial Decarbonisation and Green Economy through EU-China Cooperation (EU-CHINA-BRIDGE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Germany,Greece,Austria,China,United Kingdom
Call: EU-China international cooperation on data and model development for pathways to carbon neutrality: focusing on decarbonisation, energy efficiency and socio-economic implications of the transition (HORIZON-CL5-2023-D1-02, 2023)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 2019271.0
EU funding (EUR): 2019271.0
Participants: 16
Project status: SIGNED

EU-CHINA BRIDGE will support the transition to a climate-neutral and resilient society in both Europe and China by jointly advancing knowledge on technology innovations and roadmaps for decarbonising energy intensive industries, co-creating innovative modelling by combining cutting-edge bottom-up and integrated assessment modelling to quantify net-zero sustainable pathways, and developing the most updated and comprehensive emissions data. It will intensively engage relevant stakeholders from both regions, enhancing dialogues, and fostering mutual learning among policymakers, industries, and experts. It will deliver two open-source EU-China joint technology inventories of promising net-zero emission technology options for the iron & steel and chemical industries, two co-implemented demonstrations of promising technologies in China, and co-created scale-up paths and roadmaps of the selected industrial technologies in both regions. It will also develop the most up-to-date, high-resolution, multi-sectoral, national and regional GHG and short-lived climate pollutant emission inventories as well as dynamic monitoring of key emission sources at high spatiotemporal granularity. A state-of-the-art modelling framework will be developed, exploiting and advancing cutting-edge and established modelling tools for EU and China, using the latest emissions data, representing technology and policy options, enabling assessment of socioeconomic impacts, covering multiple economic sectors and regions, and offering high spatial and technology detail. The enhanced models will be used to co-produce net-zero pathways for the EU and China, explicitly assessing co-benefits and trade-offs of climate policies with other societal goals while exploring cooperation policies and governance to drive the global transformation, and assessing the distributional and global-level implications of the two regions’ decarbonisation. The pathways will be documented in new workspaces in the I2AM PARIS platform

Keywords: net zero technologies,scalling up paths,technology roadmap,net zero pathways,advanced iams,ghg and short lived climate pollutant,emission inventories
Enabling the direct synthesis of multi-functionalized iodoarenes as accessible sophisticated building blocks for sustainable catalytic sequences (Cat4Arene)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

In the last 20 years, palladium-catalyzed C–H activation has emerged as a useful alternative to traditional cross-coupling methods and a powerful tool to access valuable intermediates for the synthesis of complex functional molecules. The biaryl fragment is one of the most frequent units present in bioactive molecules, functional organic materials and natural products. Despite major advances, significant limitations persist with regard to their preparation, in term of reactivity, selectivity and sustainability. Based on the recent achievements in the synthesis of ortho-iodobiaryls following a Catellani strategy, the overall objective of this proposal is the development of a general and sustainable method for the direct synthesis of ortho-iodobiaryls and selectively substituted haloarenes as valuable intermediates for the synthesis of a large number of high value-added compounds. The project aims also to develop protocols for the straightforward synthesis of new biaryl-containing phosphines, as a valuable application of this methodology. CAT4Arene will allow the selective construction of halogenated biaryls and arenes which can be further easily converted into a broad variety of high value-added compounds. In particular, thanks to the easily manipulation of the C-halogen bond, especially C-I and C-Br bonds, these new methodologies will unlock the direct construction of tricky molecular architectures, including biaryl-containing phosphines and bioactive nitrogen derivatives. Likewise, new classes of organic molecules would be also accessed, unlocking the opportunity to enlarge the range of compounds available for the medicinal chemistry and the agrochemical industry. The development of unconventional haloarenes formation protocols will be an outstanding breakthrough for the organic chemistry community.

Keywords: catellani reactions,palladium,c c catalytic couplings,iodoarenes,biaryls
Digitalization of Cultural Heritage as Discursive Practice: Mapping the Museums and Citizens-led Initiatives in Graz and Novi Sad (DISCULTHER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-02
End date: 2025-10-01
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: CLOSED

Digitalization of Cultural Heritage as Discursive Practice: Mapping the Museums and Citizens-led Initiatives in Graz and Novi Sad (DISCULTHER) examine how the process of digitalization of cultural heritage (DCH), identified on a discursive level, manifests in two kinds of settings: institutional (museums) and activist (citizens-led initiatives). The main objective of the project is to investigate the plurality of discursive practices of DCH within mentioned settings, the innovativeness, discrepancies and tensions in these practices, as well as the capacity of DCH to make accessible, mobilize and critically engage citizens in opening the space for intercultural dialogue. It is a project with comparative dimension on two levels: it compares the institutional with non-institutional practices of DCH, but also the processes in two cities, Novi Sad (Serbia) and Graz (Austria). They share in part the common history, culture and heritage. In contemporary framework, comparison aims to highlight social and cultural experience of the cities of which one belongs to the state member of European Union and one is in the process of Europeanization. It is also interdisciplinary research that transcends the boundaries in Social Sciences between Sociology, Heritage Studies and Digital Humanities and foregrounds hitherto neglected aspects of the process of digitalization of cultural heritage.

Keywords: digitalization,cultural heritage,discourse,museum,activism,europeanization