Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Building Next-Generation Brain/Neural-Machine Interfaces For Restoration of Brain Functions (NGBMI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-11-01
End date: 2024-10-31
Duration (months): 72.0
Total project cost (EUR): 1498125.0
EU funding (EUR): 1498125.0
Participants: 2
Project status: SIGNED

Today, five out of ten diseases worldwide resulting in long-term disability are related to the central nervous system. Due to the immense complexity and inter-individual variability of the human mind and brain there are still no effective and side effect free treatment options for many serious neuropsychiatric disorders, such as major depression, dementia or schizophrenia. Recent advancements in sensor technology and computational capacities resulted in the development of brain/neural-machine interfaces (B/NMIs) that translate electric, magnetic or metabolic brain activity into control signals of external devices, robots or machines. Moreover, novel transcranial magnetic and electric brain stimulation (TMS/TES) systems were developed allowing for direct modulation of brain activity. However, current B/NMIs are limited by the low information extraction rate constraining fluent direct brain-machine interaction. Furthermore, as simultaneous assessment of brain oscillations during TES was regarded unfeasible due to stimulation artefacts, current TES systems can only deliver “open-loop” stimulation unrelated to the underlying dynamic brain states resulting in highly variable TES effects. Building on the applicant’s previous work that includes pioneering work on in vivo assessment of brain oscillations during TES (Soekadar et al. 2013, Nature Communications) and full restoration of daily living activities after quadriplegia using a novel B/NMI hand exoskeleton (Soekadar et al. 2016, Science Robotics), the NGBMI project will overcome these limitations by merging both techniques. After developing the first real-time B/NMI-TES system allowing for effective modulation of brain functions and fluent direct brain-machine interaction, the system will be tested in persons with impaired brain function (e.g. depression, dementia or stroke). Finally, the B/NMI-TES paradigm will be implemented in a wireless and wearable EEG-based system that can be used in everyday life environments.

Keywords: closed loop transcranial electric stimulation tes,neural substrates of the human mind,everyday life brain,neural machine interfaces
Overcoming the epigenetic and therapeutic barrier of EVI1-overexpressing cancers (EVI1inCancer)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 1499094.0
EU funding (EUR): 1499094.0
Participants: 1
Project status: CLOSED

Deregulation of the EVI1 oncogene is a key transforming event in the development of many malignancies, most prominently very high-risk acute myeloid leukemia (AML), ovarian, colon, breast, non-small cell lung cancer, and soft-tissue sarcoma. For decades, both EVI1 function and the mechanism underlying its deregulation have been poorly understood. The consequent lack of a targeted therapy against EVI1 establishes a pressing medical need. In a recent study investigating a distinct category of EVI1-driven AML with inv(3) or t(3;3), we characterized the regulatory domain of EVI1 and identified a master regulatory element of the stemness factor GATA2 to be rearranged to EVI1, thereby deregulating both genes. Applying functional genomics and genome-editing, we found that the rearranged enhancer element adopted novel features, such as superloading of the epigenetic reader and chromatin regulator BRD4, allowing its inhibition with BET/bromodomain inhibitors with relative EVI1 specificity. Interference with EVI1-regulatory mechanisms thus has potential therapeutic value in EVI1-transformed tumors. To pave the way for epigenetic targeting of other EVI1-expressing malignancies, we aim to identify genomic enhancer sequences and protein components of the EVI1 regulatory domain by systematic epigenetic and proteomic profiling. Specifically, we seek to achieve the following experimental goals: (1) Identification of the mechanism underlying EVI1 deregulation in non-3q-rearranged AML and solid tumors; (2) Addressing the role of breakpoint-associated transpos-able retroelements; (3) Characterization of the transcription factor complex regulating EVI1; (4) Identification of epigenetic resistance mechanisms in EVI1+ AML by using an in vivo model and a genome-editing approach. The proposed experiments will provide insight into the epigenetic landscape of EVI1+ malignancies and help reveal new targets and genetic interactions amenable to future therapies in these high-risk malignancies.

Keywords: evi1,leukemia,crispr,cas9,chromosome conformation capture sequencing
Bringing social impact to markets - Social Impact rating agency and AI powered SaaS tool for investors to optimize the social impact of their investment portfolios. (CLARITY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2020-02-29
Duration (months): 18.0
Total project cost (EUR): 3511288.75
EU funding (EUR): 2457902.13
Participants: 1
Project status: CLOSED

Clarity is a highly innovative tech company offering an end-to-end solution that optimizes the social impact of the investment portfolios of our clients, mainly investment management firms, in a HUGE MARKET (currently more than $23 trillion sustainable investments - one third of the total market) growing at 25% CAGR. Our TECHNOLOGY is based on disruptive use of big data and machine learning algorithms and a proprietary and innovative social impact methodology, developed by excellent researchers educated at top Universities from Spain (UPM, UCM) and USA (Harvard, MIT). Clarity UNIQUE VALUE PROPOSITION is based on: ● More accurate and comprehensive social impact measurement ● Automatic portfolio rebalancing to maximize social impact without compromising financial performance ● Excellent user experience ● Highly scalable and flexible SaaS business model with affordable pricing Our PRODUCT has already been tested by top CLIENTS managing more than €200 Billion, we have firm commitment of 8 more clients, (who manage more than €7 trillion in assets) and additional 30+ asset managers interested in testing it. Our tool has also been praised and supported by top experts in our key sectors, including United Nations, World Bank, World Economic Forum, Cambridge Associates, Gartner, BCG, McKinsey and Bain. We have an exceptional TEAM and detailed strategy and EXECUTION PLAN. We have recently closed a first round of €1.4Mn+ and secured commitments from other venture capital investors. In addition, we have been awarded €250K in equity-free funding by the EU Impact Growth program (selected among more than 1,900 startups) and €208k equity-free funding by NeoTec to most innovative Spanish startups. Currently, we are ready to SCALE-UP internationally by improving our social ratings and algorithms, and scale our SaaS tool to other top investment managers globally. The SME instrument phase 2 will support us to make a European company the World leader in this new growing market.

Keywords: social impact,sustainable investing,asset management,investment,saas,big data,machine,learning,cloud services,enterprise software,advanced ux
Advancing cell based therapies by supporting implant survival (ENABLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Tissue engineering aims at the creation of living implants to replace, repair, or regenerate damaged, diseased, or aged tissues, which holds tremendous possibilities to both extend our lives and improve our quality of life. During the last decades, our ability to create small tissues to heal small animals e.g. mice and rats has taken a breath taking leap. However, we have relentlessly struggled to create viable tissues of human-relevant sizes. Creating solid large tissues imposes lethal nutrient diffusion limitations, which causes the living implant to suffer from starvation, loss of function, and inevitable failure. I hypothesize that this key challenge can be tackled by recruiting and developing advanced enabling nano- and micro-technologies. The ENABLE project begins with the design and development of a widely applicable platform that will enable large solid engineered tissues to survive and function by actively sustaining the implants metabolic needs. This platform is based on a unique two pronged strategy that rely on distinct technologies: oxygen releasing micromaterials, fabricated using a next-generation droplet generator, to enable short term survival of the implant, while embedded bioprinting will endow implants with a complex 3D vascular network to enable their long term survival. As proof of principle, the effects of ENABLE’s platform will be investigated using a critical bone defect in which I analyse the survival and function of the created living implants. The anticipated outcomes of this proposal are three fold: first, I will develop a next-generation engineered tissue that will overcome the current size restrictions via the use of enabling technologies; second, I will reveal new knowledge on the role of the oxygen tension on vascularization and tissue formation by enabling control over the in vivo oxygen tension; and third, I will develop a novel strategy that enables the treatment of critical bone defects.
Integration of volatile cues and plant peptide signals for enhanced herbivore resistance in tomato (InteCue)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Plants are often exposed to infestation by insect herbivores. How do they defend themselves to grow and reproduce? We know that plants can perceive volatile cues, emitted by insect infested neighboring plants, to generate faster and stronger defense responses upon subsequent herbivory. Plants can also sense peptide signals, induced by herbivory, to fight against herbivores. However, we know close to nothing about whether plants can integrate volatile cues and peptide signals for enhanced herbivore resistance. In InteCue, I will determine the capacity of tomato plants to integrate herbivore-induced plant volatiles (HIPVs) and the peptide systemin for enhanced defense responses against herbivores. I will also assess the direct impact of HIPVs on systemin signaling. Finally, I will explore the role of the systemin receptor SYR1 as a hub for HIPVs-systemin signal integration and regulation. As such, I aim to unravel the molecular mechanisms underpinning volatile and plant peptide signal integration and regulation in the context of plant-herbivore interactions. By combining my knowledge of peptide signaling, the expertise of chemical ecology and the unique platform for high throughput volatile profiling from the host lab, InteCue will advance our understanding of signal integration in plant-herbivore interactions. Ultimately, the new knowledge gained will lay the foundation of breeding pest resistant crops for sustainable agriculture.

Keywords: plant herbivore interactions,herbivore induced plant volatiles,systemin,plant immunity,signal integration
EEN Innovation Support Services for SMEs in North West Italy (ALPS INN3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 267912.5
EU funding (EUR): 267912.0
Participants: 8
Project status: CLOSED

The project, whose geographical coverage will be North-West Italy (3 regions : Piemonte Liguria and Valle d’Aosta) aims at providing and upgrading a specific framework service for supporting SMEs in the innovation management capacity . The service will be directed to SMEs with international growth potential via product, process service and or business model innovation- with gaps regarding innovation management. In particular, the action will focus on the following specific objectives: 1. Fine tuning of a Key Account Management based customised service provision directed to: a. SMEs /Scale ups international growth, including participation to European programs b. SMEs Innovation capacity enhancement and innovation projects implementation, job creation and new market access c. SMEs Innovation results exploitation 4. Integration of the service within local business innovation support delivered, EEN specific service official embedding within the regional innovation ecosystem 5. Advisory skill enhancement: ALPS EEN personnel, assisting the experts in this Action, will increase expertise and competences, providing high level advisory on innovation management 6. Upgrading a EU shared support methodology for EEN staff, which could be adopted for profitably supporting other local SMEs 7. Contribution to the enhancement of a visible and well identified Coach/EEN experts community at EU level 8. Updating the operational internal manual/chart for a harmonized service within the EEN ALPS Consortium and contribution to definition of a common EEN operational manual

Keywords: innovation management,eic pilot,scale up,growth,innovation results,research results exploitation,internationalisation,innovation strategy,digitization
High-Performance Advanced Methods and Experimental Investigations for the Safety Evaluation of Generic Small Modular Reactors (McSAFER)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Argentina,Germany,Finland,Sweden,Belgium,Finland,France,Czechia,United Kingdom
Call: Support for safety research of Small Modular Reactors (NFRP-2019-2020, 2019)
Start date: 2020-09-01
End date: 2024-02-29
Duration (months): 42.0
Total project cost (EUR): 4045133.75
EU funding (EUR): 3995982.5
Participants: 13
Project status: SIGNED

The main objective of the McSAFER project is the advancement of the safety research for Small Modular Reactors (SMR) by combining dedicated experimental investigations and numerical simulations. Experiments will be performed on existing European thermal hydraulic test facilities to investigate SMR-specific safety-relevant phenomena (subcooled boiling, critical heat flux). The main objective of the McSAFER project is the advancement of the safety research for Small Modular Reactors (SMR) by combining dedicated experimental investigations and numerical simulations. Experiments will be performed on existing European thermal hydraulic test facilities to investigate SMR-specific safety-relevant phenomena (subcooled boiling, critical heat flux, transition from forced to natural circulation) with the goal providing corresponding data on code validation. Advanced computational tools developed and partly validated in the European projects NURESAFE, HPMC and McSAFE, will be used to conduct the neutron physical, thermal hydraulic and thermo-mechanic analysis of the reactor core of different SMR design. In the next step, multidimensional and multiscale methods will be applied to the analysis of the processes inside the reactor pressure vessel. Finally, different numerical tools (conventional, low order and high fidelity) will be applied to demonstrate the inherent safety features of an SMR-core as well as how the SMR-designs under investigation assure the safety function of core sub-criticality and core coolability under postulated design-basis-accident-conditions. The project is a planned as a research and innovation action. Despite the concentration on SMR, the methodology is fully transferable to LWR of Gen-II and -III as well as to Gen-IV reactors due to the versatility of the involved codes. Last but not least, the envisaged project fosters the dissemination of knowledge from experienced researchers to young engineers, scientists as well as master and doctoral students.

Keywords: small modular reactors,safety analysis methods,experimental validation,multiscale,multiphysics,safety research
Role of Educational Systems on Entry Level Wage Differences (GEWADI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Switzerland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 167775.0
EU funding (EUR): 167775.0
Participants: 2
Project status: CLOSED

The gender wage gap has narrowed from the 1960s, mainly due to the increase of female education, work experience and female workforce participation, however, it still remains. Across EU countries, in 2015 women earned on average 16.3% less than men, and this gap has only marginally declined from 18.6% in 2000 . In the US, women working full-time earn just 81.9% of men’s salaries in the same period. The gender wage gap literature can be divided according to their findings at the entry level and along the career path. While the literature agrees that wages grow faster for men than for women throughout their careers, evidence of wage differences at the entry level is mixed. Conclusive evidence about the existence of early wage differences will improve our knowledge of how labor markets work, will help identify the sources of wage discrimination, and will guide policy decisions towards reducing gender differences along the career path. Despite their impact on early-career wage differences, countries’ distinct educational systems and ages of the studied cohorts have not been taken into account in earlier analyses. The aims of this fellowship consist in (a) answering whether gender wage discrimination is present at early career stages, and (b) investigating the role of the educational systems on early wage discrimination. We will estimate the structural parameters of initial wages (intercepts) and their growth rate (slopes) for men and women considering the potential future investments in HC. Using some of the best longitudinal data sets currently available for the US (National Longitudinal Survey of Youth - NLSY) and Switzerland (Swiss Household Panel – SHP, and Longitudinal Analysis in the Field of Training - LABB), we will compare entry level wages and their evolution from two countries with different educational systems (VET and Academic Track).

Keywords: wage discrimination,wage inequality,gender discrimination
Reconstructing the origins of animal multicellularity using experimental evolution (MULTICELLEXPEVO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

All living animals are descended from a single-celled ancestor. Understanding how this ancestor became the first multicellular animal remains a major challenge in the field of evolutionary biology. Phylogenomic analyses have shown that animals are closely related to three unicellular lineages: choanoflagellates, filastereans and ichthyosporeans, altogether forming the Holozoa clade. Genetic and phenotypic studies have shown that the filasterean Capsaspora owczarzaki can under specific growth conditions form transient multicellular aggregates. However, why is this multicellularity only transient? What are the genetic and phenotypic requirements for its emergence and stabilization? And what is the role of the actin cytoskeleton in this transition? Indeed the actin cytoskeleton is known for its pivotal role for cell coordination and morphology, which must play a role in evolution of multicellularity. To address these questions, we will use the C. owczarzaki as a model organism. We will combine cell biology, genomics and experimental evolution to unravel multicellularity emergence and stabilization. Specifically, we will aim to obtain evolved mutants showing excessive and more stable multicellular behaviour of C. owczarzaki using long-term experimental evolution. Such evolved strains would unravel how multicellularity emerged and stabilized. In addition, using random mutagenesis screen, we aim to identify mutants unable to form multicellular aggregates. Such mutants would reveal the minimum genetic requirements for such a transition. Finally, we will take advantage of recently developed genetic tools in C. owczarzaki to study the actin cytoskeleton during the cell cycle. Our results could reveal how the first multicellular ancestor of animals appeared from a genetic and cellular perspective, and, how cell fate specification was established during evolution. Results generated on this fellowship will be relevant to evolutionary, cell and developmental biologists.

Keywords: multicellularity emergence,metazoa,actin organization,experimental evolution