Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Floating Tidal Energy Commercialisation project (FloTEC) (FloTEC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Ireland,Ireland,Germany,Germany,Ireland,Ireland,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Demonstration of renewable electricity and heating/cooling technologies (H2020-LCE-2015-2, 2015)
Start date: 2016-01-01
End date: 2021-08-31
Duration (months): 68.0
Total project cost (EUR): 22044231.5
EU funding (EUR): 9782380.25
Participants: 15
Project status: CLOSED

The FloTEC project will demonstrate the potential for floating tidal stream turbines to provide low-cost, high-value energy to the European grid mix. The FloTEC project has 5 core objectives: 1. Demonstrate a full-scale prototype floating tidal energy generation system for optimised energy extraction in locally varying tidal resources; 2. Reduce the Levelised Cost of Energy of floating tidal energy from current estimated €250/MWh to €200/MWh, through both CAPEX and OPEX cost reductions in Scotrenewables Tidal Technology; 3. Develop potential of tidal energy generation towards flexible, baseload generation, through the integration of energy storage. 4. Demonstrate the potential for centralised MV power conversion to provide a generic, optimised low-cost solution for tidal arrays 5. Progress tidal energy towards maturity and standard project financing by reducing cost and risk, improving reliability, and developing an advanced financing plan for first arrays. This will be realised through the construction of a M2-SR2000 2MW turbine - which will incorporate the following innovations: 50% greater energy capture through enlarged rotors with a lower rated speed; Automated steel fabrication; Centralised MV power conversion Integrated Energy Storage Mooring load dampers Composite Blade Manufacturing The SR2000-M2 will be deployed alongside the existing SR2000-M1 at EMEC to form a 4MW floating tidal array, serving as a demonstration platform for commercially viable tidal stream energy as a baseload supply.
Dissecting the regulatory logic of poised enhancers (PoisedLogic)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Spain,Spain
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1997662.0
EU funding (EUR): 1997662.0
Participants: 2
Project status: SIGNED

The mechanisms that, despite the noisy and stochastic nature of transcription, enable the specific, precise and robust deployment of developmental gene expression programs are poorly understood. We previously identified Poised Enhancers (PEs) as a conserved set of cis-regulatory elements essential for the induction of major anterior neural genes upon ESC differentiation. Importantly, before becoming active in anterior neural progenitors, PEs are already bookmarked in embryonic stem cells (ESC) with unique chromatin and topological features, including binding by polycomb-group protein complexes (PcG) and pre-formed contacts with their target genes. Here I hypothesize that the competence of pluripotent cells to faithfully execute an anterior neural gene expression program is genetically encoded and dependent on the unique modular composition of PEs, consisting of a cluster of highly conserved transcription factor binding sites (TFBS) and a nearby CpG island (CGI). This modular composition might endow PEs with privileged regulatory properties, whereby the TFBS confer cis-activation capacity, while the CGI bestow permissive chromatin and topological features that boost the PEs regulatory activity and increase transcriptional precision. Furthermore, I hypothesize that, together with architectural proteins, this modular composition dictates the specificity, compatibility and responsiveness between PEs and their target genes. Using ESC as a tractable system and genomic, single-cell/single-allele and genetic engineering methods, we will systematically dissect the contribution of each PE module (i.e. TFBS, CGI) and of different epigenetic (e.g. PcG, DNA methylation) and architectural factors (e.g. Cohesin, CTCF) to the regulatory logic of PEs. By systematically dissecting PEs, our work will illuminate novel and general mechanisms whereby enhancer pre-marking facilitates the precise and specific establishment of gene expression programs during vertebrate embryogenesis.

Keywords: enhancers,pluripotency,differentiation,transcriptional precision,polycomb,cpg islands,synthetic engineering
Latin Relics in a Greek Egypt (LAREGRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-08
End date: 2024-02-07
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

LAREGRE takes into account all documentary papyri from IV to VII AD Egypt, which contain passages in the Latin language, be they simple characters, words, phrases, or full texts (about 400 manuscripts). These documents will be investigated within the larger frame of Late Antique Egypt, the Late, and the Eastern Roman Empire. The core questions of this study are i) how the central government (first that of Rome, than that of Constantinople as the Empire fragmented) used the Latin language in the Egyptian provinces to enhance its power and authority; and ii) how people in Egypt reacted to the cultural and political decline of Rome, hitherto the centre of Roman power and the symbol of Western rule. The project addresses sets of documents so far understudied and fills a long-standing gap in scholarship; it stems from my experience as a scholar and interpreter of Latin texts on papyrus within the ERC-funded project PLATINUM (2015-2021), which has contributed to re-assess the historical importance of manuscripts, such as Latin papyri, potsherds or tablets from Egypt and the Mediterranean basin, usually overlooked or understudied. Employed methodologies will combine papyrological and palaeographical analysis on the manuscripts – which will be greatly improved at the Center for the Tebtynis Papyri in Berkeley – with historical investigation on the texts and contexts gathered from those very manuscripts, to be decidedly enhanced by the final year of the Fellowship at the DISCI in Bologna. The success of this project will improve my professional profile into a more complete scholar, and will boost my chances of getting a tenure-track position within the DISCI itself.
Unravelling the physics of particle acceleration and feedback in galaxy clusters and the cosmic web (ClusterWeb)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1487755.0
EU funding (EUR): 1487755.0
Participants: 1
Project status: SIGNED

We will unravel the origin of cosmic magnetic fields, the physics of particle acceleration in dilute plasmas, and the nature of AGN feedback with state-of-the-art radio telescopes. With the enormous gains in sensitivity, survey speed, and resolution of these telescopes – combined with recent breakthroughs that correct for phased-arrays and the Earth’s distorting ionosphere – we can now take the next big step in this field. Cosmic web filaments and galaxy clusters are the Universe’s largest structures. Clusters grow by a sequence of mergers, generating shock waves and turbulence which heat the cluster plasma. In merging clusters, cosmic rays are accelerated to extreme energies, producing Mpc-size diffuse synchrotron emitting sources. However, these acceleration processes are still poorly understood. Clusters are also heated by AGN feedback from radio galaxies, but the total energy input by feedback and its evolution over cosmic time are unknown. We will construct the largest low-frequency sample of galaxy clusters to (1) establish how particles are accelerated in cluster plasmas, (2) quantify how the cosmic ray content scales with cluster mass, (3) determine the importance of AGN fossil plasma in the acceleration processes, (4) characterize current and past episodes of AGN feedback, and (5) determine the evolution of feedback up to the epoch of cluster formation (z=1-2). These results will be essential to understand cluster formation and its associated energy budget. As in clusters, cosmic web accretion shocks should also accelerate particles producing radio emission. Based on the deepest low-frequency images ever produced, we will (5) carry out the first studies of these giant accelerators, opening up a new window on the elusive warm-hot intergalactic medium, where many of the cosmic baryons reside. Even more important, (6) we aim to obtain measurements of the intergalactic magnetic field, providing key constraints on the origin of our Universe’s magnetic fields.

Keywords: galaxy clusters,radio telescopes,particle acceleration,magnetic fields,cosmic plasmas
first of a kind commercial Compact system for the efficient Recovery Of CObalt Designed with novel Integrated LEading technologies (CROCODILE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Innovation actions
Countries involved: Austria,Spain,Italy,Austria,Germany,Spain,Spain,Italy,Spain,Belgium,Norway,Belgium,Finland,Greece,Sweden,Norway,Belgium,Finland,Greece,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Raw materials Innovation actions (H2020-SC5-2017-TwoStage, 2017)
Start date: 2018-06-01
End date: 2022-11-30
Duration (months): 54.0
Total project cost (EUR): 14623772.15
EU funding (EUR): 11625289.01
Participants: 26
Project status: CLOSED

The CROCODILE project will showcase innovative metallurgical systems based on advanced pyro-, hydro-, bio-, iono- and electrometallurgy technologies for the recovery of cobalt and the production of cobalt metal and upstream products from a wide variety of secondary and primary European resources. CROCODILE will demonstrate the synergetic approaches and the integration of the innovative metallurgical systems within existing recovery processes of cobalt from primary and secondary sources at different locations in Europe, to enhance their efficiency, improve their economic and environmental values, and will provide a zero-waste strategy for important waste streams rich in cobalt such as batteries. Additionally, CROCODILE will produce a first of a kind economically and environmentally viable mobile commercial metallurgical system based on advanced hydrometallurgical and electrochemical technologies able to produce cobalt metal from black mass containing cobalt from different sources of waste streams such as spent batteries and catalysts. The new established value chain in this project will bring together for the first time major players who have the potential of supplying 10,000 ton of cobalt annually in the mid-term range from European resources, corresponding to about 65% of the current overall EU industrial demand. Therefore, the project will reduce drastically the very high supply risk of cobalt for Europe, provide SMEs with novel business opportunities, and consolidate the business of large refineries with economically and environmentally friendly technologies and decouple their business from currently unstable supply of feedstocks.

Keywords: cobalt,critical raw material,batteries recycling,bioleaching,solvometallurgy,ionometallurgy,pyrometallurgy,hydrometallurgy,electrochemistry
Integrating the tissue-specificity and chronology of hereditary renal cancer predisposition (ONCOFUM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 1998698.0
EU funding (EUR): 1339814.62
Participants: 2
Project status: SIGNED

Cancer cells undergo profound metabolic changes. However, little is known about whether and how metabolic changes drive cancer. The discovery that mutations of Tricarboxylic Acid (TCA) cycle enzymes in mitochondria predispose to cancer gives evidence that dysregulated metabolism could drive tumorigenesis. Amongst these, mutations in Fumarate Hydratase (FH) cause Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC), characterised by tumours of the skin and uterus, and renal cancer. Patients inherit one mutated copy of FH and loss of the wild-type (wt) allele occurs in tumours. Fumarate accumulation is the defining biochemical feature of these tumours. However, the mechanisms by which FH loss and fumarate accumulation lead to these tumours is unclear. In ONCOFUM, I want to elucidate the mechanisms that underpin tissue-specific tumorigenesis in HLRCC. I hypothesise that HLRCC occurs via a two-step process. Initially, loss of the wt allele in carriers of a FH mutation leads to FH deficiency. However, most of these cells die and only cells in tissues with the appropriate metabolic hardware survive. In the second step, FH loss in permissive tissues leads to phenotypic changes that lead to cancer. To assess this hypothesis, we will generate a mouse model where we inactivate FH in multiple tissues and elucidate the ensuing tissue-specific reprogramming. Then, using cellular models, we will investigate the molecular consequences of FH loss. In parallel, we will perform a comprehensive analysis of HLRCC tumours to find diagnostic and prognostic tools, and new anticancer targets, which will be validated in vitro and in vivo. The experimental framework developed in ONCOFUM will give unparalleled molecular insights into how cancer develops in different tissues in response to loss of FH and will lead to new therapeutic strategies for HLRCC, and, more generally for the many other cancers to which metabolic reprogramming contributes.

Keywords: mitochondria,fumarate,cancer,epigenetics,oncometabolites
Solar energy, 24 hours, year-round. On or off-grid. (Powerbox)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-04-01
End date: 2023-06-30
Duration (months): 39.0
Total project cost (EUR): 2793013.75
EU funding (EUR): 1955109.63
Participants: 1
Project status: SIGNED

The hydrogen-based Solenco Powerbox allows solar or wind power to be privately stored for hours or months, allowing 24 hour, year-round renewable electric power and heat, independent of the power grid. Powerbox allows every home and business to cheaply store their own generated energy, with over 90% conversion efficiency, electric and heat storage. The Solenco Powerbox is a heavily-patented combination of an electrolyzer and a fuel cell in one unit. It transforms electricity into hydrogen, stores it indefinitely, then converts hydrogen back into electricity and/or heat, at minimal loss. Heat comes out as hot water at a rated temperature of 80°C. Unlike battery storage, the Powerbox stores heat as well as electricity. There is no degradation of conversion capacity over time – its working lifetime is over 30 years. Unlike natural gas storage, there is no need to draw on local underground storage capacity. Unlike hydroelectric power storage, there is no need for local mountains or lakes to be available. Unlike chemical storage, there is no hazardous storage, transport or disposal concern. Our method has zero carbon footprint and works anywhere, allowing homes and businesses to be heated and powered with intermittent solar and/or wind storage and even to feed excess power into local city grids as needed. Solenco will be powerful to commercialize, since it has comparable cost to existing inferior solutions, and has the fastest return on investment (<3 years) of any storage solution on the market. Powerbox is targeted at the EU-28 residential renewable energy market of €33.6B (2016), which continues to grow rapidly. Our founder has created hundreds of energy jobs in Europe. Solenco won the Hansa Green Tour Startup Challenge in 2018 and will earn 530,000 Euros in 2019.

Keywords: hydrogen,energy seasonal storage,electricity,heat,off grid
Commercialising an Innovative and Autonomous Analytical Solution Combining On-Line Measurements with Intelligent Cloud Functionalities for Adding Value to Dairy Products. (InSightPro)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-10-01
End date: 2019-05-31
Duration (months): 20.0
Total project cost (EUR): 1195750.0
EU funding (EUR): 837025.0
Participants: 1
Project status: CLOSED

Q-Interline are a R&D intensive SME offering innovative on-line analytical solutions for food, chemical and pharmaceutical industries since 1996. With more than 200 clients and more than 500 apparatus installed the company is a recognised leader in the Nordic market. InSightPro will deliver a novel Fourier Transform Near-Infrared on-line solution with a set of cloud functionalities aimed to enter new international markets and consolidate their position. Through the interactions with our clients and our small-scale pilot studies, we have found a niche of market (i.e. €250m) composed of large companies together with numerous medium size dairy producers and processors which can afford the investment but do not have the trained staff to deal with the calibration, maintenance and measurement issues. The global Dairy Industry (worth €64.bn) has been going through tough times due to the world recession, reduction in milk sales, price, and production fluctuations. The Industry needs to be more resilient to changes over time through implementing a complete modernisation of the production towards Industry 4.0. Dairy companies (i.e. farms and processing plants) must continuously increase their competitiveness by saving costs and adding value to their products to satisfy a demanding consumer. Our solution allows companies across the dairy industry to perform an easy and unattended production optimisation and monitoring with fast (i.e. <1 year post-installation) return of investment (RoI). InSightPro will serve to bring our product to new markets both EU and US while enabling us to understand how our product needs to be improved and adapted to every process line. It will move our product to full commercial readiness for a Europe-wide launch and a market penetration in the US. The project will enable our company continuous success with turnover expectations of €35.4m, an accumulated net profit of over €26.7m and reaching a RoI of 13.59 after 5 years post project completion.

Keywords: on line analysis,dairy,milk,cheese,butter,powder,automation,cloud services,fourier transform near infrared,quality,farms,processors,ft nir,competitiveness,food losses,food waste
Advanced Design of Very High Power Density Piston Engine and Thermal Management Challenges for Aircraft Application (CS2-WP714-DE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France
Call: Alternative Architecture Engine research (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-02-01
End date: 2019-06-30
Duration (months): 41.0
Total project cost (EUR): 2044444.0
EU funding (EUR): 2044444.0
Participants: 2
Project status: CLOSED

Danielson Engineering is an SME based in Magny Cours (France), SRC certified (Société de Recherche sous Contrat), specialising in the design, the optimisation, the manufacturing and experimental development of innovative engines for automotive and aeronautical applications (http://www.danielson-eng.fr/en/). Danielson Engineering has departments such as Design Office, numerical simulation, Prototyping (foundry + machining) and test benches (engine benches, wind tunnel and component bench) which allows us to deal with any comprehensive development program on-site. With our experience over the last 30 years, our expertise in the development of innovative engines, particularly for aeronautical applications, would ensure the success of the Clean Sky 2 Alternative Architecture Engine Research Project. All our departments will work together and in synergy on this program. Our structure incorporates all the necessary services for Danielson Engineering to accomplish the deliveries involved in this RIA. In addition Danielson Engineering has already worked on development programs for diesel engines at very high power density for applications related to motorsport. Our knowledge in this field of high power density diesel engines gives us a significant advantage, because our experience will allow us to adapt technological ‘bricks’ that we have already developed in the framework of diesel engines destined for the aeronautical sector.

Keywords: danielson engineering,dfm europe,engine,aircraft,simulation,cooling package