Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Software Interface for Interactive Ensemble-Based Drug Design (iEBDD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom,United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-07-01
End date: 2018-12-31
Duration (months): 18.0
Total project cost (EUR): 149951.0
EU funding (EUR): 119326.0
Participants: 2
Project status: CLOSED

The ERC project EBDD was funded to bring about a new generation of computer algorithms to implement accurate molecular simulations of biomolecules and their interactions with man-made molecules that are potential new therapeutics. First results from the EBDD project (ERC-StG-2013-336289) indicate the ground-breaking potential of the academic software generated for supporting pre-clinical drug discovery R&D in the pharmaceutical and biotech sectors. Building on these early results from the EBDD project, this proposal aims to prototype an innovative interactive human-computer drug design workflow that will enhance the value of the academic software, and enable new types of R&D processes (hit discovery, hit-to-lead and lead-optimisation) in a preclinical drug discovery environment. To be commercially viable the prototype must be equipped with an intuitive and robust graphical user interface to enable high quality 3D data visualisation, and that also enable real-time user interactions with large-scale computer simulations executed on remote high-performance computing resources. The computer simulation protocols need to be standardised for ease of use by non-experts, and validated for robustness on industry benchmarks. The prototype will developed in partnership with a professional software SME specialised in interactive scientific data visualization, and a large EU biopharmaceutical company that will test multiple versions of the prototype and feedback on improvements over current processes. This close collaboration with the software SME and pharmaceutical companies will ensure that the resulting prototype will be of high value, meets industry standards, and is ready for commercialisation.

Keywords: molecular simulations,computer aided drug design,pre clinical drug discovery,user interface,software
Nanostructured Yarn Composites for Structural Energy Storage (ENERYARN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

This research is motivated by the ever-increasing need of the aerospace, automotive, and marine industries for novel multifunctional composites with superior structural toughness, capable for energy-storing applications. The proposed topic focuses on the major European societal challenges, such as to reduce weight of transport systems and energy resources consumption, following the European Energy 2020 strategy, Europe 2020 Flagship Initiative, and other climate and energy policies. The project aims to develop the next generation first-of-this-kind large-scale composites reinforced with carbon nanotube yarns, with improved longitudinal and transverse mechanical properties for further integration as electrodes in structural supercapacitors. The Applicant will use carbon nanotube yarns synthesized from natural gas at rates of 10’s km per day by the host laboratory, multiscale engineering principles, and advanced instrumental analysis to maximize CNT alignment and CNT/polymer nanoscale interfacial properties to produce the high-performance laminates which are not feasible with conventional carbon fibres or discrete nanotubes. The project is based on the Applicant’s experience in CNT-based nanostructured composites and advanced spectroscopic nanoscale analysis, and will strengthen her knowledge in direct CNT yarn synthesis and structural composite fabrication according the host group training and excellent infrastructure. A set of new soft skills as an integrated part of this application, will complement her strong technical background and will open a new avenue for future career development in either academia or industry.

Keywords: carbon nanotube yarns,composites,toughness,supercapacitors
consumer grade Ambient assisted living Product family for OLder adult based on indoor LOcation technologies (APOLLO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: France
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 79593.75
EU funding (EUR): 79593.75
Participants: 1
Project status: CLOSED

The goal of this project is to allow the recruitment of a very qualified specialist, as innovation associate of Nively, who holds a PhD (or alternative degree) in disciplines related to design of software interfaces (ideally with experience in design of experience for products targeted to old people) or technologies for Ambient Assisted Living. The associate will lead the analysis, and design of a highly innovative product to maximise safety of old people targeted to the home (B2C) market, through re-design of an existing product, called MentorAge, currently engineered for the B2B market. The product will have to be designed based on sound market and usability analysis. The project will allow opening up significant opportunities for Nively through the creation of a brand-new “consumer business unit” targeting the very vast “silver economy” market. The project will also yield a significant opportunity to the associate, who will be then offered to manage the new business unit after the end of the project.

Keywords: elderly safety,smart environment,ambient assisted living
Image-based analysis for drug discovery and repurposing (REMATCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-08-01
End date: 2020-01-31
Duration (months): 18.0
Total project cost (EUR): 149500.0
EU funding (EUR): 149500.0
Participants: 1
Project status: CLOSED

Drug discovery and development has become a lengthy and resource-intensive process which is characterized by high attrition rates of candidate molecules. Candidate molecules are often identified in high-throughput screening experiments that capture only a small fraction of its biological activities and too many candidates fail in clinical development due to unwanted side-effects and lack of a therapeutic window. In addition, many approved drugs harbor unrecognized therapeutic efficacy in other indications that were not covered during development. Necessary deep characterization of candidate molecules during pre-clinical development demands further efficient and cost-effective methods and data rich assays. Providing a solution to compare phenotypic measurements to a reference database can facilitate the profiling of unwanted effects and the identification of drugs with potential for repurposing. High-content imaging provides a cost-effective solution to capture a broad range of biological responses, however, analysis of such data requires extensive expertise and data processing pipelines. This project has the following objectives: (i) to develop a cloud-based infrastructure for analyses of image-based drug screening (WP1), (ii) to perform a proof-of-concept screen to create a reference database and a showcase for commercialization (WP2), (iii) to conduct market analyses and development of a business plan for a spin-off company (WP3). The ERC Proof of Concept Grant will thus enable us, based on methods pioneered in our ERC Advanced Grant, to develop and perform a proof-of-concept as well as to develop an innovative knowledge base and cloud-IT product for drug development and repositioning.

Keywords: microscopy based high content screening,genomics,image analysis,small molecule screening,drug repositioning,computational drug discovery
AeronautiCal Cyber INtrusion dEtection mechanism (vACCINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Sweden,United Kingdom,Portugal
Call: Machine learning to detect Cyber intrusion and anomalies (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2022-05-31
Duration (months): 32.0
Total project cost (EUR): 695791.25
EU funding (EUR): 499719.51
Participants: 3
Project status: CLOSED

ATC use of datalink is widely expanding over the years. Data communications are a key enabler sustaining SESAR/NextGen services, deployment being planned in the 2020+. Legacy data transmission is not encrypted for existing datalink capabilities and protocol. As a consequence, it is very hard to identify if failure is a malfunction or an attack. However, civil aviation is an increasingly attractive target for cyber-attacks. New technologies such as e-enabled aircraft and modern CNS/ATM systems, together with trends towards greater connectivity, reliance on technology, common infrastructure underpinned with common technologies with common standards, etc. … are changing the risk landscape of the aviation system. The consequences of a potential cyber-attack in civil aviation are wide and can include: (i) Lost of trust in new systems & concepts, limiting their successful deployment; (ii) A 'domino effect' of failures across connected systems or common components; (iii) Closure of the air traffic management system for unpredictable periods; … Since there is not a 'silver bullet' technology that will secure the aeronautical domain, it is essential to: (i) Investigate measures to make the current systems more resilient against cyber-threats (ii) To establish effective and automated solutions for intrusion detection; (iii) Promote its implementation worldwide and build trust across stakeholders. Considering aforementioned challenges, the vACCINE Project aims to design an aircraft onboard security filter with an accuracy level of intrusion detection compatible with cyber protection objectives. The objective is to check/control data from the ground domain before authorizing them to enter the avionics domain not to compromise this level of safety. Based modern digital transformation concepts and cyber-security technologies, the Project will deploy an innovative approach to catalyse the resilient of existing aeronautical communication systems against cyber-threat.

Keywords: cyber intrusion,machine learning,artificial intelligence,security filter,avionics
Turning non-recyclable aluminum waste into metal foams with multiple applications (ALFOAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Aluminum is becoming even more important raw material used in various industries and applications (e.g. lightweight electric vehicles). Over 50% of it produced out of collected waste such as aluminium scrap saving natural resources (bauxites) and energy. Since it requires only 5% of the energy required to produce the primary aluminum. Unfortunately, there is still large amount of aluminum waste (app 5.343 million tons p.a.) going to landfill each year which is neither cost efficient nor neutral to our environment. Createc developed a breaking technology in the form of a recycling process which allows to bring the non-recyclable aluminum waste back into the market thus closing the production cycle. We show how to produce an aluminum foam to make aluminum foam panels. The panels are in the interest of vehicle parts manufacturers, designers, and architects. The foam panels are perfect as energy or noise absorbers and at the same time lightweight with an attractive look. Our technology is environmentally friendly, meaning that we eliminate any chemicals in the production process and we use only 1% of the energy required to produce the primary aluminum. Our panels will be offered in B2B model as two product types: 1) the standard of- the-shelf panels for e.g. architects available at retail shops, 2) as highly customized and specialized products for the hi-tech industry (automotive, aerospace). The aluminum foam market is quickly growing at 7% CAGR and is worth at least €200M in the automotive and decorative markets. The market demand for our foams has been initially confirmed with big manufacturers of car parts, potential customers for energy/noise absorbing panels and architects. Within the Phase 1 project we aim at extending our knowledge of the business environment in our target markets, identify and seek for additional suppliers and customers, and evaluate viability of constructing our first production line.

Keywords: circular economy,non recyclable,aluminium,recycling,waste management,metal foam,energy efficiency resource
Electro-mechanical magnetic blade pitch control (ROTATOR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Netherlands,United Kingdom,United Kingdom
Call: Advanced Pitch Control Mechanism TRL4 Demonstration (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-06-01
End date: 2024-01-31
Duration (months): 44.0
Total project cost (EUR): 4043771.25
EU funding (EUR): 3455024.0
Participants: 4
Project status: SIGNED

Advanced electro-mechanical magnetic pitch control mechanism (PCM) for open-rotor architectures. Open-rotor engines offer an alternative configuration in which the bypass duct is omitted, allowing for significantly higher bypass ratios without incurring the weight and drag penalty associated with a nacelle. It also offers significant CO2 reductions, and for an industry producing over 600 million tonnes of CO2 yearly, adopting this engine could save 180 million tonnes/year. The engine requires accurate control of the blade pitch via an actuation system, and it is this area of control that requires the greatest attention in order to realise the potential fuel savings. Current hydraulic systems transfer fluid to the rotating actuator components in order to control the blade pitch, requiring high-maintenance dynamic seals with potential for leakages. The key areas of innovation in this project centre around the development of a fault tolerant electro-mechanical pitch control mechanism utilizing an ultra-high torque density magnetically geared motor. The system is designed to be fault tolerant from the rotating power transfer device through to the motor torque production, with the development of a lightweight rotating fault tolerant high frequency transformer, fault tolerant electrical drive and fault tolerant motor architecture. Innovative light-weighting technology to form structural parts of the motor and actuator system will deliver a step-change in motor/actuator weight-saving. Development of multi-physical digital twins at the concept stage and then to predict failure rates of the various components. A full-size PCM will be built and tested and a number of components and sub-assemblies of the actuator will be vibration tested at representative temperatures. The coordinated research activities from four highly experienced partners from industry and academia will take the technology to TRL4.

Keywords: actuator,fault tolerant,magnetic gear,electro mechanical,pitch control,lightweight,composites
SHared automation Operating models for Worldwide adoption (SHOW)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Italy,Austria,Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Italy,Germany,Austria,Germany,Germany,Austria,Germany,Spain,Italy,Switzerland,Belgium,Belgium,Greece,Greece,Finland,Sweden,Sweden,Finland,Greece,Sweden,Sweden,Switzerland,France,France,France,France,France,France,France,France,France,France,Czechia,Czechia,Netherlands,Denmark,Denmark
Call: Developing and testing shared, connected and cooperative automated vehicle fleets in urban areas for the mobility of all (H2020-DT-ART-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 36328243.11
EU funding (EUR): 29968148.57
Participants: 90
Project status: SIGNED

SHOW aims to support the migration path towards affective and persuasive sustainable urban transport, through technical solutions, business models and priority scenarios for impact assessment, by deploying shared, connected, cooperative, electrified fleets of autonomous vehicles in coordinated Public Transport (PT), Demand Responsive Transport (DRT), Mobility as a Service (MaaS) and Logistics as a Service (LaaS) operational chains in real-life urban demonstrations in 5 Mega, 6 Satellite and 3 Follower Pilots taking place in 20 cities across Europe. By deploying a fleet of 74 L4/L5 AVs of all types (buses, shuttles, pods, robo-taxis, automated cars connected with MaaS and cargo vehicles) and for all transport operators (passengers, cargo and mixed transport) in both dedicated lanes and mixed traffic, connected to a wide range of supporting infrastructure (5G, G5, IoT, etc.) and operating under traffic speeds ranging from 18 to over 50km/h, it aims to satisfy 7 UCs families and 22 single UCs; that together cover all urban automated mobility needs and wants of the stakeholders (i.e. as reported within SPACE initiative and in ERTRAC roadmap). Project pilots will last for 24 months, with real service seamless operation in each pilot site lasting at least 12 months and will transport with AV fleets over 1,500,000 passengers and 350,000 units of goods. Being the bigger and more holistic ever real life CCAV urban demonstration initiative, it is user led (by UITP) and realised by a Consortium of 77 Partners, 13 third parties, [terminating 9 partners and 6 third parties] and with the additional support of 60 stakeholders (connected through LoS, including major stakeholder Associations) and twinning actions with 11 organisations the US, S. Korea, Australia, China, Taiwan and Singapore.

Keywords: automated road transport,shared mobility,electric vehicles,equity,inclusiveness,connected and cooperative systems,accessibility,maas,laas,public transport,cities,citizens,demonstrations
Hematopoietic stem cell Apoptosis in bone marrow failure and MyeloDysplastic Syndromes: Friend or foe? (ApoptoMDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 1372525.0
EU funding (EUR): 1372525.0
Participants: 1
Project status: CLOSED

Deregulated apoptotic signaling in hematopoietic stem and progenitor cells (HSPCs) strongly contributes to the pathogenesis and phenotypes of congenital bone marrow failure and myelodysplastic syndromes (MDS) and their progression to acute myeloid leukemia (AML). HSPCs are highly susceptible to apoptosis during bone marrow failure and early MDS, but AML evolution selects for apoptosis resistance. Little is known about the main apoptotic players and their regulators. ApoptoMDS will investigate the impact of apoptotic deregulation for pathogenesis, correlate apoptotic susceptibility with the kinetics of disease progression and characterize the mechanism by which apoptotic susceptibility turns into resistance. ApoptoMDS will draw on a large collection of patient-derived samples and genetically engineered mouse models to investigate disease progression in serially transplanted and xenotransplanted mice. How activated DNA damage checkpoint signaling contributes to syndrome phenotypes and HSPC hypersusceptibility to apoptosis will be assessed. Checkpoint activation confers a competitive disadvantage, and HSPCs undergoing malignant transformation are under high selective pressure to inactivate it. Checkpoint abrogation mitigates the hematological phenotype, but increases the risk of AML evolution. ApoptoMDS aims to analyze if inhibiting apoptosis in HSPCs from bone marrow failure and early-stage MDS can overcome the dilemma of checkpoint abrogation. Whether inhibiting apoptosis is sufficient to improve HSPC function will be tested on several levels and validated in patient-derived samples. How inhibiting apoptosis in the presence of functional checkpoint signaling influences malignant transformation kinetics will be assessed. If, as hypothesized, inhibiting apoptosis both mitigates hematological symptoms and delays AML evolution, ApoptoMDS will pave the way for novel therapeutic approaches to expand the less severe symptomatic period for patients with these syndromes.

Keywords: bcl2,bone marrow failure,myelodysplastic syndrome,malignant transformation,dna damage checkpoint