Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS (LIVERHOPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Italy,Italy,Italy,Italy,Belgium,Switzerland,France,France,Netherlands,United Kingdom
Call: New therapies for chronic diseases (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2023-02-28
Duration (months): 74.0
Total project cost (EUR): 5998800.0
EU funding (EUR): 5998800.0
Participants: 24
Project status: SIGNED

Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies that target the pathobiology of cirrhosis. The objective of LIVERHOPE project is to evaluate a novel therapeutic strategy for patients with cirrhosis based on a combination of rifaximin and simvastatin, targeting the main pathophysiological mechanisms of disease progression , namely the impairment in the gut-liver axis and the persistent hepatic and systemic inflammatory response. This dual therapeutic approach is supported by preclinical data showing excellent and very promising results. We will perform two randomized double-blind trials to investigate safety, tolerability and efficacy of combination of simvastatin plus rifaximin in patients with decompensated cirrhosis in 5 EU countries (285 patients will be enrolled in two trials in DE, ES, FR, IT, UK). The expected impact is to halt progression to acute-on-chronic liver failure, the main cause of death, to decrease complications of the disease, to reduce hospital readmissions, to improve cost-effectiveness of therapy. Our final aim is to improve patients quality-of-life and increase survival as patients‘ care is the core of LIVERHOPE. Within the project we will also investigate biomarkers of response to treatment and disease progression that can be useful in clinical practice for improving the treatment of patients. We will invest our effort also in communication and dissemination activities for increasing awareness about chronic liver diseases in European countries so that preventive measures can be established to decrease the burden of cirrhosis and reduce social stigmatization of patients with chronic liver diseases.

Keywords: liver cirrhosis,decompensated cirrhosis,rifaximin,simvastatin,novel therapeutic strategy,main pathophysiological mechanisms of disease progression in cirrhosis
Adaptable and adaptive RES envelope solutions to maximise energy harvesting and optimize EU building and district load matching (EnergyMatching)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Innovation actions
Countries involved: Italy,Italy,Spain,Germany,Spain,Italy,Italy,Italy,Sweden,Sweden,Sweden,France,France,France,Netherlands
Call: Integration of energy harvesting at building and district level (H2020-EEB-2017, 2017)
Start date: 2017-10-01
End date: 2022-07-31
Duration (months): 58.0
Total project cost (EUR): 6926301.34
EU funding (EUR): 5389941.88
Participants: 17
Project status: CLOSED

EnergyMatching aims at developing adaptive and adaptable envelope and building solutions for maximizing RES (Renewable Energy Sources) harvesting: versatile click&go substructure for different cladding systems (R3), solar window package (R4), modular appealing BIPV envelope solutions (R5), RES harvesting package to heat and ventilate (R6). Such solutions are integrated into energy efficient building concepts for self-consumers connected in a local area energy network (energyLAN). The energyLAN is designed to fullfil comprehensive economic rationales (organised by geo-cluster), including balancing cost and performance targets, through the energy harvesting business enhancer platform (R1), which handles different stakeholders benefits, risks and overall cash flows, and it will be exploited to develop specific business models. Operational strategies of the energyLAN are driven by the building and districrt energy harvesting management system (R7). EnergyMatching focuses on residential buildings to open up the highest potential in terms of NZEB target and optimisation of building integrated RES in the 4 seasons. EnergyMatching buildings are active elements of the energy network and as energy partners they consume, produce, store and supply energy and as self-consumers they transform the EU energy market from centralised, fossil-fuel based national systems to a decentralised, renewable, interconnected and adaptive system. EnergyMatching optimisation tool (R2) enables the best matching between local RES-based energy production and building load profiles, and simplifies the energy demand management for the energy distributors. EnergyMatching addresses positive public perception of RES integration, by developing active envelope solution with high aesthetical value and flexibility to cope with different architectural concepts. The proposed solar active skin technologies are easily connectable at mechanical (R3), building energy system (R4-R6) and energy network level (R7).

Keywords: bipv,active and adaptive skin technologies,building and district energy harvesting economic rational,optimization tool,solar windows,res based ventilation and heating,district energy hub
Maritime and Marine Technologies for a New ERA (MarTERA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: ERA-NET Cofund
Partnership: MarTERA (ERA-NET)
Countries involved: Germany,Spain,Italy,Argentina,South Africa,Ireland,Germany,Malta,Norway,Belgium,Poland,Türkiye,Romania,Belarus,France,France,Netherlands,Portugal
Call: ERA-NET Cofund on marine technologies (H2020-BG-2016-1, 2016)
Start date: 2016-12-01
End date: 2022-11-30
Duration (months): 72.0
Total project cost (EUR): 26002703.0
EU funding (EUR): 8580891.99
Participants: 23
Project status: SIGNED

The overall goal of the proposed Cofund is to strengthen the European Research Area (ERA) in maritime and marine technologies and Blue Growth. The realisation of a European research and innovation agenda needs a broad and systematic cooperation in all areas of waterborne transport, offshore activity, marine resources, maritime security, biotechnologies, desalination, offshore oil & gas, fisheries, aquaculture etc. covering all relevant maritime and marine sectors and regions for a sustainable development of the maritime sector. Research and innovation activities in these fields cannot be tackled either at national levels alone, or solely by a single sector. Coordinated actions are required for the maritime industry to strengthen Europe’s position in this important and complex economic field in a global market. The proposing consortium will organise and co-fund, together with the EU, a joint call for trans-national research projects on different thematic areas of Blue Growth. Furthermore, additional joint activities that go beyond this co-funded call are planned, in order to contribute to the national priorities as well as to the Strategic Research Agenda of JPI Oceans and WATERBORNE. With the cooperation of ERA-NET MARTEC and JPI Oceans, a broader variety of topics with a larger amount of funding will be available for the trans-national projects. Moreover, the focus of development in MarTERA is given to technologies (instead of sectors) due to their potentially large impact to a wide range of application fields. The proposal responds to the topic ERA-NET Cofund on marine technologies of the work programme 2016-2017 of the societal challenge 2 (Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bio-economy) under Horizon 2020. Thereby it also contributes to the overall EU objective of building the ERA through enhanced cooperation and coordination of national research programmes.

Keywords: maritime technologies,mechanical and materials engineering
Neuron/mast cell interactions in skin diseases (NEMESIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Atopic dermatitis (AD) is a chronic skin inflammatory disease affecting 10-20% of children worldwide. The etiology of AD is incompletely understood, but many elements (e.g., genetic, environmental or immune) are thought to contribute to the pathogenesis. The skin is specifically enriched in mast cells (MCs) and innervated by a network of abundant sensory neurons. New findings suggest that nociceptive sensory neurons (nociceptors) might regulate the development of immune responses. Skin MCs also express a transcriptional signature of genes encoding neuropeptide receptors (e.g., Mrgprb2: the receptor for the substance P [SP]), through which MCs might uniquely interact with nociceptors. Based on solid preliminary data, the central hypothesis of this project is that SP-producing nociceptor/Mrgprb2+ MC interactions play a critical role in AD pathogenesis. Using a relevant mouse model of AD and innovative imaging approaches, we now aim to elucidate [1] which subset(s) of nociceptor is involved in AD, [2] how SP+ nociceptor/Mrgprb2+ MC interact in our model and in skin lesions from patients diagnosed with AD and [3] how such interactions might favor skin barrier dysfunction. This project promises to provide new insights into skin neuro-immune interactions and may lead to the discovery of new therapeutic targets to treat AD pathology.

Keywords: neuroimmunology,nociceptors,mast cells,skin barrier,atopic dermatitis,allergic disorders
Multiband miniature antenna for Open Hardware IoT Platforms (VARIANT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global Internet of Things (IoT) market is expected to grow 900% by 2025. This will encourage new companies to enter the market. Especially innovative start-ups, whose business model depends on the rapid market introduction of new IoT products, while they cannot assume the complexity and costs associated with the deployment of an IoT project. This is leading companies to consider open source platforms to develop their IoT products. This open source hardware allows them freedom of use, study, modification and distribution and redistribution. In addition, they are scalable for industrial use, portable and low-cost, guarantee security and privacy, and the revolution defined by open source software will similarly increase demand. A large part of any IoT device is Internet connectivity. This requires highly reliable wireless connectivity in moderate conditions that meets the stringent requirements of open source hardware cards. Fractus Antennas (NN) is a Spanish company of passionate entrepreneurs that designs, manufactures and markets miniature antennas for IoT, mobile connectivity and short-range wireless devices. Its team is a pioneer in the development of internal antennas for mobile phones and related handheld wireless devices. The innovative and disruptive solution devised by NN for the growing demand described above is Variant™, the first miniature multiband antenna designed to be used on open hardware IoT platforms. The features that Variant™ can boast are:1) its small size (10 times smaller antenna element than conventional antennas providing the same connectivity);2) the broad spectrum it covers (multiband operation) useful for 4G, 5G, Bluetooth, WiFi, GPS, ISM, etc.;3) easy configuration thanks to the matching network which makes it easy to use in any device and any band without the need of designing a new antenna for each case;4) off-the-shelf so it is ready to be delivered ‘as is’ with no need for customization and 5) no manual assembly is needed.

Keywords: antennas,internet of things,open hardware platforms,multiband,miniature
Market maturation of the first on-board autonomous biofouling cleaning system to keep ship’s hull clean at all times (HCR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Denmark
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-04-01
End date: 2022-09-30
Duration (months): 54.0
Total project cost (EUR): 2086600.0
EU funding (EUR): 1460620.0
Participants: 1
Project status: CLOSED

The world fleet spends €74 billion/ year in fuel, corresponding to 325 million tonnes of fuel and the emission of 1,099 million tonnes of CO2. If nothing is done shipping emissions will increase between 50% and 250% by 2050. It has been estimated that 10% of the vessels energy cost and emissions are due to fouling on the hull. Thus, if the entire world fleet were kept clean of fouling, the savings would be of 32.5 million tonnes of fuel/ year. So far, this is not possible because cleaning solutions are based on expensive dry-dock and call-on-demand underwater services contracted to clean the ship in ports. These solutions have often poor quality, are expensive, unsafe for the divers and/ or maritime traffic and only provide a transient increase in the hull performance. Cliin has developed the first on-board automatic cleaning robot – HCR – that enables a completely new procedure for ship-owners, operators and charterers’ management of the hull. HCR will be permanently installed on the ship and available at any given time and location, allowing a continuous cleaning, thus preventing early formation of fouling. HCR will allow savings in fuel consumption of up to 10%/ year over 5 years when compared to call on-demand solutions. Moreover, the use of HCR improves sustainability of maritime sector by reducing GHG emissions, minimizing the transport of invasive species associated with the fouling and improving the health and safety at the workplace, as there is minimum crew involvement in the cleaning operation and the marine traffic in ports is not disturbed. Through the successful development and implementation of HCR technology, Cliin will be in a strong position to exploit a market projected to value US$ 4 Billion by 2020 and enhance its profitability by the stream of the sales, with an expected cumulated revenue of €107 million, 5 years after project completion.

Keywords: ship hull management,automatic unmanned vehicle,prevent fouling,increase fuel efficiency,reduce ghg emissions
Programming in vitro evolution using molecular fitness functions (ProFF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-11-30
Duration (months): 63.0
Total project cost (EUR): 2141379.0
EU funding (EUR): 2141379.0
Participants: 1
Project status: CLOSED

Natural enzymes are awesome catalysts, in terms of their catalytic efficiency, selectivity, control mechanisms, etc. Revamped as laboratory or industrial tools, they have allowed more than a few breakthroughs, such as PCR, next generation sequencing or green chemistry. The next revolution will be brought by a new generation of extensively modified “enzymatic” catalysts working in non-natural environments, possibly build from non-natural chemistries and targeting an unlimited range of non-natural functions. However, their design is still an arduous process; computational design lacks precision while the combinatorial approach, directed evolution, is limited by labor-intensive or ad hoc selection stages. We will remove the selection bottleneck in directed evolution by introducing biochemical computers able to perform this step autonomously. Based on recent developments in DNA-based molecular programming, these molecular scouts will be co-compartmentalized with genetic libraries into billions of individual compartments in micrometric emulsions. At each generation and in each droplet, after expression of the genotype, these molecular programs will autonomously: i- evaluate the phenotypic signature of a candidate, ii- integrate this information into a predefined scoring function and iii- propagate the relevant genetic information according to this score. The programmability of this approach will make directed evolution versatile, faster, and able to address more challenging problems. The evolution dynamics itself become tunable, offering new perspectives on the fitness landscape of biopolymer catalysts. A quantitative in silico model will be built and integrated in a computer-assisted tool for the fast set-up of in vitro experiments and tuning of the various experimental knobs. Overall, we will close a virtuous circle by evolving the molecular tools enabling the programmable selection of the next generation of catalytic tools.

Keywords: directed evolution,molecular programming,droplet microfluidics,dna nanotechnology
Biological auto-detection and termination of heart rhythm disturbances (Bio-ICD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2023-02-28
Duration (months): 72.0
Total project cost (EUR): 1485028.0
EU funding (EUR): 1485028.0
Participants: 1
Project status: CLOSED

Imagine a heart that could no longer suffer from life-threatening rhythm disturbances, and not because of pills or traumatizing electroshocks from an Implantable Cardioverter Defibrillator (ICD) device. Instead, this heart has become able to rapidly detect & terminate these malignant arrhythmias fully on its own, after gene transfer. In order to explore this novel concept of biological auto-detection & termination of arrhythmias, I will investigate how forced expression of particular engineered proteins could i) allow cardiac tissue to become a detector of arrhythmias through rapid sensing of acute physiological changes upon their initiation. And how after detection, ii) this cardiac tissue (now as effector), could terminate the arrhythmia by generating a painless electroshock through these proteins. To this purpose, I will first explore the requirements for such detection & termination by studying arrhythmia initiation and termination in rat models of atrial & ventricular arrhythmias using optical probes and light-gated ion channels. These insights will guide computer-based screening of proteins to identify those properties allowing effective arrhythmia detection & termination. These data will be used for rational engineering of the proteins with the desired properties, followed by their forced expression in cardiac cells and slices to assess anti-arrhythmic potential & safety. Promising proteins will be expressed in whole hearts to study their anti-arrhythmic effects and mechanisms, after which the most effective ones will be studied in awake rats. This unexplored concept of self-resetting an acutely disturbed physiological state by establishing a biological detector-effector system may yield unique insight into arrhythmia management. Hence, this could provide distinctively innovative therapeutic rationales in which a diseased organ begets its own remedy, e.g. a Biologically-Integrated Cardiac Defibrillator (Bio-ICD).

Keywords: cardiac arrhythmias,cardiac electrophysiology,ion channels
Rhythm synchronization between music and spoken language (RHYTHMSYNC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Rhythm perception is important for a wide range of higher cognitive abilities ranging from time perception to predicting the occurrence of future events, from perceiving language to dancing to the beat of the music. Despite considerable amount of research in rhythm in various scientific disciplines, the way the human mind perceives and produces rhythm is not fully understood. While many interdisciplinary studies look at how performance in one cognitive domain compares to performance in another, it has proven difficult to link the mechanisms for rhythm perception across perceptual and cognitive domains directly. This project therefore looks how rhythm in music and spoken language interact by relying on rhythm synchronization: i.e. the phenomenon that our mind tends to automatically synchronize our motor-activity to the rhythm we perceive auditory (e.g. tapping a finger to the beat of music, the gestures that accompany speech, and singing). Because rhythm in spoken language and music is shaped by experience with culture specific music and our native language, in addition to adults, this project also studies young infants from birth through the crucial early stages of vocal and motor development. The studies in this project rely on a combination of acoustic analyses and electrophysiological methods (sEGM) to determine how rhythm in language and music is synchronized, how synchronization unfolds in time and how differences in rhythm in the two domains affect rhythm synchronization. By looking at similarities and differences in the rhythm of spoken language and music, the project attempts to create a blue-print of the shared and domain-specific cognitive mechanisms necessary for rhythm processing. Because we are surrounded by rhythm in our everyday life, the study of rhythm synchronization can thus help us understand how different rhythms interact and how they influence our daily life and our behaviour.

Keywords: rhythm synchronization,music,spoken language,infants,newborn,adults