Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding functional mechanisms leading to the BILU syndrome (DecipherBILU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The BILU syndrome is an autosomal dominant primary immunodeficiency that combines B cells Immunodeficiency, Limb abnormalities and Urogenital malformations. Recently, we discovered the genetic basis of this disorder using whole exome sequencing. The causative mutation affects the protein that is involved in mediating transcriptional responses after activation of nuclear receptors (e.g. sex hormone receptors). Altered signalling via nuclear receptors is likely to impact a wide range of genes implicated in development, homeostasis and metabolism leading to the BILU syndrome. In this proposal, we develop a strategy to characterize the impact of the newly discovered mutation on nuclear receptor signalling. We will use analysis of patients’ primary fibroblasts, induced pluripotent stem (iPS) cells and CRISPR-Cas9 edited cell lines to investigate how the mutation impacts transcriptional responses after hormonal stimulations. This project will give insights in the function of the newly identified protein that is involved in the BILU syndrome and will help to understand its broader role in regulation of gene transcription.
Innovative Tooling, End-Effector Development and Industrialisation for Welding of Thermoplastic Components (TCTOOL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative tooling, end-effector development and industrialisation for welding of thermoplastic components (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2021-10-31
Duration (months): 25.0
Total project cost (EUR): 1101836.63
EU funding (EUR): 1049357.25
Participants: 5
Project status: CLOSED

The next generation of large passenger aircraft will make extensive use of thermoplastic composites which could replace thermoset composites and metals in many areas of aircraft construction. Thermoplastic composites can be lighter in weight even than thermoset composites, but the key advantage is that they can be joined together using welding processes. This has the potential to eliminate many of the hundreds of thousands of fasteners in an aircraft, improving reliability and reducing assembly costs by over 60%. To take full advantage of thermoplastic composites weldability will require the development of innovative new approaches to tooling and automation to eliminate or reduce fixed tooling costs which can account for more than one third of non-recurring costs. This project will develop innovative new end-effectors for jigless assembly of thermoplastic composite fuselage structures and new adaptive tooling for the welding of thermoplastic fuselage skin to stringers and frames. This will allow highly automated assembly of these complex structures with tooling that can be re-configured digitally and re-used. The project will also deliver simulation tools and perform manufacturing simulations to quantify variations in assembly, risk of defects, and optimise the process to achieve cost-effective zero-defects assembly. This €1050k project will be led by TWI a major industrial research organisation with world-leading expertise in composites joining and large equipment design, FADA-CATEC Center for Advanced Aerospace Technologies with expertise in robotic assembly and aerospace technology, London South Bank University – developers of innovative robotic and end-effector solutions, Brunel University – experts in thermoplastic composites welding and AcroFlight – experts in virtual engineering and simulation.

Keywords: thermoplastic composite aircraft robot assembly tooling adaptive simulation digital twin
Unravelling the secrets of Cu-based catalysts for C-H activation (CUBE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Italy,Germany,Norway,Norway
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-05-01
End date: 2026-10-31
Duration (months): 78.0
Total project cost (EUR): 9885989.13
EU funding (EUR): 9885988.0
Participants: 4
Project status: SIGNED

The Holy Grail of selective C-H activation has been vigorously pursued for more than 70 years in all areas of catalysis - homogeneous, heterogeneous and biological - yet with scarce cross-fertilization. CUBE will bridge this gap, by synergistically disclosing the secrets of Cu-containing biological and synthetic catalysts and translating the acquired knowledge into rationally designed new catalysts with unprecedented activity, selectivity and turn-over numbers. CUBE will capitalize on the recent discovery of abundant and experimentally accessible natural enzymes (LPMOs) that activate resilient C-H bonds using a mono-Cu catalytic center, thus providing a biological analogue to synthetic Cu-zeolites. CUBE will also harness the potential of metal-organic frameworks (MOFs), which offer unprecedented (“enzyme-like”) flexibility in catalyst development. C-H activating Cu-containing Zr-MOFs have just been described. CUBE will generate trans-disciplinary insights into Cu-based catalysts to progress beyond the state of the art in C-H activation. To this aim, we will elucidate the key mechanistic features of oxidant activation by O2, as well as N2O and H2O2, and then C-H activation. Emerging design principles from these studies will evolve new catalysts, including engineered enzymes, enzyme-polymer hybrid materials, and MOFs. To enable these efforts, we will develop novel methodologies at the interface of spectroscopy and computational chemistry. The project brings together leading players in complementary fields: design, synthesis and testing of catalysts (UiO), enzymology and protein engineering (NMBU), spectroscopic investigations of heterogeneous catalysts (UoT) and spectroscopic/computational studies of homogeneous and biological catalysts (MPI). Through a work-plan conceived to maximize cross-fertilization within the project team, we will design and develop novel catalysts for tomorrow’s C-H activation chemistry.

Keywords: protein engineering,chemical biology,bioinspired catalysts,c h activation,direct methane conversion,bio catalysis,enzymatic catalysis,pmmo,lpmo,cu zeolites,cu zr metal organic frameworks
Integrated solutions for pre-processing electronic equipment, closing the loop of post-consumer high-grade plastics, and advanced recovery of critical raw materials antimony and graphite (CloseWEEE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Germany,Germany,Germany,Germany,Germany,Belgium,France,Netherlands,Netherlands,United Kingdom
Call: Recycling of raw materials from products and buildings (H2020-WASTE-2014-one-stage, 2014)
Start date: 2014-12-01
End date: 2018-11-30
Duration (months): 48.0
Total project cost (EUR): 5890660.0
EU funding (EUR): 5890660.0
Participants: 13
Project status: CLOSED

The CloseWEEE project integrates three interlinked research and innovation areas for an improved, resource-efficient recycling of polymer materials and critical raw materials from electrical and electronics equipment (EEE): (1) Efficient and effective disassembly of EEE is key for high quality material fractions, separation of materials but also for reuse of components and parts. An information system for dismantlers will be developed, accessing webbased dismantling instructions, to ease the dismantling process, reduce destruction of reusable parts and components and to allow for a deeper dismantling level for better economics of the Recycling process. (2) Developing resource-efficient and innovative solutions for closing the loop of post-consumer high-grade plastics from WEEE, for new EEE through advanced recovery of valuable plastic streams which do not have a recycling system yet, and subsequent replacement of halogenated flame retardants by halogen-free flame retardants in new EEE. (3) Improved recycling of Lithium-ion batteries through increasing the recovery rates of cobalt and researching a recovery technology for the critical raw material graphite from those batteries. These technology innovations in the various stages of the EEE recycling value chain are complemented by research on reusing the recovered polymer fractions in new EEE, defining product design measures in favour of an optimised recycling eco-system, embedding related product design criteria in EU policy measures and global green procurement activities. These activities will support effectively the objectives of the European Innovation Partnership on Raw Materials.

Keywords: mobile ict devices,consumer electronics,recycling,disassembly,polymers,flame retardants,pc abs,ppe ps,lithium ion batteries,antimony,graphite,ecodesign
From heating and cooling strategies to action: how public authorities can strategically plan the decarbonisation of the heating and cooling sector and initiate impactful projects (ActIonHeat)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Spain,Germany,United Kingdom
Call: Supporting public authorities in driving the energy transition (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 1495702.5
EU funding (EUR): 1495702.5
Participants: 7
Project status: SIGNED

Heating and cooling (H&C) accounts for about half of Europe’s total energy needs with 75% still dependent on fossil fuels. Thus, rapid and significant change is needed to reach the EU 2050 goals. Due to the local nature of H&C systems, action has to be taken at local level involving a variety of stakeholders. This has been recognised in recent years and activities have been started like developing best practice policies and open source analysis tools. However, (efficient) H&C planning and project development are still not commonplace in most European municipalities. The objectives of Act!onHeat are to further disseminate and take up the concept and methods for strategic H&C planning, increase its quality and to push the development and implementation of identified measures. To reach these goals Act!onHeat will implement the following activities: (i) identify the success factors of strong and efficient existing H&C plans and develop a workflow for strategic H&C planning and project development based on the existing open source tools Hotmaps and THERMOS, (ii) support at least 120 municipalities in strategic H&C planning and the development of at least 30 pre-feasibility studies for related individual projects with a mix of tailored individual and group support activities, (iii) train stakeholders who can actively contribute to decarbonisation in the use of workflows, processes and tools through a dedicated training programme, and (iv) leverage additional impact with a mix of Europe-wide roadshow events, acceleration dialogues, webinars and further promotional activities. The consortium is perfectly suited for these activities bringing together leading European experts in strategic H&C planning and policy analysis, local governments networking, capacity building and investment support. A remarkable number of letters of support show the interest of the target group as well as the well-established connections between the target group and the consortium members.

Keywords: public authorities,heating and cooling,decarbonisation,strategic heating and cooling plan
System omics to unravel the gut-kidney axis in Chronic Kidney Disease. (STRATEGY-CKD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Italy,Spain,Germany,Belgium,Belgium,Greece,France,France,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-02-01
End date: 2024-07-31
Duration (months): 54.0
Total project cost (EUR): 3363591.24
EU funding (EUR): 3363591.24
Participants: 12
Project status: SIGNED

System omics to unravel the gut-kidney axis in Chronic Kidney Disease: There is a great need for multi-disciplinary and methodologically well trained scientists in order to unravel complex diseases. Chronic kidney disease (CKD), which is more prevalent in women, and its high risk for cardiovascular disease (CVD) with nearly 50% of all deaths in CKD patients caused by CVD, is such a complex disease and its socio-economic burden is extremely high. STRATEGY-CKD will in this context focus on the gut-kidney axis and the role of the intestinal microbiome as important contributor to the genesis and evolution of CVD in CKD and as possible therapeutic target to improve outcome of CKD patients. For this purpose, 10 leading multidisciplinary academic and 3 industrial investigators and their teams will train young researchers in (1) excellent scientific skills, integrating technological skills [in vitro, bacterial and animals molecular and functional studies, state-of-the-art omic (cultur-, microbi, peptid-, prote-, metabolomics) approaches, bioinformatics, systems biology] in clinical/mechanistic knowledge to generate innovative insights triggering the pathogenesis and treatment of CKD related CVD; (2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research; and (3) exposure to both academic and non-academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative therapies and services. STRATEGY-CKD builds on already available advanced technology, models and patient samples, and established collaborations. STRATEGY-CKD links to ongoing European programs among partners of the consortium. STRATEGY-CKD will stimulate the development of young, broadly-trained scientists able to successfully link basic to clinical research in academia as well as in industry unravelling complex diseases such as CVD-CKD.

Keywords: chronic kindey disease,cardiovascular disease,gut kidney axis,omics
Randomness Extractors: Constructions and Applications (EXT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1493750.0
EU funding (EUR): 1493750.0
Participants: 1
Project status: SIGNED

Randomness extractors are central in theoretical computer science and have a huge impact in complexity theory, error correcting codes, and cryptography to name a few. Informally, a randomness extractor is an algorithm that "purifies" the randomness of an imperfect random source by extracting from it a sequence of uniform and independent random bits. The myriad of applications make randomness extractor theory a vibrant and exciting research field with a major impact. Over the last few years, there has been a flurry of progress on deep long-standing open problems in the field and the PI's work played a key role in this development. Several novel ideas were introduced which give hope that other long-standing open problems in the field can be resolved. Moreover, the new techniques raise new and intriguing questions. In this research, we propose to study some of the most important open problems in randomness extractor theory: classic as well as the new challenges that arise. Moreover, we propose to apply results and techniques from randomness extract theory to three carefully chosen problems with a huge impact on their respective fields: (1) derandomization of space-bounded computation; (2) Ramsey graph constructions; and (3) locally decodable codes. Progress on any of these problems would be ground breaking. Despite the significant challenge, we believe that we are in a unique place to pursue these long-standing open problems both within randomness extractors theory and beyond. Indeed, as mentioned, the PI's work on randomness extractors was pivotal to the exciting progress in the field. Moreover, the PI obtained a breakthrough result on Ramsey graphs construction and the first improvement in 25 years on a problem related to derandomization of space-bounded computation. Both results were obtained using machinery from randomness extractor theory.

Keywords: randomness extractors,derandomization,locally decodable codes,complexity theory,explicit constructions
The first lubrication- and coating-free stoppers for Prefillable Syringes (LUBRIGONE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With a global value of €4,663 million in 2017, Prefillable syringes (PFS) for administration of medical injections have seen an increased use in recent years, thanks to their advantages over the combined use of empty syringes and vials, such as their ease of use, accurate dosage (with less overfill), improved safety and reduced risk of contamination However, PFS require lubrication (usually liquid or baked-on silicone) to ensure their functionality, and this lubrication (which is in direct contact with the medical dosage in the PFS throughout its entire shelf life) may affect the pharmaceutical compounds, reducing their efficacy and causing health and safety issues for patients. To solve this problem, we developed LUBRIGONE, a new line of PFS stoppers combining a chemically inert Thermoplastic Elastomer (TPE) and unique sealing profile designs, which eliminates the need for lubrication and/or coating of the stopper and container. In this way, LUBRIGONE enables a completely clean injection system, protecting sensitive injectables from pollution, and protecting users against potential damage, while granting an optimal functionality (maintaining an acceptable break loose force and mean forces in PFS). Our company, Injecto A/S was founded in 2014 with the goal to develop safe medical devices with primary focus on safe PFS syringes and their stoppers, to create safe and long-term stable drug injections. As a result, the LUBRIGONE project, will be a cornerstone for us, as it will enable us to exploit the market opportunity derived from its competitive advantages over current silicone-oil coated rubber stoppers, and the lack of feasible cost-effective alternatives, In this way, it will facilitate our growth and international expansion: our forecasts are to sell 21.4 million units in the first 4 years of commercialization, resulting in €10.7 million accumulated revenues by 2024, and increasing our staff by 250%

Keywords: pfs stoppers,prefilled syringes,oil free,no lubrication,no coating,unique design,chemically inert material,injection moulding
Runway independent automatic launch and landing system for civil UAV based on GroLaS (REALISE GroLaS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Germany
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

mb+Partner have developed and patented a technology to take-off and land UAV using a mobile ground-based landing gear system (GroLaS). The use of GroLaS reduces the weight, fuel consumption and CO2 emission of airborne vehicles by dispensing the need for the undercarriage and increases operational flexibility by beeing independant of existing runway infrastructure. These aspects result in competitive advantages for UAV operators/users (less costs and higher flexibility). The GroLaS technology has recently become a key technology listed in IATA’s Technology Roadmap aimed at describing the means how the aviation sector can meet its environmental goals. It is also included in the European Union research strategy and in Airbus’ vision for future flying. The project REALISE GroLaS (phase 1-3) will focus on the entry of the GroLaS-technology into the high volume market of unmanned aerial vehicles (UAV) in civil applications. As patent holder, an established strong business network and the commitment of industry partners to the GroLaS technology mb+Partner is uniquely positioned to grow with the rapidly developing UAV market currently worth $6,4 billion p.a. and expected to almost double within the next ten years. The ground-based landing gear system has already been demonstrated successfully at small scale. The objective of REALISE GroLaS (phase 1) is to enable mb+Partner to develop a focused business strategy for the identified key market and (phase 2) moving the GroLaS technology from TRL 6 to 9. mb+Partner is aiming thereby to offer/sell the first operationally feasible combined ground-based launch and landing system for airborne vehicles, as yet unseen in the aerospace industry. Upon completion of phase 2 a market-ready mobile launch and landing system for the market segment of Mini UAV (UAV-market share: 12%) and in phase 3 market entry in the segment of Medium UAV (28% share) is envisaged. The offering of product related services will complement the business model.

Keywords: prototype,market ready product,flying without landing gear,civil uav,feasibility study,business plan