Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing the Thermodynamics of Quantum Control (TQC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: CLOSED

Arguably one of the biggest difficulties facing quantum engineers is quantum control. Quantum systems are incredibly sensitive which is one of their greatest assets, but also and their Achilles’ heel. One can leverage the general theory of feedback and measurement-based quantum control to enhance quantum capabilities to a desired functionality, but there is a problem as quantum systems can be perturbed by those very measurements leading to a loss of control. The aim of this proposal is to develop a general and widely applicable thermodynamic framework of measurement-based quantum control which is abbreviated to the Thermodynamics of Quantum Control (TQC). Studying quantum control through the lens of thermodynamics is a novel idea and allows one to utilise the powerful tools developed in quantum thermodynamics. I will unify the stochastic behaviour of quantum measurements and quantum control with the state-of-the-art research in stochastic quantum thermodynamics. We will validate our proposal by developing testable protocols that can be implemented using current quantum technology and will commence designs with an experimental team in the later stages of the project. The timely results will answer fundamental questions regarding the effectiveness, precision, and efficiency of measurement-controlled sensors and engines. The research will be carried out in the perfectly suited 'Thermodynamics and energetics of Quantum Systems' (QuSys) group of Prof. John Goold at Trinity College Dublin.

Keywords: quantum measurement and control,stochastic quantum thermodynamics
From Subatomic to Cosmic Scales: Simulating, Modelling, Analysing Binary Neutron Star Mergers (SMArt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499762.5
EU funding (EUR): 1499762.5
Participants: 1
Project status: SIGNED

What is the nature of matter at supranuclear densities? What is the expansion rate of our Universe? These open questions of nuclear physics and cosmology can be answered with multi-messenger observation of merging binary neutron stars. The window to study these fascinating events has only recently been opened with the upgrades of gravitational-wave observatories and by combining gravitational-wave information with that of powerful telescopes in the electromagnetic spectrum - from infrared, to optical, to gamma-rays. In the near future, we expect numerous multi-messenger observations of compact binary systems. We are currently at a crossroads in which the development of accurate and robust theoretical models is crucial to keeping up with the development of experimental instrumentation. Without noticeable upgrades of our models, future analyses will be biased through modelling uncertainties. The proposed research project will focus on the development of theoretical models to interpret the binary neutron star coalescence and will pave the way for a thorough understanding of the merger process. Novel methods and algorithms that we will implement in our numerical-relativity code will allow us to study previously inaccessible regions of the binary neutron star parameter space with unprecedented accuracy. This accuracy in the determination of the gravitational-wave and electromagnetic emission from binary neutron star mergers is essential for connecting our theoretical computations with observational data. We will push for a publicly available framework for the simultaneous analysis of gravitational-wave and electromagnetic signals from binary neutron star mergers incorporating also nuclear-physics calculations, nuclear-physics experiments, and other astrophysical observations of isolated neutron stars. This framework will enable us to use upcoming detections to determine the neutron star radius and the Hubble constant.

Keywords: ulti messenger astronomy,numerical relativity,neutron stars,hubble constant,supranuclear dense matter
Beyond Maximalism: The Role of Domestic Political Institutions in the Making and Reception of Excessive State Claims (CLAIMAX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Maximalist claims over territory and other goods abound in global politics, yet we lack a basic understanding of what makes a claim maximalist, what factors drive maximalist claims, and how they can be countered. While Russian claims concerning Ukraine’s foreign policy and territorial integrity as well as Chinese claims to the entirety of the South China Sea strike most citizens, analysts, and policymakers as maximalist, the conceptual distinctions between such claims and other, more ordinary claims have not been made in the international relations or law scholarships. Lacking a conceptual basis, we also do not know much about how to study the causes and consequences of maximalist claims. This project is a valuable first step in the direction of analytically rigorous and policy-relevant studies on excessive claims and ways to counter them. The proposed research defines maximalist claims as those that ostensibly go beyond the relevant rules of international law and claims made by other states. It aims to collect original data on all maximalist territorial and maritime claims in the post-World War II period. Bridging comparative politics and international security scholarship, it will formulate and test hypotheses linking domestic political institutions with the making and reception of maximalist claims. Moreover, it will seek to adduce experimental evidence to the mechanisms underlying perceptions of maximalism and formulation of appropriate responses. Throughout, the main objective of the project will be to understand how regime type influences interactions over maximalist claims involving both states and international organizations. This contribution is particularly timely given the rise of authoritarian regimes and authoritarian tendencies even in otherwise established democracies. Supported by robust communication and dissemination activities, these studies will advance the scholarship on multiple fronts and provide valuable input for policymaking processes.

Keywords: international disputes,domestic institutions,foreign policy
Emerging multifactorial complexity at the geminivirus-host interface (GemOmics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1999973.0
EU funding (EUR): 1999973.0
Participants: 1
Project status: SIGNED

Viruses manipulate their host cells to replicate and spread. This manipulation is based on the activity of virus-encoded proteins, limited due to restrictions in genome size imposed by the viral cycle. How the action of these few proteins results in the massive cell reprogramming observed during the infection remains enigmatic. Geminiviruses are plant viruses causing diseases in crops worldwide. Recent results obtained in our lab using the geminivirus Tomato yellow leaf curl virus (TYLCV) indicate that the proteome of this species, so far believed to encompass 6 proteins, is far more complex than anticipated: the TYLCV genome contains additional open reading frames expressed during the infection and giving rise to new proteins, and viral transcripts are spliced and generate new protein variants. Therefore, the number of viral proteins exceeds double that previously accepted. In addition, we have found that this higher complexity is further increased by the association of viral proteins in an intricate network of intra-viral interactions, which enable novel protein localization and function, leading to an expansion of their interactome and functional spaces. Our results imply that, to get a complete overview of the molecular and functional landscape of plant-geminivirus interactions, the strategies traditionally used, based on the analysis of a limited number of viral proteins in isolation, need to be revisited. Here, we propose to apply a combination of genomic, interactomic, and functional approaches to generate a comprehensive map of the virus/host cell intersection with unprecedented resolution. We will perform a comparative analysis of different geminivirus species, and translate these emerging concepts to independently evolved viral families. The conceptual and practical enlargement of the virus/host interface elucidated in this project has the potential to re-shape the theoretical framework and experimental approaches in the study of virus/host interactions.
STRENGHTENING PHYTOSANITARY RESEARCH PROGRAMMING AND COLLABORATION: FROM EUROPEAN TO GLOBAL PHYTOSANITARY RESEARCH COORDINATION (EUPHRESCO III)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: France,Greece,Italy,Lithuania,Norway,Poland,Portugal,Austria,Slovakia,Spain,Sweden,Türkiye,United Kingdom,Australia,Canada,Switzerland,Belgium,United States,Netherlands,Uzbekistan,Denmark,Estonia,Germany,New Zealand
Call: Programme level collaboration between national R&I policy-makers (HORIZON-WIDERA-2023-ERA-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2884500.0
EU funding (EUR): 2884500.0
Participants: 36
Project status: SIGNED

It is not possible to avoid all the challenges to plant health posed by global trade, increasing travel activities and climate change. However, it is possible to optimise strategies to address these challenges with effective cooperation and coordination. The success of the Euphresco self-sustained network as a platform for the coordination of European phytosanitary research has set the ground for discussions on the development of initiative(s) to address the needs of other regions of the world and on global phytosanitary research coordination. The aim of the project is to enhance national and regional phytosanitary research coordination beyond what the Euphresco self-sustained network has achieved and to set the foundations for global phytosanitary research coordination. This will be achieved by building on the foundations developed by the Euphresco self-sustained network and explore fit-for-purpose activities. The objectives of the project are: -To develop a strategic research agenda. The document will guide phytosanitary research programming activities of EU countries and support them to address regional and global challenges through synergies with other regions/continents of the world. -To organize joint calls on common research priorities to support and enhance international collaboration through the commissioning and implementation of research projects. Monitoring of the research projects will ensure that they remain relevant to the needs of the research funders and policy makers and impactful. -To develop and test models for the governance, the structure and the operation of a global network for phytosanitary research coordination. A business plan will be established to guide the development of a global network for phytosanitary research coordination. -To engage with relevant plant health research stakeholders and foster knowledge exchange, engagement in the project activities, co-development, dissemination and adoption of outputs.

Keywords: plant health,global network,strategic research agenda,joint calls
Tailored technologies for the development of next-generation PROTAC molecules (DEGRON) (DEGRON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

PROTACs (Proteolysis-Targeting Chimeras) are a groundbreaking class of novel therapeutics capable of targeting disease-causing proteins previously thought to be undruggable. They work by recruiting E3 ligases to ubiquitinate target proteins, leading to their degradation. However, despite their promise, current PROTAC design is severely limited, relying on only two out of 613 E3 ligases. In addition, PROTAC development remains slow, inefficient and heavily reliant on trial-and-error approaches. The DEGRON project aims to revolutionize PROTAC drug discovery by commercializing key innovations originally developed in our ERC Starting Grant. First, we developed a patented high-throughput screening system to systematically identify the optimal E3 ligase for any given PROTAC target, enabling rational drug design. Second, we established real-time in vivo systems that enable target validation and precise measurement of PROTAC activity, replacing inefficient endpoint assays and reducing animal use and costs by over 70%. These innovations lay the foundation for a scalable drug discovery platform that transforms PROTAC development into a systematic and predictive process. Our commercialization strategy is two-pronged: 1. Provision of DEGRON services: We plan to establish a company offering PROTAC screening and validation assays to both academic and industrial customers. Over time, our goal is to offer the full PROTAC development pipeline as a one-stop-shop. 2. Development of proprietary PROTACs: We are currently advancing our own PROTAC pipeline under an ERC Consolidator Grant, focusing on therapeutics for pancreatic cancer. These preclinical candidates will be integrated and further developed within DEGRON and progressed towards clinical application. This ERC-PoC study will facilitate the establishment of a spin-off company that integrates E3 ligase discovery, PROTAC validation and drug development to set a new standard in targeted protein degradation-based medicine.
Sensing, predicting and exploiting consumer visual attention in fast-paced marketing environments (CONVISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

In the attention economy, consumer attention is considered a finite, diminishing quantity acting as a currency where brands compete to attract and maintain. Attention-Based Marketing is a relevant emerging subdiscipline of Marketing that studies consumer attention to understand and improve (visual) marketing stimuli, marketing effectiveness, and consumer behaviour by uncovering the fundamental interconnections between attention and action. Three main challenges in this area include how to: a) efficiently measure consumer attention in fast-paced environments (e.g., in electronic marketing), b) optimise marketing stimuli for attracting consumer attention and c) democratise consumer attention data (e.g., eye-sensing data/facial expressions) for improving the experience of individual consumers, while respecting their privacy at the same time. In-line with the above-mentioned challenges, the CONVISE project will integrate insights from the Marketing and Computer Vision disciplines to design methods for sensing, predicting, and exploiting consumer visual attention that can be used to optimise marketing effort and enhance consumer well-being, in social media advertising settings. First, it will design video-based sensing technology for extracting reliable, market-relevant consumer visual attention maps, minimising the necessary human sensor (pre)-processing effort. Next, it will design tools for predicting consumer attention maps from the visual advertising content, without using any sensors, to produce objective advertisement evaluation metrics that can be employed during the visual advertising content design phase. Finally, it will experimentally evaluate the developed consumer attention prediction technology from a consumer behaviour standpoint and will develop sensing data de-identification technology, balancing between consumer privacy protection, perceived ad relevance and ad intrusiveness.

Keywords: attention based marketing,consumer visual attention,privacy protection,deep learning
Hyperpolarized NMR made simple (MagSense)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 2451913.75
EU funding (EUR): 2451913.75
Participants: 1
Project status: CLOSED

Nuclear magnetic resonance (NMR) is one of the most powerful analytical techniques currently available, with applications ranging from synthetic chemistry to clinical diagnosis. Despite the progress in developing new systems, applications are often limited by the low sensitivity of NMR. Hyperpolarization techniques have the potential to overcome this limitation and revolutionize the use of compact NMR. However, the state-of-art devices for hyperpolarization are limited by either the need for cryogenic cooling, long setup and polarization times with the risk of experimental failure, costly systems, cumbersome equipment, and a limited range of polarizable molecules. MAGSENSE project significantly simplifies the existing Hyperpolarized NMR paradigm. Our unique approach is to produce spin order in standard hydrogen molecules to act as polarization batteries. The NMR sample with the enhanced target molecules is placed in a standard NMR spectrometer for ultrasensitive analysis. No modifications are required to the customer’s existing NMR instrumentation. MAGSENSE provides significant advantages in signal enhancement and measurement times, enabling the analysis of intermediate steps in the chemical reaction. MAGSENSE will provide many new opportunities for the fields of Synthetic chemistry, Analytical chemistry, and NMR research. It will be a market-creating innovation with Point-of-service applications, such as diagnosis in ICU units. The project will create opportunities for young researchers in the NMR field through our engagement with Universities and Technology institutes. At the same time, interested industry players have shown their support for the project. NVision is backed by leading deep-tech VC funds from the US and Europe and currently employs more than 25 physicists, engineers, and material scientists. Including professionals with more than 10 years of experience in NMR research, technology development, and project management.

Keywords: hyperpolarisation,nuclear magnetic resonance,low field nmr,high field nmr
A hoListic framework in the quality Labelled food supply chain systems' management towards enhanced data Integrity and verAcity, interoperability, traNsparenCy, and tracEability (ALLIANCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Greece,Luxembourg,Belgium,Türkiye,Croatia,France,Spain,Italy,Cyprus,Serbia,United Kingdom,Germany
Call: Innovative solutions to prevent adulteration of food bearing quality labels: focus on organic food and geographical indications (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 4408546.25
EU funding (EUR): 3843571.25
Participants: 27
Project status: SIGNED

ALLIANCE represents a paradigm shift in the Food Supply Chain Systems’ management for the combat against Food Fraud, distinguishing from the traditionally approaches that leverage monolithic digitalized logistic solutions and standalone FSC interoperability protocols. ALLIANCE aims to provide a holistic framework that safeguards data integrity and veracity, enhances traceability and transparency and reinforces interoperability in quality labelled supply chain of organic, PDO, PGI, and GI food, through innovative technology solutions and validated approaches (such as distributed ledger technologies supported by IoT sensing devices, providing extensible anchors to interoperability protocols and use of in-situ portable rapid testing devices to detect adulteration and verify food origin and authenticity) and fosters evidence-based decision making through AI and ML for preventative interventions and actionable planning. The proposed framework will improve social and economic sustainability of quality labelled food supply chains by ensuring quality & authenticity, increasing food safety, while also considering climatic and environmental impacts of food products. The technologies to be employed in this project will be described and demonstrated in detail to reach higher technology readiness levels (TRLs) and enable smooth and rapid adoption by all stakeholders.

Keywords: treceability,authenticity,daata integrity,interoperability,food chain systems,quality label organic,pdo,pgi,gi food