Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding and designing inorganic materials properties based on two- and multicenter bonds (MultiBonds)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

A major challenge for the green transition is our inability to rationally design inorganic materials with tailor-made properties. This project will tackle this inability by transforming our understanding of chemical bonding in inorganic materials. Understandable rules based on chemical bonds have greatly advanced chemistry but are missing for most material properties, severely limiting the rational design of materials. Until recently, quantum chemical bonding analysis of inorganic materials has only been carried out on a small scale, making it impossible to derive such rules using machine learning. In addition, quantum chemical bonding analysis primarily focuses on two-center bonds. However, multicenter bonds play a critical role in material properties: For example, multicenter bonds have been held responsible for the superhardness of boron-containing compounds and the unusual properties of phase-change materials. By significantly going beyond my recent results on two-center bonds predicting materials properties with simple machine-learning models, I propose to overcome these challenges. The overarching objective of MultiBonds is to derive understandable and universal rules based on chemical bonds for inorganic materials properties through large-scale quantum-chemical bonding analysis considering multicenter bonds. We will 1) develop and apply innovative automated quantum-chemical methods to compute, for the first time, multicenter bonding indicators on a large scale. The generated database will then be used for 2) developing novel predictive deep-learning models and 3) intuitive human-understandable rules for materials properties. As initial applications, we will focus on phase-change materials with low thermal conductivities, magnetic and hard materials, since their properties are known to be governed by multicenter bonds, and they have critical applications (e.g., as thermoelectrics and in the green transition of vehicles).

Keywords: chemical bonds,quantum chemistry,materials chemistry,heuristics,chemical rules,machine learning,thermal conductivity,magnetism,hardness,density functional theory,automation,workflows
Addressing Critical Gaps in mpox epidemiology in DRC - The MOVIE and TRACE studies (MOVIE-TRACE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: United Kingdom,Spain,Congo, The Democratic Republic of the
Call: Mobilisation of Emergency funding for Mpox outbreak research response (HORIZON-JU-GH-EDCTP3-2024-Mpox, 2024)
Start date: 2024-10-15
End date: 2026-04-14
Duration (months): 18.0
Total project cost (EUR): 1431182.5
EU funding (EUR): 1430875.0
Participants: 4
Project status: SIGNED

This proposal outlines two linked studies aimed at addressing the public health challenge of Mpox in the Democratic Republic of Congo (DRC). The MOVIE study focuses on understanding the kinetics of viral elimination shedding light on how MPXV interacts with host tissues and immune defences, which is crucial for developing containment strategies and potentially influencing endpoint selection in therapeutic trials. The TRACE study aims to determine secondary attack rates in MPXV outbreaks, assessing host susceptibility within specific populations, offering vital data to target interventions towards vulnerable groups and informing vaccine efforts by contributing to the assessment of vaccine efficacy endpoints.

Keywords: mpox,viral kinetics,secondary attack rate
Circular Manufacturing 5.0: Human-Centred AI-aided Digital Framework for Closed-loop Photovoltaic (PV) products Value Chains (CIRCMAN5.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Greece,Norway,Italy,Spain,Cyprus,Germany,Lithuania,Switzerland,Ireland
Call: Technologies/solutions to support circularity for manufacturing (Made in Europe Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 5997000.0
EU funding (EUR): 5997000.0
Participants: 19
Project status: SIGNED

The EU guidelines for circular production and supply chains require a strategic approach at every stage of the product lifecycle. The shift towards circularity starts with circular design principles, where the linear “take-make-dispose” model is superseded by the one that prioritizes reusability, reparability, and recyclability. CIRCMAN5.0 combines advanced industry 4.0 technologies with human-centric design principles to assess and demonstrate how waste reduction and optimization of raw material can be feasible and profitable while significantly reducing the environmental impact of manufacturing processes. CIRCMAN5.0 delivers a Human-Centred AI-aided Framework for the Photovoltaic (PV) manufacturing industry, entailing: (I) AI-driven modelling and circular-by-design simulation techniques for product design; (II) ML algorithms for dynamic production process reconfiguration; (III) A Cognitive Digital Twin environment supported by AAS models for testing and verification of manufacturing processes for efficient resource utilisation, waste management etc; (III) A Circularity and Life Cycle Assessment (LCA) Framework to help with comprehensive evaluation of the sustainability aspects of products and processes using data/feedback from AI-based process optimisation, forecasting models, energy and emissions metrics etc.; (IV) The Human-in-the-Loop (HitL) Recommendation Engine to provide actionable and explainable recovery strategies for EoL products; (V) The Digital Product/Material Passport (DPP) enabled by Distributed Ledger Technology enabling secure and trustworthy information sharing. The learning resources developed in the project will equip the EU industrial workforce with digital, circular and transversal skills. CIRCMAN5.0 will be tested in four (4) PV manufacturing industries providing different type of products (e.g., perovskites PV, BIPV, BAPV, OPV).

Keywords: circular by design,cognitive digital twin,environmental impact assessment,lca,forecasting models,human in the loop recommendation engine,distributed ledger technology,digital product passport
Decoding and training spared motor neuron activity in children with paralyzed hands (PlayAgain)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

We have recently identified single motor neuron activity in humans with spinal cord injury and stroke resulting in complete loss of hand function. We have then demonstrated that these individuals can control with high levels of precision the spared motor neurons ensemble in real-time, up to four degrees of freedom of the hand. We have now collected pilot data in children (<4 years old) with a completely paralyzed hand and we also found spared electromyographic activity when the children were playing with an instrumented toy. We developed a new stretchable wireless high-density EMG bracelet tailored forearm of children <3 years old, and also developed a new soft-neuroorthosis to control the small hand of the children. In this proof-of-concept project, we aim to develop a minimally invasive neuromotoric interface for children with paralyzed hands after pediatric stroke and or hemispherotomy. We will develop a system to decode the motor intention of the paralyzed children during gaming activities and associate the spared motor neuron discharge times to a wearable neuroorthosis. We have already demonstrated that our innovative neural controlled orthosis can comfortably move the hand of two paralyzed children. By leveraging the spared motor neuron output and the connection with the proposed neurorthosis, we aim to develop a new neurorehabilitation system for children, that is synchrony with the actual intended movement that are still spared after the neural lesions. This bidirectional neural interface will engage and monitor the remaining neural pathways at the cellular level, with the goal of enhancing and transforming the activity of spared motor neurons into highly functional motor capacities. By leveraging these advanced technologies, we aim to open new research and commercial avenues in paediatric neurorehabilitation and also to answer fundamental questions in movement neuroscience related to pediatric stroke or hemispherotomy.
FOIL’ON - developing and producing biodegradable and suitable for compost laminating film called LAM’ON and packaging foil PACK’ON, lowering plastic pollution (FOIL'ON)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Bulgaria
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-05-01
End date: 2024-10-31
Duration (months): 30.0
Total project cost (EUR): 2033576.68
EU funding (EUR): 1207113.0
Participants: 1
Project status: CLOSED

LAM’ON LTD is a start-up that disrupts the printing and packaging market with two highly innovative products - a 100% biodegradable laminating film LAM’ON and a packaging foil PACK’ON made from corn. Both have the full performance capabilities of plastic film but are based on PLA and are therefore compostable. No recycling needed. They are completely compatible with current printing and packing industrial machines for immediate large-scale market entry, and do not require any changes to process or equipment. Our recipe allows us to produce high quality, affordable and durable clear film on standard polymer extruders. During prototyping we established there are no VOC emissions in the production and its life cycle. We achieved a low price by producing them with one step less than the other solutions on the market and thus saving energy and manpower. With a granulating machine we will reuse the waste material from production which complies with the EU’s “Circular Economy Action”.

Keywords: flexible packaging,lowering voc emissions,lowering plastic pollution,compostable foil,biodegradable laminating film,biodegradable packaging,paper and cardboard lamination,corn based plastic foils
Sustainable structural sandwiches and hollow composites parts for automotive, boat and aerospace markets (SUSPENS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: France,Belgium,Finland,Greece,Portugal,Germany
Call: Advanced lightweight materials for energy efficient structures (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 4995848.45
EU funding (EUR): 4995848.45
Participants: 13
Project status: SIGNED

SUSPENS will develop a holistic approach, from bio-sourced and recycled materials to faster and lesser energy demanding processes, to produce sustainable composite structural parts, ensuring their manufacturability from the design conceptualization. This ambition is basically achieved by the R&D of the coupling bio/circular-materials and processes. SUSPENS will develop up to 95% bio-sourced thermoset resins, with formulations allowing fast cured manufacturing processes and properties adapted to high performance lightweight composite applications. To produce the parts, these resins will be combined with sustainable continuous reinforcing fibre such as natural based cellulose fibres, lignin-based CF, recycled CF staple yarn and continuous GF made from recycled GF for producing well engineered sandwich and hollow parts for transport industries. Some of these parts will be functionalised for added value and reduced assembling times. SUSPENS will also develop an innovative approach for sustainable, optimized energy reduced pyrolysis, using waste stream from the carbonization of precursors, reducing environmental impact of carbon fibre production. For the bio-epoxy, a specific solvolysis will be developed to separate the matrix from the fibres. SUSPENS will assess the valorisation of oil and organic components in these two recycling approaches to transform them into by-products. LCA and LCC studies will show that SUSPENS approaches, combining sustainable materials and processes, can reduce the CO2eq emissions at expected levels of about 40-50%. These achievements will be validated by producing three demonstrators with their respective business models: (1) automotive battery pack for electric vehicle, (2) sailing boat hull/deck and (3) aero-structure winglet part. SUSPENS results will pay-back in terms of lesser energy consumption and environmentally friendly products that can be recycled and expects to bring its assets to the market end of 2028.

Keywords: fibre reinforced thermoset composite,bio epoxy,bio polyester,biosourced fibre,carbon fibre,glass fibre,sandwich core structure,hollow structure,polymer,composite recycling
SCALE'HER - Boosting women-led start-ups for growth (SCALE-HER)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Sweden,Bulgaria,Slovakia,Romania,Portugal,Greece,France,Denmark,Ireland
Call: Startup Europe (HORIZON-EIE-2024-CONNECT-01, 2024)
Start date: 2025-07-01
End date: 2027-12-31
Duration (months): 30.0
Total project cost (EUR): 1996875.0
EU funding (EUR): 1996875.0
Participants: 10
Project status: SIGNED

SCALE'HER aims to strenghten women-led start-ups in strategic digital and deep tech markets across Europe. It emphasises growth, leadership development, market validation, and networking to enhance their market footprint and strengthen connections with relevant ecosystems and potential new markets. Prioritising startups with market-product fit or financing, especially from LCIEs, SCALE'HER provides support services for women-led startups. Through innovative cross-border activities like blind audition competitions, and an individually tailored acceleration programme, it fosters connections between startups and ecosystems including matchmaking with investors and business opportunities. The project also includes initiatives such as "Mission innovation" to strenghten the connection within and between the stakeholders and ecosystems in Europe, or the "Women Entrepreneur Roadshow" to showcase startups to investors, expanding their presence in key areas like AI and cybersecurity. Ultimately, SCALE'HER will foster the growth of women-led scale-ups, promote diversity, and advance strategic digital technologies across Europe while creating solid bridges between European innovation ecosystems in Europe.

Keywords: women entrepreneurs,business opportunities,business development,business support services,technology development,innovation procurement and pan european research infrastructures,women in tech
Interdisciplinary and Intersectoral Research Fellowship Program for Future Leaders in Immunology (IMMUFELLOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Finland,United States,Estonia,Italy,Netherlands,Ireland,United Kingdom,Portugal,Sweden,Belgium,Spain,France,Austria,Denmark,Germany,Japan
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 3722400.0
EU funding (EUR): 3722400.0
Participants: 37
Project status: SIGNED

Interdisciplinary and Intersectoral Research Fellowship Program for Future Leaders in Immunology (IMMUFELLOW) is an innovative postdoctoral training initiative of the University of Turku (UTU) and Åbo Akademi University (ÅAU) in Turku, Finland. Immune-related diseases, such as infections, atherosclerosis, and cancer, are increasing in prevalence and pose major societal/economic challenges. IMMUFELLOW will cultivate experts and leaders in immunology who will drive research advancements to address unmet needs in preventing and treating immune-mediated diseases. IMMUFELLOW will build on UTU’s/ÅAU’s excellence in leadership development, advanced education models, and beyond state-of-the-art immunological research ecosystem and infrastructure. With 22 experienced postdoctoral researchers (ERs) recruited for 36-month terms via a rigorous, merit-based selection process, this initiative prioritizes interdisciplinary and intersectoral research, aligning with the European Charter and Code. Supported by the InFLAMES Flagship, IMMUFELLOW fills a critical void in postdoctoral training, offering a structured program integrating science, technology and entrepreneurship. IMMUFELLOW ensures comprehensive research excellence and training opportunities beyond academia, with the following key features: Support and Mentoring: Each ER benefits from a dedicated intersectoral mentoring team, access to exceptional training opportunities, and monthly seminars/networking events. Sector-Wide Involvement: Beyond academia, fellows explore research, training, and development opportunities in corporate settings, with education on regulatory standards/good practices in diagnostics, drug development, and manufacturing. Entrepreneurial Skills: Equipping fellows with the skills and knowledge to thrive in diverse professional environments. IMMUFELLOW thus stands at the forefront of postdoctoral training, fostering the next generation of leaders in immunology and driving impactful research advancements.

Keywords: immunology,health,health economics,interdisciplinary,intersectoral,medicine,ai,imaging,mentoring
Remote SWEATSkin PATCH for Monitoring Breast Cancer Therapeutic Response (SWEATPATCH)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Spain,Italy,Slovenia,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-04-01
End date: 2028-03-31
Duration (months): 48.0
Total project cost (EUR): 2806363.75
EU funding (EUR): 2670933.75
Participants: 11
Project status: SIGNED

Breast Cancer (BC) is the most common cancer in Europe. In most cases, BC will present at a locally advanced or distant stage, which requiresanticancer drugs. However, there is no guarantee that the favorable drug benefit/risk balance will align with expectations at an individual level or be maintained over time. Therefore, monitoring tumor response to treatment is critical for timely adjusting the therapeutic strategy to improve patients’ outcomes. To fulfill this unmet medical need,SWEATPATCH proposesan innovative non- invasive approach to monitor in real-time BC response to treatment, based on emerging odorous biomarkers, namely volatile organic compounds (VOCs) from sweat emanated from the breast skin. Due to their connection to breast tumor metabolism, sweat VOCs are promising candidate biomarkers for monitoring tumor response to treatment.SWEATPATCH breakthrough relies on a radically-new technology with cutting-edge straintronic microwave based on phononic metamaterials and nanomaterials chemtronics technologies to solve scientific bottlenecks for sweat VOCs analysis in the near field of cancer cells.SWEATPATCH will gather an interdisciplinary consortium of leading experts in materials, sensors, data processing, and translational/clinical oncology, from 6 countries. The consortium will develop a groundbreaking wireless Lab-on-a-Patch to (1) monitor BC therapeutic response directly from the breast surface using a novel biocompatible flexible patch combined with specific data analysis that (2) will also be adaptable to in vitro 3D culture systems of patients’ derived organoids, a tumor model avatar created from patients’ BC, which will be used for drug screening to modelize tumor response to treatment.SWEATPATCH will convey a considerable conceptual leap that will shift the current healthcare paradigm from «one-size-fit-all» monitoring to «a smart real-time personalized monitoring»synchronized to tumor biology to reach precision oncology.

Keywords: breast cancer,therapeutic response,lab on a patch,volatile organic compounds,straintronic sensors,magneto electric