Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Solute carrier proteins as the gates managing chemical access to cells (GameofGates)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2389782.0
EU funding (EUR): 2389782.0
Participants: 1
Project status: CLOSED

Chemical exchange between cells and their environment occurs at cellular membranes, the interface where biology meets chemistry. Studying mechanisms of drug resistance, I realized that SoLute Carrier proteins (SLCs), not only represent the major class of small molecule transporters, but that they are encoded by one of the most neglected group of human genes. I identified a case where an SLC controls the activity of mTOR, suggesting that other SLCs may be involved in signalling. This formed the basis for the GameofGates project proposal. The name refers to SLCs as a metaphor for cellular gates coordinating access to resources following game rules that are largely unknown but worth learning, as the acquired knowledge could impact our understanding of cellular physiology and open avenues for innovative treatment of human diseases. GameofGates (GoG) plans the investigation of SLC function by comprehensively and deeply charting the genetic and protein interaction landscape of SLCs in a human cell line, while monitoring fitness, drug sensitivity and metabolic state. GoG aims at functionally de-orphanize many SLCs by assessing hundreds of thousands of genetic interactions as well as thousands protein and drug interactions. I hypothesize that SLC action is linked to signalling pathways and plays an important role in integration of metabolism and cell regulation for successful homeostasis. I propose that whole circuits of SLCs may be linked to particular nutrient auxotrophy states and that knowledge of these dependencies could instruct assessment of vulnerabilities in cancer cells. In turn, these could be pharmacologically exploited using existing or future drugs. Overall, GoG should position enough pieces into functional and regulatory networks in the SLC puzzle game to facilitate future work and motivate the community to embrace investigation of SLCs as conveyers of metabolic and chemical integration of cell biology with physiology and, in a wider scope, ecology.

Keywords: solute carriers,metabolomics,membrane transport,systems biology,drug sensitivity
Reusable precast steel-concrete composite floors (REUSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-05-15
End date: 2021-06-06
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

There is an urgent need for sustainable development in modern societies. The construction sector can play an important role in achieving a sustainable environment, since the production of new materials is an energy-intensive process, which is responsible for about 15% of the global CO2 emissions, and buildings are usually demolished at the end of their useful life producing waste. A more sustainable solution is to develop innovative structural solutions that allow for the reuse of building components directly to new projects. In this way, the construction will produce less CO2 emissions, much less waste will go to landfill, and the natural resources of the planet will be used more responsibly. This project proposes a novel way to connect precast concrete slabs with steel sections that offer the advantages of a) off-site fabrication of all components; b) easy and fast installation on the construction site; c) disassembly of the composite floor; and d) direct reuse of all components in new projects. The project will use experimental testing complemented by numerical analyses to develop the proposed novel structural system. The experiments will provide evidence on the physical behaviour and the ultimate failure modes of the proposed system, whereas numerical simulations using advanced mathematical models will be used to study numerous geometrical configurations and generalise the results of the tests. Based on the results of the tests and the simulations, recommendations for the practical design of the proposed system will be proposed.

Keywords: steel concrete composite beams,demountable structures,reuse of materials,large scale experimental testing
A New proTection devIce for FOD (ANTIFOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,United Kingdom,United Kingdom,United Kingdom
Call: Development of a Foreign Object Debris (FOD) protection device applied to an electrical ECS fresh air inlet. (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2022-01-31
Duration (months): 39.0
Total project cost (EUR): 1437108.75
EU funding (EUR): 1361569.5
Participants: 5
Project status: SIGNED

The main objective of this innovation action is to develop a Foreign Object Debris (FOD) protection device applied to an electrical ECS fresh air inlet, validated to TRL5. This will be achieved through the following two-stage design process, each with their own secondary objectives: 1. Preliminary design, which aims to: a. capture the top level requirements through a survey of the user needs and used to develop a set of baseline candidate concepts. b. use innovative design methods to conduct a concept study. c. verify prototypes rapidly using a combination of CFD and additive manufacturing, as measured by comparing calculated separation efficiency and pressure loss. d. refine the highly ranked concepts via a trade-off study and determine the best suited solution that meets all the top-level requirements, measured through a scoring system. e. produce a preliminary design from the winning concept, including feasibility study, sensitivity analysis, risk assessment, and system requirements report, measured through a preliminary design review (PDR) which demonstrates compliance with the user needs. 2. Detailed design, which aims to: a. define an aerodynamic geometry for the intake protection and FOD separation device which demonstrably meets the relevant requirements and integrates with the mechanical interfaces of the existing intake scoop inlet, scoop ducting and eECS inlets, and is measured through Wall-Modelled LES simulations. b. produce a detailed design and subsequent manufacture of the full-scale intake protection and FOD separation device. c. design a test bench to validate the intake protection and FOD separation device. d. deliver a final full-scale working prototype to the Topic Leader which demonstrably meets the user needs, as measure.

Keywords: intake protector device,fod protector device,eecs turbocompressors
An online data management tool to implement industrial symbiosis projects towards a circular economy (Siner)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The demand for resources (water, food, energy, land and minerals) is continuously increasing, given the rising purchasing power of a growing populatiThe demand for resources (water, food, energy, land and minerals) is continuously increasing, given the rising purchasing power of a growing population. The global resource extraction is projected to reach an estimated value of 184 billion tonnes in 2050 and the supply could be further aggravated by climate change, making natural resources increasingly scarce and more expensive. Hence, industrial symbiosis is the tool to implement circular economy into the manufacturing sector: it’s the process by which waste or by-products of an industry or industrial process become the raw materials for another. Big data analysis is a promising approach to identify the potential industrial symbioses within the perimeter of a large industrialized city. However, industrial symbiosis hasn’t been widely implemented because resource input and waste output data aren’t disclosed or collected, making data-driven and optimisation solutions very difficult to implement. Simbiosy has developed Síner, an industrial symbiosis project management software that manages and estimates resources (raw materials, waste, water and energy) and waste (wastewater, residual heat) data of the industries within a given territory. Síner gathers data from different sources and processes it via Big Data tools and algorithms that are capable to estimate the unavailable data. The aim of the phase 1 project is to improve our understanding of the EU market for industrial symbiosis management tools, identify regional market variations in terms of purchase decision makers, appropriate business models, pricing structure and identify which are the most attractive markets for us to use as a beachhead. In the EU, circular activities generated almost € 147 billion in value added and account for €17.5 billion worth of investments. We plan to target 16,884 municipalities.

Keywords: industrial symbiosis,resource database
ZETAMIX, the first Desktop Ceramic 3D printer on the market (ZETAMIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

NANOE is an SME evolving on the Ceramic Engineering market for 10 years, as a manufacturer of ready-to-sinter and high-purity nanopowders for the industry. NANOE innovated on that market by allowing its clients to use its powders in a standard production process, by resolving difficulties linked to powder’s fineness. With the development of a complete range of ceramic materials and high industrial production capacities, NANOE rapidly succeeded in increasing its turnover. To further increase its development, NANOE diversified its activities on the Additive Manufacturing (AM) market, where the only commercialized Ceramic printers, based on stereolithography and binder-jetting technologies, stay complex to use and costly. Instead of adapting printers to the production of specific raw-materials, NANOE adjusted Ceramics’ binding formulation, so that it can be used on desktop printers already available on the market. ZETAMIX will be the first range of ready-to-use ceramic filaments that can be used with common desktops 3D printers worldwide. Thanks to ZETAMIX, industrials will be able to print quicker high-quality technical ceramics in small series, at any time and for an entry-price of €10 000. NANOE commercialized a first version of its ZETAMIX filaments, which is currently produced at a laboratory-scale and tested within some companies. Thanks to its numerous competitive advantages, its unique approach, its existing network of resellers and the recognition of its brand, NANOE should rapidly expand on the technical materials for AM market. NANOE will first target the markets segments of automotive, aeronautics and energy and rapidly expand on international markets. NANOE still have to solve technical challenges regarding filaments’ facility of use and parts quality. These developments will be financed in the frame of SME instrument Phase 1, with the objective to become the worldwide leader in technical materials’ 3D printing for the industry within the next 5 years.

Keywords: 3 dimensions printing,additive manufacturing,nanopowders,filaments,ceramics,advanced materials,technical ceramics,fused deposition modeling,fused filament fabrication,desktop printer
Direct Temporal Synthesis of Terahertz Light Fields Enabling Novel Computational Imaging (DIRECTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2477947.0
EU funding (EUR): 2477947.0
Participants: 1
Project status: SIGNED

The terahertz (THz) frequency range is widely considered as the most challenging and under-developed frequency range due to the lack of technologies to effectively bridge the transition region between microwaves (below 100 GHz) and optics (above 10,000 GHz). Although THz radiation would be perfect for material identification and as a safe alternative to X-rays for producing high resolution images of the interior of opaque objects, first a fundamentally new approach is needed to establish novel devices and techniques. Rarely considered for its complexity, the so-called “light field” consists of all light rays in 3-D space, flowing through every point and in every direction. Thus a light field camera not only records color and brightness like a 2-D imaging sensor does, but also the direction/angle of all the light rays arriving at the sensor. The beauty of this spatio-directional information is that one can localize hidden objects and calculate their covered three-dimensional shape. So what’s the catch? For any practical means, the natural ambient THz radiation is by far too weak, and THz light-fields need to be created artificially. Here I propose an innovative pathway empowered by massively scaled THz source and detector arrays, which will bring forth the science of computational light-fields to THz 3-D see-through imaging. Starting with newfangled THz source-arrays, I create the missing temporal modulated light-fields directly at the source and investigate a diffraction inclusive THz light-field system theory, architecture and algorithms. This is combined with innovative THz integrated circuits to research real-time THz light-field components. Although the far-reaching objectives incorporate a high risk due to the complexity of the approach connecting physical, computational, and optical sciences with engineering approaches, this is offset by the promise of major breakthroughs to create substantial value for both science and the global economy.

Keywords: terahertz thz technology,electronics,integrated circuits,silicon process,technology,thz camera,thz transmitter,receiver arrays,see through imaging,light field,plenoptics,computational imaging,3 d imaging,mimo
Quantum Dot Fermi-Hubbard Emulators (QuDoFH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 3449720.0
EU funding (EUR): 3449720.0
Participants: 1
Project status: SIGNED

We propose to use semiconductor quantum dot arrays as a well-controlled model system for emulating the Fermi-Hubbard Hamiltonian. In its simplest form, this Hamiltonian contains just two terms, describing hopping of fermions between adjacent sites in a lattice and an interaction energy for two fermions to occupy the same site. Despite its simplicity, this Hamiltonian produces a wealth of many-body physics phenomena, from exotic forms of magnetism to superconductivity. Their intricate quantum correlations make simulation on conventional computers exponentially difficult. This has motivated the use of model systems such as ultra-cold atoms to emulate Fermi-Hubbard physics. The in-situ parameter control, large energy scales compared to temperature and the flexibility of lithography, make gate-defined quantum dot arrays a highly versatile and powerful model system for emulating Fermi-Hubbard physics. This has long remained a distant prospect due to unavoidable disorder and cross-talk, but recent progress in our lab shows that these obstacles can be overcome in small arrays. This allowed us to observe Nagaoka ferromagnetism, a form of magnetism driven by electron-electron interactions that has not been reported in any system so far. In a series of breakthrough advances, we will define and operate extended square and triangular quantum dot ladders, targeting a complexity that cannot be matched by classical computers. We will focus on three phenomena at the heart of quantum many-body physics: 1) resonating-valence bond physics at half-filling, 2) doped Mott insulator physics and 3) quantum phase transitions. Besides measuring current through the system, we will perform single-shot measurements of charge and spin, giving access to multi-point correlation functions and time dependent evolution. These studies will increase our understanding of Fermi-Hubbard physics, with long-term application in materials design and discovery.

Keywords: quantum dots,quantum simulation,fermi hubbard model
Improving drug delivery to the brain and glioblastoma treatment using temperature. (Nano_Brain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Therapeutic drug delivery to the brain remains an unsolved challenge that limits the treatment of neurological and brain diseases, such as Glioblastoma, Parkinson and stroke. The main limitation is in the ability of the therapeutic drugs to cross the Blood Brain Barrier (BBB). To overcome this limitation, scientists present hyperthermia as an approach to overcome this limitation. Although this approach show promising results, the studies were not focused on understanding and combining the temperature raise during the BBB opening. Thus, the possibility of using this temperature rise to both improve the BBB opening performance and to exploit it to treat brain diseases is not used. For the aforementioned to be actualized, this project will bring the latest advances in intracellular temperature and nano-thermometry to a deeper understanding of the role of temperature in the BBB opening and its possible utilization in the treatment of brain diseases, such as glioblastoma. Thus, with the effort of the host organization (world leader in develop of nanomedicine platforms) and the experienced researcher (expert in nano-thermometry), two important objectives will be achieved under this Marie Skłodowska-Curie fellowship: (1) detailed studies and understanding of both the intracellular temperature and extracellular temperature needed for the BBB opening and (2) design and synthesis of the nano-complex for simultaneously BBB opening and the release “in real time and on demand” of therapeutic drugs for glioblastoma treatment in vivo. The outcome of this proposal will represent an important step forward in the field of brain drug delivery, that will not only improve the applications of nanotechnology in glioblastoma treatment, but will also facilitate the overcoming of the actual limitations in the treatment of different brain diseases.

Keywords: blood brain barrier,temperature,nanothermometry,glioblastoma
Compact bio-based thermal energy storage for buildings (ComBioTES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Germany,China,Poland,France,France,Czechia,Netherlands,Denmark,United Kingdom
Call: Research on advanced tools and technological development (H2020-LC-SC3-2019-ES-SCC, 2019)
Start date: 2019-11-01
End date: 2025-04-30
Duration (months): 66.0
Total project cost (EUR): 4193978.75
EU funding (EUR): 3999128.75
Participants: 13
Project status: SIGNED

Thermal end-uses (space heating, hot tap water, cooling) represent a major part of electricity consumption in Europe and cause consumption peaks, often when electricity is expensive. Hot tap water is the only thermal end-use provided as a base load over a year and that is stored. Space heating and air conditioning are seasonal thermal end-uses with a high residential electricity consumption. They are not stored at the buildings scale to allow peak shaving of the residential electricity consumption. These statements show the interest to develop appropriate thermal energy storages, suitable for buildings, to reduce the electricity bill of end-users. ComBioTES will thus develop a modular compact thermal energy storage (TES) solution for heating, hot tap water and cooling fully adapted for electricity load shifting. A first modular TES will be able to store hot tap water to be converted into ice storage during summer (cooling needs). A second compact latent TES, using high performances (ΔH≈260kJ/kg) bio-based non-aggressive PCM, will store high heating energy amount, for space heating or hot tap water demands. As thermal end-uses in buildings are different regarding seasonal needs, this concept combines the advantage of a modular TES (high utilization rate) with the high volumetric energy density of a latent TES using a bio-based PCM (high compactness: ≥ 100kWh/m3 ΔT=50°C). The ComBioTES consortium and associated External Advisory Board (Idex, Danfoss and Passive House) involve all relevant key players in energy storage and management: RTOs for development and testing infrastructure and SMEs for manufacturing & commercialization of the technology, and representative of potential customers and end users (building owners &operators). In line with IC7, two partners from CHINA (The Institute of Electrical Engineering of the Chinese Academy of Sciences, and The Henan Province GuoanHeating Equipment Co., LTD) will promote the ComBioTES concept in this country.

Keywords: compact thermal energy storage,switchable thermal energy storage,power to heat,electricity load shifting,bio based storage materials,non aggressive storage materials,phase change material pcm