Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AVELEDA Fruit Wine (AVELEDA Fruit Wine)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Portugal
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

“AVELEDA Fruit Wine” aims to create an innovative type of Fruit Flavour Wine by fermenting the fruit with the grape’s must, by combining new processing technologies and taking advantage of existing wine high-tech processes. With AVELEDA’s new approach a substantial natural product will be achieved in the Flavoured Alcoholic Beverages category. This will permit AVELEDA to become a superior market reference regarding the delivery of a more competitive product with substantial novelty to the wine industry. This lower % of alcohol wine will be a more natural product, meeting today consumers’ growing concerns with their health. Also it will be achieved an effective industrial process addressed for natural fruit-wine production that can also enable reducing fruit waste generation. Feasibility study will be a major tool to set reasonable goals and strategies and therefore to minimise risks of failure during commercial implementation. This first phase will expand commercial exploitation strategy, develop samples wines to adjust consumer profile and flavour trends, accordingly to chosen markets, and also improve business strategy taking into account consumers’ feedback. Phase I will enable a more consistent business plan and go to Phase II with coherent and realistic business strategies. AVELEDA’s first fruit-flavoured wine will achieve a new wine category of relevant consumers with special concerns: health issues, seeking natural products. Taking into concern the dimension of potential wine consumers for this category there is a growing demand for fruit wines in several European countries but, at the time, there are no substantial values that disclose the exact size of this niche market. By promoting new and healthier wines and processes reusing fruit and significantly reduce its waste generation, European challenges with regard to Sustainable food production and Safe food&healthy diets will be adressed as a way to improve the competitiveness in the wine/food industry.

Keywords: fruit flavour wine,natural product,reduction of wastes,healthy diet,sustainable food production
Clinical translation of a novel CD1a-directed CAR for relapse/refractory cortical T-cell Acute Lymphoblastic Leukemia: feasibility, efficacy and safety (IT4-TALL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Immunotherapy has revolutionized cancer treatment over the last decade. Adoptive cell immunotherapy with T-cells genetically redirected to a tumor-specific antigen using a chimeric antigen receptor (CAR) has achieved impressive response rates in advanced B-cell acute lymphoblastic leukemia (B-ALL). CAR T-cell strategies beyond B-cell tumors are, however, hampered by expected toxicities, owing to the lack of bona fide therapeutic and safe antigens. Indeed, there are no immunotherapeutic therapies (including CAR T-cells) approved for T-cell malignancies (T-ALL or T-cell lymphomas), as the shared expression of target antigens between CAR T-cells and T-blasts induces CAR T-cell fratricide and T-cell aplasia, leading to fatal immunodeficiency. We recently identified the CD1a antigen as a safe target for CD1a+ cortical T-ALL (coT-ALL), a major subgroup of T-ALL, and we have developed a novel CD1a-specific CAR. Results generated from my previous ERC-funded work (INFANTLEUKEMIA nº646903 and IT4-BALL nº811220) have just been protected by a European Patent (EP19382104.8; CARTs for the treatment of CD1a+ cancer). Our intellectual property rights coupled to our internationally-endorsed top-tier scientific publication are a major strength of our proof-of-principle demonstration that CD1a-directed CAR T-cells constitute a unique immunotherapy approach for coT-ALL. We propose to consolidate final technical-biological improvements and GMP-grade manufacturing of our CD1a-directed CAR T-cells in compliance with the requirements of the Spanish Regulatory Agency of Medicines and Medical Devices for advanced adoptive cellular therapies (AEMPS). Data from this project will be added to the final Investigational Medicinal Product Dossier (IMPD) of the CARCD1a T-cells to be submitted to AEMPS for regulatory approval to launch a pan-European open Phase Ib clinical trial for relapse/refractory coT-ALL in early 2022, ensuring social and health value of this innovative immunotherapy.

Keywords: acute leukemia,immunotherapy,car t cells,cd1a,clinical trial
Computational Random Multiscale Problems (RandomMultiScales)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-08-01
End date: 2025-07-31
Duration (months): 60.0
Total project cost (EUR): 1796926.0
EU funding (EUR): 1796926.0
Participants: 1
Project status: SIGNED

Geometrically or statistically heterogeneous microstructures and high physical contrast are the key to astonishing physical phenomena such as invisibility cloaking with metamaterials or the localization of quantum waves in disordered media. Due to the complex experimental observation of such processes, numerical simulation has very high potential for their understanding and control. However, the underlying mathematical models of random partial differential equations are characterized by a complex interplay of effects on many non-separable or even a continuum of characteristic scales. The attempt to resolve them in a direct numerical simulation easily exceeds today's computing resources by multiple orders of magnitude. The simulation of physical phenomena from multiscale models, hence, requires a new generation of computational multiscale methods that accounts for randomness and disorder in a hierarchical and adaptive fashion. This proposal concerns the design and numerical analysis of such methods. The main goals are connected to fundamental mathematical and algorithmic challenges at the intersection of multiscale modeling and simulation, uncertainty quantification and computational physics: (A) Numerical stochastic homogenization beyond stationarity and ergodicity, (B) Uncertainty quantification in truly high-dimensional parameter space, (C) Computational multiscale scattering in random heterogeneous media, (D) Numerical prediction of Anderson localization and quantum phase transitions. These objectives base upon recent breakthroughs of deterministic numerical homogenization beyond periodicity and scale separation and its deep links to seemingly unrelated theories ranging all the way from domain decomposition to information games and their Bayesian interpretation. It is this surprising nexus of classical and probabilistic numerics that clears the way to the envisioned new computational paradigm for multiscale problems at randomness and disorder.

Keywords: msc2010 65 xx numerical analysis,65mxx partial differential equations,initial value and time dependent initial boundary value problems,65nxx partial differential equations,boundary value problems,65zxx applications to physics
Antiseptic kaolin-silver complex for substituting the use of sulfites in winemaking (SILVERWINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Italy,Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

We, the consortium integrating SILVERWINE, composed by ENOSAN and NASTRI-TEX, will put in the market a product consisting on a kaolin-silver complex (KAgC) contained in an infusion bag, that has antiseptic properties for substituting the use of sulfites in winemaking. The KAgC is composed of microparticles of kaolin (99% weight) and nanoparticles of metallic silver (1±0.1% weight). It is insoluble and it has a minimum reactivity with the food matrix, because the kind of silver used is Ag0, which has biocidal power and leaves no chemical or physical residue, as KAgC complex does not contain any potential allergenic protein fraction or any known allergen. We are two Spanish SMEs, with complementary roles in the supply chain of this product, as LABORATORIOS ENOSAN (5 people) –the leader- holds the vast know-how of elaborating and dosing the KAgC for a correct use in winemaking, and NASTRI-TEX (12 people), a company with vast experience with textile materials y, contributes with the infusion bags in which the SILVERWINE complex is disposed. ENOSAN has been recently established (2014) but its team is formed by technicians with a vast expertise up to 30 years in kaolin-silver complex applications in agri-food –specially winemaking- and pharma, and NASTRI-TEX counts with 35 years of expertise in industrial technological filters elaboration mainly oriented to the highly demanding needs of cosmetic industry. With SILVERWINE we will cover a global need of winemakers: the substitution of sulphites (SO2), a controversial compound that wine industry has been trying to replace for decades.

Keywords: enology,winemaking,sulfite free wine,no sulfites,kaolin,silver,infusion
Synthesizing and Investigating the Exotic Electronic Properties of Two-Dimensional Metal-Organic Frameworks (EMOF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 1
Project status: CLOSED

Metal-organic frameworks (MOFs) are coordination polymers synthesized by bonding organic ligands with metals or metal clusters. Recently, exotic electronic properties have been predicted theoretically for two-dimensional (2D) MOFs, such as topological non-trivial band structure (2D organic topological insulators and so on), superconductivity, half-metallic ferromagnetism and quantum spin liquid. 2D MOFs have been synthesized on metal surfaces by following the concepts of supramolecular coordination chemistry. However, molecular adsorbates on metal surfaces interact strongly with the underlying metal substrate. Therefore, their electronic properties are drastically modified. This project will focus on synthesizing and investigating the intrinsic exotic electronic properties of 2D MOFs on insulating, weakly interacting, and tunable gated substrates by ultra-high vacuum low-temperature Scanning Tunneling Microscopy and Spectroscopy with non-contact Atomic Force Microscopy. In order to achieve these ambitious targets, I have divided this proposal into three work packages: 1. synthesizing 2D MOFs on inert surfaces; 2. structural and electronic characterization of 2D MOFs; 3. tuning the exotic electronic properties of 2D MOFs on gated graphene devices. The applicant and the host group have initial results on the topics discussed in this proposal and are thus in a unique position to make ground-breaking contributions in this area. Understanding and tuning the growth and the electronic properties of MOFs will offer a versatile platform to realize topological electronics as well as different kinds of novel phenomenon in condensed matter physics. The bottom-up synthesis techniques guarantee a technological route which can easily be scaled-up to be used for applications. Longer term, the biggest impact is expected through applications of MOFs in dissipationless electronics and spintronics.

Keywords: low temperature scanning tunneling microscopy lt stm,non contact atomic force microscopy nc afm,ultra high vacuum uhv,organic topological insulator oti,metal organic framework mof
Accelerating photoredox catalysis in continuous-flow systems (Photo4Future)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Spain,Australia,Germany,Spain,Belgium,Switzerland,Belgium,Hungary,France,France,United States,Netherlands
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 2248434.36
EU funding (EUR): 2248434.36
Participants: 13
Project status: CLOSED

The use of visible light energy to induce chemical transformations constitutes an interesting and green activation mode of organic molecules. However, implementation of this energy source in organic synthetic methodologies and in the industrial production of fine chemicals has been challenging. The Photo4Future Innovative Training Network establishes a training network with five beneficiaries from academia and five beneficiaries from industry to tackle the challenges associated with photochemistry in a coherent and comprehensive fashion. In total 13 Early Stage Researchers will be recruited within the Photo4Future network. The network will provide them with opportunities to undertake research with the aim to overcome the current limitations towards the applicability and scalability of photochemical transformations. This will be achieved through a rational design of novel photocatalytic methodologies, improved catalytic systems and innovative photoreactors. Furthermore, the ESRs will be trained in the Photo4Future graduate school, covering training in scientific, personal and complementary skills. All the ESRs will perform two secondments, of which at least one is carried out with an industrial partner. Consequently, the ESRs will have improved career prospects and a higher employability. Due to the high degree of industrial participation, the Photo4Future network will provide an innovation-friendly environment where scientific results can grow and become products or services that will benefit European economies.

Keywords: flow chemistry
Fiscal Consolidation, Unemployment and Labour Mobility in the Euro Area (EuroCrisisMove)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

In the aftermath of the crisis, unfavourable socio-economic conditions with high unemployment, steep decreases in salaries and welfare allowances, and deterioration in career prospects have triggered intensified labour mobility, with a direction from the so-called Peripheral countries to the Core of the euro area. Primarily due to the surge in immigration from its EU partners, Germany is now the second largest immigration country in the industrialised world, after the U.S. Fiscal consolidation policies that aim to reduce deficit levels and typically involve tax hikes and cuts in government spending have also contributed to these migration outflows from crisis-hit countries. Notably, in countries with a sizeable public sector, like Greece and Spain, cuts and restrictions in new recruitments of public employees have further motivated the decision to move abroad. The aim of this research is to theoretically study the macroeconomic links between unemployment, fiscal consolidation, and labour mobility in a monetary union. To this end, I will introduce endogenous migration decisions both for the unemployed and the employed household members in a two-country Dynamic Stochastic General Equilibrium model of a monetary union with search and matching frictions, in which the Periphery implements fiscal consolidation through spending cuts or tax hikes. Existing studies in the fiscal consolidation literature consider an immobile labour force and, therefore, the migration channel has not yet been investigated in this context. This project aims to fill this gap and inform policymakers by comparing different fiscal consolidation instruments: (a) labour income tax hikes, (b) public consumption spending cuts, (c) unemployment benefits cuts, and (d) public sector wage bill cuts. Through the lens of the model, I will also perform a systematic comparison of the implications for different euro area Peripheral economies, which have implemented a different policy mix in the recent years.
Screening of Gastric Cancer via Breath volatile organic compounds by Hybrid Sensing Approach (VOGAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Ukraine,Germany,Israel,Colombia,Sweden,Finland,Latvia,Chile,Brazil
Call: Translational collaborative cancer research between Europe and the Community of Latin American and Caribbean States (CELAC) (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2022-09-30
Duration (months): 45.0
Total project cost (EUR): 3781179.75
EU funding (EUR): 3781179.75
Participants: 12
Project status: CLOSED

Gastric cancer has good chances to be cured if diagnosed at an early stage; currently, there is lack of a reliable non-invasive screening tool. Eastern Europe and Latin America are among the geographical areas with high burden of the disease. This project is aiming at developing a non-invasive gastric cancer screening tool by detecting characteristic panels of volatile organic compounds (VOCs). The mechanisms of VOC origin and their composition in gastric cancer patients will be addressed via headspace analysis of cancer tissue, cell-lines, and bacterial flora; VOCs identified during this analysis will be compared to the compounds present in human breath, both via gas chromatography coupled to mass spectrometry (GC-MS). Based on this data, a new type of breath analyser will be developed and validated building upon previously acquired expertise of the consortium members. Specifically, the exhaled breath analyser will combine electronic nose concepts utilizing gold nanoparticles and metal oxide sensors with orthogonal mid-infrared spectroscopic techniques for obtaining multi-dimensional analytical data sets; furthermore, compact pre-concentration schemes will be evaluated. All components will be integrated into several prototypes of portable and optimized devices. The clinical studies will be conducted in parallel in European (Latvia, Ukraine) and Latin American (Colombia, Brazil, Chile) countries with high disease burden. Patients with gastric cancer and individuals with and without precancerous lesions (dysplasia, atrophy, intestinal metaplasia) will be enrolled. The role of confounding factors including H.pylori infection will be addressed. As the main result, we expect to provide the first reliable non-invasive gastric cancer screening device based on exhaled breath analysis concepts for future large-scale implementation. The development of according research competences and international collaborations therefore is the most vital component of this project.

Keywords: volatile organic compounds,breath analysis,cancer screening,gastric cancer
Virtue based ethics and Integrity of Research: Train-the-Trainer program for Upholding the principles and practices of the European Code of Conduct for Research Integrity (VIRT2UE)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Austria,Germany,Italy,Norway,Türkiye,Belgium,Finland,Greece,Croatia,Latvia,Netherlands,Portugal
Call: Implementing a European Train-the-trainers initiative with regard to Ethics and Research Integrity (H2020-SwafS-2017-1, 2017)
Start date: 2018-06-01
End date: 2021-11-30
Duration (months): 42.0
Total project cost (EUR): 2800000.0
EU funding (EUR): 2800000.0
Participants: 14
Project status: CLOSED

Consistent application and internalization of the principles listed in the European Code of Conduct for Research Integrity (ECoC) requires wide spread dissemination, innovative training program and novel tools. VIRT2UE aims to develop a sustainable train-the-trainer blended learning programme enabling tailored ERI teaching across Europe, focusing on understanding and upholding the principles of the ECoC. The learning programme will provide a toolbox of educational resources and incorporate an innovative online course with face-to-face sessions designed to foster moral virtues, and apply the content of the teaching material to concrete situations. The project will: conduct a conceptual mapping amongst stakeholders to identify and rank the essential virtues for good scientific practice and their relation to the ECoC’s principles; identify and consult ERI trainers and the wider scientific community to understand existing capacity and deficiencies in ERI educational resources; develop an innovative face-to-face train-the-trainer programme to provide trainers with tools to promote the ECoC and foster researchers’ virtues; create and update training materials for trainers and researchers; implement and disseminate the train-the-trainer programme across Europe, and build capacity and consistency by focusing on underdeveloped regions and unifying fragmented efforts; evaluate the training programme in terms of trainers’ and researchers’ needs, and use the evaluation results for further developing of the training and making a sustainability plan. VIRT2UE recognizes that knowledge of rules and codes is not enough to truly uphold and internalize the principles explicated in the code and integrate them in their everyday. VIRT2UE aims to take on this challenge by offering the development of a European-wide, innovative, blended learning programme which fosters knowledge of researchers in both academia and industry of the ECoC and its application, by providing tools for reflection.

Keywords: research integrity,virtue ethics,responsible research practices