Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Linking population genomic and behavioural data to test fundamental hypotheses of sexually antagonistic coevolution. (PopGenSexCon)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: CLOSED

Sexual conflict and sexually antagonistic coevolution (SAC) are compelling hypotheses to explain some of the extraordinary diversity in morphological and behavioral traits observed in nature. However, the study of the genomic foundations of this conflict and the resulting population genetic dynamics are still in their infancy. This is due to a lack of knowledge about the genetic underpinnings of the most well understood sexual conflict traits. An exception to this rule are the seminal fluid and female reproductive tract proteins that interact and mediate conflicts over remating rates in the cosmopolitan model species Drosophila melanogaster. However, in this system a population-level perspective to investigate population genomic signals of SAC and the consequences for outcomes of mating interactions within populations is lacking. Here I propose to take advantage of a Europe-wide population genetic data-set as well as an ongoing pan-European collaborative sampling and phenotyping effort of D. melanogaster to understand how sexual conflict has shaped co-evolutionary patterns at genetic loci involved in sexually antagonistic traits. Furthermore, I will investigate the consequences of this genetic coevolution on contemporary male-female interactions. My proposal has three objectives: i) a population genomic analysis of population genomic data from European D. melanogaster populations, ii) lab-based behavioural experiments to investigate the male-female interactions for inbred lines obtained from populations with extreme patterns of coevolution, iii) and indirect study of the consequences of coevolution on natural behaviour via sampling of wild-caught females and determining mating/re-mating rates. This project will increase our understanding of the role of sexual conflict and sexually antagonistic coevolution in population divergence and set a standard for investigations of the genomic causes and consequences of SAC.

Keywords: sexual selection,sexual conflict,mating behaviour
DNA Encoded Omniphobicity (WETDNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Türkiye
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Encoded surfaces have a rich set of applications that range from anti-counterfeiting to sensing. A desirable characteristic is the synergetic combination of molecular specificity with macroscopic changes that can be detected with simple infrastructure. Wetting is a macroscopic property, with transitions identifiable even with the naked eye. As the genetic information carrier, DNA is perfectly suited for molecular encoding. A grand challenge is generating macroscopically visible changes in wetting properties with sequence-specific interactions between DNA oligonucleotides. WETDNA will address this rewarding challenge by linking DNA encoding with localized wetting properties. WETDNA requires rational design of systems with components that span several orders of magnitude in length scales. To understand structural effects on the wetting-based encoding, microscopic liquid pinning sites are first fabricated by adaptation of lithographic processes with mechanochemical grafting, which is a concept recently developed in my laboratory (WP1). Printing of oligonucleotides and chemical coupling to liquid pinning sites will then mediate multiplex DNA encoding over wetting patterns (WP2). A key step in linking Watson-Crick base pairing and macroscopically visible localized wetting properties is generating omniphobicity over DNA-informed surfaces by grafting liquid-repellent polymers (WP3). In the presence of complementary DNA molecules, patterns will be unlocked to reveal wetting features that can be read-out at multiple levels (WP4). WETDNA is structured to exploit this unlocking mechanism for authentication of deterministically and stochastically defined wetting features (WP5). The understanding of the principles that govern DNA-driven wetting-based encoding is expected to generate knowledge at the intersection of physical, chemical, and biological sciences with major impact in adaptive and smart surfaces, anti-counterfeiting, sensing, environmental monitoring, and diagnostics.

Keywords: wettability,dna,surfaces,anti counterfeiting
Moldovan Horizon Europe Office - Empowering Research, Expanding Horizons (M-HERO)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Euratom
Destination: Euratom
Action type: Coordination and support actions
Countries involved: Moldova, Republic of
Call: Strengthening Moldova's Horizon Europe Ecosystem: Expanding the Reach and Capabilities of the Horizon Europe Office (HORIZON-EURATOM-2025-MOLDOVA-IBA, 2025)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 943750.0
EU funding (EUR): 943750.0
Participants: 1
Project status: SIGNED

The project proposal addresses the critical need to enhance Moldova's integration into the European Research Area and maximize participation in Horizon Europe. As an Associated Country, Moldova faces significant structural challenges in its R&I ecosystem despite its promising foundations and EU association status. This project will systematically strengthen the operational capacity and professional expertise of Moldova's Horizon Europe Office and NCPs network through five specific objectives: (1) enhancing institutional capacity and operational efficiency; (2) improving proposal development skills and success rates; (3) fostering strategic international research partnerships; (4) increasing awareness of Horizon Europe opportunities; and (5) establishing robust monitoring and sustainability mechanisms. The methodology employs a strategic framework emphasizing quality-driven implementation, digital-first approaches, decentralization of services, complementarity with existing initiatives, localization of support, and institutionalization of best practices. Implementation follows a structured progression through interconnected work packages focusing on a Business Process Management System development, human resources capacity building, support services delivery, communication and dissemination, and effective project management. Expected outcomes directly address the call requirements: a strengthened and professionalized NCP system providing consistent, high-quality support services; harmonized practices aligned with EU standards; enhanced capacity of researchers; and increased participation rates. Long-term impacts include advanced ERA integration, reduced R&I divides and support for Moldova's broader European integration aspirations.

Keywords: horizon europe participation,national contact points,european research area integration,randi support system,republic of moldova
Objects of Pleasure. The Contribute of Anthropological Material Culture to the Emergence of Sexual Science (1870-1940). (OBSEX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2030-02-28
Duration (months): 42.0
Total project cost (EUR): 445401.9
EU funding (EUR): 445401.9
Participants: 4
Project status: SIGNED

OBSEX explores the crucial, yet overlooked, role that anthropological material culture played in the emergence of sexual science. I argue that, from its outset (1870-1940), Western research on sexual behaviours was not just medical, but that anthropological investigation had a crucial role in making pleasure and desires key interests in the production of scientific knowledge on sexuality. In this way, OBSEX questions Michel Foucault’s dichotomy between an ‘Oriental’ Ars Erotica and a Western Scientia Sexualis by demonstrating that, European scientific knowledge on sexuality was not just focused on pathology, but it was comprised of discourses addressed to pleasure. During OBSEX, I will complement my background in cultural history with new historical scientific and museological skills, crucial to understanding the role of anthropological objects in the development of sexual science. I will use Italy and Britain as main cases to trace the scientific collection, cataloguing and study of the material evidence of ‘primitive’ sexualities (amulets, ornaments, pleasure devices, medical instruments) by anthropologists, folklorists and museum curators, and the impact of their work on sexological theories. I will detect and deconstruct colonialist and gendered narratives embedded in sexological discourses. I will demonstrate that the study of anthropological material culture was not only used to prove the backwardness of the sexuality of the 'Other', but also served a scientific interest on common human features, such as the pursuit of pleasure. In this way, I will be able to show how the study of objects embedding the sexuality of the ‘primitive’ Other had a crucial role in the development of European sexual knowledge and was used as a mirror to read ‘civilised’ sexuality. Showing that from its outset sexual science considered pleasure and desire as constitutive elements of being human, OBSEX will place pleasure at the core of today European debate on sexual health rights.

Keywords: history of sexual science sexuality sexual pleasure anthropology folklore italy britain scientific museums material culture digital humanitites nineteenth century history sexual rights
Photoacoustic imaging and artificial intelligence-based theranostic approach for cancer (PHIRE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Netherlands,Belgium,United Kingdom
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 2084871.88
EU funding (EUR): 2084871.25
Participants: 5
Project status: SIGNED

Health programs crave for diagnostic imaging and eradication of chemoresistant neoplastic lesions smaller than 1 mm of size. PHIRE, based on the outcomes from EDIT (FET-OPEN-RIA, GA#801126), aims at bringing closer to market a novel high-resolution theranostic medical device effective in the clinical applications for lesions <1 mm, ready for application in human bladder cancer and effective both in male and female patients. The PHIRE solution will be developed using swine model and will include: - an add-on module for pre-existing off-the shelf photoacoustic device allowing to perform photoacoustic imaging of hollow organs located deeper in human body, designed to be used in combination with - an artificial intelligence-assisted prediction map for the image-guided gold nanorods assisted photo-thermal therapy, - a large-scale synthesis of urine-stable gold nanorods for clinical use. The adoption for clinical applications of this new device will reduce the frequency of the bladder tumor relapse and the number of patients with relapsing tumor, with a drastic positive impact on the quality of life of patients while reducing the social cost of the management of patients. Furthermore, PHIRE’s results will open up the way for the deployment of theranostic application against lesions <1 mm in other hollow human organs. PHIRE innovative solutions will also be applicable to other markets, such as that of photoacoustic and diagnostic imaging, gold nanoparticles, cystoscopy and medical software.

Keywords: high resolution theranostic approach artificial intelligence cystoscope gold nanorods good manufacturing practices photothermal therapy bladder cancer
Organ-on-a-Chip Focused Strategic Partnership (OrChESTRA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Türkiye,Netherlands,Belgium,Germany
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1492927.5
EU funding (EUR): 1492927.5
Participants: 4
Project status: SIGNED

OrChESTRA project aims to build solid and productive links between ODTÜ MEMS (Turkey) and three internationally-leading counterparts; TU/e (The Netherlands), IMEC (Belgium), and UFR (Germany), in order to strengthen scientific and research capacity of BioMEMS Research Unit of ODTÜ MEMS by raising the research profile of its staff and broadening its recognition as a centre of excellence in the field of microfluidics, biosensors, and particularly organ-on-a-chip systems. With the four twinning partners in place, ODTÜ MEMS aims to acquire the expertise needed not only to fill the identified gaps regarding knowledge, capacity, and networking, but also to join leading networks of excellence in microfluidics, biosensors, and organ-on-a-chip based research areas as an equal partner. The consortium expects to expand the R&D capabilities of the partners, to attract and provide scientific personnel via the OrChESTRA to the thematic focus of microfluidics, biosensors, and organ-on-a-chip systems, contributing to critical mass for the widespread application of such promising systems. Empowering the partnering organisations will result in knowledge transfer, joint publications and future research projects. The consortium is strongly committed to further develop this partnership with a long-term sustainable horizon of cooperation beyond the project. Consequently, OrChESTRA project aims to promote new opportunities for the consortium members via development of productive and sustainable links among them for higher levels of excellence in the field of microfluidics, biosensors, and organ-on-a-chip platforms, with a major focus on enhancing the range of competences of the coordinator. Objectives dedicated to achieve this goal: 1. Raising the research profile of ODTÜ MEMS and its researchers 2. Enhancing institutional capacity of ODTÜ MEMS 3. Excellence in the wider impact for the ecosystem and beyond 4. Integration into European networks of excellence

Keywords: twinning,eu integration,organ on a chip,microfluidics,biosensors
Walls and Wicked Problems: The Role of Complexity in Politics (COMPLEXPOL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499899.25
EU funding (EUR): 1499899.0
Participants: 1
Project status: SIGNED

Politics is about solving our world's most complex problems. Solving “wicked problems” like climate change or migration involves myriad actors, contested priorities, uncertain outcomes, and interdependent processes. In the face of such complexity, policymakers sometimes propose simple solutions. US President Donald Trump proposed building a wall to “solve” immigration. British Conservatives proposed cutting all ties with the EU in a “hard Brexit”. Both won elections on these simple narratives. Conversely, the lack of a similarly simple idea to address climate change seems to hinder global progress. Each of these events is a story of a contest between complex and simple ideas. Yet political science lacks clear theories about the nature and strategic uses of complexity, focusing mostly on text complexity measures like readability. Without a theory of idea complexity, scholars cannot explain why Trump proposed a wall, nor why the idea was popular with voters. If we understand political complexity better—if we make it explicit instead of implicit in our theories—we also understand our current moment better. COMPLEXPOL will build new theories of and evidence for the role of complexity in politics. It does so through three work packages that rely on multiple methods, including quantitative modelling, survey, experimental, and computational methods, and novel data on voters and political leaders in three countries. In WP1, I will develop new, multidimensional measures of complexity, particularly of ideas. In WP2, I will explore the social and psychological determinants of individual attitudes toward complexity. And in WP3, I will investigate the strategic use of complexity by leaders and the public's reactions. In so doing, COMPLEXPOL will provide fresh insights into why some problems get solved with walls while others are left as wicked problems.

Keywords: complexity,political psychology,information theory
Isotopes in Sublimation by Laboratory and In-field Meteorological Experiments (iSUBLIME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland,Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-09-30
Duration (months): 25.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: SIGNED

Snow and ice influence the Earth’s hydrological cycle and radiation balance and therefore are prime factors governing the climate and water resources. Snow storage and ablation by melting and sublimation play a crucial role in numerous atmospheric, ecological, and ecosystem processes. While the processes related to the isotopic mass exchange during sublimation of snow are well understood, the parameterization of snow sublimation, which is critical to improving the predictive modelling of the fate of snow in the present and near future, remains an important problem to be addressed. The primary question of this project is: what are the key processes that control the patterns and magnitude of snow sublimation fluxes to the atmosphere? This question will be addressed through i) high temporal resolution measurements of snow properties, natural isotopic tracers, and micro-meteorological conditions in the field and ii) controlled environmental chamber experiments in the laboratory. Field measurements will be performed at Pallas (Arctic) and Sodankylä (sub-Arctic), Finland above the snow surface (open ground and forest canopy). Control experiments will be carried out in the Cold Climate Container (CCC) at the University of Oslo, Norway. The aim will be to understand the mass transfer between snow and atmosphere, by measurements of the stable isotopes of hydrogen and oxygen in solid (snow), liquid (snow-melt) and vapor phase. By performing these experiments and measurements, the primary target would be to constrain the isotopic signature of sublimation flux and develop a model to simulate isotopic interactions between the snow layer and atmosphere. The findings from this study will have a multidisciplinary impact on understanding the influence of snow sublimation on atmospheric and terrestrial water balance in the snow-dominated regions of the world

Keywords: sublimation,stable water isotopes,eddy covariance,arctic
Synthetic generation of hematological data over federated computing frameworks (SYNTHEMA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Austria,Netherlands,France,Germany,Portugal,Luxembourg,United Kingdom,Belgium
Call: Scaling up multi-party computation, data anonymisation techniques, and synthetic data generation (HORIZON-HLTH-2022-IND-13, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 6514560.0
EU funding (EUR): 6514560.0
Participants: 16
Project status: SIGNED

Haematological diseases (HDs) are a large group of disorders resulting from quantitative or qualitative abnormalities of blood cells, lymphoid organs and coagulation factors. Despite most of them (~74%) are rare, the overall number of HD affected patients worldwide is important, placing a considerable economic burden on healthcare systems and societies. Despite the existence of several collaborative research groups at national and EU level, current clinical approaches are often ineffective, particularly for rarest conditions, due to the relatively low number of patients per disease and the high number of unconnected clinical entities. SYNTHEMA aims to establish a cross-border data hub where to develop and validate innovative AI-based techniques for clinical data anonymisation and synthetic data generation (SDG), to tackle the scarcity and fragmentation of data and widen the basis for GDPR-compliant research in RHDs. The project will focus on two representative RHD use cases: sickle-cell disease (SCD) and acute myeloid leukaemia (AML). SYNTHEMA will develop a federated learning (FL) infrastructure, equipped with secure multiparty computation (SMPC) and differential privacy (DF) protocols, connecting clinical centres bringing standardised, interoperable multimodal datasets and computing centres from academia and SME. This framework will be utilised to train the developed algorithms and perform SMPC-based global model aggregation in a privacy-preserving fashion. The resulting data will be validated for their clinical value, statistical utility and residual privacy risks. The project will develop legal and ethical frameworks to guarantee privacy by-design in the collection and processing of health-related personal data and attain an ethics-wise algorithm co-creation. Project outcomes, including pipelines, standards and data, will be made openly available to stakeholders in the healthcare, academia and industry field, and contribute to existing rare disease registries

Keywords: synthetic data generation,rare hematological diseases,disease management