Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Geographic environments, daily activities and stress: a study on the space-time fragmentation of exposure patterns (FragMent)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Luxembourg
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1496821.0
EU funding (EUR): 1496821.0
Participants: 1
Project status: SIGNED

Stress is nearly ubiquitous in everyday life, and imposes a tremendous burden worldwide by acting as a major risk factor of mental disorders, autoimmune, infectious and cardiovascular diseases, and some cancers. The aim of the FragMent project is to evaluate to which extent the spatial and temporal fragmentation of exposures to environments in daily life influences physiological and psychological stress, as well as social inequalities in stress. Some evidence shows that exposures to daily environments may either act as a stress contributor or provide some stress restorative qualities. While the protective effect of greenness has been clearly established, strong uncertainties remain regarding the effects of urban environments. FragMent starts from this premise to investigate the environmental determinants of momentary, daily and chronic stress in relation with immediate, daily and regular environmental exposures. The project uncovers the role of spatiality and temporality in exposure effects on stress. It further builds on the concept of space-time activity fragmentation, to contextualize patterns of exposure within activity patterns. Finally, it analyses how differences in space-time exposures and activity patterns across social groups may lead to social inequalities in stress. An observational cohort study will be used to evaluate momentary, daily and chronic stress in daily life, using a combination of traditional web-survey, map-based questionnaires, smartphone tracking and Geographic Ecological Momentary Assessment. A series of lab-based experiments, combining Immersive Virtual Environments with a walking simulator, will assess the effect of urban environmental characteristics and the temporality of exposures on momentary physiological and psychological stress. Bridging knowledge from epidemiology and time geography, FragMent will provide critical evidence to equitably reduce exposure to environmental stressors in outdoor space in everyday life.

Keywords: stress environmental exposure neighborhood effects activity space concept of fragmentation activity patterns daily mobility
CogBooster: Rebooting Psychological Research through Cognitive Neuroscience (CogBooster)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2499827.5
EU funding (EUR): 2499827.5
Participants: 1
Project status: SIGNED

CogBooster aims at contributing to closing the research gap in Psychology between Widening and non-Widening countries by implementing a strong line of research in the area of Cognitive Neuroscience at the Psychology Department of the University of Coimbra, Portugal. It will do so under the leadership of one of the most respected and highly cited researchers in the fields of Psychology and Cognitive Neuroscience – Alfonso Caramazza. Importantly for CogBooster, Alfonso Caramazza successfully created and led research centers and departments to excellence in the field of Psychology and Cognitive Neuroscience, both in the United States of America, as well as in Europe. CogBooster will promote an institutional reform to align the Coordinator Institution with the cutting-edge psychological research and education currently provided in the Psychology Departments within non-widening European countries, and in the top Psychology Departments in the world. A close inspection of the major differences between Psychology Departments in Widening and non-Widening countries suggests that the presence of strong and dominant lines of research in Cognitive Neuroscience marks the divide between these two groups of countries in what concerns Psychology. To contribute to closing this research gap and increasing research quality and competitiveness at the University of Coimbra, the institutional reform under CogBooster will focus on: 1) attracting talents in the area of Cognitive Neuroscience to Portugal; 2) improving research and education, by providing top notch training in an area that is central for resolving complex societal challenges; and 3) bringing these scientific outputs to society. Overall, the scope of this action extends to the whole system: academia, target users (e.g., students), and the wider community. A group of prestigious and influential Cognitive Neuroscientists will advise on the different steps of the project, providing also a clear view for the future of Psychology.

Keywords: cognitive neuroscience scientific literacy
Tuneable Conditional Control of Engineered Bacterial Therapeutics (BACTOCONTROL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Engineered microbes are attractive platforms for the diagnosis and treatment of several diseases. For example, bacteria can selectively target tumors and are ideal vehicles for in situ delivery of therapeutic agents. However, as of today, no engineered living bacterial therapeutics in clinical trials have the ability for conditional control of therapeutic activity. This lack of reliable control over the timing and dosage of effector molecule production limits the specificity, safety, and efficacy of current bacterial therapies. In this project, I will use of a generalizable synthetic receptor platform to control the in vivo therapeutic activity of engineered bacteria using an externally administered molecules. As a proof of concept, I will use a receptor responding to a molecule found in the diet to control therapeutic release in tumors. I will use a safe probiotic, E. coli Nissle 1917, with demonstrated tumor targeting properties. In a first research line, I will characterize the dose-response and kinetics of synthetic receptors implemented in bacteria colonizing an in vitro 3D tumor spheroids model. I will then evaluate the therapeutic activity of strains producing cytolytic molecules in response to external inducer. In a second research line, I will characterize conditional control of gene expression and then therapeutic release in tumor mice model, using cytolytic and immunotherapeutic effectors. My work will deliver robust, safe, and efficient frameworks for conditional control of bacterial cancer therapy. By enabling in situ drug delivery with a highly-precise dosage and timing, it will allow physicians and ultimately the patients to finely control bacterial therapeutic activity. Because of its modularity my platform will be further engineerable to detect other conditional inducers. This system will be reusable for the treatment of many other pathologies, including autoimmune and infectious diseases.
Nature Based Solutions for Atlantic Regional Climate Resilience (NBRACER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Netherlands,Spain,France,Belgium,Portugal,Italy,Germany,Denmark
Call: Testing and demonstrating transformative solutions on climate resilience, mainstreaming nature based solutions in the systemic transformation (HORIZON-MISS-2022-CLIMA-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 18140252.02
EU funding (EUR): 17438626.25
Participants: 33
Project status: SIGNED

The impacts of climate change on people, planet and prosperity are intensifying. Many regions and communities are struggling to avoid losses and need to step up the effort to increase their climate resilience. Ongoing natural capital degradation leads to growing cost, increased vulnerability, and decreased stability of key systems. Therefore, the European Mission on Climate Adaptation acknowledges the need to adopt a systemic approach by working across sectors and disciplines, experimenting, and involving local communities. NBRACER steps up to this challenge with an innovative and practical approach to accelerate the transformation towards climate resilient regions that are safe, green, clean, healthy, and just. Adaptation will be based on the smart packaging of nature-based solutions (NBS), rooted in the resources supplied by biogeographic landscapes, and embedded in a transformative action approach that mobilizes and enables regions and communities to accelerate forward. NBRACER works with Demonstrating and Replicating regions in the European Atlantic biogeographical area to vision and co-design place based sustainable NBS that are at one with the regional landscapes, upscaling these into coherent regional packages and building time and place specific adaptation pathways integrating local solutions and regional scales. This process is supported by a regional scale effort to build adaptation journeys with community support, with input from teams testing and validating place based NBS solution portfolios situated in landscapes. Innovative technical and adaptation transformation support packages provide quantitative mapping methods and a transformative action approach and capacity building, and networking enable scaling out and building connections. Led by Deltares, advanced in climate adaptation science, the consortium builds synergy from the strength of practitioners, ecosystem engineers, innovators of transformative adaptation, finance, and capacity building experts.
GreenH2 production from water and bioalcohols by full solar spectrum in a flow reactor (GH2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Germany,Ireland,Italy,Switzerland,United Kingdom,Hong Kong
Call: Novel routes to green hydrogen production (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 2201654.72
EU funding (EUR): 2201654.72
Participants: 8
Project status: SIGNED

Water splitting for H2 production driven by solar energy is quite attractive while the current efficiency is very moderate due to both the extremely sluggish water oxidation half reaction and limited light harvesting (mostly UV-visible light). In addition, the separation of one product H2 from the other O2 during water splitting is very costly. The project is designed to address these challenges by i) utilizing the full solar spectrum (300-2500nm) instead of UV-visible light (300-700nm), ii) coupling water splitting with biomass-derivative oxidation to avoid water oxidation, iii) well combining solid Z-scheme UV-visible photocatalysis and Infrared-driven thermal catalysis, and iv) using a flow double tube reactor other than batch reactors, thus targeting to produce green H2 from both water and biomass with a high quantum yield of 60% . Furthermore the project will co-produce high-value chemicals with a high selectivity of >90%. In addition, the integration of low-cost and efficient catalysts with novel flow reactors will assure a continuous and efficient production of H2 and high-value chemicals. The entire process does not use fossil fuels nor produce CO2, thus a zero carbon-emission technology. Finally the system can be readily scaled up by numbering up the reactor modules. All these are built upon a multidisciplinary and international consortium with the global experts in photocatalysis, thermal catalysis, reactor engineering, product separation, simulation and social science. Therefore the scientific and technical challenges, as well as the environmental, societal and economic impacts will be fully addressed in the project. The proposed technology will typically benefit the EU economy by an innovative green H2 production process from water and biomass, heavily contributing to a low carbon society. In addition, the international team including members from Asia will facilitate the technology exploitation out of the EU, to further benefit the EU economy.

Keywords: green h2 production,full solar spectrum utilization,biomass reforming,double tube flow reactor,solid z scheme
Pro-Democracy Platform Advocacy: Fostering Social Media's Accountability to Dissident Voices under Authoritarianism (ProPA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: SIGNED

Digital platforms, such as Facebook and Twitter, have long touted themselves as defenders of freedom of expression, yet their content moderation rules have faced global criticism, amongst others for failing to tackle authoritarian repression of dissident voices. Government trolls successfully run malicious reporting campaigns that result in the platforms’ removal of activists’ posts and accounts. Meanwhile, civil society under authoritarianism lacks means of legal recourse and can only engage in international advocacy to urge social media companies to implement safeguards. To which extent have advocacy efforts for protection of pro-democracy content led to changes in digital platforms’ content moderation rules? Have these changes resulted in a more open online civic space for pro-democracy activism? What limitations remain? To address these questions and foster platform accountability for vulnerable users, I will work under Prof. Trisha Meyer’s supervision at Vrije Universiteit Brussel (VUB) - Centre for Digitalisation, Democracy and Innovation (CD2I) at Brussels School of Governance (BSoG) and Sam Gregory’s secondment supervision at WITNESS Inc. to achieve two main R&I objectives. First, the project will build and test a theoretical model of pro-democracy platform advocacy, based on original evidence from Asian pro-democracy movements and their advocacy toward three social media platforms (Facebook, Twitter, and Telegram). Second, the findings will be turned into two open-access academic articles and three applied innovations, including a best practice guide for pro-democracy activists, a set of policy recommendations for social media companies, and a digital advocacy resource for social media users. I will disseminate and exploit these results via presentations at eight academic and three multi-stakeholder conferences, publications on Open Research Europe platform, and five facilitation workshops with activists and meetings with social media companies.

Keywords: internet governance,platform governance,digital rights,transnational advocacy,asia,southeast asia
Multi-omics characterization of descending motor circuits in the brainstem (ReticulOme)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1998045.0
EU funding (EUR): 1998045.0
Participants: 1
Project status: SIGNED

The execution of coordinated and adaptive movements is the final manifestation of virtually all brain processes. Altered motor function is hence an associate feature of almost all conditions that affect the nervous system and is highly debilitating. This program will shed new light on the neuronal basis of movements with a focus on the cooperative roles of the brain and the spinal cord for composing and orchestrating multifaceted and adaptive motor behaviors. Reticulospinal (RS) neurons of the brainstem reticular formation (RF) are pivotal for controlling the most vital movements. They have long been seen as a unified relay of command signals from various integrative centers upstream, to most, if not all, “executory” motor circuits downstream. Yet, based on recent findings and our ongoing work, we posit that RS neurons rather exhibit a substantial diversity and specialization by inputs and outputs that may support a form of selection and mixing of unitary components of composite motor behaviors. Imprinting from the advent of “multi-omics” strategies in the mouse model, we will intersect functional connectomics and single-cell gene expression (the transcriptome) to achieve a most comprehensive characterization of RS neurons’ diversity, specialization, and interactions with their upstream and downstream brain areas. We will first investigate the anatomo-functional organization of an already circumscribed subset of RS neurons for orchestrating orienting motor actions. We will in parallel investigate the role and connectivity of other RS neurons, and provide genetic hallmarks of new functionally-relevant subsets. Our results will propel forward our understanding of the complex organization of the RF, its role in orchestrating composite movements, and its links with the rest of the brain. They will also provide new genetic hallmarks of RS neurons’ diversity which will be precious handles to ultimately examine and act on specific cell types in post-traumatic contexts.

Keywords: motor control neuronal circuits spinal cord brainstem reticular formation reticulospinal neurons optogenetics calcium imaging synaptic viral tracings
Building momentum and trust to achieve credible soil carbon farming in the EU (CREDIBLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Coordination and support actions
Countries involved: Spain,Italy,Belgium,France,Germany,Finland,Slovakia,Greece,Netherlands
Call: Network on carbon farming for agricultural and forest soils (HORIZON-MISS-2022-SOIL-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 3067095.0
EU funding (EUR): 3067095.0
Participants: 22
Project status: SIGNED

The main goal of the CREDIBLE project is to build momentum and trust for the implementation of carbon farming in the EU. This will be primarily achieved by setting up and moderating a network of initiatives/projects/stakeholders (referred to here as the Network of Networks - NoN) for favouring transparency, environmental integrity, and methodology standardisation in soil carbon accounting. Such a NoN will be responsible for pushing forward multiple discussions (articulated around three main themes: which practises; what standards; how to monitor) and is expected to evolve from a mostly technical/scientific network at the onset of the project, into a process catalysing policy making and business innovation toward its end. The transparent, open access, multi actor dialogues required to build trust and co-create solutions will be orchestrated around three annual European Carbon Farming Summits, which will present opportunities for the NoN to interact with the broader stakeholder community and grow to the point it would attract further fundings for long term sustainability. Through the action, four specific objectives will be achieved: O1) to build and disseminate a practical toolbox for promoting carbon farming, capable of taking into account local land uses, best practices, and multi-actor interests; O2) to identify options for benchmarking and selecting standards, certification mechanisms, and policy instruments for carbon farming; O3) to favour the establishment of a network of soil carbon data collectors and repositories to improve measuring and monitoring carbon dynamics; O4) to build up processes and tools to drive conversations for the upscaling of carbon farming. CREDIBLE’s ambition is to support the European Commission and the Expert Group on Carbon Removal in the identification and upscale of solutions for soil carbon farming.

Keywords: climate change mitigation,soil carbon capture and storage ccs,nature based solution
The Viral Imaginary: Between Crisis and Routine (VICR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: CLOSED

This action interrogates the social and cultural interpretations and narratives of viruses in Asia. It focuses specifically on how viruses have been historically narrated, interrogating the framings of viruses as routine versus viruses as crisis. To examine these framings, this action will interrogate the historical layering mobilized in Asian popular culture. By analyzing these reflections of viruses alongside how people respond to them, the action will query how historical parallels are used to narrativize the virus, making “the virus” a knowable entity. The overall goal of this action is to elicit the lessons learned from these social and cultural interpretations that can be compared to Europe and the world.

Keywords: viruses,popular culture,asia,south korea,hong kong