Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identifying the Capabilities and Limitations of CRISPR in Targeting G-quadruplex Forming Sequences: From Target Recognition to Gene Expression Regulation (CRISPR-GQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2019-06-30
Duration (months): 12.0
Total project cost (EUR): 88799.4
EU funding (EUR): 88799.4
Participants: 1
Project status: CLOSED

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated proteins (Cas) have recently been at the forefront of genomic research due to their enormous potential at editing the genome with great precision and specificity. A world-wide effort is currently underway to test Cas proteins and their variants for applications geared towards genome editing for human cells. How CRISPR-Cas systems perform in editing sequences that form non-canonical DNA or RNA secondary structures or are in the vicinity of such structures is the problem we wish to pursue during the course of proposed studies. One such structure is the G-quadruplex (GQ), which has been demonstrated to form throughout the human genome, with particular concentration in telomeric sites, promoters, and 3’ and 5’ untranslated regions of RNA. The higher frequency of potentially GQ forming sequences (PQS) at such regulatory sites has suggested a potential role for these structures in transcription or translation level gene expression regulation. GQ formation has been demonstrated to inhibit gene expression for a number of different genes, including certain critical oncogenes. Inability to remove these structures is directly associated with several syndromes, including Bloom and Werner syndromes, and neurological disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Therefore, editing such sequences to prevent GQ formation also has therapeutic potential. We will design different single guide RNA constructs and target the GQ forming G-rich or the complementary C-rich strand to elucidate the capabilities and limitations of the CRISPR-Cas9 system in editing such structures using single molecule techniques and bulk assays. We will then investigate whether CRISPR-Cas9 can be used to regulate gene expression by targeting GQ structures in the promoter region of tyrosine hydroxylase and c-Myc genes in the presence and absence of GQ stabilizing small molecules.

Keywords: crispr,cas9,g quadruplex,single molecule,fret,gene expression regulation
Spin Wave Computing for Ultimately-Scaled Hybrid Low-Power Electronics (CHIRON)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Greece,Romania,Belgium,France,France,France,Netherlands,Netherlands
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 3745607.5
EU funding (EUR): 3745607.5
Participants: 10
Project status: CLOSED

The future miniaturisation of electronic circuits following Moore’s law will require the introduction of increasingly disruptive technologies to limit power consumption and optimise performance per circuit area. CHIRON envisions spin wave computing to complement and eventually replace CMOS in future microelectronics. Spin wave computing is a paradigm-shifting technology that uses the interference of spin waves for computation. Spin wave computing has the potential for significant power and area reduction per computing throughput while reducing cost by alleviating lithography requirements. As a first step towards the vision of a full spin wave computer, CHIRON envisions hybrid spin wave–CMOS circuits that can be readily integrated alongside CMOS. CHIRON targets a proof of principle of the essential elements for spin wave computing by an interdisciplinary approach joining partners with expertise in material science, physics, nano-manufacturing, electrical engineering, device simulation, and circuit design. CHIRON will fabricate basic logic gates, such as inverters and majority gates, demonstrate their operation, and assess their performance. As transducers between the CMOS and spin wave domains in hybrid circuits, CHIRON will develop magnetoelectric and multiferroic nanoresonators, based on nanoscale bulk acoustic resonators, which bear promise for high energy efficiency and large output signal. The targeted lateral scale (100 nm) and resonance frequency (>10 GHz) bring such resonators to the frontier of nano-electromechanical systems (NEMS). This technological proof of principle is complemented by the design of digital hybrid spin wave–CMOS circuits that show the advantages of spin wave computing and can be integrated into a CMOS environment. Based on calibrated compact device models, the performance of these circuits in terms of power, area, and throughput will be benchmarked against CMOS to demonstrate their viability.

Keywords: spin waves,majority gate,wave computing,magnetoelectric effect,multiferroics,nanoelectromechanical resonator,magnonics
Podbike - electric assisted velomobile (Podbike)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2019-02-28
Duration (months): 9.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Podbike is an innovative Norwegian SME established in 2016 that has developed a game changing electric assisted velomobile that will transform personal transport in urban areas. The company’s mission is to accelerate the uptake of sustainable transport by bringing the Podbike to mass market as soon as possible. The velomobile targets the markets for private transport in urban areas in Europe with over 100 000 inhabitants, with beachhead markets in Norway, Denmark and Sweden. The total addressable market for these sales territories are 365 million Euro per year. Sales numbers in bigger markets, such as Netherland and Germany, opens the opportunity to scale the production and sales further. The Podbike is unique in three ways. Firstly, Podbike as a product is unique since it is specially designed to meet the high demands today's consumers has to a personal vehicle's design, comfort, functionality and safety. Secondly, Podbike approach to the entire value chain and corresponding business model is new and innovative. Thirdly, Podbike is disruptive since it takes a niche market product of electric assisted velomobiles and turn it into a cool, fun and comfortable product attractive for the mass market. Based on end users’ prioritized characteristics for acquiring a personal transport vehicle, Podbike outperforms the state of the art solutions in the existing markets segments in the following way: • Cars and electric vehicles (EVs): on price, environmental profile and transport effectiveness. • E-bikes: on safety, design, comfort and bad weather protection.
DNA Data Storage Technology for a Sustainable Digital Future (DATANA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Slovenia
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-05-01
End date: 2024-02-29
Duration (months): 34.0
Total project cost (EUR): 2667250.0
EU funding (EUR): 1867075.0
Participants: 1
Project status: SIGNED

BioSistemika is developing a DNA data writing technology, which is addressing the growing global problem of insufficient storage supply of the escalating world’s production of digital data. By 2025, the worldwide production of data will grow to 175 zettabytes, which is 10 times the amount of data humanity produced in 2017. The gap is rapidly widening and we will not be able to store more than 20% of produced data by 2025, a scenario which poses a serious risk to our entire digital ecosystems and digital safety. Today, digital data is predominantly stored in large datacentres that are a major contributor of CO2 emissions and a growing environmental concern. This even further promotes the urgent need of our society to shift the paradigm towards more sustainable storage technologies. DATANA is a patented innovation that enables this shift by utilizing DNA as an abundant, sustainable, and stable solution for the storage of data. As such, DNA has a lifespan of 1000+ years and the capacity to hold 20-million times more data per gram of substance than any other existing storage technology. Due to the high costs of DNA synthesis, the utilization of DNA for data storage is today still too expensive and time consuming to be used commercially. DATANA solves this issue by using a patented data encoding algorithm and a proprietary liquid handling system that reduces the volumes of DNA synthesis to picolitre range (one billionth of a milliliter). By doing so, it enables economically viable DNA storage of data for the first time. This represents a remarkable breakthrough and a major stepping stone for humanity, as it enables us to encode data into DNA at a cost comparable to the storage media used today. The project goal is to further optimize and scale-up our technology, which will allow for the demonstration of its potential at a commercially relevant scale and enable commercialization on the global data storage market by 2023.

Keywords: data storage
Integrated absolute dating approach for terrestrial records of past climate using trapped charge methods (INTERTRAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Romania
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2022-03-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The practice of tuning different climate proxies prevents the observation of regional response times of terrestrial archives to global changes. Thus, it is imperative to develop correlation protocols based on absolute chronologies. Loess-palaeosol deposits are continental archives of Quaternary paleoclimates and loess is generally considered an ideal material for the application of luminescence dating. The agreement obtained for 10-20 ka ages using different techniques has given us confidence in using the state of the art measurement protocols for young deposits, as confirmed by comparison with independent age control. INTERTRAP proposes detailed investigations of loess samples from three continents collected in close proximity to the transition to the recent soil, with the purpose of obtaining a temporal quantification of the ending of the Late Tardiglacial and the beginning of the Holocene. However, a series of recent luminescence investigations carried out on quartz of different grain sizes extracted from Romanian and Serbian loess yielded severe age discrepancies for ages >~40 ka. While the cause of this observation is hitherto not fully explained, our ongoing studies on Chinese loess prove that it is a general effect, potentially affecting deposits worldwide, and raising doubts on previous chronologies. Methodological studies within INTERTRAP will develop an integrated approach using optically stimulated luminescence, thermoluminescence and electron spin resonance investigations. This part of the study aims at unravelling the mechanism responsible for the observed discrepancies and developing innovative trapped charge dating measurement protocols based on quartz that will yield reliable ages for and beyond the last interglacial glacial cycle.

Keywords: optically stimulated luminescence dating osl,thermoluminescence tl,electron spin resonance esr,quartz,loess
Peer Powered Cities and Regions (PROSPECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Austria,Belgium,Greece,Slovakia,France,Netherlands,Netherlands,Portugal
Call: Engaging and activating public authorities (H2020-EE-2016-CSA, 2016)
Start date: 2017-06-01
End date: 2020-11-30
Duration (months): 42.0
Total project cost (EUR): 1980699.31
EU funding (EUR): 1936274.31
Participants: 11
Project status: CLOSED

The overall aim of PROSPECT is to enable peer to peer learning in regional and local authorities in order to finance and implement sustainable energy plans. The learning will empower them to make use of best practices in developing financing for these plans. PROSPECT will address the needs of regional and local authorities through developing a complete peer to peer learning program addressing them. The learning process will be focused on how different sustainable energy projects and measures have been successfully financed. Peer to peer learning involves sharing information and experience from each other through mentoring activities, work shadowing, and study tours, among others. Primarily, the networks Eurocities, Energy Cities and FEDARENE will perform “needs assessment and gaps identifications” with public bodies for learning and match these needs with available best practices. Then PROSPECT will select public authorities and agencies and the roles of trainer and trainees will be assigned. The learning program will be divided into five modules that include development of financing for : i) public buildings, ii) private buildings, iii) public lighting, iv) transport (private and public), and v) cross sectional. The overall estimation is for PROSPECT to launch 5 modules per year (fifteen in total) with an average participation of 15 partners per module. This number can differ depending on the demand there is for each module, but as an average value this can be manageable in terms of teaching requirements. The added value of PROSPECT in comparison to other initiatives is that the learning program is not limited to a capacity building process. Instead, the learning curriculum will follow the project steps of energy efficiency finance from the first stages of its development to monitoring its sustainable operation. The learning program will ideally result to the launch of pilot business models and financing partnerships for implementing sustainable energy plans.

Keywords: peer to peer learning,sustainable energy planning,developing finance,financing tools
Role of non-phagocytic, lymphocyte-like haemocytes in the antiviral and antibacterial defence of shrimp (ShrimpLLH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Shrimp (Penaeus vannamei) aquaculture industry is the fastest-growing sector of the global aquaculture is threatened worldwide by viral diseases, of which White Spot Syndrome is the most harmful and bacterial diseases, of which Vibriosis is the most damaging. Therefore, appropriate biosecurity and management measures in shrimp aquaculture are important in preventing diseases. Stimulating the immunity in shrimp is another factor that can help shrimp in surviving infectious attacks. Although the immune system of invertebrates has been well studied in insects, much less information is currently available for crustaceans. The general concept in a crustacean is that there are three types of haemocytes in the circulating haemolymph, but recent research in the laboratory of Prof. Dr Hans Nauwynck indicated that the haemocytes of P. vannamei can be separated in five distinguished subpopulations, of which two subpopulations were previously not described. The cells of these two subpopulations resemble mammal lymphocytes and are therefore designated lymphocyte-like haemocytes (LLHs). Against this background, it is paramount to investigate the immunological function of these LLHs in depth. ShrimpLLH project objectives are (i) to isolate, (ii) to characterize and (iii) to analyze the immunological functions of haemocyte subpopulations. This project will further fill the knowledge gap in shrimp immunity, more specifically, it will provide information on the immunological role of LLHs. Since this project is multidisciplinary, it will increase the competence of the candidate in advanced immunological techniques and experience in crustacean innate immunity research. The new knowledge gained in this project will facilitate to develop a technique to screen products that can aid the shrimp haemocytes in their fight against different infectious diseases. ShrimpLLH project is in line with the EU strategy for the development of sustainable aquaculture.

Keywords: aquaculture,penaeus vannamei,haemocyte subpopulations,lymphocytes like haemocytes,immune functions
Leveraging the scalability of mobile devices to improve the outcome of all critically ill patients: a multi-faceted health platform to enable the continuum of care from ICU to home. (ConCare)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Estonia
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Intensive Care Units (ICUs), where critically ill patients are cared for by specialized care providers, paradoxically represent a life-threatening environment for 100% of patients: while ICU stay usually lasts <1 week, 90% of ICU survivors show catastrophic, long-term consequences. This happens because dangerous complications are often addressed too late, leading to increased mortality risk. In addition, noise and light levels in Intensive Care Units are too high and induce sleep deprivation: a condition that often leads to delirium. Clinical evidence shows that ICU-acquired co-morbidities should be prevented and addressed by a multi-disciplinary team made of clinicians, families, nurses, therapists. The goal is to deliver seamless patient of care from the first hour in the ICU, up to the discharge in the ward and then at home. Current clinical practice, though, is not able, alone, to deliver an effective and scalable continuum of care. Thanks to years of research and clinical trials, Cognuse developed an IT platform capable of disrupting the patients’ care with comprehensive interfaces for everyone in the care loop. By providing each ICU bed with one tablet, patients, clinicians and families are empowered. The detection of complications is made quick and effective; an automatized system allows to monitor and reduce environmental stressors; families are involved in the care loop and informed; patients themselves are supported and challenged in exercising to recover better. After testing their solution in USA, the Estonian Company Cognuse aims at disrupting now the critical care in Europe. During Phase 1 project the Company will assess software expansion and scale-up plan, will conduct clinical trials for validation and software certification and will establish a sound go-to- market strategy to ensure a swift market uptake of the proposed solution.

Keywords: cloud,health,it platform,healthcare,critical illness,family,patients,continuum of care,recovery,therapy,intensive care,tele rehabilitation,serious games
Magnetic measurement with Absolute Single digit Micron Accuracy (MASMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2021-08-31
Duration (months): 28.0
Total project cost (EUR): 2775000.0
EU funding (EUR): 1942500.0
Participants: 1
Project status: SIGNED

Magnetic specialist BOGEN Electronic GmbH (Germany) is recognized internationally as leading magnetic measurement solution supplier. The company offers highly accurate magnetic incremental encoders and also absolute encoders with medium accuracy. The position measurement and motion control customers are shifting from incremental to absolute measurement principle, but there is no cost-effective highly accurate product available on the market. BOGEN has identified a big market for absolute magnetic measurement with an accuracy between one and better than ten micron and calls this accuracy class single digit micron or short single micron. Potential customers designing robots, machining, printing, metrology products request further reading distances, greater design flexibility, smaller product sizes, easy installation, different protocols for different control architectures from leading PLC companies worldwide. To extend BOGEN's market position to these fast-growing markets, the project objective is to enhance the existing absolute measurement solutions to a Magnetic measurement with Absolute Single Micron Accuracy (MASMA). BOGEN will convert the existing absolute solutions to a modular encoder solution that will detect the position of different absolute scale patterns (e.g. Pseudo random code or Nonius), increase reading distances with a shift to new sensing technology and augment this with smart functions, e.g. using external correction factors. The products will be available at the latest six months past project. Within the scope of this project, BOGEN will furthermore create a chip-based solution for high-volume markets. BOGEN’s innovative, digitally driven scale writing process will enable production of the linear and rotary scales needed with different highly accurate magnetic patterns for absolute scales. Subcontractors will accelerate the switch to new MR technologies and improved scale materials and writing process.

Keywords: accuracy,magnetic,encoder,scale