Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Revolution of sleep diagnostics and personalized health care based on digital diagnostics and therapeutics with health data integration (SLEEP REVOLUTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Estonia,Ireland,Italy,Australia,Italy,Germany,Germany,Italy,Iceland,Germany,Norway,Türkiye,Belgium,Belgium,Finland,Finland,Greece,Greece,Greece,Greece,Croatia,Romania,Sweden,Norway,Belgium,Poland,France,Czechia,Portugal,Portugal,Portugal
Call: Digital diagnostics – developing tools for supporting clinical decisions by integrating various diagnostic data (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 15389965.0
EU funding (EUR): 14998353.75
Participants: 39
Project status: SIGNED

Obstructive sleep apnea (OSA) is associated with various negative health consequences including increased risk of heart disease, hypertension and daytime sleepiness causing road accidents. The economic burden of OSA is rising as almost 1 billion people worldwide are estimated to have OSA. The current diagnostic metric, however, relates poorly to these symptoms and comorbidities. It merely measures the frequency of breathing cessations without assessing OSA severity in any other physiologically relevant way. Furthermore, the clinical methods for analyzing PSG signals are outdated, expensive and laborious. Due to this, the majority of OSA patients remain without diagnosis or have an inaccurate diagnosis leading to sub-optimal treatment. Thus, it is evident that more personalized diagnostics are required including predictive and preventive health care and patient participation. The SLEEP REVOLUTION aims to develop machine learning techniques to better estimate OSA severity and treatment needs to improve health outcomes and quality of life. These techniques are implemented to high-end wearables developed in this project to alleviate the costs and increase the availability of PSGs. Finally, we aim to design a digital platform that functions as a bridge between researchers, patients and healthcare professionals. We will achieve these ambitious goals throughout extensive collaboration between sleep specialists, computer scientists and industry partners. The collaboration network consists of over 30 sleep centers working together to provide the needed retrospective data (over 10.000 sleep studies). The multi-center prospective trials involve experts and end-users to assess and validate the new SLEEP REVOLUTION diagnostic algorithms, wearables and platforms. With the commitment of the European Sleep Research Society and Assembly of National Sleep Societies (over 8000 members), we have the unique possibility to create new standardized guidelines for sleep medicine in the EU.

Keywords: sleep,obstructive sleep apnea,sleep disordered breathing,machine learning techniques,deep learning,artificial intelligence,personalized health care,sleep diagnostics,digital diagnostics
NANO-FIBEROUS CATALYSED FILTERS FOR DIESEL EXHAUST EMISSION CONTROL (NANDEEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-03
End date: 2017-07-02
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Reducing diesel particulate matter (DPM) is a key research area for automotive OEMs in order to meet the more and more stringent emission regulations. Diesel particulate filters (DPF) are used in separation of carbonatious particles by mechanical filtration and subsequent burning of the DPM in order to avoid pressure drop by filter plugging. Since these materials burn at high temperatures (more than 550°C) with oxygen while diesel exhaust gases temperature lies between 200 and 400°C, a suitable catalytic material is required to promote the soot or DPM combustion. Thus, it is very important to develop suitable catalytic materials which are active enough to ignite the DPM at low temperatures. This research proposal is aimed to 1) design and develop a nanofibrous structured catalytic material (Pr2O3 and Mn2O3) using a novel synthesis method to have functions of trapping and combustion of DPM, 2) perform detailed characterisation of the nanofibre catalyst, and 3) demonstrate the emission reduction potential of nanofiber catalyst coated DPF by engine testing. The special morphology of nanofiber structure catalysts will increase the contact point of the DPM and help in burning of the soot. Thus the catalysed DPF can reduce the exhaust particulate emissions and exhaust back pressure there by improving the engine performance as well. These will be demonstrated in running a legislative emission driving cycle on a transient dynamometer engine test facility at the University of Birmingham (UoB). The experienced researcher will bring a new research area in the development of nanofiberous catalyst for DPF to the UoB and the latest advancements in engine testing and emission measurement techniques in the Future Engine and Fuels group will be transferred to the experienced researcher as part of the knowledge transfer. The knowledge generated will be shared among the wide research community and public through various outreach programmes.

Keywords: particulate matter,diesel particulate filter,nano fiberous catalyst,diesel emissions,cold start
Dual targeting of senescence and tumor immunity for cancer therapy (Immune-senescence)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2021-06-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

We have previously demonstrated that cellular senescence opposes tumorigenesis thereby opening up new potential opportunities for cancer treatment. Senescence and tumor immunity in cancer are tightly interconnected. Tumor-infiltrating immune cells promote the clearance of senescent tumor cells thereby contributing to the tumor suppressive function of senescence. Moreover, T lymphocytes can drive senescence in cancers by secreting different cytokines in the tumor microenvironment. We have also recently reported that GR1+ myeloid cells antagonize treatment-induced senescence (TIS) and that compounds that block the tumor recruitment of GR1+ cells enhance TIS. Major objective of this proposal is to characterize the immune landscape of different prostate cancer mouse models in order to develop novel treatment modalities that combine pro-senescence compounds with immunotherapy. Using proteomics and bioinformatics approaches, we will assess how the genetic background of prostate tumors, shapes the tumor microenvironment and immune response during TIS. Next, we will define the mechanisms that regulate the recruitment and activation of myeloid derived suppressive cells, macrophages and B-lymphocytes in Pten deficient prostate tumors by focusing on a novel class of secreted factors identified in these tumors. We will also assess in vivo whether the secretome of tumor cells can transmit senescence to TILs and compounds that interfere with the secretome can prevent immunosenescence. Finally, we will develop monoclonal antibodies directed towards senescent tumors cells that we will use as diagnostic and therapeutic tools. These antibodies will be used as biomarkers to detect senescent tumor cells in prostate cancers and will be tested in pre-clinical trials to assess whether they improve tumor clearance during TIS. Our findings will form the basis for future clinical trials in prostate cancer patients.

Keywords: cancer immunology
European Digital Forum Thought Leadership and Policy Network Exchange (EDFx)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Coordination and support actions
Countries involved: Spain,Belgium,United Kingdom
Call: Web Entrepreneurship (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 675098.75
EU funding (EUR): 675098.75
Participants: 3
Project status: CLOSED

The European Digital Forum (EDF) is a think tank led by the Lisbon Council and Nesta (secretariat). It was first proposed in the Startup Manifesto and later launched by European Commission Vice-President Kroes at the World Economic Forum in Davos in January 2014. Its founding partners are European Investment Fund, Telefonica, BBVA and Orange. They provided seed funding to get the EDF off the ground but the financial resources are insufficient to execute the ambitious work programme envisioned by the secretariat. The objectives of the EDF Thought Leadership and Policy Network Exchange (EDFx) are: 1) To scale up existing activities of the EDF, enabling greater policy impact and geographical reach 2) To pursue independent research aimed at highlighting ways to measure and improve the framework conditions for web entrepreneurs 3) To facilitate a deeper, more sustained exchange between the web community and policymakers, thereby informing and shaping public policy The objectives will be achieved through high-level policy summits and fringe events at established tech fora; the development of a one-of-its-kind indicator to measure the quality of the startup ecosystem and a repository of best practices, as well as a hard-hitting communication and community-building strategy, including policy support and monitoring actions. EDFx will operate at the intersection of web entrepreneurship (i.e. founders, investors) and public policy (i.e. politicians, civil servants), exploiting synergies between the two groups and engaging them in a future-oriented exchange. This dialogue will be placed squarely in a broader policy setting - underlining the significance of web entrepreneurship to innovation performance, growth and job creation - and will be underpinned by a dynamic, world-class research and outreach programme. The fact that EDFx will build on a successful project that is already underway will allow it to “hit the ground running” to achieve speedy impact and results.

Keywords: technology,entrepreneurship,digital,policy,innovation,growth,jobs
Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes. (ElectroPheX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2024-07-31
Duration (months): 36.0
Total project cost (EUR): 246669.12
EU funding (EUR): 246669.12
Participants: 2
Project status: SIGNED

ElectroPheX aims to develop electrochemically-mediated methods for the site-selective halogenation of phenols. Electrochemistry will be the main feature of this project as it can be an efficient way to access and manipulate reactive intermediates. The project will span disciplines (interdisciplinarity) and aims to study electrochemistry’s ability to act as an enhancement tool for both selectivity and reactivity. Electrochemistry will help us to: (1) help us study the redox properties of catalysts, compounds, complexes and substrates (find redox potentials etc.); (2) to generate open-shell species; and, (3) to adjust the oxidation state of metals. WP1-ORTHO focuses on (1) the design and synthesis of a series of compounds that contain N-halogen bond and they are capable of facilitating the ortho-halogenation of phenols upon anodic oxidation, (2) the study of intermolecular interactions and how the electrochemical generation of the corresponding radical-cation of N-halogen bond will alter/enhance the strength of the former. WP2-META aims at the development of an electrochemically-mediated methodology for the meta-halogenation of phenols. Early transition metals (Mn, Co) will be used in order to facilitate the desired transformation. Electrochemistry will orchestrate the whole procedure giving access to adjacent oxidation states of metallic centers. WP3-PARA targets para-halogenation of phenols mediated by a novel catalyst that mimics a main feature of photosystem II leading to a proton-coupled electron transfer (PCET) protocol for the transformation. In WP4 the acquired knowledge will be translated to complex phenolic compounds in order to achieve a late-stage functionalization. SAR libraries, PET radiotracer, Also, the synthesis of highly site-selective halogenation of phenols can provide valuable intermediates for the preparation of poly-substituted arenes with a well-defined relationship between their substituent via cross-coupling reactions.

Keywords: electrochemical mediated reactions
Control of Triboelectricity from Micro to Macro as a Principle of Sticking, Particulate Contamination and ESD Prevention of Micromachines (Tribocharge)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Türkiye
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 157845.6
EU funding (EUR): 157845.6
Participants: 1
Project status: CLOSED

Microelectromechanical systems (MEMS) is the technology of micromachines up to 100 micrometers in size. In the era of minituarization, MEMS represents a huge and rapidly growing market, which will exceed $20B by 2020 and Europa constitutes about 20% of the total world market. However, the technology struggles with some problems preventing its fast development. This proposal aims to deal with those related to tribocharging (frictional electricity), which has been overlooked so far. Tribocharging is a very common event causing value losses due to electrostatic sticking and electrostatic discharging (ESD) problems in many industrial manufacturing processes such as static cling of powder materials in drug processing, ESD problems in electronics. Attempts to eliminate static electricity from solid and liquid materials includes the addition of antistatic agents to them that increases the deposition of water from ambient moisture and the addition or doping of some conducting materials e.g. carbon powder into plastics and a conductive path removes the excess electrostatic charge. However, these solutions are not generally very practical and limited by the specific applications in micro dimensions. In this proposal, we focused on the elimination of static charge that accumulates on MEMS. To eliminate static electricity from MEMS, I will use the chemical approach that we introduced (Science, 2013). Firstly, we aim to eliminate the excess static charge from polymer based (MEMS) using this approach by incorporating antistatic and anti-sticking properties to these micro devices for the first time. Secondly, ESD will be eliminated in these micro devices using the same approach based on the scavenging of excess electrostatic charges. Finally, it will be possible to extend the lifetime of these micro devices by eliminating problems such as sticking, (charged) particulate contamination due to e.g. wear, and ESD that mainly arise from tribocharging.

Keywords: tribocharge,mems,surface chemistry,stiction
Are social skills determined by early live experiences? (ApeAttachment)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-09-30
Duration (months): 66.0
Total project cost (EUR): 1495000.0
EU funding (EUR): 1495000.0
Participants: 1
Project status: CLOSED

Social bonding success in life impacts on health, survival and fitness. It is proposed that early and later social experience as well as heritable factors determine social bonding abilities in adulthood, although the relative influence of each is unclear. In humans, the resulting uncertainty likely impedes psychological and psychiatric assessment and therapy. One problem hampering progress for human studies is that social bonding success is hard to objectively quantify, particularly in adults. I propose to directly address this problem by determining the key influences on social bonding abilities in chimpanzees, our closest living relative, where social bonding success can be objectively quantified, and is defined as number of affiliative relationships maintained over time with high rates of affiliation. Objectives. This project will quantify the relative impact of early and later social experience as well as heritable factors on social hormone levels, social cognition and social bonding success in 270 wild and captive chimpanzees, using both cohort and longitudinal data. This will reveal the degree of plasticity in social cognition and bonding behaviour throughout life. Finally, it will evaluate the potential for using endogenous hormone levels as non-invasive biomarkers of social bonding success, as well as identifying social contexts that act as strong natural social hormone releasers. Outcomes. This project will expose what makes some better at social bonding than others. Specifically, it will show the extent to which later social experience can compensate for early social experience or heritable factors in terms of adult social bonding success, the latter being a key factor in determining health and happiness in life. This project also offers the potential for using hormonal biomarkers in clincial settings, as objective assessment of changes in relationships over time, and in therapy by engaging in social behaviours that act as strong social hormone releasers.

Keywords: early attachment,adult attachment,oxytocin,mentalizing,pragmatic communication,social bonds,chimpanzees
Eastern Mediterranean and Middle East – Climate and Atmosphere Research Centre (EMME-CARE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Cyprus,Finland,France
Call: Teaming Phase 2 (H2020-WIDESPREAD-2018-01, 2018)
Start date: 2019-09-01
End date: 2026-08-31
Duration (months): 84.0
Total project cost (EUR): 14944913.75
EU funding (EUR): 14944913.75
Participants: 4
Project status: SIGNED

The Cyprus Institute (CyI) is a science and technology research and postgraduate education organization. In the past decade, it has become a national competence centre in atmospheric and climate research. We propose the Eastern Mediterranean and Middle East – Climate and Atmosphere REsearch (EMME-CARE) project, to upgrade the Atmosphere and Climate Division of CyI into a Centre of Excellence (CoE) with a regional focus. Cyprus is strategically located in the EMME at the intersection between Asia, Africa and Europe, providing an invaluable link between Europe and the Middle East. The region faces many challenges, such as rapid population growth, as well as political and socio-economic instabilities. These challenges, experienced by a part of the world that is already hot and arid, are exacerbated by droughts and extreme weather conditions associated with rapid climate change. Temperature extremes, in combination with increasing air pollution and windblown desert dust, could lead to intolerable conditions in both urban and rural environments, ultimately compromising human habitability and promoting migration. EMME-CARE proposes a comprehensive and integrated programme to address these challenges through an exceptional combination of research, innovation and education, focussing on Cyprus and the EMME. This involves experimental research and data-informed computer modelling of the regional atmospheric environment and climate change impacts. The advanced partners in the project provide world-leading expertise in atmospheric and climate research, at a fundamental level, low carbon technologies and innovation, along with advanced graduate education and experience with major European research infrastructure. The Coe aims at solutions for society, including the public health, agriculture and energy sectors. EMME-CARE will create a CoE that acts as a knowledge hub for critical issues related to environmental and climate change, serving Cyprus and the region.

Keywords: air quality and pollution,climate change impacts,instrumentation,environmental monitoring platforms,atmosphere and climate models,greenhouse gases,environmental health,mediterranean