Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultra-versatile Nanoparticle Integration into Organized Nanoclusters (UNION)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Ireland,Germany,Spain,Hungary,France,Italy,United Kingdom
Call:  (FP7-NMP-2012-SMALL-6, 2012)
Start date: 2013-02-01
End date: 2016-01-31
Duration (months): 36.0
Total project cost (EUR): 5179604.58
EU funding (EUR): 3798053.0
Participants: 9
Project status: CLOSED

UNION will develop nanoparticle (NP) assembly techniques, and assembly monitoring technologies to prepare novel hierarchically-ordered nanoparticle clusters (NPCs). By improving control over the synthesis and assembly of NPs we will produce materials with tailored and predictable properties. Furthermore, by incorporating hierarchical control into the assembly (through the type, size and spatial distribution of the NPs) it will be possible to assess the influence of the hierarchy on properties and develop new functionalities. UNION will investigate how the emergent properties of the assemblies are determined by the architecture of the assembly, the extent of order, and the properties of the component NPs. This will enable tuning of the primary NP properties and the assembly processes to develop significant breakthroughs in nano-devices and next generation complex nanotechnology products. As the ultimate aim is commercial exploitation of our results, in each stage of the development process we will use application driven, scalable and cost-effective processes, incorporating EHS assessment and roadmap preparation towards future industrial deployment. UNION will achieve its objectives through a three stage approach. - Improved NP preparation providing optimised surface chemistry for subsequent assembly - Novel NPC formation (hierarchical nanoparticle assembly) methods - Roll-out of NPCs for three application areas NPC applications will be developed within three core areas corresponding to the different hierarchical structural levels; in suspensions of individual NPCs (biomedical), in supported 2D NPC arrays (optical), and in 3D arrays or nanocomposites (thermoelectric). Our consortium is comprised of multidisciplinary research groups involving 8 partners with ex-pertise in preparation and application of nano-materials. It includes significant industrial participation with 4 companies with specific knowledge and testing capability for the target application areas.

Keywords: nanoparticle assembly,hierarchical control,nanocomposites,bio-,optical & thermoelectric applications,predictable properties,functionality,scalability
Development of recovery processes for recycling of valuable components from FPDs (In, Y, Nd) for the production of high added value NPs (RECYVAL-NANO)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Spain,Netherlands,United Kingdom,Sweden,Netherlands,Netherlands,Spain,Ireland
Call:  (FP7-NMP-2012-SME-6, 2012)
Start date: 2012-12-01
End date: 2016-11-30
Duration (months): 48.0
Total project cost (EUR): 4395750.84
EU funding (EUR): 3127813.72
Participants: 12
Project status: CLOSED

Waste Electrical and Electronic Equipment is considered to increase drastically in the coming decades. WEEE contains considerable quantities of valuable components used in high-tech applications that currently are not recycled. Europe needs to improve and develop Recovery, Recycling and Reuse of critical materials in order to avoid the dependency on imports, high prices and risk of supply imposed by countries owning mineral reserves. RECYVAL-NANO project will develop an innovative recycling process for recovery and reuse of indium, yttrium and neodymium metals from Flat Panels Displays (FPD), one of the most growing waste sources. The project will be addressed not only to the recovery of these critical elements, but also the recycling process developed will result in the direct extraction of metallorganic precursors for direct reuse in the production of high added value nanoparticles that is ITO, Y2O3:Eu3+ and Nd-Fe-B. The project will develop an integral study of the recycling process, starting with logistic issues of the waste collection, optimising mechanical sorting technologies and developing innovative ones for the recovery and concentration of smaller fractions containing indium, yttrium and neodymium, developing simplified solvent extraction routes based on tailored chemical extraction agents able to extract a 95 % of the key metal in a metallorganic extracted solutions, and using these extracted solutions as precursors in the direct production of advanced nanoparticles. RECYVAL-NANO will validate the recycling process developed through the construction, optimisation and demonstration of full pilot lines for mechanical recycling of FPDs (500 kg/h) and hydrometallurgical metal recovery processes (500 g/h). Finally, the demonstration of the superior performance application of ITO, Y2O3:Eu3+ and Nd-Fe-B nanoparticles in electronic applications of transparent conductors, LEDs and permanent magnets respectively will complete the entire cycle of the project.

Keywords: weee,fpd,recycling,nanoparticle,metallorganic,ito,y2o3:eu+3,nd-fe-b,indium,neodymium,yttrium.
Cytosine-5 methylated RNAs as stem cell regulators in normal tissues and diseases (M5C RNA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: United Kingdom
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-02-01
End date: 2019-01-31
Duration (months): 72.0
Total project cost (EUR): 1441945.4
EU funding (EUR): 1441945.4
Participants: 1
Project status: CLOSED

Stem cells differentiate into all mammalian tissues and organs during development, and remain present to maintain and replenish tissues throughout life. Stem cells continuously maintain their population (self-renewal) while generating progeny (differentiation). During self-renewal stem cells have to avoid cell cycle exit and differentiation; whereas during differentiation stem cells must evade uncontrolled proliferation. Dissecting the regulatory pathways controlling the balance between these two states is fundamental to understanding how stem cell mis-regulation causes human diseases. Although transcriptional regulation of stem cells is increasingly understood, virtually nothing is known about how post-transcriptional mechanisms can influence stem cell maintenance. Post-transcriptional modifications are commonly found in non-coding RNA species, yet the biological function is unknown. My previous studies identified cytosine-5 methylation (m5C) of RNA as a novel mechanism regulating stem cell fate. m5C is a widespread modification in both DNA and RNAs and their methyltransferases share many structural features. Whereas the functions of m5C in DNA have been extensively studied, the cellular and molecular functions of the same modified nucleobase in RNA remain unclear. Using a combination of system-wide approaches, mouse models and in vitro differentiation assays, we propose to (1) globally identify m5C in RNA species; (2) functionally analyze the roles of methylated versus non-methylated RNAs in stem cells; and (3) determine how aberrant m5C modifications can cause intellectual disability disorders in humans. Our comprehensive approach will answer how post-transcriptional modification control stem cell fate in normal tissues and might lead to the discovery of novel therapeutic strategies for neurological disorders in humans.

Keywords: post-transcriptional modifications,cytosine-5 rna methylation,rna methyltransferases,stem cell differentiation
Brain-gut interactions in Drosophila melanogaster (BRAINGUTTALK)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: United Kingdom
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-02-01
End date: 2018-01-31
Duration (months): 60.0
Total project cost (EUR): 1499740.0
EU funding (EUR): 1499740.0
Participants: 1
Project status: CLOSED

The gastrointestinal tract is emerging as a key regulator of appetite and metabolism, but studies aimed at identifying the signals involved are faced with daunting neuroanatomical complexity: there are as many as 500 million neurons in the human gut. Drosophila should provide a simple and genetically amenable alternative, but both its autonomic nervous system and the signalling significance of its digestive tract have remained largely unexplored. My research programme will characterize the signals and neurons mediating the interaction between the nervous and digestive systems, and will establish their significance both in the maintenance of metabolic homeostasis and in response to nutritional challenges. To achieve these goals, we will capitalize on a multi-disciplinary approach that combines the genetic manipulation of defined neuronal lineages, a cell-biological approach to the study of enterocyte metabolism, and our recently developed physiological and behavioural readouts. Our work will provide new insights into the signals and mechanisms modulating internal metabolism and food intake: processes which, when deregulated, contribute to increasingly prevalent conditions such as diabetes, metabolic syndrome and obesity. Our recent finding of conserved mechanisms of autonomic control in the fruit fly makes us confident that the signals we identify will be relevant to mammalian systems.

Keywords: drosophila,intestine,enteric nervous system,enterocyte,nutrition,diabetes,obesity,metabolic syndrome
The in vivo roles of tRNA modification (TRNAMODI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2012-12-01
End date: 2017-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

tRNA molecules are key in translating the genetic information into a protein sequence and critical for all aspects of cellular metabolism. Interestingly, tRNAs carry a plethora of chemical modifications, thought to regulate their function. Many of these modifications are evolutionarily highly conserved, and some linked to human degenerative diseases and cancer. However, we know little about their in vivo function and the mechanisms of how aberrations in tRNA modification lead to cellular phenotypes. Thus, my proposal aims at gaining mechanistic insights into the in vivo function of tRNA modifications by performing a comprehensive systems analysis of tRNA modification pathways in yeast: First, I will identify transcripts, which are abnormally translated in tRNA modification mutants, thus causing the observed phenotypes. Importantly, I will define the codon signatures that are the underlying cause. Second, I will develop a mass spectrometric LC-MS/MS-based workflow, allowing for a quantitative and sequence specific analysis of RNA modifications, which is currently not done in Europe. Third, by combining population analyses and long-term evolution experiments, I will address how tRNA modifications constrain the evolution of genomes and modulate cellular stress responses. To achieve my goals, I will combine novel technologies and genetics in an unprecedented manner to push the limits of our understanding. I will employ ribosome profiling, a novel method, that provides high-resolution snapshots of the translatome. I will use quantitative RNA mass spectrometry to establish the link between tRNA modification and changes in translation. Finally, I will use quantitative protein mass spectrometry to verify the translation effects of tRNA hypomodification at the proteome level. Taken together, my project will for the first time unbiasedly link tRNA modifications and translation in vivo by a systems approach and provide an important service to the European RNA community.

Keywords: trna modification,translation,ribosome profiling,rna mass spectrometry,budding yeast,s. cerevisiae,translatomics,genetic screens,quantitative mass spectrometry
New cost/effective superHYDROphobic coatings with enhanced BOND strengh and wear resistance for application in large wind turbine blades. (HYDROBOND)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Spain,Finland,Germany,Italy,Finland,Denmark
Call:  (FP7-NMP-2012-SMALL-6, 2012)
Start date: 2013-01-01
End date: 2016-12-31
Duration (months): 48.0
Total project cost (EUR): 4201298.45
EU funding (EUR): 2929476.0
Participants: 8
Project status: CLOSED

The main objective of HYDROBOND is the development of a highly innovative process for application of superhydrophobic coatings onto large off-shore turbine blades, that will contribute to minimize the power losses and mechanical failures. Novel thermal spray technologies will be the way to achieve the nanostructured coatings with tailored anti-icing properties and enhanced bond strengh, in a cost effective manner for very large, composite material surface. The pursued scientific-technological objectives and impacts derived from HYDROBOND project are - Based on the properties of the new coatings, that will act as a passive anti-icing method, allow the design and construction of lighter larger wind turbines, avoiding the needs of heavier active anti-icing methods. - Due to the anti-icing properties, new coatings will allow the minimization of the ice accretion and will increase the reliability and operational life of components by reducing the mechanical failures. As already stated in this proposal, ice accretion will increase the load on the blades and on the tower structure, causing high amplitude vibrations and/or resonance as well as mass imbalance between blades, affecting specially the gearboxes whose lifetime is considerably reduced. - New anti-icing coatings will improve the cost/efficiency ratio of the blades, because ice accretion changes the shape and roughness of the blade airfoil significantly reducing aerodynamic properties of the blade resulting in power losses. - Due to the enhanced bond strengh and the ability to keep the anti-icing properties even when wear phenomena happens, will contribute on reducing the maintenance needs. The new developed process, being a portable one, will also contribute to reduce the maintenance cost of off-shore wind turbines allowing in situ repair.

Keywords: nanostructured coatings,anti-icing coating,superhydrophobic coating,large wind turbine blades,cold spray,liquid flame spray
Frontiers of Oxidative Protein Folding and Assembly: Catalysis of Disulfide Formation Downstream of the Endoplasmic Reticulum (QSOX1BIOFUNC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Israel
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2012-12-01
End date: 2017-11-30
Duration (months): 60.0
Total project cost (EUR): 1498083.0
EU funding (EUR): 1498083.0
Participants: 1
Project status: CLOSED

Quiescin sulfhydryl oxidase (QSOX), which catalyzes disulfide cross-linking in proteins, is up-regulated in many tumor types. QSOX is the only disulfide catalyst to undergo regulated secretion from cells, but the biological role of the enzyme, its substrates, and its mechanistic link to cancer are obscure. In addition to determining the first X-ray crystal structures of QSOXs, we recently discovered that QSOX is required for incorporation of laminins into basement membrane extracellular matrix (ECM). Fibroblasts depleted of QSOX make defective ECM that fails to support adherence and migration of tumor-derived cells in co-culture, but ECM composition and cell migration are restored by supplying recombinant QSOX exogenously. Our observations suggest a role for QSOX in building a microenvironment favorable for tumor cell survival and migration. We are motivated by a number of observations to expand our studies of QSOX enzymes. First, QSOX is ideally suited for single-molecule fluorescence resonance energy transfer experiments, which will shed light on hitherto invisible steps in the QSOX reaction cycle. Second, we have evidence for additional functions of QSOX with intriguing links to lipid metabolism and lipid storage diseases, and we are compelled to discover the pathways involved. Third, the modulation of tumor/stromal interactions is a promising direction for anti-metastatic cancer therapy, so the QSOX inhibitors we are developing may find use in the clinic as well as in the laboratory. Fourth, the complex QSOX expression patterns in developing and adult mammals prompted us to generate a conditional QSOX knockout mouse with which to explore QSOX function in vivo. In consolidating my laboratory, I will continue to rely heavily on my strengths as a structural biologist while pushing forward the frontier of our understanding of oxidative protein folding and assembly in cell and matrix biology, a fascinating subject that spans the Angstrom to the organism.

Keywords: disulfide bond formation,golgi,protein assembly,protein conformational changes,tumor/stromal interactions,laminin,monoclonal antibodies,enzyme substrate identification
Development of a general-purpose deep ocean float (MULTIMERMAID)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: France
Call:  (ERC-2011-PoC, 2011)
Start date: 2012-04-01
End date: 2013-09-30
Duration (months): 18.0
Total project cost (EUR): 162496.8
EU funding (EUR): 149800.0
Participants: 1
Project status: CLOSED

We propose to develop an autonomous float that can dive much deeper than existing floats (5000 m instead of 2000 m), carry four times more battery capacity, and perform multiple observations at the same time. The project combines the expertise gained in the development of a floating seismometer as part of the ERC/GLOBALSEIS project with the know-how on building ocean bottom seismometers available at our laboratory Geoazur. It also capitalizes on our collaboration with oceanographers using floats for biophysical observation (project ERC/remOCEAN) and with OSEAN, with whom we developed a multi-purpose electronic card that can collect and transmit multichannel observations using commercially available floats. The resulting instrument will be useful for scientific, military and civilian applications, ranging from seismology to the detection of the "black box" signals emitted by an airplane that has gone down at sea.

Keywords: 226837
Investigating the therapeutic potential of manipulating the IGF-IGFBP1 axis in the prevention and treatment of cardiovascular disease, diabetes and obesity. (BP-CARDIO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: United Kingdom
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-01-01
End date: 2017-12-31
Duration (months): 60.0
Total project cost (EUR): 1493543.0
EU funding (EUR): 1493543.0
Participants: 1
Project status: CLOSED

More than 30 million people are living with diabetes in the EU, with a prevalence expected to grow to over 10% of the adult population by the year 2030. Type 2 diabetes is a major cause of cardiovascular disease related death and disability, substantially increasing the risk of myocardial infarction, stroke and peripheral arterial disease. Recent landmark trials, showing that intensive glucose control does not improve cardiovascular outcomes and may increase mortality in some circumstances, provide a compelling rationale for intense research aimed at developing novel therapeutic strategies. Type 2 diabetes is underpinned by resistance to the effects of insulin, which I have shown in endothelial cells causes reduced bioavailability of the anti-atherosclerotic molecule nitric oxide and leads to accelerated atherosclerosis. The cellular effects of insulin are mirrored by insulin-like growth factor factor-1, the bioavailability of which at its receptor is in turn is regulated by a family of high affinity binding proteins (IGFBP). Epidemiological studies demonstrate and inverse association between one of these binding proteins, IGFBP1, and diabetes-related cardiovascular risk. I have recently demonstrated that IGFBP1 when expressed in mice can ameliorate insulin resistance, obesity and atherosclerosis. In endothelial cells, I showed that IGFBP1 upregulates the production of nitric oxide indepenedently of IGF. These findings suggest that IGFBP1 may be a ‘protective’ endogenous protein and that increasing circulating levels may be a therapeutic strategy to prevent development of diabetes and cardiovascular disease. In this proposal I will address this hypothesis by employing state of the art studies in cells and novel gene modified mice to unravel the molecular basis of the protective effects of IGFBP1 and to investigate the possibility of exploiting the IGF-IGFBP axis to prevent cardiovascular disease in the setting of diabetes and obesity.

Keywords: obesity,diabetes,insulin resistance,nitric oxide,endothelium,atherosclerosis