Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improving diagnostics of respiratory diseases and boosting the COMAC MEDICAL Ltd. competitiveness and growth by validation of fractional EBT biomarker through new method of measurement and device (FrEBT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Bulgaria
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2015-10-31
Duration (months): 2.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The innovation project objectives are to: 1/prove through a feasibility study the potential to validate the Fractional Exhaled Breath Temperature, via new viable and disruptive technological device, as a diagnostic, prognostic and monitoring biomarker for inflammatory and obstructive pulmonary diseases; 2/enhance the competitiveness and profitability of the full- service clinical research organization COMAC MEDICAL Ltd., operating via own network of partners in 14 countries from 3 European regions with population of over 118 mln. The commercial potential of the innovative solution is that it is a best alternative of the existing methods on market, saving great number of diagnosis‘ stages without any potential risk for the patients, being more precise, user friendly, non-invasive, less painful, faster, cost effective, covering vulnerable groups of children, young and elderly people, saving lives, increasing workforce capabilities. It is a response to the EU wide and global challenges related to the respiratory diseases causing high level of morbidity and mortality–at about 1 million deaths annually in the European Region; 2/3 of them in EU28, with total cost there of € 380 bln. The expected SME growth is 20%, leading to specialisation in Pulmonology and Oncology and filling a market niche. The SME will launch into new markets in Europe and Asia, increasing its market share in clinical trials - 12-15% in Bulgaria;10% in Europe and 2-5% worldwide. The outcome of the Phase1 project is a feasibility study, assessing the socio-economic, commercial, technical aspects of the innovation, based on 6 steps of activities on: the Description of the innovative solution;Market/Technical Feasibility;Financial/Economic Feasibility; Organizational/Managerial Feasibility;Risk assessment;IP Management. The targeted users are the patients through the healthcare systems and the doctors, specialists in respiratory diseases and lung cancer as well as the GPs.

Keywords: fractional ebt,respiratory diseases,diagnostic and prognostic biomarker,competiveness,diagnostic device,market specialization,citizens healthcare,societal challenges,clinical trials,trl7
Personal Energy Administration Kiosk application: an ICT-ecosystem for Energy Savings through Behavioural Change, Flexible Tariffs and Fun (PEAKapp)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Austria,Germany,Estonia,Türkiye,Netherlands,Denmark
Call: New ICT-based solutions for energy efficiency (H2020-EE-2015-2-RIA, 2015)
Start date: 2016-03-01
End date: 2019-06-30
Duration (months): 40.0
Total project cost (EUR): 1938085.0
EU funding (EUR): 1938085.0
Participants: 13
Project status: CLOSED

PEAKapp targets the development of an unprecedented ICT-to- Human ecosystem to trigger lasting energy savings through behavioural change and continuous engagement, to enable increased consumption of clean and low-priced electricity from the spot market for household customers, to connect them to social networks, to motivate them through serious gaming, and to boost the efficacy of Smart Home building energy management systems by integrating their functionalities into the PEAKapp solution. With this first close-to-market-ready attempt to provide households with a dynamic electricity tariff in the EU, the door is opened for the most significant impact on the household electricity market since its liberalisation. The ICT ecosystem will be designed to require smart meters as only hardware with respect to in-house equipment, such that the system can be implemented almost immediately, given the EU targets for smart meter roll-out. These low hardware requirements allow for a fast market uptake, and thus a noticeable impact on EU energy consumption can be experienced with almost no delay and without the need of having to equip the 230mio dwellings in the EU with any extra efficiency hardware. Validation of the ICT ecosystem under real life conditions in the publicly owned social housing sector will be carried out in Austria, Estonia, Sweden and Latvia, and analyses of the collected data will allow for ground-breaking insights into consumer behaviour, while outstanding EU energy market analyses will derive implications for regulatory practice to better support energy efficiency goals. An outstanding market uptake strategy makes >3 electricity utilities ready-to-sign the implementation of the ICT-system, advises the European social housing sector about its benefits, and fosters European and international market uptake by distinguished exploitation activities, where the leading US stakeholder EPRI takes responsibility without funding.

Keywords: social metering,serious gaming,dynamic electricity prices,social housing,social networking
A New Drive-by-Wire Technology for People with Disabilities and Industrial Applications (Joysteer 3.0)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Switzerland
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

People with physical disabilities require adaptable systems to provide them with new reliable and easy to operate driving solutions, as they cannot drive using conventional car controls. They need an adaptation of standard production cars, which allows them to drive just as safe as a non-disabled driver. Current car adaptation solutions are enabled by drive-by-wire technologies, which consist of man-machine-interfaces (MMIs) and electronic driving systems used to compensate disabilities. With this technology, the driver does not have to use conventional controls such as the steering wheel, instead, driving is facilitated by individually adapted MMIs like joysticks or handlebars. However, current adaptive devices are unable to match the performance of conventional controls. There can be technical problems as time lags between the execution of a control command -e.g. steering- and the actual vehicle reaction, interference between command actions -e.g. steering and gas-, etc. The car usually does not react according to the driver’s expectations, so that learning to drive an adapted car is difficult and requires a long time. Overcoming these issues, joysteer3.0 is a novel drive-by-wire system offering the best drivability, safety and reliability standards for steer, brake and gas, allowing people with a wide range of disabilities the operation of a car. Its high modularity together with its new remote GPS-based capabilities address a new market segment for safety-critical industrial applications. Our business model will subsequently benefit from new revenue streams and our cost structure will be drastically improved. We have estimated that the successful accomplishment of this project will lead to an accumulated profit of €5.25M for the first 3 years of commercialization, which gives a ROI2021→2023=2.09. With an initial investment of €1.7M to bring joysteer3.0 to the market we forecast a payback time of 21 months.

Keywords: drive by wire,x by wire,steer by wire,brake by wire,throttle by wire,handicap driving,vehicle adaptation,unmanned driving
Geodetic Integrated Monitoring System (GIMS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Italy,Slovenia,Switzerland
Call: EGNSS professional applications (H2020-GALILEO-GSA-2017-1, 2017)
Start date: 2017-11-01
End date: 2021-01-31
Duration (months): 39.0
Total project cost (EUR): 2217081.25
EU funding (EUR): 1714237.38
Participants: 6
Project status: CLOSED

The main objective of the GIMS project is to build and commercialize an advanced low-cost system based on EGNSS, Copernicus SAR and other in-situ sensors, like inertial measurement units, for the purpose of monitoring ground deformations with a focus on landslides and subsidence. The system will recover deformations with millimetric level accuracies and daily acquisition rate. Moreover the integration of in-situ accelerometers will give real-time alerts in case of sudden movements. Finally the low-cost infrastructure deployed for the landslide monitoring can be used as collector of environmental data for smart grids purposes. The observations of these three different monitoring techniques, namely EGNSS, SAR and accelerometers, are complementary in time and space and can be integrated to obtain a better understanding of the monitored processes and a more complete knowledge of the deformation phenomenon. The project involves researchers and industrial developers from different fields: radiofrequency analysis and related hardware design, telecommunications, SAR and GNSS data analysis, accelerometers signal processing, geostatistics, geology. Significant effort will be put in the cooperation between different areas and in the interface between different products and technologies. The overall purpose of the GIMS project is to have detailed and timely knowledge of the geophysical behaviour of parts of the Earth surface, and its hindrances on structures, in order to mitigate casualties and injuries to the population, and better plan maintenance intervention.

Keywords: copernicus sentinel 1 insar,mems inertial measurement units,landslide monitoring,subsidence and uplift monitoring,new product,new service
Immunological synapse derived ectosomes in T cell effector function (SYNECT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2021-04-30
Duration (months): 66.0
Total project cost (EUR): 2212114.0
EU funding (EUR): 2212114.0
Participants: 1
Project status: CLOSED

The immunological synapse is a highly conserved scaffold for communication between immune cells built around cooperation of antigen and adhesion receptors. It often takes the form of a bull’s eye with a central cluster of antigen receptors surrounded by a ring of adhesion molecules. We have recently observed that antigen receptor coated extracellular microvesicles bud directly from the center of the immunological synapse- which we define as synaptic ectosomes. Synaptic ectosomes are transferred to the antigen- presenting cell and can generate signals after the T cell-APC synapse has dissolved. We aim to determine the composition of synaptic ectosomes, determine their fate in the antigen-presenting cell and identify approaches to manipulate their formation in vivo. The objectives will be to 1) isolate synaptic ectosomes from human T cells and determine their molecular composition; 2) determine the functional impact of synaptic ectosomes on the antigen presenting cell; and 3) use gene targeting to control the process in vivo to understand its role in T function of helper, cytotoxic and regulatory T cells. The technologies will include microscopy, proteomics, genomics, and in vivo models with constitutive and conditional gene targeting. This work will address fundamental gaps in our understanding of immune cell communication.

Keywords: immunological synapse,adhesion,microscopy
DNA end protection in Immunity and Cancer (DNAendProtection)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2021-06-30
Duration (months): 70.0
Total project cost (EUR): 1993421.0
EU funding (EUR): 1993421.0
Participants: 1
Project status: CLOSED

This proposal addresses a fundamental issue in molecular biology: how is repair of DNA double-strand breaks (DSBs) steered towards the appropriate physiological outcome? DSBs are cytotoxic DNA lesions that arise as a by-product of DNA replication, but also as a physiological intermediate during antigen receptor diversification in the Immune system. DNA end processing is a major determinant of DSB repair outcome. Resection of DNA ends is a prerequisite for physiological repair of replication-associated breaks by homologous recombination, but detrimental for productive end-joining events during immunoglobulin class switch recombination (CSR) in B lymphocytes. Furthermore, inappropriate resection of DSBs can cause loss of genetic information and chromosome deletions, which are common features of cancer genomes. The mechanisms that regulate the balance between DNA end resection and protection are poorly understood. Here, I propose to study the molecular machinery that mediates protection of DNA ends in primary B cells, and the end resection-promoting factors that are antagonized by this activity. We and others have shown that the DNA repair factor 53BP1 plays a crucial role in protecting DNA ends against resection, and consistent with this function, 53BP1 is essential for CSR, but also responsible for aberrant repair of replication-associated DNA damage. In Aims 1 and 2, we will test the hypothesis that dynamic interactions between multiple 53BP1 effectors mediate protection of DNA ends against resection. In Aim 3, we will define the landscape of end resection-promoting factors in mammalian cells via a high-throughput RNAi screen for rescue of CSR in 53BP1-deficient B cells. By elucidating the molecular mechanisms underlying DSB end processing in B lymphocytes, these studies will significantly advance our understanding of the molecular basis of immunodeficiencies and cancer predisposition in lymphoma and solid tumors.

Keywords: dna double strand breaks,dna resection,53bp1 dna end protection function,b lymphocytes,class switch recombination,brca1 deficiency,genomic instability
Cultural Heritage of Dictatorship in Albania (CHODIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-17
End date: 2018-10-16
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

In many Former ‘Eastern Bloc’ countries, underlying historical contingencies and unresolved conflict have led to the neglect of a rich cultural resource: remains of the recent past dating to the communist dictatorship period. The aim of the CHODIA project is to provide an in-depth assessment of the significance of the cultural heritage of the dictatorship period in Albania, a country that experienced one of the most oppressive regimes in the Former Eastern Bloc. CHODIA will comprise (1) a survey and analysis of the composition of the cultural heritage of the dictatorship period in all its components (monuments, memorials, public buildings and physical remains of various kinds), and (2) an investigation that, through various quantitative and qualitative methodologies, will allow the assessment of public perceptions of the heritage from this contested period of history (including its intangible aspects). Training received during this EF will include both detailed training by research, aided by staff highly specialised in the themes on which the project will focus, and the attending of both general and highly specific relevant courses on heritage, social anthropology (especially of the socialist and post-socialist period) and related qualitative and quantitative research methods. Such a combination of specialist knowledge and skills is not available in many places – Cambridge is one of few places able to offer the training required. This project will ultimately lead to a deeper understanding of how the past becomes heritage as well as of the inheritance of the experience of dictatorship today - leading to the re-appropriation and valorisation of Albania’s recent cultural heritage for the benefit of the public within and beyond Europe.

Keywords: albania,dictatorship,difficult heritage,tangible heritage,intangible heritage
Robust self-testing with applications to device-independent cryptography (ROSETTA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

The quantum revolution is happening now. Every day experimentalists around the world produce more complex, reliable and powerful quantum devices which take us one step closer to quantum computation, communication and cryptography. Testing is a crucial part of the development process necessary to ensure suitability of the device for the application in mind. Methods used for small devices quickly become impractical, as the devices become more complex and we need to develop efficient and robust testing procedures in order to make further progress. Fortunately, quantum physics is well-suited for this task, as it allows to precisely characterise devices under surprisingly weak assumptions. This feature, known as self-testing, is intrinsically related to the fundamental concept of Bell inequalities. The goal of this proposal is to develop efficient and robust testing procedures for complex quantum devices based on Bell's theorem. In the short-term these will allow experimentalists to efficiently characterise their devices, while in the long-term they will enable a customer to certify that a newly bought quantum device adheres to the specification, which opens the door to device-independent information processing. The timeliness of this proposal is demonstrated by the fact that the first loophole-free Bell experiments were reported within the last year. On top of practical applications, self-testing is important from the foundational point of view. By exploring the intimate connection between the quantum (microscopic) world of Hilbert spaces and the classical (macroscopic) world of resulting probability distributions, it provides the unique link between what we see and what is happening at the quantum level. This fellowship will allow Jędrzej Kaniewski to work under the supervision of Matthias Christandl (a world-class expert on quantum correlations) at the University of Copenhagen (a leading institution in both theoretical and experimental aspects of quantum mechanics).

Keywords: quantum cryptography,self testing,device independence,bell inequalities,non locality
Quantum Information Transduction with Acoustic Resonators (QUITAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 2305265.0
EU funding (EUR): 2305265.0
Participants: 1
Project status: SIGNED

Modern telecommunications networks make use of light in optical fibers to connect devices where information is processed in electronic circuits. Such an architecture can also be used to communicate and process quantum information. Local quantum processors based on superconducting (SC) microwave circuits are now capable of performing sophisticated tasks ranging from quantum simulation to quantum error correction. At the same time, low-loss quantum channels based on infrared (IR) light can transfer quantum information over long distances. However, the crucial link between these two systems that would allow for the realization of a quantum network is still missing. Since quantum states are much more fragile than classical signals, quantum transduction between the electrical and optical domains must be highly efficient without introducing new sources of decoherence that interfere with the operation of the local processors or long-distance channels. The goal of this project is to create a quantum transducer between SC circuits and IR light using a third quantum system: sound waves in an acoustic resonator. My recent work showed that these mechanical resonators possess properties that make them highly promising for implementing a quantum transducer. They couple efficiently to both SC circuits and IR light, and can be used to store and manipulate quantum states of sound. The project will combine electromechanical and optomechanical transduction, which so far has only been implemented separately, in a single system. By developing techniques for integrating optics, acoustics, and microwave circuits at cryogenic temperatures, I will demonstrate the conversion of complex quantum states between the microwave and IR domains and use this capability to entangle remote SC quantum nodes. Reaching this goal will be the crucial first step toward using SC circuits to implement a quantum network for long-distance communications or to build a large-scale, modular quantum computer.

Keywords: optomechanics,quantum transduction,superconducting circuits,brillouin scattering,acoustic resonators