Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NIMA: Non-invasive Interface for Movement Augmentation (NIMA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Germany,Serbia,France,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 3076488.75
EU funding (EUR): 3076488.75
Participants: 7
Project status: SIGNED

An artificial third arm that assists my actions with little cognitive effort and that can seamlessly be controlled concurrently and independently to my natural arms is a popular phantasm in science fiction. If to come true, however, this vision would revolutionise human life by enabling people to accomplish tasks that are sheer impossible with their natural limbs alone. Surgeons could become able to control additional surgical devices, a computer mouse commanded simultaneously to my fingers would enable me to operate a maps application on my phone while dragging my luggage, etc. The NIMA project follows a concrete and novel concept to make this vision a reality, by exploiting the redundancy of the motor system on different levels for controlling additional degrees-of-freedom of supernumerary limbs, devices or computers independently from movements of the natural limbs. We have formed a team of leading experts in neuroscience, neurotechnology, human-machine interfaces, robotics, and ethics, to accomplish the following objectives: 1) Pushing the borders of technology by creating non-invasive interfaces with multimodal sensory feedback that will allow effortless control of multiple limbs or objects, as well as a wearable supernumerary robotic limb. 2) Understanding the cognitive and neural mechanisms underlying movement augmentation, how it can be functionally embodied and how this can be facilitated by multimodal feedback, by combining neuromodulation, computational modelling and behavioural experiments. 3) Applying movement augmentation to extend human capacities and preparing the ground for exploitation, using three relevant testbeds: i) manipulation with a wearable supernumerary robotic arm and the two hands, ii) assistance in surgical manipulation to extend surgeon capabilities and autonomy, iii) 3-hands computer interface. 4) Evaluating the ethical and safety aspects of movement augmentation.

Keywords: neurotechnology,brain computer interface,robotics,motor augmentation
Development of a novel blood-based diagnostic test for colorectal cancer (Colodetect)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-10-01
End date: 2019-03-31
Duration (months): 42.0
Total project cost (EUR): 2490072.5
EU funding (EUR): 2309447.0
Participants: 1
Project status: CLOSED

A recent epidemiology of colorectal cancer (CRC) report demonstrated a significant CRC burden in European countries, which is still associated with very high mortality rates. The overall objective of the project is the development and commercialization of a test for the early detection of CRC based on the detection and measurement of cancer-specific autoantibodies present in blood of patients. The outlined test will detect simultaneously the presence in serum/plasma samples from CRC patients of specific autoantibodies (biomarkers) against a reduced number of tumor antigens (8-10). To reach this objective, several technological challenges have to be overcome, like to improve the sensitivity and detection limit in the early stages of CRC avoiding the obvious limitations provided by the invasive detection techniques extensively used, as the colonoscopy, and offering additional advantages compared to traditional CRC diagnostic methods, such the simplicity in applications, detection, accuracy and a reduced cost. The assay for the detection of CRC will be established and validated with clinical samples and tested for their marketability, to finally overtake the regulatory process to obtain the CE marking. The results obtained in this project will have extensive impact and benefits for European population at risk, since early detection programs are essential to decrease mortality around 30-35% and drastically reduce the treatment costs of people affected by the pathology, assuring the sustainability of the European healthcare systems and others in the world. The main objective of this project is to obtain a colorectal cancer diagnostic kit clinically validated and regulatory approved as an in vitro diagnostic product (IVD), and as well, to penetrate in the CRC diagnostic market allowing ProAlt to reach a competitive position by improving its competitiveness.

Keywords: colorectal cancer,elisa,biomarker,biochip,diagnostic,early diagnostic,healthcare,oncology market
Design Innovation Support Scheme for Tourism Industry (TOURISM ID)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Norway,Greece,United Kingdom
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2016-02-01
End date: 2017-07-31
Duration (months): 18.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The proposal aims to promote the interest and investment of small-and-medium-sized enterprises of Tourism Sector (SMEs) in relation to utilizing design and transforming design activity into tradable deliverables that manifest exploitation. To achieve this, three organizations that facing this issue with different expertise are joining forces to create the most suitable and sustainable supporting instrument. TOURISM ID project adopts a co-creation focused on breaking down the above barriers by evolving all the relevant stakeholders to the process for the creation of the dedicated Support Instrument for Innovation In tourism industry and gathering insights from the smes in order to reframe the barriers.

Keywords: innovation,design,service design,tourism industry
Autonomous Underwater Explorer for Flooded Mines (UNEXMIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Ukraine,Ireland,Spain,Italy,Spain,Belgium,Switzerland,Serbia,Finland,Greece,Hungary,Poland,Slovenia,Finland,Slovenia,Hungary,Czechia,Netherlands,United Kingdom,United Kingdom,Portugal,Portugal,United Kingdom
Call: New sustainable exploration technologies and geomodels (H2020-SC5-2015-one-stage, 2015)
Start date: 2016-02-01
End date: 2019-10-31
Duration (months): 45.0
Total project cost (EUR): 4862865.0
EU funding (EUR): 4862865.0
Participants: 32
Project status: CLOSED

This project will develop a novel robotic system for the autonomous exploration and mapping of Europe’s flooded mines. The Robotic Explorer (UX-1) will use non-invasive methods for autonomous 3D mine mapping for gathering valuable geological and mineralogical information. This will open new exploration scenarios so that strategic decisions on the re-opening of Europe’s abandoned mines could be supported by actualised data that can not be obtained by any other ways. The Multi-robot Platform will represent a new technology line that is made possible by recent developments in autonomy research that allows the development of a completely new class of mine explorer service robots, capable of operating without remote control. Such robots do not exist nowadays; UX-1 will be the first of its kind. Research challenges are related to miniaturisation and adaptation of deep sea robotic technology to this new application environment and to the interpretation of geoscientific data. Work will start with component validation and simulations to understand the behavior of technology components and instruments to the application environment. This will then be followed by the construction of the first Prototype. Post processing and data analysis tools will be developed in parallel, and pre-operational trials are launched in real life conditions. In the final stage of the project extensive pilots will take place during which UX-1 will be iteratively improved after each trial session, which will be increasingly demanding. The final, most ambitious demonstration will take place in the UK with the resurveying of the entire Ecton mine (UK) that nobody has seen for over 150 years. This final pilot will demonstrate the Platform’s scalability from small missions to the largest ones by increasing the number of deployed autonomous drones, and supporting multi-robot cooperation in confined 3D spaces with realtime sensor and data fusion for reliable navigation and communications.

Keywords: autonomy,robotics,surveying,field robotics,mineral exploration,underwater robotics
Internet of Thing for Smart Water Innovative Networks (IoT4Win)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Romania,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-03-01
End date: 2022-05-31
Duration (months): 51.0
Total project cost (EUR): 767065.83
EU funding (EUR): 767065.8300000001
Participants: 3
Project status: CLOSED

The IoT4Win will establish a European Industrial Doctorates (EID) training program and extend the traditional academic research training setting, equipping researchers with right combination of research-related and transferable competences, joint research training programme combines an interdisciplinary expertise of European research group, industry partners and user organisations, bring together all required knowledge, skills, and stakeholders to offer a comprehensive set of transferable skills and a training programme on ICT, data science and water engineering, including industry practice and longer-term benefit in further industrial partner collaborations and further knowledge transfer. IoT4Win will respond to well defined and interdisciplinary scientific questions and challenges on IoTs for Smart Water Network (SWN) technological area cooperating to recruit 3 ESRs to undertake research in the context of a joint research training on concepts and methodologies of IoT enabled SWN towards the PhD. IoT4Win designs 3 individual and personalised research projects covering the core SWN research areas, i.e. smart sensing and trusted communication within energy limited heterogeneous devices in IoT enabled urban water environment; dynamic sensor web and interoperable open platform with Integrated Knowledge Management for smart water networks; data security and intelligence in IoT enabled SWN. The interdisciplinary collaborations and cross industrial interactions between ICT and water sector, will expose researchers to the academic, non-academic sectors. By combining three projects, an interoperable, secure and intelligent underlying technology leading to an open platform for IoT enabled SWN applications will be developed. This platform will then be applied to and evaluated in the real water scenarios with our end user industrial partner, leading to a specialised technology platform for SWN and a best-practice smart water network demonstrator.

Keywords: internet of things,smart water networks,data intelligence and security,interoperability,semantic web,wireless sensor network,integrated data management
SET Plan – The 10th Year Anniversary Central European Energy Conference 2017 (SET Plan X-CEEC 2017)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Coordination and support actions
Countries involved: Slovakia
Call: Support to the 10th Conference on the European Strategic Technology Plan (SET Plan) 2017 (H2020-IBA-ENERGY-SETPLAN-2017, 2017)
Start date: 2017-08-01
End date: 2018-04-30
Duration (months): 9.0
Total project cost (EUR): 333331.25
EU funding (EUR): 249998.44
Participants: 2
Project status: CLOSED

The main objective of the project is the organization of the international conference 10th Year Anniversary SET Plan - Central European Energy Conference 2017. The 10th Year Anniversary SET Plan conference will be once again conjoined with the 11th annual Central European Energy Conference (CEEC 2017) and organised in Bratislava, Slovakia. The conference has an ambition to create a prestige international platform offering a floor for open discussion about the most important issues regarding current EU energy policy and research and innovation policy between relevant stakeholders. The conference will examine achievements in the implementation of the Energy Union with a special focus on the Low Mobility Package, State of Play of the negotiations of the 2016 Winter Packages, and the outcome of the 2017 Tour of Europe. In particular, the research and innovation achievements in Europe in the past 10 years that have supported the development of clean, sustainable, efficient and affordable energy technologies for low carbon energy systems in Europe. The conference will pay special attention to evaluation of the role of Central European member states, including their contribution to the implementation of the goals of the Energy Union and the Integrated SET-Plan. The conference will bring together researchers and policymakers from various member states, in particular, from the region of Central Europe, as well as a range of stakeholders from international organizations, research organisations, business, municipalities and civil society to encourage open debate around key energy issues. The program of the conference will consist of ten main panels, five parallel workshops held in a form of dinner sessions, poster session, and will also include side events.

Keywords: set plan,low carbon technologies,transformation,10th year anniversary,energy union,research,innovation,conference,slovakia,central europe
Innovative, preparation-free, bio-electrodes for next-generation wearable devices (Dryode)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We at IDUN have developed the Dryode™ - a portfolio of innovative bio-electrodes to enable wearables for future healthcare and Internet of Humans. The Dryode shows skin compliance and self-adhesive properties enabling unobtrusive, long-term, recordings with clinical-grade performance in biopotential monitoring such as Electromyography (EMG), Electrocardiography (ECG) and Electroencephalography (EEG). Dryode’s technology relies on surface geometry, rather than chemistry, to improve the bio-electrode’s adherence. Keeping contact with the skin, self-adherence minimizes motion artefacts. Our bio-electrodes are preparation free, comfortable and show an outstanding signal quality also in underwater conditions.

Keywords: bio electrodes,wearable devices
Industrial Residue Activation for sustainable cement production (ReActiv)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Germany,Estonia,Germany,Spain,Ireland,Italy,Austria,Belgium,Greece,Norway,Greece,Romania,Belgium,Belgium,France,United Kingdom
Call: Alternative mineral resources for high volume production (IA) (H2020-LCCI-2020-EASME-singlestage, 2020)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 10455975.36
EU funding (EUR): 8807929.38
Participants: 22
Project status: SIGNED

The ReActiv project will create a novel sustainable symbiotic value chain, linking the by-product of the alumina production industry and the cement production industy. Bauxite residue (BR) is the main by-product of the alumina sector produced at rates of 7 million tons per year in EU, while recycling rates are less than 100 thousdand tons per year respectively. In ReActiv modification will be made to both the alumina production and the cement production side of the chain, in order to link them through the new ReActiv technologies. The latter will modify the properties of the industrial residue , transforming into an active material (with pozzolanicor hydraulic activity) suitable for new, low CO2 footprint, cement products. In this manner ReActiv proposes a win-win scenario for both industrial sectors (reducing wastes and CO2 emissions respectively). To achieve its objectives the ReActiv project brings together the global leader in cement production with the bigest alumina producers along with top research and technology centers with significant expertise in the field. Furthermore the European alumina association and the international aluminium institute are participating in the project to safeguard the industrial dissemination and deployement of project results. The methodology developed under ReActiv can be replicated in by-products of other industrial sectors as well. To this end the project will seek to include in modelling and/or labscale enviroment other by-products in the developed flowsheets.

Keywords: low co2 cement,bauxite residue valorization,alumina,clinker substitution
Muscle Specific C. elegans Genome in health and disease: finding novel factors in 3D organization (MuSCel Genome)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

The loss of structural integrity in the interphase nucleus leads to tissue-specific pathologies in a set of human diseases collectively called laminopathies. These are late-onset, tissue-specific degenerative diseases, such as Emery Dreifuss Muscular Dystrophy (EDMD). While rare, these conditions provide insight into more common degenerative disorders linked to aging. A Caennorhabditis elegans mutant that recreates the EDMD phenotypes arises from introduction of a specific gain-of-function mutation into lamin (LMN-1 Y59C), which in turn affects the subnuclear distribution of muscle-specific promoters. This proposal plans to identify novel factors that establish and/or maintain the 3D organization of the genome in differentiated nuclei and to determine how this contributes to the differentiated muscle cell fate. I propose that compromised or altered sequestration of chromatin at the nuclear envelope alters cell-type specific promoter induction and in turn compromises the integrity of the tissue in question. The specific aims of the project are 1) To identify factors that establish and/or maintain 3D genome organization in muscle nuclei. 2) To determine if the integrity of the perinuclear chromatin binding machinery helps maintain differentiated cell states. 3) To test inhibitors of epigenetic regulators for compounds that overcome the EDMD-like LMN-1 Y59C mutation. I will take two complementary approaches to determine how muscle specific chromatin organization maintains tissue integrity. I will use in vivo biochemical tagging in the LMN-1 Y59C mutant to identify perinuclear components that mediate sequestration of muscle-specific gene promoters. In parallel, a drug screen will find compounds that reverse the nuclear disorganization linked to the EDMD-like phenotype. The pathways identified will explain how lamin-induced mis-organization of the genome influences muscle integrity, a topic relevant for muscular dystrophies, sarcopenia, and other degenerative disease.

Keywords: genome organization,heterochromatin,lamina,nuclear envelope,epigenetics,laminopathies,emery dreifuss muscular dystrophy,edmd,muscle,gene regulation
Exploring the cellular heterogeneity underlying 'tumor-educated' platelets (PlateletLiquidBiopsy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Cancer is one of the major causes of death worldwide. Early detection leads to treatment initiation in earlier cancer stages and therefore increases the chance of survival. However, appropriate diagnosis can be challenging because tissue acquisition of tumor samples for molecular testing often requires invasive procedure. To overcome these challenges researchers have focused on the real-time monitoring of molecules and cells in easily obtainable peripheral blood to gain diagnostic information, termed 'liquid biopsies'. A recent study by Best et al profiled purified platelet gene expression from cancer patients and healthy controls and was able to predict disease status and location of the primary tumor with 96% and 71% accuracy, respectively using a machine learning based algorithm. The pan-cancer nature of their finding is a major advancement compared to other liquid biopsy approaches and highlights the utility of platelets as an all-in-one platform for blood-based cancer diagnostics. We plan to advance the idea of platelet liquid biopsies by studying platelet single-cell RNA sequencing data from cancer patients and healthy controls. The overall goal of the proposed project is to investigate single platelet gene expression to gain insight into the molecular mechanisms underlying tumor driven changes in the platelet RNA profile.

Keywords: single cell,rna sequencing,platelet,liquid biopsy