Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Demographical effects of toxic contamination on Arctic seabirds (DeToxSea)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Mercury (Hg) concentrations in the oceans have tripled in the last centuries, even in remote areas such as the Arctic. Hg is bioaccumulated in food webs and can produce toxic effects affecting breeding and survival probabilities in wildlife. Selenium (Se) has been proved to have a protective effect against Hg toxicity, but no long-term studies have been carried out to evaluate reproductive output and population dynamics in relation to Se or the interaction Se-Hg. Using as a population model the most abundant breeding bird in the Arctic, the little auk (Alle alle), I aim to 1) evaluate the temporal trends of Se/Hg and on which intrinsic/extrinsic factors they depend on; 2) investigate if Se/Hg concentrations affect the reproductive output of little auks (i.e., at the individual level); and 3) evaluate the effects of Se/Hg at the population levels in the context of climate change (i.e., considering environmental conditions). To do so, I will use data of 15 years of monitoring on little auks from west Greenland (Kape Høegh). I will analyse pollutants on blood samples at the host laboratory, and I will perform different statistical approaches to investigate our objectives. In particular, we will look for functional relationships to evaluate pollutants temporal/environmental trends and their toxic effects on the reproductive output of little auks; and demographic models (multistate mark-recapture models and matrix population models) to evaluate the projected population growth rate and its sensitivity to Hg/Se and environmental conditions. This research program will gather knowledge from a large interdisciplinary team, with expertise in ecotoxicology and demography. We anticipate major public interest for the results of DeToxSea: the unique long-term study about demographic effects of Se/Hg toxic contamination in Arctic wildlife, that will give light to one of the Challenges of Horizon 2020 about Climate Action, Environment, Resource Efficiency and Raw Materials.

Keywords: ecotoxicology,contaminants,selenium,mercury,population dynamics,demography,capture mark recapture,matrix population models,global change,environmental conditions,arctic,seabirds,little auk
Nanoparticle-Based Imaging and Therapy of Chronic Pain in the Dorsal Root Ganglia (DRG) (PIANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Italy,Italy,Germany,Norway,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 3565136.22
EU funding (EUR): 3565136.2199999997
Participants: 11
Project status: SIGNED

Chronic pain is a debilitating disease, which affects approximately 1.5 billion people worldwide, and of those, approximately 4% suffer from neuropathic pain. Neuropathic pain is often described as a shooting or burning pain that can come and then disappear but equally it may become chronic, where the pain may become unrelenting and severe. It often is the result of nerve damage or a malfunctioning nervous system. Additionally there is the impact upon society where the costs related to disability allowance, treatment, lost wages and productivity impacts the economy. Current treatments for chronic pain are not fully reliable and there is a severe lack of tools to diagnose or visualise the pain process within the dorsal root ganglia (DRG). Humans have 62 DRGs which are the first relay stations in the pain pathway. Local targeted treatment at the level of those DRGs involved in the pain process is the solution to circumvent side effects and optimise treatment. We aim to identify involved DRGs by visualising cells or molecules in the DRG which are directly or indirectly associated with the generation of pain. We will use a novel method of nanoparticles targeted towards pain-associated cells or molecules in the DRG. A vast amount of neuropathic pain studies have shown an eminent infiltration of macrophages into affected DRGs. These nanoparticles will be specifically designed to target initially the macrophages in the DRG, encapsulating both therapeutic payloads and imaging contrast reagents to monitor pain-associated activities. The goal of PIANO is therefore to facilitate a state-of-art approach to visualisation of neuropathic pain / inflammation at DRG sites as well as to simultaneously release analgesic molecules from the nanoparticles.

Keywords: chronic pain,animal models,nanotechnology,molecular imaging,therapeutic intervention
European financial systems in post-crisis recovery (FINSYS RECOVERY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-15
End date: 2024-11-13
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

FINSYS RECOVERY i) provides a detailed view of how European financial systems (FS) evolved in the period 2005-2020; and ii) quantitatively investigates how shocks in the shape of crisis events (e.g. the global financial crisis, the EURO crisis and the COVID-19 pandemic) and related policy responses influenced FS trajectories across European countries in this period. The project seeks to generate new ways of understanding FS and their transformations by drawing on an interdisciplinary framework based on financial economics, political economy and corporate governance. By regressing panel data on macroeconomic outcomes and policy responses of different crises on an innovative country-based FS metric, it applies methods that are uncommon in research on FS. The FS metric enables the construction of a spectrum of FS across countries that can be tracked over time. This, in turn, allows for looking beyond the extant literature’s dichotomous conceptualization of FS as either bank- or market-based. In addition, it sheds light on issues that are often neglected in FS research, such as the role of cross-border listings or borrowing and the role of non-bank financial intermediaries. By using a large European panel dataset, the project seeks to generate new insights on the direction, speed and lag by which shocks influence FS. FINSYS RECOV thereby complements earlier research that typically focuses on how outcomes of shocks vary between different FS, or case-based research on how select small numbers of FS have responded to particular shocks. Generating insights on how FS respond to shocks, and if EU FS are converging or diverging, could hardly be timelier. There are ongoing political initiatives to promote deeper integration of EU FS, while at the same time counterfactors such as Brexit and nationalism appear to pull the EU apart. And this occurs against the backdrop of another major economic crisis, as the grip COVID-19 has tightened over our economies.

Keywords: comparative capitalism,varieties of capitalism,crises,economic policy,institutional change,corporate funding and governance
Making Sense (Making Sense)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,Netherlands,Netherlands,United Kingdom,Kosovo
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2015, 2015)
Start date: 2015-11-01
End date: 2017-12-31
Duration (months): 26.0
Total project cost (EUR): 1547774.5
EU funding (EUR): 1547774.5
Participants: 6
Project status: CLOSED

The raise of Fab Labs and maker spaces are creating new opportunities for citizen-driven innovation in a myriad domains ranging from open hardware to digital fabrication, community informatics, and participatory sensing. In the past five years, the broad availability of open hardware tools, the creation of online data sharing platforms, and access to maker spaces have fostered the design of low cost and open source sensors that independent communities of citizens can appropriate to engage in environmental action. By collectively measuring and making sense of changes in environmental phenomena citizens can become aware of how their lifestyle affects the ecosystem and be inspired to adopt more sustainable behaviours at the individual and community levels. Making Sense will show how open source software, open source hardware, digital maker practices and open design can be effectively used by local communities to appropriate their own technological sensing tools, make sense of their environments and address pressing environmental problems in air, water, soil and sound pollution. To achieve this, the project will develop a Making Sense Toolkit based on the Smart Citizen platform for bottom up citizen science, developed at Fab Lab Barcelona. The toolkit will be tested in pilots in Amsterdam, Barcelona and Prishtina, aimed at deepening our understanding on the processes enabling collective awareness. Based on the pilots, we will develop a conceptual and methodological framework for participatory environmental maker practices. It will show how to provide citizens and communities with appropriate tools to enhance their everyday environmental awareness, to enable active intervention in their surroundings, and to change their individual and collective practices. And finally we will develop will develop a scientifically informed framework for citizen co-inquiry and action towards hands-on transformation of their surroundings.

Keywords: crowdsensing,bottom up sensor networks,sense making,smart citizens
3D Stretchable Inductive Tactile Sensors for Soft Artificial Touch (3D-SITS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-06
End date: 2020-09-05
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Tactile sensors are essential components that enable robotic systems to interact safely and effectively with humans and the environment, they also offer significant potential for use in modern healthcare systems. Compared to visual and auditory senses, the tactile sensory system provided by human skin are complex, combining large number of high performance, multi-modal sensory elements in soft 3D structures to extract information during interaction with objects. To be effectively applied in real-world environments, tactile sensors must have both high compliance and high performance, and also need to be durable and robust to the repeated physical interaction. Researchers seeking innovations in tactile sensing have explored and exploited new materials, novel composites/structures, fabrication techniques and transducer mechanisms. Although remarkable progress has been made in developing 2D flexible sensing skins, a third dimension in soft sensing technology should be investigated to emulate multimodal, highly sensitive receptors, and ultimately the human sense of touch. This action involves an experienced researcher, Dr Hongbo Wang, under the supervision of Dr Lucia Beccai for 24 months to work on the project “3D Stretchable Inductive Tactile Sensors for Soft Artificial Touch” (3D-SITS), at the Center for Micro-BioRobotics of the Italian Institute of Technology (IIT) in Italy. In this project, I propose to use elastomers with embedded helical coils and zig-zag planar coils to form multi-modal, stretchable sensing nodes. By investigating this overlooked transducer mechanism, together with novel design and fabrication techniques, that allow us to build truly soft, durable, high-performance, distributed, 3D tactile sensing systems at component level (artificial receptors) and then system level (soft robotics and wearable skin), providing a leap forward in the area of artificial touch for the next generation of robots, wearable systems and human–machine interfaces.

Keywords: soft tactile sensing,inductive coils,bio inspired design,soft robotics
Cyber Security for Cross Domain Reliable Dependable Automated Systems (SECREDAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Italy,Austria,Austria,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Austria,Austria,Germany,Germany,Germany,Germany,Spain,Italy,Italy,Tunisia,Finland,Hungary,Poland,Romania,Finland,Finland,Sweden,Belgium,Sweden,Greece,France,France,France,France,France,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,Portugal,Portugal,Portugal
Call: RIA (H2020-ECSEL-2017-2-RIA-two-stage, 2017)
Start date: 2018-05-01
End date: 2021-10-31
Duration (months): 42.0
Total project cost (EUR): 51074120.03
EU funding (EUR): 14816246.3
Participants: 77
Project status: CLOSED

Title : Cyber Security for Cross Domain Reliable Dependable Automated Systems. Goal : SECREDAS aims to develop and validate multi-domain architecting methodologies, reference architectures & components for autonomous systems, combining high security and privacy protection while preserving functional-safety and operational performance.
Cutting edge technology: understanding Palaeolithic stone tool design and use from a modern mechanical engineering perspective (EDGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 2
Project status: CLOSED

For over 3 million years, stone tools were central to the survival of hominins (fossil and modern humans). Their ability to cut, pierce and scrape materials opened new ecological niches, facilitated exploitation of novel resources, and allowed hominins to survive in hostile environments. Accordingly, there were strong pressures for stone tools to be effective, reliable, durable, and efficient. Modern cutting tools are produced according to similar principles and there is >80 years of research dedicated to designing mechanically-optimised tools and understanding the principles of cutting. However, Palaeolithic stone technologies have yet to be investigated with similar mechanical or theoretical rigour. EDGE will integrate advanced engineering analytical techniques, principles and design theory with large-scale archaeological experiments to investigate how the morphology, microgeometry, and raw material choice of stone cutting tools influences their performance and fracture mechanics. In archaeological firsts, EDGE includes controlled cutting tests, empirical analyses of stone tool sharpness, and finite element analysis (FEA) of cutting processes. Palaeolithic artefacts will be examined to assess whether our hominin ancestors actually designed mechanically-optimised tools, or, alternatively, whether other factors (e.g. cultural variation) underlie the tool type, form and raw material variability observed across the Palaeolithic archaeological record. The ground breaking nature of EDGE is its integration of advanced engineering techniques and principles with archaeological experiments and artefact analyses to address fundamental questions concerning early human behaviour. Results will provide a fundamental shift in how functional archaeological experiments are performed, establish fracture mechanics theory and FEA within archaeological research, and present a robust mechanically defined framework necessary for understanding artefact variation across the Palaeolithic.

Keywords: palaeolithic archaeology,stone tool,function,cutting,fracture mechanics,design,prehistoric behaviour
CAncer Stem Cell Imunoreceptors as potential Targets for skin Squamous cell carcinoma (CApaCITy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Cancer stem cells (CSC) initiate, sustain the prevalence, and resistance to therapy of skin squamous cell carcinomas (SCC). It is well acknowledged that CSC self-renewal and clonal growth is governed by genetic mutations, but also by complex interactions between CSC and the microenvironment. Genetic therapy is difficult to achieve in clinical settings, therefore, targeting cells of the supportive tumor microenvironment is a promising advance to eradicate SCC. Using mouse models of SCC, our previous basic research results uncovered the existence of a direct crosstalk between skin CSC and tumor-associated macrophages (TAM) via Wnt signaling. Interestingly, we observed that Wnt regulated the expression of three CSC receptors, CD99, MFGE8 and Nectin-2, and governed the CSC-TAM crosstalk. Here, I propose to expand this basic research into a translational perspective, to explore the potential of CD99, MFGE8 and Nectin-2 as therapeutic targets for human SCC. There is a major interest in this arena, since the major caveat of targeting Wnt signaling in cancer is the lack of specificity to target CSC, without affecting somatic cells. Moreover, most clinical trials have not been fully efficient to dampen the Wnt response in tumors. Using a comprehensive and integrated approach based on human SCC, cell biology, omics and medical chemistry, along with powerful patient derived xerographs (PDX), my results must likely unearth a role for these immunoreceptors in governing the CSC-TAM crosstalk, and their potential as drug targets for human SSC. This interdisciplinary project will be conducted at the University of Copenhagen (UCPH) in Dr. Perez-Moreno, Dr. Merete Haedersdal, and Dr. Strømgaard groups. Through the CApaCITy project, I will embark in a leading research area with several possibilities to grow into an independent international researcher.

Keywords: squamous cell carcinoma,cell cell interaction,cancer stem cells,macrophages,immunoreceptors
Innovative strategies, sensing and process Chains for increased Quality, re-configurability, and recyclability of Manufacturing Optolectronics (IQONIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Germany,Italy,Italy,Italy,Germany,Finland,Greece,Switzerland,Switzerland,Greece,Greece,Czechia,United Kingdom,United Kingdom
Call: Innovative manufacturing of opto-electrical parts (RIA) (H2020-NMBP-FOF-2018, 2018)
Start date: 2018-10-01
End date: 2022-09-30
Duration (months): 48.0
Total project cost (EUR): 7997968.75
EU funding (EUR): 7997968.75
Participants: 19
Project status: CLOSED

Advances in optoelectronics technologies is causing a revolution in consumer electronic goods, solar energy, communications, LED, industrial laser, and other fields. At present, the optoelectrical manufacturing is facing significant challenges in dealing with the evolution of the equipment, instrumentation and manufacturing processes they support. The industry is striving for higher customisation and individualisation, implying that systems configurations need to change more frequently and dynamically. IQONIC will offer a scalable zero defect manufacturing platform covering the overall process chain of optoelectrical parts. IQONIC covers the design of new optoelectrical components and their optimised process chain, their assembly process, as well as their disassembly and reintroduction into the value chain. IQONIC will therefore comprise new hardware and software components interfaced with the current facilities through internet of things and data-management platforms, while being orchestrated through eight (8) scalable strategies at component, work-station and shopfloor level. The IQONIC technologies will be demonstrated in 4 demo sites covering a wide range of products and processes. The impact of IQONIC to the European optoelectronics manufacturing industry, but also the society itself, can be summarised in the following (with a horizon of 4 years after project ends): (i) increase of the in-service efficiency by 22%, (ii) increased flexibility with 16% faster reconfiguration times, (iii) 10% reduction in production costs through recycled components and materials, (iv) improved designs for assembly and disassembly and, (v) about 400 new jobs created and (vi) over 39 MEUR ROI for the consortium. To do that we have brought together a total of seventeen (17) EU-based partners, representing both industry and academia, having ample experience in cutting-edge technologies and active presence in the EU photonics and manufacturing.

Keywords: assembly,zero defect,life cycle,recycling,opto electronics