Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel Coding Factors in Heart Disease (CodingHeart)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2319514.0
EU funding (EUR): 2319514.0
Participants: 1
Project status: SIGNED

Heart failure has become a worldwide epidemic with more than 23 million people affected resulting in devastating consequences for patients and an enormous burden on health care systems. One in five heart failure patients dies within a year of diagnosis and survival estimates after diagnosis are 50% and 10% at 5 and 10 years, respectively. Despite intensive investigation, the molecular mechanisms leading to heart failure remain poorly understood. We will narrow this critical gap in knowledge by proposing a previously unattainable, comprehensive approach to define the genomic architecture and functional consequences of newly identified micropeptides from multiple classes of RNAs that previously were classified to be non-coding in cardiac biology and heart failure. Our approach is unique and novel in several ways. Thematically, our studies focus on novel classes of orphan peptides and their role in heart failure that have not been discovered previously. Our approach relies on innovative interdisciplinary efforts of scientists working in molecular genetics, genomics, computational biology, and cardiovascular research to identify and characterize pathophysiological pathways that converge on these novel peptides. We will identify these short peptides by using genome-wide measures of active translation and will harness unique clinical resources to ensure human relevance. Analysis of animal and cell models coupled with state-of-the-art biochemical and genetic tools will elucidate the function of newly identified micropeptides within the molecular and cellular pathways of cardiac biology and failure. Through these efforts we will discern fundamental causes of maladaptive responses in the heart and strategies to monitor and limit these.

Keywords: cardiovascular genetics and genomics,cardiovascular sciences,heart,heart failure,gene expression,long non coding rna,circular rna,functional genomic
Highly Competent and Safe Titanium(IV) Therapeutic Frameworks that are Cancer Targeted based on Complex 1, 2, and 3D Chemical Architectures (TiDrugArchitectures)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2022-05-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

This proposal aims to develop custom designed anticancer therapeutic frameworks that are effective, stable, safe, and tumor targeted, based on the biocompatible TiIV metal. The Tshuva group has established that water stable phenolato TiIV complexes are especially effective as anticancer agents both in vitro and in vivo, with markedly reduced side effects. Optimal derivatives will be developed to combine activity, stability, and biological accessibility, by maintaining small steric bulk while incorporating strong binding donors and hydrophilicity. The mechanism of action will be investigated by chemical and biological methods, including analyzing bio-distribution, cellular pathways and targets, and interaction with bio-molecules. Specifically, the active metal centers will be linked to bioactive moieties through redox-sensitive S–S bonds to enable tumor targeting. Cell penetrating peptides will facilitate cellular penetration for redox-dependent release of the active species selectively in cancer cells; steroid moieties will direct selectivity to hormone-dependent cancer cell types. Since the combination of TiIV- with Pt-based drugs has shown synergistic effects, multi-active entities will include two or more metal centers, possibly also linked to a transport unit. In addition to linear conjugates, polymeric and dendritic assemblies, exploiting the enhanced permeability of cancer cells, will be constructed with theoretically unlimited options for targeted delivery of multiple active sites. Most importantly, flexible well-defined redox-sensitive cages, as well as rigid pH sensitive complex cages, constructed with customized 3D geometries, will enable specific targeting of any active compound or conjugate and selective dissociation only where desired. This study should yield superior anticancer drugs, while unraveling the mystery of their complex biochemistry, and will contribute to the development of novel chemical and medicinal research directions and applications.
Superconducting Spintronics for Highly Energery Efficient Cryogenic Memory Applications (SUPERSPIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

The dissipation of heat in traditional silicon (CMOS) based electronics is a major source of inefficiency and environmental impact. Superconductors are, by nature, dissipationless. Computing via logic circuits based on Josephson junctions is also faster, but the largest remaining problem is the lagging development of low-temperature memory. To achieve the promised efficiency increases of these computers requires a new type of low-temperature memory architecture. Traditionally considered competing phenomena, when artificially juxtaposed a wealth of physics at the interface between superconductors and ferromagnets emerges. Spin-polarised Cooper pairs are capable of surviving inside a ferromagnet over much longer distances than the regular (spin-singlet, anti-parallel) pairs. This new type of Cooper pair is the building block for super-spintronics; leading to a dissipationless spin-current combined with spintronic devices. Europe risks being left behind by large US research efforts such as the IARPA C3 programme. SUPERSPIN will take advantage of spin-polarised Cooper pairs for the promising application of cryogenic memory, where information can be stored by either the state of the system (superconducting or normal), or in the phase difference between superconductors across a Josephson junction. The outgoing host Prof. Birge is the world leading expert in ferromagnetic Josephson junction devices for cryogenic memory application. The fellow will be fully integrated in his IARPA C3 funded laboratories and through the SUPERSPIN programme, of exploring candidate materials systems and developing prototypical devices, will acquire all the skills and knowledge necessary to develop these exciting advances to application the E.U. during the return phase of the project. Through SUPERSPIN, the fellow will broaden his scientific background, develop complementary knowledge in new areas, bring new knowledge from the TC host to the E.U. and increase his chances of success in academia
The Ties that Bind: Experimental Analyses of Political Solidarities in Modern European Democracies (POLITSOLID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Austria,Germany,Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1998525.0
EU funding (EUR): 1998525.0
Participants: 3
Project status: SIGNED

POLITSOLID investigates the micro-foundations of political solidarities in fast-changing European polities. It analyses why some ordinary citizens show a high overall willingness to shoulder costs of public redistribution to other people in a polity, while others do not; and why ordinary citizens have multiple levels of willingness to shoulder costs depending on who receives the benefit. Relevance: Having high levels of political solidarities is important for modern democracies to deal with exogenous shocks and long-term structural changes in their societies, which create pressures on the political system. Recent exogenous shocks in Europe that brought the necessity of political solidarities to light were the financial crisis (2007/8) with its extensive transnational bail-out policies across the European Union and the large refugee intake (2015/16). Relevant long-term structural changes are population ageing, rising income inequality and mass immigration. This project answers the overarching research question: What drives political solidarities in modern European democracies? Objectives • To create a novel theoretical and empirical framework that allows simultaneous modelling of multiple political solidarities and that includes the individual as well as the macro levels to enable better predictions about how people behave. • To test causal mechanisms with a range of mostly experimental methods to get a better understanding of causality where observational studies have so far dominated. • To isolate effective levers that political actors can pull to create political solidarities. Data: POLITSOLID collects and analyses new data from (1) lab experiments & online surveys, (2) a simulated artificial state ‘Novaland’ in which volunteers from Austria, Germany & Switzerland act as citizens in an online environment, with experimental treatments applied, (3) an international panel survey in six countries and (4) field experiments in collaboration with real political actors.

Keywords: public redistribution,welfare state,solidarity,experiments,attitudes,survey,europe,public policy
Quantifying and Deploying Responsible Negative Emissions in Climate Resilient Pathways (NEGEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Belgium,Switzerland,Finland,Sweden,Norway,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Negative emissions and land-use based mitigation assessment (H2020-LC-CLA-2019-2, 2019)
Start date: 2020-06-01
End date: 2024-05-31
Duration (months): 48.0
Total project cost (EUR): 5817835.0
EU funding (EUR): 5817835.0
Participants: 17
Project status: SIGNED

The quantitative potential, effectiveness and impacts of negative emission technologies and practices (NETPs), particularly taking into account relevant disciplines such as sustainability, socio-political and socio-economic sciences, are not so well understood. Based on a multi-discipline approach, with world-leading experts that can show proven track records in technological, economic and socio-political disciplines, NEGEM will go beyond the perspectives of climate physics and climate economics currently providing the basis for climate scenario modelling. The novel approach of NEGEM is the focus on a real-world perspective, where the theoretical potential of NETPs will be filtered through a range of key performance indicators relevant to biogeochemical cycles, ecosystems and planetary boundaries, resource economies, societal dimensions, social acceptability, technological opportunities and constraints, multi-level governance, and the sustainability transition. Through this, NEGEM will address to what extent NETPs are required to achieve climate neutrality and how their associated technical, economic and socio-political impacts potentially limit their contribution. The result is a comprehensive analysis of the realistic, sustainably deployable potential of NETPs supporting EU’s endeavours to implement the Paris Agreement within the frames of relevant UN Sustainable Development Goals. The NEGEM analysis will feed into a comprehensive framework with guidance on how to create, select, analyse and disseminate pathways with NETPs. This framework will be used to identify a set of pathways to achieve climate neutrality, which helps lay the basis for the medium-to-long term vision needed to support EU’s endeavours to implement the PA within the context of relevant SDGs. NEGEM will dedicate specific efforts to reaching out to key stakeholders, in particular to policymakers at national and EU levels, but also to key international stakeholders, including developing countries.

Keywords: negative emissions,climate neutrality,governance structures,public acceptance
Morphogenesis during pre-implantation development: molecular and mechanical regulation (MECHABLASTO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1497691.0
EU funding (EUR): 1497691.0
Participants: 2
Project status: CLOSED

During the first days of mammalian development, blastomeres organize themselves into the blastocyst, which implants the embryo into the maternal uterus. Failure to build the blastocyst will result in a miscarriage and yet the mechanisms underlying the construction of the blastocyst are mostly unknown. The blastocyst is sculpted by forces generated by its constituent cells. Without a tool to study the mechanics of the mammalian embryo, it is challenging to identify the molecules and cellular processes controlling morphogenetic forces. Using biophysical methods, I have recently measured the forces shaping the mouse blastocyst and identified cellular processes generating and controlling them. This approach enables the identification of the molecules controlling morphogenesis and constitutes the first step towards a complete theoretical modelling of blastocyst morphogenesis. The aim of this project is to understand the molecular and mechanical aspects of blastocyst morphogenesis. By developing novel biophysical tools for the developing blastocyst, we will measure uncharacterized mechanical properties such as cytoplasmic and luminal pressure, adhesion strength and viscosity. The resulting mechanical map of the blastocyst will help understand the mechanisms of action of genes involved in its morphogenesis. To identify novel candidate genes involved in blastocyst morphogenesis, we will carry out a screen using live high-resolution confocal microscopy of mouse embryos injected with siRNA. Together, this will reveal the molecular, cellular and mechanical processes controlling blastocyst morphogenesis. I expect this to shed light on how blastomeres self-organize into the blastocyst and to reveal the physical laws underlying morphogenesis in general. Importantly, the knowledge and non-invasive biophysical techniques that we will develop will help developing Assisted Reproduction Technologies, which will be greatly beneficial to the fertility of the ageing European population.
The Combined Effects of Climatic Warming and Habitat Fragmentation on Biodiversity, Community Dynamics and Ecosystem Functioning (FRAGCLIM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1998802.0
EU funding (EUR): 1998802.0
Participants: 1
Project status: SIGNED

Climatic warming and habitat fragmentation are the largest threats to biodiversity and ecosystems globally. To forecast and mitigate their effects is the environmental challenge of our age. Despite substantial progress on the ecological consequences of climatic warming and habitat fragmentation individually, there is a fundamental gap in our understanding and prediction of their combined effects. The goal of FRAGCLIM is to determine the individual and combined effects of climatic warming and habitat fragmentation on biodiversity, community dynamics, and ecosystem functioning in complex multitrophic communities. To achieve this, it uses an integrative approach that combines the development of new theory on metacommunities and temperature-dependent food web dynamics in close dialogue with a unique long-term aquatic mesocosm experiment. It is articulated around five objectives. In the first three, FRAGCLIM will determine the effects of (i) warming, (ii) fragmentation, and (iii) warming and fragmentation combined, on numerous facets of biodiversity, community structure, food web dynamics, spatial and temporal stability, and key ecosystem functions. Then, it will (iv) investigate the extent of evolutionary thermal adaptation to warming and isolation due to fragmentation, and its consequences for biodiversity dynamics. Finally, (v) it will provide creative solutions to mitigate the combined effects of warming and fragmentation. FRAGCLIM proposes an ambitious integrative and innovative research programme that will provide a much-needed new perspective on the ecological and evolutionary consequences of warming and fragmentation. It will greatly contribute to bridging the gaps between theoretical and empirical ecology, and between ecological and evolutionary responses to global change. FRAGCLIM will foster links with environmental policy by providing new mitigation measures to climate change in fragmented systems that derive from our theoretical and empirical findings.

Keywords: climatic warming,habitat fragmentation,food webs,spatial ecology,ecosystem functioning,stability,diversity
Excellence, International, Intersectoral and Interdisciplinary doctoral training at Ecole Centrale Lyon in cotutelle with royal melbourne institute of technology AUStralia (E3I ECLAUSion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2019-09-01
End date: 2025-08-31
Duration (months): 72.0
Total project cost (EUR): 1569600.0
EU funding (EUR): 784800.0
Participants: 1
Project status: SIGNED

E3I ECLAUSion, a joint venture between Ecole Centrale de Lyon (ECL) and RMIT University, Melbourne Australia aims to build a highly nurturing and multi-faceted PhD training environment that would benefit the emergence (‘eclosion’) of the next generation - 10 doctoral fellows in 2 cohorts- of not only highly skilled researchers but also entrepreneurs with an international mind-set and interdisciplinary training. Specifically ECLAUSion, in line with the MSCA guidelines, the EU principles for Innovative doctoral training and the code of conduct, aims to i) Reinforce research excellence in ECL in partnership with RMIT and increase scientific output and international visibility; ii) Expand on existing doctoral programs by attracting highly promising international early career researchers to ECL and providing a nurturing environment with global reach (both in terms of scientific supervision, mentoring, working conditions, administrative support and social life). We envision two calls being organized, with 5 doctoral contracts per call being offered (total number of PhDs offered 10) so that every researcher can receive their PhD degree during the 5 years program; iii) Educate and train these ESRs; enhance their research and transferable skills with a 3i dimension by offering them Interdisciplinary research options, exposure to Industry (both at local, regional and international levels), and an inherently International network to maximise their opportunities and their emergence into successful professionals in their future careers iv) Leverage the existing rich biotech and ICT local/regional/global ecosystem and capitalise on it to develop new synergies between academia and the private sectors and more generally v) Strengthen EU-Australia research collaboration in key areas for investment and growth in particular in Health; Biotechnology, Environment; Energy; Information and communications technologies; Nanotechnologies, materials and production technology.

Keywords: international,intersectoral,interdisciplinary,nurturing and multi faceted phd training program,career development,industry engagement,eu australia research collaboration,ecl rmit joint venture