Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting Cancer Stem Cells (CSC) for the development of more effective treatments to cure cancer patients (ANTI-CSC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Spain
Call:  (ERC-2012-PoC, 2012)
Start date: 2012-12-01
End date: 2013-11-30
Duration (months): 12.0
Total project cost (EUR): 161613.03
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Global cancer market is growing at a CAGR of 6.9% with an estimated value of $81bn in 2016. Although the huge R&D investment observed in the past years in the development of new treatments, there is still lack on an effective treatment in many tumour types. In particular, the median survival for glioblastoma multiforme (GBM), a high-grade brain tumour affecting 23,000 patients a year in US and EU, is 14 months and its 5-yr survival less than 5%. It is therefore urgent to develop more effective treatments against this fatal disease. It has been recently demonstrated that Cancer Stem Cells (CSCs) are responsible from tumour initiation, maintenance, relapse and treatment resistance, and therefore therapies targeting CSC should eradicate the tumour. Our team has discovered a molecular pathway critical in the regulation of CSC. The project presented here entails the proof of concept and pre-clinical development of a humanized antibody blocking this pathway. Our murine version of the antibody blocks CSC development in vitro by 54% and tumour recurrence in a mice model by 50%. At the end of the ERC POC project we will have a patent protected and fully humanized antibody active in vivo and in vitro and ready to enter Phase 1 clinical trials in humans to continue its commercialization process. The forecasted annual peak revenue for this therapeutic antibody is $530M with additional sales coming from line extensions in other cancer indications. With the ERC POC project we are dramatically increasing the commercial value of the therapeutic antibody, transforming an R&D finding (CSC are critical for cancer development) into a potential new solution to patients (a therapeutic antibody targeting CSC). Hence, we are de-risking the product, advancing it through the commercialization path and creating a product and a commercial data package with a good expectative in the cancer market that is ready to be out-licensed or transferred to a spin-off previous VC investment.

Keywords: 205819
Sustainable Silks Programme (SABIP-SUSI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-01-01
End date: 2013-12-31
Duration (months): 12.0
Total project cost (EUR): 126768.0
EU funding (EUR): 113034.0
Participants: 1
Project status: CLOSED

Silks are fully sustainable, non-perishable and climate-smart agricultural products. They are uniquely suited for areas of low-wage/high-unemployment and fragile ecosystems sensitive about water and soil. At the same time, silks and silk-derived materials are used for simple as well as highly sophisticated applications and products with low to high potential for adding value with rather moderate investment. The Oxford Silk Group’s research on the ERC funded “Silk as Biomimetic Ideals for Polymers” led to a number of novel and important insights that combine proprietary know-how with patented concepts. A key invention allows a wide range of novel silks to be accessed - thus freeing the global industry from the heavy reliance on mulberry silks and adding novel wild silks to the market. This, together with other original insights and innovations, and combined with Silk ‘Life Cycle Analysis’ allows now the planning and execution of novel silk projects in an economically robust as well as environmentally sustainable way. Our unique selling points are: (1) our Oxford research group is one of very few market leaders globally in the field of R&D on silks and has (2) unique insights in wild silk IP, in addition to (3) a pipeline of novel, sustainable silk products combined with (4) proprietary LCA models developed from silk farms around the world and derived from a rapidly developing and extensive network of collaborators.

Keywords: 233409
FRET-based receptor screening assays (FRESCA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Germany
Call:  (ERC-2012-PoC, 2012)
Start date: 2014-01-01
End date: 2014-12-31
Duration (months): 12.0
Total project cost (EUR): 149345.25
EU funding (EUR): 149345.0
Participants: 1
Project status: CLOSED

This project intends to prepare the commercialization of a new, patent-protected, generic technology to identify and characterize potential drugs acting at G-protein-coupled receptors (GPCRs). GPCRs represent prime targets for therapeutic drugs, variously estimated at 25-50% of all therapeutic targets, including multi-billion € drugs for major diseases, such as beta-blockers or antihistamines. However, of the hundreds of GPCRs, only 82 are currently used as therapeutic targets, and many still lack the identification of their endogenous ligands, indicating the vast potential of these receptors for further drug development. The project is based on results of the ERC-AdG “TOPAS” (ID: 232944), where we have developed sensors for receptor activation and signaling based on fluorescence resonance energy transfer (FRET). In particular, we have developed new sensors that contain a GPCR and two fluorophores, capable of directly reporting receptor activation. The University of Würzburg has obtained broad patent rights for such sensors. Such FRET-based receptor screening assays (FRESCA) have the potential to discover new, innovative GPCR drugs. We intend to explore the usability and scalability of FRESCA for drug screening purposes in the pharmaceutical and biotech industry. We will validate FRESCA in comparison to current standards, and under high-throughput screening conditions. We expect that FRESCA can replace standard radioligand binding assays as the first line of drug screening. FRESCA further show the potential to define the properties and effects of drug candidates at GPCRs, by measuring directly the activation step (conformational change) of GPCRs rather than the many different downstream steps that are activated by GPCRs. This indicates the broad applicability of FRESCA as “all-in-one” assays for GPCRs and their commercial potential in biomedical and in drug research. We intend to establish in this project the basis for a FRESCA-based start-up biotech company.

Keywords: 232944
Engineered Sequence-Specific RNases: New Reagents for RNA biotechnology (ERNASES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Poland
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-01-01
End date: 2013-12-31
Duration (months): 12.0
Total project cost (EUR): 159200.0
EU funding (EUR): 149970.0
Participants: 1
Project status: CLOSED

The basic idea to be taken to the proof of concept is creation of novel molecular biology tools, ie. enzymes acting on DNA/RNA hybrids and dsRNA that are able to cut the RNA strand(s) in a site specific manner. We have already created prototypic proteins of those two classes of ‘RNA restriction enzymes’ and performed initial steps towards commercialization of the project. We are applying for funding to 1) ensure the best available patent protection, 2) finish the prototypes and validate the approach and 3) perform detailed market research.

Keywords: 261351
System Automation of PEMFCs with Prognostics and Health management for Improved Reliability and Economy (SAPPHIRE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Norway,Germany,France,Croatia,Germany,Denmark
Call:  (FCH-JU-2012-1, 2012)
Start date: 2013-05-01
End date: 2016-04-30
Duration (months): 36.0
Total project cost (EUR): 3269417.1
EU funding (EUR): 1745140.6
Participants: 6
Project status: CLOSED

The SAPPHIRE project will develop an integrated prognostics and health management system (PHM) including a health-adaptive controller to extend the lifetime and increase the reliability of heat and power-producing systems based on low-temperature proton-exchange membrane fuel cells (LT-PEMFC). The PHM system can actively track the current health and degradation state of the fuel-cell system, and through the health-adaptive control counteract the degradation of cells and balance of plant, and thereby boost the lifetime of the controlled system beyond the current lifetime expectancy. An important part of project is to develop novel prognostics approaches implemented in the PHM for estimation of the remaining useful life (RUL) of the PEMFC. An efficient sensor configuration for control will be chosen using controllability analysis methods, also including indirect sensing/estimation techniques to replace expensive measurement principles. Based on sensor inputs and input from the control system, the PHM algorithms identify the probable failure modes trajectories and estimate the remaining useful life. The consortium’s competence ranges from first principles estimation, to signal processing, regression and data-driven techniques, such as neural networks. This ensures an efficient choice of methods. The project covers a full cycle of research activities, from requirement specification and laboratory experiments, through study of degradation phenomena and selection of prognostic methods, to synthesis of the control system and its testing on the target PEMFC system. A technical-economical analysis will be performed in order to assess the impact of the developed tool in terms of lifetime improvement. The project is expected to produce hardware and software solutions and have a significant scientific output. The implemented solutions resulting from the project will be tested and validated by the research and industrial partners.

Keywords: fuel cells,stationary,chp,prognostics,health management,reliability,control
Operation of a Novel Sofc-battery Integrated hybrid for Telecommunication Energy systems (ONSITE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Italy,Switzerland,Poland,Germany,Germany
Call:  (FCH-JU-2012-1, 2012)
Start date: 2013-07-01
End date: 2017-09-30
Duration (months): 51.0
Total project cost (EUR): 5571479.44
EU funding (EUR): 3012038.0
Participants: 8
Project status: CLOSED

SOFCs are good energy sources to supply reliable power at steady state. Due to their slow internal electrochemical and thermodynamic characteristics, they cannot respond to electrical load transients as quickly as desired. During peak demand a battery can provide power in addition to the fuel cell, whereas the fuel cell can recharge the battery during low demand periods. The key advantage of this system architecture is that the fuel cell is operated without major load variations close to constant load resulting in longer lifetime and thus reducing total costs of operation. The realization of a hybrid system, capable of connecting production and storage devices on the one hand, and of managing and controlling the energy and its exchange with the power grid on the other hand, represents the synergy of some innovative technologies, but already commercially available. The overall objective of ONSITE is the construction and operation of a containerized system, based on SOFC/ZEBRA battery hybridisation, that generates more than 20 kW at high efficiency and economically competitive costs. High Temperature ZEBRA batteries (NaNiCl) are intrinsically maintenance free, show long life and are fully recyclable. The choice of this kind of technology aims at exchanging thermal energy between the two devices, in order to enhance the total efficiency of the final system, as well. The natural gas (optionally LPG) operated SOFC and the ZEBRA battery will be thermally integrated. Both will provide power for TLC energy stations. Basic research will be pursued on SOFC stacks to reach FCH JU targets in terms of efficiency, duration and costs. On top of these activities, detailed analyses of final proof-of-concept life cycle cost and total cost of ownership are foreseen. The thermal energy (waste heat) of the system can be applied for heating purposes as well as for cooling applying, e.g. an absorption cooling system. The system demonstration will take place at Ericsson as a real TLC site

Keywords: solid oxide fuel cell,telecom,combined heat & power,back-up power,uninterruptible power supply
Thermochemical HYDROgen production in a SOLar monolithic reactor: construction and operation of a 750 kWth PLANT (HYDROSOL-PLANT)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Greece,Germany,Spain,Netherlands
Call:  (FCH-JU-2012-1, 2012)
Start date: 2014-01-01
End date: 2018-04-30
Duration (months): 52.0
Total project cost (EUR): 3453422.16
EU funding (EUR): 2265385.0
Participants: 5
Project status: CLOSED

The HYDROSOL-PLANT project is expected to develop, verify and operate all of the tools required to scale up solar H2O splitting to the pilot (750 kWth) scale. The work will be based on the successful HYDROSOL series projects and mainly on the outcome of the current FCH-JU co-funded project, HYDROSOL-3D, dedicated to the provision of all main design specifications of such a pilot plant. HYDROSOL-PLANT comes thus as the natural continuation of such an effort for CO2-free hydrogen production in real scale. The main objectives of HYDROSOL-PLANT are to: • Define all key components and aspects necessary for the erection and operation of a 750 kWth solar plant for H2O splitting (heliostat field, solar reactors, overall process monitoring and control, feedstock conditioning, etc.) • Develop tailored heliostat field technology (field layout, aiming strategies, monitoring and control software) that enables accurate temperature control of the solar reactors. • Scale-up the HYDROSOL reactor while advancing the state-of-the-art (redox materials, monolithic honeycomb fabrication and functionalization) for optimum hydrogen yield. • Design the overall chemical process, covering reactants and products conditioning, heat exchange/recovery, use of excess/waste heat, monitoring and control. • Construct a solar hydrogen production demonstration plant in the 750 kWth range to verify the developed technologies for solar H2O splitting. • Operate the plant and demonstrate hydrogen production and storage on site (at levels > 3 kg/week). • Perform a detailed techno-economic study for the commercial exploitation of the solar process.

Keywords: solar hydrogen,monolithic solar reactor
European 450mm Equipment Demo Line (E450EDL)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Electronic Numerical Integrator and Computer
Action type: Collaborative project
Partnership: ENIAC (Art-185)
Countries involved: Netherlands,France,Israel,Belgium,France,France,Austria,France,Czechia,Austria,Hungary,France,France,Netherlands,France,Germany,Netherlands,Germany,Germany,Switzerland,Germany,Germany,Germany,Ireland,Netherlands,Germany,United Kingdom,Netherlands,Germany
Call:  (ENIAC-2012-2, 2012)
Start date: 2013-10-01
End date: 2016-09-30
Duration (months): 36.0
Total project cost (EUR): 205722560.0
EU funding (EUR): 30858386.0
Participants: 42
Project status: CLOSED

The aim of the E450EDL project is to continue the engagement of the European semiconductor equipment and materials industry in the 450mm wafer size transition that started with the ENIAC JU EEMI450 initiative and proceeded with subsequent projects funded with public money, amongst others NGC450, SOI450, EEM450PR. The demo line resulting from this project will be such that it will enable first critical process module development by combining imec infrastructure with tools remaining at the site of the manufacturers (distributed pilot line). Multi-site processing will allow partners to participate in the world first 450mm integration studies and will be enabled by the controlled exchange of 450mm wafers between different sites. The consortium comprises 43 members (from 11 different European countries) with many SMEs and research institutes. The project is organized in five technical work packages and a work package on management and coordination. In the work package on integration and wafer processing first critical modules will be developed and will demonstrate the feasibility of processing on 450mm wafers. The main objective in the work package on lithography is to develop a wafer stage test-rig, which can be implemented into the pilot line system. In the work package on front end equipment several tools will be developed such as a plasma ion implant module, a plasma dry etch module, a RTP system and a single wafer cleaning system. Furthermore, in the dedicated work package on metrology 450mm metrology tool types will be developed for amongst others dielectric film thickness and composition measurements, defect inspection, defect review and analysis, optical critical dimensions (CD), overlay (mask and wafer) and 3D metrology. Finally, from the work package on wafer handling and automation a set of equipment will be provided to support the demo line operations, and facilitate the R&D dedicated to process and metrology modules.

Keywords: demo line equipment for 450mm ic manufacturing
DEVELOPMENT OF ADVANCED GAN TECHNOLOGIES (AGATE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Electronic Numerical Integrator and Computer
Action type: Collaborative project
Partnership: ENIAC (Art-185)
Countries involved: France,France,Belgium,Spain,Austria,Austria,France,Poland,Spain
Call:  (ENIAC-2012-2, 2012)
Start date: 2013-04-01
End date: 2016-03-31
Duration (months): 36.0
Total project cost (EUR): 59638873.0
EU funding (EUR): 8839423.0
Participants: 10
Project status: CLOSED

According to the High-Level Experts Group (HLG) micro and nanoelectronics are essential for all goods and services which need intelligent control in all innovative sectors and are therefore identified as Key Enabling Technologies (KET). Gallium Nitride is an advanced semiconductor material at the heart of three strategic issues, advanced materials, photonics and micro/nanoelectronics. The deployment of these technologies is key for Europe to strengthen its manufacturing capacities while addressing societal challenges on energy and transportation. The main goal of the AGATE project is to implement an industrial European source of engineered substrates and epitaxial structures for GaN electronic devices, and to validate the substrate performances on high performance GaN devices.

Keywords: semiconductor,advanced substrates,power devices,photonics,micro&nanoelectronics,high performance,manufacturability,pilot line
QUARTERNARY STRUCTURE IMAGING WITH NANO-MAGNETIC RESONANCE IMAGING (NANO-MRI) (NANO-MRI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

There are three major problems in structure determination that can be circumvented using the proposed method. First, currently available methods such as nuclear magnetic resonance, X-ray crystallography and cryo electron microscopy require averaging over thousands of identical molecules at least. Second, X-ray crystallography and cryo electron microscopy lead to radiation damage of the sample. Third, NMR and X-ray crystallography are limited to a certain molecular size or shape. Magnetic Resonance Imaging (MRI) is an attractive alternative since it is non destructive, has elemental contrast and is possible for single particles. However, conventional MRI has only a few microns resolution. Magnetic resonance force microscopy, the method this proposal is based on, combines the principle of MRI with scanning force microscopy and thus pushes the limits of resolution down to the nanometer range. I will add domain contrast and push the limits of resolution further by introducing partial labeling. I will test and apply this entirely new concept to tobacco mosaic viruses. That will lead to a 3D protein structure with domain contrast with nanometer resolution from a single virus particle. This method is especially promising for large, rare or heterogeneous proteins that cannot be analyzed with state of the art methods.

Keywords: magnetic resonance imaging,structural biology,mrfm,virus
Chromium free surface pre-treatments and sealing of Tartaric Sulphuric Anodizing (CHROMFREE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Austria
Call:  (SP1-JTI-CS-2012-02, 2012)
Start date: 2013-03-01
End date: 2015-06-30
Duration (months): 28.0
Total project cost (EUR): 150000.0
EU funding (EUR): 112500.0
Participants: 2
Project status: CLOSED

Corrosion of Al has to be counteracted by first anodizing the Al parts and applying further protective coatings. Anodized aluminium is normally further processed with a sealing as a final step after anodizing. A hot water sealing process is one of the widely used methods. However in order to close (seal) the pores in the aluminium oxide anodized layer for corrosion protection a process involving boiling water containing chromate is still commonly used. Cr(VI)-based sealing solutions have been employed for several decades, but remain one of the most effective and commonly-used methods to improve corrosion resistance of anodized aluminium. Alternative sealing methods have also been proposed for example with Ni(II), Co(II), Ni(II) and Co(II), rare earth salts alkali metal fluorides, alkanolamine salts of phosphonic acids, Cr(III), fatty acids, silicates, etc. Kendig and Buchheit indicate that 45 of the 92 naturally occurring elements have been considered as replacements for Cr(VI) in conversion coatings on aluminium. In general these approaches have not been as successful as the Cr(VI) sealing. Also it should be noted that Ni(II), Co(II) and fluorides are not without health implications, whereas most organic molecules would be expected to have limited lifetimes under the extreme conditions (UV radiation, low pressure, large temperature range) experience by commercial aircraft during operation. Therefore, of the previously identified approaches Cr(III)-containing or silicate-forming sealing solutions are preferred options. Encouraging results were obtained with deposition of films of CeO2.2 H2O on aluminium alloys in a few minutes at room temperature with or without catalyst, though the performances still do not equal those of CCC. Detailed investigations and characterization of the obtained will be performed. The optimized sealing and pre-treatments process will be applied to a flat test panel of 384 x 742 mm.

Keywords: chrom free,anodization,sealing,tsa,demostrator