Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Resilient and environmentally sustainable engineered crops to address climate change (Crop4Clima)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel,Germany,Italy,Bulgaria
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-05-01
End date: 2025-12-31
Duration (months): 32.0
Total project cost (EUR): 2475562.5
EU funding (EUR): 2475562.5
Participants: 4
Project status: SIGNED

Current global warming, caused by anthropogenic emissions of greenhouse gases (in particular CO2), is expected to rise from 2.5°C to 4°C by the end of the century. Consequently, agriculture is faced with the urging needs of increasing CO2 sequestration, coping with adverse weather and disastrous events, (ie droughts, heat waves, fire and flooding) and feeding an ever-growing world population projected at 9.7 billion in 2050. Future crops must serve as more efficient carbon sinks to mitigate climate change, plus have higher resilience and productivity to feed the global population. Crop4Clima will develop first-of-a-kind canola and rapeseed lines able to assimilate 60% more CO2 through photorespiration, requiring 20% less amount of water, improving biomass/Ha and still maintaining high oil content values as required for canola derived products. No commercial crops of that kind exist. To reach such product, we will improve and bring to commercial use, a disruptive synthetic metabolic pathway, the TaCo pathway, which turns photorespiration into a CO2-fixing instead of a CO2-releasing process, leading to increased net carbon-uptake under agronomical standard and drought field conditions. Canola and rapeseed are major crops in EU and worldwide. Notably, our technology has commercial prospects to be introduced in other C3 crops such as soybean, cotton, rice and more, based on photosynthetic and genomic similarity. The success of the technology implementation in rapeseed will allow us to establish a start-up seed company aiming to produce and sell high oil seeds with low carbon footprint. In addition and in frame of the program we will develop an innovative business plan taking into considerations how the food value chain is evolving to cope with food supply and climate change signing a precommercial agreement with our industrial partners for the development of our engineered crops up to TRL9 and build trust on the solution proposed.

Keywords: synthetic biology,metabolic engineering,photorespiration,photosynthesis,c sequestration in plants
Production of High-quality Fatty Acids Feedstock for use in SAF Production (GAFT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-07-03
End date: 2025-07-02
Duration (months): 24.0
Total project cost (EUR): 4025965.76
EU funding (EUR): 2499999.0
Participants: 2
Project status: CLOSED

COVAL's GAFT project presents two innovations in biofuel production processes, for Formic Acid & for Fatty Acid, both essential for future sustainable aviation fuel. Our patented process to produce potassium formate (PF) out of CO2, water, and renewable electricity enables a higher concentration to be produced using conventional equipment. We then convert this PF to formic acid (FA). We have also developed a non-GMO microorganism that uses FA (and glycerol) as a substrate to produce fatty acids. These fatty acids are used as feedstock for HEFA to produce Sustainable Aviation Fuel (SAF). The remaining biomass by-product is a crude microbiological protein that can be used as aquafeed. GAFT dramatically improves the production of SAF by being more energy efficient, using just enough energy to produce a C1 hydrocarbon from CO2 and subsequently, via fermentation, to produce fatty acid feedstock for the only currently available commercial technology to produce SAF, the HEFA process.

Keywords: bioprocessing technologies industrial processes r,energy systems production,distribution,applicat,industrial bioengineering,environmental and green technologies,bioenergy,biofuels,bioproducts products that are manufactured using,environmental protection
Low-coSt and energy-efficient hybrid Photonic integrated circuits for fibeR-optic, free-space optIcal and mmWave commuNication systems supporting Time critical networking in industrial EnviRonments (SPRINTER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Greece,Germany,Italy,Austria,Switzerland,Netherlands,Belgium,Spain,Israel,Finland
Call: Advanced optical communication components (Photonics Partnership) (IA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 7112455.75
EU funding (EUR): 5999935.0
Participants: 13
Project status: SIGNED

SPRINTER will provide a set of low-cost, energy-efficient, and ultra-dynamic optical transceivers and an optical switching solution to cope with the diverse needs of the industrial networks and expedite their truly digital transformation. SPRINTER will combine the best-of-breed optical components and methods from various powerful but complementary photonic integration platforms to develop low-cost and energy-efficient 200 Gb/s optical transceivers, and ultra-fast wavelength-tunable 10 Gb/s optical transceivers. Leveraging well-proven integration techniques that allow for the fabrication of complex 3D photonic integrated circuits, the project will provide a disruptive low-loss and polarization-insensitive reconfigurable optical add-drop multiplexer, optimized for operation within space-division multiplexing networks. Considering the ultra-dynamic nature of the industrial networks due to the deployment of either temporarily fixed or moving remote nodes, SPRINTER will provide a set of groundbreaking photonics-enabled transceivers supporting wireless connectivity by means of a free-space optical or a mmWave channel. The transceivers will be able to operate reliably in indoor environments, as well as, outdoor environments thanks to the complementary characteristics of the two channels. The project will also develop a unified network platform, providing the required methods and tools to support time-deterministic operation, and enable real-time communication with guaranteed service quality. In order to showcase SPRINTER's full potential, the developed technology will be evaluated within application scenarios that will be deployed in a relevant industrial environment incorporating a fully operational closed-loop control system.

Keywords: photonic integrated circuits,externally modulated laser arrays,vertical cavity surface emitting laser arrays,ultra fast tunable external cavity laser source,space division multiplexing network
The biofabrication of a 3D in vitro human oviduct model to study infertility and factors affecting embryo development (OviChip)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2318530.0
EU funding (EUR): 2318530.0
Participants: 1
Project status: SIGNED

Despite being viewed as a simple transport conduit, the oviduct can determine a successful pregnancy and has a life-long impact on our health and wellbeing. Also called the fallopian tube, our understanding of tubal function remains limited, owing to the ethical limitations of human studies and the poor translations of animal studies to people. The objective of the OviChip project is to create the first full-scale 3D in vitro model of the oviduct that can address our knowledge gap. The oviduct selects healthy sperm and hosts the first embryonic cell divisions, setting the stage for fetal development and health in our adult life. Epigenetic factors can trigger genetic defects in these first moments that lead to unsuccessful pregnancies or ailments such as Alzheimer’s, Diabetes, and schizophrenia. When oviduct function is compromised, such as through a Chlamydia Trachomatis infection, infertility can arise. A common recourse for prospective parents is in vitro fertilization (IVF). However, IVF success rates have plateaued at 30% for the past decade and concerns have emerged about the epigenetic impact IVF has on a child’s health. Therefore, to improve embryo viability and IVF outcomes or to avoid IVF by addressing tubal pathologies, our knowledge gap about oviduct function must be addressed. The OviChip project will develop biofabrication technologies to create a 3D model that respects the structural and biological elements of the oviduct from a meso to micron scale. The anticipated outcomes include: 1) the validation of new biofabrication approaches; 2) a better understanding of Chlamydia-associated tubal pathologies; 3) insight into the oviduct microenvironment with respect to sperm selection and epigenetic factors affecting embryogenesis. The OviChip will strive for unprecedented biomimicry and functional readout, setting new standards for tissue engineering. Most importantly, this will provide a unique avenue to fundamental answers that impact patients.

Keywords: 3d cell culture,tissue engineering,in vitro model,biofabrication,oviduct,reproduction,infertility
Heterogeneities-guided alloy design by and for 4D printing (HeteroGenius4D)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 1499999.0
Participants: 2
Project status: SIGNED

Superior high-performance materials and CO2-free production technologies are key enablers to solving Europe’s current and future societal challenges [1]. In this context, additive manufacturing (AM) as one of the disruptive, green production technologies of our time “is expected to become a key manufacturing technology in the sustainable society of the future” [2]. However, alloys specifically designed for AM are rarely available, which prohibits AM from reaching its full potential. In contrast to conventional alloys and processing, alloys processed by AM are highly microstructurally heterogeneous. It is the aim of HeteroGenius4D to use the process-inherent conditions of highly precise, bottom-up AM approach to tailor these heterogeneous structures (e.g. grains/phases and their boundaries and orientations, chemical gradients, etc.) locally and spatially on various length scales. This is the basis for the novel design concept of heterogeneities-guided alloy design for AM. The potential to print local microstructures and properties in AM adds a 4th dimension to the design of 3D printed components; i.e. enables 4D printing. AM-processed metals with increasing degree of heterogeneity (from pure element over solid solutions with chemical gradients to multi-phase alloys with further phases and gradients) are studied systematically. The process-structure-properties-performance linkages are identified and quantified by combining high-throughput material synthesis (using extreme high-speed laser material deposition) and characterization with physics-based simulation tools, enabling a comprehensive integrated computational materials engineering (ICME) framework. The generated data serves as a basis for sophisticated data-driven (machine learning, ML) materials modelling and enables the establishment of an Experiments-ICME-ML optimal design approach for metal AM. Finally, the concept of heterogeneities-guided alloy design is generalised and transferred to graded components.

Keywords: materials science,high performance alloys,additive manufacturing,microstructure,plasticity,design,integrative computational materials engineering,machine learning,experiments
Echoes of Rome: Deciphering Hispania’s Coinage Origins with Lead Isotope Analysis (ECO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Canada
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2029-02-28
Duration (months): 36.0
Total project cost (EUR): 318138.72
EU funding (EUR): 318138.72
Participants: 2
Project status: SIGNED

The analysis of lead isotopes in Roman coins has gained significant popularity in recent years. Several ERC-funded projects provide clear evidence of the scientific interest in ancient coins and their isotopic results. Today, lead isotope analysis is the most effective method for establishing the geographical origin of lead present in ancient metals or coins. The project “Echoes of Rome: Deciphering Hispania’s Coinage Origins with Lead Isotope Analysis” is based on this multidisciplinary approach. Despite these advancements, the supply of metals to Roman provincial cities for minting bronze coins remains a mystery, and a holistic view has yet to be addressed. Through the ECO project, I will analyze the provincial bronze coinage of Hispania. Additionally, the lead isotopic results obtained by MC-ICP-MS will be compared. This comparison will provide a solid foundation for future research. The progress achieved in terms of origin, supply, and distribution will be highly regarded by scholars. Furthermore, the combined use of epigraphic and archaeological sources, along with new data provided by isotopic analysis, will enhance our understanding of the economic history of the Roman Empire, particularly Hispania, one of the most prosperous and significant regions of the Mediterranean. Finally, the archaeological and mining context of Hispania and its development are of paramount importance to the Roman Empire. The mining areas of Cartagena-La Unión and Linares-La Carolina were, for decades, Rome’s main source of silver.

Keywords: numismatics,ancient coins,roman coinage,bronze coins,roman mining,metal supply
CD22/CD19 dual redirection Dual targeting of CD22 and CD19 with BiTE-secreting and CAR-expressing bispecific T-cells for adoptive Cellular ImmunoTherapy in advanced B-cell Acute Lymphoblastic Leukemia (BiTE-CAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-07-01
End date: 2025-03-31
Duration (months): 21.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Anti-CD19 immunotherapies based on Bi-specific T-cell Engagers (BiTE) or chimeric antigen receptor (CAR)-expressing T-cells have revolutionized the treatment of refractory/relapse (R/R) B-cell acute lymphoblastic leukemia (B-ALL). However, despite initial impressive complete response (CR) rates, many patients relapse few months after anti-CD19 immunotherapy; in many cases with CD19 antigen loss. Such relapses are devastating, and patients are left with virtually no further treatment options. Dual targeting of the pan-B antigens CD19 and CD22 has been proposed as a therapeutic strategy to distribute the antigenic pressure over two molecules and to reduce immune escape by covering practically all B-ALL blast subclones. CD19/CD22-directed dual CARs have in fact been proposed to overcome B-ALL immunoediting during CAR T-cell therapy but, unfortunately CD19/CD22 dual CAR-treated R/R B-ALL patients showed CR rates not sustained over time and relapse with limited CAR T-cell expansion. In contrast to CAR T-cells, BiTEs-secreting T-cells represent a unique strategy capable of redirecting bystander T-cells to tumor cells because T-cell-produced BiTEs will be continuously secreted and will decorate, through the CD3scFv, the cell surface of practically all circulating and ex vivo manufactured bystander T-cells. Our overarching goal is to provide a novel and innovative T-cell redirecting immunotherapy for the treatment of R/R B-ALL by dual targeting both CD22 and CD19 with T-cells modified to simultaneously secrete CD22xCD3 BiTEs and express CD19 CAR (referred to BiTECAR). This strategy harnesses the biological advantages of both CARs and BiTEs while minimizing their limitations and will circumvent the potential low transduction efficiencies of the BiTECAR construct because the CD22-BiTE secreted by transduced T-cells will decorate the bystander (untransduced) T-cells boosting the durability and strength of T-cell responses.
Novel targeted Intervention to Treat Anemia (NITA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Anemia, defined as a decreased quantity of circulating red blood cells, is a major source of morbidity and mortality affecting a-third of the worldwide population. As a functional component of erythrocytes hemoglobin, iron is essential for oxygen storage and transport. The liver-derived peptide hepcidin is the master regulator of iron homeostasis. During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure the proper supply of iron to the bone marrow for red blood cells synthesis. However, we provided evidence that another factor may exert a similar function. We identified a previously undescribed suppressor of hepcidin that is highly induced in the liver in response to hypoxia during the recovery from anemia and in thalassemic mice. We demonstrated that this hepatokine is a potent suppressor of hepcidin in vitro and in vivo. Our aims is to investigate the therapeutic potential of its manipulation in murine models of anemia. Successful completion of this project will lead to the development of new therapeutic strategies for the treatment of various forms of anemias for which current treatments remain largely ineffective.
Panel Recycling and Integrated Solar Material (PRISM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 2978538.58
EU funding (EUR): 2084977.0
Participants: 1
Project status: SIGNED

IRENA (2016) estimates that the cumulative PV panels waste volumes will reach 78M tons by 2050 (8M. tons by 2030). PV panels contain silver and silicon, which if recycled, represent a source of valuable and critical raw materials for the energy transition ($80B by 2050). Today, many recycling facilities only recover bulk materials like aluminum frames and low-quality front glass. The remaining material is often incinerated, disposed, or down-cycled, even though it contains silver and silicon, which together account for two-thirds of the monetary value of a silicon PV panel’s materials. To take advantage of this opportunity, SOLAR MATERIALS has developed a patented layer-by-layer thermo-mechanical recycling process based on infra-red heating to de-laminate and recover all valuable raw materials contained in PV panels. SOLAR MATERIALS’ recycling process is the 1st in the world to recover all raw materials from solar modules in an economical and energy-efficient way. This enables us to achieve the highest profitability in the industry (EBITDA margin of 50%), even with recycling fees at 50% lower of that of current prices. Solar park owners (Enerparc) and leading metal smelters and refineries in Europe (Stemin, Umicore) have already formally expressed their interest in our recycling services and material products. Moreover, we have validated our sales prices with quotes and analysis for glass (PreZero, Reiling), copper cables (Remondis), aluminum (Stemin, Hydro), silver (Umicore) and silicon (Circular Silicon). With this project, we will setup and operate an industrial-sized commercial PV module recycling plant in Germany with capacity to process 8,400 tons of PV panel waste per year. By 2033, we expect to own and operate 33 recycling facilities globally, with a cumulated annual capacity of 277M tons. By then, we would have recovered 710 tons of silver, 46,381 tons of silicon, and 215,237 tons of aluminum, accounting for over 4.5M tons of avoided CO2-eq emissions.

Keywords: photovoltaic modules,physical mechanical processes,recycling,silicon,silver,solar energy,infra red heating