Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New full-electric propulsion system, completely submerged in water, for zero-emissions navigation (Full Electric Boats)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The goal of our project is to launch on the boating market a zero-emissions propulsion system that can be installed on boats up to 10-12 metres long. This goal will be reached by developing an electric propulsion system that is completely submerged in water. With its wide range of power (10-25-50 Kw) and high endurance (over 2 hours), it will be able to be installed on both pleasure craft and passenger boats. The strength points of our solution will be: - integration of motor, propeller and power-assisted steering into a housing submerged in the water. This latter feature is particularly important, since it significantly simplifies the mechanical design of the motor, which will no longer require a cooling system. The unit will be particularly compact, so the technology can be used even on small to mid-sized boats; - an operating endurance that can be varied to meet the individual requirements of final users by having the option of installing batteries that are more or less powerful and which can even be supplemented with other energy production technologies such as photocells, mini-wind power and a small endothermic generator for emergency use. The new propulsion system drives the propeller shaft directly. No reduction gear is used, thus mechanical losses are eliminated. A sophisticated software control system will be developed to allow manoeuvres in tight waterways, even using a joystick. More precisely, when two motors are installed in parallel, the system will allow each motor to turn independently, thus allowing lateral movement that would not otherwise be possible. To further enhance the project, a BMS (battery management system) has been specifically developed to control the batteries. We plan to offer a solution that fully meets the needs of the market regarding boats up to 10-12 metres, which consists of more than 63,000 new boats sold every year and which totally produce approx. 113,000 tons of CO2.

Keywords: zero emission propulsion,electric propulsion,high endurance,wide power range,manoeuvres in tight waterways
Fully-automated software platform with 3D freeform configurator for design and production of individual and affordable furniture (3DConfigurator)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 2702500.0
EU funding (EUR): 1891750.0
Participants: 1
Project status: CLOSED

Mass customization is finding its way into innumerable areas of daily life, e.g. textiles, shoes, as consumer strive for individuality. 84 million customers bout furniture online in the EU. The preconditions for mass furniture are enabled by digitization. Yet there is no solution for affordable individualized furniture representing a tremendous unexploited market. FORMBAR, our novel parametric design software based on mathematical-physical-architectural principles, is the enabling technology allowing customers for the first time to freely shape their furniture individually. In this Phase 2 project FORMBAR will be 100% automated. With simple mouse movements, the customer designs a photo-realistically rendered 3D model and thus constantly inspects his created piece of furniture visually with regard to the selected materiality and colour. By directly integrating the machine specifications into the design process, the self-generated 3D piece of furniture is automatically converted into an optimized cutting pattern and produced cost-effectively using state-of-the-art CNC milling machines. The generated milling data are sent to one of the more than 100 carpenters of OKINLAB in close vicinity to the customer. FORMBAR covers the entire furniture manufacturing process 100% automated, from design to production, in a single application. In combination with mathematically implied algorithms, OKINLAB can guarantee the functionality as well as the producibility of the furniture while at the same time implementing a scalable business model. With FORMBAR mass customization of individual furniture becomes affordable for the first time. OKINLAB with its team of 16 employees from software development, architecture, design, marketing, has developed a configurator in the past selling more than 1,500 pieces of furniture as of today. By automation of FORMBAR costs of the furniture is reduced by 50% opening the technology for the mass market with a potential of €25.3 billion.

Keywords: freeform furniture,e commerce,milling data,carpenter,automated data generation,configurator,web platform,timber,automated conversion,interactive design,virtual model
Risk and Migration A Transnational History of Romanian Migration to Western Europe (2002-2013) (TransHI-Rom)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The liberalization of border controls following the breakdown of the Europe's communist regimes led to important flows of East-West migration. Western Europeans, fearing a literal invasion of Central and Eastern European immigrants, increasingly interpreted this new-found mobility as being fraught with risk. This research project will examine the history of Romanian migration to France and Italy from 2002 until the end of 2013 from the perspective of risk. It will analyse how evaluations of and responses to risk shape the migration process. The first step of this project will be to understand how fear of migration influences political responses and regulatory measures. The second step will investigate how this sense of fear developed and evolved within French, Italian and Romanian societies. It will also analyse how risk perception impacts migrants’ relationships with the host society. Focussing on the migrants’ own perceptions of their mobility, the third step of the project will examine how they respond to risk. An emphasis will be placed on young adults. The inter-disciplinary perspective adopted in this study will provide a more complete history of Romanian migration during the last decade. Drawing on empirical research, this study will focus on the connections that could be established between European citizens. The final objective is to demonstrate the relevance of ‘risk’ in understanding the migration process.

Keywords: romanian migration,transnational,risk perception,risk assessment,intra european mobility
Synthetic Oxygen-related molecular Systems in plants (SynOxyS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1999995.0
EU funding (EUR): 1999995.0
Participants: 1
Project status: SIGNED

Aerobic organisms developed systems to measure cellular oxygen levels and activAerobic organisms developed systems to measure cellular oxygen levels and activate adaptive responses in case hypoxia occurs. This condition can be caused by sudden environmental changes or associated with developmental programmes. Recent reports have revealed that complex eukaryotes, such as plants and animals, converged towards the recruitment of dioxygenase enzymes to regulate gene targets at the transcriptional level. However, while the sensing strategy is the same, the molecular identity of the components involved is different. The similarities and differences between animal and plant hypoxia machineries can be exploited to acquire better understanding of the dynamics of oxygen sensing in the two kingdoms and more precise manipulation of these mechanisms for farming proposes. Here, I plan to apply a novel approach that merges the synthetic biology framework, molecular physiology and developmental biology to transfer features of the metazoan oxygen sensing and delivery systems to plants. This strategy will be instrumental to investigate for the first time whole oxygen machineries and characterize their performance in the context of plant cells. More specifically, the proposed project expands in three distinct although interlinked directions that explore (1) the exploitation of 2-OG dioxygenase to drive selective proteolysis in higher plants, (2) the investigation of endogenous or heterologous control of chromatin accessibility by 2-OG dioxygenases and (3) the engineering of a synthetic delivery delivery system to alter oxygen provision or perception specifically to shoot apical meristems. The process of design and optimization of these synthetic oxygen machineries, and the comparison with endogenous ones, will allow pinpointing the features that enable efficient control of hypoxic responses and specifically controlling adaptive responses that ameliorate hypoxia tolerance in plants.

Keywords: oxygen,hypoxia,selective proteolysis,synthetic biology,oxygen delivery,flooding,camelina sativa,arabidopsis thaliana,shoot meristem development
Characterization and implications of DNA damage response in liver cancer (EpiLIVER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-01-14
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Cholangiocarcinoma (CCA) is a devastating type of liver cancer that presents late, is difficult to diagnose and associated with a high mortality. Although worldwide the epidemiological trend is mixed, in the EU it has been steadily increasing for the last decade. Treatment is limited to tumor resection, which is not applicable in the vast majority of cases. The lack of any approved chemotherapy-based treatment is partially due to the poor understanding of the molecular mechanisms involved in the response to these drugs. Taking advantage of the comprehensive panel of established and primary CCA cell lines in the host PI’s lab and my expertise on the DNA damage response (DDR) and repair field, my proposal offers a new approach in this scenario by characterizing the DDR of CCA cells. This study will be focused on the DDR-related chromatin remodeling SWI/SNF complex. In recent works, mutations in this family of proteins were identified in 47% of all CCA cases analyzed through whole exome sequencing, hence providing a relevant rationale in studying this complex. First, I will identify candidate markers of all known components of the SWI/SNF complex, based on RNAi high-throughput analysis. I will then perform direct and quantitative measurements of the DNA repair activity in CCA cells, specifically related to homologous recombination repair (HR) by rapid and sensitive reporter assays. And lastly, I will determine the proteome dynamics in the CCA context. There are two exclusive novelties on this approach: (1) the described novel methods will be employed in the Hepatology field for the first time; and (2) the use of primary CCA cells will enable me to directly compare observations in culture with clinical outcome. This proposal will not only contribute to the understanding of a limited understood area in liver cancer, but also holds great promises for future clinical use, where DDR-based drugs are the clinical mainstay

Keywords: cholangiocarcinoma cca,rnai screening,dna damage response ddr,homologous recombination hr,snf complex,drug treatment
A modular and compact controller design for light electric vehicles (Adaptcontrol)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 2042725.0
EU funding (EUR): 1429907.5
Participants: 1
Project status: CLOSED

Electro-mobility is one of the keys to achieve European objectives to reduce emissions and to halve the number of conventionally-fuelled vehicles by 2030. Having identified the huge opportunities within the Electric Vehicles market, our company Bultaco Motors has revealed two all-electric motorcycle prototypes in May 2014 that will point the way forward in the electric motorcycle market. Supported by our excellent team, we have developed the whole power-train in-house. In the project Adaptcontrol, Bultaco Motors will go a step further and re-engineer an industrial solution of the currently used controller within the power-train with a solid performance at a competitive cost as well as validate the controller in fully operational environment and working conditions. Adaptcontrol aims at developing an enhanced version of the currently existing controller with a focus on: Volume reduction (-20% compared to the currently existing controller), weight reduction (- 13%), reduction in production cost (- 50%), and the development of a modular and adaptive design. These improvements will lead to system advantages compared with current solutions that will ensure Bultaco Motors a considerable market share and leadership not only in the electric motorbike market but also in the growing European and worldwide market for electric vehicle controllers specific for light traction applications that has shown a steady growth rate in 2012 of 11% . Adaptcontrol aims to position Bultaco Motors as a reference world-wide supplier for smart vehicle control systems with overall energy management and recovery capabilities. The power control unit modularity, dimensions and operation configurations will allow any OEM engineer to adapt it to a wide range of electric vehicle types such as the formerly mentioned ones. In such applications, where reduction of weight and volume is so important, having a unique unit for the entire vehicle control makes integration easier and more space effective.

Keywords: light electric vehicles,motorbikes,controller,power train
Research with and for society in EUNICE (REUNICE)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Belgium,Finland,Poland,France
Call: Support for the Research and Innovation Dimension of European Universities (Part II) (H2020-IBA-SwafS-Support-2-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 1997875.0
EU funding (EUR): 1997875.0
Participants: 7
Project status: SIGNED

REUNICE is a strategic project for the European Universities Alliance EUNICE which aims to align its education, research and innovation strategies through an ambitious and transformative agenda. This agenda is trans-disciplinary, intercultural, shared, and provides a long-term joint strategy for a ‘customized’ university. Becoming a true European university through REUNICE will support the efforts of the Alliance to contribute to the development of a society based on knowledge and innovation, also considering smart, sustainable and inclusive growth. The implementation measures proposed aim to provide concrete life experiences for the university community as a whole. Individual experiences are focused on the development of personal attitudes such as openness and sensitivity to individual and community particularities. Institutional experiences contribute to institutional change that guarantees inclusiveness and forward-facing principles for the Alliance members. To achieve this ambitious goal, REUNICE is building cooperation between Science and Society, recruiting new talents for science and pairing scientific excellence with social responsibility. Cooperation with non-academic actors, mainly academia-business cooperation, will be reinforced. The scientific community, industry, professional organizations, policy makers, civil society and public authorities will be involved in exploring and supporting citizen science through the Alliance Competence Center, a pilot initiative clustering activity to share best practices, research infrastructures and innovation resources. REUNICE will allow the alliance to develop an ambitious common research and innovation agenda and action plan that, in turn, will address the societal challenges identified by the H2020 programme. It will contribute to the consolidation of EUNICE through the improvement and extension of the academic and research networks that have already been initiated through the activities of the Alliance.

Keywords: randi strategies,synergies,societal challenges,open science,excellence in research,science for citizen and society,inclusiveness,gender equality,sustainable science,artificial intelligence
Multi Ion Reflection Apparatus for Collinear Laser Spectroscopy of radionuclides (MIRACLS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 1463750.0
EU funding (EUR): 1463750.0
Participants: 1
Project status: CLOSED

Employing laser spectroscopy (LS) to study radionuclides is equally rich in its long tradition as it is manifold in its active pursuit today as virtually all radioactive ion beam (RIB) facilities do or are planning to host dedicated setups. Probing the hyperfine structure of an atom or ion with laser light is a powerful technique to infer nuclear properties such as a nuclide’s spin, charge radius, or electromagnetic moments. This information provides insight into a wide range of contemporary questions in nuclear physics such as the mechanism driving the emergence and disappearance of nuclear shells far away from stability. In the last decade, LS has benefited from the advent of ion traps in rare isotope science. The bunched beams released from these traps have led to an increase in sensitivity by several orders of magnitude due to an improved signal-to-background ratio when gating on the passing ion bunch. This present proposal is determined to introduce another type of ion trap, an Electrostatic Ion Beam Trap, which has the potential to enhance the sensitivity of collinear LS by another factor of 20-800. This is achieved by increasing the laser-interaction and observation time by trapping the ion bunch between two electrostatic mirrors while keeping its beam energy at 30 keV to minimize Doppler broadening. Such a device promises to extend collinear LS to nuclides so far out of reach given their low yields of typically <1000 ions/s at RIB facilities. Among the accessible nuclides are 34Mg in the island of inversion, 20Mg at the neutron shell closure N=8, or Sn isotopes towards the doubly magic 100Sn. Their charge radii will benchmark modern theoretical models utilizing 3-body forces in their quest to understand the evolution of nuclear shells. Ultimately, the setup can be further enhanced in sensitivity when combined with other single-particle detection methods or by utilizing its multi-reflection time-of-flight aspect to suppress disturbing isobaric contamination.

Keywords: laser spectroscopy of short lived nuclides
Self-amplified photonic biosensing platform for microRNA-based early diagnosis of diseases (SAPHELY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Austria,Spain,Germany,Germany,Sweden,Denmark,United Kingdom,United Kingdom
Call: Photonics KET (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-07-31
Duration (months): 42.0
Total project cost (EUR): 3228838.0
EU funding (EUR): 3228838.0
Participants: 9
Project status: CLOSED

The SAPHELY project focuses on the development and the preclinical validation of a nanophotonic-based handheld point-of-care (POC) analysis device for its application to the minimally-invasive early diagnosis of diseases, with a focus in cancer. Disease identification will be based in the fast (<5 minutes), ultra-sensitive (sub-pM) and label-free detection of novel highly-specific microRNA (miRNA) biomarkers, using a small volume of whole blood (<100 μL). This POC analysis device, which will have a low cost (envisaged cost < €3000), will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates. The ultra-high sensitivity required for the direct detection of miRNA biomarkers present in the bloodstream will be achieved by using a novel sensing amplification technique. This technique is based in the use of molecular beacon capture probes with an attached high index nanoparticle, so that the hybridization events are translated into the displacement of these nanoparticles from the sensor surface. The use of this self-amplification technique avoids the use of complex PCR-based amplification methods or labelling processes, which are difficult to implement on-chip. The cost, size and weight reduction required for deploying an affordable handheld POC device will be achieved by using a novel power-based readout scheme for photonic bandgap sensing structures where the use of expensive, bulky and heavy tuneable lasers and spectrometers is avoided. Special attention will be paid within the SAPHELY project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.

Keywords: photonic biosensor,microrna,molecular beacon,early diagnosis,in vitro diagnosis,mass screening,point of care,lab on a chip,cancer,preclinical validation