Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Engineering of Nitric Oxide Based Therapeutics for Triple Negative Breast Cancer Training Network (NO-CANCER-NET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Italy,Denmark,Spain,Luxembourg,France,United States,Canada,Netherlands
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 2736849.6
EU funding (EUR): 2736849.6
Participants: 18
Project status: SIGNED

NO-CANCER-NET will focus on Triple Negative Breast Cancer (TNBC) and Nitric Oxide (NO)-related therapeutic development. TNBC accounts for 10-20% breast cancers and is characterised by diagnosis at an early age and an aggressive phenotype. It indeed develops incurable distant metastasis within the first 2-3 years in approximately 30% patients. Despite significant efforts, TNBC treatment is limited to surgery and chemotherapy laying bare the urgent need for new targeted therapeutic development. Our network has demonstrated an important role for inducible nitric oxide synthase (iNOS) and NO signalling in TNBC metastatic progression, with efficacy of iNOS targeting demonstrated in a phase I/II clinical trial of patients with distant metastasis. Based on NO’s yin/yang effect on tumour biology, iNOS/NO system can be targeted by either inhibiting iNOS and reducing the physiological levels of NO which drive tumour progression, or vice versa using NO donating drugs to increase NO to tumouricidal levels (similar to immune cells NO-mediated tumour targeting). The NO-CANCER-NET Doctoral Network (DN) addresses two fundamental gaps in European training: 1) a network where a core of Doctoral Candidates (DCs) can share a basic understanding of molecular target discovery, models of tumour biology assessment, drug synthesis and delivery, developing diagnostics, handling complex spatial imaging and omics expression data profiles; and 2) solid interdisciplinary training in experimental, computational and clinical research. NO-CANCER-NET will equip our DCs to understand the complexities of bench to bedside cancer research, the importance of an interdisciplinary approach and an understanding of the fundamentals of related disciplines. This will be of great importance in preparing DCs to work between academia, industry and in clinical healthcare providers.

Keywords: nitric oxide,hydrogels,drug delivery,triple negative breast cancer,targeted therapeutics,3d tumour models,engineering models
JOSEPHSON GATED TRANSISTORS AND ELECTRONICS (JOGATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Finland,Germany,Sweden,France
Call: Low TRL research in micro-electronics and integration technologies for industrial solutions (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 3998787.25
EU funding (EUR): 3998787.25
Participants: 5
Project status: SIGNED

Improving the energy efficiency of densely-integrated electronic is an important goal towards the sustainability of modern digitally-connected society, in particular for what concerns high-performance computing datacenters. An important piece of the solution is found in the contacts between metallic leads and the semiconducting channels that constitute the core of transistors, the key active component in integrated circuits. A significant part of increasing the energy efficiency is tied to managing the resistance that appears between metals and semiconductors: the contact resistance. In JOGATE we utilise the unique superconducting properties in hybrid superconductor-semiconductor components to uncover the mechanisms contributing to the contact resistance and thereby improve it. In doing so, not only we contribute to solving a major obstacle for the energy efficiency of established digital electronics, but we obtain the superconducting analogues to the conventional transistors and diodes. These superconducting components are unique in that they enable new avenues for superconducting circuit design, resulting in opportunities in miniaturisation, performance and cost of devices that find application in communication, sensing and detection, signal amplification and routing. In JOGATE we wish to study superconducting transistors and diodes and to upgrade their fabrication processes to be compatible with the methods of large-scale integration, making it possible for Europe to lead their industrial production. In parallel, we contribute to finding ways of improving their performance, to ease practical adoption and impact in areas ranging from cryogenic electronics to demanding environments such as space applications. Finally, to demonstrate the value of the technology and to deliver important outcomes in the short-term, we develop two prototype devices for cryogenic microwave signal management: a radiofrequency switch and an integrated superconducting qubit control chip.

Keywords: contact resistance,josephson field effect transistor,superconducting diode,energy efficiency
Relooking at Statutory Rape Laws in Malaysia: Psychosocial Characteristics of Sexual Relations among Underage and Adult-Child Partners, Sexual Motives and Perception of the Criminal Justice Personnel (LAWS-TEENS-SEX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: CLOSED

Statutory rape laws are designed to protect children from the manipulation of adults into having sexual intercourse. However, in Malaysia, statutory rape laws are applied even on male adolescents who are close in age with their female partners. This is problematic because applying these laws into male children will criminalize their normative sexual behaviors which has long-lasting damaging effects. In addition, the perception of the criminal justice personnel on sexual behaviors of children also cements the blanket applications of statutory rape laws onto every case involving female children. To reform the use of statutory rape laws in Malaysia, data on the sexual relations between close-in-age partners and adult-child partners are needed. This study has three research objectives. First, I aim to explore the perception of the criminal justice system personnel (i.e., prosecutors, police officers and probation officers) towards the implementation of statutory rape laws on adolescents in Malaysia. Second, I would like to investigate the psychosocial characteristics (sexual and antisocial dimensions) of sexual relations involving two close-in-age children in comparison with sexual relations involving adults and children. Lastly, I aim to explore the psychosocial-cultural motivations behind the pursuance of sexual relationships among Asian adolescents. The design of the proposed study will be a mixed design, employing both quantitative (to achieve research objective 2) and qualitative (to achieve research objective 1 and 3). For the quantitative part of the study, a hypothesis will be tested which is: Close-in-age sexual partners differ in terms of psychosocial characteristics compared to adult-child sexual partners. This will be tested using a binary logistic regression. Then, I will employ a thematic analysis to find out the patterns from the responses. The findings of this project will be disseminated through two journal articles and a conference attendance.

Keywords: statutory rape laws underage partners sexual behaviours psychosocial characteristics,criminal justice system sexual motives
An European and Ibero-American approach for the digital collection, analysis and dissemination of folk music (EA-DIGIFOLK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Portugal,Ireland,Mexico
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 856257.14
EU funding (EUR): 818800.0
Participants: 8
Project status: SIGNED

Music is an element that is present in our daily lives. There are different styles of music, including classical, jazz, pop, rock, etc. There is a kind of music, folk music, which is of great interest due to its peculiar characteristics and the social context it represents or has represented. This music is a form of social and cultural identification that allows us to twin and recognize ourselves as folks, and also to promote cultural diversity through knowledge of other music. This project proposes creating a platform that contains and presents information about folk music from European and Ibero-American culture. The main goal is to create a whole paradigm in which folk music can be understandable from a ethnomusicological, musical and educative point of view. Furthermore, we aim to bring folk music closer to the public creating an interactive and attractive platform that incorporate multimedia information (audio files, scores, visual information about patterns and similarities, etc.). As the platform will be open to the common public, all people that might be interested in folk music can get access, enjoy the resources or even submit their own materials. Our goal is aligned with three main pillars: i) Create a new paradigm to make the musical and ethnomusicological analysis easier for the community; ii) Show knowledge discovery through the application of new technologies in the platform; iii) Bring folk music to educative and public environments. Our project complies with the digitalization pillars proposed in the strategic plan of MSCA, through the inclusion of computer sciences technologies to get a new vision in music analysis. It also helps to create a more resilient, inclusive and democratic European society and includes actions that are also mentioned in the cluster “Culture, Creative and Inclusive Society”, through the inclusion of folk repertoires that reflect cultural issues from different European and Ibero-american regions.

Keywords: oral and traditional music
Growing Up in the Digital Age of Disinformation (DISINFORMED TEENS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Disinformation is a growing and pervasive problem in modern society. Adolescents spend over 6.5 hours per day on their smartphones and many use social media as a primary information source. There is ample indication in the developmental science literature that adolescents might be particularly susceptible to disinformation. Yet surprisingly little is known about how susceptibility to disinformation changes throughout adolescence and how we might foster youth’s resilience against disinformation. Here I propose an innovative research program to develop the first comprehensive account of susceptibility to disinformation during adolescence. With this fundamental knowledge, I will develop new instruments to promote truth discernment in youths, which are urgently needed in today’s digital era. While many prior developmental studies rely on self-reported online activities, the proposed research will innovate this field by gaining deep and objective insights by applying natural language models to adolescents’ social media data, computational models of reinforcement learning and decision-making in novel experimental paradigms, and network analyses to capture the interplay between risk factors. This approach will gain novel and necessary insights into: 1. the types of (dis)information that adolescents encounter on social media. 2. How persuasion techniques affect adolescents' veracity judgements and information sharing decisions. 3. The learning processes that underlie social influence and impact adolescents’ veracity judgements and information sharing decisions. 4. The individual differences which make adolescents more susceptible to disinformation and extreme views. The findings will result in a comprehensive, fundamental understanding of adolescents’ susceptibility to disinformation, including risk factor contexts, and the first evidence-based educational program against disinformation tailored to youths’ age specific needs.

Keywords: adolescence,social media,disinformation,misinformation,psychology,cognitive science,social development,cognitive development,social influence,reinforcement learning,cognitive modelling
sErvitization of Industry X.0 Assets powered by secure, Resilient and immersive digital twin teCHnologies (EXARCH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Sweden,Portugal,Cyprus,Italy,Romania,Spain,Luxembourg
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 2138554.29
EU funding (EUR): 1803600.0
Participants: 9
Project status: SIGNED

Recent EU decisions highlight the need to further invest and innovate in the field of Digital Twin (DT) technologies, targeting at unrestricted monitoring, visualization, simulation and optimization of critical infrastructures, processes, subsystems and industrial processes in a manner that is economically and environmentally sustainable, efficient and flexible. Digital Twins (DTs) constitute the new field of convergence of the biological, physical and digital worlds and form the basis of the twin transition by 2030; yet, their development requires an interdisciplinary view of the main processes that govern the operation of enterprises, to effectively develop and/or embrace new products. Fully-fledged digitization of physical assets in the production field through DTs (i.e., workers, mobile/fixed robots, stock, fleet), constitutes the main vehicle towards the adoption of innovative and emerging business models that distinct the ownership of assets from their daily usage and management, a.k.a. servitization. The EXARCH programme sets the ambitious aim to design, implement and experimentally demonstrate the performance of a fully modularized end-to-end digital twin platform, along with the necessary algorithmic innovations, to support of the emerging Asset-as-a-Service (AaaS) paradigm. The EXARCH DT-enabled platform brings forth the design of cloud-native AaaS microservices that fully leverage the exciting new capabilities offered by 6G mobile data networks as well as state-of-the-art advances in semantics-aware computer vision, aiming to create a resilient and immersive biological, digital and physical Industry X.0 continuum. EXARCH targets to the development of an immersive user-centric service suite designed to automate AaaS management, addressing unique cybersecurity challenges posed by remote monitoring, control and optimization of Industry X.0 assets while making the most out of the opportunities offered by fully-fledged digitalization of cyber physical assets.

Keywords: digital twins asset as a service industry 5 0
Intelligent Degradation Design of Biomedical Rare Earth Magnesium Alloys (DREAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-21
End date: 2027-07-20
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Magnesium (Mg) alloys, with their excellent mechanical properties, outstanding biocompatibility, and gradual degradation within the body, are demonstrating vast potential for applications in the medical field. Their greatest advantage lies in their ability to degrade in sync with the body’s healing process, eliminating the need for a second surgery to remove traditional implants. However, in chloride-rich physiological environments, Mg alloy implants are prone to rapid corrosion, leading to early failure and posing risks to patient health. To address this challenge, the DREAM project integrates cutting-edge research on Mg alloys, convolutional neural networks (CNNs), density functional theory (DFT) calculations, and pH-responsive materials, with the goal of developing intelligent biomedical Mg alloys with controlled degradation rates. First, the project will establish a comprehensive database of Mg-Zn-Ca-RE (rare earth) alloy corrosion and mechanical properties to support the accurate prediction of alloy performance using CNN models. By incorporating DFT calculations, the project will gain deeper insights into the corrosion and mechanical behaviours of Mg alloys, further enhancing the prediction accuracy of the CNN models. Ultimately, the optimized alloys will be combined with pH-responsive materials to achieve intelligent degradation control, ensuring the degradation rate aligns with the body’s healing process. Through this innovation, Mg alloys are expected to see a 30-40% improvement in corrosion resistance, a 50% reduction in experimental time, and a significant decrease in harmful waste production. The DREAM project will play a crucial role in the advancement of green medical technologies while driving innovation in biomedical materials.

Keywords: rare earth magnesium alloys,intelligent degradation control,convolutional neural networks,density functional theory,ph responsive
Advancing Ecosystem-Based Management through Hybrid Blue-Grey Infrastructures in Marine and Coastal Areas (TRANSEATION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Spain,Austria,Italy,Germany,Israel,Denmark,Norway,France
Call: Demonstration of marine and coastal infrastructures as hybrid blue-grey Nature-based Solutions (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 5598293.61
EU funding (EUR): 4999582.79
Participants: 16
Project status: SIGNED

The TRANSEATION main objective is to demonstrate the effectiveness of marine and coastal hybrid blue-grey infrastructures and validate a new level of ecosystem-based management combining nature-based solutions, social implication digitalization to the protection and restoration of marine ecosystem health and services. To ensure the success of this main objective, the TRANSEATION project counts on partners and collaborators with broad expertise in relevant areas covering four types of entities in the project (from research and technological centers to companies and offshore industrial operators) as follows: managerial (CMCC, IOW, GLP, CTN), industrial (SAITEC, ITASKORDA, GEOCORAIL, CCELL), scientifical (OE, UOH, CMCC, AZTI, GAIKER, IOW, DTU, CTN) and participatory (SO, ECOOCEAN, AZTI, CTN, CMCC). In addition, this project implements three user cases towards marine and coastal infrastructures, considering the different life cycle stages. Then, the following 5 specific objectives are identified: Specific objective 1. Apply EBM through a systema approach to integrate hybrid NbS in marine and coastal infrastructures to support the preservation and restoration of marine biodiversity and ecosystem services simultaneously with addressing multiple societal challenges (environmental, social and economic benefits). Specific objective 2. Demonstrate the effectiveness of [3] type of coastal and marine infrastructures as hybrid NbS both to preserve ecosystems and support their restoration considering its replicability and scaled-up. Specific objective 3. To identify limiting factors, gaps and current issues of existing LEED initiative regarding “blue building”, setting up links with previous projects. Specific objective 4. To analyze the benefits and potential trade-off of these hybrid solutions in short and long-term for marine biodiversity and ecosystem services protection and restoration. Specific objective 5. Digital solutions for monitoring, analysis and social involvement
CO2 Mineralisation: Conversion of Waste to New Building Materials (MIN CO2)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The goal of MIN CO2 is to test the innovation and commercialisation potential of an idea for: i) increasing sustainability, ii) decreasing atmospheric CO2 and iii) producing a valuable, low CO2 footprint building material from noncombustible solid waste. Results from our ERC research led to the idea: Can we react waste materials with CO2 and water to produce fine grained material of value for new concrete? Current solutions for CCS are expensive and require extensive infrastructure but if this idea works, the technology will generate income; our estimates suggest ~ 50 €/T from the sale of the end product. In MIN CO2, we shall test the idea and optimise the system parameters at bench scale, then design, build and test a laboratory prototype reactor, where rate of reaction and formation of a minimum viable product can be achieved in a flowthrough process, bringing us from our current TRL 2 to TRL 4. One patent has been submitted; others will follow as appropriate. Our preliminary market analysis and business case, as well as discussions with potential partners (waste suppliers, a local waste-to-energy plant and a concrete company), bode well for writing a proposal for Innovation Funding at the end of the POC grant. Larger company stakeholders promise investment when we are able to demonstrate viability in a factory pilot (TRL 6). Our long term goal is a startup, that sells CO2 Traps and knowhow for installation into existing factory chimneys, for European and eventually global markets. Initial discussions with members of the public and the media range from positive to enthusiastic because most of society’s fears about CCS are avoided with our approach. As our prospective partner from the concrete industry summarised, “If this works, it will be big”. Our small, dedicated team is convinced that it will.