Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting TGF-β activation, likely the core mechanism of immunosuppression by human regulatory T cells. (TARG-SUP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-04-01
End date: 2021-03-31
Duration (months): 60.0
Total project cost (EUR): 1993125.0
EU funding (EUR): 1993125.0
Participants: 1
Project status: CLOSED

Regulatory T lymphocytes (Tregs) inhibit immune responses and are required to maintain immune tolerance. Tregs express membrane protein GARP, which displays latent TGF-β1 on the cell surface. Immunosuppression by human Tregs appears to require GARP-mediated activation of TGF-β1. My objectives are to unravel the molecular aspects of TGF-β1 activation by GARP and determine the functional importance of this process in physiological and pathological conditions where Tregs or other GARP-expressing cells are present. As this implies the development of new tools to modulate GARP-dependent TGF-β1 activation and Treg immunosuppression, we will also explore their potential for the treatment of immune-related human diseases, and notably cancer. More specifically, I will: - Derive antibodies that modulate GARP-mediated TGF-β1 production by human Tregs and perform structural analyses in the presence of these antibodies to identify tri-dimensional changes in GARP/TGF-β1 complexes that lead to the release of active TGF-β1. - Identify and characterize additional proteins implicated in TGF-β1 activation by human Tregs, as GARP is required but not sufficient for TGF-β1 activation by Tregs. - Determine the immunological and clinical impact of inhibitory anti-GARP mAbs on cancer in mice. We will derive anti-murine GARP mAbs. As an alternative, we will generate mutant mice expressing a chimeric mouse/human GARP that is recognized by anti-human GARP mAbs. The antibodies will be tested in tumour-bearing mice treated or not with other immunotherapies including vaccines or immunostimulatory antibodies. - Determine whether blocking anti-GARP mAbs improve immune responses to microbial vaccines or to chronic infections, as these represent important applications for transient inhibition of Treg activity in humans. - Analyse the expression and roles of GARP in non-Treg cells to better understand GARP functions, which remain largely unknown, and predict potential toxicities of anti-GARP mAbs.

Keywords: regulatory t cells,tgfbeta,anti tumor immunity
New Ultrasonic Cost-Effective Equipment as Anti-Fouling System for Vessels (BIOECOMARINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

BIOECOMARINE project is born to bring a cost-effective and eco-friendly Anti-Fouling (AF) solution that can be easily adapted to any type of vessel regardless its length or hull material. In this context, BIOECOMARINE focused on the commercial development and further commercialization of a prototype based on the ultrasonic technology that provides vessels full AF prevention while ships are at berth. Since any kind of vessels can benefit from this system, the commercial scope of this system ranges from recreational boats to the maritime transport sector including shipping companies, commercial ports and shipyards. Shipping industry has a high cost due to its high consumption of fuel, which is increased by the biofouling. Avoiding the additional fuel consumption that comes from biofouling means a reduction in the economic cost and CO2 emissions. Moreover, traditional AF coating treatments are not permanent and contain biocidal and other harmful agents with its corresponding environmental impact in water. In this context, BIOECOMARINE will drastically increase AF Coating (AFC) efficiency and durability, reducing AFC treatments up to a third of current practice. Hereby fuel consumption as energy source will be optimized, resulting in a reduction of 5-7% of the annual fuel consumption. Finally, using BIOECOMARINE, the estimated saving based on total boat operation expenses are between the range of 15 – 20%. To sum up, BIOECOMARINE is an innovative and sustainable product that has technical (easy installation, programmable, full protection, no effect in ship machinery…), economic (no docking period, reduce fuel consumption, cheap) and environmental (reduce CO2 consumption, non-toxic) competitive advantages that will lead this product to be the first industrial solution able to offer a low cost, broadly effective, programmable, and truly non-toxic and eco-friendly Anti-Fouling solution.

Keywords: biofouling,anti fouling,coating,ultrasounds,maritime transport,commercial vessel,recreational vessel,fuel consumption,co2 reduction
ULTRA-EFFICIENT WIRELESS POWERED MICRO-ROBOTIC JOINT FOR HEALTH APPLICATIONS (UWIPOM2)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Spain,Poland,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2019-10-01
End date: 2023-06-30
Duration (months): 45.0
Total project cost (EUR): 2987118.75
EU funding (EUR): 2987118.75
Participants: 5
Project status: SIGNED

This project seeks to develop the first micrometric-size Ultra-Efficient Wireless POwered Micro-robotic joint (UWIPOM2), enabling the creation of micro-robotic complex mechanisms for minimally invasive micro-surgery techniques and in-vivo health treatments. The foreseen robotic joint will contain a micro-motor connected to a new type of long-lasting gearbox which reduces drastically friction and simplifies assembly. Moreover, the robotic joint (motor + gear) will be wireless powered through gigahertz electromagnetic waves, thus providing infinite autonomy to any tool or micro-robot activated by UWIPOM2. The scientific-technological aim is to create the first building block able to power future healthcare micro-robots. Test in in-vivo like environment will be done to demonstrate its feasibility. If the risky scientific and technological challenges hereby proposed are overcome, radically new outstanding minimally invasive micro-surgery techniques and new non-invasive inside body treatments will be enabled, saving thousands of lives.

Keywords: mems
European Scalable Complementary Offshore Renewable Energy Sources (EU-SCORES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Innovation actions
Countries involved: Germany,Ireland,Italy,Italy,Ireland,Monaco,Finland,Sweden,Switzerland,Belgium,Sweden,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,Portugal,Portugal,Portugal
Call: Innovative land-based and offshore renewable energy technologies and their integration into the energy system (H2020-LC-GD-2020-1, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 45776319.72
EU funding (EUR): 34831483.81
Participants: 25
Project status: SIGNED

Efficient and effective use of offshore renewables is pivotal in the transition of the EU to become a net-zero economy in greenhouse gas emissions by 2050. EU-SCORES will unlock the large-scale potential of the roll-out of offshore renewable energy in multi-source parks across different European sea basins through two highly comprehensive and impactful demonstrations: (1) An offshore solar PV system in Belgium co-located with a bottom fixed windfarm and; (2) A wave energy array in Portugal co-located with a floating wind farm. The multi-source demonstrations in EU-SCORES will showcase the benefits of a continuous power output harnessing the complementarity between wind, sun and waves as it leads to a more resilient and stable power system, higher capacity factors and a lower total cost per MWh. These aspects will also improve the business case for the production of green hydrogen within these parks. The full-scale demonstrations will prove how the increased power output and capacity installed per km2 will reduce the amount of marine space needed, thereby leaving more space for aquaculture, fisheries, shipping routes and environmentally protected zones. Additional benefits attained by co-using critical electrical infrastructures and exploring advanced operation and maintenance methodologies supported by innovative autonomous systems will further lower the costs per MWh. The involvement of major project developers and utility companies (EDP, EGP, SBE, RWE, EnBW, Eneco, OceanWinds, and Parkwind) will ensure an accelerated path towards commercialisation of these innovative parks. Altogether, through a highly competent, skilled and motivated consortium EU-SCORES will pave the way for bankable multi-source parks including wind, wave and floating solar systems across different European sea basins by 2025, thereby supporting the stability and resilience of the European energy system, while considering sustainability, local stakeholders and existing ecosystems.
Developing and implementing a community-based intervention to create a more supportive social and physical environment for lifestyle changes to prevent diabetes in vulnerable families across Europe (Feel4Diabetes)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Belgium,Belgium,Bulgaria,Greece,Hungary,Finland,Finland,Greece
Call: Global Alliance for Chronic Diseases: prevention and treatment of type 2 diabetes (H2020-HCO-2014, 2014)
Start date: 2014-12-01
End date: 2019-08-31
Duration (months): 57.0
Total project cost (EUR): 2997405.0
EU funding (EUR): 2997405.0
Participants: 10
Project status: CLOSED

The Feel4Diabetes project addresses “HCO5-2014: Global Alliance for Chronic Diseases: prevention and treatment of type 2 diabetes”. The aim of this project is to develop, implement and evaluate a community-based intervention aiming to create a more supportive social and physical environment to promote lifestyle and behaviour change to prevent type 2 diabetes among families from low and middle income countries and from vulnerable groups in high income countries in Europe. Methods: The PRECEDE-PROCEED Model will provide the theoretical framework for the development, implementation and evaluation of the Feel4Diabetes intervention. The framework has two phases, namely the PRECEDE and PROCEED phase. During the PRECEDE phase, the target population as well as behaviours related to type 2 diabetes and their determinants will be identified. Existing research programs and guidelines for type 2 diabetes prevention, policies, legislation, local infrastructure and human resources will also be recorded. Based on the knowledge gained from this phase, a low-cost and applicable in low-resource settings community-based intervention programme will be developed, with the active engagement of local stakeholders, providing access to the existing infrastructure and human resources wherever feasible. During the PROCEED phase, the intervention will be implemented and its process, impact, outcome, cost-effectiveness and scalability will be evaluated. The results of the intervention will be disseminated, aiming to embed it into policy and practice. Consortium: The Feel4Diabetes multidisciplinary consortium incorporates the necessary expertise on diabetes prevention, behaviours, nutrition, physical activity, policy and health economics. It consists of 10 partners from 7 universities, 1 research institute, 1 advocacy group and a small-medium enterprise, representing European low-middle income, high income and under socioeconomic crisis countries.

Keywords: type 2 diabetes prevention,vulnerable populations,families,community based lifestyle intervention,school,policy makers,physical activity,inactivity,eating habits,determinants
A New Waveform for Joint Radar and Communications Beyond 5G (OTFS-RADCOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-10-14
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

Wireless communication systems are using increasingly larger carrier frequencies, from 900 MHz for 2G cellular, over 2 GHz for 3G, 2.5 GHz for 4G/LTE, and leaping to 28 GHz in 5G. Similar trends are visible for WiFi-based communication, with the 802.11ad standard operating at 60 GHz. This places wireless communication services very close to short range radar frequency bands. Such radars operate at frequencies around 24 GHz, 63 GHz, as well as at 76-81 GHz, and include both automotive radars and indoor personal radars. In next-generation networks, a large number of spectrally coexistent radars and communication devices can thus bring up the problem of mutual interference, which threatens radar safety and communication throughput. The objective of this action is to provide a new and industrially relevant solution to the problem of interference in spectrally congested wireless environments. To this aim, we propose a novel co-design of radar and communications (RadCom) systems via a joint Orthogonal Time-Frequency-Space (OTFS) waveform, which enables both functionalities to be implemented on a single hardware. By multiplexing symbols in the delay-Doppler domain, the OTFS can overcome major limitations of the Orthogonal Frequency Division Multiplexing (OFDM) waveform (the de-facto standard for downlink communications), such as high peak-to-average-power ratio (PAPR), small channel coherence time and inter-carrier interference. The OTFS has recently been proposed for communication and we believe it holds great potential for radar as well. In close collaboration with local industry (Volvo, Ericsson), we propose to (i) derive and experimentally validate OTFS received signal models, (ii) design OTFS radar signal processing chain, and (iii) design an integrated OTFS RadCom solution. If successful, the project results can be employed in a wide range of applications (e.g., high-speed automated vehicles, dual-functional radar base stations) and contribute to beyond 5G standards.

Keywords: joint radar communications,spectral co existence,next generation wireless networks,orthogonal time frequency space,orthogonal frequency division multiplexing
Strategies for health protection, pollution Control and Elimination of Next generAtion RefractIve Organic chemicals from the Soil, vadose zone and water (SCENARIOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Israel,Germany,Italy,Spain,Spain,Italy,Italy,Cyprus,Finland,Greece,Sweden,Greece,United Kingdom,Luxembourg,Denmark
Call: Innovative, systemic zero-pollution solutions to protect health, environment and natural resources from persistent and mobile chemicals (H2020-LC-GD-2020-3, 2020)
Start date: 2021-11-01
End date: 2025-10-31
Duration (months): 48.0
Total project cost (EUR): 11985716.25
EU funding (EUR): 11985716.25
Participants: 19
Project status: SIGNED

SCENARIOS will devise and demonstrate a comprehensive set of technological solutions to address the detection, (bio)monitoring, long-term toxicity, risk assessment, pollution control and remediation of Per- and polyFluoroAlkyl Substances (PFASs) as a test bed for zero pollution ambition from refractory and mobile organic chemicals. SCENARIOS's approach and technologies will be self-sustainable, (near) net-zero energy and will smoothly integrate in the circular economies of EU countries and worldwide. A harmonised composition of the project consortium encompassing renewed academic and research centers and competitive technological SMEs will ensure SCENARIOS? replication and impact and continental level and beyond. The project will fill the knowledge gap and deliver disruptive remediation TRL advancements for probably the most awkward and widespread toxic class of contaminants -PFAS- with unprecedented energetic balance and the near absence of external chemical additions promoting EU leadership in the sector and a significant advance in the research field. The industrial core of SCENARIOS will enable four demonstrations (case studies) within EU industries and a public health institution stepping forward a set of industrial and societal sectors where pollutant remediation and health surveillance have excellent potential for the Green Deal implementation.

Keywords: air bubbles,integrated approaches to testing and assessment iata,hazard assessment,new approach methodologies nam,omics,per and poly fluoroalkyl substances pfas,separation,sensors
Scooping Device for Aerial Forest Fire Suppressant (SCODEV)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Germany,Belgium,Belgium,Netherlands
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2016-02-01
End date: 2019-11-30
Duration (months): 46.0
Total project cost (EUR): 3856000.0
EU funding (EUR): 2699200.0
Participants: 4
Project status: CLOSED

The topic of this proposal is to determine the final production model of a scooping-device that allows non-amphibious conventional airtankers to scoop water from a body of water (sea, lake, river or a dam-reservoir) flying at an altitude of +/- 15 metres, in order to suppress forest fires much more quicker by 5 times. Today only dedicated amphibious airtankers, like the so-called Canadairs CL 415, can scoop water. Non-amphibious conventional airtankers have to return to the airport to refill with loss of time. Today such a scooping device (Scodev) does not exist and it will be a revolution in forestfire combating industry, thus it is disruptive. Feasibility studies have shown that it is possible to scoop large amounts of water in very brief time of 15 seconds. Prototype flying tests will prove this ability and serve as mandatory application procedure for EASA airworthiness certification. Once the prototype tests are finished, the Scodev is ready for the market. With the patented Scodev, operators of airtankers will improve their dropping-capacity from 1 to 5 droppings per hour. By improving the dropping capacity with 5 times, the suppression-efficiency will improve exponentially up to 8 times, which means that the damage will be reduced between 50 and 80 %. Today worldwide there are only 110 amphibious Canadairs. There are 1200 non-amphibious airtankers, owned by civil protection entities or forest service bodies. In addition there are 1500 large military aircrafts for disaster relief, and 1500 small airtankers SEAT. Meaning the potential is very big and the trend is increasing due to global warming. Due to forest fires millions of hectares are lost and the financial damage is hundreds of billions of Euros. The use of the Scodev will decrease not only financial losses, but the environmental and ecological damages will also be radically reduced.

Keywords: non amphibious,forestfire,airtanker
Industrialisation of Jet Noise Prediction Methods (INSPiRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany
Call: Jet Noise Reduction Using Predictive Methods (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-07-01
End date: 2019-09-30
Duration (months): 39.0
Total project cost (EUR): 398000.0
EU funding (EUR): 398000.0
Participants: 1
Project status: CLOSED

The project, entitled "Industrialisation of Jet Noise Prediction Methods" (INSPiRE), addresses fully the scope outlined in Topic JTI-CS2-2015-CFP02-ENG-03-02 "Jet Noise Reduction Using Predictive Methods". Turbulence-resolving CFD coupled to efficient far-field integration methods is established as an accurate means for the prediction of isolated jet noise. The trend towards increasing fan diameters however leads to the growing importance of installation effects, such as jet-flap interaction noise. The simulation of such effects however requires numerous developments in the underlying numerical approaches to achieve increased computational efficiency, flexibility and reduced user burden. Such improvements will be developed, implemented and validated for complex installed jet flows (including configurations with noise-reducing design features) within the INSPiRE project. Together with comprehensive best practice guidelines, the developments will make a significant contribution to improving confidence in simulation methods and to achieving industrial exploitation of turbulence-resolving approaches. This is furthermore ensured by the implementation and validation of methods directly in the HYDRA software. High cost-efficiency and low technical risk of the INSPiRE project is facilitated by the input of advanced methods and best practice developed within the framework of previous and ongoing projects, both European and nationally-funded. A strong and positive impact is foreseen, both towards the challenging noise reduction goals set in the renewed ACARE SRIA, as well as towards the Horizon 2020 pillar of building industrial leadership in Europe. Clear perspectives for the exploitation of INSPiRE results, both by the European aero engine OEM sector and by the SME coordinator, are identified.

Keywords: jet installation noise,grey area mitigation,hybrid structured,unstructured meshing,far field sound integration,statistical error,initial transient