Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovation by Law Enforcement Agencies networking (ILEAnet)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Coordination and support actions
Countries involved: Germany,Germany,Ireland,Austria,Spain,Estonia,Italy,Israel,Cyprus,Poland,Poland,Bulgaria,Hungary,Romania,Slovakia,Slovakia,Latvia,France,France,Czechia,United Kingdom
Call: Pan European Networks of practitioners and other actors in the field of security (H2020-SEC-2016-2017-1, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 3482146.25
EU funding (EUR): 3482146.25
Participants: 23
Project status: CLOSED

The ILEAnet project will set up and develop a sustainable network of Law Enforcement Agency (LEA) practitioner organisations from all over Europe. The mission of this network will be to stimulate LEA capabilities to influence, develop and take up research, development and innovation (RDI) that is useful and usable for LEAs, and thereby help them to tackle the major challenges they face. The network will be organised around ILEAnet National Contacts (INCs) who will be in charge of federating the respective networks of practitioners, policy makers, academics, industrial players and other RDI stakeholders in their respective countries. ILEAnet will also operate as a community of people with a common interest in exchanging and collaborating with respect to LEA challenges and needs and LEA-centred RDI. Whilst the organisational ILEAnet Network will be focused – “top-down” - on specific challenges, the ILEAnet Community of people will contribute “bottom-up” ideas to produce innovative approaches to face newly arising challenges. An online community platform will enable professional social networking and mutual online assistance related to new solutions and best practice to address LEA challenges. The platform will support online and physical meetings and discussions, and will provide the infrastructure for efficient knowledge management. Synthesising top-down approaches and bottom-up ideas in iterative survey-organise-brainstorm-analyse-propose-discuss-poll processes, ILEAnet will build up a broad portfolio of RDI results and new RDI project concepts, and will deliver recommendations for future RDI policies. ILEAnet will hence catalyse innovation between LEAs and between LEAs, academics and industry. This will enable LEAs not only to take up mature results but also to prepare and influence future RDI efforts which could be taken up by individual or groupings of organisations and countries as well as by European research funding programmes.

Keywords: law enforcement agency,civil protection,community platform
Directed Protein Evolution for Synthetic Biology and Biocatalysis (ES-Cat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Israel,Germany,Belgium,Czechia,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-03-01
End date: 2021-11-30
Duration (months): 57.0
Total project cost (EUR): 3827031.48
EU funding (EUR): 3827031.48
Participants: 19
Project status: CLOSED

ES-Cat will use directed evolution as a tool to reproduce Nature's remarkable ability to generate molecular machines - in particular enzymes – that perform at levels near perfection. Instead of seeing rational and combinatorial approaches as alternatives, we combine them in this network to achieve a ‘smarter’ and more efficient exploration of protein sequence space. By harnessing the forces of Darwinian evolution and design in the laboratory we want to (i) screen large and diverse libraries for proteins with improved and useful functions, (ii) optimize existing proteins for applications in medicine or biotechnology and (iii) provide a better understanding of how existing enzymes evolved and how enzyme mechanisms can be manipulated. This Network brings together leading academic and industrial groups with diverse and complementary skills. The range of methodologies represented in ES-Cat allows an integrated approach combining in silico structural and sequence analysis with experimental high-throughput screening selection methods (phage-, ribozyme and SNAP display, robotic liquid handling, lab-on-a-chip/microfluidics) with subsequent systematic kinetic and biophysical analysis. This integration of methods and disciplines will improve the likelihood of success of directed evolution campaigns, shorten biocatalyst development times, and make protein engineering applicable to a wider range of industrial targets. It will also train the next generation of creative researchers ready to fill roles in tailoring enzymes and other proteins for industrial application in synthetic biology efforts to move towards a bio-based economy, rivaling advances that are being made in the US and allowing the EU economy to harvest its evident socio-economic benefits.

Keywords: directed evolution,protein engineering,droplet microfluidics,computational protein design,phage display,high throughput computation for enzyme redesign,catalytic promiscuity,enzyme mechanism
Targeting the adaptive capacity of prostate cancer through the manipulation of transcriptional and metabolic traits (CancerADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-11-01
End date: 2025-10-31
Duration (months): 72.0
Total project cost (EUR): 1999882.0
EU funding (EUR): 1999882.0
Participants: 1
Project status: SIGNED

The composition and molecular features of tumours vary during the course of the disease, and the selection pressure imposed by the environment is a central component in this process. Evolutionary principles have been exploited to explain the genomic aberrations in cancer. However, the phenotypic changes underlying disease progression remain poorly understood. In the past years, I have contributed to identify and characterise the therapeutic implications underlying metabolic alterations that are intrinsic to primary tumours or metastasis. In CancerADAPT I postulate that cancer cells rely on adaptive transcriptional & metabolic mechanisms [converging on a Metabolic Phenotype] in order to rapidly succeed in their establishment in new microenvironments along disease progression. I aim to predict the molecular cues that govern the adaptive properties in prostate cancer (PCa), one of the most commonly diagnosed cancers in men and an important source of cancer-related deaths. I will exploit single cell RNASeq, spatial transcriptomics and multiregional OMICs in order to identify the transcriptional and metabolic diversity within tumours and along disease progression. I will complement experimental strategies with computational analyses that identify and classify the predicted adaptation strategies of PCa cells in response to variations in the tumour microenvironment. Metabolic phenotypes postulated to sustain PCa adaptability will be functionally and mechanistically deconstructed. We will identify therapeutic strategies emanating from these results through in silico methodologies and small molecule high-throughput screening, and evaluate their potential to hamper the adaptability of tumour cells in vitro and in vivo, in two specific aspects: metastasis and therapy response. CancerADAPT will generate fundamental understanding on how cancer cells adapt in our organism, in turn leading to therapeutic strategies that increase the efficacy of current treatments.

Keywords: cancer cell adaptability,therapeutic vulnerabilities,molecular basis for cancer progression,prostate cancer,transcriptional and metabolic programs in tumours
WIRE2017 (WIRE2017)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Slovakia
Call: WIRE VIII Conference (H2020-IBA-SEWP-WIRE-8-2017, 2017)
Start date: 2017-03-01
End date: 2018-02-28
Duration (months): 12.0
Total project cost (EUR): 247537.5
EU funding (EUR): 247537.5
Participants: 1
Project status: CLOSED

The purpose of this proposal is the organisation of the Week of Innovative Regions in Europe 2017 (WIRE VIII) conference in Kosice (Slovakia). The conference will be held from 28 to 30 June after the Slovak Presidency of the Council of the European Union. The general objectives of WIRE VIII are as follows: • Contributing substantially to maximising and understanding the societal impact of research, innovation and regional policy in digitalisation on regions and people • To support R&I ecosystem stakeholders (quadruple helix) in utilization of benefits from digitalisation and enhance trusted initiatives and policy formation for effective innovative and socially responsible regional development • To contribute to responsible creation of the future in H2020 and regional R&I

Keywords: societal and economic impact,digital research and innovation,creative industry,science and art,european rural areas,social innovation
Enhanced Mass Transport in Electrochemical Systems for Renewable Fuels and Clean Water (EnTER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

To meet the growing demand for green energy carriers and clean water for the next decades, we can use the increasing supply of harvested solar and wind energy to synthesize fuels (hydrogen, syngas, ammonia, etc.) and clean water via electrochemical methods. Electrochemical methods have the advantage of single-step, energy-efficient and low-temperature conversion of chemicals. However, despite developments in electrocatalysts and system design in the past decade, none of the electrochemical methods has grown to a market-leading technology in the energy or water sector because of limitations in process intensification. A boost in electrical current density, without sacrificing energy efficiency, is required to allow large-scale deployment. This process intensification needs breaking three limitations in mass transport, at three different scales: 1) the diffusion boundary layer (microscale), 2) gas bubble interference (mm-scale) and 3) concentration gradients in the flow compartments bulk. This ERC project will use a multiscale approach to address these three mass transport limitations, and has the objective to understand and enhance mass transport using novel concepts. Diffusion limitations will be addressed via studying suspension electrodes, gas bubbles will be controlled while synergistically disturbing the diffusion boundary layer via pressure swing control, and reactor engineering concepts that are new to the field of electrochemistry are used to mitigate macro-scale concentration gradients. Water electrolysis, CO2 electrolysis and electrodialysis will be used as tool to evaluate these strategies, using fluorescence lifetime imaging (FLIM) and micro particle image velocimetry (μPIV) to observe the local environment at microscale within large-scale systems. This multiscale approach with in-situ measurements of local flow and concentrations will target the fundamental understanding and control of mass transport limitations for universal electrochemical conversion.
Protein Adsorption onTo CHarged surfacES (PATCHES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-16
End date: 2020-05-15
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Biocompatibility of medical implants and devices is of paramount importance for their safety, effectiveness, and utility. The release of medical devices that are not biocompatible and biodurable is still an issue (for instance, more than 100.000 European patients are implanted with Metal-on-Metal hip joints which have been found toxic under specific circumstances), which has recently resulted in a proposal of the European Commission for the amendment of the Medical Device Directive. Biocompatible materials should be assessed based on their chemical, physical and toxicological properties as well as on their interaction with body fluids. A rapid adsorption of proteins on the foreign material will favour the anchorage of the cells, leading to safer and more durable medical implants/devices. Proteins adsorption is influenced by chemical and molecular structure characteristics and by the distribution of electric charges at the interface between surface and proteins. The distribution of surface charge has been so far attributed to the chemical reactions of the surfaces with body fluids. However, other aspects such as contact conditions and relative motions of surfaces have been recently appointed as crucial factors in the distribution of charge on the surface and thus on protein adsorptions. The proposed project will focus on the analysis of tribologically induced surface charge distribution on different biocompatible materials and on its impact on protein adsorption. This research will be conducted using Density Functional Theory (DFT) calculations and classical Molecular Dynamics (MD) simulation methods and the models will be validated by experimental tests. The project’s main goal is the design of a multi-scale hybrid computation/experimental methodology that will allow to assess biocompatibility and pave the way to the future creation of novel biocompatible materials for both implant and nanomedical devices.

Keywords: tribocharging,biomaterials,molecular dynamics simulations,surface charge analysis
Deploying the novel, large-scale Ateknea Air City Monitoring Platform (A2CM)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-04-01
End date: 2017-08-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We want to commercialise a very powerful, innovative and unique urban air monitoring system that will permit, for the first time, to really map air pollution in cities on a scale previously unimaginable. Air pollution is a major problem for public health, and it is only expected to get worse due to urbanization on a global scale. Air pollution in cities is linked to up to 1 million premature deaths and 1 million pre-native deaths each year. Urban air pollution is estimated to cost approximately 2% of Gross Domestic Product (GDP) in developed countries and 5% in developing countries. The Ateknea Air City Monitoring Platform (A2CM) is based on a large deployment of novel low-cost, reliable and portable air quality sensors using an advanced post-processing algorithm that permits achieving valuable and accurate air measurements from low-cost gas sensors. The installation of A2CM nodes placed in streetlights in a dense matrix will permit having a high spatial and temporal resolution required to define a solid plan for air quality enhancement. The overall goal of the proposed project is to bring to market this dense and fast pollution mapping tool for cities. We have completed the development of the mobile version of the sensor node technology that is already being commercialised and used by several customers, but we need the SME Instrument funding scheme to finalize the technology evolving from the mobile version to an standalone version, to pivot the business model from a Software as a Service (SaaS) to a Platform as a Service (PaaS), and to undertake two intensive pilot tests of the technology in two different cities. In Phase 1, our specific objective is to prepare a clear Feasibility Study and Business Plan on how to reach and properly exploit this extraordinary technology. The project clearly tackles the EU challenges related to air pollution and climate change mitigation, and will undoubtedly help reaching the air pollution levels defined by the EC.

Keywords: urban air pollution,gas sensors,electrochemical sensors,particulate matter sensor,smart cities,internet of things,platform as a service,pollution mitigation,pollution mapping tool
PVC-O Fittings based on MOLECOR’s Molecular Orientation TOM® technology (FITTOM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 1424048.75
EU funding (EUR): 996834.13
Participants: 1
Project status: CLOSED

The main objective of FITTOM is the development of a new technological industrial process able to produce innovative fittings commercially competitive for water transport. Fittings are indispensable in pipe systems to connect straight pipes, fit them to different sizes or shapes and for other purposes such as regulating fluid flow. Currently, most piping systems for high pressure water transport use ductile iron fittings or injection-based plastic-fittings. The former ones are heavy and oxidises relatively easily; the latter require very expensive moulds and large amounts of raw material. MOLECOR has developed a revolutionary technology that provides reliable and user friendly systems that widen possibilities for the global pipe business. This technology demonstrated to be the highest performance, the most eco-friendly and cost-effective solution among the alternatives. The Global water market is an attractive high-volume market, which is currently estimated at about $591 billion and it is expected to reach $1 trillion by 2025. After evaluating the market trends and existing demand, we validated that FITTOM will be a promising business opportunity for MOLECOR. MOLECOR is a pioneer company specialized in the development of the latest technology applying molecular orientation to PVC pipeline solutions. MOLECOR’s proven expertise in the pipes business together with the ambition of the Boards of Directors and its outstanding staff, makes FITTOM’s success a reachable goal. Starting from an existing TRL6 prototype, and after analysing the Feasibility of the project, the current Phase 2 Project will skilfully combine technology advances with marketing and pre-sales activities to ensure a seamless transition from technology implementation to business operation. FITTOM is an excellent chance for MOLECOR to grow and expand in addition to revolutionizing the pipeline sector offering the best mechanical performance and best cost-effectiveness over the current solutions.

Keywords: environment,industrialization,pvc o,fittings
A novel material for watch crystals and watch cases: Mg-spinel transparent ceramics (Mag-Spin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Türkiye
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Watch companies over the last century have continuously experimented with watch materials: from precious metals to simple plastics, watches can be made out of almost anything. Consumers’ expectation from a watch is now not only just for timekeeping but also for their craftsmanship, appeal and design. Therefore, a fresh scratch on an otherwise flawless crystal is a devastating sight for such a watch user. The feeling can be even worse on a brand-new watch, or one that just returned from servicing. The growing preferences of mid & high-range branded watches are therefore contributing significantly to the timepiece demand almost all around the world and Europe is still leading the market as the heart of the watch industry. Thus, vendors have to keep up with the trends by introducing innovative products/parts to satisfy the various needs of the customers. Watch crystals and watch cases are unquestionably important parts since they protect the sensitive working mechanism from the external effects. We are now proposing a novel yet promising approach so as to use transparent ceramics (TCs) as scratch resistant watch crystal and case. Our technology is unique in a way that this hi-tech TC material (Mg-spinel ) is applied to watch crystal & case market. Mag-Spin has built-in advantages over the transparent materials such as acrylic (plexiglass), mineral glass and sapphire used for watches. Mag-Spin is highly durable in extreme conditions and hardly possible to be scratched in everyday use. Our ability to introduce embedded design and colour and to customize the level of transparency also make it suitable material to be used in elegant and fashionable timepiece products. On top of it, unlike sapphire, Mag-Spin’s microstructure allows future improvements from the scientific & engineering perspectives; there is still plenty of space for much better performance. Our progressive material engineered, designed and built is currently at TRL6 stage.

Keywords: mag spin,transparent ceramic,watch crystal,watch case,scratch resistance