Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Phosphorus REcovery for FertiLisers frOm dairy processing Waste (REFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Ireland,Ireland,Italy,Ireland,Italy,Spain,Ireland,Belgium,Belgium,Poland,Sweden,Belgium,Poland,Belgium,France,France,France,Netherlands,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 3463507.86
EU funding (EUR): 3460650.29
Participants: 25
Project status: SIGNED

REFLOW is an interdisciplinary cross-sectoral European Training Network combining world-leading scientists and key stake-holders in dairy processing, fertilizer production and phosphorous recycling with early stage researchers to address important technical and socio-economic challenges associated with the recovery of phosphorous from dairy processing waste water and its recycling into fertilizer products enabling sustainable expansion of the dairy industry in Europe. REFLOW research will (i) mitigate the environmental impact of dairy processing waste on soil and water, (ii) provide safe environmentally sustainable, cost effective closed loop solutions for crop nutrient management (iii) meet the demand for skilled professionals to support the technical, regulatory and commercial development of the market for recycled phosphorous fertilizer products in accordance with the deliverables of the Circular Economy Package. REFLOW will achieve these goals by creating an innovative and entrepreneurial training environment for the next generation of scientists. 13 ESRs will be recruited in a network of 10 beneficiaries and 14 partner organisations who bring complementary expertise and experience of delivering technical solutions, socio-economic modeling, environmental analysis, policy frameworks, high level training and commercial entrepreneurship. Graduating fellows will be equipped with a unique range of relevant interdisciplinary and cross-sectoral skills for careers as independent industrial or academic researchers, entrepreneurs, regulators or agri-environmental specialists. REFLOW will train the Fellows through an integrated and cohesive curriculum of network-wide partner training activities including industrial secondments and embedded commercially driven research projects. The outputs from REFLOW will influence land management practice, the rural bio-economy framework and EU policy goals while significantly progressing the state-of-the-art in Phosphorous recycling.

Keywords: dairy processing waste,phosphorous recovery and reuse,biocircular economy,new fertilisers,soil quality and crop yield,end of waste regulations
Directed Evolution of Photoredox Powered Artificial Metalloenzymes for Stereodivergent Catalysis (PhotoArM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Artificial metalloenzymes have recently emerged as powerful tools to address the ever-growing requirements of chemistry to become more efficient and sustainable. This methodology involves anchoring a reactive transition metal catalyst within a protein to exploit the secondary coordination sphere created around the new active site, which can induce selectivity in reactions and improve turnover numbers. Concomitantly, photoredox and metallophotoredox catalysis, where a small quantity of a light sensitive compound allows non-traditional reactivity though open shell reactive intermediates, has also developed dramatically in recent years. The impressive reaction repertoire is especially synthetically attractive due to the mild conditions required and the ability to activate abundant and generally more inert functional groups. However, the current drawback to this methodology is the high levels of control needed to give the reactions their full synthetic potential. This is where the two fields display complementarity with an unexplored interface: Photoredox Artificial Metalloenzymes. By anchoring a nickel catalyst inside an enzyme pocket with a nearby photocatalyst, it should be possible to control catalytic reactivity by mutagenesis of residues in the secondary coordination sphere. In the proposed case of an sp3-sp3 cross-coupling reaction between a racemic amino acid derivative and bromoalkane, this could potentially allow control over both new stereocentres independently to achieve stereodivergent catalysis. It is subsequently proposed that this methodology could be adapted to include intramolecular cross-coupling reactions, which would beneficially allow access to the valuable monocyclic β-lactam scaffold from suitably functionalised linear substrates. If possible, this may allow efficient access to diastereoisomers potentially difficult to access by other means, which may hold unexplored pharmaceutical potential.

Keywords: artificial metalloenzymes,directed evolution,stereodivergent catalysis,biocatalysis,nickel,high throughput screening
Language switching and script mixing: multilingual landscapes of medieval Scandinavia (LangMix)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2023-02-10
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: CLOSED

The present project aims to investigate the encounter between the Latin and the native vernacular written culture in medieval Scandinavia, through phenomena of language and script switching in epigraphic sources. The spread of Latin is a pivotal point in the development of all European literate societies. Scandinavia represents a unique case study where Latin and the Roman script encountered and mixed itself with an 800 year old native tradition based on the local vernacular and the runic script. From being monolingual and monoscriptal, Scandinavia became multilingual and multiscriptal. Through an interdisciplinary framework to be developed in synergy with leading scholars at the University of Oslo, epigraphic methods completed by multimodal and sociolinguistic analyses within a linguistic landscape perspective will serve to determine: 1) the medieval writers’ multilingual and multiscriptal proficiency; 2) the status relationship between the Latin and runic written tradition; and 3) the ideological presuppositions and purposes of the use of different languages and scripts. For the first time, these phenomena will be studied systematically and through an unexplored combination of historical material and modern sociolinguistic methods. This will not only yield new insights in the multilingual literacy of medieval Scandinavia and on its underlying cultural and ideological aspects, but also in its significance in a European context. By embedding the Scandinavian case in the process of cultural and political formation of Europe, this project will also contribute to understand the common cultural heritage in modern European societies.

Keywords: epigraphy,philology,multilingualism,linguistic landscapes,multimodality,runology
Integrated Modular Energy Systems and Local Flexibility Trading for Neural Energy Islands (MERLON)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Austria,Spain,Spain,Spain,India,Cyprus,Greece,Belgium,Greece,Greece,France,United Kingdom,United Kingdom
Call: Integrated local energy systems (Energy islands) (H2020-LC-SC3-2018-ES-SCC, 2018)
Start date: 2019-01-01
End date: 2022-04-30
Duration (months): 40.0
Total project cost (EUR): 7311738.19
EU funding (EUR): 5739471.25
Participants: 19
Project status: CLOSED

The de-centralization of electricity generation requires equally de-centralized and affordable solutions to integrate more RES, increase the security of supply and decarbonize the EU energy future. The combination and unique integration of de-centralized storage with technologies for local energy system optimization, including demand response, electric vehicle charging optimization and synergies with other energy vectors at the local level, can offer a cost-efficient pathway (in comparison to high-CAPEX grid upgrade investments) for local energy systems optimization in presence of high volumes of volatile and intermittent RES, since huge amounts of currently non-utilized flexibility can be unleashed to ensure optimal congestion management and effective tackling of local instabilities and imbalances. MERLON introduces an Integrated Modular Local Energy Management Framework for the Holistic Operational Optimization of Local Energy Systems in presence of high shares of volatile distributed RES. Optimization in MERLON applies to multiple levels spanning optimal coordination of local generation, with demand and storage flexibility, as well as flexibility offered by EVs and CHP Plants to facilitate maximum RES integration, avoidance of curtailment and satisfaction of balancing/ ancillary grid needs. MERLON will enable the realization of novel business models, allowing local energy communities to introduce themselves in local flexibility markets, while paving the way for the realization of novel Microgrid-as-a-Service models, assigning to local DSOs the role of “Aggregator of Aggregators” for the provision of added value services to the overlay distribution grid. It equips local stakeholders (DSOs, energy cooperatives, prosumers) with innovative and highly effective tools for the establishment of robust business practices to exploit their microgrids and dynamic VPPs as balancing and ancillary assets toward grid stability and alleviation of network constraints.

Keywords: smart inverter,storage,human centric demand response,flexibility markets,local energy communities and engagement,business models,res integration,self consumption,forecasting,interoperability
Public Diplomacy in Early Modern Europe: Theatrical Entertainments for the State Journeys of English and French Royals into the Low Countries, 1577-1642 (PUBLICDIPLOMACY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

European governments often rely on social media to manage their international relations. This is what scholars of international relations have called Public Diplomacy (PD): the effort of diplomatic actors to influence foreign affairs by reaching out to international audiences through actor-to-public interaction. Rather than being a modern invention, historians such as Helmer Helmers and William T. Rossiter have demonstrated that in the sixteenth and seventeenth centuries printed media were already widely used for PD. Knowledge of this tradition helps to increase historical awareness about ideas and practices of diplomatic communication and collaboration prior to the foundation of the European Union. However, regularly overlooked in scholarship on the early modern history of PD and diplomacy in general is the important role that the performing arts—much like social media today—played in managing foreign affairs. My research project aims to redress the balance and expand knowledge about the diplomatic function and reception of the early modern performing arts within the context of the state journeys that the English and French royal crown made into the Low Countries between 1577 and 1642. Never been studied in depth before, the theatrical entertainments given for the voyages, including tableaux vivants, triumphal processions, and mock naval battles, constitute an excellent example of early modern PD. I will produce the first book-length student to analyse how the theatrical entertainments served as both lubricants in negotiations between representatives of the Low Countries, England, and France, and as tools for promoting collaboration between those countries to a European audience of diplomats, nobles, and commoners. By bringing together the fields of early modern diplomacy and the performing arts, my monograph boasts a genuinely interdisciplinary approach to the state journeys that is essential to understanding the historical development of modern PD.

Keywords: early modern diplomacy,public diplomacy,performing arts,pageantry,royalty,travel,ceremonial entries,low countries,england,france,europe
Ada 2020 | Visual Reasoning Support for Healthcare Professionals (Ada)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 3440450.0
EU funding (EUR): 2408313.25
Participants: 1
Project status: CLOSED

Ada has developed a unique visual reasoning tool for medical professionals that offers diagnosis decision support at the point of care. The award-winning user-interface of Ada is designed to activate the interplay between analytical and integrative thinking skills of the physician. After three years of fundamental research in new reasoning technologies, Ada is now able to capture knowledge from medical experts, transform it into a medical reasoning engine and deliver it directly to the point-of-care in a patient-specific manner. The goal of Ada/DX is to help the doctor: i) avoid misdiagnosis, ii) support diagnosis decision-making for even the most complex cases in a robust and efficient way, iii) simultaneously document the diagnostic process according to both clinical and legal requirements. Reducing the number of misdiagnoses and wrong treatments can help to reduce personal suffering of the patients and healthcare costs simultaniously. A study revealed that misdiagnoses and wrong treatments in the field of vertigo diseases cost about 1 Billion EUR per year in Germany. According to a recent study on the Healthcare decision support field (WinterGreen research – 2013), wrong test and test that are not usefull in a particular situation, account for 30% of the costs of the healthcare delivery in the US. Overall the project will end in a full working Software as a Service (Saas) product. The M10-accuracy of today 85% will be increased to > 95%, by simultaneously increasing the number of common diseases from today 800 to 3.500 plus 6.000 rare diseases. Three user targeted products will be set up, adressing three market segments: GP-Service, Expert-Service, Prevention-Service.

Keywords: healthcare decision support visual reasoning language advanced bayesian inference
CleAnweb Gamified Energy Disaggregation (ChArGED)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Ireland,Greece,Greece,Belgium,Luxembourg
Call: New ICT-based solutions for energy efficiency (H2020-EE-2015-2-RIA, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 2220312.5
EU funding (EUR): 2220312.5
Participants: 11
Project status: CLOSED

ChArGED addresses the energy consumption in public buildings and proposes a framework that aims to facilitate achieving greater energy efficiency and reductions of wasted energy in public buildings. The framework leverages IoT enabled, low-cost devices (NFC or iBeacons) to improve energy disaggregation mechanisms that provide energy use and (consequently) wastages at the device, area and end user level. These wastages will be targeted by a gamified application that feeds personalized real-time recommendations to each individual end user. The design of the game will follow a cleanweb approach and implement a novel social innovation process that will be designed based on human inceptives factors and will help users to understand the environmental implications of their actions and adopt a more green, active and responsible behaviour. The blend of social interaction and competitions with its personalized character are expected to eventually contribute to the user engagement and commitment to generate savings in the long term leading to tackle energy efficiency targets in public buildings while emphasizing on cost effectiveness. Furthermore, users will become more educated on energy efficiency actions and their impacts which has an impact beyond the actual public building. Efficient energy use will render its consumption predictable and this will be exploited by the ChArGED gamified application to optimize use of the micro-generated energy. Users will be motived to reduce energy consumption when power comes from the grid. Predictable energy consumption will also support more informed decisions of micro-generation sources to match the use patterns. The ChArGED solution will be developed with iterative end users representatives’ engagement during analysis, design and development. Further users at least 150 real building occupants in three (3) countries (50 in each building- validation country) will be engaged for deployment and validation.

Keywords: serious games,energy disaggreagtion
Hausa and Kanuri languages as archive for the history of Sahara and Sahel in 18th and 19th century (LANGARCHIV)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany,France,United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2025-11-30
Duration (months): 93.0
Total project cost (EUR): 1497168.0
EU funding (EUR): 1037312.5
Participants: 4
Project status: SIGNED

The eighteenth and nineteenth century history of the central Sahara and Sahel has primarily been written using European or jihadist Arabic sources. This has led to an overwhelming emphasis on religion, politics, and geography as core themes that shaped social and cultural dynamics in this region. By focusing on sources in African languages—until now largely forgotten by historians—the project LANGARCHIV aims to enrich and expand this narrative. Hausa and Kanuri material collected by Germanophone, British, and French scholars for linguistic study between 1772 and 1913 in West and North Africa, England, and Brazil cries out for collaboration between historians, linguists, and anthropologists. This rich body of primary sources remains under-studied, having been rejected as colonial even though the majority were collected before colonial occupation. A general reconsideration of this material will enable a major shift in our understanding, toward a ‘history from below’ that will make it possible to explore the history of Sahelian societies through the stories that Sahelians told about themselves. Serving as linguae francae, in the eighteenth and nineteenth centuries Hausa and Kanuri were spoken from Tripoli to Kano and Bahia, and today Hausa remains the most widely spoken language in West Africa, with 50 million speakers scattered over more than 6 countries LANGARCHIV will be the first project to explore materials in African languages as sources for African history. Combining an epistemological analysis of European scientific interest in African languages with the will to write a social history that overcomes the jihadist bias, the project aims to bring about a paradigmatic shift in the history of the central Sahara and Sahel. It will achieve this goal by revealing a rich body of primary sources and by developing an innovative analytical framework for using documents generated by early students of African languages and cultures as historical sources.

Keywords: history of africa
Comprehensive analysis of yeast expression-fitness functions (EFFs) (YEFF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-05-01
End date: 2020-06-25
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Cellular and developmental processes rely on the precise activity of the proteins that constitute them, and alteration of protein activity often causes disease phenotypes and fitness defects. The relation between protein activity (or expression) and organismal fitness is thus a fundamental genetic property with implications for evolutionary and disease processes. However, a systematic understanding of how protein expression relates to fitness is lacking. Here we propose a comprehensive screen of expression-fitness functions (EFFs) for yeast genes. The proposed inter-disciplinary project will combine cutting-edge methods from synthetic biology, innovative one-step construction of a comprehensive genome-wide library, multiplexed genomics measurements and functional genomics computational analyses to elucidate fundamental patterns of expression-fitness functions. The methodology is based on an inducible degron system that allows for controlled repression of protein levels. Due to a one-fits-all design, the inducible degron can be fused in a one-step transformation procedure to any gene contained in the yeast GFP-fusion library. An all-in-one construction of the library, assessment of library components via deep-sequencing and multiplexed growth and expression assays will allow for the measurement of thousands of yeast gene EFFs in parallel. Computational data analyses will elucidate principal classes of EFFs. Subsequent functional genomics analyses will link principal EFFs to underlying molecular and physiological properties, such as gene’s functions, pathways or cellular localizations, which will therefore provide a foundation to understand the principal causes of how alterations in gene activity translate to impairments of cellular function. The proposed project will therefore open up a new area of systematic, quantitative genetic analysis that should prove crucial in the understanding of human genetic variation and disease.

Keywords: yeast,gene,expression,fitness,gene regulation,evolution,quantitative genetics,disease