Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Formalised Reasoning about Expectations: Composable, Automated, Speedy, Trustworthy (FoRECAST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2030-05-31
Duration (months): 65.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Automatic Differentiation (AD) systems, like TensorFlow, and probabilistic programming languages (PPLs), like Stan, automate complex computations of derivatives and Bayesian inference tasks. By stream- lining these computations for non-expert users, these high-level systems have accelerated progress across science and society (e.g. by enabling machine learning). Yet, the theoretical foundations needed to build a high-level system for composable programming with derivatives and probabilities are missing. This chasm in our knowledge severely limits the implementation of machine learning techniques, preventing them from reaching their full potential. Specifically, we do not understand (a) how to perform AD on programs built using probabilistic choices and expected values or (b) how to compose (i.e. combine and integrate) Bayesian inference algorithms. FoRECAST addresses this chasm by developing programming language theory and tools for flexible, composable, and efficient calculations with derivatives and prob- abilities. WP 1 develops case studies in collaboration with domain experts, to ensure that FoRECAST creates theory and systems relevant to real-world, complex modelling problems. WP 2 develops the semantic foundations, algorithms, and formalised correctness proofs for composable AD of probabilistic programs. WP 3 builds a practical stochastic (i.e. probabilistic) AD system that synthesises these novel gradient estimation techniques. WP 4 establishes theoretical foundations to compose Bayesian inference algorithms in PPLs. WP 5 implements a user-friendly PPL that facilitates composable Bayesian inference, enabling more flexible modelling for a wider user base. By mathematically formalising, generalising, optimising, and implementing a next generation PPL, this project will lay a trustworthy foundation upon which probabilistic data analysis applications (e.g. reinforcement learning, proteomics modelling, and paleoclimate reconstructions) can rise to the next level.

Keywords: semantics,software correctness,probabilistic programming,automatic differentiation
LOcal sound for a new MUSicality. Enhancing musical participation through a local sonic practice (LOMUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-04-30
Duration (months): 26.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: CLOSED

Participation in music-making has shown to produce cognitive and behavioural benefits, enhance social participation, and contribute to shaping both individual and collective identity. However, access to music-making is reserved for people who possess some level of specialised musical training. LOMUS aims at developing a pioneering method that uses easy-to-use Calabrian sounding objects as a tool for facilitating non-trained individuals' participation in music-making: it unlinks music-production abilities from specialised instrumental training to enable non-musicians to make music without requiring mastery of an instrument, of specific musical idioms and techniques. By combining ethnomusicology, contemporary music and community music studies, LOMUS provides a sophisticated understanding of a local sonic practice and investigates how this could inform the emergence of a new global practice for music-making that challenges public conceptions of musicality and of a musician. The research will: study the Calabrian sounding objects to understand how they contribute to shaping the musicality of the community and how they could contribute to creating new types of musicality; investigate contemporary music practices and strategies that can be used to include non-trained individuals in music-making; develop a new method that uses Calabrian sounding objects and contemporary music strategies to enable amateurs and non-trained individuals to make music. The resulting method will be relevant to different rural or urban communities and it can be used to explore elements of a community’s soundscape as an inclusive tool for music-making. LOMUS challenges established concepts and practices around music and musicality, promotes social innovation by initiating new ways of relating with others and the environment through sound, and extends the personal and social benefits of music-making to everybody.

Keywords: musicality,acoustemology,contemporary music,community music,musical engagement,phenomenology of sound,ethnomusicology,composition,psychology of music,amateurs
Demonstrator of systemic solutions for the territorial deployment of the circular economy in the Trilateral Chemical Region with a focus on plastic waste streams Quality for Recycling (SYSCHEMIQ)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Netherlands,Germany,Belgium,Italy,Switzerland
Call: Circular Cities and Regions Initiative (CCRI)’s circular systemic solutions (HORIZON-CL6-2021-CIRCBIO-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 11219362.1
EU funding (EUR): 9573418.0
Participants: 25
Project status: SIGNED

SYSCHEMIQ will demonstrate how to migrate to a circular urban-industrial cross-border district, i.e. the CHEMELOT Circular Hub (CCH) in the Trilateral Euregio of NL, BE and DE. A Circular Economy Action Plan and a (4BEUR) Investment Agenda (2020-2030) are available. Stakeholder involvement schemes are in place, to allow governance within an ecosystem (Regional Government, Municipality, Industries, Educational and Research Institutes, Utilities and Cluster Management): a new way of working to overcome key-bottlenecks. Investment decisions have been made to set up mechanical recycling (4kT/a) and a 150 M€ semi-industrial (18kT/a) chemical pilot recycling plant, to run demos with optimised real-life Mixed Plastic Waste (MPW) streams. We will demo systemic solutions 1) a novel Dual-Track multistakeholder governance model, underpinned by the recently developed Plastic Recycling Impact Scenario: PRISM model (TRL6), and CIMS digital-twin 2) the CCH circular governance model (TRL6), 3) community-based innovation schemes; a Circular City Lab, citizens incentives schemes, incubator and novel skills development and innovation programmes with students (vocational, professional and academic) in a Circular Learning Lab (CHILL), 4) new plastic waste collection, sorting standards/protocols and technologies (e.g. prototype sorting line TRL6) for alignment of material flows in the value chain, 5) new Design rules (TRL 5) for plastic packaging products favouring mechanical and chemical recycling. Considering circa 1.1 Mt of MPW in NL and 30 Mt in EU, scenario calculations promise huge savings of 11.4 Mt CO2 eq./a and 190 kT/a virgin polyolefins. Business modelling and upscaling study will prepare investments in a 100-400 kT/a full-scale recycling facility. A structured Twinning programme with at least 5 selected regions (incl. Flanders and Lombardy), will foster replication, with the support of EU Platform organisations (ECRN, PRE) and in collaboration with the CCRI.
Kabbalah, Philosophy, and Power in the 14th and 15th Centuries Iberian Peninsula (KAPP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-16
End date: 2027-03-15
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

In the two centuries leading up to the Expulsion from the Iberian Peninsula, Jewish communities continuously grappled with internal discord and shifting relationships with Christian rulers and Muslim neighbours. Internally, two significant intellectual divisions took shape: one targeted the nature of knowledge, setting philosophers against kabbalists; the other revolved around the interpretation of Jewish law, split between advocates of symbolic exegesis and proponents of literalism. Additionally, a parallel rift rooted in demographic factors between Jews steeped in Islamic traditions—emphasizing philosophical speculation and esoteric imagery—and those from central European regions—primarily invested in Talmudic studies and pietistic spirituality—increasingly overlapped those intellectual divides. Externally, these same communities were wrestling with the rise of Christian dominance and the waning of Islamic culture. All these tensions are embodied by the Banū Waqār family. Andalusian in origin, they lived in various cities, served the crown, and authored works in different languages on varied subjects. They reached their literary peak with Joseph b. Abraham’s massive yet little-explored “Conciliatory Treatise between Philosophy and Tradition”. This Judæo-Arabic work aimed both to address the pressing intellectual challenges and to mend the communal fabric. KaPP will unfold in two phases: first, a historical exploration of the Banū Waqār family, examining their contributions to the landscapes they inhabited; second, an analysis of the philosophical depth and political ramifications of Joseph’s magnum opus. Through this bifocal lens, KaPP seeks to redefine our understanding of the interplay between these conflicts, illuminating the critical roles that philosophers, kabbalists, and scholars with divergent interpretations of Jewish law played as social forces, thereby rendering age-old debates about the intricate mosaic of medieval Jewish life in new, sharper contours.

Keywords: medieval iberia medieval intellectual history jewish islamic crosspolinations medieval jewish history medieval jewish philosophy jewish studies joseph b abraham ibn waq r
Dissolving microneedle array patch-based psoriatic immunotherapy using nanoparticles (MAPiT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 2
Project status: SIGNED

Psoriasis, an autoimmune disorder characterized by keratinocyte hyperproliferation, predominantly manifests as plaque-type psoriasis, with a majority of cases being mild to moderate. Current treatment approaches, such as topical therapy, often fall short due to limited skin permeability. Systemic drugs and biologics, while effective, pose risks associated with high doses. Addressing mild psoriasis presents the challenge of overcoming limited skin permeability and minimizing systemic drug toxicity. Microneedle Array patches (MAPs) offer a promising alternative. They breach the stratum corneum, facilitating intradermal drug delivery, resulting in higher localized drug concentrations compared to systemic or topical administration. Given the pivotal role of TNF-α in psoriasis, I bring expertise in various MAP fabrication techniques, nanomaterials for drug and mRNA delivery, and their applications. By collaborating with the host, we aim to develop an innovative nanomedicine-based strategy. This approach involves encapsulating TNF-α inhibitors in calcium phosphate nanoparticles using flame spray pyrolysis and loading them into MAPs. The research will encompass various parameters, including size, encapsulation efficiency, release kinetics, mechanical strength, morphology, safety, and in vitro efficacy assessment. Beyond the research project, I will engage in personal development courses, gain exposure to state-of-the-art laboratory facilities, and participate in conferences. Additionally, I will mentor Master's and Ph.D. students, honing my project management skills, and collaborate with industry experts and clinicians to explore the formulation's potential.

Keywords: flame aerosol nanoparticle synthesis,microneedle array patches,psoriasis,nanocarrier,immunotherapy
Towards the automatic identification of exclusionary argumentative biases in contemporary Western art (ArTguments)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-02-29
Duration (months): 30.0
Total project cost (EUR): 345234.9
EU funding (EUR): 345234.9
Participants: 2
Project status: SIGNED

In contemporary Europe, art is used as a means of social exclusion, in contravention of Article 21 (Non-discrimination) of the EU Fundamental Rights Charter. Art is at the centre of exclusionary narratives that directly associate certain forms of artistic expression with dementia and crime, among other controversial issues. Specifically, Western culture has coined the term Outsider Art, along with other derogatory and patronizing labels, to marginalize creators from minority groups, arguing that artworks by those artists are not “meant” to be exhibited in traditional museums and galleries. Using biased arguments, which can be referred to as Exclusionary Arguments, the conventional art establishment questions the legitimacy or authenticity of this type of art and promulgates the idea that it is less valuable than academically recognised art. The ArTguments project seeks to address this issue by developing an automated method for identifying Exclusionary Arguments in the arts, aiming to reduce the entrenched narratives that hinder equitable representation and recognition of all forms of artistic expression in contemporary Western art. This research operates on the hypothesis that Exclusionary Arguments can be identified computationally since they display stable cognitive structures expressed through identifiable linguistic patterns. Hence, the research methodology employed involves applying Argument Mining techniques in order to identify and analyse the Exclusionary Arguments embedded in artistic discourse. ArTguments innovatively addresses exclusion in the art world by introducing Exclusionary Arguments as a novel cognitive and communicative unit, offering a systematic approach to analysing exclusion dynamics within discourse. The project will produce key resources, including a catalogue of best practices with actionable recommendations for promoting an inclusive discourse in museums, and a formal proposal for establishing an Observatory for Inclusive Art Discourse.

Keywords: exclusionary arguments,argument mining,outsider art,inclusion,exclusion,fine arts,argumentation mining,western art,museums,stereotypes
Non-tArgeted foRensic multidisCiplinary platfOrm for inveStigatIon of drug-related fatalitieS (NARCOSIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Innovation actions
Countries involved: Italy,Greece,Finland,Spain,Germany,Portugal,Israel,Poland
Call: A harmonized European forensics approach on drugs analysis (HORIZON-CL3-2023-FCT-01, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 4635295.0
EU funding (EUR): 4410856.25
Participants: 19
Project status: SIGNED

The rapidly changing nature of the New Psychoactive Substance (NPS) market and the overall large number of substances that need to be monitored have presented challenges for early warning activities in recent years. Since the number of illicit drug classes is growing exponentially over time, the current challenge is no longer to search substances during an investigation, but rather to provide a sort of preliminary identification of the substance as illicit, i.e., to tag it as such, especially when it is a new type of drug. Today several instruments equipped with up-to-date libraries allow for the rapid identification of drugs of abuse. However, this approach suffers from four main problems: 1) The instruments’ libraries are not updated regularly; 2) The instruments do not easily overcome the matrix effect; 3) NPSs are trafficked and sold in smaller doses, making their detection and identification more difficult; 4) Routine methods of analysis during forensic analysis are no longer effective in screening drugs of abuse, the parent drugs but also their metabolites, due to the lack of structural information and commercial reference materials. NARCOSIS (Non-tArgeted foRensic multidisCiplinary platfOrm for inveStigatIon of drug-related fatalitieS) will provide a set of features for fast, robust, and reliable multidisciplinary approach to harmonise forensic investigations by means of an up-to-date and updateable diagnostic platform with the following key features: 1) A set of selected orthogonal instruments operable both on-site and in laboratories (Raman/SERS, IR, HSI, HRMS) will be adapted to be used with the NARCOSIS platform; 2) Build a comparable and shareable (cross-organisation) reference spectra (meta-spectra) database for faster detection and identification of drugs of abuse; 3) Create an AI-assisted spectra management and integration toolkit for analytical measurements to support the EU Early Warning System to rapidly detect, assess and respond to NPS.

Keywords: new psychoactive substance,spectroscopy,mass spectrometry,hyperspectral imaging,artificial intelligence,early warning system
RESILIENT MEDIA FOR DEMOCRACY IN THE DIGITAL AGE (ReMeD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,Germany,Ireland,Czechia,Norway,Austria,United Kingdom
Call: Media for democracy – democratic media (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 2592095.0
EU funding (EUR): 2592095.0
Participants: 9
Project status: SIGNED

Resilient Media for Democracy in the Digital Age (ReMeD) responds to the European Commission’s call HORIZON-CL2-2022-DEMOCRACY-01-06: “Media for democracy – democratic media”, and will tackle existing challenges to a healthy relationship between media and democracy, by taking a bold approach to improve relations between citizens, media and digital technologies. With an interdisciplinary approach and an innovative methodology that combines qualitative and quantitative methods, ReMeD will gather, analyze, compare and contrast data on professional journalists, alternative media content producers and citizens operating in technologically mediated configurations, and on the media organizations, market structures and national and international regulations that underpin media production, circulation and consumption in the contemporary media landscape. ReMeD will work closely with all parties involved in order to co-produce high-impact knowledge and solutions that will contribute to the creation of resilient democratic media that reinvigorate, strengthen and uphold democracy, the rule of law and fundamental human rights. The project is particularly timely as ReMeD’s results and policy recommendations will feed directly into the contemporary debates around the design and implementation of the Digital Services Act and Digital Markets Act.

Keywords: democracy,resilience,new media consumption,transparency,hybrid media system
GLP1-R Agonists in Pregnancy- Impact on Baby's Brain (GAPIBB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-06
End date: 2027-05-05
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

Obesity and associated metabolic diseases represent a significant health challenge and financial burden worldwide. Recently, a breakthrough has been made in the treatment of obesity with drugs such as semaglutide (Ozempic), which mimic endogenous glucagon-like peptide 1 (GLP1) action in the brain and cause weight loss via reduced food intake. The hypothalamus is the key brain region involved in the neuronal control of food intake. Recent research shows that perturbations to the maternal environment in pregnancy may interfere with early neural circuitry development in offspring and lead to life-long metabolic impairments that are a contributing factor of rising obesity rates. The increased Ozempic use in women of reproductive age has resulted in a rise in “Ozempic babies”, where women unexpectedly become pregnant whilst using Ozempic. However, there is limited data regarding Ozempic use in pregnant women to determine whether in utero exposure leads to adverse developmental effects in offspring. The offspring hypothalamus is potentially vulnerable to semaglutide exposure, due to it’s highly plastic developmental state and high GLP1R expression in both rodents and humans. This project is designed to test the hypothesis that in utero Ozempic exposure causes significant alterations to the development of hypothalamic feeding circuitry resulting in subsequent disruptions to metabolic control in the offspring. Using a rodent model of semaglutide administration to the mother in pregnancy, we will determine whether semaglutide exposure during fetal development affects hypothalamic circuitry and transcriptome at different ages from fetal through to adult life and evaluate whether semaglutide exposure causes long-term changes in metabolism or feeding behaviour in offspring in adulthood. This project will deliver vital insight into the long-term effects of semaglutide use in pregnancy on long-term offspring health.

Keywords: developmental programming,hypothalamus,semaglutide,obesity