Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Using Single-Cell Transcriptomics to identify the Diatom Silica Morphogenesis Machinery (DiaMorphy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Diatoms are a large group of unicellular, eukaryotic microalgae that biosynthesize SiO2 (silica)-based cell walls (frustules). They are ubiquitously present in aquatic habitats and key primary producers in the oceans, contributing 20% of the annual photosynthetic CO2 fixation on earth. The architectures of frustules are species specific, displaying intricate patterns of nano- and microscale features, and are believed to be of prime importance for the ecological success of diatoms. Furthermore, in biomineralization research, diatoms serve as model systems to reveal the mechanisms by which organisms are able to generate inorganic materials with complex architectures. Such insight holds the promise of gaining advanced capabilities to synthesize minerals with tailored properties using an environmentally benign processes. During the past two decades, numerous candidate proteins potentially involved in diatom silica biogenesis have been put forward, but only a small number of these have been confirmed to be required for this process. The DiaMorphy project aims to identify the complete set of proteins required for silica morphogenesis in the model diatom Thalassiosira pseudonana. To achieve this, the project will inverse the conventional approach by analyzing silica biogenesis in induced morphological mutants of T. pseudonana rather than in the wild-type. For the first time, single-cell transcriptomics will be applied to study gene expression at specific stages during silica biogenesis. Comparative analysis of the resulting, highly refined transcriptomics datasets, is expected to 'crystallize' a comprehensive core set of silica morphogenesis genes. In proof-of-principle experiments, selected proteins from this core set, will then be functionally characterized in vivo using state-of-the art genetic engineering techniques.

Keywords: biomineralization,diatoms,single cell transcriptomics,morphogenesis
Building Resilience Through Citizen Science-Driven Approaches to Invasive Species (BUILDERS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Austria,Portugal,Belgium,Romania,Croatia,Brazil
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 729312.86
EU funding (EUR): 716430.0
Participants: 11
Project status: SIGNED

Fostering resilience in ecological systems is a cornerstone of European Union programs (e.g. Climate, Environment & Maritime) aimed at ensuring a sustainable future, especially when we consider the ecological disruptions determined by the spread and establishment of Invasive Alien Species (IAS). They pose a formidable threat to global biodiversity, undermining the resilience of ecological stability and exerting substantial pressures on vital ecosystem functions and services. In Europe alone, an estimated 11% of approximately 12,000 introduced species are classified as invasive, inflicting extensive environmental, economic, and social harms. Recent assessments highlight that it will be difficult to achieve the ambitious goals of the EU Biodiversity Strategy for 2030 in terms of reducing the impacts exerted by IAS due to the inadequate level of knowledge and the fragmentation of competencies. As a result, we need to reconsider management strategies for IAS, demanding for more integrated, effective knowledge that encompasses multidisciplinary, inter-sectoral, and international dimensions. To achieve this, the project BUILDERS has the ambition to combine three pivotal disciplines: (i) Citizen Science, (ii) the study of animal behaviour and (iii) the bio-functioning monitoring. The integration of the respective approaches not only innovatively addresses the complex challenges posed by IAS - overcoming disciplinary barriers - but also promotes the career advancement of researchers and professionals in the field at various stages. The objective of BUILDERS is to provide advanced training opportunities through a network of 7 academic and 4 non-academic partners spread across 6 European countries—Austria, Belgium, Croatia, Italy, Portugal, and Romania—and Brazil.

Keywords: citizen science,invasive alien species,resilience,nature protection
Ideal-ist transnational NCP project. (IDEAL-IST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Israel,France,Greece,Poland,Portugal,Bosnia and Herzegovina,Georgia,North Macedonia,Iceland,Slovakia,Estonia,Spain,Romania,Czechia,Türkiye,Belgium,Finland,Italy,Croatia,Netherlands,Norway,United Kingdom,Cyprus,Hungary,Austria,Germany,Luxembourg,Moldova, Republic of,Lithuania,Latvia,Switzerland
Call: Support for transnational activities of National Contact Points in the thematic area of Digital (CSA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-03-01
End date: 2025-08-31
Duration (months): 42.0
Total project cost (EUR): 2568651.25
EU funding (EUR): 2470442.0
Participants: 33
Project status: SIGNED

The Ideal-ist project will give all NCPs with responsibility for the digital destinations in Horizon Europe Cluster 4 (3, 4 and 6) access to the knowledge, tools, and experiences they need to ensure top quality services to their clients. In turn, these services can result in inventive, catalytic European projects. Over 30 NCP teams will pursue this ideal working together and operating across national boundaries, resulting in stronger services exceeding the capacity of a single organisation in a purely national context. Ideal-ist has clear objectives to meet this goal: O1: Access to a rich knowledge base on the digital landscape of opportunities. O2: Offerings that improve and expand their working tools and services. O3: Interaction among proposers, NCPs, the Commission and strategic partnerships on a personal level that enhances expertise and participation. The objectives translate to four sets of activities: 1. Manage, share and maintain Ideal-ist's knowledge base during and beyond the adjustment to Horizon Europe, according to the FAIR principles and in cooperation with Bridge2HorizonEurope. 2. Strengthen the sense of community and teamwork among digital NCPs and other Cluster 4 NCPs. 3. Offer services specifically designed for digital NCPs and try their application in the other areas of Cluster 4 4. Offer proposer-oriented services, focusing on the digital parts of Cluster 4, and try their application in the other areas of Cluster 4. Activities will be monitored using an agile methodology via an Activity Execution Dashboard (AED), allowing the project to deliver activities and tasks, identify deviations and propose corrective actions, measure progress towards success and quantify impact to achieve the high-level objectives. Ideal-ist will enrich the designated activities of NCPs with transnational activities going beyond national mandates, contributing to enhanced natural cooperation, leveraging the services and creating economies of scale.

Keywords: digital,ncp network,topic tree,proposers services,activity execution dashboard
SEROLOGICAL TESTING AND TREATMENT FOR P. VIVAX: FROM A CLUSTER-RANDOMISED TRIAL IN ETHIOPIA AND MADAGASCAR TO A MOBILE-TECHNOLOGY SUPPORTED INTERVENTION (PvSTATEM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Australia,France,Ethiopia,Madagascar,Ireland,Switzerland,United Kingdom,Italy,Poland
Call: Innovative approaches to enhance poverty-related diseases research in sub-Saharan Africa (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 7290778.13
EU funding (EUR): 7290778.13
Participants: 9
Project status: SIGNED

P. vivax is considered the most difficult human malaria to eliminate because of the inability of conventional diagnostics to detect individuals with latent liver forms. These individuals account for 80% of all infections and can readily infect mosquitoes. Currently countries can test knowing this has little impact or and the treat everyone which exposes individuals to drugs with potentially dangerous side effects. Parasite specific antibody responses have been shown to correlate with the likelihood of hypnozoite carriage and can be used to identify individuals who should be treated. Aim is to implement a Cluster-Randomised Trial in Ethiopia and Madagascar to demonstrate the effectiveness of a new anti-malaria intervention based on Plasmodium vivax serological testing and treatment (PvSTATEM) with primaquine to prevent the relapse infections responsible for maintaining P. vivax transmission. Simultaneously, we will assess social and health system acceptability of such an approach as well as refine new mobile technologies which interface with point-of-care diagnostic tests and guide treatment decisions. We aim to reduce malaria burden at both the individual and population level in two countries which experience the highest levels of P.vivax in Africa. We expect to have a significant effect in reducing morbidity and improving health. We will ensure community engagement and assess the adoption of new technologies that align with those existing in the health system. The proposal is built on equal partnership and shared capacity to address a substantial public health burden.

Keywords: malaria,serology,p vivax,ethiopia,madagascar,primaquine
Validating Biodegradation Rates and Reactions Applying Novel Technologies and Systems Ecology Approaches (ViBRANT-SEA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 3499350.0
EU funding (EUR): 3499349.75
Participants: 2
Project status: SIGNED

Plastic Marine Debris (PMD) is now considered a planetary boundary threat and the “Plastic Cycle” a biogeochemical cycle. The impacts of single-use plastic litter in marine environments have prompted a search for greener alternatives such as the biodegradable/compostable plastics polyhydroxyalkanoates and polylactic acid already being used for consumer goods. The diversity of microbes, their enzymes, and their role in influencing the rates of plastic biodegradation in nature remains poorly characterized – particularly in cold or low-oxygen marine waters and seafloor, where most PMD accumulates. The impact of lag duration, pH, hydrostatic pressure, and potential priority effects of initial microbial colonizers remain vital but unaddressed concerns. In addition, the impact of plastic, its breakdown products, and additives on marine organisms and ecosystems is largely unquantified. Two urgent questions are how long does plastic last in the marine environment and what are the impacts on ecosystems. This technology-enabled project aims to quantify biodegradation rates of biodegradable plastics and plastic-associated additives in the field and under controlled laboratory conditions, and to develop a fish model system for toxicity tests to fill these knowledge gaps. This project will generate novel microbial metagenomes from global plastic samples collected during cruises and from biodegradation experiments to create a comprehensive list of genes and enzymes linked to biodegradation of biodegradable plastic in marine environments. It will be the first to combine in situ respirometry, stable isotope probing, and advanced imaging techniques to measure biodegradable plastic biodegradation rates while visualizing microbe-microbe interactions on the plastic surface, revealing cellular mechanisms occurring during active biodegradation. Finally, it will develop the first marine fish organoid model for consistent and efficient testing of toxicity due to plastics and additives.

Keywords: biodegradation,plastic pollution,microbial ecology,genomics,ecotoxicology,organoids
Econometric Models to Evaluate Environmental and Spatial Effects of Long-Lasting Policies (SPACETIME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1413500.0
EU funding (EUR): 1413500.0
Participants: 2
Project status: SIGNED

Policies often target one market: road taxes target commuting, agricultural subsidies target farming, and car taxes target the automobile market. Economists developed a rich toolbox to evaluate the effects of policy in the targeted market in a partial equilibrium analysis. However, policies are often long-lasting and massive in scale, affecting where economic activity occurs. The spatial distribution of activity matters in agriculture and transport because of the environmental externalities of land use, congestion, and pollution. This proposal presents an econometric methodology to study the interaction between policy and the spatial distribution of economic activity. The proposal presents a collection of large-scale spatial data that combine individual choices with aggregate outcomes and proposes a methodology that connects partial equilibrium evaluation of policy with spatial general equilibrium models. The first project illustrates how we can use a combination of data on individual travel choices and aggregate outcomes on traffic equilibria to estimate a structural econometric bottleneck model of congestion. The second project presents a methodology to investigate how the Common Agricultural Policy and Natura 2000 affect land use in the European Union. The Common Agricultural Policy has provided income support to almost 10 million European farmers since 1962. Natura 2000 protects 17% of Europe's terrestrial landmass. Subsidies in one region affect farmers in another through the open EU agricultural market. The third project evaluates policy that affects transport mode costs, such as company car taxation. Company cars receive an implicit subsidy of 50% and represent half of the new vehicle sales in several EU countries. Such subsidy to commuting by private vehicles impacts the spatial distribution of workers and firms. The location choices and resulting commuting patterns drive the policy's carbon, congestion, and pollution externality effects.

Keywords: policy evaluation,structural econometric methods,spatial general equilibrium,congestion,agriculture,transport,automobiles,empirical industrial organization,environmental economics
Single-Photon Light Sources for Quantum Technologies (QTOOL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Denmark
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-04-01
End date: 2024-09-30
Duration (months): 30.0
Total project cost (EUR): 3579225.0
EU funding (EUR): 2490742.63
Participants: 1
Project status: CLOSED

Despite monumental advancements in IT, our computers remain very inefficient in solving many of the most crucial and complex challenges we are facing. This is the vision of Quantum Technologies and one of the most promising platforms is based on single quantum particles of light, i.e., single photons. So far, high-fidelity single-photon sources were not commercially available until Sparrow Quantum (SQ) introduced its beta-version single-photon chip – the world’s first commercially available single-photon light source. Our technology builds on world-leading in-house expertise on quantum optics and nanofabrication, and exclusively licensed patents from NBI in Copenhagen. QTOOL objective is fine-tuning and demonstrating a set of key single-photon products. They will enable researchers in Photonic Quantum Technologies to carry out their research in faster, cheaper, and better ways, and enable technologies and components that are impossible with any currently available light sources.

Keywords: quantum photonics,quantum computing,pharmaceutical quantum simulation,quantum simulators,quantum cryptography,integrated photonics,quantum technologies,single photon sources,quantum sensing
Leading Utility-scale RES Market Expansion towards Next-generation Energy Systems (LUMENS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Spain,Poland,Belgium,Italy,Portugal,Slovenia,Greece
Call: Market Uptake Measures of renewable energy systems (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 2577839.29
EU funding (EUR): 1999506.25
Participants: 9
Project status: SIGNED

Although decentralized and utility-scale renewable energy sources have grown, the EU must speed up their deployment to meet decarbonisation targets. Outdated grid infrastructure, limited system flexibility, complex regulatory frameworks, and rising NIMBY attitudes hinder the full market integration of these plants, affecting their business models and service monetization. Addressing these issues is essential for both facilitating the deploying of new utility-scale RES plants and maintaining previously existing ones and its viability. To achieve this, LUMENS will implement a comprehensive strategy built on three key pillars: (1) Establishing a multi-actor engagement framework to ensure a strong stakeholder dialogue and capacity building, providing the project with valuable feedback from the sector. (2) Creating a dynamic repository of knowledge transfer materials (KTM), including success stories and recommendations based on a portfolio of cases that will be studied throughout the development of LUMENS, as well as an open-source toolkit composed by analytical and decision-support tools that will aid in a variety of aspects, such as location, sizing, hybridization or market performance prediction of a RES plant. (3) Executing a continuous knowledge transfer strategy that promotes direct interaction with key international market players. With a consortium of nine partners from seven EU countries, including market operators, power system operators, RES promoters, and multidisciplinary research experts, LUMENS is well backed up to develop actionable insights for optimizing key factors including the planning, location, operation, and monetization of utility-scale RES plants among others. Ultimately, LUMENS seeks to enhance the competitiveness of RES plants in the EU energy market, particularly utility-scale infrastructures, by promoting secure, cost-effective energy solutions and advancing the path toward net-zero emissions.

Keywords: not in my backyard,not in my grid,market uptake of res,market dynamics,utility scale plants,financial frameworks,social acceptability,stakeholder engagement,environmental impact,res,bess
MRI analysis tool for early detection of dementia (MATEDD)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Estonia
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-04-30
Duration (months): 11.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Worldwide due to population ageing there will be 75 million patients with Alzheimer's disease by 2030. Alzheimer's is a disease described by accelerated brain ageing which leads to decline in both memory and cognitive skills, thus affecting everyday activities of those suffering. On average over 60% of patients do not receive a diagnosis and average cost of misdiagnosis is estimated to be over 2K €. Existing screening and early diagnostics methods lack speed and accuracy, are not automated enough, and detect only already existing symptoms when it is late for prevention. At Neurosalience we develop a software for assessing brain ageing for early detection of Alzheimer's disease from low-resolution MRI and CT scans. Measuring subject’s brain age and extracting important features for making a prediction are used to assess the risk of Alzheimer's disease. The tool determines whether patient has Alzheimer's along with its stage and type of dementia. We aim at supplying healthcare providers with a more accurate, cheaper and faster early diagnostic tool for Alzheimer's disease. The tool allows decreasing patient-related costs and improving the quality of life of patients. The tool is first in the world to be capable of processing even low-resolution MRI data and providing interpretable results over whole brain. With the support of the Women TechEU programme we will boost the market readiness of the Neurosalience tool by developing the project both from business and regulatory perspectives. For this purpose, we plan to develop a pricing model for the tool, improve deep learning models used in the product and prepare all the documentation along with quality management system required for regulatory approval. We would benefit from the Women TechEU services of mentoring and coaching on how to support and run investor relationships. As we plan to set up partnerships with hospitals, we would also benefit from advice on running such partnerships in the healthcare.

Keywords: health technology,dementia,innovation for the problem of ageing population