Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding forest growth dynamics using novel 3D measurements and modelling approaches (3D-FOGROD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Forest ecosystems are an essential terrestrial carbon sink, and deforestation and forest degradation account for about 12% of global anthropogenic carbon emissions. However, estimates of the global distribution of terrestrial carbon sinks and sources are highly uncertain. Constraining the inaccuracy of carbon estimates is essential to support effective forest management and future climate mitigation. A better understanding of forest growth dynamics will improve our understanding of the carbon cycle and mechanisms responsible for terrestrial carbon sources and sinks, reducing uncertainties on their magnitude and distribution. In the 3D-FOGROD project, I aim to improve our understanding of forest growth dynamics and evaluate the role of elevated CO2 levels on forest growth. I will achieve this by using novel 3D laser scanning (LiDAR) techniques, unique datasets and state-of-the-art modelling approaches to (1) accurately quantify forest growth using terrestrial LiDAR data in a free-air CO2 enrichment experiment; (2) improve historical and future simulated forest growth dynamics using LiDAR derived forest structure for a range of forest ecosystems; and (3) develop and disseminate recommendations for climate mitigation actions to policy makers based on new insights in forest growth dynamics and carbon cycling. The proposed scientific innovation and applicability will benefit the EU not only by generating new knowledge and publications in high-profile scientific journals, which will contribute to the enhancement of EU scientific excellence, but also by contributing to EU commitments to the Paris climate conference (COP 21) agreement that aims to limit the increase in global temperature to 1.5°C. The science excellence and training through 3D-FOGROD will enable me to apply for senior research positions or an ERC starting grant in the future, which would allow me to establish my own research group focused on 3D terrestrial ecology.

Keywords: forest growth,lidar,terrestrial laser scanning,vegetation modelling,co2 enrichment experiment,climate change,science policy,carbon cycling,3d structure,above ground biomass
Strawberry Processing Machine (SPM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Portugal,Portugal
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The fruit and vegetable processing market is growing exponentially driven by the increasing demand of frozen products, juices and ready-to-use products. In this context, industries that process very sensitive fruits are facing great difficulties/ challenges to increase their competitiveness. Indeed, this segment is unable to fully benefit from the industrial technologies like automation and artificial vision - already used in other segments - to increase the productivity, the quality and the safety of the final product as well as working conditions. Attempts have been made for this purpose but solutions proposed until now are not enough automated resulting in low processing cadence and thus, high payback period of the machine. In order to address these concerns, Orizon Vision and AcessoMatic combined their skills, respectively in artificial vision and automation, to develop an innovative machine able to automatically manipulate and cut the green zone or calyx of at least 10-12 strawberries of all caliber per second. In this case, our artificial vision software will identify with precision by colour the cutting zone on the strawberry duplicating the processing cadence of existing solutions. By reaching first the strawberry market that increased 16% a year in the last 10 years, our goal is to expand this technology to the processing of other very delicate fruits or vegetables like persimmons, figs, peaches, etc. This innovation project constitutes a great opportunity for the participating companies, Orizon Vision and AcessoMatic, to develop a high value and disruptive solution which can reinforce their position in the market and increase their visibility around the world. For that purpose, we need to refined and matured our initial business plan. Hence, the feasibility study would significantly leverage our business proposition to reach the market and enhance the possibility of successfully applying to Phase 2 in the SME Instrument in order to demonstrate our machine.

Keywords: food processing,food industry,food safety,artificial vision,automation
EELISA INNOvation and COmmon REsearch strategy (EELISA innoCORE)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Germany,Italy,Spain,Türkiye,Hungary,Romania,France,France
Call: Support for the Research and Innovation Dimension of European Universities (Part II) (H2020-IBA-SwafS-Support-2-2020, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 1999950.0
EU funding (EUR): 1999950.0
Participants: 11
Project status: SIGNED

The European Engineering Learning Innovation and Science Alliance (EELISA) is a bottom-up alliance of higher education institutions representing more than 180,000 students and 50,000 graduates each year, 16,000 faculty members and 11,000 administrative staff. EELISA is one of the European Universities selected by the European Commission under an Erasmus+ call. With EELISA we are initiating an unprecedented level of institutionalised cooperation between our institutions in order to gradually achieve our long-term vision: the education of European Engineers. Now we see an opportunity to transform our R&I dimension with EELISA INNOCORE. Our plan is built on the ecosystem of EELISA communities created to transform higher education, and comprises three main steps: 1) Make our researchers and innovators know each other, create spaces for dialogue with citizens and with non-academic actors and set up a portfolio of shared scientific infrastructures; 2) foster and support the development of joint R&I actions and the creation of new structures (research groups, clusters, joint labs, start-ups, scientific parks) and 3) optimize the outreach of these actions. In parallel, we work on a common strategy on open Science, we assess the costs and benefits of actions and deploy plans to promote gender equality, diversity and citizen science.

Keywords: european university,research,innovation,open science,citizen science
Towards a more automated and optimised maintenance, renewal and upgrade of roads by means of robotised technologies and intelligent decision support tools (OMICRON)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Spain,Italy,Spain,Spain,Greece,Hungary,United Kingdom,Portugal
Call: Enhancing coordination between Member States' actions in the area of infrastructure research with a particular focus on biodiversity and ameliorating environmental impacts and full automated infrastructure upgrade and maintenance (H2020-MG-2020-TwoStages, 2020)
Start date: 2021-05-01
End date: 2024-10-31
Duration (months): 42.0
Total project cost (EUR): 4999380.0
EU funding (EUR): 4999380.0
Participants: 20
Project status: SIGNED

The objective of OMICRON is to develop an Intelligent Asset Management Platform with a broad portfolio of area-specific innovative technologies to enhance the construction, maintenance, renewal and upgrade of the European road network. This project will improve the whole asset management pipeline focusing on four pillars: the implementation digital inspection technologies; the development of a road Digital Twin; the construction of a Decision Support Tool; and the development of smart construction and intervention solutions for road infrastructures. OMICRON’s Intelligent Platform will be interconnected by a BIM-oriented Digital Twin linked to the Decision Support Tool, which will enable the industrialisation and automation of a number of road management tasks which currently still have a high labour component. OMICRON’s developments will address the entire road network system including pavement, bridges, tunnels, lighting or signalling systems. These improvements will result in a) an increase of the safety levels in road intervention actions, affecting both road users and personnel; b) an increase in the capacity of the road network; c) an overall improvement of the efficiency of road intervention processes; and d) a subsequent reduction of maintenance costs. The group of technologies developed in the project will be implemented in a virtual demo and four real demonstrators that belong to CEF corridors from two European countries: Spain and Italy. The technologies developed in OMICRON will achieve a TRL 7 after the demonstration phase. The consortium is formed by 16 partners from 7 EU countries, including road managers and associations; emergency, routine and extraordinary maintenance contractors; civil engineering companies; smart solution developers; drones and robotics experts; research centres; universities; ICT developers and integrators; communication and dissemination managers; business model managers and innovation and project managers.

Keywords: transport,digitalisation,inspection,maintenance,upgrade,industrialisation,safety,standards,decision support tool,data analysis,digital twin,drones,traffic,capacity,cost
The Making of Ottoman Law: The Agency and Interaction of Diverse Groups in Lawmaking, 1450–1650 (OTTOLEGAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Türkiye
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1998785.0
EU funding (EUR): 1998785.0
Participants: 1
Project status: SIGNED

This project investigates the formation of law in the Ottoman Empire between 1450 and 1650. Examining the religio-legal opinions (fetva) of scholars and decrees of sultans (kanun), it aims to expose the hybridity of Ottoman law by revealing the agency and interaction of diverse groups in the lawmaking process, moving beyond the well-known role of such actors as the government (the sultan and his representatives) and scholars to better understand the role of other, lesser-known actors like local groups with entrenched interests, non-Muslim communities, common people, founders of endowments, guilds, merchants, and others. Previous scholarship in the field has mainly utilized fetva and kanun as fixed legal categories, respectively representing the order of sacred law (sharia) and the will of the sultan. This project departs from this view, instead treating both fetva and kanun as malleable media that provided languages for the articulation and hybridization of diverse legal views. Approaching the study of the Ottoman legal history from a new perspective, OTTOLEGAL scrutinizes a large corpus of kanun and fetva texts with particular research questions that are expected to reveal the agency and interaction of multiple groups and their ideas in the formation of law. Additionally, the project aspires to develop a model of lawmaking that will account for diversity and change across time and space in early-modern societies. The OTTOLEGAL team will prepare a database with a web portal, including metadata, description, transliteration, translation, and essays of scholarly analysis for the key sources of the project. In addition, three monographs and one sourcebook will be written and published, and two international conferences will be organized and their papers published in two edited volumes. This project promises to recast the field of Ottoman legal history on the basis of a new perspective and open new frontiers in the study of history and law.

Keywords: ottoman empire,global history
INnate-ImmunomeTabolIsm as Antiviral TargEt (INITIATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Ireland,Austria,Austria,Germany,Norway,Sweden,France,Netherlands,Netherlands,Netherlands,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-05-01
End date: 2023-04-30
Duration (months): 48.0
Total project cost (EUR): 4054106.16
EU funding (EUR): 4054106.16
Participants: 14
Project status: SIGNED

Viral outbreaks and epidemics continue to impose high morbidity and mortality burdens in mankind and animals, emphasizing the urgent need for the continuous improvement and innovation of our antiviral strategies. The innate immune system is pivotal for effective anti-viral defences. This field is now being revolutionised by the recognition that metabolic re-programming has a major impact on the host antiviral and inflammatory response to virus infections. The development of strategies targeted to these pathways represents an exciting new frontier for antiviral remedies. To drive this emerging field of antiviral immunometabolism and its application to viral diseases, INITIATE (INnate-ImmunomeTabolIsm as Antiviral TargEt) brings together a highly complementary team of world leaders, both academic and corporate, from the historically distinct research fields of virology, innate immunity and cellular metabolism in order to train a new generation of interdisciplinary scientists. Specifically, INITIATE will deliver training on the interrelationships between viral infection, host metabolism and immune defences through related and interdependent research projects, complemented with interdisciplinary and intersectoral secondments. Local and network-wide scientific workshops will be supplemented with transferrable skill workshops devoted to academia/industry collaboration, research dissemination and translation of knowledge into novel therapeutic interventions, public engagement and a successful research environment. INITIATE will result in a new generation of creative, entrepreneurial and innovative top-level interdisciplinary researchers, who will be at the forefront of the emerging research field of ‘antiviral immunometabolism’. These scientists will be able to face the inevitable future challenges in combating viral and other diseases, and they will be highly attractive to European Life Sciences industry and academia.

Keywords: antiviral immunometabolism,rna viruses,in vivo models and human primary cells
Multidisciplinary European training network for development of personalized anti-infective medical devices combining printing technologies and antimicrobial functionality (PRINT-AID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Belgium,Belgium,Poland,Finland,Finland,Netherlands,United States,Netherlands,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 2265900.12
EU funding (EUR): 2265900.12
Participants: 13
Project status: CLOSED

According to ECDC, over 4 million healthcare-associated infections in the EU cause 37,000 deaths and cost EUR 7 billion/year. Half of them are related to medical devices (i.e., catheters, implants) and 80% of these are related to bacterial biofilms. A recent EC report highlighted the medical device sector’s role in driving EU economic growth, employing 500k people in 25k companies (80% are SMEs) with annual sales of EUR 85 billion. The strategy to prevent medical device-infections is alteration of the device’s surface with antimicrobials. However, current antimicrobial surfaces don’t control bacterial growth in tissue surrounding implants, and only Sterilex® has received regulatory approval in the US as anti-biofilm agent. Participants in this proposal have earlier demonstrated a dramatic in vitro inhibition of biofilm formation by 3D-printing surfaces with antibiotics incorporated into the carrier polymers. This discovery opens new possibilities for printed medical devices that better resist biofilms. Our objective is to set-up a new European education platform to guide and inspire young researchers in the intersectoral exploration of innovative routes to counteract microbial biofilms by fabricating anti-infective, tailored, 3D-printed medical devices. Current opportunities for young researchers to receive an structured, inter-sectoral and up-to-date education on personalized medicine and medical devices are marginal, and to our knowledge PRINT-AID is the first ETN set up for this purpose. State-of-the-art printing technologies will be combined with in vitro and in vivo biofilm models and novel tools for data integration/standardization. Doctoral training will be performed within a high-quality network of 12 participants (5 industrial) from the EU and US. It will include online and face-to-face courses taught by researchers with academic and industrial expertise in biofilms, 3D-printing research, antimicrobials, material science, and drug development.

Keywords: microbial biofilms,anti biofilms,medical devices,personalized medicine,pharmaceutical technology,printing technologies,3d printing,bioinformatics,animal anti infective models
Targeting Shelterin Proteins in Cancer (SHELTERINS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 2495466.25
EU funding (EUR): 2495466.0
Participants: 1
Project status: SIGNED

Telomeres are protective structures at the chromosome ends essential for genome stability. Telomere biology is intricately linked with human cancer. Most cancer cells reactivate telomerase to avoid telomere loss associated to cell division. Targeting telomerase inhibition in cancer has shown very limited efficacy, alternative or additional mechanisms of telomere maintenance are thus at play in cancer. Recent evidence shows that components of the telomere-protecting shelterin complex are mutated in cancer. Shelterin prevents chromosome fusions, impedes persistent DNA damage response at telomeres and regulates telomerase activity. We were first in describing shelterin mutations in cancer and pioneered the idea of targeting shelterin as an anticancer strategy to induce length-idependent telomere damage. We also found that key cancer pathways regulate shelterin function throughout post-transcriptional modifications. Developing new therapeutic approaches based on targeting shelterin is hampered by lack of mouse models and incomplete understanding of which underlying mechanisms mutations in shelterin drive tumour development. We strive to establish a comprehensive set of tools, to enable us to conduct a fundamental and far-reaching experimental programme on the role of shelterin in cancer. Our specific aims are to i) generate knock-in mice to understand the role of POT1 shelterin mutations found in cancer and develop personalized therapeutic strategies based on these alterations, ii) generate knock-in mice to understand the role of post-translational modifications of the TRF1 shelterin by several cancer pathways for the identification of new cancer targets, and iii) dissect the potential role of TRF1 in cancer stem cells. We expect to block the ability of cancer cells to divide indefinitely and effectively impair cancer growth. Our research programme will reveal the role of two fundamental aspects of biology, telomere capping and chromosomal stability, in cancer.

Keywords: telomeres,cancer,telomere integrity,cancer stem cells,shelterin proteins,mouse models,pot1 mutations,trf1 post translational modifications,crispr cas9 technology
Tackling the complexity of Tidal Disruption Events (TackTDEs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

When a star gets too close to a supermassive black hole, it gets disrupted by the strong tidal forces of the compact object. A few dozen of these tidal disruption events (TDEs) have been discovered to date and a much larger number is expected from current and near-future missions. The observed signal contains rich information about the mechanisms and conditions at play around black holes in otherwise quiescent galaxies. A full exploitation of the huge predictive power of TDEs urgently requires to improve our understanding of their dynamics and the associated emission. Through a combination of analytical and numerical tools, the proposed research aims at studying the different phases of these events considering crucial physical processes missing from previous investigations. After the star has been disrupted, the debris evolves into an elongated gas stream that partially falls back towards the black hole. The researcher will determine how the geometry of this matter evolves under the influence of stellar magnetic field and rotation. As this stream comes back to pericentre, general-relativistic effects cause it to self-cross, which initiates the formation of an accretion disc and could participate to the emission of TDEs in the optical and UV bands. The researcher will determine the influence of the black hole spin on this process, focusing on the delay of stream-stream collision induced by Lense-Thirring precession. He will also investigate photon diffusion during disc formation to determine the evolution of the emerging shock-powered lightcurve. After the gas has settled, viscous torques drive the accretion of the stellar matter onto the black hole, producing X-ray radiation. The researcher will study this ultimate phase to evaluate the energy output and the origin of angular momentum transport in TDEs. This work will result in great advances in this research field on the theoretical side that will be used to better exploit observational data.

Keywords: tidal disruption events,transient astrophysics