Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The missing link: how do membrane lipids interplay with ATG proteins to instruct plant autophagy (LIP-ATG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-07-31
Duration (months): 66.0
Total project cost (EUR): 1499880.0
EU funding (EUR): 1499880.0
Participants: 1
Project status: SIGNED

Autophagy is an intracellular catabolic process critical to eukaryotic life and indispensable for plant survival to drought, nutrient scarcity or pathogen attacks. Autophagy relies on the formation of specialized vesicles called autophagosomes (AP) which engulf and deliver cell components to the lytic vacuole. AP biogenesis is carried out by a group of dedicated proteins (named ATG) and hinges on intense remodelling events and on the remarkable capacity of an initial membrane, the phagophore, to assemble de novo, shape like a cup, expand while maintaining structure and function and re-shape to a complete vesicle. To date the molecular mechanisms underlying these events remain elusive. Research has focused on the role of autophagy proteins but, despite AP biogenesis being a membrane-based process, the fundamental contributions of lipids to AP membrane formation, identity and activities have been largely unexplored; in other words, when it comes to AP formation we are only looking at half of the picture. I propose to address the fundamental question of how APs form and shape from a novel angle: by exploring how lipids’ nature, dynamics and lateral heterogeneity instruct the phagophore structure, its protein composition and its functions. The project builds on our recent results and expands on strategies that we have developed, integrating proteomic/bioinformatic approaches, lipidomics and high-resolution 3D imaging. We will tackle 3 complementary objectives: 1) Reveal the dynamic lipid signature of the phagophore, 2) Elucidate the implication of lipids nature and repartition in the phagophore ultrastructure, 3) Decrypt the molecular mechanisms by which lipids interplay with ATG proteins to control autophagy activity and plant physiology. Overall the project will articulate an integrated vision of the molecular processes controlling autophagy and provide fundamental knowledge in our understanding of plant adaptive programs.

Keywords: plant biology,plant adaptive responses
BOTTOM TRAWLING AS A DRIVER OF DEEP SEASCAPE TRANSFORMATION (TrawledSeas)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Malta
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2020-12-16
End date: 2022-12-15
Duration (months): 24.0
Total project cost (EUR): 160049.28
EU funding (EUR): 160049.28
Participants: 1
Project status: CLOSED

Bottom trawling is one of the most common fishing practices worldwide. It involves towing of nets along the seafloor to harvest benthic and demersal living resources for human consumption or industrial uses. The widespread and intensive use of these fishing activities on the continental margin has raised concerns in the European Union about the sustainability of this practice. The impacts of bottom trawling on the seafloor have been extensively investigated in shallow environments. However, very few studies have addressed the effect of continued trawling activities at depths beyond the shelf break. The main objective of TrawledSeas is to characterise the impact of bottom trawling, in terms of extent, rates and volume change, on the morphology of different geological and climatic deep (>200 m) seafloor settings. The project is based on an interdisciplinary approach that combines the quantitative analysis of high-resolution multibeam data with geophysical and sedimentological information, in situ observations and satellite-based vessel tracks. These data will be provided by leading research groups or derived from European and global databases of open geospatial data. A main component of the methodology consists of the development of a new automated marine landscape mapping technique to quantify the morphological signature of bottom trawling at fine and mesoscale, which will be conducted at the University of Malta and complemented at the Geological Survey of Norway. The collaborative nature of TrawledSeas will reinforce the researcher’s interdisciplinary background and international network. The project will also contribute to the researcher’s career development by providing technical skills on geomorphometry and research expertise on different geological settings, which will provide her with the high scientific profile necessary to develop innovative and integrative projects and to apply for national and European funding calls such as an ERC grant and Horizon 2020.

Keywords: bottom trawling,geomorphology,seascape
Photoreal REaltime Sentient ENTity (PRESENT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Italy,Spain,Belgium,France,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Interactive Technologies (H2020-ICT-2018-3, 2018)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 4102070.0
EU funding (EUR): 4102070.0
Participants: 12
Project status: CLOSED

PRESENT is a proposal for a three-year Research and Innovation project to create virtual digital companions––embodied agents––that look entirely naturalistic, demonstrate emotional sensitivity, can establish meaningful dialogue, add sense to the experience, and act as trustworthy guardians and guides in the interfaces for AR, VR and more traditional forms of media. There is no higher quality interaction than the human experience when we use all our senses together with language and cognition to understand our surroundings and––above all—to interact with other people. We interact with today’s ‘Intelligent Personal Assistants’ primarily by voice; communication is episodic, based on a request-response model. The user does not see the assistant, which does not take advantage of visual and emotional clues or evolve over time. However, advances in the real-time creation of photorealistic computer generated characters, coupled with emotion recognition and behaviour, and natural language technologies, allow us to envisage virtual agents that are realistic in both looks and behaviour; that can interact with users through vision, sound, touch and movement as they navigate rich and complex environments; converse in a natural manner; respond to moods and emotional states; and evolve in response to user behaviour. PRESENT will create and demonstrate a set of practical tools, a pipeline and APIs for creating realistic embodied agents and incorporating them in interfaces for a wide range of applications in entertainment, media and advertising. The international partnership includes the Oscar-winning VFX company Framestore; technology developers Brainstorm, Cubic Motion and IKinema; Europe’s largest certification authority InfoCert; research groups from Universitat Pompeu Fabra, Universität Augsburg and Inria; and the pioneers of immersive virtual reality performance CREW.

Keywords: sentient characters,photo realism,emotional facial and body animation,believable socially aware adaptive interactions,haptics,immersive virtual and augmented reality,trust,media and entertainment
Fostering public capacity to plan, finance and manage integrated urban REGeneration for sustainable energy uptake (FosterREG)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Spain,Spain,Croatia,Croatia,Poland,Netherlands,Netherlands
Call: Enhancing the capacity of public authorities to plan and implement sustainable energy policies and measures (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 1401921.0
EU funding (EUR): 1401921.0
Participants: 10
Project status: CLOSED

The lack of proper coordination of aspects related to regulation, financing and management of energy efficiency measures within urban regeneration initiatives, as well as the frequent misalignment of public stakeholders at different levels, are hindering the potential benefits of addressing these processes from an integrated perspective. FosterREG aims at enhancing public capacity at local, regional and national levels to plan, finance and manage integrated urban regeneration for sustainable energy uptake, through capacity building, promotion and articulation of effective multilevel coordination, and national as well as European network strengthening. These objectives will be achieved through public stakeholders’ engagement in joint analysis and knowledge development activities, as well as creation and dissemination of targeted training materials and activities across Europe. FosterREG relates to the Work Programme objectives by: 1) Focusing on the integration of energy efficiency measures within urban regeneration plans, with especial emphasis on building retrofitting while promoting synergies with other sectors such as transport and land-use planning. 2) Enhancing multilevel coordination (European, national, regional and local) of public authorities in the reduction of EU energy consumption. 3) Building capacity for civil servants at national, regional and local level in relation with policy design, planning, financing and management of energy efficiency measures within urban regeneration plans. 4) Fostering the implementation of the Energy Effciency Directive, in particular Articles 4 and 7.

Keywords: energy efficiency in urban regeneration
Energising Scientific Endeavour through Science Gateways and e-Infrastructures in Africa (Sci-GaIA)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Italy,South Africa,Sweden,Tanzania, United Republic of,France,Netherlands,Ghana,United Kingdom
Call: e-Infrastructure policy development and international cooperation (H2020-INFRASUPP-2014-2, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 1339125.0
EU funding (EUR): 1339125.0
Participants: 9
Project status: CLOSED

In African Communities of Practice (CoPs), international collaboration and the pursuit of scientific endeavour has faced a major barrier with the lack of access to e-Infrastructures and high performance network infrastructure enjoyed by European counterparts. With AfricaConnect, the proposed AfricaConnect2 and regional developments, this situation is changing rapidly. In the project Teaming-up for exploiting e-Infrastructures' potential to boost RTDI in Africa (eI4Africa) it has been demonstrated clearly that it is possible to develop e-Infrastructures in Africa. It has also been demonstrated clearly that, as with the rest of the world, easy to use web portals, or Science Gateways, are needed to help CoPs to easily access e-Infrastructure facilities and through these collaborate with CoPs across the world. However, a major problem exists: it is very difficult for non-experts to develop Science Gateways and supporting e-Infrastructures. Elements of guides and supporting materials exist but these are either written for different audiences or out of date. This present Coordination and Support Action, called Energising Scientific Endeavour through Science Gateways and e-Infrastructures in Africa (Sci-GaIA), therefore proposes to bring together these materials into clearly structured guides and educational documents that can be used to train and support representatives of NRENs, CoPs and, importantly, Universities to develop Science Gateways and other e-Infrastructures services in Africa. Sci-GaIA plans to work with new and emerging CoPs to develop these exciting technologies, to strengthen e-Infrastructure service provision, especially in terms of open access linked data, and to deliver training and dissemination workshops. This will give a sustainable foundation on which African e-Infrastructures can be developed and be linked to scientific networks across Africa. Importantly, the results of our project will be usable by CoPs in Europe and the rest of the world.

Keywords: e infrastructures,science gateways,africa,e science
THz Near-Field Imaging of Unconventional Superconductors (SUPERTERA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Superconducting materials are the heart of the modern quantum technologies including quantum computation with its main workhorse - superconducting qubits, magnetic flux and voltage quantum metrology with Josephson junctions and superconducting quantum interference devices. Hence the formidable effort to raise the superconducting transition temperature by researching new materials and superconductivity mechanisms beyond the standard Bardeen-Cooper-Schrieffer (BCS) model. On the other hand, the new superconductivity-based technologies emerge as the phenomenon is becoming more investigated and better understood. The coupling of THz frequency electromagnetic waves with superconducting matter and the emerging possibility of THz field generation, manipulation and detection via light-matter interactions in superconductors is the prime example . Superconductors present a wide playground for the future single-chip THz technology due to the rich electromagnetic response involving nonlinear processes. While the far-field THz nonlinearities in superconductors are being extensively studied for THz applications, the near-field nonlinear THz imaging would provide an insight to the superconducting excitations inaccessible in the linear regime and with high spatiotemporal resolution. In fact, the THz-frequency electromagnetic radiation represents a peculiar energy scale of important condensed matter excitations - interaction mediators in correlated electron systems (e.g. phonons for Cooper pairs in BCS superconductors), making them an indispensable probe for other electron - electron coupling mechanisms in unconventional correlated systems. This project is aimed at (i) implementation of a nonlinear spatiotemporal near-field imaging technique, and its application to the investigation of nanoscale-picosecond THz response of the two fascinating superconducting systems: (ii) high-Tc layered cuprates, (iii) the magic-angle twisted bilayer graphene.

Keywords: superconductivity,high tc superconducting cuprates,magic angle twisted bilayer graphene,thz radiation,josephson plasmon,higgs mode,scanning near field optical microscopy
The Precompetitive Steps of Virtual Transparency and Augmented Laparoscopy (P-ViTAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-05-01
End date: 2019-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Laparoscopy allows the surgeons to treat pathologies such as cancer with considerably less trauma for the patient than classical open surgery. The laparoscope is a small camera inserted in the patient’s abdominopelvic cavity. Laparoscopy has been used for decades but still suffers from the impossibility of seeing the organs’ inner anatomy. This forms an important limitation because it slows down surgery, prevents finding some tumors and dramatically limits the use of laparoscopy. ViTAL (Virtual Transparency and Augmented Laparoscopy) is a concept specifically developed by our group of scientists, surgeons and radiologists as a solution to the current hidden-anatomy limitation of laparoscopy. The ViTAL concept is to modify the laparoscope’s video in realtime to emulate organ transparency and to highlight features invisible to the naked eye. The proposed project P-ViTAL (Precompetitive steps for ViTAL) aims at developing a precompetitive software implementation of ViTAL. Technically, ViTAL exploits information extracted from routine radiological images such as Magnetic Resonance Images (MRI) acquired before surgery. Such a combination of visual information cannot be achieved mentally, even by experienced surgeons. Concretely, P-ViTAL has two objectives: 1) to develop a precompetitive prototype and 2) to create communication material. Objective 1) will be achieved by improving and extending the functional research prototype obtained in ERC project FLEXABLE. Two engineers will be hired to assist the team in this task. Objective 2) will be achieved by working with a communication agency. In particular, we aim at producing promotional brochures, images and video clips of laparoscopic surgery procedures achieved with ViTAL. P-ViTAL comes as the next important step towards our goal of creating a startup company. A feasibility analysis already confirmed that the market is open to the ViTAL technology and that it will be well-received.

Keywords: precompetitive,startup company,communication material,laparoscopic surgery,radiology,augmented reality,virtual transparency
New DELLA-based biotechnological tools for sustainable Agriculture (DELLATECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Since their discovery, the plant hormones gibberellins (GAs) and their inhibitors have become a widely used tool to improve very diverse agronomical aspects, such as the size and productivity of grasses, horticultural species and ornamental plants. However, indiscriminate application of these compounds also provokes undesired secondary effects. For instance, GA application is used in agriculture to promote and synchronize fruit development, but it weakens the defense mechanisms against pests. Therefore, there is a serious need to find new GA-related biotechnological tools that specifically improve certain agronomical traits without the lateral effects. Based on the deep knowledge generated about GA signaling in the past 20 years with the help of our own lab, here we propose to (1) establish a method to generate plant varieties that specifically improve certain GA-related traits without the lateral effects; (2) search for compounds that specifically mimic certain aspects of GA signaling; and (3) in conjunction with a Spanish biotech company, provide a well-trained academic scientist with the capacities needed to develop a professional career within industry-oriented biotechnological research.

Keywords: gibberellins,proof of concept,growth vs stress responses,chemical genetics
REFRESH - Relate, Experience, Find Research Everywhere and SHare (REFRESH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-06-01
End date: 2020-01-31
Duration (months): 20.0
Total project cost (EUR): 208125.0
EU funding (EUR): 208125.0
Participants: 21
Project status: CLOSED

REFRESH (Relate, Experience, Find Research Everywhere and SHare) is a 20-month project led by Centre for Research & Analysis with 20 partners and 27 associates. The Consortium includes 14 academic institutions, Bulgaria’s only tech park, a chamber of industry and commerce, the local office of a pan-European organisation, education entrepreneurships and a media outlet. The main ideas on which the proposal relies are coordinated, multi-city and international series events under a single, recognisable brand, with similar (familiar) formats but with fresh (and well communicated) content, led by central multidisciplinary themes in 2018 (European Year of Cultural Heritage) and sport (European Capital of Sport Sofia), and culture (European Capital of Culture Plovdiv 2019). Building on the Consortium’s existing understanding, developed through previous local initiatives including Researchers Night, and addressing findings of research (Special Eurobarometer 401, the MASIS report , the in-depth Education and Training Monitor 2017 for Bulgaria , the recently published Communication on Strengthening the European Identity through Education and Culture , REFRESH focusses on enhancing the public understanding of and engagement with science, encouraging children especially girls, to study STEM subjects. The participatory events will reach 3.6 mln, and engage 80,000 in least 14 cities/towns with live-streaming, face-to-face events at schools, libraries, museums, city venues and public transport, science talks and shows; hands-on experiments, lab visits and citizen science. The activities of the first year will allow learning to accrue from a thorough evaluation. The project will strengthen the capabilities of the partners in organising events for a general audience in open access format, and for underserved audiences, including girls and young people at risk of school drop-out, as well as young people with special needs.

Keywords: night,science,interdisciplinary,participatory,heritage,culture,communication,business,entrepreneurship,innovation,bulgaria,competitions,hands on science,awareness,evaluation,audience