Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Robustness, evolutionary optimality and plasticity of microbial signaling (MICROBE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Evolutionary, population and environmental biology
Countries involved: Germany,Germany
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2011-12-01
End date: 2016-11-30
Duration (months): 60.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 2
Project status: CLOSED

Most signaling and regulatory functions in the cell are executed by protein networks rather than by individual proteins, and it is therefore essential for biology to understand how the design and function of these networks have been shaped by the evolution. Despite differences in biological functions and molecular composition, all protein networks underlie similar evolutionary constrains on their performance and design, such as necessity to be robust against extra- and intracellular perturbations or to extract information from noisy environment. Moreover, although it can be assumed that a particular network has evolved to optimally solve certain problem, detailed quantitative analyses of optimality of the network performance are largely missing. Similarly little explored is the question of the network plasticity: how networks adapt to changing environmental conditions by adjustments of their structure and function, either regulating protein levels or undergoing microevolutionary changes. The goal of this proposal is to elucidate general features responsible for robustness and plasticity of cellular networks, using signaling networks in bacteria and yeast as well-tractable and relatively simple model systems. To achieve that, we will combine quantitative real-time analyses of the network function, primarily using high-throughput fluorescence microscopy, with computational modeling and with experimental microevolution, while exposing the networks to such common intra- and extracellular perturbations as variations in protein levels and in temperature. We expect our comparative analysis to provide general insights into the mechanisms of robustness and evolutionary optimization of cellular networks, thereby substantially advancing our understanding of biological systems.

Keywords: experimental microevolution optimality analysis robustness analysis protein network dynamics
Switchable in vivo genetic models to identify cancer drug targets (ONCOSWITCH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: United Kingdom
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-04-01
End date: 2017-03-31
Duration (months): 60.0
Total project cost (EUR): 2483235.6
EU funding (EUR): 2483235.6
Participants: 1
Project status: CLOSED

The use of classical, germ-line genetics to define gene function in vertebrates is severely limited by embryonic lethality, developmental compensation and adaptive functional degeneracy, all of which obscure the roles played by genes in adult tissues that would normally have developed in the presence of that gene. Consequently, classical germ line knock-out technologies provide only limited information as to the roles of genes in adult tissues and their pathologies. Nowhere is this limitation more profound than in our understanding of cancers, diseases that arise in the main through genetic accidents in established adult tissues and in which defining the ongoing roles of specific genes in maintenance of established tumours is crucial for identifying targets for therapeutic intervention. We will develop a suite of novel technologies for “kinetic genetics” – the rapid and reversible inhibition of specific genes in adult mice, either systemically or in specific tissues. These technologies will not only provide invaluable and novel information concerning gene function in adult tissues but we will use them specifically to define which components of oncogenic networks make the best targets for future cancer therapy.

Keywords: cancer,identifying drug targets,mouse models,switchable genetics
Customised Advisory Services for Energy-efficient Manufacturing Systems (CASES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Spain,United Kingdom,France
Call:  (FP7-PEOPLE-2011-IRSES, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 379400.0
EU funding (EUR): 379400.0
Participants: 4
Project status: CLOSED

This CASES project is aimed at teaming up trans-continental researchers in the areas of sustainable design/manufacturing and ICT to enrich the knowledge base and achieve research synergies to develop smart design and manufacturing planning services in terms of energy efficiency. The objectives include: (1) To establish an active international community and effective communication channel for research teams from various regions of the EU, China and Ukraine to collaborate in the research area of eco-design and energy-efficient manufacturing planning. (2) To integrate the complementary expertise of the European, Chinese and Ukrainian teams to devise ICT-based smart services and standards to address the multi-faceted requirements of eco-design and sustainable manufacturing planning. Activities include: • The impact of globally sustainable trends on the current practices in the EU, China and Ukraine would be evaluated and relevant strategies and best practices will be proposed; • Research in eco-design, manufacturing planning, cloud and service-oriented computing, and computational intelligence will be synchronised to develop innovative smart services. (3) To leverage the geographical characteristics of all teams for research evaluation, improvement and dissemination. The plan includes: • The smart services, acquired from the integration of research, systems and algorithms within the teams, will be deployed geographically dispersed for evaluation and improvement; • Knowledge sharing and outreach activities will be organised for relevant communities and stakeholders in the EU, China and Ukraine to increase the awareness of the proposed solutions to enable them to shift towards sustainability efficiently.

Keywords: energy-efficient manufacturing systems,ict smart services,eco-design,manufacturing system simulation and optimisation,technological sciences
Development of sustainable electrochemical corrosion protection systems for reinforced concrete structures (DOSECOPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Sweden,Italy
Call:  (FP7-PEOPLE-2011-IRSES, 2011)
Start date: 2012-07-01
End date: 2016-06-30
Duration (months): 48.0
Total project cost (EUR): 327600.0
EU funding (EUR): 327600.0
Participants: 3
Project status: CLOSED

Corrosion of reinforcing steel in concrete structures is a worldwide problem and affects a large number of infrastructures. Two major causes connected to corrosion of reinforcing steel are the carbonation and chloride attack. Concrete carbonation produces a carbonated surface layer in which the pore solution pH value is depressed to near-neutral levels. A fall in pH to values below 10 at the steel can render the steel passive film thermodynamically unstable and thus cause steel corrosion. While chloride attack causes localised breakdown of the passive film that initially forms on steel as a result of the alkaline nature of the pore solution in concrete. The harmful chloride ions can be originated from the use of contaminated mix constituents or from the surrounding environment such as deicing salts or seawater. The corrosion of steel not only reduces the strength of reinforcement but also can lead to cracking and spalling of cover concrete because of the substantial volume increase that accompanies the transformation of iron to rust. To promote the effective application of reinforced concrete it is important to protect the reinforcing steel from corrosion during its service life. This proposal is to explore a new electrochemical remediation of reinforced concrete structures by combining conventional electrochemical processes, such as the electrochemical chloride removal for chloride contaminated concrete and the electrochemical realkalisation for carbonated concrete, with electrochemical nanoparticle injection. Using the new electrochemical processes, not only can they remove chlorides from concrete and increase alkalinity in concrete pore solution but also simultaneously inject nanoparticles into the concrete to enhance its mechanical properties as well as improve its porosity to stop the further penetration of chlorides and CO2 from its surrounding environment, and thus provide a permanent solution for concrete repair suffered from carbonation and chloride attack.

Keywords: reinforced concrete,infrastructure,electrochemical,corrosion,nano-particles,materials,structures,experiments,computer modelling.
Jordan Conservation of Cultural Heritage in ERA (JOCHERA)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Jordan,Italy,Türkiye,Spain,Italy
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2011-12-01
End date: 2013-11-30
Duration (months): 24.0
Total project cost (EUR): 597797.0
EU funding (EUR): 499614.0
Participants: 5
Project status: CLOSED

The Jordan Conservation of Cultural Heritage in ERA – JOCHERA project is aiming at overall reinforcement of University of Jordan, Hamdi Mango Center for Scientific Research (HMCSR) in Jordan cooperation capacities for cultural heritage protection research in the context of the European Research Area and development to the Conservation centre of excellence to respond to Jordan’s socio-economic needs. Corresponding with EU challenges for international S&T cooperation and integration in ERA, as well specific development needs of UJ and particular Jordan’s demands in cultural heritage protection sector, in particular 1) UJ’s cooperation capacities reinforcement through targeted trainings for research management, IPR issues and FP7 projects writing and management; 2) cultural heritage stakeholders involvement in the future strategy formulation; 3) UJ strengthening for internationalization and improved coordination between research and business stakeholders; 4) Enhancement of EU-JO S&T partnerships in cultural heritage protection research and related research results dissemination to Jordanian and European audiences; 5)Jordan young researchers support in fields of cultural heritage protection research. The JOCHERA impact will be increased capacities of the UJ in terms of (i) better research and innovation management, (ii) improved international S&T cooperation and participation in FP7, (iii) enhanced cultural heritage protection research capacities, and (v) defined strategic development framework in order to increase UJ visibility and scope. Likewise, JOCHERA will increase research and innovation linkages within Jordan in particular with SMEs, enable better opportunities to young researchers and enhance EU-JO RTD cooperation landscape. The JOCHERA consortium brings together 5 Jordanian and EU organisations representing a well-defined mix of expertise for strategic development, innovation management and technological foresight. The project duration is 24 months.

Keywords: cultural heritage,nanotechnolgy
Lebanon-Europe "on boarding" to innovate and enhance research links in health (LEB'IN)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Lebanon,France,France
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2012-03-01
End date: 2014-08-31
Duration (months): 30.0
Total project cost (EUR): 612178.8
EU funding (EUR): 510082.0
Participants: 4
Project status: CLOSED

The 30-month LEB’IN project gives Lebanon the possibility to improve the research activities of their highest quality in the FP7 thematic priority “Health”, through twinning activities between one of the leading Lebanon scientific and educational organisations Saint-Joseph University, with their long term partner the Aix-Marseille University , located in Marseille (France). The S&T specialist (inno), an international S&T collaboration expert and experienced FP7 coach and trainer for the scientific organisations, will provide methodological, coaching and training support to the project. Berytech,a Lebanese business incubator, will provide input for alaytical work and health workshops. A coherent development strategy for USJ will be prepared, based on SWOT analysis and on the socio-economic analysis on a Lebanese, regional (Mediterranean) and European level. A joint research plan will be then agreed by the twinned partners and a plan for strengthening of collaboration research links between USJ and other EU research organisations will be set up and implemented. The objective of this proposal is to establish a framework of cooperation between USJ in Lebanon and AMU in France under the umbrella of FP7, INCO- ERA and to offer the USJ students, faculty members of this university and other educational institutions in neighbouring countries the possibility to perform research in adequate levels of HEALTH. This project aims to strengthen cooperation and research capacities of Lebanon prominent research centre, USJ, bringing them at the highest level. It will also include several main types of activities, thus forming a coherent plan for improving the USJ’ capacities in a number of fields relevant to the FP7 Thematic Priority “HEALTH”: • Twinning activities • Large-scale networking & brokerage activities • Exchange of researchers and young specialists and organisation of joint events such as summer school and an international conference • Training and coaching activit

Keywords: lebanon-europe,health,medical research,mediterranean university of aix-marseille ii,saint joseph university,twinning concept,cooperation and research
Boosting EU-Ukraine cooperation in the field of Superhard Materials (START)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Ukraine,France,Poland,Greece
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2011-11-01
End date: 2014-07-31
Duration (months): 33.0
Total project cost (EUR): 554370.4
EU funding (EUR): 499945.0
Participants: 4
Project status: CLOSED

The vision of START is to reinforce the cooperation between EU and Ukraine in the field of Superhard Materials and its application areas in the various thematic priorities of FP7. Thus, START will support the Ukraine’s leading research institute in the field of Superhard Materials, namely V.N. Bakul Institute for Superhard Materials of the National Academy of Sciences of Ukraine (ISM), to become a “flagship institute’ in international cooperation. START will: a) analyse ISM’s research competencies, review the scientific and technological developments and examine the EU/Ukraine’s collaboration framework in order to develop ISM’s long-term Research Strategy and position the Institute in the international research arena; b) set up a consultation, assessment and validation mechanism in a collaborative perspective with EU research actors to monitor the implementation on ISM’s Research Strategy; c) organise a variety of training activities adjusted to the Institute’s support needs building ISM’s competencies towards its participation in future FP7 collaborative research activities; d) deploy a set of diversified twinning activities, to significantly increase ISM’s networking level facilitate the exchange of knowledge and good practices and, thus, prepare the ground for setting Joint Research Plans with EU leading research centres; e) support the implementation of joint research activities between ISM and leading EU research centres in the field of Superhard Materials; and f) facilitate the exchange of research staff between ISM and EU research centres, enabling them to carry out joint experiments and, thus, setting the foundations for long-term collaboration. START will be coordinated by ISM, which is the targeted leading research institute of Ukraine in the field of Superhard Materials, and mobilise a multi-disciplinary consortium of 4 partners (1 from Ukraine and 3 from EU countries), while its duration will be 30 months.

Keywords: superhard materials,eu-ukraine research cooperation,twinning activities,fp7 training activities
Supporting the Establishment of a Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training (KHCCBIO)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Jordan,Ireland,Switzerland,Ireland
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2011-11-15
End date: 2014-05-14
Duration (months): 30.0
Total project cost (EUR): 616646.4
EU funding (EUR): 549843.04
Participants: 4
Project status: CLOSED

The King Hussein Cancer Center (KHCC) in Jordan, a highly accredited hospital, treats over 3,500 new adult and paediatric cancer patients annually from Jordan and its neighbouring countries. KHCC wishes to maintain its pioneering position in cancer detection and treatment and plans to establish a state-of-the-art biospecimen repository to store and archive tissue samples for use in cancer research with the support and experience of experts in biobanking and quality management from Trinity College Dublin and two European SMEs. The KHCCBIO bank will collect, process, extract, store high-quality, clinically annotated biospecimens from consented patients and distribute them to researchers worldwide. It will be established using current international guidelines, best practices and will incorporate the highest level of Quality Management System (QMS) based on ISO standards & the EU’s Tissue & Cells Directives. European partners will deliver training and support to KHCC and provide a proven solution, based on existing licensed technology & know-how. Instruction and training will be given in FP7 project management, implementation of Quality Management Systems, genetics of thoracic cancer, creation of a Europe-wide lung cancer biobank (EUELC), standard operating procedures for the procurement, processing, storage and distribution of human tissues & cells, expert guidance in ethics, data protection & confidentiality, computer systems implementation & validation and an introduction to an international network of oncology specialists to interact with and share knowledge with. Today, the vast majority of the millions of biospecimens in collections around the world are not suitable for making the type of direct comparisons that modern cancer biology research demands. The KHCCBIO bank will help change all that and provide a bank of biospecimens, from a diverse ethnic Middle Eastern population that will be a valuable resource in our arsenal and the battle against cancer.

Keywords: biobanking,tissue,repository,thoracic,lung,cancer,oncology,iso9000,biospecimens,middle east,jordan
The National Centre for Research and Development (NCRD) as a Centre of Excellence for EU-Jordan S&T Cooperation: Towards Jordan's Integration into ERA (J-ERACENTER)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Reinforcing cooperation with Europe's neighbours in the context of the ERA
Action type: Coordination and support actions
Countries involved: Spain,Austria,Spain,Jordan
Call:  (FP7-INCO-2011-6, 2011)
Start date: 2012-08-01
End date: 2014-10-31
Duration (months): 27.0
Total project cost (EUR): 548004.0
EU funding (EUR): 488636.9
Participants: 5
Project status: CLOSED

The overarching aim of the J-ERAcenter is: To contribute to the effective integration of Jordan into ERA, through building the National Centre for Research and Development (NCRD) organisational, strategic and human capacities to actively participate in European S&T partnerships and execute large-scale projects in the key area of Renewable Energy, with a view to creating a centre of excellence within Jordan and actively promoting further dissemination and replication in the region. Specifically J-ERAcenter aims: • To build capacities in international R&D cooperation and EU project management, by providing targeted training to NCRD staff and researchers and enable them to replicate the knowledge benefiting a wider target group of researchers in Jordan. • To strengthen direct links between research teams of NCRD and their EU counterparts and initiate joint R&D initiatives in the area of Renewable Energy, through a series of networking/partnering events and facilitating mobility of researchers. • To ensure firm and sustainable implementation of the enhanced capacities at NCRD with a view to promoting the centre’s international competitiveness and improve its response to socio-economic challenges; through implementing specific internationalisation, visibility, IP and competitiveness strategies (for enhancement of the institutional development strategy), and the implementation of a R&D Cooperation Unit. • To promote the visibility and impact of this pilot action, positioning NCRD as a Centre of Excellence for EU-Jordan RTD cooperation, via targeted multiplication and dissemination actions (networking events, info-days, seminars). Jordan’s leading research centre in Renewable Energy is the main beneficiary and coordinator, due to its high multiplier potential to act as catalyst for integration into ERA, and the importance of RE to both regions. The consortium includes EU partners with complementary expertise in the scientific field (UASTV, UMU) and EU project management (UA).

Keywords: mediterranean region,photovoltaics,renewable energy sources,research policy,research management,r&d cooperation,project management,networking,internationalisation.