Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Experimentation and Validation Openness for Long-term evolution of VErtical inDustries in 5G era and beyond (EVOLVED-5G)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: 5G PPP (cPPP)
Countries involved: Spain,Spain,Germany,Spain,Italy,Spain,Estonia,Cyprus,Greece,Greece,Greece,Romania,Slovenia,France,France,Luxembourg,United Kingdom,United Kingdom
Call: 5G PPP – 5G innovations for verticals with third party services (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 7988187.5
EU funding (EUR): 5999993.75
Participants: 26
Project status: SIGNED

The intense ongoing work towards 5G readiness has reached the point where the performance gains provided by 5G infrastructures should be exploited by third party innovators and SMEs, to create a new, open and dynamic ecosystem from both technology and marketing perspectives. Towards the materialization of the 5G performance gains at application and market level, key contributions are expected by the domain of design and development of Network Application (NetApp). In this context, EVOLVED-5G endorses the vision where the world of NetApps follows the paradigm of mobile applications hosted in a related market place. Moreover, the EVOLVED-5G project will contribute towards the fourth industrial revolution or Industry 4.0. Recognized as one of the major vertical industries by 5G-PPP (referring to the digital evolving of workspaces), Industry 4.0 brings innovative use cases, yet technologically challenging, and create a fertile environment for SME-driven entrepreneurship, where new use case-tailored functions (as NetApps) can be provided to compose a digitalized, secure, and automated generation of the industrial operations (mainly referring to functions for process and machine control as well as procedures for advanced product lifecycle management). The industry-oriented EVOLVED-5G NetApps will be tested, validated, and certified in a vendor-agnostic experimentation platform, and progressively define the first set of NetApps that the EVOLVED-5G marketplace will host.

Keywords: industry 4 0,netapp,network programmability,multi domain orchestration,capif,seal,marketplace
3D Bioprinting of JOINT Replacements (3D-JOINT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-06-30
Duration (months): 60.0
Total project cost (EUR): 1998871.0
EU funding (EUR): 1901871.0
Participants: 2
Project status: CLOSED

The world has a significant medical challenge in repairing injured or diseased joints. Joint degeneration and its related pain is a major socio-economic burden that will increase over the next decade and is currently addressed by implanting a metal prosthesis. For the long term, the ideal solution to joint injury is to successfully regenerate rather than replace the damaged cartilage with synthetic implants. Recent advances in key technologies are now bringing this “holy grail” within reach; regenerative approaches, based on cell therapy, are already clinically available albeit only for smaller focal cartilage defects. One of these key technologies is three-dimensional (3D) bio-printing, which provides a greatly controlled placement and organization of living constructs through the layer-by-layer deposition of materials and cells. These tissue constructs can be applied as tissue models for research and screening. However, the lack of biomechanical properties of these tissue constructs has hampered their application to the regeneration of damaged, degenerated or diseased tissue. Having established a cartilage-focussed research laboratory in the University Medical Center Utrecht, I have addressed this biomechanical limitation of hydrogels through the use of hydrogel composites. Specifically, I have pioneered a 3D bio-printing technology that combines accurately printed small diameter thermoplast filaments with cell invasive hydrogels to form strong fibre-reinforced constructs. This, in combination with bioreactor technology, is the key to the generation of larger, complex tissue constructs with cartilage-like biomechanical resilience. With 3D-JOINT I will use my in-depth bio-printing and bioreactor knowledge and experience to develop a multi-phasic 3D-printed biological replacement of the joint.

Keywords: 3d printing,biofabrication,cartilage,hydrogel
Integrating spatial and genetic information via automated image analysis and interactive visualization of tissue data (TissueMaps)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-04-01
End date: 2022-03-31
Duration (months): 72.0
Total project cost (EUR): 1738690.0
EU funding (EUR): 1738690.0
Participants: 1
Project status: CLOSED

Digital imaging of tissue samples and genetic analysis by next generation sequencing are two rapidly emerging fields in pathology. The exponential growth in digital imaging in pathology is catalyzed by more advanced imaging hardware, comparable to the complete shift from analog to digital images that took place in radiology a couple of decades ago: Entire glass slides can be digitized at near the optical resolution limits in only a few minutes’ time, and fluorescence as well as bright field stains can be imaged in parallel. Genetic analysis, and particularly transcriptomics, is rapidly evolving thanks to the impressive development of next generation sequencing technologies, enabling genome-wide single-cell analysis of DNA and RNA in thousands of cells at constantly decreasing costs. However, most of today’s available technologies result in a genetic analysis that is decoupled from the morphological and spatial information of the original tissue sample, while many important questions in tumor- and developmental biology require single cell spatial resolution to understand tissue heterogeneity. The goal of the proposed project is to develop computational methods that bridge these two emerging fields. We want to combine spatially resolved high-throughput genomics analysis of tissue sections with digital image analysis of tissue morphology. Together with collaborators from the biomedical field, we propose two approaches for spatially resolved genomics; one based on sequencing mRNA transcripts directly in tissue samples, and one based on spatially resolved cellular barcoding followed by single cell sequencing. Both approaches require development of advanced digital image processing methods. Thus, we will couple genetic analysis with digital pathology. Going beyond visual assessment of this rich digital data will be a fundamental component for the future development of histopathology, both as a diagnostic tool and as a research field.

Keywords: digital image analysis,digital pathology,tissue analysis,visualisation
Controlling Triplet Excitons in Organic Semiconductors (CONTREX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2019-07-31
Duration (months): 40.0
Total project cost (EUR): 1025999.26
EU funding (EUR): 789041.13
Participants: 2
Project status: CLOSED

The urgent need to reduce carbon emissions in order to mitigate climate change requires the development of clean, renewable energy sources. Solar power offers a virtually unlimited supply of energy, providing it can be harnessed efficiently. Traditional silicon solar cells demonstrate high performance (~20%) but their required method of manufacture prohibits large area production rendering them too expensive to be used on a global scale. Organic solar cells (made from conjugated polymers and fullerenes) have the potential to be fabricated by low cost printing methods allowing for large scale modules to be produced cheaply. Conventional organic solar cells function by generating charge from a singlet excited state. In order to achieve optimum performance the precise morphology of polymer and fullerene must be controlled which can be extremely challenging. These devices however, have attained good efficiencies (10%) but are hampered by severe loss mechanisms which generally involve the formation of a lower energy triplet excited state. We propose to develop novel materials for organic solar cells which will instead utilise this triplet excited state to generate charges. This will enable us to not only eliminate this loss mechanism but due to the unique properties of the triplet excited state will allow for numerous benefits. Firstly, the long lifetime of the triplet excited state will be exploited to allow for a simpler organic solar cell where precise morphological control is not required. Secondly, the proposed new materials will allow for the utilisation of near-IR light which is typically wasted in ALL current solar cell devices. Thirdly, exploiting a unique photophysical process we will produce materials capable of delivering efficiencies in excess of the theoretical limit available to conventional solar cells. Thus we propose that utilisation of triplet excitons is the required step-change to allow for organic solar cells to achieve their ultimate efficiencies

Keywords: conjugated polymers,organic solar cells
Deep Investigation on Molecular Processes At early Cosmic Times (DeepIMPACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

The discovery of galaxies formed when the Universe was less than 1 Gyr old has been a major breakthrough of extragalactic astronomy. During this period, called Epoch of Reionization (EoR), the Universe experienced a dramatic change: from being a dark “sea” of neutral hydrogen and helium, it got completely reionized and polluted with elements heavier than helium. Thus, characterizing the bulk of galaxy population at these early epochs is pivotal because of their strong impact on the cosmic evolution. The most distant galaxies have been detected searching for their Lyman-α emission (Lyman Alpha Emitters; LAEs), and/or for the “step”, introduced by the blanketing effect of neutral hydrogen into their UV continuum emission (Lyman Break Galaxies; LBGs). LAEs/LBGs are quite “normal” objects, therefore they are thought to be fairly representative of the bulk of galaxies at the end of the EoR. Our knowledge about these sources regards their stellar component (star formation rates, stellar age and mass). However, we have few clues about their interstellar medium, the properties of the giant molecular clouds (GMCs) where stars form, and, most importantly, the possible presence of faint Active Galactic Nuclei (AGN). So far only extremely luminous ones, produced by gas accretion onto supermassive black holes whose formation is puzzling, have been detected during the EoR. I propose to model chemical, physical, and radiative processes in GMCs illuminated by both young stars and AGN. The aim is to quantify: (i) the impact of far-ultraviolet and X- ray photons on the clumpy structure of GMCs, (ii) the resulting time evolution of the line luminosities from GMCs (iii) whether the AGN signature can be observed in the molecular emission and (iv) which are the best LAE/LBG candidates (in term of star formation rate and age of stellar population) for observational follow up targeting the molecular gas.

Keywords: molecular clouds,x ray dominated regions,first galaxies
Enabling precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices (CHEM2NATURE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Switzerland,Korea, Republic of,United Kingdom,Portugal,Portugal
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1007453.75
EU funding (EUR): 1007453.75
Participants: 5
Project status: CLOSED

CHEM2NATURE addresses current limitations of UMINHO in the Chemistry field regarding its scientific know-how and partnerships with world-leading institutions. UMINHO seeks to improve the multifunctionality of natural-origin polymers, often with limited bioactivity and stimuli-responsiveness, and increase the performance of cell-based therapies. Introducing such properties by precision chemical modifications would allow the development of added-value products with instructive and adaptive properties for cellular response control, drug delivery and diagnosis. The main goal of CHEM2NATURE is to combat UMINHO’s limited knowledge, expertise and experience on advanced chemical routes for biopolymer, biomaterials and “living” surface modification. To this aim, an international training and scientific network will be established to accelerate the generation of technologies amenable to be used in the production of innovative healthcare devices. The capability of UMINHO to train highly-qualified researchers and staff would greatly increase, giving rise to a new generation of specialized professionals with scientific/translational competence. The consortium will comprise UMINHO, UAVR and 3 international competitive institutions in Chemistry: 2 European and 1 Asian. The latter will improve UMINHO’s know-how in the translational/clinical fields and raise opportunities to establish new contacts with high-performing and Emerging Asian countries. CHEM2NATURE proposes the joint organisation of events and short-term exchange of senior researchers and staff, aiming at training actions and execution of scientific work in the scope of ongoing scientific projects. Outputs include the increase of number and quality of scientific publications, intellectual property and regional-to-national economic development. CHEM2NATURE will endorse the establishment of a long-lasting consortium beyond the project timeframe for the preparation of new scientific projects and research lines in UMINHO.

Keywords: precision chemistry,natural origin materials,adaptive materials,multifunctional biomedical devices,biomedical engineering,researchers training,output increase,strong long lasting consortium
Electricity driven Low Energy and Chemical input Technology foR Accelerated bioremediation (ELECTRA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Germany,Germany,Spain,Belgium,Greece,Hungary,China,Switzerland,Switzerland,Switzerland
Call: New biotechnologies for environmental remediation (RIA) (H2020-NMBP-BIO-CN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 7301140.18
EU funding (EUR): 4995056.25
Participants: 23
Project status: CLOSED

The ELECTRA project is a EU-China RTD joint initiative that will deliver 2 innovative sets of novel electromicrobiology based environmental biotechnologies, facilitating/improving electron transfer during microbial degradation processes. Our approach will accelerate the elimination of several classes of pollutants and mixtures thereof in contaminated wastewater, groundwater, sediment and soil. The first set of biotechnologies employs bioelectrochemical systems requiring low energy input and no chemical addition. The second set comprises biotechnologies, which necessitate no energy input and minimal chemical amendment using electromicrobial concepts. ELECTRA biotechnologies will build on recent groundbreaking advances in biotechnology to develop them for environmental bioremediation applications and test the 4 most advanced technologies during field trials under various environmentally relevant conditions in both Europe (4 sites with contaminated wastewater, groundwater, soil, and sediment) and China (4 sites: mirroring tests concept) to prove their efficiency and robustness. The ELECTRA project deliberately addresses the accelerated elimination of compounds representative of hydrocarbons and derivatives, emerging pollutants, metals and nutrients and mixtures thereof in environmentally relevant concentration as a wise and careful approach taking into account the real problem of contaminations by organic and inorganic pollutants as well as nutrients. ELECTRA is a consortium of European and Chinese partners for a 4-year project. The EC-funded consortium gathers 17 partners from 6 EU countries,1 Associated Country. 1 large Chinese company is part of the EC consortium without claiming any funding from the EC since NSFC finances only fundamental research and does not allow for the inclusion of companies as partners in NSFC projects. This company has a key/essential role in replicating field test experiments from European sites to Chinese sites. The NSFC-funded consortium is constituted by five research institutions acting as international partners.

Keywords: bio electro chemical systems,3 d printed biofilms,nanoparticles,microbial consortia,china,field experiments
Frontiers in invasive species distribution modelling: incorporating human-associations and intraspecific niche structure to improve risk predictions. (InvasiveSDM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-15
End date: 2019-07-14
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Biological invasions represent a major component of global change through their impacts on biodiversity, ecosystems and societies. Awareness of biological invasion impacts and the critical importance of evidence-based decision making have led to a persistent effort to understand the factors driving invasion success so as to be able to predict invasion outcomes. To this end, a range of modelling tools has been developed. Among them, species distribution models (SDMs) -phenomenological models that statistically relate observed species occurrences to environmental variables- play a critical role in invasion risk assessments. These models rely on ecological niche theory, which predicts that for recent events such as biological invasions, conservatism of the climatic niche is expected. However, recent studies have demonstrated that this approach could be hampered by apparent niche shifts in invasive ranges. Mismatches between native and invasive distributions derived from SDMs have been often interpreted as species adaptations in response to selection pressures in novel environments. However, methodological drawbacks of previous approaches fuel doubts about the biological meaning of these findings. In this project, two unresolved challenges faced by SDMs when applied to the biological invasion process will be examined: how (1) species’ association with human-modified habitats in native ranges and (2) intraspecific niche variation shape the distribution of invasive species at biogeographical scales and how these effects influence the reliability of predictions of invasion risk. To accomplish these goals, I will use an interdisciplinary approach combining global bird distribution data, with molecular phylogenetic data and modern statistical and ecological analyses. The results of the project will contribute to improve prediction accuracy of biological invasions, and will also help better understand the invasion process.

Keywords: biological invasions,human associations,intraspecific variation,phylogeographic niche structure,species distribution models
Chromatin Dynamics in Development and Disease (Chromatin3D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Israel,Italy,Spain,Italy,Germany,Germany,Sweden,Greece,Belgium,Hungary,Greece,Netherlands,United Kingdom,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3782583.36
EU funding (EUR): 3782583.3600000003
Participants: 17
Project status: CLOSED

The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the chromatin structure are implicated in pathologies such as cancer. Higher order organization of chromatin results in chromosomes which occupy discrete territories within the cell nucleus. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging question is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. The dynamic assembly and modification of chromatin during developmental processes as well as the deregulation of such chromatin dynamics during the onset of disease lacks mechanistic insights at present. To address these questions we have put forward a multidisciplinary approach which involves molecular, cellular and systems level approaches by assembling a group of scientists from academia and industry with cross disciplinary expertise and capabilities.

Keywords: chromatin organization,cell nuclear structure,epigenetics,cancer,epigenetic regulation of developmental processes,genomics,proteomics,transcriptomics,chromosome conformation structure