Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of miR-129-5p and Rbfox1 crosstalk in neural network homeostasis (Neuronetmir)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

Imbalances between excitatory and inhibitory neural networks are a hallmark of several brain disorders including epilepsy. Current drug therapies for epilepsy are ineffective in a third of patients and none have disease-modifying effects. It is of high priority, therefore, to understand molecular/ genetic mechanisms responsible for epilepsy development and identify novel targets. The control of mRNA stability and translation is critical for proper neural network function. Here, RNA binding proteins (RBPs) and small noncoding RNAs called microRNAs (miRNA) act together to fine-tune levels of proteins critical for synaptic structure and function. These may represent important therapeutic targets since they regulate gene networks and exert broader actions that can generate more potent effects against seizures. Until now there has been no systematic analysis of miRNA, RBP crosstalk in the context of neural network stability in epilepsy. Building on my recent breakthrough studies showing miR-129-5p/Rbfox1 crosstalk in neural network homeostasis my project will explore the following objectives: First, identify targets regulated by miR-129-5p/Rbfox1 crosstalk in vivo; Second, functionally interrogate miR-129-5p/Rbfox1 crosstalk in neural network stability in vitro and in vivo; Third, investigate miR-129-5p and Rbfox1 function in human neural networks. To achieve these objectives I will apply my existing expertise as well as acquire new skills in a range of state-of-the-art interdisciplinary and cutting-edge techniques including single molecule imaging, proteomic analyses, multiple electrode arrays, human brain organotypic cultures and pre-clinical animal models. The results will establish RBPs, alongside miRNAs, as new mediators of epileptogenic network pathogenesis. Findings will also generate new targets for pre-clinical development and evidence of efficacy in human cells for disease-modifying therapies for epilepsy and disorders of neural network homeostasis.

Keywords: post transcriptional regulation,epilepsy,human neural networks
Stratification of Obesity Phenotypes to Optimize Future Therapy (SOPHIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Ireland,Germany,Germany,Spain,Ireland,Italy,Italy,Germany,Israel,Spain,Spain,Germany,Germany,Belgium,Sweden,Sweden,Switzerland,Switzerland,Belgium,France,France,United States,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom,United Kingdom,Kuwait
Call: Optimising future obesity treatment (H2020-JTI-IMI2-2019-17-two-stage, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 16668390.75
EU funding (EUR): 8301000.0
Participants: 39
Project status: SIGNED

SOPHIA will optimise the future treatment of obesity. The challenge is that clinicians, payers and patients view obesity as a failure of self-control, rather than a disease. We will change this perspective by defining subpopulations in terms of (a) the risks of complications linked to obesity, (b) response to various obesity treatments. The subpopulations will be characterised in terms of operational variables (phenotypic, genetic, behavioural, environmental, and omics). These predictive variables will facilitate diagnosis and underpin personalised and protocolised obesity care. Patient priorities regarding risk and response will influence all aspects of our work. SOPHIA will create a federated database of premier EU cohorts to identify operational variables that are predictive of risk and treatment response in people with and without diabetes. We will validate the predictive value of these variables before creating clinically-useful algorithms to decide “when-to-treat” and “how-to-treat”. Biomarker variables will feed into innovative assays, tests and research targets. We will interpret and analyse our results, to identify shared value across all stakeholders (patients, clinicians, industry, payers). SOPHIA will change attitudes and experience of obesity by (1) demonstrating the heterogeneity of the disease, (2) identifying people at risk of complications, (3) identifying the best treatment for each individual, (4) delivering a common vocabulary and shared understanding of obesity, (5) demonstrating shared value, which combines commercial opportunity with societal benefit. Our ambition will only be realised if (a) payers agree to fund treatment, (b) industry generate effective treatments, (c) clinicians are prepared to prescribe treatments, and (d) patients are prepared to take treatments. The evidence base does not currently exist. SOPHIA will deliver this evidence and the shared value analysis to drive this revolution in obesity care.

Keywords: obesity,predictors of risk,predictors of response,when to treat algorithm,how to treat algorithm,federated databases,shared value analysis,patient voice,people living with obesity
SAFety and secURity by design for interconnected mixed-critical cyber-physical systems (SAFURE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Spain,Austria,Germany,Germany,Austria,Switzerland,France
Call: Smart Cyber-Physical Systems (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-05-31
Duration (months): 40.0
Total project cost (EUR): 5702631.25
EU funding (EUR): 5231375.0
Participants: 12
Project status: CLOSED

SAFURE targets the design of cyber-physical systems by implementing a methodology that ensures safety and security "by construction". This methodology is enabled by a framework developed to extend system capabilities so as to control the concurrent effects of security threats on the system behaviour. The current approach for security on safety-critical embedded systems is generally to keep subsystems separated, but this approach is now being challenged by technological evolution towards openness, increased communications and use of multi-core architectures. The objectives of SAFURE are to (1) implement a holistic approach to safety and security of embedded dependable systems, preventing and detecting potential attacks; (2) to empower designers and developers with analysis methods, development tools and execution capabilities that jointly consider security and safety; (3) to set the ground for the development of SAFURE-compliant mixed-critical embedded products. The results of SAFURE will be (1) a framework with the capability to detect, prevent and protect from security threats on safety, able to monitor from application level down to the hardware level potential attacks to system integrity from time, energy, temperature and data threats; (2) a methodology that supports the joint design of safety and security of embedded systems, assisting the designer and developers with tools and modelling languages extensions; (3) proof-of concept through 3 industrial use cases in automotive and telecommunications; (4) recommendations for extensions of standards to integrate security on safety-critical systems; (5) specifications to design and develop SAFURE-compliant products. The impact of SAFURE will help European suppliers of safety-critical embedded products to develop more cost and energy-aware solutions. To ensure this impact, a community will be created around the project. SAFURE comprises 7 industrial manufacturers, 4 leading universities and research centres and 1 SME.

Keywords: safety,security,safety critical,mixed criticality,dependable systems,methodology,framework
How prior brain states govern access to working memory (ACCESS2WM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The ability to temporarily maintain and manipulate information in working memory (WM) is critical for adaptive behaviour. Because WM has limited capacity, it is essential to understand the mechanisms that govern selective access to it. I hypothesise that 1) selective access to WM is governed by states of the brain prior to the encoding and retrieval of sensory information (in particular the phase and amplitude of neural oscillations in the different sensory cortices), and that 2) changes in these states provide a common neural substrate through which several cognitive variables affect WM. I will use magneto-encephalography (MEG) to investigate several key aspects of these central hypotheses in healthy human volunteers. This will advance our understanding of the neural and cognitive mechanisms that govern selective access to WM and could ultimately be used to present relevant information when the brain is most susceptible to incorporate this into WM. The project will be carried out at the Oxford Centre for Human Brain Activity, together with leading scientist in the electrophysiological study of WM (Anna Christina Nobre and Mark Stokes) and the analysis of MEG data (Mark Woolrich). This will allow me to not only perform the proposed research to the highest standard, but also to further develop several key skills (broaden my conceptual horizon, acquire novel analysis techniques, establish long-term collaborations, translate research, etc.) that will further my independence as a researcher and place me in the ideal position to start my own research group within few years after the fellowship.

Keywords: working memory,selective attention,neuronal oscillations,human electrophysiology,magnetoencephalography,perception,sensory cortex
Effects of confinement on inhomogeneous systems (CONIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Argentina,Ukraine,Spain,Belarus,Poland,France
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 675000.0
EU funding (EUR): 675000.0
Participants: 9
Project status: CLOSED

The objective of the project is determination of universal features and specific properties of various systems spontaneously ordering into spatially inhomogeneous structures (mobile ions in solids, ionic liquid mixtures, soft-matter and biological systems), with special focus on effects of confinement. There is striking similarity between properties of the above systems despite different interactions and length scales of inhomogeneities. The fundamental relation between structural inhomogeneities and mechanical and thermodynamic properties is not fully understood because the exchange of knowledge between the solid-state, liquid-matter, soft-matter and biophysical communities is limited. Theoretical and simulation approaches developed by 3 EU MS + 1 AC + 2 TC groups are closely connected or complementary. We use mean-field, liquid-matter, DFT, integral equations, field and collective-variables theories, molecular simulation approaches, and experimental methods of electrochemistry. We will share our experience in constructing/modifying, solving and verifying experimentally models for different complex systems. The new results and theoretical approaches will help in future studies of various inhomogeneous systems. The first work package concerns systems spontaneously forming ordered patterns, from thin films on solid surfaces through particles on interfaces to biological membranes and arid ecosystems. The pattern formation can be exploited in innovative technology. In the second work package we will investigate ionic liquids/ionic-liquid mixtures, especially near charged surfaces and in porous media, and mobile ions in intercalation compounds. Mobile ions and ionic liquids in porous electrodes are potentially important in innovative electrochemistry. EU/TC knowledge transfer will be by joint theoretical, simulation and experimental studies. Open workshops will be organized. Long term visits of young researchers and joint supervision of PhD students are planned.

Keywords: inhomogeneous systems,confinement,self assembly,ionic systems
Capacity-building of the financial ecosystem and its participants for improving innovative SME´s access to alternative forms of finance in Europe with focus on SE and CEE (ALTFInator)

Framework: Horizon 2020 — Industrial Leadership
Action type: Coordination and support actions
Countries involved: Italy,Ukraine,Spain,Estonia,Norway,Lithuania,Romania,Hungary,Slovakia,Netherlands,United Kingdom,Portugal
Call: Improving access by innovative SMEs to alternative forms of finance (H2020-ALTFI-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 1498939.78
EU funding (EUR): 1498939.78
Participants: 13
Project status: CLOSED

The objective of the project is to design, develop and implement a capacity-building strategy to increase the capacity of the financial ecosystem and its participants in South, Central and Eastern European countries for provision and absorption of alternative forms of financing (AF) for innovative SMEs Sub objectives and outputs: 1: To map and analyse the framework conditions and establish the capacity-building strategy and implementation plan • Capacity building strategy and implementation plan for South and Central and Eastern Europe, in particular PT, ES, IT, LT, PL, SK, HU, RO, UA (consortium presence), GR, LT, SLa, CZ, HR, BG, RS; BA, AL, MK (consortium outreach) • Validation with 120 participants • Adapted strategy and plan in line with assessment 2: To provide cross-European information architecture with materials, resources and online tools for capacity building and matching of innovative SMEs to AF schemes and their providers • ALTFInator web platform with interactive library and information, matching and data exchange tool set: 3: To engage and broaden the stakeholder community, complemented by equal increase of knowledge, capacity and partnerships in support of provision and absorption of AF for innovative SMEs • Awareness raising campaigns focusing on 3 600 key stakeholders • 8 national workshops with 240 participants • 2 international best practice workshops with 60 participants • 8 public roundtables with 40 participants each • Policy makers hearing at the EuroParl with 30 participants. • MOOCs for AF providers with 500 participants • 4 webinars for group coaching of SMEs with 120 participants 4: To review the impact of the implementation and provide the evidence-base for adaption and sustainability of the scheme in the light of experience • KPI´s 5: To provide stakeholders at European and International level, with the information concerning the ALTFInator activities, events, achievements, respective web platform, material and tools • Outreach to 100.

Keywords: alternative finance,access to finance,innovative smes
Enzyme design and engineering by implementation of non-canonical amino acids in protein scaffolds (THIAZOLIUMenzyme)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-15
End date: 2021-09-14
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

The design of enzymatic catalysts and protein therapeutics with tailored, new-to-nature properties is a long-standing goal in enzymology and cell biology. Nature generally uses 20 amino acids as building blocks for protein synthesis. However, this portfolio limits the options for engineering proteins with ‘un-natural’ activities. Recent developments in the expansion of the genetic code have the potential to revolutionise the design of novel enzymes; by reprogramming the genetic code, we could convey novel functionality into proteins and extend their properties. This project aims at incorporating thiazolium amino acids into the active site of a promiscuous and highly evolvable de novo enzyme, namely the RA95 (retro)-aldolase, for orchestrating organocatalytic transformations of clinical and industrial interest. Such reactions, conventionally mediated by non-enzymatic, small molecule N-heterocyclic carbene (NHC) catalysts require high temperature and catalyst loading. An engineered enzyme with the ability to catalyse such chemistry may overcome the drawbacks of these abiological catalysts, serving as a ‘greener’ biocatalytic alternative, and also perform the desired reactions in cells for medicinal purposes. This initiative will pave the way for development of general strategies for creating enzymes with unique properties and provide a tool-box for efficient, environmentally-friendly and bioorthogonal organocatalysed reactions. It is anticipated that the generated artificial biocatalysts will have attractive applications in research, medicine and industry.

Keywords: directed evolution,enzyme design,protein engineering,non canonical amino acids,biocatalysis
The next generation of Antenna Structures Suited for Energy harvesting and signal Transmission in miniaturized chips for use in medical devices (ASSET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Norway
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2020-02, 2020)
Start date: 2021-01-04
End date: 2022-03-03
Duration (months): 14.0
Total project cost (EUR): 166712.5
EU funding (EUR): 116698.75
Participants: 1
Project status: CLOSED

The medical industry has seen a steady uptake of devices that capture physiological data in both automated and continuous data streams. Such devices can largely lower the monitoring burden and are valuable in a wide spectrum of health states making continuity of monitoring increasingly expected. Compounding this rise in continuous data is the growth of parameters that can be monitored non-invasively with high accuracy, many of which correspond to clinically relevant insights. Therefore, with more data that can be continuously, non-invasively and accurately monitored from patients’ skin comes the possibility of big data insights in healthcare, leading the way to better decisions and improved care. A critical challenge with the increase of wireless sensors on patients’ skin is power management, related to safety, disposal, resource availability and practical aspects. With increased efficiency of the electronic components that drive both sensing and data transmission, comes the possibility of wireless energy harvesting, which enables sensing medical devices to become battery-less. ONiO is a medical sensor company based in Norway designing and manufacturing medical sensor systems. Common to all sensors in our R&D pipeline is that they 1. measure one or more physical properties with high fidelity in a single ASIC, 2. operate without batteries and 3. wirelessly report data. These continuously measuring sensors will be integrated into skin worn patches, fitting the Needs of healthcare and consumer markets, while being disposable in household waste. ONiO needs to develop an integrated antenna for its sensor platform, by conducting research on far-field multiband RF energy harvesting. Such energy harvesting antenna is a critical building block for the ultra-low power solutions not requiring a battery that ONiO is developing in-house. In that regard, the SME Innovation Associate Programme fits perfectly into our plan of boosting R&D activities within antenna design.

Keywords: semiconductors,microelectronics,antenna design,flexible substrates,medical devices,on skin applications,energy harvesting,self powered,wireless,multi sensor
Imaging of multiple mRNA targets using SERS nanoparticle labels and in situ hybridization in human cancer tissue sections (RISH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-06
End date: 2017-08-05
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Early cancer diagnosis greatly increases the chances for successful treatment and personalised therapy. RNA molecules have emerged as new candidate biomarkers for detecting a wide variety of cancers, due to their critical role in cell growth and development. In situ hybridization techniques for mRNA detection provide detailed spatial and temporal information on RNA expression with single-molecule sensitivity, however the traditional techniques that utilise fluorescence probes and quantum dots lack of high multiplexing capabilities. RISH seeks to develop a methodology that allows sensitive multiplex detection, quantification and distribution of cellular mRNA biomarkers utilising surface-enhanced Raman spectroscopy (SERS) nanoparticle (NP) labels. SERS NP-labels consist of metal nanoparticles modified with a self-assembled monolayer of Raman reporters and are sensitive and robust labels that offer great multiplexing capacity. Molecular beacon hybridization probes specific to mRNA targets will be conjugated to SERS NP-labels to allow optical detection utilising Raman microscopy in human cancer tissue sections. The mRNA expression levels will be correlated with those from fluorescence in situ hybridization and the respective protein expression levels after immunohistochemistry. The research proposal is highly multidisciplinary and includes aspects of spectroscopy, optics, biochemistry, nanotechnology and pathology. The research fellow plans to work closely with experts from both the hospital and the industry to apply this methodology in the diagnosis of initially breast cancer and of different types of cancer at a later stage.

Keywords: surface enhanced raman spectroscopy,raman,tissue,mrna,nanoparticles,cancer,imaging,in situ hybridization,fluorescence,biomarkes,microscopy,biosensor