Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Therapeutic discovery for cholangiocellular carcinoma (CANDY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-08-01
End date: 2024-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cholangiocarcinoma (CCA) is one of the deadliest cancers comprising a heterogeneous cluster of malignancies that are distinct to hepatocellular carcinoma (HCC) and that can emerge at any point in the biliary tree. While not very common, CCA is responsible for 2% of cancer-related deaths worldwide annually and rising. The incidence in European countries is increasing rapidly ranging from 1 to more than 4 cases/100,000. CCA is mostly diagnosed very late resulting in aggressive disease progression, poor treatment response, and dismal prognosis with a median survival of less than 2 years. Curative hepatic resection is an option in 10-30% cases and is mostly linked to recurrence within 12 months in over 50% of patients. For most patients, diagnosis will occur when the disease is already too advanced, and the only options are chemotherapies or palliative care. Current standard-of-care for CCA is unsatisfactory with very limited efficacy and adverse effects. Recently approved second-line therapeutics slightly improve outcome but are only suited to a small subset of CCA patients. Thus, there is a major unmet medical need for novel therapeutic strategies to improve patient outcome. Based on a robust data package obtained in a panel of CCA models within ERC HEPCIR, here we will explore the use of a novel class of compounds exploiting a unique and differentiated first-in-class mechanism-of-action and validate their efficacy in vivo as a first-line therapeutic for CCA. Proof-of-concept studies will be performed in state-of-the-art patient-derived models combined with scRNASeq and proteomics. The data obtained will serve as a pre-IND data package for this indication. An established collaboration with a pharma partner will ensure fast-track completion of the preclinical development towards IND. Collectively, ERC PoC CANDY will deliver completed proof-of-concept for a novel therapeutic approach for CCA which has the potential to transform patient care.
Late Ottoman Palestinians: Social and Cultural Dynamics in an Eastern Mediterranean Society during the Age of Empire, 1880-1920 (LOOP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1996496.0
EU funding (EUR): 1996496.0
Participants: 1
Project status: SIGNED

In the Eastern Mediterranean, the four decades between 1880 and 1920 were a time of imperialism, globalisation and Ottoman state building, but also of profound social differentiation, fuelled by an unprecedented degree of human mobility and migration. Therefore, in this period we find the roots of many social formations that have remained relevant until the present. My focus is on the individual and collective practices for coping with various challenges and on census-taking as a social process. It will open up new perspectives on social and cultural dynamics in late Ottoman Palestine, in a historical context defined by European imperialism, Ottoman state building and globalisation. The main research question is: which social strategies did late Ottoman Palestinians employ, across ethnic, religious and class divides, to confront challenges on the individual and collective levels? These include fostering social advancement of one’s household or coping with economic stress. My hypothesis is that an accumulation of individual actions led to the constant emergence and re-emergence of social formations. Using the census process and its data I will establish yardsticks that will make it possible to compare social practices across the region and beyond, and thus contribute to ongoing efforts to write a global social and cultural history and it will develop a theoretical framework and methodological standards that will be useful for similar research projects. Specifically, the project aims to set new standards for how to realise the vision of an HGIS for the entire Ottoman Empire. Enabling comparison with other sources it may also offer intriguing new perspectives for the study of colonialism, notably under the British Mandate.

Keywords: palestine ottoman empire social history cultural history economic history social differentiation social practices social strategies census census taking as a social process historical gis
Initiative to Support, Promote and Integrate Researchers at Risk in Europe PLUS (InspireuropePlus)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Ireland,Belgium,Sweden,Germany,France,Greece,United Kingdom,Spain,United States
Call: MSCA Researchers at Risk 2021 (HORIZON-MSCA-2021-RR-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1299749.0
EU funding (EUR): 1299749.0
Participants: 10
Project status: SIGNED

Inspireurope+ will strengthen and coordinate support in Europe for researchers at risk. Building on the work undertaken by Inspireurope (launched under MSCA in 2019), Inspireurope+ proceeds from the view that excellence in research depends upon free and open scientific debate and requires a diversity of perspectives and methodologies to flourish. The need to expand support for researchers at risk is urgent, and the value of a coordinated effort across countries and institutions that is dedicated to providing support for researchers at risk has never been clearer. Researchers at risk are scholars, scientists and researchers who face threats to their life, liberty, or research careers, including those who have been displaced because of such threats. Persecution, harassment, intimidation and violence directed at scholars, scientists and researchers not only place individual lives and careers in jeopardy. Such threats and abuses also put the very future of research at stake. Inspireurope+ will combine forces across national and institutional boundaries to respond. Through guidance, training and consultations with over 300 researchers at risk, Inspireurope+ will help to build up the skills and knowledge needed to facilitate access to European, national and institutional funding and support. Through guidance and advice for over 400 employers in the academic and non-academic sectors, Inspireurope+ will increase institutional capacity and preparedness to support researchers at risk. Through policy input to the national and European levels, Inspireurope+ will facilitate and encourage the development of new support programmes and improve the policy environment in Europe for researchers at risk. Project partners will leverage their vast networks to bring project outputs to over 30,000 people in more than 100 countries. Inspireurope+ will consolidate, diversify and multiply efforts to improve lives and career opportunities, together with researchers at risk.

Keywords: scholars,researchers,academic freedom,refugees,internationalisation at home,risk,freedom of scientific research,diversity,inclusion,equity,research talent
Accelerating Relational Databases with Real Memristive Processing-in-Memory (Real-Database-PIM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In the contemporary digital era, relational databases play a pivotal role in business applications, facilitating the management and analysis of intricate data sets in diverse sectors including healthcare, finance, and social media platforms. These databases comprise relations represented as sets of records and attributes, allowing for detailed data scrutiny and insightful business decision-making. However, the prevalent model of data analysis is beleaguered by lengthy execution times and considerable energy consumption due to the separation of data processing and storage, necessitating hefty computational investments. Addressing this, we propose an innovative approach leveraging processing-in-memory (PIM) techniques, specifically bulk-bitwise PIM, to hasten analytical processing in relational databases. Grounded in emergent nonvolatile memristive memory technologies, this method capitalizes on memory cell arrays for concurrent data processing and result storage, markedly diminishing data movement and consequently, time and energy expenditure. Our endeavor is to craft the memristive memory processing unit (mMPU), originally developed during the PI's ERC StG Real-PIM-System project, adept at accelerating relational database analysis, promising to deliver a computing system that is tenfold faster and a hundred times more energy-efficient at a fraction of the current cost, revolutionizing data analysis and offering substantial savings in both time and financial resources.
p-wave superfluidity and BCS-BEC crossover of ultracold polar molecules (MolPWSupFluid)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

P-wave superfluids of fermionic particles are a crucial subject of study in condensed matter systems, where fermions pair up with nonzero angular momentum and exotic quantum phenomena like Majorana zero mode are predicted to exist. Investigation into the p-wave superfluids not only helps unravel the underlying mechanism of high-T superconductors but also provides insights into the fundamental symmetry of elementary particles. Over the last decade, ultracold quantum gas of polar molecules with controllable long-range dipolar interaction has emerged to be a powerful testbed to investigate such exotic quantum phases. At sufficiently low temperatures, fermionic molecules can pair up with p-wave symmetry and form a many-body BCS state. With the molecular scattering controlled with field-link resonances, the BCS-BEC crossover of diatomic molecules can be achieved. However, cooling of these fermionic molecules to this regime and the detection of their emerging properties remains challenging. The main goal of MolPWSupFluid project is to cool polar fermionic NaK molecules to unprecedentedly low temperatures and study the many-body behavior with strong dipolar interaction including p-wave superfluidity and their crossover to a Bose-Einstein condensate of tetratomic molecules. This project will focus on technical advancements in microwave field control, enabling state-of-the-art evaporative cooling of dipolar molecules and facilitating the precise manipulation of molecular scattering with microwave-induced field-link resonances. With successful cooling of the NaK molecules below the superfluid critical temperature, we will investigate the anisotropic pairing property and the Higgs mode excitation of the molecules with critical velocity and Bragg spectroscopy. Finally, we will investigate the topological property of vortex in the p-wave superfluid and the non-Abelian statistics of Majorana zero modes with braiding operations.

Keywords: ultracold quantum gas of dipolar molecules,bcs bec crossover,p wave superfluidity,field linked molecules,higgs modes,majorana zero modes
Robotics and Artificial Intelligence for Critical Asset Monitoring (RAICAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,Spain,Greece,United Kingdom,France,Italy,Switzerland,Germany
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2128255.2
EU funding (EUR): 2128255.2
Participants: 17
Project status: SIGNED

This project aims to develop technologies which will enhance the operational capabilities of mobile robots for use in the inspection and maintenance of industrial facilities. A major task in many industrial environments is the retrieval of samples for chemical or biological analysis. Surface swabbing is often conducted manually, but this creates limits on the number of samples that can be taken and their location. There are often many places that can't be reached by people either due to the location (very high, or in confined/restricted access spaces) or environmental hazardous (such as heat or radiation). This project will develop a multi-domain, multi-agent robotic sample retrieval system that will be able to obtain samples across a range of environments. These samples will either be stored for ex-situ analysis in labs or taken to mobile labs for in-situ, real-time analysed. Due to the nature of the operational environments, full autonomy is not desirable, so shared autonomy (human-in-the-loop) will be required. The primary application focus will be nuclear environments, however the technologies will be applicable to many other sectors include petrochemical, offshore and agriculture.
Just transition to a green and digital future for all (READJUST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Netherlands,Finland,Germany,Belgium,Poland,Spain
Call: Tackling inequalities in the green and digital transitions (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-03-01
End date: 2027-08-31
Duration (months): 42.0
Total project cost (EUR): 3210825.75
EU funding (EUR): 3206023.87
Participants: 10
Project status: SIGNED

The policies driving the green and digital transitions, or twin transitions, are intended to level the field to achieve the European Growth Model and attain the EU Green Deal and the UN’s SDGs. However, these policies have had unintended and unforeseen effects, creating new inequalities and/or aggravating existing ones. Those primarily affected are social groups already at risk and EU’s most vulnerable regions. Public authorities and policy-makers at local, national and European levels therefore need evidence-based understanding of these inequalities and concrete ways to prevent and/or mitigate these. The READJUST project aims to suggest policy options for overcoming these (potential) trade-offs between efficiency and equality in twin transitions, in the key sectors of mobility and agri-food. The green and digital policies are intended to level the field for attaining SDGs; however, they may return uneven distribution of access to the transitions and their benefits. READJUST aims to suggest options for overcoming the perceived trade-off between efficiency and equality in policy and to make inclusive growth a reality. Policymakers portray a future that is green and digital for the EU, and they aim to continuously contain the unintended consequences of the green and digital transitions in terms of inequalities. Generating zero negative effects on the climate can be efficiently achievable by twining green and digital transitions. Nonetheless, individually and jointly, the transitions might widen the existing inequality gaps. This project aims to contribute to policies for fair and just twin transitions to mitigate existing inequalities driven by the twin transitions and minimize the transitions’ unintended consequences for equality. In this project, we strive to address the inequalities created or exacerbated by the twin transitions policies in certain domains. Policies of green and digital transitions which are aimed at the growth of the entirE, or its subsections.

Keywords: twin transition spatial inequalities inequality index policy tracker policy roadmap
Privacy-Preserving Human MObility Trajectory Data GeneratOr (PHOTO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-04-01
End date: 2026-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

People travel and leave their location history as mobility trajectory data. This data is invaluable for a wide range of location-based services, including city planning, traffic control, disease transmission and optimal control, trade area analysis, location-based marketing, and tourism, consequently leading to the rise of new business models. Recognising these opportunities, governments and industries have increasingly invested in exploring data-driven solutions. However, data challenges persist due to reduced data resolution from privacy concerns, high deployment and processing costs, and conflicts of commercial interests. Recently, ethical considerations regarding human location data have become even more critical. It remains unclear how organisations, regulators, and policymakers can effectively support the use, sharing, and reuse of location data across the geospatial ecosystem in ways that maximise public benefits. There is an urgent need to address these spatial data (not limited to trajectory data) access challenges, particularly for researchers and data analysts. We propose using synthetic data sets as an alternative to the original data sets, which could provide equal access, lower costs, and minimise ethical risks. Along this long-term pathway, this project aims to develop a prototype human mobility trajectory data generator, producing synthetic human trajectory data from original mobile in-app data. The synthetic data should enhance the original data while preserving essential human mobility patterns. The basic data will be in the form of trip-activity chains. Derived data sets could be in any commonly used format, e.g., counts, origin-destination matrix and indicators, meeting various applications in urban analytics and eliminating ethical concerns. There is a broad range of potential end-users, including the transport planning department, local governments and organisations, mobility service and facility providers and ITS-relevant industries.
Create a Symbiosis where PV and agriculture can have a mutually beneficial relationship (SYMBIOSYST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Italy,Belgium,Netherlands,Spain,United Kingdom
Call: Novel Agro-Photovoltaic systems (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5745458.67
EU funding (EUR): 4827668.0
Participants: 18
Project status: SUSPENDED

The decarbonisation of the energy sector is one of the top priorities at various political levels including at the European level. Photovoltaics (PV) is widely seen as one of the key technologies to drive the energy transition. The difficulties arise when the targets for PV (usually set at national level) needs to be put into practice at regional / local level. Although the PV rooftop potential is extremely large and could potentially contribute to the ambitious targets, the rate of installation of PV rooftop systems will not be fast enough to support a rapid transition. On the other hand, large utility-scale PV installations in open fields are not an option in many regions. It is in this context that the concept of Agrivoltaics is emerging. What several decades of efforts developing Building Integrated PV (BIPV) products and systems for rooftops and facades have taught us is that there are multiple levels of integration and various stakeholders across the value chain which can all generate significant barriers to widespread adoption . Agrivoltaics is in fact in the unique position to learn from the past mistakes made with BIPV which delayed the development of cost-effective BIPV solutions and market acceptance. In SYMBIOSYST we will not develop solutions that are highly customized as this would drive the costs up. We will rather innovate by adapting standardized cost-effective solutions in terms of PV modules, mounting structures and Operation and Maintenance (O&M) practices to the specific needs of various crops in different climates and landscapes. We will also find aesthetically pleasing solutions that can be mass manufactured and integrated with the agricultural land in a harmonious way while maintaining the primary goal of farming. The interdisciplinary consortium in SYMBIOSYST is composed of partners across the value chain with decades of experience in agriculture, precision farming, PV modules and systems, social science and integrated PV applications.

Keywords: sustainability,energy targets,sustainable agriculture,decarbonisation