Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Origin of Magnetic strUctureS in the ISM obscuring the Cosmic DAwn (MUSICA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Croatia
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-01
End date: 2022-01-31
Duration (months): 24.0
Total project cost (EUR): 147463.68
EU funding (EUR): 147463.68
Participants: 1
Project status: CLOSED

MUSICA will orchestrate an MSC-Action where the deepening of our knowledge of the local Universe will play together with unveiling the cosmic dawn. We will focus on the origin of new structures, stains, in the diffuse Galactic interstellar medium (ISM) recently revealed by the LOFAR radio telescope and model their contamination to the observations of the Epoch of Reionization. The study of the diffuse ISM is key for pivotal astrophysical problems, such as the inefficiency of the star formation process. The ISM fills the Galaxy with cosmic rays, multiphase gas, and dust particles, all coupled with magnetic fields. It is through their interactions that a complex cycle, involving phase transitions, magneto-hydrodynamic (MHD) turbulence, and gravity, is expected to convert diffuse/warm matter into denser/colder regions, where stars form at a rate of only a few solar masses per year. In theory, magnetic fields in the ISM may explain such low star-formation rate. In practice, characterizing magnetism at the starting point of this cycle of matter has been a difficult observational challenge until now. Today, the Planck satellite and LOFAR are unique complementary datasets to investigate phase transition between warm/ionized and atomic magnetized ISM. MUSICA proposes an unprecedented joint analysis of the Planck/LOFAR data with the best-available kinematic data of the atomic and ionized hydrogen to investigate the MHD origin of the stains. By comparing observations with synthetic data from state-of-the-art MHD simulations of the ISM, MUSICA will (1) significantly advance our knowledge of structure formation in the diffuse ISM and (2) prepare foreground analyses for future cosmological probes, such as LOFAR and the SKA radio telescopes. Hence, funding MUSICA will allow partners to (i) start a scientific network across Europe (France/Croatia) in line with the H2020 priorities, (ii) do science on the front line and (iii) secure their research in novel international projects.

Keywords: galactic magnetic field,faraday tomography,dust polarisation,early phases of star,formation,magnetohydrodynamics,galactic foregrounds for cosmological 21cm experiments
Multi-scale Observation and Monitoring of railway Infrastructure Threats (MOMIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Spain,Italy,Spain,Italy,France
Call: Satellite and autonomous monitoring systems’ solution (H2020-S2RJU-OC-2017, 2017)
Start date: 2017-09-01
End date: 2019-10-31
Duration (months): 26.0
Total project cost (EUR): 599172.5
EU funding (EUR): 599172.0
Participants: 6
Project status: CLOSED

The MOMIT project will develop innovative products and solutions supporting the maintenance process of railway infrastructures. MOMIT concept is based on the exploitation of unmanned technologies as Earth Observation satellites and RPAS-borne sensors. Starting from collected data analysis, MOMIT will bring at cutting edge level the remote sensing technology: developing advanced post processing chains, data fusion, automation, defining new indicators from estimated parameters, MOMIT will design new operational workflows able to support intelligent asset management. MOMIT will adopt a multi scale approach: Satellite and RPAS data will be combined in order to maximize their benefits and characteristics. A first overall analysis (with satellite and over long sections) will guide the detailed analysis and trigger specific preventive actions. Thus, maintenance activities are guided by this combined analysis with a general optimization of resources. Effectiveness and efficiency of proposed solutions will be demonstrated by six main application cases, validated in a real operational environment: - Ground movements: interferometry derived by SAR satellite data analysis will adopt to define tools and indicators supporting the user for detailed analysis and preventive actions planning - Hydraulic activities: a combination of optical and radar satellite data will be used to monitor soil moisture and water bodies close to the track - Natural hazards: anomalies along the track related to natural phenomena (as vegetation growth) will be monitored by the use of satellite data. - Electrical system: RPASs will be equipped with innovative sensors to monitor electrical effects impacting on the infrastructure efficiency - Civil engineering structures: a combination of satellite and RPAS data will be used to identify possible criticalities to the infrastructure - Safety: anomalies and illicit activities along the track will be monitor by the use of optical a radar satellite data

Keywords: satellite data,data fusion
Hidden Emissions of Forest Transitions: GHG effects of socio-metabolic processes reducing pressures on forests (HEFT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Austria,Austria
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1401941.0
EU funding (EUR): 1401941.0
Participants: 2
Project status: SIGNED

A forest transition, i.e. forest expansion after a long period of deforestation, has occurred in many, mostly industrialized countries. Forest transitions have recently resulted in declining rates of global net deforestation and contributed to carbon (C) sinks in terrestrial ecosystems. Studies have shown the concurrence of forest transitions and industrialization processes, but the systemic links between forest transitions, their underlying socio-metabolic processes and associated greenhouse gas (GHG) emissions have been neither systematically explored nor quantified. HEFT introduces the idea of “hidden emissions of forest transitions”, i.e. the GHG emissions from socio-metabolic processes reducing pressures on forests. Hidden emissions may stem from processes such as substitution of fuelwood by modern energy sources, intensification of agriculture, and externalization of biomass production to remote regions. Building on the concept of socio-ecological metabolism, HEFT develops a consistent methodological framework to quantify the full GHG emissions and sinks from socio-metabolic and ecological processes in the course of forest transitions, within which their hidden emissions are identified. Forest transitions in multiple contexts are analyzed at local, national and supranational scales: in Europe since c. 1850, North America since c. 1880, and South East Asia since 1980. A coarse global-scale assessment complements the regional case studies. We will integrate sources and analytical methods from environmental and social sciences as well as the humanities to analyze context-specific trajectories and general features of socio-ecological GHG budgets and their respective socio-political contexts since the onset of forest transitions. The sound understanding of hidden emissions will be used to identify the least GHG-intensive trajectories and to draw lessons for future climate-friendly forest transitions.

Keywords: forest transition,socio ecological metabolism,land use change,full carbon accounting,long term socio ecological research
Integration of Nano- and Biotechnology for beta-cell and islet Transplantation (iNanoBIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Belgium,Hungary,Hungary,Hungary,France
Call: Nanotechnologies for imaging cellular transplants and regenerative processes in vivo (H2020-NMBP-2017-two-stage, 2017)
Start date: 2017-10-01
End date: 2023-03-31
Duration (months): 66.0
Total project cost (EUR): 6999997.5
EU funding (EUR): 6999997.5
Participants: 9
Project status: SIGNED

The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model. The project will develop1) novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans; 2) develop and validate the application of state-of-the-art imaging technologies facilitating the provision of new regenerative therapies to preclinical large animal models and patients; 3) directly contribute to the opening of a new market sector for i) imaging equipment (SPECT, PET/MR, optoacoustic imaging in preclinical large animal models and patients), ii) nano-imaging molecule supplies (nanomolecules allowing multimodality imaging of specific cell types with high sensitivity), iii) validated transplantable in vitro differentiated human beta-cells and porcinexenotransplant islets thus will reinforce the European healthcare supply chain for regenerative medicinal products. The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area. The consortium of 5 SME and 3 Academic partners is coordinated and driven by the industrial partners from the field of nanotechnology, imaging and stem cell technologies, providing a perfect match and unique combination addressing the scope and expected impact of the call and providing TRL 3/4 starting points for the key technological elements, and expect to arrive to TRL6 levels of validated technologies ready for marketing by the end of the project.

Keywords: nanomolecules,imaging,diabetes,pancreatic islets,beta cells,spect,acustic imaging,porcine,xenotransplantation,ipsc,optoacoustic imaging
A real-time ground motion disaster mitigation system based on satellite, drone and ground radar images for industry safety and efficiency (MotionMapper)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Spain
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Several significant Industries rely on large scale, continuing, and fully safe operations in and around geological sites. These are the Mining, Construction and Oil & Gas Industries. With multiple accidents and non-complete monitoring of how their operations are impacting the terrain, the issue is far from resolved. Dares, a European company formed by staff with multiple years’ of experience in the industrial remote monitoring field wish to change this. We have an excellent satellite-based remote monitoring(inSAR) solution under development, now we wish to add Drone, Ground Radar and near realtime processing to generate the complete wide area to local area monitoring and alerting solution. We are in a unique position to do this. We have both the academic and industrial skill sets. Now we wish to confirm the possibilities in real detail, to validate our business case across all our markets. We propose the public launch of MotionMapper in parallel to this phase 1 project as a key milestone in our plans to execute a high-value business opportunity which has the clear capacity to greatly increase our sales, to capture further investment and to drive our rapid expansion.

Keywords: radar sar,insar,copernicus,sentinel 1,ground survey,early warning,drones,remote sensing,earth observation,cloud computing
On-Chip Electronics, Photonics, Plasmonics and Antennas: A Novel Enabling Platform for sub-THz Signal Processing (ELEPHANT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2022-02-01
End date: 2027-01-31
Duration (months): 60.0
Total project cost (EUR): 1894375.0
EU funding (EUR): 1894375.0
Participants: 1
Project status: SIGNED

The ELEPHANT project aims at combining the best of four worlds by bringing together the fastest electronics, photonics, plasmonics and antennas to create a novel enabling technology for future THz signal processing. The THz range has a tremendous untapped potential for a breadth of applications, as next-generation wireless communications, sensing, security, medical imaging, and more. However, efficient transport and processing of THz signals is a major challenge to this date, as at those frequencies electronic circuits are inherently limited by high dispersion and material losses. As a consequence, current approaches still rely on low-efficiency discrete components, which suffer from limited power, high losses and very high costs. While photonics allows low-loss transport of THz frequencies over large distances and broadband processing, today’s electronic-photonic platforms do not offer the required conversion speeds. Current efforts using organic materials have not proven sufficient stability and scalability. I plan to solve the challenge of THz signal processing by creating a novel integrated THz platform that allows to convert THz signals to the optical domain efficiently and with high fidelity, and to process them using a low-loss photonic processing core with THz bandwidth. The project fully builds on my cutting-edge results on photonic signal processing blocks with THz bandwidths using compact (10s µm-long) silicon photonics nanowires, and my recent demonstration of plasmonic modulators offering 500 GHz speeds, the fastest to date. I will create novel architectures suitable for analog processing and realize them in a scalable manner on bipolar CMOS platforms, together with THz antennas for wireless interfacing, and high-speed amplifiers to achieve the signal powers needed in real-world applications. The new platform will impact all the crucial THz fields, and it will be put to the test by creating the first photonic-wireless THz beamforming transceiver.

Keywords: microwave photonics,antennas,integrated optics,silicon photonics,plasmonics,signal processing
Suturing with Light (SWeetLight)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy,Italy
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The proponents aim to establish an international leading company in the field of innovative medical devices for laser eye surgery, keratoplasty in particular (cornea transplantation): the objective is to become pioneers in the field of ophthalmic surgery with a novel surgical technique of cornea laser welding for keratoplasty called SWeetLight (suturing with light). The specific aim is realise a medical device able to: • improve the quality and the overall precision of the keratoplasty, • standardize the surgical treatment by enhancing surgeon skills using robotic platform adopting collaborative control system to optimize the welding task of corneal wounds. • strongly reduce the risk of rejection and also of astigmatism, also respecting and preserving the donor’s cornea, • reduce the duration of the post-hospitalization phase: faster and safer visual recovery (fast “back to work”) • reduce the dependency of the intervention from the surgeon skills. From “business” point of view the objective is to reach the Break Even Point (BEP) at the end of year #2, and a value of revenues of € 4 million at the end of year #5.

Keywords: keratoplasty,eye surgery
Skeletal Muscle Inflammation: ambivalent roles in Exercise and Diabetes (SMILED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

In Europe, 52 million people are living with diabetes, with more than 90% of them having type 2 diabetes (T2D), a multifactorial disease associated with obesity and sedentary lifestyle. It leads to severe complications such as cardiovascular events and constitutes an unmanageable economic burden. Skeletal muscle inflammation is emerging as a potential contributor to T2D. Inflammation occurs during exercise and repair and is a hallmark of myopathies, suggesting that it plays crucial roles in skeletal muscle homeostasis. Despite the fact that exercise is associated with inflammation, physical activity has beneficial effects on T2D, which highlights the ambivalent role of muscle inflammation in controlling glucose homeostasis. Epigenetic processes are potential molecular links between diseases and environmental factors such as diet and exercise. Abnormal promoter methylation of inflammatory genes was recently suggested in adipose tissue during obesity, but little is currently known about epigenetic regulations in muscle during exercise and diabetes. Surprisingly, it is unknown whether there is any parallel between local inflammation of muscle and T2D and no therapeutic strategies currently target skeletal muscle for T2D treatment. The overall aim of this proposal is to determine the interaction between inflammation and the metabolic response to exercise and T2D to define potent interventional strategies that can improve insulin sensitivity. It will identify what type of inflammatory response induces the greatest metabolic effect on signal transduction and expression of genes through profiling DNA methylation, chromatin structure and small RNAs. It will use primary cell cultures from human biopsies to (1) obtain proof of principle that the beneficial effect of exercise on metabolism is dependent on inflammation, and (2) translate these discoveries into innovative exercise and anti-inflammatory intervention strategies to improve insulin sensitivity.

Keywords: skeletal muscle,exercise,diabetes,inflammation,epigenetics
THE IMPACT OF THE ENVIRONMENT AND ONCOGENESIS ON CANCER CELL DIVISIONS (IEOCCD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Mammalian cells must round up to divide by remodeling their adhesions and their cytoskeleton to form a stiff actin cortex. Mitotic rounding provides the space necessary to develop a mitotic spindle to undergo symmetric chromosomal segregation. If mitotic rounding is impeded by physical confinement or preventing adhesion remodeling, defects in spindle assembly and chromosomal missegregation can lead to mitotic cell death. In cancer, the cells must divide in a challenging environment which can alter the way cells divide. Preliminary data show Ras- activated epithelial cells are able to round better compared to normal cells. This adaptation could protect the dividing cell from the physical environment and allow epithelial cancer cells to divide in the confines of the tumor and distant metastatic sites. Here, we aim to identify mechanisms that allow epithelial cancer cells to divide differently from that of normal epithelial cells. Potentially, this mechanism could be a powerful target if we are able to prevent cancer cell division without interfering with normal cell division. Preliminary data suggest Ras-ERK signalling could play a role in mitotic rounding of cancer cells. In this proposal, I will 1) investigate ERK signalling dynamics during mitotic progression, how it regulates mitotic rounding and effects on the following cell cycle 2) investigate how Ras-ERK signalling and the mechanism of cell division are affected by environment using microfabricated tools and 3) initiate oncogenic activation by over-expressing receptor tyrosine kinases commonly found over-expressed in cancer or constitutive activation of Ras/Raf and measure changes in Ras-ERK signalling and cell mechanics. By establishing a link between Ras-ERK signalling and mitotic progression, I will determine how oncogenesis affects Ras-ERK signalling dynamics and cell division to allow cancer cells to divide in a wide range of environments.

Keywords: mitotic rounding cell division ras mapk erk microfabrication cancer microenvironment