Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Spatial organization and Horizontal gene transfer of Antibiotic Resistance by ESBL in WasteWater (SHARE_WW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

The tidal increase of clinical antibiotic resistance is of serious threat to public health and should be viewed in an integrated system influenced by the environmental dimension of antibiotic (AB) resistance. This innovative proposal intends to address the current knowledge gaps concerning the biofilm spatial organization and interspecies interactions that underlie the antibiotic resistance strategy by extended spectrum β-lactamase (ESBL) producing bacteria thriving in wastewater treatment plants (WWTPs). The proposal has 3 objectives: Obj.1) Evaluate the impact of interspecies interaction of ESBL gene sharing by conjugation in the biofilm collective AB resistance and its interdependence with bacterial spatial organization; Obj. 2) Evaluate the interspecies interactions concerning the cephalosporin resistance at a functional level by following the expression and localization of ESBL and other AB resistance related proteins; Obj. 3) Evaluate the potential of WWTP as hotspots for AB resistance by assessing the sharing of ESBL genes and their expression. Such objectives will be achieved by the implementation of 3 work packages that address each one in a stepwise approach with the use of state-of-the-art techniques, based upon the most up to date references. European Commission (EC) have declared antimicrobial resistance as an important global economic and a societal challenge, that must be tackled by a multi-sectorial approach, where the environmental sector is included. The SHARE_WW project will make important advances in the field of β-lactam AB resistance proliferation and environmental spread, by covering several scientific gaps referred in the most up to date literature. In line with the multi-sectorial EC approach, the results from this project will have great relevance for research and practitioners from other sectors like public health, food safety, biotechnology and industry, and are therefore of great relevance to the work program.

Keywords: multispecies biofilm,wastewater,species interactions,spatial organization,beta lactam resistance,conjugation,extended spectrum beta lactamases,biofilm antibiotic resistance related proteins
Elaboration and degeneration of complex traits: The visual systems of lizards and snakes (Evol-Eyes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 258107.4
EU funding (EUR): 258107.4
Participants: 2
Project status: CLOSED

In “On the origin of species” Charles Darwin used the human eye as an example of a complex character the evolution of which would have been hard to explain. Since then the vertebrate eye and the origin of vision more broadly held a central role in evolutionary biology. Recent advances in genomics, developmental biology and physiology, have allowed some advancement in our understanding of the origin of animal vision that however, is still patchy at best. Surprisingly, modern integrative studies have largely overlooked the visual systems of the Squamata (i.e. the lizards and snakes), a group comprising ~25% of terrestrial vertebrates, displaying exceptional diversity, and with greater variation in eye morphology and retinal photoreceptors than all other vertebrates combined. I propose to use the powerful but overlooked squamate system to answer major questions in visual science. I will integrate genomic, physiological and anatomical data to understand the genomic underpinning of phenotypic variation in the vertebrate visual system the relative roles of adaptation and constraints in the origin of novel visual phenotypes, and to understand whether complex visual systems can be re-elaborated following evolutionary degeneration. This is a blue skies project however, studying the evolution of the exceptionally plastic squamate visual system, will generate information that can be applied to other animals, and perhaps most importantly, used to increase our understanding of the human visual genetic disorders under the newly emerging Phylomedicine paradigm.

Keywords: evolution,vision,squamates,eye anatomy,visual physiology,comparative genomics,transcriptomics
ECO sustainable multi FUNctional biobased COATings with enhanced performance and end of life options (ECOFUNCO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Italy,Germany,Germany,Italy,Italy,Spain,Israel,Italy,Türkiye,Belgium,Croatia,United Kingdom,United Kingdom
Call: Develop functional molecules for bio-based coatings outperforming existing products and meeting market requirements (H2020-BBI-JTI-2018, 2018)
Start date: 2019-05-01
End date: 2022-07-31
Duration (months): 39.0
Total project cost (EUR): 5567436.25
EU funding (EUR): 4613778.25
Participants: 19
Project status: CLOSED

The overall objective of project ECOFUNCO is to select, extract-functionalise molecules (proteins, polysaccharides, cutin) from highly available, low valorised biomass such as tomato, legumes, sunflower etc for the development of new bio-based coating materials to be applied on two different substrates (cellulosic and plastic based), with improved performances compared to currently available products and at the same time with more sustainable end of life options. The products to be developed in the project are in particular: Antimicrobial-antioxidant coatings based on chitin nanofibrills, and/or chitosan, functionalised MC, for cellulose tissues (personal care), paper and cardboard (packaging for fresh products like pasta, tableware), woven and nonwoven (sanitary), plastic substrates (bio-polyesters) for active packaging. Cutin based formulations for coatings water repellent (paper cups, service paper etc.), water vapour barrier (packaging) and protective properties (non-food packaging). Protein- based barrier adhesive for multilayer food packaging (bio polyesters based), with sustainable end of life options (composting, recyclability).

Keywords: biomolecules,barrier properties,antimicrobial,hydrophobicity,sustainability
Hydropower Extending Power System Flexibility (XFLEX HYDRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Spain,Austria,Germany,Spain,Switzerland,Switzerland,Switzerland,Switzerland,France,France,France,United Kingdom,Portugal,Portugal,Portugal
Call: Demonstration of solutions based on renewable sources that provide flexibility to the energy system (H2020-LC-SC3-2019-RES-IA-CSA, 2019)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 18162949.5
EU funding (EUR): 15103379.25
Participants: 20
Project status: SIGNED

The ultimate objective of the XFLEX project is to increase hydropower potential in terms of plant efficiency, availability and provision of flexibility services to the Electric Power System (EPS). The high Renewable Energy Sources (RES) scenario of the decarbonisation process relies on a drastic change of the European Union EPS with a massive integration of non-dispatchable RES and disconnection of the so-called conventional units, as greenhouse gases emitters. These changes influence drastically the provision of the power grid balancing, and challenge the EPS operations and safety. It is of upmost importance to provide reliable solutions to support the EPS with more flexibility services. Hydroelectric Power Plant (HPP) already significantly supports EPS flexibility in terms of regulation capability, fast frequency control, fast start/stop, fast generating to pumping modes transition, high ramping rate, inertia emulation, fault ride through capacity, etc. XFLEX aims to demonstrate an innovative methodology for system integration of hydroelectric technology solutions, variable speed being a key component and a reference, to provide further enhanced flexibility services assessed by a crosscutting analysis of their impact on both the technology and the market aspects. Innovative solutions also target an optimize maintenance plan to decrease the outage time and increase the availability of the plant. Demonstrations are scheduled in the cases of run-of-river, storage and pumped storage HPPs and they cover cases of refurbished, uprated and especially existing HPP to be applied and scaled to any unit size. XFLEX draws the roadmap for the exploitation of its solutions to all the European HPP fleet. A strategic dissemination plan is set to promote the deployment of the demonstrated solutions to stakeholders, to the scientific community and the public and to further support the communication in workshops, conferences, scientific journals, newspapers and various social media.

Keywords: hydropower,flexibility,energy system,balancing power,hydroelectric machinery,availability,performance,variable speed,maintenance intervals,outage time,digitalisation
Guided Data-Driven Safety at Sea (SAFEWAVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wave slamming impacts in high-speed boats has been recognized as a serious problem in maritime industry producing serious injuries and fatigue to operators and crew, and also mechanical and structural damages in vessels and on-board equipment. Some solutions exist in the market, such as shock absorbing seats, that mitigate the impact to some extent. However, they do not reduce the number of wave slamming accidents, as 96% of times its main cause is human errors. With 13 years of combined experience in the maritime industry we have developed Safewave, a software-based solution that provides operators real-time information and predictions of potential hazards ahead. Our device uses current and historical information of acceleration forces experienced from mechanical impacts, together with current and past sea-states and weather, engine and navigation data and analyse this information make intelligent data-driven predictions. Safewave does not mitigate the impact, but prevent it. Safewave has been conceived to be used on high-speed craft, with a vast potential user base of 18 million recreational vessels in Europe and the US alone. We have already been approached by several entities from universities, to insurance companies to maritime recue and guard association and bodies. After successfully testing our prototype in the sea, next steps to finalize Safewave development are: I) gather data and user feedback through zero-series testing for input and development of analytical and artificial intelligence functionality II) build a supply chain that fits our scalability potential and III) establish agreements with channel companies to distribute our solution through their clients facilitating our international commercialization. Safewave commercialization is anticipated to generate profits of €3.6 million by 2022, from sales in Iceland, Nordic countries, UK and USA.

Keywords: boats,safety,recreational boating,maritime hazard,vessel
SNETP Programming for Research and Innovation in Nuclear Technology (SPRINT)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Action type: Coordination and support actions
Countries involved: Germany,Belgium,France,Czechia,Netherlands
Call: Specific support to the work of the Sustainable Nuclear Energy Technology Platform (NFRP-2014-2015, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 607627.5
EU funding (EUR): 599550.0
Participants: 8
Project status: CLOSED

SNETP, the Sustainable Nuclear Energy Technology Platform, was confirmed in 2013 as one of the EC’s officially recognised European Technology Platforms, the only one in the nuclear fission sector. The SPRINT project aims at supporting SNETP in its roadmapping, networking, dissemination and communication activities. The essential purpose of the SPRINT proposal, in particular, is to support SNETP in the elaboration and wide adoption and use of its strategic roadmaps, as well as in strengthening its visibility and interactions with its members and external stakeholders. The project sets out four specific objectives: ensuring an inclusive and efficient process for producing strategic roadmaps; improving the ‘value proposal’ of SNETP for the fission R&D community in Europe; confirming SNETP as a key player within the international energy technology landscape; and enhancing the visibility and dialogue of SNETP towards a wider audience. Focusing on “value creation” and visibility for the Platform, SPRINT will pursue some of the activities initialised through the Euratom FP7 “SNETP-Office” and “SMILE” projects. SPRINT will support the platform, groups and members, with the development and dissemination of main strategic documents (i.a., the Deployment Strategy and the Strategic Research and Innovation Agenda). SPRINT will also strengthen and improve the interactions between its pillars/activities and will increase SNETP’s interactions with stakeholders (EU institutions and initiatives, international agencies, other platforms). Finally, SPRINT will propose new added value services to its members and will strengthen SNETP visibility by participating in major international events and updating its communication tools.

Keywords: snetp,programming,dissemination,roadmap,added value
Tree Roots: an analytical ‘culture’ of economy and religion – case-study Egypt 2050-1550 BC. (TRACER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-15
End date: 2018-11-14
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Indigenous and imported wood species were extensively used in Ancient Egypt for manufacturing objects of daily life and equipment for the afterlife, notably statuary and coffins. Despite the abundance and use throughout Pharaonic history, no global study has been carried out on this material. Indeed, in stark contrast to stone or metal objects whose material identification is always specified, research publications and museum displays most often accept a simple identification “wood”. When the type of wood used is specified, identification is rarely based on botanical analysis. As a result the entire history and archaeology of an art and medium are lost. With an innovative double methodology combining archaeometric and theoretical approaches, the TRACER project will analyze woodcraft as a societal "tracer" in Ancient Egypt during a key period of its history: the Middle Bronze Age (MBA). Analyze of woodcraft during this period which covers politically centralized (Middle Kingdom-MK) and decentralized period (Second Intermediate Period-SIP), will identify the impact of societal changes on wood crafts, closely linked with the political and religious development of the country. Two specific wood corpora will be investigated: 1) burial equipment from Upper and Middle Egypt, mainly coffins and statues; 2) settlement site finds from the largest town site with good preservation of organic material, Lahun, in Lower Egypt. Thus, the 2-years project TRACER will constitute the first move toward a previously unseen global project dedicated to wood in Ancient Egypt. The main objective of the TRACER project is to highlight how the specialized production in one material, carpentry, correlates with the other dimensions of its historical context (religious, political, cultural). The TRACER project will target woodworking as a test-case for assessing relations between social components in one archaeological well documented period of lower Nile Valley between 2050 and 1550 BC.

Keywords: woodcraft,coffins,statues,lahun,middle bronze age,egypt,workshops,wood as societal tracer,societal changes,craftmen,production,material analysis,religious thought,mapping,chrono typology
Nanoscale magnetic imaging with quantum sensors (NanoMAGIQ)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Switzerland
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2017)
Start date: 2018-06-01
End date: 2019-05-31
Duration (months): 12.0
Total project cost (EUR): 107500.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Magnetic imaging is a tool widely used in a large variety of applications ranging from basic material science, to electronic device testing, to medical diagnostic. But classical technologies fail to provide good enough resolution to address the nanometer scale. Yet today, this corresponds to the process size in the semiconductor industry: the new generations of transistors and memory cells all have features in the 10 nm range. Therefore, there is a critical demand for solutions going beyond current capabilities. Qnami develops sensors for magnetic imaging based on a quantum technology. This brings unique sensitivity and unique resolution. Our quantum sensors operate under ambient conditions, which simplifies use and maintains operation costs at a low level. Qnami’s ambition is to provide the semiconductor industry with analytical tools for design testing and failure analysis, and to help researchers exploring new avenues in material and life sciences. Our first product is a magnetic sensor with optical read-out, which combines nanometer resolution with a sensitivity to just a hundred atoms, limited by quantum noise. It is carved out of ultra-pure diamond, which brings two further advantages: robustness and bio-compatibility. The goal of this proposal is to evaluate the business potential of our innovation and prepare for investment rounds. The three main objectives of this proposal are 1) to deploy our technology and address a short list of >10 customers from a first market of expert academic users, 2) to evaluate the potential of the semiconductor segment and to engage with a first customer 3) to rationalize production costs and optimize the revenue model in order to ensure a sustainable and profitable business, and attract private investment.

Keywords: quantum sensing,magnetic imaging,optical sensors
Macrophage aging and rejuvenation (MacAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany,France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 2499994.0
EU funding (EUR): 1352846.78
Participants: 2
Project status: CLOSED

Tissue resident macrophages are essentially present in every organ of the body and perform critical functions in immunity, tissue homeostasis and regeneration. Recent evidence shows that resident macrophages can originate from embryonic progenitors and be maintained in tissues long term by local proliferation independently of monocytes. This self-renewal ability, however, appears to decline with age, with potentially major consequences for the response to infection, the resolution of inflammation and the ability for tissue regeneration. Understanding the decline of self-renewal in the aging macrophage may thus hold key elements for maintaining healthy tissue integrity. Drawing from analogies to stem cell self-renewal we want to decipher the molecular and cellular parameters of macrophage self-renewal and its decline with age. We want to understand the age-associated changes in gene expression and epigenetic identity of tissue macrophage populations with the ultimate goal to reverse age dependent decline in self-renewal and function. Results from my laboratory have identified transcription factors that control the access to a network of self-renewal genes that are also used in stem cells. Using several complementary genetic mouse models tapping into this network we want to investigate whether its activation in resident macrophage population in vivo can rejuvenate their self-renewal capacity and revert aging related changes. These approaches will be complemented by unbiased genome wide screens in vivo using latest generation CRISPR/Cas9 genome editing technology to identify new signaling pathways guiding macrophage self-renewal and aging. Using innovate combinations of genetics and adoptive transfer protocols we will test whether this knowledge can be employed to reverse macrophage dependent loss of immune competence and failed tissue regeneration with age. Our results will lead to new general insight and potential novel cellular therapies for degenerative diseases.

Keywords: macrophages,self renewal,stem cell biology,regeneration,infection,molecular genetics,genetic crispr,cas9 screen,alveolar macrophages