Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Oligonucleotides for Medical Applications (OLIGOMED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Belgium,Sweden,Poland,Sweden,France,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2025-06-30
Duration (months): 54.0
Total project cost (EUR): 4130663.4
EU funding (EUR): 4130663.4
Participants: 14
Project status: SIGNED

The use of synthetic oligonucleotides (ONs, short DNA or RNA strands) in the treatment of genetic diseases is a rapidly growing field, and the most promising alternative to gene therapy or small molecules. Most pharmaceutical companies shift from in-house platform development to product-specific licensing and co-development to get ON based therapies past clinical trials. Therefore there is a growing and currently unmet need for a combined academic and industry-based multidisciplinary research to further advance the field by bringing together the separated and fragmented R&D efforts of diverse ON technologies. OLIGOMED will address these needs by: - uniting world-class academic and private sector expertise in ON chemistry, bio-analysis and medical applications - developing a next generation ON platform technology based on combining tailored synthetic ONs with smart delivery - optimising ON therapies through testing in medicinal environments We will use these novel ON technologies to develop innovative treatment options for high-impact genetic diseases, i.e. Huntington’s disease, cardiovascular diseases and cancer. Our European intersectoral and multidisciplinary research and training network for 15 Early Stage Researchers (ESRs) will deliver: -highly skilled scientific staff required to fully exploit ON therapeutics for personalised medicine -top-class training in organic and chemoenzymatic synthesis, ON analysis, and biomedical/medicinal testing -transferable skills courses, specific industry relevant workshops and public engagement activities This combination makes OLIGOMED a truly exciting programme for ESRs. The platform will immediately benefit to both European citizens and commercial partners. In the long term, OLIGOMED`s flexible platform technology will be taken forward by our private sector and research institutions for exploitation and will thus strengthen the European innovation capacity in the field of ON therapies.

Keywords: dna chemistry,modified nucleotide,on therapy,dna origami,transfection,huntington s disease,cancer,gene analysis,gene silencing,imaging,delivery,chemoenzymatic synthesis,directed evolution
Systems Medicine of Metabolic-Signaling Networks: A New Concept for Breast Cancer Patient Stratification (MESI-STRAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Spain,Germany,Norway,Norway,Belgium,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: New concepts in patient stratification (H2020-SC1-2017-Two-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2023-09-30
Duration (months): 69.0
Total project cost (EUR): 5949963.75
EU funding (EUR): 5949963.75
Participants: 17
Project status: SIGNED

Breast cancer (BC) is a complex disease with high prevalence in the EU. 75% of the tumors are estrogen receptor-positive (ER+), and are treated with endocrine therapies (ET). MESI-STRAT will develop new concepts for knowledge-based stratification of patients into subgroups with different ET resistance mechanisms. We will establish predictive models for (1) patient stratification prior and during ET; (2) recurrence risk assessment when ending ET; (3) marker panel development to guide targeted therapies for ET-resistant patients; (4) novel ET resistance mechanism-based therapy design. The unique collection of matched BC tissue, serum, and >10 years follow-up from the patient organization PATH is essential for the longitudinal analysis of ET resistance and relapse. Our team of oncologists, modelers, bioinformaticians and experimentalists will develop new computational models in combination with network analyses and pharmacogenomics, to integrate multi-omics data and explore metabolic and signaling (MESI) networks driving ET resistance. Metabolite marker panels measured in biological fluids will enable patient stratification, resistance monitoring and clinical decision-making. This is a new concept as BC metabolism is poorly explored for diagnostics and therapy. Upon successful validation in preclinical models, the predictive marker panels and related treatments will be jointly investigated by our clinical and industrial partners in clinical studies. Our 3 SMEs will closely co-develop the research, and directly exploit the MESI-STRAT results. BC accounts for the highest cancer-related health-care costs in the EU. Our stratification concepts will increase cost effectiveness and the patients’ quality of life by (1) avoiding ineffective therapies, (2) marker detection in body fluids without surgical interventions, and (3) reducing clinical trial cohorts by improved stratification. This will accelerate the translation of MESI-STRAT results into medical use.

Keywords: patient stratification,systems bio medicine,breast cancer,cancer metabolism,cancer signaling
Optimal Taxation of Wealth (Wealth-Taxation)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 90138.6
EU funding (EUR): 90138.6
Participants: 1
Project status: CLOSED

There has been a growing concern in public and academia about rising wealth inequality. In his book Capital in the 21st Century, Thomas Piketty has proposed implementing a global progressive “wealth tax” in order to reduce wealth inequality. The book has spurred discussions on wealth inequality and made taxation of wealth a subject of current debate. Wealth can be taxed by different means. While most countries tax income from wealth (capital income tax), some countries have also taxed wealth stock (wealth tax). Given that capital income tax is already used as a means to tax wealth in many countries, what would be the gain in using wealth tax instead or on top of capital income tax? This is one of the main questions that this proposal addresses. Despite the fact that many papers have studied whether it is desirable to tax wealth, the previous literature has been silent about whether capital income or wealth stock should be taxed. This was because most of the previous papers have made the strong assumption that everyone in the economy earns the same rate of return on wealth. Under this assumption, it turns out that capital income and wealth taxes are equivalent. Thus, the previous literature could not provide any rationale for or against using wealth tax instead or on top of capital income tax. The broad objective of this project is to study quantitatively the optimal structure of taxes on wealth and its implications for wealth inequality, economic efficiency, and overall economic welfare by constructing a framework that includes rate of return heterogeneity and other features emphasized to be important in determination of wealth inequality. Wealth taxation is a subject of current debate not only in academia but also in policy circles. This project contributes to this debate by providing a rigorous analysis that enhances understanding of determinants of wealth inequality and the structure of optimal taxes, and providing guidance for government policy.

Keywords: wealth inequality,heterogeneity,capital income tax,wealth tax
Advancing the state of the art of MIMO: the key to the successful evolution of wireless networks (ATOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus,Malaysia,United Kingdom,Sri Lanka,Pakistan,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 904500.0
EU funding (EUR): 904500.0
Participants: 7
Project status: CLOSED

The world is experiencing an explosion in wireless broadband usage and global wireless data traffic is expected to grow at an annual rate of 78% through 2016. Multiple-input multiple-output (MIMO) technologies have been envisioned as a key to the successful deployment of next generation networks, which are challenged by many practical constraints, such as spectrum scarcity and dynamical wireless environments. The ATOM project will set an ambitious research agenda to fully exploit the potentials of MIMO technologies for revolutionizing wireless networks. Particularly the overall objective of ATOM is to accelerate the transfer and deployment of research knowledge between European countries and third-country partners in order to provide a framework of advanced MIMO solutions for realizing green, secure and high data throughput wireless communications. The novelty of this project is four-fold. Firstly the project brings together two advanced MIMO technologies, massive MIMO and cloud radio access networks (C-RAN), where a novel heterogeneous network architecture is proposed to boost network capacity by effectively exploiting the advantages of massive MIMO and C-RAN. Secondly a rigorous algorithm-theoretic framework for maximizing energy efficiency is developed for the proposed heterogeneous architecture, where energy harvesting is realized by applying the novel concept, simultaneous wireless information and power transfer (SWIPT). Thirdly dynamic physical layer conditions in wireless environments are used to develop comprehensive security solutions for implementing keyless secure transmissions as well as key establishment, which will bridge the gap between physical layer security and the conventional cryptography. Finally we will extend the existing wireless network testbed available at the consortium and carry out experimental evaluations for closing the gap between theory and practice.

Keywords: mimo,green communications,wireless communications
YouBeep – InStore mobile shopping and analytics (YouBeep)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Portugal
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-11-01
End date: 2019-09-30
Duration (months): 35.0
Total project cost (EUR): 1814838.75
EU funding (EUR): 1270387.13
Participants: 1
Project status: CLOSED

The main goal of YouBeep project is to allow shoppers to do the checkout of a full shopping cart, pay and leave the store in under a minute, using only a smartphone! To achieve this goal XHOCHWARE has developed a new concept of self-checkout systems, based on mobile technology, able to be implemented in retailers Point of Sale (POS) without the necessity of buying new terminals or any software integration. Furthermore, YouBeep was made to ensure compatibility, ZERO integration effort, support all POS features, get analytics, and ensure security, rapid deployment and low risk/TCO. The main markets will be large supermarkets and fast-moving consumer goods stores (FMCG), but can also be implemented in every kind of retailer around the world. By using this technology every retailer can immediately benefit from mobile shopping and checkout, while still supporting any current or future checkout features like payment options or loyalty schemes. YouBeep focus is to become a worldwide known brand and identified everywhere, as Visa and MasterCard are in card payments nowadays, no matter the store size or the country you are, the service is there available for you. The support of SME instrument Phase 1, was crucial in providing the support needed to create the confidence in the retailers, demonstrating that XHOCHWARE wasn't just a small company, but a company with huge potential, with international support that could bring them extensive value with YouBeep product. The challenge for Europe is to capture the benefits from developing consumer-oriented platforms that require a strong cooperation between the telecom, hardware, software and service industries, to create and master innovative Internet Ecosystems. With YouBeep, Retailers and shoppers will have access to a new concept of checkout based on mobile technology, new architecture model (service) and a unique and patented add-on device that can dramatically change the shopping process.

Keywords: mobile technology,new self checkout system,disruptive retail solution,shopping process
Designing Novel Phonon Valve Device through Ferroic Domain Wall Engineering (PHONON-VALVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-26
End date: 2019-09-25
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

Much of the major technological breakthroughs occurring in the last few decades rely on our enhanced capability to control and manipulate two particles: electrons (both charge and spin) and photons. Achieving a similar degree of control over phonons would be extraordinarily valuable as we will be able to channel thermal energy at will –thus propelling new possibilities for energy management– as well as the development of a completely novel technology for logic, data storage devices and computing mechanisms based on phonons. The goal of this proposal is to design a conceptually new device: a phonon valve, a nanostructured system to control phonon transport at will by an external field. To carry out this idea we propose to use ferroelectric oxide materials as valves, in particular engineering suitable configurations of ferroelectric-ferroelastic domain walls in multilayer nanostructures. If successful, the realization of this project would represent a major qualitative leap forward in an emerging new technology: “Phononics”. Moreover, it will contribute to progress in the field of physics and properties of ferroic domain walls.

Keywords: ferroelectrics,ferroic domain walls,phonon transport,phononics,epitaxial thin films
Multiscale modelling of migration of pollutant particles in rivers (MULTIPIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

River pollution has become a serious environmental problem in the Europe and worldwide as it dramatically affects the freshwater quality and human health. A major source of chemical and physical pollution in rivers is small particles known as fine-grained sediment (FGS). Intensified agricultural practices and the associated increase in soil erosion in Europe has caused a shape increase in the supply of FGS to water streams. Consequently, the water quality in many rivers in Europe have deteriorated and are failing to meet minimum water quality standards. Hence, there is a urgent need to address the river pollution problem through a thorough understanding on how much supplied FGS infiltrates into the river bed and how much is resuspended and migrated at different hydrodynamic conditions, i.e. the dynamics of FGS. MULTIPIR takes an inter-disciplinary approach to tackle this challenge heads-on by combining the extraordinary experience of the researcher in erosion, sand production, hydraulics and computational fluid dynamics (CFD) with the expertise of the supervisor in coupled discrete element methods with CFD (DEM-CFD) and solid-liquid flows. A combined experimental and numerical investigation on the migration of FGS in the river will be performed, from which multiscale models will be developed to predict the infiltration and re-suspension of FGS at the microscopic level and the transport of FGS at different hydraulic conditions at the macroscopic scale. Using the developed model, a river pollution control map will be developed to guide the river managements. It is for the first time that advanced engineering approaches, e.g. DEM-CFD and advanced imaging techniques, are employed to address the challenging environmental problem and to develop a science-based river pollution control strategy that can benefit European citizens and beyond.

Keywords: river pollution,discrete element method,dem cfd,erosion,particle technology
The Role of Antibodies (Ig) and the Respiratory Epithelium in the Prevention of Invasive Meningococcal Infections in Different Age Groups (EpIg Men)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2022-05-02
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Highly invasive meningococcal infections with serogroup W of clonal type cc11 are rapidly increasing and have a high (16-25%) mortality rate. The aim of this project is to investigate why recent isolates are invasive and how different antibodies can protect. Special focus will be on protection of epithelial cells of the wall of the respiratory tract as prevention of infection may be key to protect the public against infection with MenW cc11. Recent clinical isolates of different clinical invasiveness will be subjected to pangenetic analyses to identify virulence factors. The ability of these isolates to infect epithelial cells will be evaluated to compare virulence factors with functional invasiveness. I then will analyse meningococcal-specific antibody levels in serum and saliva in different age groups with increased carriage and/or risk of meningococcal invasive disease. The antibodies will be evaluated for their ability to protect against infection in two different functional assays: prevention of infection of respiratory epithelial cells and the gold standard serum bactericidal assay that predicts the ability to clear invaded meningococci. Finally, epithelial responses to meningococci and modulation of these responses will be investigated. These studies will analyse cytokine and chemokine production, and the production of antibodies by B cells in epithelial-B cell co-cultures. Together, these data will a) help to identify meningococcal virulence factors and the invasiveness of MenW cc11 relative to other isolates, b) identify levels and functional ability of antibodies to protect against infection in groups at increased risk, c) help in defining a novel correlate of protection and d) reveal meningococcal-epithelial interactions. The results will provide insight for vaccine design, vaccination policy and surveillance strategies.

Keywords: infection,meningococcal invasive disease,respiratory epithelium,antibodies
Blockchain-based, 100% automated KYC (Know Your Customer) service (BlockchainKYC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany,Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-02-01
End date: 2020-12-31
Duration (months): 23.0
Total project cost (EUR): 1758750.0
EU funding (EUR): 1231125.0
Participants: 2
Project status: CLOSED

Online identity theft / fraud due to database breaches, phishing or malware is a global issue with huge costs. In the first half of 2017, 1.9 billion records were stolen worldwide – up 164% compared to the last six months of 2016 – costing on average €3.1 million per breach. After these hacks, fraudsters use the stolen data to impersonate their victims online in a few hours. Online businesses try to shield themselves from the use of stolen or fraudulent IDs by requesting documents to their customers to assert if ‘they are who they say they are’. These global routines are known as ‘Know Your Customer’ (KYC) checks and they aim to ensure that businesses enroll and transact only with legitimate customers. The major downsides of KYC are the slow, manual and costly processes (up to 100€ per check) that delay enrolment for up to 12 days, and the ‘hoarding’ of ID proofs in company’s servers, degrading personal data protection in case of a breach. KYC is compulsory for regulated services (e.g. banks) to mitigate fraud, money laundering and financing of terrorism, but non-regulated services, e.g. AirBnB or Uber, also do KYC checks to avoid fraud costs and reputation loss. To address the problem of unauthorized uses of a legitimate ID (and fraud attempts with non-legitimate IDs) while protecting the personal data of end-users, Authenteq is developing a blockchain-based, 100% automated, identity proofing service – Authenteq ID – with biometric user authentication, ideal for online services that need a trusted ID for user enrolling or to validate high-risk transactions. With the rise of e-commerce and mobile payments (CAGR of 15.9% in the 2016-2021 period), a substantial growth can be expected on the millions of online KYC checks performed annually. To access the multibillion business opportunity of solving KYC checks online, our objective is to establish solid evidence of the economic benefits of Authenteq ID, and risk-free, seamless operation in representative KYC routines.

Keywords: know your customer,identity proofing,mobile authentication,blockchain,distributed ledgers,computer vision forensics,electronic id,biometric,online identity