Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantum Secure Networks Partnership (QSNP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Research and Innovation actions
Countries involved: Spain,France,Denmark,Germany,Netherlands,Italy,Austria,Czechia,Portugal,Belgium,Poland,Malta,Greece,Ireland
Call: HORIZON-CL4-QUANTUM-04-SGA - Quantum encryption and future quantum network technologies (SGA) (HORIZON-CL4-2022-QUANTUM-04-SGA, 2022)
Start date: 2023-03-01
End date: 2026-08-31
Duration (months): 42.0
Total project cost (EUR): 24999999.7
EU funding (EUR): 24999999.7
Participants: 49
Project status: SIGNED

The Quantum Secure Networks Partnership (QSNP) project aims at creating a sustainable European ecosystem in quantum cryptography and communication. A majority of its partners, which include world-leading academic groups, research and technology organizations (RTOs), quantum component and system spin-offs, cybersecurity providers, integrators, and telecommunication operators, were members of the European Quantum Flagship projects CIVIQ, UNIQORN and QRANGE. QSNP thus gathers the know-how and expertise from all technology development phases, ranging from innovative designs to development of prototypes for field trials. QSNP is structured around three main Science and Technology (ST) pillars. The first two pillars, “Next Generation Protocols” and “Integration”, focus on frontier research and innovation, led mostly by academic partners and RTOs. The third ST pillar “Use cases and Applications” aims at expanding the industrial and economic impact of QSN technologies and is mostly driven by companies. In order to achieve the specific objectives within each pillar and ensure that know-how transfer and synergy between them are coherent and effective, QSNP has established ST activities corresponding to the three main layers of the technology value chain, “Components and Systems”, “Networks” and “Cryptography and Security”. This framework will allow achieving the ultimate objective of developing quantum communication technology for critical European infrastructures, such as EuroQCI, as well as for the private information and communication technology (ICT) sectors. QSNP will contribute to the European sovereignty in quantum technology for cybersecurity. Additionally, it will generate significant economic benefits to the whole society, including training new generations of scientists and engineers, as well as creating high-tech jobs in the rapidly growing quantum industry.

Keywords: quantum cryptography,quantum secure networks,secure communication,quantum key distribution qkd,protocols beyond qkd
Complexity in Dynamical systems, Algebra, and Geometry (CODAG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Netherlands,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: CLOSED

The overall goal of the project is to study relations between different measures of complexity of dynamical systems, fractal sets, and groups. The main objects of our interest are iterated monodromy groups (IMGs), which are self-similar groups naturally associated to certain dynamical systems, such as the iteration of a rational map on the Riemann sphere. IMGs provide a prominent bridge between dynamical systems and geometric group theory, and their study has been a vibrant topic in the last 20 years. In the project, we will focus on three aspects of this modern research. Subproject A: Decomposition theory of maps and groups In a recent work with collaborators, I established a novel decomposition theorem for rational maps based on the structure of their Julia sets. I aim to extend this result to the case of contracting self-similar groups, which will provide a new entry to the renowned Sullivan dictionary. I will also explore computational aspects of IMGs and implement the decomposition in the computer algebra system GAP. Subproject B: Algebraic properties of IMGs Quite unexpectedly, the IMGs of even very simple maps provide examples of groups with interesting properties that are “exotic” from the point of view of classical group theory. However, we still lack general theory that will unify these nice examples. The main objective in this research direction is to relate dynamical properties of maps to algebraic properties, such as growth and amenability, of the respective IMGs. Subproject C: Spectral properties of Schreier graphs of IMG The study of the Laplacian spectrum and spectral measures occupies a significant place in the geometric group theory. Computations of spectra for the Schreier graphs of self-similar groups have recently been an active filed of research. Surprisingly, it connects to multidimensional dynamics and Schroedinger operators associated to aperiodic order. The goal of this subproject is to explore such connections in the case of IMGs.

Keywords: dynamical systems,iteration of rational maps,self similar groups,iterated monodromy groups,growth,amenability,spectral theory,schreier graphs
Multi-messenger Studies of Extragalactic Super-colliders (MuSES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2799989.0
EU funding (EUR): 2799989.0
Participants: 1
Project status: SIGNED

Active galactic nuclei (AGN) are among the most powerful particle accelerators in the Universe. They convert the gravitational energy of matter accreted by supermassive black holes (SMBHs) into electromagnetic and kinetic energy, producing highly relativistic electrons and protons. They are most likely originated from the vicinity of SMBHs, but the exact mechanism of their production remains elusive. Electrons are predominantly found in jets, whose acceleration and collimation are still poorly understood. Even less clear is how and where protons are accelerated and how this process is connected to neutrino production. The importance of investigating such high-energy particles transcends astrophysics, as they probe regimes that particle accelerators on Earth will likely never reach. The recent detection of a high-energy neutrino signal from the blazar TXS 0506+056 by the IceCube Neutrino Observatory has brought up new multi-messenger opportunities for AGN studies which can be now most efficiently explored. This proposal sets its main aim on carrying out such an exploration and addressing the pivotal questions about proton acceleration, jet formation and collimation, and neutrino production in AGN. To achieve these goals, we will perform and utilize observations of AGN across the electromagnetic spectrum, with a particular focus on high-resolution very-long-baseline interferometry and data collected by high-energy neutrino telescopes. The information and insight gathered through these investigations will provide the most accurate clues about the extreme energy output in AGN and transform these objects into well-understood cosmic laboratories which can probe physical conditions unachievable in any experiments performed on Earth.

Keywords: multi messanger astronomy,high energy neutrino,agn,blazars,vlbi,radio astronomy
Exploiting ex vivo expansion and deep multiomics profiling to bring novel, efficient and safer hematopoietic stem cell gene therapies to clinical application (X-PAND)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Spain,Germany,Switzerland
Call: Emerging Technologies in Cell and Gene therapy (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 3797562.5
EU funding (EUR): 3797562.5
Participants: 7
Project status: SIGNED

Hematopoietic stem cells (HSC) are an elusive cell type, whose presence can only be inferred retrospectively, from the outcome of time-consuming transplantation experiments. Since current state-of-the-art does not allow prospective HSC identification, today’s cell and gene therapy technology has been mostly optimized on surrogate progenitor cells, which differ biologically from HSC. The technological breakthrough of this proposal is to capture HSC in the ex vivo culture, achieved by a combination of innovative expansion conditions, iterative cell sorting and multiomics single cell profiling. Rapid, quantitative and qualitative in vitro HSC assessment predictive of in vivo function may become a sustainable alternative to mouse xenotransplantation experiments. Applied to a state-of-the-art toolbox of genetic engineering technologies including clinically-proven lentiviral vectors as well as established and emerging targeted genome editing approaches, our in vitro HSC readout sets new standards in terms of throughput and turnaround time, allowing to efficiently test a multitude of HSC engineering conditions and tailor the most suitable technological approach to a specific disease or therapeutic application. This new precision-based approach to ex vivo HSC gene therapy will be applied to inherited bone marrow failure syndromes and cancer as paradigmatic examples where gene therapy may be used to correct a cell-intrinsic genetic defect or turn hematopoietic progeny into therapeutic vehicles provided with novel functions. Bringing together experts in cutting-edge gene editing technologies, ex vivo HSC manipulation, assessment of HSC responses to genetic engineering and bioinformatics analysis & integration of multi-dimensional single cell data will maximize the chances of delivering safer and more effective next-generation HSC-based gene therapy products, extending the reach of gene therapy to new disease contexts and making the outcome after gene therapy more predictable.

Keywords: gene editing,base editing,lentivirus,ex vivo hsc expansion,immuno oncology,cancer immunotherapy,bone marrow failure syndromes,single cell technologies,multiomics,genotoxicity,senescence
Dimension Theory of Stationary Fractal Measures (DIM-FRACTAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

We consider the dimension of stationary fractal measures. Our examples include self-affine, self-similar, and Furstenberg measures, which are among the most fundamental and studied fractal objects. The dimension of such a measure has a natural upper bound defined in terms of entropy, Lyapunov exponents, and the dimension of the ambient space. Equality to the upper bound is expected in the absence of obvious algebraic obstructions. In very simple situations, this equality is easy to demonstrate and was known to hold long ago. In more complicated cases, it has been shown to hold almost surely under a natural randomization of the parameters. On the other hand, proving the expected equality under the minimal conjectured assumptions, or even under some mild algebraic conditions, is an extremely challenging problem. In recent years, there has been considerable progress in this direction. However, due to major obstacles in current methods, a satisfactory solution is still a long way off. These obstacles mainly stem from high dimensionality of the ambient space, and from lack of separation in the associated semigroup. The primary goal of the proposed research is to make substantial progress in verifying the equality by addressing the aforementioned obstacles through the use of new techniques and ideas. Our suggested arguments include methods from additive combinatorics, ergodic theory, and the theory of random products of matrices. To address difficulties caused by lack of separation, we suggest extending the theory developed for Bernoulli convolutions, and its partial generalization to the setup of three maps, to systems consisting of more maps. To tackle high dimensionality difficulties, we propose an approach requiring the factorization of the Furstenberg boundary maps. By implementing these strategies, we expect our research to play a crucial role in forming a more unified and complete dimension theory of stationary fractal measures.

Keywords: dimension of measures,lyapunov dimension,self similar measure,self affine measure,furstenberg measure
Sustainable Transition to the Agile and Green Enterprise (STAGE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Coordination and support actions
Countries involved: Greece,Lithuania,Bulgaria,Poland,Slovakia,Germany,Italy,Slovenia,Ireland,Norway,Spain,United Kingdom
Call: 'Innovate to transform' support for SME's sustainability transition (CSA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2025-09-30
Duration (months): 40.0
Total project cost (EUR): 4691490.0
EU funding (EUR): 4691490.0
Participants: 18
Project status: SIGNED

Sustainability and the transition to a low-carbon, more resource-efficient and circular economy are key in ensuring the long-term competitiveness of the European Union (EU) economy. Sustainability has long been at the heart of the European Union project and the EU Treaties give recognition to its social and environmental dimensions. Advanced industrial technologies are at the heart of the Industrial Revolution, shaping the future of production and value chains. It opens opportunities for companies to shape a new wave of economic growth. More than 75 percent of European Industrial SMEs indicate that the main barrier for the implementation of Advanced Technologies is the lack of financial resources and access to considerable investment opportunities. The STAGE project will create the sustainability transition ecosystem, train Sustainability Advisors and provide high-quality innovation and sustainability assessment, decentralised training courses and innovation support and sustainability transition services to more than 2000 European industrial SMEs during the project duration, transforming them into the agile and green enterprises, competitive and sustainable leaders of the European industrial economy. STAGE will achieve the Grant Amount Multiplier of 100x with Private Finance during the project.

Keywords: sustainable transition,sustainability advisors,decentralised training courses,training the trainers,access to finance,private investing
NaturaConnect - Designing a resilient and coherent Trans-European Network for Nature and People (NaturaConnect)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Austria,Germany,Italy,Netherlands,Portugal,Spain,Finland,France,Belgium,Hungary,Romania,Poland,United Kingdom
Call: Supporting the development of a coherent and resilient Trans-European Nature Network (HORIZON-CL6-2021-BIODIV-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 9709202.75
EU funding (EUR): 9709202.75
Participants: 22
Project status: SIGNED

Together with key stakeholders, NaturaConnect will co-develop knowledge, tools and capacity building programmes to support Member States in implementing an ecologically representative, resilient and well-connected trans-European nature network (TEN-N) that builds on the existing network of protected areas and Green and Blue Infrastructure. Through research, engagement and dissemination activities at the European scale and in a set of six case studies, we will elicit stakeholders’ visions and preferences about conservation objectives, tap into best practices in protected areas management and funding mechanisms, mobilize data and test the TEN-N spatial prioritization analyses and tools produced by NaturaConnect. This addresses two major obstacles identified by the EU Nature Legislation Fitness Check: lack of stakeholder awareness and cooperation, and insufficient knowledge and access to existing funding mechanisms. NaturaConnect will further address a third major obstacle, limited availability of knowledge on biodiversity distribution, drivers of change and conservation solutions. To address this, NaturaConnect brings together a consortium of the top European scientists, policy experts and NGOs to produce and mobilize relevant data and knowledge. This includes refining and applying state-of-the-art models on biodiversity, ecosystem services and environmental change across Europe and under current and future climate and land-use. Equipped with improved data, knowledge, models and spatial planning methods we will identify gaps in protected area coverage, connectivity and resilience under climate and land-use change. We will further develop scenarios for expanding protected areas, establish ecological corridors and other areas of connectivity to address these gaps, thereby offering a blue-print for realizing TEN-N. NaturaConnect will further provide knowledge and decision support for policy, financing and implementation of TEN-N at all relevant scales.

Keywords: green infrastructure,trans european nature network,eu biodiversity strategy,spatial planning
Independent mobility to the blind and visually impaired using wearable remote touch sensing technology (7Sense)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2025-01-31
Duration (months): 28.0
Total project cost (EUR): 3194181.25
EU funding (EUR): 2235926.88
Participants: 1
Project status: CLOSED

7Sense™ is a unique innovation that can empower 290 Million blind and visually impaired people to safely achieve independent mobility in indoor and outdoor spaces, and to interact with the surrounding environment and people – no remote or physical assistance, no dog, no cane. 7Sense gives a superhuman sense of touch, enabling them to see and be free. The patented technology comes in the form of a wearable headband comprising a proprietary haptic device (array of physical pixels) and a 3D capture camera. 7Sense captures the physical world in real-time and conveys it to the users’ forehead through the sense of touch. The prototype (TRL6) has already collected positive feedback from the Chairman of the Estonian Blind Union who lost complete sight at age 13 – ‘For once I was blind, now I can see. This changes everything’. The company has the technical know-how, strategic alliances, and management and business experience to create and deliver the solution effectively and at scale.

Keywords: immersive technology,remote touch sensing,tactile,blind,visually impaired,assistive technology
A Novel Glutamine (Q) Sensory Role for Primary Cilia: Implications for Health and Disease (QtCilia)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Primary cilia are single, microtubule-based, organelles protruding as antennae at the surface of most cells. Their dysfunction is associated with several genetic disorders, called the ciliopathies. We recently identified a new, previously undescribed, role for primary cilia as sensors of cellular nutrient availability. In this novel mTORC1-independent pathway, cilia directly communicate with mitochondria to drive metabolic reprogramming under nutrient stress, when glutamine (Q) becomes an obligated carbon source. Here, we will tackle two fundamental questions: i. why mammalian cells “taste” the extracellular milieu via a sensory monocilium, and how is the resulting information conveyed to mitochondria? ii. what are the consequences when the cross-communication is impaired? While our newly identified cilia pathway is relevant in multiple cell types, here we focus on renal epithelia, because the kidney is severely affected in the ciliopathies and because we contributed defining the crucial role of metabolic balancing in this organ. The goals are: 1) to identify the precise mechanism(s) underlying the ciliary response to nutrients; 2) to test the hypothesis that primary cilia directly cross-communicate with mitochondria via protein exchange; 3) to define the relevance of this pathway for the pathogenesis and treatment of ciliopathies. We will use newly developed methods and combine high-throughput with hypothesis-driven approaches in a broad program designed to balance high-risk/high-gain with low-risk/high-gain tasks. The project has two inherent souls: one devoted to the understanding of a novel, very basic biological process; the second to the translation of novel basic concepts to decipher disease pathophysiology. QtCilia (Q tasting Cilia) benefits from a unique across-disciplines background and expertise of the PI, who positions herself strategically to make paradigm-changing discoveries, for which exceptional resources via innovative funding schemes are sought.

Keywords: cilia,mitochondria,glutamine anaplerosis,metabolic stress,metabolic reprogramming,polycystic kidney disease,genetic diseases of the kidney,inborn errors of metabolism,metabolic reprogramming in cancer