Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing Fan Engagement For Increasing Participation, Attendance and Commercial Value in Women's Football (FEDev-WF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-11
End date: 2023-10-10
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: SIGNED

European women’s football has come a long way in recent years, yet it is still considerably underdeveloped. Football being one of the most revered forms of popular culture in Europe offers a unique window into evolution of roles and representation of achievements of women, but despite significant strides in recent years the women’s game is still far behind. Fewer sponsorship deals, lower stadium attendance and commercial value were a few of the problems with which women’s football struggled, even before the Covid-19 outbreak. Now, the sustainable survival of the game is under threat. In both industry and academia there is a gap in attention to women’s football fandom, particularly from the organisations’ side, and its potentials for commercial value creation and financial sustainability of the game. Taking the high potential of fandom to generate sustainable income, the present project aims to develop fan engagement practice to increase attendance and commercial value in women’s football. I will employ a novel interdisciplinary, comparative participatory approach involving academia and industry stakeholders, identifying the unique attributes and current state of women’s football fandom and key components of an effective fan engagement framework for teams and associations. The project will be conducted in the context of Ireland and will be hosted by Dublin City University. To learn about fan engaging planning, practices and data analysis in the industry, I will carry out two secondments in two well-known sport marketing companies in Europe. Collectively, the outcomes of this project will provide a novel understanding of gendered perceptions of women’s football in Ireland and Europe, and how fan engagement can be tailored to women’s football for better commercialisation. The findings would help the industry engage fans effectively for the survival of the game, and future research can build up on the ideas and findings in different countries and women’s sports.

Keywords: fan engagement,women s football,commercial value,participatory research
UNWRAPPING THE BIOECONOMY POTENTIAL (CroBio2020)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Coordination and support actions
Countries involved: Croatia
Call: Bioeconomy Presidency Conference (H2020-IBA-SC2-Bioeconomy-2019-15, 2019)
Start date: 2020-04-01
End date: 2020-09-30
Duration (months): 6.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The bioeconomy covers all sectors and systems that rely on biological resources, their functions and principles all primary production sectors that use and produce biological resources (agriculture, forestry, fisheries and aquaculture) and all economic and industrial sectors that use biological resources and processes to produce food, feed, bio-based products, energy and services. Today’s bioeconomy is considered a central element to the functioning and success of the EU economy. In 2015, it contributed an estimated €2.3 trillion turnover, €621 billion value addition and employed 18 million people. Croatia’s has a good potential to transitioning into a sustainable circular bioeconomy given its abundant land and marine natural resources. Croatia is now in the process of developing it National Bioeconomy Strategy and Action Plan. At the regional level, Croatia is also an active member of the BioEast Network working joint with other member countries on pursuing a common strategic bioeconomy agenda and partnerships in key priority areas. At the EU level currently strategical linkages to the National Agricultural and Rural Development Plan and the Post 2020 CAP are been identified. Furthermore, emerging EU initiatives such as the New Green Deal need to be discussed and evaluated to identify potential contributions of agriculture and particularly bioeconomy to this new approach. A more strategic and comprehensive engagement national, regionally and international is paramount to inform the evolution of the bioeconomy sector in Croatia. The objective of the EU strategy for the bioeconomy of 2012 Is way to a more innovative and competitive society, in which. Better Masters of resources and in which food security can be aligned with sustainable use of renewable resources for industrial needs while ensuring environmental protection ". The Commission is 2017. Revised EU strategy for the bioeconomy of 2012. and concluded that the relevance of the strategy's objectives has been

Keywords: croatia bioeconomy conference
Linking Transcription Factor Binding Dynamics to Promoter Output (DynaMech)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-02-01
End date: 2021-01-31
Duration (months): 60.0
Total project cost (EUR): 2132500.0
EU funding (EUR): 2132500.0
Participants: 1
Project status: CLOSED

Transcription is a stepwise process that is inherently dynamic. Different types of transcription factors are continuously interacting off and onto DNA, "searching" for appropriate interactions - each bringing different functions into play. The rates with which these factors interact with chromatin, their association and dissociation rates, dictate the outcome of "steady-state", developmental and rapidly responsive regulatory programs. Given the central role of transcription factors in biology and disease, it is remarkable that we know next to nothing about the dynamics of transcription factor-chromatin interactions. The objective of DynaMech is to implement technologies that will allow us to measure transcription factor binding dynamics (on- and off-rates) genome-wide, at binding site resolution. This will be applied to gain a systematic understanding of how these dynamics effect the function of transcription factors. Analyses will encompass components of the RNA polymerase II pre-initiation complex in yeast, as well as a comprehensive set of gene-specific transcription factors. For each of these factors we will determine the on- and off-rates genome-wide as well as the degree to which the mRNA synthesis rates from all promoters are dependent on the factor. This data will all be analysed in the context of nucleosome binding dynamics to understand the general principles of how chromatin-transcripton factor binding dynamics shape regulatory mechanisms. Through modelling promoter output and by additional perturbations, these principles will be explored to understand which properties of regulatory DNA determine differential transcription factor dynamics thereby causing differential promoter behaviour. We are as yet far from predicting regulatory outcome from regulatory sequence. The long-term aim of this work is to bring this closer, by bringing into play the almost completely unexplored aspect of transcription factor-chromatin interaction dynamics.

Keywords: mechanisms of transcription regulation,yeast,saccharomyces cerevisiae
Ground-breaking retractable ship bow foils for unbeatable cost-saving, emission reduction and motion stabilization (SmartWings)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Norway
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-09-01
End date: 2023-12-31
Duration (months): 40.0
Total project cost (EUR): 3014417.5
EU funding (EUR): 2110092.25
Participants: 1
Project status: SUSPENDED

Medium-size ships navigating in waves suffer up to 100% higher resistance than in calm water. This added resistance has several consequences: 1) dramatic speed loss, 2) increase of fuel consumption and CO2 emissions, and 3) dangerous roll (side to side) and pitch (up and down) movement that causes seasickness and decreases crew productivity. Adding wings or foils to a ship bow can use wave energy to propel the ship forward and damp roll and pitch motions, stabilizing the ship. However, navigating with bow foils is counterproductive in certain situations, such as in calm or extreme weather, where the foils increase the ship resistance. A retraction and storage mechanism for the foils in these situations is desired, but until now no practical solution had been developed for bow foils retraction. We, at Wavefoil, have developed the first ever retractable bow foils. Combining the use of strong and flexible composite materials with an innovative and patent-pending vertical retraction mechanism, we have developed the first and only retractable bow foil modules that fit the narrow bow of any vessel. Our bow foils: 1) reduce the energy consumed to propel the ship by 5-20%, 2) reduce pitch and roll motion, promoting a more comfortable and productive trip, 3) can be retracted/deployed to optimize the ship performance for any given situation. Our unique foil retraction system allows, for the first time ever, to exploit the full range of benefits of bow foils. The SmartWings project aims to mature and bring to market a unique solution for ship stabilization and forward thrust for medium-size ships. The retractable foils will become our gold-standard product and will boost Wavefoil growth, generating €75m profits and 26 new job positions by 2027. In this time, commercialization will save 1,097k tonnes of CO2(eq) emissions and €179m for global shipping. Zero-emission ships are facilitated as they will need less reserve battery capacity to traverse rough seas.

Keywords: co2 emissions,ghg emissions,ship stability,zero emission shipping,carbon based fuel savings,ship foils,rolling,pitching,ship forward thrust,wave propulsion,wave energy,retractable foils
Inhibiting Misfolded protein PRopagation in Neurodegenerative Diseases - Sofia ref.: 116060 (IMPRiND)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Germany,Switzerland,Belgium,Belgium,Greece,Switzerland,France,France,France,Denmark,United Kingdom,United Kingdom,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: IDENTIFICATION OF DRUGGABLE TARGETS MODULATING MISFOLDED PROTEINS IN ALZHEIMER’S AND PARKINSON’S DISEASES (H2020-JTI-IMI2-2015-07-two-stage, 2015)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 11388398.0
EU funding (EUR): 4684998.0
Participants: 21
Project status: CLOSED

Assemblies of tau and α-synuclein were shown to spread along interconnected neuronal networks suggesting broadly relevant therapeutic directions for Alzheimer’s and Parkinson’s disease. This requires a pre-clinical stage of development that has yet to be met. The scale of neurodegenerative disease burden in Europe calls for an unprecedented research effort that can only be achieved through collaboration between leading European laboratories and the pharmaceutical industry. To meet this ambition the IMPRiND consortium will synergistically accelerate progress to map and target critical steps in the propagation, proteostatic response and protection against misfolded α-synuclein and tau. Specifically we aim to (1) identify disease-relevant assemblies, imprint their biological properties in vitro and generate homogeneous populations to assay and interfere with their pathogenic effects; (2) develop and miniaturise assays to monitor secretion, uptake, clearance and oligomerisation using bimolecular fluorescence complementation of oligomeric species or transfer of untagged assemblies to fluorescently labelled fibril-naïve cells and measure markers of early proteotoxicity that are suitable for live imaging high content screens; (3) deliver robust validation assays for these molecular events in complex cellular systems with greater functional resemblance to the native milieu of the brain such as iPSC-based and organotypic cultures (4) standardise pathological readouts in animal models for in vivo validation of modifiers, correlate them with novel peripheral or in situ markers using microdialysis to accelerate the assessment of therapeutic interventions and relevance to humans, e.g. by transplantation of human iPSC neurons in animals; (5) assess toxicity and druggability of potential targets. IMPRiND will construct this entire pipeline to examine the prion-like properties of α-synuclein and tau and test their tractability against disease progression.

Keywords: aggregation,propagation,neurodegeneration,druggable targets
Novel multivariate, high-resolution mapping of the exposure of ecosystems to climate and land use change (CLIMLAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

To protect and preserve natural habitats, we urgently need integrated assessment methodologies. Current conservation-oriented assessments of ecological vulnerability rely upon the identification and quantification of the effects from of the most important drivers of change. However, accurate predictions and practical solutions have proved difficult to formulate as most works at global or continental scales have only focused on climatic changes, disregarding important factors such as land use change. CLIMLAN will address this shortcoming using an integrated assessment that combines two of the most important drivers of biodiversity change today: climate and land-use change. Here I will answer two original and important questions: (1) which are the most useful indices for measuring and mapping the ecological vulnerability to future environmental change?; and (2) is there a mismatch between current management and planning strategies and ecological vulnerability to projected environmental changes? For this, I will focus on measuring and mapping both climate and land use changes over time, and assessing how such changes match both ecosystem vulnerability and current conservation practices. A lasting product of CLIMLAN will be a readily applicable open access spatially explicit methodology and an online mapping tool, to measure and spatially display ecosystem vulnerability to environmental changes. These tools will allow a better assessment of the current and expected effects of changing environmental conditions on conservation areas, and will facilitate targeted management guidelines and improved adaptation strategies.

Keywords: ecological responses,environmental change,exposure,sensitivity,vulnerability
Reversible solid oxide Electrolyzer and Fuel cell for optimized Local Energy miX (REFLEX)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Spain,Italy,Italy,Estonia,Finland,France,France,France,Denmark
Call: Reversible Solid Oxide Electrolyser (rSOC) for resilient energy systems (H2020-JTI-FCH-2017-1, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 2999575.48
EU funding (EUR): 2999575.25
Participants: 10
Project status: SIGNED

The REFLEX project aims at developing an innovative renewable energies storage solution, the “Smart Energy Hub”, based on reversible Solid Oxide Cell (rSOC) technology, that is to say able to operate either in electrolysis mode (SOEC) to store excess electricity to produce H2, or in fuel cell mode (SOFC) when energy needs exceed local production, to produce electricity and heat again from H2 or any other fuel locally available. The challenging issue of achieving concomitantly high efficiency, high flexibility in operation and cost optimum is duly addressed through improvements of rSOC components (cells, stacks, power electronics, heat exchangers) and system, and the definition of advanced operation strategies. The specifications, detailed system design and the advanced operation strategies are supported by modelling tasks. An in-field demonstration will be performed in a technological park, where the Smart Energy Hub will be coupled to local solar and mini-hydro renewable sources and will provide electricity and heat to the headquarters of the park. It will demonstrate, in a real environment, the high power-to-power round-trip efficiency of this technology and its flexibility in dynamic operation, thus moving the technology from Technology Readiness Level (TRL) 3 to 6. The Smart Energy Hub being modular, made of multistacks/multimodules arrangements, scale up studies will be performed to evaluate the techno-economic performance of the technology to address different scales of products for different markets. To reach these objectives, REFLEX is a cross multidisciplinary consortium gathering 9 organisations from 6 member states (France, Italy, Denmark, Estonia, Spain, Finland). The partnership covers all competences necessary: cells and stacks development and testing (ELCOGEN, CEA, DTU), power electronics (USE, GPTech), system design and manufacturing (SYLFEN), system modelling (VTT), field test (Envipark), techno-economical and market analysis (ENGIE).
EU-China study on IoT and 5G (EXCITING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: China,Switzerland,Switzerland,France,France,France,United Kingdom,Luxembourg,Portugal
Call: CHINA: Collaboration on Future Internet (H2020-ICT-2016-INT, 2016)
Start date: 2016-11-01
End date: 2019-01-31
Duration (months): 27.0
Total project cost (EUR): 2533672.5
EU funding (EUR): 999547.5
Participants: 16
Project status: CLOSED

Europe and China are at the forefront of technological advances in areas related to the Future Internet (especially 5G and IoT). While both parties share common technological objectives, there is still room for improvement in what concerns bilateral co-operation. As a result, the main purpose of EXCITING is to support the creation of favourable conditions for co-operation between the European and Chinese research and innovation ecosystems, mainly related to the key strategic domains of IoT and 5G. EXCITING will study the research and innovation ecosystem for IoT and 5G in China and compare it with the European model. EXCITING will identify and document the key international standards bodies for IoT and 5G, as well as other associations and fora where discussions take place and implementation decisions are made. Going beyond standardisation, interoperability testing is a key step towards market deployment. EXCITING will identify and document the key international InterOp events at which European and Chinese manufacturers can test and certify their IoT and 5G products. It will also explain the rules for engaging in these events. EXCITING will produce Best Practice guidelines for establishing and operating practical joint collaborations, in order to stimulate further such co-operations in the future on IoT and 5G Large Scale Pilots. As a result of the above investigations EXCITING will produce a roadmap showing how research and innovation ecosystems, policy, standardisation, interoperability testing and practical Large Scale Pilots should be addressed during the H2020 timeframe, and make recommendations for optimising collaboration between Europe and China for IoT and 5G.

Keywords: 5g large scale pilots,roadmap,future internet
Moving a novel gene therapy paradigm to treat blindness to the market (inSight)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy,Italy
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 107625.0
Participants: 2
Project status: CLOSED

At present therapies for inherited dominant disorders are not available, thus representing an urgent unmet medical and social need. The ERC Grant ALLELECHOKER enabled the PI to discover three modes to generate transcriptional repression by transcription factors (TFs) based on Zinc-finger scaffold: i- synthetic transcription factor (TF; Mussolino et al., EMBO Mol. Med. 2011 Mar;3(3):118-28; Botta S. et al. Elife. 2016 Mar 14;5), ii- synthetic DNA-binding protein (Botta S. et al. Elife. 2016 Mar 14;5) and iii- the ectopic expression of an endogenous TF (Botta S, et al. JCI Insight. 2017 Dec 21;2(24). Thus, the PI demonstrated that transcriptional repression by TFs embodies a novel therapeutically effective mode to treat the toxic effects of gain-of-function mutations causing incurable inherited dominant disorders. In particular, mutations in the RHODOPSIN gene can cause the blindness disorder autosomal dominant retinitis pigmentosa (adRP). The PI demonstrated safety and efficiency of RHODOPSIN gene transcriptional silencing in pre-clinical animal models by a specific synthetic transcriptional repressor (ZF6-DB) delivered to the retina by an adeno-associated virus (AAV) vector (AAV-ZF6-DB). Furthermore, within the ERC Grant ALLELECHOKER the PI showed that a single AAV vector containing two independent expression cassettes (AAV-ZF6-DB-hRHO), enables balanced silencing of RHODOPSIN by ZF6-DB and its simultaneous replacement with a human wild-type copy of the RHODOPSIN gene. The primary objective of the inSight ERC-PoC grant is to support AAV-ZF6-DB-hRHO clinical translation, with the final goal of bringing this therapeutic to patients suffering adRP through market authorization and commercialization.

Keywords: adeno associated virus aav vector,retina,gene therapy,gain of function,orphan disease