Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mapping inequalities through the life course (MapIneq)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Finland,Germany,Estonia,Spain,Sweden,United Kingdom,Netherlands
Call: Determining key drivers of inequality trends (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-10-01
End date: 2025-12-31
Duration (months): 39.0
Total project cost (EUR): 3305295.0
EU funding (EUR): 3305295.0
Participants: 8
Project status: SIGNED

The MapIneq project studies the trends and drivers of intergenerational, educational, labour market and health inequalities over the life course during the last decades. Our main driving research questions are: 1. How do local and national opportunity structures enhance, suppress or mediate inequalities? 2. How do changes and spillovers across the life domains and over life course contribute to inequalities? 3. How are inequalities influenced by policies and societal shocks? Opportunity structures refer to social institutions, demographic and macroeconomic conditions and socio-environmental context, which we analyse across countries, regions and localities. We focus on societal changes influencing inequalities, including those related to family diversity and complexity, fertility, migration and population ageing, digitalization, the 2007-08 global financial crisis and how the covid-19 pandemic revealed and exacerbated inequalities. We compile a policy database of the educational, family, labour market, social benefits and tax-related policies, matched with subnational-level information on social and institutional structures and physical environments. This results in an easy-to-use, open access MapIneq product which consists of visualization and mapping tools, all underlying data, statistical programming tools, and open-access code. We link the information in the database to individual-level longitudinal and cross-country datasets to study the dynamic interplay between the spheres of life. This research is conducted under life-course stage specific work packages: Inequalities in the early childhood and families, Educational inequalities, Inequalities in school-to-work transitions, Unequal mid-career trajectories and Labour market exits. We consider how the covered societal changes are linked with the perceptions on inequalities across and within countries. We co-create solutions through discussion fora for stakeholder groups across multiple levels of governance.

Keywords: life course,social inequality,spillovers,opportunity structures,early childhood,education,labour market,families,policies,intergenerational processes,subnational differences,income,health
Translating Institutional Systems (TRAILS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 242116.8
EU funding (EUR): 242116.8
Participants: 1
Project status: SIGNED

The nature of cognition in real-life work settings has attracted the interest of scholars from different academic disciplines in the last decades. However, a professional activity that so far has received limited attention in research, despite its potential to produce considerable insight into the nature of cognition in large-scale organisations, is translation work in institutional settings. Institutional translation, e.g., in the European Union institutions, is characterized not only by institutional norms and regulations which are transferred across actors, artifacts, and time, but also by the ubiquitous use of technology. As such, it appears particularly well-suited for advancing the current knowledge of how cognitive processes, such as knowledge, remembering, and decision making, are distributed across actors in teams in institutional settings, as well as through their interactions with technology. This project aims to explore and model distributed cognitive processes by investigating social interaction and human-technology interaction in institutional translation settings, thus pushing the boundaries of current conceptualizations of distributed cognition in institutions. Ultimately, the study will result in the development of a theoretical model of distributed cognition in institutional translation settings that will inform future research into socio-cognitive aspects of cognition, interaction, and cross-linguistic communication. These research objectives will be pursued through the interdisciplinary integration of theoretical insights and methodologies from cognitive science, linguistics, anthropology, and translation studies. Specifically, it will combine ethnographic fieldwork with micro-ethnographic multi-modal interaction analysis to gather data on team interactions in the EU institutions, primarily by means of video recordings, but also with other types of discursive, naturally occurring data, such as documents produced and used in the institutions.

Keywords: institutional translation,distributed cognition,social interaction,workplace communication,cognitive artifacts
Element-selective impulsive electronic and vibrational spectroscopy of iron-sulfur clusters (METRICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 217309.2
EU funding (EUR): 217309.2
Participants: 3
Project status: SIGNED

The catalytic activity of metalloproteins and cofactors is at the heart of biological systems’ functioning. Biological reactions occur under physiological conditions in stunning contrast with the extreme temperatures and pressures demanded by industrial processes. The evolutionary “optimal design” of enzymatic reactions led to the ubiquitous presence of key molecular motifs in several metabolic pathways, among which the iron-sulfur (FeS) clusters. Understanding how these multimetallic clusters act in Nature requires mapping their electronic and structural configuration, a challenging task that calls for new investigation methods. In this project, the main issues of conventional spectroscopies for the characterization of FeS clusters are circumvented harnessing the potential of novel atto- and femtosecond sources, implementing element-selective impulsive vibrational spectroscopy (ES-IVS) and element-selective impulsive electronic spectroscopy (ES-IES). The impulsive excitation of FeS clusters with few-cycle pumps in the nearinfrared (for ES-IVS) and visible (for ES-IES) spectral ranges triggers their vibrational and electronic wavepacket dynamics, respectively. Using ultrashort soft X-ray pulses, the clusters’ time-domain response is monitored with element selectivity at the Fe M2,3-edge and S L2,3-edge, retrieving characteristic oscillation frequencies upon Fourier transform of the time traces. ES-IVS will provide direct structural information of FeS clusters measuring Fe and S low-frequency vibrational spectra inaccessible with other approaches. ES-IES will map the Fe electronic states that are at the hearth of FeS catalytic activity and whose experimental observation has proven impractical. This project will establish these techniques as advanced X-ray spectroscopic tools for the investigation of FeS clusters, providing a better understanding of their role in crucial biological processes such as oxidative phosphorylation, photosynthesis and nitrogen fixation.

Keywords: pump probe spectroscopy,impulsive vibrational spectroscopy ivs,attosecond transient absorption spectroscopy atas,x ray absorption spectroscopy xas,iron sulfur clusters
Investigate the mode of action ofInvestigate the mode of action of beta-carboline derivative Harmine on increasing MHC-I expression and potentiating the Immune Checkpoint Blockade cancer immunotherapy (INCEPTOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Luxembourg
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

One of the major mechanisms by which solid tumors escape anti-tumor immunity is the downregulation of major histocompatibility complex class I (MHC-I), which causes a failure in the recognition of tumor cells by the cytotoxicity T-cells. The project proposed by Dr. Teresa Ramos contains basic and translational aspects. The basic aspect relies on investigating the mechanisms of action of the ACB1801 molecule (harmine), reported by the host team to restore the MHC-I in tumor cells, using state-of-the-art technologies. The translational aspect of the project relies on providing the preclinical proof of concept for an innovative immunotherapy combination. The combination strategy consists of using a vaccination approach with Dendritic Cells (DC), pulsed with tumor cells pre-treated with ACB1801, in combination with immune checkpoint blockades. Although DC vaccination constitutes potent anticancer immunotherapy, clinical data showed that it does not provide robust benefits to patients. the innovative strategy of the project is based on simultaneous boosting the DC-based vaccine by ACB1801 and unleashing the power of T cells to induce a robust anti-tumor immune response which constitutes an unmet clinical need. The development of the present proposal will enable Dr. Ramos to achieve a broad range of new technologies and management skills through a variety of multidisciplinary training programs. This will represent a key step toward her final objective to become an independent and competitive scientist.

Keywords: carboline harmine,acb1801,mhc i,dendritic vaccine,immune checkpoint blockade,pd 1,melanoma,colon carcinoma
Exploring Mammoth Bone Accumulations In Central Europe (MAMBA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Poland,Czechia,Sweden,United Kingdom,Germany,Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1992304.0
EU funding (EUR): 1992304.0
Participants: 6
Project status: SIGNED

The discovery of large accumulations of woolly mammoth remains together with Upper Palaeolithic artefacts has fascinated both researchers and the general public since the 19th century. Despite many years of scientific research and dispute our knowledge about these sites and the relationship between mammoths and contemporaneous Upper Palaeolithic hunter-gatherers remains incomplete. This project focuses on the mammoth bone accumulations found in the West Carpathian forelands and seeks to establish why they formed and their function for hunter-gatherer groups 35,000-25,000 years ago – a period of major techno-cultural and environmental change in approaching the Last Glacial Maximum. For the first time we will study materials covering the full chronological range of this archaeological phenomenon, considering both existing collections alongside new fieldwork at the key sites of Dolní Věstonice I, Kraków Spadzista and Langmannersdorf. Site-specific signals of human-mammoth interaction within their local palaeoenvironmental context will be used to investigate chrono-spatial changes in both mammoth populations and hunter-gatherer societies. We will employ standardised field and laboratory protocols that utilise recent methodological and technological advances in ancient DNA research, stable isotope studies, radiometric dating, palaeoenvironmental reconstruction and palaeodemographic modelling. The resulting dataset will allow an integrated investigation of the formation of mammoth bone accumulations and produce a statistically analysable dataset expected to reveal the interactions between human and mammoth populations in Central Europe in the context of palaeoenvironmental changes. This will have great impact not only for Upper Palaeolithic research in Central Europe, but will on a general scale also contribute to an improved understanding of human behaviour, cultural developments, and human adaptation to dynamically changing climatic and environmental conditions.

Keywords: upper palaeolithic,pleistocene
Receptor Recruitment as an Organizational Principle for Self-Assembling Matter (RECRUIT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Receptor recruitment occurs in biology as a response to binding, for example, by virus particles to a cell membrane. The interactions that underlie the binding process are typically multivalent in nature, in other words, multiple interactions of the same motif occur simultaneously to provide a collective, cooperative effect. This project aims to employ recruitment as a design criterium for self-assembling building blocks into well-defined architectures. Intrinsically weak and dynamic interactions are essential in achieving self-assembly and recruitment. Exquisite control over stoichiometry and structure of the assemblies is achieved by harnessing ground-breaking developments in the understanding of these multivalent interactions. Follow-up fixation processes will be developed to transfer the molecular organization onto stable building blocks and materials. Functional, e.g., fluorescent, groups will be implemented into the systems to provide insight into recruitment and self-assembly processes. These breakthrough insights will be used tackle challenges with the identification, sensing and isolation of biological particles. High-throughput methods will provide technology to screen multiple virus–glycan combinations with the aim of providing ‘fingerprints’ of viruses based on their binding behaviour. Platforms with nanoscale dimensions and molecular functionalities will be prepared, which will be used for single-particle sensing and particle isolation of, for example, virus particles and extracellular vesicles. As such, this proposal takes inspiration from nature, by borrowing recruitment as a concept to build self-assembled materials, and to contribute to a better understanding of living systems using new detection and isolation tools, with application prospects for biomedical platforms and smart materials.

Keywords: self assembly multivalent interactions molecular recognition superselectivity supramolecular interactions at interfaces
Structuring spatial knowledge through domain-general, non-spatial learning mechanisms (OutOfSpace)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1499688.0
EU funding (EUR): 1499688.0
Participants: 1
Project status: SIGNED

Is space the main organizer of our mental reality? The answer to this question is apparently "yes". According to recent views, nearly any type of knowledge would be organized through low-dimensional geometries relying on the same computations that are at play in the navigation of the physical space, as attested by the involvement of the hippocampal-entorhinal region in high-level cognition. From an evolutionary standpoint, spatial processing mechanisms might have thus developed from originally mapping the navigable environment to representing cognitive spaces. Moving beyond this spatiocentric view of the human mind, OutOfSpace will test the fascinating yet apparently counterintuitive hypothesis that non-spatial associative learning mechanisms are active (if not the main) ingredients in structuring spatial representations. To pursue this aim, OutOfSpace will employ cognitively plausible computational models (i.e., distributional semantic models) based on non-spatial associative learning mechanisms to extract latent knowledge from natural language; this non-spatial information will be then used to predict a variety of spatial representations, using a pioneering interdisciplinary approach that combines computational, behavioural, eye tracking, fMRI, TMS-EEG and intracranial EEG work in both sighted and blind individuals. OutOfSpace will thus make a breakthrough on two fronts: (i) probing whether language - a non-spatial learning environment - can encode and recode spatial knowledge without the need for a dedicated spatial memory system; (ii) attesting the strict interplay between spatial and non-spatial learning mechanisms in structuring mental representations. More generally, these findings will open the venue to developing a more comprehensive, empirically-based cognitive neuroscience framework for processing and representing spatial information.

Keywords: cognitive maps spatial representations associative learning mechanisms semantic memory distributional semantic models hippocampal entorhinal system parietal cortex
Innovative cultivation methods for marine biodiscovery (COMBO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Ireland,France,Netherlands,Denmark,Spain,Belgium,Greece
Call: Novel culturing of aquatic organisms for blue biotechnology applications (HORIZON-CL6-2023-CIRCBIO-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4575908.75
EU funding (EUR): 4380450.0
Participants: 14
Project status: SIGNED

Despite their well-recognized potential, marine bioactive molecules are still difficult to source due to a lack of controlled culturing and processing infrastructures, and their chemical synthesis is hampered by their chemical complexity. The marine environment is largely affected by global change and wild harvesting of marine bioresources does not represent a sustainable supply of these biomolecules. The main sources of the high-value biomolecules are corals, sponges, algae, involving industrial end-users in the medical and pharmaceutical, food, and cosmetic sectors. Therefore, new approaches are urgently needed in marine biotechnology as microbial engineering has not fully met the expectations for producing the marine bioactives identified in invertebrates and seaweeds. Recent advances in thesynthetic biology of terrestrial natural products are offering unique opportunities to supply bioactives of terrestrial origin. Omics technologies have also transformed the way the complexity of the marine holobiont can be viewed and today the integration of omics data such as genomics and metabolomics can increase our understanding of the functioning and processes of living organisms including their metabolic pathways. COMBO will allow the transfer of knowledge from terrestrial to marine biotechnology through the engineering of marine metabolic pathways using Omics approaches. The rationale behind COMBO lies in the power of synthetic consortia of host cells and microbial cells based on the concept of holobiont and auxotrophy. To this end, we will exploit the recent advances in co-cultures systems. Indeed, the development of synthetic consortia has been shown to support specific ecological dynamics, promote microbial species growth, and syntheses of valuable chemicals. COMBO will therefore expand the potential offered by underused marine sponges and seaweeds known to produce bioactives such as terpenoids and alkaloids for the cosmetic and pharmaceutical markets.

Keywords: biodiscovery,cell culture