Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Building knowledge and tools to advance on promoting of freshwater urban ecosystems as nature based-solution for health and wellbeing in a changing word (StreamScape)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 2
Project status: SIGNED

Cities around the world are undergoing significant transformations and are facing substantial challenges in the form of urban of climate change and ongoing urbanisation. The idea that we can work with nature to improve our cities is now seen as vital. The concept of Nature-Based Solutions has emerged to foster sustainable development by transversally addressing social, economic, and environmental urban challenges. Although the attention to nature-based solutions inclusion is an important pillar of urban sustainability, a clear understanding how they can be implemented in the freshwater landscape, is still missing, even in face of the relevance of the urban freshwaters to wellbeing of the population. This investigation aims to fill this gap, by analysing the social and environmental impacts of urban streams as important nature-based solutions from protecting water quality to reducing natural hazards while preserving biodiversity and providing health and wellbeing benefits to population. By selecting as case studies Aveiro and Coimbra, the research project aims to promote the urban streams and their multiple ecosystem services as important nature-based solutions to mitigate the effects of urbanization and climate change on aquatic ecosystems, in the human health and in the wellbeing of the population. The project will adopt the research strategies: to assess how urban development affect a capacity of urban streams to provide ecosystem services using well-established scientific methods and investigate how the degradation of urban streams reflects on the local residents’ perception of the ecosystem services in terms of benefits, health and wellbeing. In addition, thematic maps of ecosystem services identified in the urban streams will be produced to demonstrate the relevance of urban streams for ecological, cultural and social aspects and to demonstrate can this information can be useful to urban planning and governance.

Keywords: urban water ecosystem services stream ecology,environmental change nature based solutions people wellbeing
Harnessing Novel Micropeptides in Cardiomyocytes to promote Cardiac Regeneration (Novel.CaRe)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1592281.0
EU funding (EUR): 1592281.0
Participants: 2
Project status: SIGNED

Despite advances in clinical care, heart failure consequent to myocardial infarction remains a leading cause of mortality worldwide. Absence of cardiac regeneration post-infarction is mostly explained by the reduced mitotic potential of adult cardiomyocytes, that, in comparison with their embryonic counterparts, have an accumulation of morphological, metabolic and biochemical adaptations that render them recalcitrant to proliferation. Devising tools to precisely control the maturational status of cardiomyocytes would enable novel therapies for cardiac regeneration, either by stimulating cell cycle reentry of pre-existing cardiomyocytes, or enhancing the maturational status of cardiomyocytes derived from induced pluripotent stem cells for cell therapy. Novel.CaRe will explore the therapeutic potential of micropeptides, a novel class of proteins that, despite their small size, can play major cellular roles. Based on extensive preliminary work, I propose an ambitious interdisciplinary research program bridging advanced omics, animal models, human samples, bioinformatics, cellular phenotyping and innovative strategies for gene therapy. We will apply new translatomics and proteomics approaches to identify micropeptides conserved across species and modulated during cardiomyocyte maturation, define their cellular functions and test their potential to induce proliferation of cell cycle withdrawn cardiomyocytes or enhance maturation of stem cell-derived cardiomyocytes. In a high-risk, high-gain part of the project, we will develop a novel approach for gene therapy enabling time-controlled, cardiomyocyte-specific expression of a combination of micropeptides normally expressed by embryonic cardiomyocytes and assess if this strategy successfully promotes regeneration of the adult heart post-injury. In conclusion, Novel.CaRe will generate new resources, technology and knowledge, pushing beyond the state-of-the-art in the fields of molecular cardiology and cardiac regeneration.

Keywords: heart,multiomics datasets,micropeptides,cardiomyocyte maturation,cardiomyocyte proliferation,gene therapy of cardiovascular disorders,cardiac regeneration,myocardial infarction
DETECTION OF SINGLET OXYGEN IN DIRECT LIGHT THERAPY FOR GLIOMA TREATMENT (TOGETHER)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Serbia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 20.0
Total project cost (EUR): 585211.25
EU funding (EUR): 585211.25
Participants: 2
Project status: CLOSED

Gliomas are highly lethal brain tumours, which are challenging to treat because of their diffuse structure in the brain and inaccessibility to chemicals and traditional chemotherapy due to the existence of the blood-brain barrier. To overcome this, the GlioLight project team is developing novel light sources for ultra-short laser pulses for direct light therapy (USP-DLT), thus revolutionising glioma therapy. The underlying mechanism of DLT is direct stimulation of the reactive oxygen species production in brain tissue, among which the singlet oxygen (1O2) is most directly connected with tumour tissue elimination. To facilitate the translation of the GlioLighT results and clinical application of the USP-DLT, the team from VINS will join GlioLighT through the TOGETHER Hop On project and establish a numerical model that will correlate the in vivo 1O2 concentration with the parameters of light propagation through the brain, thus helping in the dosimetry and representing the step forward the personalised glioma treatment. Determining 1O2 concentration by measuring its photosensitiser-free phosphorescence in vivo is challenging because of its low 1O2 yield, short lifetime, and interference with a biological background. These problems are solved by evolving a new technology that uses time-correlated multiple photon counting (TCMPC) near-infrared photomultiplier tube (NIR-PMT) detection systems. Therefore, the aim of the TOGETHER project is to use TCMPC and collect the data for the numerical 3D model used for the USP-DLT dosimetry for treating glioma. VINS will establish an in vitro and in vivo mouse model, customise the TCMPC detection system, collect the data and develop a numerical model. Widening instruments will be exploited to boost the VINS team's excellence and strengthen its innovation capacity, and help increase GlioLighT's impact on widening countries.

Keywords: glioma,singlet oxygen,reactive oxygen species,detection,photodynamic therapy
Mechanical Impact on Non-silicon Devices: Stress Effects on Technology (MINDSET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

This project aims to imply the co-integrated externally applied Mechanical Stress (MS) up to GPa levels by nanoindentation with electrical characterization setup and on-chip heating capability to study the properties of Non-silicon Devices (ND), specifically two-dimensional Transition metal dichalcogenides (2D TMD) and indium gallium zinc oxide (IGZO) based devices to explore the multitudinous electrical, physical, and reliability characteristics and creating accurately-calibrated models to predict the Stress Effects on Technology (SET). The project encompasses three objectives, which are further subdivided into five work packages (WPs) for easy flow and achievement of the goal. The first objective is to Integrate non-silicon FETs with an on-chip heating to Co-integrated electro-mechanical setup. The first objective paves the way to lead us to our second objective, in which the Dual Assessment with Electro-mechanical and Reliability Characterization of 2D TMD and IGZO FETs with MS and heating is performed. Finally, to corroborate the understanding and the physics of devices, accurate modelling and simulation will be performed in the third objective using the finite element method (FEM) and technology computer-aided design (TCAD), which will be calibrated with experimental data as obtained in the second objective. This project will be valuable for gaining insights into the factors that influence the behaviour of non-silicon-based FETs, including an additional factor like mechanical stress in addition to heating.

Keywords: electrical and electronic engineering,semiconductors,mechanical engineering,simulation engineering and modelling,nanotechnology,nanomaterials,nano engineering
Synergistic Combination of Immunolabeling and Molecular Imaging Technologies for Art Research (SCIMITAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-23
End date: 2025-10-22
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Our cultural heritage is our shared past and should be preserved for future generations. In order to preserve an art object, it is not only essential to study its structure, creation, history, and significance, but it is also necessary to understand its past and current state as well as projected changes in the future. In the case of old paintings, this requires being able to correlate macroscopic observations with its chemical make-up at the microscopic level. Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is a powerful chemical imaging technique, especially suited for heterogeneous systems such as paintings. ToF-SIMS can simultaneously localize and identify organic and mineral components and has the highest spatial resolution of all the molecular imaging mass spectrometry techniques. The sub-micrometer spatial resolution of ToF-SIMS is needed to investigate painting micro-samples that consist of sub-millimeter stacked layers of dried paint that contain both organic and inorganic ingredients. Case studies published over the last two decades attest to the potential of ToF-SIMS in providing information relevant for painting conservation. However, the resulting imaging datasets are very complex often causing a large proportion to remain unexploited. The high energy ion source of the instruments also causes larger biomolecules such as proteins to fragment, making it impossible to identify them. Meanwhile, a variety of protein-rich ingredients coexist and age in paintings, which means that identifying their nature would be extremely valuable to conservation experts. The proposal aims at tackling these weaknesses by developing methods to unambiguously identify the materials found in the heterogeneous microstructures of old paintings samples using a ToF-SIMS instrument with novel Tandem MS imaging capabilities as well as the development of a ToF-SIMS-based immunohistochemistry relying on metal-labeled antibodies to allow for targeted protein imaging.

Keywords: imaging mass spectrometry,paintings,microstructure,antibodies,tandem ms
A Century of Care: Invisible Work and Early Childcare in central and eastern Europe (CARECENTURY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

How did caretakers rooted in families, communities and societies nurture very young children across historical time? And, how have care practices changed across different peoples, states and political economies in the dynamic 20th century? This ambitious project answers these important, yet mostly overlooked, questions with a comparative study of early childcare in central and eastern Europe from 1905 to 2004. The late Habsburg Empire and, after 1918, six of its successor states offer an ideal laboratory to explore how the invisible work of caretaking was impacted by changing political, social and economic circumstances. In this ethnically and religiously diverse region, care continued during depressions, wars, genocides, displacements and revolutions. This project will be the first to study early childcare in this region systematically and conceptualize the history of private and public caretaking in early life more broadly. To achieve this goal of defining and explaining care practices, this project has three objectives: (1) to show the nature and scope of the invisible work required during the first 1,000 days of life using unexamined voices, spaces and things; (2) to use insights from sociological and economic literatures to conceptualize and theorize the caretaking regimes of central and eastern Europe and explain continuities and discontinuities of caretaking within one diverse region, and (3) to examine the afterlife of caretaking regimes after 1989 and European Union expansion, while also exploring the legacies and debates about caretaking which endure today. This project hypothesizes that caretaking regimes – a collection of medical beliefs, moral assumptions, new technologies and advances in material culture –interacted with changing political economies and inherited religious and ethnic sensitivities. Variations across this interaction explain how and why caretakers utilized some childcare practices and not others in this illuminating milieu.

Keywords: care,early childhood,invisible work,material culture,visual studies
Development and Demonstration of Digital Building Logbooks (Demo-BLog)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Countries involved: Netherlands,Germany,Belgium,France,United Kingdom
Call: Demonstrate the use of Digital Logbook for buildings (IA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4510940.0
EU funding (EUR): 3891871.26
Participants: 17
Project status: SIGNED

Transparency and access to information are critical for the European energy efficient and sustainable buildings market. Construction, building occupation/management, transactions and investment and financing decisions heavily rely on transparent data availability. Limited information availability and lack of a common digital data repository increase costs and inefficiencies in designing, constructing, operating and financing buildings. The CEAP recognises Digital Building Logbooks as circularity enablers and the Renovation Wave states that DBLs will integrate all related data from upcoming building renovation passports, smart readiness indicators, Level(s) and EPCs. Demo-BLog brings together: (i) 5 different DBLs with a total of 4.5 million registered units and a wide variety of target groups (homeowners, municipalities, building professionals and architects) offering scale and diversity; (ii) 4 diverse functionalities addressing key societal challenges, ranging from ‘quick wins’ (renovation and advice and (community driven) decarbonisation pathway) to complex industrial transaction objectives (circularity); (iii) partners, frontrunners in R&D, policymaking and market implementation in highly visible platforms over the last 5 years and (iv) substantial opportunities to build and leverage parallel projects and activities focussed on evolving/scaling the participating building logbooks. The DBLs demonstrated in this project have the potential to eventually reflect the whole lifecycle with a capacity for unlimited data access, input and output, and data export. They are also capable of embracing future technological developments, such as widespread use of BIM, IoT, digital twins and blockchain. Demo-BLog has considerable potential to optimise the use of resources and waste, performance prediction, visual analytics and energy management contributing to the overall goal of “making Europe the first digitally led circular, climate neutral and sustainable economy”.

Keywords: building data,energy efficiency,circular building
Precise, Global Temperature Data for a Growing Planet (HiVE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Belgium
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-12-01
End date: 2025-07-31
Duration (months): 32.0
Total project cost (EUR): 3506281.25
EU funding (EUR): 2454396.88
Participants: 2
Project status: SIGNED

Food security is an urgent global challenge. To feed a population of 10bn by 2050, we must produce 50% more food despite water scarcity, loss of arable land, & climate change. Lack of water (water stress) severely reduces crop yields. The inability to measure water stress accurately leads to unpredictable and low-yielding harvests, impacting the entire food supply chain from farm viability to food prices. Current crop health data is not fit for purpose, leading to ineffective irrigation consuming 70% of global freshwater. ConstellR will provide the first high-precision temperature data at field level, daily & globally from a uniquely scalable constellation of microsatellites (HiVE), enabling water stress detection in time to prevent yield loss. The EIC project will develop & launch an MVP constellation, generating the data required to increase global food production by up to 4%, reduce agricultural water waste by up to 180 gigatons, & avoid up to 94M tons of CO2 emissions.

Keywords: land surface temperature,data services,water stress,food security,irrigation,evapotranspiration,field level,high spatiotemporal resolution,water productivity,daily revisit,miniaturised payload,microsatellite,mission architecture,constellation,data distribution,data processing,thermal infrared
Flawless and sustainable production of composite parts through a human centred digital approach (FLASH-COMP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Spain,Portugal,France,Austria,United Kingdom,Italy,Israel,Switzerland,Germany
Call: Zero-defect manufacturing towards zero-waste (Made in Europe Partnership) (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 6660986.75
EU funding (EUR): 5612470.0
Participants: 16
Project status: SIGNED

The reduction of manufacturing waste is a key challenge to achieve a EuropThe reduction of manufacturing waste is a key challenge to achieve a European transition towards climate neutrality and the goals of the Green Deal. In this context, to achieve the zero-defect manufacturing paradigm has becomes a must for those European productive companies that wants to take the step towards sustainable production. Composites play an important role in strategic European manufacturing sectors like energy, aerospace, naval or automotive, with a growing forecast. So, FLASH-COMP project will develop a human-oriented solution, capable of identifying in an early-manner feasible defectiveness in composite parts manufacturing and to determine if corrective actions should be adopted. All with the ultimate goal of optimizing the composite manufacturing process, reaching zero-defects and consequently, reducing the generation of waste ?process and product associated. FLASH-COMP will develop non-destructive inspection and monitoring instruments to retrieve key process parameters. Will develop an on-line Defect Severity Estimation Tool that will predict the appearance of defects and will estimate their severity to suggest the optimum Feedback and Feedforward control strategies. And will develop a decision support system. In addition, an interoperable software platform for data-sharing will be created. The full FLASH-COMP solution will be demonstrated in a test bed, enabling the experimental validation of the FLASH-COMP concept, and 2 industrial use cases, assuring its future replicability, and paving the way for a future exploitation of results. FLASH-COMP will include a complete skills development training program since the FLASH-COMP solution has been conceived to assist the operator in controlling and making decisions about the manufacturing process. Finally, the project will deal with the development of a standardization roadmap, to ensure the widest possible impact of project results

Keywords: zero defect,first time right,composite manufacturing,non destructive monitoring and inspection,real time control strategies,ai based simulations,data sharing,efficient use of materials