Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Orders and Borders of Global Inequality: Migration and Mobilities in Late Capitalism (MIGMOBS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Italy,Argentina,Japan,United Kingdom,Ireland
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2491015.0
EU funding (EUR): 2491015.0
Participants: 5
Project status: SIGNED

MIGMOBS investigates how borders and hierarchies are maintained between “the West and the Rest”, even as those who are internationally mobile sometimes succeed in challenging the “birthright lottery” - i.e. that citizenship at birth most determines someone’s chances in life. It asks: How does changing categorisation of subordinate populations worldwide in terms of “migration”, “free movement”, and “minorities” relate to these in- and between- country inequalities? It echoes critical migration, mobilities and borders scholars who argue that late capitalism in liberal democracies continues to advance through an ever more sophisticated differentiation and management of population – at the border as well as internal to states. Such work, though, has not adequately examined variation regionally, or across historical shifts in political economy: from post-war liberalism, through neoliberalism, to the era of COVID and beyond. MIGMOBS thus explores in unprecedented empirical breadth and detail how states reproduce sovereign power in an otherwise porous world: selecting and extracting wanted or recognised movers as “immigrants”, brutally excluding many other “migrants”, while simultaneously rendering fluid and untroubling a vast range of banal “mobilities” such as tourism and business travel. Mapping physical, virtual and non-human mobilities, the project details demographic and social connections over time between 21 states. This quantitative comparative historical work underpins co-productive ethnographic case studies rethinking a range of archetypal “migration systems” in and from Europe, Africa, Asia and South America. These investigate how subordinate populations resist the categories, statuses and borders imposed upon them. With the pandemic’s impact on border crossings and transactions, new modes of classification and accreditation suggest an increasingly precise biometric control of movement and behaviour: a new phase of late capitalism I call “viral liberalism”.

Keywords: migration,mobilities,global inequality,inequalities,development,borders,diversity,liberalism,racism,globalisation,governmentality,transnationalism,decolonial thought,political demography,mixed methods
Boltzmann models for polyatomic gases and mixtures: analysis, macroscopic limits and entropy methods (BAME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria,Portugal
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-05-07
End date: 2027-05-06
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 2
Project status: CLOSED

BAME is a project in applied mathematics tackling problems in kinetic theory of gases. We will focus on the system of Boltzmann-like equations that describes gas mixtures composed of monatomic and polyatomic gases. Experience has shown that kinetic models accurately describe strong nonequilibrium processes in gas flows. However, most of the mathematical theory is limited to the oversimplified case of a single monatomic gas. Our aim is to contribute in filling this gap between study of more intrigant gases suitable for applications and the current state of the art in mathematical theory of kinetic equations. Objectives are to study regularizing effects of the Boltzmann operator, integrability, smoothness and strict positivity of solutions, with the ultimate goal of encoding large time behavior using entropy methods. The project will bring together the researcher with distinguished expertise in modelling and analysis of polyatomic gases and mixtures at the mesoscopic level and the host with ground-breaking work on entropy methods for macroscopic systems. The two levels of descriptions will be bridged formally through hydrodynamic limits at the secondment, leading to the redesign of entropy production program to the system of interest. The fellowship will enable the researcher to gain new analytical skills and greatly improve transferable skills through the reach training offer at the host University of Graz. Moreover, it will significantly extend her research network and facilitate participation in leading events in the field, leading to the capability to launch her own research group in the future and to enhance the career perspectives in academia.

Keywords: kinetic theory,system of boltzmann like equations,polyatomic gases,multi component gas mixtures,entropy methods,integrability propagation,regularity propagation,hydrodynamic limits
Metal-Organic REagents for Light-Enabled Shuttling of protons and electrons (More4Less)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1498250.0
EU funding (EUR): 1498250.0
Participants: 1
Project status: SIGNED

Protons and electrons are the currency of energy conversion and play a key role in some of the most transformative technologies such as the reduction of N2, CO or CO2. Exploiting water and sunlight as renewable resources for these transformations offers a means for solar-to-chemicals conversion. Thus, our ability to control the transfer of protons and electrons preventing the more favourable formation of H2 poses an exciting fundamental problem. Strategies based on proton coupled electron transfer (PCET) have demonstrated key benefits by providing low energy pathways that bypass the most energetic, charged intermediates. However, important problems remain regarding the development of PCET shuttles that: (1) behave as catalysts harnessing water and light, (2) promote multi PCET to avoid unstable radical intermediates that undermine the selectivity and efficiency, and (3) can be integrated in complex multielectron/multiproton transformations relevant to solar energy conversion such as N2 reduction. I will address these problems by designing metal-organic PCET shuttles that target three specific objectives: (1) to merge light and electricity for reductive PCET in a novel photoelectrocatalytic strategy using molecular shuttles that exploit counter oxidation reactions of practical relevance, (2) to achieve an unprecedented control over multi PCET to impact the selectivity of reductive transformations via the colocalization of redox and acid/base sites within coordination cages, and (3) to integrate photo(electro)catalytic PCET in small molecule catalysis with new tandem approaches towards the reduction of N2 using light and water. Overall, these objectives will provide unconventional tools to affect the mechanisms of reductive reactions. Besides transgressing the frontiers of knowledge in the field of PCET, and more generally energy conversion, More4Less has the potential to change the paradigm in which we develop catalytic systems for solar-to-chemical transformation.

Keywords: redox catalysis,electrocatalysis,photocatalysis,solar fuels,solar to chemicals,energy conversion,small molecule catalysis,nitrogen reduction,molecular materials
Exploring the molecular grammar of IDP assembly and condensation at ultra-high throughput (EMMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1995554.0
EU funding (EUR): 1995554.0
Participants: 1
Project status: SIGNED

The last years have seen unprecedented breakthroughs in protein structural biology, with the resolution revolution in cryo-electron microscopy and the release of AlphaFold. The combination of advanced experimental structural biology, machine learning algorithms and molecular simulations has put the fully quantitative description of how the structure and interactions of folded proteins are defined by their amino acid sequence within close reach. This leaves us with a final frontier in protein science, namely to achieve a similar level of understanding for intrinsically disordered proteins (IDPs). The energy landscapes of IDPs often comprise a multitude of nearly isoenergetic states, that include assembled forms, such as amyloid fibrils and liquid condensate droplets. Much effort has been spent in order to achieve an understanding of the molecular grammar of IDP assembly and condensation, i.e. how amino acid sequence defines both kinetics and thermodynamics of these processes. Current state of the art is to evaluate a few dozens of sequence perturbations quantitatively in vitro. In EMMA, I propose to develop a fundamentally new approach that will ultimately allow to improve on current methods by more than 8 orders of magnitude. This ground-breaking improvement will be achieved by exploiting the power of mRNA display, in which the biophysical behavior of each individual sequence within large libraries of protein-mRNA constructs can be evaluated in a “one pot” reaction. We will combine quantitative screening of the energetics of liquid condensate droplet formation of up to 10^10 sequences by mRNA display with a multiparametric biophysical toolbox that allows the key thermodynamic and kinetic parameters of binding and assembly to be evaluated for thousands of selected sequence variants. EMMA will transform our ability to probe the mechanisms and interrelationships of the interactions and assembly processes that define IDP function and disease-related malfunction.

Keywords: amyloid,liquid liquid phase separation,mrna display,energy landscape,sequence space exploration
Manifestations of Social Determinism in Picaresque Video Games (MASQUES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Video games are one of the most popular cultural media nowadays. Their narratives frequently feature rogues suffering the consequences of social determinism, one of the main characteristics of Picaresque Fiction. Social determinism involves circumstances such as social oppression or ethnic/gender discrimination. Due to this, certain contemporary and past worldviews, as well as current social challenges permeate Picaresque texts, allowing players to experience complex sociocultural contexts through rogues and fictional stories. Built upon my previous research that demonstrates the existence of a videoludic Picaresque that continues the legacy of Picaresque Literature, this project offers increased understanding of this type of contemporary Picaresque fiction insisting in the expression of the current social challenges that imbue it. The primary goal is to show how social determinism is embedded in these video games while manifesting worldviews aligned with contemporary social challenges and influenced by previous Picaresque Literature. Considering narrative and ludic aspects of this cultural medium, a model of analysis for the social determinism in video games will be developed using a multidisciplinary theoretical framework with the intention of exporting it to different media and genres. Despite not existing previous work that study social determinism in the videoludic Picaresque, there are authors who have explored this characteristic in Picaresque Literature, the worldviews of this type of fiction, or manifestations of oppression and discrimination in video games. This project will combine these theories, create new ones, and apply them to video games using a new model shaped with the blended multidisciplinary support of three renowned centres of humanistic knowledge of the University of Glasgow: the Centre for Comparative Literature and Translation, the Stirling Maxwell Centre of Text/Image Cultures and the Games and Gaming Lab.

Keywords: picaresque literature,comparative literature,video games,text and image,history of ideas,transmedia studies
Nanobody-Targeted Camk2d Inhibition for Cardiac Arrhythmias (Nab-Heart)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Italy,Spain
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 3
Project status: SIGNED

In cardiac cells, kinase enzymes are key modulators of calcium homeostasis, mitochondrial function, excitation-contraction coupling, and metabolism. Of these, the delta isoform of Ca 2+ /Calmodulin-dependent kinase (Camk2d) is particularly relevant to the induction of life-threatening cardiac arrhythmias.Of the several promising small molecule and peptide Camk2d inhibitors proposed in pre-clinical investigations, none has entered clinical applications. The severity of side effects, a well-known issue for kinase inhibitors, in this case is further amplified by the high homology and the unique Ca 2+ -dependent regulatory physiology among four Camk2 isoforms, plus the delicate role of the ubiquitously expressed Camk2d in non-cardiac tissues. Since the major obstacle to developing a cardio-specific, Camk2d-specific inhibitor mainly relies on reaching high isoform selectivity, the Nab-Heart project will conjugate selected Nanobodies (Nbs) to a new Camk2 inhibitory peptide to develop the first selective kinase inhibitor. Such a molecule will prevent the development of life-threatening arrhythmias in a variety of cardiac conditions, spanning from inherited arrhythmias such as Long QT Syndrome to acquired and highly prevalent diseases such as atrial fibrillation and heart failure. The team will identify Nb candidates with the desired Camk2d isoform-selectivity and affinity. Optimized substrate-mimicking Camk2d-inhibitory peptides will be covalently linked to the selected Nbs (Nb-inibs) to ensure delivery of the inhibitory module to the pathologically active Camk2d target with outstanding selectivity and affinity. The strategy will be validated in vivo through cardio-specific AAV9 delivery of the Nb-inib candidates in a mouse model of Catecholaminergic Polymorphic Ventricular Tachycardia and in a Swine model of acquired heart failure, where Camk2d is known to be the trigger of life-threatening arrhythmias.
Saving Cardiac Arrest Patients with Hypothermic Lung Conservative Liquid Ventilation (Luncolive)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 3620834.38
EU funding (EUR): 2449869.0
Participants: 1
Project status: SIGNED

Orixha offers a major clinical breakthrough in Critical Care with its unique LUNg COnservative LIquid VEntilation (hence LuncoLive) technology. It powers the Vent2Cool medical device to induce ultra-rapid protective cooling of heart and brain of resuscitated cardiac arrest patients. Vent2Cool will increase their survival rate by tackling the reperfusion injury of Post Cardiac Arrest Syndrome . LuncoLive project will enable clinical validation of Vent2Cool as a new gold standard for post-resuscitation care. Orixha will industrialize and miniaturize the technology to increase usability as well as reduce costs and environmental impact, in particular through recycling of the Liquid2Breathe breathable liquid. Its success will enable Orixha to market the first Vent2Cool devices in the EU by 2028 and reach profitability by 2030. It will also strengthen Orixha's ability to develop future applications for respiratory support and pre-hospital emergency care.

Keywords: medico economics,clinical trial,recycling consumables,intensive care,breathable liquid,respiratory support,respiratory distress,temperature management,therapeutic hypothermia,quality of life,ventilators,resuscitation,cardiac arrest,liquid ventilation
Trading Chinese Migrants: Networks of Human Trafficking in Treaty-Port China (1830-1930s) (TRACMI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

Despite the excellent work of historians in the past three decades to provide a comprehensive history of the Chinese coolie trade, the trafficking of women and children remains still underrepresented. This innovative project will use cutting-edge data technology to track, for the first time, the networks operating the trade in children, women, and male labourers in an integrative perspective. It will trace how the private sector, such as intermediaries and companies, and the nations involved shaped the history of international forced migration in nineteenth-century China. Relying on my supervisor's technical expertise, I will mobilize a wealth of quantifiable data accessible on international human transportation in the form of an openly available database to analyse and depict the systems connecting these various forms of bondage. In the past four years as a postdoctoral researcher, I have collected an outstanding amount of data from unpublished multilingual source material, scattered in archives in Europe, Asia and America. During the MSCA-PF, I will undertake further research in Cuba, the UK, France, Spain and Germany to gather the sources needed to complete the datasets and to publish the results in a monograph and a journal article. The data collection will convey a novel contribution to the existing database project Exploring Slave Trade in Asia (ESTA), an international collaboration by the International Institute of Social History in Amsterdam, the École Normale Supérieure (ENS) de Lyon, the Bonn Center for Dependency and Slavery Studies (BCDSS) and Linnaeus University. The database will be the structure for a future document preservation project to pursue in more advanced grants. My training at the ENS and the BCDSS will strengthen my specialization as a sinologist, integrate me in state-of-the-art scholarship on Asian bondage, and equip me with the technical and academic abilities needed to boost my career prospects.

Keywords: coolie trade child trafficking female trafficking imperialism labour migration qing history spain great britain portugal southeast asia cuba peru treaty port china bondage dependency
Neural encoding of wetness perception in the cortex. (WETNEURONS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Perception depends on the representation of external information in the cortex. This information enters the nervous system thanks to receptor proteins in your sensory neurons. These receptors transform external energy into neural activity. It follows that, if you do not have receptors sensitive to an environmental property, you cannot perceive such property. For example, humans are not able to sense electric fields, whereas some fish can because they have electroreceptors. A sense required for survival is wetness due to its role in thermoregulatory responses. Unlike insects, humans lack hygroreceptors sensitive to the level of moisture of the skin, yet we have clear sensations of wetness. So, how do we feel wetness? Researchers think that these sensations emerge from the integration of thermotactile signals in the cortex, but the location or cellular encoding of wetness in the cortex is unknown. Therefore, I propose to study the neural basis of wetness sensations in mice. The mouse is an ideal mammalian model for this because their thermotactile system is similar to ours and tools to measure neuronal activity can be combined with behaviour. Crucially, researchers have recently found a co-localised representation of thermotactile stimuli in the mouse cortex. First, I will develop wet stimulators for use in mice based on designs from human studies. Second, I will measure wetness sensations in mice by developing a novel perceptual task. Third, I will use calcium imaging techniques to identify and study cortical neurons activated during wetness sensations. Finally, I will use optogenetics to provide a causal relationship between neural activity and wetness sensations. This project will advance our understanding of how wetness sensations emerge through cortical activity, even in the absence of a wetness receptor. The research output will advance our understanding of brain function, but also will be of interest to the clothing, cosmetic and virtual reality industries.

Keywords: wetness perception thermotactile system somatosensation multisensory integration imaging cortical activity