Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High-temperature angular-selective radiant surfaces for the de-carbonisation of energy intensive industries. (HEASeRS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-15
End date: 2024-03-17
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Energy Intensive Industries (EII) heavily rely on High-Temperature Processes (HTP), notoriously hard to de-carbonise. To meet its carbon neutrality goal, Europe will need to increase the share or dispatchable renewable electricity on the grid and significantly increase the efficiency and electrification of HTP, particularly via electric heating. At high-temperatures, radiation is the dominant heat transfer mode. There are very few technological options available to improve and control the radiative properties of materials able to survive the aggressive oxidation and thermomechanical stresses that occur in HTP. The lack of radiative control reduces the energy efficiency and electrification potential of HTP. The HEASeRS (High-tEmperature Angular-Selective Radiant Surfaces) project explores an innovative approach to spectro-angular radiation control based on the modification of the surface geometry of industrially relevant high-temperature materials at multiple length scales: surface roughness, meso-structures and macro-scale system geometry optimisation. This approach is generally applicable to all HTP and exempt of most of the limitations of existing design paradigms. The findings are applied to a series of proof-of-concept designs targeting innovations in the design of efficient heat exchangers, radiant furnaces, and Concentrated Solar Power (CSP) receivers. CSP is a promising renewable energy technology that can potentially supply high-temperature heat and electricity on demand; and shares many similarities with HTP. The 24 months research, based at IME (Madrid, Spain) with a secondment at LTeN (Nantes, France), involves a combination of detailed numerical modelling of radiative heat transfers and experimental activities. Industrial relevance, at the core of the research objectives, is promoted through bi-annual project newsletters featuring interviews of EII, technology providers and researchers; and a intersectoral workshop at the end of the action.

Keywords: high temperature,solar,receiver,electrification,heat exchanger,furnace,roughness,optics,radiative heat transfer,geometrical optimisation,angular selectivity,ray tracing
Efficient Manufacturing for Aerospace Components USing Additive Manufacturing, Net Shape HIP and Investment Casting (EMUSIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Spain,Switzerland,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: International cooperation in aeronautics with China (H2020-MG-2015_SingleStage-A, 2015)
Start date: 2016-04-01
End date: 2019-03-31
Duration (months): 36.0
Total project cost (EUR): 2193278.75
EU funding (EUR): 1799993.75
Participants: 13
Project status: CLOSED

This proposal is in response to the call for International Cooperation in Aeronautics with China, MG-1.10-2015 under Horizon 2020 “Enhanced Additive Manufacturing of Metal Components and Resource Efficient Manufacturing Processes for Aerospace Applications”. The objectives are to develop the manufacturing processes identified in the call: (i) Additive manufacturing (AM); (ii) Near Net Shape Hot Isostatic Pressing (NNSHIPping) and (iii) Investment Casting of Ti alloys. The end-users specify the properties and provide computer-aided design, (CAD) files of components and these components will be manufactured using one or more of the three technologies. During the research programme, experiments will be carried out aimed at optimising the process routes and these technologies will be optimised using process modelling. Components manufactured during process development will be assessed and their dimensional accuracies and properties compared with specifications and any need for further process development identified. The specific areas that will be focussed on include: (a) the slow build rate and the build up of stresses during AM; (b) the reproducibility of products, the characteristics of the powder and the development of reusable and/or low cost tooling for NNSHIP; (c) the scatter in properties caused by inconsistent microstructures; (d) improving the strength of wax patterns and optimising welding of investment cast products. The process development will be finalised in month 30 so that state-of-the-art demonstrators can be manufactured and assessed by partners and end-users, during the final 6 months. The cost of the process route for components will be provided to the end-users and this, together with their assessment of the quality of these products, will allow the end-users to decide whether to transfer the technologies to their supply chain. The innovation will come through application of improved processes to manufacture the demonstrator components.

Keywords: powder processing,additive manufacturing,hot isostatic pressing,investment casting,electron beam welding,modelling,demonstrator components,mechanical properties
Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesions (META-DORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2020-06-29
Duration (months): 24.0
Total project cost (EUR): 183792.6
EU funding (EUR): 183792.6
Participants: 2
Project status: CLOSED

While cancer survival rates have improved significantly in recent years, survival decreases dramatically after tumour metastasis. One of the most common sites for metastatic tumours to develop is bone. Intriguingly, evidence suggests that once they have invaded the bone marrow, individual metastatic cancer cells can persist for years in a quiescent or “dormant” state, and are resistant to both radiation and chemotherapy treatment. These dormant cells can reside for months or years while the cancer is in remission, and then “reactivate” without warning to form new, usually fatal, skeletal lesions. Tumour cells achieve this by “hijacking” the normal bone remodelling cycle, a homeostatic balance between bone formation and resorption, to form a metastatic niche within the marrow. However, the signalling mechanisms that cause metastasis and dormancy, particularly in such a mechanically active environment, are poorly understood. Therefore, the goal of this project is to investigate the chemical and physical interactions between bone and cancer cells, both during dormancy and mechanical stimulation, to provide new insight into bone metastatic lesions and explore novel therapeutic targets to prevent cancer metastasis. This will be achieved by culturing specific bone and cancer cell types together for the first time to observe changes in their signalling and behaviour. Dormancy will also be induced, to observe its effect on changes in signalling. Mechanical stimulation will be applied to investigate whether the complex mechanical environment of the bone marrow plays a role in cancer metastasis. Finally, a specific cellular mechanosensor, the primary cilium, which has been implicated in the development of cancer and is known to be involved in bone formation, will be investigated. This will shed new light on its chemosensing and mechanobiological roles in cancer metastasis, as well as explore its potential as a novel target for cancer treatment and prevention.

Keywords: cancer,tumour,bone marrow,mechanobiology,primary cilia,osteocyte
DITAS: Data-intensive applications Improvement by moving daTA and computation in mixed cloud/fog environmentS (DITAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Spain,Israel,Spain,Greece,Switzerland
Call: Cloud Computing (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 4890066.25
EU funding (EUR): 4420187.5
Participants: 11
Project status: CLOSED

There is an increasing need to develop data intensive applications able to manage more and more amounts of data coming from distributed and heterogeneous sources effectively, quickly, correctly, and securely. However, the current adoption of Cloud Computing paradigm is not fully appropriate to store and analyse such data: latency, security, and compliance are still significant barriers. At the same time, Fog Computing has emerged as a paradigm promising to fully exploit the potential of the edge of the network involving traditional devices as well as new generation of smart devices, which can process data closer to where they are produced and/or consumed but which cannot ensure the same reliability and scalability as cloud computing offers. The goal of DITAS is to propose a framework, composed by an SDK and an execution environment, which aims to overcome the barriers that now hamper the adoption of Cloud Computing and increase the adoption of Fog computing by exploiting the full potential of these two paradigms in a synergic way. This will support the development and execution of data-intensive application that are now – and even more in the future – crucial for organizations and companies that want to manage their data in an efficient, reliable, scalable, and secure manner. Abstractions provided in DITAS with Data Virtualization and Data Utility will expose the data to be managed by the application in terms of Virtual Data Containers which hide the complexity of the underlying infrastructure composed of heterogeneous data sources, smart devices, traditional servers, and sensor networks Distribution could also change dynamically. Conversely, Virtual Data Containers offer to developers the possibility to express requirements on data in terms of performance, quality, security and privacy thus to focus only on the application logic, leaving to the DITAS execution environment the responsibility of finding, processing, and delivering the data according to user needs

Keywords: mixed cloud,fog computing,data and computation movement,data virtualisation,data utility
TechNovator XE remote wireless charging (TechNovatorXE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Poland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The number of electronic devices that people use in their everyday life is continuously growing. However, it becomes increasingly difficult for people to monitor and timely recharge all the batteries. The necessity of monitoring the level of gadgets charging keeps users on constant tenterhooks. Also, environmental problems are a big issue: with the increasing number of electronic devices, the amount of wires, cords and batteries increases dramatically, and they are rarely being recycled. Even under the conditions of Batteries Directive the realistically achievable share of collected waste is only 30-40%. The emergence of a wireless charger that synchronously charge all of the nearby devices, would greatly facilitate people’s life. According to Global Market Insights, the wireless charging market worth $3.67 billion in 2016 (grew around 40% compared to 2015), and is projected to reach $25.67 billion by 2023. However, all existing wireless charging solutions available on the market are actually not remote, as they require gadget to be placed on the charging pad and it cannot be moved until fully charged. TechNovator XE (TRL 6), developed by TechNovator, is a unique remote wireless charging solution that effectively charges multiple devices simultaneously at a long distance within range of the transmitter (5 meters radius), and is completely safe for people and the environment. The system also has a unique feature “battery charging level control” that is achieved through constant battery level monitoring and autonomous charge if it is below the certain level that the user can set up in the application. To ensure successful commercialization, in Phase 1 of SME Instrument, TechNovator intends to develop an elaborate feasibility study for TechNovator XE remote wireless charging solution commercialization that would include: a thorough analysis of market and user needs, business model, business plan, and IPR strategy development.

Keywords: wireless charging,wireless charger,wireless,safe rf wireless charging,remote charging,wireless smartphone charging
Physiologically Crowded Artificial Cells for Relevant Drug Screens (PArtCell)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany,Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1994956.0
EU funding (EUR): 1085250.0
Participants: 2
Project status: SIGNED

In the crowded cell, nonspecific interactions between biomolecules alter biochemical equilibria. This matrix of weak nonspecific interactions is composed of hydrophobic, electrostatic, H-bonding, van der Waals, and steric interactions, and is “the dark matter of biology”. Inaccurate prediction of the behaviour of biomolecules inside cells hampers drug discovery: A high throughput drug screen against a purified target protein in dilute buffer ignores the presence of these weak interactions and results are less relevant. High throughput screens directly in cells are however more difficult to control, interpret and measure. PArtCell provides a key advance by combining the high level of control and ease of high-throughput screening on purified proteins, with the relevance of screening in the native environment. The aim is to construct artificial cells that provide a physiologically relevant drug-screening platform. We will achieve this aim by constructing artificial cells with a matrix of weak nonspecific interactions akin living cells as verified with newly engineered fluorescent probes. The probes measure hydrophobicity, electrostatics and steric effects, as well as the physicochemical state of pathogenic condensates, in healthy and stressed living cells. With this information, we will benchmark artificial cells. Drug screens are applied against pathogenic oligomers that we now can observe in these well-characterized artificial cells. This research will update textbook knowledge and provide the molecular origin of the matrix of weak nonspecific interactions in living cells. It provides a platform that allows screening against targets under native-like conditions not achievable with other methods. This research thus provides a new opportunity to screen drugs against diseases for which we have no cure yet.

Keywords: genetically encoded fret sensors,macromolecular crowding,biochemical organization,artificial cells
Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma. (EDIT)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Israel,Italy,Greece,Netherlands,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-10-01
End date: 2022-09-30
Duration (months): 48.0
Total project cost (EUR): 4317160.0
EU funding (EUR): 4317160.0
Participants: 10
Project status: SIGNED

Unmet clinical needs in the management of bladder cancer (BCa) are the prevention of tumor onset, relapse and progression, and therapy of the aggressive carcinoma in situ (Cis), requiring weekly treatments and endless follow-up, with a consequent poor quality of life and the highest cost per patient among all cancers. Therefore, public health programs crave for early BCa detection protocols, to improve performance in the management of this devastating disease. Here we propose an advanced transformative technology termed EDIT combining a novel high-resolution ultrasound elastography and photoacoustic imaging on the bladder instilled with targeted plasmonic gold sensors. EDIT approach exploits the structural and mechanical properties of the bladder extracellular matrix (ECM) as a unique biomarker of the early onset/progression/relapse of carcinoma, through engineered novel gold nanorods (GNRs) used as intravesical photoacoustic antennas targeted at the ECM, generating an ad hoc visualization platform. GNRs will be further utilized as heat-releasing effectors at nanoscale for targeted cancer photo-thermal therapy. EDIT is designed to detect pre-neoplastic area and eradication of local areas at few cells resolution with high sensitivity and specificity. We bring together a multi and transdisciplinary consortium capable to develop non-invasive and non-ionizing novel technology and preclinical validation for early prognosis of BCa and therapeutic nanomedicine against bladder Cis. Outcomes of EDIT will revolutionize the management of BCa with the introduction of sensing and effector nanotechnologies combined with non-invasive organ imaging with high resolution/definition by 3D ultrasound and photoacoustic imaging. Structural and mechanical modification of the ECM is a common denominator for invasive breast, colorectal, prostate and bladder cancers. EDIT platforms will also pave the ways for the earlier management of other bladder-related pathologies and solid tumors.

Keywords: bladder,cancer,nanomedicine,photoacoustic,ultrasound,stiffness,3d imaging
An innovative virtual software-defined mobile packet core to enable optimized and flexible user-centric services for next generation mobile networks (Cumucore)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cumucore is a flexible, modular and efficient virtualized software-defined 4G/5G mobile packet core to help mobile operators dynamically scale up or down their core network based on real network usage and end-user demand. In addition, our software-based network slice manager allows dynamically slicing the network to isolate IoT data from other traffic and to redirect media traffic to MEC functions that include media delivery (media caching or transcoding). Our product solves the need to provide high-speed ultra-reliable Internet connectivity for the growing number of devices (i.e. IoT) together with a reduction in latency and power consumption to support the requirements of massive machine-type communication and mission-critical applications, such as automotive, smart grid, healthcare or industrial automation. Our solution allows mobile operators to reduce up to 50% the traffic in their networks, while supporting maximum traffic performance (> 40Gbps), which serves to solve in few minutes (vs 3-6 months) the scalability and congestion problems of the existing hardware-based core architectures of main network infrastructure providers . Our pay-as-you-go business model is based on in-house development with cloud licensing using B2B channels. Operators will pay based on usage, thus, lowering their initial investment. Cumucore is also a resource-efficient product that will help reduce the energy consumption and carbon footprint in mobile network infrastructure. During the FS we will carry out a technical, commercial and financial feasibility assessment so as to support an efficient Media Broadcasting (AR/VR and gaming) and identify suitable 5G use cases for Phase 2. Commercialization, partnership and IPR issues will also be addressed, together with detailed economic projections and analysis of funding requirements. We have successfully tested our solution in the 5G European market through the execution of projects for niche mobile operators.

Keywords: mobile packet core,network slicing,scalability,congestion,mobile operator,network providers,nb iot,media delivery,gaming,pay as you go