Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DualDur: A Disruptive Diagnostic Technology that Enables for the First Time an Early and Accurate Diagnosis of the tick-borne Lyme Disease. (DualDur)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Hungary
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-04-01
End date: 2020-06-30
Duration (months): 27.0
Total project cost (EUR): 3507750.0
EU funding (EUR): 3507750.0
Participants: 1
Project status: CLOSED

Lyme borreliosis (LB) is the most common zoonotic disease in Europe with 650-850,000 estimated cases. Currently used serological tests for Lyme disease are highly unreliable in early stages of the infection, showing 17-40% sensitivity. If the disease is not diagnosed and treated early on; the infection often spreads to joints, the nervous system, and the heart causing severe and potentially persisting symptoms. Late stage, disseminated LB is a heavy burden on the patients in terms of quality of life and direct and indirect costs. It is also a significant burden on the European healthcare system: the majority of the €1 billion annual cost of the disease is associated with late stage LB. Our patented DualDur reagent and method enables a more reliable early diagnosis of Lyme disease than currently used serological methods, as it is based on direct detection of the bacteria and does not rely on the immune response. So far used as a supplementary testing method mainly at research institutes, in the present project we aim to validate a novel testing procedure based on software-aided microscopy. This will allow the wide-spread application of DualDur, as it improves time-to-result by 10 times, and decreases personnel need compared to our current procedure. Our improved reagent and software-aided testing enables us to provide the DualDur tests all over Europe through partnerships with medical laboratories. More reliable early diagnosis of Lyme disease will reduce the number of later stage cases significantly. This in turn will improve the quality of life of patients and reduce the financial burden of the disease, saving approximately € 330 million on healthcare costs in the first 5 years already. DualDur testing targets the €400 million European Lyme diagnostic market. We will be able to capture 5,1% of this growing market by 2024; representing an annual testing revenue of €23 million at our laboratory partners; and an annual turnover of close to €6 million to our company.

Keywords: lyme diagnosis,borreliosis test,tick transmitted disease,vector borne diseases,diagnostic method,emergent diseases,disease surveillance,public health,zoonotic disease
Gut microbiota-Microglia Interactions in NeuroDevelopment (GutMIND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Childhood psychiatric disorders are alarmingly common, yet current gold-standard treatments fall short in creating lasting, meaningful improvements for many individuals. To improve outcomes, it is imperative to enhance our understanding of pathways to disordered development. Recent advances in the study of microglia-neuron interactions and critical period signals suggest that disruption in the developmental timing of these neural events may contribute to early-onset psychopathology. However, the factors that modulate these signals have not been well-defined. The GutMIND project will test the hypothesis that complementary maturation of the microbiota and the brain during critical windows of development may be one contributing factor. For the first time, the (sex-specific) trajectory of the microbiota’s influence on behavioural and neural outcomes during early host development will be characterised in detail. This will generate testable hypotheses regarding potential mechanisms and thus potential treatments to ameliorate the effects of microbiota depletion during critical periods. Specifically, this will be achieved by experimentally testing 1) metabolite pathways that may contribute to the microbiota’s influence on microglia-neuron communication and 2) the mediating role of the microglia in microbial influences on behaviour. In line with the objectives of the MSCA fellowships, the research project has been designed to facilitate the applicant’s career development by providing advanced training in supportive host environments that will diversify her research competencies, foster her managerial and teaching skills, and strengthen her research profile and professional network. In the process, public, industry, and scientific audiences will be engaged in the outcomes of the action through a multi-pronged communication, dissemination, & exploitation strategy that will promote positive mental health development in the EU and beyond.

Keywords: brain gut microbiota axis,microbiome,neurodevelopmental disorders
Gliders for Research, Ocean Observations and Management: Infrastructure and Innovation (GROOM II)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Ireland,Cyprus,Norway,Sweden,Switzerland,Finland,Greece,France,France,France,France,Netherlands,Portugal,United Kingdom
Call: Design Studies (H2020-INFRADEV-2019-3, 2019)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 3075037.5
EU funding (EUR): 3075037.5
Participants: 18
Project status: SIGNED

Underwater and surface drones, in particular gliders, have become essential vehicles to carry scientific payloads for most environmental observations from the surface down to 6000m and for activities supporting the blue economy. Their major advantages are being mobile, steerable, persistent and usable in large numbers and at relatively low costs. However, the distributed infrastructure required to exploit these assets must be able to meet different demands from research and monitoring of the marine environment, to public service missions and industry needs, requiring customised payloads and operations. The rapid evolution of such technologies (robotics, artificial intelligence, sensors, big data) requires that the R&D resources offered by this distributed infrastructure continuously adapt to users’ demands. The complex hardware and information technology characteristics of such a distributed European infrastructure, optimizing access to resources and R & D for gliders, were analysed during the GROOM-FP7 design study from the perspective of research and the Global and (future) European Ocean Observing System (GOOS & EOOS) needs. Since then, several “gliderports” have developed which has fostered a corresponding European industrial innovative sector. GROOM II, building on its predecessor, will deliver the decision basis for an advanced MRI that promotes scientific excellence, fosters innovation, support the blue economy, builds industrial and public partnerships, and works towards helping achieve the common research and innovation mission for future Europe. The project will define the overall organization of an infrastructure dedicated to ocean research and innovation, and maritime services supporting Blue Growth. This infrastructure will be a positive step against today’s fragmented European landscape, aiding connections and synergies for the completion of GOOS and EOOS.

Keywords: underwater glider,autonomous unmaned vehicle,ocean observing systems,fair,marine robotic and innovation,blue economy,marine research infrastructure
POND Ecosystems for Resilient FUture Landscapes in a changing climate (PONDERFUL)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Uruguay,Germany,Spain,Spain,Switzerland,Türkiye,Belgium,Sweden,France,Denmark,United Kingdom,United Kingdom,Denmark,United Kingdom,Portugal
Call: Inter-relations between climate change, biodiversity and ecosystem services (H2020-LC-CLA-2019-2, 2019)
Start date: 2020-12-01
End date: 2024-11-30
Duration (months): 48.0
Total project cost (EUR): 6993407.5
EU funding (EUR): 6993407.5
Participants: 18
Project status: SIGNED

Ponds and “pondscapes” (networks of ponds) are crucial for biodiversity conservation and their multiple societally beneficial ecosystem services (ES) provide the means to play a crucial role in mitigating and adapting to climate change. However, ponds are largely neglected in water- and nature-related policies and there is insufficient knowledge on how to manage and restore ponds to maximize their role as nature-based solutions (NBS) to increase resilience of ecosystems and society to climate change (CC). The overarching aim of PONDERFUL is to facilitate improved implementation of ponds NBS for CC mitigation and adaptation, biodiversity conservation and delivery of ES through generating and integrating biodiversity, ecosystems, social, economic and policy knowledge and providing evidence-based guidance and tools for pond NBS implementation. To achieve this, PONDERFUL will: 1) evaluate the interactions and feedbacks between biodiversity, ES and climate in pondscapes at multiple spatial scales; 2) together with stakeholders, develop future scenarios for pondscapes in EU and CELAC in the context of CC, land use change, and changed policies; 3) develop and test the implementation of effective multifunctional NBS in close collaboration with the stakeholders using DEMOnstration sites in EU and CELAC countries; 4) develop a sustainable finance and investment guide for NBS, in collaboration with local stakeholders; 5) assess the potential for large-scale implementation of the proposed NBS in relation to existing barriers, enabling factors, financing and as economic viability, as well as social perceptions of benefits from pond NBS. Ultimately, the stakeholder-oriented approach adopted by PONDERFUL will ensure that the scientific knowledge produced on the benefits of using pondscapes as ecosystems delivering multiple ES is explicitly considered in decision making from local management to EU policies.

Keywords: freshwater ecosystems,climate change mitigation and adaptation,ecosystem services,nature based solutions,policy and social context,stakeholders,sustainable financing,multi actor approach
Meteorological uncertainty management for Flow Management Positions (FMPMet)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Spain,Austria,Germany,Spain,Croatia,Sweden,Croatia
Call: Environment and Meteorology for ATM (H2020-SESAR-2019-2, 2019)
Start date: 2020-05-01
End date: 2022-10-31
Duration (months): 30.0
Total project cost (EUR): 849000.0
EU funding (EUR): 849000.0
Participants: 9
Project status: CLOSED

This project addresses the topic “Environment and Meteorology for ATM”. The framework for this project is the integration of meteorological forecast uncertainty information into the decision-making process for Flow Management Position (FMP). FMP is an operational position located in Area Control Centres (ACC) which serves as an interface between Air Traffic Control (ATC) and the Network Manager (NM) Operations Centre. FMP monitors the level of traffic in ATC sectors, adjusts the value of capacity in view of unexpected events, and coordinates possible traffic flow measures with the ACC Supervisor and the NM when an excess of demand over capacity is detected. The presence of storms challenges ATC: it makes the sector demand not easy to predict and increases the complexity, thus reducing the sector capacity. The overall objective of FMP-Met is to provide the FMP with an intuitive and interpretable probabilistic assessment of the impact of convective weather on the operations, up to 8 hours in advance, coming from the combination of the probabilistic sector demand, complexity and capacity reduction, to allow better-informed decision making. FMP-Met has the following specific objectives: Tailor multi-scale, multi-source convective weather information for FMP application; forecast multi-sector demand and complexity under convective weather; translate convective weather forecasts into predictions of reduced airspace capacity; and produce guidelines on the use of probabilistic forecasts for FMP application. The expected impact of this project is the enhancement of ATM efficiency by improving decision making in traffic flow management under convective weather. The provision of a trustworthy forecast of the future sector demand and of a reliable estimation of the impact of the convective weather in the sector capacity will support the FMP in taking anticipated, appropriate, and timely tactical flow measures, which as a consequence will lead to a reduction of delays.

Keywords: adverse weather,thunderstorms,weather forecast uncertainty,aircraft trajectory analysis,sector demand,sector complexity,sector capacity,flow management position,air traffic management
ProGeo (ProGeo)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy,Italy,Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2015, 2015)
Start date: 2016-06-01
End date: 2019-05-31
Duration (months): 36.0
Total project cost (EUR): 3493750.0
EU funding (EUR): 2443875.0
Participants: 4
Project status: CLOSED

PLC System is an Italian medium company acting as a EPC and/or supplier for electrical plants/substations engineering and construction and as a IPP (independent power producer). The high technical and managerial capacity allowed to PLC to reach a consolidated position in the European energy sector, with a 2015 turnover of 35 M€ and a 85 figures staff, mainly composed by engineers and high level technicians. PLC is very active in the energy R&D, with the clear scope to fabricate and install its own products to be offered in the very competitive energy market. Within this framework, PLC developed ProGeo, a 500 kW Power-to-Gas modular unit able to store electricity by converting carbon dioxide (CO2) into synthetic methane (CH4) with high flexibility thanks to fast start-ups and shut-downs. The patented product will be offered to owners and managers of small Thermoelectric Generation (s-TEG, < 50 MWth) plants, who will have the possibility to store energy and avoid the sale of low-price electricity during low peak requirements (electricity market price < 20-30 €/MWh) and to reduce the CO2 emissions and the consequent carbon tax amount (5 ÷ 20 €/ton of CO2), producing an additional revenue source from the synthetic-CH4 generation. ProGeo will provide customers with the following benefits: • increasing of average electricity sale price = +25% • reduction of CO2 emission and tax = -10% • increasing of TEG plant EBITDA = up to 1 M€/y for a 20 MWel natural gas fuelled power plant • ProGeo pay-back time = 3 ÷ 4.5 years • reduced start-ups / shut-downs of the TEG PLC has developed a pilot prototype of 30 kWel, by which the technology potentialities have been demonstrated, has identified a strategic partner (LAMEP, a company operating in the field of precision engineering) and has defined a business plan with the assessment of the minimum viable product (MVP), the production cost and market price, a preliminary industrialization and commercialization plan.

Keywords: co2 valorization,power to gas,sabatier reaction,electricity storage
RECOVERY OF DISCHARGED FRACTIONS OF PET RECYCLING PROCESS (HORTAPPET)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

PETRA POLIMERI s.r.l. was born in 2000 to develop its activities in the field of Polyethylene terephthalate selection and recycling, mainly for food applications, transforming 15,000 tonnes/year. We have developed an innovative technology able to recover the secondary fractions of PET recycling, 15 % of the recycled product, which up to now have been no recyclable and send to incineration or landfill. We have designed a multilayered R-PET sheet structure, HORTAPPET, having the outer layers made with a co-polyester with a glass transition greater than 95 ºC, and a central layer of R-PET (secondary fractions) thermoplastic material. HORTAPPET achieves a heat resistance up to 80 ºC, a reduction in its fragility, a notable transparence, and a lack of contaminants, what helps it to be 100% recyclable itself. Our product will be commercialized at a price 20% cheaper than other conventional solutions. This new business opportunity is expected to reach about 7,5 MLN € after 5 years of commercialization. The payback of the expected investment of this project, 1,2 MLN €, will be reached during the 3rd year. This innovative product is aimed to be sold in the horticultural market, and final users are mainly growers and greenhouse managers. Our main commercial barrier will be to gain presence in the international horticultural market as this is a new sector for us. In order to overcome this barrier, promotional activities will be essential. Our project is in line with the circular economy as it promotes the efficient use and recycling of the off grade fractions of R-PET promoting the development of new market applications. HORTAPPET is the best option for horticultural applications because it has better mechanical and visual properties than R-PS and R-PP. Besides, it is cheaper due to the fact that it is made of discharged fractions of PET recycling process. R-PET couldn’t be used in this field due to its high price and its low heat resistance.

Keywords: recycling,horticultural,secondary fraction,seedling tray,post consumed
Smart capture phases for proteomics, glycomics and biomarker assays (BioCapture)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,South Africa,Germany,Norway,Sweden,Sweden,Sweden,Norway,Sweden,Denmark,Denmark,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-11-01
End date: 2021-10-31
Duration (months): 60.0
Total project cost (EUR): 2982872.07
EU funding (EUR): 2982872.0700000003
Participants: 14
Project status: CLOSED

The overall objective of BioCapture is to develop novel robust assays for proteinaceous biomarkers associated with cancer and to develop innovative tools for assaying elusive cancer related posttranslational modifications in proteins. This will be achieved by exploiting robust glycan, peptide and protein binders in the form of Molecularly Imprinted Polymers (MIPs) or plastic antibodies alongside generic enrichment combined with selected reaction monitoring-based mass spectrometry assays. In addition, sequence specific MIPs for multiple proteotypic peptides will be developed for use as capture phases in array format followed by MS or fluorescence based readout as well as a coupling of both detection techniques. The artificial receptors will be developed by various Molecular Imprinting techniques. The research results will lead to technological advances having a major impact on 1) health care since it will profit from methods for earlier, more reliable diagnosis of diseases, 2) drug discovery allowing a faster target or biomarker identification; and 3) biochemistry research laboratories in resulting in improved protein fractionation tools for revealing low abundant post translational modifications. The training of researchers will be performed by a consortium consisting of in total 15 partners whereof 6 polymer/materials research groups, 5 protein/glycan chemistry/analysis groups, 1 separation technology companies, 2 expert groups on platforms for multiplex analysis and one diagnostic company. This forms the basis for a very exciting interdisciplinary training program. Thus 11 early stage researchers (ESRs) working on specific tasks within five work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.

Keywords: molecular imprinting,posttranslational modification,phosphorylation,proteotypic peptide,glycosylation,fluorescence sensor
Unifying Neutrino Observatories Searches (UNOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2024-04-29
Duration (months): 30.0
Total project cost (EUR): 204415.68
EU funding (EUR): 204415.68
Participants: 2
Project status: SIGNED

One of the main unknowns in Particle Physics is the mechanism behind masses and mixings in the neutrino sector. Consequently, it is natural to view neutrinos as a window to New Physics. Beyond the Standard Model (BSM) models explaining the masses and mixing parameters often predict new generation(s) of neutrinos and novel types of interactions with matter, known as Sterile Neutrinos (SN) and Non Standard Interactions (NSI) respectively. The objective of this proposal is to experimentally test those predictions, thereby elucidating the fundamental nature of neutrinos. In fact, by measuring and characterising the flux of atmospheric neutrinos, neutrino telescopes can experimentally constrain SN and NSI models, and hence Unifying Neutrino Observatories Searches (UNOS) is a unique project that aims to search for those BSM candidates. Neutrinos are distinctive particles as they interact very weakly, so they can transit long paths through the Earth. Cosmic-ray-induced air showers produce those particles in the atmosphere over a wide energy range, providing a "naturally" occurring flux that cannot be produced in any man-made neutrino beam. Actually, in 2015, the discovery of neutrino oscillations studying atmospheric (and solar) neutrinos, was awarded Nobel Prize in Physics. Neutrino telescopes consist of a grid of optical sensors placed several kilometres under water or ice. Neutrinos are detected by capturing the Cherenkov light induced by the charged particles produced by neutrino interactions in the medium. UNOS will exploit four of those detectors constructed by two international collaborations, IceCube and KM3NeT, to provide world-leading constraints on SN and NSI models. Harvard University and Universitat de Valencia will join efforts to support and train Dr. Garcia throughout this ambitious enterprise.

Keywords: neutrino telescopes,sterile neutrinos