Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Research Infrastructures - Pathway to Improved Resilience and Digital and Remote Access (eRImote)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Norway,United Kingdom,Ireland,Italy,France,Finland,Sweden,Switzerland
Call: Transition to digital/remote research infrastructure service provision: lessons learnt, needs and best practices (HORIZON-INFRA-2021-DEV-01, 2021)
Start date: 2022-06-01
End date: 2024-11-30
Duration (months): 30.0
Total project cost (EUR): 1429880.0
EU funding (EUR): 1429877.0
Participants: 13
Project status: CLOSED

The eRImote project is the first to consider solutions for digital and remote service provision across RI domains and to look for transferable practices and new developments that will improve accessibility and resilience of RI infrastructures. While existing processes will be collected, eRImote will also explore new solutions using defined use cases to develop and test their implementation in RI scenarios. This will take us beyond the state-of-the-art for concrete solutions. The eRImote consortium is relatively small with eight beneficiary participants representing four main ESFRI RI Roadmap domains. However, the consortium extends much more broadly through the existing contacts and networking partners of each of the project participants, increasing the reach out to hundreds of individuals, other European and global RIs, scientific networks, RI users, industry partners and policy makers. eRImote is intended for 30 months to enable timely interventions. The project is outlined relatively straightforward by four main activities. eRImote will create an online information platform with a publicly available data store on best practises and tools based on a landscape analysis, also with needs and impact. This will be translated into strategies on transition and use cases (Green Paper). All this is based on broad outreach and extensive dissemination beyond the consortium. The eRImote consortium will identify strategies and solutions to enable transition to remote and digital access to RI services that will help to enhance and make more accessible the service capacities of RIs while reducing the need for physical access to RI sites, bringing benefits to the green economy, reducing the footprint of RIs and increasing their inclusiveness as a result. In addition, eRImote will contribute to increased efficiency of remote access service provision at RIs, enhance mutual knowledge and trust, and develop joint strategies across the RI domains on transition to

Keywords: digital and remote access,digital and remote service provisions,research infrastructures,online knowledge database,best practices strategies for transition
A bio-inspired self-dislodging approach of ice (BSAI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2026-08-31
Duration (months): 12.0
Total project cost (EUR): 97037.28
EU funding (EUR): 97037.28
Participants: 1
Project status: SIGNED

Novel and efficient anti-icing/de-icing methods should be continuously explored because ice accumulation has dramatic adverse effects on human activities. Traditional thermal de-icing, as an active technique extensively used in the industry, requires enormous energy input and may deteriorate the functionality of wall material such as epoxies or resins if the temperature is too high. Passive de-icing methods cannot work alone for safety concerns, although they do not require external energy inputs. Therefore, there is an urgent need to integrate the active de-icing method with the passive one, leading to a hybrid anti-icing/de-icing approach. Inspired by natural creatures who usually use their surface structures to realize directional liquid transport for survival, a spontaneous self-dislodging approach of ice is proposed by artificially varying the surface wettability without external energy input. The de-icing performance of this method can be further enhanced by imposing a temperature gradient. Compared with the traditional thermal de-icing method, the required de-icing time can be reduced by more than 90% based on the applicant’s test cases of this novel hybrid anti-icing/de-icing method that has not previously been proposed. A mathematical model that will be validated by performing Molecular Dynamics (MD) simulations will be built to quantify the effects of wettability and temperature variations on the de-icing performance of this novel method. This work will shed light on the design of intrinsically icephobic materials.

Keywords: anti icing de icing,molecular dynamics simulation,hydrodynamics,thermaldynamics
The Silent Phase of Alzheimer’s Disease: From Brain States to Homeostatic Failures (DormantAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Neuronal circuits must balance stability and plasticity. How this balance is compromised in brain disorders remains one of the most fundamental questions in neuroscience. Pioneering studies in the field established that homeostatic mechanisms stabilize the function of a system at a set-point level of activity. Recently, we have identified bona fide mitochondrial regulator of activity set points and provided support to our standing hypothesis that homeostatic failures destabilize network activity in Alzheimer's disease (AD). However, we have just scratched the surface of the mechanisms stabilizing activity set points in vivo. I propose a conceptual and experimental framework to identify the cellular-molecular and circuit-wide in vivo mechanisms underlying stability of hippocampal circuits across distinct brain states and stability-plasticity balance. Using a wide range of optical, electrophysiological, computational and molecular tools, we will explore homeostatic regulation of activity in hippocampal circuitry, a crucial substrate for memory formation, and its relation to AD. First, we will establish governing principles of homeostatic regulation in physiological context of sleep and learning. Next, we will explore the underlying molecular drivers of homeostatic regulation. Finally, we will test the causal relationship between dyshomeostasis of activity in hippocampal circuits, sleep disturbances and cognitive decline in AD models. To target these questions, we will utilize the basic concepts of control theory and an integrative approach which spans brain-state, neural circuit, synaptic and molecular levels. We believe that this understanding is an essential step to uncover the principle basis underlying the transition from a presymptomatic disease stage to clinically evident cognitive AD impairments. The proposed research will elucidate fundamental principles of neuronal function and reveal conceptually novel insights into how to maintain AD in a dormant state.

Keywords: homeostatic plasticity,synaptic transmission,synaptic plasticity,firing rate homeostasis,hippocampus,electrophysiology,calcium imaging,mitochondria,alzheimer s disease
Responses of cetAceans to natural and anthropogenIc Noise (RAIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

In the marine environment, motorised vessels are now the most ubiquitous and pervasive anthropogenic noise source, and the evidence for deleterious impacts from this noise source on sensitive marine life, such as cetaceans (whales, dolphins and porpoises), is mounting. However, cetaceans have not evolved in silent or naturally quiet environments, and it may be hypothesised that animals have developed mechanisms to cope with naturally fluctuating noise levels. Regardless, studies have yet to investigate whether individual cetaceans perceive and respond to motorised vessel noise in the same way as acoustically similar and significant natural noises, such as rain, for which they have been exposed to over evolutionary timescales. In RAIN, I will, for the first time, compare the responses of harbour porpoises, a small odontocete cetacean, to both motorised vessels and rain noise. RAIN will (1) quantify the absolute contributions of rain and vessel noise to local marine soundscapes experienced by populations of harbour porpoises using long-term passive acoustic monitoring data; (2) assess and compare the behavioural and acoustic responses of individual harbour porpoises to these noise sources using state-of-the-art acoustic recording tags (DTAGs); and (3) investigate the effect of rain and vessel noise on individual echolocation performance as a proxy for foraging performance. Through RAIN, I will provide new insights into how harbour porpoises perceive and respond to natural and anthropogenic noises at population and individual scales, and identify, quantify, and compare potential coping mechanisms they employ to deal with these different noise sources. Results from RAIN will, in turn, providing evidence which will be used to directly inform the management of underwater noise levels and the protection of a key marine species in European marine waters.

Keywords: marine mammals,cetaceans,odontocetes,harbour porpoise,noise disturbance,acoustic behaviour,shipping noise,rain noise,biologging
HIF-1α in Cancer-Associated Fibroblasts: Unveiling implications for the tumor microenvironment and therapeutic strategies (HifCAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Luxembourg,Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Despite significant advancements in understanding CRC pathogenesis, the clinical prognosis of CRC patients is still poor due to metastasis dissemination. Cancer progression is often associated with the presence of cancer-associated fibroblasts (CAFs) in the tumor microenvironment that regulate processes such as extracellular matrix (ECM) deposition and repression of the immune response. The establishment of a hypoxic environment and activation of its main effector, the hypoxia-inducible factor-1α (HIF-1α), are common features of advanced cancers. HIF-1α is a transcription factor, which regulates several genes that are exploited by tumor cells to escape from a nutrient-deprived environment and to survive as well as resist to treatment. However, the role of HIF-1α in CAFs has not be addressed so far in CRC. This research seeks to elucidate the effects of hypoxia on different aspects of CAFs' function , using in vitro functional assays and innovative co-culture models with patient-derived CAFs and matching tumor organoids. Furthermore, the study aims to unveil the role of HIF-1α expression in CAFs during tumor initiation and progression using a colitis-associated carcinogenesis model and pinpoint the origin of HIF-1α+ CAFs employing a lineage tracing model. Finally, in silico analysis of scRNAseq data will allow to detect the subset of CAFs that are responsive to hypoxia in different stages of carcinogenesis and in metastatic dissemination. Overall, this project will study the unappreciated role of HIF-1α in CAFs in the context of CRC with the ultimate goal to pave the way to new therapeutic strategies.

Keywords: colorectal cancer cancer associated fibroblasts tumor microenvironment,cafs tumor cells cross talk hypoxia,hif 1a,scrna sequencing,human derived cafs and matching tumor organoids culture
Titanium-organic framework membranes for CO2 capture (PORECAPTURE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The continued growth in emissions of greenhouse gases in the atmosphere is a pressing issue for our society. The urgent need for strategies to reduce greenhouses gas concentrations has aroused international action from governments. Carbon capture and storage technologies (CCS) have been considered a key solution to reverse the current CO2 trend because they can mitigate, or at least delay, the alarming greenhouses effects. However, the most effective solution for post-combustion CO2 remains still the chemisorption in aqueous solutions of alkanolamines despite limitations as low selectivity, corrosiveness and high energy requirement for operation and maintenance. Membranes are arguably an attractive technology for CO2 removal from mixed, humid gases as it is a relatively simple technology, that can be easily replaced and requires minimum investment and operation costs. In this regard, mixed-matrix membranes incorporating Metal-Organic Frameworks (MOFs) as crystalline components are an excellent alternative to overcome two of the major limitations of polymer-based membranes: swelling and low selectivity towards CO2. Among the families of titanium-organic frameworks developed in the ERC Stg grant Chem-fs-MOF (714122), one of our patented materials (MUV-10) represents a significant improvement or meets the specifications of benchmark materials in terms of key properties relevant to CO2 capture in wet conditions as: gravimetric uptake, adsorbate selectivity, energy efficient sorbent regeneration and recyclability in humid environments. With PORECAPTURE we intend now to explore the commercial potential of this material across three main goals that will include: 1. Optimizing its production at multi-gram scale, 2. Fabricating a new generation of membranes for energy efficient CO2 capture that will be tested in operational environments, and 3. Defining an optimal business model strategy that will include validating our know-how with licensors of CCS technologies.
Violence and Labour Discipline in Early Modern Britain (VIOLLAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

A 2010 report by the European Agency for Health and Safety at Work (EU-OSHA) notes that work-related violence is a ‘serious issue’ facing workers today. It also results in ‘substantial’ economic losses, through workers’ demoralized absenteeism and reduced productivity. Work-related violence, however, is not a new phenomenon; it has a history. VIOLLAB seeks to provide the first analysis of the causes and consequences of one type of work- related violence in Britain, c. 1550-1800: disciplinary violence. It defines ‘disciplinary violence’ as fatal and non-fatal physical violence (e.g., beatings) that employers or managers used to correct workers’ infractions and to instil a sense of discipline in them. Combining methods from social, economic, and labour history with analytical insights from the sociology of work, VIOLLAB uses a range of sources to shed new light on how disciplinary violence influenced contemporary practices and theories of labour management; (gendered and aged-based) experiences of work; and the legal system's mediation of worker-employer relations. By analyzing the causes and consequences of disciplinary violence across different sectors of the British economy as it was transitioning to agrarian and industrial capitalism and becoming increasingly reliant on unfree labour for the production of colonial commodities, VIOLLAB aims to make transformative contributions to scholarship on work, labour relations/discipline, and the law in a period before the existence of modern labour protection laws and workers’ organizations, and to raise public awareness about problems of work in the 21st century.

Keywords: early modern history labour history labour relations legal institutions work
A Learning-from-Prices view of Inflation and Business Cycles (LearnInCycle)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1147981.25
EU funding (EUR): 1147981.0
Participants: 1
Project status: SIGNED

The Eurozone is currently facing a sudden and sharp increase in inflation. Whether inflationary pressures will persist and what will be the cost of an eventual monetary tightening crucially depends on inflation expectations. The aim of this project is to provide theoretical and empirical support to a new channel, through which inflation may persistently shift business activity. The project sheds new light on how market prices influence consumers’ perceived inflation and how this may allow for the transmission of monetary policy even in the absence of rigidities in firms’ pricing. It shifts the focus from a traditional firm-centric to a (complementary) household-centric view of money non-neutrality. It shares the spirit of a recent trend in central banks’ efforts in getting a better appraisal of the importance of consumers’ expectations, after decades of a strict empirical focus on firms’ pricing. The project consists of five working packages (WP) based on the idea that households’ inflation perceptions, driven by actual market prices, can be a major source of the business cycle. The first WP proposes a new theory where output-inflation co-movement relies on consumers’ price hunting in response to perceived inflation, causing a counter-cyclical gap between posted and paid prices inflation. The second and third WP aim at validating the mechanism using large datasets on consumers’ spending and retail trade. The fourth presents a new model where consumers learn from inflation about future economic prospects on which all have dispersed foresight. The fifth will estimate this model on survey data. The key novelty of the project is studying, not only how expectations move market outcomes, as typical in the literature, but also how these feed-back to expectations through prices in a full circle of general equilibrium implications. As by-product, it identifies measurable empirical counterparts for incomplete information sets.

Keywords: inflation information frictions market prices,inflation expectations,business fluctuations,search,learning,information and knowledge,communication,belief,unawarness monetary policy central banks and their policies market structure,firm strategy,and market performance
Enhancing Europe's readiness for managing fall armyworm, an invasive pest threat (EUFAWREADY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: France,Spain,Israel,Netherlands,Italy,United Kingdom,Bulgaria,Greece,Romania,Portugal,Germany,Korea, Republic of,Switzerland,New Zealand
Call: Spotlight on plant priority pest: fall armyworm (Spodoptera frugiperda) (HORIZON-CL6-2024-FARM2FORK-03, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 5013180.0
EU funding (EUR): 4999880.0
Participants: 26
Project status: SIGNED

The fall armyworm (FAW) is a highly invasive and polyphagous pest native to the Americas, first detected in Africa in 2016 and which has since spread globally, including western Asia. By late 2023, FAW had reached mainland Europe, with detections in Greece and Romania. This pest now presents a major threat to European agriculture, as climate change and increased trade increase the likelihood of its establishment or presence across wide areas of Europe. The aim of EUFAWREADY is to provide European agricultural stakeholders—including farmers, advisors, and phytosanitary services—with the tools they need to respond quickly and effectively to potential FAW outbreaks. This involves tools to detect the presence of the pest the earliest possible and to effectively and sustainably manage the pest, thus minimizing the economic, environmental and social impact and the reliance on synthetic pesticides. The specific objectives of EUFAWREADY are to: i) Raise awareness and improve stakeholder preparedness regarding FAW risks, and enhance their engagement in management efforts; ii) Generate new knowledge on the biology of European FAW populations, focusing on traits that enhance their invasiveness potential; iii) Assess the economic and environmental impacts FAW could have on Europe; iv) Provide effective strategies for early detection and monitoring of FAW; v) Investigate a diversified array of sustainable control options that could be offered to European farmers, including the use of FAW natural enemies, microbial agents, and plant-based and natural semiochemical solutions; vi) Integrate these management strategies into guidelines intended to plant health actors, and an IPM toolbox to be provided to European farmers and advisers; vii) Ensure the project's scientific and technical findings are widely shared, so stakeholders are fully informed on FAW risks and management strategies by the project's end.

Keywords: insect crop pest,spodoptera frugiperda,preparedness,economic impact,surveillance,detection,biological control,maize,environmental impact,community building,stakeholder engagement