Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Translational Traditions and Imaginaries: A Comparative History of Petrarch’s Canzoniere in French and English (FR and ENG Petrarch)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-30
End date: 2022-10-16
Duration (months): 36.0
Total project cost (EUR): 253110.72
EU funding (EUR): 253110.72
Participants: 2
Project status: CLOSED

The main objective of the project is to offer a comparative study of early modern translations of Petrarch’s Canzoniere in English and French, as well as examining their impact on their respective ‘translation traditions’. First, I aim to clarify the features of European Petrarchism by focussing on its translational origins in two of the most influential European languages and cultures of the time (besides Italian). My second goal is to establish, from a comparative perspective, the place of Petrarch’s Canzoniere in the ‘culture of translation’ of early modern British Isles and France, in other words, all the modes and conceptions of translation in these linguistic spaces. My third objective is to identify the impact of early modern ‘translational imaginaries’ of Petrarch’s Canzoniere (that is to say, conceptions and representations of Petrarchan poetry in translated texts) in subsequent centuries, thus tracing their ramifications in these two interlinked literary cultures. The University of Montreal (UdeM) is the ideal environment to achieve this ambitious outcome and to improve my skills in translations studies during the first two years of the Fellowship. My supervisor Prof. Marie-Alice Belle, and the research team directed by her, ‘Trajectories of Translation in Early Modern Britain, 1473-1660: Routes, Mediations, Networks’, will provide me with crucial expertise in the study of paratexual materials and cultural networks involved in translation exchanges between France and the British Isles. During the last year, Prof. Venturi, in collaboration with his interdisciplinary research group ‘Textual Traditions and Communities in Early Modern Europe’ at the University of Oslo (UiO), will bring his philological expertise to the project and, under his supervision, I will be able to explore other aspects of the European reception and interpretation of the Canzoniere, including the commentary traditions and circulations of editions with paratexts.

Keywords: translation history,translation studies,reception studies,petrarch,petrarchism,commentary tradition,translation tradition,french literature,english literature,italian literature,medievalism
New Horizons in C–H Activation: the ‘Real-World Molecules’ Challenge (RuCat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2498960.0
EU funding (EUR): 2498959.0
Participants: 1
Project status: SIGNED

A 2018 joint report from pharma identified organic synthesis as one of the major bottlenecks in drug discovery today. In the highly competitive discovery environments, only fast-to-synthesise molecules are targeted, based mostly on five well-tested and proven synthetic methods. This approach has led to only a small portion of the chemical shape space being explored over the last decades and has been partly blamed for the recent low success rates in new drug development. The report emphasises the need for ideal tools such as late stage functionalisation, which would allow simply replacing any C‒H bond in a bioactive molecule with any desired functionality, thus greatly accelerating the synthesis of new candidates from a lead compound. However, the field of C‒H activation is significantly behind in achieving this aim: most biologically active molecules contain several polar and/or delicate functionalities (‘real world’ molecules), whereas most C‒H activation methods use harsh conditions, incompatible with delicate groups, and catalysts that tend to poison in the presence of polar groups. This ERC Advanced Grant addresses this major challenge by building a new tool-set of ruthenium catalysts that will finally be able to deliver late stage functionalisation on ‘real world’ molecules, thus allowing a new dawn for development not only of new drugs, but also of agrochemicals, aromatic based organic materials and associated areas. The project builds on a recent key mechanistic breakthrough by the PI's group on the operation of Ru-catalysts (Nature Chemistry 2018) that reveals a completely different pathway to catalyst design from that followed in the field in the last two decades. This new class of catalysts presents unprecedented high reactivity and compatibility with sensitive ‘real world’ molecules. The PI is in a unique position to capitalize on this discovery and lead the way towards global late stage functionalisation of ‘real world’ molecules.

Keywords: late stage functionalisation,c h activation,homogeneous catalysis
Personalised Pancreatic Cancer Vaccination Therapy derived from Autologous Tumor Cells and Neoantigens (PanCaVax)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CyTuVax B.V. is a biotech enterprise founded in Maastricht (the Netherlands) in October 2012. It applies depot-formulated cytokines (interaction molecules of the immune system), which enhance immune responses in an unprecedented manner when used in extremely high local density. Single and multi-cytokine combinations can be formulated by simple procedures and act as strong adjuvants, driving immune responses to their limits. It is a universal, patented platform adjuvant technology that can be applied to any vaccines and can have great influence on future vaccine technology. CyTuVax achieved the first clinical proof of concept in a Phase I trial in which 90% of hepatitis B non-responders were successfully vaccinated. Phase II is on-going. CyTuVax decided now to focus on the challenging problem of developing a vaccine for pancreatic cancer, a deadly disease for which no curative treatment exists. Its cancer vaccination therapy (PanCaVax) should substantially improve the life-expectancy by extending the median survival rate to at least 12-24 months. Costs of PanCaVax will be considerably less compared to checkpoint inhibitor antibodies, with locally strong, but systemically mild, side effects expected. CyTuVax’ highly motivated team’s next step is to complete the preclinical development of PanCaVax. Key impact of our innovation would be that it is providing a favorable clinical outcome and sufficient proof of efficacy to obtain financial resources for next steps in Phase IIb/IIIa, regulatory approval and ultimate access to pancreatic cancer patients currently lacking an acceptable therapy.

Keywords: cancer,pancreas,neo antigens,clinical trial
ACES: Air Cargo Explosive Screener (ACES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Spain
Call: Critical infrastructure protection topic 7: SME instrument topic: “Protection of Urban soft targets and urban critical infrastructures” (H2020-SMEINST-2-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 1233328.75
EU funding (EUR): 863330.0
Participants: 1
Project status: CLOSED

The ACES (Air Cargo Explosive Screener) program will be devoted to the certification of a new generation of explosive screeners based on vapor detection, targeting the airport security market for cargo screening. ACES has been developed to identify explosive threats with sensitivity and discrimination power orders of magnitude better than state-of-the-art systems. It is unmatched in its ability to screen large volumes in minutes, such as cargo containers and whole trucks, without disassembly. This line of business is backed up both by a very high social demand and a strong institutional support: explosive screening for aeronautical cargo loaded in passenger aircrafts is mandatory in the EU and nearly all nations. This inspection task is presently executed carried out by X-ray screening, which presents two relevant deficiencies: 1) the cargo load must be broken down into pieces where the maximum side is lower than 120 cm, and 2) a human operator interprets the X-ray image, in order to detect an arbitrarily shaped explosive a few centimeters in size, seen with a depth of 120 cm. In previous years, SEDET has developed an unmatched technology in the area, has been selected as the leading vapor screener developer by several European Union aviation testing Agencies and Israel, and is currently undergoing more thorough evaluations on its way to certification. From the technical perspective, ACES´s vapor detection technology first turns into ions minute quantities of vapor molecules released into the atmosphere by hidden explosives. Then these ions are separated at atmospheric pressure according to their size in a mobility filter (a differential mobility analyzer, DMA), and then by filtering the original ions and their fragments according to their respective masses in the vacuum system of a sophisticated triple quadrupole mass spectrometer (MS). ACES technology is protected by several patents and patents applications, both in the US and the EU.

Keywords: aces air cargo explosive screener
Unraveling Principles of PDZ-mediated Cell Signaling (PDZnet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,Germany,Germany,Sweden,France,France,Denmark,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-09-01
End date: 2020-08-31
Duration (months): 48.0
Total project cost (EUR): 3733514.66
EU funding (EUR): 3733514.66
Participants: 10
Project status: CLOSED

PDZnet will create an innovative European PhD training network focusing on unraveling PDZ domain-mediated signaling networks. The emphasis will be on signaling nodes essential for the development of cancer and diseases of the nervous system, conditions that affect millions of Europeans and are major societal challenges. PDZ domains are protein and lipid recognizing modules that play a central role in trafficking and organizing diverse cell signaling assemblies, thereby allowing information to be transmitted from receptors, ion channels and transporters in the cell membrane. PDZ domain mediated interactions are emerging as conceptually novel and promising drug targets, with exciting opportunities for the development of novel therapies, especially within cancer and brain diseases. We will establish a European multidisciplinary platform integrating a plethora of complementary life science disciplines that range from chemical development of inhibitors to studies in live animals. The network encompasses 8 academic and 2 industrial beneficiaries as well as one industrial and one academic partner, which are all committed to promote frontline research, innovation and educational activities within the study of PDZ domain-mediated signal transduction pathways related to brain diseases and cancer. This interdisciplinary network will establish an outstanding training opportunity for Early Stage Researchers, who will be integrated in projects unraveling intracellular PDZ domain interactomes to provide pertinent information for discovering drug-related interactions. In a comprehensive and integrated training effort, involving a combination of scientific and transferable skills, the students will receive an interdisciplinary, intersectoral and innovative doctoral training from experienced industrial and academic leaders in well-reputed European Institutions.

Keywords: protein protein interactions,protein lipid interactions,pdz domains,signaling,trafficking,cancer,cns diseases,intracellular protein network,pdz inhibitors,synaptic transmission
Functional Optoacoustic Neuro-Tomography (FONT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-07-01
End date: 2017-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The currently available neuroimaging tools, such as functional magnetic resonance imaging (fMRI) and optical microscopy, are not adequate for deep tissue volumetric visualization of brain activity in real time. The need for such solutions underlies the large scale multi-year European Human Brain Project as well as the BRAIN initiative promoted by the US government. Under the currently funded ERC-StG project, we have pioneered the so-called five-dimensional optoacoustic imaging method that can simultaneously render spectrally and temporally resolved volumetric images deep from highly scattering tissues. Taking this achievement one step further, in this PoC grant we propose to prototype and validate a functional optoacoustic neuro-tomography (FONT) scanner specifically tailored for fully noninvasive volumetric observations of activity in whole brains of rodents. In combination with optoacoustics' well-established capacity for resolving vascular anatomy and multiple hemodynamic parameters deep in scattering tissues, this solution will open new vistas in the study of brain activity and development of novel therapies targeting neurological and neuropsychiatric disorders.

Keywords: functional neuroimaging,optoacoustic tomography,brain
ANTICSS - ANTI-Circumvention of Standards for better market Surveillance (ANTICSS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Italy,Germany,Spain,Italy,Germany,Belgium,Czechia,Netherlands,Netherlands,Portugal
Call: Effective implementation of EU product efficiency legislation (H2020-EE-2017-CSA-PPI, 2017)
Start date: 2018-04-01
End date: 2021-09-30
Duration (months): 42.0
Total project cost (EUR): 1961948.75
EU funding (EUR): 1961948.75
Participants: 19
Project status: CLOSED

ANTICSS objectives are (i) to assess and define "circumvention" in order to achieve a better product positioning in relation to EU Ecodesign and Energy labelling legislation and relevant harmonised standards; this includes clear delimitation from other effects to facilitate unambiguous public (media) communication; (ii) to collect, analyse and learn from cases of circum¬vention by literature research and dedicated expert interviews, as well as analysing existing EU Ecodesign and Energy labelling legislation and standardisation for possible loopholes. The potential relation between circumvention and "smart" products with specific embedded software will be also addressed. From these findings, conclusions how to better detecting and preventing future circumvention will be derived; (iii) to assess impacts 'if' and 'how much' energy consumption and/or functional performance modifications could be ascribed to circumvention by conducting appliance testing; (iv) to define alternative test procedures or check lists with the aim to by-pass any possible measurement circumvention; based on the results ANTICSS will ensure sustainability beyond the project life by (v) practical capacity building measures for key actors of market surveillance and test laboratories, (vi) supporting communication and collaboration platforms between major stakeholders and (vii) providing policy recommendations for policy makers and standardisation bodies to prevent future circumvention under EU Ecodesign and Energy labelling. ANTICSS will also provide reliability to manufacturers by specifying potentially vague legislation and standards which might be interpreted differently by market actors and some of them taking unfair advantages so far. By overall awareness raising on circumvention among stakeholders, ANTICSS will be supporting an effective EU legislation enforcement and thus increasing acceptance and trust of market actors and civil society into the Ecodesign and Energy labelling legislation.

Keywords: ecodesign,energy labelling,harmonised standards,measurement methods,presumption of,conformity,circumvention,performance,research,legal provision,data collection,eu member states,product categories
Nonlocal PDEs for Complex Particle Dynamics: Phase Transitions, Patterns and Synchronization (Nonlocal-CPD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-10-01
End date: 2026-09-30
Duration (months): 72.0
Total project cost (EUR): 2478560.0
EU funding (EUR): 2478560.0
Participants: 1
Project status: SIGNED

This proposal focuses on the development of new mathematical tools to analyse theoretical, numerical and modelling aspects of novel applications of nonlinear nonlocal aggregation-diffusion equations in Mathematical Biology and in classical problems of kinetic theory. Among the numerous areas of applications of kinetic modelling in Mathematical Biology, we will concentrate on phenomena identified, at the modelling stage, as systems involving a large number of "individuals" showing "collective behaviour" and how to obtain "averaged" information from them. Individuals behavior can be modelled via stochastic/deterministic ODEs from which one obtains mesoscopic/macroscopic descriptions based on mean-field PDEs leading to continuum mechanics, hydrodynamic and/or kinetic systems. Understanding the interplay between the interaction behaviour (nonlocal, nonlinear), the diffusion (nonlinear), the transport phenomena, and the synchronization is my main mathematical goal. The proposed research is centred on developing tools underpinning the analysis of long time asymptotics, phase transitions, stability of patterns, consensus and clustering, and qualitative properties of these models. On the other hand, designing numerical schemes to accurately solve these models is key not only to understand theoretical issues but also crucial in applications. We will focus on the important case of the Landau equation with applications in weakly nonlinear plasmas by means of the gradient flow techniques. On the other hand, we showcase our tools in patterns and consensus by focusing on zebra fish patterning formation, as example of spontaneous self-organisation processes in developmental biology, and grid cells for navigation in mammals, as prototype for the synchronization of neural networks. This project connects with other areas of current interest in science and technology such as agent-based models in engineering: global optimization, clustering, and social sciences.

Keywords: nonlocal pdes,collective behavior,aggregation diffusions,landau equation,gradient flows,phase transitions
Endodrill® Model X - a new endoscopic biopsy instrument taking multiple cancer samples of varying depth in one single session (Biopsy X)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of this 6-month Phase 1 project is to evolve the prototype of Biopsy X, the new reliable endoscopic biopsy instrument, taking multiple cancer samples of varying depth in one single session, to transform our initial business plan into a robust strategy for international commercialization and to prepare for a Phase 2 demonstration. Our product is the missing link that will bring effective, fast and patient-friendly cancer diagnosis, setting up the new standard for this method. The EndoDrill® Model X is a unique combination of knowledge in mechanical engineering, physics and physiology. Research has been partially funded by Swedish R&D grants from Vinnova as well as from foundations (Sten K Jonsson Foundation, IKEA Foundation) and Lund University Innovation. Since 2017 the company is listed at AktieTorget stock market. Our ambition is to accelerate proper diagnosis progress so that 3 in 4 people will survive cancer within the next 20 years by making sure patients have access to the best, fastest, safe and characterized with ultra-high precision cancer diagnostic method, minimizing at the same time the level of discomfort. BiBBInstruments AB is well-positioned to bring its innovation to the market. The product has been developed and validated by practitioners in close cooperation with Skåne University Hospital in Lund as well as by end-users. This has assured market proximity of all the R&D activities.

Keywords: endoscopy,bronchoscopy,colonoscopy,gastroscopy,esophagoscopy,biopsy instruments,cancer diagnostics,lung cancer,gastric cancer,colorectal cancer