Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microclimatic buffering of plant responses to macroclimate warming in temperate forests (FORMICA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1498469.0
EU funding (EUR): 1498469.0
Participants: 1
Project status: CLOSED

Recent global warming is acting across ecosystems and threatening biodiversity. Yet, due to slow responses, many biological communities are lagging behind warming of the macroclimate (the climate of a large geographic region). The buffering of microclimates near the ground measured in localized areas, arising from terrain features such as vegetation and topography, can explain why many species are lagging behind macroclimate warming. However, almost all studies ignore the effects of microclimatic buffering and key uncertainties still exist about this mechanism. Microclimates are particularly evident in forests, where understorey habitats are buffered by overstorey trees. In temperate forests, the understorey contains the vast majority of plant diversity and plays an essential role in driving ecosystem processes. The overall goal of FORMICA (FORest MICroclimate Assessment) is to quantify and understand the role of microclimatic buffering in modulating forest understorey plant responses to macroclimate warming. We will perform the best assessment to date of the effects of microclimates on plants by applying microtemperature loggers, experimental heating, fluorescent tubes and a large-scale transplant experiment in temperate forests across Europe. For the first time, plant data from the individual to ecosystem level will be related to microclimate along wide temperature gradients and forest management regimes. The empirical results will then be integrated in cutting-edge demographic distribution models to forecast plant diversity in temperate forests as macroclimate warms. FORMICA will provide the first integrative study on microclimatic buffering of macroclimate warming in forests. Interdisciplinary concepts and methods will be applied, including from climatology, forestry and ecology. FORMICA will reshape our current understanding of the impacts of climate change on forests and help land managers and policy makers to develop urgently needed adaptation strategies.

Keywords: climate change,forest ecology,population and community ecology,forestry,functional biodiversity,global change biology,macro ecology,management,statistical modeling
Gene expression level as a keystone to understanding gene duplication: evolutionary constraints, opportunities, and disease (DOUBLE EXPRESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1824793.75
EU funding (EUR): 1824793.75
Participants: 1
Project status: SIGNED

Duplicate genes are important in disease, are a hugely important source of evolutionary novelty, and for many years we thought we understood them. We thought that duplication relieved selective constraints. We thought that gene knockout neutrality was due to redundancy. We thought that a duplicate is a duplicate is a duplicate. Evidence is accumulating challenging each of these views. Rather than being the result of an unbiased process, the genes that tend to duplicate in our genome and others are quickly evolving, non-essential genes, irrespective of current duplication status. Conversely, genes retained after whole genome duplication (WGD) are slowly evolving, important genes. I propose that different resolution of the evolutionary constraints imposed by the demands of gene expression can explain these contrasting relationships. I propose that the opposing constraints on gene-by-gene duplications as compared to WGD channel these different sets of genes into remarkably different evolutionary trajectories. In particular, in much the same way that individual gene duplication creates an opportunity for the evolution of a new gene, the co-evolution of expression of sets of interacting genes after WGD creates an opportunity for the evolution of new biochemical pathways and protein complexes. Furthermore, I suggest a common mechanism of pathogenicity for many duplication events independent of the biochemical function of the encoded genes. With the availability of abundant high-quality genomics data, now is an opportune time to address these questions. Primarily through computational and statistical analysis I will reveal the relationship between gene duplication and expression and test a model that the indirect costs of gene expression are a major determinant of the outcome of gene duplication. I will explore the effects this has on gene and genome evolution. Finally, I will link the patterns of gene expression and duplicability to pathogenic effects.

Keywords: molecular evolution,gene duplication,evolution of gene expression,evolutionary rates
CO-FUNDED Brain Circulation Scheme 2 (CoCirculation2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Türkiye
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2018-07-02
End date: 2023-07-01
Duration (months): 60.0
Total project cost (EUR): 12390000.0
EU funding (EUR): 6195000.0
Participants: 1
Project status: SIGNED

CoCirculation2 is a 5-year project aiming to invite experienced researchers to both academic and non-academic research performing organizations located in Turkey. Within this context, 100 experienced researchers of any nationality who wish to engage in incoming mobility and to spend a period of 24 months in Turkey will be able to apply for a fellowship. 4 calls for proposals will be published. The program will have a bottom-up approach. The evaluation and selection procedures as well as recruitment procedures are in line with the conditions in the European Charter and Code. CoCirculation2 is the follow up project of the “Co-funded Brain Circulation Scheme (Co-Circulation)”, which has been funded under the FP7-PEOPLE-2011-COFUND call. Compared to the current Co-Circulation program, Co-Circulation2 will bring the evaluation and selection process closer to recommendations in the Charter and Code, allow for secondments, improve the training offer for fellows and improve the financial and social conditions of the fellowships. CoCirculation2 offers transnational mobility, career development and personal training opportunities to the researchers. In line with the European Commission objectives, the project will contribute to the potential and future career perspectives of researchers in academy and industry while enhancing their international networking and interdisciplinary skills. CoCirculation2 will create a new cohort of Experienced Researchers who have acquired relevant scientific and transferable skills during their research project and other activities during their fellowship. These skills will prepare them for the next steps in their professional career, either in academia or in non-academia, and either in Turkey or beyond. Turkish and European Research Area as a whole will benefit from the contribution of the CoCirculation2 fellows to the research landscape. TÜBİTAK will contribute 55% of the total budget while European Commission is requested to co-fund 45%.

Keywords: transnational mobility,integration to era,career development,refugee industry panel,incoming researchers training,bottom up approach,intersectoral secondment,scientific skill,brain circulation
Sustainable Reactor Engineering for Applications on the Water-Energy Nexus (REWATERGY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,Italy,Spain,Spain,Ireland,Cyprus,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-04-01
End date: 2023-09-30
Duration (months): 54.0
Total project cost (EUR): 2174048.28
EU funding (EUR): 2174048.2800000003
Participants: 14
Project status: SIGNED

The EU is currently facing the challenge of recycling materials and water of high quality to become carbon neutral by decreasing its energy consumption and CO2 emissions. The current Water Framework Directive has strict regulations on a wide range of contaminants, and most treatments continuously increase the energy demand of the water cycle. Yet, the EU is committed to ambitious targets to reduce Greenhouse Gas emissions, including the legally binding 2015 Paris agreement. These conflicting interests have motivated REWATERGY, a partnership within the water-energy nexus. This integrated network, led by industry in partnership with world leading academic institutions, envisions the scientific and technological opportunities of such challenges with direct economic and social impacts to the EU. Three research objectives set the foundation of this ambitious programme, i) enhance the energy recovery from waste water streams inspired by the circular economy concept, ii) improve the energy efficiency of water disinfection and removal of contaminants of emerging concern, and iii) increase the resilience of distributed household safe drinking water systems addressing potential health and safety challenges. The programme is particularly designed to cultivate an entrepreneurial spirit by the collaborative design, development and manufacturing of new prototypes aligned with the three research objectives. This training concept will have a long term impact by providing a stream of highly trained innovative scientists and engineers able to communicate ideas and to develop creative solutions for the adoption of novel technologies in the market.

Keywords: reactor engineering,energy efficiency,water treatment,catalysis,hydrogen,uv c,advanced oxidation processes,disinfection,antibiotics,enms,microplastics
Interactive web-based tool for the design of multi-RNA binding protein binding site cassettes (CARBP)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Israel
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-07-01
End date: 2020-06-30
Duration (months): 12.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

DNA synthesis technology has greatly developed over recent years, serving a growing multi-billion synthetic DNA market. Synthetic DNA is used in projects that optimize reagents, chemicals, crops and other organisms, in projects seeking to increase the manufacturing efficiency for the above, as well as in studies of molecular regulation and other cellular processes. The latter is the focus of the MRG-GRammar H2020 FET project. As the market and application range for synthetic DNA expand a need arises to test and quality control raw synthetic nucleic acids as well as products built upon such reagents. We have developed a prototype software tool for assessing quality parameters in synthetic DNA libraries and used it in several projects in the framework of MRG-GRammar We propose to productize this prototype into a stable version that will be availed to a broader synthetic biology community. Our proposed product, CARBP, is a software system that enables design of RNA binding protein binding sites cassettes for various applications in biological imaging and synthetic biology. Requested funding will be used to improve usability and user interface, to expand the implementation of analysis and statistical tools, to produce a stable version available to the scientific community and to commercial entities and, finally, to investigate potential sustainable mechanisms for supporting continued service, including commercial or service models. CARBP will form part of a suite of interactive web-based tools whose purpose will be to accelerate the development of the nascent synthetic biology industry sector, by making advanced molecular technologies available to various users at a push of a button.

Keywords: rna binding proteins,phage coat proteins,single molecule in single cell imaging
Compact all-fibre nonlinear resonators as technological platform for a new generation of miniaturised light sources. (PocketLight)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

The project aims for the implementation of a novel technological platform based on compact all-fibre resonators (CAFRs). I will exploit silica optical fibres treated via thermal poling to induce a second order nonlinear polarization. Periodically poled silica fibres (PPSFs), equipped with Bragg mirrors on both their facets, will be converted into quadratic nonlinear optical resonators with the target of exploiting the significant enlargement of the nonlinear interaction lengths. A complete study of the experimental conditions necessary to observe up and down conversion of light in the telecom wavelengths range inside those resonators will be realised. The main goal of the project consists in the implementation of an optical parametric oscillator (OPO) by exploiting the CAFR in doubly resonant configuration. This outcome would allow to open the way to a totally revolutionary type of all-fibre, integrated and compact laser/light sources based on nonlinear parametric processes. Another significant goal of the project is the first experimental observation of dissipative structures in these compact all-fibre resonators, with the main target of testing the theoretical predictions present in literature and shed new light onto some still unveiled aspects of dynamics of purely quadratic resonators.
Industrialization and commercialization of a competitive, sustainable and consumer oriented alternative animal protein source (Meat4All)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Spain,France,Portugal
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2020)
Start date: 2020-08-01
End date: 2023-01-31
Duration (months): 30.0
Total project cost (EUR): 2724231.25
EU funding (EUR): 1906961.0
Participants: 4
Project status: SIGNED

Meat4All's goal is to scale up cultured meat production technology, work on market acceptance and perform safety assessment tests to allow the industrialization and commercialization of poultry cultured meat. This project will allow to supply the ever-increasing global demand for animal protein while addressing the main drawbacks of factory farming industry: Health issues, environmental sustainability and animal welfare. By scaling up this technology Meat4All will create a new area of development that makes possible for the European industry to harness this market high potential, fostering competitiveness and creating growth throughout the EU. BF, with the collaboration of OT (peptone-based supplements) and NOB (SIGMA group; meat processors) proposes this project in order to take Cultured Meat production a step closer to the market. This project will allow BF to become a worldwide leader in Cultured Meat with the necessary production capacity to supply the meat processing industry, starting with NOB’s final innovative products. The project objectives are: • Scale up production process from 135 Kg scale to 10 Tons scale per year by 2021 • Maintain large nutritional value for large scale produced quantities • 100% animal free origin culture media • Maintain Health claims up to the final processed products • >80% bioreactor yields to keep prices within the acceptable level • 100% traceable Non-GMO animal cells • Meat4All will produce cultured meat in a raw format to be processed into consumer products as sausages or cold cuts. The average target selling price will be 6 €/kg in 2023 • Create markets leaders • Perform consumer product trials (tasting) aimed at ascertaining and predicting market and consumer demand.

Keywords: cultured meat,novel food,processed meat products,sustainable meat production
A holistic structural analysis method for cultural heritage structures conservation (HOLAHERIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-10
End date: 2025-01-09
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

HOLAHERIS proposes a holistic structural analysis method for cultural heritage structures (CHSs) conservation, introducing an original multidisciplinary framework that will make the safeguard and protection of CHSs less expensive, faster and more reliable than existing approaches. These features will allow to apply smart management to a wider range of CHSs. Scientific novelties will be introduced through 4 objectives: (1) innovative integration of 3D documentation data for rapid numerical model generation of CHSs, (2) innovative integration of structural health monitoring (SHM) and numerical modelling for decision-making in CHSs conservation, (3) sub-modelling-based stochastic dynamic analysis for seismic assessment of CHSs, (4) modelling environmental deterioration in historic building materials and composite strengthening systems. The HOLAHERIS activities will require a multidisciplinary approach, that will be achievable by merging the expertise of the 3 institutions involved: Princeton University (18-month outgoing phase, supervisor Prof Glisic and co-advisor Prof Finkelstein, experts in SHM and computer graphics), University of Minho (6-month secondment, supervisor Prof Lourenço, expert in historical structures), University of Bologna (12-month return phase, supervisor Prof de Miranda and co-advisor Dr Sassoni, experts in computational mechanics and materials science). Dr D’Altri will receive excellent training in the 3 institutions, expanding his knowledge. This new knowledge, combined with the publication of research results in top journals, will allow him to boost his career development and become a structural mechanics-expert tenured researcher in EU academia. The project will be organized in 8 work packages (WPs). The first 4 WPs will consider the 4 objectives, and WP5 will integrate them in a unique method to holistically treat the structural analysis of CHSs. WP6, WP7 and WP8 will deal with training, exploitation/dissemination, and project management.

Keywords: masonry,brickwork,brick,mortar,stone,buildings,monuments,structures,dynamics,earthquakes,degradation,damage,simulation,monitoring,modelling,analysis,documentation,conservation
Mineral Intelligence Capacity Analysis (MICA)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Coordination and support actions
Countries involved: Ireland,Albania,Germany,Germany,Spain,Italy,Austria,Austria,Spain,Cyprus,Belgium,Norway,Switzerland,Hungary,Finland,Greece,Croatia,Poland,Romania,Slovenia,Sweden,France,France,France,Netherlands,United Kingdom,United Kingdom,Portugal,Denmark
Call: Raw materials intelligence capacity (H2020-SC5-2015-one-stage, 2015)
Start date: 2015-12-01
End date: 2018-01-31
Duration (months): 26.0
Total project cost (EUR): 2005205.0
EU funding (EUR): 1998955.0
Participants: 34
Project status: CLOSED

Primary and secondary raw materials are fundamental to Europe’s economy and growth. They represent the most important link in the value chain of industrial goods production, which plays a prominent role as a source of prosperity in Europe. However, as stated in the call, there exists to-date no raw materials knowledge infrastructure at EU level. The Mineral Intelligence Capacity Analysis (MICA) project contributes to on-going efforts towards the establishment of such an infrastructure by projects such as ProMine, EURare, Minventory, EuroGeoSource, Minerals4EU, ProSum, I2Mine, INTRAW, MINATURA2020 and others. The main objectives of MICA are: - Identification and definition of stakeholder groups and their raw material intelligence (RMI) requirements, - Consolidation of relevant data on primary and secondary raw materials, - Determination of appropriate methods and tools to satisfy stakeholder RMI requirements, - Investigation of (RMI-) options for European mineral policy development, - Development of the EU-Raw Materials Intelligence Capacity Platform (EU-RMICP) integrating information on data and methods/tools with user interface capable of answering stakeholder questions, - Linking the derived intelligence to the European Union Raw Materials Knowledge Base developed by the Minerals4EU project. The MICA project brings together a multidisciplinary team of experts from natural and technical sciences, social sciences including political sciences, and information science and technology to ensure that raw material intelligence is collected, collated, stored and made accessible in the most useful way corresponding to stakeholder needs. Furthermore, the MICA project integrates a group of 15 European geological surveys that contribute to the work program as third parties. They have specific roles in the fulfilment of tasks and will provide feedback to the project from the diverse range of backgrounds that characterizes the European geoscience community.

Keywords: raw materials,stakeholder analysis,mineral policy,mineral intelligence