Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Macroscopic Quantum Superpositions of Light Generated by Quantum Cloning for Applications in Quantum Technologies (QCAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Quantum technologies offer new quality with respect to classical ones by enhancing sensitivity of measurements and offering unconditional security of information transfer. Their optical implementation within the current technology is limited by inefficient detection and use of single photons. The solution is to apply macroscopically populated quantum states of light (MQSL) created by quantum cloning. However, they suffer from low distinguishability. The aim of this project is to merge unique properties of these hybrid states with innovative filtering and detection methods for applications in quantum technologies. The new concept is to use a filter relying on a conditional weak measurement described by a positive operator valued measure. It preserves quantum coherences and entanglement. Also new detection techniques genuine to continuous variables will be tested. Existing sources of MQSL will be improved by quantum state engineering, broadening palette of the experimentally accessible non-Gaussian states. Genuine macroscopic entanglement and multi-mode Bell tests, possibly with preselection technique, will be demonstrated. Feasible entanglement witnesses and measures will be proposed. They will help testing MQSL for quantum information, cryptography, metrology, teleportation and entanglement distillation protocols. Coupling between MQSL and polaritonic Bose-Einstein condensate, also a macroscopic superposition of light, and biomolecules will be examined towards quantum memories. Decoherence effects will be included in all steps of the analysis. Additionally, conclusions about the fundamental aspects of quantum mechanics are expected: testing it against local hidden variable models and the quantum-to-classical transition. Methodology includes analytical and numerical computations within the framework of quantum optical methods and tools. This project supports the applicant in building her own group, completing habilitaion degree and home country career integration.

Keywords: p108 optics and quantum optics,macroscopic quantumm superpositions of light,quantum cloning,bell inequalities,quantum technologies,quantum information,quantum cryptography,quantum metrology
Modification of receptor tyrosine kinase signalling during tumour cell migration (MODSIGN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cancer is a major socio-economic problem in EU, with approximately 2.5 million cases diagnosed and 1.2 million deaths every year, and an annual estimated cost of 15 billion € for cancer therapy. Understanding the molecular mechanisms underlying cancer progression have revolutionized the field of targeted therapies, generating a growing number of inhibitors approved for use in the clinic. In particular, drugs targeting receptor tyrosine kinases (RTKs) have been successful. Although several of these therapies showed initial benefits, a recurring problem in cancer management is development of secondary mutations of the targeted proteins, causing drug resistance. To counteract this, there is an urgent need to identify the next generation of drug targets required to create the second line therapies that are critically needed. The specific aim of this proposal is to elucidate the molecular networks that modify RTK signalling output during tumour progression to metastatic disease, with the aim of identifying network nodes that can subsequently be targeted for drug development. The goal of this proposal is to investigate the molecular mechanisms whereby RTK signalling output is modified, and how they are altered during cancer progression to metastatic disease. In vivo, tumour cells are simultaneously exposed to signals initiated by a variety of oncogenes, cytokine receptors and adhesion molecules, and it is the integrated signals that determine the cellular phenotype. Realizing that cancer is a disease of networks, this proposal investigates signal integration at the level of regulating RTK internalization and trafficking. Specifically, the proposed research will significantly expand the understanding of the intersection between two interlinked networks that regulate RTK signalling, i.e. PTPs and endocytic trafficking. The ultimate aim of this line of research is to identify novel drug targets that can subsequently be exploited by the European pharmaceutical industry.

Keywords: l108 biochemistry of signal transduction,l302 cell biology and molecular transport mechanisms,l406 cancer and its biological basis,l308 signal transduction
Molecular mechanisms of microvascular dysfunction following hemorrhagic stroke (MICROFLOW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Stroke kills over 300,000 European citizens each year. Among the various forms of stroke subarachnoid hemorrhage (SAH) has the highest mortality, the worst prognosis, and the least well understood pathophysiology. Recent studies from the applicant's laboratory suggest that disturbances of the cerebral microcirculation may play an important role for brain damage after SAH. So far, however, little to nothing is known about the cellular or molecular mechanisms leading to microvascular dysfunction (mvD) following SAH resulting in an absolute lack of diagnostic and therapeutic options for affected patients. Therefore the aim of the current program is to investigate morphology and function of the cerebral microcirculation after SAH, to determine the molecular mechanisms responsible for mvD, and to use this knowledge to develop novel biomarkers and therapeutic options for SAH patients. For this purpose we will subject mice expressing fluorescent proteins in specific cells of the cerebral microcirculation (endothelium, pericytes, smooth muscle cells) to SAH and assess the temporal profile of morphology and function of these cells in vivo by 2-photon microscopy. To investigate gene expression associated with mvD we will employ microdissection microscopy for the isolation of microvessels from tissue sections and a novel strategy designed to capture mRNAs from specific cell types from whole brain tissue by using the Cre-lox system together with a transgenic mouse expressing an affinity-tagged ribosomal protein (Ribotag technology). Cell specific mRNA will then be analyzed by microarray technology. Finally, a small inhibitory RNA/lentiviral approach will be used to assess the therapeutic potential of identified disease-associated genes. The proposed research program may therefore result in the identification of novel biomarkers for the diagnosis of mvD in patients and in the development of novel strategies for the treatment of patients suffering from SAH.

Keywords: l511 neurological disorders,stroke,hemorrhagic stroke,subarachnoid hemorrhage,microcirculation,microvascular dysfunction,in vivo imaging,2-photon microscopy
Development of low-calorie beverages with prebiotic properties from cheap and abundant feedstocks (PROST!)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-07-01
End date: 2017-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

The demand for healthier and low-calorie foods is increasing worldwide. Galactooligosaccharides and fructooligosaccharides are considered to be naturally-occuring prebiotics because they can selectively stimulate the growth of beneficial bacteria in the colon, and thus, improve host health. These oligosaccharides (OS) also have excellent technological properties regarding to viscosity, stability, solubility, and taste. A common weakness of the current OS production technologies is the incomplete bioconversion that results in a carbohydrate mixture consisting of a considerable amount of residual disaccharides and monosaccharides. Further purification of this mixture involves complex, high-cost and low-yield technologies that restricts the application of OS in low-calorie food formulations. This 4-year research project is devoted to the development of a novel technology for manufacturing low-calorie, value-added beverages that have beneficial health effects. The proposed technology has two key steps. First, the sugars present in cheap and abundant feedstocks available within the EU, such as whey and molasses, are partially converted into valuable OS. Then, the obtained saccharide mixtures are further processed in a selective fermentation step using appropriate microorganisms that are capable of utilizing mono- and disaccharides but lack the power to hydrolyze OS to a higher extent. The utilized carbon source is not wasted but required for giving rise to odour and taste constituents. The resulting mildly sweet product has a prebiotic function due to the presence of remaining OS. This highly multi-disciplinary research gathers new experimental data, involves 'state of the art' experimental and theoretical analysis on fundamental phenomena and their implications to real-life systems, and attempts to identify process designs, that have promising potential for industrial implementation, taking into account technical, economical and environmental impact tradeoffs.

Keywords: g307 industrial bioengineering,l814 food sciences,l817 biotechnology (non-medical) - bioreactors - applied microbiology
Donor-Government Relations in Sub-Saharan Africa (PARTNERSHIP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2015-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The proposed CIG will advance a high-impact, socially-relevant research agenda on the political consequences of new forms of development assistance. The project is of particular relevance to the EU and its member states given that European development agencies are dramatically increasing allocations to new aid modalities, such as direct subsidies to recipient countries’ national budgets. For instance, the 10th European Development Fund (EDF) allocates €13.5 billion or 44% of its portfolio to budget support in ACP countries. The proposed research investigates why some bilateral and multilateral aid donors are increasingly willing to fund aid programs that give recipient governments a large amount of control over where and how aid money is spent. The shift towards these aid modalities is interesting given that governance and institutional capacity in recipient countries remains poor and there is little evidence that such approaches are more effective. The project will generate original empirical data and theory on how foreign aid influences domestic political processes in recipient countries and how the logic of bargaining between donors and recipient governments can explain a variety of observable outcomes in development policy. While it is well known that aid dependence alters recipient governments’ incentives for cooperation and good governance, the bargaining process between donors and recipient governments remains poorly understood. In addition to generating fundamental scientific knowledge about donor-government relations, the findings of this study will be directly applicable to the design and implementation of more effective development assistance. As the PI comes from the US academic context, CIG support for her integration into the European research community will dramatically enhance the academic and societal impact of her research. Key outputs include academic articles, policy briefs, and stakeholder conferences in Brussels and four African countries

Keywords: foreign aid,donor-government relations,aid effectiveness,state-society relations
Modelling Residential and Transport Energy for Downstream Policies (MODERATED POLICY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Energy consumption and thus carbon emissions in the domestic sector is responsible for more than 50% of UK carbon emissions (and between one-thirds to one-half in most EU countries) and presents a significant challenge to reducing GHG emissions from the EU. The overall goal of the proposed "ModeRATED Policy" project is to understand the impact and distributional burden of downstream policies, especially carbon trading at the personal or household level, in order to mitigate carbon emissions from the domestic sector (personal transport + in-home) of the economy, through developing an econometric demand model for joint consumption of in-house and transportation energy. The proposed project intends to make contributions to modelling in-house and transportation energy demand through developing an econometric demand model allowing for substitution between the energy consumptions in-house and for transportation needs of the households. Special focus will be on personal carbon trading as a policy to reduce emissions, and incorporation of an additional carbon budget in the theoretical microeconomic demand model. In addition, intermediate to long term trade-offs in energy saving/carbon saving behaviour will be investigated and incorporated in the model. Since there is no existing 'real' world example of carbon capped behaviour, the project will also seek to understand potential behavioural responses through potentially similar real world examples (e.g. vehicle lease for a given cap in km per month). Ultimately, the distribution of burden will be analysed for a carbon tax and a personal carbon trading policy. The results will significantly contribute to the current policy debate on the potential of downstream policies to help reduce carbon emissions from the households and thus reduce overall carbon emissions.

Keywords: energy demand model,personal carbon trading,joint model for residential and transport energy,econometric modelling,distributional burden,consumer demand theory,carbon budget,behaviour under cap
The Impact of Observational Learning on Brain and Behaviour Throughout the Lifespan (WATCH AND LEARN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-09-01
End date: 2016-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

As humans, our ability to survive within a social world is facilitated by learning through observing others. As such, when learning tasks as simple as tying one’s shoes or as complex as performing heart surgery, we learn by watching from childhood through to old age. Many researchers from the behavioural and brain sciences suggest that observational and physical learning share common features. What remains unknown is how our brains and behaviour change when learning by observation across the lifespan, as well as how age impacts the effectiveness of observational learning. To address these questions, I measure the impact of observational learning on behaviour and brain activity among children, young adults, and older adults. The ultimate aim is to develop a means of identifying factors associated with observational learning success, which in turn will inform observation-based interventions used in education and therapeutic contexts. The most direct implication of the ‘Watch and Learn’ project is a better understanding of how we transform visual information to physical skills from childhood through to advanced age. More broadly, those who teach or rehabilitate motor skills in people of all ages stand to benefit from the project’s findings through an improved understanding of how observational learning compares to physical learning in terms of behavioural performance, and how quickly or effectively individuals of different ages may be expected to learn by observation. Outreach activities are targeted at educators who teach physical skills in schools and hospitals, with the aim that observational approaches may be optimized based on the results of this project.

Keywords: l510 neuroimaging and computational neuroscience,s102 ageing - work - social policies,l507 cognition,s202 human life-span development,s213 education
Flexible Edge Nodes for Dynamic Optical Interconnection of Access and Core Networks (FENDOI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: TERMINATED

Research and standardization efforts during the past years have been intensified towards extending the scope of access networking to cover larger geographical areas and numbers of users. The main driver has been the reduction of CAPEX/OPEX costs by enabling consolidation of current Local Offices to a much reduced number of Central Offices. This paradigm blurs the hitherto defined boundaries between the access and the metro segments – the central offices become effectively Edge Nodes, required to handle significantly increased amount of user traffic. The goal of this project is to define novel, resilient, cost- and energy-efficient architectures achieving efficient access-core interconnection and convergence among heterogeneous access technologies, services and applications. At the end of this project, we would have proposed and validated concepts to achieve ultra high data rates (up to 100Gbps per wavelength), enhanced resource utilization and flexible bandwidth allocation at sub-wavelength granularities. The timely generated knowledge in this project will contribute to extend the-state-of-the-art and enhance European research excellence and competitiveness in developing future communication networks.

Keywords: g208 networks,g205 micro- and nanoelectronics - optoelectronics,g202 electrical and electronic engineering
Low Environmental Footprint Biological Treatment Processes for Waste and Wastewater Treatment (LEF-BIOWASTE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-12-01
End date: 2016-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

LEF-BIOWASTE focuses on the development, optimization and evaluation of innovative, low environmental footprint biological processes for the co-treatment of municipal wastewater and biodegradable organic waste (BOW). Waste and wastewater will be co-treated by an up-flow anaerobic sludge blanket (UASB) followed by a sequential batch reactor (SBR). Furthermore, an innovative autotrophic nitrogen removal (ANR) process of short-cut nitrification followed by ammonium oxidation by nitrite will be employed (i.e. Anammox process). Research shall focus on the effect of operating conditions on the system’s performance and particularly on the oxidation of ammonium to nitrite and the requirement for inhibition of nitrate formation as well as on the Anammox process. The Anammox bacteria are very sensitive and specific conditions are required for their growth in activated sludge processes. Furthermore, LEF-BIOWASTE will examine the fate and removal of targeted non-conventional and emerging pollutants. The work will be carried out by developing and operating a bench scale UASB-SBR-ANR and by operating an existing pilot scale UASB-SBR-ANR system. The environmental footprint of this system will be compared to conventional wastewater treatment processes by conducting a life cycle assessment. Furthermore, the system will be assessed using technical, environmental, economic and social criteria through a multi-criteria analysis tool.

Keywords: waste and wastewater treatment,anaerobic digestion,uasb,sbr,autotrophic nitrogen removal,micropollutants,anammox