Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable 4D hydrogels functionalised with plant-based nanoparticles for bone regeneration in cancer patients (GreenNanoBone)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: United Kingdom,Norway,Denmark,Finland,Poland,Ireland,Germany,Portugal,Moldova, Republic of,Spain,Luxembourg,Netherlands
Call: Advanced biomaterials for the Health Care (IA) (HORIZON-CL4-2024-RESILIENCE-01-TWO-STAGE, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 9080894.14
EU funding (EUR): 8649981.64
Participants: 18
Project status: SIGNED

PROBLEM: Medical-related-osteonecrosis of jaw (MRONJ) is a rare, but severe side effect of bone-targeting agents (BTAs), such as bisphosphonates. These agents are prescribed to survivors of breast cancer where they reduce the risk of secondary bone cancer. Unfortunately some people develop MRONJ, where progressive destruction of the jawbone leads to frequent infections, inability to eat and risk of malnutrition. MRONJ treatment focuses on controlling infection, pain and bone death through long courses of antimicrobial agents, contributing to development of antimicrobial resistance. Currently, ~12,000 people across Europe and the UK suffer from MRONJ. As people survive cancer longer, the number of cases is increasing. We urgently need a new prevention and treatment strategy for MRONJ. INNOVATION: GreenNanoBone will develop and validate sustainable, biocompatible, bioactive and antimicrobial 4D material to promote bone and tissue regeneration in a new strategy to prevent and treat MRONJ. The material will be injectable or printable as a scaffold for use in non-invasive surgical procedures. We will use AI to refine the properties of our plant-derived materials, test them using pre-clinical models, and ensure that they can be manufactured to medical standards. IMPACT: We address a clinical need and will reveal the pathophysiological mechanism of MRONJ in readiness for Phase I clinical trials (TLR-6) by the end of the project. In the longer term GreenNanoBone will dramatically increase quality of life for MRONJ patients and open up exciting possibilities for treating complex fractures and other skeletal conditions. We will develop a sustainable manufacturing process using recycling and clean raw material from a food (potato) waste side stream. The technology will enable production scale-up using climate-neutral methods. Our work will support European industries to undergo a Green Transformation and develop new markets, products, and services, boosting competitiveness.

Keywords: 4d green biomaterials circular economy cancer skeletal health minimally invasive surgery
Applied stereotypes, social networks, and self-fulfilling prophecies: how stereotypes reinforce social inequalities (STERN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1499253.75
EU funding (EUR): 1499253.75
Participants: 1
Project status: SIGNED

Social inequalities are reinforced within the education system. Stereotypes may have a major role in this, since they may lead to differential treatment of minority students, resulting in self-fulfilling prophecies that hinder their academic outcomes. Beyond the obvious role of teachers, that of peers is also crucial, as they are important parts of students’ socialisation: how they are perceived by peers could affect their motivation, interests, achievements, and relationships. However, it is not clear how much students apply stereotypes to their peers, given the wealth of individuating information they have about them. This project introduces the new concept of applied stereotypes: this expresses how an individual perceives another along stereotype-related dimensions, such as warmth and competence. I propose that applied stereotypes develop jointly with peer networks of school communities. For example, the application of stereotypes could be mitigated by friendships (judging one’s friends more positively) or by accepting the established personal reputation of specific peers as warm or competent instead of judging them based on stereotypes. Such peer-based processes of stereotype application, combined with the effect of applied stereotypes on outcomes, are crucial to understand, as students’ educational trajectories emerge gradually in school, surrounded by peers. The project investigates social mechanisms that explain the dynamic interplay between stereotypes, applied stereotypes, and outcomes. As there is no established way to measure applied stereotypes, I develop a novel dyadic measure that captures who perceives whom in what way and collect detailed data in ten English secondary schools. I conduct empirical analyses by using and extending cutting-edge methods of social network analysis. By taking a so-far neglected level of applied stereotypes into account, this project has the potential for a ground-breaking impact on the study of social inequalities.

Keywords: stereotypes,social networks,education
Deciphering the interplay between stem cell differentiation and stem cell dynamics in branching morphogenesis (Stem2MorphoMap)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

Tissue development requires the orchestration of stem cell differentiation and morphogenesis, a process that is conspicuously observed in mammary gland (MG) branching. The MG develops from an embryonic bud of mammary stem cells (MaSCs). Although these stem cells are initially bipotent, giving rise to the outer (basal) and inner (luminal) layers of the adult gland, they become lineage restricted very early in embryogenesis, at around the time of the onset of branching morphogenesis. The timing of lineage restriction coincides with the differential expression of cell polarity and cell adhesion transcripts. Branching morphogenesis then relies on differential cell division, as well as cell rearrangements and migration, but the mechanisms regulating this process in the embryo remain poorly understood. Based on these observations, we postulate that basal-biased and luminal-biased MaSCs have distinct molecular features during branching morphogenesis. We therefore propose to functionally link the signaling pathways involved in restriction of stem cell potency to the cellular dynamics that ensure branching. To this end, we will characterize the dynamic behaviour of individually labeled MaSCs during the growth of embryonic MG explants and assess their fate, creating a complete fate-behavior map of MG development. Through genetic manipulation, we will probe how cell adhesion, migration, and division impact on lineage specification and tissue growth. Simultaneously, we will skew stem cell differentiation trajectories and assess their influence on cell behavior and organ shape. The outcomes of this project will provide novel insights into the coordinated developmental programs governing stem cell fate and morphogenetic events, both essential to tissue formation. Moreover, they might uncover potential connections to cancer, where differentiatiom and cell polarity play pivotal roles.

Keywords: branching morphogenesis,stem cell plasticity
Underwater Security (UnderSec)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Border Management
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Bulgaria,Greece,Croatia,Cyprus,Spain,Italy,Luxembourg,Portugal,Romania
Call: Improved underwater detection and control capabilities to protect maritime areas and sea harbours (HORIZON-CL3-2022-BM-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 5986393.75
EU funding (EUR): 5984893.75
Participants: 22
Project status: SIGNED

Maritime security, including the underwater, is of paramount importance to assure the smooth and safe transportation of goods and people to/from the EU ports, as well as to preserve uninterrupted operations of critical coastal-based/river-based/maritime infrastructures. Ships and maritime infrastructures need to be protected against all illegal acts through a) continuous 24/7 underwater security surveillance against potential intruders divers, hostile underwater vehicles and illicit/dangerous containers towed by ships, b) on-demand ships’ hulls scanning/inspection for the best possible detection/recognition/classification of strapped, attached, hidden or misplaced illicit (i.e. narcotics) and dangerous material, c) underwater inspections of ports’ entrances, seabed and docking places foundation for the best possible detection/recognition/classification of dangerous containers (i.e. CBRNE packages and IEDs) at these places, as well as to apply deterrent and response measures, in order to prevent/deter illicit acts and avoid undesired escalation of security incidents. To that end, the multinational and interdisciplinary UnderSec project team, consisting of experts in the maritime security and underwater security domain, research/academic institutions and technology, and End-Users from the Coast Guard, Borders Control, and Port Authorities sectors, will develop a modular/holistic approach Prototype System, consisting of multimodal sensors and robotic assets, for ships’, ports’ and maritime infrastructures’ Underwater Security Situational Awareness and Decision-Making Support, with relevant Response capabilities. Individual technologies will be tested, compared with each other and pre-evaluated in a controlled environment, while the modular components and the system as a whole will be tested and evaluated during real-life PUCs demonstrations in actual operational environments, resulting in the establishment of new knowledge, innovative solutions and advanced processes.

Keywords: underwater threats detection,underwater threats classification,underwater security risk assessment,situational awareness,decision making support
FERBOPO – FOSTERING EXCELLENCE IN RESEARCH ON STATE-CHURCH-BODY POLITICS (FERBOPO)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Romania
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The FERBOPO proposal aims at building a new research group at Lucian Blaga University of Sibiu (LBUS) focused on the complex relationship between State, Church and Body Politics that would foster excellence in social sciences and better integrate LBUS in the European Research Area (ERA). To this end, LBUS will create a CHAIR position for Professor Lavinia STAN from St. Francis Xavier University (Canada), whose outstanding academic profile and thorough expertise in the cross-cutting fields of government, religion, economics and epistemology that foster (de)colonial feminist thinking (Lugones, 2010; Manning, 2021) and the institutionalisation of Gender Studies in Romania (Turcescu and Stan, 2005; Stan, 2010) will help increase the number of excellent research staff and improve their capability to attract competitive research funding with significant spill-over effects at societal level, while also assisting LBUS to implement institutional reforms that both align with ERA priorities and facilitate the implementation of the Gender Equality Plan (GEP). The main objective of this FERBOPO is to create a ‘pocket of excellence’ in LBUS by attracting outstanding scientists with internationally mobile academic careers so as to improve the host institution’s organizational culture and the academic outputs of LBUS scholars. Romanian higher education institutions continue to lag behind their Western counterparts in their governance effectiveness and academic performance indicators (Dobbins, 2017). An acute scientific production deficit is related to Gender Studies (Vlase and Terian, 2023). By creating the new chair and research group, the proposed ERA Chair will help LBUS to near European standards of academic performance and institutionalisation of Gender Studies. Through the employment at LBUS of the ERA Chair holder, FERBOPO will contribute to the creation of a knowledge hub in the university, in particular, and the Romanian higher education system, in general.

Keywords: gender,body politics,church,state,gender equality plan
Towards GEMINI: A Generation of Multi-scale Digital Twins of Ischaemic and Haemorrhagic Stroke Patients (GEMINI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Netherlands,Italy,Ireland,Poland,Germany,France,Switzerland,Spain,Hungary,Taiwan, Province of China,United Kingdom,South Africa
Call: Integrated, multi-scale computational models of patient patho-physiology (‘virtual twins’) for personalised disease management (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2023-12-01
End date: 2029-11-30
Duration (months): 72.0
Total project cost (EUR): 9991877.5
EU funding (EUR): 9991877.5
Participants: 23
Project status: SIGNED

GEMINI aims to deliver validated multi-organ and multi-scale computational models for treatment decision support and improved fundamental understanding of acute strokes, both ischaemic and haemorrhagic. We will demonstrate the added benefit of these computational models in personalised disease management. Specifically, GEMINI will deliver validated, integrated multi-scale, multi-organ Digital Twin in Healthcare (DTH) models for cerebral blood and cerebrospinal fluid flow, brain perfusion and metabolism, and blood flow and thrombosis along the heart-brain axis by integrating available and newly developed dynamic, interoperable, and modular computational models. Building on these models, GEMINI will deliver validated population-based DTHs of ischemic and haemorrhagic stroke aetiology and onset, treatment, and disease progression. Utilising these population-based DTHs, GEMINI will validate five personalised subject-specific DTHs, (1) stroke treatment, and (2) disease progression DTHs for acute ischaemic stroke and (3) aneurysm treatment, (4) subarachnoid haemorrhage progression, and (5) unruptured intracranial aneurysm risk assessment DTHs for haemorrhagic stroke to guide patient care and long-term management. We will bring proof of value of digital twins by the evaluation of the ischaemic stroke treatment selection DTH in a multi-centre clinical trial, in which treatment and patient outcomes are compared in situations with and without the availability of a DTH. GEMINI will implement a project-wide structured approach for data harmonisation, curation, model validation, verification, and model certification of the DTHs. Several outcomes of GEMINI have a high value for clinical practice, medical device industry, and in enhancing research in the fields of (bio)medical and computer sciences, warranting an extensive valorisation strategy with adequate IP protection and versatile exploitation actions to enhance a wide adaptation of the results of GEMINI.

Keywords: digital human twin in healthcare,ischaemic stroke,haemorrhagic stroke,treatment,aetiology,disease progression,validation,verification,treatment selection support
Unveiling organomineral associations at the nanoscale by bridging their structure and dynamics (NANOCLICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2499875.0
EU funding (EUR): 2499875.0
Participants: 1
Project status: SIGNED

The NANOCLICS project will demonstrate that metallic polymers of just a few atoms linked to organic molecules are the pivotal organomineral association structures in soils. They form an hydrated gel nanostructure called nanoCLICs. The project will: 1) explore their structure at the nanoscale in 10 soil types; 2) elucidate the nanoCLICs dynamics; and 3) quantify their contribution to soil carbon sequestration. The project will rely on the nanoCLICs molecular model that I previously developed. Organomineral associations stabilize organic compounds in soils, which is crucial for long-term carbon sequestration and plant nutrition. Demonstrating that metallic polymers of a few atoms linked to organic molecules are the molecular units of these associations is key to understanding carbon stabilization, but their nanostructure and dynamics must first be deciphered. Organic molecule adsorption on mineral surfaces is often put forward to explain the persistence of organic compounds in soils. However, direct in situ characterization in intact samples has been challenging due to the lack of true nanometer-scale resolution analyses. My recent studies have demonstrated that organomineral nanostructures can now be characterized using advanced nanometer-resolved nanoscience techniques. By using these techniques, which I recently applied to Andosols, we will fulfil three objectives: STRUCTURE: we will explore the nanoCLIs structure at the nanoscale in 10 soil types using nanoscale spatially resolved imaging techniques DYNAMICS: we will elucidate the nanoCLICs dynamics (formation, evolution, disruption) using a specifically developed long-term column experiment MODEL: we will quantify nanoCLICs contributions to soil carbon sequestration by linking nanoscale organomineral knowledge with operational carbon storage models The NANOCLICS project will unlock crucial insights into the stabilization and destabilization of soil organic matter, enhancing soil carbon management.

Keywords: soil organomineral associations,carbone storage,nanoscale,soil carbon dynamics
DVD-readable opto-electrochemical Lab-on-a-Disc as small-factor wearable wireless medical device for obesity management (DVD-E)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-07-31
Duration (months): 30.0
Total project cost (EUR): 278409.6
EU funding (EUR): 278409.6
Participants: 5
Project status: SIGNED

Obesity is one of the most common and costly chronic disorder worldwide, and is a causal or a strong risk factor for several comorbidities, as type 2 diabetes (T2D), which is now reaching epidemic proportions. To monitor multifactorial disorders such as obesity and T2D, clinical evidences from more than one energetic biomarker are crucial. Current multiplexed systems present limited multiplicity capacities because they combine individual tests spatially separated from the others requiring complex and bulky instruments (e.g. HPLC), so they are difficult to operate out of the laboratory. Other described tests also cannot be adapted to monitor chronic disorders because they present at least one of the following critical limitations: (1) they are semi-quantitative (e.g. lateral flow test) so cannot perform the analyte monitoring to the required level of precision, (2) restricted to a single analyte which does not address the accepted criteria that an obesity management requires clinical evidence from multiple biomarkers and/or (3) cannot integrate the microfluidic processing required for blood analysis. To overcome current limitations, a novel multiplexed medical device is proposed here to enable for the very first time the fully control and management of chronic disorders as obesity and T2D. This will combine optics, electrochemistry, microfluidics and optoelectronics to monitor the most appropriate energy biomarkers (succinate as novel metabolite, in addition to lactate, ketones, pyruvate and glycaemia) in a friendly and decentralised way. No one has previously proposed a useful multiplexed approach as this, allowing the opportunity of the control of a particular energy biomarker such as succinate, which will facilitate current chronic disorders management. Thus, this novel cost-effective and portable multiplexed medical device, with unique and unprecedented attributes, will play a role key in the accurate management of chronic disorders.

Keywords: lab on a disc load point of care poc obesity and associated complications management dvd readable optoelectrochemical load multiplex analysis of glucose,lactate,succinate and acetate