Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
In Meso Crystallogenesis of GPCR-protein ligand complexes. (ADUKKIPA74)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-08-01
End date: 2012-07-31
Duration (months): 24.0
Total project cost (EUR): 238782.8
EU funding (EUR): 238782.8
Participants: 1
Project status: CLOSED

G protein-coupled receptor (GPCR) proteins are the single largest drug target, representing 30% of all marketed drugs. All GPCRs share a basic structural core of seven transmembrane alpha-helical domains. In spite of this similarity, GPCRs have evolved to be extremely versatile receptors for extracellular messengers as diverse as biogenic amines, purines and nucleic acid derivatives, lipids, peptides and proteins, odorants, pheromones, tastants, ions like calcium and protons, and even photons. Due to their significant effect on human physiology and disease, it is crucial to understand from a structural biology perspective, the molecular basis for the interaction between a GPCR and its ligand. The recent success in the structure determination of the Beta2-adrenergic GPCR and the adenosine A2a GPCR using the in meso crystallization methodolgy paves the way for further advances in structure determination of GPCR structures. As of today, there is no structural information available that helps us in understanding the molecular basis of interaction between a GPCR and its protein ligand. In this application, we propose to perform structure-function studies on two GPCRs, CXCR4 and Formyl Peptide Receptor, that are activated by the polypeptides SDF1 and f-MLF respectively. We propose to use in a synergistic fashion two novel methodologies, the BACMAM system and in meso crystallography, to express, purify and crystallize complexes between CXCR4-SDF1 and FPR-fMLF. Information obtained from the structure determination of these complexes would go a long way in helping us understand the molecular mechanisms responsible for the signal transduction properties of GPCRs that are activated by protein ligands. In addition, this information would also help us in designing and developing better drugs aimed at treating cancer metastases, AIDS and Parkinsons disease.

Keywords: gpcr,bacmam,in meso crystallography,cancer,health sciences
INTEGRATION OF INTERNATIONAL MARRIAGES: EMPIRICAL EVIDENCE FROM EUROPE AND NORTH AMERICA (INTERMAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-01-01
End date: 2013-12-31
Duration (months): 36.0
Total project cost (EUR): 235778.9
EU funding (EUR): 235778.9
Participants: 1
Project status: CLOSED

Increased international migration had brought the integration of immigrants to the forefront of sociopolitical topics. Although the economic and political aspects of immigrant integration have been scrutinized, little is known about immigrants’ social interactions with the native population. Interethnic marriages have been posited as a factor that undermines racial barriers and, thus, contribute to the integration between immigrants and natives. The scant studies of divorced couples comprised of immigrants and natives found that mixed couples are more likely to divorce that homogeneous couples and explained this gap by individual and mainly cultural factors. Nevertheless, these studies were conducted in single countries and thus, they did not investigate the effect of environmental factors such as national integration models and immigration policies. This study aims to fill this gap in the literature by analyzing factors affecting the survival of international marriages (i.e., couples in which the spouses come from different countries) in Europe and North America. I will employ the concept of the ‘liability of foreignness’ to build a model in which micro (individual), meso (cultural) and macro (immigration policies) level factors interact to predict the differential rates of international marriage survival across immigrant groups and host countries of the Old and New Worlds. A set of empirical studies will be conducted in selected European and North American countries - such as Spain, Greece, Germany, Sweeden, Switzerland, Denmark, Norway, Canada and the United States - to test this model. The comparison between European and North American countries will allow me to analyze the potential effect of different immigration histories and policies on the integration between newcomers and local people. The selection of countries depends on data availability and differences in immigration policies and integration models in the Old and the New Worlds.

Keywords: international migration,integration,marriage,divorce,europe,north america
The Model Theory of Groups (MODGROUP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 173903.2
EU funding (EUR): 173903.2
Participants: 1
Project status: CLOSED

The topic of the project is to develop new connections between model theory (a subfield of mathematical logic) and algebra, involving applications to group theory. We propose to work on some questions regarding groups definable in various important first order structures: o-minimal, without the independence property (NIP) and algebraically closed valued fields (ACVF) and others. Especially, we are interested in model-theoretic connected components of such groups. The quotient of the group by one of its model-theoretic components connected with `logic topology' is a quasi-compact topological group, and can be seen as a canonical set-theoretical invariant of first order theory of a given group. We plan to investigate in this context groups of Lie type (e.g. Chevalley groups), finitely generated nilpotent groups and algebraic groups over valued fields. We aim also to initiate a systematic study of the model theory of affine buildings, and of associated groups of automorphisms. We intend to combine classical Lie theory, results about covering numbers of Chevalley groups and some applicant's achievements. Working on affine buildings we use the classification of Bruhat-Tits buildings. The solutions to our conjectures and questions give us a results of new kind not only in model theory but in algebraic group theory and in additive combinatorics.

Keywords: group theory,mathematical logic,model theory,geometry
Spin transport and dynamics in silicon-germanium islands (SDYSIGIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-04-02
End date: 2012-04-01
Duration (months): 24.0
Total project cost (EUR): 165145.6
EU funding (EUR): 165145.6
Participants: 1
Project status: CLOSED

This project is centered on spin-dependent electronic transport and spin dynamics in self-assembled SiGe islands, directed at the development of semiconductor spintronic devices. In spite of its promising properties, SiGe remains a largely unexplored system for this purpose. The proposed project is further motivated and supported by an existing experience in the host group, which has recently succeeded in the realization of the first electronic devices based on individual SiGe quantum dots (QDs). Experimental effort will be first focused on the implementation of ferromagnetic (FM) contacts to the SiGe islands. Subsequently, low-temperature tunnel magnetoresistance (TMR) measurements will be performed as a function of the gate voltage and tunnel-coupling. The TMR response will provide important information concerning spin-injection efficiency and the impact of the Coulomb blockade phenomenon. Moreover, the effect of electric fields on the TMR response will be investigated, in order to identify signatures of Rashba spin-orbit interaction. To this end, dual-gate devices will be fabricated and their operation studied down to temperatures as low as 15 mK. Finally, the spin blockade regime will be exploited in order to explore the dynamics of single hole spins in SiGe islands. In particular, we aim to obtain important information on the characteristic time scales for spin relaxation and to perform coherent spin rotations by means of ac electric fields (via Rashba spin-orbit coupling). The proposed research project is also expected to create interesting opportunities for fundamental studies of exotic spin-related effects, resulting from the competition of ferromagnetic correlations, superconductivity, and Kondo effect.

Keywords: solid state physics,physics of semiconductors,electronic,magnetic and superconductive properties,electron-based nano-devices,spintronics,electron spin resonance
Role of prolyl oligopeptidase in neuroinflammation and novel therapeutic use of specific POP inhibitors (POP IN INFLAMMATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 178088.0
EU funding (EUR): 178088.0
Participants: 1
Project status: CLOSED

Neurodegenerative diseases present a broad range of phenotypic symptoms derived from deterioration of different brain functions, such as controlling movements, processing information or memory. All those symptoms are caused by the loss of specific neurons controlling those processes. All neurodegenerative diseases result from damage of neurons or their myelin sheaths that eventually will lead to dysfunction and disabilities. The neuroinflammatory hypothesis of neurodegenerative diseases proposes that inflammation contributes to their pathogenesis. Recent studies have provided information of the direct role of prolyl oligopeptidse (POP) and its specific inhibitors in toxic neuroinflammatory responses, since has been observed that POP is 1) mediator of human microglial neurotoxicity, 2) it is involved in the production of chemoattractants and proinflammatory chemokines derived from collagen and 3) in vitro POP substrates ameliorates behavioural deficits in Alzheimer’s disease models by reducing neuroinflammatory responses. The project aims to contribute to the knowledge on the molecular mechanism involving POP and its inhibitors in the frame of inflammation and neurodegeneration, with the last objective of promoting therapeutic applicability of POP inhibitors. The proposal implementation will consider different approaches, such as clinical and biochemical and pharmacological studies in cell cultures and animal models. During the carry out of the project, we will measure POP activity and protein levels from patients suffering neurodegenerative diseases as well as we will evaluate the endogenous POP inhibitor. In addition, we will test the impact of POP inhibitors on induced neurotoxicity cell cultures and on the pathology progression of animal models. The proposal promises to generate applicable research, strengthen collaborative agreements and promote the convergence of efforts to increase the European competitiveness.

Keywords: health sciences,neurosciences,pharmacological sciences,neurochemistry
Microbial and Geochemical Factors influencing the speciation of uranium in the subsurface (MONO-U4)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-06-01
End date: 2012-05-31
Duration (months): 24.0
Total project cost (EUR): 174065.2
EU funding (EUR): 174065.2
Participants: 1
Project status: CLOSED

The remediation of uranium-contaminated sediments and aquifers remains a major environmental challenge, yet the processes that control uranium speciation and mobility in the subsurface remain largely unknown. In anoxic systems, two major processes may lead to uranium reduction: direct electron transfer via bacterial metabolism or indirect electron transfer from microbially- reduced metals. Our initial experiments confirm that bacterial reduction of U(VI) may lead to the stable mineral uraninite (UO2), but in some cases a non-uraninite U(IV) species is produced. This species has been dubbed ‘monomeric U(IV)’ due to the absence of a feature in the x-ray absorption spectrum that is characteristic of the U-U interaction found in uraninite. The presence of this monomeric U(IV) species is an important development because is expected to be less stable than uraninite. Thus, its formation may have critical implications for predicting uranium immobilization in the subsurface. Here we propose an interdisciplinary project, utilizing tools from microbiology, geochemistry, and spectroscopy, to determine the conditions that mediate the formation of non-uraninite U(IV). We will initially conduct batch experiments with several bacterial species, both in the presence and absence of iron as an electron acceptor, and monitor the production of iron and uranium precipitates. Using a suite of tools including transmission electron microscopy, selected area electron diffraction, Mössbauer spectroscopy, and extended x-ray absorbance fine structure, we will identify the speciation of reduced uranium and the mechanisms that control its reduction. Based on these results, we will conduct a series of uranium flow-through column studies to more closely simulate natural conditions. The results of these studies will help in planning environmental remediation strategies at uranium-contaminated locations and in nuclear repository design.

Keywords: uranium,iron,vivianite,bioremediation,geobacter,shewanella,uraninite,geologic nuclear repository
Alsted in Transylvania, 1629-1638: the missing link in a major European intellectual lineage (SEDULITAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2011-08-31
Duration (months): 12.0
Total project cost (EUR): 84020.4
EU funding (EUR): 84020.4
Participants: 1
Project status: CLOSED

The profound influence on the young Leibniz exercised by J. H. Bisterfeld has been known for a century; yet only very recently has scholarship begun to appreciate its significance. During the past decade, a series of monographs by H. Hotson have identified Bisterfeld’s father-in-law—Alsted, the teacher of the renowned Comenius—as a central figure, the culmination of the greatest encyclopaedic tradition of his age. More recently still, M. R. Antognazza’s pioneering biography of Leibniz has situated the encyclopaedic project inherited from Bisterfeld and Alsted as the centre-piece of Leibniz’s enormously variegated life’s work. This new scholarship thus raises for the first time the possibility of rooting one of central Europe’s greatest thinkers within a highly distinctive but previously neglected central European intellectual tradition. Yet one crucial link is still missing from this genealogy: a detailed study on Alsted’s final decade in Transylvania. My sustained researches have unearthed a rich body of entirely fresh documentation which reveals beyond doubt Alsted’s vital role in preparing the brilliant works published by Bisterfeld which so fired the philosophical imagination of the young Leibniz. Many of these findings have already been sketched out in Hungarian; but to bring them fully into contact with international scholarship they now need to be reworked in English in the midst of the scholarly community most responsible for driving forward research in this field and deeply committed to mentoring younger scholars. The group working in Oxford on 17th-century intellectual networks provides the ideal context for bringing my long-standing research to its richest possible conclusion. Situating Transylvania at the centre of this important new intellectual lineage, in turn, will demonstrate how an expanded EU can enrich Western scholarship and transform key elements of our common intellectual heritage while laying a firm basis for my research career in Hungary.

Keywords: intellectual history,early modern philosophy,encyclopaedism,leibniz,alsted,bisterfeld,comenius,ramism,lullism,art of memory,art of combination,history of knowledge,history of the book
Spatial organization and dynamics of Escherichia coli RNA degradation machinery. (RNASEDYNAMICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 149783.6
EU funding (EUR): 149783.6
Participants: 1
Project status: CLOSED

The aim of this research proposal is to investigate in detail the location and mobility of RNA degradation machinery in E. coli. RNA decay has been widely studied in bacteria but continues to reveal subtle secrets [1,2]. Recent research demonstrates that the degradosome complex forms cytoskeletal-like structures linked with the inner cell membrane [3]. Preliminary results from Cecilia Arraiano’s laboratory (host laboratory) have shown that RNase R colocalises with the bacterial nucleoid, whereas RNase II is exclusively a cytoplasmic protein. Consequently, the main bacterial nucleases may have different cellular locations. After developing a system for in vivo localisation of RNases I will investigate their dynamics, likely factors that influence their mobility, and consequences of differential location. Because environmental stresses alter levels of RNases, I will check whether rearrangement of the degradation machinery is connected to changes in its cell location, and/or is linked to the formation of degradation foci analogous to eukaryotic processing/degradation P-bodies. This year it was reported in Science that abortive E. coli polymerase transcripts are produced in vivo during transcription initiation [4]. I will therefore investigate whether RNase R location in the nucleoid is functionally connected to degradation of these newly discovered small RNAs.

Keywords: molecular biology,microbiology,rnase,rna degradation,localisation,bacteria,abortive transcription
Molecular basis of cell communication during a migratory event that establishes brain asymmetry in zebrafish (CCMEBAZ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-03-01
End date: 2013-02-28
Duration (months): 24.0
Total project cost (EUR): 181103.2
EU funding (EUR): 181103.2
Participants: 1
Project status: CLOSED

The long-term aim of the proposed study is to resolve the genetic and cell biological mechanisms that contribute to the establishment of vertebrate brain asymmetry. In the zebrafish forebrain, an event crucial in establishing and elaborating asymmetry is the migration of the parapineal primordium. Parapineal cells are specified bilaterally at the midline. They subsequently assemble into a rosette-like structure and migrate to the left side of the brain. The molecular basis of the cellular communication among the parapineal cells during migration is still poorly understood. Preliminary data in Dr Wilson’s group show that Fgf8 induces highly focal pathway activation prior to and during migration. Fgf-reporter activation is found only in one or a few cells that are likely at the leading edge of the migrating primordium. This reporter activation occurs concurrently with suppression of activity in adjacent cells. Our hypothesis is that Fgf pathway activation non-autonomously suppresses pathway activity in neighbouring cells thereby establishing polarity within the entire primordium. In the proposed project, I will utilise multiple techniques to address specific questions with the following immediate aims: 1) to establish how localised activation of Fgf signalling correlates with parapineal migration; 2) to determine how Fgf pathway activation non-autonomously regulates pathway activity in neighbouring cells by addressing the roles of candidate interacting pathways (Notch and Wnt); 3) to determine the molecular mechanisms that govern the cross-talk between Fgf signalling and any of the identified candidates in aim 2.

Keywords: health sciences,neurobiology,biological sciences,cell biology,developmental biology,molecular genetics
Brain Diagnostics and Monitoring in early neonatal period (BraDiMo) (BRADIMO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-05-01
End date: 2014-09-01
Duration (months): 36.0
Total project cost (EUR): 266265.2
EU funding (EUR): 266265.2
Participants: 1
Project status: CLOSED

EU level payload from medical conditions associated with acute threat to brain in neonates (such as preterm birth or birthasphyxia) rises upto billions of euros each year. Yet the means to protect or monitor brains in neonatal intensive care units are far from optimal, and every improvement to this practice is likely to yield very high returns. The aim of this proposal is to fund development of research activity of Dr. Sampsa Vanhatalo (Helsinki University Hospital, Finland) who seeks to visit for two years the largest neonatal research center in Australia, led by prof. Paul Colditz (University of Queensland, Brisbane, Australia). Vanhatalo has gained outstanding international reputation from the pioneering developments and findings in the field of neonatal neurophysiology. He is now aiming at proceeding in this career and establish a frontier level neonatal research center in Helsinki. The research center of prof Colditz offers an ideal combination of skills and expertise that Vanhatalo will need in his research and career development in Finland/EU. Colditz laboratory uses several novel resarch paradigms (such as magnetic resonance imaging of preterm babies, translational experimental models, and modern signal analysis paradigms). They also have extensive experience in international management of research projects and funding, an exceptionally wide experience in commercialization of science, as well as highly recognized success in building media relations, which have become crucial in conducting successful clinical research. Training in all these areas is readily available in the Australian host institute. The fellowship will be utmostly important for Vanhatalo’s prospective academic activity, which is determined to develop the excellence in neonatal neurophysiology research in Finland and Europe, as well as to promote European medical industry to build applications for worldwide markets in the field.

Keywords: health sciences,pediatrics,brain research,neurophysiology,neonatology,brain monitoring