Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Approximation Methods for Molecular Modelling and Diagnosis Tools (AMMODIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Ukraine,Italy,Austria,Germany
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-08-01
End date: 2019-07-31
Duration (months): 48.0
Total project cost (EUR): 823500.0
EU funding (EUR): 823500.0
Participants: 6
Project status: CLOSED

This proposal brings together research teams from the EU (Germany, Italy, and Austria) and the Ukraine (Kyiv, Donezk) in the area of applied mathematics with emphasis on medical and life science applications. The goal is joint research in six research tasks concerning the study of mathematical methods for Magnetic Particle Imaging; entropy-like measures and quantification of system complexity; coarse-grain modelling for (bio)polymers; diagnostic tools for cardiac surgery; regularization methods for causality detection; meta-learning approach to Nocturnal Hypoglycemia prediction. Each such task will incorporate 24 months of research secondments (18 to the EU, 6 to UA). Four project events (one per year), each including a scientific workshop, a training school and public outreach activities, are planned to be held in the Ukraine involving a total of 27 secondment months. Senior scientists from Ukraine will have 15 secondment months targeted – apart from scientific and management work - at discussing issues how their institutions should develop in a restructuring of the Ukrainian research landscape.

Keywords: computational mathematics,life sciences,magnetic particle imaging,quantification of complexity,coarse grain modelling of polymers,mass spring approach,regularization method,meta learning
A New Spin on Quantum Atom-Light Interactions (NEWSPIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1921067.0
EU funding (EUR): 1921067.0
Participants: 1
Project status: SIGNED

A central goal of quantum optics is to realize efficient, controlled quantum interfaces between atoms and photons. Such interfaces enable broad applications from quantum information processing to quantum nonlinear optics to metrology, and also open a route toward creating exotic quantum states of light and matter. Today, our major paradigm for realizing an efficient interface is based upon the concept of collective enhancement, where using a large number of atoms creates an enhanced coupling to a preferred optical mode over undesired emission into other directions. However, our known error bounds for applications decrease very slowly as a function of system resources, such as the optical depth, thus posing a great challenge for future technologies. In NEWSPIN, we propose a remarkable new way forward, based upon the realization that these conventional error bounds are derived without accounting for multiple scattering and wave interference between emitting atoms. We aim to establish that interference in light emission is in fact a much more powerful resource than the level that we currently exploit it. In particular, beyond the usual collective enhancement, it can simultaneously enable a much stronger collective suppression of emission into undesired directions, and which can yield exponentially better error bounds than was previously known. Underlying this powerful paradigm shift will be the development of a quantum many-body theory of multiple scattering involving photons and atoms, which takes advantage of state-of-the-art tools from condensed matter physics. Beyond robust new routes toward applications, our theory will also reveal exotic new quantum phenomena and lead to new insights into fundamental questions in optics, such as the physical limits to how large the refractive index of an optical material can be. In total, we anticipate that NEWSPIN could greatly enrich our understanding of atom-light interactions and their realm of possibilities.

Keywords: quantum optics,atom light interactions,atomic ensemble
Controls on knickpoint migration and consequences for landscape evolution: experimental and numerical modelling (WaterfallModel3D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

As the link between the fluvial network and hillslopes, bedrock channels mediate the response of the landscape to changing boundary conditions, such as tectonics and climate through migrating ‘knickzones’ or ‘knickpoints’, yet the complexities of the mechanisms of knickpoint retreat are often ignored in studies of landscape evolution. This fellowship aims to understand the controls on knickpoint retreat rate and explore the implications for landscape evolution (e.g. channel-hillslope coupling) and other processes that respond through an ‘upstream incision wave’ such as gully erosion, using a range of complementary experimental and numerical modelling approaches. The experimental modelling will isolate the impact of different controls (discharge, knickpoint erosion mechanism, bedrock strength, sediment flux) on knickpoint retreat which will be used to develop an understanding of the key factors that can be used to predict knickpoint retreat through landscapes. This understanding will then be implemented in the numerical landscape evolution code €ros, through the adaptation of the parameters that control knickpoint retreat (currently based on the stream-power incision model assumption that knickpoint retreat scales with drainage area). The model will be run on several mountain landscapes ranging from areas where previous work has identified a strong correlation between knickpoint retreat rate and discharge/drainage area (e.g. New Zealand) to study areas where other factors are thought to be more dominant in controlling the retreat rate (e.g. Iceland). This will improve the understanding of how these landscapes have responded to changes in past changes tectonic/climate forcing, and can also be used to predict how the landscapes will respond to future transient forcing over short and long timescales.

Keywords: fluvial geomorphology waterfalls knickpoints experimental modelling numerical modelling lidar
Microtechnology and integrated microsystems to investigate neuronal networks across scales (neuroXscales)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 3495000.0
EU funding (EUR): 3495000.0
Participants: 1
Project status: CLOSED

To advance knowledge in electrophysiology and information processing of neuronal networks, we propose employing microtechnology and microelectronics to rigorously study neural networks in vitro across scales. Across scales pertains to the spatial domain - from details of subcellular components through single neurons to entire networks - and the temporal domain - from single action potentials to long-term developmental processes. Besides our CMOS-microelectronics-based high-density microelectrode arrays for recording and stimulation, the methodology will encompass patch-clamping directly on the microelectrode chips, high-resolution microscopy, genetic methods, large-scale data handling strategies, and dedicated data analysis and modeling algorithms. We will use mammalian cortical neuron cultures and brain slices. We will potentially have access to every neuron and every action potential. We aim at studying - at the same time in the same preparation - details of specific neurons and subcellular components (somas, axons, synapses, dendrites) in their functional context and the characteristics of the corresponding networks (functional connectivity, emergent properties, plasticity). We will study alterations of components and networks over time and upon defined perturbations and mutual interdependence of network and component characteristics. The high-spatio-temporal-resolution methodology will enable new fundamental neuroscientific insights through, e.g., facilitating investigation of axonal and axonal initial segment signaling characteristics, with the “axonal” side of neuronal activity being largely inaccessible to established methods. It will also enable the mapping of the overall synaptic input to a specific neuron, or the high-throughput monitoring of all action potentials in a network over extended time to see developmental effects or effects of disturbances. Potential applications include research in neural diseases and pharmacology.

Keywords: cmos microsystems,neuro electronic interface,neuronal networks,extracellular electrophysiology of neurons,subcellular resolution,axons,somas
The Dust Devils in Galaxy Centres (DUSTDEVILS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Active galactic nuclei (AGN) are the most powerful objects in the Universe. Their power source is accretion of surrounding matter onto the supermassive black holes in the galaxy centers. During the accretion process huge radiation pressure builds up preventing a large amount of matter to actually fall into the black hole. Instead, it is blown away in polar directions up to kiloparsec scales. Recently, it was discovered that these polar winds are very dusty and form hollow cones and therefore roughly resemble dust devils. This research action aims at investigating this newly discovered dust structures because they have the potential to significantly advance our understanding not only of the AGN phenomenon but contribute to the question of how the feedback on AGN onto their host galaxies works. Specifically, the polar dusty winds could dominate the power output of the AGN in the mid-infrared (MIR) which so far has been firmly attributed to the canonical torus structure. Here, I propose to study the polar dust structures in AGN with unprecedented new observations. First, I want to asses the ubiquity of these structures, and second determine their physical properties including dust composition. The results will be used test whether they are caused by dusty polar wind being launched from the accretion disk and driven by the radiation pressure to large distances. If true, our picture of the nuclear dust structure of the AGN could be transformed from a static phenomenological torus into a highly dynamic structure where the obscuration is caused by the combination of the accretion disk and the base of this dusty wind. This would be a result of high impact in the field and together with the training objectives of this fellowship allow me to reach and demonstrate professional maturity.

Keywords: dust,agn winds,mid infrared,agn torus and unification,agn feedback,high angular resolution,radiate transfer modeling,nearby univserse
Exploring the contribution of bacteriophages to the emergence and spread of antibiotic resistance in environmental settings (ENVIROSTOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-01
End date: 2023-01-21
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Antibiotic resistance has become a global public health concern. Although this phenomenon has been widely studied in clinical settings, its impact has not been extensively explored in environmental settings. The environment is continually exposed to a wide variety of antimicrobials and their metabolites through wastewater treatment plant discharges, agricultural runoff, and animal feeding operations which may contribute to the emergence and spread of antibiotic resistance. Moreover, the large-scale mixing of environmental bacteria with exogenous bacteria from anthropogenic sources provides the ideal selective and ecological conditions for the emergence of resistant bacteria. As a consequence, aquatic environments may provide ideal settings for the horizontal exchange of antibiotic resistance genes. Our working hypothesis is that bacteriophages (phages) play an important (and overlooked) role in the acquisition, maintenance and spread of antibiotic resistance genes (ARGs) in environmental settings, particularly under anthropogenic disturbances. The specific aims of the ENVIROSTOME project are (i) to determine the contribution of phages to the horizontal transfer of ARGs in aquatic environments, and (ii) to investigate the impact of conventional and novel disinfection approaches in wastewater treatment on the prevalence of ARG-carrying phages in aquatic environments. Dr. Balcazár’s group have demonstrated that environmental phages contain a large diversity of ARGs, which warrants further research to clarify their contribution to the emergence of antibiotic resistance among environmental bacteria, as well as to investigate their control through disinfection. The results of this research are expected to deliver critical insights for tackling the global crisis of antibiotic resistance. The project is also supported by an intersectoral secondment with the world-class water intelligence company BlueTech Research and by its founder and CEO, Paul O'Callaghan.

Keywords: horizontal gene transfer,bacteriophages,antibiotic resistance genes,aquatic environments,wastewater treatments,disinfection
Transcriptional regulation by TBX18 in vascular development and disease (TBX18)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-02
End date: 2020-01-01
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Mural cells (pericytes and vascular smooth muscle) enclose blood vessels and are critical for vascular homeostasis. Absence or malfunction of pericytes or vascular smooth muscle results in aneurysm formation in small or large blood vessels, respectively. Our previous work showed Tbx18 is selectively expressed in mural cells of multiple adult organs. Preliminary data indicates that, in mice, ablation of Tbx18 in mural cells results in aortic tortuosity and lethality due to rupture. These observations led to the hypothesis that transcriptional regulation by TBX18 in mural cells is critical for the development of functional vascular networks. To fully understand the roles of TBX18 in mural cells and eventually place it as a gene involved in human vascular disease, we propose to: 1) fully characterize the vascular phenotypes of Pdgfrb- Cre;Tbx18 mutants; 2) identify genes directly regulated by Tbx18 in mural cells; and 3) test a putative involvement of TBX18 in human aneurysmal diseases.

Keywords: vascular disease,aneurysm,vascular development,tbx18,transcriptional regulation,mural cells
All AtlaNtic Cooperation for Ocean Research and innovation (AANChOR)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: Coordination and support actions
Countries involved: Spain,Argentina,South Africa,Germany,Germany,Belgium,France,Portugal,Brazil,Cabo Verde,Portugal
Call: All Atlantic Ocean Research Alliance Flagship (H2020-BG-2018-1, 2018)
Start date: 2018-10-01
End date: 2023-08-31
Duration (months): 59.0
Total project cost (EUR): 4072950.05
EU funding (EUR): 3995892.5
Participants: 22
Project status: SIGNED

The main ambition of AANChOR is to promote the implementation of the South Atlantic Research and Innovation Flagship initiative and the Belém Statement (BS), signed by the EU, Brazil and South Africa in 2017, to upscale research and innovation cooperation within the Atlantic basin, from Antarctica to the Arctic. AANChOR will pursue this ambition by providing the EC and the BS Implementation Committee (to be established by signatories of the Statement) with a framework to identify and contribute to the implementation of concrete long-term collaborative activities, reinforcing international cooperation between Europe and tropical and South Atlantic countries and connecting with the challenges and research needs of the North Atlantic Ocean. AANChOR will be responsible for launching a multi-stakeholder platform to identify collaborative activities, building on national and international ongoing initiatives such as the All Atlantic Ocean Research Alliance and addressing activities aimed at reinforcing capacity building, promoting academia-industry knowledge transfer for an enhanced ocean innovation, developing common standards, enhancing citizen awareness and ocean literacy and converging and aligning R&I infrastructure initiatives. To contribute to the implementation of the identified joint activities, AANChOR will provide seed money for the first development stages of selected joint pilot actions and support the identification of the most appropriate existing funding mechanisms and tools for further development of the selected activities. AANChOR will also define long term measures for the sustainability of the cooperation framework beyond the lifetime of the CSA. Recognising the evolving nature of the BS implementation, flexibility has been incorporated into the structure of the CSA allowing its activities adjustment wherever needed. The consortium brings together partners from 5 European Countries, 2 Latin American countries and 2 African countries.

Keywords: trans atlantic cooperation,marine research and innovation,bel m statement,long term collaborative activities,implementation,convergence,alignment
Better Rural Innovation: Linking Actors, Instruments and Policies through Networks (LIAISON)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Italy,Germany,Belgium,Poland,Switzerland,Norway,Belgium,Bulgaria,Hungary,Hungary,Romania,France,Netherlands,United Kingdom,Portugal,United Kingdom
Call: Optimising interactive innovation project approaches and the delivery of EU policies to speed up innovation in rural areas (H2020-RUR-2017-2, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 4999143.75
EU funding (EUR): 4999143.75
Participants: 19
Project status: CLOSED

LIAISON aims to make a significant and meaningful contribution to optimising interactive innovation project approaches and the delivery of EU policies to speed up innovation in agriculture, forestry and rural areas. Researchers, policy advisors, actors from interactive innovation projects, initiatives and networks, farm/forestry advisors, decision-makers and administrators will jointly investigate the design and implementation of interactive innovation project approaches. Looking with the eyes of a larger number of interactive innovation initiatives we will assess the infrastructure of H2020 and Rural Development Programmes at the project, national and European levels. Central in the project are a 'light-touch' review of the experiences in 200 projects and initiatives, and an in-depth assessment of 32 interactive innovation project approaches in a broad range of agricultural and forestry sub-sectors and countries. We will present the diversity of projects and practices through an online 'story map' with entries from all over Europe and select 15 practitioners from innovation projects who will contribute to the project's analyses and outcomes. LIAISON will produce practice-ready methods, protocols and tools, co-designed in processes involving the target users themselves. These include participatory tools for co-creation and co-learning, for networking, communication and dissemination, impact assessment tools, and methodologies and tools for self-evaluation. An Interactive Online System will help innovation actors to access these. LIAISON will develop detailed best practices and approaches for H2020 multi-actor projects, Thematic Networks, Operational Groups and other interactive innovation approaches that contribute to the implementation of EIP-Agri. All project outputs generated by LIAISON will be subject to a process of validation and fine-tuning based upon practical peer-review by consortium members and other closely involved actors and stakeholders.

Keywords: interactive,multi actor,agriculture,rural development,policy,policy instrument,common agricultural policy,european innovation partnership,social innovation,network,europe