Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Motor Health and Semiotic Function in the Kinesthetic Expressivity of Neurodegenerative Disease (MASKED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Czechia,Netherlands,United States,Iceland,Austria,Canada,Italy
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 1073571.43
EU funding (EUR): 1052100.0
Participants: 11
Project status: SIGNED

Motor Health and Semiotic Function in the Kinesthetic Expressivity of Neurodegenerative Disease (MASKED) is a transdisciplinary applied research project grounded in cutting-edge biosemiotics. The aim is to address Parkinson’s Disease, its symptomatic hypomimia (“facial masking”), and the ever-increasing technological demand for early-indicating detection techniques. Through interdisciplinary, international, and intersectoral secondments, researchers will train in world-leading measurement techniques, including the Facial Action Coding System (FACS) and the Neuropsychological Gesture Coding System (NEUROGES); world-leading measurement technologies, including iMotions’s Affectiva and Noldus’s FaceReader; and advanced computational statistics analysis, including Zipf’s and Menzerath-Altmann’s Laws. In this novel advancement of an applied semiotics that harnesses objective, quantitative methods, MASKED will apply the statistical analysis of empirical laws to scientific measurements of nonverbal behavior. To generate statistical models and interpret semiotic meanings, the project considers the medico-scientific ethics and multi-perspectival values behind the hypomimic sign and its signification across environmental contexts and lived experiences. Both correlational methods and conceptual models play equally critical roles. The objective of MASKED is to develop innovative solutions for noninvasive symptom assessment based on quantifiable differences between healthy and Parkinsonian faces, one face to another, and one face to itself over time. These solutions will have not only long-term applicability across diagnostic, prognostic, and therapeutic disease stages, but also wide-reaching utility across provider, caregiver, and patient treatment stakeholders. The hope with the MASKED project is to improve patient-health outcomes and mitigate socio-economic burdens among families, communities, and societies affected by PD and related chronic, progressive illnesses.

Keywords: facial behavior,automated facial behavior analysis,neurodegenerative disease,early indicating diagnostic techniques,non invasive symptom assessment,empirical laws,hypomimia,facial expressivity,
The Cultures of the Cryosphere. Infrastructures, Politics and Futures of Artificial Cooling (CultCryo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Australia
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-09-01
End date: 2030-08-31
Duration (months): 72.0
Total project cost (EUR): 9911396.0
EU funding (EUR): 9911396.0
Participants: 7
Project status: SIGNED

Artificial cooling fundamentally shapes the world in which we live. Since the onset of the Cold War, cooling and freezing technologies have become increasingly vital for a wide array of everyday practices, from nutrition, health and reproduction to dwelling, telecommunication, scientific research and economic productivity. A global system of cold storages, cold chains and air-conditioned spaces has become an energy-intensive yet barely considered planetary infrastructure: an “artificial cryosphere”. Artificial cold has drastically restructured life both on a biological and social level, yet the far-reaching impact of this technology is still largely unexplored and unresearched. Recent studies estimate that global cooling demand will increase five-fold by 2050, dramatically exceeding our future energy budget and urgently calling for change. CultCryo argues that avoiding the impending global cooling crisis will be impossible if we do not understand how the planetary infrastructure of artificial cold is deeply interwoven in cultural practices. Thus, in order to analyze the constitution of “cryogenic cultures”, we will undertake four interdisciplinary multi-sited case studies in the domains of food supply, air conditioning, biomedicine and computing. We develop innovative approaches using mixed-methods rooted in the history of technology, geography, digital history of concepts, ethnography and the philosophy and ethics of technology. Breaking ground for an innovative interdisciplinary field of research, CultCryo will provide the first geographical mapping of the cryosphere, a historical reconstruction of its emergence, an ethnographic account on its cultural constitution, and a philosophical analysis and ethical assessment of its underlying norms and values. Thereby, we develop a corpus of urgently needed knowledge to critically analyze a pressing global phenomenon while also identifying alternatives towards a more sustainable future of artificial cold.

Keywords: ethnography,technology assessment,language technology,digital history of concepts,cultural analysis,value analysis and theory,cryopreservation,cooling,infrastructures,public health,sustainability,
EU-LAC Strategic Partnership for the Implementation of Digital Dialogues in R&I Cooperation (SPIDER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Spain,Germany,Portugal,Belgium,Chile,Ecuador,Brazil,Costa Rica
Call: R&I cooperation with Latin America (Mexico, Brazil, Argentina, and other countries in the BELLA network or members of RedClara) (CSA) (HORIZON-CL4-2023-HUMAN-01, 2023)
Start date: 2023-11-01
End date: 2026-04-30
Duration (months): 30.0
Total project cost (EUR): 2296835.0
EU funding (EUR): 1996450.0
Participants: 9
Project status: SIGNED

SPIDER aims to support the exploitation of the full potential of the newly established BELLA network and the implementation of the outcomes of EU-LAC dialogues in the context of digitalisation and R&I. SPIDER proposes a multi-stakeholder approach to enable the development of an EU-LAC strategic partnership. SPIDER will engage relevant R&I stakeholders from EU and LAC more actively and strategically in supporting dialogues and creating a common and orchestrated vision and strategy for the exploitation of the full potential of BELLA network and the implementation of the outcomes of digital dialogues enhancing EU-LAC cooperation in R&I. SPIDER will adopt a human-centred and participatory approach, combined with an inclusive and intersectional perspective to support the development of strategic partnerships to stimulate the use of digital technologies that can benefit from BELLA and are relevant for EU-LAC R&I cooperation. At the core of this strategy is the EU-LAC Digital Dialogues Implementation Forum (DIF) that is unique of its kind in international cooperation in R&I and will serve as a multi-stakeholder platform to foster dialogues and exchange of best practices to support the implementation of digital dialogues’ commitments. Furthermore, DIF Working Groups will support the adoption of a human-centred approach to technology development, alongside Diversity, Equality and Inclusion (DEI) principles. Coupled with this, SPIDER will assess the use of BELLA and identify pathways for its future exploitation by engaging key actors of the digital ecosystem in project activities. Moreover, SPIDER will implement a Twinning Programme to foster digital partnerships by connecting EU and LAC innovation hubs that can seize the opportunities of BELLA for digital transformation. On top of that, a cascade of events, including Dialogue Forum events, focus groups, call for ideas, webinars and workshops, demo-days and a final conference will support the project actions.

Keywords: eu lac cooperation,digital and ict dialogues,bella network,dialogues agreements implementation,digital transformation,human centred approach,roadmap,diversity,equality and inclusion dei
Deconvoluting Signaling Activities of Mitochondrial-derived Reactive Metabolites with Unparalleled Depth and Spatiotemporal Precision (mt-REMs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Mitochondria-derived reactive metabolites (mt-REMs) drive context-specific immunomodulatory behaviors during metabolic reprogramming. Yet, no method can interrogate the cause-and-effects of individual mt-REMs with locale specificity and temporal resolution. Mapping mt-REM-directed signaling changes with spatiotemporal resolution would thus be transformational. I will develop a spatiotemporally-resolved in-vivo mt-REM-responsivity-mapping technology. This cross-disciplinary innovation will enable localized build-up of an individual mt-REM in one specific cell type with precise temporal, dosage, and chemotype control. For the first time, I will map cell-type-specific “first responders”, proteins attuned to react with the specific mt-REM in an otherwise unperturbed system, in a manner that alters signaling across distinct disease contexts. My ability to assimilate chemical biology, organic/medicinal chemistry, & biotechnology enables me to achieve these goals leveraging functional mechanistic models principally zebrafish, mice, and cultured primary cells. The resulting new knowledge is biomedically important: my previous work on lipid-derived metabolites supports that we can leverage this information to design drug candidates. This research project promises transformative biomedical advances and technological breakthroughs with enormous potential for unveiling reactive metabolite-guided biological mechanisms influencing cell function & disease outcomes.

Keywords: chemical biology,biotechnology,bioengineering,reactive metabolite signaling subsystem
European Partnership on Innovative SMEs (InnovativeSMEs)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Partnership on Innovative SMEs
Destination: European Partnership on Innovative SMEs
Action type: COFUND actions
Partnership: Innovative SMEs (co-funded)
Countries involved: Belgium,Austria,Portugal,Spain,Germany,Sweden,Italy,Poland,Finland,Hungary,Croatia,Türkiye,Denmark,Norway,Netherlands,Malta,France,Ireland,Cyprus,Israel,Luxembourg,Bulgaria,Czechia,Greece,South Africa,Switzerland,Korea, Republic of,Singapore,Canada,United Kingdom,Estonia,Lithuania,Romania,Slovakia,Iceland,Slovenia,Latvia
Call: European Partnership on Innovative SMEs (HORIZON-EIE-2021-INNOVSMES-01, 2021)
Start date: 2021-09-01
End date: 2029-01-31
Duration (months): 89.0
Total project cost (EUR): 539859964.75
EU funding (EUR): 142112603.26
Participants: 46
Project status: SIGNED

WHO: The proposal involves 40 National Funding Authorities and/or Agencies under the Umbrella of Eureka and is coordinated by the Eureka Secretariat in Brussels. Founded in 1985, Eureka is a global network, with 48 Member States plus the European Commission. It includes nearly all countries of the European continent as well as international members like Israel, Turkey, Korea, Canada, Singapore, South Africa, Argentina and Chile. The Consortium also benefits from the fact that is has successfully run the Eurostars 1 and 2 programs. WHAT: The proposed European Partnership on Innovative SMEs will comprise two main instruments (Eurostars 3 and Innowwide) as well as measures to connect to existing EU programs, initiatives and other European partnerships. EUROSTARS 3 (E*3) is an instrument that supports the international cooperation of SMEs in the field of non-military collaborative innovation projects. An E*3 project consortium must be composed of at least 2 independent entities from at least two participating countries and must be led by an innovative SME. The E*3 instrument benefits from accompanying measures that strengthen SMEs’ ability to access foreign markets like the INNOWWIDE instrument, which has already been piloted with the support of some Eureka network members in recent years. WHY: The biggest challenges for innovative SMEs are the access to international cooperation and to enter international markets as well the ability to receive funding. E*3 through its coordination of national innovation programs will in addition support the further development of a European Research Area. HOW: The Eureka Secretariat will organize two joint transnational calls per year for E*3 and one call per year for Innowwide. National Innovation Agencies actively support the implementation of E*3 via national funding and support measures as well as services to applicants and promotion of the program.

Keywords: global partnership internationalisation innovative smes innovation sme collaborative research close to market international collaboration transnational collaboration sme funding
A breakthrough active immunotherapy for the treatment of osteoarthritis (Anti-IL-6)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 3965000.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Osteoarthritis is a debilitating disease affecting the joint and a leading cause of disability worldwide. It affects at least 250m people and incurs healthcare costs of toward 0.5% of the GDP. Peptinov is developing an active immunotherapy that can halt inflammation-driven destruction of the cartilage in the joints. We use a unique approach to neutralise a key pro-inflammatory protein (IL-6) driving chronic inflammation. Our vaccine-like approach stimulates the patient’s own immune system to produce antibodies against excess IL-6 and neutralise its biological function. By doing so we will halt disease progression. Our treatment will cost 5-10% of conventional immunotherapies as we inject patients with inexpensive, immunogenic peptides to stimulate production of endogenous antibodies. Phase I clinical trial yielded very encouraging preliminary safety and tolerability data on 24 patients. This project will implement the Phase II clinical trial and make our therapy out-licensing ready.

Keywords: na
The Nuclear Frontier: Expanding the Horizons of Protein Glycosylation (SWEETSWAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499926.0
EU funding (EUR): 1499926.0
Participants: 1
Project status: SIGNED

Glycosylation is the most common post-translational modification (PTM), decorating two thirds of secreted human proteins. Often dysregulated in disease, the specific attached glycan influences folding and function. Extended glycosylation is supposed to exclusively occur in the secretory pathway. I propose that this model needs to be revised. My preliminary results—both computational and experimental—question this long-standing dogma and hint at a new kind of PTM: extended glycosylation in mammalian nuclei. I propose a research project that exhaustively determines the presence, biosynthesis, transport, and function of extended nuclear glycosylation as a new group of PTMs. This ambitious project will broaden the areas of cell biology that are modulated by glycosylation, launching many new inquiries into disease-relevant functions of glycans, such as gene expression regulation via glycosylation, beyond the known case of O-GlcNAc. I will measure and probe nuclear glycosylation with a broad array of computational and experimental methods, such as subcellular glycoproteomics, glycomics, glyco-CLIP, data mining, AI, genetic engineering, click chemistry, immunostaining, flow cytometry, and CRISPR/Cas9 knockout screens. My approach is structured into three main aims: (i) rigorously cataloguing which nuclear glycan structures are exposed on which proteins in which cell line/species, delineating a nuclear glycome, (ii) elucidating mechanistically how these molecules are biosynthesized and transported into the nucleus, and (iii) probing the functions of these novel PTMs in human cells. Each aim will further the central hypothesis of nuclear glycosylation and has planned experiments to address aspects from biosynthesis to function. Crucially, this research will resolve several curious observations from decades of glycobiology, leading to the rewriting of textbooks, and open up a new field of study with the function of glycans in nuclear processes.

Keywords: data science,bioinformatics
Novel passivation technique for compound semiconductor devices (ENLIGHT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-05-01
End date: 2024-10-31
Duration (months): 30.0
Total project cost (EUR): 3471750.0
EU funding (EUR): 2430225.0
Participants: 1
Project status: CLOSED

Kontrox is a disruptive technology(24 patents) to improve performance, power efficiency, reliability and manufacturing yields of crucial semiconductor devices like lasers, IR sensors, uLEDs or power electronics. Applied to chips in billions of devices and cars worldwide, Kontrox will have a tremendous impact on global sustainability by reducing their overall power consumption and by reducing the waste generated during their manufacturing. Kontrox is a quantum engineering technique that eliminates oxidation-induced surface defects in semiconductor materials during the manufacturing. Chip surfaces are transformed into high quality nanostructures, eliminating up to 98% of defects and protecting from further oxidation. Integrated into conventional manufacturing techniques Kontrox delivers outstanding device efficiency improvements enabling the next generation and more-than-moore semiconductor devices. We have demonstrated +250% higher efficiency and 90x less power consumption in uLEDs.

Keywords: energy efficiency,environmental and green technologies
Transforming European Work and Social Protection: A New Proactive Welfare State Fit for the Future World of Work (TransEuroWorkS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,Ireland,Denmark,Slovakia,Spain,Switzerland,United Kingdom
Call: Providing support in a changing world of work and social protection (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 2637258.75
EU funding (EUR): 2637258.75
Participants: 12
Project status: SIGNED

For the last two decades, European countries have faced unprecedented structural changes due to digitalisation, automation; the internationalisation of the workforce; and the transition towards a green economy. How national and EU-level interventions will mediate the effects of these transformations will profoundly impact the future of European citizens, the economy, and political stability. TransEuroWorkS' multi-level, comparative, and multi-method strategy for scientific and social impact is driven by an understanding that social protection must be sustainable, inclusive, and mobile to address the complex and interlocking transformations of the near future. The project examines eight policy areas: unemployment, sickness, old-age insurances, retraining, work-life balance, family and care policies, gender equality, foreign labour recruitment and freedom of movement, combining conventional protection policies with the more contemporary social investment approaches. Through research in 27 EU-member states and 2 non-EU countries, we address 5 levels relevant to the transforming world of work and social protection: individuals, households, workplaces, countries and the EU. TransEuroWorkS centres attention on social diversity, including gender, ethnicity, education, employment type, age, and household composition in its methodology. The mixed-methods design of the project, including an original survey on public opinion, survey and field experiments, and interviews with company managers and policymakers, will bring new knowledge on the analysis of existing policies and necessary adjustment measures. TransEuroWorkS will co-design research tools with social stakeholders, engage in policy feedback loops with EU and national policymakers, co-produce innovations and solicit feedback from citizens. Thus, TransEuroWorkS is formulated to bring research with the greatest potential social impact to support Europe's residents and a more cohesive, equal, inclusive, and green future.

Keywords: digitalisation green transition immigration free movement atypical work flexible employment socio economic inequality job transitions work life balance retraining subjective well being