Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pre-designed In situ Oncotherapeutic Nanohydrogel with Enhanced Efficacy for glioblastoma post-Resection (PIONEER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 268568.64
EU funding (EUR): 268568.64
Participants: 2
Project status: SIGNED

Glioblastoma multiforme (GBM) is a grade IV glioma, considered as the most aggressive brain tumor with an average five-year survival rate of 7.2% and projected mortality rate of 46.6% by 2040. The prognosis remains poor, not only due to the severity of the disease but also due to challenges in treatment modality and recurrence. Temozolomide (TMZ) is the preferred anticancer drug for GBM owing to its effectiveness in reducing relapse but the efficacy is compromised by substantial hurdle of drug resistance. My strategy is to overcome this challenge and revolutionize GBM treatment by addressing the obstacles associated with TMZ resistance and prioritizing patient compliance. I hypothesize that combining a small dose of NO-releasing NONOates will activate p53 and inhibit HIF-1, effectively blocking TMZ resistance pathway and significantly boosting therapeutic efficacy. Moreover, NO dilates tumor blood vessels, enhancing the permeation and retention effect (EPR) which increases biodistribution of TMZ within the tumor, promoting apoptosis and oncogenic stress signals thereby reducing the likelihood of tumor recurrence. While the combination of TMZ and NONOates offers numerous advantages for efficient delivery, a major challenge remains: ensuring the transport across the blood brain barrier (BBB) to the tumor site. Here, I also propose the development of an enzyme-triggered injectable hydrogel encapsulating NONOates and TMZ nanocrystals (NCs) designed for post-resection GBM. The enzymatic crosslinking process involves oxidative coupling of catechol groups of tyramine-modified biomolecules, while TMZ NCs will be fabricated via antisolvent co-sonoprecipitation method. The in-situ hydrogel forms rapidly, adhering stably to the resection site, ensuring a targeted and sustained release of TMZ and enhancing efficacy through the synergistic action of NONOates. The combination of NCs, NONOates and enzyme-triggered gelation provides a robust platform for targeted GBM therapy.

Keywords: enzyme triggered gels,in situ hydrogels,gas facilitated systems,nanocrystals,novel gbm therapy,potent antitumor
Comparative-historical analysis of the clausal structure in Reefs-Santa Cruz languages (CHAOCLRSC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: CLOSED

The objective of CHAOCLRSC is to fill a significant gap in the history of Oceanic languages by providing a comparative-historical analysis of the clausal structure in the Reefs-Santa Cruz (RSC) languages spoken on the Reef Islands and Santa Cruz (SC). Despite being classified as Oceanic, RSC show unexpected features, including unusual patterns of clausal structure. In particular, Äiwoo displays a symmetrical voice system, a type of clausal structure which is highly unusual in the Oceanic family. In this respect, Äiwoo differs significantly from the other RSC languages, in that, like most Oceanic languages, they display transitivity-based systems. The presence of a symmetrical voice system in Äiwoo is of interest for the history of the Oceanic subgroup, since voice systems are thought to have been lost in the transition from Proto-Malayo-Polynesian (PMP) to Proto-Oceanic (POc). Recent studies on Äiwoo and SC systems have shown that the two systems are unusual in two different ways. Äiwoo can be seen as ‘transitional’ because it retains a symmetrical voice system with Oceanic morphology, whereas SC languages retain some voice-like characteristics in otherwise largely transitivitybased systems. Historically, the change from PMP to Äiwoo represents one stage of development from symmetrical voice to the Oceanic transitivity-based system, while the differences between Äiwoo and SC may represent a further stage. This makes comparative-historical work on SC clause structures an urgent priority. More broadly, understanding how the shift from a symmetrical voice system to a transitivity-based has happened in RSC will contribute to our understanding of the general principles governing both individual systems and, more generally, the change from one clausal system to the other

Keywords: austronesian languages oceanic languages clausal structure transitivity valency changing morphology grammatical relations austronesian voice systems linguistic typology historical linguistics
Molecular mechanisms through which oocytes evade ageing (ACTIVEDORMANCY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1999796.0
EU funding (EUR): 1999796.0
Participants: 1
Project status: SIGNED

Female germ cells, oocytes, have the remarkable ability to survive for long periods of time, up to 50 years in humans, while retaining the ability to give rise to a new organism. We know surprisingly little about the molecular mechanisms through which oocytes alleviate cellular ageing, and why such mechanisms eventually fail with advanced age. The goal of this research proposal is to reveal both the mechanisms dormant oocytes employ to maintain cellular fitness and how ageing affects these mechanisms, combining biochemical perturbations with imaging and state-of-the-art -omics techniques. We have recently discovered that oocyte dormancy involves two mechanisms not reported in any animal cell type before: the suppression of mitochondrial complex I, and the constitutive activation of mitochondrial unfolded protein response. These discoveries point to a set of poorly understood strategies that oocytes use to minimise damage to their cellular components during their long lifespan. In this project, we focus on three new interlinked directions to reveal mechanisms that dormant oocytes employ to keep a ‘youthful’ cytoplasm: 1) Characterise the metabolic adaptations that enable life without mitochondrial complex I 2) Study extremely long-lived oocyte proteins and their regulation 3) Identify and characterise the quality control mechanisms that eventually fail in dormant oocytes to impact fertility. We will use oocytes from frogs, mice, and humans which are complementary in their ease of handling and relevance to human physiology. One of the biggest problems developed nations face is late-motherhood and associated fertility problems due to ageing oocytes. >25% of female fertility problems are unexplained, pointing to a huge gap in our understanding of female reproduction. This proposal will help fill this gap by studying longevity mechanisms in dormant oocytes. It will further provide insights into the metabolic adaptations of long-lived cells, female fertility, and ageing.

Keywords: oocyte,fertility,dormancy,long lived proteins,mitochondria
Modelling Inter-Scale Energetics in GastroIntestinal ElectroMechanics (MiGEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy,New Zealand
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

The MiGEM proposal targets one of the remaining grand challenges in biomechanics: the development of a comprehensive, inter-scale, thermodynamically and energetically coherent multiphysics model of gastrointestinal (GI) motility. Despite the importance of gastrointestinal disorders as a primary global health problem, electromechanical modelling of gastrointestinal motility still presents significant theoretical and experimental limitations compared to more advanced fields such as cardiovascular bioengineering. Technical difficulties exist due to the intrinsic multiscale nature of gastrointestinal tissues, the coupling of multiple cell types and roles, and the combination of electrical and mechanical phenomena involving different energetic mechanisms. MiGEM has the potential to unlock new frontiers in GI research, addressing several state-of-the-art problems in gastrointestinal motility and opening unprecedented opportunities in novel subject-specific therapies. By adopting a rigorous theoretical-experimental scientific approach, MiGEM will advance state-of-the-art gastrointestinal theoretical modelling and experimental measurements, unveiling fundamental energetic mechanisms that govern stomach and intestine motility in health and disease. MiGEM will enable the first calorimetric measurement of tissue sample from the GI tract and create a new path in biomechanical modelling by assimilating innovative data into multiscale thermodynamic models. The project will create a new network of scientists with complementary experimental and modelling skills, fostering cross-fertilization, providing senior-to-junior methodological transfer, and supporting gender balance. The scientific experience of the PI, the formal membership to the project of the ABI, University of Auckland, and the multiple scientific collaborations that the PI has engaged for many years will be the key elements to successfully carry out an ambitious and high-risk project.

Keywords: gastrointestinal motility multiscale and multiphysics electromechanics energetics heat production measurements theoretical and computational modelling
Dust Study, Transport, and Electrostatic Removal for Exploration Missions (DUSTER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Belgium,France,Spain
Call: Space science and exploration technologies (HORIZON-CL4-2022-SPACE-01, 2022)
Start date: 2023-01-01
End date: 2025-06-30
Duration (months): 30.0
Total project cost (EUR): 1489701.25
EU funding (EUR): 1489701.25
Participants: 4
Project status: SIGNED

International scientific and commercial interests in exploration missions to solar system bodies such as the Moon, asteroids and comets have increased significantly. Several exploration missions are planned in the near future, in particular to the Moon. One major environmental constraint during those missions is the presence of charged dust-like particles, as they can degrade equipment by accelerating wear. Moreover, exposure to and inhalation of dust can have a range of toxic effects on human explorers. There is a recognised need for developing efficient dust mitigation systems. To develop such systems, (i) better knowledge and models of dust charging and transportation in those environments are needed, and (ii) technologies to move charged dust particles in a controlled way must be validated. The objective of the DUSTER project is to develop an instrument for in situ analysis of dust-like particles and their transport in the context of planetary and small body exploration missions. This instrument will be designed to measure for which set of parameters (electrostatic charging of particles, ambient plasma, imposed electric field) dust-like particles can be moved. The technology developed can serve as a basis to design electrostatic dust mitigation devices and dust sample-collecting equipment. The above-mentioned parameters will be determined theoretically and supported by laboratory-based measurements for particles with different properties and under different conditions. Following the requirements derived from the simulations and laboratory measurements, the individual sub-units and units of the proposed instrument will be designed. An integrated breadboard version of the instrument will be manufactured and tested with the same laboratory setup. The target is to reach TRL 4. The development, manufacturing, testing and validation of the instrument will be a joint effort between scientific, engineering and industrial teams with a strong interdisciplinary approach.

Keywords: dust,electrostatic forces,airless bodies and planetary exploration,plasma physics,space instrumentation development,langmuir probes
Versatile FUran-based polymeRs for strIct and high value applicatiOns in packaging, aUtomotive and underwater environmentS (FURIOUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Italy,Spain,Croatia,Germany,Austria,Poland,Netherlands
Call: High performance bio-based polymers for market applications with stringent requirements (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 4498017.5
EU funding (EUR): 4498017.5
Participants: 16
Project status: SIGNED

Τhe goal of the FURIOUS project is to develop novel versatile polymers based on 2,5-FDCA to enrich the portfolio of bio-based innovative mono-material solutions proposed to replace traditional plastics. The materials will be properly designed from the chemical point of view to satisfy a set of target properties required for three stringent applications, where other bioplastics do not address all the requirements or traditional plastics are still widely employed: biomedical and electronic packaging (where resistance to sterilization and high barrier properties are necessary), automotive sector (where resistance to UV weathering and intrinsic antibacterial properties are the key feature) and underwater devices (where photoreactivity and biodegradability in seawater are requested). To target such a goal, all the well-established synthetic strategies will be used, with particular attention to the exploitation of green processes, to low lifecycle environmental impact polymers and to the minimization of their production cost. FURIOUS material versatility will be also assessed with respect to their processability, which is a further mandatory feature to be checked for real entry on the market. Both well-established technologies, such as injection molding and extrusion, and more innovative ones, such as electrospinning, 3D printing and stereolithography will be validated. Last, but not least, intrinsic recyclability will be imparted to the new furan-based polymers for both greener and mechanical recycling and for novel enzymatic recycling strategies. In the case of packaging, compostability will also be evaluated, while underwater sensor biodegradability in marine environment will be checked being one of the key requested polymer feature. Innovative results of FURIOUS will contribute to the development of Sustainability-by-design database, used to assess and predict the performance of novel materials and to derive a set of guidelines for the end-use applications.

Keywords: 2,5 furandicarboxylic acid ad hoc chemical design biopolymer synthesis processability recyclability biodegradation barrier to gases and radiation weathering sustainability
Gender, Conflict and Coercive Control: A Feminist Phenomenological Expansion of Conflict-related Harm (GENCOERCTRL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

GENCOERCTRL is the first transnational empirical theoretical qualitative study of the gendered phenomenon of conflict-related coercive control. Responding to flourishing multi-interdisciplinary interest in physical and sexual forms of conflict-related violence against women (CRVAW) over the last two decades, it reorients scholarship towards the less observationally evident harm of coercive control. Preliminary evidence shows that in conflict settings, women may experience coercive control in the context of informal armed group governance and through the coercive realities of conflict transition, with transitional justice mechanisms critical to making such harms visible for engagement. ‘Coercive control,’ as an invisible but insidious harm, and ‘coercive control’ as a lens through which to understand women’s experiences of conflict, has received little to no scholarly examination. GENCOERCTRL gets ahead of its pending travel into interdisciplinary fields on conflict violence by establishing the basis for the theoretical and empirical expansion of a new field of study of the gendered phenomenon of coercive control. The central research question addresses the multi-dimensional nature of the coercive realities in which women experience coercive control in conflict and transition: How is coercive control in conflict-affected contexts lived and understood by women for whom it is already co-constitutive of their socially coercive realities? It is addressed across four phases: development of a new feminist phenomenological methodology for studying the lived experience of the gendered phenomenon of conflict-related coercive control; generation of unique empirical phenomenological understanding of coercive control in Colombia, Northern Ireland and Sri Lanka; analysis of transitional justice mechanisms in those sites through a coercive control lens; synthesising to develop the first ecological framework for the gendered phenomenon of conflict-related coercive control.

Keywords: conflict related violence against women coercive control gender feminist theory
Computational mechanisms of teacher-pupil knowledge transfer (COMPTEACH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Israel
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

Teaching is one of the most complex and efficient forms for social learning, as it largely mitigates the costs of individual learning through the capitalization of others’ experiences. However, while recent efforts have shed considerable light into how human learning is computationally modeled, very little is known about how human teaching can be computationally implemented in the context of goal-directed behaviours. COMPTEACH is an innovative research program conceived to bridge this gap by combining cutting-edge methods in cognitive science, experimental and social psychology, with state-of-the-art techniques from Reinforcement Learning (RL) and Natural Language Processing (NLP). It aims at understanding the computational makeup of pedagogical knowledge transfer between experienced learners (teachers) and novel naive learners (pupils). COMPTEACH will first identify actors’ choice strategies (as indexed by model parameters) and evaluate the extent to which pedagogical texts crafted by teachers and addressed to pupils lead to meaningful parameter correlations between the two. Secondly, the action will implement NLP tools to identify how the teachers' own computational strategies are encoded in the semantic and syntactic structures of pedagogical texts. Finally, the project will study how the teachers’ own learning process and metacognitive features affect knowledge transfer. By tackling teaching from a computational perspective without losing sight of its socio-cognitive underpinnings, COMPTEACH will produce a novel quantitative understanding of experience transfer, and establish novel bridges between teaching, cognitive science, social psychology and computational modeling. Future directions of this project will involve studying knowledge transfer in individuals afflicted by lasting underlying health conditions, and the development of ecological experiments to approach teacher-student and doctor-patient real-world interactions.

Keywords: human reinforcement learning,computational modeling,teaching,social learning,decision making,behavioral psychology,informational social influence,knowledge transfer,natural language processing