Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Oxidative Stress as a biomarker for Embryo Selection in IVF Process (FERTISSIMO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Israel
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Abstract: Carmel Diagnostics, established in 2009, is an SME that has developed clinical applications of its novel, proprietary, patented Thermochemiluminescence technology platform – TCL Analyzer™. Carmel has successfully completed “proof of concept” for its main applications: Embryo Selection in IVF process and Risk Stratification for CHF patients. The results were published in leading magazines. The technology enables assessment of Oxidative Stress in body fluids using it as a biomarker for clinical problems linked to levels of oxidative stress. TCL Analyzer is a stable, robust Point of Care system, now in its third generation. There is a huge need, clinical and economical, for novel biomarkers that will enable the physicians with effective embryo selection. With the goal of identifying embryos of high implantation probability, Carmel’s non-invasive solution will meet this need by providing a quantitative assessment of an embryo’s reproductive potential based on a biomarker - the oxidative profile of the culture media in which the embryo is incubated. This will allow the practitioner to improve pregnancy rates while reducing the incidence of multiple births. The Phase-1 project will be focused on preparing sound business plan, based on solid business model and commercialization strategy and to plan the activities for deploying the solution. This will include market and competition analysis, IP analysis, supply chain examination, risk assessment, and preparing roadmap for the clinical validation, product completion and the best route to bring the system to the market and launch it successfully. In June, 2014 Carmel won a prestigious grant of GFI - Grant for Fertility Innovation (by Merck Serono) that enabled it to build a series of improved, stable TCL Analyzer units to be used in the clinical studies. Eureka approved the project as well. Carmel’s experienced management is thrilled to build FERTISSIMO, the ultimate Embryo selection system based on TCL Analyzer.

Keywords: biomarker,fertlity,embryo selection,oxidative stress
Quintuple Helix Approach to Targeted Open Innovation in Energy, Water, Agriculture in the South Mediterranean Neighborhood (5TOI_4EWAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Italy,Germany,Egypt,Algeria,Italy,Germany,Italy,Spain,Palestine, State of,Belgium,Libya,Tunisia,Türkiye,Greece,Jordan,France,Lebanon,Morocco
Call: Encouraging the research and innovation cooperation between the Union and selected regional partners – proposals targeting Southern Mediterranean Neighbourhood, Eastern Partnership (H2020-INT-INCO-2015, 2015)
Start date: 2016-05-01
End date: 2019-04-30
Duration (months): 36.0
Total project cost (EUR): 1949914.0
EU funding (EUR): 1949644.0
Participants: 26
Project status: CLOSED

5TOI_4EWAS project will focus on Targeted Open Innovation in energy, water and agriculture societal challenges through a balanced innovation-friendly ecosystem in the Southern Mediterranean Neighborhood (SMN) based on quintuple helix and NEXUS approach. The project will enhance and support regional smart specialization and development by increasing research capacity, effective mobility of young innovators/researchers and shared knowledge to improve their participation in the EU research area. It will contribute to the establishment of favorable and stable conditions for international cooperation and the set-up of a Common Knowledge and Innovation Space of specialization in the SMN for a real socio-economic impact, based on co-ownership and mutual benefits. Our partnership ensures coherence and complementarity with past and on-going regional EU-MPC cooperation initiatives and existing bilateral S&T Agreements. The project allows easily building of synergies among several ongoing initiatives thanks to the established Think Tanks Network of Science Counselors in the MPC area and the observatory of current initiatives. In this way, the project will seek continuous complementarity and coherence with the activities of the Strategic Forum for International Cooperation to enhance the cooperation and close synergies through the involvement of the widest possible range of stakeholders, from funding agencies, research organizations, industry to civil society. Therefore an enhanced and more reliable definition of the priority setting mechanisms in the region from an innovation point of view is expected. Through these activities and by the definition of a Join Action Plan, the project will effectively use the science diplomacy and facilitates the identification of remaining obstacles, conflicts for cooperation and support the R&I bilateral policy dialogue addressing sensitive challenges between EU and MPC through the dialogue and coordination platform that will be created..

Keywords: target open innovation,quintuple helix and nexus approach,balanced innovation friendly ecosystem,regional smart specialization,common knowledge and innovation space
Open OBDII Telematics Platform - OPTEPLA (OPTEPLA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Germany
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The EU is pursuing the political aim to reduce CO2 emissions by 40%, to reduce the number of deaths by car accidents by half and to support methods for more effective use of cars and automobile fleets. The proposed project will provide effective support in reaching these ambitious goals. With OPTEPLA we want to develop an open telematics platform based on the OBDII standard. It consists of a small and cost effective OBDII device for the transmission of the entirely available electronic vehicle data and an open data platform, which receives, formats and analyses these data. There is currently no technical solution in the aftermarket, by means of which for any car manufacturer and for every installed controller device the communications data produced can be exported to an internet environment. For commercialization third party developers will build upon the technology innovative telematics applications such as remote diagnostics and predictive maintenance systems, intelligent driving assistance systems, mapping of CO2 or fine dust concentrations or remote opening/closing car door technology. This technology will be very simple to retrofit to most vehicles. In a development period of only two years, telematics applications based on this platform could quickly experience widespread use and help to make vehicular traffic in the EU significantly safer, more environmentally friendly and more efficient. In the feasibility study of phase 1 we want to find out whether it is technically and economically possible to integrate the complex logic of an integrated vehicle diagnostic system into a miniaturized OBD connector and to reduce its manufacturing costs from currently €120 to less than €10. The expected outcome of the feasibility study is to allow the company to validate its business concept and to make evidence-based decisions about its product viability and market opportunities.

Keywords: telematic,obdii,remote vehicle diagnostics,co2 emissions,driving assistant,car health,driving safety,private car sharing
Low Energy WEt and DrY CAPsule Filling Machine (WEYCAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Founded in Parma, (Italy) in 1974, OPEM S.p.A. is a leader in the design and manufacture ofnbsp; filling and sealing machines for capsules, such as are used for coffee, tea and other beverages, delivering customised production lines to suit the needs of our customers. OPEM has always been committed to ongoing research into innovative solutions for improving the performance and quality of the company’s packaging systems, winning a reputation for products with high efficiency, excellent reliability, easy maintenance and long lifespan. From customers’ feedback and industry trends, we have conceived of an innovative system to produce double compartment capsules, integrating the wet and dry filling operations into a single stage. This is looking ahead to directly address producers#39; demand for new product possibilities. More compact and energy efficient, this is one part of a project to produce a highly adaptable capsule filling machine, designed for lower energy consumption, and to use a variety of materials, including new generation bio-polymer plastics. Our WEYCAP project aims to optimise and revolutionise the capsule filling and packaging industry. We benefit from several key elements that distinguish our machine from others: More complex filling operations via a combined filling unit, leading to new product opportunities, such as wet/dry filling; Adaptability to new capsule shape; Double compartment capsule filling; Lower running costs derived by lower energy and nitrogen consumption; Lower environmental impact as the machine is bio-compostable capsule compatible. Our project, WEYCAP, will lead to long-term profitability for both customers and our company, providing a significantly lower running costs, and generating €11.5m of accumulated profit by 2022.

Keywords: capsule,capsule filling,energy efficiency,packaging
Preventive solutions for Sensitive Materials of Cultural Heritage (SensMat)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Austria,Germany,Italy,Italy,Italy,Italy,Sweden,Sweden,France,France,France,France,France,France,Luxembourg,Denmark
Call: Innovative and affordable solutions for the preventive conservation of cultural heritage (IA) (H2020-NMBP-ST-IND-2018, 2018)
Start date: 2019-01-01
End date: 2022-08-31
Duration (months): 44.0
Total project cost (EUR): 6560705.71
EU funding (EUR): 5976382.5
Participants: 23
Project status: SIGNED

Preventive conservation (PC) has emerged as an important approach for the long-term preservation of sensitive cultural heritage (CH), notably for mobile artefacts, those displayed or stored in harsh environments and for small and medium-sized museums. SensMat aims to develop and implement effective, low cost (<20 – 30€ for basic platform), eco-innovative and user-friendly sensors, models and decision-making tools, as well as recommendations and guidelines to enable prediction and prevention of degradation of artefacts as a function of environmental conditions. SensMat is user-driven (inclusion of 19 museums in the project plus survey of 100 more), and the consortium has solid existing results and a strong capacity to mature the sensors, models and decision-making solutions to TRL 7 during the project. Based on multiscale modelling, data management systems, collaborative platforms and sensor communication networks (IoT), museums stakeholders will be informed in real-time of possible dangers to their artefacts, thus reducing degradation risks and costly conservation treatment. Demonstration of the platform in 10 representative case studies in museums, historical buildings, storage sites and workshops will prepare rapid uptake after the project. Knowledge transfer, training, and recommendations of best practices will facilitate standardization, strategy implementation, new policy definition, and wide-scale adoption of the new solution by cultural heritage sites immediately after the project.

Keywords: preventive conservation,cultural heritage,artefacts,museums,iot internet of things,restoration,micro climate monitoring,multiscale modelling,big data,open data repository,demonstration
PERovskIte Coherent Light Sources (PERICLeS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

PERICLeS target is to develop a new technology in the field of optoelectronics by taking advantage of the exceptional optical and electronic properties of hybrid perovskite semiconductors. The ultimate achievement will be the demonstration of a proof-of-concept solution processed, solid state perovskite-based electrically injected laser with high spectral tunability and low lasing threshold; such device goes beyond the state of the art of the current technologies and will represent a breakthrough in the field, with major impact in communications, sensing, medicine and consumer equipment. The project will start from the design and synthesis of suitable multidimensional perovskites to combine in a single material solution processability, flexibility, high luminescence quantum yield and good charge transport properties. The newly engineered materials will be integrated in laser cavities to confine the electromagnetic field and obtain high Q-factors with excellent control over the spatial and spectral characteristics of the laser beam. Electrically pumped lasing will be achieved through the implementation of the perovskite/resonator system in electroluminescent devices with low fabrication cost and highly compatible with the existing technologies. Beyond the main target, the project will proceed through the realization of intermediate, high impact targets which include the synthesis of new hybrid perovskites with excellent optoelectronic properties, their advanced photophysical characterization and the fabrication of high-efficiency light emitting diodes and transistors. This multidisciplinary project will be carried out at the Italian Institute of Technology (Milan) under the supervision of Dr. Annamaria Petrozza and complemented with a secondment in the nanofabrication facilities at AMO (Aachen).

Keywords: hybrid perovskites,electrically pumped laser,spectroscopic techniques,synthesis of solid state semiconductors
Coat assembly and membrane remodelling: understanding regulation of protein secretion (CRYTOCOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2025-04-30
Duration (months): 66.0
Total project cost (EUR): 1499175.0
EU funding (EUR): 1275036.44
Participants: 2
Project status: SIGNED

Eukaryotic cells are organised in membrane-bound compartments, which have defined chemical identities and carry out specific essential functions. Exchange of material between these compartments is necessary to maintain cell functionality, and is achieved in a highly specific and regulated manner by vesicular transport. To mediate protein trafficking, coat complexes assemble on membranes and couple bilayer deformation with cargo capture into transport carriers. How coat assembly can deliver the flexibility necessary to accommodate a wide variety of cargo proteins, and how the process can be regulated, are outstanding questions in the field. This is exemplified by the COPII coat, which mediates export from the ER of about a third of newly synthesized proteins. COPII assembles into two concentric layers and can form transport carriers of a variety of shapes and sizes, including tubules and spherical vesicles. This is important for export of large cargoes and is a process targeted by cargo-specific regulatory factors. The aim of this project proposal is to shed light on the molecular interactions between coat components, and understand their role in determination of coat architecture and membrane shape. We will use a combination of structural and functional approaches to characterise COPII coat assembly, and its relationship with membranes in systems of increasing complexity, ranging from in vitro reconstitutions to cells. In particular, we will use cryo-electron tomography and subtomogram averaging to understand the architecture of the coat layers in these systems. These are fast-developing techniques that uniquely target complex structures while achieving high resolutions. With my lab at the forefront of current advances, we are perfectly placed to obtain a complete view of the COPII coat assembled on membranes. Our research will answer outstanding questions in the membrane trafficking field and open new perspectives to tackle ill-characterised regulation systems.

Keywords: cryo electron tomography,membrane trafficking,coat protein complex ii
Value chains for disruptive transformation of urban biowaste into biobased products in the city context (WaysTUP!)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Spain,Spain,Austria,Greece,Greece,Türkiye,Belgium,Finland,Serbia,Belgium,Greece,Greece,Greece,Czechia,United Kingdom
Call: Integrated system innovation in valorising urban biowaste (H2020-SFS-2018-1, 2018)
Start date: 2019-09-01
End date: 2023-08-31
Duration (months): 48.0
Total project cost (EUR): 11760021.48
EU funding (EUR): 9348929.35
Participants: 30
Project status: SIGNED

WaysTUP! aims to demonstrate the establishment of new value chains for urban biowaste utilisation to produce higher value purpose products (i.e. biobased products, including food and feed ingredients), through a multi-stakeholder approach in line with circular economy. The project will showcase a portfolio of new ‘urban biowaste to biobased products' processes starting from different feedstocks i.e. fish and meat waste, spent coffee grounds, household source separated biowaste, used cooking oils, cellulosic waste derived from municipal wastewater and waste treatment plants and sewage sludge. Pilot demonstration will take place in several European cities i.e. Valencia (Spain), London (UK), Alicante (Spain), Prague (Czech Republic), Athens (Greece), L'Alcúdia (Spain), Terni (Italy) and Crete (Greece). The processes will result in the production of food and feed additives, flavours, insect protein, coffee oil, bioethanol, biosolvents, polyxydroxyalkanoates, ethyl lactate, long chain dicarboxylic acid, bioplastics and biochar. End-product characterisation and safety assessment will be implemented. Life Cycle Assessment of the value chains will be conducted to assess their environmental impact. WaysTUP! will develop and implement a behavioural change approach with citizens and local communities by improving the current perception of citizens and local communities on urban biowaste as a local resource; enhancing the active participation of citizens in the separate collection of urban biowaste; and improving customer acceptance of urban bio-waste derived products. New profitable business models will be developed preparing market entry of the technology solutions demonstrated as well as of the end-products resulting from them. Finally, the project will provide guidance for city managers on adopting new organisational models supporting the valorisation of urban biowaste, as well as evidence-based EU level policy recommendations for decision makers.

Keywords: urban biowaste,biowaste utilisation
Varieties of Media Effects (VARME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 1495595.0
EU funding (EUR): 1495595.0
Participants: 1
Project status: SIGNED

The overall objective of VARME is to determine the long-term effects of the news media on citizens’ beliefs about societal problems. Theoretically and empirically, the program challenges the prevailing Short-term Media Effects Paradigm that characterizes most research on media effects. In doing so, the program uncovers a variety of important long-term media effects largely ignored in previous research. These include how beliefs about societal problems are initially formed (RQ1), how beliefs are maintained and reinforced (RQ2), as well as under what conditions they change both temporarily and more permanently (RQ3). The ambitious objective of VARME is achieved by three complementary projects. These projects are all possible thanks to an internationally unique infrastructure for data collection at the University of Gothenburg. Project 1 uncovers the long-term processes of media effects over a period of several years. Using an extensive longitudinal mixed-methods design, this study provides unique knowledge on how citizens’ beliefs about society are maintained, reinforced and potentially changed by the news media in the long run. Project 2 clarifies how citizens’ beliefs initially form in response to news coverage. By setting up a novel event-based study, this project enables a close “live” analysis of belief formation as real-world events take place and media coverage unfolds over time. Project 3 focuses on causality and mechanisms behind long-term media effects. Working together with professional journalists, this project is based on a series of realistic experiments on how citizens’ news choices and news exposure influence the maintenance, reinforcement and changes of beliefs over time. Apart from documenting the varieties of long-term effects on citizens’ beliefs about a wide range of societal problems, VARME makes significant contributions to several established theories of media effects.

Keywords: media effects,public opinion,long term