Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart electroactive 3D models of osteoregeneration (SMART-BONE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.32
EU funding (EUR): 173076.0
Participants: 3
Project status: CLOSED

In the European Union alone, the annual number of bone fractures is projected to reach 4.5 million in 2025. Despite the advances in implant technology, grafts prepared using bone extracted from the patient to fill the bone defect are the only material reported so far to retain any significant efficacy in sustaining new bone formation. However, the aging worldwide population and increased life expectancy call for a different answer to the growing need for effective implants for bone fracture healing. The 3D-BONE project will develop an in vitro 3D model to investigate electrical stimulation of stem cells based on biocompatible electroactive 3D scaffolds produced by the ice-templating technique. Electrical stimulation has been shown to positively affect stem cells differentiation into both bone- and vessels-forming cells. One of the key novelty of the 3D-BONE project is the use of human neural crest-derived stem cells (NCSCs). The study of this system in vitro will contribute to increasing the knowledge on a cell population that has the remarkable characteristic of preserving their potentialities to differentiate towards multiple lineages also in the adult. They can thus be isolated from the patient in need of the bone graft, with no need of external donors. Cells’ response to the applied electrical stimulus will be investigated using an organic electrochemical transistor (OECT) that will be integrated in the developed device and will allow for label-free monitoring of cells through an electronic readout. Altogether, the results of these studies will prove beneficial to increase the knowledge on electrically stimulated stem cells differentiation, providing new key tools for the development of implants to be successfully used in critical size defects healing.

Keywords: organic bioelectronics,in vitro models,osteogenesis,stem cells
RISE Social Media Analytics (RISE_SMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Australia,Indonesia,Germany,Germany,Norway,Netherlands,Brazil
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-01-01
End date: 2024-10-31
Duration (months): 70.0
Total project cost (EUR): 1168400.0
EU funding (EUR): 1168400.0
Participants: 10
Project status: SIGNED

The purpose of RISE_SMA is to create an interdisciplinary, international network of excellent scholars and practitioners in the field of social media analytics (SMA). Given the ubiquity of social media, and the immense amount of new social media data continuously created, there is a growing need to derive meaningful insights from this “big” social data by combining different methods. Application areas range from crisis communication and political communication to marketing research and customer acquisition for businesses. The need for more interdisciplinary and international cooperation is especially evident in the two focus areas of RISE_SMA: crisis communication and the societal impact of social media. First, understanding the communication activities unfolding amongst ordinary citizens, and communicating crucial information to them in a timely and coordinated manner during a crisis is a prerequisite for the effective mitigation of its consequences. Practitioners in the field would benefit from more intensive collaboration with researchers, and researchers would benefit from better understanding the needs of decision-makers. At the same time, the wider impact of social media on society is still unclear. Recent advancements in technology have led to the emergence of new communication patterns; their impact and meaning have yet to be understood. On the one hand social media have been highlighted for enabling new forms of citizen engagement that strengthens civic participation at local and national levels, but on the other hand social media have been criticised for enabling the emergence of disconnected echo chambers in which political propaganda can circulate unchallenged. Hence, there is an urgent need for comprehensive concepts as well as methods which exist independent of particular current platforms and applications. Based on research in these fields, practical recommendations need to be derived and technical solutions need to be developed.

Keywords: social media analytics,data mining,network analysis,society,society in crisis,crisis response,management
Medical microbots to support new assisted reproduction techniques (MicroRepro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany,Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 2496141.0
EU funding (EUR): 1975749.07
Participants: 2
Project status: SIGNED

Infertility is a health issue with sociological and psychological implications that affects approximately 50 million couples worldwide and therefore receives global attention. Among fertility issues, male infertility is diagnosed in about 40% of all cases and the major causes are poor motility of spermatozoa (asthenospermia), low sperm count (oligospermia), abnormal sperm morphology (teratospermia) and/or combinations of these, leading to their inability to fertilize an oocyte. Such problems have been mainly addressed by artificial insemination (AI) and in vitro fertilization (IVF). AI involves introducing sperms into a woman’s uterus with a medical instrument, but its applicability is limited and its success rate is below 30%. In contrast, IVF and intracytoplasmic sperm injection can be more effective but implicate more invasive procedures such as removing oocytes from a woman’s ovaries, fertilize them outside of the body and then transfer the embryos back to the uterus a few days later. These difficulties demand rethinking of assisted fertilization and the sought after novel approaches that offer more natural procedures with high success rate. Hence, we propose untethered medical microbots to assist sperm cells to fertilize an oocyte in living organisms (mice model). The MicroRepro project will bring advances in areas such as bioimaging, nanomaterials science and fundamental biology, boosting the whole field of medical microbots in the process, as was recently highlighted by the PI in an extended comment [Nature 545, 406(2017)]. The PI has decisively contributed to the field of microrobotics and invented the sperm-robot (Spermbot) concept together with his team in two previous patent applications and several publications. The mere concept has attracted worldwide attention. However, even in vitro fertilization has never been achieved – therefore, targeting the challenges leading to the first spermbot fertilization will be the main objective of this project.

Keywords: in vitro fertilisation,micromotors,microrobotics,deep tissue imaging,nanomedicine
Carbonate boundstone as a geochronometer (CARBCHRON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Recent analytical developments are reinvigorating the study of carbonate as a geochronometer in deep time (>1 Ma) using the U-Pb system. Boundstone, a type of carbonate rock made by the trapping and binding of carbonate sediment by microbial mats, is often sampled for use in U-Pb dating of carbonates. It has even been used as a reference material in recent studies. However, we lack a process-based understanding as to why boundstone works so well for geochronology, and which geological processes create the material we date. This work, supervised by Dr. Axel Gerdes at Goethe University Frankfurt, investigates these questions. This project tests a hypothesis, supported by early results, that microbially-induced carbonate precipitation under reducing conditions creates geochronologically viable early cements. This hypothesis will be tested by petrographically, geochemically, and geochronologically characterizing boundstones from Earth’s last 1 Ga. To test the accuracy and robustness of the boundstone chronometer, I then will compare boundstone dates with radiometric ages derived from zircon and black shales in two stratigraphic succesions: the Neoproterozoic of Oman and the Ordovician of Anticosti Island. First, boundstone samples will be characterized petrographically. High-throughput laser ablation inductively coupled mass spectrometry (LA-ICP-MS) will be used to geochemically and geochronologically characterize samples, a subset of which will advance to high-precision dating by isotope dilution (ID).

Keywords: u pb carbonate geochronology
Psychobiological mechanisms of pain persistence (PainPersist)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2026-12-31
Duration (months): 72.0
Total project cost (EUR): 2498294.0
EU funding (EUR): 2498294.0
Participants: 1
Project status: SIGNED

Persistent or chronic pain is a key medical and societal problem. In the last decades, biomedical research has undertaken enormous efforts to develop treatments for persistent pain, but the results have been disappointing. This project proposes a radical shift, namely to target the early development of pain persistence and to investigate psychological interventions directed at negative expectations, control and reward in experimental long-term pain studies. A methodological work package will develop novel tools, such as MR spectroscopy of the spinal cord, to track metabolic changes related to persistent pain, and to identify the mechanisms of the proposed interventions. All studies are guided by an integrative model outlining how psychological factors, such as negative expectations and loss of control, can affect the development of pain persistence, and more importantly, how to counteract this process. We will, for example, augment the perception of pain decreases by expectations or use reward manipulations to reinstantiate the effectiveness of the pain modulatory system. Finally, the model proposes that the inability to control pain leads to a state of helplessness. Consequently, the role of helplessness will be investigated and we will test interventions with the goal to allow subjects to regain control over their pain. This will be possible, through the development of a novel pain assessment device, which can be used to detect spontaneous pain decreases and prompt the subject to perform an action (i.e. self-administer a putative treatment). Through the illusion of control, subjects perceive that their action is causal for the pain relief, even though it is actually pain reductions that trigger their action. In the future, this will also allow treatment of patients in which pain is already persistent, and allow them to regain perceived control over, and hence reduce, their pain.

Keywords: pain,cognitive neuroscience,neuroimaging
European Programme for Accelerating the Take up of Sustainable Urban Mobility Plans (SUMPs-Up)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Germany,Germany,Belgium,Bulgaria,Greece,Hungary,Finland,Sweden,France,United Kingdom
Call: Strengthening the knowledge and capacities of local authorities (H2020-MG-2015_TwoStages, 2015)
Start date: 2016-09-01
End date: 2020-02-29
Duration (months): 42.0
Total project cost (EUR): 3999921.25
EU funding (EUR): 3999921.25
Participants: 16
Project status: CLOSED

Through SUMPs-Up, an experienced consortium of public and private organisations, including four major city networks and seven frontrunner cities, skilled in coordinating major European SUMP projects will accelerate the take-up of SUMPs, where this is currently low, ensuring that SUMP is the primary mobility planning concept in Europe. To achieve this, the project will combine comprehensive SUMP research, tailored capacity-building, strong mechanisms for technical support, as well as constant SUMP monitoring and evaluation. As a result, the project will accelerate the development of 100 SUMPs, reach out to 600 cities and will therefore engage about 80% of the EU-cities above 50,000 inhabitants. SUMPs-Up will review, strengthen and integrate existing SUMP resources, designing a support system to assist cities to develop high quality SUMPs. A SUMP Tool Inventory will help mobility planners make better informed decisions about which planning tools to apply in their local context. This will be enriched with experiences from the city partners who will be testing innovative solutions in SUMP preparation and implementation. The SUMPs Up Innovation Pilot Pool will create a mechanism that allows identifying and validating the most effective concepts, approaches and methodologies in SUMP practice for different framework conditions and different types of cities, complemented by a peer learning programme, to leverage resources and enable more cities to apply the SUMP concept. At Member State level, SUMPs-Up will foster exchange to improve national SUMP frameworks. Close monitoring and evaluation of the project and supported activities will show evidence of the SUMP concept’s value and serve as a quality control mechanism for both project activities and the SUMPs being developed. SUMPs-Up will broadly communicate the positive impacts of SUMPs, producing and disseminating insightful reports and research. Ultimately, SUMPs-Up will stimulate a European movement of mobility planning authorities experienced in preparing and implementing SUMPs in compliance with the European requirements.

Keywords: promoting take up,city activation,european movement,tools review for sump planning process and measures,peer to peer exchange,activity fund,comprehensive communication and outreach
Storage Research Infrastructure Eco-System (StoRIES)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: European Green Deal challenges
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Italy,Italy,Italy,Austria,Germany,Spain,Spain,Italy,Germany,Cyprus,Belgium,Switzerland,Norway,Finland,Norway,Norway,Finland,France,France,France,Czechia,Netherlands,Denmark,United Kingdom
Call: European Research Infrastructures capacities and services to address European Green Deal challenges (H2020-LC-GD-2020-6, 2020)
Start date: 2021-11-01
End date: 2025-10-31
Duration (months): 48.0
Total project cost (EUR): 7001439.41
EU funding (EUR): 6999980.0
Participants: 36
Project status: SIGNED

According to the European Green Deal goals, new energy storage technologies will supply more flexibility and balance in the grid, providing a back-up to intermittent renewable energy and contribute to seasonal energy storage challenges. Above all, the main challenge for energy storage development is economic. In order to achieve more performing, competitive and cost effective energy storage devices, the project fosters a European ecosystem of industry and research organisations on energy storage technologies aimed at developing novel concepts and technologies. StoRIES brings together a consortium of 32 beneficiaries from 17 countries: ESFRI facilities, technology institutes, universities and industrial partners to jointly improve the economic performance of storage technologies. Members of the European Energy Research Alliance and from the industry lead European Association for Storage of Energy are establishing the core of this world-class European ecosystem. The main objectives of StoRIES are linked to the energy storage development by providing access to world-class research infrastructures and services, with a focus on improving materials for devices and optimizing hybrid energy systems with a view to make energy technologies more competitive and reducing costs. In addition, StoRIES focuses on the analysis of socio-technical and environmental aspects of new developments and systems and provides training and education on these issues. By promoting complementary expertise, interdisciplinary cooperation and a broader exchange of knowledge and technologies throughout the academic world and with industry, StoRIES will significantly improve the technological basis for energy storage applications. Furthermore, StoRIES will establish an ecosystem with international peer partners from Research and Industry to foster open science and promote new energy technology standards.

Keywords: hybrid energy storage,research infrastructures,materials,energy storage ecosystem
Take Control (TaCo)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Italy,Malta,France
Call: Automation in ATM (H2020-SESAR-2015-1, 2015)
Start date: 2016-06-20
End date: 2018-06-19
Duration (months): 24.0
Total project cost (EUR): 599992.5
EU funding (EUR): 599992.5
Participants: 3
Project status: CLOSED

TACO aims to define an automated system sufficiently powerful to both accomplish complex tasks involved in the management of surface movements in a major airport and self-assess its own ability to deal with non-nominal conditions. When needed, such system should be sensitive enough to transfer responsibilities for traffic management back to the controller, in a timely and graceful manner and in way that makes him/her comfortable with the inherited tasks. Automation is one of the key solution proposed and adopted by SESAR to tackle the challenges coming from the increase of capacity and complexity of the future ATM system. On the one hand, the programme aims at substantially reducing controller task load per flight through a significant enhancement of integrated automation support, whilst simultaneously meeting the established safety and environmental goals. On the other hand, it is envisaged that human operators will remain at the core of the system (mainly with the role of overall system managers) using automated systems with the required degree of integrity and redundancy. TACO proposes a dove tailed process to facilitate the controller’s forward thinking, also in anticipation to A-CDM (Airport- Collaborative Decision Making) amongst others. Following the two grounding principles of automation in SESAR, TACO project aims at: defining algorithms and solutions to automate and optimize both the decision making and implementation tasks for the controller involved in the ground movement of airport vehicles and aircraft; identifying and providing the controller with suitable and usable tools to supervise (monitor, tune and re-program) the system; studying the interaction between the human actors and the automation. Main focus will be on the identification of sensitive state transaction from a (fully) automated management system to conditions where the human is brought into the loop to handle situations where his/her cognitive resources are essential.
Innovative compact HYbrid electrical/thermal storage systems for low energy BUILDings (HYBUILD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Italy,Italy,Austria,Italy,Austria,Austria,Austria,Germany,Italy,Cyprus,Greece,Switzerland,Greece,France,France,Czechia
Call: Highly efficient hybrid storage solutions for power and heat in residential buildings and district areas, balancing the supply and demand conditions (H2020-EEB-2017, 2017)
Start date: 2017-10-01
End date: 2022-03-31
Duration (months): 54.0
Total project cost (EUR): 5995840.0
EU funding (EUR): 5995840.0
Participants: 26
Project status: CLOSED

HYBUILD will develop two innovative hybrid storage concepts: one for the Mediterranean climate primarily meant for cooling energy provision, and one for the Continental climate primarily meant for heating and DHW production. HYBUILD action is a systematic approach for developing operationally integrated thermal and electric components and systems from TRL4 to TRL6 and beyond. The hybrid storage concepts are based on: a compact sorption storage, based on a patented way to integrate an innovative adsorbent material within an efficient high surface heat exchanger, a high density latent storage, based on a high performance aluminum micro-channel heat exchanger with additional PCM layers, and an efficient electric storage. The balancing of thermal and electrical energy flows will be realized by seamless integration of electric building components in a DC coupled system and by efficient conversion and upgrading of electric surplus and renewable thermal energy sources by compression and adsorption heat pumps. The components will be integrated to realize the full-scale hybrid storages (with overall volume between 1 and 2 m3), which will be properly managed by advanced control and building energy management systems (BEMS), able to optimize the interactions between components and district network. Such a configuration will allow reaching energy savings ranging between 20 and 40%, on yearly basis, both in Mediterranean and Continental climate for non-connected and district-connected buildings. HYBUILD hybrid storages will be used to upgrade existing building configurations and monitored in three different demo sites in near-life operation, both for non-connected and district-connected buildings in different climates.

Keywords: sorption thermal storage,latent storage,smart control systems,hybrid electrical,thermal storage,mediterranean and continental application