Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cooperative Synthesis by Molecular Deconvolution (CoSyMoDe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1919687.0
EU funding (EUR): 1919687.0
Participants: 1
Project status: SIGNED

The past six decades have seen awe-inspiring progress in the science of synthesis. In academia, the assembly of complex molecules (natural products) still poses a challenge, but is no longer a limitation. Yet, application of natural products in industry is still limited. This limitation is reflected by a lack of novel lead structures with a new mode of action — one of the main challenges pharmaceutical industry faces today. With complexity still being a challenge but no longer the limitation, natural products and their unique structures are now ideally suited to fill this gap. However, “target oriented synthesis” (TOS) still dominates the synthetic community, but is not suited for structure diversification. This imposes a poor “return on investment” (ROI) to natural product research in industry. The diminished ROI of TOS is owned to tailor made synthetic routes, strictly applicable to a single molecule with no flexibility, and thus disproportionally increasing time and financial efforts in the search for new lead structures. In this research proposal, the applicant devises an alternative strategic concept termed “Cooperative Synthesis by Molecular Deconvolution” (CoSyMoDe), providing an alternative to TOS, and thus serves as a versatile tool for lead structure discovery. In contrast to TOS, CoSyMoDe targets the most complex congener (alpha) in a set of natural products. All other congeners are obtained by synthetic deconvolution of alpha, rendering the overall process more facile, additionally providing access to a whole set of targets, and thus improving the ROI. To showcase the versatility of CoSyMoDe we have picked one of the most challenging, bioactive, and prominent set of target structures, the taxane diterpenes. Amongst them “cyclotaxanes”, are most complex, and have eluded their total synthesis up to date. We will demonstrate the potential of CoSyMoDe, by solving this synthetic conundrum and thereby push the limits of organic synthesis.

Keywords: total synthesis,natural products
SmartClouds Orbital Dynamics and Control (SmartCloudsODC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2019-06-22
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This Action, entitled “SmartClouds Orbital Dynamics and Control” (SmartCloudsODC), will deliver radical new methodologies for orbital dynamics and control of multi-spacecraft systems to investigate new easy-accessible space-based products and services for Europe. Thanks to the advanced in Miniaturised Electromechanical Systems technology, a new class of low-cost, low-risk space missions - based on multiple cooperative elements - is arising. Assuming smart-clouds of vast numbers of femto-spacecraft, this Action will move from the classic - deterministic - celestial mechanics approach to a new paradigm in space mission design - based on stochastic analyses. Through the excellent inter/multi-disciplinary quality of the training by world’s leading academic experts in Astrodynamics at the Institut d’Estudis Espacials de Catalunya, this Action offers novel research methodologies and solutions to orbital dynamics problems including real-world uncertainties. Moreover, a crucial inter-sectoral Secondment at Dinamica Srl, a highly specialized Italian SME in space mission design at large, generates an ensemble of knowledge and resources, enabling the Experienced Researcher to fully develop his potential. This Action will enhance the ER capabilities to devise radical new space concepts in order to broad space-access to a wider European user’s community, also beyond the Aerospace sector, at extremely low-cost. The opportunities offered by this Action will boost the ER’s career allowing him to emerge as an independent researcher and as a leading actor in the game-changing the space sector.

Keywords: femto spacecraft,orbital dynamics and control,uncertainty management,space based applications
Education and Wellbeing of Youths in Secondary Schools: A Comparative Analysis of Teaching Styles and Happiness in Japan, France, and Finland (EduWell)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

Do teaching styles affect students’ happiness? Despite a plethora of studies on a variety of factors and youth happiness, we do not yet grasp possible influences of teachers’ teaching methods on student happiness. This project, EduWell, aims to (i) understand the relationship between different types of classroom teaching styles and youth wellbeing, and (ii) contribute to a more nuanced approach in scientific and policy comparisons of students’ experiences and subjective evaluations of happiness across three national contexts: Japan, France, Finland. This is an important issue because, even among rich countries today (i.e. OECD members), a sizeable number of youths are unhappy in schools. The research aim (i) will be achieved by data collection and analysis (interviews/focus groups with students and teachers, classroom observations) in selected secondary schools in Tokyo, Paris, and Helsinki. Each case study has a dominant, distinctive teaching style: from more hierarchical (France) to more participatory (Finland) to hybrid (Japan), so that context-dependent youth happiness can be discerned. The research aim (ii) will be achieved with assistance from the two secondment hosts. Active in education consultancy and policy advice respectively, the two secondment hosts undertake to help exploit and communicate research outputs to curriculum planners in Finland and policy advisors in France. Lastly, this EduWell project is relevant to the Horizon 2020's work programme on "Health, demographic change and wellbeing" (societal challenge 1). With ageing population and shrinking numbers of youth in much of the developed world, the young has to live with such consequences longer than adults. Hence, understanding their happiness at the most formative stage of growing up, and to make relevant education policy adjustments when necessary, enhance the long-term state of wellbeing of today's youth in their adulthood.

Keywords: happiness research most relevant to project,area studies japan europe,teaching styles in classrooms
In-line quality inspection system for smart production of micro and nanoelectronic components (INLINETEST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Germany,France,Netherlands
Call: Micro- and nanoelectronics technologies (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-11-30
Duration (months): 47.0
Total project cost (EUR): 1762631.25
EU funding (EUR): 1332916.88
Participants: 5
Project status: CLOSED

Future micro/nano-electronics components production will need to be smart and provide instantaneous information on all items for complete traceability. This is necessary as enormous quality requirements have to be met by industrial manufacturers to be competitive in this growing multi-billion market. The crucial ingredient for this development is the availability of rapid in-line-capable inspection systems to unequivocally detect production flaws and defects in the component. To respond to these challenges, the fast, contactless and non-destructive full-field thermometric methods of Pulse-Infrared Thermography (PIRT) and Thermoreflectance (TR) are exploited for the first time to enable 100% in-line inspection in the production line. INLINETEST’s objective is to take up these challenges in design, realization, deployment and test: Existing prototypes for both methods will be adapted and upgraded to the challenges of inline testing, enhanced by hard- and software innovations. For validation under real-life conditions, both failure analytical method’s hard- and software will be customized and integrated into two production lines and demonstrated on two encapsulated power multi-chip module (MCM) components and one in-line production tool at the project partners, covering crucial aspects of the avionics, telecom and automotive sector. The consortium, composed of five partners from industry, SME and academia from 3 European countries, pools excellence and interdisciplinary skills to address these tasks. We are convinced that INLINETEST will enable the first in-line-capable inspection system for 100% monitoring of micro/nano-electronics production based on the thermographic methods of IR and TR, meet the aggressive precision and efficiency targets presented in the proposal and hence boost productivity and radiate out to other lines and products where non-contact failure analysis below surfaces of various emissivity is needed. Thus, the route for smart production is pre

Keywords: in line inspection,failure analysis,infrared thermography,thermoreflectance,packaging,microelectronics,nanoelectronics,sintering,die attach
Weaving Technology based Automated Production Processes in the Composite Industry (We TAP IN) (We TAP IN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Netherlands
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2016-01-31
Duration (months): 7.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Weaving Technology based Automated Production Processes in the Composite Industry (We TAP IN) project aims at a commercial validation of high quality unidirectional glassfiber / polymer composite tape mass production technology and commercialization. Industry development The composite industry is a fast growing and widely expanding industry. The majority of all commercial composite product are based on thermosets. Thermosets can not be separated in the original fiber and matrix materials. Hence reuse or recycling is hardly possible. Within a few years the lack of recyclability imposes an undesired situation. Problem Mass production is required to server high volume commodity products and markets. Mass production require advanced automated production processes which requires thermoplastic tapes as semi-finished product. Current thermoplastic tapes are of limited quality, hampering the shift towards increased recyclability. Intended Innovation Years of involvement in the industry and the development of thermoplastic unidirectional tapes production processes resulted in an improved production method. The production method is based on an industry knowledge cross-over. The realization of a full scale mass production facility will be realized with an incumbent textile manufacturer, by means of a joint venture. Benefit Once commercial available, the innovation contributes to a increased recyclability of new composite products. The use of high quality thermoplastic tapes will reduce weight in several products of high volume markets. The realized weight reduction of the products will result in a decrease of CO2 emission during the transportation and during the lifetime of products. Effect The innovation bridges the gab between, low cost medium quality raw materials and advanced automated production processes. As a result high volume market can be targeted and a contribution can be realized on a knowledge intensive manufacturing base in Western Europe.

Keywords: composite industry,automated production technology,weaving technology,technology cross over,textile industry,fiber optic industry,thermoplastics,unidirectional tapes,glass fiber thermoplastic
New insight into the origin of the Earth, its bulk composition and its early evolution (ISOREE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 2200000.0
EU funding (EUR): 2200000.0
Participants: 1
Project status: CLOSED

The main geochemical features of the mantles of terrestrial planets and asteroids can be attributed to differentiation events that occurred during or shortly after the formation of the Solar System. Numerous questions remain regarding the Earth’s bulk composition and the most likely scenario for its evolution prior to the last major differentiation event caused by a giant impact leading to the formation of the Moon. The aim of this five-year project is to evaluate the state-of-the-art models of the Earth’s early evolution with the following main objectives: (i) Defining precisely the age of the Moon’s formation, (ii) Refining the giant impact model and the Earth-Moon relationship, (iii) Dating the successive magmatic ocean stages on Earth, and (iv) Constraining the Earth mantle’s composition in terms of rare earth element concentrations. These different questions will be addressed using trace elements, radiogenic isotopic systematics (146Sm-142Nd, 147Sm-143Nd, 138La-138Ce) and stable isotopes. ISOREE is a multi-disciplinary project that combines isotope and trace element geochemistry, experimental geochemistry and spectroscopy. A large number of samples will be analysed, including terrestrial rocks with ages up to 3.8 Ga, chondrites, achondrites and lunar samples. This proposal will provide the tools to tackle a vast topic from various angles, using new methodologies and instrumentation and promoting innovation and creativity in European research. This research program is essential to further constrain the major events that occurred very early on in the Earth’s history, such as the Earth’s cooling, its crustal growth, the surface conditions and development of potential habitats for life.
Imaging synaptic plasticity by ultra-high field magnetic resonance spectroscopy in health and psychiatric disease (SYNAPLAST MR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1505000.0
EU funding (EUR): 1505000.0
Participants: 1
Project status: CLOSED

A large number of psychiatric disorders (major and bipolar depression (MDD / BD), schizophrenia, obsessive-compulsive disorder (OCD), addiction, anxiety, attention deficit hyperactivity syndrome (ADHS), posttraumatic stress disorder (PTSD), autism) lack objective criteria for primary diagnosis, early differential diagnosis with regard to subtypes in treatment response and disease progression or effective therapy monitoring. Hence, the search for relevant biomarkers is of high importance. This proposal suggests the development of novel methodology for highly spatially and temporally resolved imaging of disease effects on neurotransmission, membrane processes related to synaptic plasticity and brain energy metabolism in psychiatric disorders and the acute and chronic impact of related pharmacological treatment in the human brain. To that, the advantages of a unique 9.4 T whole body human magnetic resonance imaging (MRI) system for 1H, 31P and 13C magnetic resonance spectroscopic imaging shall be exploited. Highly innovative enabling MRI technology including parallel transmission, very high order B0 shimming, a real time field stabilization and motion correction approach along with the principles of advanced encoding and non-Fourier image reconstruction shall ensure high data quality. Next to obtaining 20 novel image contrasts based on steady state metabolite concentrations, the ultimate goal of the proposed research is to enable functional spectroscopic imaging in the entire human brain in order to investigate adaptation of neurotransmission and brain metabolism to environmental stimuli as well as the impact of acute pharmacological intervention. Finally, the spatially and temporally resolved metabolic imaging technology shall be used for investigation of patients with major depressive disorder to reveal novel biomarkers relevant for diagnostics and patient stratification.

Keywords: magnetic resonance spectroscopy,ultra high field,9 4 t,14 1 t,positron emission tomography
Urban Gamification for City Reappropriations (ReClaim)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-04
End date: 2020-09-08
Duration (months): 24.0
Total project cost (EUR): 191325.6
EU funding (EUR): 191325.6
Participants: 2
Project status: CLOSED

In a grey, but not yet cold, autumn day, people walk through the city centre minding their own business, looking at the pavement and ignoring the other passers-by. Then something happens: they stop abruptly, they appear perplexed, for a moment and then, slowly, their eyes are filled with awe: someone is playing some games over there, in the city streets! The citizens' reaction to moments of urban playfulness is often the same: a simple, almost childish, joy at seeing the anonymity of modern cities being invaded by coloured, fun and light-hearted activities. Nowadays, the idea that cities should not just be smart, but also playable is gaining more and more recognition. Pro-social activities such as those organised by the Watershed of Bristol try to channel the power of city play (already exploited by bottom-up, spontaneous activities such as parkour, flash-mobs and zombie walks) and use it to promote more inclusive communities and a sense of city-ownership. This proposal aims at studying urban play in the wider frame of gamification, in order to deepen our understanding on how we can use play to affect the urban spaces and on what effects this might have on the citizens and their practices. The project draws from the knowledge and methodologies of gamification, critical design and pervasive play and aims at building an innovative and usable methodology. The latter will be tested through the analysis of case studies and through empirical testing, thus allowing the ER to build a framework for the study and design actions of urban gamification. ReClaim will be carried out within the Gamification Group of Tampere University of Technology (the most published and cited group on the topic) and during a secondment at the Watershed of Bristol (home of Playable Cities). This, together with the numerous actions aiming at the communication to the general public, will ensure the maximum chances of success to the project and of dissemination of its results.

Keywords: gamification,playfulness,playable city
Next Generation Imaging (NGI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-09-01
End date: 2021-07-31
Duration (months): 23.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Next generation sequencing has led to revolutionary discoveries in the fields of genetics, genomics, epigenetics and transcriptional regulation. The main limitation of this technology relies on the loss of spatial information: NGS is unable to retrieve the organization of nucleic acids (DNA/RNA) in the cell or within the more complex structure of the tissue. We have recently developed a novel imaging-based technology, Hi-M, that enables the simultaneous detection of tens of DNA and RNA species in single cells within the context of intact tissues. In NGI, we propose to make major improvements to drastically reduce data acquisition and analysis time, considerably increase throughput and number of independent nucleic-acid species detected, and improve the robustness of acquisition and the user-friendliness of analysis. These objectives will be achieved by implementing, testing and validating a novel combinatorial labeling scheme, parallelized acquisition, improvement of the liquid-handling robot to handle hundreds of independent species, and on-the-fly analysis using deep learning technologies to provide more robust data analysis pipelines and adapt acquisition parameters in real time. These improvements will enable simultaneous detection of thousands of species (DNA, RNA or protein) in single-cells with spatial resolution within the context of complex organisms and tissues. Because of these important advantages over existing technologies, NGI will be key to future discoveries in the fields of genetics, genomics and transcription. Critically, NGI will also have a large impact in other fundamental and applied fields where knowledge of spatial organization of transcription and 3D chromosome organization at the single-cell level are relevant: neuroscience and neurological diseases, diabetes, cancer, etc. Thus, NGI has the potential to become an ubiquitous tool not only in academic science but also at the clinic.

Keywords: single cell,transcriptomics,genomics,chromosome architecture,high throughput optical microscopies,tissue atlas