Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Harnessing the power of enzymatic oxygen activation (OXYTRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany,Germany,Italy,Austria,Norway,Norway,Türkiye,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-03-31
Duration (months): 51.0
Total project cost (EUR): 3076435.64
EU funding (EUR): 3076435.64
Participants: 15
Project status: CLOSED

For the selective and effective incorporation of oxygen into biological molecules (oxygenation reaction), several enzyme types have evolved in nature. They catalyse crucial reactions in various metabolic routes. The chemistry feasible with these biocatalysts is unrivalled when compared with conventional chemical methods. Therefore, these oxygenating enzymes are very promising tools in biotechnological approaches. However, when compared with other enzyme classes, such as hydrolases, oxygenases are still in their infancy considering their biotechnological potential. To fully exploit the catalytic power of oxygenases, several hurdles have to be taken for which a higher level of knowledge on these enzymes is needed while also technical aspects have to be solved. The European Training Network (ETN) OXYTRAIN is a joint academic/non-academic training initiative supporting the convergence of biochemistry, enzyme engineering and biotechnology. The consortium's mutual goal is developing a new generation of innovative and entrepreneurial early stage researchers (ESRs) to satisfy the need for knowledge and skills to produce and apply oxidative enzymes. This will be achieved by setting up a network and intersectoral programme in which multiple disciplines will be integrated and exploited. By bringing together 7 academic beneficiaries that are experts in the field of individual oxygenase groups, the network will provide perfect conditions for cross-fertilization of knowledge, while the 3 industrial beneficiaries and 5 partner organisations will add to the consortium by translating the generated knowledge into real industrial applications, such as textiles, pharmaceuticals and biorefineries.

Keywords: biocatalysis,enzymology,biotechnology,enzyme engineering,monooxygenase,cofactor
Molecular Basis of Tubulin Transport During Cilium Formation (ciTTub)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-08-07
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

Cilia are essential hair-like structures presented at the surface of eukaryotic cells that allow motility, fluid flow and complex inter- and intracellular signalling events. Nine pairs of microtubules organized in a cylindrical shape called axoneme form the backbone of cilia. The formation and maintenance of cilia is dependent on a multi-subunit protein complex termed the intraflagellar transport (IFT) complex that actively delivers axonemal building blocks such as tubulin from the base to the tip of growing cilia. Lack of cilia or its miss-construction leads to severe developmental diseases called ciliopathies. Despite its fundamental role in cilium biogenesis, the process of tubulin recruitment, loading and unloading by the IFT machinery remains poorly understood. In this proposal, I aim to elucidate the mechanism of tubulin loading onto IFT complexes by determining high-resolution structures of intraflagellar transport (IFT) complexes bound to tubulin. Details about the IFT-tubulin interaction interface will be obtained by a combination of biochemical techniques like site directed photo- and chemical crosslinking followed by mass-spectrometry analysis and the structural biology techniques X-ray crystallography and single particle cryo-electron microscopy (cryo-EM). Ultimately, this study will enrich our understanding of cilium biogenesis and homeostasis by providing the first insight at atomic resolution into cargo selection and loading onto IFT machinery.

Keywords: intraflagellar transport ift,cilium formation,tubulin interaction,microtubules,ift structure
Emotional and Social Intelligence Analysis Advanced Solution for Business Performance Improvement (WINNING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Emotional and social intelligence is critical for business productivity but it’s very difficult to assess without managers’ personal bias. Most of inter-personal interactions occur in meetings (35-50% working hours) but nobody can measure their effectiveness without interfering and interrupting, thus lowering their performance. As a result, companies frequently invest in the wrong talents, teams or customers, relying only on “intuition”. There are some tools for speech analysis but they are all focused on a single speaker. A huge amount of information beyond knowledge (emotional, relational, cultural, etc.) is produced during meetings but there is no way to analyse it. WINNINGMINDS is a conversation Artificial Intelligence analysis software which captures and analyses discussions and context in real time, under a SaaS model for three customer processes: - Talent assessment: Who is the fittest talent. - Management & leadership meetings: Team effectiveness. - Client/account management meetings: Client’s emotional loyalty. It identifies work competences and skills, interactions, attitudes, employee wellbeing, level of collective intelligence, how effective a team is working together and its readiness to succeed on a task. It provides Benchmark Reports to compare different performance of groups, topics, meeting formats, etc. Main benefits for users are: - Reduce mis-hiring costs (€257k/head failed). - More customer satisfaction and loyalty (5% = +25-95% profit). - Increase meeting productivity (20%). For our company, we expect: - Consolidate business (our core product). - International expansion (mostly EU and USA). - Develop our IP assets and contribution (increase company value).

Keywords: emotional intelligence,business productivity,interactions,meetings,neuroscience,artificial intelligence,software,talent assessment,behavior analysis,management,reports
Advanced sensor-based design and development of wearable prosthetic socket for amputees (SocketSense)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Iceland,Spain,Germany,Greece,Sweden,Sweden,United Kingdom,United Kingdom
Call: Flexible and Wearable Electronics (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 3898591.25
EU funding (EUR): 3898591.25
Participants: 11
Project status: SIGNED

Limb amputations cause serious physical disabilities that compromise the quality of life of many people around the globe. There are 40 million amputees in the world with an estimated 2.4 million in the EU and approximately 215,000 amputation surgeries performed each year (around 90% are lower limb amputees). Thus, there is a growing demand for efficient prosthetic socket systems due to growing number of amputees and lack of an existing solution for the comfortable socket. This project aims to develop a new solution for a prosthetic socket by developing wearable sensors to be embedded in a socket for the amputee patients to wear in everyday life. The sensors will allow real-time data collection allowing prosthetist to monitor the evolution of the performance of existing socket as well as the anatomical changes of the residual limb of amputees. New algorithms will be developed to evaluate all the biomechanical characteristics so that once the existing socket does not serve the patient, a new socket will be produced automatically without the need for the patient to go to a clinic in advance. SocketSense will meet this healthcare need by means of sensors, biomechanical modeling, AI, unified software and additive manufacturing technologies. The sensors will be developed based on QTSS materials (patent protected under WO2017103592A1). Biomechanical analytical models will be developed to turn the sensor data into optimized socket design. The whole SocketSense technique and procedure will be validated through clinical trials. The proposed solution will help address the societal challenge of personalized health and care solution for the population of lower-limb amputees. The project will implement flexible and wearable electronics into new QTSS material fabricating lightweight, flexible, printed and multi-functional electronic sensors to be embedded in prosthetic socket system. The development in the project will address market demand worth €1.76 billion by 2021.

Keywords: sensors,printed electronics,biomechanics,socket,prosthetics,amputees
Optoelectronic medicine - nerve cell regulation with light (OPTEL-MED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Czechia
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1493198.0
EU funding (EUR): 1493198.0
Participants: 1
Project status: SIGNED

Bioelectronic medicine today is growing in leaps and bounds, with ambitious new technologies entering the clinic and already changing the lives of more than a million patients worldwide. Materials scientists are called to craft biomedical devices that are smaller, smarter, and less invasive. We propose to create implantable photovoltaic devices which can wirelessly stimulate the nervous system and enable a new type of minimally invasive optoelectronic medicine. To achieve this, we will use biocompatible organic semiconductors which can efficiently absorb light in the near infrared part of the spectrum, where biological tissues are transparent. By micropatterning stimulation pixels on ultrathin conformable substrates, we will create optoelectronic nerve cuff electrodes which will be orders-of-magnitude thinner than what is used clinically today. We will explore deeply the physics of this new type of electrolytic photovoltaic stimulator. The designs will be optimized to operate with safe light intensities delivered from outside of the body. Benchmarking the targeting of precise optoelectronic stimulation will be done in ex vivo and in vivo nerve models. Via control of spatial patterning and localized light actuation, we will develop unique understanding of highly specific and nuanced neural control. The unique aspect of precise neuromodulation wirelessly positions us to explore a number of fundamental questions in applied neuroscience. The project is driven by answering milestone scientific questions in device physics, photoelectrochemistry, and electrophysiology, however the project is simultaneously designed to tackle an important clinical application: vagus nerve stimulation (VNS). We will apply our findings to implement an implantable stimulator actuated transcutaneously by portable light sources. We will develop standard operating procedures for chronic optoelectronic VNS in rodent animal models, paving the way for future clinical trials.

Keywords: bioelectronics,neuromodulation,neural engineering,cellular photostimulation,organic electronics
Role of the Maternal Gut Microbiota in Immune Activation at the Maternal-Foetal Interface: Impact on Preeclampsia and Offspring's Immune Development (DaPhNIs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-07-16
End date: 2021-07-15
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Preeclampsia is a leading cause of morbidity and mortality in pregnancy. Although the pathogenesis remains largely elusive, it is thought to reside in loss of immune-tolerance at the maternal-foetal interface. At present, preeclampsia can neither be reliably predicted nor prevented. Scope of this research project is to investigate how changes in microbiota during pregnancy impact immune responses at the maternal-foetal interface, and to determine the consequences on pregnancy outcomes as well as development of offspring’s immunity. Translational relevance of findings specifically to preeclampsia will be evaluated in a large cohort of patients, with implications potentially arising from the identification of novel biomarkers and of molecular mechanisms amenable to pharmacologic intervention. The Experienced Researcher (ER) of this study, Dr. Silvia Giugliano, is an accomplished immunologist with primary expertise in organ-specific immune responses to microbes. Formerly an independent academic researcher in the USA, she was recently recruited to work at the European Institute of Oncology (Milan, Italy) by Prof. Maria Rescigno, a world-class expert in the field of microbiota and mucosal immunity, specifically to advance the hosting laboratory’s expertise in placental immunity. There is an urgent call for actions aimed at improving women’s health, and it is incumbent on the scientific community to tackle this issue. Thus, the present proposal captures the current zeitgeist and social responsibility of Science. Complementary, prime expertise between the ER and host laboratory will create a synergistic enterprise, ideally suited to the pursuit of this ambitious research goal. Findings and hypotheses generated in this process will kick off additional, related projects, and will be disseminated beyond the boundaries of the scientific community and to public audiences. The ER will emerge with new skills, and the capability to transition to independence in her home country.

Keywords: dysbiosis,b cell,placenta,microchimerism,noenatal sepsis,biomarker,metagenomic
Modulation of RNA-based regulatory processes by viruses (RegulRNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2021-04-30
Duration (months): 64.0
Total project cost (EUR): 1998291.0
EU funding (EUR): 1998291.0
Participants: 1
Project status: CLOSED

Small and large non-coding RNAs are essential components at the heart of gene expression regulation. The past fifteen years have witnessed the emergence of a new field of research impacting diverse domains of biology. Among these, virology is no exception and discoveries such as the antiviral role of RNA silencing, virus-encoded microRNAs (miRNAs), or miRNA-based regulation of viruses have notably shifted our views of host-virus interactions. Although we know a lot about the mechanisms of action of ncRNAs, and their role in the context of viral infections, we know much less regarding the control of the regulatory RNAs themselves. In other words, how are the regulators regulated? To provide answers to this burning question, we propose to use different viruses as models to investigate the various levels where modulation of regulatory RNA can occur. Thus, we will study the importance of RNA secondary and tertiary structure as well as accessory proteins in the regulation of miRNA primary transcript processing. In a second axis, we propose to investigate how the functional, mature miRNAs can be controlled. To this end, we will focus on the mechanisms of target-mediated miRNA decay and the role of competing endogenous RNAs. We will finally turn to the regulation of antiviral RNA silencing. Although it seems that this kind of defence mechanism exist in mammalian cells, it is not yet clear how physiologically relevant it is and how it interfaces with other innate immune mechanisms. In this multidisciplinary project, we will use a combination of techniques ranging from bioinformatics to cellular biology to achieve our goal to get a comprehensive view of how RNA silencing processes are regulated during virus infection.

Keywords: microrna,lncrna,rna regulation,mcmv,kshv
Active packaging for extending lifespan of champignon (CHAMPIPACK)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Thanks to CHAMPIPACK project, NEW PACK TECHNOLOGIES aims to irrupt in the European food packaging market with a new active container able to remarkably extend the champignon shelf life while its organoleptic properties are maintained. Driven by the goals of the European commission and Food and Agriculture organization of the united nations (FAO) related to reduction of food waste, raising awareness of consumers regarding healthy diets with fresh foods, and also due to the harsh competition in the food packaging sector, manufacturers of food packaging have begun to look for alternative able to accomplish the demands of the different actors in the sector. In this sense, champignon preservation has emerged as a challenge in the food packaging industry due to the high transpiration rates of mushrooms which provokes a quick condensation inside container. This humidity favors bacteria proliferation and therefore, champignon spoilage. The CHAMPIPACK packaging has already proved its suitability to overcome this challenge adding new advantages for the whole supply chain such as: assure a total protection from impacts, favor storage and shipping and enable reclosing the packaging to keep its preservative properties for the end user. Our preliminary projections of the market deployment of CHAMPIPACK in 2023 show a Return on Investment, ROI, of 2.55 for the first five years, impliying revenues of € 6 million for our company.

Keywords: active packaging,champignon,shelf life,humidity control
Coding for Interactive Communication and the Power of Adaptivity (Interactive)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: SIGNED

Error correcting codes allow for reliable transmission of data over unreliable channels. The 70 years of development that went into the study of error correction, following Shannon's ground-breaking paper in 1948, yielded a fairly complete theory with far reaching applications to other theoretical and practical fields. However, many modern communication settings are not simply about transmitting information, but rather operate over many rounds of interactive communication between different parties. Cloud computing, cryptographic protocols, and distributed computing schemes are prime examples of such settings. Due to the overwhelming success of classical error correcting codes, and because interaction is central in many applications, we strongly believe that the theory of interactive error correcting codes will be transformative. Crafting error correcting codes tailored for interactive settings, as well as understanding their fundamental limitations, is the main goal of this proposal. We will study some of the most exciting fundamental open problems in interactive communication. In particular, this includes computing the rate distance trade-off for interactive coding, and building error resilient schemes for distributed computing. We will consider a diverse set of ``classical'' questions in the interactive setting, as well as aspects of interactive coding that are unique and have no counterparts in classical coding. Further, we will build adaptive coding schemes which will achieve better rates than non-adaptive counterparts. Indeed, one of the main powers of interactive communication, and an integral part of this proposal, is adaptivity. Here, each party can adapt its actions based on previous communication. As our research draws ideas from several scientific communities, it will lift our understanding of interdisciplinary connections between them to new heights.

Keywords: error correcting codes,interactive communication