Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Controlled subradiance in atomic arrays (CORSAIR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1497378.0
EU funding (EUR): 1497378.0
Participants: 1
Project status: SIGNED

In the CORSAIR project, I propose to study and control subradiance, namely the suppression of collective spontaneous emission, in sub-wavelength arrays of two-level atoms, using a new atomic physics platform. Understanding and controlling how an ensemble of quantum emitters collectively emits or absorbs light is vital in several areas of science and technology. However, the description of this problem is a challenge since it amounts to a dissipative quantum many-body problem. This is why I propose to develop a new experimental research direction towards the following specific objectives: (i) The building of an experimental platform able to create ordered 1D and 2D arrays of atoms with sub-wavelength spacing, and high-fidelity detection of excitations in the arrays. (ii) The selective excitation of subradiant excitations, i.e., where collective spontaneous emission is strongly suppressed. I will develop an addressing scheme to populate a subradiant state with high fidelity and perform experiments demonstrating tailored light storage and retrieval, and metrological enhancement by subradiance. (iii) The understanding of how atomic correlations can be dissipatively engineered via subradiance. I will strive to observe the fermionic correlations that are predicted to emerge from collective decay in arrays, and I will map the phase diagram of a driven two-level atomic array. These objectives will be reached by developing dedicated new tools. I will use dysprosium, an atomic species with properties that allow novel cooling and trapping schemes that I propose to use. In the rich spectrum of Dy, I will isolate a two-level system with a narrow linewidth. I will further develop a novel addressing tool, that allows to drive an array with an alternating phase profile which directly excites a subradiant excitation. I will rely on a broad transition to perform time- and position-resolved high-fidelity measurements of excitations and correlations in the two-level arrays.

Keywords: atom light interactions,subradiance,dissipative many body systems
Liquid phase Ultrafast photoeMIssion spEctroscopy of nonadiabatic photoREactions in biomimetic systems (LUMIERE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,France,United Kingdom,Italy,Sweden,Czechia
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 2396628.0
EU funding (EUR): 2396628.0
Participants: 17
Project status: SIGNED

The chromophores of photo-responsive proteins (PRPs) are increasingly exploited in science and technology from time and spatially resolved studies of neural signaling to the engineering of fully synthetic molecular devices. This justifies the increasing need for interdisciplinary studies aiming at controlling the chromophore function and achieving novel applications. In this doctoral network we will combine design, preparation and theory of PRP chromophores operating as rotary molecular-level devices with the novel tool of time-resolved photoemission spectroscopy (TRPES) to unravel basic principles of their rotary function. The most prominent PRPs, e.g. retinal proteins, the green fluorescent protein or xanthopsin all convert the photon energy into rotary motion by leveraging efficient ultrafast double-bond isomerizations. There is a consensus that such energy conversion is mediated by conical intersections (CIs) between ground and excited state potential energy surfaces. TRPES is a novel method, emerging at the interface of ultrafast physics and chemistry, capable of imaging the dynamics through CIs, thus providing a unique view on the photon-to-nuclear-rotation transduction process. More specifically, novel TRPES tools developed within the network will be employed to study devices based on oxindoles and oxipyrroles, mimicking the green-fluorescent protein chromophores, and on cinnamic ester derivatives, mimicking the chromophores of xanthopsins. We will investigate and learn to control these systems studying selected sets of chemical substitutions and environmental effects. The development of an effective research protocol focused on the combination of novel syntheses, TRPES and interpretative state-ofthe-art quantum chemical methods, will provide a cutting-edge interdisciplinary training arena for talented doctoral students and will be complemented by a modern soft-skill learning program and intense knowledge exchange between science and industry.

Keywords: conical intersections,molecular switches and motors,photoemission spectroscopy,time resoved,bio mimetic
Implementing Primaquine Single Low Dose in Africa (IMPRIMA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: France,United Kingdom,Burkina Faso,Madagascar,Netherlands,Burundi
Call: Promoting implementation of research results into policy and practice (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-04-01
End date: 2027-03-31
Duration (months): 48.0
Total project cost (EUR): 3969906.25
EU funding (EUR): 3967406.25
Participants: 7
Project status: SIGNED

The 2021 World Malaria Report estimates that the number of clinical cases in 2020 was 241 million and the number of deaths was 627,000, an increase of 69,000 compared to 2019, a timely reminder to maintain good malaria control and introduce novel elimination strategies. In 2012, to further reduce malaria transmission and possibly reach elimination, the WHO recommended adding single low dose primaquine (SLDPQ) to artemisinin based treatments (ACTs) in low transmission settings and more recently in areas where artemisinin resistance is emerging. SLDPQ kills mature gametocytes, blocking the transmission between humans and mosquitoes and should see a reduction in the malaria burden with widespread deployment. Compounding the poor uptake of SLDPQ is the lack of child-friendly formulations of primaquine and lingering anxieties regarding primaquine-related acute haemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. Building on the good progress of the ‘Developing Paediatric Primaquine’ EDCTP2-funded project, aiming at prequalifying paediatric formulations, we have conceived the IMPRIMA project to support the adoption of SLDPQ by conducting a real-life implementation study using our flavoured primaquine for children. Key to our success is the unique triangle of interconnecting activities - clinical, community/sociological, and policy - all within a matrix of capacity building and strong coordination by all seven partners. Our ambitious proposal aims to demonstrate the safety, acceptability, and community benefit of SLDPQ in 3 African countries with different malaria epidemiologies. Engagement with the communities and policy makers are fundamental to effect a positive change in drug policy and contribute to malaria elimination. In parallel, capacity will be enhanced for conducting clinical trials and monitoring the evolution of antimalarial drugs resistance. We believe the IMPRIMA project fits extremely well with the priorities of this call.

Keywords: malaria,primaquine,africa,implementation,transmission blocking
Satellite Construction kit for Highly Unified Modular Assembly in Newspace applicatioNs (SCHUMANN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,Finland,Portugal
Call: Future space ecosystems: on-orbit operations, new system concepts (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2023-01-01
End date: 2025-04-30
Duration (months): 28.0
Total project cost (EUR): 1999868.75
EU funding (EUR): 1999868.5
Participants: 5
Project status: SIGNED

This proposal addresses sub-topic 1: R&I on new scalable satellite platform concepts and building blocks increasing the degree of satellite modularisation. SCHUMANN ambitions to strengthen the foundations of the future space ecosystem, by means of 2 complementary developments: (1) a Functional Spacecraft Module (FSM) consisting of a Refuelable Tank (RTa), along with a refueling experiment setup to support the testing and qualification of this module. This FSM will demonstrate that a “side”, standalone module development, by following appropriate design rules and leveraging previous OG developments, can be integrated at a late stage into an IOD mission. (2) a “Design and Development Specification for the Spacecraft Construction Kit” (DSSCK) consisting of a specification and tools aimed at guiding and supporting FSM developers, to make their modules compatible and usable in a single ecosystem.

Keywords: osam,oos,modularity,satellite,spacecraft,refuel,building block,ecosystem,newspace,interface
Food web control of the global topsoil carbon cycling (CARBONWEB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1861949.5
EU funding (EUR): 1861949.5
Participants: 1
Project status: SIGNED

Soil food webs process 90% of the terrestrial primary production and regulate the second largest carbon pool on Earth – soil organic matter. Soil food webs themselves are regulated by soil animals through changes in microbial functioning, detritus quality, and physical soil structure. However, neither drivers of soil food web structure and functions nor their effects on global biogeochemistry and carbon stabilisation are quantified across large environmental gradients. CARBONWEB addresses this challenge at the global scale and tests the following Key Hypotheses: (A) biotic controls of soil food web structure and functions increase under conditions promoting biological activity and nutrient limitation; (B) consumption of detritus by consumers in soil food webs increases the stable fraction of soil carbon across ecosystem types; (C) the effect of soil animals on multiple ecosystem functions increases with temperature, precipitation, and nutrient limitation, proportionally to the total energy flux in soil food webs; (D) the global net effect of soil animals on topsoil carbon is positive (>10% increase) and will increase with climate warming. To test my hypotheses, I will use (1) the first comprehensive global monitoring of soil animal communities in the framework of Soil BON, (2) an EU-wide survey and isotopic experiments on carbon stabilisation, (3) steady-state and dynamic food web modelling and AI-based animal image analysis approaches, and (4) geospatial extrapolations. My experience in soil macroecology, functional ecology, large-scale project coordination, and the established collaborative network will help to ensure this project is successful. I will describe and mechanistically model the status and trends of energy fluxes, animal biodiversity, and carbon pools in global topsoils. Results of the project will provide the first-ever global estimation of soil food web effects on soil functioning and facilitate long-term monitoring of soil biodiversity.

Keywords: food webs,soil biodiversity,energy flux,stable isotope,macroecology,decomposition,carbon sequestration
UPright radiotherapy: Learning, Innovation, Fellowship and Training (UPLIFT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Switzerland,United Kingdom,Belgium,Italy,France,Sweden,Slovenia,Poland,Czechia
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 4390537.37
EU funding (EUR): 3928528.8
Participants: 23
Project status: SIGNED

Radiotherapy (RT) is a mainstay of modern cancer treatment. Conventionally, RT is delivered to the patient lying on a treatment couch, while a beam steering device (gantry) aims the radiation from any angle around the target. Positioning the patients in upright body posture (upRT) instead enables to orient the patient arbitrarily toward a fixed beam. This enables smaller facility footprint and reduced treatment cost, placing upRT in the core of the UN sustainable development goals, and opening global access to advanced treatment options: 80% of cancer patients live in countries which host only 5% of the world’s RT resources. Moreover, upRT improves patient comfort and is associated with anatomical and physiological advantages, such as reduced breathing motion. It therefore comes as no surprise that, with new upright patient positioning & imaging solutions entering the market, upRT is enjoying a surge in interest. Yet, key scientific questions remain, international guidelines for upRT are lacking, and existing RT workflows are geared to lying patients. As the first clinics adopt new upRT technologies, there is a global need for trained professionals in industry, clinics and academia, to reach the promised benefits for patient care. UPLIFT builds this next generation of experts by addressing key research questions related to: treatment planning, clinical workflow and equipment design. Leveraging latest upRT technology available through our world-class consortium, UPLIFT propels Europe to the forefront of the upRT paradigm shift. UPLIFT focuses on: Learning (through its academic and clinical centres of excellence); Innovation (through its leading industrial partners); Fellowship & Training (through an outstanding cross-sector programme of workshops, secondments & mentoring). Input from patient advocacy groups and an internationally renowned advisory board will maximise its impact. UPLIFT will revolutionize modern RT, making it more human, accessible and sustainable.

Keywords: upright body positioning
Detecting and Countering Information Suppression from A Transnational Perspective (DE-CONSPIRATOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Türkiye,Italy,Latvia,Netherlands,Belgium,Germany,Lithuania,Bulgaria,Spain,Georgia
Call: Developing a better understanding of information suppression by state authorities as an example of foreign information manipulation and interference (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2999766.25
EU funding (EUR): 2999766.25
Participants: 14
Project status: SIGNED

The proposed project explores; a) how Russia and China pursue information-suppression tactics in the EU and its partner countries (PCs) and how they construct/strategize these tactics, b) which cases of FIMI have been the most impactful in EU countries and PCs, and how to measure the importance of future FIMI 'attacks' c) which transnational dissemination and consumption networks have been contributing to the success of foreign information-suppression attempts within the EU, d) the social and psychological drivers of which forms of FIMI succeed, e) how can the existing legal, regulatory, and diplomatic frameworks in the EU (such as the GDPR or Digital Services Act) and PCs be improved to build greater resilience against such efforts, and f) opportunities and pitfalls of platform-level governance that could be improved to improve collective EU and PC defences against FIMI, in an interdisciplinary, multi-method, interconnected and multinational manner. The value of this research linkage is; (1) better understanding FIMI from the perpetrator side for more accurate defense, (2) why trans-European information networks knowingly or unknowingly (misinformation vs disinformation) adopt semantic narratives of certain FIMI attempts and contribute to their domestic and Europe-wide dissemination, (3) synoptically evaluate and methodologically sharpen existing research on cognitive and societal drivers of which topic and content types remain most salient in ‘successful’ FIMI cases, (4) approach the research gaps that exist in this field by providing an interdisciplinary focus by combining political communication, international relations, social psychology, area studies (EU, China and Russia), security studies and computational social science, and (5) present an expanded solution space by creating an interconnected menu of legal, regulatory, diplomatic and technological policy and regulatory options to help counter FIMI in a more coordinated and targeted fashion.

Keywords: disinformation,information suppression,foreign information manipulation and interference
Spectral Interpretability for Molecular Potentials Learning with Graph Neural Networks (SIMPL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

The SIMPL project (Spectral Interpretability for Molecular Interaction PotentiaLs) is designed to enhance the interpretability and efficiency of Graph Neural Networks (GNNs) used to model Molecular Interaction Potentials (MIPs). GNNs have greatly advanced the prediction of molecular interactions, which is crucial for fields like drug discovery and material science. However, the complexity of these models often makes it challenging to identify which molecular interactions are most critical, limiting their practical application. SIMPL addresses this challenge by incorporating Spectral Graph Theory and Algebraic Topology into GNNs, allowing for clearer interpretation and streamlined models, focusing on the most relevant interactions without sacrificing accuracy. Compared to traditional gradient-based methods, which can be unstable and sensitive to specific molecular conformations, SIMPL offers a robust approach. Instead of a localized insights that could vary significantly depending on the particular state of the molecule or be subject to vanishing or exploding gradients problems (especially in complex models), SIMPL provides a global perspective by assessing the relevance of interactions across the entire learning task. This ensure that the identified interactions are consistently important and reliable. This approach in practice forces a multi-body expansion of the MIP leading to a comprehensive understanding of molecular systems. While SIMPL has broad applications, it will be applied to the study of immune recognition processes, such as peptide-Major Histocompatibility Complex (MHC) binding. The framework’s ability to reliably identify critical molecular interactions could significantly enhance our understanding of these processes, leading to more informed approaches in immunotherapy and vaccine development.

Keywords: molecular interaction potentials,simplicial complexes,spectral graph theory,explainable ai,immune recognition
High Resolution Laser Spectroscopy of Atomic Hydrogen and Deuterium (H-SPECTR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Discrepancies between theory and experiments have been fueling the development of physics. Today, Quantum Electrodynamics (QED) is the most accurate theory and served as a blueprint for all subsequent field theories. Physics beyond the Standard Model must exist as we know from observations of the cosmos. It is likely to be found where no one has looked before, i.e., at very large energies, high sensitivity, or high precision. To progress with the so-called precision frontier, high resolution spectroscopy of atomic hydrogen and hydrogen-like systems continues to play a decisive role because their simplicity. Testing QED means to verify the consistency of parameters that enter this theory as they are obtained from as many different measurements as possible. Spectroscopic data also provides the input for the determination of the best values for the fundamental constants. The largest leverage for the determination of the Rydberg constant is currently due to the 1S-3S transition frequency that we want to improve in the framework of this proposal. A second apparatus provides a cold metastable 2S beam of atomic hydrogen and deuterium. This will be used in a series of measurements between the 2S and nP states as well as two-photon transitions between 2S and nS/nD states (with n=3…10). The same apparatus can be used to remeasure the 1S-2S transition frequency as an improved result from anti-hydrogen is expected. The work with the spectrometers builds on proven technologies. To go further we are proposing a method to trap atomic hydrogen in an optical dipole trap that operates at the magic wavelength. The proposed scheme avoids a cooling laser and will not be more complex than existing optical lattice clocks. It could eliminate all leading systematics for the above-mentioned transitions. Moreover, it could be employed as a computable clock to redefine the SI by fixing the value of the Rydberg constant. The new SI system would then be based exclusively on defined constants.

Keywords: fundamental physics,precision measurements