Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Federated artificial intelligence for privacy-preserving international stratification of colorectal cancer patients (Microb-AI-ome)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Romania,Austria,France
Call: Computational models for new patient stratification strategies (HORIZON-HLTH-2022-TOOL-12-two-stage, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 5996818.75
EU funding (EUR): 5996818.75
Participants: 8
Project status: SIGNED

In the EU, 1 in 35 women and 1 in 23 men will be diagnosed with colorectal cancer (CRC) in their life span (ca. 340,000 cases and 156,000 deaths in 2020) causing an annual economic burden of ca. 20 billion EUR. Identifying CRC early enables better treatment options. Screening usually entails a quantitative faecal immunological test (FIT) to predict the need of colonoscopy for the detection of colorectal lesions, an expensive and invasive procedure. We aim to predict this need with specificity increased by >20 percentage points by using metagenomic microbiomes. We hypothesise that computational microbiome profiles extracted using artificial intelligence (Al) technology will allow for optimised personal therapy stratification. However, clinicians do not have access to broad microbiome data. With Microb-AI-ome, we will develop a novel kind of computational stratification technology to enable microbiome-enhanced precision medicine of CRC. Metagenomic microbiome data to date is distributed over many national registries, and privacy regulations are hindering its effective integration. With Microb-AI-ome, we will overcome this barrier by establishing the first privacy-preserving federated big data network in CRC research. We will integrate isolated, national databases into one international federated database network - rather than a cloud - covering metagenomes for over 5,000 individuals screened for CRC, and an expected total of 100,000 by 2026. Microb-AI-ome ensures that no sensitive patient data will leave the safe harbours of the local databases while still allowing for the classification of clinical CRC phenotypes, which we will demonstrate in clinical practice allowing regulatory bodies to adopt evidence-based guidelines. Our consortium combines expertise in CRC and its treatment, microbiomics, artificial intelligence, software development, and privacy protection to close the gap between privacy and big data in international medical research.

Keywords: privacy by design,federated database network,colorectal cancer,microbiomes
Knowledge Transfer for Widened EU Excellence in Advanced Green Technologies, Sustainability and Research Management (WIDEX)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Slovakia,Spain,Greece,Germany,France,Finland,Poland
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1606518.2
EU funding (EUR): 1492271.6
Participants: 11
Project status: SIGNED

Critical minerals and elements are highly significant for Europe's economy, particularly within strategic sectors. However, the demand for new, often essential materials conflicts with the decreasing activity in primary raw material mining. As a result, there is an impending need to fulfil these demands within European borders, reducing reliance on third countries. This was recently reflected in the European Raw Materials Act as a clear necessity from the EU, being a potential solution the use of green and non-invasive technologies to recover and refine CRMs. Besides this, it is known that the reserves and productions of mineral resources in Slovakia are mainly located in Kosice region (46% Slovak geological reserves), thereby, enhanced networking and positioning activities between TUKE and the top-class leading research institutions are needed in order to close the still apparent research and innovation gap within the EU. Furthermore, TUKE is a distinguished mining university and serves as the primary reference centre within Slovakia, which will be boosted and reinforced in three main strategy lines through several learning tools and materials. These will be focused on: 1) exploration, recovery and mining monitoring exploitation, 2) capacity to drive sustainability, circularity and social assessment 3) Strengthening TUKE’s research management & coordination capacities, and administrative skills. The WIDEX implementation will include the creation of a new cluster in Central Europe, an excellent Virtual Centre, as well as a Stakeholder platform around the green and non-invasive technologies ecosystem, and a WIDEX’s WHITEBOOK based on the lessons learned.

Keywords: critical raw materials,circular economy,sustainable mining,resource efficiency
Spatiotemporal control of singlet oxygen release from supramolecular hydrogels to improve cancer therapy (OTHOx)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

This research aims to develop novel supramolecular hydrogels and study their application as singlet oxygen (1O2) carriers. In medicine, 1O2 generated in-vivo through photochemistry has been used to treat a variety of ailments including bacterial infections, acne, and several types of cancer. Though promising, this approach suffers from drawbacks such as diminished effectiveness in hypoxic conditions, both native and induced and lack of control over the total concentration and dosage of active 1O2. Recently, endoperoxides (EPO) have been identified as a potential solution for those, as they are self-contained sources of 1O2 produced ex-situ. However, they still do not allow for precise spatiotemporal control of 1O2 release, which is desirable to maximize for effectiveness of the treatment. Grafting EPOs on solid supports has been explored as a solution, but the state-of-the-art materials rely on complicated supports with low EPO loadings and thermal release mechanisms. Herein, we propose a new strategy for spatiotemporal control of 1O2 through the unprecedented use of hydrogels as EPO carriers. Hydrogels offer an easy to control and stable, but not persistent matrix in which the main component is water. The OTHO (oxotriphenylhexanoate) hydrogels enjoy unparalleled modularity, due to their highly robust and selective multicomponent one-pot synthesis. Thus, we will synthesize a range of OTHOs containing EPO units and perform detailed studies by rheology, solid-state NMR, small-angle x-ray and neutron scattering and electron microscopy to understand the properties and behavior of the resulting hydrogels. The biocompatibility and cytotoxic profile of the materials will be investigated against yeast cells expressing human disease markers. This will pave the way for a new breed of supramolecular pharmacology materials for 1O2 therapy against cancer.

Keywords: endoperoxides,singlet oxygen carriers,supramolecular gels,singlet oxygen therapy
High voltage, room temperature single-ion polymer electrolyte for safer all solid state lithium metal batteries (PSIONIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: France,Germany,Slovenia,Italy,Sweden,Belgium
Call: Advanced high-performance Generation 4a, 4b (solid-state) Li-ion batteries supporting electro mobility and other applications (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 7999741.26
EU funding (EUR): 7999741.25
Participants: 16
Project status: SIGNED

The greatest challenges towards the worldwide success of battery-powered electric vehicles revolve around the safety, energy density, and cost of the battery technologies. Solid-state polymer electrolytes and lithium metal anode address these challenges by replacing the flammable and unstable liquid electrolytes and enabling dendrite-free cycling of high-energy lithium metal cells manufactured by sustainable and cost-effective processing. The PSIONIC project advances the development of all-solid-state battery technology by employing amorphous cross-linked Polyethylene oxide (PEO) laminated on the thin lithium foil at the anode and high voltage cathode coated with a single-ion conductive polymer. This will allow to replace the flammable and unstable liquid electrolytes and enabling dendrite-free cycling of high-energy lithium metal cells manufactured by sustainable processing. Special attention will be devoted to the optimization of interfaces between the active material and polymer electrolyte. Materials selection will enable the use of the manufacturing technology available at BlueSolutions, which is readily scalable, based on sustainable processing using solvent-free extrusion. PSIONIC is aiming to develop cells with a safety hazard level 2, since no liquid component will be in the cell at the end of the project. The research and innovation actions carried under the PSIONIC project will not only just contribute to the technological advancements of all-solid-state Li-ion batteries in terms of safety, reliability, performance, cost, and sustainability, but will also enable higher uptake by the electromobility sector and end consumers, paving a pathway towards climate neutrality, and green energy transition.

Keywords: single ion conductive polymer all solid state battery sustainable processing
Arrhythmogenesis in Dilated Cardiomyopathy: Role of Mechano-Electric Coupling (RhythMEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 265647.84
EU funding (EUR): 265647.84
Participants: 3
Project status: CLOSED

Heart failure is a major cause of death in the Western world, with an estimated prevalence of 2-3\% of the population. A subgroup of heart failure patients is characterised by dilated cardiomyopathy (DCM) which results in substantial morbidity and mortality due to progressive mechanical pump failure (70\%) or sudden cardiac death from ill-predictable electrical disturbances (30\%). DCM is commonly linked to mutations encoding cytoskeletal proteins, but our understanding of why a loss of cardiac myocyte cytoskeletal integrity in inherited DCM phenotypes results in detrimental changes to calcium handling, and how this causes arrhythmias and sudden cardiac death, remains limited. Human studies have associated genetic mutations and loss in the cytoskeletal protein filamin C (FLNC) with arrhythmogenic DCM and sudden death. To explore the biomechanical and mechano-electric mechanisms by which FLNC deficiency leads to mechanical and electrical dysfunction, I will use experimental and mathematical models that span multiple spatial and temporal scales from the protein level up to the whole heart. I hypothesise that FLNC regulates myofilament lattice spacing and that loss of this structure leads to impaired contractile force development by the sarcomere. I postulate that these perturbations in mechanics may contribute to the generation of substrate for the induction and maintenance of lethal ventricular arrhythmias via a variety of mechano-electric coupling mechanisms. Particularly, stretch-induced alterations may affect cardiomyocyte electrophysiology, which may contribute to both the trigger and the substrate for arrhythmias. Thus, altered myocardial mechanics in the FLNC-null mouse model of DCM may contribute to the triggering or maintenance of life-threatening reentrant ventricular arrhythmias via a variety of mechano-electric coupling mechanisms.

Keywords: ilated cardiomyopathy heart failure mechanics electric coupling multiscale modelling murine models electro mechanics computational modelling
Gaseous detectors for neutrino physics at the European Spallation Source (GanESS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-02-01
End date: 2028-01-31
Duration (months): 72.0
Total project cost (EUR): 1496205.0
EU funding (EUR): 1496205.0
Participants: 1
Project status: SIGNED

The recent detection of the coherent elastic neutrino-nucleus scattering (CEnNS) opens the possi- bility of using neutrinos to explore physics beyond the Standard Model deploying small detectors. However, the CEnNS process generates signals at the few keV level, requiring very sensitive detection technologies. The European Spallation Source (ESS) has been identified as an optimal source of low energy neutrinos offering an opportunity to explore at depth the physics of CEnNS, with large discovery potential. In this project, I propose to apply the high-pressure noble gas TPC technology to the detection of the CEnNS process at the ESS. This will require the detection techniques sensitive to very low-energy depositions as well as improving the current knowledge of the quenching factor for nuclear recoils in xenon, argon and neon gas at keV energies. This project proposes the development of a novel detector able to hold 20 kg of xenon gas at high pressure. The device will operate at the ESS, providing more than 7,000 CEnNS events per year, potentially overtaking the sensitivities of much larger detectors in current spallation sources. Operation with xenon will explore most of the possible new physics associated with the CEnNS process. Furthermore, the high pressure technology offers the possibility to operate the same detector with different gases at minimal extra costs, thus providing a unique tool to further explore any signatures of new physics at the ESS.

Keywords: neutrino,gas detectors,coherent scattering
Innovative Integrated Tools and Technologies to Protect and Treat Drinking Water from Disinfection Byproducts (DBPs) (H2OforAll)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Portugal,Germany,Spain,Netherlands,Belgium,Israel,Sweden,United Kingdom,Cyprus,Poland
Call: Securing drinking water quality by protecting water sources against pollution, providing innovative monitoring and treatment solutions and ensuring safe distribution (HORIZON-CL6-2022-ZEROPOLLUTION-01, 2022)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 3452701.44
EU funding (EUR): 3452700.5
Participants: 18
Project status: SIGNED

Water purification and disinfection are crucial processes to provide safe water to citizens, but the low quality of water sources due to soil/freshwater increasing contamination makes this goal very challenging. Disinfection byproducts (DBPs), produced when chlorine disinfectant reacts with organic matter in water, have a serious impact even at low concentrations on the environment and human health, still not well understood. Effects on human’s liver activity and neurotoxicity were already reported. H2OforAll project aims to assess main DBPs sources and fate through the development of fast, cost-effective and accurate sensor monitoring devices and also by modelling their spread through drinking water distribution systems. In addition, DBPs toxicity and environmental impact will be studied in this project and measures will be proposed to protect drinking water chain. On the other hand, breakthrough water treatments to remove DBPs or avoid their formation during water disinfection processes will be developed, paying attention to their life cycle analysis, costs and risks. A central knowledge base with reliable data on the occurrence of DBPs in Europe and their effects will be created to increase awareness of society and governmental organizations about these drinking water contaminants in order to draw new policy responses and guidance.

Keywords: novel disinfection processes citizens engagement prevention measures risk assessment
Temporal dependence of enhancer function (TimedEnhancer)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

During vertebrate development, genes are regulated by distal regulatory elements, presumably via physical contacts between enhancers and transcription start sites. Alterations in enhancer sequences and/or their interactions with gene promoters can perturb gene expression, leading to developmental disorders and cancers, which argues for their pivotal role in transcription. Conversely, enhancer-promoter contacts can also be uncoupled from gene activation during developmental transitions and in single cells, where they are highly heterogeneous. Thus, the relationship between enhancer-promoter interactions and transcription is frequently indirect and the mechanisms that dictate when promoter-enhancer contacts can result in gene expression differences remain unknown. The core hypothesis of this proposal is that it is the timing of promoter-enhancer communication that instructs gene activation. Aim1 will examine whether and how the precise timing of enhancer-promoter interactions contributes to transcription. My group will determine which molecular mechanisms during transcriptional activation are regulated by enhancers contacting their target genes at different time points during embryonic stem cell differentiation. Aim2 will investigate how present and preceding enhancer-promoter contacts relate to transcriptional activity and transcription factor binding in single cells. My group will develop a genomic approach to trace the memory of preceding interactions at gene regulatory elements, thus adding a novel temporal dimension to current single-cell methods. By longitudinally combining cutting-edge genomic, single-cell and activity perturbation assays, my group will uncover how genes integrate regulatory inputs from several enhancers and assess how the timing of genome folding mechanistically contributes to this process. This research plan will newly elucidate temporality as a powerful feature that shapes the regulatory potential of enhancers and promoters.

Keywords: enhancers,3d genome structure,mechanisms of gene regulation,timing
Cultural Heritage Outreach in RomAnce Languages (CHORAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France,Italy,Romania,Portugal
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 4233600.0
EU funding (EUR): 4233600.0
Participants: 8
Project status: SIGNED

The Cultural Heritage Outreach in RomAnce Languages programme (CHORAL) is naturally linked to the enlarged European Alliance University UNITA, that brings together the universities of Turin and Brescia (Italy), Savoie Mont Blanc and Pau et Pays de l’Adour (France), Beira Interior (Portugal), Timisoara and Transilvania Brasov (Romania), Navarra and Zaragoza (Spain). These universities i have a strong track record of participating in international networks, joint research programs, educational and innovation projects. They also share a strong common heritage linked to Romance languages speaking populations (French, Italian, Portuguese, Romanian, and Spanish). In this context, a dedicated Cultural Heritage Hub (CHH) has been created to establish a research network within the Alliance structuring its research ecosystem facing cultural related challenges. This Alliance aims to become a key player in the construction of the European Higher Education and Research Area by developing an integrated European University that combines education, research, and innovation, with a focus on research areas that are strategic for the economic development of their territories. The CHH hopes to raise awareness and find solutions to societal challenges that the European Union is currently facing in order to strengthen rural territories, empower cross-border mountain communities, and reduce inequalities between the core and its peripheries. In a context of current crisis, and as natural borders have always been used to unite or divide communities, the challenges facing European Cultural Heritage are numerous so that a common training has become crucial. CHORAL doctoral programme will allow to progress in building a real community and sharing knowledge within UNITA CHH. This will be achieved by consolidating joint training and research activities and by putting together senior researchers, doctoral candidates and research managers around Cultural Heritage and Europe's cultural identity.

Keywords: study and preservation of tangible cultural heritage,intangible cultural heritage and identity narratives,dissemination of cultural and natural heritage,innovation policies for marginalised areas