Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
STRONG THERAPEUTIC OPPORTUNITY TO PROTECT FROM CHRONIC KIDNEY DISEASE (STOP-CKD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2450000.0
EU funding (EUR): 2450000.0
Participants: 1
Project status: SIGNED

ENYO Pharma is a late-stage clinical-stage biopharmaceutical company founded in 2014. Its mission is to develop innovative renal therapies to treat patients with kidney failure to prevent end-stage renal disease, dialysis and kidney transplantation. Among renal indications, chronic kidney disease (CKD) is recognized as a global public health problem because it affects 850 million people worldwide and will become the fifth cause of death by 2040. There is no cure for CKD. The current treatments mainly consist of marketed drugs dedicated to other indications (anti-hypertensives, diuretics, anti-diabetics drugs) with limited outcomes. To address the critical problem of these underserved CKD patients, ENYO Pharma is currently developing a pipeline of drugs with unique curative potential that is expected to fundamentally change the management of CKD indications. From a small synthetic molecule, Vonafexor, the company has created a family of molecules with several analogues exhibiting new and unique properties. Based on robust data obtained with Vonafexor in nine completed Phase 1/2 clinical studies in over 300 subjects, ENYO Pharma is focused on the development of its innovative new once-daily oral medication, Vonafexor-Lys. Vonafexor-Lys is the company value driver. The STOP-CKD project “Strong Therapeutic Opportunity To Protect From Chronic Kidney Disease” will accelerate the clinical validation of Vonafexor-Lys in a leading European nephrology center. By the end of 2025, we will have achieved the industrialization of the drug product and carried out three decisive renal clinical studies in Europe. This will enable product registration by 2029-2030. The EIC accelerator will be a fantastic booster for Vonafexor's pipeline for major kidney diseases. This will also support ENYO Pharma to continue its development in other critical diseases related to kidney impairment.

Keywords: kidney renal disease renal impairment creatinine glomerular filtration rate phase 2 clinical study liver and kidney crosstalk renal interstitial fibrosis renal inflammation dialysis
Kinesthetic Displays: Creating Embodied Experiences of Movement Using Vibrotactile Feedback (KinestheticDisplays)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1492798.0
EU funding (EUR): 1492798.0
Participants: 1
Project status: SIGNED

Kinesthesia – awareness of position and movement of body parts – is essential in all aspects of life. Kinesthesia enables mundane activities such as typing or lifting a glass to our lips, as well as feats like playing a piano concert or competing in an elite sport. It not only provides information about our body, but also helps form an embodied understanding of the world around us. Although kinesthesia is central to human experience, it is barely used in human-computer interaction (HCI). However, existing methods like visual retargeting or auditory body illusions suggest that such displays are possible. Vibration, exemplified by the Pinocchio Illusion, might be an ideal actuation method to convey kinesthetic information; however, the literature shows no systematic way to achieve this. I aim to design kinesthetic displays (KDs), general purpose devices that provide an embodied experience of movement. I will apply a sensorimotor perspective to the design of vibrotactile feedback, building on my know-how of using sensorimotor contingencies for designing vibrotactile material experiences. In this project my team and I will design a series of prototype KDs which will be used to study how design decisions, stimulation parameters, and algorithms influence the introspective experience of movement. The resulting data will be used to formulate design guidelines for KDs and to establish an empirical theory of sensorimotor interaction. KDs will transform remote and co-located training and skill sharing. KDs will help us better understand our own bodies and provide amputees with sensory access to prosthetic limbs or other body augmentations. Finally, KDs will provide digital systems with an embodied channel of communication, revolutionizing how we interact with computers.

Keywords: haptics,embodied interaction,kinesthetic experiences,body based user interfaces
HYbrid hydrogels based on 2D materials and conducting polymers for piezoresistive SENSing (HYSENS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Hypertension and cardiovascular diseases remain major global health challenges, yet current blood pressure (BP) monitors are bulky and provide only intermittent readings. The HYSENS project seeks to revolutionize wearable BP monitoring by developing advanced piezoresistive sensors based on hybrid hydrogels. Our innovative hydrogels integrate functional 2D nanomaterials (e.g., MoS2) and conductive polymers (e.g., polyaniline) into a biocompatible matrix, achieving high sensitivity, excellent durability, and a linear response within the physiological pressure range. HYSENS targets two key exploitable results: a battery-free NFC-based sensor for on-demand measurements and a LoRa-enabled device for continuous, remote monitoring. The NFC system capitalizes on energy harvesting from NFC interrogation, minimizing motion artifacts by capturing controlled, brief readings. In contrast, the LoRa-based device employs adaptive signal processing and power management strategies to ensure accurate, real-time monitoring even during patient movement. Extensive research will optimize hydrogel synthesis, nanomaterial anchoring, and electrical calibration, while rigorous biocompatibility and stability tests will ensure safe, long-term use on the skin. By bridging lab-scale innovation and real-world application, HYSENS offers a scalable, eco-friendly, and cost-effective solution that promises to transform personalized healthcare and reduce the burden of cardiovascular diseases. Collaboration with industry partners such as Dropper Srl and STMicroelectronics will further support commercialization through strategic regulatory and market pathways.
AUTOMATION TOWARDS MULTIMODAL TRANSPORTATION AND INTEGRATION OF FREIGHT (AUTOMOTIF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Italy,Germany,Ireland,France,Belgium,Switzerland
Call: Operational automation to support multimodal freight transport (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 3918937.5
EU funding (EUR): 3918937.5
Participants: 19
Project status: SIGNED

AutoMoTIF will focus on the development of strategies, business and governance models, regulatory recommendations and synergies that will enable the integration and interoperability of automated transport systems and solutions towards the operational automation of multimodal cargo flows and logistics supply chains in the intra-European network. It will list the gaps – both regulatory and technological – that are currently identified in automated transport technologies and logistics operations between modes and hubs through the analysis of automation demand and supply in multimodal transportation (users vs market). AutoMoTIF will follow an inclusive model to ensure that user and community needs are properly addressed and innovations are aligned with their expectations. UCs and scenarios will focus on real challenges and gaps in seamless automated logistics that will be simulated in real settings and different geographical locations. The results of the UCs will be used to set up a master scenario addressing the end-to-end delivery of goods using highest degree of automation possible. The outcomes from current practices will be analysed, leading to the assessment of benefits that can be gained by exploiting automated transport means to seamless multimodal automatic cargo transport and vice versa. These benefits will be defined and analysed based on their social, environmental and economic impact, such as decreased emissions and congestion, improved working conditions and safety, as well as reduced logistics and freight transport costs, with the SSH aspects being a priority. AutoMoTIF will contribute to the enhancement of synergies among sectors and stakeholders, following European priorities, strategic partnerships, such as CCAM, Zero Emission Waterborne Transport and EU Rail JU to ensure that transferability of expected outcomes.

Keywords: multimodal freight transport seamless automation
New markets: Structural analysis and Mechanism design, with applications to airport capacity problems (APCAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1494008.0
EU funding (EUR): 1494008.0
Participants: 1
Project status: SIGNED

Our economy relies on auctions to efficiently allocate scarce resources, and we use auction models to understand competition in bidding markets. However, traditional auction analysis is limited to existing mechanisms as it relies on bid data to estimate firms' latent values. Instead, APCAP proposes to study the welfare effects of implementing auctions in new markets. Auction values are characterized based on the profits generated from auctioned items and can be estimated using appropriate demand and supply models, bridging two disconnected strands of research in Industrial Organization. This idea is used to study various angles of the pressing airport capacity problem and how to best allocate scarce airport slots to competing airlines. New structural models and estimation techniques are developed to capture the complexities of this issue, made possible by unique access to highly detailed datasets. - Project 1 considers the endogenous formation of a product network with spillovers in costs and demand (to quantify how airlines respond to shocks) and shows how to estimate such a model when entry barriers constrain the observed network. The model estimates highlight the role of capacity constraints in network formation and help understand the competitive pressure of low-cost carriers in slot auctions. - Project 2 captures the differential impacts of extending vs. optimizing existing airport capacity while endogenizing the intensive margin of delays, flight cancellations, and emissions. An estimation strategy is developed to estimate demand when observing only aggregate prices. - Project 3 estimates the magnitude and drivers of slot synergies and uses computer science techniques to assess the welfare impacts of large-scale slot auctions. - A transversal project leverages these methods and data to provide insight into the understudied European airline industry, as well as how auction impacts vary depending on the market structure and (demand) factors local to an airport.

Keywords: airline industry,empirical auction analysis,demand and supply,entry models,combinatorial auctions,airport slots,mechanism design,structural estimation
Framework for coordination of Automated Mobility in Europe (FAME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Belgium,Austria,Germany,Greece,Spain,Sweden,Netherlands,France,Finland,United Kingdom,Czechia,Hungary
Call: Framework for better coordination of large-scale demonstration pilots in Europe and EU-wide knowledge base (CCAM Partnership) (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-07-01
End date: 2025-06-30
Duration (months): 36.0
Total project cost (EUR): 5682500.0
EU funding (EUR): 5682500.0
Participants: 23
Project status: SIGNED

FAME will develop and validate common methodologies and tools to facilitate the sharing of best practices and lessons learned to support the collaboration within the community of CCAM stakeholders across the complex cross-sectorial value chain needed for the organisation and evaluation of large-scale demonstration and future scale-up to the impacts of complete CCAM solutions. The mission of FAME supports the commitment of the European Commission and the CCAM Partnership to provide a long-term coordination framework for R&I and large-scale testing and evaluation activities in Europe. The establishment of a stakeholder-validated European framework for testing on public roads, including a CCAM test data space (TDS), a common evaluation methodology (CEM), and of means for exchange of knowledge on CCAM activities will improve cooperation, consensus building and data sharing. It will enable comparability and complementarity of the results of all testing and large-scale demonstration activities in Europe. FAME builds on a strong legacy of EU-funded Coordination and Support Actions which have developed harmonised methodologies and federated large networks of stakeholders to drive consensus building on challenges, needs and requirements for CCAM and Field Operational Tests. FAME involves 23 partners and over 2000 subscribers of the current Joint CAD network which has collaborated with the European Partnership on CCAM Partnership since its inception. The development of the European Framework for testing on public roads is at the core of FAME. The overall approach is built around three main building blocks and aims to engage with and enable (in terms of capacity building) stakeholders from the CCAM area, as well as capitalise knowledge about CCAM through an integrated approach including stakeholder engagement (WP3), research and innovation on the evaluation methodology and testing framework (WP 4 and 5) and communication and knowledge sharing (WPs 1 and 2) to maximise impact.
Strengthening global cooperation and institutional capacities in sub-Saharan Africa to facilitate implementation of the GH EDCTP3 programme (EDCTP Africa Office)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Coordination and support actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Netherlands
Call: HORIZON-JU-GH-EDCTP3-2022-OA1 Grant to identified beneficiary - Support for an Africa office (HORIZON-JU-EDCTP3-2022-GH-Africa-IBA, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 3691250.0
EU funding (EUR): 2953000.0
Participants: 1
Project status: SIGNED

This proposal is in response to the GH EDCTP3 call for support to EDCTP Africa Office (AO), which is part of the EDCTP Association Secretariat, based in Cape Town and hosted by the South African Medical Research Council. The aim of the proposal is to provide support for the operation of the AO to ensure optimal implementation and visibility of the GH EDCTP3 programme in SSA. The AO will provide technical support, promote networking activities (South-North, South–South), ensure alignment of the funded activities, strategic partnerships, and increase visibility of the GH EDCTP3. This aim of the project will be achieved through several activities that include technical support for the design, implementation and monitoring of capacity developing activities, monitoring funded projects, organising workshops, and facilitating dialogue between African and European research entities and stakeholders. The expected impact is a strengthened and improved delivery of the GH EDCTP3 programme in SSA. The implementation of this proposed project will be structured into four work packages (WP) called Project management (WP1), Capacity development and networking (WP2), Strategic Partnerships (WP3) and Conferences, forums, and meetings (WP4). Through this grant the AO will contribute to the following impacts: Accelerated product development for fighting target infectious diseases; Facilitated preparedness against public health emergencies in line with One Health; Increased visibility of AU-EU partnership in science; Ensured close alignment with SSA national research programmes and activities on target diseases and R&I; Increased participation of SSA countries in GH EDCTP3; and Increased participation of industry and private entities in product development and clinical trials in SSA. To implement the project fully the AO will need a competent Project Coordinator, four Project Officers, a Senior Administrative Officer and an Office Manager. The project will be 2,953,000 euros.

Keywords: edctp africa office gh edctp3 support
Controlling Cavitation for the Activation of Small Molecules (ConCASM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499643.0
EU funding (EUR): 1499643.0
Participants: 1
Project status: SIGNED

Sonochemistry is the use of ultrasound to facilitate chemical reactions. Chemical reactions requiring stringent conditions can be effectively carried out using sonochemistry at ambient conditions. The current state of sonochemistry is limited by the low efficiencies in converting electrical energy to cavitation energy for free radical generation. This makes the application of ultrasound for chemical synthesis an expensive technique in terms of energy per productivity. Controlling cavitation with novel catalytic cavitation agents (CCA) to reduce energy requirement for inertial cavitation will open a new paradigm for sonochemistry, potentially impacting the catalytic chemistry, acoustic and sonochemistry communities and opening opportunities to address challenges faced by chemists in sustainable chemicals synthesis. The objective of my project is to systematically progress towards deep understanding of cavitation bubbles generation through in-situ observation approaches, engineering of multifunctional catalytic cavitation agents and machine learning. This will exert better control on the formation, uniformity and collapse location of cavitation bubbles thereby significantly reducing acoustic energy requirement for inertial cavitation. I will synthesize multifunctional transition metal oxides catalytic cavitation agents, investigate and optimize their structure/properties relationships in response to acoustic cavitation. This project offers a unique integration of approaches, competences and resources in material science (synthesis of CCAs), physics (modelling) and chemistry (activation of small molecules). The iterative project focus on the most fundamental understanding of the physical mechanisms, will allow for substantial progresses into the complex phenomenon of sonochemistry and sonocatalysis.

Keywords: sonochemistry,acoustic cavitation,heterogeneous nucleation,radicals,
Subliminal learning in the Mandarin lexicon (SUBLIMINAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2483750.0
EU funding (EUR): 2483750.0
Participants: 1
Project status: SIGNED

Central to this research project is the observation that there are regularitiesand systematicities in the spoken language that escape our awareness, that are shielded from us by linguistic traditions and cultural conventions embodied in writing systems, but that nevertheless are detected by our brains, albeit subliminally, and used to optimize lexical processing. Philosophers such as Emmanual Kant, Edmund Husserl, and Maurice Merleau-Ponty, and more recently the cognitive scientist Hoffman, have called attention to how our perception of reality is shaped by and filtered through our minds and bodies. According to Hoffman, mathematically, fitness beats truth: our perceptions of the world are tuned to our survival. Writing systems are culturally evolved technologies that also hide from our eyes and ears the truth about what we really hear and say. Obviously, in order to work, writing systems must abstract away from the full richness of the spoken word. However, many features of our speech that are masked by writing systems, are nevertheless exploited by our cognitive system when we listen or speak. For native speakers, mismatches between speech and writing are relatively unproblematic. For second language acquisition, however, mismatches can render learning unnecessarily difficult. The research programme for which I am requesting funding addresses this issue for Mandarin Chinese. Two kinds of mismatches will be investigated, using state-of-the-art methods in computational modeling, distributional semantics, and statistical analysis: subliminal mismatches between what written words are supposed to sound like, and how they are actually spoken, and subliminal mismatches between how the writing system is supposed to work, and how it actually functions and, as a semiotic system of its own, influences thought. These investigations will inform the applied goal of this project: developing ways to enhance vocabulary learning of Mandarin Chinese as a second language.

Keywords: phonetics,corpus linguistics,mental lexicon