Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrating Ecosystem Heterogeneity to Enhance ESM Performance (iEcoH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 196400.4
EU funding (EUR): 196400.4
Participants: 2
Project status: CLOSED

Earth system models (ESM) are widely used to predict future climate and inform policy (e.g. IPCC). Recent research suggests that ESM do a poor job predicting future climate because they exclude microbial biogeochemical cycling and soil heterogeneity (e.g. texture), which affect the climate system. As an ecosystem ecologist with a strong background in microbial drivers of biogeochemistry, my primary goal is to use data from a robust global study measuring the effect of climate change on ecosystem processes to enhance the next generation of ESM making them more accurate and relevant to global policy. To achieve this goal I have developed key collaborations. Dr. H. Lee is an expert ecological modeler with an interest in enhancing ESM. NorESM is a leading ESM developed in Norway and used in many international modelling programs e.g. IPCC. Dr. A. Classen manages a 10 site global network measuring the ecosystem level impacts of warming. Dr. W. Wieder has initiated the development of the Microbial Mineral Carbon Stabilization (MiMiCS) model, which considers microbial drivers and soil heterogeneity; however this module requires verification and integration into ESM. My objectives are to (1) Train at the with Dr. Lee and develop ESM simulations for our 10 sites, (2) Generate a field based dataset with the help of Dr. Classen and (3) Compare simulations and field data to verify and enhance MiMiCS and (4) Integrate the newly enhanced MiMiCS into NorESM. During this action I will enhance my career by becoming a key user of cutting-edge ESM, furthering international collaborations, and enhancing European based ESM. Moreover, I will transfer my knowledge of biogeochemistry and ecosystem ecology to model developers and scientists internationally with the goal of creating synergies. The end goal of this action is to ultimately improve our ability to model future climates bringing our predicted climate scenarios closer to reality in order to better inform key policy.
Restart of blocked replication fork at replication fork barrier (Rep. Fork Restart)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Errors in replication of DNA lead to serious diseases like cancer, inherited neurological and muscular diseases. Replication is constantly challenged by various obstacles that can result in error-prone replication. Replication fork barriers (RFBs) include proteins bound to DNA, structure forming sequences and DNA/RNA hybrids. Replication forks (RFs) stalled or blocked at these barriers can be rescued by a converging fork. But if this fails blocked RF must be restarted to complete replication. Restart using homologous recombination (HR) can lead to gross chromosomal rearrangements and copy number variations. The newly restarted replication fork is also prone to slippage leading to mutation and rearrangements. The research questions I will address are how this RF is restarted and why it is error prone. I will focus on restart at a site-specific RFB in fission yeast, RTS1. Restart at RTS1 has been well characterised in the host laboratory. My project will identify DNA structures formed during the RF restart and characterise recruitment of factors involved in the restart of the collapsed RF. The acquired data will enable us to further understand the mechanism of RF restart and to unravel the cause of the error prone nature of newly restarted RF. I consider this fellowship a key step in my career as it allows me to transit from the analysis of site-specific lesions in prokaryotes (previous doctoral fellowship) to eukaryotic cells, gain experience in a wide range of techniques (2D gels, Electron microscopy, ChIP) and build contacts with experts in the field of eukaryotic replication restart. This is necessary for my future independent research and will enable me to set up my lab to study molecular actors and DNA structures during bypass of single lesions in bacteria and eukaryotic cells. The mentoring during the fellowship will provide me with the necessary training to successfully establish myself as an independent investigator.

Keywords: replication fork barrier,stalled,blocked replication fork,replication stress,dna structures,mechanism of replication fork restart,structure of restarted replication fork
Male pregnancy – Unravelling the coevolution of parental investment and immune defence (MALEPREG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-02-29
Duration (months): 72.0
Total project cost (EUR): 1499989.0
EU funding (EUR): 644150.5
Participants: 2
Project status: SIGNED

The question of how sex roles and parental investment have evolved belongs to the most controversial unresolved issues in evolutionary biology. The costliest form of reproduction regarding parental investment is viviparity. Its independent evolution in most vertebrate groups has required drastic morphological and genomic reorganisations in the sex bearing the young. Yet our knowledge is heavily biased towards mammals, where changes in the immune system and microbial composition are associated with pregnancy and placentation. Which factors have caused the selection and accompanied evolution of viviparity in other vertebrates remains severely understudied. As the evolution of viviparity is a textbook model of convergent evolution, I plan on using a comparative approach to identify selection and fitness benefits leading to the evolution of viviparity. I propose analysing mating system evolution, focusing on the unique evolution of male pregnancy in sex-role reversed syngnathids (pipefishes and seahorses) that show a gradient from external fertilisation to full viviparity and are, thus, ideal to study the evolution of viviparity. Only this genus allows the role of egg production and viviparity to be disentangled, as both traits co-occur in the female in most other species. As immunological tolerance is fundamentally associated with the evolution of pregnancy, I will investigate how male pregnancy has coevolved with adaptive immune system rearrangements and the broodpouch specific microbiota. Comparative genomics, transcriptomics and genetic engineering utilizing CRISPR/Cas9 will elucidate the genetic basis of trait loss and gain required for male pregnancy. In particular, I will assess whether new functions arose via gene duplication and neo-functionalization, via gene co-option or via de novo gene emergence. This proposal will pave the way for studying viviparity evolution beyond the mammalian model and will provide a fresh look at sex roles and parental investment.

Keywords: sex roles,parental investment,viviparity,immune system,microbiota,convergent evolution,male pregnancy,teleosts,pipefish,immunological tolerance
Hydrogen Delivery Risk Assessment and Impurity Tolerance Evaluation (HYDRAITE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Germany,Norway,Sweden,Finland,France,United Kingdom
Call: Limiting the impact of contaminants originating from the hydrogen supply chain (H2020-JTI-FCH-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-09-30
Duration (months): 45.0
Total project cost (EUR): 3499867.5
EU funding (EUR): 3499867.5
Participants: 8
Project status: CLOSED

HYDRAITE project aims to solve the issue of hydrogen quality for transportation applications with the effort of partners from leading European research institutes and independent European automotive stack manufacturer, together with close contact and cooperation with the European FCH industry. In this project, the effects of contaminants, originating from the hydrogen supply chain, on the fuel cell systems in automotive applications are studied. As an outcome, recommendations for the current ISO 14687 standards will be formulated based on the technical data of the impurity concentrations at the HRS, FC contaminant studies under relevant automotive operation conditions, and inter-compared gas analysis. The methodology for determining the effect of contaminants in automotive PEMFC system operation will be developed by six leading European research institutes in co-operation with JRC and international partners. In addition, a methodology for in-line monitoring of hydrogen quality at the HRS, as well as sampling strategy and methodology for new impurities, gas, particles and liquids, will be evolved. Three European laboratories will be established, capable of measuring all of the contaminants according to ISO 14687 standards, and provide a strong evidence on the quality and reliability on their result. Beyond the project, the three laboratories will offer their services to the European FCH community. In addition, a network of expert laboratories will be set, able to provide qualitative analysis and the first analytical evidence on the presence or absence of these new compounds with potential negative effect to the FCEV. The efficient dissemination and communication improves the resulting data and input for the recommendations for ISO standards of hydrogen fuel. The project and its results will be public, to boost the impact of the project outcomes and to enhance the competitiveness of the European FC industry.

Keywords: pemfc,hydrogen quality,hydrogen quality assurance,hydrogen impurities,hydrogen sampling from hrs,automotive hydrogen fuel
Green and Diverse Cities. The social impact of urban policies for sustainability in comparative perspective. (GranD Cities)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

The need for more sustainable cities has been considered a key point of global strategy for the future and one of the most important aims of the EU strategy for the urban environment. However, sustainability can also be described as one piece of rhetoric; far from being an effective paradigm, being too broad, vague and economically-centred, and with no specific social dimensions clearly set out. Although the attention to social inclusion, especially in the most deprived urban areas, is an important pillar of urban sustainability, a clear evaluation of the social impacts of sustainability programs in EU Cities is still missing. This investigation aims to fill this gap, by analysing, in comparative perspective, the social impacts of green renewal and development in Europe. By selecting as case studies Vienna and Copenhagen, two cities that have been particularly successful in implementing policies of environmental sustainability, the research project aims to identify intended and unintended impacts of these strategies in terms of social and spatial inequality among social groups. The project will adopt the following research strategies: quantitative data gathering; interviews with key informants in cities; ethnographic research in areas of the cities affected by green urban renewal and programs for sustainability; comparative analysis of data and information. As far as the results expected for the ER by this period of training, they are primarily the following: to acquire specialized knowledge on Comparative Urban sociology; to consolidate the ER’s methodological skills in regards to mixed methods of analysis; to develop the ER’s multicultural communication skills by conducting empirical research in German; to publish two scientific articles and a volume with an international publisher. The MSCA fellowship will give her the opportunity to further consolidate her professional maturity in order to enter the EU academic job market with a tenure-track position.

Keywords: urban sustainability,urban political ecology,social inequalities,spatial inequalities,comparative urban sociology,environmental sociology
Engaging Urban Youth: Community, Citizenship, and Democracy (CMCG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

Disadvantaged youth in urban environments often experience marginalization and disenfranchisement that can lead to disastrous consequences for them, their families, and wider society. We know that successfully engaging these young men and women in the institutions, communities, and contexts in which they live and building their capacity as social actors can be a critical factor in their positive development as individuals and future role as citizens. Yet, there is still relatively little known empirically about the specific contexts, strategies, and mechanisms through which disadvantaged urban youth can be most effectively engaged. This research is designed to develop the expertise of the experienced researcher to enable him to contribute much needed in-depth knowledge of how best to engage young people as citizens both civic and political actors with autonomy and responsibility for contributing to the common good. This work will be done through a comparative case study in three Irish cities. The methodology will involve a consultative process with designated stakeholders in each city including local politicians, policy leaders, service providers, service users, youth representatives and youth workers. It will involve field observations and interviews with young men and women in three selected case study cities, each having a distinct urban identity: Large multi-cultural (Dublin); Post-Conflict ( Belfast) and Smaller Regional City (Galway). Dissemination and Public Engagement are central to this proposal. The research will impact on the participating stakeholders by providing tangible and accessible research findings. It will impact on the field of urban youth studies by offering a comparative framework applicable to other urban contexts in Europe and globally. The impact for the experienced researcher will be the development of specific expertise with a view to developing further European and global studies of this important field.

Keywords: urban youth citizenship ireland social exclusion participation democratization of young people comparative framework
The Creation of Tokens in Late Antiquity. Religious 'tolerance' and 'intolerance' in Fourth and Fifth Centuries AD (TOK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-07
End date: 2021-11-06
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

This innovative project aims to investigate the phenomenon of the production of late-antique tokens as objects embodying the relations between different religious identities in Roman society. In particular, the study focuses on the so-called “Vota Publica coinage” (or “Festival of Isis coinage”) and “Asina tokens”, both minted in the Roman West during the fourth century and perhaps the fifth century AD. These issues are still partly unpublished and furnish valuable data. Since the creation of these “pagan” objects took place during the gradual repression of polytheistic cults by a Christian government, the project will shed light on the question of religious freedom and on the dynamics of religious “propaganda” during an era that saw the transformation of the pagan Roman Empire into a Christian one. Unlike traditional approaches, religious politics will be examined through the innovative perspective supplied by the numismatic evidence of tokens, which, as an expression of relationships, exchanges and culture, contain a remarkable informative potential for the understanding of broader aspects within ancient communities. Through this lens, the project will focus on specific social, religious, and cultural experiences in the context of the “conflict” between pagans and Christians in the fourth and fifth centuries AD. The adoption of an interdisciplinary approach and the mobilization of intellectual tools forged by classical disciplines will help to formulate appropriate patterns and to develop an analytical inquiry on the psychological, social, religious and political changes and interactions revealed by tokens in the late Roman empire. This project will therefore make a historical contribution to current reflections on religious “tolerance” and “intolerance” that have a significant preponderance in societies past and present. Addressing a matter of continuing concern, the project will help inform contemporary debates in different fields of the scientific research

Keywords: tokens,coins,iconography,tolerance,intolerance,religious conflict,religious coexistence,propaganda
Implementation Action to prevent Diabetes from Bump 2 Baby (IMPACT DIABETES B2B): a low-resource system of care intervention for appropriate gestational weight gain and improved postnatal outcomes (IMPACT DIABETES B2B)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Spain,Australia,Ireland,Denmark,Denmark,United Kingdom,United Kingdom
Call: Implementation research for maternal and child health (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 4318747.5
EU funding (EUR): 3999949.0
Participants: 10
Project status: SIGNED

IMPACT DIABETES B2B will demonstrate the real-world implementation of an evidence-based, low-resource system-level intervention for healthy gestational weight gain and early prevention of maternal and child diabetes, overweight and obesity when delivered ‘at scale’ across antenatal settings. Gestational diabetes affects up to 18% of pregnancies worldwide and is an increasing health problem for both mothers and babies. By identifying those most at risk of developing gestational diabetes and working with them through personalised health coaching delivered via smartphone App, this project will engage, motivate and empower this target group to lead healthier lives for improved wellbeing and pregnancy outcomes. This project will demonstrate implementation within 3 European countries and Australia with clear line-of-sight on future scale-up across different contexts and resource settings via its innovative implementation toolkit and workshops for dissemination and exploitation. Pregnancy is a unique time in life with potential to influence maternal health, and the health of the next generation. IMPACT DIABETES B2B delivers breakthrough research in nutrition, exercise and behaviour change leading to an implementable low-resource system-level intervention. The personalised feedback will empower women to manage their health, delivering cost-effective management of excess gestational and post-pregnancy weight gain to: improve pregnancy and postpartum outcomes; improve utilisation of healthcare services; and encourage ongoing maternal health with sustainable impact for mother and family. Expertise in implementation science, lifestyle change, health psychology, mHealth technology, health economics and health service delivery will lead this mixed methods project. The project will co-design the intervention system, with end-user context and management explored throughout. The work will evaluate clinical, economic and implementation outcomes to inform future practice and policy.

Keywords: gestational diabetes,diabetes prevention,mhealth,mixed methods,behaviour change,obesity prevention,screening
Spectral synthesis of multidimensional supernova explosion models (SNSM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Core-collapse supernovae are the explosive deaths of massive stars. They are the main production sites of the heavy elements in the Universe, drive galactic dynamic and chemical evolution, and produce exotic remnants such as black holes and neutron stars. To interpret observations and advance our understanding of the origin of the elements, sophisticated spectral models are needed. The main science objective in this proposal is to compute the first spectral models of multi-dimensional core-collapse explosion simulations. These models will then be compared with available high-quality data to derive information on nucleosynthesis yields and supernova structure. The proposed work involves the development of spectral modelling tools from current 1D to multi-D capability, and application of these to recently computed state-of-the-art 3D explosion simulations. This innovative project will allow a milestone in supernova research to be reached by producing the first light curves and spectra of modern 3D simulations, and will approach us to solving an almost 50 year standing mystery of how supernovae explode and how the elements are produced.

Keywords: supernovae,radiative transfer,nucleosynthesis