Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Compositional Approximate Reasoning via Bialgebraic Semantics (CARBS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2020-01-31
Duration (months): 12.0
Total project cost (EUR): 91727.4
EU funding (EUR): 91727.4
Participants: 1
Project status: CLOSED

Programming languages with probabilistic features are used extensively in computer science and beyond, to model uncertainty, perform quantitative analysis, inference and much more. To analyse programs in such languages, it is essential to have effective tools and techniques for approximate reasoning: for instance, determining the chance of congestion in a network, or the chance of failure of a system component. CARBS proposes a general mathematical framework of compositional proof techniques for approximate reasoning, with two essential points of focus: general applicability, to deal with the wide variety of different quantitative languages and models, and compositionality, to deal with large-scale systems. A motivating case study and application for the developed proof techniques is ProbNetKAT, a probabilistic language for describing randomized protocols and analysing quantitative properties in networks such as throughput or chance of failure. Approximate reasoning about such network programs is an important but also challenging problem, and the abundance of possible case studies will allow to immediately evaluate and apply the developed proof techniques. Approximate reasoning requires to move from behavioural equivalence to behavioural metrics, formalising how far apart two programs are. CARBS is based on integrating behavioural metrics in bialgebraic semantics, a categorical approach for a systematic study of languages and calculi based on the combination of algebra and coalgebra. Coalgebra allows to define behavioural metrics, in a general manner, whereas algebra integrates compositionality in the associated proof techniques. The overall envisaged result of CARBS is an extension of bialgebraic semantics to quantitative systems, providing on the one hand fundamental insights about quantiative coalgebras and compositionality, and on the other hand concrete, effective proof techniques for approximate reasoning.

Keywords: coalgebra,bisimulation,behavioural metrics,quantitative systems,probabilistic systems
Global dynamics of mountain diversification and persistence (GAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Why does the geographic distribution of species richness vary so much across the earth’s surface? This question has been a central focus of biology for almost two centuries, but despite extensive study, biologists have been unable to provide a comprehensive answer. Considering global richness patterns, tropical mountain ranges stand out as the hotspots for vertebrate species diversity. However, our ability to predict the large number of species present in these areas as a result of current climatic and environmental conditions is poor, implying an important influence of evolutionary history in generating these trends. In GAP, I will test the relative importance of different evolutionary processes; dispersal, diversification and lineage persistence in generating species richness patterns throughout the world’s mountain regions, for the most speciose avian order (passerines, ~6,500/10,000 bird species). I will also test whether diversification, followed by the dispersal of lineages from mountain regions to lowland areas, is a major contributor to the production of continental/global gradients of species richness, evolutionary diversity and functional diversity. To determine where efforts should be focused to preserve montane diversity into the future, I will also evaluate how conservation threat status varies among global mountain assemblages, and how well this predicts the evolutionary and functional diversity maintained there. I will achieve these analytical objectives following the generation of a novel and comprehensive global dataset. This will encompass a time-calibrated phylogeny, classifications of global mountain regions and elevational zonation for the world’s passerine species. Together, the research outputs from GAP will significantly improve our understanding as to why mountains are so rich in species, and how historical processes in these areas have influenced the formation of global biodiversity gradients.

Keywords: species richness,mountains,dispersal,diversification,macroevolution,macroecology and passerine birds
FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA (FAIR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Switzerland,Switzerland,France,France,France,Netherlands,United Kingdom,United Kingdom,Denmark
Call: Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 10162903.75
EU funding (EUR): 10162903.75
Participants: 16
Project status: SIGNED

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance (AMR) and the curative failure. The FAIR consortium aims at assessing an adjunct to antibiotic therapy as an emerging concept of overcome AMR in pneumonia. The project leverages (i) a unique immunomodulatory flagellin that enhances airway epithelial innate immune defences and increases the therapeutic outcome relative to antibiotic alone, and (ii) airway-specific aerosol delivery by nebulization. FAIR’s objectives are to: • develop nebulization modalities for optimal airway targeting and rapid action at the infection site • demonstrate that nebulized flagellin strengthens the response to antibiotics in relevant preclinical models of antibiotic-resistant pneumonia • identify host immune factors required for the gain of protection with systems biology • implement pharmacokinetics/pharmacodynamics model-based design and simulation for clinical validation • assess nebulized flagellin’s safety in a Phase I clinical trial. • analyze the acceptability and economic relevance of the therapy • identify stratification markers that predict the course of pneumonia and treatment in antibiotic-treated cohorts. Expected outcomes include the enrichment of the pipeline of novel treatments against pneumonia, reinforcement of EU capacity to control AMR and infections, the Phase I safety report on nebulized flagellin, recommendations for future trials, and acceptability by the stakeholders and cost-effectiveness for public health. FAIR will develop new avenues of research on mechanisms of action of the adjunct flagellin, and will define (for future trials) the subpopulation of patients that might benefit most from this treatment. Our industrial partnerships and exploitation plan will enable straightforward development of drug and nebuliser device, and bring innovation to the patients.

Keywords: innate immunity,toll like receptor,nebulization,pneumonia,antimicrobial resistance,antibiotic,phase i clinical trial
Self-Emulsification Route to NanoEmulsions by Cooling of Industrially Relevant Compounds (CoolNanoDrop)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Bulgaria,United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 70000.0
Participants: 2
Project status: CLOSED

Industrial emulsification often requires inefficient, high energy processes, such as mechanical shear leading to high temperatures in emulsificaiton. Our new efficient method has enabled self-emulsificatino at low temperatures by simply cooling an emulsion. We will apply this method to industrially relevant compounds for the food and pharma industries.

Keywords: self emulsification,nanoemulsions,cooling,industrial emulsification
Digital Scores – investigating the technological transformation of the music score (DigiScore)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Australia,China,United States,United Kingdom,United Kingdom,Canada
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1999985.0
EU funding (EUR): 1150331.29
Participants: 6
Project status: SIGNED

Digital scores utilising computational technology and digital media are emerging worldwide as the next evolutionary stage in the concept of the music score (Vear 2019). Yet there has been no scientific study of digital scores; nor their effect upon creativity and musicianship. This is remarkable for two reasons: First, because digital scores are generating new music experiences, innovative compositional approaches, novel performance opportunities, and broader accessibility for a vast number of musicians and music cultures around the world. Second, because many topics immediately adjacent or informing digital scores have been theorised thereby liberating these subjects and innovating creative practices, e.g. digital media art, digital performance, electro-acoustic music. This project will launch the first scientific investigation into the transformation of the music score through computational technologies. The core aims of the project are to: (1) determine scientific knowledge of how digital scores stimulate new creative opportunities and experiences within a range of music practices, (2) develop a theoretical framework for digital scores as an important transdisciplinary area of research, (3) build a scientific study of inclusive digital musicianship through the transformative potential of the digital score. This project will investigate these questions through an innovative combination of artistic and scientific research methods, undertaken by a transdisciplinary and international team of scientists and artists, led by a world expert of digital scores: Prof. Dr. Craig Vear. This is real “frontier research”, the benefits of which extend beyond music studies into computer science, new media research, digital humanities, performance studies and creative practice.

Keywords: music scores,performance practice,computational technology
Understanding the balance between functional and deleterious interactions of alpha-synuclein with lipid bilayers (toxiclipasyn)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Proteins are among the most essential molecules of life. In order to fulfil their native function(s) they need to adopt a well-defined three-dimensional structure. However, under some circumstances, proteins can misfold and/or form toxic amyloid structures, which are the hallmark of a range of diseases including type 2 diabetes and neurodegenerative diseases. In particular, the small pre-synaptic protein, alpha-synuclein (AS), whose aggregation is the hallmark of Parkinson’s disease, can adopt in vivo and in vitro an intrinsically disordered conformation in solution and an alpha helical state when bound to membranes; the equilibrium between these two conformations has been shown to be important for its proposed native function, e.g. synaptic plasticity, and to modulate its kinetics of fibril formation. Here, I propose to investigate the physiological factors responsible for the switch between functional and deleterious interactions between membrane bilayers and AS due to ageing or disease using an innovative combination of biological, structural, thermodynamic and kinetic studies. In particular, I propose to use both synthetic lipid model systems and isolated synaptic vesicles to study the effect of ageing and the presence of lipids associated with Parkinson’s disease pathology on the nature of the interaction between AS and lipid bilayers. The synaptic vesicles will be isolated from the brain of mice at different ageing stages, as well as from mice carrying gene modifications or knock out related to PD. The interaction between AS and the vesicles will be studied using a range of biophysical techniques including circular dichroism, fluorescence and nuclear magnetic resonance spectroscopy, Atomic Force and Electron Microscopy. The aim of this study is to establish a thorough understanding of the interplay between changes in lipid composition and increased propensity of protein aggregation.

Keywords: alpha synuclein,kinetic analysis,amyloid,parkinson s disease,lipid peroxidation,cholesterol,synaptic vesicles,lipidomic
The Innovation, Dispersal and Use of Ceramics in NW Eurasia (INDUCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2023-02-28
Duration (months): 78.0
Total project cost (EUR): 3095008.73
EU funding (EUR): 1706078.29
Participants: 3
Project status: CLOSED

The origins, adoption and use of pottery vessels are among archaeology’s most compelling issues. Pottery vessels are no longer viewed in western archaeology as a material correlate of sedentary farming life in the Neolithic. Despite recognition of pottery vessels in hunter-gatherer contexts in some parts of northern Europe and the former Soviet Union, their impact on, and role in, hunter-gatherer lifeways has been regarded as peripheral to mainstream European prehistory. This proposal seeks to rebalance the evidence and the debate, placing the innovation, dispersal and use of pottery vessels among hunter-gatherers in NE Europe at the heart of the enquiry. Virtually nothing is known of the choices underlying the adoption of pottery vessels or the uses to which they were put. Similarly, there is little understanding of the environmental contexts that led to the emergence of pottery or the timing and dynamics of its apparent westward dispersal across NE Europe, nor its legacy following the introduction of food production. Addressing these lacunae is the motivation for this proposal. INDUCE will tackle these important challenges with an integrated approach to reconstructing the contextual life histories of over 2000 pottery vessels, enhancing chronological control of early pottery horizons through 600 14C dates, investigating the typology of several thousand vessels from across the study region, creating spatio-temporal models for the spread of different pottery traditions and documenting the impact of the introduction of farming on the use of vessels for resource utilisation. This new understanding of pottery manufacture, dispersal and use across NE Europe will inspire a fundamental re-evaluation of later hunter-gatherer prehistory and culminate in an alternative narrative for the ‘Neolithisation’ of Europe.

Keywords: hunter gatherers,pottery vessels,organic residues
Getting new insights into the radio-sensitization effects of nanoparticles in photon and charged particle therapy (NANOCANCER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-30
End date: 2019-10-29
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The use of high-atomic-number nanoparticles (NP) as tumour radio-sensitizers has been recently proposed as a breakthrough in radiotherapy (RT). Numerous biological studies have shown the enhanced effectiveness in tumor cell killing when NP were associated to photon RT and, more recently, to charged particle therapy. However, the mechanisms of action are not clear yet. In addition to the damage due to a possible local dose enhancement (physical effects), the interaction of NP with essential biological macromolecules could lead to changes in the cells (biochemical effects) leading to an amplified effect of the radiation. Within this framework, the main goal of the NANOCANCER project is to get deeper insights into the mechanisms underlying the amplification of radiation effects of NP. For this purpose, I will use a multidisciplinary strategy to evaluate both the biochemical and physical effects involved in these innovative nano-RT approaches. Vibrational spectroscopy (Fourier transform infrared, FTIR, microspectroscopy) will be employed for the first time to investigate the biochemical features in glioma cells combining two high-Z standard nanoparticles (Au and Gd) and charged particle beams. Physical effects will be also assessed by performing complementary Monte Carlo simulation of radiation transport, which will allow a realistic modelling of early biological damages induced by the radiation at the nanometre scale. This interdisciplinary proposal will be essential to better characterize the radio-sensitization effects of NP in glioma cells and, in addition, will bring light to the present charged particle therapy radiobiology, which seems to lead to substantially different tumour responses with respect to conventional RT at the cellular and molecular level. The knowledge of these biochemical features will help researchers to develop RT by taking full advantage of the underlying biology an enhance the therapeutic index of RT for diseases with poor prognosis.

Keywords: radiotherapy,charged particle therapy,nanoparticles,dose enhancement,fourier transform infrared ftir microspectroscopy,glioma cells
PROactive Safety for PEdestrians and CyclisTs (PROSPECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Hungary,Sweden,Belgium,Sweden,France,Netherlands,Netherlands,United Kingdom
Call: Traffic safety analysis and integrated approach towards the safety of Vulnerable Road Users (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-10-31
Duration (months): 42.0
Total project cost (EUR): 6931978.75
EU funding (EUR): 6931978.25
Participants: 19
Project status: CLOSED

The past decade has seen significant progress on active pedestrian safety, as a result of advances in video and radar technology. In the intelligent vehicle domain, this has recently culminated in the market introduction of first-generation active pedestrian safety systems, which can perform autonomous emergency braking (AEB-PED) in case of critical traffic situations. PROSPECT will significantly improve the effectiveness of active VRU safety systems compared to those currently on the market. This will be achieved in two complementary ways: (a) by expanded scope of VRU scenarios addressed and (b) by improved overall system performance (earlier and more robust detection of VRUs, proactive situation analysis, and fast actuators combined with new intervention strategies for collision avoidance). PROSPECT targets five key objectives: i. Better understanding of relevant VRU scenarios ii. Improved VRU sensing and situational analysis iii. Advanced HMI and vehicle control strategies iv. Four vehicle demonstrators, a mobile driving simulator and a realistic bicycle dummy demonstrator v. Testing in realistic traffic scenarios and user acceptance study The consortium includes the majority of European OEMs (Audi, BMW, DAIMLER, TME and Volvo Cars) currently offering AEB systems for VRU. They are keen to introduce the next generation systems into the market. BOSCH and CONTI will contribute with next generation components and intervention concepts. Video algorithms will be developed by UoA and DAIMLER. Driver interaction aspects (HMI) are considered by UoN and IFSTTAR. Euro NCAP test labs (IDIADA, BAST, TNO) will define and validate test procedures and propose standardization to Euro NCAP and UN-ECE. Accident research will be performed by Chalmers, VTI and BME, based on major in-depth accident databases (GIDAS and IGLAD) and complemented by East Europe data. The work will be done in cooperation with experts in Japan (JARI, NTSEL) and the US (VTTI, UMTRI, NHTSA).

Keywords: integrated safety,vru accident research,predictive vru safety,predictive driver acceptance,autonomous emergency braking and steering,vehicle demonstrators,realistic test and assessment methods