Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Boosting Circular Systemic Solutions through Virtual Regional Circular Economy Spaces (CSSBoost)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Innovation actions
Countries involved: Greece,Spain,Portugal,Cyprus,Germany,Italy,Belgium,United Kingdom
Call: Circular Cities and Regions Initiative (CCRI)’s circular systemic solutions (HORIZON-CL6-2023-CIRCBIO-02, 2023)
Start date: 2024-06-01
End date: 2027-11-30
Duration (months): 42.0
Total project cost (EUR): 11267312.5
EU funding (EUR): 9190318.75
Participants: 21
Project status: SIGNED

CSSBoost aims to overcome technological and non-technological CE barriers, minimise CSS application and operational risks and decisively stimulate and maximise the Circular Economy and Bioeconomy Transition in any EU city/region or group of regions. To pursue this, CSSBoost develops a novel CSS Application Framework that views a CSS as a composite living entity that operates and evolves within a CE/CSS Ecosystem and Market, an open (physical) space of city, regional or multi-regional scope, encompassing an area’s existing CE market, its value chains and its entire external environment, even extra-regional entities and markets. It also introduces the methodological concept of the CSSBoost Integrated Solution that involves the integration of one or more CSS within a digital environment, enhanced by tailored methodology and procedures. This physical system is virtualised, monitored, analysed and assessed by developing the key CSSBoost innovation, the Virtual Regional CE/CSS Ecosystem and Market (VCEM). CSSBoost designs a set of diverse Exemplary CSSs, both as transition tools and to validate and promote its ideas by applying and demonstrating them in five city, regional and interregional Pilot Cases. The exemplary CSSs respond to different challenges, barriers, needs and feasibilities across EU and target different product value chains, as delineated in the EU’s Circular Economy Action Plan (Water, Food, and Nutrients; Plastics; Batteries & Vehicles). CSSBoost develops both its innovations and pilots by applying a rigorous SotA co-creation environment and instruments and SSH methods and procedures. It also develops replication, organisational, business and exploitation plans for the uptake, replication and upscaling of its solutions, as well as education and training programs and social innovation actions.

Keywords: circular systemic solution,circular economy transition digitalisation digital twins knowledge graphs twin transition
Theoretical Investigation of Surface Phonon Polariton-Based Quantum Photonic Circuits (PhonologiQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

The primary goal of the PhonologiQ research program herein described is to produce a simple and clear set of analytical expressions that detail the dependence of the efficiency of a surface phonon polariton-based integrated quantum photonic circuit on the material and geometric parameters of its nanoscopic components. This research will focus on three primary areas of novelty: 1) incorporating radiation into models of interactions between phononic waveguides and quantum emitters and antennae, 2) describing the effects of material nonlocality and anisotropy on the fundamental performance limits of the circuit, and 3) investigating novel hybridization-mediated pathways through which the efficiency of nonlinear circuit elements like switches or light sources can be enhanced without losing energy to radiation. Upon successful completion of the program, the results will be a useful roadmap by which experimental researchers working to realize the next generation of quantum photonic information processing systems can formulate concrete design criteria. The planned speedup to Europe's development of cutting edge computing technologies falls within the stated goals of the Horizon 2021-2022 Work Program to strengthen the R&I capacity, output, and transfer within and between European research institutions.

Keywords: infrared optical resonances,surface phonon polaritons
Valorization of Agro-Industrial Waste through Fungi Fermentation supported by Digital Modeling (Zest)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Denmark,Germany,Latvia,Serbia,Spain
Call: Improve fermentation processes (including downstream purification) to final bio-based products (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 7503688.75
EU funding (EUR): 5931246.25
Participants: 12
Project status: SIGNED

The world's ever-growing population demands an increasing amount of protein, which cannot be sustainably met through traditional sources. Innovative approaches are key to procure high-quality protein both efficiently and sustainably. ZEST plans to harness technologies that can exert a global impact, by producing close to user, thus minimizing the carbon footprint associated with logistics from farm to table. Fungi-based protein presents a promising solution to this challenge, given its versatility in utilizing a variety of raw materials and its potential for global production. ZEST's strategy focuses on devising an enhanced fermentation production system capable of generating a diverse array of bio-based protein products. Our primary objectives include: 1) Developing an efficient, zero-waste automatic production system. 2) Designing a multipurpose bioreactor adaptable to substrates with varying viscosities and dry matter content. 3)Assessing the entire value chains to ascertain their economic viability, market potential, environmental impact, and sustainability of fungal-based products. With the advent of advanced technologies such as Artificial Intelligence (AI), we can embed process knowledge into control systems. This ensures accessibility across both geographical and educational barriers, thus equipping these solutions to deliver maximal impact on the climate crisis through their truly global applications. Our strategy incorporates an efficient, zero-waste automatic production system that integrates feedstock screening, fermentation condition monitoring and control, along with downstream processing control. We will employ a variety of agricultural waste streams as feedstock. Also, ZEST aims to assess a range of compounds for their potential applications across various industries. ZEST's approach is geared towards driving the state-of-art in protein production efficiency, yield, and quality, with broad applications in the burgeoning biobased industry worldwide.

Keywords: food ingredient,cosmetics,pet food ingredient,protein,mycoprotein,digital modelling,mycelia fermentation,cascading approach,valorisation
Fluid-Rock Interactions for Environmental Sustainability (FRIES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Molecular hydrogen has already been demonstrated to be a viable source of clean fuel that is carbon-free, with water as the only byproduct when combusted. However, traditional methods of hydrogen production such as steam reforming are energy intensive and not viable as a mechanism for addressing demand on a global scale. Recent studies have demonstrated the occurrence of substantial amounts of molecular hydrogen produced naturally by fluid-rock interactions such as serpentinization, at a depth of few kms to several tens of kms in the Earth's subsurface and if these reserves were to be exploited, they would alleviate at least a substantial fraction of the demand for carbon-free fuel globally. Through the proposed research, we aim to integrate petrographic and microstructural observations from a suite of representative rocks from the Isle of Skye Volcanic Complex and the Shetland Ophiolites in the United Kingdom, with reactive transport and microstructural models to determine if fluid-rock interactions that produce hydrogen in the subsurface can be engineered to occur at near-surface conditions. Additionally, rocks which produce hydrogen are compositionally similar to rocks that have been used to sequester carbon dioxide and our proposed research aims to conduct an in-depth investigation into the potential coupling of these processes, to determine if hydrogen production and carbon dioxide removal from the atmosphere can be engineered to run concurrently. Finally, we aim to assess any potential risks associated with hydrogen production from water-rock reactions, as these induce profound transformations in the physical properties (such as volume) of rocks, which may have the potential to generate natural disasters such as earthquakes. The results from our proposed project would have extremely important implications for the much-needed energy transition and demonstrate the viability of ongoing geological processes for generating carbon-free sources of fuel.

Keywords: natural hydrogen,fluid rock interactions,microstructure,induced seismicity,carbon dioxide sequestration
(C)ombinatorial (O)ptimisation for (V)ersatile Applications to (E)merging u(R)ban problems (COVER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Türkiye,Poland,Spain,Slovenia,Switzerland,South Africa
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 399542.86
EU funding (EUR): 395600.0
Participants: 15
Project status: SIGNED

In addressing urbanization and sustainable development challenges, this project proposes a collaborative effort to harness the power of combinatorial optimization methods and operations research. Focusing on graph theory applications such as graph coloring and domination, as well as broader optimization techniques like integer programming, our interdisciplinary team seeks to address urban problems across European and Third-Country partners. By integrating expertise from academia, local communities, and industry, we aim to develop tailored solutions that enhance quality of life while promoting sustainable development principles. The project's objectives include identifying local urban challenges, creating theoretical models for optimization, and implementing innovative solutions. Through workshops, trainings, and collaborative research, we will engage stakeholders to define and prioritize urban problems, laying the groundwork for practical applications of combinatorial optimization techniques. Key initiatives include exploring the “15-minute city” concept to improve accessibility and mobility, proposing optimization models for post-disaster management, optimizing the placement of semi-mobile clinics for healthcare accessibility, and developing solutions for public transport networks. The project's innovative program encompasses various activities, including problem definition, theoretical modeling, empirical research, and knowledge exchange. Through a structured work plan, we aim to foster collaboration, knowledge sharing, and capacity building among project partners. By leveraging the expertise and diversity of our international consortium, we seek to create sustainable solutions with lasting impacts on urban communities beyond the project duration. Overall, this project puts forward a concerted effort to bridge the gap between academic research and practical urban challenges, demonstrating the transformative potential of combinatorial optimization in urbanization.

Keywords: combinatorial optimization graph theory operations research
Cross-species Regulation of Action by Controllability: a Keystone of 5-HT signalling? (CRACK-5HT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1483738.75
EU funding (EUR): 1483738.75
Participants: 1
Project status: SIGNED

Knowing the causal structure of a system enables controlling this system to our benefit. In neuroscience, the brain is widely envisioned as a complex controller whose main role is to help the organism reach and maintain itself into the most desirable states of its environment. However, not all environments are equally controllable and changes in environmental controllability require a permanent adaptation of cognitive and motor processes. Controllability estimation may thus play a key role in the regulation of action in health and disease, but its cognitive and neurobiological underpinnings remain poorly understood. Here, I will leverage a computational framework that I have recently developed to investigate in detail the neural implementation and the downstream consequences of controllability estimation for adaptive and maladaptive behaviours, with a particular focus on the serotonin (5-HT) system. My goal is to demonstrate that 5HT neurons broadcast controllability prediction errors and mediate the behavioural effects of controllability estimation in rodents and humans performing homologous tasks. To do so, I will record and manipulate the activity of genetically defined 5-HT neurons using light-based techniques and pharmacological manipulations. I will further test whether drug-naïve patients diagnosed with depression suffer from downward biases in controllability estimation and whether these biases can be alleviated by the initiation of serotonergic antidepressants. Finally, I will probe the neural mechanisms underlying controllability estimation mechanisms in healthy and depressed participants using functional neuroimaging. The ambition of this translational project is to untangle the complexities of 5-HT signalling and clarify its roles in depression and antidepressant treatments, which are still elusive despite decades of research. As such, it may provide new insights and predictive phenotyping tools for evidence-based approaches in neuropsychiatry.

Keywords: serotonin controllability depression antidepressants calcium imaging optogenetics fmri translational research
Modernisation of Agriculture through more efficient and effective Agricultural Knowledge and Innovation Systems (modernAKIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Belgium,Bulgaria,Croatia,Finland,Greece,Hungary,Ireland,Italy,Latvia,Poland,Portugal,Romania,Slovakia,Spain,Slovenia,Lithuania,Czechia,Cyprus,Sweden,Luxembourg,Malta,Austria,France,Germany,Estonia,Netherlands,Denmark
Call: Improving national AKIS organisation in a co-creative process across the EU (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-09-01
End date: 2029-08-31
Duration (months): 84.0
Total project cost (EUR): 9999481.25
EU funding (EUR): 9999481.25
Participants: 39
Project status: SIGNED

modernAKIS aims to improve AKIS actors’ capacities to leverage individual, organizational and systemic resources needed for the transformation towards more coherent, effective and efficient AKIS systems and the transition to a more sustainable management and use of natural resources in farming and forestry. To this end it will build and foster a European network of at least 1.000 key AKIS actors, including AKIS coordination bodies, from all EU MS, who will act as linchpins in the transformation of the AKIS systems towards a more effective governance and the modernization of the European agri-food sector. The project will also build the capacities of these key AKIS actors towards systems understanding and engagement, enabling them to enact long-term system changes that will improve the AKIS. In addition, it will set up at least 1 Community of Practice in each Member State, enabling thus participants to act as vectors of change in their communities. In addition, modernAKIS will provide a comprehensive digital catalogue with new know-how, and at least 80 tools and methods supporting key AKIS actors to improve the knowledge flows and develop a well-functioning AKIS in line with relevant policy objectives, e.g the Green Deal, Farm2Fork, SDGs.

Keywords: agricultural knowledge and innovation systems,modernization of agriculture
X-Ray Fluorescence Imaging of Metal Complexes in Hypoxic Tumor Spheroids (ImageTumor)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,New Zealand
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: CLOSED

According to estimates from the World Health Organization (WHO) in 2019, cancer is the second leading cause of death after heart failure before the age of 70. The field of metal-based anticancer drugs has been on the rise ever since the discovery of the anticancer properties of cisplatin in 1965, which is in daily clinical use against various types of cancer. Many compounds failed to enter clinical studies since their anti cancer activity is mainly studied in two dimensional (2D) monolayer cells which does not mimic the complex tumor micro environment in humans. In the human body the cancer tumors grow in 3-dimensional structure, hence it is vital to study the anticancer activity of a drug molecules in the 3D tumors rather in 2D mono layer cells. Next, tumor hypoxia (1% Oxygen), a situation where tumor cells are deprived of oxygen, is a major challenge for oncology. In this project we propose the synthesis of N-Heterocyclic Carbene/1,8-naphthalicanhydride conjugated series of metal complexes (Gold, Rhodium, Iridium) to study the anticancer activity and penetration depths in 3D tumor spheroids under hypoxia. We also investigate the activation by reduction mechanism in presence of cellular thiols and cytotoxicity in vitro (3D cell spheroids) and compare the results among the three metal centers. The metal protein interactions play key role in many biological processes; hence we also investigate the metal-protein interaction studies using capillary electrophoresis inductively-coupled mass spectrometry (at secondment). We will investigate the structure activity relationship between metals and of related coordinating ligands in 3D spheroid under hypoxic conditions. We mainly utilize X-Ray Fluorescence (XRF) imaging and synchrotron radiation to test the cellular localizations and penetration depth for the proposed metal complexes. This project is expected to yield unique insights towards optimization of next-generation anti-tumor drugs.

Keywords: x ray fluorescence imaging,metal complexes,cytotoxicity,hypoxia,tumor spheroids,metal protein interactions,
Synthetic Data Generation Framework for Integrated Validation of Use Cases and AI Healthcare Applications (SYNTHIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Spain,Netherlands,Italy,Greece,Germany,Luxembourg,Belgium,Austria,Slovenia,Norway,United States,Hungary,France,Denmark,Switzerland,United Kingdom,India,Finland
Call: Maximising the potential of synthetic data generation in healthcare applications (HORIZON-JU-IHI-2023-05, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 22415540.25
EU funding (EUR): 12438775.0
Participants: 39
Project status: SIGNED

SYNTHIA is an ambitious collaboration between public and private institutions to facilitate the responsible use of Synthetic Data (SD) in healthcare applications. The project will improve the methodological and technical aspects of SD Generation (SDG) by developing new techniques and advancing established ones for different data modalities, including genomics and imaging, to improve the generation of realistic multimodal and longitudinal data. This project will provide the research community with approaches for transparent benchmarking of alternative SDG methods for specific applications, identify and establish evaluation metrics and methodologies, and contribute to the standardisation of an evaluation assessment framework for SD. Robust evidence of SD applicability in a set of use cases across a broad spectrum of medical conditions will be crucial to demonstrate the potential of SD to accelerate data-driven solutions of equivalent quality to those derived from real patient data. Furthermore, legal and regulatory implications of SD use will be analysed with the aim of delivering an assurance framework to guide secure SD utilization in healthcare. These significant breakthroughs will be implemented through the open SYNTHIA federated platform, facilitating responsible SD use by the health research community. The platform will facilitate users´ long-term access to extensively validated, reusable synthetic datasets, as well as to SDG workflows and SD assessment frameworks. The federated infrastructure will rely on extended open-source frameworks for interoperability with other data-sharing infrastructures in the context of the European Health Data Space. A multidisciplinary collaboration of SDG developers, FAIR data experts, clinical researchers, developers of therapies and data-based tools, legal experts, socio-economic analysts, regulatory, policy advocacy, and communication experts will provide a 360º vision on how to advance healthcare applications through SD use.

Keywords: synthetic data generation,sd publishing platform,federated infrastructure,patient data privacy protection,bias minimisation,quality assessment,clinical utility validation,elsi,regulatory impl