Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EU-CEPI Framework Agreement for vaccine development (ECFAVD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Framework Partnership Agreement
Countries involved: Norway
Call: Grant to the Coalition for Epidemic Preparedness Innovations (CEPI) (H2020-FPA-SC1-CEPI-2019, 2019)
Start date: 2019-04-16
End date: 2022-04-15
Duration (months): 36.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: SIGNED

This annex underlines the rationale of the added value of proposed framework program agreement (FPA) between CEPI and the Commission. CEPI was established in the wake of the Ebola outbreak following calls for action to establish global funding and facilitation mechanisms to be better prepared for the next outbreak of an emerging epidemic disease though the development of vaccines. The R&D Blueprint for Action to Prevent Epidemics developed by the WHO serves as CEPI’s point of departure for selecting priority diseases as it works towards a world in which epidemics are no longer a threat to humanity. CEPI does this through: (1) the acceleration of vaccine development against emerging infectious diseases, and (2) securing stockpiles of investigational products to enable equitable access to those vaccines for affected populations during outbreaks. All of CEPI’s activities are structured around three strategic objectives: • Preparedness: Advance access to safe and effective vaccines against emerging infectious diseases • Response: Accelerate the research, development and use of vaccines during outbreaks • Sustainability: Create durable and equitable solutions for outbreak response capacity Together, the three strategic objectives support the achievement of higher level impacts – the sustainable development goals. By helping to mitigate the potential devastating impacts of a future epidemic of emerging infectious diseases in low and middle-income countries, CEPI contributes to the achievement of SDGs 3, 8 and 17, aligning with the priorities of the EU’s development policy. Through an inclusive and collaborative organisational model, responding to the requirements of both product development and a global health priorities, CEPI also supports the EU’s strategy for international cooperation in research and innovation. Having launched two Calls for Proposals since 2017, CEPI’s organisational model is also well tested for conducting CfPs in complex environments.

Keywords: epidemics,vaccines,global health,outbreaks
Cure Diabetes by Injection of Micro Pancreas Cell Therapy (Micro Pancreas)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel,United Kingdom
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-09-01
End date: 2024-02-29
Duration (months): 42.0
Total project cost (EUR): 3503750.0
EU funding (EUR): 2452625.0
Participants: 2
Project status: SIGNED

Diabetes is a constantly growing concern in Europe and worldwide. Patients with Diabetes suffer from lack of insulin production. Without it, glucose remains in the blood and causes significant complications that can be both short term -seizures and fainting that could result in coma or even death, and long-term - stroke, heart disease, blindness, kidney failure and limb amputation. Betalin is developing a biologic cure to Diabetes: the Micro Pancreas that after implantation under the skin (by injection) restores natural insulin production and blood glucose regulation. Micro Pancreas is a revolutionary regenerative micro-organ, based on cell therapy comprising a proprietary organ derived 3D scaffold – Micro-Organ Matrix (MOM), isolated human pancreatic islets from donors and MSCs, which reduce the risk of immune response in patients and improve the islet viability and function. Micro Pancreas eliminates insulin dependency in diabetes patients, removing the need for daily injections and injections correlated with meals, constant blood glucose monitoring and dietary constraints. Instead, patients get a biological implant by injection of Micro Pancreas, that generates insulin naturally in response to glucose, improving considerably daily life of patients with diabetes, including children with Type 1 Diabetes and moreover, preventing the long-term complications caused by the disease. Following successful feasibility studies conducted thanks to the European Commission (EC) through SME Instrument Phase 1, a growing market was identified for Micro Pancreas, due to the increasing prevalence of diabetes worldwide. Total market value is expected to more than double from $6.6B in 2013, reaching a value of ~$13.6B by 2023 in drug and treatment sales, with a CAGR of 7.6%. Betalin's project will help ease the economic burden of diabetes in National Health Services while positioning itself as a leading company in the treatment of Diabetes worldwide.

Keywords: diabetes care,cell therapy,insulin restoration
Light-induced synthesis of protein-drug conjugates for imaging and therapy (PhotoPHARMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-02-01
End date: 2027-01-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The ability to functionalise a biologically active protein with a range of different cargo molecules is crucial to accessing new tools for use in fundamental science and clinical medicine. For instance, antibody-conjugates that graft reporter molecules including fluorescent tags or radioactive metal ion chelates play vital roles in diagnostic imaging with optical and nuclear medicine techniques like positron emission tomography (PET). State-of-the-art advances in chemotherapy also take advantage of the biophysical properties of antibodies in the design of highly potent antibody-drug conjugates (ADCs) that facilitate specific delivery and uptake of cytotoxic or radiotoxic payloads to disease lesions. Surprisingly, almost all existing methods to produce protein-conjugates rely on thermally-mediated coupling chemistries. In PhotoPHARMA, the goal is to break away from the convention of using heat to drive protein functionalisation by designing new photochemical reagents that are activated by the absorption of light. Light-induced activation has the potential to solve many of the practical issues encountered in the synthesis of radiolabelled antibodies and other protein-conjugates. The work encompasses 4 main Objectives: Objective 1. Explore the biochemical scope of light-induced reactions for bimolecular protein-ligation Objective 2. Synthesis, characterisation and biological studies of photo(radio)labelled antibodies for use in diagnostic imaging and therapy Objective 3. Develop automated technologies for photoradiochemical synthesis of 89Zr-antibodies Objective 4. Establish the GLP-synthesis and Chemistry, Manufacturing and Controls (CMC) for future translation of photoradiolabelled 89Zr-antibodies to the clinic The long-term goals are to facilitate the synthesis and clinical translation of protein-drug conjugates by introducing a radical new technology based on the fast, reliable and automated approach of using light-induced chemistry.

Keywords: protein conjugation,photochemistry,radiochemistry,pet imaging,fluorophores,antibodies
ZNMF Pulsed Jet-based Active Flow Control of the UHBR-induced Flow through High Fidelity CFD (X-Pulse)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,France
Call: High Fidelity time-accurate CFD Simulations (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-02-01
End date: 2020-10-31
Duration (months): 45.0
Total project cost (EUR): 329447.5
EU funding (EUR): 329447.5
Participants: 2
Project status: CLOSED

The X-Pulse project aims at developing innovative active flow control strategies, based on synthetic pulsed jets, also referred as ZNMF, to mitigate the flow separation induced by UHBR powerplant installation on the suction side of the wing when the aircraft is operated at a relatively high angle of attack and low speed. The proposed technological solutions stand at a TRL4 level. Ultimately, they serve the improvement of the aerodynamic performances of the aircraft during these critical take-off, initial climbing and landing flight phases. This project is divided into seven work packages. Six of them deal with technical tasks, the first one being devoted to the coordination. Each work package is subdivided into specific tasks of increasing complexity. Each task falls within the scope of either the ISAE or HIT09. Thus, ISAE and HIT09 offer to join their different skills to elaborate a work-plan based on well-defined responsibilities. The major tasks are summarized below: 1. Determination of a high fidelity predictive CFD methodology able to efficiently and accurately predict the flow field around a complex geometry representative of a UHBR powerplant-equipped aircraft for real flight conditions 2. Adaptation of this CFD methodology for the high fidelity prediction of the dynamics of ZNMF pulsed jets and of their impact on the previously predicted flow field, in particular in terms of control of the flow separation. 3. determination of the optimal ZNMF-based active flow control strategy to implement on the aircraft, able to suppress the flow separation and to improve the aerodynamics performances of the aircraft during take-off, initial climbing and landing. This optimization relies on a multi-objective optimization function, by analyzing the influence of the following parameters: actuation location, including single lane and multigrid, momentum coefficient, outlet geometries, actuation frequency and amplitude modulation.

Keywords: active flow control,synthetic pulsed jets,znmf,uhbr powerplant,nacelle,pylon,flow separation,vortex interaction,high fidelity cfd,urans,optimization
Directed Evolution of Artificial Metalloenzymes for In Vivo Applications (DrEAM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 2490700.0
EU funding (EUR): 2490700.0
Participants: 1
Project status: CLOSED

In the past decade, artificial metalloenzymes (AMs) have emerged as an attractive alternative to the more traditional enzymes and homogeneous catalysts. Such hybrid catalysts result from the incorporation of an abiotic metal cofactor within a macromolecule (protein or oligonucleotide). Artificial metalloenzymes combine attractive features of both homogeneous catalysts and enzymes, including the possibility to genetically optimize the catalytic performance of new-to-nature organometallic reactions. Can artificial metalloenzymes become as catalytically efficient as naturally-evolved metalloenzymes, even in complex biological mixtures? Herein, we outline our efforts to address this challenge by localizing and evolving AMs within the periplasm of Escherichia coli. To achieve this objective, we will exploit AMs based on the biotin-streptavidin technology. Four subprojects have been tailored to address the challenges: i) knock-out deleterious components present in the periplasm; ii) improve the cofactor uptake through the outer-membrane; iii) engineer streptavidin to boost the AM’s performance; and iv) rely both on screening and selection strategies to evolve AMs in vivo. Relying on auxotrophs, we will demonstrate the potential of AMs to complement metabolic pathways. Only E. coli auxotrophs containing an evolved AM capable of producing the vital aminoacid-precursor will survive the stringent selection pressure. We have identified several selectable aminoacid precursors which can be produced by metathesis (indole, precursor of tryptophan), enone reduction (keto valine, precursor of valine) and allylic substitution (prephenate, precursor of tyrosine and phenylalanine). In a Darwinian evolution spirit, we anticipate that applying selection pressure will allow to evolve AMs to unprecedented catalytic performance. The main deliverable of the DrEAM is an engineered and evolvable E. coli strain capable of performing in vivo reaction cascades combining AMs and natural enzymes.

Keywords: artificial metalloenzymes,biotin avidin technology
Functional/Harmonic Analysis of Covariant Transforms (covtrans)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The topic of this proposal is a structured extension of abstract harmonic analysis and covariant/contravariant transforms over homogeneous spaces of locally compact groups. We are going to develop a systematic framework to study the structure and properties of convolution-type operators associated to locally compact groups, both from a theoretical perspective and in application to geometric analysis, operator theory and mathematical physics. The first objective is to present the abstract notion of relative dual space for homogeneous spaces. Then we present the theory of relative Fourier analysis over these homogeneous spaces by applying the the abstract theory of relative dual space. Finally, we explore a general model of covariant/contravariant analysis over homogeneous spaces. The entire project will be an important contribution to the field of abstract harmonic analysis, harmonic analysis, geometric analysis and theoretical physics, presenting a unified perspective on the structure of these homogeneous spaces. Applications to symbolic calculus of operators and quantum information theory will be explored. The Fellow will gain new skills and experience in applications of his knowledge in mathematical physics and other areas. Progress in this ambitious project will reinforce Fellow's reputation and support him in obtaining a strong academic position. The host will gain from Fellow's expertise, on the representation theory/abstract harmonic analysis border, which Fellow has developed from his tree-year PostDoc in Vienna--the one of world's leading wavelets groups.

Keywords: wavelets,coherent states,group representations,and signal processing
Closing the gap: studying non-obvious ligand induced degradation events (MapInDegraders)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

Inhibitor-induced target destabilisation has been reported sporadically in recent years. Importantly, despite never actually having been put in place on purpose – or by design – these effects often play a significant role towards their therapeutic effect. To date, no systematic approach to map or quantify these serendipitous destabilising events has, however, been performed, representing a huge underexplored space with large translational potential. I here propose to study ligand-induced destabilisation by utilising the plethora of available protein kinase inhibitors to systematically map their kinase degrading abilities. First, an innovative in vivo assay will be developed to monitor kinase stability at scale. Next a protein kinase inhibitor library will be screened and inhibitor-destabilised kinase pairs will be identified using automated high-throughput microscopy, coupled to fluorescent activated cell sorting and next generation sequencing. Pharmacokinetic mode-of-action binning and machine-learning based computational data mining will chart the map of ligand-induced destabilisation and delineate crucial protein, chemical and/or biophysical properties. Finally, based on the principal mode-of-action identification, measured effect size and translational potential, in-depth mechanism of action studies will be conducted for one selected inhibitor-kinase pair. To that end, a multi-omics approach consisting of genome-wide CRISPR screens and orthogonal genomics and proteomics strategies will be conducted. The project will delineate the underlying concepts of ligand-induced destabilisation using protein kinase inhibitors as a chemically well explored compound space and thus open new avenues to tap into the translationally intriguing area of designing targeted protein degraders for future medical applications.

Keywords: chemical biology,targeted protein degradation,protein kinase inhibitors,cheminformatics
Composing Philosophy: Amateurism and Aesthetics in Twentieth- and Twenty-First-Century Music (COMPHIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2022-08-31
Duration (months): 12.0
Total project cost (EUR): 112466.88
EU funding (EUR): 112466.88
Participants: 1
Project status: CLOSED

Monograph Project: Composing Philosophy: Amateurism and Aesthetics in Twentieth- and Twenty-First-Century Music Since around 1900, composers of classical music have mined philosophical texts for compositional material: in other words, they have “composed philosophy.” Starting with musical adaptations of Friedrich Nietzsche’s works, compositions that set texts taken from philosophical works, use operatic librettos on philosophers’ lives, or include a philosophical program have become increasingly common. Yet scholarship has produced a limited view of the practice, primarily due to the tendency in historical musicology to heavily privilege the works of canonical composers. And problematically, in cases where major composers have themselves “composed philosophy,” such as in Gustav Mahler’s Symphony no. 3, from 1896 (in which he sets a text from Nietzsche’s _Also Sprach Zarathustra_) or in Steve Reich’s _Proverb_, from 1995 (in which he sets a phrase from Ludwig Wittgenstein), scholars have frequently also assumed that musical mastery, or even genius, translates to an expert understanding and therefore use of philosophical material. My project offers a new view of “composing philosophy” as something done from the standpoint of philosophical amateurism—my term for engaging deeply with philosophy while being inexpert in it—irrespective of whether composers are students, canonical figures, or something in between. By looking at the larger practice of “composing philosophy” through the lens of philosophical amateurism, we can gain insight into how this seemingly esoteric practice intersects with more popularizing concepts of philosophy, the ways in which music can complicate and transform how philosophical source material is heard or understood, and the reasons that the practice has become an increasingly common preoccupation for composers.

Keywords: twentieth century musical composition,adaptation of philosophical texts,amateurism,philosophy poetry relationship,gender and sexuality studies
Investigating radiolarian biogeography and ecology with genetic barcodes (RADCODE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Radiolarians have long been recognized as a ubiquitous group of protistan microzooplankton in the world’s oceans. However, little is known about their biogeographic distributions and ecological interactions. To date, most radiolarian research has focused on their biostratigraphic fossil record, and has rarely attempted to inventory diversity, map species distributions, or determine ecological roles. Recent molecular barcoding has pioneered a more comprehensive and efficient approach to plankton research. Initial results show radiolarians to be among the most diverse and abundant clades in the sunlit ocean, with great impact on the marine food web and carbon cycle. Therefore, it is critical that we gain a better understanding of how radiolarians interact with biotic and abiotic variables, in order to accurately interpret their fossil record and predict responses to climate change. RADCODE will use molecular barcodes to explore the taxonomic diversity of poorly-known assemblages and investigate their environmental distributions and ecological interaction networks. Barcodes of deep-dwelling taxa will be identified from field samples and paired with micropaleontological classifications to develop integrated species concepts. Occurrences will be mapped globally using existing environmental DNA datasets to build the first atlas of morpho-molecular radiolarian taxa. By linking metadata from sample habitats, RADCODE will characterize the main factors impacting modern radiolarian biogeography, informing fossil record interpretation and modeling of future ecosystems. RADCODE is a highly interdisciplinary project that incorporates micropaleontological, biological, ecological, and environmental information, leading to a more unified approach to plankton research. This work will constitute a major step in my career, as I learn new research methods outside my discipline of training, and build a unique skillset that will set me apart among radiolarian workers.

Keywords: dna barcoding