Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Detection and elimination of senescent cells targeting Cyclophilin D (MitoSen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Ageing-related diseases are tightly correlated with the accumulation of senescent cells. While the selective elimination of senescent cells is a primary therapeutical goal in the field, no clinically approved treatment currently exists, which constitutes an important research gap. Abundant evidence highlights how changes in mitochondria and cellular metabolism can be both cause and consequence of the senescent phenotype and suggests a possible role of this organelle in the specific targeting of these cells. Through a CRISPR/Cas9-based screening, Serrano’s laboratory identified Cyclophilin D (CypD) as a promising candidate target, since its inactivation leads to the selective elimination of senescent cells while being non-toxic for control proliferating cells. CypD is a matrix isomerase involved in various mitochondrial functions, including the regulation of cell death and the opening of the mitochondrial permeability transition pore, a non-specific pore in the inner mitochondrial membrane, by sensitising it to calcium and reactive oxygen species. Interestingly, additional functions have been described for CypD, including proteins scaffolding, as it binds to several mitochondrial proteins, apoptosis and mitophagy control, and regulation of the electron transport chain activity. This project will study CypD as a novel, non-invasive senolytic target and provide a molecular understanding of its modulation in senescence biology, taking advantage of the various well-established senescence models developed in Serrano’s laboratory, including human and mouse cells and in vivo models. The ultimate goal is to improve the therapeutic outcome of senescence-associated diseases by developing new strategies for the detection and elimination of senescent cells in patients.

Keywords: ageing,senescence,senolytic,mitochondria,cyclophylin d,mptp,cellular metabolism
Spacious and accurate MRI machines of the future (SPAC MRI)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

We aim to pioneer the next generation of MRI machines which are less scary for claustrophobic patients, more accessible for the under-served population (e.g. obese patients, patients with medical implants in their body), more accurate for radiologists, and more cost effective for the manufacturer. We developed a novel MRI field homogenization technology, which is 50x lighter, 5x more power efficient, performs 2x better and updates 250x faster than the current state-of-the-art. For the first time, we enable real-time, precise and local control of the MRI magnetic field using a compact device. Our aim in this project is to substantiate our value proposition and evidence of safety/performance through solid data generation and disseminate the data to all relevant stakeholders to improve our market position and consolidate our long-term commercialization plans. As a company whose ultimate goal is to make MRIs accessible everywhere, we put diversity and inclusion at the forefront of our mission statement. As we head towards the next growth stage of our company, we hope to set the right diversity and inclusion goals and diversify our network through engagement with the Women TechEU program.
TRUSTWORTHY INTELLIGENT SYSTEM FOR REMOTE DIGITAL TOWER (TRUSTY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Sweden,Italy,France
Call: Fundamental Science and Outreach for Artificial Intelligence (AI) for Aviation (HORIZON-SESAR-2022-DES-ER-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 999967.5
EU funding (EUR): 999967.5
Participants: 4
Project status: SIGNED

Remote digital towers (RDT) are taking place around the world to ensure efficiency and safety. TRUSTY harnesses the power of artificial intelligence (AI) to enhance resilience, capacity, and efficiency in making significant advancements in the deployment of digital towers. The overall goal of TRUSTY is to provide adaptation in the level of transparency and explanation to enhance the trustworthiness of AI-powered decisions in the context of RDT. Through the video transmission data from RDT, TRUSTY considers the following major tasks: 1. Taxiway monitoring (i.e., bird hazard, presence of a drone, autonomous vehicle monitoring, human intrusion, etc.). 2. Runway monitoring (approach and landing) misalignment warning and the corresponding explanation. To deliver trustworthiness in an AI-powered intelligent system several approaches are considered: • ‘Self-explainable and Self-learning’ system for critical decision-making • ‘Transparent ML’ models incorporating interpretability, fairness, and accountability • ‘Interactive data visualization and HMI dashboard’ for smart and efficient decision support • ‘Adaptive level of explanation’ regarding the user's cognitive state. • “Human-centric AI” enhances the trustworthiness of AI-powered systems. • “Human-AI teaming” to consider users’ feedback to insure some computation flexibility and the users’ acceptability. To achieve the goal, TRUSTY will rely on the SotA developments in interactive data visualization, and user-centric explanation and on recent technological improvements in accuracy, robustness, interpretability, fairness, and accountability. We will apply information visualization techniques like visual analytics, data-driven storytelling, and immersive analytics in human-machine interactions (HMI). Thus, this project is at the crossroad of trustworthy AI, multi-model machine learning, active learning, and UX for human and AI model interaction.

Keywords: trustworthy ai remote digital tower transparency explanation object detection
Decocherence of Levitated Microscopic Particles in Extreme Isolation (DecoXtreme)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 2
Project status: CLOSED

One of the most intriguing features of quantum mechanics is the superposition principle, which allows a quantum object to be in two classically distinguishable states “at the same time”. Levitated objects, like nanoparticles, are an exciting platform to put the superposition principle at test, with simultaneously large masses and delocalization distances. Recently, in 2020 and 2021, the center of mass motion of a levitated nanoparticle was experimentally cooled down to the quantum regime. To achieve this milestone, the experiment had to be performed in extreme isolation conditions (e.g., ultra-high vacuum). Now the field faces the challenge to promote the high-purity quantum ground state cooled state of the nanoparticle to a more complex quantum state, which can be subsequently used for applications. DecoXtreme, is a multidisciplinary study devoted to provide the theoretical framework that allows to push the experiments with levitated nanoparticles deep in the quantum regime, by improving the current theoretical description of decoherence, envisioning strategies to mitigate its effects, and certifying the quantum properties of the observed quantum phenomena. To achieve this goal, we propose to promote the description of decoherence to move beyond the memoryless and continous noise approximations, to design decoherence protected states exploiting collective properties of levitated objects, and to analyze how to quantumness has to be certified in extreme isolation conditions. If successful, our rigorous theoretical analysis combined with the corresponding experimentally realistic constraints will uncover the path to longer lifetimes for quantum superpositions and, ultimately, lead to a better understanding of the nature of quantum phenomena.

Keywords: decoherence,open quantum systems
Toopi Regen: Unleash the power of urine to finally scale a real closed loop and regenerative farming system (Toopi-Regen)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Challenge: Novel technologies for resilient agriculture (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 3423510.0
EU funding (EUR): 2396457.0
Participants: 1
Project status: SIGNED

How can we revolutionize our food system while preserving a vital resource? 18 million tons of mineral fertilizers are used every year in the EU. This massive use threatens our food security, health and environment, but remains essential for feeding humankind. Farmers have no viable alternatives. At the same time, human urine - rich in essential nutrients, N, P, K - is not only considered as a waste, but keep threatening our water sources when flushed in drinking water (6,000B L per year in the EU). At Toopi Organics, we aim to implement a sustainable and profitable agricultural model based on up-cycling human urine. Our unique and patented fermentation process produces microbial biostimulants using urine as a growth medium for microorganisms of agricultural interest as alternative to crop fertilization. Our urine-based products are approved across Europe, safe, easy-to-use, effective (proven in many field trials) and economically viable. They are fully adapted to scale regenerative agriculture by enhancing nutrients use efficiency, increasing soil microbiome biodiversity and avoiding the huge fertilisers greenhouse gas emissions. Our closed-loop solution is implemented at a local scale and is highly replicable: urine collection (in urban areas) and urine transformation in fermentation facilities are localized close to farmer’s needs. With the EIC support, we will deploy our model in Europe and promote a significant paradigm shift in the fertilisation market. The global biostimulants market is worth €3.4B (CAGR of 11%). It remains a niche market - with products dedicated mainly to value added crops and not really affordable for field crop growers. Our ambition is to become a leader of the biostimulant market category dedicated to substitute a significant proportion of mineral fertilisers (global market worth €230B by 2030), while increasing farmers profit margin. Together, we will make a true closed-loop regenerative farming system a reality for Europe

Keywords: urine,regenerative,microbials,microorganisms,biostimulants,fertilisers,efficiency,fermentation,biotechnology,circular economy,resilience,one health,soil quality,climate change
Assessment of Learning technologies and Frameworks for Intelligent and Ethical AI (ALFIE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Cyprus,United Kingdom,Greece,Slovakia,Spain,Netherlands
Call: Beyond the horizon: A human-friendly deployment of artificial intelligence and related technologies (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 2999882.5
EU funding (EUR): 2999882.5
Participants: 10
Project status: SIGNED

ALFIE project encompasses the EthiTech Dialogue Hub (ETD-Hub) and AutoML platform. ETD-Hub is as a multi-disciplinary discussion forum where citizens, policymakers, AI professionals, and legal entities come together to engage in robust conversations surrounding the legal and ethical dimensions of AI and related technologies. The ETD-Hub serves as a collaborative space, shaping policy recommendations that influence the European Legal framework on AI, ensuring its adaptability to evolving societal and technological landscapes. Complementing the ETD-Hub is AutoML, an advanced implementation platform that seamlessly translates these deliberative outcomes into actionable AI tools and solutions. There is a bi-directional feedback loop between ETD-Hub and the AutoML platform helping to refine the policy recommendations. The AutoML platform combines two layers: Interaction layer relying on generative AI and an AutoML engine. The interaction layer contributes to the democratisation of AI by enabling the creation of advanced AI tools through interaction in natural language and speech with focus on multilinguality, while the AutoML platform finds the solutions based on the input of the user given through the first layer. The AutoML not only generates AI models and solutions that respect the EU legal framework, but also serves as a data broker providing access to a wide range of datasets contained in different platforms, with special focus on promoting unbiased and balanced AI datasets. With integrated features such as natural language processing, speech recognition, multilingual capabilities, and explainable AI, AutoML represents a widely accessible AI platform that seamlessly connects with AI-ethics through ALFIE ecosystem, and is ready to bridge legal discourse with technological implementation fostering responsible and transparent AI practices.
The Workplace as a Site of Political Preference Formation. How ‘Bridging Institutions’ Strengthen Democracy. (BridgeDem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria,Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 214344.72
EU funding (EUR): 214344.72
Participants: 3
Project status: SIGNED

How does the changing organization of work affect political conflict in advanced democracies? While we know much about the impact of labor markets on political attitudes and behavior, the workplace as a site of preference formation is largely unexplored – even if this is where a majority of people spend most of their awake time, experience contact and collaboration within and across status groups, and exchange about society and politics. BridgeDem argues that social relations at work impact affective polarization, preferences for redistribution, and support for populism, and that changing workplaces have exerted a major influence on these outcomes. Linking political behavior and political economy literatures with sociology of work & organization, it explores this argument in three ways, studying how (1) changing management styles (2) increasing vertical segregation between status groups and (3) increasing horizontal segregation between social groups in companies have impacted the political outlook of the employed. These inquiries contribute to the encompassing endeavor of building a theory of ‘bridging institutions’ – institutions that set different groups within a society into meaningful social contact and by doing so foster democracy, the workplace serving as a crucial yet underexplored case. To do so, this project leverages an innovative and mixed methodological strategy, combining (a) theory development on the basis of in-depth qualitative interviews with (b) causal identification by matching administrative employer-employee datasets with individual-level panel surveys (SOEP-IAB; LISS-CBS) and (c) assessing long-term trajectories across countries and sectors using administrative and cross-sectional survey data. This comes with an outreach initiative to unions, HRM associations and the public, promoting an understanding of the workplace not merely as a site of economy but equally as a societal ‘bridging institution’ that generates feedback on democracy.

Keywords: political behavior political economy labor sociology welfare state social policy populism preferences for redistribution affective polarization social sorting workplace
Green VALORisation cascade approach of fISH waste and by-products through fermentation towards a zero-waste future (VALORISH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Spain,Norway,Portugal,Italy
Call: Non-plant biomass feedstock for industrial applications: technologies and processes to convert non-lignocellulosic biomass and waste into bio-based chemicals, materials and products, improving the cascading valorisation of biomass (HORIZON-CL6-2023-CIRCBIO-02, 2023)
Start date: 2024-05-01
End date: 2027-10-31
Duration (months): 42.0
Total project cost (EUR): 3935845.0
EU funding (EUR): 3935845.0
Participants: 9
Project status: SIGNED

VALORISH is a 42-month action that aims to develop a computationally-assisted methodology for the design and implementation of a biorefinery with a cascade approach to valorise waste and by-products from the fishing industry at TRL 5. The target portfolio of products will be fish oil, fish protein hydrolysates, bacteriocins, pigments, vitamins, collagen and calcium-rich powder, targeting food products, additives, supplements and nutraceuticals. The cascade conversion processes will vary with the feedstock heterogeneity, comprising pre-treatment, oil green extraction, proteolytic fermentation (protein hydrolysis), fermentation with hydrolysates as substrate, and a portfolio of downstream processes. The proteolytic fermentation will be guided by computational biology, using models to search new candidate enzyme-producing bacteria. The fish protein hydrolysates obtained in the fermentation will be used, first, as food supplement due to their bioactive properties, and second, as substrate for supporting a second fermentation, to obtain high-value bioproducts, namely bacteriocins and astaxanthin, as food additives, and vitamin B12, as food supplement. Novel genome-scale metabolic models will be used to link substrate composition to the desired bioproducts via inspection of metabolic pathways and selecting optimal microorganisms. In a zero-waste aim, the fermentation side-streams will be valorised (bones by extraction and calcination, and residual biomass by anaerobic digestion). All the bioproducts will be analysed for chemical, nutritional, bioactive and safety properties to comply with EU regulation, and will be included in food/nutraceutical formulations and validated by end users. A mathematical model will be developed to simulate the biorefinery and to support the satisfactory scale-up of the core processes as well as the assessment methodologies (technoeconomic, environmental, standardisation). Social impact and acceptance of the products will be also assessed.

Keywords: biorefinery fish waste fermentation hydrolysis
The development of bio-supported homogeneous organocatalysts with improved recycling potential through sequential de- and re-polymerization and their use in CO2 valorization catalysis (RECIRCULATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-19
End date: 2025-06-18
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

The use of homogeneous catalysis is currently limited as they lack the ability to be easily recycled, and thermal deactivation of the catalyst cannot be always avoided. These features present important hurdles for the application of homogeneous catalysts in commercial processes and represents an open challenging. Designing ways to bridge the advantages properties of homogeneous and heterogeneous catalysis through the creation of supported homogeneous catalysts with well-defined active sites having high stability and recycling potential creates new incentives for circular type homogeneous catalysts with application potential in synthetic chemistry. In this project, several approaches are presented to realize this challenging goal. First, well-known N-heterocyclic bases such as TBD and DBU will be immobilized onto a biobased polycarbonate and their activity optimized in the synthesis of glycidol carbonate by a sequential catalyst testing-depolymerization-repolymerization approach. The depolymerization will be facilitated by a base catalyst, while the repolymerization will be carried out through a known procedure developed at the host laboratory. This allows to optimize and fine-tune the catalyst structure in terms of active site separation, concentration and local micro-environment. In order to be able to extend the recycling of the catalyst components to a fully recyclable system, a cross-linked version will be created and tested during an industrial secondment. A second strategy builds on a controlled copolymerization of pre-functionalized biobased monomers that feature two separate catalyst components. Their successful copolymerization and variation of their relative ratio permits the optimization of the catalytic activity of this binary system in CO2 valorization through a similar catalyst testing-depolymerization-repolymerization sequence, and ultimately to a generic process that allows to recycle a homogeneous catalyst through a unique approach.

Keywords: biobased support,polycarbonates,organocatalysis,co2 valorization,cyclic carbonates,catalysts recycling,continuous flow techniques