Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Brain cell type-specific interactions and schizophrenia (SCHIZTYPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 2064414.0
EU funding (EUR): 2064414.0
Participants: 1
Project status: SIGNED

Schizophrenia is a heritable but genetically complex disease. Pathological and epidemiological data fit a model of SCZ as a network disease with perturbations during brain development leading to early-adulthood onset clinical symptomatology. Our present understanding is based on single markers or arrays of gene expression from tissue samples containing multiple cell types. As a consequence, pathological changes in the function of inhibitory or excitatory neurons, microglia, or oligodendrocytes have variously been proposed to be the cause of symptoms. In light of recent data I hypothesize that it is unlikely that the various cellular SCZ-pathologies all arise independently from genetic alterations in multiple cell types. Recent findings from my lab show that in the cortex the expression of risk genes for SCZ are enriched in excitatory neurons, and that this set of risk-genes is largely non-overlapping with those expressed in other cell types. I propose that pathological genetic changes in excitatory cells ultimately initiates pathological changes in other cell types contributing to the multiple cellular pathologies observed in SCZ. We will: 1. Identify cell type-specific gene regulatory networks involved in SCZ (SCZ-GRNs) in prefrontal cortical excitatory cells by analysis of four distinct SCZ mouse models. 2. Confirm putative SCZ-GRNs in patient material using in situ transcriptomics on postmortem brains and connect to clinical features via collaboration with genomic studies in Sweden and Denmark. 3. Functionally investigate the effects of perturbing excitatory cell SCZ-GRNs on other cell types. Single-cell RNA-seq, providing insights into the molecular properties of individual cells, and modern molecular tools for perturbing transcription in a cell type-specific way opens up for new knowledge of mechanisms underlying SCZ pathology. My work will identify causal relationships that can be exploited for the development of strategies for personalized treatment.

Keywords: schizophrenia,human genetics,single cell sequencing,postmortem tissue,transcriptomics,mouse models
Next Steps in Securing the Sustainability of the European Social Survey, European Research Infrastructure Consortium (ESS-SUSTAIN-2) (ESS-SUSTAIN-2)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Iceland,Austria,Italy,Germany,Serbia,Belgium,Finland,Slovenia,Sweden,Hungary,Norway,France,Czechia,Netherlands,United Kingdom,United Kingdom,Portugal
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2019-2, 2019)
Start date: 2020-01-01
End date: 2024-03-31
Duration (months): 51.0
Total project cost (EUR): 4963535.0
EU funding (EUR): 4963535.0
Participants: 22
Project status: SIGNED

This proposal outlines a detailed plan for ensuring the sustainability of one of Europe’s leading social science research infrastructures - the European Social Survey, European Research Infrastructure Consortium (ESS ERIC). As a comparative general social survey the ESS needs to have generous national coverage to provide analytical power and ensure it keeps up with the changing scientific and research infrastructure landscape. Failure in one or more of these areas could damage or even destroy the infrastructure. This grant will substantially reduce the risk by securing the medium-term sustainability of the infrastructure and making it more resilient towards future challenges. The ESS has responded effectively to the ESFRI approach since it became an ERIC in 2013 and receives sizeable financial contributions from its members for core activities. ESS-SUSTAIN-2 aims to build on that support and creates sustainability through a structural strengthening of the ESS and by future proofing the infrastructure. ESS is not seeking another few years Commission funding to keep it afloat, an approach unlikely to yield long-term sustainability (and in any event these costs are now met by ERIC members). Rather it seeks a vital helping hand to help complete the transition of the ESS into a research infrastructure that is financially sound and scientifically equipped for the future. By developing links with the European Values Survey, establishing global partners, engaging with policy makers, harnessing technology to improve efficiency and cost effectiveness and launching the world’s first probability-based online panel, this proposal aims to give the European Social Survey the strongest possible foundation to succeed in the years ahead.

Keywords: european social survey,sustainability,global links,web panel,european values survey
Scribal networks in 17th-century Iceland: The patronage of Magnús Jónsson í Vigur (ICELANDIC SCRIBES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

While much work has been carried out on medieval (including Nordic) manuscripts, literary patronage, and reading culture, less attention has been paid to these issues after the Middle Ages. While the introduction of print in the 15th century certainly altered literary production throughout Europe, its influence is now understood as less definitive than was once thought, and in Iceland especially, people continued to copy books by hand until the early 20th century, keeping alive medieval scribal practices long after they had ended elsewhere. By researching the creation of new copies of popular texts and their transmission in 17th-century Iceland, I will discover how the manuscripts associated with one man at the centre of an important scribal network are linked with both the small Icelandic community in which they were produced and the wider networks of literacy and reading cultures throughout early modern Scandinavia. My project will gain insights through study of the manuscripts themselves, their scribes and patron, and also the texts they transmit. As a cross-disciplinary investigation of the society and culture of post-Reformation Iceland, my work will advance our understanding of Icelandic literature and society, and bring new perspectives to the wider fields of socio-cultural history, the history of literacy, and the history of the book. Doing my research at UCPH, which has an unbroken tradition of work on Icelandic texts and manuscripts back to the 18th century, will allow me to gain new skills through training in electronic textual editing, and to produce a digital edition of an early modern Icelandic manuscript in its entirety, making my work widely accessible to diverse audiences, alongside more traditional methods of dissemination. As Danish is a major research language in my field, living and working in Copenhagen, with the daily immersion in Danish language and culture, will also enhance my skillset and advance my career prospects in my field.

Keywords: iceland,manuscripts,scribes,literacy,early modern,textual editing,codicology,digital editing
5G Solutions for European Citizens (5G-SOLUTIONS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Ireland,Italy,Italy,Italy,Italy,Israel,Spain,Germany,Italy,Germany,Italy,Cyprus,Norway,Greece,Norway,Norway,Belgium,Greece,Greece,Belgium,Greece
Call: Advanced 5G validation trials across multiple vertical industries (H2020-ICT-2018-3, 2018)
Start date: 2019-06-01
End date: 2023-01-31
Duration (months): 44.0
Total project cost (EUR): 14286350.0
EU funding (EUR): 14286350.0
Participants: 35
Project status: SIGNED

5G-SOLUTIONS is a 5G-PPP project supporting the EC’s 5G policy by implementing the last phase of the 5G cPPP roadmap. It aims to prove and validate that 5G provides prominent industry verticals with ubiquitous access to a wide range of forward-looking services with orders of magnitude of improvement over 4G, thus bringing the 5G vision closer to realisation. This will be achieved through conducting advanced field-trials of innovative use cases, directly involving end-users across five significant industry vertical domains: Factories of the Future, Smart Energy, Smart Cities, Smart Ports, Media & Entertainment. In particular, 5G-SOLUTIONS will provide: (a) validation of more than 140 KPIs for 20 innovative and heterogeneous use cases that require 5G performance capabilities and that are expected to have a high future commercialisation potential. These use cases will be field trialled separately as well as concurrently with real end-user actors through ICT-17’s 5G-EVE and 5G-VINNI facilities, thus validating their conformance to target 5G KPIs specified for each use case, as well as their business potential, ethical and social acceptance; (b) technological enablers for facilitating the execution of the field trials in an automated way, including (i) a unified cross-domain service orchestrator enabling multi-domain slicing and 5G service lifecycle automation, (ii) an innovative smart KPI visualisation system for facilitating the near real-time analysis, presentation, benchmarking and performance validation of reference 5G network KPIs against pre-defined target values, (iii) intent-based APIs for stimulating innovation and fostering the development, portability and provisioning of new innovative applications by SMEs. Our 26-partner consortium is driven by industry heavyweights from EU telecom and vertical industries and renowned research organisations, the majority of which participate in 24 out of the 43 5G-PPP projects and in several 5G-PPP Working Groups.

Keywords: 5g demonstration,vertical industries,advanced field trials,validation,5g ppp,kpis,multi domain management,kpi visualisation
Precision Multi-Scale Predictions for the LHC: Higgs, Jets and Supersymmetry (MULTISCALE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

My project will boost the precision of theoretical predictions for collisions at the Large Hadron Collider. Precise predictions are crucial to further constrain the properties of the recently-discovered Higgs boson, and uncover a faint signal of Beyond-the-Standard Model physics. I will focus on the strong interactions, which dominate the theoretical uncertainty and play a role at multiple energy scales, including those related to the incoming protons, the hard scattering, the masses of (new) particles, the transverse momentum and size of jets. The critical progress of this proposal lies in taking this intrinsically multi-scale nature into account, moving beyond the current trade-off between precision and realism in the three dominant calculational paradigms. Fixed-order calculations are systematically improvable but assume that there is no hierarchy between perturbative scales. Monte Carlo event generators provide a fully exclusive description of the final state, but are currently limited to leading-logarithmic order and lack theoretical uncertainties. Resummed calculations can reach a higher logarithmic accuracy, but have been restricted to single observables. In a recent breakthrough, I constructed a new effective field theory that simultaneously achieves higher logarithmic accuracy in two independent observables, by factorizing the physics at the corresponding scales. Moving beyond this prototypical study, I will develop the general effective field theory framework that accounts for the relevant scales in realistic measurements, which overcomes the limitations of all three paradigms. This research will be carried out in the context of several important LHC applications: precision Higgs measurements, jet substructure techniques for identifying boosted heavy particles and supersymmetry searches. My new field-theoretic insights and more precise predictions will be critical as the LHC starts Run 2, searching for new physics at even higher energies.

Keywords: scet,factorization,resummation,precision,higgs,jets,jet substructure,supersymmetry,effective field theory,scales,renormalization group evolution
Festival of Science European Researchers´ Night 2016 - 2017 in Slovakia (ERN16-17 SVK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovakia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-05-01
End date: 2017-11-30
Duration (months): 19.0
Total project cost (EUR): 347700.0
EU funding (EUR): 248300.0
Participants: 4
Project status: CLOSED

European Researchers` Night has been successfully implemented 9times and has covered 4 from 8 regions all over Slovakia. In 2015 it took place in 6 cities, the event featured nearly 1.000 researchers and was attended by up to 160.000 visitors. Thanks to interactive presentations of scientific work and research, in very friendly and informal atmosphere, we managed to increase the interest and augmented awareness of science in general public. The main objective is to inform the general public about the inconspicuous, yet fundamental influence of the scientists within the society and to present their outcomes, which are crucial for society. The project supports also the area of regional development and intensifies interaction between hundreds of scientists. The concept for ERN 2016-2017 will have common themes to all venues and locations in Slovakia: Experience the Science (2016) and Science is the story (2017). Active participation of researchers from different institutions, various fields, focusing on various subjects of research will create great platform for showing young people how lively and impulsive could scientific career be. People will have an opportunity to spend all day visiting different presentations and stands, lectures and discussions, testing scientific applications, and getting in touch with real researchers. Thanks to these direct exchanges and discussions they can discover the "human face" of researchers and are more likely to remember their successes or stories. In 2016 we intend to prepare exceptional and bigger event in regard to 10th anniversary of ERN in Slovakia as well as the Slovak Presidency of EU Council. Unique celebration of science will be supported by various pre events and teasers and engaged more cultural institutions. Presidency of EU Council will also offer additional space for promoting ERN event as crucial part of enhancing the visibility of the Slovak and EU research.

Keywords: science,scientists,researchers,research,science show,students,children,schools,experience,story,researchers night,slovakia,10th anniversary,presidency of the council of the eu
Innovative long range daylighting system (ECHYNOXE SILICA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: France
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Daylighting reduces the need for electric light by introducing natural light into a building and improves indoor environmental quality. Numerous daylight transport systems have been developed to improve natural illumination in the deep core of buildings by means of piping light from the building envelope to be distributed in the interior space. However, the current solutions can’t bring the daylight into buildings deeper than 20 m from façade or roof, and thus are not suitable for deep-plan and high-rise buildings. The ECHYNOXE SILICA project objective is to develop a new concept of daylighting based on highly light-transmitting fibre optics coupled with Fresnel lenses. This disruptive innovation will have the opportunity to introduce sufficient ambient light levels up to 150 m from façade or roof and consequently has the potential to widen the market of daylighting systems to all types of buildings. The project is leaded by an innovative French SME, ECHY which develops daylighting devices based on fibre optics technology for natural lighting, to improve the quality of diffused light and to reduce electricity consumption. The strategy of the company is the improvement of the technology via R&D efforts while commercializing and making the first references of the technology. ECHY will conduct a feasibility study (phase 1) to prove the technical compatibility with the high-rise and deep-plan buildings constraints. The phase 1 will result in the elaboration of a business plan. The ECHY project answers to current directions towards greener buildings implying sustainable design and healthy environments for people.

Keywords: daylighting,fiber optic
Fusarium oxysporum mediated underpinning of cell type-specific modulation in multiple host interaction (FOUNDATION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Fungi have a devastating impact on human nutrition and health. Each year, fungal pathogens provoke enormous agricultural losses in crop plants and contaminating food with harmful mycotoxins. The soil-borne fungal pathogen Fusarium oxysporum infects plant root and vascular tissue, causing wilt disease in over a hundred different crops, including both dicots and monocots. A particular aggressive strain of this pathogen, tropical race 4, is threatening banana plantations worldwide. Currently, there is little information on the crucial biotrophic infection stage of vascular pathogens, from penetration of root to colonization of xylem vessels. Fusarium provides an excellent model to investigate the cell-specific sensing and adaptation and suppression of plant immunity related to early infection stages. The host group has recently reported the chemotrophic sensing mechanism used by this pathogen, and identified host plant signals perceived by Fusarium in the soil. Moreover, their work revealed a combined action of enzymes involved in fungal cell wall remodelling and plant cell wall degradation which contributes in virulence of this pathogen. In this project, we aim to identify the cell-specific virulence genes that F. oxysporum uses to colonize a dicot host (Arabidopsis) versus monocot (Banana) that has a fundamentally distinct vascular tissue architecture. We will use dual RNA-Seq coupled with Laser capture microdissection (LCM) to identify core compatibility components in both the pathogen and the plant, that are essential for establishing wilt disease. This will lead to identification and characterization of potential targets in this interaction that could be used to develop novel resistance strategies in ongoing banana breeding efforts. This project will thus advance fundamental knowledge of how a fungus senses and colonizes such a broad host range, while creating new opportunities for crop protection by dissecting the interaction at a cell-type specific resolution.

Keywords: pathogen,fusarium,cell specificity,defence modulation,compatibility
FIBRE composite manufacturing technologies FOR the automation and modular construction in shipYARDS (FIBRE4YARDS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Poland,Hungary,France,France,France,Netherlands,Netherlands,Portugal
Call: Improved Production and Maintenance Processes in Shipyards (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 7572437.5
EU funding (EUR): 5941720.01
Participants: 14
Project status: SIGNED

To ensure global competitiveness of small and medium European shipyards, a step change is needed. The key to accomplish this relies on overcoming high production costs and low repeatable quality processes which currently inhibit mass production of Fibre Reinforced Plastic (FRP) ship parts. FIBRE4YARDS will bring a cost-efficient, digitized, automated and modular FRP vessel production approach to increase EU shipbuilders’ competitiveness. FIBRE4YARDS’ objective is to match end-users’ needs with targeted advanced production technologies (adaptive molds, ATP/AFP, 3D printing, curved pultrusion profiles, hot stamping, innovative composite connections) from other competitive industrial sectors, and to transfer, adapt and combine them to improve FRP shipyards’ production and maintenance, in a Shipyard 4.0 environment. Real-scale demonstrators will be designed and manufactured to prove feasibility of technologies. Based on the targeted technologies, design and engineering of small/medium-length FRP vessels will be assessed using advanced computational tools. Compliance with the regulatory framework will be ensured, and the necessary personnel training will be provided. All within validated and viable business models targeting a circular and resource efficient maritime sector. This will lead to an improved cost effectiveness of European shipyards and their supply chain, an increased turn-over and a growth of jobs with new 21st century skillsets. Consortium’s high number of SMEs and a FRP shipyard, facilitate direct exploitation in the targeted supply chain. A robust cost-benefit analysis for stakeholders, business plans for successful commercialization and market uptake will be provided, specifically recommending an adequate IPR protection strategy. Environmental impact diminution is achieved through weight reduction (less fuel consumption), recyclable materials, energy efficient production and addressing noise pollution. The 36 months project requests 5 941 720 € funding.

Keywords: fibre reinforced plastic,design,production,maintenance,small,medium length ship,automated,modular,industry4 0