Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evaluation, control and Mitigation of the EnviRonmental impacts of shippinG Emissions (EMERGE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Spain,Cyprus,Finland,Greece,Greece,Sweden,Finland,Norway,Sweden,Greece,United Kingdom,United Kingdom,Portugal
Call: Ship emission control scenarios, marine environmental impact and mitigation (H2020-MG-2019-SingleStage-INEA, 2019)
Start date: 2020-02-01
End date: 2024-01-31
Duration (months): 48.0
Total project cost (EUR): 7493885.0
EU funding (EUR): 7493885.0
Participants: 18
Project status: SIGNED

The objectives of EMERGE are (i) to quantify and evaluate the effects of potential emission reduction solutions for shipping in Europe for several scenarios, and (ii) to develop effective strategies and measures to reduce the environmental impacts of shipping. EMERGE objectives will be achieved through real-world test cases involving measurements and modelling on actual vessels, along main shipping routes and in sensitive European marine regions. Given our unique capabilities, the EMERGE consortium is the only group that can model real world emissions of shipping to air and water for the whole of Europe. The project will collect and synthesize experimental evidence on waste streams to water and emissions to air originating from ships, for different emission control technologies. The measurements will focus on abatement techniques and will include emissions to, and concentrations in water, air and marine biota. The project will especially investigate how effectively available scrubbers reduce the effects of key pollutants. EMERGE includes five geographical case studies, in different ecologically vulnerable regions, and a mobile onboard case study. The case study regions are (i) Eastern Mediterranean (ii) Northern Adriatic Sea, (iii) the region surrounding the Lagoon of Aveiro, (iv) the Solent Strait and (v) the Öresund Strait. The mobile onboard case study will be deployed in various European sea regions. EMERGE will develop an integrated modelling framework to assess the combined impacts of shipping emissions on the aquatic and atmospheric environments, and the effects on marine ecosystems. The assessment will include the benefits and costs of control and mitigation options affecting water quality, air pollution exposure, health impact, climate forcing and bioaccumulation of pollutants. EMERGE will provide recommendations and guidance for stakeholders and decision-makers on cost-beneficial options for sustainable use of shipping on the medium and long term.

Keywords: shipping,emission control,scrubber,mitigation,environmental impact,water pollution,air pollution,emission reduction,aquatic environment,cost effective
Development of gene therapy and genome editing strategies to treat adenosine deaminase 2 deficiency (DADA2GT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Deficiency of adenosine deaminase type 2 (DADA2) caused by loss-of-function mutations in the ADDeficiency of adenosine deaminase type 2 (DADA2) caused by loss-of-function mutations in the ADA2 gene is a Primary immunodeficiency (PID) diseases characterized by vasculopathy, stroke, intracranial haemorrhages, systemic inflammation, immunodeficiency, and cytopenia. Without proper treatment, DADA2 patients are at high risk of severe disability or death. Targeted pharmacological therapies are not available, and generic immunosuppressive drugs are commonly used with unsatisfactory effectiveness. Haematopoietic stem cell transplantation (HSCT) has proven effective in patients with severe manifestations, but morbidity and mortality are high and hardly acceptable in less severe cases. Thus, safer and targeted therapeutic options for these patients need to be rapidly developed. Based on the observation that HSCT can be successful, it is reasonable to presume that strategies based on ADA2 correction in autologous haematopoietic stem/progenitor cells (HSPCs) may provide new targeted therapeutic approaches for DADA2. The main goal of this project is to establish gene therapy as a new therapeutic option for DADA2. We propose: i) to develop a pre-clinical approach of gene addition mediated by lentiviral vectors targeting ADA2 expression in patient HSPCs; ii) to exploit gene-editing technologies to prove their efficiency for correction of ADA2 mutations. Gene correction efficacy will be assessed as ADA2 expression and activity in vitro in HSPCs and iPSCs isolated from patients, and in mice humanized with patients’ HSPCs. Collectively, this proof-of-concept study will provide new and robust pre-clinical data for the application of lentiviral-mediated HSPC gene therapy in DADA2. This innovative research project is built upon the world-class research expertise developed by the researcher and the host institution in the areas of PIDs, autoinflammatory disorders, and genome engineering.

Keywords: primary immunodeficiencies,adenosine deaminase 2 deficiency,inflammation,personalised medicine
Foundations of Perception Engineering (ILLUSIVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Finland
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 2496578.0
EU funding (EUR): 2496578.0
Participants: 1
Project status: SIGNED

Virtual reality (VR) technology has enormous potential to transform society, especially as the world faces unprecedented challenges of remote work and social distancing brought on by COVID 19. Through telepresence it uniquely enhanced health care, collaborative design, education, and social interaction, all from a distance. Further benefits arise by incorporating synthetic models, which advance computer interfaces, data visualization, and immersive storytelling. In spite of its potential, the VR industry has struggled through hype cycles as devices built from co-opted component technologies fail to meet the expectations of each generation. As an industry leader in Huawei and early Oculus VR, I concluded that the struggle is largely due to the lack of a rigorous foundation that draws from scientific disciplines of perceptual psychology, neuroscience, and human physiology. I propose to reduce the gap between engineering and these human-centered sciences by developing a new field of perception engineering. In this pioneering view, the object being engineered is the illusion itself, and the physical devices that achieve it are auxiliary. This project focuses on developing mathematical foundations for VR that unify engineering concepts from robotics and control theory with their biological-system counterparts, especially predictive coding and the free energy principle. A cornerstone is von Neumann-Morgenstern information spaces, introduced for games with hidden information, which I have leveraged for fundamental problems in robotics throughout my research career. Our team will include experts from VR, neuroscience, perceptual psychology, robotics, control theory, and pure mathematics. The work will lay a foundation for principled engineering approaches to design, simulation, prediction, and analysis of sustained, targeted perceptual illusions. This would offer valuable guidance and deeper insights into VR, robotics, and possibly the sciences that study perception.

Keywords: virtual reality,robotics,control theory,perception,perceptual psychology,sensor fusion
Prevention and Screening Innovation Project Towards Elimination of Cervical Cancer (PRESCRIP-TEC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: India,Uganda,Spain,Slovakia,Slovakia,Netherlands,Netherlands,Bangladesh,United Kingdom
Call: Global Alliance for Chronic Diseases (GACD) - Prevention and/or early diagnosis of cancer (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 3265974.5
EU funding (EUR): 2998312.5
Participants: 19
Project status: SIGNED

The proposed Prevention and Screening Innovation Project towards Elimination of Cervical Cancer (PRESCRIP-TEC) will lead to effective and innovative cervical cancer screening, including direct treatment and follow-up for women in resource-poor or hard-to-reach settings in the world, by improving availability, accessibility, acceptability and quality of services. PRESCRIP-TEC will conduct implementation research into cervical cancer screening and secondary prevention in different settings in four countries over three continents: Bangladesh and India in Asia, Uganda in Africa, and Slovakia in Eastern Europe. We will analyse patient- and health services-related facilitators and barriers for uptake of cervical cancer screening in low- and middle-income countries and in vulnerable groups in Eastern Europe. By taking existing screening protocols in the four countries, we will introduce 1) interactive information with communities via mobile devices and social media; 2) client-friendly, community-based strategies, with self-test for high risk HPV infection; and 3) artificial intelligence in gynaecological examination. The use of artificial intelligence built into mobile devices offers a future for high quality diagnostics in resource-poor settings. By doing so, we will reduce the number of physical examinations and implement screenings by lower-level trained cadres. In addition, through a cost-effectiveness analysis and a business case for the global introduction of hrHPV testing as routine screening for cervical cancer, we will show the advantage of point-of-delivery testing and the benefits of self-testing for cancer in the post-COVID era, which reduces pressure on the health system. PRESCRIP-TEC will strengthen evidence of innovative strategies for cervical cancer screening as advocated by the World Health Organization and will contribute to eradication of cervical cancer worldwide through prevention and early diagnosis, alleviating the global burden of cancer.

Keywords: cervical cancer screening,cervical cancer prevention,non communicable disease,community based,artificial intelligence,protocol uptake,hpv test,cost effectiveness
Eco friendly marine antifouling paint (EKOMAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Sweden
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the proposed project as a whole (phase 1-3) is to plan, develop, secure and bring to market an innovative non-toxic and eco-friendly self-polishing boat hull paint. In the proposed project Ekomarine Paint AB will introduce the patented non-toxic anti-fouling marine hull paint to the European and the global commercial shipping market and to the global leisure boat industry. The reason why Ekomarine Paint can do this, and no one else, is that the innovation is based on a patented technology and over 11 years of research (before year 2007 research had been performed in Ekomarine AB since 2003). Exactly what we wish to achieve through the project is to develop an optimized application for commercial vessels (which is a new market for the company) and a much improved application for leisure boats (partly existing customers). This will be achieved through a well-planned project plan where Ekomarine Paint will demonstrate in full scale and in real environment, in conjunction with potential customers, the functionality, economic and environmental benefits as well as working environment improvements in various geographical and meteorological settings. In terms of technology readiness level (TRL) we will move from TRL 6 towards TRL 9 during the project life-cycle.

Keywords: evironmental friendly,ecofriendly,ecological,non toxic marine antifouling paint
Understanding cell-nanoparticle interactions through mechanobiology (MecHA-Nano)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Australia,Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 243963.6
EU funding (EUR): 243963.6
Participants: 2
Project status: SIGNED

The clinical translation of nanoparticle-based therapies over the last decade has been hampered by issues such as inefficient targeting and limited therapeutic effect. This poor translational outcome calls for deeper understanding of the biomechanics of cell-nanoparticle (cell-NP) interactions. Indeed, targeting mechanosensing-activated cell pathways is suitable for tuning cell fate and readdressing its functions, as mechanosensing components control the expression of genes involved in the cell’s migration, survival and resistance to drugs. Hippo pathway appears to be one of the most promising mechanobiology pathway, as it is involved in pathological diseases and tissue regeneration. This project aims to address the response of this pathway on cells upon interaction with nanoparticles. Indeed, tuning cell mechanosensing with nanoparticles is likely to hold great potentiality to control cell functionalities. The first objective will be the synthesis of nanoparticles of different size, shape and stiffness, using a silica scaffold coated with hyaluronic acid via metal-phenolic network assembly with exceptional physicochemical properties. The second objective consists in the application of Superresolution microscopy for studying cell-NP interactions with unprecedented detail and unveil the interaction/structure/ spatiotemporal localization of mechanosensing components related to the Hippo pathway (i.e. YAP, actin and focal adhesions) at molecular level. The third objective will be the deep analysis of the molecular biology and biochemistry of mechanosensing proteins (i.e. YAP, TAZ, RhoA and Rock), and their downstream effectors (i.e. TEAD and transcriptional factors) involved in the response to cell-NP interaction. The forth objective will pursue the analysis of these interactions using NenoVision technology (LiteScope), for measuring cell stiffness at the boundary of cell-NP contact with unique resolution.

Keywords: nanoparticles,mechanobiology,bio nano interactions
Innovative Training Network towards raising and supporting the next generation of creative and entrepreneurial cross-speciality imaging experts (HYBRID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Austria,Germany,Germany,Austria,Germany,Germany,Belgium,Switzerland,Hungary,France,France,Netherlands,Netherlands,United Kingdom,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-10-01
End date: 2021-11-30
Duration (months): 50.0
Total project cost (EUR): 3858940.08
EU funding (EUR): 3858940.08
Participants: 24
Project status: CLOSED

Modern medicine seeks to personalize diagnosis and treatment to the needs of individual patients. Personalized medicine approaches use non-invasive imaging to detect and characterize disease. While anatomical and molecular imaging systems have become a commodity, these systems have also grown complex. Complexity is further increased by the introduction of combined (hybrid) imaging systems, such as PET/CT, SPECT/CT or PET/MR. Within the context of hybrid imaging, these systems provide multi-parametric image information that has proven promising in rendering diagnoses and subsequent therapeutic management of patients more effective. The growing complexity of diagnostic and therapeutic regimens in light of the drive to integrate multiple layers of biomarker information no longer supports the operation of hybrid imaging modalities by singular specialists, but instead requires a new generation of open-minded, technology-fluent and applications-oriented experts. HYBRID will help educate future imaging experts in adopting and disseminating such a cross-specialty approach. Our idea for this innovative training network is built on our personal experience and understanding of the importance of quantitative multi-parametric biomarkers in the years to come. We propose a consortium of world-leading imaging experts and partners that present with extended experience in advanced biomarker utilization, from the development of multi-parametric imaging methods and the design and construction of hybrid imaging systems to sourcing non-image based biomarker information. We are supported by vendors of diagnostic hardware and software systems who engage in this multi-disciplinary and cross-specialty effort, as well as by scientific associations and non-governmental entities. Thus, HYBRID provides an exceptional platform to young, ambitious and talented researchers who like to engage in supporting the concept of personalized medicine through multi-parametric data.

Keywords: multi parametric imaging,personalized medicine,hybrid imaging
Advanced Transmission System for Bicycles (EVOTRANS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-11-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cycling is the cleanest transport system so far and its extended use is one of the key elements for traffic congestion and pollution decrease, especially in urban areas. City-bikes have been usually based on simple designs with a significant proliferation of fixed-transmission bikes. However the presence of hills makes this solution not comfortable enough for manoeuvring around a whole city. Multi-speed bicycles are better suited to provide a comfortable journey but appropriate managing of sprockets and chain-ring requires some additional skill that many people usually perceive as a hassle . Moreover, misuse or inadequate management of gears can often harm the big potential of bicycles as urban transport for new users. With the recent introduction of electronic shifts in the market , the path towards a simple, straight-forward, sequential shifting system that reduces the need of any sort of skill for shift management is closer. However the mechanics of current bicycle transmissions are not adequate for such a leap, especially in the case of the front derailleur which has limitations for its integration with the most modern automatic shifting systems. The goal of this project is to bring to the market a new transmission system for bicycles that will allow the integration of automatic and sequential shifting in an efficient manner (lower friction, exploit use of optimal gear ratios covering whole transmission range, lightness). A smooth automatic and sequential shifting mechanism would make multi-speed bicycles more attractive for a wider part of the population (especially for urban users) and would make the use of a bicycle in the city more comfortable for more people.

Keywords: bicycle,efficiency,ease of use
Animal and Human Nutrition Benefits of Nature Identical Vitamin E (AnNuVitE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,United States,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-09-01
End date: 2022-08-31
Duration (months): 48.0
Total project cost (EUR): 378000.0
EU funding (EUR): 378000.0
Participants: 3
Project status: SIGNED

The aim of this project is to use exchange of staff on an international and inter-sectoral basis to investigate the impact of consumption of novel nature-identical RRR-α-tocopherol in animal models on nutritional quality of animal-derived foods and in human models on bioavailability and circulating stereoisomers, and in doing so to foster a culture of research and innovation that will underpin new innovative products, services and processes in the area of animal and human nutrition. Vitamin E is represented by a suite of 8 compounds – 4 tocopherols (α, β, γ, δ) and 4 tocotrienols (α, β, γ, δ). The main function of vitamin E is as an anti-oxidant, preventing free radical-mediated lipid oxidation, particularly of membranal lipids. α-Tocopherol is the most biologically active form but α-tocopherol itself exists in 8 stereoisomeric forms arising from the 3 chiral centres it contains, RRR, RRS, RSR, RSS, SSS, SSR, SRS and SRR. Of these RRR-α-tocopherol is the most biologically active form.

Keywords: vitamin e,food trials,animal studies