Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Changing Glaciers: Enhancing International Research Capacity and Learning Collaboration in Reconstructing the Impacts of Glacier Responses to Climate Change (CHANGING GLACIERS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-07-26
End date: 2014-07-25
Duration (months): 12.0
Total project cost (EUR): 137569.4
EU funding (EUR): 137569.4
Participants: 1
Project status: CLOSED

Climate change over both geological and human timescales has an immense impact on Earth environments. Changes in mountain glaciers provide both a particularly sensitive indicator of local-to-regional patterns of climate change and are crucial for water resources and natural hazards in mountainous regions and adjacent lowlands. An international research project, led by Professor Stroeven at Stockholm University, is focused on reconstructing changes in mountain glaciers across Central Asia. As a MCIIF, Professor Jon Harbor, a recognized senior leader in interdisciplinary research and education in glacial studies, will play a central role in this international research project. Professor Harbor will co-lead the fieldwork, be a primary collaborator in analyzing results and writing journal publications with faculty and students in member states and ICPCs, and will co-lead and evaluate collaborative online international educational modules involving students in the member states and the US. His work will enhance and reinforce research excellence in both the lead member state (Sweden), and five other member states and ICPCs (Germany, Kyrgyz Republic, Mongolia, Russia, and China). Professor Harbor’s unique areas of expertise for the MCIIF include terrestrial cosmogenic nuclide methods for glacial research, and development and evaluation of novel online collaborative learning. Outcomes of the MCIIF will include a significant broadening of the competences of the host and collaborating organisations, in particular in interdisciplinary expertise and in building long-term, mutually beneficial cooperation between Europe, the USA and Asian ICPCs.

Keywords: v201 physical geography,v201 climatology and climate change,v201 geology - tectonics - volcanology,other: quaternary geology,education/learning
Chirped quasi-phasematching gratings for optical parametric chirped pulse amplification: physics, devices, and applications (CQPMAMP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

Chirped (aperiodic) quasi-phasematched (CQPM) gratings offer many advantages in the context of optical parametric chirped pulse amplification (OPCPA), including ultrabroad bandwidths, engineerable gain spectra, and potential for high efficiency via adiabatic frequency conversion. Our main goals are to investigate CQPM devices and apply them to mid-infrared OPCPA systems. We will determine the limiting factors of our current high repetition rate mid-IR OPCPA system, develop an accurate numerical model, and design improved devices. As an example, with optimal nonlinear CQPM profiles, we plan to suppress spectral gain narrowing, and thereby obtain higher efficiencies and broader bandwidths. For future experiments, increases to the power and bandwidth of our existing system are required. We plan to develop an improved seed source based on a 1-micron-wavelength thin disk laser, spectrally broadened via supercontinuum generation (SCG). Concurrent upgrades to the pump laser to hundreds of Watts power are planned. To support these powers, we will explore approaches to scaling the CQPM devices to higher power. Recent developments in SESAM mode-locked thin disk lasers have enabled high-power, short-pulse operation (580 fs, 275 W, 17 microjoules). For some applications, much shorter pulse durations are needed. One way we plan to approach this problem is by performing SCG (seed generation) followed by OPA (for efficient conversion). Due to the short pump pulses, we will develop group-velocity matched CQPM OPCPA designs. With these laser sources, we plan to perform strong-field laser-matter experiments. For example, the high repetition rates and tunability will help us to explore the wavelength scaling of several processes related to high harmonic generation.

Keywords: p106 electromagnetism,p108 optics and quantum optics,p109 lasers and laser physics
Specific Targeting of Organelles using Peptide-Polymer Vehicles (STOPP VEHICLES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

In the past ten years, research in the area of drug delivery has focused on the development of vehicles that can target specific cells in the body and on the development of vehicles that specifically deliver a drug within these cells. Today, science is going one step further and the creation of vehicles that can target specific organelles within the cell is the new challenge. In this project, I aim at creating a new generation of peptide-polymer conjugates that can specifically target the Endoplasmic Reticulum (ER) and/or the Golgi Apparatus (GA) of cells. A direct application for such vehicles is the possibility to deliver antigens into dendritic cells directly in the place where they can bind to the MHC Class I complex. Efficient delivery of antigens to the MHC Class I complex triggers the activation of CD8+ cytotoxic T lymphocytes and is crucial for the creation of novel and more efficient vaccines and adjuvants. The use of polymers for targeted antigen delivery would have many advantages, not the least being an enhanced plasma half-life of the drug, improved solubility and the possibility of controlled release. The success of this will lead to the creation of a novel generation of polymeric-based immunogenics.

Keywords: drug delivery,peptide-polymer conjugates,antigen delivery,caveolae-dependent endocytosis,golgi apparatus,endoplasmic reticulum,cholera and shiga toxins
Contrasting adaptive and non-adaptive radiations in Indo-Pacific "rats": testing alternative evolutionary models for a hyperdiverse region (CANARIP-RAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-09-01
End date: 2016-08-31
Duration (months): 36.0
Total project cost (EUR): 268781.1
EU funding (EUR): 268781.1
Participants: 1
Project status: CLOSED

Over the last 25 million years, the Indo-Pacific "rats" have undergone an explosive radiation. Their diversification has resulted in taxa with (i) a wide (putatively adaptive) and (ii) narrow (putatively non-adaptive) range of morphological disparity with or without clear ecological divergence. Adaptive and non-adaptive radiations have been replicated in three Indo-Pacific archipelagos (Philippines, Sulawesi, Papua-New Guinea), making these rodents a highly informative, yet largely unexplored evolutionary model. This evolutionary and ecological project will constitute a unique opportunity to understand the evolution of mammalian morphology in an island model as well as to understand the link between form, function, diversification patterns, and ecological divergence. This research will provide three main contributions relative to the emergence of ecomorphological diversity during both adaptive and non-adaptive radiations: (1) building an unique ecomorphological dataset for Indo-Pacific "rats" to investigate the evolution of form in our model system and exploring the link between functional morphology and ecological divergence, (2) using phylogenetic and ecomorphological frameworks to track variation in the diversification rate and in the rate of morphological evolution of species with different ecologies, and (3) simultaneously using ecomorphological, phylogenetic and macroecological datasets to understand community assembly during adaptive and non-adaptive radiations. Harvard University and Ecole Polytechnique has a great tradition of using large datasets to answer questions pertaining to patterns of evolution and ecology. Thus, the combination of a well sampled molecular and morphological framework including more than 300 “rats”, and both institutions with a history of using advanced bioinformatic and statistical methods to address evolutionary questions, should provide an ideal environment for advancing the understanding of adaptive and non adaptive-radiation.

Keywords: l803 systems evolution - biological adaptation - phylogenetics - systematics
Towards a ‘molecular factory’: Processive sequence-selective synthesis with a synthetic molecular machine (MOLFACTORY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The aim of this project is to construct a synthetic molecular machine that is capable of performing a complex task, chemical synthesis, far beyond the current state-of-the-art. Our target is to mimic translation, the process through which protein is synthesized on the mRNA template by the ribosome. Although biology uses threaded molecular architectures to transfer chemical information during sequence-specific oligomer and polymer assembly, such processes are yet to be reproduced in artificial small-molecule systems. The successful realization of the project will mark a major breakthrough in the development of artificial molecular machines that can perform real tasks at the molecular level including, ultimately, the synthesis of unnatural sequence specific oligomers and polymers that are not accessible by other routes.

Keywords: c141 organic chemistry,c140 supramolecular chemistry,rotaxane,synthetic molecular machine,fluorescence
Artificial night lights and seabirds: solutions to a fatal attraction (ECOLIGHTSFORSEABIRDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-01-01
End date: 2016-12-31
Duration (months): 36.0
Total project cost (EUR): 252215.1
EU funding (EUR): 252215.1
Participants: 1
Project status: CLOSED

During the last decades, artificial lighting have been increasing at a rate of 6% the World, increasing the light pollution levels. Currently, lighting constitutes the 16% of global electricity. The European Ecodesign Directive established a framework to phase out particularly energy-intensive lights. Until now, economic and energetic optimization has solely driven eco-friendly lighting strategies. Policy objectives should not only target economic optimisation, but also consider the cultural, social, energetic and ecological impacts of lighting technological innovations. On archipelagos worldwide, high numbers of fledglings of different seabird species are attracted to artificial lights during their first flights to the sea. This attraction causes mortality as grounded birds are vulnerable to starvation, predation, dehydration and collision with vehicles. To avoid/reduce light induced mortality, rescue campaigns are carried out in many places, and although only a few have been documented, the current information on seabird attraction to artificial lights mainly comes from these campaigns. Here, we aim to understand the mechanisms responsible of fatal attraction in order to design more eco-friendly artificial lights and more efficient rescue campaigns. We propose several innovative experiments and observational studies which are in the cutting edge of knowledge in the emerging field of the ecological consequences of light pollution. Our results will help to reduce light-induced mortality in one of the most endangered bird Order, Procellariiformes, as well as to understand the effect of light pollution on some evolutionary traits.

Keywords: v101 environment and sustainability,v108 urbanization and urban planning - cities,v304 conservation biology - ecology - genetics,v305 ecology
Organics-Metals-Salts Interactions in Food Safety and Environment Protection: Combined Experimental and Modelling Approach (O-M-S)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Croatia
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-10-10
End date: 2016-02-09
Duration (months): 28.0
Total project cost (EUR): 253809.53
EU funding (EUR): 253809.53
Participants: 1
Project status: CLOSED

Soil degradation processes in Europe like organic matter depletion accompanied with metal contamination and salinisation increasing rapidly becoming serious threat to environment. The key purposes of proposed research are i) advancing our understanding of organic matter-metals-salt interactions and their influence on metals bioavailability in soil solution, phytoaccumulation in food crops, leaching from the rhizosphere, and potential contamination of water resources, and ii) enhancing our capacity to link experimentation and modelling in advancing the knowledge of the chemical interactions. By experimental approach with horticultural crops in i) chelate-buffered and isotopic labelled nutrient solution culture and ii) soil culture will be observed the influence of factorial combination of 4 levels of organo-metalocomplexes, 3 levels of free ionic form of metals (Cd, Zn and Cu) and 3 levels of metalo-chlorocomplexes on minerals phytoaccumulation and their leaching from the rhizosphere. Chemical interactions and forms of elements in the rhizosphere with in/organic ligands and their binding to colloidal mineral/organic surfaces will be i) analytically detected and ii) modelled by chemical equilibrium software, and thereafter related with metals concentration in plant tissues. The innovation in this proposal stems from very precise metals spatial distribution (from the rhizosphere to edible crop tissues) what will be obtained by using a novel approach for studying isotope/trace element distributions in plant cells/tissues such as the NanoSIMS, i.e. the state-of-the-art in situ microanalysis by secondary ion mass spectrometry. This project will be underpinned by multidisciplinary approaches of the research team to enable rigorous science supporting practical applications to ensure food safety and protect natural resources by sustainable management of soil organic matter on metal-contaminated and salt-affected lands.

Keywords: organic matter,trace elements,salinity,chemical speciation detection/modelling,phytoaccumulation,food safety/security,environment and sustainability,agriculture related to crop production
Identification of novel regulators of translesion DNA synthesis in human cells (BIOID IN TLS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 221154.6
EU funding (EUR): 221154.6
Participants: 1
Project status: CLOSED

Here, I propose to unravel the molecular mechanisms that regulate TLS during DNA damage bypass through advanced complementary approaches. Thousands of DNA damaging insults are inflicted daily upon the genomes of all living cells. If left unrepaired, these lesions can be life-threatening for organisms as they alter the content and organization of the genetic material. To overcome this constant challenge, cells are equipped with a global DNA damage response that impacts on diverse cellular processes to facilitate reestablishment of genome integrity. The genome is particularly vulnerable to DNA damage during DNA replication, where DNA is precisely duplicated as part of the cell division process. Translesion DNA synthesis (TLS), mediated by specialized low-fidelity DNA polymerases, is an important cellular mechanism for preventing gross chromosomal instability following DNA damage encountered during DNA replication. However, our understanding of how this is achieved at the molecular level remains surprisingly limited. First, in combination with state-of-the-art mass spectrometry facilities present at the CPR, I will set up a newly established screening method, termed BioID, for efficient, unbiased identification of novel proteins that specifically act at replication forks during TLS. Second, I will mine proteomic screens for DNA damage-regulated ubiquitylation for novel TLS-regulating factors. From these screens I will select the most promising candidate proteins for further validation and characterization of their potential roles in TLS regulation. I will study how these proteins impact on TLS by establishing cell lines capable of overexpressing or knocking down each factor, and employ these in a panel of biochemical and cell-based methods established in the host lab. This project will advance our understanding of the molecular mechanisms that control and integrate TLS activity with genome integrity maintenance.

Keywords: l406 cancer and its biological basis,l203 proteomics
Linked analysis of viral and bacterial communities for better understanding of microbial biogeography and ecosystem functioning (VIRIOBACLINK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-10-01
End date: 2016-07-25
Duration (months): 30.0
Total project cost (EUR): 315923.45
EU funding (EUR): 315923.45
Participants: 1
Project status: CLOSED

Despite the intensive development of microbial ecology methods in the last decades and the recognition of the importance of the linkage between viral and prokaryotic community dynamics, the two groups are rarely studied together. The present project aims to increase our understanding of the linkage between viral and prokaryotic communities in aquatic environments and initiate a framework were the two are studied together in a multidisciplinary way with special focus on the factors determining the nature and strength of the connections between them and their ecosystem function modifying capacities. To achieve this goal a multidisciplinary microbial ecologist will be trained and the following 3 major research objectives will be addressed: 1: analysis of the global distribution of marine ssDNA phages and its correlation to the biogeography of prokaryotes coupled with the identification of the possible hosts of these phages by comparing their distribution with the distribution of other planktonic organisms. The goal will be achieved by analyzing the diversity of hundreds of samples from a global oceanic survey through a set of state-of-the-art molecular techniques and statistical tools. 2: assessment of the role of viral communities in determining the establishment success of dispersed bacterial communities. The goal will be achieved by performing several virus-free and virus-containing microcosm experiments on a diverse set of aquatic samples and comparing bacterial community composition and function in the light of viral abundance and diversity. 3: joint investigation of viral and prokaryotic diversity and biogeography of freshwaters, and assessment of the effect of the viral shunt on boreal lakes’ carbon flux. The goal will be achieved by analyzing the viral and prokaryotic diversity of subtropical and boreal lakes; measuring the viral shunt’s effect by chemostat experiments; and evaluating it in light of the viral and prokaryotic diversity and distribution results.

Keywords: v305 ecology,microbial ecology,viral ecology,biogeography,ssdns phages,dispersal,establishment success,marine,freshwater,viral shunt,metagenomics,carbon flux
Advanced Regenerator Technologies for high Capacity Systems (ARTISTE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

Today’s information society relies to an unprecedented extend on broadband communication solutions. The necessity to meet the steadily growing volume and bandwidth demand of those data services while simultaneously reducing the cost per transmitted bit has driven an enormous interest in technologies that increase system reach and aggregate transport capacity. All-optical regeneration may play a vital role as it offers a low cost and energy efficient alternative to opto-electronic repeaters for preventing the accumulation of transmission impairments and improving the system length ARTISTE project targets disruptive all-optical signal regeneration approaches to unlock the capacity of future information systems by enabling transmission of highly spectral efficient signals beyond their linear Shannon limits. The proposed concepts will be implemented using the phase sensitive amplifier as underlying technology platform along with optimized highly nonlinear fibre and semiconductor optical amplifier devices. ARTISTE approach ensures compatibility with existing fibre deployments and smooth migration towards robust and energy-efficient communication infrastructures beyond tomorrow. The aforementioned challenges require researchers highly trained in a number of relevant disciplines ranging from nonlinear science to high-speed optical communication techniques. This fellowship will provide a gifted early career researcher with the opportunity to train at one of the foremost research centers in optical communication, the Aston Institute of Photonics Technology (AITP). The AIPT will provide a suite of scientific and complementary training in to enable the fellow become a research leader in this challenging area of enormous practical relevance. The fellow will also work with a range of industry co-hosts who will enable him to appreciate the inter-sectoral elements of the problem, increase his network and fully understand the European dimension of optical communication research.

Keywords: g206 communication technology - high-frequency technology,g205 micro- and nanoelectronics - optoelectronics,g207 signal processing,g208 networks,g203 simulation engineering and modelling