Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Concepts, theories and models for planning , operating and evaluating the dynamics of Mobility as a Service (CriticalMaaS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1443250.0
EU funding (EUR): 1443250.0
Participants: 1
Project status: SIGNED

Online marketplaces enable in the travel context the dynamic matching of supply and demand. The shared economy can revolutionize urban mobility by blurring the traditional division between private and public transport, shifting from an ownership model to Mobility as a Service (MaaS). Existing transport models are designed with the premise that transport consists of either fully scheduled and controlled fleets or individual privately owned vehicles. Since MaaS breaks the conventional division between individual (ownership) and collective (usage) travel alternatives, existing theories and models of travel behaviour, transport network and operations cannot explain the behavioural dynamics, interactions and evolution of both supply-side and demand-side of the marketplace. This research program develops and tests theories and models of transport network in the domain of two-sided mobility market. CriticalMaaS will produce a set of new behavioural models of traveller and supplier choices in transport marketplace settings. The supply- and demand-side dynamics and their interactions will be mathematically formalized and developed in both network flow distribution and agent-based modelling frameworks designed for the analysis of their co-evolution. Models will be used to study emerging patterns, transition phases and critical mass concepts by testing the conditions required for generating economies of scale in market adoption and evolution of MaaS. Models will be estimated and validated using a series of surveys, choice experiments, laboratory experiments, observed behavioural data from on-demand services, focus groups and interviews. The proposed research efforts will result with several theoretical and methodological breakthroughs in the field of transport modelling. In addition, the research program will make methodological and empirical contributions to the field of travel behaviour as well as insights into the dynamics of a two-sided (mobility) marketplace.

Keywords: transport modeling,travel behavior,mobility policy,transport network dynamics,agent based simulation
Development and scaled Implementation of sAfe by design tools and Guidelines for multicOmponent aNd hArn nanomateriaLs (DIAGONAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Austria,Germany,Austria,Austria,Italy,Italy,Spain,Spain,Cyprus,Greece,Switzerland,Greece,Greece,Poland,France,Netherlands,United States,United Kingdom,Denmark,Luxembourg,Portugal
Call: Safe by design, from science to regulation: multi-component nanomaterials (RIA) (H2020-NMBP-TO-IND-2020-twostage, 2020)
Start date: 2021-05-01
End date: 2024-10-31
Duration (months): 42.0
Total project cost (EUR): 6340223.75
EU funding (EUR): 6265103.75
Participants: 24
Project status: SIGNED

DIAGONAL will bring SbD knowledge and tools to a development stage which can be implemented in the MCNMs and HARNs related industries, relying on experimental (in-vitro) and modelling (in-silico) research, to study specific hazard and exposure properties that MCNMs & HARNs exhibit along their life cycle, with emphasis in the interactions between NM constituents, with other particles and the environment, as well as their release rate and fate. While hazard and exposure determination will allow gaining understanding on the MCNMs & HARNs behaviour and evolution, multi-scale modelling will answer the questions "what are they?" and "where do they go?", through novel predictors for properties estimation, resulting from additive and/or synergistic interactions between components, as well as system-dependent properties. Ultimately, the obtained results will serve as basis to provide adapted or novel risk management guidelines, ready to use SbD tools and strategies to increase nanomaterials safety, including Sustainable-by-Design considerations, and recommendations for risk governance. DIAGONAL partners are involved in current R&D projects (NMBP-12-2017, NMBP-13-2018, NMBP-14-2018, NMBP-15-2019), networks (e.g. NanoSafety Cluster and EMMC) and working groups (e.g. OECD - WPMN and BNCT). The project will establish cooperation lines with the US nanosafety research community involving a US partner and integrating renowned US institutions on its advisory board, guaranteeing resource-efficient working plans, aligned with current EU and international efforts in the nanosafety field, and facilitating the use of existing reference platforms and databases. 7 industrial cases producing or using MCNMs/HARNs will participate providing data from scaled up scenarios, validating models, and implementing the novel SbD approaches and tools developed in the project. Exploitation activities and connection with Open Innovation Test Beds will allow mainstreaming SbD among targeted industries

Keywords: multicomponent,harn,hybrid,nanoparticles,hazard,exposure,modelling,governance,nanotechnology,nanosafety,safe by design
Resilient cooling towards climate change adaptation of cities and buildings (ResCool)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

ResCool is targeting an advanced building energy simulation to consider the thermal interactions with urban microclimate under climate change scenarios, aiming at supporting the climate-resilient design of cities under growing heatwaves. The effects of heatwaves in cities are one of the most critical overlooked issues of our time. They will occur more often and last longer, increasing the likelihood of severe and irreversible impacts for people and ecosystems. The objectives of this project are the development and validation of a holistic and reliable methodology to evaluate the heat vulnerability of cities; the identification of the climate-related hazards and risks of reference urban contexts in Europe; the selection of the best available climate-resilient solutions to strengthen resilience and adaptive capacity of cities; and the development of a climate-resilient cooling action plan and a decision-support tool for the sustainable development of urban planning policies. The project’s core research is divided into five work packages (WP). WP1 develops a bottom-up evaluation workflow of urban contexts facing climate change scenarios. WP2 validates this methodology thought data collection in two representative urban case studies in the United Kingdom and Spain. WP3 evaluates the heat vulnerabilities and climate risks of representative urban contexts. WP4 carries out a parametric analysis of resilient cooling strategies to highlight the best available solutions under climate change scenarios. Finally, WP5 uses the collected results to develop a tool to support the climate-resilient pathway by policymakers and authorities. The results will derive in context-specific policy recommendations and how governments can best incentivise, govern and regulate low-carbon and effective resilient cooling chains, improving urban planning policies, building standards and guidelines in order to ensure the health and wellbeing of citizens.

Keywords: cooling,resilience,climate change adaptation,urban microclimate,climate resilient design,building simulation,energy conservation,heatwaves,sustainable urban development
Biodiversity Community Integrated Knowledge Library (BiCIKL)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Estonia,Germany,Spain,Belgium,Switzerland,Belgium,Switzerland,Bulgaria,France,Netherlands,Netherlands,United Kingdom,Denmark
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2020-1, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 4995158.5
EU funding (EUR): 4995158.5
Participants: 15
Project status: SIGNED

BiCIKL is a proposal that will initiate and build a new European starting community of key research infrastructures, establishing open science practices in the domain of biodiversity through provision of access to data, associated tools and services at (1) each separate stage of, and (2) along the entire research cycle. BiCIKL will provide new methods and workflows for an integrated access to harvesting, liberating, linking, accessing and re-using of sub-article-level data (specimens, material citations, samples, sequences, taxonomic names, taxonomic treatments, figures, tables) extracted from literature. BiCIKL will provide for the first time access and tools for seamless linking and usage tracking of data along the line: specimens → sequences → species → analytics → publications → biodiversity knowledge graph → re-use.

Keywords: biodiversity,genomics,literature,collections,taxon names,linked open data,biodiversity knowledge graph,open science,data interoperability,reproducibility,data extraction,publishing
A novel approach to characterizing prismless enamel in modern and fossil reptiles (ENEVOLVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

ENEVOLVE is an interdisciplinary approach to test the tissue properties of dental enamel in living and extinct reptiles. This project addresses the need in functional morphology and palaeontology for quantitative methods that can characterize the structure and chemistry of prismless enamel, which caps the teeth of all non-mammalian vertebrates. Although structurally simpler than its mammalian counterpart, prismless enamel has evolved to cope with the forces of grasping and cutting through prey, crushing hard shells, and grinding plant material and it has persisted for over 300 million years. In order to assess how this enamel type has evolved to suit these disparate functions, we will integrate advanced structural, chemical, and mechanical analyses of modern and fossil reptile teeth from four dental morphotypes. By characterizing enamel under optical and electron microscopy, X-ray microdiffraction, and X-ray and vibrational spectroscopy, ENEVOLVE provides an innovative framework for describing the structural and chemical variation within prismless enamel associated with different tooth functions, and for teasing apart the key alterations resulting from fossilization. These techniques then provide valuable context for applying guided micro- and nanomechanical testing of prismless enamel, which will reveal how different prismless enamel structures and compositions help maintain teeth under different stresses. The framework and results stemming from ENEVOLVE will guide future form-function studies of mineralized tissues in vertebrates, but may also reveal new candidate structures for biomimetics and enamel restoration.

Keywords: palaeontology,functional morphology,evolutionary biology
Big Data Analytics for Time Critical Mobility Forecasting (datACRON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Belgium,Greece,Greece,France,France,United Kingdom
Call: Big data - research (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 3993835.0
EU funding (EUR): 3993835.0
Participants: 10
Project status: CLOSED

datACRON is a research and innovation collaborative project introducing novel methods for threat and abnormal activity detection in very large fleets of moving entities spread across large geographical areas.Specifically, datACRON aims to develop novel methods for real-time detection and prediction of trajectories and important events related to moving entities, together with advanced visual analytics methods, over multiple heterogeneous, voluminous, fluctuating, and noisy data streams from moving entities, correlating them with archived data expressing, among others, entities’ characteristics, geographical information, mobility patterns, regulations and intentional data (e.g. planned routes), in a timely manner. Technological developments are validated and evaluated in user-defined challenges focusing on increasing the safety, efficiency and economy of operations concerning moving entities in the Air-Traffic Management and Maritime domains. The datACRON project brings together partners from academia and industry to develop the aforementioned novel methods, together with user and data-provision partners from the two domains, in close relation to user-interest groups, focusing on real-life, industrial and user-defined challenges concerning operations (e.g. surveillance, forecasting of trajectories, characterization, etc.) regarding moving entities in sea and air.

Keywords: trajectory detection,event recognition,forecasting,moving entities
Targeting IRE1 in disease (INSPIRED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Ireland,Sweden,Greece,France,United States,Chile
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 886500.0
EU funding (EUR): 832500.0
Participants: 9
Project status: CLOSED

The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise, to develop new classes of therapeutics for these common diseases. By fostering a shared culture of research, innovation and collaboration, the participants will accelerate advances in the field of cell stress responses. The staff members who participate in the programme will develop new skills, learn new technologies and be exposed to new environments which will considerably enhance their career opportunities. Advancing drug development in the stress response field has potential translational and commercial opportunities for the participants and will benefit European society as a whole from economic and health perspectives. IRE1 is a stress sensor and signal transducer, activated in response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Its activation is part of a process termed the unfolded protein response (UPR) that determines the fate of cells in response to ER stress. The INSPIRED consortium will focus on understanding IRE1 signalling and its role in the stress response in order to target it in specific diseases such as cancers and neurodegenerative disorders where aberrant IRE1 signalling occurs. Research carried out by INSPIRED partners will develop new IRE1 modulators and generate preclinical data to support targeting IRE1 in cancers and neurodegenerative disease.

Keywords: endoplasmic reticulum er,er stress response,ire1,autophagy,cancer,neurodegeneration,therapy,drug design,unfolded protein response upr,regulated ire1,dependent mrna decay ridd
Ultrastable optical frequency comb systems (ULTRASTABLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2016-10-01
End date: 2018-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The invention of optical frequency combs revolutionized numerous fields in metrology and was honoured by the 2005 Nobel Prize in Physics. Frequency combs have many new emerging applications in optical telecommunications, broadband high-precision spectroscopy and sensing, etc. Monitoring of environmentally relevant gases and pollutants, medical sensing of biomarkers in human breath, or remote sensing of gases relevant for resources exploitation or farming are important areas, in which frequency comb systems might find large applications in the future. However, so far, frequency comb systems are mainly used in basic research, despite their large potential for commercial applications. New technology solutions are required to enlarge the application range of this technology and make it accessible for real-world systems. An important highlight in my ERC StG Mega-XUV project was the first demonstration of a stabilized optical frequency comb from a SESAM-modelocked femtosecond thin disk laser. In this context, we invented a new method for stabilization of optical frequency combs. Our new invention is to use opto-optical modulation of a semiconductor saturable absorber that is placed inside the femtosecond laser cavity. It has several technical advantages compared to the standard method, therefore we submitted a patent application for it. The Written Opinion of the International Searching Authority confirmed its novelty, inventive step and industrial applicability in August 2015. We expect that our IP will enable European industry to continue to be leading this field, because it has several advantages compared to other CEO stabilization technologies, in particular with respect to modulation speed, low nonlinearity and dispersion, and extremely high damage thresholds. With this PoC proposal, we target both the realization of technical demonstrators to bring our invention closer to the market as well as the development of an optimum commercialization strategy.

Keywords: lasers,femtosecond,frequency combs,ultrafast,metrology,semiconductor manufacturing,sensing,remote detection,health and environmental monitoring
The importance of cellular sex in physiology and the underlying mechanisms (CellSex)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 1498365.0
EU funding (EUR): 1498365.0
Participants: 1
Project status: SIGNED

The difference between males and females constitutes the largest phenotypic dimorphism in most species. In humans, this variation accounts for differences seen in the risk, incidence and response to treatment for a plethora of diseases; and much of these striking differences are not explained at this time. While sex organ-derived hormones play key roles in sculpting and maintaining sex differences, my recent work highlighted the importance of cell-intrinsic mechanisms involving the sex chromosomes. In fact, using fly models I demonstrated that the sex of intestinal stem cells plays a key role in the adult gut, both for the organ size and for the sex-specific pre-disposition to tumours. While these findings establish the proof-of-principle of the influence of sex chromosomes in adult cells, essential gaps remain to be filled. Indeed, the full range of phenotypic consequences of the presence of sex chromosomes in somatic cells, the genes, the mechanisms involved and their sites of action remain entirely elusive. My research proposal aims to understand how cellular sex impacts physiology across the body using Drosophila as an in vivo model. This question has been poorly investigated in part due to the difficulties of studying sex chromosome effects. Flies will offer the remarkable possibility of generating mosaic animals in which sex chromosomes will be genetically manipulated in defined organs. Here I will combine classical fly genetics, novel genetic methods and cutting-edge genomic techniques to: 1. characterise new cellular sex pathways driving sex differences in body size and in behaviours, 2. study the role of sex determinant coding changes in sex trait evolution, 3. achieve, for the first time, organ-specific Y chromosome deletion, and use this new method to study how the Y chromosome controls sex gap in longevity. Thus, results from this research should have major impact on our understanding of the importance of cellular sex in physiology and disease.

Keywords: sexual differentiation
Carbon 2 Butanol, a breakthrough technology in eco-innovation that cuts GHG emissions by converting industrial waste gases into chemicals and biofuel. (C2B)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

C2B is a novel microbially-mediated process that captures large amounts of CO2 from industrial plants and converts it into biofuels and chemicals. C2B process is based on Oakbio’s proprietary microbial strain, which uses CO2 from any flue gas and hydrogen (H2) as a feedstock to produce n-butanol, a valuable drop-in biofuel. In fact, n-butanol is primarily used to make durable acrylic plastics, but is also a superior biofuel, which addresses a massive market as a potential gasoline replacement. Oakbio’s microbial strain grows in a standard fermenter that can be located next to the flue stack of the factories (cement plants, power plants and refineries). It can capture flue gas directly at the point source with minimal retrofitting. This will allow such factories to cut 70% of their direct GHG emissions, while the n-butanol production adds a significant revenue stream to their bottom line: Oakbio estimates a return of more than €25 per t/CO2 captured.

Keywords: carbon capture and conversion,n butanol,biofuel,ghg reduction,microbe fermentation