Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unveiling novel deeply branching protist lineages to reconstruct major evolutionary events in the early history of eukaryotes (EUKPHYLEVOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2028-06-30
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Animals, plants, and fungi, which evolved multicellularity independently from their unicellular ancestors, represent only a small minority of the many branches on the eukaryotic tree of life, while the most of eukaryotic diversity is represented by microbial eukaryotes, or protists. Heterotrophic flagellates have been found in all major eukaryotic lineages and represent the most ancient and ancestral cellular organization. Heterotrophic flagellates often occupy early-branching or intermediate evolutionary positions within eukaryotes, thus comprehensive studies of novel lineages of heterotrophic flagellates not only fill the gaps in microbial diversity and phylogeny, but also help to understand the origin and evolution of major, well-known and diverse eukaryotic groups. Moreover, elements of the flagellar apparatus are homologous in all eukaryotes and are an excellent tool of comparative morphology to help interpret molecular phylogenetic data. The main goal of this project is to culture new and important protist lineages occupying key positions in the eukaryotic tree of life and to characterize their biology by linking sequence information to morphological, life history, and ecological traits. I propose two parallel Objectives on morphological and molecular characterization of previously unknown and understudied deeply branching lineages of eukaryotes, Collodictyonida and Rhizaria, that are both of critical importance in understanding eukaryotic evolution.

Keywords: heterotrophic flagellates,protists,early eukaryotic evolution,molecular phylogeny,morphology,ultrastructure,light and electron microscopy
NextGeneration of Battery Management Systems to increase Interoperability, bridge the Gap between 1st and SL-BESS, Extend Adaptability and emPower battery value chains. (BIG LEAP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Belgium,Germany,Finland,Spain,France,Czechia,Norway,Portugal,Italy,India,Türkiye,Lithuania,Morocco,Switzerland
Call: Battery management system (BMS) and battery system design for stationary energy storage systems (ESS) to improve interoperability and facilitate the integration of second life batteries (Batt4EU Partnership) (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 8143842.2
EU funding (EUR): 7024569.74
Participants: 16
Project status: SIGNED

Batteries have been identified as an important technology to guide the clean-energy transition. Its presence in the automotive and energy storage industry is well-established and forecasts show its incoming market uptake. However, the current BMS of FLBs lack interoperability features, resulting in a time-consuming, expensive, and non-standardized reconfiguration process for SLB adaptation. These drawbacks complicate FLB repurposing for SLB applications, like ESS. The BIG LEAP project focuses on developing solutions for the SLBs BMS and its reconfiguration process. Technology breakthroughs will be made in its BMS, as a new three-layer architecture will be designed to ensure interoperability, safety, and reliability. It will be complemented with an adaptable ESS design to ensure BMS integration and expand the SLB's potential applications. Additionally, the BIG LEAP project intends to optimize the battery reconfiguration process by making it cost-effective, faster, and standardized. The methodology for the development of these innovations includes the collection of EV, maritime E-Vessel, and ESS batteries that will be dismantled and the data collected will serve as the basis for the BMS architecture development. It will contain adaptable SoX algorithms for accurate battery measurement, a DT for real-time monitoring, and a standardization roadmap. The new BMS will be integrated into the batteries, alongside the ESS and will be tested in three demo sites. Two physical demos will be in Paris and Prague, and a virtual demo will be in Morocco. They aim to validate the novel BMS and ESS, proving their optimization and interoperability. The BIG LEAP innovation includes a multidisciplinary consortium, a strong business case, and an Environmental Impact assessment. All with the intention of accelerating its market uptake with a cost-effective solution, positively impacting the European economy through the battery value chain and tracing its sustainable benefits.

Keywords: battery management system,second life batteries
Design-based Data-Driven Decision-support Tools: Producing Improved Cancer Outcomes Through User-Centred Research (4D PICTURE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Netherlands,Spain,Sweden,Germany,Denmark,United Kingdom,Austria,Slovenia,Belgium
Call: Data-driven decision-support tools for better health care delivery and policy-making with a focus on cancer (HORIZON-HLTH-2021-CARE-05, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 9033750.0
EU funding (EUR): 9033750.0
Participants: 17
Project status: SIGNED

Patients with cancer often have to make complex decisions about treatment, with the options varying in risk profiles and effects on survival and quality of life. Data-driven decision-support tools (DSTs) have the potential to empower patients, support personalized care, improve health outcomes, and promote health equity (optimal decisions also for underserved groups). However, DSTs currently seldom consider quality of life or individual preferences, and their use in clinical practice remains limited. To address these challenges, the 4D PICTURE consortium will further develop a promising methodology, MetroMapping, to redesign care paths that include novel DSTs. We will better predict treatment outcomes by developing innovative algorithms and incorporating patient experiences, values and preferences, using AI-based models. In co-creation with patients and other stakeholders, we will develop data-driven DSTs for patients with breast cancer, prostate cancer and melanoma. We will evaluate these DSTs as part of MetroMapping as well as stand-alone, to ensure their sustainability as well as addressing social and ethical issues. We will explore the generalizability of MetroMapping and the DSTs to other types of cancer and across other EU member states. Improved care paths integrating comprehensive DSTs will empower patients, their significant others and health care providers in decision making, and strengthen care at the system level by improving resilience and efficiency. Whereas the 4D PICTURE consortium includes leaders in modelling, AI, decision making, citizen science, service design, ethics, risk communication, and policy making, this project will impact clinical practice and science across Europe and beyond.

Keywords: shared decision making service design citizen science ethics prognostic modelling patient preferences personalized care interdisciplinary cost effectiveness care paths implementation science
The Social Isolation and Loneliness in Europe Network: Evidence-Based Policy Recommendations on its Causes, Consequences, and Monitoring (LONELY-EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Coordination and support actions
Countries involved: Germany,Netherlands,France,Italy,Poland
Call: Policy recommendations from socio-economic impacts of loneliness in Europe (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 3239700.46
EU funding (EUR): 2999283.28
Participants: 7
Project status: SIGNED

The LONELY-EU project tackles the pressing societal issue of Social Isolation and Loneliness (SIL) across the EU through a unified strategy, engaging stakeholders at every level. LONELY-EU aims at facilitating the exchange of knowledge and practices, connecting SIL stakeholders, and supporting and encouraging decisionmakers to adopt targeted and evidence-based policies to prevent and mitigate SIL on local, regional, national, and EU levels. The LONELY-EU consortium combines scientific expertise, policy expertise, and networking and communication expertise from a diverse array of EU nations. This consortium is guided by its Evidence-to-Action Advisory Board and supported by the WHO, OECD, and other global entities. LONELY-EU will work towards the five expected outcomes in three separate pillars. In Pillar 1, the empirical cornerstone, LONELY-EU will apply advanced statistical methods to analyze pooled existing data, creating a comprehensive, dynamic, open, accessible, and sustainable evidence map that sheds light on the socioeconomic causes and impacts of SIL at the individual and societal level. In Pillar 2, the policy foundation, LONELY-EU will craft the European Social Isolation and Loneliness Index, establishing a groundbreaking framework to monitor SIL across the EU. Pillar 2 will also draw on empirical findings from Pillar 1 to provide evidence-based recommendations for preventing, combatting, and monitoring SIL in Europe at both individual and population levels. In Pillar 3, dedicated to networking and dissemination, LONELY-EU will leverage established networks to build the SIL Network Europe, an EU-wide network of SIL stakeholders under the patronage of Vice President Evelyn Regner and Minister President Hendrik Wüst. Pillar 3 aims to execute a comprehensive impact strategy covering all steps of Communication, Dissemination, and Exploitation to maximize the longevity of the project and its impact towards a more resilient and connected society.

Keywords: loneliness,social isolation
Human footprint on water from remote cold areas to the tropical belt. INtegrated Approach TO secure water QUAlity by exploiting Sustainable processes (IN2AQUAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Denmark,France,Spain,Greece,Norway,Tunisia,Germany
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 4108124.31
EU funding (EUR): 4054233.6
Participants: 22
Project status: SIGNED

IN2AQUAS will train 15 doctoral candidates (DCs) for facing the complex challenge of envisaging the pollutant impact on the environment and of tailoring the proper treatments for the production of safe and clean water -also in extreme environments- using green approaches through high quality research, training, management and innovation. This goal will be attained via a structured training-through-research programme, consisting of original individual research projects and education on technical and transferable skills. Experts from 10-degree awarding universities, 4 national research centers, 1 associated university, 4 companies and a highly qualified mindfulness-in-the-workplace facilitator will join forces to facilitate the successful training programme that will allow DCs to be awarded with a double doctoral degree in two different countries. These aims will be pursued by applying different actions, which include the study and development of innovative technologies against the water pollution, paying attention not only to the sustainability of the water management systems (in a circular economy vision), but also to the reuse of water, the recovery of nutrients and the green synthesis of functional materials. The developed technologies will be tailored to variegated scenarios with particular emphasis to three case studies: aquaculture, arid areas and (remote) cold areas. The overall research goals will imply three main steps: 1) the assessment of water quality and the prediction of its response toward the increased environmental stresses; 2) restore water quality while approaching the zero waste discharge and 3) scale up and process integration. The multidisciplinary, interdisciplinary and intersectoral network will forge creative entrepreneurial and innovative scientists, who will be equipped with the skills, tools, insights and flexibility that enable them to be the next generation of Urban Water System management innovators.

Keywords: water pollution,sustainable processes,water quality,integrated water treatment,nutrients recovery,water reuse,pollutant fate,prioritized pollutants,photocatalysis,hrms
INTERnational Cooperation of high containment research infrastructures: from Epidemic Preparedness TO Response (INTERCEPTOR)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Belgium,France,Sweden,Portugal,Hungary,Austria,Spain,Germany,Switzerland,Australia,United States,United Kingdom,South Africa,Canada,Singapore,Malaysia,Italy
Call: Strengthening the international dimension of ESFRI and/or ERIC research infrastructures (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1498076.69
EU funding (EUR): 1498076.69
Participants: 19
Project status: SIGNED

Emerging infectious diseases (EID) do not respect borders. They rank as global catastrophic risks for humanity, along with climate change and biodiversity loss. The COVID-19 pandemic showed how coordination of global research, through cooperation, and sharing of data and expertise, are crucial for efficient and effective preparedness to EIDs, and vital for a rapid response. Nevertheless, there are still major challenges limiting global cooperation among high containment laboratories (HCLs). HCLs are critical infrastructures for the development of medical countermeasures (e.g., vaccines and therapeutics) against high consequence pathogens. In order to fulfil its role, and given the global threat of EIDs, the European Research Infrastructure on Highly pathogenic Agents (ERINHA), together with its partners, proposes to establish and reinforce interactions with HCL research infrastructures (RI) worldwide, to strengthen pandemic preparedness and response capacities. INTERCEPTOR (INTERnational Cooperation of high containment research infrastructures: from Epidemic Preparedness TO Response), a consortium with key HCLs from Europe and across the world, will focus on access provision to HCLs, enhancement of the human capital of HCL, including in biorisk management, critical resources sharing, harmonisation and interoperability. The proposed actions will help ensure broader access to state-of-the-art HC facilities, while respecting the necessary biosecurity and biosafety constraints, and promote the establishment of a sustainable global network of HC RIs. By expanding access to HC RIs, strengthening the human capital base, promoting sharing of knowledge, skills and experience, and providing opportunities for common training programmes and staff exchanges, INTERCEPTOR will reinforce the next generation of HCL researchers and facility managers, and extend the opportunities for access to HCLs, required to push the boundaries of science and innovation in the field of EIDs.

Keywords: research infrastructure international cooperation high containment laboratory bsl3,bsl4 pathogens service provision bio risk pandemic preparedness global health interoperability
Sustainable rubber for the environment. (NORDIC BIO-RUBBER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-07-31
Duration (months): 30.0
Total project cost (EUR): 3636297.25
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Current rubber sources are unsustainable. Existing rubber products are derived from natural rubber from the rubber tree. The problem with the source of this rubber is deforestation of tropical rainforest and competition with food production. Rubber plantations are threatened by climate change and are vulnerable to disease and environmental hazards. Almost the entire global supply of natural rubber – some 11 million tonnes in 2015 – comes from Southeast Asia. Scientists at Edinburgh’s Botanic Gardens estimated that more than 50% of plantations in the region might not be sustainable. The second source of rubber is synthetic fossil-fuel based rubber. It is mixed with strong chemicals during production. NORDIC BIO-RUBBER facilitates the transition of fossil-centered industry of today to a sustainable bio economy, allowing us to build a Europe based supply chain, decreasing dependencies on Asia for the production of consumer goods, which translates to a more robust economy.

Keywords: recyclable rubber,bio refinery,sustainability,bio rubber,new value chain,environmental engineering
Mystical Emotions and the Limits of Language in Contemporary Italian, French, and English Literatures (MYS-SPEAKED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: CLOSED

This project will contribute to an emerging research field dealing with mysticism in contemporary literature, and represents the first attempt to study contemporary “mystical literature” from both an interdisciplinary and comparative standpoint. The framework addresses the connections between “mystical emotions” and language, pushing the boundaries between literary analysis, the philosophy of emotions, and the philosophy of language. Unlike many contemporary studies in Literature and Religion—that mix or interchange concepts such as “mysticism”, “sacred”, “epiphany”, etc.—this project advocates for an accurate definition of “mysticism”, from both a historical and a philosophical perspective. The overall objective of this project is to map and examine the phenomenon of “mystical experience” through a multilingual and contemporary literary corpus that transcends the limitations, related to the timespan and the religious context, of even the most important academic research in this field. The key outcome of this theoretical and literary inquiry will consist of a classification of “mystical emotions” in contemporary literature in different languages (English, French, and Italian), including a description of the main features and attributes of mystical emotions and experiences. The research outputs will be crucial additions to the current state-of-the-art, and will represent an essential contribution to enhance interreligious dialogue as well as map spiritual imaginaries in contemporary European culture.

Keywords: literature and religion,contemporary mysticism,mystical literature,literature and emotion,western esotericism
Hydrogen oxidizing bacteria engineered to valorize CO2 for whey protein production (HYDROCOW)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Finland,Netherlands,Germany,Switzerland
Call: EIC Pathfinder Challenge: Carbon dioxide and Nitrogen management and valorisation (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 3963836.25
EU funding (EUR): 3963836.25
Participants: 4
Project status: SIGNED

Milk protein plays an important role in our nutrition, however classical milk production has significant environmental impacts, from greenhouse gas (GHG) emissions to extensive land demand. Project HYDROCOW addresses these challenges through a net-zero carbon dairy protein production platform. The main objective of the project isto develop and demonstrate a bacterial protein secretion system where CO2 and soon N2 is valorised into food-grade protein, decoupled from agriculture. This system will base on the first-of-a-kind engineered hydrogen oxidizing bacterium (eHOB) Xanthobacter sp. SoF1. As a first product the main milk component beta-lactoglobulin was chosen. Technically this will be achieved by implementing a Design-Build-Test-Learn (DBTL) cycle linked to a validation and scale-up phase allowing to iteratively optimize the production of secreted protein. The project will deliver key technologies – A) an innovative eHOB protein secretion system; B) predictive eHOB metabolic models, genetic engineering tools, and a novel high-throughput (HTP) screening system for DBTL cycling; and C) the methods for validation and scale-up – with immediate and long-term impact on the production of food and nutrition, materials, medicines, fuels and chemicals. In the long-term, the proposed platform has the potential to not only replace conventionally produced food proteins but also deliver proteins for materials or therapeutics, important for human and animal health. In comparison to current standard microbial production processes our platform does not compete with human nutrition for valuable feedstock, such as glucose, and therefore will contribute to a sustainable development of our society. HYDROCOW will generate significant knowledge for a growing research and application community about autotrophic, microbial production systems, their physiology, and sophisticated tools for genetically designing and screening them.

Keywords: molecular biology,computational biology,alternative proteins,bioprocess engineering,fermentation technology,