Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
How the dynamics of personality variation, food intake and social interactions determine anti-predator escape (DynFish)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-05-14
End date: 2023-05-13
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Escape responses (reaction to a threatening stimulus) are widespread in the animal kingdom and are critical for survival in many species. In recent years, it has become apparent that individuals differ consistently from one another in their behaviour, often called ‘animal personality variation’. Boldness refers to the extent to which animals take risks, and is a major personality trait that has important ecological and evolutionary implications. While it is widely accepted that the trade-off between exposure to predation risk and the benefit gained from it (e.g., greater access to food) generates personality variation in boldness, how and why bolder individuals are more likely to be preyed upon remain to be investigated. Furthermore, personality variation is also common in social species. Despite the extensive research on collective vigilance, personality variation has rarely been considered in this context. In this project, I will study how the relationship between boldness and food intake shapes anti-predator escape responses, shedding light on how the mechanisms of the food-mortality trade-off generate personality variation in boldness. For this purpose, I will first conduct experimental work on individuals and groups of three-spined stickleback (Gasterosteus aculeatus). Individuals and groups will be tested in a setup allowing me to precisely control the behaviour of a predator model and study how escape responses vary with individual boldness, food intake and social interactions. Second, I will couple this experimental work with computer simulations to 1) fully characterise the food-mortality trade-off, 2) elucidate the mechanisms underlying individual differences in boldness, and 3) give new insights into the evolution and maintenance of personality variation under predation risk in different ecological conditions.

Keywords: escape response,animal personality,food intake,collective behaviour,swarm,fish,stickleback
METLINK: Identification of links between cancer cell growth and metabolism genes. (METLINK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-12-31
Duration (months): 27.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 2
Project status: CLOSED

Metabolism is crucial for cellular survival. The large amount of evidence covering metabolic entries is mainly about the enzymatic processes and single reactions happening within the metabolic map, but there is poorer understanding of the cellular growth signaling network and regulation around metabolism. With METLINK we aim at identifying new and previously undiscovered selective links between metabolic genes and cellular growth pro-survival mechanisms. The hits will be identified with the use of a pooled libraries of CRISPR/Cas9 lentiviral vectors against metabolic genes and cell cycle/ cancer genes. The metabolic library targets will be divided into sub-pools (carbohydrate metabolism: 245; inositol metabolism and lipid metabolism: 571; tricarboxylic acid (TCA) cycle, respiratory chain, integration energy metabolism: 240; nucleotide metabolism, vitamin synthesis and biological oxidations: 361; amino acid metabolism and protein processing: 667; others: 355) and therefore be amenable to medium-throughput screening and selected metabolic processes interrogation. The cancer/cell cycle genes target will be approximately 500 genes. The screening will be initially performed on the human fibroblasts BJ and IMR90, easier to genetically modify, and later validated in other relevant cancer cell line. This will result in the identification of new Achilles’ heels in cancer within metabolism and propose new druggable targets. They will be validated and screened with a library of compounds actually present at SciLifeLab within Karolinska Institute. Lately this proposal will elucidate potential links between oncogenes or cellular growth genes and metabolic genes providing new avenues for treatment within metabolic reactions.

Keywords: cell cycle,crispr,cas9,synthetic lethality,metabolomics
Monitoring built-Up area from SAtellite (MUSA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Italy
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 72500.0
EU funding (EUR): 72500.0
Participants: 1
Project status: CLOSED

Survey Lab is a spin off company of Sapienza University devoted to scientific and technological knowledge-transfer in order to capture additional business opportunities in the field of civil and environmental engineering. The company core business is the development and commercialization of innovative geomatic monitoring systems based on advanced surveying and mapping technologies. A specific focus is on the assimilation of remote sensing data obtained by Earth Observation satellite sensors into ground-based monitoring and modelling procedures. Survey lab has recently obtained a Grant from European Commission through the SME Instrument phase 2 in the topic Space with the project I.MODI. Presently, the main business strategy of the company is to develop innovative value added services and products with a particular focus on Copernicus Earth Observation Programme. To reach this goal the company needs to strengthen its expertise on the development of advanced geostatistics tools that will be tailored to services that are currently still under development. Therefore, a specialist with a solid background in geospatial data analysis and experience in software development is needed. To this day, Survey Lab hasn’t be able to the recruit a highly qualified specialist on Italian national job market, due to the lack of University Courses in this specific field. On the contrary there are many post-graduate, masters and phd courses active in other EU countries with solid experience in statistic and programming language (such as Geo-Information Science and Earth Observation University of Twente, Delft University of Technology, etc.). We believe that the required expertise could lead to a significant growth of Survey Lab capability in the implementation of advanced numerical tools, necessary to improve the data analyses procedures.

Keywords: geostatistical analisys,eo data,downstream service,civil infrastructure monitoring,urban areas
Using Nannofossil Chemistry to constrain the cellular response of marine phytoplankton to changing carbon dioxide concentrations in the surface ocean (NannoChem)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2022-11-03
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

NannoChem aims to determine whether long-term changes in atmospheric carbon dioxide (CO2) impact the coupled processes of photosynthesis and calcification within the coccolithophores, a key group of marine phytoplankton. Recent studies proposed that the availability of dissolved phase CO2 in the surface ocean is a primary control on coccolithophore cell size, calcification rates and evolution. If true, this has major implications for primary production in future high CO2 oceans. Here we propose to test these hypotheses by generating a unique set of multi-proxy records of coccolithophore chemistry, cell size and calcification over the past 10 million years. These records will come from an exceptional new late Miocene to modern sedimentary archive of unprecedented quality, recovered from the eastern equatorial Indian Ocean during the International Ocean Discovery Program Expedition 363 (Oct-Dec 2016; West Pacific Warm Pool). NannoChem will go beyond existing studies, and generate a new state-of-the-art, by: 1) generating the first direct record of coccolithophore carbon isotopic vital effects by comparison with planktonic foraminiferal estimates of the isotopic composition of surface ocean dissolved phase carbon; 2) generating the first long-term records of coccolithophore calcification across all main placolith-forming families; 3) constraining other potential controls on coccolithophore vital effects by generating paired records of cell growth conditions; and 4) working with Expedition 363 scientists to constrain the impact of long-term changes in cell physiology on organic biomarker (alkenone) estimates of Neogene atmospheric CO2 concentrations. NannoChem will deliver exceptional training and three-way knowledge transfer between the Experienced Researcher, the Host and Secondment Partner (Prof. Beaufort, CEREGE). This unique combination of specific skills and expertise is required to deliver NannoChem's ambitious and important research objectives.

Keywords: coccolithophores,nannofossils,paleoceanography
Synthesis of Hybrid Metal-Semiconductor Tetrapod Photocatalysts for Improved Water Splitting (HMST-PC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 170509.2
EU funding (EUR): 170509.2
Participants: 1
Project status: CLOSED

While modern photovoltaic cells (PVCs) are capable of efficiently and directly generating usable electricity from sunlight, daily variations in availability of this key resource during day/night cycles points to a need to store the generated power for use when the PVCs are not active. To this end, systems that directly use the energy of sunlight to drive chemical reactions that otherwise would be thermodynamically uphill have been vigorously studied since the late 1960s. Such “solar-to-fuel” generating systems are targeted to store energy from sunlight in the form of chemical bonds which can be later broken with mild external stimulus to provide energy on-demand. Of these systems, the most studied for the collection and storage of solar energy is the photoinduced solar water splitting reaction, wherein liquid water is broken down into hydrogen gas (H2) and oxygen gas (O2) using semiconductor photocatalysts. This proposal seeks to develop a novel nanoscale Hybrid Metal-Semiconductor Tetrapod Photocatalyst (HMST-PC) for solar energy conversion. This catalyst is specifically designed for the efficient generation of fuels (H2 and O2) from only sunlight and H2O. The nanocatalyst will consist of: i) four light-absorbing CdS antennae, ii) an embedded CdSe core to guide internal energetics, iii) a binary noble metal cocatalyst for H2 evolution, and iv) a robust metal-oxide cocatalyst for O2 evolution. In addition to developing an all-in-one solar photocatalyst, fundamental scientific advances made in this action will serve to i) expand the toolbox of precision nanomaterials synthetic methods available to researchers, ii) address long standing issues of charge-extraction in nanoscale catalyst systems, and iii) develop new methods to stabilize functional photocatalysts against photocorrosion. These advances will help enable future researchers to engineer better (more well-defined) model systems with a level of synthetic precision not available in the past.

Keywords: nanomaterials,semiconductor,photocatalysts,water splitting,colloidal nanocrystal,cdse cds
Co Production and Co Governance: Strategic Management, Public Value and Co Creation in the Renewal of Public Agencies across Europe (COGOV)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Slovenia,Croatia,Croatia,France,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Understanding the transformation of European public administrations (H2020-SC6-CULT-COOP-2017-one-stage, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 4483898.75
EU funding (EUR): 4483898.75
Participants: 10
Project status: CLOSED

This proposal suggests that taking a strategic approach – in the most fundamental sense - to the renewal of organization and management of European public administrations is a key requirement for the bettering of public governance and citizens’ participation across Europe. The project aims to locate, explore and diffuse leading edge experiments in new and more participatory approaches to public administration which are becoming evident across various countries in Europe. Ultimately, the project aims at generating applicable knowledge about the dynamics and developmental patterns of longitudinal, emergent strategy formation processes and the dynamics leading to strategic renewal and community engagement. We draw on four promising models apparent in the recent public management literature to inform the empirical work theoretically, namely: Public Value Creation models, used in combination with Co Creation and Co Governance (hence the acronym COGOV) ideas, in turn combined with Digital Era Governance inspirations with their possible implications for more participatory approaches to e-government. The project relies on a pan European collaboration of academic and policy partners and is strongly connected to, and informed by, practice.

Keywords: public value,co production,co creation,network governance,digital era governance
RNA particles for Preparedness against Infectious Diseases (RAPID)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

BunyaVax builds unprecedented technology for cost-effective and rapid development of vaccines against newly emerging viruses. The platform can be a valuable tool in quickly controlling the spread of new virus strains among populations. The timing of RAPID closely corresponds with a current focus of the vaccine industry on novel vaccine platform technologies that enable rapid response to emerging threats. The BunyaVax RNA particle technology combines the efficacy of live vaccines with the safety of inactivated or subunit vaccines – which are currently the standard vaccine technologies. A unique characteristic of the RNA platform is that it allows for ‘plug and play’ application. Any gene can be plugged into the RNA particle genome to generate inherently safe and efficacious vaccines. The platform can stably express a broad variety of pathogen derived antigens. A major advantage is that development and manufacturing can be completed in a timeframe of 16 weeks which is at least twice as fast as current methods. The BunyaVax technology is in a stage of proven efficacy in sheep. RAPID is designed to prepare for partnerships with vaccine manufacturers and/or venture capital firms and to lay the foundation for clinical application of the vaccine platform. Key steps for upscaled production levels will be taken. The innovation project is at the core of the strategy of BunyaVax. The project is instrumental for reaching a stage in which commercial partnerships can be explored. Ultimately, this will allow BunyaVax to forward the technology to a stage in which industry can use it to develop vaccines for controlling veterinary and human infectious disease outbreaks at an earlier stage than currently possible.

Keywords: plug and play vaccine technology
The sources of historical signal in the genomes of birds (EvolInfome)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

Genome-scale sequence data play an important role across the biological, medical, and agricultural sciences for extracting the signatures of divergence among species and populations. Multiple basic biological forces influence the evolutionary information content of genomes, leading to substantial variation across genomic loci and lineages. Models of molecular evolution for phylogenomics are routinely used for extracting information about evolutionary history, and ultimately for making inferences of the relationships and amount of evolutionary change among taxa. However, existing phylogenomic methods are not amenable for identifying the impact of specific drivers of historical information across whole genomes. The present action will develop tests in the framework of model adequacy for assessing the impact of the primary evolutionary forces on the genome. Assessment of model adequacy proceeds by comparing simulated data under a given evolutionary model with empirical data. The novel framework will be tailored at whole-genome analysis. It will allow a comprehensive examination of the sources information signal left by basic evolutionary forces, such as speciation, mutation, selection, recombination, and drift. The new methods will be disseminated through an intuitive software package that will be openly available for researchers across biological sciences. Examining the sources of evolutionary information will allow improved phylogenetic inferences and guide model improvement. An unparalleled genomic resource of the genomes of every avian family, soon to be released by the host, will be examined in detail with the methods developed. This will provide insights into genome evolution in birds and inferences of their evolutionary history with unprecedented confidence.

Keywords: molecular evolution
Overcoming the salinity barrier (SALICROP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Salinity is among the major global burdens limiting food production, natural or human induced, ~20% of the global irrigated soils are already affected by salinity. Seed producers, aware of the billion-dollar business opportunity, have tried to overcome the salinity barrier without success. Salicrop Ltd, a Israeli Agtech startup, develops seed treatments for saline soil and water, which enables growing crops on marginal land and/or irrigation with brackish water. Salicrop finalized its Proof of Concept (POC) with numerous successful trials of tomatoes, peppers, spinach, rice, wheat and corn with average of 30% increase in crop yield under salinity conditions. After successfully piloting the prototype version of seeds treatment bio-technology, the team can confirm the capability of its breakthrough product to open new markets starting in Europe with the potential for rapid growth, licensing our technology to key seed players to obtain a salt-tolerant version of their own commercial seed-varieties. By pursuing the present feasibility study, Salicrop’s management team aims to improve its understanding of international market conditions and the associated risks as the company develops a deeper business plan for rolling out and scaling up seed treatments licensing as a marketable innovative solution. SME Instrument Phase-1 and Phase-2 will be extremely beneficial in helping the company to accelerate development and market penetration of the developed solution in target segments, boosting the company’s growth to 28 employees and $53,500,000 revenues by 2025.

Keywords: seed treatment,agriculture,crops,food security,hunger,farmer,soil protection