Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Well-Aging and the Tanycytic Control of Health (WATCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Spain,France,France
Call: ERC Synergy Grant (ERC-2018-SyG, 2018)
Start date: 2019-03-01
End date: 2026-02-28
Duration (months): 84.0
Total project cost (EUR): 9866250.0
EU funding (EUR): 9866250.0
Participants: 4
Project status: SIGNED

The survival of an organism depends on energy homeostasis, involving the control of neuroendocrine functions that integrate metabolic feedback and adapt the response of the organism to physiological demands. Tanycytes, specialized glial cells lining the floor of the third ventricle in the median eminence of the hypothalamus, act as linchpins of these processes, dynamically controlling the secretion of neuropeptides by hypothalamic neurons into the pituitary portal circulation and regulating blood-brain and blood-cerebrospinal fluid exchanges, both processes that depend on their morphological plasticity in response to the physiological state. In addition to their barrier properties, they actively shuttle circulating metabolic signals to hypothalamic neurons that control food intake. The overarching goal of WATCH is to synergistically employ state-of-the-art technologies in systems neuroscience, mouse genetics and bench-to-bedside research, to explore the role of these unique and versatile cells, providing new directions in biomarker research and new therapeutic approaches for a variety of disorders that impair well-aging. Our specific aims are: 1. Genetic dissection of the in vivo regulation, pathophysiological function and molecular markers of tanycytes classified according to their anatomical location. 2. Identification of novel heterogeneous, molecularly distinct tanycytes and associated endothelial cells and determining how these characteristics evolve under distinct physiological and pathological conditions. 3. Functional validation of newly classified subgroups of tanycytes and the specific modulation of the activity of these subgroups at the experimental level. 4. Exploration of the functional consequences of pharmacologically activating pathways required for the tanycytic shuttling of metabolic signals on their CSF levels of these factors, hypothalamic activity and cognition in animal models and patients with morbid obesity or age-related cognitive deficits.

Keywords: tanycytes,energy homeostasis,hypothalamo pituitary neuroedocrine axis,aging,neurodegenerative disorders,hypothalamus
The DIffuse Galaxy Expansion SignaTures In Various Observables project: understanding the emergence of diffuse, low surface brightness galaxies and the link to their dark matter haloes (DIGESTIVO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-05-22
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

I propose to carry out the ‘DIffuse Galaxy Expansion SignaTures In Various Observables’ (DIGESTIVO) project, a joint theoretical and observational effort alongside observers at the Instituto de Astrofisica de Canarias (IAC), to study the evolution and formation of Low Surface Brightness galaxies (LSBs), including the recently discovered Ultra-Diffuse Galaxies (UDGs). LSBs are extremely dark matter dominated, faint objects hardly distinguishable from the night sky. In the last decade it has became clear that large numbers of LSB galaxies exist, opening a new window on galaxy evolution and formation. How do such diffuse galaxies form and evolve? How are they linked to their dark matter haloes, and how do they fit within the current cosmological model of galaxy formation? To answer these questions, I will make use of state-of-the-art, sophisticated hydrodynamical numerical simulations of galaxies, my field of expertise, combined with new observational data of LSBs/UDGs, which will be attained by observers at the host institution thanks to new techniques that will push the frontier of LSB imaging with optical telescopes. The goal is to study and understand the properties of diffuse galaxies: we will test our current theory according to which LSBs/UDGs arise from gas outflow episodes driven by supernovae feedback, which give rise to an expanded distribution of dark matter and stars. Searching for signatures of dark matter and stellar expansion in LSB galaxies is indeed a central theme of the proposed research, as we try to understand how LSBs arise in a galaxy formation context, which is currently an open issue. This is the first time that a joint theoretical and observational effort on LSBs is developed: ultimately, this will offer invaluable insights on the formation of such elusive galaxies and increase our understanding of the role of baryonic feedback in galaxy formation.

Keywords: low surface brightness galaxies,galaxy formation,dark matter,new techniques with optical telescopes
OPTimized conversion of residual wheat straw to bio-ISObutene for bio based CHEMicals (OPTISOCHEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Austria,Germany,Belgium,France,France,France
Call: Optimise technical production routes to bio-based chemicals in bio- or chemo-catalytic processes (H2020-BBI-JTI-2016, 2016)
Start date: 2017-06-01
End date: 2022-12-31
Duration (months): 67.0
Total project cost (EUR): 16376816.83
EU funding (EUR): 9755493.63
Participants: 7
Project status: SIGNED

OPTISOCHEM goal is to demonstrate the performances, reliability as well as environmental and socio-economic sustainability of the entire value chains, for the transformation of excess wheat straw into bio-Isobutene (bio-IBN) derivatives. To achieve these goals a team of 6 partners, leaders in their field, originating from 4 EU-member states, will join efforts. OPTISOCHEM consists in showcasing the technical accessibility and economical sustainability of the value chains, from wheat straw to 2 different families of chemicals derived from bio-based IBN. These compounds, oligomers (DIB, TIB, TeIB) and polyisobutylenes (PIBs) are currently used in a wide range of applications such as lubricants, adhesives, sealants, flavors & fragrances and substituted phenols. This large market is today supplied entirely by products derived from fossil-based isobutene. Products derived from bio-based IBN, using the same process as fossil-based IBN, and with at least as good performances, would provide a renewable supply. OPTISOCHEM includes the development & up-scaling of bio-IBN production from wheat straw, followed by the production and validation at relevant scale -representative of commercial, established processes- of the bio-based derivatives. To this end, four ambitious objectives were defined: -Demonstrate the production of wheat straw hydrolysate (WSH) and establish a quality standard to feed the IBN fermentation unit, -Demonstrate the production of bio-IBN from WSH at pre-commercial scale, -Demonstrate the quality of end products obtained with bio-IBN as a feedstock and using traditional commercial processes designed for fossil based IBN, -Determine and validate the targeted technical, economic as well as environmental/social sustainability performances to be achieved for a commercial plant project. Related Work packages, tasks, milestones and risks are considered in order to achieve these objectives. OPTISOCHEM project is fully aligned with the call topic.
From Contested Territories to alternatives of development: Learning from Latin America (CONTESTED_TERRITORY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Germany,Germany,Italy,Argentina,Spain,Germany,Germany,Bolivia, Plurinational State of,Colombia,France,France,Portugal,United Kingdom,United Kingdom,United Kingdom,Chile,Costa Rica
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-03-01
End date: 2025-12-31
Duration (months): 70.0
Total project cost (EUR): 2484000.0
EU funding (EUR): 2461000.0
Participants: 23
Project status: SIGNED

The overall objective of CONTESTED_TERRITORY is to form an international and intersectoral network of organisations from across Europe and Latin America on a joint research programme that pursues conceptual and empirical knowledge generation on innovative and sustainable bottom-up models of territorial development. We consider community-led practice enacting alternative knowledge as basis for a productive framework to grasp transformations of space and society supporting local-to-global knowledge diffusion. In particular, the RISE action will deliver novel understandings on how ordinary people produce innovative models for more sustainable and resilient environments. By this, we will learn how they shape, negotiate, imagine and collaboratively manage territories in contested and uneven power relations and how they progress models of social integration. The participants of the network will exchange and generate new knowledge to surpass mainstream understandings of development and contribute to scientific breakthroughs by integrating bottom-up strategies to adapt to risk, vulnerability and exclusion. Our progress will engage with and contribute to the UN Sustainable Development Agenda from alternative conceptual and practical perspectives. At the same time, we will nurture novel approaches to redefine the relations between humanity and the envi-ronment by including discourses emerging out of Latin American popular culture and indigenous cosmovision. This provides opportunities for academic and non-academic participants to actively shape practice and policies targeting more inclusive territorial development and different models of social cohesion. This will generate significant benefits for societies in Latin America, with transferable out-comes to Europe. Staff members participating in this action will develop new skills; be exposed to inspiring research environments, significantly widening their career perspectives in and beyond academia.

Keywords: urban geography,urban studies,displacement,extractivism,latin america,post colonialism,urbanisation,contestation,social movements
UPSCALING THE BENEFITS OF PUSH-PULL TECHNOLOGY FOR SUSTAINABLE AGRICULTURAL INTENSIFICATION IN EAST AFRICA (UPSCALE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Ethiopia,Germany,Germany,South Africa,Uganda,Germany,Switzerland,Switzerland,Sweden,Sweden,Tanzania, United Republic of,Serbia,Kenya,Rwanda
Call: Sustainable Intensification in Africa (H2020-SFS-2019-2, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 7655597.5
EU funding (EUR): 7655597.5
Participants: 19
Project status: SIGNED

Push-pull technology is a major discovery with high potential to increase food security and agricultural sustainability in East African smallholder farms. In project UPSCALE, we aim to scale up understanding and applicability of push-pull from individual fields to farm, landscape and regional scales, and from cereal to other crops and cultivation systems. By determining the factors influencing push-pull success across scales, we will enable targeted implementation and prediction of push-pull effectiveness and resilience under current and future climate conditions. Using novel remote sensing methods combined with simulation and empirical approaches, we will develop functional, chemical and sociocultural maps combined with environmental factors for spatial optimization of push-pull expansion at different scales. UPSCALE will test to what extent push-pull systems impact surrounding fields, farms, landscapes and regions, identifying potential feedbacks, non-linearities and socio-economic or ecological thresholds for adoption. Moreover, UPSCALE will explore the options to expand the use of push-pull for sustainable intensification in crops and systems outside cereal in synergy with other tools, and further intensify the system through incorporation of nutritious and high value crops. By harnessing the benefits of push-pull technology across scales and crops, UPSCALE will catalyse the design and widespread implementation of climate-smart and environmentally-friendly food production in East Africa and beyond.

Keywords: push pull technology,east africa,multiple scales,yields,dissemination,novel push pull crops
Development of a system for automatic ad insertion into on-demand streaming video to provide new monetization mechanisms to the media industry (TAPPXSSAI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the project is the creation of a Server Side Ad Insertion system for the media industry able to handle and insert Advertising content into streaming video. The system is based on an artificial intelligence able to analyse the original video content to create a series of metadata that allows the system to select the optimal Advertisement, as well as the optimal insertion moment, creating a targeted non-disruptive viewer experience. The transition of the media industry from traditional TV broadcasting to online content streaming requires this kind of new advertising insertion technology to allow the media industry to monetise the new type of content in the future. TAPPX's mobile advertising platform is currently handling over 400 Billion monthly requests for CPM advertising in mobile applications. The proposed development would handle a video advertising volume of a similar order of magnitude, which requires the development of methods for handling big data in a robust and functional system in real time.

Keywords: ad technology,streaming media,on demand video,programmatic advertising,ai driven video metadata
SmartGUIDE - Enabling a New Standard of Care Through a Smart Guidewire Device to Fight Stroke and Save Lives (SmartGUIDE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Each year, 15 million people suffer from stroke, resulting in 5 million deaths worldwide. This disease is treated via endovascular radio-guided surgery, where the guidewire used to navigate in arteries to reach a lesion is very difficult to orient and steer. At least 5 times per surgery, the surgeon has no choice but to remove the guidewire and reshape the tip by hand, a poorly controlled procedure. This results in increased infection and artery puncture risk for the patient, longer surgery duration (by 30 minutes) and higher costs. A total of 232’000 neuro-endovascular procedures are carried out in the US and EU to prevent and treat haemorrhagic and ischemic strokes. This represents a directly addressable market of €390M for SmartGUIDE. This market is a rapidly expanding sector with an estimated CAGR of 8.6% (2016 – 2021). Artiria Medical is a Swiss Spin-off from the EPFL founded in 2017 with the vision to bring disruptive minimally invasive technologies to physicians in order to decrease Stroke mortality and improve the patient’s quality of life. Our first product SmartGUIDE, is the next generation guidewire which comprises a unique remotely-shapeable tip, developed in collaboration with renowned specialists in the field of interventional neuroradiology. This patented innovation allows the surgeon to deflect in real-time, using a manipulator handle, the device head while navigating through brain arteries, making it easy to use with no training required. SmartGUIDE thus saves 30 minutes per surgery. Saving time translates to a direct improvement of patient recovery. SmartGUIDE replaces on average 2 devices for each procedure, thus reducing the overall surgery cost by €1,200 and is fully compatible with existing endovascular devices. Artiria is expected to generate 35 new jobs, annual revenue of €29.32M and cummulative profit of €18.32 by the 5th year of commercialization with a ROI of 7.4. Breakeven will be achieved by the 3rd year of commercialization.

Keywords: neuro endovascular,bioengineering,medical technology,medtech,interventional radiology,good health and well being
Transnational Network of cooperation for WIDESPREAD NCPs (NCP_WIDE.NET)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Estonia,Israel,Germany,Spain,Italy,Cyprus,Serbia,Croatia,Hungary,Romania,Slovakia,Slovenia,North Macedonia,Greece,Poland,Latvia,Czechia,Luxembourg,Portugal,Portugal
Call: Transnational network of national contact points (NCP) (H2020-WIDESPREAD-2014-3, 2014)
Start date: 2015-01-01
End date: 2021-06-30
Duration (months): 78.0
Total project cost (EUR): 1999521.0
EU funding (EUR): 1999521.0
Participants: 24
Project status: CLOSED

The objective of the NCP_WIDE.NET is to create a transnational network of National Contact Points (NCPs) for Spreading Excellence and Widening Participation under Horizon 2020 in order to facilitate trans-national co-operation between NCPs, with a view to identifying and sharing good practices and raising the general standards of support to applicants, taking into account the diversity of actors, including newcomers, that make up the constituency of WIDESPREAD part. Project is targeted towards the Widespread NCP Forum - officially nominated WIDESPREAD NCPs in EU Member States and Associated Countries - including experienced and less experienced NCPs. Expected impacts of the proposal aiming at ensuring quality standards of services, lowering entry barriers and increased applications to Horizon 2020 will be reached through a portfolio of dedicated meassures. The overall logic of the proposal is based on the improving and leveling of the NCPs capacities to deliver services of high quality standards, enhancing transnational collaboration between applicants, delivering complex information on WIDESPREAD activities and promoting the Network itself. The implementation of the proposal includes following tailored actions: internal trainings and mentoring based on benchmarking, support to WIDESPREAD expertise through development of guides and reports, transnational collaborative events for stakeholders such s brokerage events and joint workshops, actions dedicated to newcomers, networking activates, dissemination actions, complex source of information (Project Portal one-stop-shop) and promotion activities. Proposal addresses the work programme in terms of supporting and leveling NCPs capacity in delivering services of high quality standards. The project will contribute to more balanced development of ERA, spreading of excellence in research in all European regions and widening participation of research centers and stakeholders from weaker regions in H2020.

Keywords: national contact points,network,spreading excellence and widening participation,capacity building,trans national collboration,quality standars,dissemination,newcomers,lowering entry barriers
Nanoscale Systems for Optical Quantum Technologies (NanOQTech)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Sweden,France,France,Denmark
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 3378428.75
EU funding (EUR): 3378428.75
Participants: 8
Project status: CLOSED

Optical quantum technologies use light as a carrier of quantum information or to probe and control other quantum systems. They offer transformational advances in ultra-secure communication, sensing that surpasses classical limits, simulation of quantum systems and computation. To meet the high demands of these applications, systems with multiple quantum degrees of freedom that can be addressed by light and coupled to other quantum systems in hybrid architectures are strongly needed. However, current solid-state devices, which are highly desirable for technological development, do not fulfill these requirements. The goal of NanOQTech is to build nanoscale hybrid quantum devices that strongly couple to light. To achieve this breakthrough, we will create solid-state nanostructures that exploit the uniquely narrow optical transitions of rare earth ions. Our objectives are to develop RE nanostructures with long optical and spin coherences; couple these structures to optical micro-cavities to demonstrate single-ion optical quantum memories, two-qubit gates and deterministic narrowband single photon sources at 1.5 µm; build hybrid RE-graphene devices to achieve plasmon mediated ion-ion interactions; fabricate hybrid RE nano-resonators to reach the strong coupling regime; guide the experimental effort and prepare further advances by developing comprehensive theoretical tools. The project gathers 9 leading experimental and theoretical European teams in inorganic chemistry, solid-state and atomic physics, quantum optics and information processing, nano-electronics and photonics and nano-mechanics. including a young industrial start-up specialized in real-time signal processing and control. Within a three-year research project, we propose to develop materials and explore functionalities to establish RE nanostructures as a radically new platform that will broadly impact research and technology in quantum communications, information processing and sensing.

Keywords: rare earth,hybrid systems,nano resonators,graphene,quantum memory