Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart multifunctional GLA-nanoformulation for Fabry disease (Smart-4-Fabry)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Spain,Israel,Austria,Spain,Spain,Denmark,United Kingdom
Call: Nanoformulation of biologicals (H2020-NMBP-2016-two-stage, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 5844508.63
EU funding (EUR): 5844508.63
Participants: 14
Project status: CLOSED

Lysosomal storage disorders (LSD) diseases are a group of rare diseases that currently lack a definitive cure. LSD incidence is about 1:5,000 - 1:10,000, representing a serious global health problem. In the case of Fabry LSD Disease (FD), the deficiency in α-Galactosidase A (GLA) enzyme activity results in the cellular accumulation of neutral glycosphingolipids, leading to widespread vasculopathy with particular detriment to the kidneys, heart and nervous system. The current treatment for FD is the Enzyme Replacement Therapy (ERT), in which free GLA recombinant protein is administered intravenously to patients. ERT exhibits several drawbacks mainly related to the instability, high immunogenicity and low efficacy of the exogenously administered GLA to cross biological barriers, such as cell membranes and BBB.The aim of Samrt-4-Fabry project is to achieve excellent quality control over the assembly of the different molecular components of a new liposomal nanoformulation of GLA, nano-GLA, for the treatment of Fabry disease. Nanoformulated GLA has already shown to have better PK/PD profile than free GLA and higher efficacy in vivo. Smart-4-Fabry project will advance nano-GLA from an experimental PoC (TRL3) to preclinical regulatory phase (TRL5-6). A one-step method based on the use of green cCO2, will be used for the manufacturing of this novel nanoformulation under GMPs. The final GLA nanoformulation will have tailored transport of GLA through cell membranes and BBB. Fulfillment of Smart-4-Fabry will impact on a major health problem, the existence of new therapies for rare diseases, which constitutes a priority societal challenge as shown in the H2020 Work Programmes. Another important impact is related to its contribution to support the European Strategy for KETs, which aims to reverse the decline in manufacturing as this will stimulate growth and jobs. Smart-4-Fabry is strongly focusing on three KETs: nanotechnology, industrial biotechnology and advanced materials.

Keywords: gla delivery,liposomal nanocarrier,lipid self assembly control,fabry disease,gmp green manufacturing process,cellular membrane penetration,blood brain barrier crossing,peptide targeting
From Geometry to Motion: inverse modeling of complex mechanical structures (GEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2022-02-28
Duration (months): 78.0
Total project cost (EUR): 1498570.0
EU funding (EUR): 1498570.0
Participants: 1
Project status: CLOSED

With the considerable advance of automatic image-based capture in Computer Vision and Computer Graphics these latest years, it becomes now affordable to acquire quickly and precisely the full 3D geometry of many mechanical objects featuring intricate shapes. Yet, while more and more geometrical data get collected and shared among the communities, there is currently very little study about how to infer the underlying mechanical properties of the captured objects merely from their geometrical configurations. The GEM challenge consists in developing a non-invasive method for inferring the mechanical properties of complex objects from a minimal set of geometrical poses, in order to predict their dynamics. In contrast to classical inverse reconstruction methods, my proposal is built upon the claim that 1/ the mere geometrical shape of physical objects reveals a lot about their underlying mechanical properties and 2/ this property can be fully leveraged for a wide range of objects featuring rich geometrical configurations, such as slender structures subject to frictional contact (e.g., folded cloth or twined filaments). To achieve this goal, we shall develop an original inverse modeling strategy based upon a/ the design of reduced and high-order discrete models for slender mechanical structures including rods, plates and shells, b/ a compact and well-posed mathematical formulation of our nonsmooth inverse problems, both in the static and dynamic cases, c/ the design of robust and efficient numerical tools for solving such complex problems, and d/ a thorough experimental validation of our methods relying on the most recent capturing tools. In addition to significant advances in fast image-based measurement of diverse mechanical materials stemming from physics, biology, or manufacturing, this research is expected in the long run to ease considerably the design of physically realistic virtual worlds, as well as to boost the creation of dynamic human doubles.

Keywords: inverse modelling,nonsmooth mechanics,frictional contact,dynamics of slender structures,physically guided shape reconstruction
EMPowering Heterogeneous Aviation through cellular SIgnalS (EMPHASIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Germany,Finland,Czechia,Czechia
Call: Enabling Aviation Infrastructure: CNS for General Aviation (H2020-SESAR-2016-2, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 937130.0
EU funding (EUR): 937130.0
Participants: 5
Project status: CLOSED

The key objective of the project EMPHASIS (EMPowering Heterogenuous Aviation through cellular SIgnalS) is to increase safety, reliability and interoperability of General Aviation/Rotorcrafts (GA/R) operations both with commercial aviation and with emerging drones operations. These aspects are foreseen as critical elements to secure and improve airspace access for GA/R users in future airspace environment and improve operational safety of their operations. This objective is planned to be achieved through affordable CNS capabilities tailored for GA/R users where the envisioned path to reduce avionics costs is driven by: 1. Deep analysis of Communication, Navigation and Surveillance system requirements (including reliability and integrity) based on the specificities of GA/R operations. The analysis should allow to identify requirements critical for operational safety and potentially lower requirements with limited applicability to GA/R operations. 2. Optimal combining of ground and airborne technologies enabled through advanced communication means. 3. Innovative approach to certification allowing to achieve overall safety objectives with reduced impact on the cost. The most promising technologies (combining both on-board and ground elements) will be developed up to the proof-of-concept maturity level.

Keywords: general aviation,rotorcraft,certification
Cost-effective PROton Exchange MEmbrane WaTer Electrolyser for Efficient and Sustainable Power-to-H2 Technology (PROMET-H2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Italy,Germany,Germany,Germany,Germany,Belgium,Norway,Greece
Call: Materials for non-battery based energy storage (RIA) (H2020-NMBP-ST-IND-2019, 2019)
Start date: 2020-04-01
End date: 2024-03-31
Duration (months): 48.0
Total project cost (EUR): 5900250.0
EU funding (EUR): 5900250.0
Participants: 12
Project status: SIGNED

The need for de-carbonization of our society is a pressing issue raising the attention at social and political levels. The production of high value chemicals and fuels such as methanol requires hydrogen derived at the moment from hydrocarbons and resulting in large emissions of CO2. Green Hydrogen produced by water electrolysis coupled to renewable sources could be the ultimate solution to this problem. Proton exchange membrane water electrolysis (PEMWE) is the most suitable technology for this process due to its compactness and flexibility. However, the dependence on precious metal catalysts and expensive components manufactured in titanium poses a serious threat for the scale up and market penetration of this technology. PROMET-H2 project aims to develop a pressurized PEMWE with the lowest capital cost ever achieved (500-750 €/kW) without compromising performance and durability. The stack, based on hydraulic compression technology, will contain improved membranes and electrodes with reduced or even free of precious metal contents and with coated stainless steel bipolar plates (BPP) and porous transport layers (PTL). The materials and components that will make this possible have already been demonstrated in laboratory and in PROMET-H2 these innovations will be implemented in a 25 kW PEMWE system. Such electrolyser will be coupled with a methanol production pilot plant from CO2. Materials recycling strategies will be developed and a deep LCA and cost evaluation will be realised to ensure that the new PEMWE can be scaled-up to meet the demands of large methanol industrial plants. A well-balanced consortium of 12 industry and academic partners will address these challenges in three years with the aim of achieving renewable methanol production. At the end of the project, they will establish R&D and business cooperation in a value chain that goes from the nanomaterial synthesis to the green production of one of the most promising fuels and feed-stock chemicals.

Keywords: power to hydrogen,proton exchange membrane water electrolyser,crm free,electrocatalysts,membrane,bipolar plates,porous transport layers,power to methanol,pemwe stack
Activity Based System Reliability Evaluation Flow (ABSREF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

This proposal envisions to foretell the reliability of electronic systems with high degree of accuracy by introducing a novel workload dependent aging aware simulation framework which has acceptable run-time. The framework is generic in nature and will enable one to perform system optimization in presence of multiple aging related phenomena including negative bias temperature instability, positive bias temperature instability, and hot carrier injection. Thus the benefits of the improved timing margin or guard-band incurred by this flow can be leveraged to further improve speed, power, durability of electronic systems and reduce cost. An efficient workload abstraction scheme will be employed which speeds up the transistor level degradation evaluation with accuracy comparable to that of cycle-accurate simulations. Using the device level degradation results, standard cell library characterization will be performed by statistical methods based on Design of Experiments and Response surface Modelling approach. The created workload dependent, aging aware cell libraries will be used to carry out static timing analysis and optimization. Critical path delay degradation evaluated under this framework will be compared with the corner based aging analysis to highlight the impact of the innovation. The framework will be validated using industry standardized, CPU intensive SPEC2006 benchmark suite run on top of multi-core industrial processor. Considering its interdisciplinary nature, the project will help bridge the gap between two disciplines: the device level reliability research and system level interactions. Working in highly international and intersectoral environment of the host IMEC, Dr. Mishra will enhance his professional skills to become a mature independent researcher.

Keywords: electronic systems reliability modeling
Terahertz sensors and networks for next generation smart automotive electronic systems (Car2TERA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Spain,Sweden,Sweden,Poland,Poland
Call: Electronic Smart Systems (ESS) (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2023-03-31
Duration (months): 51.0
Total project cost (EUR): 3999688.75
EU funding (EUR): 3999688.75
Participants: 10
Project status: SIGNED

The objective of Car2TERA is to develop emerging sub-THz (150-330 GHz) smart electronic systems based on latest semiconductor, microsystem and nanoelectronics technologies, and to implement TRL-4 demonstrators in two high-potential application scenarios: (1) a new class of compact, high-resolution, electronic-beam-steering short-range car radar sensors, with the primary application being in-cabin passenger monitoring (currently fastest growing car sensor market) for individually and real-time adjusted crash mitigation measures; (2) short-distance, high data-rate THz-over-plastic data links for telecommunication radio-access and backbone networks facilitating the data growth demanded by 5G and IoT. Car2TERA combines, for the first time, the results of recent achievements in semiconductor, micro- and nanoelectronics scientific projects, including the Graphene Flagship, an ERC and several EU collaboration projects, with the following emerging THz technologies: (1) 600-GHz-fmax SiGe monolithic-microwave integrated circuits (MMICs); (2) silicon micromachining for system integration, packaging and phased-array antenna front-end; (3) integrated MEMS reconfigurability; and (4) large-bandwidth, high-linearity graphene MMICs; (4) advanced signal processing including OFDM radar signals and AI sensor fusion. The consortium: Veoneer, world’s largest car safety equipment manufacturer; Ericsson, world leading in telecommunication systems; Infineon, world’s largest manufacturer of SiGe radar chip sets; the academic partners Chalmers and KTH, leading in MMIC design and micromachining/THz MEMS; and three SMEs leading in sub-THz technologies and 2D-materials. With European car module manufacturers holding a market share of 79% on car radars, and European semiconductor manufacturers 90% on SiGe car-radar chip sets, this project aims at extending Europe’s success story on advanced, smart electronic sensor systems into the sub-THz frequency spectrum and into new emerging applications.

Keywords: terahertz,sensor systems,adas,autonomous vehicles,silicon germanium,sige,sub thz frequency bands,car radar,micromachining,mems,mmic
Using a natural cellular plasticity event to decypher the cellular requirements and molecular circuitry promoting transdifferentiation at the single cell level. (PlastiCell)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

How differentiated cells can change their identity is a fascinating question. Indeed, natural interconversions between functionally distinct somatic cell types (aka transdifferentiation, Td) have been reported in species as diverse as jellyfish and mice, while experimentally induced reprogramming of differentiated cells has been demonstrated. The relative ease with which cellular identities can be reprogrammed raises a number of exciting questions: What mechanisms and steps allow a given cell, but not its apparently identical neighbours, to naturally acquire a new plasticity potential and change its identity? How does the cellular context influence the ability of a cell to be reprogrammed? What cellular mechanisms must be counteracted to allow natural reprograming to occur? What circuitry underlie the impressive efficiency observed in natural events? The proposed project tackles these questions To systematically identify the molecular networks and cellular requirements of Td, we established a simple model of natural Td, in C. elegans, where the conversion of a rectal cell into a motoneuron is followed in vivo. This model is unique: it is 100% efficient, predictable and provides the first unambiguous demonstration, at the single cell level, of natural Td. The study of such natural event has revealed a key asset to unravel the discrete steps of the process, their control and the conserved cell plasticity factors promoting its initiation, while leading to important concepts conserved across phyla. We propose here 4 aims to push new frontiers and: i) Define what makes a cellular context permissive; ii) Elucidate the conserved nuclear complexes and network architecture promoting efficient reprogramming; iii) Identify mechanisms that protect the differentiated identity and act as a brake to Td. Understanding cell plasticity in vivo will have a tremendous impact on our perception of developmental and cancerous processes and could open new avenues for regenerative medicine.

Keywords: c elegans,transdifferentiation,natural direct reprogramming,node,rectum
Mach-Zehnder and Interference Get Enhanced by Reinforcement Learning (MAZINGER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2024-03-01
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: SIGNED

Photonic integrated technologies provide an outstanding platform for several areas of research, from fundamental tests of quantum mechanics to quantum simulation and quantum communication. Recently, mid-scale circuits have already been applied to various tasks, most notably to realize quantum walks or Boson Sampling experiments. The potential of these technologies to reach large-scale implementations is rooted in the unique features of single photons, such as mobility, high bandwidth and ease of manipulation. In this direction, major obstacles are represented by the availability of sources and detectors with limited efficiency, as well as by an imperfect control over their reconfigurable optical evolutions. However, while practical solutions can be engineered for the two former stages, the latter opens up a challenge when compact and dense integration is desired for high-precision tasks. The research project MAZINGER will take up this challenge by bringing together analytical and numerical tools, in order to enhance single-photon evolutions in state-of-the-art photonic applications. To this end, MAZINGER will employ well-established tools from machine learning, such as reinforcement learning algorithms and saliency maps, to cope with changing environments and non-ideal reconfigurable components, respectively. To strengthen our research, the project involves a collaboration with a leading group in experimental photonics, with the goal of testing out and applying our findings on a high-precision test of quantum mechanics. In particular, the employed numerical techniques will be solidly based on the general framework of multi-photon interference, which has been investigated, both theoretically and experimentally, by the key players of this project. Eventually, MAZINGER will pave the way for self-optimized applications of single- and multi-photon quantum interference in integrated photonic circuits.

Keywords: multi photon quantum interference,integrated quantum photonics,machine learning
Regulating the immune regulators: targeting adaptive immune control (REGiREG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1955000.0
EU funding (EUR): 1522376.36
Participants: 2
Project status: CLOSED

The immune system with its complex interactions of cells and molecules needs a very tight and specific interplay of control elements to ensure the establishment and re-establishment of immune homeostasis after challenges. Regulatory T cells (Tregs) are key-players in this regulatory network. It is now well accepted that deficiency or dysfunction of Tregs causes various severe immune disorders due to immune hyperactivation. Conversely, an increased number of Tregs in tumor-bearing individuals suppresses efficient anti-tumor immunity and, thereby, is often associated with poor prognosis. Cancer immunology is now one of the most exciting and promising frontiers in cancer research, and recent clinical trials have proven that immunotherapies driving to activate T cells can induce durable responses. In this sense, harnessing the potential of Tregs is one of the most promising new approaches to control immune function and to treat cancer. This proposal has two objectives: 1, the identification and characterization of tissue-resident Tregs to principally understand the unique features of Treg specialization in tissues and their function in organ-homeostasis, a phenomenon that is hardly understood, but holds great promise for local, tissue-specific immune intervention. 2, to globally target Tregs, including the lymphoid organ Treg pool, by interfering with their survival and or suppression function. We expect from these studies new basic insights into a fascinating and still arcane aspect of organ-homeostasis as maintained by Tregs, as well as novel small molecule inhibitors and candidate molecules that target Tregs at the systemic level, and eventually at a tissue-specific level.

Keywords: regulatory t cells,immune regulation,foxp3,tolerance