Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EPIGENETIC MARKERS OF DISEASE STATUS AND REVERSAL FOR PERSONALIZED MANAGEMENT OF OBESITY AND DIABETES (OBEDIA-MARK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-20
End date: 2019-06-19
Duration (months): 36.0
Total project cost (EUR): 243208.8
EU funding (EUR): 243208.8
Participants: 2
Project status: CLOSED

Epigenetic marks such as DNA methylation (DNAm) can store cell memories of past life experiences. Thanks to this property, these marks hold great potential as biomarkers for personalized management of diseases arising from gene-environment interactions such as obesity and associated disorders. However, realizing this potential requires large-scale longitudinal studies that evaluate epigenetic markers under consideration of pertinent lifestyle and genetic factors. The goal of the proposed project is to fill this research gap by identifying, for the first time in a large-scale longitudinal study, epigenetic biomarkers of disease status and reversal for personalized management of obesity and diabetes. To attain this goal I will i) Identify overweight -associated DNAm markers by comparing DNAm patterns of 400 obese subjects before and after a randomized controlled weight-loss intervention, ii) Assess the relationship of the identified markers with gene-diet interactions, and their reversibility in response to weight-loss, iii) Test the validity of these markers, alone and in combination with genetic analysis, as biomarkers for prediction of weight-loss performance and diabetes status/reversal. Expected outcomes: I) Drive innovation in personalized medicine by identifying epigenetic markers of disease status and reversal in obesity and diabetes, ii) Expand our understanding of how epigenetic, genetic and dietary factors interact with each other in the development and reversal of obesity, iii) Equip me with the knowledge and skills needed to become an independent scientist. The quality of the research, hosting arrangements and collaborations will provide me with the best opportunities to expand my expertise in epigenetics, apply it to research on human disease, and reinforce my professional maturity for securing a faculty position in Europe.

Keywords: dna methylation,epigenetic biomarkers,obesity,type 2 diabetes,personalized medicine
Monumental Art of the Christian and Early Islamic East: Cultural Identities and Classical Heritage (HERITAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2020-07-31
Duration (months): 47.0
Total project cost (EUR): 1272894.01
EU funding (EUR): 1272894.01
Participants: 1
Project status: CLOSED

This project will analyse the monumental art (large decorative programmes on buildings) of two areas of the former eastern Roman Empire which came under Islamic rule but which have never been the subject of an integrated comprehensive study: Egypt and Syro-Palestine (modern Syria, Jordan, Lebanon, and Israel/Palestine). It aims to determine systematically how the strength and nature of the local ‘classical’ (Greco-Roman) traditions and expressions of identities influenced monumental art in these regions during Late Antiquity (AD 250–750), the period of transition from paganism to Christianity and, in turn, to Islam. By defining and distinguishing between the different strands of classical influence, both local and external (from the centres of Rome, Constantinople, and Alexandria), and investigating the roles of local artists and artisans as creators rather than imitators, this project will transform our understanding of the artistic culture of the late antique Middle East. To achieve these objectives, this 5-year project, with a team of 4 post-docs, will apply an interdisciplinary methodology, using archaeology, architecture, art history, and textual analysis to examine evidence in a range of media (floor and wall mosaics, paintings, relief sculptures). The results will be presented in a synthetic analytical volume written by the PI and two books on late antique and early Islamic mosaics by the post-docs, with material placed on the Manar al-Athar open-access website. Monumental art is the most visible surviving artistic heritage in the Middle East, on major buildings such as the Dome of the Rock in Jerusalem, the Great Mosque in Damascus, ‘desert castles’, and church mosaic floors. This art is increasingly endangered, so it is essential to undertake this project now to show the importance of this art, the roles of ancestors of peoples of the Middle East in its creation, and the shared classical heritage of the Middle East and the West.
Next generation online payments and fraud detection API for European SMEs (PAYPLUG LABS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-06-01
End date: 2017-12-31
Duration (months): 31.0
Total project cost (EUR): 2977725.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: CLOSED

The European e-commerce market is growing fast, but the complexity of setting up online payments and the concerns about credit card fraud still represent significant barriers that prevent many SMEs from trading online. Indeed, the EU’s target for 33% of SMEs to be selling online by 2015 is far from being met (only 14% in 2013). PayPlug Labs aims to offer SMEs a next generation payment system that will reduce software integration costs thanks to a state-of-the-art REST API, and provide low-touch fraud protection thanks to modern statistical algorithms and machine learning. The project fills the gap between traditional online payment solutions, that require expensive integration efforts, and e-wallet solutions. Additionally, existing fraud detection systems are commercialised separately and rely on dated “rule-based” technologies implying prohibitive set up costs for SMEs. The project will be led by PayPlug, a company created in 2012 that has developed an easy-to-install online payment “plugin” for micro-enterprises. The company is composed of a talented management team with a strong background (Google, Harvard, Polytechnique), and a high-profile advisory board. The company has attracted 1.4M€ of private investment and employs 10 full-time employees.

Keywords: online payments,fraud detection,e commerce,rest api
Swimming asleep: characterization, ontogenesis and energetic basis of sleep during paddling in waterfowl (SLEEPSWIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Although sleep has been found in most animals, our understanding of its function remains limited. A longstanding theory proposed that sleep has energy saving functions. Thus, an individual is expected to engage in sleep more often when energy intake is much lower than its energy demand. However, while facing such a negative energy balance, there might be some ecological contexts within which the need for sleep may conflict with the need for being awake. To overcome this issue, some species can display a mixed state wherein one cerebral hemisphere is asleep and the other is awake. Other than its importance as anti-predatory strategy, this phenomenon has received attention because it is the only sleep type that is compatible with locomotion, as shown in dolphins. However, in birds the possibility of combining sleep and active locomotion has never been demonstrated. In my recent observations, I obseved several goose species paddling while keeping their eyelids closed, which is a typical feature of sleep. The general aims of my project are to describe, for the first time in birds, the simultaneous occurrence of sleep and stereotype locomotion and to investigate how energy balance affects this phenomenon. Using the graylag goose (Anser anser) and state-of-the-art neurophysiological recording methods, I will describe whether eye closure during paddling is actually associated with sleep and if it occurs uni- or bihemispherically. Then, I will test whether the expression of this phenomenon varies during early-life development. Finally, I will study the modulation of such behavior in response to a gradient of energy requirement. My findings will not only be fundamental for uncovering the existence of sleep during active locomotion in birds, as well as factors driving its occurrence, but they will also propose the use of sleepswimming in geese as a model for investigating sleepwalking in humans, a poorly understood and, in some cases, life-threatening disorder.

Keywords: electroencephalogram,active locomotion,swim,birds,geese,energy management,brain activity,stereotyped movements,growth
Multicomponent Aerogels with Tailored Nano-, Micro- Macrostructure (MAEROSTRUC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 1499769.0
EU funding (EUR): 1499769.0
Participants: 1
Project status: CLOSED

Aerogels and hydrogels from nanocrystal building blocks are a fascinating novel class of materials with extremely low densities and large specific surfaces, which partially exhibit the advantageous properties of their nanoscopic building blocks (e.g. size quantized fluorescence or catalytic activity). In the present project, multicomponent gels with controlled mechanical properties, plasmon enhanced fluorescence, photocatalytic properties, and with controlled conductivity properties will be synthesized. These new materials will not only exhibit the nanoscopic properties of their building blocks, but they will also exhibit new properties which are neither accessible from nanoparticle nor from bulk material. This will e.g. be achieved due to nanoscopic interactions between the materials or due to synergistic combination effects caused by appropriate material combination. Synthetic routes for nanostructuring, microstructuring and macrostructuring nanocrystal hydrogels and aerogels will be developed. Nanostructuring involves advancement of colloidal nanocrystal synthesis as well as postsynthetic gel modifications. Microstructuring involves synthesizing multicomponent gels with defined contact points of the materials and intercalating multicomponent gels. Macrostructuring involves implementation of the gelation techniques into 3D printing, and gel deformation by external triggers and will enhance the applicability of gels. The materials developed will be tailored for several physicochemical effects and hence applications. While the project focuses on the synthesis of these new materials with defined physicochemical properties, the outcome of this project will influence many different research and application fields, such as electrodes and batteries, sensors, photocatalysis and catalysis, solar cells, air and solar batteries, and even membranes and touch screen devices.

Keywords: aerogels from nanocrystal building blocks
Feasibility study of a novel treatment for cancer based on a recombinant peptide therapy (PEPTO1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Spain
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Peptomyc S.L. is an SME created to develop a new, first-in-class, cancer therapy using innovative anti-Myc peptides. Myc is an oncogene deregulated in the majority of human cancers, making Peptomyc’s products potentially applicable to all cancer patients. The recombinant peptides are based on Omomyc, a Myc inhibitor benefiting from 20 years of preclinical validation as gene therapy. Omomyc displays remarkable therapeutic impact in multiple cancer models, with limited side effects, and no emergence of resistance. These peptides (Omomyc-CPP) developed by Peptomyc have unexpected cell-penetrating properties that make them excellent candidates for drug development. Three different drug products are being derived from the same drug substance, based on different administration routes, formulations and delivery devices. Peptomyc’s first mission is to take the first drug product (OMO-101) to completion of a successful phase I/II clinical trial, demonstrating safety and efficacy initially in glioblastoma (GBM) patients. Upon completion of phase I/II, Peptomyc plans to reach a licensing deal with a pharmaceutical company, to take care of further development and commercialization of OMO-101. In the feasibility study proposed here, Peptomyc’s team will elaborate and refine the business development plan of this new therapy to maximize its social and commercial potential. Such study will include: a. Management of the IPR strategy; b. Selection of the best CRO partners for [1] execution of safety studies, [2] clinical trials coordination, [3] Pre-IND and IND applications and other regulatory requirements; c. EMA Briefing meeting; d. Refinement of the business development plan, including market and risk analyses and costs. This feasibility study will be a strong asset to advance this unique, innovative therapy towards its commercialization not only in GBM, but eventually in multiple cancer markets.

Keywords: peptomyc,viability,cancer therapy,de risking,feasibility study
Development of Effective Vaccines against Multiple Lifecycle Stages of Plasmodium vivax malaria (MultiViVax)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Sweden,France,France,United States,United Kingdom,United Kingdom,Denmark,United Kingdom
Call: Vaccine development for malaria and/or neglected infectious diseases (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 5736576.25
EU funding (EUR): 5058974.0
Participants: 10
Project status: SIGNED

Plasmodium vivax is the most widespread malaria and constitutes a significant proportion of human malaria cases. P. vivax accounts for 100-400 million clinical cases each year among the 2.5 billion people living at risk in Latin America, Oceania and Asia. The recently revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria and calls for a vaccine intervention to achieve 75% efficacy over two years – equally weighted with P. falciparum. However, despite this global health need, efforts to develop interventions against this parasite have lagged far behind those for P. falciparum, in large part because of critical bottlenecks in the vaccine development process. These include i) lack of assays to prioritise and down-select new vaccines due to lack of an in vitro P. vivax long-term culture system, and ii) lack of easy access to a safe controlled human malaria infection (CHMI) model to provide an early indication of vaccine efficacy in humans. The Objectives of this MultiViVax proposal will address these critical bottlenecks and shift the “risk curve” in order to better select successful vaccine candidates against multiple lifecycle stages of P. vivax: 1. We will establish a P. vivax CHMI model in Europe for the first time to facilitate the better selection of effective vaccines and remove the current bottleneck for their early-phase clinical testing. 2. We will utilise this CHMI model to identify novel antigens associated with protective blood-stage immunity in humans by taking advantage of recent advances in immuno-screening and parasite RNASeq. 3. We will progress existing vaccines targeting the current leading antigens for both the blood- and transmission-stages along the clinical development pipeline. 4. We will develop novel transgenic parasites for use in assays in order to overcome the current bottleneck in vaccine down-selection caused by the inability to culture P. vivax parasites.

Keywords: vivax
Re-Mapping the Numerical Brain. (Re-MAPMATH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-07-01
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Little is known on how the math system overcomes selective damage to parts of its brain bases. Indeed, brain adaptation has been observed in other domains, such as language: the loss of key language-related areas very often leads to brain reconfiguration for an ultimate successful behavior. Functional redundancies and remapping become visible in brain tumor patients for whom the slow growth of a tumor allows for functional reorganization. Re-MAPMATH aims the tracking of plastic brain changes behind math functions before and after surgery in brain tumor patients. For this, we will use neuroimaging techniques that allow for an optimal spatiotemporal resolution, entailing an advanced approach in the field of math cognition. The project main objectives are: (1) to precisely describe the brain bases for different math processes in the normal population, including functional activations and functional connectivity (2) to track how these default activations, functional and structural connectivity are modified by the growth of a tumor and (3) by the resection of the tumor, measuring three months after surgery. Finally (4), we aim the detection of commonalities across patients with the goal of describing redundancies and alternative pathways that allow a successful numerical behavior. In turn, uncovering these alternative neurofunctional systems can ultimately explain compensation in math disorders, as well as provide with useful information for the rehabilitation of essential math functions after surgery.

Keywords: numerical cognition,brain reorganization
Transport: Advanced and Modular (TrAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Germany,Germany,Norway,Norway,Greece,Norway,Norway,Belgium,Belgium,Netherlands,United Kingdom,United Kingdom
Call: Complex and value-added specialised vessels (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-09-01
End date: 2023-02-28
Duration (months): 54.0
Total project cost (EUR): 14662856.31
EU funding (EUR): 11741430.63
Participants: 17
Project status: SIGNED

The project will develop and validate a concept for modular design and production of vessels. We combine advantages of scale and standardisation with customisation options, allowing small-series and one-off vessel construction, using interchangeable modules across vessel types. Even though parts of our work will have a wider relevance, we focus on inshore vessels (operating coastal areas and inland waterways) with electric power systems. The project is divided in three phases: Specification, innovation, and replication. In the specification phase, we perform a wide meta-analysis of both user needs and existing technological solutions, coupled with case-studies of needs and technologies for four targeted use cases. In the innovation phase, we develop the modular design concept; combining theoretical approaches, cross-fertilisation of methods from other industries (mostly rail and automotive), deep maritime experience in the relevant areas (including hull design, propulsion and electric power systems) and heavy involvement by operators (including three as consortium partners). The concept is applied to, and refined through, four demonstrators: Two ferries, a workboat and a vessel for goods traffic on inland waterways. At least one of the demonstrators will be physically built, co-financed by Rogaland County Council and its transport subsidiary Kolumbus, and used to operate a multi-stop commuter route into Stavanger. It will be a fully electric fast passenger ferry, operating in a region that is a substantial exporter of hydropower. In the replication phase, we will further validate the concept through five additional demonstrators (planning and simulation level) together with operators that did not participate in the details of the first two phases. Our aim is that the modular concept will prove to work as a general purpose toolkit within our market segment, proving that a wide set of vessel types can built in a cost-efficient and environmentally friendly manner.

Keywords: modular design,inshore vessels