Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advancing Lactobacillus’ beneficial potential (Lacto-Be)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1499581.0
EU funding (EUR): 1499581.0
Participants: 1
Project status: SIGNED

Lactobacillus bacteria have a strong, but underexplored potential as sustainable bio-based solutions for many food and health-related problems. Since Nobel-laureate Eli Metchnikoff hypothesized that lactic acid bacteria can promote human health in the gut, the research on lactobacilli and probiotics has mainly focused on the human gut and fermented dairy foods. However, a major knowledge gap exists on the beneficial potential of Lactobacillus species in other human body sites (vagina, skin, upper respiratory tract), animals (e.g. chickens, honey bees), plants, crops, and even on abiotic surfaces. In addition, lactobacilli play a key role in many plant- and vegetable-based fermentations, where they promote the shelf life and nutritional value of food and feed. Yet, why and how Lactobacillus species can be beneficial in such a wide variety of niches is currently underexplored. Therefore, the core aim of this project is a systematic and integrated analysis of the evolutionary history, ecology, and beneficial functions of Lactobacillus species. I propose an unconventional approach situated at the intersections of molecular microbiology (focusing on a single microbe), molecular ecology (focusing on microbial communities) and comparative genomics with an evolutionary perspective on niche adaptation of lactobacilli. By looking deeper into Lactobacillus biology, a paradigm shift can be made moving from a classical ad hoc base to a unique knowledge-based framework for strain selection and analysis of fitness and performance.

Keywords: probiotics,mode of action,evolutionary history,niche adaptation,niche flexibility,bacteria host interactions,exopolysacchariden,non ribosomal peptide synthetases
Efficient Aluminium Salt cake Recycling Technology (AluSalt)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-2-2014, 2014)
Start date: 2015-09-01
End date: 2017-10-31
Duration (months): 26.0
Total project cost (EUR): 3509357.43
EU funding (EUR): 2456550.0
Participants: 1
Project status: CLOSED

Aluminium is the world’s second most used metal. During aluminium extraction and recycling, salt slag is generated in vast volume and is a growing environmental problem. In Europe there are >270 known aluminium processing plants and only nine salt slag recycling facilities, this number is restricted due to economic viability of operation; there are very high initial capital cost and high operating costs. These costs create a high entry barrier for any new company to enter into the salt recycling business. EU countries such as Scandinavia and Eastern Europe transport many thousands of tonnes of salt slag p.a. thousands of kilometres for processing at the few locations available at enormous financial and environmental cost. This is a threat to the aluminium production industry as costs to process salt slag are becoming extremely high. Due to the monopolisation of re-processing options, it is a financial security issue for the aluminium recyclers as they are in the hands of the nine salt slag recyclers in operation. This highlights an industry need for aluminium recycling companies to manage in house all of their by-products and waste materials economically. ALTEK is a technology-based company with specialist expertise and experience in aluminium technology. With EC FP7 funding support, ALTEK have developed to TRL 6, ALUSALT, an in-house salt slag processing unit that offers aluminium recycling plants an economic solution to salt slag processing, reducing energy process requirements, transport costs and CO2 emissions. ALUSALT offers the industry a solution that complies with EU legislation, reduces environmental impact and can achieve cost savings of €1.95m p.a. (based on a 10,000 tonnes p.a salt slag producer). It is envisaged ALUSALT will revolutionise the industry saving €33.15m and 19,550 tonnes of CO2 p.a. based on 6.23% EU market penetration. With EU funding support ALTEK will embark on a significant new growth strategy aligned to the company’s mission.

Keywords: aluminium,recycling,salt slag,processing,waste reduction,spray drying,leaching
Regeneration of Sinusoidal niches to preserve hematopoiesis after chemotherapy on Ageing (ReSinAge)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1997360.0
EU funding (EUR): 1997360.0
Participants: 1
Project status: SIGNED

Cancer is a disease of the elderly and chemotherapy remains the mainstay of treatment. The benefits of chemotherapy include increased overall survival, improvement in quality of life, and palliation of symptoms. However, older patients are more susceptible to specific toxicities of chemotherapy, like myelosuppression and life-threatening neutropenia. Among the tissues strongly affected by chemotherapy, the bone marrow sinusoidal endothelial cells constitute the most important supportive niche for aged hematopoietic stem cells function and for myelopoietic recovery in the elderly. Up to now, few data are available about how aged sinusoidal niches regenerate upon chemotherapy damage and whether it is possible to rejuvenate vascular endothelial stem cells and improve the regeneration of the old sinusoidal niche as an effective strategy to improve HSC function and prevent myelosuppression and life-threatening neutropenia in the elderly. Here I hypothesize that the reduced regenerative capacity of aged sinusoidal niches can be improved by rejuvenating vascular endothelial stem cells in vivo via targeting Cdc42 activity and the Notch:Jag2 signaling. The current proposal investigates whether improving the regeneration of the aged sinusoidal niche might represent an important target to enhance the hematopoietic recovery and increase the survival after chemotherapy in the elderly. By combining several ground-breaking approaches ranging from single-cell sequencing, whole-mount bone marrow imaging, deep learning strategies for data analysis and integration, stem cell sorting techniques and specific mouse models, this research project will demonstrate that aging is not irreversible and that targeting the stem cell niche could represent an unprecedented innovative strategy to improve the regenerative capacity not only of hematopoietic stem cells.

Keywords: stem cell niche,vascular endothelial stem cell,chemotherapy toxicity,aging,hematopoietic stem cell,cdc42,jag2
Sensing Anywhere IIoT Ultra-Energy Efficient (KUNAK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There are processes or situations in isolated environments, where there is no electricity or communications and autonomous energy systems are required that use batteries that last longer than 10 years. These processes are very difficult to monitor. These processes are also quite expensive to control in industrial environments that require very low power consumption. We have developed the comprehensive Kunak solution, a system to deploy IIoT solutions, whose ultra-energy efficiency characteristics provide great advantages in isolated and/or complex environments (Wireless Devices that operate in sleep mode most of the time), which makes it unique. Kunak is an end to end solution, that encompasses components from the hardware itself, embedded and encrypted software, to wireless communications and the platform on their own cloud (KunakCloud), receiving data communications management, sensors and equipment, with data display layer and API for web services. Clients can access information through it, export it, integrate it into existing systems, change remote settings, operate the equipment, apply big data and mass storage techniques, ensuring the interoperability of sensors, calibration, protocols and the model data with any existing system. The Kunak system facilitates the rapid deployment of IIoT solutions and allows clients to focus exclusively on the final application, and the exploitation and analysis of data. Kunak is a disruptive solution because we have developed a complete system, designed with the goal of achieving ultraefficient energy in the design of each of its components and in the interaction of each of these with the other components. Kunak has been sucessfully implemented with several clients. The objective of this phase 1 is to complete a feasibility study to find out the workability and profitability of the business venture. If the result of the feasibility study is positive, we will apply to phase 2 in order to implement our international expansion.

Keywords: iiot,disruptive,solution,internet of things,wireless,cloud,apps,ultra low power consumption,ultra energy efficient,end to end,autonomous,4 0 industry,monitoring,controlling
Sublinear Algorithms for Modern Data Analysis (SUBLINEAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 1473175.0
EU funding (EUR): 1473175.0
Participants: 1
Project status: SIGNED

Designing efficient algorithms for fundamental computational tasks as well as understanding the limits of tractability has been the goal of computer science since its inception. Polynomial runtime has been the de facto notion of efficiency since the introduction of the notion of NP-completeness. As the sizes of modern datasets grow, however, many classical polynomial time (and sometimes even linear time) solutions become prohibitively expensive. This calls for sublinear algorithms, i.e. algorithms whose resource requirements are substantially smaller than the size of the input that they operate on. We propose to design a toolbox of powerful algorithmic techniques with sublinear resource requirements that will form the theoretical foundation of large data analysis, as well as develop a nuanced runtime, space and communication complexity theory to show optimality of our algorithms. Specifically, we propose to: 1. design an algorithmic toolkit for sublinear graph processing that will form the basis of large scale graph analytics; 2. design a new generation of sublinear algorithms for signal processing that will become the method of choice for a wide range of applications; 3. develop a far-reaching set of techniques for lower bounding runtime, space and communication complexity of sublinear algorithms. The problems that we propose to solve are among the most fundamental algorithmic questions on the forefront of the rapidly developing algorithmic theory of large data analysis, which has been the focus of an extensive body of work in the research community. The algorithms and complexity theoretic results that we propose to design will cut at the core of fundamental computational problems and form the theoretical foundation of computing with constrained resources.
BIM based fast toolkit for Efficient rEnovation in Buildings (BIM4EEB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,Italy,Spain,Cyprus,Finland,Poland,Sweden,Sweden,Belgium
Call: Building information modelling adapted to efficient renovation (RIA) (H2020-NMBP-EEB-2018, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 6993942.63
EU funding (EUR): 6993940.0
Participants: 16
Project status: SIGNED

BIM4EEB aims to foster the renovation industry by developing an attractive and powerful BIM-based toolset able to support designers in the design and planning phase, construction companies to efficiently carry out the work and service companies to provide attractive solutions for building retrofitting. Additionally, public and private owners will be able to use a tool that eases decision making and asset management, thanks to the exploitation of augmented reality and the use of updated digital logbooks. BIM4EEB will deliver an innovative common BIM management system with linked data and a set of tools. This toolkit is the basic instrument for increasing semantic interoperability between software and stakeholders involved along the overall renovation process (design, planning, construction, performance assessment and management). End-users of the entire renovation process will actively participate to the development phases ensuring the full matching of project deliveries with the market expectations and maximizing the value of what is produced. In particular, two public administrations and two general contractor companies will validate the toolset in a social housing setting and private residential buildings in Italy, Poland and Finland. Inhabitants will benefit by the increase of building performances, quality and comfort. A focused market analysis will ensure effective market strategies. BIM4EEB will focus on delivering high levels of modularity between tools enabling the commercial exploitation as standalone products or services, or as part of a consolidated market offering, usable for AEC end users, consulting services or by other IT business areas if required. The developed best practices and guidelines for BIM adoption for public administrators and private stakeholders will be the bases of extensive dissemination actions to support the wide uptake of the project results and ensuring acceptance of BIM4EEB toolset by all stakeholders.

Keywords: toolkit,efficient renovation,energy saving,comfort,interoperability,management system,fast mapping,hvac,bacs,common data environment,inhabitants behaviour,foster renovation industry
Unveiling dynamics and substrate interactions of large protein complexes by NMR spectroscopy (NMRofLargeComplexes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Dynamic properties of proteins are essential for their function. NMR can reveal protein dynamics in solution on a broad range of timescales and at atomic resolution. However, NMR studies of large proteins remain challenging since conventional NMR methods are constrained to small proteins. The aim of this project is to extend the NMR size limit to large protein complexes by combining recent developments in site-specific labeling schemes with novel NMR methods employing state-of-the-art spectrometers. This will facilitate the study of functionally essential but so far uncharacterized dynamics and substrate interactions of two large protein complexes, providing unprecedented insight into the relationship between dynamics, structure and function. Since most proteins are dynamic, extending the scope of protein complexes that are amenable to NMR study is of great interest to many areas of molecular biology. Studies will be conducted on the eukaryotic exosome, a 370 kDa soluble, asymmetric decamer involved in RNA degradation and processing, and the 80 kDa Na+/H+ antiporter NapA, an integral membrane dimer involved in ion transport. For the exosome, individual subunits will be 13C-methyl labeled; the employment of sophisticated NMR methods will then permit the detection of functionally essential dynamics and RNA-substrate binding patterns of the exosome. As NapA is a low-yield membrane protein, an inexpensive 19F-labeling approach will be employed to reveal global transport dynamics and local gating motions. Exosome production and all NMR experiments are to be conducted in Remco Spranger’s lab at the University of Regensburg, Germany. NapA will be produced during a secondment in David Drew’s lab at Stockholm University, Sweden. This newly established international collaboration will permit integration of methods and knowledge to study protein systems previously inaccessible to NMR, strengthen the profile of the applicant and foster research of the involved institutes.

Keywords: nmr spectroscopy,protein dynamics,rna degradation,rna processing,exosome,membrane protein,transporter,site specific labeling,kinetics
The role of microfibrillated cellulose fibres to tune the rheological behaviour of fibre-cementitious and fibre-clay mixture for 3D printing application (CNF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 257619.84
EU funding (EUR): 257619.84
Participants: 2
Project status: SIGNED

The use of sustainable material in the construction sector is one of the solutions to reduce its environmental impact. In parallel, this sector is facing a technical revolution with 3D printing. The rheological behavior of cement/clay materials and its time evolution are significant in an extrusion and 3D printing process to ensure the layer-by-layer stability. Therefore, there is an urgent need to improve the adequacy between this process and the material (cement or clay) requirements. This proposal aims at elucidating the role of cellulose nanofiber or microfibrillated cellulose (CNF) on the complex rheological and mechanical properties of CNF-cement and CNF-clay for the further 3D printing process. The addition of CNF will affect the fresh-state and hardened state properties (durability, mechanical strength) resulting in a change of flow behavior of the composite, which is significant to tune the 3D printing process (so-called printability index). The processing of CNF gel can be mostly done in very low solid contents, where the high amount of water is one of the barriers to extrude the CNF gel with polymers, while the cement/clay materials are on the opposite side of the polymers extrusion process, as 25-50 wt% water is needed to prepare the slurry. If this content is a limiting factor in the extrusion process, it could be taken as an advantage in the preparation of the slurry. To go further, this project will explore the novel idea of UV-induced functions of CNF gel to activate the surface of the in-print layer and speeds up the hardening time due to entanglement of UV treated CNF of the mixture after having exposed by UV light. Taking advantage of the complementary expertise of the fellow and three world-leading institutions, the proposed research aim at unleashing the potential of CNF-gel as a raw material in the construction sector. This project will provide the candidate with a unique scientific repertoire and will be a crucial step in his future career.

Keywords: microfibrillated cellulose,rheology,cement,clay,3d printing
Looking for Historical Queerness in the Slavic-Speaking Dinaric Mountains (DINARKVIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2025-04-29
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

The project analyzes gender and sexual diversity in the Western Balkans right before the intense modernization of the 20th century. By examining written historical sources, the project sheds a new light on the life and everyday practices of regional gender non-binary people (tobelijas) or same-sex-loving individuals (male pobratimi and female posestrime). Both phenomena were extensively written about in early South Slavic ethnographies without references to their sexuality, sex, or gender. Due to the inability to obtain oral sources, and the ideological framework through which early researchers rendered their subjects heterosexual or invisible, the project establishes a two-tier hypothesis supported by two sets of archival sources. Without engaging the modes of early modern knowledge production in written sources, it is not possible to explore the existence and everyday practices of gender non-binary or same-sex-loving individuals before modernization. By using a contemporary theoretical framework from gender and queer studies, historical anthropology, and postcolonial studies, the project will analyze early Slavic ethnographic materials to identify cases of tobelijas and pobratimi/posestrime. The cases will be further explored using regional archives to reconstruct the everyday realities of individuals. In addition to disseminating project results via channels that reach specific disciplines, communication will target the societies researched (Croatia, Bosnia and Herzegovina, Montenegro, and Serbia) to shed light on local traditions in which queer individuals were visible and respected community members. Training through research will provide the research fellow with experience in advanced analysis of written sources (provided by the host institution), with a two-way transfer in handwritten text recognition (HTR) to the researcher and scaling up optical character recognition techniques (OCR) for the host institution.

Keywords: queer histories,western balkans,sworn virgins,ritual sisterhood,brotherhood,history of ethnographic research,modernization,colonial knowledge production