Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
HierARchical Multiscale NanoInterfaces for enhanced Condensation processes (HARMoNIC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Greece,Switzerland,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-10-01
End date: 2022-07-31
Duration (months): 46.0
Total project cost (EUR): 2999627.5
EU funding (EUR): 2999627.5
Participants: 5
Project status: CLOSED

This proposal focuses on key challenges facing human society: continuously increasing global demands for electricity as well as potable drinking water. Our long term vision consists of developing solutions related to water utilization for significant enhancement in i) efficiency of thermal power generation and ii) water harvesting to reduce the shortfall in global fresh water supply. The novel concepts that we propose rely on the realization of: 1) Precisely engineered, random yet hierarchical interface nanotextures, also with, controllable directionality, 2) Introducing a new norm of random biphilicity in the above interfaces at the submicron level, 3) Realization of novel superhydrophobic membranes through controlled coating of commercial hollow fiber membranes. 4) Novel methods of nanometrology to precisely and rationally describe the complex interfaces. Concept 1 is related to heat transfer exchange via dropwise condensation, where we target lifetime performance relevant to industrial surface condensers, while maximizing their heat transfer coefficient by up to an order of magnitude. By employing concept 2 we target novel material systems focusing on dew water harvesting in humid environments. Concept 3 targets new surface modification approaches for commercial membranes to achieve high efficiency in water desalination while ensuring anti-biofouling. For all the three concepts described above, a key component of our work will be to ensure economic scalability, of the precisely controlled textures, to large surface areas so that they can be converted to industrial products. For achieving optimal design, quantification and repeatable manufacturability of the aforementioned systems, we will employ novel metrology methods for hierarchical surfaces (concept 4) which will provide important theoretical feedback and understanding of the influence of critical surface structural parameters, through the entire project duration.

Keywords: dropwise condensation,heat transfer,condenser,water harvesting,water desalination,membranes,coatings,surface robustness,nanostructures,biphilic surfaces,nanocomposites,nanometrology
CONAN II - COmplete Nucleic acid ANalysis at genome scale at ultra-high throughput Phase 2 (CONAN II)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2021-10-31
Duration (months): 36.0
Total project cost (EUR): 2923315.0
EU funding (EUR): 2046320.5
Participants: 1
Project status: CLOSED

Depixus is developing an innovative new biotechnology for ‘complete nucleic acid analysis’ called SIMDEQ (SIngle molecule Magnetic DEtection and Quantification). SIMDEQ is being developed not only for standard DNA sequencing, but to also reveal previously undecipherable layers of information contained within the many subtle chemical signatures (epigenetic base modifications) that are found on both DNA and RNA. The emerging picture is that these base modifications form a ‘second genome’ that plays many vital roles in biology – from early embryonic development, to pathogenic defence mechanisms, and the evolution of many cancers. Current sequencing technologies have very limited abilities to read these modifications. This SIMDEQ technology can analyse individual nucleic acid molecules (DNA or RNA). Our current prototype instruments are highly robust and can be used to generate accurate genetic and epigenetic data, but have limited sample throughput. This CONAN 2 proposal describes an ambitious project that focusses on the development of a high-throughput system, known as ‘SIMDEQ Digital’, based on a CMOS chip (like those in digital cameras) on which many millions of electronically addressable micron-scale wells are fabricated. The basic concepts underpinning SIMDEQ Digital have been well validated during the H2020 SME Phase 1 project, and the goal of CONAN 2 is to industrialise advanced MEMS and CMOS technologies to develop a fully-functional system suitable for commercialisation. The release of SIMDEQ technology will not only allow Depixus to compete in the existing sequencing industry, but also to open new markets for genetic and epigenetic analysis, EU-wide and globally. Early access to this technology will provide great business opportunities especially for European SMEs, who will help pioneer an entirely new “complete genomics” ecosystem.

Keywords: single molecule analysis,nucleic acid analysis,cmos,mems,epigenetics,rna and dna sequencing,electronic device
PROTAC Linker Design: towards Functionality (PREDICT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Proteolysis Targeting Chimeras (PROTACs), small molecules capable of inducing degradation of a target protein, represent a novel strategy to design advanced chemical probes and therapeutic agents with the potential to target so far “undruggable” proteins. PROTACs are heterobifunctional molecules consisting of binding ligands to an E3 ubiquitin ligase and a protein of interest, covalently connected by a linker. Formation of a ternary complex of target protein, PROTAC and E3 ligase allows ubiquitination of the target protein, leading to its subsequent degradation by the proteasome. Due to the complexity of this ternary system, rational PROTAC design is highly challenging and novel PROTACs are to date commonly derived from trial-and-error approaches, typically using simple linkers to connect the two binding ligands. The potential to significantly stabilize and in doing so bias productive ternary complex formation, through design of functional linkers has not been exploited so far. My goal for this project is to identify and explore novel functional linker motifs which will enhance interactions within the ternary complex, such as PROTAC-ligase, PROTAC-target as well as cross-interactions between the E3 ligase and the target protein. The effects of halogen bonding, metal coordination and restricted conformational flexibility of the PROTAC linker on ternary complex formation and PROTAC degradation activity and efficiency will be systematically studied, benchmarked against related PROTAC degraders with non-functionalized linkers and taken as the basis to derive valuable structure-activity relationships. My long-term vision is to capitalize on this Fellowship to enhance my career by developing a rational-design strategy for novel PROTAC degraders capitalizing on functionalized linkers to efficiently degrade proteins so far considered to be “undruggable”.

Keywords: proteolysis targeting chimeras protacs,linker design,targeted protein degradation,structure activity relationships,non covalent interactions,molecular recognition,functional groups
PI3K/PTEN-related monogenic disease to understand cancer (PIPgen)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Spain,Italy,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 4099075.2
EU funding (EUR): 4099075.2
Participants: 11
Project status: SIGNED

There are more than 7000 rare diseases, affecting approximately 30 million European Union citizens. Eighty percent of rare diseases have monogenic origin and are often chronic or life-threatening. Several of these genetic mutations are also implicated in cancer, a disease of epidemic proportions (>14 million new cases/year worldwide). Genetic alterations in the PI3K/PTEN pathway are common events in both monogenic rare diseases and in cancer. Despite the molecular commonalities, these two pathologies have predominantly been investigated as independent entities. We aim to take advantage of the knowledge that has been generated regarding the role of PI3K in cancer to better understand the recently-discovered PI3K-related rare diseases (overgrowth syndromes, primary immunodeficiencies and cognitive deficiencies). Conversely, discoveries emanating from PI3K-related rare diseases will impact in the understanding of cancer. Ultimately, this cross-fertilization will impact on the clinical strategies to treat both rare diseases and cancer. Our network, under the acronym of PIPgen, aims to (1) produce the next generation of scientists that can navigate with ease between academic, industrial and clinical sectors and have the scientific and softs skills to convert research findings into commercialization and clinical applications, and (2) generate innovative knowledge that can be translated to the diagnosis and treatment of both rare diseases and cancer. This network provides a pan-European interdisciplinary and intersectorial training program of excellence bringing young researchers together with world leading academics, clinicians, entrepreneurs with experience from the pharma industry, corporate research as well as with dissemination and outreach activities. PIPgen has been conceived to make a real therapeutic impact both in rare diseases and cancer, based on basic bioscience.

Keywords: pi3k,rare diseases,cancer,signalling,pros,phts,apds
An innovative Solar Lighting System to replace artificial lighting in all types of indoor spaces with free and healthy sunlight. (SOLIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Israel
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sunlight is abundant and free for all. However, the Sun doesn't always shine in the right place at the right time. For example, many big indoor spaces like office blocks and warehouses rely exclusively on artificial lighting as light-source even during daytime. Therefore, bringing solar light where it doesn't reach can be very useful and convenient. SL enables solar light to be transmitted indoors to areas currently void from sufficient sunlight. SOLIS is an innovative, practical and effective lighting system that maximize collection of sunlight from the outside of the buildings (on rooftops or southern walls) and distributes it effectively indoors. Thus, energy is saved in two different ways: by reducing the electrical load required for artificial lighting and by lowering the heat emitted by the lighting , (thereby reducing cooling costs). The SOLIS light dispersing unit is a patent pending dual source lamp, that switches from sunlight to LED. During the day, SOLIS lights interiors using free, natural light. As the sun starts to set and light levels fall, energy-efficient LEDs activate automatically to provide illumination for early morning and evening use. The result is a solar lighting solution that significantly cuts energy costs and improve light quality.

Keywords: natural lighting,lowering co2 emissions,energy consumption,indoors lighting,commercial buildings,sunlight collector,full spectrum light
Content Integration (PJ19 CI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Coordination and support actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Germany,Spain,Spain,Ireland,Italy,Italy,Malta,Switzerland,Norway,Belgium,Croatia,Hungary,Lithuania,Slovakia,Sweden,Norway,Poland,Belgium,France,France,France,Czechia,Denmark,United Kingdom,United Kingdom
Call: Content Integration (H2020-SESAR-2015-2, 2015)
Start date: 2016-11-01
End date: 2019-12-31
Duration (months): 38.0
Total project cost (EUR): 25145687.35
EU funding (EUR): 6849142.05
Participants: 40
Project status: CLOSED

SESAR 2020 Programme aims to modernise and harmonise the European ATM System from operational and technological perspective. It will develop and validate different ATM solutions that will contribute to achieving its high level performance objectives. In this complex context, it is crucial to have a transversal activity that generates a consolidated big picture of the future European ATM System – the SESAR 2020 Concept of Operations, the High Level Architecture options, Services and the associated performance results. In SESAR2020 this important task will be under the responsibility of PJ19 – Content Integration. The other main task of the PJ19 will be to provide steering guidance, principles and frameworks to support and facilitate the production and the integration of the content produced by SESAR2020 Solution and Enabling projects. It will enable the assessment of the overall performance of the SESAR Solutions brought together against the performance improvements expectations. It will provide the main input for the future updates of the European ATM Master Plan. PJ19 will bring together 16 partners. The broad representation of experts from the European Air Navigation Service Providers, Airports, Airborne and Ground industries and Network Manager will provide the necessary skills to successfully and efficiently carry out the project tasks and to meet the expectations of the SJU. PJ19 will produce a set of deliverables that consolidate the SESAR2020 Programme outcomes and provide an integrated reference material on a yearly basis. All these tasks will be performed in collaboration with all SESAR 2020 projects throughout an interactive, continuous and iterative process on all aspects of content integration. PJ19 deliverables will support the SJU to assess the maturity of the SESAR Solutions for delivery to the SESAR Deployment Manager, to monitor the SESAR2020 Programme execution and to support the SJU decision making.

Keywords: content,integration,consistency,coherency,holistic view,performance,consolidation,maturity,assessment,modelling,architecture,system,operational,service,information,concept
Understanding the impact of parental occupation on gender differences in field of study choice in Germany (GENSEG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-02
End date: 2019-10-01
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

While in many countries women have been increasing their participation in higher education, fields of study continue to be segregated by gender. Men dominate the technical fields which include mathematics, engineering and the physical sciences, whereas women tend to engage in areas that have a social and caring dimension. Despite numerous policies to enhance gender equalities in society, gender segregation in higher education, ironically, appears to be more pronounced in post-industrial countries, such as Germany, than in developing/transforming societies. Although gender differences in field of study and occupational choices are shaped by multifarious influences, the role of parents might be particularly worth attention because parents are the primary and one of the most influential socialising agents in childhood and adolescence. In fact, one possible source of students’ knowledge about and interest in a particular field of study and career early on stems from parental education and occupation. The impact of parents’ occupational fields and its gender typicality has received less attention than parental education in early research. Even though some studies have identified the association of parental occupations with students’ engagement in gender-atypical fields of study, they do not provide any empirical evidence of the mechanism for the relationship. Despite the possibly significant influence of parental occupation on the educational and career choices of adolescent boys and girls, previous quantitative studies rarely examined the mechanisms for the relationship between such gender differences and parental occupations. With the proposed research “Understanding the impact of parental occupation on gender differences in field of study and occupational choices in Germany”, that comprises 3 projects using secondary and primary data, I seek to offer new evidence on how parental occupations influence students’ choices of a gender-atypical field of study and career.

Keywords: gender inequalities in education,educational and occupational choices,parental occupations,german education
Sexual Plant Reproduction – Seed formation (SexSeed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Italy,Italy,Australia,United States,Japan,Portugal
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 751500.0
EU funding (EUR): 720000.0
Participants: 10
Project status: CLOSED

By 2050, it is estimated that the human population will reach 9 billion. To feed this growing population, it will be necessary to at least double agricultural yields, without increasing the amount of arable land. Understanding the factors that regulate sexual reproduction will enable this critical aspect of agricultural production to be engineered for increased productivity, without increasing arable land. Our project will provide new insights into the network controlled by SEEDSTICK (STK), a MADS box transcription factor, which is the master regulator in the production of seeds. The objective of this proposal is to strengthen research partnerships through staff exchanges and networking activities, at international and intercontinental levels. By combining transcriptomic and genetic approaches, we aim to uncover new functions for STK targets and implicate them in putative signalling cascades, increasing our knowledge on the network that controls seed formation in Arabidopsis. Arabidopsis is an excellent model to study seed formation, as it shares a conserved developmental program with major seed-producing crop plants, important to improve not only gross agricultural productivity, but also the composition of seeds and hence the production of components used for high added-value seed-derived products. The growing importance of seeds and seed-derived products to humanity and the central role of STK in seed development means that this project has great potential to contribute to Europe’s excellence and competitiveness in the world. Detailed analysis of the network of regulatory genes controlling reproductive development in Arabidopsis represents the biological theme around which our training programme will be built. By taking advantage of the scientific competences developed by the partners, it will be possible to expand our knowledge of seed formation in the model species and then to transfer this knowledge horizontally into vital agricultural crop species.

Keywords: arabidopsis,seed development,fertilization,regulatory genes
Extreme deformation of structured fluids and interfaces. Exploiting ultrafast collapse and yielding phenomena for new processes and formulated products (ExtreFlow)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands,United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2021-04-30
Duration (months): 72.0
Total project cost (EUR): 1499186.0
EU funding (EUR): 386929.96
Participants: 2
Project status: CLOSED

The increasing demand for environmentally friendly, healthier, and better performing formulated products means that the process industry needs more than ever predictive models of formulation performance for rapid, effective, and sustainable screening of new products. Processing flows and end use produce deformations that are extreme compared to what is accessible with existing experimental methods. As a consequence, the effects of extreme deformation are often overlooked without justification. Extreme deformation of structured fluids and soft materials is an unexplored dynamic regime where unexpected phenomena may emerge. New flow-induced microstructures can arise due to periodic forcing that is much faster than the relaxation timescale of the system, leading to collective behaviors and large transient stresses. The goal of this research is to introduce a radically innovative approach to explore and characterize the regime of extreme deformation of structured fluids and interfaces. By combining cutting-edge techniques including acoustofluidics, microfluidics, and high-speed imaging, I will perform pioneering high-precision measurements of macroscopic stresses and evolution of the microstructure. I will also explore strategies to exploit the phenomena emerging upon extreme deformation (collapse under ultrafast compression, yielding) for new processes and for adding new functionality to formulated products. These experimental results, complemented by discrete particle simulations and continuum-scale modeling, will provide new insights that will lay the foundations of the new field of ultrafast soft matter. Ultimately the results of this research program will guide the development of predictive tools that can tackle the time scales of realistic flow conditions for applications to virtual screening of new formulations.

Keywords: structured fluids,complex fluids,interfacial rheology,surface viscoelasticity,bubble dynamics