Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Workers, Gypsies, and the Market: The Anthropology of New Fascism in Eastern Europe (WOGYMARKET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Slovakia
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-01-20
End date: 2017-05-19
Duration (months): 28.0
Total project cost (EUR): 254025.33
EU funding (EUR): 254025.33
Participants: 1
Project status: CLOSED

This research focuses on how market transformation gives rise to new patterns of politics that among some social groups in Eastern Europe emerge as new fascism. By focusing on two social groups that have encountered the most significant transformation in effect of the economy re-structuring after state-socialism and whose positions caused the major challenges for academics and policy makers -- heavy industry workers and Roma/Gypsies -- the project aims to offer new perspective on the anthropology of social and political movements in Europe. Building upon years-long fieldwork in Slovakia, Poland and Ukraine, the project investigates how individualism and market calculation in what I call post-peasant setting after state-socialism have paved the way for populist movement that have increasingly taken anti-Roma attitudes among social groups that have not previously shown sensitivity to ethnic conflict or neo-fascist protests. The anthropology of new fascism therefore analyses the social and political movement from the ordinary perspective of everyday eceonomic models, balancing the dominant view on macro-structural or identity-centred 'culturalist' approaches. Theoretically, the project combines the recent dialogue of anthropology and economy with literature on transformations of polities, particularly in post-socialist setting. The project intends to argue that the current rise of populism and neo-fascism in Eastern Europe can only partially be explained as being the effect of neoliberal globalization. It is argued, instead, that the perspective on the everyday distribution of power in post-peasant society and how it has been reproduced via uneven development alongside with the changes in livelihood strategies under the market proliferation into the spheres previously dominated by community reciprocity shall be investigated in order to develop a new theory in the field of anthropology of social and political movements in/of Europe.

Keywords: workers,roma/gypsies,market,post-socialism,social and political movement,populism,fascism,eastern europe,economic and political anthropology,civility and tolerance,european integration
Functional Ion Conductance and Sensing (FUNICIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-06-01
End date: 2016-05-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

This proposal presents unique approaches for the functional characterization of charged interfaces and interfacial phenomena at the nanoscale, through the implementation of an innovative and quantitative ion flux imaging technique. The scientific scope of the project involves the development of a frontier high resolution electrochemical imaging technique, based on scanning ion conductance microscopy that will be capable of probing the nanoscale structure and charge heterogeneity at almost any kind of interface. This represents a major fundamental science aim, that will also open new horizons for the exploration of nanomaterials, including novel electrode materials (graphene and graphene oxide, carbon nanotubes), as well as for imaging self-assembled nanostructures of metallic nanoparticles (NPs). The methodology will allow us to determine the microscopic physicochemical characteristics of individual NPs and their assemblies at soft interfaces and reveal the reactivity of electrocatalytic substrates for fuel cell reactions. We will be able to identify active sites on catalysts and relate these directly to structure - of huge benefit for the understanding and rational design of future functional materials. The research proposal is highly interdisciplinary, and there is a natural fit between the Fellow’s profile and activities at the Host Warwick group. The proposal draws on Fellow’s strong multidisciplinary background in chemistry, mathematical modelling and microtechnology, especially in understanding charged interfaces and nanoscale ion flows, that will be married with the world-leading research on innovative imaging techniques being developed at Warwick. With considerable support and world-leading expertise from the Host group and its collaborators, this project will provide the applicant, Dr. Dmitry Momotenko, with an outstanding opportunity to develop personally and professionally, by pioneering a new area of research in a new geographic location.

Keywords: nanoscale imaging,sicm,scanning probe,diffuse double layer,graphene,catalysis,nanopipette.
Diversity-Oriented Synthesis of Conformationally Constrained Peptidomimetics (DOS-PEPTIDOMIMETICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-06
End date: 2016-10-05
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

There is an undoubted need of new small molecule libraries with high levels of scaffold diversity in order to address challenging ‘undruggable’ biological targets which have proven largely intractable to small molecule modulation using traditional compound libraries. The efficient de novo generation of such collections presents a formidable challenge to the synthetic chemist; over the course of the last decade diversity-oriented synthesis has established itself as a powerful tool in this regard. The research outlined in this Marie Curie Fellowship proposal is advancing the impact that synthetic organic chemistry will have on the drug discovery process employing diversity-oriented synthesis. We proposed the preparation of a novel and diverse library of conformationally constrained peptidomimetics containing quaternary stereocenters derived from B/C/P approach with increased biological relevance. In order to provide a visually accessible representation of the abstract concepts of chemical space and the molecular diversity of our new chemical libraries a computational assessment will be developed. As a final step, the small-molecules obtained will be screened to identify new molecular targets against cancer and infectious diseases. This is a multidisciplinary project that involves a highly valuable education for the candidate in new scientific aspects related to her research field.

Keywords: organic chemistry,medicinal chemistry,diversity-oriented synthesis,conformationally constrained peptidomimetics
Drought impacts on plant-soil interactions and ecosystem stability (S-CLIMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-20
End date: 2016-10-19
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

Soils and the communities within them have a central role in numerous ecosystem processes, including complex interactions with biotic and abiotic factors, such as climate. The mechanisms of how soil microorganisms interact with climate remain unknown and there may be ways of mitigating climate change impacts through manipulation of soil microbial processes. Mediterranean habitats are particularly threatened by climate change, and are predicted to experience an increase in annual average temperature, by up to 6oC in summer, and a 30-45% decrease in summer precipitation by the end of this century. This region is a conservation priority as it contains high plant diversity and a high percentage of endemic species. The predicted increase in extreme drought in this ecosystem could have wide-ranging impacts on both natural and agricultural habitats, including loss of biodiversity and land degradation. These negative effects will only be mitigated through a thorough understanding of the relationships between drought, plant communities and soil processes. Plants are linked with the soil community through root exudates, which are compounds released by roots into the soil that interact with other plants and microorganisms. However our understanding of the mechanisms behind these interactions is incomplete. In this project we aim to acquire a fuller understanding of the mechanisms of these interactions and the importance of soil communities for ecosystem stability. Specifically, the project has the following objectives: 1) To describe the impacts of drought-driven changes in plant productivity and diversity on the soil community and below-ground plant traits. 2) To characterise the interaction between soil fertility and drought on plant-soil interactions with a particular focus on demand for root exudates under low fertility. 3) To understand the effect of extreme drought on plant-pathogen interactions, and how that in turn affects plant community composition.

Keywords: plant-soil interactions,drought,root exudates,mediterranean
Genetic and Environmental Determinants of Comorbid Medical Conditions in Major Psychiatric Disorders: The Med-Psych Study (MEDPSYCH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 223002.2
EU funding (EUR): 223002.2
Participants: 1
Project status: CLOSED

Medical conditions (MC), such as obesity, diabetes and cardiovascular disorders are more prevalent in people with major psychiatric disorders (major depressive disorder, bipolar disorder, schizophrenia). The relationship between mental and physical disorders is complex and not clearly understood. Although it is well reported that MC have a high impact in the lifespan and mortality of people with psychiatric disorders. Recent studies support the hypothesis that there may be shared aetiological factors, including environmental and genetic factors, between psychiatric disorders and MC. In a cross-sectional study (PISMA-ep) of a representative sample of the Andalusian population, 4,500 individuals donated a biological sample for genetic studies. Diagnosis of psychiatric disorders was ascertained using the Mini International Neuropsychiatric Interview (MINI). In addition to psychological, social and sociodemographic information, a wealth of detailed data on chronic, comorbid MC were collected using a validated checklist. OBJECTIVES: 1) examine the prevalence and characteristics of MC in individuals with major psychiatric disorders and compare them with psychiatrically healthy controls; 2) DNA extraction and genotyping of candidate genes/polymorphisms 3) explore genetic and environmental factors in comorbid mental and physical diseases. METHODS: we will use available statistical packages to determine the frequency of comorbid MC in psychiatric disorders, stratifying by social and environmental risk factors. We will perfom DNA extraction and genotyping of candidate genes in the total sample. EXPECTED RESULTS: we should expect to find higher prevalence of MC in people with psychiatric disorders, as well as genetic and environmental increased risk in individuals with a history of comorbid MC in psychiatric disorders.

Keywords: psychiatric disorders,medical conditions,candidate genes,depression,obesity,environmental risk factors.
Mechanisms of Fungiculture in Ambrosia Beetles (FARMING IN BEETLES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 168794.4
EU funding (EUR): 168794.4
Participants: 1
Project status: CLOSED

Farming insects are one of the most exciting examples for the success of symbioses in nature. Ants, termites and ambrosia beetles started to grow fungi for food 40–60 million years before the rise of human agriculture. Research on fungus-farming ants has revealed the association with nitrogen-fixing bacteria as fungus fertilizers and the application of antibiotics produced by symbiotic bacteria to control garden parasites. However, in the ecologically and economically important ambrosia beetles, it remains unknown how the beetle farmers induce the fruiting structures in their cultivars, how antagonistic fungi are suppressed, and which role bacteria play in the nitrogen budget of the insects. In the proposed project, I aim (i) to characterize the fungal garden community with and without the presence of farming beetles, (ii) to investigate ambrosia beetle defenses against pathogenic fungi as well as synergistic effects towards the cultivars, and (iii) to determine if fungus gardens are fertilized by certain bacteria. The results will yield important insights into the importance of multi-partite symbiotic associations for the maintenance of agriculture and, hence, the evolution of sociality in ambrosia beetles. Funding by an IEF would allow me to combine my expertise on the behavioral ecology and rearing of ambrosia beetles with state-of-the-art molecular and chemical-analytical techniques available at the Max Planck Institute for Chemical Ecology (MPI-CE). I am confident that this combination will enable us to obtain transformative results and set new paradigms in the research on ambrosia beetle symbiosis. Furthermore, the localization at the MPI-CE will provide me with a unique opportunity to obtain conceptual and methodological expertise in chemical analytics and molecular ecology, and it will thereby significantly contribute towards achieving my ultimate career goal of obtaining a leading position in fundamental research in evolutionary and behavioral ecology.

Keywords: insect agriculture,sociality,mutualism,symbiosis,farming,in vitro assays,ambrosia beetles,scolytinae
Trait diversity: assemblage of communities and their feedbacks to Ecosystem Multifunctionality (TANDEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-12-01
End date: 2016-11-30
Duration (months): 24.0
Total project cost (EUR): 152067.6
EU funding (EUR): 152067.6
Participants: 1
Project status: CLOSED

In order to deal with the generalized losses in biodiversity and its adverse effect on the provision of ecosystem, services, it is critical to understand the mechanisms behind the assemblage and coexistence of species, including the relative effect of environmental and land-use factors, and its feedbacks to ecosystem functioning. There is growing consensus that the quantification of the kind, diversity, and relative abundance of functional traits in biotic communities, collectively defined as functional diversity (FD), can greatly contribute to understanding the assemblage of biodiversity and its effects on ecosystem service assessment and management. The latin word 'Tandem' means 'finally', and refers to a groups of persons or objects working together. The TANDEM (‘Trait diversity: Assemblage of commuNities and their feeDbacks to Ecosystem Multifunctionality’) will join the efforts of several ecologists aiming to reconcile the responses of functional traits to environmental variables with their effects on ecosystem functioning. Using this unified framework, the TANDEM project will address many of the key questions that remain to be solved in order to fully incorporate the functional component of biodiversity into theoretical and applied models of future biodiversity changes. A set of subprojects are considered, ranging from the study of processes shaping species coexistence, the effects of diversity on ecosystems functioning and to the role played by different traits and by phylogenetic differences on the assembly processes of plant communities across environmental and disturbance gradients. The project will address these challenges by merging different aspects from plant ecology (functional, evolutionary and community ecology) with the development of a new set of tools to estimate the functional diversity of biological communities.

Keywords: functional trait diversity,niche,community ecology,functional ecology,community assembly,species coexistence,ecosystem function,multifunctionality,biodiversity
Membrane protein dynamics and interactions (MPFP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-06-01
End date: 2016-05-31
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Many important protein families such as signaling receptors, ion channels, structural proteins and enzymes are embedded in the membrane of cells. Despite their importance, understanding of their structure, dynamics and interactions lacks behind that of soluble proteins due to their hydrophobic nature which makes them difficult to study experimentally. We propose to recruit and retain in the Division of Metabolic and Vascular Health at the University of Warwick, Judith Klein-Seetharaman, membrane protein expert from the University of Pittsburgh, USA. In an interdisciplinary approach combining computational and experimental studies, she looks at these proteins from both, structural and systems biology point of views. She proposes to study membrane protein folding by characterizing denatured states of the model system and G protein coupled receptor mammalian rhodopsin in molecular detail by predicting these states and experimentally validating them with biophysical approaches such as 19F NMR spectroscopy. She will extend these studies to mutant rhodopsins that cause the retinal degeneration disease Retinitis pigmentosa and that are known to misfold and to other membrane proteins, in particular carnitine palmitoyltransferase 1A, of particular interest to our division. She will also investigate interactions of proteins with lipids using coarse grained simulations and in a systems biology approach interactions with other proteins to define the human membrane receptor interactome by establishing new collaborations within the division and with the Chemistry department. In this approach, computational machine learning methods are used to integrate large –omics databases to predict what interactions are likely for any given membrane receptor and then test the predictions using surface plasmon resonance and the TOXCAT assay. She proposes to disseminate her results in lecture series, conferences, a website, journal publications and through implementation of a graduate course.

Keywords: rhodopsin,g protein coupled receptors,lipid-protein interactions,membrane proteins,protein folding,misfolding,denatured states,interactomes,protein-protein interactions
Dual cancer nanotherapies combining magnetic and plasmonic hyperthermia (DUALNANOTHER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

This project is designed to provide answers to questions not yet covered in the literature regarding hyperthermia cancer therapy based on the activation of magnetic and/or plasmonic nanomaterials. It aims at understanding and measuring nanoparticle-based heat-generating potential in environments that gradually approach the in vivo situation. The originality of the approach proposed is to combine in-depth physical studies (magnetic, plasmonic) of nanomaterials in biological environment while exploring new therapeutic modalities. Two main issues will be addressed: (1) the influence of magnetic or plasmonic nanoparticle confinement inside cells on heat-generating potential; (2) the possible synergism between magnetic and plasmonic hyperthermia, with a view to combined therapy, and their cumulative efficacy in solution, in vitro cell models, and in vivo tumour models. These issues will be addressed at several levels, ranging from materials chemistry to antitumoral applications in living animals, by exploiting multiple disciplines. To open the way to new therapeutic tools, it will be necessary to test a wide variety of nanoparticles with different compositions, shapes and sizes, provided by leading teams in nanomaterials synthesis, as well as to develop appropriate nanometrologic methods to detect, quantify and characterize the different nanostructures in their biological environment.

Keywords: nanomedicine,magnetic hyperthermia,plasmon thermal treatment,cancer therapy,magnetic nanoparticles,plasmonic nanobjects,cell culture