Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Diabetes Reversing Implants with enhanced Viability and long-term Efficacy (DRIVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Cross-cutting and enabling materials technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ireland,Ireland,Ireland,Italy,Spain,Italy,Italy,Czechia,Netherlands,Netherlands,United Kingdom
Call: Biomaterials for the treatment of diabetes mellitus (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 8832062.75
EU funding (EUR): 8832061.5
Participants: 17
Project status: CLOSED

Diabetes mellitus is a chronic disease characterised by high blood glucose due to inadequate insulin production and/or insulin resistance which affects 382 million people worldwide. Pancreatic islet transplantation is an extremely promising cure for insulin-sensitive diabetes mellitus (ISDM), but side effects of lifelong systemic immunosuppressive therapy, short supply of donor islets and their poor survival and efficacy in the portal vein limit the application of the current clinical procedure to the most at-risk brittle Type I diabetes (T1D) sufferers. The DRIVE consortium will develop a novel suite of bio-interactive hydrogels (β-Gel) and on-demand drug release systems to deliver islets in a protective macrocapsule (β-Shell) to the peritoneum with targeted deposition using a specialised injection catheter (β-Cath). Pancreatic islets will be microencapsulated in β-Gels; biofunctionalised injectable hydrogels containing immunosuppressive agents and polymeric microparticles with tuneable degradation profiles for localised delivery of efficacy cues. These β-Gels will be housed in a porous retrievable macrocapsule, β-Shell, for added retention, engraftment, oxygenation, vascularisation and immunoprotection of the islets. A minimally invasive laparoscopic procedure (O-Fold) will be used to create an omental fold and at the same time deliver β-Shell. An extended residence time in β-Gel will enhance long-term clinical efficacy of the islets and result in improved glycemic control. The novel β-Gels will also be developed as human three-dimensional in-vitro models of in-vivo behaviour. Islet harvesting and preservation technologies will be developed to facilitate their optimised yield, safe handling and transport, and ease of storage. DRIVE will also enable the future treatment of a broader range of T1 and insulin-sensitive T2 diabetics by working with induced pluripotent stem cell experts to ensure the compatibility of our system with future stem cell sources of β-cells.

Keywords: biofunctionalised hydrogels,islet microencapsulation,localised immunosuppression,3d in vitro islet culture systems,minimally invasive devices,retrievable macroporous shell
Neurocomputational mechanisms underlying age-related performance changes in goal-directed decisions from experience (AGERISK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2019-03-02
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The ability to make goal-directed decisions concerning one’s general well-being declines in later life. The primary—and potentially improvable—factor impacting this decline in decision-making performance is the learning process that precedes a decision. However, little is known about age-related changes in the neurocomputational mechanisms that underlie these learning processes. The goal of the proposed project is to identify these changes. The project will first identify age-related variability in decision-making performance across individuals and task environments, and then test what computational models from artificial intelligence best explain this variability. Because previous research has shown that decision-making performance declines as the complexity of the choice environment increases, the focus will be on performance in cognitively demanding environments that require goal-directed decisions from experience. The project will combine data from lab-based and home-based neurocognitive experiments, capitalizing on new developments in online experiments and webcam based eye tracking. The applicant’s unique research background brings the interdisciplinary range of skills together that is required for the project, combining experience in computational modelling techniques from artificial intelligence, large-scale data analysis from computational linguistics, and neurocognitive experiments. The proposed project promises to further the scientific understanding of the functional link between aging and decision-making performance. Its findings will ultimately help to empower aging decision makers to navigate cognitively demanding choice environments.
Increased Safety and robust certification for ditching of aircrafts and helicopters (SARAH)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Belgium,France,France,France,France
Call: Addressing aviation safety challenges (H2020-MG-2016-SingleStage-INEA, 2016)
Start date: 2016-10-01
End date: 2020-03-31
Duration (months): 42.0
Total project cost (EUR): 6636395.0
EU funding (EUR): 6636393.75
Participants: 13
Project status: CLOSED

SARAH is concerned with establishing novel holistic, simulation-based approaches to the analysis of aircraft ditching. It is build up from a consortium of experts from OEM industries, experienced suppliers of simulation technologies, established research institutions and representatives of the certification authorities. Results of SARAH are expected to support a performance-based regulation and certification for next generation aircraft and helicopter and to enhance the safe air transport as well as to foster the trustworthiness of aviation services. Aircrafts and helicopters often travel above water and thus have to prove a safe landing under emergency conditions. The specific challenge is to minimize the risk of injury to passengers and to enable safe evacuation. Accordingly, the motion of the aircraft/helicopter along with the forces acting on the structure are studied for controlled water impact during the design phase of an aircraft. Ditching has close links with crash simulation, but also distinctive features. Examples refer to hydrodynamic slamming loads on airborne vehicles and complex hydromechanics (partially at very large forward speeds) as well as the interaction of multi-phase fluid dynamics (involving air, water, and vapor phases) and structure mechanics. Design for ditching involves more than the analysis of loads and subsequent strengthening of the structure. It often requires adjustment campaigns for the handling of the vehicle during approach and the identification of favorable approach/flight-path conditions in line with the pilots flying capabilities to minimize the remaining kinetic energy of the vehicle to be transferred into the water. In conclusion, a pressing need for more advanced studies to support the development of next-generation, generalized simulation-based ditching-analysis practices is acknowledged by all stakeholders. The public interest in safety makes this proposal an ideal candidate for a European research proposal.

Keywords: ditching,aircrafts,helicopters,unconventional configuration
ENergy efficient Far InfraRed process of manure valorisation (ENFIR)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Infrarrojos para el Confort S.L is a company specialised in designing and building Far Infrared (FIR) emission equipment for different sectors where high energy efficiency heating is demanded. Livestock sector produces more than 1.29 billion of tonnes/yr of manure in European states, which is not processed. ENFIR project aims to adapt and implement our developed pilot plant in the livestock industry for transforming manure into pelletized compost without external energy consumption. ENFIR process is based on dehydration of manure by our FIR technology to transform it into organic fertilizer for agriculture use at a production cost of 6.8€/m3 (up to 3 time less than current valorisation process) and 30 % of energy saving compared to current methods of heating by steam. ENFIR is able to dry manure up to 15 % of water content in 8 hours cycles with almost no external energy consumption, thanks to the generated gases during the dehydration process that will generate the electricity to feed the whole process. ENFIR process will have a selling price of 216.000 €/unit annd it is able to produce more than 1.500 ton/year of organic fertilizer from livestock manure. Farmers will be able to recover the investment in a half year being much more competitive, without taking into account the saving on manure management expenses. As consequence of the expected market ENFIR solutions will be able to create benefit over 8.38M€ with a ROI (5 years) of 3.25 and 9 new jobs.

Keywords: far infrarred,manure treatment,valorisation,far infrared technology,energy efficiency,circular economy,livestock industry,compost,pellets,energy savings,cost effectiveness
Metabolic Mechanical Materials: Adaptation, Learning & Interactivity (M3ALI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 1998750.0
EU funding (EUR): 1998750.0
Participants: 1
Project status: SIGNED

The central objective of M3ALI is to introduce concepts for adaptation, simplistic learning by training (physical exercise, not teaching), and interactivity in mechanically stimulated polymer materials by developing metabolic modules for mechanical memories (that can also be forgotten), for down-stream chemical processes and for active communication. The key experimental methodology is based on two classes of molecularly engineered mechanoprobes (MPs) that are capable of defined downstream reactivity up to the level of chemical reaction networks (CRNs). We build on our recent concept of DNA-based mechanofluorescent folding motifs in hydrogels, and extend it to cyclic disulfide MPs, and embed them into hydrogels and elastomers of controlled topology. DNA-based MPs will engage in DNA-based downstream reactions, while disulfide MPs will engage in complementary radical chemistry. The key concept is to code mechanical deformation into chemical signals that can be processed ultimately in CRNs to enable a behavioral evolution of the materials systems by installing memories, as well as by signal amplification, processing, translation and transport, and where the processed chemical information is fed back into the material to develop a full mechano-chemo-mechano signal processing language. We will break new ground in proof-of-concept applications in mechanical training and forgetting (physical exercise similar to muscle training), adaptive and interactive soft robotics, adaptive mechanical metamaterials, as well as interactive mechanical synchronization and interactive cell/material systems. Our approach to metabolic mechanical materials that use systems chemistry concepts to empower mechanical materials with the capacity to adapt, learn and interact profoundly contrast present research on responsive materials. In long term such concepts will provide the basis for more life-like materials systems capable of true adaptivity, interactivity and co-evolution in open systems.

Keywords: adaptive and interactive materials,supramolecular polymers,sacrifical bonds,chemical reaction networks,dna nanoscience,mechanochemistry,dna hydrogels,non equilibrium systems
Origin of volatile elements in the inner Solar System (VOLATILIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1396300.0
EU funding (EUR): 1396300.0
Participants: 1
Project status: CLOSED

The objective of project VOLATILIS is to investigate the origin(s) of volatile elements on Earth and other planetary bodies in the inner Solar System. Since primitive and differentiated asteroids, planetary embryos, and the Earth-Moon system represent different stages of planet formation, studies of chondritic meteorites and samples from Vesta, Mars, the Moon, and Earth can provide constraints on the evolution of planetary volatiles from primordial to present-day compositions. However, indigenous volatiles in extraterrestrial samples are often masked by solar and cosmogenic contributions. Only combined analyses of noble gases and other volatiles (N, H) allow the observed volatile signatures to be resolved into constituent components (atmospheric, solar, cosmogenic, indigenous). The Centre de Recherches Pétrographiques et Géochimiques (Nancy, France), the PI’s host institute, is the only laboratory that is equipped with static noble gas mass spectrometers for coupled N-noble analyses of small-sized samples, and with two secondary ionization mass spectrometers for non-destructive volatile element measurements. By coupling these high-precision analytical techniques, we will be able to reliably characterize indigenous planetary volatiles, and to assess the importance of volatile storage during primary accretion or late addition via comets and meteorites. Furthermore, we aim to develop the protocols for N isotope analysis by ion microprobe and by static mass spectrometry in multi-collection mode; these methods will allow us to target micron-sized samples (such as melt inclusions) for N analyses and to improve the analytical precision for coupled N-noble gas studies, respectively. The new data obtained here can be integrated as critical parameters into geochemical and astrophysical models of volatile accretion and fluxes in the inner Solar System, and they are expected to be of great interest to the geo-/cosmochemistry, astrophysics, and astrobiology communities.

Keywords: origin of volatiles,nitrogen,hydrogen,noble gases,secondary ionization mass spectrometry,static mass spectrometry,planet formation and evolution
Electrocatalytic Nanoreactors for Absorption, Detection and Decontamination of Hazardous Compounds (NANOELECTROCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-12-01
End date: 2019-05-31
Duration (months): 18.0
Total project cost (EUR): 149912.0
EU funding (EUR): 149912.0
Participants: 1
Project status: CLOSED

Chemical warfare agents (CWA) are one of the most odious weapons of mass destruction, designed to incapacitate humans by causing blistering, choking, internal bleeding and vomiting on a grand scale. CWA are inexpensive and relatively easy to synthesise making them accessible to terrorist groups, providing a means for the administration of large scale damage with only small quantities of materials. Current state-of-the-art methods to detect or decontaminate CWA lack efficiency and flexibility and, with tensions in numerous war zones pushed to breaking point. By building on the fundamental scientific discoveries made in the ERC Consolidator grant (No 277784, NANOMOL), we shall extend and develop the application of electrochemically active carbon nanoreactors for the detection and decontamination of CWA, such as mustard gas and other agents. The nanoscale electrochemical platform (NANOELECTROCHEM) developed in this Proof of Concept (PoC) project is expected to be universally applicable for the triple-use (absorption + detection + decontamination) of a wide spectrum of CWA and many other harmful anthropogenic compounds, within the single platform allowing for an extremely portable device for a range of practical applications.

Keywords: carbon nanomaterials,electrochemistry,hybrid materials
Utilizing evolutionary interactions to limit multidrug resistance (LimitMDR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1492453.0
EU funding (EUR): 1492453.0
Participants: 1
Project status: CLOSED

Drug resistance is limiting our ability to treat most infectious diseases and forms of cancer. Indeed this relentless evolution is the major driver of treatment failure for diseases that are responsible for over half of the global disease related mortality. Yet, the underlying principles that guide this evolutionary response are poorly understood, in particular with regards to understanding the impact of multidrug treatment. LimitMDR will characterize evolutionary trajectories leading to multidrug resistance in response to individual and combination drug treatment through the execution of large-scale adaptive evolution experiment with two bacterial pathogens followed by genome sequencing and phenotyping. This effort will enable testing of contrasting hypotheses regarding the evolution of multidrug resistance in response to combination treatment. We will characterize the cause-and-effect of resistance and sensitivity mutations identified in our global data set and map comprehensive fitness landscapes of mutations accumulated during drug resistance evolution to understand the evolutionary dynamics underlying resistance evolution. To accomplish these bold goals we shall develop novel multiplexed methodologies enabling unprecedented scale of construction and phenotypic testing of identified mutations. While genetic epistasis is considered of key importance to resistance evolution most studies focus on mutations within an individual gene. Through the development of a novel experimental approach we shall elucidate complex epistatic interaction networks between mutations accumulated during resistance evolution. Finally, we will conduct mechanistic studies to uncover the mechanisms of collateral sensitivity. These studies will shed light on this underappreciated phenomenon, which is of critical relevance to drug discovery and the evolution of drug resistance. In conclusion LimitMDR will develop groundbreaking novel methodologies and scientific insights that will c

Keywords: antibiotic resistance,collateral sensitivity,adaptive evolution,epistasis,fitness,drug interactions,combination treatment,sequential drug treatment
Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype? (The MATRIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Sweden,Denmark
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-09-01
End date: 2026-02-28
Duration (months): 78.0
Total project cost (EUR): 1700002.0
EU funding (EUR): 1657123.03
Participants: 2
Project status: SIGNED

Obesity and its affiliated metabolic diseases pose serious public-health challenges. However, certain patient subgroups appear protected. To halt the socio-economic burden of metabolic disease, we urgently need to understand what distinguishes the Metabolically-Healthy-Lean (MHL), Metabolically-Unhealthy-Lean (MUL), Metabolically-Healthy-Obese (MHO) and Metabolically-Unhealthy-Obese (MUO) phenotypes, and which factors promote metabolic health. Inflammation has been proposed as a target, as it is a key driver of metabolic disease. However, clinical trials show limited evidence that anti-inflammatory drugs reduce diabetes. Why is that? Inflammation consists of a pro-inflammatory phase followed by a pro-resolving phase, which are regulated by different cells/pathways. This is critical to consider when attempting a therapeutic approach. Based on my preliminary data, I hypothesise that what separates MHL/MHO from MUL/MUO are not pro-inflammatory triggers, but rather the endogenous ability of individuals to resolve inflammation. Adipose extracellular-matrix remodelling appears critical, and pro-resolving lipids promote a MUO-to-MHO switch. My overall goal is to determine molecular pathways that differentiate the MHL/MUL/MHO/MUO phenotypes (Aim 1-4), and to investigate the therapeutic potential of pro-resolving lipids (Aim 5). This multi-disciplinary project combines cutting-edge techniques with state-of-the-art translational approaches. Through my unique access to human biobanks, I will generate patient-specific cell-lines and test drug-targets ex vivo. Novel bioinformatics pipelines will produce protein/lipid/metabolite fingerprints associated with respective patient groups, ultimately providing a new approach to tackle obesity-related comorbidities. My experience in the specialised field of pro-resolving lipid biology, coupled with my lab’s unique placement at a translational site, makes me the right candidate to lead this research program.

Keywords: obesity,metabolic health,inflammation,inflammatory resolution,specialized pro resolving lipid mediators,lipoxin