Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structural and mechanistic study of co-translationally interacting nascent chains (Co-coAssembly)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-10-02
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Almost all fundamental biological processes involve protein complexes and therefore, efficient folding and assembly of homo- and hetero-oligomers is critical for cellular functionality and integrity. Recent studies have shown that many protein complexes assemble co-translationally by one fully-synthesized subunit engaging another subunit that is still in nascent state (co-post assembly). An ongoing study in the Bukau lab now revealed that assembly can also occur by interaction of two partner nascent chains (co-co assembly). Co-co assembly is mostly employed for the formation of homo-oligomers and exists in all kingdoms of life.. Despite initial evidence of its existence, very little is known about the molecular mechanisms driving co-co assembly. This includes information on whether co-co assembly requires co-localization of two polysomes or can happen on one polysome.. Furthermore, it is currently unclear whether co-co interactions require preceding nascent chain folding steps and to what extent co-translationally acting chaperones coordinate the process and the impact of translation speed on co-co assembly. I propose to study mechanisms of co-co assembly using the dimeric chorismate mutase (PheA) as a representative top candidate from a high throughput screen for co-co assembling protein complexes in E. coli. Employing cryo-electron tomography, I will analyse the three dimensional arrangement of E. coli ribosomes in the context of a polysome to assess how organization of translational machinery allows co-co assembly. Moreover, I will study the co-translational cascade of folding steps of chorismate mutase by utilizing FRET on in vitro prepared nascent chains. Finally, I plan to explore the impact of co-translationally acting chaperones and translation kinetics on co-co assembly, by performing disome-selective profiling analysis in chaperone mutant cells lacking Trigger Factor and DnaK and in mutants that synthesize proteins with reduced translation kinetics.
REVOLUTIONIZING STATIONARY ENERGY STORAGE COST: Pilot Plant and Go To Market Plan For Zn-ion Rechargeable Batteries (ENERZ)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Sweden
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 2334960.0
EU funding (EUR): 1634472.0
Participants: 1
Project status: CLOSED

The global market for Stationary Energy Storage is estimated to reach a value of €26 billion by 2022, with a compound annual growth rate (CAGR) of 46.5 percent, fueled mostly by the rapid growth of Renewable Energy Sources (RES), which are dependent on energy storage technologies to be competitive despite their intrinsic intermittence. However, significant challenges remain when it comes to reaching the low-cost levels at which storage technologies combined with RES become competitive with the traditional electrical grid, while also remaining environmentally friendly. Enerpoly’s Zinc-Ion battery cell technology represents a breakthrough in Stationary Storage, by offering a simple, environmentally friendly, efficient, durable and low-cost alternative to Lead-Acid and Lithium-Ion batteries- today’s most widely used storage technologies. Besides storing renewable energy, Enerpoly’s technology can be used in many uninterrupted power supply (UPS) applications at grid, industrial, commercial and even residential levels. Some examples are peak shaving, datacentres, powering telco equipment and commercial and residential storage of renewable energy. ENERZ, Enerpoly’s main product, will allow battery manufacturers to reduce their current costs by more than 50% for the same kWh storage capacity when compared to Lead- Acid and Lithium-Ion batteries, with a longer cycle life and improved safety. Thanks to this project, our revolutionary technology will enter the market in 2022 in collaboration with leading European battery manufacturers.

Keywords: energy storage,battery technology,cell technology
Enabling Future Arrays in Tidal (EnFAIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Germany,Belgium,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Scaling up in the ocean energy sector to arrays (H2020-LCE-2016-RES-IA, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 20204450.0
EU funding (EUR): 14914599.5
Participants: 14
Project status: SIGNED

In this flagship project, the EnFAIT (Enabling Future Arrays in Tidal) Team, a partnership of leading European companies, will demonstrate a grid-connected tidal energy array that: - demonstrates a step change in the lifetime cost of energy for tidal power; - proves that high array reliability & availability can be achieved with best practice maintenance regimes; - captures and disseminates substantial learning on fundamental issues for the ocean energy industry; - builds investor confidence; - takes a huge step towards creating a commercial, bankable tidal energy sector; and - at 6 turbines, will be the largest number of devices ever deployed in an ocean energy array. This project will build upon an existing operational site, minimising development risk and allowing the generation of real-world results from day one. The technology used in the array has 100% EU content. The layout of the turbines will be adjusted within the project, enabling array interactions and optimisation to be studied for the first time at a real tidal energy site.

Keywords: tidal,marine renewables,turbines,renewable energy,green energy,clean energy
Intelligent Hydraulic Systems Enabling Service Business in Heavy Transport (IntelServBus)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Poland,Finland
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 1589884.5
EU funding (EUR): 1112919.0
Participants: 2
Project status: CLOSED

The project transforms manufacturing driven SME supplying components to heavy transport and mobile machinery industry to an innovation driven SME gaining significant new turnover from value added services. Hydraulic power systems are essential technology in several fields such as transport and machinery due to their unsurpassed power density. There is a trend towards subcontracting the components among the vehicle and machinery manufacturers with strategic and long-term subcontracting relationships. Still, there is a 25% per year increase in the imports of hydraulic cylinders alone to EU. Hydroline Ltd. is a family owned SME that has been successful in its business providing hydraulic components for mobile machinery but it's looking forward to take the next step in business development. The success of the company so far has been based on design and manufacturing prowess, close customer relations and continuous company development. Intensifying these strengths will stave off the price pressure at low-end market segment caused by non-EU competition. However, maintaining the growth path of the company will require generating and developing new opportunities. That requires development of proprietary technologies and IPR, products based on those, and even closer relationship with the customers. The objectives of the proposal comprise of product development based on Hydroline’s filed patents and pre-patent innovations. In particular, the product development activities are development of 1. intelligent, networked hydraulic cylinder to be used in system components. 2. integrated preventive maintenance system enabling value added services sales. 3. novel suspension kit based on the intelligent cylinder. and refinement of 4. innovation for energy harvesting. 5. innovation for local pressure increase in an actuator. The partners are Hydroline Oy and Hydroline Poland Sp. Zo. o. This core consortium is supported by subcontractors.

Keywords: tranportation,hydraulic actuators,intelligent components,service business
Improvement of bacterial lipid rafts to produce biofuels (SuperFlotillin)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

We aim to convert an industrial waste product (glycerol) to an environment-friendly biofuel (biobutanol), by using a competitive and efficient system, based on bacterial lipid rafts with gain of function mutants of flotillin, their main scaffold component. Bacterial cells can be used as hosts for biosynthesis of a variety of value-added products as antibiotics or vitamins. The use of recently discovered bacterial lipid rafts to confine the reactions is expected to greatly improve the production levels, when comparing with traditional systems. We will now further improve the yields of synthesis by generating gain of function mutants of B. subtilis flotillin (FloA), a key-role player in lipid rafts scaffolding. These Superflotillins or Flo* will organize more stable, robust and functional rafts. Therefore, they will confine more complex biosynthesis pathways with more enzymes and improve the production yields. We will then test the efficiency of these improved mutants in biosynthesis of biofuels. Five Clostridium spp. enzymes confined in B. subtilis Flo*-rafts will produce biobutanol, an alternative for traditional petroleum, using glycerol waste as a unique carbon source. After the metabolic optimisation of the process, together with our industrial partner (Enantis, CZ) we will scale up the production and assess the project viability for biobutanol production at industrially relevant conditions.

Keywords: bacterial lipid rafts,membrane microdomains,flotillin,biofuels,industrial application of bioprocesses,applied microbiology,synthetic biology,systems biology
The 19th century chromatic turn - CHROMOTOPE (CHROMOTOPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: France,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 1884867.0
EU funding (EUR): 1280375.0
Participants: 2
Project status: SIGNED

CHROMOTOPE will offer the very first analysis of the changes that took place in attitudes to colour in the 19th century, and notably how the ‘chromatic turn’ of the 1850s mapped out new ways of thinking about colour in literature, art, science and technology throughout Europe. Britain’s industrial supremacy during this period is often perceived through the darkening filter of coal pollution, and yet the industrial revolution transformed colour thanks to a number of innovations like the invention in 1856 of the first aniline dye. Colour thus became a major signifier of the modern, generating new discourses on its production and perception. This Victorian ‘colour revolution’, which has never been approached from a cross-disciplinary perspective, came to prominence during the 1862 International Exhibition – a forgotten, and yet key, chromatic event which forced poets and artists like Ruskin, Morris and Burges to think anew about the materiality of colour. Rebelling against the bleakness of the industrial present, they invited their contemporaries to learn from the ‘sacred’ colours of the past – a ‘colour pedagogy’ which later shaped the European arts and crafts movement. Building on a pioneering methodology, CHROMOTOPE will bring together literature, visual culture, the history of sciences and techniques and the chemistry of pigments and dyes, with high-impact outcomes, including one major exhibition at the Ashmolean Museum, a thorough pigment analysis of Burges’s Great Bookcase and the creation of an online database of 19th century texts on colour. This project will not only give invaluable insight into hitherto neglected aspects of 19th century European cultural history, it will also reveal the central role played by chromatic materiality in the intertwined artistic and literary practices of the period. This will in turn change the way the relationships between text and image, as well as the materiality of the text itself, may be envisaged in literary studies.

Keywords: colour,polychromy,pigments,dyes,chemistry of colour,victorian literature and painting,arts and crafts,material studies,text and image studies,reception studies,gender studies
Creation Of new value chain Relations through novel Approaches facilitating Long-term Industrial Symbiosis (CORALIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Italy,Italy,Austria,Austria,Spain,Spain,Spain,Italy,Italy,Italy,Spain,Spain,Türkiye,Sweden,Türkiye,Sweden,Greece,Sweden,Sweden,Belgium
Call: Tapping into the potential of Industrial Symbiosis (H2020-LCCI-2020-EASME-singlestage, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 22724166.25
EU funding (EUR): 17987565.27
Participants: 33
Project status: SIGNED

Industrial symbiosis (IS) has gain great attention in the last years due to its high potential for energy and resources savings. However, there is still a need for enhancing the knowledge base for IS in Europe, especially in what regards to the implementation and operation phases, which must be supported by harmonised frameworks and data reporting structures that ensure data accuracy and comparability in existing and new IS initiatives. Under this framework, CORALIS has been designed as a demonstration project for the generation of real experiences on the deployment of IS solutions and the overcoming of the barriers faced by these initiatives. In order to properly address this complex issue, CORALIS will address three factors (technical, managerial and economical) that will set the basis for the definition of the IS readiness level, a useful indicator establishing the feasibility of the overall IS initiative. In addition to specific developments on each of these factors, CORALIS will provide a harmonised framework for the monitoring of results and evaluation of their impact from a life cycle perspective. This impact assessment methodology will be implemented into a virtual assessment platform that will support the operation of the involved industrial parks. The overall approach of CORALIS will be demonstrated in a total of 3 industrial parks, each of them supported by an IS facilitator, a neutral actor in charge of guiding the IS initiative and exploiting its full potential. Moreover, 3 additional industrial parks will follow the project results in order to replicate them by implementing additional IS initiatives after the project’s end. Further replication is expected by gathering the project results in CORALIS Handbook for supporting the implementation of IS, by providing recommendations on regulation and standardization and by establishing a continuous dialogue with main European stakeholders following an ambitious dissemination and exploitation strategy.

Keywords: industrial symbiosis,is facilitator,co2 utilization,waste heat recovery,circular economy,wastewater
Market maturation of a packaging concept for sustainable and resource efficient food packaging (ecoSave)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-11-01
End date: 2019-12-31
Duration (months): 26.0
Total project cost (EUR): 2987541.25
EU funding (EUR): 2091278.88
Participants: 1
Project status: CLOSED

The growing importance of sustainability – interlinking social, economic and environmental considerations – and logistics in the food and drinks supply system mean that packaging has become a key interface of this industry. Additionally, in the increasingly competitive retail landscape, differentiation and product standout is growing more important. This result in fierce competition among retailers and brand owners, leading to a strong focus on packaging cost, environmental sustainability, quality and attractive merchandising displays. However, until now, the increase of functional and environmental performance and appearance has invariably resulted in higher costs creating a business opportunity to a packaging concept that could present sustainable principles and goals whilst addressing cost, performance and market pressures. EcoSave Packaging (ESP) aims to pursue this market opportunity by bringing to market its innovative packaging material and patented assembling process that successfully address all aforementioned needs. The ESP’s assembling method and the ESPack material technology allow several key advantages and value propositions: i) 25-50% lower cost; ii) 30-70% lower environmental impact; iii) better barrier properties; iv) attractive touch-sense; v) high-quality printing options; vi) reduced transportation and storage costs; vii) higher stack pressure; viii) significant less drop damage. ecoSave project is expected to significantly enhance the profitability of ESP, with expected revenue of €73M and profits of €15M, 5 years after commercialization. Moreover, the successful achievement of ecoSave objectives is expected to assist Europe in achieving objectives to secure resource efficient eco-innovative food processing. This project will therefore entail increased competitiveness for the SME value chain and for the EU as a whole.

Keywords: packaging material,resource efficient,cost effective,environmentally sustainable,high printing quality,top barrier properties
Mechanical and Electrical Guidance of Collective Cell Migration in vivo (MOVE_ME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1812125.0
EU funding (EUR): 1812125.0
Participants: 1
Project status: SIGNED

Directional collective cell migration (dCCM) is key for cellular clusters to reach their target tissues in embryogenesis, tissue repair, and metastasis. Though cells interact with chemical and physical cues when migrating in vivo, the field has mostly focused on studying the chemical guidance (chemotaxis) of dCCM- and the role of physical cues is underappreciated. As chemotaxis is not sufficient to explain dCCM in native contexts, the mechanisms that guide dCCM in vivo remain unclear. Thus, our overall goal is to challenge the classic chemocentric view by addressing whether and how biophysical cues such as mechanical and electrical signals contribute to dCCM in vivo. To tackle this challenging aim, we will study durotaxis (mechanical guidance) and electrotaxis (electrical guidance) at two levels: i) Tissue level, to map mechanical and electrical properties in vivo and test their relative contribution to dCCM and ii) Cellular level, to explore the mechanisms by which cells respond and integrate these biophysical cues. To address this, we will take advantage of the innovative toolbox we developed to study mechanical and electrical cues in vivo. As dCCM occurs in different biological contexts, we propose to generalise our results by studying dCCM of Xenopus neural crest (NCs) in embryogenesis (WP1, WP2), and the migration of the recently discovered Regeneration Organizing Cells (ROCs) in Xenopus tail regeneration (WP3). Demonstrating durotaxis and electrotaxis in vivo has proven to be a challenging goal. Thus, we expect our research to be a breakthrough across fields, bringing new perspectives and tools to study the biophysics of dCCM in vivo for the first time. Finally, this proposal will open new research avenues for my lab and for the field, in which the interplay of biophysical and biochemical cues from the environment could be studied, paving the way to the formulation of a novel and more integrative view of dCCM, and other cell and developmental processes.

Keywords: xenopus,collective cell migration,directional migration,biomechanics,bioelectricity,embryo development,chemotaxis