Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
In vivo gut-brain optogenetic endomicroscopy for digestive disorders management (NeurO-GI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland,France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 1526438.0
EU funding (EUR): 1526438.0
Participants: 2
Project status: SIGNED

Proper functioning of the digestive system depends largely on the enteric nervous system (the gut’s brain), which on one side is linked to the gut’s microbiota and on the other side is linked to environmental factors, like stress, via gut-brain axis. Communication along this axis is not very well understood, even though it is crucial for the diagnosis and treatment of functional digestive disorders, which are the most common problems in the digestive system imposing a significant burden on public health. One of the limiting factors is the lack of tools enabling investigation of gut’s neuronal network in vivo. The goal of this proposal is to provide an insight into the functioning of microbiota-gut-brain axis in vivo. We will develop a novel optogenetic endomicroscope based on Optical Coherence Tomography (OCT) capable of mapping the morphology and the functionality of the enteric nervous system and microbiota sampling. We hypothesize that such tool, in addition to direct analysis of the gut status in various digestive conditions, can also be indirectly used to stimulate the brain response via gut-brain axis. To test our hypothesis, we will co-register performance of the proposed method with functional magnetic resonance imaging to investigate in animal models 1) the response of the brain to activation of serotonin neurons in the gut and 2) the response of the gut to optogenetically induced depression at the brain level. Any tool improving understanding of interactions between microbiota, gut and brain would be of paramount importance for improving management of many patients with digestive disorders. Moreover, such information has potential to introduce novel diagnosis and treatment paradigm in obesity, and other diseases like Parkinson disease or Alzheimer disease. With the ultimate goal of transferring our finding into humans, we will be focused on finding OCT-specific designs and biomarkers for diagnosing diseases linked to dysfunction of this axis.

Keywords: nurogastroenterology,optical coherence tomography,optogenetics,optrode,gut brain axis,microbiota,inflammatory bowel disease,functional digestive disorders,motility,diagnosing and treatment
Future Formulations: Developing Future Pharmaceuticals Through Advanced Analysis and Intersectoral Exchange (FutForm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Netherlands,Portugal,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-04-01
End date: 2020-03-31
Duration (months): 48.0
Total project cost (EUR): 414000.0
EU funding (EUR): 414000.0
Participants: 4
Project status: CLOSED

The estimated cost of getting a new medicine to market is now in excess of $2.6 billion, with an additional $300 million (approx.) typically being directed towards post market approval research and development activities (including testing of new indications, new formulations and new dosage strengths and regimens) (Nature Reviews Drug Discovery 13, 877 (2014)). These costs have increased >145% since 2003, and reflect an increasingly complex process in which there remains a high chance of failure in the expensive later phases of development. With the aim of reducing the times and costs associated with medicine development, increasing attention has focused on the development of approaches to better predict and/or optimize the behaviour of actives and their formulations at an earlier stage of development. Recent research within the School of Pharmacy (University of Nottingham (UoN)) has focussed on the application of advanced surface analytical and biophysical tools to address this need. This proposal will build on this activity via an intersectoral researcher exchange program focussed on supporting future pharmaceutical formulations development. The principal objective of FutForm is to translate the advanced analytical approaches developed within UoN, so that they become embedded into industrial practice for the development of future pharmaceutical processes and therapies. This will be achieved through a collaborative programme of researcher secondments with three small-medium enterprise (SME) companies, each with early stage innovative technologies in areas of importance to the future pharmaceutical industry, namely; enzyme formulations for improved cell isolation (Abiel s.r.l; Italy), nanoparticle platform formulations for oral and topical drug delivery (Inovapotek, Pharmaceutical Research and Development Lda; Portugal) and hydrogel formulations for cell-delivery (Hy2Care b.v.; Netherlands).

Keywords: pharmaceutical formulations,drug delivery,cell delivery,pharmaceutical materials characterization
Developing and Testing the Psychological Distance to Science Model (PSYDISC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Increases in science scepticism among the public represent one of the key societal challenges of the 21st century. Recent research has made some progress by identifying variables that contribute to science scepticism. However, there are two important limitations to the current state-of-the art. One is that the antecedents identified so far have limited explanatory power, leaving substantial unexplained variance. The other is that these antecedents are unmalleable (e.g., religiosity, ideology), so that although it is possible to—to some extent—predict science scepticism, structural and theory-informed ways to understand and change scepticism are not yet identified. To overcome these limitations, I propose a Psychological Distance to Science model (PSYDISC), which states that perceiving science as psychologically distant is a crucial antecedent of science scepticism. This project will move research on science scepticism beyond the state-of-the-art in two ways: 1) PSYDISC will structurally explain unique variance across various topics of science scepticism; 2) the project will provide experimental evidence for the effects of psychological distance to science, and so identify empirically-based ways in which levels of science scepticism can be reduced. 1.PSYDISC will be tested by assessing as well as manipulating psychological distance to science. 2.This will be done by utilizing a multi-method approach that includes large-scale surveys, controlled experiments, randomized longitudinal studies, and secondary data analysis. 3.Various high-quality samples from around the world will be used to this end. 4.Previously identified predictors of scepticism will be controlled for in order to gauge the unique explanatory power of PSYDISC. PSYDISC will provide a much-needed theoretically informed account of science scepticism and so provide the basis for a long-term research agenda aimed at drastically increasing our understanding of the psychology behind science scepticism.

Keywords: attitudes and beliefs,social psychology,science scepticism,stereotyping,ideology,generalizability,political psychology,climate change beliefs,vaccination hesitancy,construal level theory,psychological distance
High performance sustainable bio-based packaging with tailored end of life and upcycled secondary use (PRESERVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Spain,Germany,Italy,Germany,Germany,Spain,Italy,Italy,Belgium,Slovenia,Belgium,Belgium,France,France,France,Czechia,United States,Netherlands,Luxembourg,United Kingdom
Call: Upcycling Bio Plastics of food and drinks packaging (RIA) (H2020-NMBP-TR-IND-2020-twostage, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 7999576.25
EU funding (EUR): 7999576.25
Participants: 28
Project status: SIGNED

PRESERVE aims at boosting the circular use of bio-based packaging. To shift from the current situation (fossil-based, limited recycling), we build on award-winning upcycling strategies from past and on-going projects. We will enhance the performance of primary food packaging via bio-based barrier coatings for bioplastic and paper/board substrates, as well as via eBeam irradiation and microfibrillar-reinforcement. From the biotechnological side, we will leverage the compounding of enzymes in bioplastics to stimulate biodegradation, the enzymatic recovery of functional oligomers and the delamination of multilayer packaging via enzymatic detergents to enable their layer separation and recycling. The processes required to produce at least 10 packaging demonstrators will be upscaled. The enhanced bio-packaging will be validated with different types of food and drinks. Recovered biopolymers will be upcycled in added value applications such as packaging for personal care products and reusable carrier packaging (using textiles and composites). The versatility of our end of life options, materials, flexible and rigid packaging types and compatibility with different processes, ensure that PRESERVE results are relevant to more than 60% of the plastic packaging on the market, which long term substitution potential will be maximised thanks to the participation of several leading companies in the consortium. Our 2030 roadmap will outline the pathways to significantly influence the emergence of bio-based packaging and create jobs and growth in the sector. To widen PRESERVE impact, we will also perform life cycle and safety assessments, user acceptance studies and contribute to standardisation and certification. All in all, by contributing to the EU Plastics Strategy in a circular economy, our PRESERVE circular renewably sourced packaging solutions and derived upcycled applications will not only optimally preserve the food and drink but also our environment and its finite resources

Keywords: bioplastics,paper,multilayer,flexible,rigid packaging,barrier properties,recycling,upcycling,enzymes,microfibrilar reinforcement,ebeam,coatings,adhesives,textiles,composites,food,drink
Designed catalysts for tandem reactions – insertion of Lewis acid centres into the framework of layered double hydroxides for catalytic applications (Lewis acid insertion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Australia,Hungary
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-08-31
Duration (months): 30.0
Total project cost (EUR): 213530.4
EU funding (EUR): 213530.4
Participants: 2
Project status: SIGNED

The scope of this project is to find out how could valuable organic molecules be synthesized in a more efficient, more economically friendly way than the currently applied technologies offer. The answer may be the designed catalysis. The well-known layered double hydroxides (LDH) and their composites are suitable for offering solutions for different catalytic problems. Numerous materials belong to this group of chemicals. They are widely used as catalysts, their catalytic application is usually based on the advantageous properties of their building components or the general properties of the material itself. By the insertion of catalytically active Lewis acid centres such as Ag(I), Bi(III), Au(I), Zr(IV), Sn(IV) or Hf(IV) into the framework of the hosts via the metal ion direct or mechanochemically assisted co-precipitation or polyoxometalate intercalation, the main aim of our work is to develop multifunctional catalysts on the basis of LDH. In certain cases the structure of the LDH can be easily modified giving the possibility to design catalysts to a specific reaction by installing different functions/functional groups into the initial structure. By combining certain types of catalysts (forming hybrid structures) and applying them as tandem catalysts, “one pot” syntheses of complex organic materials could possibly be accomplished. To carry out the most efficient tandem reactions with green chemically approach, the project will be largely focused on the exploration of structure–activity relationships. All of the most relevant factors (porosity, dimensionality, hydration, effects of counter ions or hosts) are being systematically investigated to maximize the efficiency of the catalysts in the chosen reactions. Obtaining deep knowledge from the prepared hybrid materials and their catalytic properties, on the basis of well-characterized catalysts, feasible tandem reactors and/or tandem flow reactor for the chosen reactions will be planned.

Keywords: lewis acid centres,layered double hydroxides ldh,tuneable acid base character,tandem reactions
Futures 2020 (FUTURES2020)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-01-31
Duration (months): 8.0
Total project cost (EUR): 218603.75
EU funding (EUR): 218603.75
Participants: 4
Project status: CLOSED

FUTUREFUTURES 2020 is an ambitious and dynamic programme of events designed to deliver the EU Commission's objectives. A consortium of five universities from across the South West UK have teamed up with world-class venues and heritage attractions to deliver the largest celebration of contemporary research in the region, both in terms of audiences and participating researchers. FUTURES 2020 will reach out to citizens of the large cities of Bristol, Bath, Exeter and Plymouth as well as rural areas of Wiltshire, Somerset and Cornwall. Events will provide direct contact with researchers and showcase the results of contemporary research and its impact on people’s daily lives. We are mounting an ambitions awareness raising campaign, aiming to reach a million people through a variety of methods. We are utilising all our partners' expertise and networks to make this a memorable European Researchers' Night in the last year of H2020. A programme of 23 activities will involve over 300 researchers directly interacting with audiences in innovative and engaging formats. Underpinned by principles of inspiration, invention, inclusivity, fun, learning, and discovery the events will demystify research and innovation, showing their value for individuals and societies locally and globally with celebratory EU Corners at each flagship venue. We have a strong emphasis on engaging school children and families to increase awareness of careers in research and to break stereotypes about researchers. We are also tailoring activities for disadvantaged groups who may not normally have access to research or researchers. Sound management by experienced partners, who have a track record of successful multi-partner projects, with a carefully constructed budget, clarity of roles, significant in-kind contribution from all partners, and an independently conducted evaluation using a mixed methods approach, will ensure that the project is successful in reaching its objectives and good value for money.

Keywords: futures 2020,south west,bristol,bath,exeter,plymouth
Energy-Efficient Activated Sludge Monitoring for Wastewater Treatment Plants (SHEPHERD)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 2508750.0
EU funding (EUR): 1756125.0
Participants: 1
Project status: CLOSED

The aeration of activated sludge accounts for 60% of the running cost of wastewater treatment plants, a staggering 2% of all electricity generated at country-level. The project will improve upon an existing prototype of on-line microbial respirometer with near real-time capability for monitoring the activity of the microbial population (biomass) in activated sludge, and suitable for industrial and municipal wastewater applications, with the following environmental and financial benefits: • 20% reduction of greenhouse gas emission related to the aeration process (lower energy consumption) • 5% reduction of nitrous oxide emission related to the denitrification process (better process parameters) • 25 % reduction of energy costs and maintenance costs (better online monitoring of the process) The solution reduces the costs and improves the reliability of the measurements, allowing small and midsize WWTPs to monitor the biological activity of the process. The integration with existing hardware sensors and SCADA systems, allows the system to control the plant automatically within design operating parameters and reacting in real-time to variable (diurnal and seasonal) loading or toxic events. The cloud-based implementation creates a central data repository accessible for operational purposes (remote access, alerts) and management purposes (benchmarking, continuous improvement, and design of new installations). The original prototype (TRL6) was tested in Anglian Water’s Milton (Cambridge) wastewater treatment plant and gave operators information about the status of the active component (biomass) so that manual interventions could be made to improve efficiency. The project aims to take the technology forward, automate the process to a higher degree and demonstrate the solution in a large-scale pilot with four wastewater utilities over 10 plants across Europe and the USA (TRL 8). The project duration is 24 months and the requested EC funding 1.75M Euros.

Keywords: activated sludge,closed loop monitoring,wastewater,microbial respirometer
(Un)Just Neighbourhoods Socio-Spatial Justice in Urban Neighbourhoods (Justhood)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-10
End date: 2021-01-09
Duration (months): 36.0
Total project cost (EUR): 269857.8
EU funding (EUR): 269857.8
Participants: 2
Project status: CLOSED

Rapid urbanisation, growing process of globalisation, and the neoliberal hegemony have culminated in the omnipresence of socio-spatial inequalities at the neighbourhood scale regarding racial segregation, deprivation, stigmatisation, and degradation. European and North American cities, among others, have initiated neighbourhood-oriented urban redevelopment schemes to mitigate the burden of urban injustice. However, there is no integrated framework to evaluate their achievements, the contribution of urban neighbourhoods to just cities has not been systematically investigated. To address this lacuna, the project conceptualises the idea of (un)just neighbourhoods from socio-spatial justice perspective and develops an evaluation framework for measuring key qualities of socio-spatial justice at the neighbourhood scale. The project employs a methodological bricolage approach to address its interdisciplinary nature. It first theorises (un)just neighbourhoods from two perspectives of intra-neighbourhood and inter-neighbourhood socio-spatial justice. It then proposes an integrated framework, consisting of a set of principles, indicators, and measures, for evaluating neighbourhood-oriented redevelopment schemes. Focusing on two neighbourhoods of Bayview-Hunters Point (San Francisco) and Fruitvale (Oakland), the research critically reflects on the constructed storytelling around socio-spatial justice imposed by the local authorities. The proposed evaluation framework is applied to the case study neighbourhoods through intensive fieldwork to explore whether and to what extent the implemented redevelopment schemes have enhanced socio-spatial justice of the neighbourhoods, or re-produced existing socio-spatial injustice, in both process of interventions and their outcomes. Finally, using recent achievements in digital ethnography, the project documents alternative paths and stories towards achieving greater urban justice practiced by the community coalitions and grassroots.

Keywords: just neighbourhoods,socio spatial justice,just city,urban redevelopment,alternative practices