Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genomic & Epigenomic Complex Disease Epidemiology (GEOCODE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom,United Kingdom,United Kingdom,France,Italy,Netherlands,Spain
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2010-03-01
End date: 2014-02-28
Duration (months): 48.0
Total project cost (EUR): 772200.0
EU funding (EUR): 772200.0
Participants: 8
Project status: CLOSED

Genetic and epigenetic epidemiology are rapidly developing aspects of population-based health research that have clear translational potential. These endeavours both benefit considerably from extensive international collaborations. Establishing robust associations between genetic variation and common complex disease phenotypes requires very large sample sizes than can only realistically be generated through collaborative work. Furthermore, exploring associations in populations with different historical origins contributes to location of functional variation. Interactions of genetic variation and environmental exposures are best studied against a background of widely different environments, something that is best leveraged between, rather than within, countries. Epigenetic patterns are clearly influenced by exposures such as 1-carbon composition of the diet that differ between countries, allowing considerably greater power for establishing associations. Triangulating environmental exposures, genetic variation and epigenetic mediation offers to provide a step-change in ability to detect causal associations, of direct relevance to therapeutic and preventive activities. GeoCoDE will assemble a group of investigators who are custodians of world-leading population resources, have access to appropriate technologies and have been involved in advancing methods of data analysis. Through exchange visits of senior and junior research staff, workshops and extensive networking we will contribute to major advance in European capacity in this field.

Keywords: epidemiology,genetics,epigenetics,genomics,epigenomics,mendelian randomization,birth cohorts
Cooling, AGN Feedback and Evolution in Groups (CAFEGROUPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Italy
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 133200.0
EU funding (EUR): 133200.0
Participants: 2
Project status: CLOSED

This proposal aims to facilitate close collaboration between researchers in the UK, Italy, USA and India to study the nature and consequences of the energy transferred from supermassive black holes at the centres of galaxies to the surrounding intergalactic medium (IGM) in groups of galaxies. The research combines data from opposite ends of the electromagnetic spectrum: low-frequency radio observations track the history of outbursts from the black holes, while X-ray data allow us to determine their effects on the ten-million-Kelvin gas of the IGM. The partner institutions have long records of internationally-recognised research in these areas. The University of Birmingham is one of the top few teams worldwide in the study of groups with a solid track record in X-ray astronomy (particularly using ESA's XMM-Newton X-ray observatory), while the INAF-Istituto di Radioastronomia provide access to some of Europe's best experts in the low-frequency radio regime. The Smithsonian Astrophysical Observatory (US) is the home of NASA's Chandra X-ray observatory, and has a strong claim as the preeminent X-ray astronomy institution worldwide, while the National Centre for Radio Astrophysics (India) operates the Giant Meterwave Radio Telescope (GMRT), the first and currently the only radio observatory to achieve high spatial resolution and sensitivity at low frequencies. The collaboration will bring together experts with diverse skills to study closely one of the outstanding puzzles of modern astrophysics, providing direct benefits to the European institutions involved, the wider scientific community, and to the European Research Area as a whole, through increased scientific returns from current European facilities, increased access to international resources, and the scientific and theoretical tools for wide range of future studies with Europe-based facilities (e.g., the European LOFAR radio observatory and ESA International X-ray Observatory).

Keywords: astronomy,astrophysics,cosmology,extragalactic,radioastronomy,x-ray astronomy,galaxy groups
Land Use Modelling and Analysis Network (LUMAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,Belgium
Call:  (FP7-PEOPLE-2009-IRSES, 2009)
Start date: 2010-11-01
End date: 2014-10-31
Duration (months): 48.0
Total project cost (EUR): 77400.0
EU funding (EUR): 37800.0
Participants: 2
Project status: CLOSED

The Land Use Modelling and Analysis Network aims to co-ordinate and consolidate the research efforts of three organisations involved in land-use modelling and analysis and to animate the aspirations of the European Research Area. This 4 year programme of exchanges of early stage and experienced researchers will enliven a research area with considerable capacity for intellectual innovation and with wide applicability to real-world problems faced by regional administrations, such as resource management and spatial planning which occurs in many territories around the world.

Keywords: natural sciences,geography,natural resources management,ecology,modelling tools,physical sciences,biodiversity
Simultaneous Elemental and Molecular Imaging of Biological Targets – A New Paradigm for the Study of Disease and its Treatment (BIOMAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2012-03-13
End date: 2014-03-12
Duration (months): 24.0
Total project cost (EUR): 210092.8
EU funding (EUR): 210092.8
Participants: 1
Project status: CLOSED

This project proposes the development of a technology capable of delivering, high speed, simultaneous elemental and molecular maps of biological targets. Specifically these targets will include plaques associated with age-related macular degeneration (AMD), tumours treated with Pt-based chemotherapy drugs, and cell populations derived from the FP7 project, the ONE Study. The dual-mode imaging system will enable the analysis of metallo-proteins and their binding sites, or where there is no native metal tag or its abundance is too small to detect, anti-body or specific reactive chemistry metal or nano-particle tags will be added to the target molecules. For the ONE Study, one of the key project aims is to develop cell labelling strategies that will enable therapeutically administered cells to be tracked at low abundance in the host cell populations without toxic impact on either the therapeutic cells or host organism. The technology will be based on employing a common pulsed laser platform for laser ablation, desorption, or matrix assisted sampling of the target material simultaneously coupled with inductively-coupled plasma elemental mass spectrometry (ICP-MS) and ion trap organic mass spectrometry. In the case of the molecular mass spectrometry, electro-spray or matrix assisted charging will be used. The sampling will employ a technology developed in the host laboratory that enables targets to be sampled at atmospheric pressure whilst excluding atmosphere from the sampling point. The technology will be optimised for high speed and high efficiency to enable rapid mapping of targets at very high sensitivity. This will require development of a new high efficiency torch design for ICP-MS and the novel use of micro-jet pumps to deliver samples to the mass spectrometers. The project will also take advantage of the Fellow’s expertise in synchrotron X-ray techniques to obtain non-destructive and comparative analyses of the specimen materials.

Keywords: biomedical imaging,proteomics,metallomics,analytical science,mass spectrometry,inductively-coupled plasma mass spectrometry,laser ablation,laser desorption,cell labelling
Ionisation of aligned atoms and molecules by low energy electron impact (ALIGNED E2E)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-10-24
End date: 2013-10-23
Duration (months): 24.0
Total project cost (EUR): 202049.6
EU funding (EUR): 202049.6
Participants: 1
Project status: CLOSED

Low energy ionising electron collisions with atoms and molecules have an impact on a range of phenomena and applications, since it is in this energy regime that ionisation is most likely to occur. As an example, these collisions are important in understanding the Earths upper atmosphere, in creating new energy efficient lighting and in the accurate targeting and treatment of cancers by radiotherapy. For these fields to progress it is essential to understand the physics governing the interactions at a fundamental level. By developing detailed theoretical models, it is then possible to predict the effect of the collision in different areas. To develop these models, precise data from sophisticated experiments are needed to evaluate their accuracy. The coincidence experiments proposed here provide the most detailed way to assess this. In this program, new experiments will be conducted from atoms and molecules over a wide range of geometries. A comprehensive suite of data will be obtained for comparison to models being developed by theoretical collaborators throughout the world. Molecules to be studied include those of technological, environmental & medical importance. To further this understanding, new experiments will measure ionisation from ALIGNED atoms and molecules for the first time. In conventional experiments the targets are aligned in random directions, and so theory must make approximations to describe this. At present, this often results in a poor comparison between theory and experiment. By aligning the targets prior to the collision using laser beams, or by determining their alignment after ionisation (both of which will be employed here), it becomes possible to rigorously compare theory & experiment with unprecedented detail. It is the aim of this research to carry out these challenging experiments for the first time in this important energy regime.

Keywords: physical sciences,atomic physics,molecular physics,electron impact ionisation,aligned atoms,aligned molecules,laser-atom interactions
A multidisciplinary approach for the computational assembly of large molecular machines from electron density maps (MOLECULAR ASSEMBLY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-06-01
End date: 2013-05-31
Duration (months): 24.0
Total project cost (EUR): 162242.4
EU funding (EUR): 162242.4
Participants: 1
Project status: CLOSED

Proteins are often organized in large, dynamic molecular machines. A mechanistic, atomic-resolution understanding of these machines would provide fundamental insights into the clockwork of the complex machinery underlying human life. However, machines such as the 26S-proteasome have resisted crystallization attempts for decades. Cryo-electron microscopy (cryo-EM) has provided insightful maps of molecular machines, but these lack atomic resolution. In principle, molecular machines can be assembled from atomic homology models of the subunits. However, homology models often contain large errors, causing existing assembly methods to fail. Here I present a multidisciplinary approach for the assembly of large molecular machines from cryo-EM maps. I will combine computational techniques from cryo-EM, homology modelling and interface prediction into ATTRACT, the only docking method that integrates subunit flexibility into the initial search. Driven by a cryo-EM density map, ATTRACT’s coordinated motions will reduce the initial homology model errors, bending the subunits into the correct shape while they are being assembled. The challenging nature of the problem requires the integration of approaches. After firm assessment of the abilities of the method, it will be applied to experimental density maps of the proteasome and other molecular machines, providing new fundamental insights when neither complex nor subunits are known.

Keywords: multidisciplinary molecular machines,cryo-electron microscopy,docking,homology modelling,interface prediction
Beyond National Models? Managing Immigration and Integration in Systems of Multi-level Governance – a transatlantic comparison (MIGRATION POLICY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-03-01
End date: 2012-02-29
Duration (months): 12.0
Total project cost (EUR): 109372.5
EU funding (EUR): 109372.5
Participants: 1
Project status: CLOSED

The research project addresses the formation of immigration and integration policies in systems of multi-level governance from a comparative trans-Atlantic perspective. It investigates under what conditions and through what political processes initiatives in this critical field of the EU’s international competitiveness are successfully launched. Built on this insight and informed by the trans-Atlantic comparative perspective, the project explores successful models of managing migration and integration (best practices) and how they are linked to the political opportunities generated in systems of multi-level governance (including the increasingly important process of European integration). Based on a prior study of two Canadian provinces, two regions in Europe will be studied as in-depth case studies (North Rhine-Westphalia and Emilia-Romagna). They are located in Germany and Italy, two EU member states with significant recent changes to their immigration regimes and political systems that grant considerable political autonomy to the regional level. The Marie Curie Fellowship will be housed at Hamburg University’s Center for Global Governance (CGG), a centre of excellence in international, multi-disciplinary research on the transformation of governance in a globalizing world. The Marie Curie fellowship is designed in a way to allow for effective and sustainable forms of research collaboration and knowledge mobilization between Europe and Canada. A series of high-profile publications, presentations at European universities, joint workshops, transnational research projects, graduate students collaboration and fora of exchange between migration specialists at European and Canadian universities through pre-existing transatlantic networks are key initiatives to develop and nurture such mutually beneficial forms of transatlantic cooperation.

Keywords: social sciences,migration and integration policy,multi-level governance,regions,european integration,canada,germany,italy
Explaining EU's External Relations. Origins and consolidation of EU's policy towards Eastern Europe and Russia, 1969-1985 (ECOSTPOLITIK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-04-04
End date: 2013-04-03
Duration (months): 24.0
Total project cost (EUR): 193349.6
EU funding (EUR): 193349.6
Participants: 1
Project status: CLOSED

The research project deals with the European Community’s (EC) relations with Eastern Europe in the period 1970-1985. It explores the attempts of the EC and its member states to shape, implement, and further develop an autonomous and collective Eastern policy (Ostpolitik) as part of a more general effort at asserting a distinct political role for the EC in the international arena. Focusing on the multilateral and pan-European level, and taking into consideration the broader international context, the project will offer a historical analysis of the development of the EU’s Common Foreign and Security Policy in general, and of the determinants of EU’s enlargement towards Eastern Europe and EU policy towards Russia in particular. The project will contribute to improve our knowledge of the Cold War, of the integration process, and of Europe as a continent. It also aims at appealing to scholars of law, European politics, and International Relations, in the conviction that knowledge of the past serves a better understanding of the present and helps scholars and decision-makers respond to current challenges. The ECOSTPOLITIK is a truly interdisciplinary project. First, it will merge different historical sub-disciplines, i.e. Cold War, European integration, economic history. Second, it will discuss interpretations and theories developed by jurists dealing with the matter. Third, it will make use of theories and concepts of political and social sciences as heuristic tools to appreciate more comprehensively both the EU polity and international negotiations. I will base my research on secondary literature, memoirs, archival sources (documents), and contemporary journals, periodicals and media sources. As I conceive of this project as a truly interdisciplinary research, I will also make targeted use of law and political science literature on matters such as the use of economic means in international relations, governance, decision-making, and external relations of the EC.

Keywords: international politics and relations,contemporary history,economic history,cold war studies,eu history and politics,eu's external relations,common foreign and security policy,eastern europe,russia
Ecology of herbivore-induced leaf-to-root signaling in plants: Finding and testing the elusive messengers (SHOOT-ROOT-SIGNALING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-05-01
End date: 2014-06-21
Duration (months): 24.0
Total project cost (EUR): 162242.4
EU funding (EUR): 162242.4
Participants: 1
Project status: CLOSED

The capacity of plants to withstand insect attack is of crucial importance for their fitness. Consequently, plants have developed intricate strategies to fend off herbivores and compensate for the negative impact of leaf-removal. Phytohormones, are responsible for many of these effects and are therefore widely recognized as key messengers in plant immunity. While the changes in leaves upon herbivore attack are well understood, it is becoming increasingly clear that the plant’s reaction involves the root system as well: Plants synthesize a variety of secondary metabolites and even defensive proteins in their roots that are then transported aboveground, they increase their assimilate uptake and storage capacity belowground to optimize regrowth after defoliation, and they reduce root expansion to liberate resources for leaf-defenses. Given the fact that roots actively respond to leaf attack, signals have to travel from the site of attack to the roots to induce the observed responses. Yet, until today, not a single herbivore induced leaf-to-root signal has been unambiguously identified. This project lays out a roadmap to discover the elusive leaf-to-root messengers using Nicotiana attenuata, one of the most advanced molecular and ecological plant-insect systems available today. The signaling cascade of N. attenuata has been thoroughly characterized in the leaves, and its root system is well known to be of central importance in plant defensive processes. By combining the N. attenuata system with novel analytical and molecular approaches, this project has the potential to considerably improve our understanding of the role of roots in aboveground processes and may lead to the identification of novel within-plant signals.

Keywords: secondary metabolites (plant physiology),arthropod pathogens of plants,plant-insect interactions,phytohormones,signaling
Design of Mobile Catalytic Nanowires for Targeted Delivery of Therapeutics (NANOCOURIERS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2012-01-03
End date: 2014-01-02
Duration (months): 24.0
Total project cost (EUR): 273095.0
EU funding (EUR): 273095.0
Participants: 1
Project status: CLOSED

The overall aim of this project is to synthesise and fully characterise new asymmetric functionalised nanowires and to investigate the capability of these fascinating materials to act as therapeutic transportation tools in nanomedicine. Given suitable choice of materials these “NanoMotors” can be displaced via catalytic decomposition of a fuel which leads to self electrophoretic propulsion towards one end of the nanowire. The unique features of these nanodevices will be tested for the directed delivery of “clot buster” drug cargos. Such nano delivery systems aim to render delivery specifically to the site of disease, improving stability, loading and bioavailability of their cargos. The provision of the human infrastructure requested here with essential background knowledge and expertise will contribute towards development of this emerging area within Europe. Our findings will have an impact on related fields such as nanosensors, material science and nanomedicine. The core objectives are: 1. Synthesis of modified nanowires enabling guided motion along a predetermined pathway. 2. Full characterisation of the nanomotors using advanced surface techniques and catalytic propulsion testing. 3. Bio-conjugation studies and assessment of protein binding and release options. These objectives will be achieved using innovations and tasks involving the use of specialist resources and techniques within the physical and surface sciences, which are available at the host institution at ITT Dublin. It is envisaged that this project will facilitate key knowledge transfer from Dr. Krishnakumar Pillai (an experienced researcher from India who is working in field of nanobiotechnology) to the host institution in Ireland. The research group involved has a proven capacity to absorb, retain and exploit such knowledge by appropriate means, bringing adding value and increased potential for international collaboration via spin-off projects in related areas.

Keywords: physical sciences,nanomaterials,nanowires,drug delivery,bioconjugation