Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
L'industrie oubliée de Néandertal - The forgotten industry of Neanderthal (LION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

The development of Paleolithic sciences from the exceptional European heritage led to define the behavioral modernity on the basis of the material culture of Homo Sapiens in this part of the world. In the set of modern traits is the use of bone materials, for making fully shaped objects by means of varied techniques. The lack of bone industry by Neanderthal has been considered as a cognitive gap. However, the definition of what a bone industry should be is based on artefacts having a strong social and symbolic value, which excludes part of the equipments made by Homo Sapiens himself. Indeed, a large part of the bone industry within the Solutrean assemblages was revealed by my PhD investigations: due to the use of percussion for blanks production and tools shaping, these products were confused with the faunal remains. The transfer of my analytical grid to Paleolithic sites of the Siberian Altai, among which Denisova cave, has uncovered a diversified bone industry in occupation layers from other Hominians. My identification of more than a thousand knapped bone tools opens up new perspectives. Was the production of this industry by Denisovans and Neanderthals a local shared tradition, or is this the sign of a wider practice so far unseen by lack of appropriate analytical and conceptual tools? I propose to investigate this issue by extending the corpus to Neanderthal sites of Western Europe and by creating a traceological framework suitable for the functional recognition of the unshaped bone tools. My aim is to contribute to the debate on the cognitive faculty of archaic Humans, not so much in binary terms, as all too often discussed, but rather according to the structure of their technical world. The Traceolab, at the University of Liege, with its modern equipment, its field of competence in full adequacy with the subject and its access to archaeological collections of great value constitutes the most favourable context for the continuation of my research.

Keywords: middle palaeolithic,neandertal,bone industry,technology,traceology,experimental archaeology
Blue light remote analgesia with K+ channels (BREAK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-12-01
End date: 2021-11-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Chronic pain (CP) is a medical condition affecting around 20% of adults in Europe, characterised by an abnormal duration of pain (> 12 weeks) originally initiated by a trauma or illness. Despite significant progress, CP remains extremely hard to treat, with only one-third to two-thirds of patients reporting adequate some pain relief. This situation is even worse for neuropathic pain (NP), a specific class of CP affecting 8% of global population and whose origin mostly depend on peripheral or central nervous damage or disorder, which leads the brain to interpret as pain normally non painful stimuli. NP is difficult to treat due to the large number of entities involved (cells, genes and proteins working in synergy), which makes it hard to rapidly diagnose the exact cause of pain. Drugs targeting the central nervous system (e.g. antidepressants and opioids) provide only partial pain relief and are nonspecific, also causing side effects like addiction, and nausea, thus restraining their adoption for prolonged treatments. BREAK is the first non-invasive inhibitory optogenetic tool specifically designed for NP treatment, with potential application to the whole spectrum of CP. BREAK is composed of a drug and an optical device. The protein BLINK2 is injected in the painful area using a genetically engineered virus, and respond to a specific blue light by silencing the addressed neuron. The lamp can be kept at some distance (cm) from the skin and no implant is required. Just some minutes of treatment results in hours of pain relief, making the invasiveness of BREAK far lower than actually existing solution. A first version of BREAK has already demonstrated in in-vivo experiments on rats. During this project we plan to further develop the treatment and explore its commercial potential. In particular, leveraging from the experience of different partners, we will constitute a fruitful stakeholder network, including Academic centers, hospitals, pharma companies and investor

Keywords: neuropathic pain,ion channel,optogenetics
AI-based autonomous flight control for the electric passenger aircraft of the nearest future (Corvid)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Switzerland
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-09-01
End date: 2018-01-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In April 2017, Uber announced that it expects to deploy flying taxis in Dallas-Fort Worth, Texas, and Dubai by 2020, and will partner with diverse companies such as Bell Helicopter and Embraer to make the vertical take-off and landing vehicles (VTOLs). Same month a full-size prototype of an electric personal two-seater aircraft designed by the Munich-based company Lilium made a successful first flight. There are more than 30 companies globally now, developing VTOLs—lightweight electric flying taxis that will transform our transportation patterns in the nearest future. At the same time, qualified pilots are already in short supply. Airbus predicts that given that additional 500,000-600,000 more will be needed by 2035 to keep pace with the aviation’s expected growth, especially given the nascent VTOL market. This shortage can only be covered by further automation of flight control, making it capable of replacing the human pilots altogether. With the current approach to development of avionics software this is not possible. Daedalean is a Swiss SME started by the cross-disciplinary team of Google, SpaceX, ETH Zürich & Imperial College London alumni, which has designed the world’s first AI-based autonomous flight control system. This system is capable of passing the stringent certification tests devised for human pilots. The system will also be able to handle emergencies and unexpected situations as good as human pilots. Daedalean is aiming at servicing a 10-15% share of the forecasted €5.2bn global VTOL market, with revenues of up to €78mn by 2025 and 170+ people employed. Ultimately, Daedalean will create a tipping point for adoption of AI-based autopilots for commercial freight and passenger flights, reducing operational costs & further increasing safety of the aviation industry. In this Phase 1 project, Daedalean will run an in-depth market assessment and devise a strategy to undergo certification processes successfully in multiple EU countries.

Keywords: artificial intelligence,auto pilot,flight control,personal urban aircraft
HUMAN+ Towards expertise in enhanced human/technology experience (Human Plus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2019, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 2648160.0
EU funding (EUR): 1324080.0
Participants: 1
Project status: SIGNED

Rapid developments in information technology in the past three decades have opened up new, unfamiliar frontiers in all areas of society: culture and media, politics and security, health and wellbeing. Big data and machine learning are transforming our experience of social interaction, identity, governance, entertainment, journalism, privacy, and, through artificial intelligence (AI), what it means to be human. There are increasing calls for human-centric approaches to critical questions concerning this rapid expansion of adaptive technologies and their impact on the nature and future of humanity. Trinity College Dublin, Ireland, will address this need through HUMAN+, which will connect computer science researchers with arts and humanities researchers and enterprise to forge a human-centric approach to technological development. HUMAN+ will recruit 18 experienced researchers over 2 calls, each for a duration of two years. It will invite research proposals addressing one of two broad strands: (a) questions that consider technological developments from the humanistic perspective (b) proposals to develop technology with insights informed by the arts and humanities. Through multidisciplinary supervision, industry participation by way of workshops and mandatory secondments, HUMAN+ fellows will gain inter-sectoral experience contributing to their capacity to tackle societal challenges relating to the areas outlined above. Non-academic partners involved in the programme include Nokia Bell Labs, Accenture Human Insight Lab, EPIC- the Irish Emigration Museum, Fidelity and Ancestry.com. As part of the fellows’ training, HUMAN+ will participate in a ‘Future Lab’ which will bring the fellows together to test, learn, invent and build solutions in response to problems set by our industry leader partners. HUMAN+ is jointly developed by the Trinity Long Room Hub Arts & Humanities Research Institute and ADAPT, Science Foundation Ireland Centre for Digital Content Innovation.,

Keywords: arts and humanities,computer science,steam,ethical and societal values,human centric approaches to technology developmen,career development for early career researchers,intersectoral secondment
Let us build the first European Business-to-Business Social Network (EB2BSN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ALG is an innovative SME founded in 2010, builder of the Attestation Légale platform (http://www.attestationlegale.fr), currently in use by thousands of French businesses. The Attestation Légale platform is a Software as a Service (SaaS) Web application through which businesses can share their administrative documents and can benefit from alerts and always up-to-date documents. Because of the future implementation of a European directive that reinforces the obligation of diligence in Europe (http://www.lemoniteur.fr/165-commande-publique/article/actualite/23657764-bruxelles-adoption-definitive-des-directives-marches-publics-et-concessions), our objective and our main motivation for this project proposal are to investigate the possibility of deploying our solution on a European scale. The deployment of such a solution will lead to the following outcomes: - Improvement of the competitiveness of European businesses by the administrative simplification accelerated by the European directive; - Better regulation in the context of worker secondment and contribute to the effort on countering unfair competition between multiple European Union businesses. These outcomes will also lead to the following impacts: - Usage disruption by eliminating the redundant processes and costs related to the diffusion and the collect of administrative documents; - Technological disruption by modeling and exploiting these Business-to-Business social networks while respecting the requirement of privacy and data property specific to businesses actors; - Data governance disruption by letting the members of our platform to remain the owner of the produced data. The objectives of this phase 1 are to identify the European countries in which our solution can be deployed. If such countries are found in phase 1, the phase 2 would enable us to either prototype or modify our current solution to support these countries and to let their businesses benefit from our solution.

Keywords: social network,business to business relationships
The Complete Solution for Fast and Cost-efficient Yeast Separation Process in Production of High Quality Sparkling Wine (MySpark)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Slovenia
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-11-30
Duration (months): 8.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In only 10 years, global sparkling wine market has expanded for remarkable 40% and continues to grow rapidly, creating limitless market opportunities for sparkling wine producers. Rapid growth of the market is driven by globalization of consumption and increasing change in perception of sparkling wine from luxury, occasional product to an everyday drink. With increasing consumers’ awareness of sparkling wine quality standards, a particular growth is foreseen for high quality sparkling wine market. However, the hitherto technologic development within the industry has not been able to provide sufficient advance needed to efficiently respond to the growing everyday demand. Today, European and global producers struggle with rigid processing technologies that are time consuming and costly to implement and maintain. The key limiting factor is the current processing technology for separation of yeast sediment from the bottles, which represents the mandatory last step before the product can be shipped to the market. Currently available solutions to perform the separation process require a complex, several weeks long procedure, which can only be performed using the expensive and outdated separation equipment, developed in the 1970s. As a result, producers on average loose approximately 30% of their annual demand, accompanied with high storage requirements and high operational costs. The objective of the project is to evaluate feasibility for MagYeast, prototyped and patented modern processing solution, that allows rapid separation of the yeast from the sparkling wine bottle in as much as 30 minutes. MagYeast represents the first solution for flexible and cost-efficient production of high quality sparkling wines, which enables the producers to ship their products within the same day as ordered. With MagYeast, producers benefit from: a) increased sales, b) reduced operational costs, c) reduced storage requirements and d) significantly improved overall profitability.

Keywords: cost efficient,wine processing technologies,advanced material synthesis,high quality sparkling wine,magnetic separation of yeast,eco friendly technology
Dynamic Penetrating Peptide Adaptamers (DYNAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-02-01
End date: 2022-07-31
Duration (months): 78.0
Total project cost (EUR): 1492525.0
EU funding (EUR): 1492525.0
Participants: 1
Project status: CLOSED

The aim of this proposal is to identify, at the molecular level, the minimal topological and structural motifs that govern the membrane translocation of short peptides. A covalent reversible bond strategy will be developed for the synthesis of self-adaptive penetrating peptides (adaptamers) for targeted delivery. It is known that the recently developed therapeutic technologies (i.e. gene therapy, chemotherapy, hyperthermia, etc.) cannot reach their expected potential due to limitations in the current delivery strategies, which hinder the efficient targeting of the appropriate tissues, cells and organelles. Despite the enormous therapeutic potential of short penetrating peptides, these molecules suffer from drawbacks such as toxicity, instability to protease digestion and lack of specificity. Dynamic covalent chemistry has significant synthetic advantages. In the proposed research, peptide scaffolds with clickable reversible groups (e.g. hydrazide) will be conjugated with collections of aldehydes to afford self-adaptive biomimetic transporters, whose secondary structure and penetrating properties will be systematically characterized by biophysical, cell-biology and pattern recognition techniques. The versatility of dynamic supramolecular “peptide adaptamers” with precisely positioned protein ligands will be explored for multivalent specific recognition, protein transport, cell targeting of drugs and probes and membrane epitoping. Additionally, we propose to synthesise dynamic and environmentally sensitive fluorescent probes for biocompatible membrane labelling and uptake signalling. The resulting discoveries of this research will allow the formulation of novel transfecting reagents for gene therapy, selective platforms for drug-delivery and the development of dynamic fluorescent membrane probes. The potential results of this proposal will shake the fields of drug-delivery and non-viral gene transfection and will resolve the limitations of the current approaches.

Keywords: peptide chemistry,lipid membranes,synthetic transporters
Cleave and couple: Fully sustainable catalytic conversion of renewable resources to amines (CatASus)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria,Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2023-04-30
Duration (months): 84.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 62500.0
Participants: 2
Project status: SIGNED

Amines are crucially important classes of chemicals, widely present in pharmaceuticals, agrochemicals and surfactants. Yet, surprisingly, a systematic approach to obtaining this essential class of compounds from renewables has not been realized to date. The aim of this proposal is to enable chemical pathways for the production of amines through alcohols from renewable resources, preferably lignocellulose waste. Two key scientific challenges will be addressed: The development of efficient cleavage reactions of complex renewable resources by novel heterogeneous catalysts; and finding new homogeneous catalyst based on earth-abundant metals for the atom-economic coupling of the derived alcohol building blocks directly with ammonia as well as possible further functionalization reactions. The program is divided into 3 interrelated but not mutually dependent work packages, each research addressing a key challenge in their respective fields, these are: WP1: Lignin conversion to aromatics; WP2: Cellulose-derived platform chemicals to aromatic and aliphatic diols and solvents. WP3: New iron-based homogeneous catalysts for the direct, atom-economic C-O to C-N transformations. The approach taken will embrace the inherent complexity present in the renewable feedstock. A unique balance between cleavage and coupling pathways will allow to access chemical diversity in products that is necessary to achieve economic competitiveness with current fossil fuel-based pathways and will permit rapid conversion to higher value products such as functionalized amines that can enter the chemical supply chain at a much later stage than bulk chemicals derived from petroleum. The proposed high risk-high gain research will push the frontiers of sustainable and green chemistry and reach well beyond state of the art in this area. This universal, flexible and iterative approach is anticipated to give rise to a variety of similar systems targeting diverse product outcomes starting from renewables.