Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigating the Roles and Mechanisms of Action of Estrogens via Estrogen Receptor ß in Granulosa Cell Tumours of the Ovary (ESTROVARYTUMOUR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-03-01
End date: 2015-06-21
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Granulosa cell tumours (GCT) are a rare form of malignancy affecting women of all ages. Because GCT display a high propensity to recurrence and there is no efficient curative treatment beyond surgery, ~ 20% of adult patients die of the consequences of their tumour. However, despite the importance and insidiousness of GCT, very little is known of its molecular etiology. Although most GCT produce estrogens and strongly express estrogen receptor ß (ERß), the role of estrogens in GCT pathogenesis is currently unknown. Given the stimulatory effect of estrogens via ERß in the normal ovary on granulosa cell proliferation and survival, one can hypothesize that estrogens would exert similar actions in tumoral granulosa cells, thereby favouring GCT growth. Besides, estrogens stimulate cell metastasis in other cancers. The possibility that estrogens would exert a stimulatory role on GCT growth and metastasis is further suggested by my recent findings showing that, in tumoral granulosa cells, estrogens activate the phosphatidyl-inositol 3 kinase (PI3K) pathway by non-genomic actions. The PI3K pathway is frequently overactivated in human cancers to contribute to cell proliferation, survival and metastasis. This proposal, therefore, aims at 1) investigating the possibility that estrogens stimulate GCT growth and metastasis via ERß, and at 2) further understanding their underlying mechanisms of action, with a special emphasis on estrogens non-genomic mechanisms leading to the activation of the PI3K pathway. To address these goals, I will take advantage of the availability in the host laboratory of tumoral granulosa cell lines established from human GCT to carry out in vitro studies and to perform in vivo analyses with a xenograft mouse model. Overall, this proposal will provide important insights into the role of estrogens in GCT growth and progression and their molecular mechanisms with a special emphasis on novel modes of estrogens action through non-genomic mechanisms.

Keywords: ovarian cancer,estrogens,er?,non genomic action,mouse model,pi3k,preclinical study
The inverse-resistance relationship between platinum and taxane chemotherapy (CISTAX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-03-01
End date: 2014-02-28
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The chemotherapeutic drugs cisplatin and paclitaxel are used in the treatment of ovarian cancer. However, the rate of relapse after therapy is high and is often due to the development of drug resistance. Drug-resistant cancer cell lines in the laboratory frequently have an inverse resistance relationship between cisplatin and paclitaxel. When cisplatin resistance occurs, cells are likely to have no change in resistance to paclitaxel and some cells even become more sensitive to paclitaxel. There is also clinical evidence to support the benefit of alternating between cisplatin and paclitaxel therapy in ovarian cancer. The aim of this project is to understand the molecular mechanism of inverse-resistance by identifying genes and proteins associated with the resistance phenotype in a panel of drug-resistant cancer cell lines. One gene which we have associated with the mechanism of inverse-resistance by literature search is BRCA1. This project has three phases 1) Genomic and proteomic profiling of a panel of drug-resistant cell lines; 2) Functional validation of identified targets and understanding of the mechanism of inverse resistance and 3) Investigation of the role of BRCA1 in the inverse-resistance relationship between cisplatin and paclitaxel. Validated molecular markers associated with the inverse-resistance relationship could potentially be used as a clinical test to determine if an individual patient is likely to be resistant to cisplatin or paclitaxel therapy. Patients likely to respond to cisplatin or paclitaxel could be given the appropriate drug, while patients unlikely to respond to either can be given alternative chemotherapy.

Keywords: oncology,anticancer therapy,cell biology,molecular markers and recognition,proteomics
Processing of 3D Digital Cities (P3DC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-07-01
End date: 2015-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Increasing interest in modeling and reconstruction of digital urban scenes may largely be attributed to recent advances in scanning technology and the proliferation of GIS services such as those offered by Microsoft Virtual Earth or Google Earth. We are thus witnessing a strong trend towards reconstruction and visualization of urban scenes based on satellite photography combined with street-level and aerial laser scanners. Nevertheless, scanned point clouds are typically of low quality and exhibit significant missing data (due to occlusion), as well as uneven point density, noise and outliers. In this project I plan to research techniques for efficient denoising, reconstruction and visualization of 3D urban scenes. This is a pioneering effort towards the goal of generating 3D digital cities from LiDAR scanned data. My first objective is developing an interactive tool for reconstruction of complex structures and fine details from scanned urban scenes. The interaction paradigm borrows from a sheet layout metaphor where a thin elastic sheet that is laid over some 3D terrain deforms and captures the terrain's structure. This will be achieved through a set of interaction operations, allowing computation of mesh surfaces that will accurately reconstruct complex urban buildings. In my second objective, I plan to explore and fuse two modalities: 2D photographs and 3D scans of urban buildings. After accurately registering these two modalities using feature correspondence, I plan to use domain specific knowledge to improve and enhance the data mutually. My third objective is visualization and navigation of 3D digital cities. State-of-the-art navigation systems such as Google Street View and Microsoft Streetside enable users to visit cities virtually by navigating static 2D photos. My goal is to explore ways of navigation through complex 3D environments and their integration with 2D maps by optimizing a set of terms such as speed, view direction, etc.

Keywords: computer graphics,interactive techniques,shape reconstruction,urban modeling
MicroElectroMechanical Generators Based on High Performance Piezoelectric Materials (MICROGENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Romania
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-07-01
End date: 2014-06-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The process of acquiring small amounts of ambient thermal, mechanical or electromagnetic energy surrounding a system and converting it into usable electrical energy is called power energy harvesting. At international and European level there is an actual interest towards a large panel of applications, from the off-grid rural regions of emerging markets (mobile charging solutions, lighting) to the modern building industry (wireless sensor networks and switches) or transportation (wireless safety monitoring in automotive and railroad). The overall objective of the proposal is advancing the research frontier towards more integrated and more autonomous piezoelectric energy harvesters by using innovative piezoelectric materials for converting the commonly unused mechanical energy that is dissipated into vibrations and shocks of various structures. This captured electrical energy could then be used for extending the power supplies life or, in the ideal case, may provide a complete and permanent supply energy. The research activities into innovative PMN-PT piezoelectric materials of the former Intra European Fellowship are continued towards integrated micro-electro-mechanical devices (PiezoMEMS) able to convert low levels of ambient vibrations and impulses. Optimised circuits intended for the storage of energy into supercapacitors or miniature batteries will be designed. Finally, suitable applications in the fields of sensors, actuators and wireless distributed systems will be identified and implemented. The proposal realises a collaboration between the former Intra European Fellowship host (FEMTO-ST, France) and the re-integration institution (UVT, Romania) in agreement with the call specificities and given the proven expertise in renewable energy sources (re-integration host) and in micromechatronics and piezoelectric devices (former fellowship host).

Keywords: technological sciences,renewable sources,energy harvesting,piezoelectricity,microtechnology,micromechatronics,control systems,embedded control,electronics,piezo-mems
Roles of Hydrogen Sulfide and its Metabolites in Neutrophil Function and Redox Signaling (NHS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-06-01
End date: 2015-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Inflammation is a fundamental pathological event, which is described as a protective response to abnormal stimulus. However it is also responsible for a plethora of inflammatory diseases. A major role of hydrogen sulfide is suggested in inflammation, but published results are controversial. In large quantities it is toxic, but it is also produced inside the body during the metabolism of the amino acid cysteine. I propose to provide insight into the molecular mechanisms of how hydrogen sulfide mediates inflammatory events via studying the biochemistry of its interactions with neutrophil white blood cells that are major players in inflammation. We will study its reactions with neutrophil derived oxidants and free radicals. I propose that hydrogen sulfide will either detoxify them or the reactions will generate bioactive products. We will investigate the reactions of hydrogen sulfide and its metabolites with the antimicrobial neutrophil enzyme, myeloperoxidase. We will study the effects of these reactions and products on neutrophil function. In addition, oxidation and reduction of cysteine residues is an important mechanism of regulating protein function and cell signaling and hydrogen sulfide should readily integrate into these pathways. We will study the redox chemistry of hydrogen sulfide with cysteine derivatives. We will elucidate the kinetics and mechanisms and characterize the products of these reactions. I propose that our study will provide insight into the potential of these reactions in hydrogen sulfide trafficking and regulating in vivo redox homeostasis. The obtained results should significantly advance our understanding how drugs targeting hydrogen sulfide may be effective. The therapeutic potential of hydrogen sulfide represents a multibillion euro business with many clinical trials in progress. The results of this study will be essential for assessing its toxic versus beneficial health effects as a potential anti-inflammatory drug.

Keywords: reaction mechanisms and dynamics,enzimology,redox biochemistry,hydrogen sulfide,neutrophil function,thiol oxidation,myeloperoxidase,oxidative stress,free radicals
Search for novel molecules cross-talking between muscle and cancer with therapeutic potential against cachexia and cancer (MUSCLEANDCANCER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2012-06-01
End date: 2016-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Cancer cachexia is a life-threatening syndrome characterized by severe body weight loss, due to depletion of adipose tissue and skeletal muscle, and affects up to 80% of patients with advanced cancers. The rapid loss of muscle mass is the main cause of function impairment, fatigue and respiratory complications, leading to death in 20-48% of cases. To date, no effective treatment is available. By using Ingenuity Pathways Analysis software, I have analyzed the cancer cachexia-specific genes, found previously by others, and discovered a specific signaling pathway altered in muscles of cachectic rats. By over-expressing and repressing genes of this pathway in in vitro (adenoviral infection of myotubes) and in vivo (muscle electroporation of plasmids in mice) approaches, I will dissect the role of this signaling cascade during cachexia. Since agonists and antagonists for this pathway are already available, they will be also tested for their possible protective effects against cancer cachexia. Physical activity extends life span of cancer patients and correlates with lower incidence of many cancers but its modes of action are still unclear. The concept that muscle is an endocrine organ able to release molecules (myokines) is quiet new and opens exciting fields to explore. Interestingly, the unique resistance of muscle to cancer and metastasis makes reasonable that anti-cancer myokines may exist. Their secretion especially during physical activity could explain why exercise protects from cancers and retards its progression. So, I propose to search for novel anti-cancer molecules from exercised muscles by taking advantage of adenoviral infection of myotubes to express molecules able to mimic some of the effects of (strength or endurance) exercise. The isolation of anti-cancer myokines may greatly help cancer patients, especially those that cannot exercise, and may clarify which type of exercise (i.e. strength and/or endurance) could be more beneficial for cancer patients.

Keywords: muscle,cancer cachexia,specific cachectic signaling,anticancer therapy,exercise-induced myokines.
Behavioural Spillovers and the Design of Institutions and Markets (BSDIM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2012-02-01
End date: 2015-01-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Behavioural Spillovers are observed across many markets and institutions. The equity premium puzzle in financial markets can be thought of as resulting from behavioural spillovers, but there are many other examples. With the IEF we have tried to understand how such spillovers can arise. With the reintegration grant we aim to show how this understanding of spillovers can be used for the design of markets and institutions. In the first year of the IEF (PIEF-2009-235973) we have successfully developed a theoretical framework to understand how behavioural spillovers can arise. The research articles resulting from this part of the project have been submitted to international Journals and we have already been requested to revise several of them for publication. The current proposal aims at taking this project a step further in order to study how such behavioural spillovers can be made use of for a more efficient design of institutions and markets. The proposal consists of three main objectives, which we will describe in the following. Part 1) consists in developing a theoretical framework to understand how behavioural spillovers can be exploited for institution and market design. Part 2) aims at understanding behavioural spillovers in specific markets and institutions, where in particular we will study (a) risk-taking behaviour in financial markets and (b) the provision of public goods. Part 1) and Part 2) are not clearly separated in time and can be worked on simultaneously. Part 3) integrates the two previous steps to show how (a) financial markets as well as (b) mechanisms for the provision of public goods can be improved to account for the behavioural spillovers identified. The project will be executed at Maastricht University in close collaboration with an international group of researchers mainly from the department of Economics, but also with some psychologists.

Keywords: microeconomics,game theory,experimental economics
SULFIDE AND GREENHOUSE GAS EMISIONS FROM MEDITERRANEAN SEWERS (SGHGEMS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-03-01
End date: 2015-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Production and build-up of sulfide and methane in wastewater collections systems causes several detrimental effects. Sulfide accumulation in sewers causes: i) odour nuisance in sewer surrounding areas, ii) health hazards due to its toxicity, and iii) corrosion of pipes and inlet structures of sewage treatment plants. On the other hand methane is a greenhouse gas with significantly contributing to global warming. Despite these significant impacts, sewer-produced sulfide and methane are yet to be considered in the management of Mediterranean Urban Water Systems. Additionally, detrimental emissions are expected to increase in the Mediterranean region due to predicted climate change and water scarcity scenarios. The current research project aims to study and mitigate the production of sulfide and greenhouse gas emissions from sewers exposed to Mediterranean climate conditions. The project methodology combines extensive experimental work on real sewers with advanced mathematical modelling to provide effective applicable control measures. The objective is to carry out the first quantification of sulfide and methane from Mediterranean sewers and also to create advanced management tools that include control of sewer emissions for optimal operation of urban water systems.

Keywords: sewers,sulfide,methane,greenhouse gas emissions,mediterranean basin,mitigation strategies,optimal management,mathematical modelling,environmental engineering,urban water systems
The real impact of healthier products on consumption and calorie intake. (HEALTHY PRODUCTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-06-01
End date: 2014-05-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Several Western governments have declared obesity as one of today’s most urgent challenges. One of the remedies suggested to solve the obesity problem has been the development and stimulation of healthier products. Not surprisingly, companies have realized the opportunities, and healthier product versions have become big business. Apart from the low-fat varieties that are now present in almost every product category, also other functional health claims (e.g. extra vitamins) are frequently used. Common wisdom would suggest that the consumption of healthier product versions would indeed increase a consumer’s health. However, recent experimental research has shown that the effect of these healthier products may not be as straightforward as originally thought, to the extent that it may even lead to increased consumption and even calorie intake in certain circumstances. I propose to study health claims in a real-life setting, and examine their effect on actual category consumption quantity and calorie intake both in the short and long term. I use a unique dataset consisting of real purchase data in many product categories for a large household panel, combined with product information such as the type of health claims used and the nutritional information. The large amount of cases will not only allow to generate generalizable knowledge on the effect of health claims on real consumption behavior, it will also allow to study the potential moderating impact of the type of health claim (low-fat versus functional), as well as consumer and category characteristics.

Keywords: health claims,food consumption,calorie intake,real-life data