Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding diversity in decision strategy: from neural circuits to behavior (DIVERSE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1996415.0
EU funding (EUR): 1996415.0
Participants: 1
Project status: SIGNED

The brain has the remarkable ability to imagine diverse solutions to complex problems and to rapidly switch between them to adapt to new situations. Such properties are essential for adaptive behavior but remain poorly understood, partly due to the prevalent focus in previous studies on stereotypical behaviors. Here, we will adopt a fundamentally different approach by exploring the neural properties underlying diversity in decision strategy, aiming to provide greater insights into how the brain operates in natural conditions. By leveraging novel computational methods that identify changes in behavioral strategy combined with the latest advances in electrophysiological recording and optical manipulation in mice, the overarching goal of the project is to understand how the brain switches between different decision strategies. We hypothesize that the brain achieves remarkable flexibility by running multiple decision processes in parallel, allowing animals to select one decision strategy while their brains maintain several alternative solutions readily available for quick adaptation. We will test this hypothesis through a series of experiments that aim at determining: (1) Which neural circuits are involved in strategy selection? (2) What neural mechanisms control changes in strategy? (3) How to trigger a strategy in neural circuits and behaviors? We will address these questions using mice in the context of foraging, a fundamental survival behavior shared among all animals, involving the search for resources in dynamic environments. The project will deliver a rich and unique neural and behavioral dataset, enabling the development of a novel conceptual framework for behavioral flexibility as an adaptive selection mechanism of parallel decision computations. Ultimately, this research will contribute to solving various aspects of the decision-making puzzle and provide a foundation for explaining the diversity in behaviors, including those that deviate from the norm.

Keywords: premotor cortex ensemble recording mouse foraging neural circuits electrophysiology calcium imaging population dynamics
Roman Making and its Meanings: Representations of Manual Creation in the Literature and Art of Imperial Rome (FACERE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 1499999.0
Participants: 1
Project status: SIGNED

How did the ancient Romans respond to the material world around them? This project, FACERE, proposes a new way of approaching this question. It studies ‘making’ – the processes by which the objects and buildings which surrounded Romans in their daily lives were produced. How things were made in ancient Rome is usually studied as a practical or technical process. However, making also has a wide range of culturally specific aesthetic and moral implications. FACERE breaks new ground by asking not how making was done, but what making meant to the inhabitants of the Roman empire. To answer this question, we analyse the Roman discourse of making: literary texts – poetry and prose in Greek and Latin – and visual art works, such as paintings, reliefs, and mosaics, which represent processes of making and can tell us how Romans thought, felt, and spoke about them. FACERE aims to achieve two key objectives. First, we will write a new cultural history of ‘Roman making’, adding to our understanding of the technological, logistic, and economic dimensions the crucial new dimension of the cultural values involved in making, in particular its aesthetic and moral complexities. How did making relate to Roman notions about the environment? How did Roman writers and artists depict the ability and agency of different kinds of makers, and how does this relate to their gender, ethnicity, and social status? Were certain ways of making considered superior to others, and why? Second, FACERE proposes a new way of investigating the impact of material culture on Roman viewers. How things were made, and how their stories of making were presented or imagined, was deeply relevant to what they meant to their ancient viewers, owners, and users. FACERE introduces the innovative analytical concept of ‘madeness’, which allows us to bring ‘making’ and ‘meaning’ together.

Keywords: making,discourse,representation,text,roman literature,roman art,material culture,ecocriticism,intermediality,cultural history
SNS COLLABORATIVE OPERATIONS AND OUTPUT OPTIMISATION (SNS CO-OP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Coordination and support actions
Partnership: SNS (JU-JTI)
Countries involved: Germany,Belgium,Sweden,Norway,Italy,France,Ireland,Estonia,Portugal,Netherlands,Spain,Latvia,Finland,Poland
Call: SNS Operations and Output optimisation (HORIZON-JU-SNS-2024, 2024)
Start date: 2025-01-01
End date: 2027-03-31
Duration (months): 27.0
Total project cost (EUR): 4173385.0
EU funding (EUR): 3910279.0
Participants: 23
Project status: SIGNED

The SNS CO-OP project is devoted to supporting and facilitating the activities of the SNS Initiative under the Smart Networks and Services Joint Undertaking (SNS JU). The SNS CO-OP project will achieve this by orchestrating and organising strategic activities, in collaboration with the SNS JU Office and the 6G Industry Association, to capture and promote the European Industry view on 6G, the achievements of the 6G SNS initiative and projects, and to promote the ambitions of the SNS JU. The SNS CO-OP project will build on the strengths and assets of the platforms and communities, established through the SNS OPS and SNS ICE work, to stimulate and align complementary activities across the wider community of 6G SNS stakeholders. SNS Co-Op will also ensure the long term continuity of the SNS facilities for subsequent phases of the SNS JU. In addition, the SNS CO-OP project will provide the support for the EUCNC & 6G Summit events in 2025 and 2026 building on the 6GStart achievements and experience. The SNS CO-OP project will provide an experienced competent project team that builds on the recent experiences of the SNS OPS and SNS ICE projects team to guarantee a seamless handover of all SNS support activities for maximum efficiently and value. The SNS CO-OP project proposes a comprehensive workplan that, from the experience of the participants, will deliver the expected outcomes and impacts as specified in the work programme. Particular care was taken to dimension the tasks appropriately for the likely scale and significance of the contributions from the projects. The SNS CO-OP team will use measurable parameters to regularly assess the dissemination and communication effectiveness which will facilitate monitoring and improving the suitability and quality of the project work with a view to maximising the expected impact of the SNS Initiative in partnership with all running SNS projects.

Keywords: smart networks and services,joint undertaking,6g,sns initiative
Supporting and Developing WIdening Strategies to tackle Hydroclimatic Extreme Events: impacts and Sustainable solutions for cultural heritage (SD-WISHEES)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Italy,Kenya,Belgium,Georgia,Malta,Romania,Netherlands,France,Portugal,Spain,Albania,United Kingdom
Call: Support for policy makers – Programme level collaboration between national R&I programmes (HORIZON-WIDERA-2022-ERA-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2728912.5
EU funding (EUR): 2728912.5
Participants: 16
Project status: SIGNED

The purpose of the proposal put together by the Climate JPI and the Water JPI is to “enable collaboration between national research and innovation funding members to address together the protection of cultural heritage in Europe and beyond. With this purpose, both JPIs will support the implementation of multi-annual joint activities that will focus on the better understanding of, and the identification of best available adaptation solutions in response to hydroclimatic extreme events”. The Consortium established by both JPIs gathers today 16 organisations including programme owners (funding agencies from Belgium, France, Georgia, Italy, Malta, UK, Kenya, Portugal and Romania), research performing organisations/ academia, foundations and private companies. The following operational objectives have been laid out by the Consortium: - Enhance cross-sector collaborations and strategic coordination between water, climate and cultural heritage. - Launch and monitor joint activities to measure progress towards widening. - Address potential barriers for collaboration. - Evaluate the impacts of those joint activities on widening policies as well as EU and international policy frameworks, notably the EU Green Deal and the Sustainable Development Goals (SDGs). - Implement joint activities enabling the market, regulatory and societal uptake of results. The project will be structured around 6 work packages (WP) looking at the coordination of activities (WP1), the identification of relevant gaps in the fields of cultural heritage, water and climate (WP2), the launch of joint activities, the TAP instrument (Thematic Annual Programming; WP3), communication and dissemination of project results (WP4), the analysis of impacts of proposed actions on EU widening strategies (WP5), and the implementation of specific tools to enable the social, regulatory and market uptake of proposed innovations stemming from joint activities (WP6).
Identification of novel therapeutic approaches to target the immune checkpoint protein B7H3 (UBImmune)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Immunotherapies have revolutionized the treatment of multiple cancer types in the last decade. Nonetheless, non-small cell lung cancer and triple-negative breast cancer exhibit only restricted response to immune checkpoint blockade. Especially in advanced tumor stages, clinical options are limited and novel approaches to enhance anti-tumor immune responses are needed. The immune checkpoint family member B7H3 (PD-L3) is frequently upregulated in cancer cells. Studies have shown that B7H3 promotes tumor growth in a cancer-cell autonomous fashion and inhibits immune cells in the tumor microenvironment. Despite being an important clinical target, its posttranslational regulation and functional interactors on T cells are poorly understood. The proposed project aims to identify novel approaches to target B7H3 by harnessing the ubiquitin system and to identify B7H3’s interactors on human T cells with the objective of enhancing clinical treatment options for cancer patients. My experience in solid tumor biology and anti-tumor immunity, paired with the host lab's expertise in studying the ubiquitination system, will be a great catalyst for the proposed project enhancing its likelihood of success. This fellowship will allow me to conduct cutting-edge research at the Center for Translational Cancer Research of the University Clinics rechts der Isar of the Technical University of Munich (TUM), a renowned research institution with a well-recognized supervisor Prof. Bassermann, allowing me to expand my international network, scientific skills as well as leadership and management skills. Ultimately, this fellowship will be a tremendous stepping stone in my scientific career. It will bring me closer to my goal of becoming an independent researcher working at the interface of cancer biology, protein biochemistry, and cancer immunology, where I can put my own projects into practice, and train the next generation of international scientists.

Keywords: cancer immunology,ubiquitin,crispr screens
Inborn errors of translation reinitiation in humans with Mendelian susceptibility to mycobacterial disease (REI_MSMD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Mendelian susceptibility to mycobacterial disease (MSMD) is characterized by severe infections with weakly virulent mycobacteria in otherwise healthy patients. All known 31 genetic etiologies are inborn errors of interferon gamma (IFN-g) immunity and collectively account for about half of the cases. We discovered private, hemizygous, predicted loss- of-function (pLOF) mutations in the X-linked ribosome recycling and reinitiation factor MCTS1 gene in five unrelated MSMD male patients. The connection with MSMD is surprising, because the MCTS1 protein is typically thought to be involved in housekeeping of translation machinery and translational control of gene expression. Although the genetic evidence alone is compelling, we propose to further prove causality by discovering the molecular and cellular mechanism by which MCTS1 deficiency underlies MSMD. This project will hence help to better understand the previously unappreciated connection between regulation of translation reinitiation and IFN-g immunity. The Casanova Group has worked on MSMD for more than 25 years and identified most inborn errors of IFN-g immunity. I have spent my PhD working on the basic molecular mechanism of MCTS1. I am therefore a highly suitable candidate to join the Casanova group and to work on this project.

Keywords: mcts1,denr,reinitiation,translation,msmd,mycobacterial disease,interferon,immunity,infection,genetics
QSM in plaque vulnerability diagnosis – a software tool for early clinical assessment (VASCOLL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Stroke is the leading cause of disability and the third leading cause of death in the Western World. Over 50% of strokes occur in asymptomatic patients and therefore better indicators of the disease are required. These acute asymptomatic cerebrovascular events are due to vulnerable plaque rupture leading to thromboembolic events, stroke, and/or sudden death. From our work to-date as part of ERC Starting grant FibreRemodel, we have found that that most significant contributor to rupture strength of a plaque is the underlying collagen fibres within this tissue, particularly within the fibrous plaque cap. The underlying structure of the carotid plaque may therefore be used to determine the risk of vulnerable plaque rupture. However, a non-invasive diagnostic technique, which uses knowledge of in vivo arterial collagen content, has yet to be developed. VASCOLL will generate the first software tool that can inform on plaque vulnerability in a non-invasive way, enabling early diagnosis of the predisposition of a carotid plaque to rupture and facilitating the selection of the optimum treatment minimising the need for surgery and healthcare-associated costs. This approach will offer a number of significant benefits over current approaches to vulnerable plaque identification. Firstly, this technique will be the first ex vivo and in vivo application of the QSM technique to human arteries and carotid plaques to exploit the sensitivity of magnetic susceptibility to collagen content in arteries. Secondly, this technique is relatively easy and efficient to translate in vivo. Given that this method determines the underlying plaque and vessel structure, not merely level of stenosis, VASCOLL will transform how vulnerable carotid plaques are identified and treated.
CLIMate policy integration – a comPLEXITY trap? (Climplexity)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Public policy research finds integrating climate change into other policy sectors a key to achieving climate goals. The EU has set climate as a horizontal priority and adopted a multitude of policies across sectors. Yet, the EU is projected to miss its net-zero goal for 2050. Why? I propose an explanation. As climate-related policies proliferate, they do not necessarily add up coherently and pave the way for a complexity trap. However, we do not have a system-level picture of synergistic and contradictory climate-relevant interdependencies between EU policies. Such knowledge would be needed to unpack implementation barriers that hinder success in climate policy. The issue is under-investigated because we lack adequate theories and study methods. CLIMPLEXITY’s goal is to develop a new theory about policy integration processes to explain why growing policy regimes remain poorly coordinated given actors’ constellations of power and cross-sectoral activities. To quantitatively model policy interdependencies, CLIMPLEXITY proposes a network method linking synergistic or contradictory policy instruments and goals. Results will reveal patterns of policy (dis)integration, their temporal dynamics and system-level solutions via simulated policy reforms. Do political actors then overcome the policy complexity trap or rather add to it? For the EU and selected members states, CLIMPLEXITY compares the coordination mechanisms political actors use to integrate overarching issues like climate across sectors. Based on my expertise in analysing actor constellations in policy processes, I combine rich qualitative and quantitative methods, including process tracing, interviews, surveys, comparative case studies and advanced network analysis. CLIMPLEXITY will deliver insights and advice to improve climate policy integration in the EU. Given the widely observed phenomenon of policy disintegration, the project’s contribution to advance the debate will reach far beyond climate policy.

Keywords: public policy,policy processes,policy dis integration,climate policy integration,environmental policy integration,climate policy,policy instruments,social network analysis
Rehabilitation and Diagnosis of Hearing Loss based on Electric Acoustic Interaction (READIHEAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1978875.0
EU funding (EUR): 1978875.0
Participants: 1
Project status: SIGNED

Hearing loss is the most common sensory deficit in the elderly, and it is becoming a severe social as well as a health problem. Across the whole lifespan, from new-borns to the elderly, hearing loss impairs the exchange of information, thus significantly impacting everyday life, causing loneliness, isolation, dependence, frustration and communication disorders. Cochlear implants (CIs) are hearing prosthetics that stimulate the auditory nerve with electrodes placed inside the cochlea. CIs are gradually being implanted in subjects retaining low-frequency residual hearing. In general, these subjects obtain large benefits in speech perception from electric acoustic stimulation, although large variability exists and some subjects do not benefit. Therefore, it is highly desirable to create objective diagnostics to assess acoustic low-frequency hearing to indicate cochlear implantation, to monitor and preserve hearing during the implantation procedure and to understand the mechanisms related to electric acoustic stimulation benefits. The ground-breaking nature of the READIHEAR project is to investigate the fundamental interaction mechanisms between electric and acoustic stimulation across the auditory pathway, from the cochlea up to the auditory cortex. The fundamental understanding will set the basis for a new generation of diagnostic devices of hearing loss that combine for the first time minimally invasive electric acoustic stimulation. Moreover, READIHEAR will assay a novel auditory prosthetic that makes use of the interaction mechanisms between acoustic and electric stimulation delivered through minimally invasive electrodes. These developments will be beneficial for a large population suffering from hearing loss across the whole lifespan, from young children who will benefit from improved hearing diagnostics to the elderly population who will benefit from minimally invasive electric acoustic stimulation technology as the treatment for age-related hearing loss.