Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of epithelial sodium channels in adult neural stem cells. (ENAC_IN_ANSCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-06-01
End date: 2016-05-31
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

During adulthood, new neurons are generated by so called adult neurogenesis in the subgranular zone (SGZ) of the hippocampus and in the subventricular zone (SVZ) of the lateral ventricles. In these neurogenic niches, the adult neural stem cells (aNSCs) generate new neurons that are critical for establishing factual memories and mood control. Regulation of aNSCs is critical for cognitive brain functions and for development of future cell-based therapies of neurodegenerative diseases. While genetic and paracrine regulation of aNSCs have been studied extensively, the nature of molecular sensors detecting changes in their microenvironment is unknown. Pilot genome and functional analyses presented in this proposal show that the epithelial sodium channel (ENaC) may serve as a candidate for such sensor in aNSCs. ENaC is found to be enriched in aNSCs over other sorted cell types from the brain and blocking ENaC impairs aNSCs. This proposal combines electrophysiology, live-cell imaging, genome screening and transgenic mouse technology to address two fundamental questions. First, can ENaC act as molecular sensors for aNSCs detecting environmental changes in the niche? Second, how are SVZ and hippocampal aNSCs differentially regulated by ENaC? The proposed experiments embody the call for the transfer of knowledge and the need for competitiveness on both intellectual and technical levels. The host laboratory belongs to world leaders in SVZ neurogenesis and has demonstrated technical prowess by developing new techniques such as the cell-clone analysis by long-term live imaging. The proposing researcher is an expert in SGZ neurogenesis and brings his electrophysiological expertise from the USA to the European host lab. This proposal thus aims to open new research venues for the field of adult neurogenesis by combining technical and innovative capacities of the host lab with the unique skill set and expertise of the proposing researcher.

Keywords: adult neural stem cells,epithelial sodium channel,adult neurogenesis,svz,sgz,hippocampus,electrophysiology
Development of Next Generation Cobalt Superalloys - Understanding and Limiting Microstructure Degradation and Creep (CO-SUPERALLOYS APT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-06-04
End date: 2017-06-03
Duration (months): 36.0
Total project cost (EUR): 282109.2
EU funding (EUR): 282109.2
Participants: 1
Project status: CLOSED

Ni superalloys utilised in gas turbine hot sections are mature, and their temperature capability is the limitation to improving engine efficiency and reducing CO2 emissions. The Co superalloys demonstrate higher temperature capabilities and are a potential replacement. Successful alloy development will boost the EU economy by increasing the competitiveness of Rolls-Royce (UK’s largest exporter), and invigorate multi-disciplinary research across the ERA. Other gas-turbine technologies will require research and development due to higher operating temperatures, such as ceramic coatings and mechanical design of turbomachinery. Superalloys are strengthened by fine coherent ordered γ′ particles that hinder dislocation motion through the γ matrix. The γ/γ′ interface has an associated interface width, and the importance of this width in governing microstructural evolution (coarsening) and associated loss in creep strength is debated. It has recently been shown that the interface width can be controlled with alloying additions. In this proposal, interface widths will be systematically altered across a range of Co-Ni-Al-W-Cr superalloys, measured by atom-probe tomography, and coarsening experiments performed to determine if this width is the rate-controlling mechanism during coarsening. Interpretation will be aided by development of a coarsening model. Coarsening will be related to mechanical properties by performing creep tests on samples with different microstructures, and an extensive TEM study is proposed. The supervisors, Prof. Seidman, Prof. Voorhees, and Dr. Stone, are world leaders in their respective fields at world leading Universities, Northwestern University and Cambridge University. The application discusses the development of the researcher to ensure his future success on his return to the ERA and a strong outreach proposal that will publicise the Marie Curie program to the general public and develop scientific interest for pre-university students.

Keywords: cobalt-base superalloys,atom probe tomography (apt),coarsening,coarsening mechanism,microstructure,interfaces,microstructural evolution,creep,heat-treatment,dislocation micromechanisms
Immanence and Social Normativity. Spinoza and the invention of sociology in France and Germany 1871-1918 (IMMA-NORM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-09-01
End date: 2017-08-31
Duration (months): 36.0
Total project cost (EUR): 360578.3
EU funding (EUR): 360578.3
Participants: 1
Project status: CLOSED

My proposal focuses on the uses of Spinoza’s thought in French and German sociological literature from the last three decades of the 19th century up to the end of the First World War. It was in these countries and this period that sociology was progressively institutionalized as an academic discipline. Sociology’s claim for institutional and epistemological autonomy provoked an inevitably tension with political philosophy. The quest for a different conception of normativity was at the core of this querelle. In opposition to the classical conception of political normativity, sociologists posited that moral and legal norms were not imposed by legislators or established by philosophers, but should be analysed as the historical effects of the society’s power to self create. Spinoza was a crucial reference for the early sociologists Tönnies and Worms, Simmel and Tarde and their endeavor to provide a theoretical foundation for the new discipline. Interestingly, however, this reference progressively disappears from the sociological debate from the 1890s onwards, and Spinozism was replaced by normative and Neo-Kantian approaches, as, partially, in Durkheim or definitely in Weber. In this project I intend to provide the first rigorous historical investigation of Spinoza’s uses in classical sociology, thus offering a new paradigm for the philosophy of social sciences. My project aims to answering two sets of questions: 1. Why were classical sociologists drawing on Spinoza? What theoretical devices did Spinozism provide and how did these conceptual tools match the theoretical and epistemological expectations of classical sociology? 2. How are we to interpret the fact that Spinozism was defeated by Kantianism? How can Spinoza and Kant be considered as supporting alternative conceptions of social normativity shaping the realm of classical sociology and how does this alternative still operate in contemporary debates on the philosophy of social sciences?
Fertilization effect of Aerosols on earth BIOmass (FABIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-07-01
End date: 2016-06-30
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

Atmospheric aerosols have an important role in the energy balance of earth system, yet not all their interactions have been fully studied, especially the aerosol fertilization effect on the terrestrial and marine ecosystems. This proposal is targeted to quantify the response of natural terrestrial and oceanic productivity to the atmospheric deposition of ammonium aerosol and iron-rich dust particles. It involves the coupling of a global chemistry-aerosol model within an Earth System Model that includes the carbon cycle in the terrestrial and marine reservoirs. In the proposed research, important knowledge will be transferred from the third country (China) to the host institution in France, including a new dataset of gaseous and aerosol species emissions, coupling of aerosol and vegetation models, and simulation of the fertilization effects of aerosols on marine and terrestrial ecosystems. This proposed research is expected to enhance the Earth System Modeling in the host institution and increase European competitiveness in climate change study. This research can lead to potential breakthroughs in our understanding of the influence of nitrogen and iron on carbon storage.

Keywords: fertilization,nitrogen,iron,aerosols,terrestrial and marine productivity,biomass,earth system modeling.
Establishing Precision and Controlling Uncertainties for Multijet Simulations at the LHC (PECULIJETS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-11-01
End date: 2016-10-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

As the Large Hadron Collider probes nature with unprecedented energies and luminosity it is vital to have accurate simulations which can be compared directly with data. This involves incorporating exact calculations at a fixed order in the perturbative expansion with the approximate calculations normally used in simulations of high energy collisions. The PECULIJETS project will develop such simulations by concentrating on the accurate simulation of processes involving photons. These processes are important both in their own right and as the backgrounds to both the production of the Higgs boson and the search for new physics beyond the Standard Model. They are an essential component as we strive for more and more accurate simulations, occurring at approximately the same rate as the second order corrections in the strong coupling and forming a vital part of the full higher order electroweak corrections. The project will achieve this through: the development of state of the art simulations of the production of a photon in association with one or two jets at next-to-leading order (NLO) in the strong coupling constant (WP1); matching in the case that there are both electromagnetic and strong corrections, for example dijet production (WP2); improving multijet merging techniques using the high energy jets formalism, with particular emphasis on assessing the uncertainties involved in such approaches (WP3); incorporating both electromagnetic and strong radiation in multijet merging. All of these objectives build upon each other and will lead to a state-of-the-art simulation of processes involving both electromagnetic and strong corrections. The new simulations will be incorporated with the Herwig++ simulation package so that they can easily be used by the LHC experiments in their analyses and to compare our theoretical predictions and the latest experimental results.

Keywords: nlo qcd corrections,parton showers,lhc phenomenology
Self-Assembling Multivalent Biodegradable Ligands for Nanoscale Heparin Binding (SAMUL-NANO-HEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-01
End date: 2016-09-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

This proposal targets the development of self-assembling nanoscale systems to bind heparin. Heparin is widely used as an anti-coagulant during major surgery, but once surgery is complete, it is necessary to remove the heparin and allow clotting to begin. The current therapy is protamine, a protein extracted from shellfish which acts as a powerful heparin binder, but unfortunately, causes allergic response and other problems in significant numbers of patients (ca. 10%). We are therefore targeting the development of novel synthetic nanoscale protamine replacements which may avoid some of these difficulties. Our unique strategy is to develop small molecules which self-assemble into nanoscale heparin binders. This has the advantage of being highly tunable and uses low molecular-weight (drug-like) building blocks – allowing structure-activity relationship understanding of the binding event to emerge. The self-assembled structures will be optimised in terms of their charge density, morphology, display of functional groups and ability to degrade, to maximise heparin binding and surgical potential. This project will provide fundamental insight into the requirements of an effective heparin binder. Our optimised systems will be tested in clotting and toxicity assays, and may have longer-term applications in a medical setting.

Keywords: nanomedicine,self-assembling,dendrimer,supramolecular chemistry,heparin binder,multivalency
Towards Better Robot Manipulation: Improvement through Interaction (ITHRUI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-03-12
End date: 2016-08-11
Duration (months): 29.0
Total project cost (EUR): 283760.52
EU funding (EUR): 283760.52
Participants: 1
Project status: CLOSED

This project will investigate how learning can be used to improve and expand the manipulation abilities of a robot-out-of-a-box. We argue that, the robot-out-of-a-box should come with both (1) a set of built-in capabilities that would enable it to solve manipulation tasks in unstructured human environment, as well as (2) the learning ability to extend and improve, and with guarantees not to hinder, its capabilities through its interactions over the lifetime of the robot with minimal (none wherever possible) user effort. One major approach towards the development of built-in capabilities for robot manipulation falls under the Sense-Model-Plan-Act (SMPA) paradigm, which relies on the maintenance of a world model built from sensory readings through the use of sensing and action models. The research carried under under this paradigm makes general and conservative assumptions about the robot, the environment as well as the interactions between them and builds models that are guaranteed to provide an optimal level of performance when these assumptions hold. This makes them suitable as built-in capabilities that can be put in “the box”. Another approach that has taken root during the last decade puts emphasis on the embodiment and the situatedness of the robot and focuses on learning through interaction, which falls under the Sense-(Plan)-Act (S(P)A) paradigm. These studies often shy away from the use/building of analytic models of the robot, its environment and interactions between them, and operate mainly the “perceptual space” of the robot. The project will study how methods developed within these different paradigms can be integrated such that the manipulation skills of a robot can be improved through the use of sensory-motor data collected during its interactions.

Keywords: robotics,manipulation,learning,cognitive systems
Intrinsic Complexity of Rule-Based Systems (RUBYX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-12-01
End date: 2017-03-09
Duration (months): 24.0
Total project cost (EUR): 221154.6
EU funding (EUR): 221154.6
Participants: 1
Project status: CLOSED

The RUBYX project will extend the theoretical foundations for the area of rule-based systems used in theoretical computer science to model biological and chemical processes with the aim of extending their areas of application to new areas. Rule-based systems give rise to systems of differential equations that describe the evolution of the biochemical systems modelled, but which are too complex to solve with current state-of-the art algorithms. RUBYX will address this shortcoming by (i) providing a theoretical characterisation of the intrinsic computational complexity of general rule-based systems; (ii) employ techniques from graph rewriting to investigate the optimality of existing techniques from Kappa calculus, and characterise the set of rule-based methods for which optimal methods exist; (iii) provide experimental in silico corroboration of the theoretical results. The RUBYX project aims to further strengthen the leading European position in the theoretical treatment of synthetic biology (the mathematical and computer scientific aspects of which have internationally leading experts in France, Italy and Scotland) by enabling a highly promising junior researcher in the area to interface with leading European experts in computational complexity theory and rewriting (with internationally leading experts in, amongst other countries, Denmark, Germany, and the Netherlands). The long-term strategic benefit to both the applicant and the European research area will be the (a) the establishment of further interaction between distinct areas of theoretical computer science, and (b) the extension and potential empirical verification of theoretical methods developed in Europe in areas of synthetic biology whose practical aspects are currently dominated by scientists in the United States.

Keywords: complexity theory computational systems biology graph rewriting scientific computing
Perovskite-based Hybrid Optoelectronics: Towards Original Nanotechnology (PHOTON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-06-01
End date: 2016-05-31
Duration (months): 24.0
Total project cost (EUR): 199317.6
EU funding (EUR): 199317.6
Participants: 1
Project status: CLOSED

Materials define progress. Organic-inorganic hybrid materials based on the perovskite crystal structure have recently attracted a great deal of attention in the field of new and emerging photovoltaics, where photo-conversion efficiencies of over 15% have been demonstrated (with independent verification at 14.1%). These recent developments are the first examples of a truly low-cost photovoltaic system based on earth-abundant materials yielding efficiencies that are competitive with traditional photovoltaic technologies. It was recently shown that photovoltaics based on hybrid perovskites can operate in a thin-film architecture. The thin-film architecture enables simplified processing, potentially better control, provided the method of processing is carefully chosen, and a greater availability of analytical tools compared to solution processing. Crucially, it is possible to transfer over 30 years of existing, proven thin-film photovoltaic technology into the new system such as photonic management in light-trapping techniques and a whole host of electronic contact engineering knowledge thus rapidly progressing State of the Art. Understanding thin-film formation and properties is paramount to the development of this technology beyond the State of the Art. The application of advanced thin-film deposition techniques such as pulsed-laser deposition allows the formation of atomically smooth films and crucially it allows control over the material stoichiometry and composition, thereby enabling control over material properties. Furthermore, sophisticated instrumentation to monitor thin-film growth in-situ thus allowing the researcher to carefully probe the processes in thin-film formation exists. Another imminent challenge is to gain control over the material crystallisation and film formation, achieving this will lead to better reproducibility thus help devise realistic industrial scale-up strategies

Keywords: thin films,pulsed-laser deposition,pld,energy conversion,energy collection,photovoltaics,solar cell,light-emitting diodes,perovskite,hybrid materials,molecular electronics
Structured Vibrational Environments and Quantum-Coherent Transport in Chiral Systems (QUANTUM VIBES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-11-01
End date: 2017-08-09
Duration (months): 24.0
Total project cost (EUR): 179739.6
EU funding (EUR): 179739.6
Participants: 1
Project status: CLOSED

The last few years have seen a renewed and ever increasing interest into the mechanism of electronic energy transfer (EET) during the first steps of photosynthesis stimulated by surprising experimental findings that indicate that EET in natural light-harvesting complexes may involve long-lived quantum-coherent dynamics. EET is a fundamental process relevant not only for biology but also for many applications based on synthetic molecular aggregates. Thus, establishing design principles that support quantum coherent dynamics of electronic excitation in the noisy vibrational environment typical of supramolecular structures may bring paradigmatic changes to the development of quantum-enhanced technologies. This project is directed at investigating the largely unknown structure-to-function relation in coherent transport. The effect of structured environments, in particular discrete vibrations and the structural organisation of the light-harvesting molecules in sustaining quantum coherent dynamics and aiding EET will be studied in novel artificial systems. EET will be treated within the theoretical framework of open quantum systems in the well-known Quantum Mechanics Group at the University of Trieste under the supervision of Dr. A. Bassi. Despite the theoretical nature of the project, the research will have a strong experimental connection by focusing on experimentally relevant synthetic chiral systems that will be subject to spectroscopic studies in the group of Dr. E. Collini at the University of Padova. The IEF program will allow the fellow to be immersed in an international top-class research environment and carry out a truly interdisciplinary research. The competencies gained and collaborations established during the fellowship will strengthen the scientific career of the fellow and contribute towards the fellow’s aim of a long-term research career in Europe. It will thus be beneficial for the fellow and for Europe’s research excellence.

Keywords: p314 physical chemistry of biological systems,open quantum systems,quantum physics,electronic excitations