Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identify and detect key ocular biomarkers towards personal medicine (BIOCUDET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: France
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-29
End date: 2018-09-28
Duration (months): 12.0
Total project cost (EUR): 89375.0
EU funding (EUR): 89375.0
Participants: 1
Project status: CLOSED

In the EU, the costs of ocular diseases amount to 70% of the costs induced by cancer. This is bound to increase as our population ages, especially as most costs result from late or wrong diagnosis. The current ocular disease diagnostic devices are far from delivering the expected performance. The concomitant discovery of biomarker candidates for several major eye diseases and development of fast multiplex quantitative PCR (qPCR) technology offers the unique opportunity to propose a Point of Care Test (PoCT) able to fulfil modern ocular diagnostics needs. By hiring an Innovation Associate with an expertise in ophthalmology and microbiology, ELVESYS wants to develop the first fast and affordable biomarker based PoCT device for the ocular disease diagnostics market. This system will enable any practitioner to propose a diagnosis based on the simultaneous measurement of ocular disease biomarkers in less than 10 minutes. This system will offer the capacity of simultaneous diagnosis of main ocular diseases in a single test during the time of a visit to the doctor’s office. The Innovation Associate will benefit from ELVESYS expertise in the world fastest multiplex qPCR system and OPIA expertise of conjunctiva sampling to develop this first prototype. The BIOCUDET project is today the most relevant in the world to bring a PoCT system to the market within the next couple of years to address with success this major social and economic concern. This system will give ELVESYS the highest competitive advantage on a global total admissible market of €3.5 billion per year by 2025. This PoCT is today the key solution to alleviate the medical and social issues of ocular diseases that weighs more than €86 billion annually on the EU healthcare systems. This project will also allow ELVESYS to train an Innovation Associate in entrepreneurship so that they can later become part of the team or start their own spin-off company to commercialize the PoCT system developed.

Keywords: dry eye disease,conjunctivitis,endophthalmitis,ocular disease diagnosis and monitoring,ultrafast multiplex rt qpcr,microfluidic device,point of care test,ocular disease biomarkers
Asymmetric Copper Catalyzed Multicomponent Coupling (CuCAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The development of operationally simple methods for the rapid and efficient, catalytic construction of high value products from simple starting materials is key to the future of synthetic science. Moreover, if high value chiral products can be assembled from several readily available achiral components in a one-pot process then diverse collections of important compounds can be quickly constructed by simple variation of the material inputs. Even more challenging, but attractive to the scientific community, would be a multicomponent process catalyzed by a low-cost metal using a commercially-available ligand to control the regiochemistry and relative and absolute stereochemistry of the cross-coupling process. In this project we will develop one-pot processes involving imines that deliver important, functionalized amine products that are hard to make using the current state-of-the-art in synthesis. In particular, we will develop the enantioselective union of imines, allenes, and boron–X components, mediated by an inexpensive, readily available copper catalyst, which delivers versatile functionalized homoallylic amines that are privileged substructures in bioactive compounds and flexible building blocks for the construction of other biologically-significant motifs. For example, the brand new methodology will be applied in the target synthesis of validated bioactive molecules and in the rapid generation of libraries for medicinal chemistry exploration. The action will also open new vistas for other enantioselective multicomponent couplings using this approach. This ambitious project will expose Dr. Manna to new areas of physical techniques as well as provide high level synthetic training, which in addition to transferable skills gained, will place him in a uniquely strong position to advance in his career.
ACCELERATing Europe's Leading Research Infrastructures (ACCELERATE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Ukraine,Germany,Germany,Italy,Sweden,Czechia,Czechia,Netherlands,United Kingdom
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3325757.0
EU funding (EUR): 3325755.0
Participants: 11
Project status: CLOSED

CERIC-ERIC (CERIC) is a distributed research infrastructure for fundamental and applied research on novel materials and biomaterials. The RI has been in operation for 2 years and provides open access to a broad range of instruments and expertise across research communities, in order to support the research community world-wide in tackling the most challenging problems of materials research. The ACCELERATE project is proposed to support CERIC sustainability through activities of collaborative development of policies with other research infrastructures (RIs), in particular new and forming ERIC entities. ACCELERATE will assist sustainability, relevance and effectiveness of the RI through preparation of frameworks for services to private and public entities, outreach to new scientific and industrial networks and geographical areas and a methodology for RI social impact assessment. Together with the RI partners CERIC will also carry out several intense courses for development of future RI managerial, IL and TT staff. The project will be carried out while maintaining vigorous communication with research and industrial communities, policy makers, EC administration and other RI stakeholders.

Keywords: european research infrastructure consortium,social return,socio economic impact
Using Phase Change Materials for the Base Suspension in the Creation of NanoFluids (PCMNano)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-08-27
End date: 2020-08-26
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Nano-fluids (fluid bases with a nano-particle suspension) and Phase Change Materials (PCM) provide innovative ways to handle the increased need for heat transfer and thermal efficiency. But information regarding the thermal properties (thermal conductivity, thermal diffusivity, enthalpy of transformation, enthalpy of fusion/melting, enthalpy of vaporization, specific heat, melting temperature, and crystallization temperature) of nano-fluids and PCMs is limited and antiquated. Therefore, is the purpose of this action to determine the thermal properties of a number of PCMs to then use as the base fluid for a number of nano-fluids. This will be done by measuring n-alkanes in both the solid and liquid phases using the transient hot wire and the differential scanning calorimetry (DSC) techniques. When possible, the obtained results will be compared with the scarcely available literature data. Lastly, the creation of a thermal properties prediction model for the nano-fluids will be attempted.

Keywords: phase change materials,thermal properties,nanofluids,nano particles,fluid properties
5G experimentation environment for 3rd party media services (5GMediaHUB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: 5G PPP (cPPP)
Countries involved: Ireland,Germany,Spain,Italy,Spain,Ireland,Cyprus,Norway,Switzerland,Norway,Greece,Greece,Switzerland,Norway,Greece,France
Call: 5G PPP – 5G innovations for verticals with third party services (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 7566195.89
EU funding (EUR): 6037942.38
Participants: 20
Project status: SIGNED

5GMed5GMediaHUB aims to help EU to achieve the goal of becoming a world leader in 5G, by accelerating the testing and validation of innovative 5G-empowered media applications and NetApps from 3rd party experimenters and NetApps developers, through an open, integrated and fully featured Experimentation Facility. This will significantly reduce not only the service creation lifecycle but also the time to market barrier, thus providing such actors that are primarily from SMEs, with a competitive advantage against their rivals outside EU. In particular, 5GMediaHUB will build and operate an elastic, secure and trusted multi-tenant service execution and NetApps development environment based on an open cloud-based architecture and APIs, by developing and integrating a testing and validation system with two existing well-established 5G testbeds (by CTTC and Telenor) for enabling the fast prototyping, testing and validation of novel 5G services and NetApps. 5GMediaHUB will offer: (i) a DevOps environment for Testing as a Service; (ii) a rich set of Experimentation Tools that offer scheduling, validation, verification, analytics and QoS/QoE monitoring mechanisms; (iii) A set of re-usable vertical-specific and vertical-agnostic NetApps with easy to use APIs that can be consumed by application developers, reducing the complexity and risk of integrations and operations; (iv) a re-usable open-source NetApps Repository; (v) an umbrella cross-domain service orchestrator to deliver cross-domain orchestration of NetApps; (vi) an innovative security framework offering software defined perimeter protection and isolation of NetApps; (vii) incremental validation capabilities of the Experimental Facility evidenced through 3 novel media use cases with 2 scenarios each, over 3GPP R.16 and R.17 5G testbed releases. Our 17-partner consortium (9 SMEs) from 9 countries has extremely rich 5G-PPP experience, since 13 partners have participated in previous 5G-PPP projects and in several 5G-PPP WGs.

Keywords: media,netapps,experimentation facility,3rd party experimenters,3rd party netapps developers,5g networks,artificial intelligence,field trials,3gpp r 16,r 17
World's first mobile power grid and business ecosystem to support it (PAWA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

68% of people in Sub-Saharan Africa currently live with very limited access to energy. In these unserved areas, electricity is expensive and difficult to access. Decentralized power generation projects (based on renewable energies) could be the key to unlocking the electrification challenge. These projects, however, have yet to develop business models that are genuinely sustainable over the long term. The most feasible technology, based on solar power is facing limited spread. Solar panels are not often available; they are too costly, fixed to a location or impractical to move and require maintenance. Pawa Technologies mission is to create the world’s first off-grid power eco-system turning people into power consumers, traders and producers - as a business, not by aid. Pawa is marketed towards people living in rural communities without access to the electric grid. Sub-Saharan Africa is a 600 million people market representing a €60 billion turnover. Pawa gives our target end users, the option to become power producers and sell excess power. For just a simple mobile phone charging micro-business, Pawa cost is recovered in less than 6 months and afterwards generates a steady income to the business owner, while granting savings in phone charges to their own neighbours. Pawa Technologies is a dynamic start-up backed by Moonwalk, an incubation company with over 10 companies in its portfolio, devoted to address social and sustainability challenges. Moonwalk companies have created 23 jobs in 2 years and are growing in 3 continents. In June 2016, Pawa entered the market place to pilot the Pawa prototypes. Kenyan customers pre-bought over 350 Pawa Introductory packages in less than 5 Hours. Currently, Pawa Package version 4 has entered trial production. At this point, we are situated to conduct product optimization that will reduce the cost, extend market presence in Kenya and penetrate additional countries in Sub-Saharan Africa.

Keywords: sustainable energy,local supply,portable solar pannel
Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Australia,Switzerland,Switzerland,Sweden,France,France,Netherlands,Netherlands,United States,United Kingdom,Denmark,United Kingdom,Denmark,United Kingdom
Call: Vaccine development for malaria and/or neglected infectious diseases (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 23741228.75
EU funding (EUR): 20050441.25
Participants: 22
Project status: SIGNED

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in an exciting programme of antigen discovery science linked to rapid clinical development of new vaccine candidates. Our approach tackles the toughest problems in malaria vaccine design: choice of the best antigens, attaining high immunogenicity, avoiding polymorphic antigens and increasing the durability of vaccine immunogenicity and efficacy. We take advantage of several recent advances in vaccinology and adopt some very new technologies: sequencing malaria peptides eluted from the HLA molecules, parasites expressing multiple transgenes, multi-antigen virus-like particles constructed with new bonding technologies, delayed release microcapsules, and liver-targeted immunisation with vaccine vectors. We enhance our chances of success by using a multi-stage multi-antigen approach, by optimising the magnitude and durability of well-characterised immune responses to key antigens, and using stringent infectious challenges and functional assays as established criteria for progression at each stage. The consortium comprises many of the foremost researchers in this field in Europe with leading groups in the USA, Australia and Africa. We link to EDCTP programmes and harmonise our timeline to fit with the recent roadmaps for malaria vaccine development. We include a major pharma partner and several excellent European biotech companies helping enhance Europe’s leading position in the commercial development of vaccines. This ambitious and exciting programme should have a high chance of success in tackling the major global health problem posed by malaria.

Keywords: sporozoite stage,liver stage,blood stage,transmission blocking,virus like particle,plasmodium falciparum,spycatcher,multi antigen,antigen discovery,adjuvant
Fluorescent-based innovative measure in thin liquid films: A way to understand stability and energy dissipation in foams and emulsions (DISFILM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1415506.0
EU funding (EUR): 1415506.0
Participants: 2
Project status: SIGNED

Nobody knows why a soap bubble collapses. When the liquid film forming the bubble, stabilised by surfactants, becomes too thin, it collapses. This seemingly simple problem, ruled by the classical laws of fluid mechanics and of statistical physics, is still a challenge for the physicist. The rupture criteria based on a stability analysis in the vicinity of the film equilibrium state fail to reproduce the observations. However the film ruptures in a foam obey some simple phenomenological laws, which suggest that underlying fundamental laws exist and wait to be determined. The state-of-the-art conjecture is that ruptures are related to hydrodynamical processes in the films, a field in which I have now an international leadership. Recent experimental data I obtained open the possibility to address this question using a fully non-linear approach in the far from equilibrium regime. In this aim, DISFILM will develop an innovative technique to measure the interface velocity and surfactant concentration, based on the use of fluorescent surfactants. The risk relies in the adaptation to dynamical conditions of advanced optical techniques. These quantities have never been measured on flowing interfaces yet, and my technique will be an important breakthrough in the field of free interface flows in presence of surfactants. A set-up will be designed to reproduce on few thin films the deformations occurring in a foam sample. The dynamical path leading to the rupture of the film will be identified and modelled. The results obtained on an isolated film will be implemented to predict the 3D foam stability and the approach will be extended to emulsions. Foams and emulsions are widely used in industry and most of the stability issues have been solved. Nevertheless, most of the industrial formulations must currently be modified in order to use green surfactants. This adaptation will be extremely more efficient and possible with the results of DISFILM as a guideline.

Keywords: bubbles,drops,foam,emulsion,liquid film stability,free interface flow,surfactant transport,energy absorption,complex fluid
Improved Credentialess and Secure Cloud Access (EPICA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-10-01
End date: 2022-03-31
Duration (months): 30.0
Total project cost (EUR): 2928065.0
EU funding (EUR): 2049645.5
Participants: 1
Project status: CLOSED

PrivX is a new generation solution that brings Privileged Access Management (PAM) to the cloud era. During its 25-year history of innovation, SSH.COM has developed strong customer and analyst relationships and gained deep insight into customer needs. A key conclusion is that the traditional PAM approach is incompatible with the requirements of cloud and hybrid environments. Customers have indicated that current 1st generation PAM systems are cumbersome to deploy, inflexible to scale, expensive to create sufficient return-on-investment, and difficult for administrators and end-users to effectively use. These systems have become a bottleneck in cloud transformation as their technology foundation is not suitable for the immense flexibility and dynamism required by cloud environments. PrivX is built from the ground up to meet and grow with the demands of the cloud. By providing credentialess, role-based, on-demand access to cloud and hybrid resources, PrivX removes a key bottleneck from cloud adoption. PrivX enables companies to accelerate their cloud transformation they must undertake to take advantage of new growth opportunities and to stay competitive in the new digital economy. SSH has a global customer base of 3000 companies and a demonstrated ability to sell to large enterprises. SSH will also sell the product online to SME customers and recruit both cloud service providers and Identity-as-a-Service solution providers to be resellers of PrivX. This will accelerate market entry and allows SSH reach a larger customer base. The proposed work will allow SSH to complete the development of the PrivX product family, build necessary interfaces to create a vibrant ecosystem around the product, and take it to the markets. Europe has fallen behind the US, Israel, and China in cyber security development investment and innovation and homegrown projects such as PrivX are crucial in helping to narrow the gap and increase the competitiveness of the EU cyber security.

Keywords: cloud architecture,privileged access management,privileged identity management,cyber,security,authentication,ssh client