Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity (PolarNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Switzerland,Belgium,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 3935968.56
EU funding (EUR): 3935968.5599999996
Participants: 13
Project status: CLOSED

The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell polarity requires knowledge of the molecular players involved and a quantitative description of their biochemical interactions, as well as the mechanical processes underlying polarity establishment. PolarNet brings together academic and private partners from 7 European countries to establish a multidisciplinary, intersectoral training and research programme that will study the basic principles of cell polarity. The research will combine complementary model systems ranging from fungi and cultured mammalian cells to whole organisms, and employ a broad set of approaches such as advanced genetics, protein biochemistry, high-resolution live imaging and image analysis, biophysics and theoretical modelling. This setting provides an opportunity to train early stage researchers in a unique combination of experimental and theoretical approaches. This will provide an excellent starting point for a successful career in the rapidly expanding field of multidisciplinary or ‘integrative’ biology. Training Europe’s next generation of scientists at the forefront of cell and organismal polarity research is crucial for progress in several medically important fields, including cancer research and stem cell biology. The tight collaboration with non-academic partners will strengthen the technological base of different projects and provide early stage researchers with insights into the translation potential of the performed studies and the career development opportunities in biomedical industry.

Keywords: cell polarity
GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OF INFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA (INFANTLEUKEMIA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Infant cancer is very distinct to adult cancer and it is progressively seen as a developmental disease. An intriguing infant cancer is the t(4;11) acute lymphoblastic leukemia (ALL) characterized by the hallmark rearrangement MLL-AF4 (MA4), and associated with dismal prognosis. The 100% concordance in twins and its prenatal onset suggest an extremely rapid disease progression. Many key issues remain elusive: Is MA4 leukemogenic? Which are other relevant oncogenic drivers? Which is the nature of the cell transformed by MA4? Which is the leukemia-initiating cell (LIC)? Does this ALL follow a hierarchical or stochastic cancer model? How to explain therapy resistance and CNS involvement? To what extent do genetics vs epigenetics contribute this ALL? These questions remain a challenge due to: 1) the absence of prospective studies on diagnostic/remission-matched samples, 2) the lack of models which faithfully reproduce the disease and 3) a surprising genomic stability of this ALL. I hypothesize that a Multilayer-Omics to function approach in patient blasts and early human hematopoietic stem/progenitor cells (HSPC) is required to fully scrutinize the biology underlying this life-threatening leukemia. I will perform genome-wide studies on the mutational landscape, DNA and H3K79 methylation profiles, and transcriptome on a uniquely available, large cohort of diagnostic/remission-matched samples. Omics data integration will provide unprecedented information about oncogenic drivers which must be analyzed in ground-breaking functional assays using patient blasts and early HSPCs carrying a CRISPR/Cas9-mediated locus/allele-specific t(4;11). Serial xenografts combined with exome-seq in paired diagnostic samples and xenografts will identify the LIC and determine whether variegated genetics may underlie clonal functional heterogeneity. This project will provide a precise understanding and a disease model for MA4+ ALL, offering a platform for new treatment strategies.

Keywords: infant leukemia,developmental cancer,mll af4 fusion,multilayer omics,developmental early stem cells,genome engineering,crispr cas9,leukemia initiating cell,subclonal functional heterogeneity
Geographic mapping of radio signals (MapCOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-01-01
End date: 2016-12-31
Duration (months): 12.0
Total project cost (EUR): 150000.0
EU funding (EUR): 66250.0
Participants: 2
Project status: CLOSED

MapCOM will transition the fundamental research carried out in the COOPNET project (the PI’s Starting Grant Project) to concrete applications related to power-efficient and scalable resource allocation for cellular networks, in particular for 5G communications. The key idea is to harness uncertain location information to build statistical radio maps, which can be used to predict radio signal quality and perform long-term proactive resource allocation. This will reduce operating costs for operators, provide better user experience for high-throughput applications, and enable new services and applications where low latency, reliable, and scalable communication is key (e.g., autonomous vehicles). Our COOPNET research has indicated the importance of explicitly accounting for various sources of uncertainty. We are now ready to establish the innovation potential of this research for commercial and societal benefit. Funded by the Western Sweden Innovation Office, we have already taken initial steps in this direction and have established possible innovation potential through meetings with Ericsson and Alcatel-Lucent, two equipment manufacturers. In this ERC Proof of Concept, we plan to demonstrate the technology and determine the market potential by: (i) confirming that the performance gains seen in theory also hold up in the real world; (ii) identifying possible market applications starting with telecom equipment manufacturers and telecom operators, but also other ICT industries. This analysis will allow us to identify, together with industrial actors, where the market value of the COOPNET concept lies. If successful, telecom equipment manufacturers and/or telecom operators will be able to provide the COOPNET functionality as part of their future products and services, giving them a significant advantage over competitors. We also expect this to be a first step towards multiple possible market applications to be identified in various areas of the ICT industries.

Keywords: 5g communication,crowd sourcing,radio mapping,network optimization
Breaking the paradigm: A new approach to understanding and controlling combustion instabilities (TAIAC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Norway
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1929103.26
EU funding (EUR): 1929103.26
Participants: 1
Project status: CLOSED

It is well known that current and future low-emission combustion concepts for gas turbines are prone to thermoacoustic instabilities. These give rise to large pressure fluctuations that can drastically reduce the operable range and threaten the structural integrity of stationary gas turbines and aero engines. In the last 6 years the development of laboratory-scale annular combustors and high-performance computing based on Large Eddy Simulations (LES) have been able to reproduce thermoacoustic oscillations in annular combustion chambers, giving us unprecedented access to information about their nature. Until now, it has been assumed that a complete understanding of thermoacoustic instabilities could be developed by studying the response of single axisymmetric flames. Consequently stability issues crop up far into engine development programmes, or in service, because we lack the knowledge to predict their occurrence at the design stage. However, the ability to experimentally study thermoacoustic instabilities in laboratory-scale annular combustors using modern experimental methods has set the stage for a breakthrough in our scientific understanding capable of yielding truly predictive tools. This proposal aims to break the existing paradigm of studying isolated flames and provide a step change in our scientific understanding by studying thermoacoustic instabilities in annular chambers where the full multiphysics of the problem are present. The technical goals of the proposal are: to develop a novel annular facility with engine relevant boundary conditions; to use this to radically increase our understanding of the underlying physics and flame response, paving the way for the next generation of predictive methods; and to exploit this understanding to improve system stability through intelligent design. Through these goals the proposal will provide an essential bridge between academic and industrial research and strengthening European thermoacoustic expertises.
HyFast - Fast hydrogen fueling and long range for fuel cell vehicles (HyFast)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 2856367.5
EU funding (EUR): 1999457.25
Participants: 1
Project status: CLOSED

The purpose of the HyFast project is to finalize development and conduct a test of a full-scale prototype for a new H2Station® product from H2 Logic. H2Station® is a Hydrogen Refueling Station that already today is providing fast 70MPa hydrogen fueling for fuel cell electric vehicles (FCEV) from major car manufacturers. The new H2Station® technology has prior to the HyFast project reached a TRL5 level through extensive R&D for more than €3 million. This effort represents a “Phase 1” which has been conducted through several projects supported by national R&D programs and the European FCH-JU program. The HyFast project acts as the “Phase 2” where the H2Station® technology is to reach a TRL8 level enabling market introduction. The H2Station® technology is developed in collaboration with a EU supplier base of 73 companies from 10 countries. With HyFast the present EU supplier share of 62% of the cost basis of a H2Station® is to be increased to 80%. Additionally several key market stakeholders such as Toyota, BMW, Hyundai, Siemens and Shell will provide market input and serve as later market entry platforms. With the HyFast project capacity and performance is to be increased and cost reduced to a level that enables commencing of market introduction in Europe during 2017 and for USA and Japan during 2018-2019. HyFast is in particular to increase fueling capacity to a level that corresponds to what is achieved on an average gasoline dispenser. This will be paramount for achieving a profitable roll-out and operation of networks of hydrogen fueling stations. Further footprint of the technology is to be reduced to enable integration at conventional gasoline stations. HyFast is to achieve the EU FCH-JU program 2020 CAPEX target of €0.8 million for at turn-key hydrogen fueling station already by 2017. This will enable a supported station roll-out where public support levels required for a payback is within the funding levels of existing programs in EU, USA & Japan.

Keywords: fuel cell electric vehicles,hydrogen refueling stations
Disrupting the European domestic space heating market with the lowest cost, energy-efficient Gas Heat Pump (GasHeatPumpSaltX)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Sweden
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 2828875.0
EU funding (EUR): 1980212.0
Participants: 1
Project status: CLOSED

Swedish SaltX, a listed 5m EUR revenue company, has identified a growth opportunity in the 7m units/yr European domestic space heating appliance market to deploy its patent protected storage technology SaltX. Experts forecast fast traction for gas heat pumps (GHP) in this market over the next few years, mainly driven by more stringent regulation for energy efficiency. A Phase I feasibility study by Fraunhofer ISE, the highly respected GHP experts, confirmed that the SaltX’s TRL6 prototype is indeed the most energy efficient and low-cost solution among GHPs: SaltX-GHP will be the only GHP system that can compete with condensing gas boilers for some time, whilst the high cost and bulkiness of competitive GHPs restrict them to premium niche segments. The final system will increase energy efficiency compared to gas boilers by up to 40%, saving households up to 500 EUR/year in natural gas expenses. The system will be priced at a 15-20% premium to condensing gas boilers, or 750 EUR a unit, at an attractive 1.5 years pay-back. The efficiency advance is enabled by SaltX’s innovation that uses nano-coated salt + matrix as a heat storage medium – both are protected by patents. SaltX has already licensed this technology in the thermal solar and truck air-conditioning markets, booking early revenues of 5m EUR in 2016. In this project, SaltX will build and demonstrate a pilot GHP system. SaltX’s efforts to create momentum with OEMs via gas utilities, e.g Gas de France and British Gas, who are keen to promote gas driven innovation, has started to bear fruit. SaltX has now received strong interest from OEMs, such as Vaillant and NIBE, who will receive regular progress updates during Phase II. Following completion, SaltX will deliver on joint development agreements with OEMs, agreed upon during Phase II, and launch its GHP to a significant portion of the 7m unit a year European gas boiler market, aiming at revenues of 225m EUR by 2024 and total job creation of 30

Keywords: gas heat pump,domestic space heating,salt based storage,energy storage,nano coated salt
Remotely-controlled functional synthetic tissues (SYNTISU)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-08-01
End date: 2025-07-31
Duration (months): 72.0
Total project cost (EUR): 2428065.0
EU funding (EUR): 2428065.0
Participants: 1
Project status: SIGNED

We will make synthetic tissues for applications in medicine. In the short-term, synthetic tissues will be used to deliver therapeutics; ultimately, synthetic tissues will be used as components of surgical implants. The synthetic tissues will be formed from patterned 3D-printed picoliter droplet networks. They will be functionally active and subject to external control. They will be safe, because they cannot replicate. Key aspects of synthetic tissues, which were introduced by our laboratory, remain unexplored. At this point, our initial work justifies an adventurous full research program. The capabilities of biological tissues greatly exceed those of individual cells, because the cells in them cooperate to produce emergent properties. Our approach considers, but does not strictly mimic nature. 3D printers make patterned networks of picoliter droplets, separated from each other by individual lipid bilayers, which can be functionalized with membrane proteins to allow internal and external communication. In early work, we showed that droplet networks can change shape and transmit electrical signals. Now, we will greatly extend the properties of these materials. We will produce synthetic tissues with excellent fidelity, at high resolution, with faithful patterning and of superior strength and stability. Hierarchical cm-scale structures will be assembled from mm-scale networks. We will make functional tissues able to change shape rapidly and reversibly, take up, transform and release molecules, and generate and use energy. Functional synthetic tissues will be controlled remotely with light, heat, and magnetism. Outputs will include ATP generation and protein expression. Finally, we will explore two illustrative applications of synthetic tissues: the controlled synthesis and release of therapeutic peptides, and the ability to modulate the activities of neurons and muscle cells. Discoveries derived from this ERC grant will be commercialized with investor funding.

Keywords: synthetic tissue,synthetic cell,artificial cell,lipid bilayer,droplet interface bilayer,3d printing,emergent properties,membrane channels and pores
Industrial Modular Battery Pack Concept Addressing High Energy Density, Environmental Friendliness, Flexibility and Cost Efficiency for Automotive Applications (iModBatt)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Austria,Austria,Austria,Germany,Spain,Türkiye,France,France,France,France,France,Luxembourg
Call: Physical integration of hybrid and electric vehicle batteries at pack level aiming at increased energy density and efficiency (H2020-GV-2017, 2017)
Start date: 2017-10-01
End date: 2021-03-31
Duration (months): 42.0
Total project cost (EUR): 6101973.73
EU funding (EUR): 5058294.01
Participants: 16
Project status: SIGNED

iModBatt stands for Industrial Modular Battery Pack Concept Addressing High Energy Density, Environmental Friendliness, Flexibility and Cost Efficiency for Automotive Applications. The aim of iModBatt is to design and manufacture, with minimum environmental impact, a high energy density modular battery pack flexible enough to be used in automotive and small stationary applications. This battery pack will be suitable for industrial automated assembly with an easy disassembly design, to make possible the shift from primary applications to secondary ones, and to facilitate the pack recyclability or parts replacement if necessary. The project concept is built around an already existing technologically breakthrough, modular battery pack design primarily developed for specialty applications, that has proven excellent performance and cost efficiency in such a manner that higher ambition, wider spread electric vehicle applications seem the natural next developmental step for such a concept. The project focuses into maximization of the energy density of a lithium ion pack through the optimization of the structural design and components of a battery pack for a given cell form factor. In this sense the strategy is to increase the energy density by reducing the weight of the battery pack while keeping structural integrity and easy assembly and manufacturing. Chemistry and BMS work is beyond the scope of the project, which focuses in the structural design and manufacturing. The Consortium includes industrial partners of every step of the battery pack value chain, including automotive OEMs, battery parts manufacturers as well as leading European research centres with ample experience in the field of batteries.

Keywords: modular battery pack,breakthrough,design,manufacturing,energy density,mechanical integration
The Motor Representation of Sensory Experience (moreSense)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2023-09-30
Duration (months): 66.0
Total project cost (EUR): 1494058.75
EU funding (EUR): 1494058.75
Participants: 1
Project status: SIGNED

How do we experience the visual world around us? The traditional view holds that the retinal input is analyzed to reconstruct an internal image that generates our perceptual experience. However, a general theory of how visual features are experienced in space and time is lacking. The fundamental claim of this grant proposal is that only motor knowledge - i.e. the way we interact with the world - establishes the underlying metric of space and time perception. In this model view, the spatial and temporal structure of perception is embedded in the processing of neural motor maps. The project moreSense has four major objectives: First, it will unravel how neural motor maps provide the metric for the experience of visual space. It will be hypothesised that there is no central neural map of space or time but a weighted contribution of all maps. Novel experimental techniques are required to uncover the motor basis of perception, which are available by recent developments in head-mounted displays and online motion tracking. Second, it will provide a general understanding of time perception being implicitly coded in movement plans to objects in space. Third, results from the first two objectives will be applied to the long-standing mystery of visual stability and continuity across movements. A bayesian model, supported by quantitative measurements, will demonstrate how information combination from the various motor maps leads naturally to stable and continuous perception. Fourth, this new theory of space and time perception will be investigated in patients suffering from a breakdown of space perception. The results will establish causal evidence that space and time perception are generated by processing in motor maps. New rehabilitation procedures will be developed to re-establish spatial perception in these patients. The experiments in this grant proposal will unravel the fundamental spatiotemporal structure of perception which organizes our sensory experience.