Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scalable Control Approximations for Resource Constrained Environments (SCARCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1998500.0
EU funding (EUR): 1998500.0
Participants: 1
Project status: SIGNED

This project aims at making a breakthrough contribution in optimal control and decision making for nonlinear processes that take place on network structures and are dynamic in time and/or space. The setting has a wide range of potential domains of applicability, comprising thermal, electric, or fluid dynamics in energy networks, logistics, disease spreading dynamics, or cell signalling in biomedicine. The project will pursue the following objectives: To contribute new theory, to develop numerical approximation methods, to implement algorithmic methods in software, and to conduct proof-of-concept studies. Research in the young field of mixed-integer optimal control (MIOC) has recently seen increased momentum together with numerical approximation algorithms and control theory. Despite initial successes, key questions remain unsolved because of a lack of analytical understanding, a lack of tractable formulations, the unavailability of efficient solvers or the insufficiency of existing implementations. This project focuses on pivotal but poorly understood topics: decomposition, relaxation, and approximation; domains admitting homogenization and limiting processes using weak topologies; tractable approximations of direct costs of decisions; efficient distributed and parallel nonlinear solvers; and robustness of approximate nonlinear decision policies under uncertainty. These key issues appear systematically in a wide range of control tasks of high societal relevance. By addressing them, the project helps to bridge a persistent and pronounced gap in simulation & optimization practice. Due to non-trivial interactions emerging in theory and the unavailability of comprehensive algorithms, these topics cannot be suitably handled by merely combining the respective states of the art. A focused effort to decisively extend MIOC to optimal decisions for dynamics on networks is therefore a timely endeavour that will help to address the challenging demands of practitioners.
Getting to grips with AAA+ ATPases encoded by positive-strand RNA viruses (PicAAA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1550000.0
EU funding (EUR): 1550000.0
Participants: 1
Project status: SIGNED

Noroviruses (NoVs) and enteroviruses (EVs) cause numerous gastrointestinal and respiratory infections. Their contagious nature and high mutation rates can lead to the emergence of new pathogenic strains. Understanding these viruses is crucial for controlling outbreaks and to maintain global health. Both NoVs and EVs are members of the order Picornavirales and share commonalities in their replication strategies. Their positive-strand RNA genomes encode non-structural proteins (NSPs) that exploit host cells to create membranous replication organelles for genome replication and virion formation. The most enigmatic NSP encoded by these viruses is a AAA+ ATPase (NoV NS3 and EV 2C). These enzymes have many proposed roles in the virus lifecycle, such as RNA helicase/chaperone activity, membrane rearrangement, and genome encapsidation. However, their structure and the molecular basis for their diverse activities are poorly understood due to challenges in producing stable and soluble complexes for structural analysis and the lack of tools to accurately visualize NSPs in a cellular context. Drawing from my decade-long experience in structural virology and recent success in engineering soluble AAA+ ATPases, I aim to unravel the multiple functions of NoV NS3 and EV 2C. Specifically, I will: 1) Decipher the structure-function relationship of these enzymes through single-particle cryo-electron microscopy analysis of the nucleotide and RNA-bound complexes. 2) Create a toolkit of small molecules and nanobodies to investigate the functional sites in NS3. 3) Utilize cryo-electron tomography to visualise NS3 and 2C in infected cells, guided by genetically encoded tags developed in this project. Collectively, the results of this project will provide new mechanistic insights into the functions that NoV and EV AAA+ ATPases carry out during the viral lifecycle and pave the way for the development of novel antiviral compounds capable of inhibiting these functionally indispensable enzymes.

Keywords: aaa atpase,helicase,positive strand rna virus,viral replication,cryo em,cryo et,norovirus,enterovirus
Bone Marrow-on-Chip as smart sensor of lung cancer relapse (BuonMarrow)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Spain,Sweden
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 2999835.0
EU funding (EUR): 2999835.0
Participants: 4
Project status: SIGNED

In the past 40 years the overall survival rate for people affected by tumors has doubled, with about 50% of patients now surviving their disease for 10 years or more. Nonetheless, some cancers (e.g lung cancer) still have poor survival rate. A major cause of lung cancer mortality is represented by disease relapse, occuring when few of the original cancer cells survive the initial treatment and causing primary tumor recurrence. Currently, no options are available to predict the risk of lung cancer relapse, which is only diagnosed late based on radiological evidence. Hence, the ability to early detect lung cancer relapse represents an urgent and unmet need, since a fast and tailored treatment could dramatically increase patients’ survival rate. BuonMarrow lays on the groundbreaking hypothesis, supported by our Consortium preliminary clinical evidence, that bone marrow mesenchymal stromal cells (BM-MSC) may be educated upon cancer mediators exposure, and acquire a long-term memory-like response which is amplified when exposed to a secondary tumor. Owing to breakthrough technologies available in the Consortium (organ-on-chip, innovative optical sensors and biological modeling of the bone marrow niche), BuonMarrow partners will develop an in vitro miniaturized bone marrow device able to harness the amplified BM-MSC response generated by liquid biopsy of lung cancer patients, thus acting as a biological sensor for the early detection of relapse. A combination of retrospective and prospective clinical studies, respectively, will allow to calibrate and validate such sensor, delivering an unprecedented tool to assist the decision-making process on lung cancer patients. We expect to significantly improve oncological treatments, building on a personalized medicine approach to increased patient survival and well-being, and thereby deeply impacting on EU’s socio/economic environment.

Keywords: organ on chip,lung cancer relapse,bone marrow niche,tissue engineering,biosensors
Bio-inspired 3D bioelectronic model of the intestinal crypts (BioElectroCrypt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Organ-on-a-chip (OOC) technology represents an important tool in the field of molecular biology, offering a platform that mimics the complex structure and function of human organs in a controlled laboratory setting. These systems have the potential to host biologically complex 3D cell co-cultures, allowing researchers to study cellular behavior in a more physiologically relevant environment compared to traditional 2D models. Due to their ability to closely mimic human physiology, these systems are rapidly gaining popularity, as they exhibit high predictive power for clinical outcomes and may one day replace the use of animal models. The central aim of the proposed project is to increase the biological complexity of bioelectronic intestine-on-a-chip models by incorporating the tissue structures, cell types, and microbes essential for healthy gut function. The first objective is to 3D print a conductive polymer scaffold that recapitulates the 3D structure of colonic crypts and the microporous architecture of the extracellular matrix. This scaffold will be integrated into the E-transmembrane, a device developed by the Owens group at the University of Cambridge, and validated using a cell line model of the intestinal epithelium. The second objective involves replacing the cell lines with dissociated primary intestinal organoids on the 3D scaffold to achieve the epithelial cellular diversity of the gut and form a stem cell niche at the base of the crypts. Finally, human whipworm will be introduced into the model to further understand parasitic infections in the gut. Through the combination of molecular assays, imaging techniques, and electrical measurements, insights will be gained into the complex interactions between cells, parasites, and biomaterials within the OOC system. Overall, this project aims to advance the capabilities of OOC technology for studying gut physiology, disease mechanisms, and drug responses in a more physiologically relevant context.
Starting the Sustainable 6G SNS Initiative for Europe (6GStart)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Coordination and support actions
Countries involved: Germany,Belgium,Sweden,Norway,France,Spain,Italy,Portugal,Finland,United Kingdom,Netherlands,Ireland
Call: Coordination of European Smart Network actions (CSA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-05-01
End date: 2024-09-30
Duration (months): 29.0
Total project cost (EUR): 2874247.5
EU funding (EUR): 2874247.5
Participants: 19
Project status: CLOSED

The 6GStart project will facilitate the preparation activities of the European Smart Networks and Services Joint Undertaking (SNS JU) Initiative. This work will maintain the European momentum and leadership in 5G achieved through the 5G PPP and carry it forward to the new 6G SNS JU. It will bring the relevant players together to prepare the SNS JU by building on the work done to date in the 5G PPP. This approach will contribute significantly to Europe having a leading role in the definition, provision, and exploitation of 6G by 2030. The 6GStart project will ensure the inter-project collaboration structures and mechanisms will be established and in place by the time the first phase projects of the SNS JU start. As such, the 6GStart project will ensure the fast launch of the new SNS partnership and the availability of an efficient operational infrastructure for the inter-SNS-project coordination. The infrastructure for the 50+ ongoing 5G PPP projects will also be supported. The 6GStart Project will also orchestrate collaborations, and capture and promote the achievements of the new 6G SNS initiative and the ongoing 5G PPP by facilitating their activities in inter-project working groups and maintaining links to the NetworldEurope community and the 5G-IA membership. The 6GStart project will support the running of two editions of the EuCNC&6G Summit events in 2023 and 2024, as well as assisting the organisation of the Global 5G/6G events based on the inter-regional MoUs managed by the 5G IA, contributing to the strategy of promoting the European achievements in the wider ICT sector.

Keywords: sns,5g ppp,
Driving Transformation on Energy-efficient and circular Renovation through BIM (DTERBIM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Spain,Poland,United Kingdom,Greece,Germany,Italy,Belgium,Estonia
Call: BIM-based processes and digital twins for facilitating and optimising circular energy renovation (Built4People Partnership) (HORIZON-CL5-2024-D4-02, 2024)
Start date: 2025-10-01
End date: 2029-03-31
Duration (months): 42.0
Total project cost (EUR): 4639227.1
EU funding (EUR): 3830335.13
Participants: 18
Project status: SIGNED

DTERBIM envisions an innovative, interoperable and adaptable BIM-based collaborative design and project delivery methodology (the DTERBIM process) for efficiently managing construction and renovation projects and optimising resource management (materials, products, energy), time, and costs while embedding circularity principles from the outset. This new DTERBIM paradigm will be enabled by the DTERBIM Toolkit – a suite of easy-to-use, cost-effective BIM-based digital tools, AI-powered services, and Digital Twins – all integrated within the DTERBIM ecosystem and demonstrated to TRL8. An openBIM framework will underly DTERBIM to maximise the potential of BIM, Digital Twins, and circular renovation workflows by supporting seamless tool interaction, robust data exchange, and effective stakeholder collaboration. Serving as the central orchestrator, this framework will integrate commercial solutions and newly developed collaborative services to guide users through the entire building lifecycle—from design, construction, and operation to maintenance, deconstruction, and reuse—ensuring measurable improvements across all stages. DTERBIM’s impact will be validated in two virtual pilots — for technology validation in early stages of the project — and demonstrated in three representative real pilots: (1) a residential historical building in Valladolid [Spain], (2) an academic building in Warsaw [Poland] and (3) a kindergarten and elementary school building in Athens [Greece]. The result is a more inclusive, open, and technology-agnostic ecosystem that accelerates the digital transformation of the construction sector, enhances innovation acceptability, and supports the EU’s sustainability and digitalisation goals

Keywords: bim,digital twins,openbim,digital tools,ai powered services,interoperability framework
Change Hubs for Ecosystemic Social Solutions (CHESS)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Slovenia,Italy,Lithuania,Greece,Germany,United Kingdom
Call: Integration of social innovation actors in innovation ecosystems (HORIZON-EIE-2022-CONNECT-01, 2022)
Start date: 2023-01-16
End date: 2025-01-15
Duration (months): 24.0
Total project cost (EUR): 353410.0
EU funding (EUR): 353410.0
Participants: 7
Project status: CLOSED

It is now widely accepted in Europe that we need new approaches if we are to tackle the systemic and urgent societal challenges we face - traditional technological or business innovation alone is not sufficient. ‘Social’ must be part of the bigger innovation picture. With significant support from the European Commission, social innovation is currently well embedded in several policy agendas and funding streams. There are hundreds of social innovation centres, university research teams, accelerators and educational courses, labs, accelerators and incubators of all kinds, as well as a great number of toolkits presenting the various innovative approaches and methodologies that can be applied by students and established practitioners alike. Despite this success, the full potential of social innovation remains untapped. Different project reports and academic papers published in the past five years have pointed to several interconnected barriers hindering social innovation initiatives. Drawing specif Despite this success, the full potential of social innovation remains untapped. Different project reports and academic papers published in the past five years have pointed to several interconnected barriers hindering social innovation initiatives. Drawing specifically on the outcomes of three projects that members of this consortium have participated in – SI-DRIVE, SIC, and Labs for Social Innovation – we highlight the following challenges that merit critical attention: 1. Social innovation lacks access to finance, scaling models, and qualified personnel and is not applied enough. 2. Social innovators act in silos and are not integrated into the wider innovation ecosystems. 3. Social innovation toolkits are plentiful, but there is a lack of records about the tools’ effectiveness and pertinence. The CHESS project tackles the above challenges head-on by designing, implementing and testing a “Social Innovation Action manual” in four locally specific contexts.
Transformation for sustainable nutrient supply and management (trans4num)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Innovation actions
Countries involved: Germany,Netherlands,Denmark,Hungary,China,Switzerland,United Kingdom,Czechia,Romania
Call: EU-China international cooperation on nature-based solutions for nutrient management in agriculture (HORIZON-CL6-2022-ZEROPOLLUTION-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 5034396.25
EU funding (EUR): 4617123.38
Participants: 23
Project status: SIGNED

The project “transformation for sustainable nutrient supply and management” (trans4num) aspires to substantiate and broadly promote Nature-based solution (NBS) innovations for sustainable agriculture in Europe and China. In particular, trans4num will focus on nutrient management (bio-based nutrient sources, sustainable crop rotations, optimization of nutrient flows) and will 1) develop a differentiated understanding of NBS potentials for achieving sustainable agricultural practices, 2) study the complexities of applying NBS, 3) develop a dynamic and smart nutrient management tool to support regional decision making for optimum nutrient supply, and 4) assess the (net) impact of technological and social innovations as well as policies related to NBS. To realize its objectives, trans4num will use a social-ecological transformation (SET) framework tailored to study 20 NBS farm-level innovations in 7 regions with intensive farming systems. The project will implement the multi-actor approach to consider various societal concerns and interests related to NBS in agricultural nutrient management and to identify promising transformation pathways for social innovations conducive to a wider acceptance and adoption of NBS . In the course of four years, the project will bring together experience, expertise and knowledge across different fields, technologies and disciplines from 22 partners in Europe and China and apply a range of methods and formats to advance and foster NBS implementation prospects (e.g. farmer discussion groups, stakeholder panels, hackathons) The results of the project are expected to contribute to the European Green Deal, Farm to Fork, and Zero Pollution ambition strategies as well as China’s policy: the 14th Five-Year Planning for Green Agriculture Development strategy with their ambition to halt pollution and limit N/P emissions.

Keywords: intensive agriculture practices,nutrient flow optimisation,crop rotation,bio based fertilisers,socio ecological transformation,zero nutrient pollution
A Quantum Chemical Approach to Spins on Surfaces (SPINOCCHIO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Molecules and atoms with unpaired electrons exhibit a net magnetic moment and serve as the building blocks of molecular quantum devices for next-generation technologies. As the design principles for long-lived molecular magnets become clearer, the next challenge is assembling these units into spin lattices via surface deposition and addressing their magnetic behavior at the single-molecule level. Advancing molecular quantum technologies requires understanding the electronic structure and magnetic properties of these building blocks and their interactions with the environment; thus, it depends on quantum chemical calculations. However, our current theoretical toolkit for molecular magnetic materials is inadequate. Density functional theory fails to capture strong correlation, while wave function-based methods are computationally prohibitive for strongly-correlated materials. SPINOCCHIO aims to change this and advance our understanding of the static and dynamic behavior of spins on surfaces and surface spin arrays. These systems, which represent real molecular quantum devices comprising hundreds of atoms and multiple magnetic centers, pose a huge dilemma in quantum chemistry between system size and complexity. To overcome this challenge, we will develop a new quantum chemical approach that combines periodic quantum embedding with a coarse-grained treatment of strong correlation. Equipped with these new tools, we will investigate how the surface affects the magnetic behavior and spin relaxation of the magnetic adsorbate. Moreover, we will explore all light-induced phenomena key to the optical control of individual spins. This newly gained knowledge will guide the design of magnetically stable and optically addressable spins on surfaces, bringing molecular quantum technologies to fruition.

Keywords: quantum embedding theories,molecular magnets,electronic structure theory,equation of motion coupled cluster theory,quantum technologies,dynamic and non dynamic electron correlation