Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of the HYPOrheic zone on the transporter-transformer functions of River corridors. (HYPOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1482520.0
EU funding (EUR): 1482520.0
Participants: 1
Project status: SIGNED

Reactive substances transported in river corridors undergo several transformations having important implications for the fate of toxic chemicals and the health of fluvial ecosystems. Delivery of substances into the slow and geochemically-microbially rich hyporheic zone delays their downstream transport and promotes opportunities for biogeochemical reactions. The resulting delay and reactivity at larger scales are shaped by the ubiquitous heterogeneity of environmental porous media and the temporal fluctuations that typify river corridors which control transport and mixing limitations in the reactive regions of the hyporheic zone. However, the most widespread upscaling pictures neglect these fundamental aspects, assuming either a transient storage in a well-mixed hyporheic zone or pure advective transport along non-interacting hyporheic streamlines. The paradigm of oversimplification leads to severe shortcomings, such as limited transferability of findings and great uncertainty in large-scale predictions. HYPOR pursues a paradigm-shift: ground the upscaling of reactive-transport in river corridors on the mechanistic knowledge of the hyporheic dynamics. First, we will improve the understanding of heterogeneity and temporal fluctuations controls through comprehensive numerical investigations at small scales. Second, this will allow to quantify, on a physical basis, the stochasticity in the transport and mixing limitations of point-injections (Green functions) as they encounter reactive regions. The stochastic evolutions of Green functions will be the building block of a novel reactive-transport upscaled model to overcome current shortcomings. Yet, the hidden nature of the hyporheic zone leads to uncertainty. Third, HYPOR will exploit the link between small-scale uncertain properties and physics-based upscaling elements in a new uncertainty analysis framework that propagates uncertainty at small scales onto large-scale predictions, quantifying their reliability.

Keywords: hyporheic reactive transport upscale reactive transport heterogeneous porous media solute mixing in porous media uncertainty quantification
Bioinspired Electroactive Aeronautical multiscale LIVE-skin (BEALIVE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Greece,Poland,Germany,Italy,Switzerland
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 2495445.0
EU funding (EUR): 2495445.0
Participants: 8
Project status: SIGNED

Inspired from the highly efficient aerodynamics of birds, the versatility of the jelly-moon fringes, the manta ray and sharks, the multidisciplinary project BEALIVE introduces a new science and technology at the interface between aeronautics and bioengineering. The project creates a “live skin” composed of an innovative moving interface between an air-vehicle and the surrounding turbulence. Applied around a body, e.g. around an aircraft’s wing, this contributes to increase the aerodynamic performance and reduce noise far beyond all systems currently under study. The solid-fluid interface is composed of a large number of electroactive fringes made of an optimized combination of Carbon-Nano-Tubes and Graphene with high sensing and actuation capacity, able to deform and vibrate. This allows the skin to interact with the surrounding inhomogeneous turbulent flow. The interface between the solid and the fluid consists of the active fringes (shells) forming a porous-medium, modeled by poroelastic theory. The interaction and manipulation of the fluid-structure and fluid-fluid turbulent interfaces will create an optimal new medium with no distinction between the fluid and the solid structure. The “live skin” and the overall design will contain Big Data and rely on Artificial Intelligence and on a Controller that will define and optimise the dynamics of the system in real time and in large scale. The optimization will be based on data assimilation from Wind Tunnel experiments and from Hi-Fi CFDSM (Computational Fluid-Dynamics Structural Mechanics) using a triple solver coupling: structural modelling (SM), porous layer and turbulent flow. The design has as kernel a hierarchy of the interfaces, from micro to macroscale, between material-material, material-flow and flow-flow. Such enhanced levels of manipulation will allow drastic increases of aerodynamic performance and energy efficiency in all flight phases, beyond any currently foreseeable targets.

Keywords: smart materials,aerodynamics,wing design,carbon nanotubes,graphene,emissions and noise reduction,morphing,wind tunnel testing wt,cfd,structural mechanics,ai
Overcoming PAncreatic cancer immunotherapy resistance: developing PYRimidine receptor antagonists (PA-PYR-us)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The introduction of immunotherapy revolutionized cancer treatment, nevertheless, pancreatic cancer is still an omen of death with a dismal 5-year survival rate. Improvement of the current therapies for pancreatic cancer patients is thus an unmet medical need. The research we performed for the ERC CoG ImmunoFit identified novel metabolic pathways shaping the tumor microenvironment toward immunosuppression. Our latest publication in Nature Cancer characterized the CDA-UDP-P2Y6 axis as a major determinant of pancreatic cancer immune escape. With this PoC grant, we want to start the valorization of our findings, generating first-in-class P2Y6 biological blockers. Characterization of the metabolic crosstalk between cancer cells and the immune infiltrate, identified the UDP-elicited, P2Y6-dependent pathway as the most promising target to induce strong anti-tumor response and immunotherapy sensitization at minimal risk of side effects and generation of resistance. Evaluation of the current landscape of small molecules available for P2Y6 inhibition highlighted the urgent need for an out-of-the-box approach to generate a new class of molecules suitable to target this pyrimidine receptor in vivo. Here, we will take advantage of the specific know-how present in our host institute to generate (in collaboration with the VIB drug discovery center) VHH nanobody blockers. The feasibility of this ambitious project is ensured by (I) the strong results supporting the scientific rationale, (II) the compelling freedom-to-operate analysis, (III) the keen evaluation of the landscape of competitors as well as (IV) the presence of an outstanding experience, within our institution, on GPCR-targeting nanobody generation. With this application, we aim to start the generation and validation of P2Y6 biological blockers and file a “composition of matter” patent application to foster the further clinical development of our identified lead.
10 Angstrom CMOS exploration (10ACe)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Netherlands,Israel,France,Belgium,Germany,Austria,Egypt,Spain,United Kingdom
Call: General according to ECS-SRIA 2022 (IA) (HORIZON-KDT-JU-2023-1-IA, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 97951886.5
EU funding (EUR): 23912755.63
Participants: 32
Project status: SIGNED

The objective of the 10ÅCe pThe objective of the 10ÅCe project is to explore and realize solutions for the 10Å CMOS chip technology. Its consortium covers the entire value chain for manufacturing of the CMOS chips in the 10A node, that is, from chip design to lithography to process technology and finally chip metrology. Essential parts of hardware, software and processing technology are developed pushing the boundaries of semiconductor design and manufacture to enable the new node and keep Moore’s law alive. The 10ÅCe project is built based on the following four pillars. Lithography Equipment: ASML and expert EUV partners Zeiss, FastMicro, IOM, Plasma Matters, TNO, TU/e, University of Twente and VDL-ETG will: • Increase key performance indicators of the EUV tool, to enable smaller pitches and increase yield. • Increase sustainability of the EUV tool, both during production as well as increasing the times a module in an EUV tool can be refurbished. Chip design and mask optimization: Imec with the involvement of expert imaging , CAD and IP design partners ARM, ASML and Siemens will: • Assess the impact of the introduction of 3D mCFET on chip design: in terms of power, performance and area. • Development of new computational lithography solutions to print 10Å CFET structures, to improve imaging by next generation mask design. Process Technology: As the ultimate device for logic, the CFET architecture is proposed and Imec and expert partners Coventor, EVG, IBS, Intel, JSR, LAM, RECIF, TEL, Zeiss and Wooptix will: • Demonstrate a fully functional monolithic CFET (mCFET) • Increase sustainability of the chip manufacturing process, across the manufacturing process and including resist material development. Process characterization: Applied Materials and expert partners Thermofisher, Nova, KLA and Bruker will: • Explore and realize high throughput and sample density per wafer, for the analysis, characterization for 10Å 3D CFET devices, interconnect and materials

Keywords: chips,semiconductors,equipment,process technology,process metrology
Plasma Accelerator systems for Compact Research Infrastructures (PACRI)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Switzerland,United Kingdom,France,Sweden,Czechia,Spain,Germany,Portugal,Netherlands
Call: R&D for the next generation of scientific instrumentation, tools, methods, solutions for RI upgrade (HORIZON-INFRA-2024-TECH-01, 2024)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 9999255.0
EU funding (EUR): 9999253.0
Participants: 26
Project status: SIGNED

Plasma accelerators driven by advanced laser sources and/or compact electron linacs are key components for the next generation of green and sustainable research infrastructures. We propose a project on the development of "Plasma Accelerator systems for Compact Research Infrastructures" (PACRI), which will develop highly important and ground-breaking plasma accelerator technologies for Europe's future research infrastructures (RI). The specific objectives of PACRI are: - The development of high repetition rate plasma modules, as required for the EuPRAXIA ESFRI project, capable of extending its scientific scope from high average brightness radiation sources to high energy physics. - Improving the performance of normal conducting accelerator technology for X-band linacs, paving the way for high repetition rate operation (up to kHz) with a focus on efficiency and power consumption. - The development of key laser components required to scale up high power, high repetition rate laser technology as required by the EuPRAXIA and ELI ESFRI research infrastructures. The achievement of the PACRI objectives will enable the production of unique particle and photon beams with a wide range of applications in ultrafast science, high precision medical imaging, materials diagnostics, medical treatment and, in the longer term, the development of future compact colliders. These developments will be used for future resource-efficient upgrades of existing RIs at INFN, Elettra, CERN, CNR, CNRS, DESY, ELI, GSI/FAIR and UKRI. In addition, PACRI will support the implementation of ESFRI's EuPRAXIA distributed research facility by consolidating its sites and centres of excellence being developed under the ongoing EuPRAXIA_PP project. It will fund the development of some technical prototypes that are crucial for the implementation of the EuPRAXIA project and other European Research Infrastructures (e.g. enabling major upgrades to the ELI-Beamlines facility).

Keywords: particle accelerators,radiofrequency,plasma,laser,optics,electrons,klystron,accelerating structure,plasma lens
Microbial Isoprene Cycling Response in the Arctic (u-Arctic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Isoprene is a volatile organic compound (VOC) that accounts for more than a third of the total VOC emissions from ecosystems into the atmosphere. This VOC, primarily released by plants, is emitted at a rate of ~550 Tg/y and can significantly influence atmospheric chemistry and climate. Despite some knowledge of isoprene degradation in temperate regions, its role in Arctic ecosystems and the impact of global changes such as rising temperatures and drought remain poorly understood. The Microbial Isoprene Cycling Response in the Arctic (µ-Arctic) project, supervised by Professor Riikka Rinnan at the new Center of Excellence, Center for Volatile Interactions (VOLT) at the Department of Biology in the University of Copenhagen, aims to bridge these knowledge gaps. My objectives include isolating and characterizing active isoprene-degrading bacteria from Arctic plant phytobiomes, quantifying isoprene dynamics in Arctic mesocosms, and understanding the influence of elevated temperatures and drought on isoprene cycling rates. This research will leverage my expertise in targeted cultivation-dependent and independent methods, including Stable Isotope Probing (SIP) for DNA sequencing and metagenomics to provide more accurate insights into isoprene degradation. The outcomes of this study are critical for improving our understanding of Arctic isoprene cycling, which is becoming increasingly relevant due to climate change-induced temperature rises and their potential impact on atmospheric VOCs.

Keywords: environmental microbiology,microbial ecology,dna stable isotope probing,isoprene,volatile organic compounds voc,soluble di iron monooxygenases sdimos,metagenomics,mesocosms,global warming
Investigate the response of RBM20 and its pathogenic variants to mechanical stress and ECM remodelling (Hop-on-CARDIOREPAIR)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Czechia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 267941.25
EU funding (EUR): 267941.25
Participants: 2
Project status: CLOSED

Pathological extracellular matrix (ECM) remodelling underlies the onset and progression of most cardiac conditions. The biomechanical stress associated with ECM remodelling modifies the transcriptional and post-transcriptional landscape of cardiac cells. While the role of RNA homeostasis in the pathological heart is being appreciated, our understanding of the molecular processes governing this balance is limited. Post-transcriptional RNA modification facilitates quick adaptation to pathological conditions. Therefore, understanding how these events affect ECM remodelling has the potential to identify early therapeutic targets in treating cardiac diseases. RNA binding proteins (RBPs) have been recently shown to contribute to the onset and progression of these pathologies. Mutations in the cardiac-specific alternative splicing regulator RBM20 directly impact the splicing of the sarcomeric protein Titin and cause cardiac remodelling. Many pathogenic variants in RBM20 cause a hereditary form of cardiomyopathy and affect the nuclear import of RBM20 thereby causing splicing dysfunction and leading to the expression of the fetal isoform of Titin. Here we propose to leverage our experience with induced pluripotent stem cell (iPSC)-based models of cardiac diseases and ECM remodeling to challenge the hypothesis that RBM20 and its mutants display a specific mechanosensitive behavior in the heart. We hypothesize that, first, pathological ECM remodelling affects RBM20 subcellular localization thereby resulting in mis-splicing of RBM20 targets such as titin and further disrupting the cardiomyocyte function. Secondly, RBM20 variants affecting titin splicing and causing ECM remodelling may impact the subsecellular localization of other RBPs therefore further worsening the heart failure phenotype. We believe the research activities proposed will complement the aims of the CARDIOREPAIR project by providing novel insights into the molecular process of mechanosensitive splicing.

Keywords: ecm remodeling,cardiomyopathy,rna binding proteins,alternative splicing
Volatolomic approaches for improving success rates in assisted reproductive technology (ARTVOC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Estonia,Colombia,Malaysia,Romania,Spain
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 1759171.43
EU funding (EUR): 1495000.0
Participants: 8
Project status: SIGNED

Volatolomics has emerged as a new frontier in deciphering unreached matters related with health conditions. Volatolomics research is based on the study of the volatile compounds emitted by biological samples. It was demonstrated that the volatiles emitted though breath, skin, feces, urine or cells can provide useful information for the diagnosis of an important number of diseases, such as cancer, diabetes, or even neurodegenerative disorders. We have very recently demonstrated that the embryos do also emit volatiles during their development, while genetical disorders alter the pattern of the released volatiles. In the present project, we aim at assessing volatolomic techniques for the non-invasive assessment of embryos quality in order to select the most viable ones for transfer. The ultimate goal of this project is to achieve higher success rates in the in vitro fertilisation.

Keywords: volatile organic compounds gas chromatography mass spectrometry gc ms electronic nose embryo selection in vitro fertilisation
Extreme time and angular resolution in the optical with Cherenkov telescopes (MicroStars)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 2473531.0
EU funding (EUR): 2473531.0
Participants: 1
Project status: SIGNED

The universe in the visible wavelength remains largely unexplored in the sub-second time regime and sub-milliarcsecond scale, primarily due to instrumental limitations. Overcoming these impediments would bring a breakthrough in our knowledge of stellar physics, evolution and modelling by imaging the stars and their surroundings as well as unravel the history of the Solar System. MicroStars will demonstrate the viability of a cost-effective and novel solution to enhance the capabilities of Imaging Atmospheric Cherenkov Telescopes (IACTs) to perform ultra-fast optical measurements. Such an upgrade allows two novel applications of these telescopes in the visible range: their use as Stellar Intensity Interferometers and as high-time-resolution, fast, high-precision photometers. MicroStars will allow to expand the limiting time and angular resolution of current optical observatories by at least an order of magnitude. By upgrading the capabilities of next-generation IACTs, MicroStars has the potential of creating a host of scientific breakthroughs, answering fundamental questions regarding stellar physics, magnetic activity and modelling, exoplanet properties and the Solar System planetary formation. The interdisciplinary and field-transforming nature of MicroStars, merging astroparticle physics instrumentation with optical astronomy, will extend the scientific life of current IACT experiments, and greatly expand the scientific impact of the next generation: the Cherenkov Telescope Array. Bringing this proposal to life is only possible with an ambitious funding scheme, willing to finance the major equipment needed, and support a research team with the required multidisciplinary skills to expand the state of the art with novel instrumentation and methodologies.

Keywords: microarcsecond optical astronomy,imaging atmospheric cherenkov telescopes,planetary formation,stellar physics,kuiper belt objects