Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Educating the next generation of scientists in translation medicine: Focus on eye diseases (transMed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2019, 2019)
Start date: 2019-10-01
End date: 2021-11-30
Duration (months): 26.0
Total project cost (EUR): 60000.0
EU funding (EUR): 60000.0
Participants: 1
Project status: CLOSED

The Marie Sklodowska Curie actions pay particular attention to physical accessibility and inclusion and foresee financial support for the additional costs entailed by recruited or seconded researchers with disabilities.

Keywords: retinal dystrophy,low vision,accompanying person with technical skills
Go with the continuous flow: Asymmetric Synthesis of Bioactive Alkaloids by Multistep Continuous-Flow Processes (AsymmFlow)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

In the Realm of Chemistry, asymmetric synthesis has a prime importance as it allows creation of optically pure chemical entities. The synthesis of preferred enantiomer is highly desirable when seeking for specific biological activities owing to the importance of chirality. AsymmFlow delineates synthesis, characterization and application of novel asymmetric supported organocatalysts for enantioselective Pictet-Splengler cyclization in continuous flow/batch to produce tetrahydro-β-carboline (THβC) derivatives. The proposed immobilization strategy gives access to synthesize reusable, robust and stable catalytic systems for asymmetric continuous-flow processes. We aim to develop a sustainable and selective protocol which would give easy access to bioactive substituted-THβC moieties and thus fulfils the demand aiming at lowering their prices in global markets. In particular, the synthesis of the drug Tadalafil usually suffers for poor enantioselectivity, prolonged reaction times, and scale-up issues. It is expected that the development of an alternative protocol for the synthesis of Taladafil will solve those common synthetic challenges and thus, will be highly useful to bring down the market price of this drug all over the world.

Keywords: continuous flow,asymmetric organic synthesis,supported organocatalysts
Understanding epigenetic inheritance and the structures of non-amyloid prion condensates using deep mutagenesis scans (DEEPCONSTRUCT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Intrinsically disordered regions (IDRs) are pervasive in eukaryotic proteomes despite their poor evolutionary conservation. IDRs have recently gained considerable interest as drivers of the formation of biomolecular condensates, representing a novel fundamental principle of eukaryotic subcellular organization. However, a detailed mechanistic description of how intra and intermolecular interactions drive the formation, stability and physical properties of condensates is lacking. In this project, we will apply deep mutagenesis scans (DMS) to gain insight into sequence-function relationships of IDRs using the remarkable yeast [SMAUG+] non-amyloid prion as a model system. [SMAUG+] is induced through transient overexpression of the RNA binding protein Vts1, leading to the formation of gel-like condensates that are epigenetically inherited through cell divisions. In addition, [SMAUG+] condensates can act as protein-based infectious agents that transform naïve cells. We propose to massively mutagenize Vts1 IDRs and measure the individual and combinatorial effects of IDR mutations on [SMAUG+] formation and stability. This will allow us to gain insight into the mechanisms of condensate formation and prionogenic activity of [SMAUG+], and potentially uncover the structures of condensed [SMAUG+] through analysis of the genetic interactions (epistasis) between mutations. Finally, we will use automated microscopy of selected mutants to understand how mutations affect the inheritance of the prion. The insights obtained from this DMS analysis will be combined with information from previous genome-wide prion formation assays in order to build predictive models of non-amyloid prionogenic activity from protein sequence. The ultimate goal is to translate these models into metazoan proteomes, including human, in order to define novel non-amyloid prion candidates and begin to characterize their functions in non-genetic protein-based inheritance in normal development and in disease.

Keywords: prions,deep mutagenesis scans,intrinsically disordered regions
Water flow kinetics energy exploitation for mini/micro hydropower plants. (RIVER-POWER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

RIVER-POWER is a disruptive technology able to efficiently convert the water flow kinetics energy in electricity thanks to a turbine innovative design derived from the wind power technology. The new technology enlarges the hydropower potentialities, being able to exploit the zero-head water flows with mini-micro applications (nominal power < 1 MW) and thus allowing the exploitation of new electricity production sources. RIVER-POWER initiative objectives are: • producing the zero-head kinetics energy driven hydroelectric turbines with the following technical targets: production = 4200 kWh/kW; efficiency = 45%; electricity production cost < 7 c€/kWh; investment < 2.000 €/kW; trigger speed < 1 m/s; minimization of the environmental impact reducing the civil works; easy and cheap installation. • Fabricating and testing a integrated prototype (nominal power = 50 kW), to be proved in operational environment, in order to reach the TRL 9 at the end of the testing phase. • Industrializing the RIVER-POWER plant, protecting the intellectual right and launching the technology industrial production and commercialization. During the feasibility study, the Proposer EOL Power will assess in detail the technical, economical and financial viability of the initiative, quantifying the production costs and the market price, involving suppliers and potential end-users, developing a market strategy and a 5-years financial projections.

Keywords: mini and micro hydropower,renewable energy,water turbine,hydroelectric production
BIOphotonic SPECialists for Novel Raman Spectrometer Development (BIOSPEC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-29
End date: 2018-09-28
Duration (months): 12.0
Total project cost (EUR): 95250.0
EU funding (EUR): 95250.0
Participants: 1
Project status: CLOSED

Almost from its discovery there have been grand hopes for Raman spectroscopy to be an ubiquitous tool for chemical analysis. It has the potential to identify substances easily and distinctly from fingerprint-like spectra. This can be done with simple photonic architecture, allowing for potential portable and miniaturised form factors. Unfortunately the overwhelming fluorescence background common to all analytes obscures the weak Raman signal and thus makes this dream unrealised. Finally wavelength modulated Raman spectroscopy (WMRS) represents an innovative solution that delivers fast, fluorescence-free Raman spectra. WMRS has a wide range of potential applications in the healthcare industry from discriminating between cancerous and healthy tissue, to determining drug concentrations in biological liquids and identifying the presence of inflammation and infection. To realise this innovative development MSL require a ‘biophotonics engineer’ that has the correct specialised skills to carry out this development which are not currently available at MSL. MSL is looking to develop WMRS into a novel biophotonics tool capable of revolutionising Raman spectroscopic analysis. The aim of this project is to develop an innovation programme centred on WMRS for biological analysis. However, to realise this innovative development MSL require a ‘biophotonics engineer’ that has the correct specialised skills to carry out this development which are not currently available at MSL. This includes experience and knowledge across photonics development, biological analysis, Raman spectroscopy and programming. To meet this innovation opportunity MSL needs to overcome barriers to recruitment by widening its recruitment pool from UK to EU and increasing visibility. This project provides the framework to overcome these barriers and deliver the envisaged project results and impacts.

Keywords: biophotonics,biological analysis,raman spectroscopy,programming
Coordination of Automated Road Transport Deployment for Europe (CARTRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Germany,Italy,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Austria,Germany,Spain,Spain,Italy,Sweden,Belgium,Finland,Greece,Greece,France,France,France,France,France,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Coordination of activities in support of road automation (H2020-ART-2016-SingleStage-RTD, 2016)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 2999999.75
EU funding (EUR): 2999999.75
Participants: 40
Project status: CLOSED

Automated Road Transport (ART) is seen as one of the key technologies and major technological advancements influencing and shaping our future mobility and quality of life. The ART technology encompasses passenger cars, public transport vehicles, and urban and interurban freight transport and also extends to the road, IT and telecommunication infrastructure needed to guarantee safe and efficient operations of the vehicles. In this framework, CARTRE is accelerating development and deployment of automated road transport by increasing market and policy certainties. CARTRE supports the development of clearer and more consistent policies of EU Member States in collaboration with industry players ensuring that ART systems and services are compatible on a EU level and are deployed in a coherent way across Europe. CARTRE includes a joint stakeholder’s forum in order to coordinate and harmonise ART approaches at European and international level. CARTRE creates a solid knowledge base of all European activities, supports current activities and structures research outcomes by enablers and thematic areas. CARTRE involves more than 60 organisations to consolidate the current industry and policy fragmentation surrounding the development of ART.

Keywords: coordination,stakeholders,network,knowledgebase,guidance,data exchange,impact,roadmaps,research gaps,automated driving,vehicles,infrastructure,tri lateral cooperation
Laser cladding for the recovery of critical toolsdies (LASERFIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

"Car manufacturers have developed and incorporated new materials that guarantee mechanical properties to modern cars, such as greater impact resistance. The most remarkable ones are the Higher Strength Steels (HSS). As an example, Chrysler’s Gran Cherokee’s 29% weight was due to HSS parts and pieces in 2005, and currently latest models the ratio is 68% of HSS. HHSs are widely used in critical pieces like body-in-white structural parts and in skin pieces, produced by cold and hot mechanical stamping. The use of HSSs requires a greater deformation force into those pieces, and for that reason, stamping dies must be more robust and deterioration rates are much higher because of the increased effort, especially in the curved an complex areas of the pieces. In this extent, currently hegemonic tendencies in vehicle design include style lines in sharp edges instead of lines with radius. These shape complexity increases even more the complexity of stamping process and dies’ wear. Skin pieces are a paradigmatic example of these problems: highly relevant for success in sales of each model but a first line source of production cost increases. Thus, currently stamping dies suffer much greater wear rates than before, in part due to the use of new materials and in part due to the markets taste for complex shapes. Stamping Companies face the diatribe of dismissing the worn dies of try to repair them to reduce production costs on the risk of producing defective part or not achieving the required die strength. Stamping dies, throughout its useful life, are subjected to different processes which could be solved in the near future thanks to present project: restoration and repair of broken or damaged tools; renovation of damaged sharp edges by dents, for example in cutting tools; adjust mechanized errors during tool manufacturing; design changes. GNC LASER has developed LASERFIT technology and built a pilot production cell for the reparation of stamping dies.

Keywords: automotive,laser,cladding,recovery
Mobilising the European nano-biomedical ecosystem (NOBEL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Coordination and support actions
Countries involved: Ireland,Germany,Germany,Italy,Belgium,France,France,Portugal
Call: Mobilising the European nano-biomedical ecosystem (H2020-NMBP-CSA-2017, 2017)
Start date: 2017-10-01
End date: 2020-12-31
Duration (months): 39.0
Total project cost (EUR): 1999050.0
EU funding (EUR): 1999049.0
Participants: 9
Project status: CLOSED

In order to compete globally, Europe has to innovate and develop nanomedicines and medical technologies with high value and high technological content, well protected IP, and ensuring both a clinical need and commercial opportunities of all new innovations. Technically, this will be achieved by combining elements of key enabling technologies like nanotechnologies, photonics, robotics, advanced materials and information technologies to get smart medical devices and smart nanomedicines. However, the translation of the preclinical proof of concepts to the market via clinical validation, regulatory approval, and approval for reimbursement by the healthcare systems, requires a more integrated and streamlined ecosystem with less barriers between stakeholders and steps. Following their successful experience in the past 12 years of development in nanomedicine and medical technologies, ETPN and the seven other partners of NOBEL are merging their networks to set up a coherent, robust and unique ecosystem where information flow will improve awareness all along the value chain right up to the market access. It develops interactions, cooperation and implementation of complementary actions at local, regional, national, European and even international levels. The building of this ecosystem is based on two main pillars: a joint vision of the strategy for the future (roadmapping) and a high cohesion and interrelationship among the members of the ecosystem. One of the most significant and impactful outputs of this inclusive efficient ecosystem is the tangible acceleration of the development and industrialization of innovative SMEs in nanomedicine and medical technologies. This will impact the renaissance of EU economy by creating jobs and value in Europe. NOBEL will be unique in building the most efficient network of connections and synergies all along the value chain of Nanomedicine and healthcare technologies in Europe.

Keywords: nanomedicine,key enabling technologies,medical technologies,ecosystem,innovation,open innovation,translation,roadmapping,international cooperation,coordination,training,network,start ups
Multisensory Integration in Time and Space (MultisensoryIntegration)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-11
End date: 2018-03-10
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In natural environments, the brain is typically bombarded with multisensory information. Animals must continually evaluate which of these multimodal cues should be associated with a single physical object, and which are separate. For example, when a rabbit hears footsteps and sees a blur, is the blur responsible for the footsteps, or are there two separate sources of danger? Animals use two types of information to make this decision: spatial correlations (are the footsteps and blur localized together) and temporal correlations (does the blur move in sync with the footsteps). Humans constantly perform these same operations. We use lip movements to help identify the words spoken by a friend, a subconscious process which becomes painfully apparent when watching a poorly dubbed movie. This may explain why psychological conditions such as autistic spectrum disorder and schizophrenia often present with deficits in audiovisual integration. Despite the ethological and medical significance of multisensory integration, little is known about the underlying neural mechanisms. However, I believe the behavioral repertoire of the mouse, combined with new technological advances, provides an unprecedented opportunity to answer this fundamental research question. With recent developments in calcium imaging and optogenetic techniques, it is now possible to record and manipulate neural activity across the majority of mouse cortex. I will develop novel behavioral tasks for the mouse which require multisensory integration in space or time. By recording or perturbing cortical activity during these behaviors, I will determine the roles of individual neurons, neural populations, and cortical regions in multisensory integration. I will perform these experiments in the Cortical Processing Laboratory at University College London, led by Professors Kenneth Harris and Matteo Carandini.

Keywords: multisensory integration,cortex,vision,audition,behavior,two photon imaging,optogenetics
Optimization and clinical testing of Transcutaneous Implant Evacuation System. (TIES-TEST)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Belgium,Sweden,Norway
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 3558125.0
EU funding (EUR): 2490687.5
Participants: 3
Project status: SIGNED

Up to 700,000 citizens in Europe have undergone ostomy surgery; up to 60% of individuals with an ostomy will never undergo a reversal operation. Approximately 140,000 new stomas are performed every year in Europe and 120,000 in the USA. Patients with a conventional ileostomy have to continuously wear a stoma bag attached to the abdomen for collection of feces. Despite the availability of a large number of light weight, hygienic and discrete bags, many patients suffer from complications such as skin problems, leakage and odor, and for some the mere change of body image results in social isolation. At times, life for many stoma patients means difficult situations when the stoma controls their lives. The disruptive Transcutaneous Implant Evacuation System (TIES®) is a result of several years of research combined with the latest 3D manufacturing technology. It consists of a small tube made of pure titanium surrounded by a porous structure which allows smooth integration with the body tissues. The implant is built up layer by layer into one solid piece with 3D laser sinthering technology. This produces a unique structure with optimized surfaces and enables the use of a material that is clean and without impurities; together these factors promote reliable tissue ingrowth. A first of its kind, TIES will eliminate seepage, odor, noise, and the need for permanently wearing stoma appliance – offering a great improvement in quality of life in patients with ileostomy. The TIES emptying solution also provides a “non skin touch” way to drain the waste, eliminating the skin problems.

Keywords: ileostomy,ostomy,stoma,novel device for ostomy care,drainage bag,stoma bag,life without stoma bag,overcoming social isolation,transcutaneous implant evacuation system,ties