Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genetic determinants promoting resistance to BCR-loss in B-cell lymphomas (BCRlossToBWinner)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2023-11-25
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 2
Project status: SIGNED

Loss of B-Cell Receptor (BCR) in lymphoma B cells leads to attenuated PI3K/AKT signaling and altered Myc-dependent transcriptional output, resulting in a competitive disadvantage in BCR-deficient lymphoma cells. The acquisition of genetic events restoring signaling competence is sufficient to improve cellular fitness in BCR-deficient lymphomas. A fraction of Non-Hodgkin-B-cell lymphomas carry missense mutations in FOXO1, a transcription factor essential during B cell development, and a main target of the PI3K/AKT pathway, which relays survival signals downstream of the BCR. In preliminary studies, we found that cells with FOXO1 mutations rewire their signaling status showing a) activation of stress-activated protein kinases (SAPKs) and PI3K/AKT, b) altered responses to key upstream receptors, such as CD40 and BCR, and c) improved fitness. In this context, I propose to investigate whether FOXO1 mutations are able to provide resistance to BCR-loss in transformed B cells, by favoring the activation of PI3K/AKT, SAPK/JNK (and potentially other) signaling pathways. This hypothesis will be tested using mouse and human models that allow conditional deletion of the BCR in FOXO1 mutant B cells, determining whether expression of FOXO1 mutations is: a) sufficient to release normal B cells from BCR-dependency, and b) able to restore competitive fitness to BCR-deficient lymphomas. Moreover, combining CRISPR/Cas9 and chemical screenings, I propose to identify novel factors sustaining the growth of lymphoma cells that lost BCR expression. Overall, this research proposal will address relevant, yet unanswered questions in the biology of B cell lymphomas, providing a better understanding into the complexity of signaling competence in normal and transformed B cells, and identifying novel factors promoting independence from BCR signaling, to be exploited as therapeutic targets for the treatment of B cell lymphomas resistant to BCR-specific inhibitors.

Keywords: mechanisms of resistance in b cell lymphomas,b cell receptor,foxo1
Maintenance of species diversity and the stability of ecosystem functioning (BioFUNC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-06-15
End date: 2018-07-12
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Current rates of biodiversity loss threaten the delivery of a range ecosystem services critical to human welfare. To maintain ecosystem multifunctionality there is a broad consensus that biodiversity must be conserved or restored, but a key aspect of this, which is still poorly recognized, is that ecosystem services can only persist over space and time if ecological communities are stable (i.e. species within communities do not go locally extinct). However, the mechanistic connections between the maintenance of species diversity and the stability of multiple ecosystem functions have yet to be established. Such ecological knowledge is basic to understanding the social and economic benefits of management actions on biodiversity. BioFUNC aims to investigate the effects of the mechanisms maintaining species diversity (niche and fitness differences) on the stability of multiple ecosystem functions. To accomplish this we aim to take a multidisciplinary approach by combining recent advances in ecological theory with plant population models and observational and field experiments, along with structural equation modelling and meta-analytical techniques. Two lines of related research will be pursued: 1) an investigation of the effects of species traits on species coexistence in spatially and temporally variable environments, and 2) an investigation of the effects of species coexistence mechanisms on the stability of ecosystem functioning in space and time. BioFUNC is a collaborative project between IRNAS-CSIC (Spain, beneficiary) and IPS-University of Bern (Switzerland, partner), which foresees three key results. First, developing a toolbox for predicting when ecosystems services are transient or stable. Second, disentangling direct and indirect effects of climate, soil and species traits on biodiversity and ecosystem functioning. Third, predicting the sign and magnitude of a change in multiple ecosystem functions due to the loss of diversity or changes in species composition

Keywords: coexistence,complementarity effects,biodiversity,biomass,environmental variability,litter decomposition,niches,nutrient cycling,productivity,selection effects,traits
Community Energy for the uptake of RES in the electricity sector. Connecting long-term visions with short-term actions (COME RES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Spain,Germany,Spain,Italy,Italy,Germany,Germany,Belgium,Poland,Norway,Belgium,Latvia,Netherlands,Portugal
Call: Market Uptake support (H2020-LC-SC3-2020-RES-IA-CSA, 2020)
Start date: 2020-09-01
End date: 2023-02-28
Duration (months): 30.0
Total project cost (EUR): 2998847.5
EU funding (EUR): 2998847.5
Participants: 16
Project status: CLOSED

COME RES aims to facilitate the market uptake of RES in the electricity sector by supporting, with a set of specific activities, the implementation of the provisions for renewable energy communities (RECs) as defined in the new Renewable Energy Directive to be transposed in 2021. Taking a multi- and transdisciplinary approach, COME RES aids the development of RECs in nine European countries (BE, DE, IT, LV, NL, NO, PL, PT, SP). It covers different socio-technological systems including community PV, wind (onshore), storage and integrated solutions. The countries selected range from pioneers that have gained broad experience of community energy (CE) to countries that are just beginning to look at CE. COME RES analyses legal, socioeconomic, spatial and environmental characteristics, and the reasons for the slow deployment of RECs in selected target regions. Stakeholder desks consisting of the project partners and committed community, market and policy actors in each country take on the operational tasks. Both overall and specific objectives will be reached by i) analysing the potentials, barriers and drivers for RECs in the target regions, ii) carrying out stakeholder dialogues, iii) developing regional action plans and business-model proposals for target regions, iv) examining good/best practice cases that are transferable to specific local, regional and national contexts, v) initiating transfers of best practice solutions via policy labs supported by capacity development and training and vi) developing a renewable energy community platform. The consortium synchronises project activities with the transposition/implementation of the Clean Energy Package and its provisions for RECs in policy labs. Policy lessons with validity across Europe will be drawn and recommendations proposed. Over 85 stakeholders and market actors have provided letters of support expressing their commitment to support the project and implement its results.

Keywords: res market uptake,community energy,decentralised energy systems,enabling frameworks,stakeholder engagement,best practice transfer,business models,policy recommendations,low carbon transition
A molecular model of the microsporidian infection apparatus (PolTube)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Microsporidia are opportunistic fungal pathogens that infect organisms as evolutionarily divergent as protists and mammals. Due to their growing impact on the global food supply chain, the environment, and human health, these unusual spore-forming organisms have been classified as emerging pathogens of high priority. Intriguing cell biological features that are central to microsporidian infectivity and pose challenges to drug development are poorly understood due to a lack of structural information and the absence of genetic tools. As energy parasites, microsporidia survive with the smallest eukaryotic genome and without classical mitochondria through an obligate intracellular lifestyle. A fascinating infection mechanism, which involves a long, hollow protein structure, is essential for efficient host invasion. The microsporidia-specific infection apparatus consists of several structural proteins that form the polar tube, which is used to inject the entire cytoplasm from the infectious spore into the host cell. Here, we will use an innovative approach to provide the structural and mechanistic basis of the microsporidian infection mechanism by using cutting-edge structural biology techniques and novel developed in-vivo tools. By studying the endogenous polar-tube, we will identify new elements and provide an architectural model of the invasion organelle. Reconstitution and biochemical characterization of the major components of the polar tube, followed by high-resolution cryo-EM studies, will unravel the polar tube protein interaction network and provide near-atomic information to complement the architectural model. Together with the development of genetic methods to tag, visualize and manipulate components in-vivo, we will provide a comprehensive model of the infection process, give insights into the specialization and evolution of a fascinating and understudied organism and deliver ground-breaking tools to open new frontiers in microsporidian research.

Keywords: microsporidia,polar tube,cryo em
Enabling greasy mixed plastics recycling (EGREMPLARE)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Netherlands
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2021-01-01
End date: 2024-03-31
Duration (months): 39.0
Total project cost (EUR): 3030896.25
EU funding (EUR): 2121627.38
Participants: 1
Project status: SIGNED

Owing to their combination of unrivaled properties and low cost, plastics are the workhorse material of the modern economy. While delivering many benefits, the current plastics economy has drawbacks that are becoming more apparent by the day. The primary problem is the high material waste rate and poor closed-loop recycling in plastics manufacturing. Today, just 14% of plastics are used for recycling. To cope this problem, the European Commission has tried to implement increasingly stringent regulations, such as reducing landfilling or incineration, by increasing the taxes for waste disposal and promoting recycling. Nevertheless, the current inefficient recycling technologies make plastics recycled uncompetitive as raw material for many plastics converters. At TUSTI BV (Eindhoven, Netherlands) we have solved one of the great technical challenges for the recycling of greasy mixed plastics by developing (and patenting) an innovative washing process, based on bio-based cleaning liquids. These cleaning liquids entail many advantages, such as being bio-based and biodegradable (avoiding the creating of additional waste streams) and working at roomt T (saving 60% of energy consumtion vs current cleaning processes, and avoiding thermal degradation of the plastics). This innovative proprietary washing process uniquely positions TUSTI for the recycling of greasy mixed plastics. EGREMPLARE is an innovative, patented, recycling process that makes it possible to obtain high grade resins, applicable for packaging manufacturing and civil & construction engineering, from the currently disposed (mainly to landfills) greasy mixed plastics fraction.

Keywords: plastics recycling,plastic waste
Defining the mechanism of the dual spindle assembly and alignment in the mammalian zygote (DualSpindleAssembly)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

The first embryonic division after fertilization is essential for development of the organism and has to promote the union of the parental genomes. My host lab recently showed that in mammalian zygotes two bipolar spindles form, which first independently congress the maternal and paternal chromosomes and then must be aligned in parallel for a faithful division. The novel dual spindle assembly provided a likely rationale for erroneous divisions into more than two blastomeric nuclei observed in human fertility treatment. Indeed, preventing the alignment of the two spindles gives rise to multi-nucleated two-cell embryos also in mice. Due to its recent discovery and the difficulty of imaging in the light sensitive zygote, dual spindle assembly and function remains elusive. It is for example unclear what the contribution of cytoplasmic versus chromosomal microtubule (MT) nucleation is for forming two spindles and why spindle alignment is error-prone and variable between different mammals. Recent advances in microscopy in my host lab now enable me to address these questions. In my project, I will dissect the mechanism of dual spindle assembly and function by combining light sheet microscopy, computational image analysis, and molecular perturbation. To achieve this, I will perform 4D imaging of live mouse zygotes at high resolution that allows me to track individual nucleation sites as well as MT tips. This will allow me to generate the first spatial map of MT nucleation and assess what the contribution of the two MT populations for dual spindle assembly is. Moreover, I will test which MT nucleation pathway is essential for dual spindle assembly by molecular perturbations. Finally, I will check if errors in spindle alignment are the cause of parental genome loss, by identifying the key alignment factors and validate them in model organisms with different alignment fidelities. Thus, my studies will improve our understanding of cell division in mammals and human infertility.

Keywords: preimplantation embryo,microtubule,mitotic spindle formation,mitosis,chromosome segregation,light sheet microscopy
Zebrafish avatar as a real-time in vivo platform for personalized cancer therapeutics (ZEBRAONCOFISH)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2020-05-31
Duration (months): 33.0
Total project cost (EUR): 2004583.75
EU funding (EUR): 2004583.75
Participants: 1
Project status: CLOSED

The Zebrafish Lab is a biotechnological company leader in the development and commercialization of novel, tailor-made solutions based on in vivo zebrafish assays. Thanks to the extensive knowledge acquired by the R&D projects performed in the field by our team for many years and a close collaboration with Hospitals and Cancer Research Institutions, we have identified a remarkable opportunity in the ZEBRAONCOFISH project that will mean a 5-year after tax-R.O.I of 425% according to our estimations. The ultimate goal of the project presented as ZEBRAONCOFISH is to complete the technical roadmap required to bring to the healthcare market a novel real time in vivo platform for personalized cancer treatment based on the use of zebrafish “avatars” as personalized, living test tubes. Cancer is a leading cause of morbidity and mortality with approx. 35 million people affected by this disease and more than 8 million deaths per year. A major difficulty found in effective cancer treatment is the complexity of the biological mechanism underlying cancer onset and disease progression. This is because the genetic makeup and metabolic profile of each individual patient influence the effect of anticancer drugs. As such, different people respond differently to the same therapy. The solution we propose in the ZEBRAONCOFISH project is the use of zebrafish avatars as an in vivo platform to guide therapeutic decisions in actionable cancer patient-directed interventions. These avatars will be created by xenotransplantation (interspecies transplant) of human cancer cell lines/ tumor samples in zebrafish. The chance to carry out a dynamic display of the cancerous process in vivo will offer the unique opportunity to understand the subjacent cancer biology and design tailor-made treatments for each patient.

Keywords: personalized medicine,in vivo drug screening,cancer
Nineteenth-Century Digital Music: Sociopolitical and Proto-Digital Implications of the Street Crank Organ in Europe (NCDM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-24
End date: 2023-01-01
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

This interdisciplinary research project proposes a reframing of the crank organ and other mechanical instruments as proto-digital forms, offering a new perspective on the organ’s place in music history and opening up a new understanding of the emergence of digital music in terms of a continuity, rather than as something radically new causing a rupture with the analogue past. Due to be added to UNESCO’s list of Intangible Heritage, the crank organ is often viewed as a signifier for oldness, outdatedness, or the past; a closer look reveals strong commonalities with later digital music. Going beyond the technical level, I will confront these forms of music-making as part of a socioeconomic infrastructure utilising human and natural resources. The crank organ is the concrete shadow of digital music’s more obviously material past, and reintroducing into that history a hand-powered, wooden machine that operates on similar binary principles to electronically reproduced MIDI music can help re-anchor contemporary digital artefacts to their material roots. A massive increase in the accessibility of useable music composition tools with the advent of digital audio technology has correlated with a global division of labour which obscures the physical production of the machines. In terms of sustainability, the rematerializing of chains of production and consumption is an important project at this time. I will explore the social history of the organ as a window onto working-class, poor and itinerant urban musical life, alongside the technological history that sees the programming of these organs as a precursor to modern-day computer music, and demonstrate the intersections of these ideas. This fellowship will be carried out in Utrecht University under the supervision of Prof. Maaike Bleeker, with Dr. Floris Schuiling as a second supervisor, incorporating a 6-month secondment in the Speelklok Museum under the supervision of curator Marieke Lefeber-Morsman.

Keywords: music sound mechanical digital 19th century technology media performance playback robotics automata clockwork museum object crank,barrel organ grinder busking analogue entertainers programming
Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South (INVISIHIST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1499994.0
EU funding (EUR): 1499994.0
Participants: 1
Project status: SIGNED

Of the 193 member states of the United Nations (UN), over half belong to the grouping known as the Global South (also called the Developing World or Third World). Since its creation in 1945, Global South actors have sought to redefine political dynamics and change normative practices through the UN. Yet, histories of the organization are predominantly from the Western perspective. Challenging this view, this research will make a ground-breaking contribution to the field, providing a new genealogy of the UN within the contextual frame of global history in order to investigate how Global South actors shaped global order. It will bring together different perspectives of the UN from archives across the Global South, revealing currently invisible histories of the organization by examining how it was developed by Global South actors between 1945-1981. The project has 3 closely related objectives: 1. To examine how actors from the Global South changed the UN by developing its functions in the areas of decolonization, economic development and human rights; 2. To trace the ways in which Global South actors challenged the liberal world order as they pursued these rights; 3. To analyze why Global South agency at the UN led to the promotion of some issues and actors and excluded others and ask what the consequences were for order within the Global South. The project’s innovative contribution is in explaining the ways in which the UN has changed over time by placing an emphasis on the dynamic role of Global South actors. The research will elucidate histories of the ordering role of institutions at a moment when global governance is in crisis and the liberal world order appears to be fragmenting. Its primary impact will be in decolonizing the historiography by highlighting the historical agency of Global South actors, and transposing the importance of the organization in the longer history of the latter half of the twentieth century to provide a truly global history of the UN.

Keywords: united nations,global south,decolonization,global order