Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploitation of the SECRETory pathway for cancer therapy to address European research (SECRET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Austria,Germany,Israel,Italy,Spain,Germany,Norway,Greece,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 3915871.82
EU funding (EUR): 3915871.82
Participants: 12
Project status: SIGNED

Breast and colorectal cancer (BC and CRC) are the most frequent cancers accounting for 19% of all deaths from cancer in Europe. In case of triple-negative BC (TNBC) targeted therapies are not available and non-selective chemotherapy is the only treatment option. Targeted therapy has been approved for the treatment of advanced CRC, but response rates are low and treatment is limited to a subgroup of patients. Also, TNBC and CRC patients are prone to develop metastases and have a poor prognosis underpinning the need for new targeted and broadly applicable therapeutic strategies. Tumor cell secretion contributes to hallmarks of cancer e.g. hyperproliferation, evasion of growth suppression, loss of cell polarity, activation of cell motility, invasion and metastasis, shaping of the tumor microenvironment through altered presentation of proteins and the secretome, and resistance to cell death. Dysregulated secretion is thus a driver of cancer progression and therefore holds promise as a general therapeutic target for the treatment of cancers. However, strategies to exploit the secretory pathway for therapeutic and diagnostic purposes are still in their infancy due to the incomplete understanding of how this pathway is regulated by aberrant signaling. The overall research objective of SECRET is to drive the understanding of the mutual regulation of the secretory pathway and signaling in cancer, which will serve as a platform to identify and interrogate novel diagnostic and therapeutic strategies. SECRET comprises 11 beneficiaries and 7 partner organizations from 9 countries. Coordinated by the University of Stuttgart, SECRET will train 15 talented ESRs in the field of translational cancer systems cell biology and systems medicine towards a career in industry or academia through a highly interdisciplinary and intersectoral research training programme and inspire them to exploit the SECRETory pathway as a treasure trove to design novel therapeutic strategies against cancer.

Keywords: membrane trafficking,secretome,solid cancers,tumor microenvironment,cancer systems,medicine,biomarkers,targeted cancer therapy
Enabling Surgical Pocket REgeneration (ESPREE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-05-01
End date: 2023-04-30
Duration (months): 36.0
Total project cost (EUR): 2134093.75
EU funding (EUR): 1493865.0
Participants: 1
Project status: CLOSED

All medical devices implanted into the human body are perceived as foreign objects resulting in an attempt by the body to reject them through a process called foreign body reaction. This can result in either the failure of the medical device and/or significant clinical complications. Hylomorph has developed Hylomate®, the world’s first solution to protect all implantable medical devices in contact with soft tissues from foreign body reaction, acting as an “invisibility” cloak through complex interactions at the microscopic level with the surrounding tissue. Hylomate® is a platform technology that addresses all causes of severe complications connected to the implantation of synthetic materials. It ensures an all-round protection of the surgical pocket, preventing infection, hematoma, foreign body reaction and fibrotic encapsulation. Hylomate® increases the lifespan of implants and minimizes exposure to life-threatening risks. This results in (1) improved quality-of-life for patients, (2) better quality-of-care for healthcare providers and (3) reduced health economics burdens. The first application for Hylomate® will be in the field of cardiac rhythm management in combination with pacemakers, implantable cardioverter defibrillators, and cardiac resynchronization therapy devices. Other applications are currently under development in the field of breast reconstruction, aesthetics and nerve repair.

Keywords: implantable devices,microtopography,advanced healthcare materials,fibrosis,foreign body,reaction,cardiac rhythm management,biosynthesized cellulose,biomaterials,infection
Deconstructing complexity to reveal quantitative systems-level principles that enable multicellular systems to coordinately regulate genes over space and time (MultiCellSysBio)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

A key question in biology is how cells at different locations communicate through signalling molecules so that cells at the right place and time turn on the right genes. Such coordination is vital for many processes including the development of all embryos. A common set of strategies that cells from distinct organisms use to coordinate their gene expression has long been elusive. Finding it requires quantifying how two key factors, the spatial locations of cells and the genetic circuits that control the cells’ secretion of signalling molecules, each affects cells' gene expressions. This has been challenging because their effects are often intertwined in complex ways. To overcome this challenge, I will assemble budding yeasts into multicellular structures component-by-component in a bottom-up manner, from building genetic circuits to arranging cells in space. I will build genetic circuits whose motifs commonly occur in natural systems. The yeasts will use the genetic circuits to control secretion and sensing of three distinct signalling molecules for communication. Using adhesive proteins and light-inducible genes, I will assemble multiple yeast strains, each with a unique genetic circuit, into a single two- and three-dimensional multicellular structure. The structures will mimic various sizes, shapes, and arrangements of cells found in nature. I will then switch on the circuits in these cells to initiate communication between cells. Different amounts of signalling molecules will cause the cells to make different amounts of fluorescent proteins. By measuring the fluorescence of cells at different locations over time and then correlating them, I will infer the degree of cell-cell coordination. I will build mathematical models to guide the experiments. By finding which combinations of genetic circuits and spatial arrangements of cells enable cell-cell coordination of gene expressions, I will reveal design principles of multicellular systems that have been elusive.

Keywords: design principles of genetic circuits,quantitative biology,biophysics,network motifs,design principles of multicellular systems,collective behaviours,cell circuits
Deep Green Island Mode (DG Island Mode)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

15 million Europeans live on Europe’s 2,400 inhabited islands, at an average of approximately 1,500 households per island. As recognised by the European Commission, island energy is expensive, polluting, inefficient and dependent on external supply, with significant negative impacts on emissions, the competitiveness of businesses, and the economy. Assuming that just 65% of these islands’ electricity comes from diesel, we estimate that they produce approximately 17.5 million tonnes of CO2 every year. This is further increased when considering isolated coastal communities. Existing renewable alternatives are often unsuitable for these communities, such as wind and solar power, as the energy they generate is unpredictable and intermittent, making it difficult to rely on. They also have a large land footprint and high CAPEX costs. Tidal energy is also often unsuitable, as it requires fast tidal flows (over 2.5m/s) which only occur in a few specific hot spots around the World. The technology is also expensive, with both high CAPEX and OPEX costs. The Deep Green Island Mode (DG Island Mode) is a stand-alone tidal and ocean current energy converter for off-grid applications. The DG Island Mode is the concept of flying an underwater kite, that when steered in an 8-shaped trajectory, generates a speed of 8-10 times the speed of the actual current. This generates the following unique performance characteristics: - Generates cost effective electricity in tidal flows as low as 1.3 m/s - Generates up to 100kW, producing an estimated 0.35 GWh/year, enough to power 100 homes; - Can be located close to the shore; - Up to 15 times lighter per kW compared to other tidal energy solutions - Easy, low cost installation and maintenance (low CAPEX and OPEX costs); - Cost of energy 50% lower than diesel generators DG Island Mode offers cheap, clean, reliable electricity generation to island communities.
The Brexit effect in media coverage: how the intra-party democracy counters the rise of European populism (POSTBREXIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2022-06-30
Duration (months): 36.0
Total project cost (EUR): 319400.64
EU funding (EUR): 319400.64
Participants: 1
Project status: CLOSED

The main objective of the research is to conduct a pilot study in UK aimed at investigating the phenomenon of populism after the Brexit referendum, explaining how the intra-party democracy and deliberation can defuse its growth. In that respect, the research will consist of two distinct steps: 1) to analyse the media coverage after the Brexit referendum in order to identify populist issues; 2) to observe how party members elaborate these populist issues. As to the first step, analysis of media coverage, I will examine the interpretative frames that politicians, journalists and observers relied upon within the public debate. In particular, I will focus on the news about Brexit in a populist perspective and on its relevance after referendum in the public debate. As regards the second step, particular attention will be paid to the party members in order to examine how they elaborate 'populist' issues in a deliberative process. The importance of the study lies in the originality of the object under analysis. UK is an ideal case study for understanding the adaptation of populism in the European context and analyzing whether and how the intra-party democracy are able to counter the rise of phenomenon. The study has the potential to be expanded nationwide or into a comparative cross-country research. In fact, the research results will be used to analyse the next elections to European Parliament, understanding which policy “mechanisms” are able to contain populism impact on the European institutions.

Keywords: populism,intraparty democracy,primary elections,brexit,media coverage
Neuronal Information through Neuronal Interactions (NINI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1999375.0
EU funding (EUR): 1999375.0
Participants: 1
Project status: SIGNED

Our thoughts and actions result from the activity of functionally specialized neurons in the brain. We have learned a lot about how individual neurons encode sensory, cognitive and motor information. But we lack understanding of how this information comes about. The fundamental, yet rarely addresses, assumption is that this information results from neuronal interactions within local and large-scale brain networks. However, little is known about which specific interactions establish information coding. This is because neuronal interactions and information coding are largely studied in isolation in separate research fields. The key objective of this proposal is to close this gap, and to directly test which neuronal interactions establish information coding. We will employ a novel interdisciplinary approach that tightly integrates human and monkey electrophysiology and that combines several key advances established in our lab. First, we will perform directly comparable human M/EEG and monkey EEG recordings during the same decision-making task. We will employ a common analysis platform to identify local and large-scale interactions underlying information coding in both species. Second, we will characterize the circuit interactions underlying information predictive interactions in monkeys using simultaneous large-scale multi-area microelectrode and EEG recordings in the same behavioral task. We will combine these recordings with manipulative techniques to causally probe the circuit interactions underlying information coding. If successful, this work will constitute a paradigm shift in cognitive neuroscience by linking to largely disconnected fields: neuronal interactions and information coding. Identifying neuronal interactions that underlie neuronal information coding will establish a breakthrough for understanding the neural basis of our thoughts and actions.

Keywords: neuronal information,neuronal interactions,primate electrophysiology,oscillations
Architecture for Unified Regional and Open digital ecosystems for Smart Communities and wider Rural Areas Large scale application (AURORAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Italy,Spain,Spain,Austria,Spain,Italy,Austria,Belgium,Finland,Finland,Sweden,Norway,Norway,Norway,Greece,Slovakia,Portugal,Portugal,Portugal,Portugal,Portugal
Call: Boost rural economies through cross-sector digital service platforms (H2020-DT-2020-1, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 16265962.26
EU funding (EUR): 14569392.75
Participants: 30
Project status: SIGNED

Lower population and business density make it more challenging to develop private businesses and public services in rural areas, negatively impacting socio-economic indicators. Rural areas are key to solve climate change, food, biomass and energy challenges. Favourable climate for entrepreneurship is needed for better provision of jobs, basic services, including health and care, connectivity, smart transport, energy solutions and attractiveness as whole, overcoming digital divide between rural and urban areas. AURORAL focus on delivering a digital environment of interoperable services through platforms able to trigger dynamic rural ecosystems of innovation chains, applications and services. Thus, AURORAL contributes to increasing economic growth in rural areas and to tackle significant societal challenges. AURORAL digital environment is demonstrated by cost-efficient and flexible cross-domain applications through large-scale pilots in five European regions. AURORAL digital environment builds on an open, API-based, interoperable and federated IoT architecture and includes a reference implementation supporting flexible integration of heterogeneous services, bridging the interoperability gap of the smart object platforms and creating markets for services in rural areas. AURORAL digital environment addresses the integration of data and information across different platforms, establishment of an open market place, large-scale demonstration, multiplication of novel applications, the leverage of infrastructure and inclusion of public services. AURORAL pilots follow an evolutionary agile, well-delineated, and lean approach demonstrated in large-scale applications capable of meeting social and economic objectives critical to boost new rural services and business. AURORAL digital environment supports a vibrant ecosystem of developers, service providers and user communities and addresses barriers currently opposing the socio-economic development of rural areas.

Keywords: smart villages,rural development,interoperable data brokerage middleware,ecosystem,open api
METAclustered, SME oriented European Open Innovation Test Bed for the BUILDING envelope materials industrial sector using a harmonised and upgraded technical framework and living LABS (METABUILDING LABS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Spain,Italy,Spain,Ireland,Italy,Spain,Spain,Italy,Austria,Germany,Germany,Spain,Spain,Spain,Italy,Italy,Belgium,Türkiye,Hungary,Poland,Sweden,Türkiye,France,France,France,France,France,France,France,France,Luxembourg,United Kingdom
Call: Open Innovation Test Beds for materials for building envelopes (IA) (H2020-NMBP-TO-IND-2020-twostage, 2020)
Start date: 2021-01-01
End date: 2026-01-31
Duration (months): 61.0
Total project cost (EUR): 16324769.8
EU funding (EUR): 14944528.75
Participants: 47
Project status: SIGNED

To reach the COP21 goal of nearly-zero energy, zero emission buildings MBLabs Labs strives to unleash the innovation potential of the SMEs of the Construction sector by lowering the entry barriers to test innovative solutions in a network of testing facilities in RTOs and Living Labs in 13 countries, most EU member states (ES, FR, BE, IT, DE, TR, UK, LU, PL, SE, HU, AT, IE) allowing a direct feedback from the end-users during the final development stages. The MBLabs concept consists of 5 innovation pillars: 1) SME outreach by metaclustering & Open Innovation Digital Platform as cornerstones to engage and support SMEs in innovation and testing based on the networks of MBLabs’ 40 consortium partners, targeting over 180 clusters and building upon the sister H2020 METABUILDING project which reaches out to 9000 SME cluster members. 2) OITB Brokerage Business Model: the SEP will be a light brokerage structure in the form of an association - with the consortium partners as members - that serves as a business provider to entities running testing facilities and/or providing innovation services for building envelopes and finances itself through membership fees, adapted to the size and financial capacities of its members, market place revenues and a commission for the brokerage service. 3) Harmonised testing framework for building products development: consisting of guidelines for the characterization of smart/active systems, a detailed and validated energy model and LCAs to assure the application of EU regulatory practices. 4) O3 Building Envelope Testbench (standardized, replicable, affordable, Digital Twin enabled): first fully replicable, standardised, cost-effective Open Source/Open Data/Open Access Building Envelope Testbed enabling virtual testing and made available (co-funded) to some of the project partners. 5) Streamlined access to Living Labs & pilot matchmaking: with a single-entry point, an innovative matchmaking module and standardised internal procedures.

Keywords: building envelope technologies,materials,open innovation,digital platform,harmonized testing framework,open source,data,access testbed,single entry point,brokerage business model
Enhancing our Understanding of Earth’s Land Surface InteractiONs at Multiple Scales Utilising Earth Observation (ENviSION-EO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-02
End date: 2021-03-03
Duration (months): 24.0
Total project cost (EUR): 164653.2
EU funding (EUR): 164653.2
Participants: 1
Project status: CLOSED

Today, particularly so in the face of climate change and the need to meet global food and water security requirements, there is an urgent need for a better understanding of natural processes in the Earth System and of land surface interactions (LSIs). The recent rapid developments in Earth Observation (EO) technology (new satellites launched, drones) demonstrate the real need and the true potential of this technology in this direction. In this context, ENviSION-EO proposes the implementation of cutting-edge modelling interventions to the SimSphere Land Biosphere Model (LSM) towards developing a 2D LSM tool that will allow deriving for the first time spatio-temporal estimates of key parameters characterising LSIs. Furthermore, the action aims to unravel the potential of an EO-based modelling technique, so-called "triangle", in deriving estimates of key parameters characterising LSIs from EO data acquired from ESA's (Sentinel-3) and unmanned aerial vehicles (UAVs). Another aspect of ENviSION-EO lies in elucidating the potential of the "triangle" technique in downscaling existing global operational products of SSM provided today at a meso-scale-resolution using Sentinels-3 data. ENviSION-EO proposes to undertake ground-breaking research that will lead to the development of innovative modelling methodologies, LBM tools and EO-derived products. It is anticipated that these will greatly increase our capability to model LSIs at multiple, previously unattained, observation scales, and provide important information for both new research and practical applications. Furthermore, the multifaceted and novel developments of ENviSION-EO together with the capacity and track record of the host organisation and the supervisor in training researchers at the MSCA level ensure a holistic development of the applicant to a scientist with a unique set of skills and expertise in EO Modelling of LSI's globally. Dr. George P. Petropoulos is the applicant fellow.

Keywords: earth observation,remote sensing,land surface interactions,triangle method,simsphere,svat