Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transcranial brain stimulation as innovative therapy for chronic pediatric neuropsychiatric disorder – STIPED (STIPED)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Germany,France,France,Portugal,Portugal,Denmark
Call: New therapies for chronic diseases (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 6195231.25
EU funding (EUR): 6195231.25
Participants: 19
Project status: SIGNED

Due to lack of targeted interventions, compliance issues, insufficient effect sizes and a high non-responder rate to currently available interventions, there is an urgent need to develop innovative and new interventions for chronic paediatric neuropsychiatric disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Transcranial direct current stimulation (tDCS) has been shown to be an innovative, effective and safe alternative treatment approach for neuropsychiatric disorders in adults. Here, for the first time, the effect of tDCS on core neurocognitive and behavioral outcomes will be proven in children and adolescents. First, effect sizes and safety of standard tDCS in the clinical setting targeting core brain regions and disorder specific cognitive tasks will be established by three phase-IIa randomized, double blind, sham-controlled studies in ADHD and ASD. Second, the impact of brain development and age-dependent anatomical / functional features on effects of tDCS will be studied systematically using methods of modern neurophysiology, neuroimaging and electric current modeling. This involves an additional phase-I clinical trial. Third, mechanisms of tDCS on brain function will be studied, and biomarkers will be developed in order to predict individual response to standard and individualized stimulation protocols. Finally, the applicability of tDCS in children and adolescents will be improved by developing an innovative personalized home-based treatment option in combination with a telemental health service, which will be tested by a fifth, phase-IIa clinical trial. Throughout the entire project, ethical concerns of the target population will be addressed. This project opens a new avenue for the application of tDCS as an alternative treatment for a great number of chronic neuropsychiatric disorders in children and adolescents and will allow flexible integration of tDCS in the daily routine of families.

Keywords: attention deficit,hyperactivity disorder,autism spectrum disorders,transcranial direct current stimulation,biomarkers,modeling
Ironworking technology and social complexity of rural comunities during the Early Medieval Ages (Basquesmith)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The application of scientific techniques to analyse archaeological materials has greatly influenced modern archaeology, providing archaeologists with the tools to generate datasets, such as those associated with chronological dating and chemical compositions, from which more rigorous interpretations can be developed. The Basquesmith project aims to investigate ironworking production during Early Medieval (EM) times by applying microscopic techniques on an assemblage of materials excavated in rural settlements in the Basque Country (northern Spain), a region renowned for the superior quality of its iron products. Characterisation of the manufacture and repair methods used, the quality of the utensils produced, and the debris generated, will provide valuable insight into which production occurred at the sites. The originality lies in the artefacts themselves as well as the archaeometallurgical approach to investigate these assemblages. Common utensils such as ladles or keys made from iron, which are exceptionally rare in EM rural contexts, allow ironworking to be explored on rural implements from rural communities rather than prestige items from urban contexts. This will result in a truly utilitarian project combining history, archaeology and materials science to investigate a much neglected area for EM Spain. Basquesmith is highly committed to EU's strategy endorsed in the field of Cultural Heritage and is in an excellent position to carry out this research through the promotion of such an interdisciplinary approach. Moreover, Basquesmith integrates the applicant’s knowledge in material science with a top level research group (GIPyPAC) at the University of Basque Country. This network will not only encourage dissemination of the research within the academic literature and spotlight the cultural heritage of the Basque region, but it will also provide a framework which can be applied to the evaluation of technology in rural communities at other archaeological sites.

Keywords: material analysis,archaeometallurgy,ironworking,early medieval,peasantry,social agency,craft production,distribution systems,consumption patterns
Pathogenetic pathways in age-related neurodegenerations as novel therapeutic targets for Parkinson’s disease (PARNANT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2021-09-01
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Parkinson’s disease (PD) is the second most common neurodegenerative disorder (after Alzheimer's) associated with oxidative stress and aging, and affects an estimated 1% of people worldwide over 60 years of age. The pathogenetic triggers of neurodegenerations are largely unknown. Current therapeutic interventions only partially alleviate symptoms and do not restore normal neuronal function or prevent progressive neurodegenerations. Identifying novel molecular targets and searching for therapeutic agents that block neurodegeneration and promote neuronal restoration is a key challenge in the field. I and the Host have together identified 51 candidate genetic loci associated with age-related neurodegenerations in PD model and PD patients, respectively. These candidate genes are evolutionarily conserved in both vertebrate and invertebrate animals. I hypothesize that some of these genes, via an evolutionarily conserved signal transduction pathway, alleviate the oxidative stress in the dopaminergic neurons and protect them against degeneration. This project combines my (C. elegans genetics) and Host (cell-based PD models) expertise to identify new genetic pathways that mediate protection against neurodegenerations during oxidative stress and aging. I expect that achieved goals of the proposal will be important discovery that should lead to novel therapeutic targeting for Parkinson’s disease, and other neurodegenerative proteinopathies. My long-term goal is to become an independent scientist and establish lab to find novel therapeutic targets and strategies for the diseases associated with oxidative stress, including PD. Gained research experience together with improving my teaching, mentoring and management skills during this fellowship will help me to achieve my goals and transition myself into independence.

Keywords: c elegans,ips cell,neurodegeneration,genetics,stress
Disrupting Orthotics and Prosthetics Market with Open Digital Platform (OP-PLATFORM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Czechia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Custom-made orthotic and prosthetic (O&P) market grows rapidly as the global population ages and suffers from civilisation diseases. In the next 10 years the O&P industry will be disrupted by digital economy (automatisation, 3D printing and 3D scanning). Due to rising costs of O&P products and patients’ demand for improved comfort, function and aesthetics, every third O&P product will be 3D printed by 2027. However 3DP products need to be custom designed and that is costly, know-how & time demanding. With our proprietary technology and 25 years experience in the O&P market, Invent Medical set to become the Uber in orthotics and seize this market share with the Open Digital Platform by leveraging 3rd parties and automating & democratising the whole process in an ultra scalable and affordable way. We are offering benefits of digitalisation to medical facilities to improve people’s life worldwide as custom-made orthoses and prostheses are the only effective solution in a treatment of difficult injuries, deficiencies and civilisation diseases. The goal of Phase 1 of the project is to assess the feasibility of the Open Digital Platform business model. Activities will be focused on advanced Market analysis, IP research, Licensing of products, a Business Plan preparation and Pilot tests. Pilot testing of the platform will be conducted on two product lines to verify viability of the platform and cooperation with 3rd parties providing sales & support, manufacturing and computing. The project will have an impact on the global market due to global availability of a new generation of 3DP O&P products. Our disruptive business model complies with the EU strategy in healthcare to promote good health and healthy ageing by developing innovative solutions.

Keywords: medical,business model innovation,open digital platform,healthcare,digitalization
COntrolling network RAndom Lasers on chip (CORAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-03-01
End date: 2024-08-31
Duration (months): 54.0
Total project cost (EUR): 583232.76
EU funding (EUR): 583232.76
Participants: 2
Project status: SIGNED

The photonics industry in Europe is in rapid growth, lasers in particular have played a central role in several technological developments for many decades, from communications to medicine. As photonic devices shrink in both physical size and power consumption, integrated photonic devices will increasingly penetrate into consumer products such as smartphones and photonic sensors, for various applications from motion detection to navigation of autonomous vehicles. The European Industrial doctorate program CORAL will address the increasing need for educated professionals in this field, by the training of two young researchers in photonics technology and in particular in the relatively new field of random lasers, which is at the cross-roads between nanophotonics and neuromorphic applications. CORAL proposes a training programme between two world-class institutions, IBM and Imperial College London (ICL) each bringing in unique expertise and providing an appropriate balance of applied industrial research as well as in-depth understanding of the underlying physics. CORAL will bridge the entire value chain in III-V photonics integration based on both bonding and direct monolithic growth to establishing a simulation framework for networks of nanolasers. Both ESRs will gain experience with hands-on laser fabrication in the IBM cleanroom facilities, combined with various optical characterization routines at both IBM and ICL, and they will gain a deep understanding of laser physics from the advanced simulation at ICL. In addition to providing them with a scientific training meeting the needs of the European photonics industry, this will also push the emerging field of random laser networks towards a new level of maturity based on a III-V on silicon platform. Thereby, opening up for potential integration with silicon CMOS, and an entirely new range of applications.

Keywords: nanophotonic laser,nanowire laser,random laser,multiple light scattering
Gravitational-wave data mining (GWmining)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy,United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1499917.0
EU funding (EUR): 1499917.0
Participants: 2
Project status: SIGNED

Gravitational-wave astronomy is entering its large-statistics regime. Catalogs with thousands of gravitational-wave events will soon be available, providing a wealth of information on the most compact objects in the Universe --black holes and neutron stars. These new datasets need new tools to be exploited effectively in order to maximize their scientific impact. GWmining is an ambitious program to explore upcoming gravitational-wave catalogs with data-mining techniques. We will develop a complete framework to analyze gravitational-wave data in light of astrophysical predictions. Going beyond phenomenological models, we will train machine-learning algorithms directly on large banks of population-synthesis simulations and post-Newtonian integrations. The development of these astrophysical predictions requires new modeling strategies to accurately capture all the gravitational-wave observables, notably spins and eccentricities. Combined with a hierarchical Bayesian analysis, our neural network will deliver the most stringent measurements to date on elusive phenomena influencing the lives of massive stars. We will constrain phenomena such as binary common envelope, supernova kicks, stellar winds, tidal interactions, etc. Besides harnessing the catalog in its entirety, our complete framework will put us at the forefront to analyze outliers --golden events with favorable properties of one or more parameters. We will design a complete strategy to exploit the strongest signals to infer exquisite details of the relativistic dynamics of their sources. GWmining is a unique project strategically placed at the intersection of astronomy, data analysis, and relativity. As the large-statistics revolution of gravitational-wave astronomy unfolds, GWmining will pioneer the application of data-mining techniques in gravitational-wave population studies, setting the foundations of this booming field for decades.

Keywords: gravitational waves,black holes
Open innovation living labs for Positive Energy Neighbourhoods (oPEN Lab)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Innovation actions
Countries involved: Estonia,Spain,Estonia,Spain,Germany,Germany,Spain,Belgium,Switzerland,Belgium,Belgium,Belgium,Belgium,Belgium,Greece,Netherlands
Call: Building and renovating in an energy and resource efficient way (H2020-LC-GD-2020-7, 2020)
Start date: 2021-10-01
End date: 2026-03-31
Duration (months): 54.0
Total project cost (EUR): 21949812.5
EU funding (EUR): 19882855.259999998
Participants: 34
Project status: SIGNED

The aim of the oPEN Lab is to identify replicable, commercially viable solution packages enabling the achievement of positive energy neighbourhoods within existing urban contexts that are seamlessly integrated into the local energy system as an active micro-energy hub, and to test these technologies and package as an integrated solution at neighbourhood scale. Three open innovation living labs in the cities of Genk (BE), Pamplona (ES) and Tartu (EE) will test combinations of different close-to-market ready technologies and services and study their performance as a unique operating system. Focus is on demonstrating innovations in an integrated approach combining sustainable design tailored to the local context, seamless industrial renovation workflows, renewable energy generation combined with energy storage systems, urban service facilities and smart operation, life cycle thinking and circularity, and this across the whole value chain, targeting the whole life cycle of the building and its neighbourhood, in view of scaling up and wide replication. A user driven and participatory approach with the neighbourhood?s community will be rolled out for a holistic and positive energy vision for the neighbourhood, going beyond citizen awareness raising activities. oPEN Lab is a unique collaboration aligned with the Open Innovation quadruple helix model where a) industry (SMEs, large companies, start-ups and scale-ups in both construction and energy value chains), b) government (local public administration), c) academia/RTOs and d) civil participants (end users, NGOs) work together to co-create and drive structural changes that will result in high TRL levels, with great focus on exploitation of results and wide replication.

Keywords: building renovation,positive energy buildings,positive energy neighbourhoods,living lab,open innovation,community engagement,district energy systems,industrial renovation work flows
Functional genomics in Schizophyllum commune: leveraging the diversity in this hypervariable fungus to understand mushroom development (Mushroomics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Mushrooms are the sexual reproductive structures of basidiomycetes. Much remains to be learned about the molecular regulation of mushroom development. Only a few genes have been implicated in this process, but their exact function remains unknown. Schizophyllum commune is a model system for mushroom-forming fungi. It was recently shown that this species shows the highest intraspecies DNA variability in eukaryotes with 150 SNPs per 1000 base pairs, yet they can still reproduce sexually. This hypervariabity is also illustrated by variability in the response to environmental factors that initiate mushroom development and by the differences in morphology within this species. I propose a functional genomics approach to elucidate the molecular genetics of mushroom development. We have a collection of 100 S. commune strains sampled world-wide. I propose to leverage the extraordinary diversity among these strains. I will identify genes that explain differences in mushroom morphology and in responses to environmental stimuli such as light and CO2. The genes/alleles responsible for these phenotypes will by mapped by genome sequencing followed by bulk segregant analysis. Transcription factors (TFs) are expected to play an important role in regulation of mushroom development. Therefore I propose to systematically study TF function by generating a knock-down collection of all predicted 313 TFs. The phenotypes of the resulting strains will be analyzed and target genes of TFs will be identified by RNA-Seq and ChIP-Seq. The genes identified by these strategies will subsequently be analyzed to determine their function. My initial results demonstrate the feasibility of this approach. The availability of the strain collection, the available molecular toolbox, and my strong expertise both in genomics and molecular biology of mushroom development will enable me to take a huge step forward in our understanding of mushroom development.

Keywords: development,developmental genetics and pattern formation in fungi,eukaryotic microbiology
First ceramics of Atlantic Europe: manufacture and function (CERAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The arrival of farming had important consequences on many aspects of human society, from health to ideology. The study of this process therefore constitutes a key theme in prehistory and archaeology. One of the traits traditionally associated with the transition to farming in Europe is the introduction of pottery technology. For centuries, archaeologists have documented the appearance and dispersal of ceramic vessels across the European continent, using them as proxy for the shift to farming, domestication and sedentism, collectively known as the Neolithic transition. However, the role of pottery in the transition to farming is unclear. In other parts of world there are examples of both pre-farming pottery production and aceramic farming communities. With new research the basis that has underpinned centuries of Neolithic research is beginning to be questioned. Crucially, only by understanding the use and function of pottery can this technology be meaningfully linked to farming. By applying the latest chemical and molecular analysis, CERAM aims to reconstruct the use of pottery during this key transition focusing on the sequence of Atlantic Southern Europe. The host will train a ceramic specialist from Spain, with no prior experience of organic residue analysis, in the latest molecular and isotopic techniques providing the necessary skills for her to establish a similar facility in her home country where none currently exist. In turn, the fellow will bring specific expertise of ceramic technological analysis, not currently available at the host institution. Through her extensive prior experience and contacts, she will also provide an opportunity for the host to expand the application of organic residue analysis to a novel and under-researched context, i.e. Atlantic Southern Europe and consolidate long-term collaborations with a leading institute of coastal prehistory.

Keywords: biomolecular archaeology,neolithic pottery,organic residue analysis