Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Refactoring monoterpenoid indole alkaloid production in microbial cell factories (MIAMi)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Italy,France,France,Netherlands,Denmark,United Kingdom,Denmark
Call: Synthetic biology to expand diversity of nature's chemical production (RIA) (H2020-NMBP-BIO-2018-two-stage, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 6648301.25
EU funding (EUR): 6648301.25
Participants: 8
Project status: SIGNED

Plants produce some of the most potent human therapeutics and have been used for millennia to treat illnesses. The monoterpenoid indole alkaloids (MIAs) are plant secondary metabolites that show a remarkable structural diversity and pharmaceutically valuable biological activities with more than 2,000 MIAs derived from the common precursor strictosidine. However, because most MIA chemicals do not have their biosynthetic pathways elucidated and MIA-producing plants are not genetically trackable, MIAs are under-represented in recently introduced medicines. In the consortium for Refactoring of Monoterpenoid Indole Alkaloids in Microbial Cell Factories (MIAMi) our main objective is to develop sustainable microbial production of new human therapies for the benefit of the European biotech industry, human health, and the environment. To do so, MIAMi will i) develop a new approach for MIA biosynthetic pathway discovery in plants founded on supervised learning algorithms based on omics data sampled from > 20 MIA producing plants, ii) contribute to standardisation of bioengineering by development of SOPs for characterisation of > 100 DNA elements for control of gene expression, protein interactions, and sub-cellular localisation, iii) build a public parts repository and Bio-CAD for forward engineering of compartmentalised biosynthetic pathway designs in yeast, and iv) apply automated genome engineering to prototype > 1,000 new-to-nature MIA biosynthetic pathway designs in order to identify robust designs for scale-up microbial MIA production processes, and evaluate the environmental benefits and risks compared to existing value chains. The excellent, interdisciplinary and inter-sectorial consortium will showcase the use of the new approaches and standardised data inventory to produce both commercially available and new-to-market MIAs rauwolscine, tabersonine and alstonine in yeast, and finally test their bioactivity as new cancer and psychosis treatment drug leads.

Keywords: pathway discovery,therapeutic alkaloids,yeast,production,bioactivity
DANTE: Digital Alarm Network and Tracking Equipment for forest fire detection (DANTE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wildfires are a global phenomenon which can have a devastating impact on a country’s population, economy and environment. Although fire suppression costs are increasing every year, there is still a constant increment in the frequency and severity of wildfires. According to EM-DAT, 5.8 million people are affected worldwide every year by wildfires, with estimated economic costs of 45,000 million Euros. DANTE is the integrated low-cost solution for the early detection of wildfires that has received the awards Copernicus Masters 2017 and ESNC 2017. These are international competitions established on the initiative of ESA, GSA and the Copernicus Programme in which DANTE was rated as a business innovation to address EU challenges and an investment opportunity. DANTE is a prompt alarm system which features advanced methods to report and manage a fire within seconds of its starting. It provides the exact geo-referred coordinates of the fire source, tracks accurately the fire as it evolves and guides the firefighting extinguishing operations as a real-time navigator. The system is compatible with existing emergency control rooms and is managed remotely from either the control room or a smartphone with internet connectivity. DANTE has the potential to halve the yearly budget of public and private entities dedicated to wildfires extinction and detection (estimated to be of 10,600 million Euros extrapolating EM-DAT database). DANTE will be commercialised directly by AD TELECOM, including a network of official distributors to maximise the sales worldwide. This project will enhance the ambition of the company to grow and internationalise, targeting an inter-sectorial market in a B2B and B2B2B business model. First sales are expected in 2019, and the annual turnover is calculated to stay permanently above a million Euros after 2020. The company targets a total sale of 150,000 units within a lifetime of 12 years, which translates to a global turnover of 126 million Euros.

Keywords: wildfire,forest fire,fire detection,smart,rural,supervision,camera,image processing,control room,smart network,earth observation,drone,immediate roi,copernicus,esnc,astrosat
Brilliant Researchers Impact on Growth Health and Trust in Research (BRIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy,Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-06-01
End date: 2020-01-31
Duration (months): 20.0
Total project cost (EUR): 200000.0
EU funding (EUR): 200000.0
Participants: 7
Project status: CLOSED

The BRIGHT project aims at enhancing the visibility and the image of researchers among the general population in the Tuscany Region, simultaneously with all the European Researchers’ Night (ERN) initiatives. BRIGHT acronym means “Brilliant Researchers Impact on Growth Health and Trust in research”, it has been used in the previous editions of the ERN and is intended to underline the involvement of researchers in the enhancement of common people’s everyday life and their wellbeing. The project is planned for the years 2018 and 2019 and will last, each year, from Friday afternoon till Saturday at noon of the ERN scheduled date. In these “nights” are planned hundreds of entertaining and exciting activities that will involve the main Tuscan cities. The activities will be focused around the general theme of the pioneering activity of the researcher and will address some crucial issues such as migration (European Paths), food and climate, Cultural Heritage (European Year in 2018), The fascination of scientific discovery (What a Wonderful World), Public Health (Health 4 All) and New Technologies. Besides the organization of the nights’ events, BRIGHT will involve the population, and particularly young students of primary and secondary schools, all along the two years, through some citizen science’s project - that will have their public and crucial moments of presentation during the two ER Nights -, and through pre-events disseminated all along the period. This long period involvement is intended to create a strong tie among researchers (who will also attend a course on science communication), young students and general population in order to make researchers more “familiar” and to let people better understand how researchers work and live, and so why trust them.

Keywords: researchers,wareness,european year of culture heritage,research careers,health,food and climate,technologies,european paths
An ultrasonic non-destructive testing system for detection and quantification of early stage subsurface creep damage in the thermal power generation industry (CreepUT)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Lithuania,Greece,Croatia,United Kingdom,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 2854990.25
EU funding (EUR): 2387828.38
Participants: 5
Project status: CLOSED

Creep damage detection in pressurised steam line components is a major concern in the power generation industry. Currently, replica metallography is used to inspect these components. This method can only detect surface defects however evidence indicates that creep damage develops first inside the pipe wall and does not appear at the wall surface until the pipe is almost ready to fail. This results in catastrophic component failures which cost the industry more than €500,000 in lost revenue per day out of operation. To combat this, we will commercialise the CreepUT system, which employs a proprietary Ultrasonic (UT) technique that enables the early detection of sub-surface creep damage. We are an industrially driven consortium with significant expertise in field inspection services and NDT product development. We have already tested and validated the capabilities of CreepUT in relevant environment but require about €2.5 million to evolve our system from TRL-6 to TRL-9 and speed-up the delivery of the CreepUT product into the market place. We plan to refine the hardware electronics and make our system more ergonomic to be used by technicians. A major part of the project is focused on validating the performance of the system in an industrial power plant; in this effort, we are supported by PPC, one of Greece’s top energy companies. Activities will target towards certifying the CreepUT product, fine tuning our marketing plan, approaching new customers and setting-up our customer services department. We will penetrate the fossil and nuclear power generation industry in UK, Greece, France, Saudi Arabia, India and China. We calculate total revenues of €14.59million by 2024, operating at a profit of €2.05 million and creating 42 new jobs. The power generation industry will benefit from reduced outage periods; hence the power plants will operate safer and for longer saving the industry about €32 million per year.

Keywords: ultrasonic,non destructive testing ndt,type iv creep damage detection,creep strength enhanced ferritic steel components,fossil fuelled and nuclear power plants
CAScading Climate risks: towards ADaptive and resilient European Societies (CASCADES)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Italy,Germany,Germany,Switzerland,Finland,Sweden,Poland,Netherlands,United Kingdom,United Kingdom
Call: Climate change impacts in Europe (H2020-LC-CLA-2018-2, 2018)
Start date: 2019-09-01
End date: 2023-12-31
Duration (months): 52.0
Total project cost (EUR): 6944384.75
EU funding (EUR): 6944384.75
Participants: 12
Project status: SIGNED

Climate change amplifies existing risks and vulnerabilities in a globalised world. New risks are also emerging from complex cross-sectoral and multi-dimensional interactions that aggregate gradually, and sometimes emerge abruptly. Recent examples of links between crop damage in Russia, international food prices and political instability in North Africa, as well as impact chains from drought, migration, civil unrest and war in the Middle East, demonstrate how climate-induced risks outside Europe can cascade and threaten Europe. CASCADES strives to understand the conditions under which climate risks propagate beyond their geographical and temporal location in ways that may affect European stability and cohesion. It does so via a broad 360° risk assessment and deeper thematic analyses of trade, value chain, financial and political connections between Europe and the rest of the world. CASCADES’ ambition is to identify the policy leverage points that can help the EU to adapt and respond to such cascading climate risks. CASCADES integrates a wide range of established and innovative methodologies – many of which have not been seriously applied to adaptation questions before – ranging from biophysical climate impact modelling, economic modelling of trade and financial networks, and data integration methods, to qualitative approaches including hotspot case study analysis original social science research and serious games. CASCADES combines leading expertise in climate change impacts, vulnerability and adaptation, international trade and commodity flows, foreign policy and security, and finance and business, with deep knowledge and proven experience of co-creating with – and influencing – stakeholders from private sectors, public policy and civil society. CASCADES will provide knowledge and tools to support policy and decision-making processes, thus helping Europe to strategically navigate a sustainable and resilient path through a rapidly changing, interconnected world.

Keywords: adaptation,business,cascading risks,climate impacts,cohesive policies,finance,foreign policy and security,institutions,modelling,stakeholder engagement,supply and value chains,resilience,trade
Multi-level SiC Module for Aircraft applications (MuSiCA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom,United Kingdom
Call: Power Semiconductor Device module using Silicon Carbide devices for a relatively high-frequency, circa 100kW aircraft motor drive applications (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-09-01
End date: 2022-11-30
Duration (months): 27.0
Total project cost (EUR): 776888.0
EU funding (EUR): 619525.0
Participants: 2
Project status: CLOSED

MuSiCA will design and supply a power electronic module and gate driver using silicon carbide devices for a relatively high frequency 100kW aircraft motor drive application. The power converter topology has been chosen and is provided as an input to the project. The main objective is to package silicon carbide devices in a manufacture-able and reliable power module package to enable silicon carbide technology to meet its full potential in terms of competitiveness against current solutions. The power module package will be integrated with the gate driver developed in the project. The hardware will be produced during the project and tested on an existing Clean Sky 2 funded motor drive test bed. The output of the project will be a demonstration of the manufactured hardware and evidence of its manufacturability, reliability and low weight and volume, and potential to reduce CO2, NOx and Noise emissions. The target application is European Aerospace but the solutions developed will be applicable to other applications such as automotive, rail and renewable energy, where high reliability and manufacturability is desirable. The key objectives of MuSiCA are to: Increase manufacturability, Increase long term in-service reliability, Increase modularity and scalability, Integration with Clean Sky test bed, Maximise the performance of silicon carbide power semiconductor devices, Enable the demonstration of the complete power converter. The power electronics module developed in MuSiCA will support the Clean Sky ambitions. It is expected that MuSiCA will directly address the ITD Systems and in particular will feed into the WP5 and WP 100.1: “Power Electronics and Electrical Drives” The CfP supports the activities within the Systems Integrated Technology Demonstrators by delivering an innovative multi-level power electronics module which can be used as a functional building block for the construction of converters for a variety of uses in on-board energy conversion systems.

Keywords: multi level sic module,planar,compact power module,integrated gate driver,silver sintered interconnections,wire bond free power module
Molecular dIffusion of organiCs in secondaRy Organic aeroSols and impaCts On Particle chEmistry (MICROSCOPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-01
End date: 2023-07-31
Duration (months): 36.0
Total project cost (EUR): 247606.08
EU funding (EUR): 247606.08
Participants: 2
Project status: SIGNED

Molecular diffusion of organics within secondary organic aerosol (SOA), a main class of tropospheric particles, controls predictions of particle mass, size, mixing state, and cloud formation properties, thus SOA’s role for air quality, atmospheric chemistry and climate. Despite that, measurements of diffusion coefficients of organics in SOA at low, tropospheric relevant temperatures (T) are largely missing. The objectives of MICROSCOPE are to directly measure diffusion coefficients of organic molecules in SOA particles at T < 290 K, improve parametrizations used to estimate diffusion, test predictions of diffusivity in atmospheric models and assess the impacts on particle chemistry, by the combination of development of innovative instrumentation, experimental and modelling work. Measuring diffusion coefficients as a function of water activity (aw) and temperature, will be achieved by developing a new flow cell with simultaneous and in-situ T and aw-control for rectangular area fluorescence recovery after photobleaching measurements. The chemical composition of the SOA samples will be determined using high-resolution mass spectrometry, with the goal to improve existing parametrizations used to estimate the diffusion of organics in SOA and derive new ones that directly relate chemical composition to diffusion coefficients. The new T and aw-dependent parametrization will be used along with model output to verify if tropospheric mixing times of organics in SOA particles are < 1 h. Finally, the impact of diffusion of organics on SOA particle reactivity and chemistry will be determined through measuring the degradation rates of peroxides within SOA particles, using aerosol flow tube and X-ray microscopy experiments. By combining the expertise of two research groups in North America and Europe, state-of-the-art laboratory facilities, and small and large-scale instrumentation, both the scientific as well as the training goals of this action will be reached.

Keywords: secondary organic aerosol particles,diffusion coefficient,diffusion,aerosol particles,aerosol processes,mass transport,x ray microscopy,rfrap,soa chemistry,microscopy
Dissecting tissue-resident lymphocyte homeostasis in humans (RESIDE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1498972.0
EU funding (EUR): 1498972.0
Participants: 1
Project status: SIGNED

Natural killer (NK) cells contribute to tumor and antiviral immunity, regulate immune homeostasis, and impact on pregnancy success. These functions are in many instances performed in peripheral organs. Recent pioneering research in mouse models has revealed the existence and self-maintenance of tissue-resident (TR) NK cells. Although similar mechanisms are assumed to occur in humans, this has never been formally demonstrated and with our diverse infection history and active microbiota the human setting is considerably more complex. Me and my group have recently identified and characterized presumed TR NK cells in human liver and uterus. Here, we seek to challenge the prevailing concept from the mouse of how TR is formed, regulated, and maintained by taking advantage of world-unique surgical procedures for addressing lymphocyte tissue-residency, such as uterus transplantation and a novel liver surgery creating a human parabiosis situation, combined with single-cell technologies. In these settings, we will determine the detailed characteristics of subsets of NK cells permanently residing in tissues. With the different time windows as well as tissue sites presented by the clinical procedures, we will also assess kinetics of NK cell tissue repopulation. Furthermore, we aim to provide mechanistic insight into NK cell recirculation patterns by studying tissue-draining lymph fluid. Finally, we will study functional regulation of NK cell tissue-residency based on data from targeted single-cell RNAseq across multiple human tissues. The relevance of suspected and novel factors in regulating TR NK cells will be studied in a 3D microvasculature model combined with siRNA-based silencing of candidate genes. TR immune cells are poised to instantly deliver immune responses upon tumor and pathogen challenges while also being drivers of inflammation and autoimmunity in peripheral organs. Thus, this proposal has the potential to provide ground-breaking new knowledge in these areas.

Keywords: natural killer cells,tissue immunology,human immunology,tissue residency