Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DLIVER - Digital B2B marketplace for fast and efficient parcel delivery (DLIVER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For short-distance delivery of goods, only 40% of vehicle cargo capacity is used. The result is a staggering €68Bn in lost revenues for goods providers and goods transport companies annually. This is because most goods transportation companies still use basic spreadsheets that are unable to match in real-time the supply of vehicles with the demand for transport services. The negative impacts are two-fold: 1) high fuel-costs and subsequent high CO2 emissions for goods transport companies and; 2) high prices for deliveries for the sender. DLIVER is the World’s first digital B2B marketplace that matches supply of carrier vans’ capacity with demand for parcel delivery services – in a convenient, transparent and cost-efficient way. Thanks to our proprietary Machine Learning algorithms, DLIVER overcomes the known problems and has already been shown to increase the cargo capacity used by carrier vans significantly. It will disrupt the short-distance goods transport market by providing an effective, convenient and affordable solution. The aim of this project is to bring our DLIVER solution to European and international markets. Our current private Beta version is being used by +10 daily users in the Copenhagen metropolitan area, providing confirmation that our solution can increase the number of daily deliveries per driver by +12% and reduced fuel consumption by +10% per average daily turnover per vehicle. The objective of this Phase 1 project is to lay the foundation for scaling up our innovation to reach TRL9 and launch in Europe in 2021, build a profitable business and reduce the cost and carbon footprint of millions of deliveries. The business opportunity is significant. Our Total Addressable Market is €21.4Bn and will reach €27.1Bn by 2025. Through our scalable digital marketplace business model, we expect to capture a market share of 0.43% (of Serviceable Available Market), a turnover of €115.4M, EBITDA of €95.7M and additional employment of 152 people by 2025.

Keywords: digitalization of parcel delivery,cargo capacity optimization,express parcels,digital marketplace,efficiency improvements
Attracting and Encouraging Triple I Talent Mobility (Athenea3I)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2017-10-01
End date: 2023-03-31
Duration (months): 66.0
Total project cost (EUR): 4248000.0
EU funding (EUR): 2124000.0
Participants: 1
Project status: CLOSED

Athenea3I is an innovative regional wake-up call focused on attracting highly talented researchers to Granada (Andalusia region, Spain) in order to benefit their research career with International, Interdisciplinary and Intersectorial opportunities. This innovative fellowship programme offers the experienced researchers an outstanding opportunity to develop new skills and competences, enriched with a personalized and pioneering career mentoring plan. It also includes research periods at some of the most distinguished outstanding institutions around the world, and optional secondments in regional, national and international companies. The high-talented human capital hired by the University of Granada, as beneficiary institution, will perform as active “magnets” in relation not only to academy, but to industry and business, establishing bridges for transfer of knowledge, exploitation of the results, and future research collaborations. Athenea3I commitment pivots on the applicability of the research outputs by making Science for Society: reinforcing not only the innovation aspect but also the open data access and the public engagement. It has on target the social challenges of Andalucia2020, shooting up their results to palliate some socio-economic problems of the region and, consequently, to get towards the Europe2020 targets.

Keywords: triple i,talent mobility,networking,er mentoring,research carreer development,innovation,regional weak up call
A revolutionary dyeing process to help the textile industry reduce its environmental impact (Colorifix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2020-01-01
End date: 2022-06-30
Duration (months): 30.0
Total project cost (EUR): 3525087.5
EU funding (EUR): 2467561.25
Participants: 1
Project status: CLOSED

The fashion industry is the second largest polluter in the world. Dyeing processes cause major environmental damage because of the toxic chemicals in pigments. They also use up to 200 litres of water to colour just 1kg of fabric. Colorifix solves these problems by introducing advanced synthetic biology to textile dyeing. We engineer the DNA responsible for colour in Nature into self-replicating microbes. The resulting engineered microbes produce, transfer and fix colorants in a unique and integrated process. Microbes are grown on an industrial scale using renewable feedstocks such as molasses. The process is biologically safe, uses zero toxic chemicals, reduces water consumption by 90% and cuts energy use by at least 20%. Colorifix' target markets are very large and include sustainable high street fashion, luxury apparel, sportswear, and automotive textiles, amounting to global trade of €370 billion p.a. The provision of textile dyeing services in these markets is worth c. €10 billion p.a, and growing at a rate of c. 9% p.a. The technology is highly scalable and low-cost compared to rival methods. This is because it avoids the cost of extracting and purifying pigments, and because the process is compatible with standard dye machines. The company will transform textile dyeing from one of the most environmentally harmful industries to an eco-friendly, sustainable process. Commercial interest in Colorifix is extremely high. The company is already engaged in lab-scale trials with the largest global fashion brands and textile producers, including Stella McCartney, Filippa K, a global fibre producer and one of the world's largest automotive textiles producers. The Phase 2 project will provide the capital needed to construct and operate a pilot production facility, enabling testing for customers on pre-production volumes, and preparing full commercial scale-up of the technology in textile production around the world.

Keywords: fashion technology,bioeconomy,circular economy,textile dyeing,pigments,textile finishing
Is environmental justice necessary for human well-being? Comparative analysis of certification schemes, inclusive business, and solidarity economy strategies (COMPASS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1499250.0
EU funding (EUR): 1499250.0
Participants: 1
Project status: SIGNED

Unprecedented concentration in agri-food value chains is reinforcing global inequality. Waves of land grabbing threaten the livelihoods of millions. Reshaping the effects of agricultural investment, land use, and trade on human well-being is thus an urgent challenge. Certification schemes (CS) such as “Fairtrade” have become a common strategy to meet this challenge. However, accumulating evidence shows that many CS have limited effects on well-being. Inclusive business (IB) and solidarity economy (SE) strategies are emerging alternatives. Inclusiveness and solidarity are widely believed to enhance well-being, but evidence and theories disprove this common belief. Environmental justice may be a necessary condition to understand and reshape the effects of CS, IB, and SE on well-being. However, lack of reliable data and comparative analyses limits understanding of these links. COMPASS will tackle these challenges. This project aims to demonstrate how environmental justice influences the effects of CS, IB, and SE strategies on human well-being. COMPASS is organized in four work packages (WPs) and focuses on the cocoa and coffee sectors of Peru and Switzerland. WP1 surveys organizations (n=120) to compare their instruments used in CS, IB, and SE strategies. WP2 surveys households (n=840) and uses set-theoretic and process-tracing methodology to explain the effects of CS, IB, and SE on well-being. WP3 identifies the rules that organizations (n=18) create to regulate land use, investment and trade, assesses their environmental justice, and explains how they influence well-being. WP4 generates context-sensitive generalizations of these effects, and it tests and advances pertinent theories. COMPASS breaks new ground by systematically comparing CS, IB, and SE strategies and their effects on human well-being. It develops a new strand of environmental justice research on private-sector strategies and it tests the transformative potential of environmental justice.
QSEIF: The new pathogen, DNA and immunological testing platform (QSEIF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 1690250.0
EU funding (EUR): 1183175.0
Participants: 1
Project status: CLOSED

iMiCROQ aims to bring to the market the first integrated platform for pathogen, immumological and PCR testing specially designed to cover the whole needs at farm level, internal control laboratories, food processors and point-of-care infectious disease testing. Thanks to its affordability, QSEIF will allow from SMEs to large companies to improve their biosafety and internal microbiology control to fulfil their requirements from ISO 22000, BRC or IFS certifications, while reducing the needs in laboratory space, the investment, the test cost and man-hour involvement thanks to higher automation. Another important breakthrough in the immunological sector is that QSEIF provides 1-2 orders of magnitude lower limit of detection, less time and better dynamic range than current reference test ELISA. We envision three important applications of this disruptive platform in the areas of: (1) Food Safety; (2) Vaccination Control; (3) Immunoassays for human and animal diagnosis. We will reach end-users from all these sectors according to different commercial strategies that have been tailored to suit each type of customer. The main objective of this project is to increase the technical maturity of the platform and to validate its performance and operability in operational environment with different end-users. After this 24 months project, we will lauch QSEIF to the market with the aim of becoming an international reference in the diagnostic market. The viability of the technological, regulatory, market and financial aspects of the QSEIF innovation project were assessed through a feasibility analysis carried out in SME Instrument Phase I. From the analysis, we expect to install 717 devices that would perform 5.2M tests in a five year period. By then, QSEIF platform will bring an accumulated Net Profit of 5,32M€ by 2024. It is expected that sales of QSEIF will represent 40% of the company’s total revenue in 2021, growing to 88% by 2024.

Keywords: automatic pathogen detection,salmonella listeria staphylococcus,immunoassay,traceable,quality assurance,food safety,health,food waste
Synapses between Leukaemia and its Neighbouring Cells (SyLeNCe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Our understanding of the different layers of organization in tissues remains limited. Stem cell niches offer a tightly controlled environment and a unique opportunity to look into this question. Reductionist approaches have been proven highly efficient dissecting the complexity of stem cell niches in a unidirectional fashion. However, this approach fails to recognize the tri-dimensional complexity of tissue organization. Hence we propose a systems biology approach based on low input and single cell RNA sequencing of bone marrow niche populations in order to establish not only the molecular landscape of cells that comprise the stem cell niche in homeostasis and disease but also the lineage relationships that may exist between cells in the stroma. Using the mouse bone marrow niche during neoplastic transformation to acute myeloid leukemia (AML), we will first unravel the cellular and molecular interactions that constitute the tumor microenvironment during disease development and progression using multi parametric flow cytometry and RNA-sequencing. Information gathered from these experiments will also provide a list of molecular candidates for therapeutic intervention in AML. We will validate those candidate cell populations and genetic pathways by means of gain and loss-of-function assays in vitro and in vivo using murine models and primary human AML samples. Completion of our interdisciplinary project will provide, for the first time a complete transcriptional and cellular map of a tissue, revealing the heterotypic interactions that define the real nature of a tissue. Perhaps then we could start to appreciate the elegant complexity of the ecosystem that the stem cell and its niche share. I hope SyLeNCe will facilitate the description of novel vulnerabilities that could be explored therapeutically for the treatment of acute myeloid leukaemia having an impact on the quality of life and long-term survival of AML patients.

Keywords: acute myeloid leukaemia aml,bone marrow bm,microenvironment,haematopoiesis,leukaemia,initiating cells lics,peripheral blood pb
Characterization of the diversity and function of plankton associated microbiota (DYNAMO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-03
End date: 2018-10-02
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Ever since living organisms arose in the oceans, they have competed for resources and space. However, many planktonic species developed peaceful cooperation involving mutualistic interactions between two partners. Within unicellular eukaryotes, such symbiotic association between heterotrophic hosts and microalgae is widespread and sustain ecologically important taxa, such as the Rhizaria, in the open ocean. While knowledge of bipartite symbiosis has greatly improved, it is only recently that scientists disclosed more intricate relationships involving additional partners such as bacteria. Wherever bacterial communities (i.e. microbiota) have been found in tight association with other organisms (e.g. humans or plants), its critical role for the biology and ecology has been demonstrated. The DYNAMO project will explore the diversity of multipartite symbiosis in the plankton and characterize the cellular metabolites they produce. Radiolarians and foraminifers will be used as relevant model for marine ecology. An original combination of single-cell sorting and sequencing coupled with microscopy will be used to characterize and specifically localize the partners of the association. Then, a cutting-edge approach of single-cell metabolomics, of the different partners taken individually or together, will allow us to disentangle the role of the associations in the physiology of the holobiont. The exceptional metabolomics facility and knowledge on marine photosymbiosis available at the host institution, combined with the original analytical expertise at a partner organization, will bridge the gap between a descriptive approach and the functional understanding of the biological processes involved in plankton associated microbiota. DYNAMO provides an innovative perspective on marine ecological research and represents an important step in my career development with the ambition to place me as one of the very few experts in the field of plankton metabolomics in Europe.
PRediction of aerOdynamics and hinge moment loaDs at hIgh mach and fliGht rEynolds number (PRODIGE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Italy,Germany
Call: Prediction of aerodynamic loads at high Reynolds Number (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2021-09-30
Duration (months): 43.0
Total project cost (EUR): 2211276.24
EU funding (EUR): 2211276.24
Participants: 4
Project status: CLOSED

According to the requirements of the topic, the proposal PRODIGE will produce experimentally accurate loads and hinge moment data at high Mach and flight Reynolds numbers. The data will be the result of an experimental test campaign performed in the European Transonic Wind (ETW) tunnel; as a result they will be available for other future programmes to improve the loads and efficiency prediction of control surfaces. At this aim, the consortium PRODIGE has, first of all, to perform the design of the experimental setup. This means to design/ modify and manufacture all the required parts of an existing 1/16 scale model of a business jet according to technical requirements provided by the Topic Manager. In parallel, the consortium PRODIGE will design and manufacture a prototype hinge moment balance for the ailerons of the wind tunnel model including all the instrumentation necessary for the experiments. This hinge moment balance will be tested for calibration and validation in the cryogenic climate room VTCR by using a simplified mock-up and a suitable jig for loads application and for providing a connection to the chamber floor. The mock-up will be equipped with the aileron of the model or a similar control surface suitably modified to allow applying calibration loads. The validated design of the hinge moment balance concept will be then implemented in the final design of the wind tunnel model. A critical design review will close the design phase. Successively the model parts will be manufactured and the model assembled and sent to ETW premises where it will be tested against static loads in the climate room (VTCR) for measuring the elastic deformation of the wing, and then finally tested at several Reynolds and Mach numbers (flight conditions) and at several aileron deflection angles (the test matrix will be defined in agreement with the topic Manager) inside ETW.

Keywords: cryogenic wt model,flight reynolds number,advanced wt measurements,wt hinge moments,wt balances
Deciphering molecular mechanisms that resolve mutagenic DNA G-quadruplex structures (ReXeG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

G-quadruplex (G4) structures are stable four-stranded nucleic acids assemblies that can form in guanine-rich DNA. Their recent visualization in mammalian cells has established G4 structure formation throughout the genome and fueled research into understanding the biological implications of these structures in cell regulation. G4 sequence motifs are abundant and conserved in our genome. G4 structures form transiently and regulate numerous cellular processes such as DNA replication, transcription and telomere maintenance. Importantly, these structures also come at a cost as they are able to induce genomic instability in certain cellular conditions, for example in cancer cells that suffer from replication stress. Currently, the mechanisms that form and resolve G4 structures are unknown. Several helicases can unwind these stable DNA structures in vitro but it is unclear whether and how these helicases function in vivo. Understanding the biochemical mechanisms that resolve G4 structures is crucial to further understand their function and how they induce DNA mutations in the cell. In this project, I propose to decipher the molecular mechanisms of G4 structures unwinding. The groundbreaking nature of this proposal is the use of a unique method to follow G-quadruplex unfolding in time under near-physiological conditions in vitro. This method, which was recently established in the host laboratory, uses DNA replication stalling and bypass at defined G4 structures as a direct readout for G4 stability and unwinding. This gives me the opportunity to address important aspects that have not been studied under physiological conditions before: Aim 1: To determine the stability and unwinding properties of distinct G4 conformations. Aim 2: To identify molecular mechanisms and novel proteins in G4 unwinding. The results of this project will give important new insights into G4 regulation, an unexplored but important biological process.

Keywords: g quadruplex g4 structures,dna replication,xenopus egg extract,genome stability,dna protein interaction