Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transcription-induced Plectonemic Supercoiled DNA (TiPS-DNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

In our cells, DNA is extremely highly compacted to fit within the cell’s nucleus. While being compacted, the DNA still needs to remain accessible to various processes such as gene expression during the cell cycle. So how is DNA spatially organized? How does this compacted DNA interact with enzymes? Does compacted DNA superstructure have a biological role? Answering these daunting biological riddles through a targeted physics approach is the central motive of this proposal. I aim to investigate how supercoiled DNA plectonemes, the basic unit of DNA superstructure found in chromosomes, is linked to its biological functions in gene regulation. Throughout the proposed biophysics experiments in this project, I aim to obtain direct experimental proofs that reveal the mechanism behind the transcription-induced DNA supercoiling. I will co-visualize RNA polymerase interacting with supercoiled DNA in real-time and study the relevant dynamics during complex formation and transcription. To this end I will employ a novel single molecule in-vitro assay, Intercalation-induced Supercoiling of DNA. This assay utilizes intercalating dyes to induce supercoiling as well as to visualize the formation of DNA-plectonemes. The technique is solely based on fluorescence microscopy and allows for tracking DNA plectonemes and labelled enzymes with ease and with high-throughput. This project will provide the first direct evidence on the role of DNA supercoiling – a fundamental yet not-well studied phenomenon in cell biology – in mediating the activity of DNA-binding enzymes as well as on the origins of dynamic DNA supercoiling in the topological domains of the genome. The result of this project will be crucial for the understanding of the physical interactions that couple chromosome organisation to gene regulation.

Keywords: single molecule,dna supercoiling,plectoneme,transcription,rna polymerase,fluorescence
ScienceWars - May Science be with you! (ScienceWars)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal,Portugal
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-06-01
End date: 2020-01-31
Duration (months): 20.0
Total project cost (EUR): 188387.5
EU funding (EUR): 188387.5
Participants: 2
Project status: CLOSED

ScienceWars – May Science be with you! is the motto for a fun and ‘out-of-this-world’ battle for a more sustainable future. In line with the goal of ERN, ScienceWars is committed to create a bond between research/researchers and citizens, with a view of supporting public recognition of science and researchers, demonstrating the impact of researchers' work on daily life and encouraging young people to embark on research careers. As stated by Commissioner Carlos Moedas “There are few forces in this world as engaging and unifying as science”. ScienceWars will represent Science as the essential Force that surrounds us, improves our daily life and promotes our future, while making participants feel as they are being drawn into a magical world, one that’s being governed by scientific research. Through activities, demonstrations, and installations that educate, entertain, and inspire, ScienceWars will provide families and citizens at large, a greater appreciation of our ever-changing planet- and our relationship to it. The programme of activities (common to 2018/2019) will be dedicated to the main research areas in the Northern Region of Portugal – Health, Food, Energy, Environment and ICT -presenting itself as an ‘Intergalactic unifying Mission’, where participants will stand side-by-side with Luke ScienceWalker and ScienceTroopers, fighting for the sustainability of the Science Force! With an expected number of 50,000 visitors, at least 300 researchers directly involved and more than 500,000 people aware of the event, ScienceWars will take place in Porto, a UNESCO capital of culture and will be preceded by several activities (e.g. visits to schools and training actions). ScienceWars will be brought by INOVA+ (expert in educational & science events), the International Iberian Nanotechnology Laboratory (world-class research institution for science and innovation) and will be supported by Fundação de Serralves (contemporary art museum) and Juventude (Youth Foundation).

Keywords: bringing researchers and public at large,closer,stimulating young people to embark on scientific careers,combining education and,entertainment
Animated Language Learning Ltd (ALL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Animated Language Learning is an Irish high growth company, driving forward a ground breaking innovative approach to the development and education of children with autism. The core team is led by Enda Dodd CEO, a Fortune 200 (Medical devices) New Product Development VP; and Valerie Dodd, head of product development, as well as a teacher/psychologist. Our two product development professionals, Conor and Eoin Dodd, have emerged from Autism, thanks to the ALL approach. Our team benefits from inputs from global key opinion leaders across relevant clinical, technical, educational and commercial areas including the University of California and National University Ireland Galway (NUIG), Disney, Adobe, Microsoft and Google are also supporting our efforts. We are a global developer of language development tools for Autistic children (ASD) with our first commercial offering currently undergoing pilot studies in the US, UK, Canada, Ireland and Australia. Children diagnosed with autism fail to develop communication skills and face long term societal dependency and institutionalisation. The US centres for disease control (CDC) reports US Incident rate is approximately 1:68 births and further that European and Asian rates are similar . Annual costs associated with treating this condition in the US and UK alone across clinical, educational, custodial and lost earnings have been estimated to be $283 billion for a total ASD (autism) population of 4.5 million. Despite substantial differences in healthcare policies in the two countries, life time costs associated with the condition were similar. Multiple peer reviewed studies collated by the CDC indicate that ASD prevalence in Europe and Asia is commensurate with the US / UK study. We have developed a fundamentally different, life-changing and effective technology which is significantly lower cost, capable of unlocking the potential of those diagnosed with ASD so they can make a contribution to society instead of being a burden.

Keywords: animated language learning autism
U-space Separation in Europe (USEPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Germany,Germany,Spain,Norway,Norway,Belgium
Call: U-space (H2020-SESAR-2019-2, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 1999308.75
EU funding (EUR): 1999308.75
Participants: 7
Project status: CLOSED

The U-space concept was the response of the Warsaw Declaration in 2017 to use drones as a leverage for jobs and new business opportunities. The U-space Blueprint published by the SESAR Joint Undertaking in 2017, states that “U-space is a set of new services and specific procedures designed to support safe, efficient and secure access to airspace for large numbers of drones”. The number of drones' applications is increasing and, with them, the number of drones that will be flying simultaneously in a same geographical area that will need to be safely separated between them and from manned aircraft to allow the maximum number of flights in a given airspace. The separation problem becomes even worst when flights take place in an urban environment where buildings and extreme turbulent wind shear appears close to them. USEPE is aware of these problems and will research on drones’ separation methods in high demanding environments such as cities. This research will be accompanied by a concept of operations that will be implemented and simulated for its validation. USEPE will also research on the use of machine learning algorithms to automate the safe separation and deconfliction of drones while maintaining airspace capacity in different environments and provide the U-space separation management system with artificial intelligence to comply with the statement made in the European ATM Masterplan Roadmap for the safe integration of drones into all classes of airspace. “[…]to take advantage of the latest developments related to technological areas, such as artificial intelligence […]”. In order to obtain valuable results, a casuistic of real urban scenarios will be defined and their feasibility will be assessed to select and implement the more suitable ones and perform a full validation by using the European Operational Concept Validation Methodology (E-OCVM). The research approach will take into account both the strategic and tactical flight phases.

Keywords: u space,drones,artificial intelligence,machine learning,separation,deconfliction,service provision,u space service providers
Eco-friendly corrosion protective coatings based on smart nanotechnology platforms for a circular economy (COAT4LIFE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Estonia,Germany,Estonia,Lithuania,Norway,Belarus,Latvia,Czechia,Czechia,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-05-01
End date: 2025-04-30
Duration (months): 48.0
Total project cost (EUR): 570400.0
EU funding (EUR): 570400.0
Participants: 11
Project status: SIGNED

The need to develop and use products made out of residues or sub-products from industry is creating pressure over fields where more traditional, linear economy concepts prevail. In this project we address one important stage of the life cycle of products, particularly trying to extend its service life, thereby contributing for advances towards circular economy via increase in durability of materials and use of greener materials. In particular, this proposal addresses the problem of protection and monitoring of corrosion of metallic substrates used in different applications. Structured in previous experience with a recently finished MSCA-RISE project SMARCOAT (ref. 645662, 2015-2018), this project aims at developing eco-friendly multifunctional coatings with capacity to protect and detect corrosion based on different mechanisms combining nanostructured inhibiting and sensing additives. Two types of coating systems are intended to be developed, one for temporary protection during storage and transportation based on biodegradable materials and another on thermosetting polymers obtained using raw materials from sustainable sources. A relevant part of this project includes the study of fate and ecotoxicity of different coating components and Life cycle analysis, which will be equaled as a figure of merit with performance factors to select the most promising systems and launch demonstrators for standard and field tests.

Keywords: nanostructured materials,magnetic nanoparticles,controlled release,anticorrosion,corrosion,sensing,modeling,metallic substrates,aeronautical,maritime,life cycle assessment,circular economy
Advanced Electrochemical Treatments for Cork Washing Wastewater Remediation towards a Circular Economy (E-CORK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-28
End date: 2024-01-27
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: TERMINATED

With 162,000 tons/year, Portugal and Spain have the largest world quota of cork production, being cork stoppers for wine and champagne the “star product”. About 90% of the cork stoppers used worldwide are produced in these two countries. The European Cork Federation established mandatory practices to ensure the quality of the natural stoppers which include several washing, bleaching and disinfection steps. These procedures generate large volumes of wastewaters up to 195,000 m3/year that contain non-biodegradable organic matter, hydrogen peroxide used as disinfectant and different dissolved salts; and constitute a serious risk to environment and human health. The E-CORK project builds on the premise that cork washing wastewaters can be effectively treated by electrochemical advanced oxidation processes. The main goal is to develop an optimized electrochemical treatment line for the depuration and reutilization of cork washing wastewaters taking advantage of the hydrogen peroxide in the main effluent (from by-product to reactant), attending not only to the treatment performance, but also to its technical, economic and environmental feasibility. With this approach and bearing in mind the possibility of reuse the regenerated wastewaters, the E-CORK project aims to revolutionize the cork industry towards a circular economy. The inherent responsibility of Portugal and Spain R&D to promote cleaner and more cost-efficient technologies that safeguard cork production and aquatic environments; the close link with the industrial needs; and the experience of the candidate and supervisor at University of Coimbra, make the perfect conditions to successfully develop this project.

Keywords: cork industrial wastewater,electrochemical processes,advanced oxidation processes,life cycle assessment
Towards user journeys for the delivery of cross-border services ensuring data sovereignty (ACROSS)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Spain,Belgium,Greece,Greece,Latvia,Netherlands
Call: New forms of delivering public goods and inclusive public services (H2020-SC6-GOVERNANCE-2020, 2020)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 3998312.5
EU funding (EUR): 3998312.5
Participants: 11
Project status: SIGNED

In recent years, the concept oIn recent years, the concept of cross-border services and data exchange has been an essential part of development in the EU where the services are provided using ICT in an interoperable environment. Since the data exchange is a long way journey, the EC has initiated the Single Digital Gateway Regulation (SDGR) as an important step to implement the digital revolution in Europe. SDGR brings various services under the same roof to set rules and guidelines on how to implement uniform public services in the member states. However, issues related to the digitisation of services, easy access to information and procedures and new challenges still need to be addressed in order to enable innovation and growth of EU single market. The operation of the SDG is a meaningful step forward in helping cross-border clients to solve many procedures and receive the necessary assistance; however, it should be facilitated by providing the user a guidance in an interactive, easy-to-follow and user-friendly way. Towards these challenges, ACROSS proposes a novel framework aiming to substantially comlement SDG and Your Europe portal by leveraging the advanced capabilities of Cloud, privacy-preserving, semantic interoperability, and mobile technologies, to build the next generation Public-Services ecosystem while maintaining the highest privacy level. ACROSS aims to enable user-centric design and implementation of interoperable cross-border public digital services compliant with the current European regulations where the private sector can also interconnect their services while ensuring the data sovereignty of the citizens. ACROSS will be developed and tested in three countries at different points in their digital transformation journeys – Greece, Germany, Latvia – will address and analyse the technological, organisational, administrative, semantic and legal aspects, providing evidence for delivering more efficient cross-border mobility services to the citizens.

Keywords: single digital gateway,european interoperability framework,data governance,cross border digital services,citizen mobility,isa2,co creation,co delivery,user journey,virtual assistant,mobile
Accelerate co-creation by setting up a multi-actor platform for impact from Social Sciences and Humanities (ACCOMPLISSH)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Germany,Spain,Estonia,Estonia,Italy,Italy,Belgium,Croatia,Hungary,Sweden,Netherlands,Denmark,United Kingdom,United Kingdom,Portugal
Call: Enabling Innovation - Creating Impact from Social Sciences and Humanities (H2020-REFLECTIVE-SOCIETY-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1898412.5
EU funding (EUR): 1898412.0
Participants: 16
Project status: CLOSED

Traditional valorisation approaches focus on linear processes: from academia to society. In order to bring valorisation to a higher level, all relevant actors need to cooperate in an equal setting: co-creation. Co-creation transcends boundaries, but it does not happen naturally. Therefore, the ACCOMPLISSH consortium, consisting of 14 universities from 12 countries (representing all the sub disciplines in SSH), will actively involve the other partners from the so called Quadruple Helix (industry, governments and societal partners) within the project. The project has chosen an Open Innovation approach. The ACCOMPLISSH project (Accelerate co-creation by setting up a multi-actor platform for impact from Social Sciences and Humanities) will create a platform for dialogue where not only universities are involved. The dialogue platform is organised in such a way that academia, industry, governments and societal partners equally contribute in identifying barriers and enablers of co-creation. The results from both practice and the theory of co-creation form the basis of the valorisation concept and will be tested in the project in a quadruple helix setting. This concept will be tested and developed in such a way that it is transferable, scalable and customized for academia, industry, governments and societal partners in the whole of Europe. The impact profile of SSH research could be far stronger and more visible than it currently is. There are significant barriers to the valorisation of SSH research which still need to be understood in detail. In order to push the envelope within universities, we acknowledge that next to SSH researchers, the research support officers are key players in valorisation of SSH research. The project will identify all barriers and enablers of co-creation in order to develop an innovative valorisation concept, which will foster knowledge exchange within the quadruple helix and strengthens the position of SSH research.

Keywords: valorisation,co creation,knowledge exchange,quadruple helix,impact,open innovation
When Flows Turn Turbulent in the Supercritical Fluid Region (CRITICAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1924020.0
EU funding (EUR): 1924020.0
Participants: 1
Project status: SIGNED

From concentrated solar power plants to rocket engines, energy conversion systems are continually re-engineered to perform ever better. Often this involves fluids being pushed into the supercritical region, where highly non-ideal thermodynamic effects are at play. Yet, our fundamental understanding of flow physics at such conditions lags behind to successfully realize these exciting engineering applications. Especially, the sharp variations in thermophysical properties and the high optical density at supercritical pressures lead to significantly richer flow physics and even more intricate phenomena in turbulence. In three work packages, I will (1) elucidate laminar-turbulent transition; (2) unravel compressible effects on turbulence; and (3) unveil turbulence-radiation interactions, ranging from the critical point to conditions far into the supercritical region of a fluid. Exploiting my recent achievements, I will perform the first study of its kind, combining advanced hydrodynamic stability analysis, novel multi-physics simulation tools, and original experiments with infrared thermography to identify and characterize new flow physics in the supercritical fluid region. The results will reveal how and when flows in the non-ideal region transition to turbulence, how strong compressibility affects turbulent heat transfer, and how the higher optical density of a fluid interacts with turbulence. Uncovering these mechanisms will actively contribute to a breakthrough in a wide range of emerging technologies, from utility-scale concentrated solar power plants to more powerful and efficient propulsion systems.

Keywords: supercritical fluids,energy,propulsion,turbulence,radiation,fluid mechanics