Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ADVANCED ANTIGEN-SPECIFIC DENDRITIC CELL-BASED THERAPY TO RE-ESTABLISH TOLERANCE IN IMMUNE-MEDIATED DISEASES (IMMUTOL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Netherlands,Germany,Hungary
Call: Pre-clinical development of the next generation of immunotherapies for diseases or disorders with unmet medical needs (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 5999340.0
EU funding (EUR): 5999340.0
Participants: 11
Project status: SIGNED

Autoimmune diseases are currently treated with immunosuppressive and supportive therapies, which dampen inflammation, but do not stop the cause of the disease and are required life-long. Thus, there is an unmet need for safe and effective therapies for these diseases, which are well-tolerated and targeting the cause of disease. Tolerogenic dendritic (DC) cell-based therapies, offer the possibility of restoring immune regulation leading to long-lasting effects. Vitamin (Vit)D3-modified tolerogenic DC have been recently applied to Multiple Sclerosis (MS) patients in Phase I trials, demonstrating safety, tolerability, feasibility, and preliminary evidence of an effect. Molecular characterization of VitD3DC from MS patients suggests that they own less tolerogenic properties than those from healthy individuals. Thus, correcting these deficiencies through gene transfer could improve their effectiveness. The aim of IMMUTOL is the fast-track development and validation of an advanced therapeutic medicinal product (ATMP) based on VitD3-modified tolerogenic DC for immunotherapy approaches. Through a multidisciplinary approach, IMMUTOL will leverage the power of tolerogenic VitD3DC-based immunotherapy to develop a more potent and durable treatment for MS and, in turn other autoimmune inflammatory diseases with an unmet medical need. In parallel, it will bring information about tolerance mechanisms and patient-specific requirements for manufacturing effective tolDC products. Results will lead to design of a clinical protocol according to the regulatory requirements for the first-in-man application of engineered tolerogenic VitD3DC in MS patients.

Keywords: tolerogenic dendritic cells,tolerance,vitd3,cell therapy,autoimmune diseases,multiple sclerosis,auto inflammation,advanced therapeutic medicine product,lentiviral vectors,genetic manipulation
Photoactive Metal-Organic Framework for Solar-Driven Atmospheric Water Harvesting in Arid Climates (PHOTOWAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Atmospheric water harvesting (AWH) using solar energy has gained significant attention; however, its application in arid climates poses challenges due to low relative humidity (RH) and reduced efficiency of conventional sorbents. metal-organic frameworks (MOFs) are a class of porous materials with an engineerable structure that have the ability to capture water even at very low RH. Usually, the combination of photothermal materials with MOFs is used to desorb water sorbed by MOFs. One of the challenges of this method is the reduction of MOF sorption capacity, which is very unfavorable, especially in arid climates. Reducing the performance of sorbents in arid climates due to the blocking of sorption sites by dust is another challenge that has received little attention so far. To address these challenges, this study evaluates the synthesis of a unique water-stable MOF with photothermal and photocatalytic (photoactive) properties (PAMOF), in addition to high water affinity. Phthalocyanine and porphyrin ligands decorated with Ti and Cu ions, along with Yttrium (Y) and Erbium (Er) clusters, are considered as promising candidates. Molecular modeling using density functional theory (DFT) will be conducted to guide the synthesis process, followed by experimental synthesis and characterization. Subsequently, the samples will be evaluated in an AWH device to assess short-term efficiency and long-term maintenance in real conditions. In addition to harnessing natural solar energy, the AWH experiments will involve the utilization of a custom-made solar simulator. The SAWH device will be evaluated across a range of RHs, spanning from 10% to 90%, while considering the presence of artificial dust. Through comparative analysis of existing research and with the aim of enhancing previously studied systems, this project endeavors to attain a daily water evaporation rate surpassing 4 kgwater/kgPAMOF under 1 sun and RH<30.

Keywords: atmospheric water harvesting awh,arid climates,metal organic framework mof,photothermal,photocatalytic
SEASTARS: SUSTAINABLE EMISSION ABATEMENT STRATEGIES & TECHNOLOGIES FOR ADVANCED REVOLUTION SHIPS (SEASTARS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: United Kingdom,Netherlands,Greece,Italy,Liberia,Spain,Switzerland,Marshall Islands
Call: Combining state-of-the-art emission reduction and efficiency improvement technologies in ship design and retrofitting for contributing to the "Fit for 55" package objective by 2030 (ZEWT Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 9850143.75
EU funding (EUR): 7183927.25
Participants: 19
Project status: SIGNED

SEASTARS main objective is to demonstrate a well-to-wake GHG emissions reduction of minimum 30% by 2030 (compared to 2008) as well as a 20% energy efficiency improvement (compared to 2022 reference performance) on eight market-ready vessel designs (4 retrofits and 4 newbuilds) addressing inland, short and high-seas shipping by combining different emission reduction and efficiency improvement technologies that will be market ready by the end of the EU project. The project aims at incorporating different technical efficiency measures directly related to the vessel’s hydrodynamic, by propeller-hull optimization and air lubrication implementation, the vessel’s machinery, by selecting different technologies such as fuel cells, electric motors, integrated solar panels, sails and electrochemical storage systems, and the vessel’s Energy, by exploring different alternative fuels such as biofuels, hydrogen, methanol, LNG, ammonia and different energy treatment systems like fuel preparation, fuel reforming, cold ironing, pre-combustion and post-combustion Carbone Capture Storage (CCS). Through the use of an advanced design methodology derived from Systems Engineering (SE), known as Model-Based Systems Engineering (MBSE) and a phased assembly-to-order approach, SEASTARS will help shipowners not only to evaluate the vessel’s emission reduction and efficiency enhancement but also to generate appropriate action-time plans for the decarbonization process and to quantify the related investment decisions, so to adapt their fleet to be always in line with the imposed regulation. Emission reduction and efficiency improvement technologies are designed as modules that can be added, scaled up or replaced in phases over time into a ship that is designed in a flexible and traceable way, enabling decreasing emissions progressively while maintaining a reasonable investment risk, controlled by the shipowners.
Metal-Induced Energy Transfer based Electrometry and Nanometry: Dissecting Electrostatic Phenomena in Biological Processes (MIETEN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2495360.0
EU funding (EUR): 2495360.0
Participants: 3
Project status: SIGNED

Almost all biological processes, involving molecular trafficking, signal-transduction, cell-to-cell interactions, hinge on precisely orchestrated electrostatic interactions, arising from electrical charges on biomolecules and membranes. Yet, our understanding of the role of electrostatics in these fundamental processes remains elusive due to the absence of quantitative methods to measure the electrical charges of biomolecules and to map the surface charge distribution of membranes. This challenge is further compounded by the requirement of capturing molecular and membrane dynamics that take place at the nanometre length scales and nano- to sub-millisecond time scales. The overall objective of this project is to bridge this technological gap by introducing Metal-Induced Energy Transfer based Electrometry and Nanometry (MIETEN), a groundbreaking technology that will quantify the electrical charge of biomolecules or membranes while capturing their dynamics with nanometre spatial and microsecond temporal resolutions. We will demonstrate MIETEN for measuring: (i) the charges and sizes of individual membrane proteins, (ii) membrane protein structural changes, conformational dynamics, and spatial organization in response to changes in membrane potential, (iii) reaction-diffusion kinetics at a charged membrane, (iv) mechanical properties and dynamics of membranes containing charged inclusions and (v) interactions between two charged membranes. The ability to measure biomolecular and membrane electrical charges and to elucidate the role of electrostatics in structure, organization, and interactions of proteins, as well as in membrane dynamics and intermembrane interactions, will be crucial for our understanding of fundamental biology and for advancing biomedical research. MIETEN will open new frontiers in studying protein and membrane dynamics and impact drug development, early diagnostics, and therapeutic interventions.

Keywords: super resolution microscopy,fluorescence spectroscopy,biophysics,electrostatics
Cognitive Aspects of Mithraic Rituals in Pannonia (CAMRIP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2025-01-31
Duration (months): 30.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: CLOSED

Traditional scholarship focusing on the examination of archaeological material from the Roman province of Pannonia has ignored cognitive and sensory theoretical approaches, particularly when it comes to the study of Roman religion and ritual. Although the cult of Mithras was extremely popular in Roman Pannonia, we still know little about 1) how ritual practices were learned, performed, remembered, diffused and transformed between different Mithraic communities in Pannonia, and 2) how Mithraic religious networks were formed. My research project aims to bridge this gap in scholarship by applying interdisciplinary cognitive and sensory theoretical perspectives to the analysis of archaeological, epigraphic and iconographic evidence for the cult of Mithras from various Pannonian settlements, in order to investigate and answer 1) and 2). I hypothesize that the project will demonstrate that Mithraic communities throughout Pannonia exhibit localized variations of ritual practices, thereby challenging traditional interpretations of homogeneity of Mithraic ritual. The project will be developed as a series of case studies, where evidence from Mithraic communities and settlements across Pannonia will be analyzed, compared and contrasted. These case studies will be published in the form of peer-reviewed articles. The University of Vienna is the ideal place to conduct this research, firstly because of Vienna's archaeological heritage as an important Roman Pannonian settlement; secondly because of Vienna's museums, archives and libraries which hold Austro-Hungarian excavation reports and archaeological materials; and thirdly due to Vienna's strategic location on the Roman Danube frontier and its proximity to many other Pannonian archaeological sites. Most importantly, collaboration with Prof. Dr. Günther Schörner, a leading international scholar on Roman rituals and cognition, will enable me to broaden my research expertise and contribute to research output at UNIVIE.

Keywords: roman religion,roman provincial archaeology,roman pannonia,mithras,ritual,latin epigraphy,cognition,cognitive science of religion
AI-Enhanced fibre-Wireless Optical 6G network in support of connected mobility (6G-EWOC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Spain,France,Denmark,Israel,Austria,Switzerland,Sweden,Greece
Call: Communication Infrastructure Technologies and Devices (HORIZON-JU-SNS-2023, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4221303.0
EU funding (EUR): 3999338.84
Participants: 12
Project status: SIGNED

The 6G-EWOC project aims to contribute to the development of future 6G-AI based networks by ending with TRL-4-level developments on critical technologies and devices for expanding the reach of 6G, especially in high mobility scenarios. It is addressing Key Societal Value indicators (KVI) defined by the Work Programme and developing KV enablers such as services for coordination, precise positioning and localization, multi-agent supporting network architecture and joint communication and sensing. The three ambitions of 6G-EWOC focus on: AMB1, Optical Wireless Communications (OWC) for V2V and high-rate (Gb/s) V2I applications, chip-scale optical beamformers, and developing connected laser/radio detection, ranging, and communication (Lidar/Radar). AMB2, PIC and ASIC for tuneable transmitter and receiver concepts for fiber-based fronthaul supporting 50 Gbps and 100 Gbps per wavelength over DWDM fiber links and SDN-enabled photonic switching. AMB3 focuses on AI-assisted control and orchestration of resources for the multi-band, heterogeneous 6G-EWOC network concept and AI-based applications development for autonomous vehicles. Up to 17 KPIs are expected to be validated at three final demonstrations. In conclusion, 6G-EWOC search to develop an AI-enhanced fibre-wireless optical 6G network in support of connected mobility by creating a new access network for high mobility scenarios and expanding the reach of 6G through the integration of optical and wireless technologies, free space optics, and joint communication and sensing. It is supported by a fast, reconfigurable, highly dynamic, and customizable optical fiber fronthaul infrastructure, minimizing optoelectronic transitions by tuneable and programmable devices and low energy photonic switching of (packet/optical) spectrum and spatial resources, controlled by AI-based SDN. Providing end-to-end connectivity between AI-based edge computation units supporting connected mobility in a fast reconfigurable network architecture.

Keywords: hybrid rf fso communications,optical wireless,optical fibre,radar,lidar,fronthaul communication,6g,ai
EUropean RobotIcs for Space Ecosystems (EU-RISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Germany,France,Spain,Austria,Greece,United Kingdom
Call: Future Space Ecosystem and Enabling Technologies (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2023-12-01
End date: 2026-01-31
Duration (months): 26.0
Total project cost (EUR): 3082583.11
EU funding (EUR): 2324917.93
Participants: 9
Project status: SIGNED

The maturation of space robotics has paved the way for new capabilities for in-space servicing, assembly and manufacturing (ISAM). These capabilities offer significant business opportunities and promise to increase the efficiency and resilience of the orbital infrastructure. It will open a completely new market with the potential to shape a new ecosystem in space. In order to seize this opportunity and prevent US companies from monopolizing the market, a European ISAM capacity must be built up. The project has two distinct goals: First, to undertake a market analysis of in-space services, in-space assembly and manufacturing, and related domains, and develop two reference scenarios that will be further analysed and used to define an end-to-end demonstration scenario. Second, to use the demonstration scenario to mature the building blocks and relevant robotic elements that have been started to be developed in Europe during the last years and to establish an open-source process for the continuing maturation of these building blocks. The establishment of a European ISMA capacity and defining the future space ecosystem will have a significant impact on Europe. By developing and implementing these new capabilities, Europe can maintain its competitiveness on the global stage, create new jobs, and drive economic growth through increased investment in the space industry. Furthermore, the development of a sustainable space ecosystem will have a positive impact on the environment, reducing the amount of waste and pollution in space and contributing to a more sustainable and cleaner space environment. Overall, the project's impact on Europe is multifaceted and far-reaching, including economic growth, job creation, technological innovation, and environmental sustainability. By creating a European ISAM capacity and defining the future space ecosystem, Europe can position itself as a leader in the global space industry and pave the way for a more sustainable and prosperous future.

Keywords: future space ecosystem,transportation,in space manufacturing and assembly,isma,oos,space station assembly and maintenance,recycling,open source
FORMATION OF HIGH-VALUE DENSE PLANT BIOCONDENSATES (PlaBioC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

We need to turn our production systems upside down! Instead of using fossil fuels and release carbon dioxide, we need to shift to biobased production with carbon dioxide as the sole carbon source. In nature, this is already done at a scale feeding the world’s human population. The process used in nature is photosynthesis. This environmentally benign production system needs to be expanded to include the synthesis of high-value compounds that are not currently produced in photosynthetic systems or produced in low amounts. When produced in high amounts, these different types of high-value natural products need to be stored without being auto-toxic to the production host. This is where storage in dense biocondensates becomes a key success parameter. Biocondensate formation in plants is a “black box”, but proposed mechanisms point to phase partitioning induced by proteins with intrinsically disordered domains or by NAtural Deep Eutectic Solvents (NADES). NADES are compounds like sugars, amino acids, organic acids, and choline that when mixed in specific stoichiometric ratios have a lower melting point than the individual components. Certain plants manage to accumulate natural products in very high amounts without autotoxicity or cell homeostasis problems. This is the case in my two proposed experimental systems: Vanilla planifolia, which accumulates vanillin glucoside at 2.2kg/L levels in the plastids of the maturing pods; and Sorghum bicolor that produce the defence compound dhurrin, in amounts reaching 30% of the dry mass in etiolated seedlings. In order to identify the players involved in biocondensate formation, I will combine methods of cellular and organelle isolation with imaging and state-of-the-art analytic chemistry, metabolomics, and transcriptomics. Studying how plants orchestrate the formation of dense biocondensates to store high-value compounds in high amounts would be key to make green bio-production systems feasible.

Keywords: plant metabolism,biocondensates,eutectic solvents,nades,intrinsically disordered region,phase separation,vanilla orchid,sorghum,vanillin,dhurrin,high value compounds,natural products