Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enzymatic SO2 biosensor for rapid food safety monitoring (SO2SAFE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Spain
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Overall objective of the SO2SAFE Project is to develop a new miniaturized ready to use biosensor based on disposable screen printed electrodes (SPE) which will allow a highly sensitive, selective, fast, low-cost and user friendly method for determination of sulphites in crustaceans, since this is a type of food where the sulphite is commonly used. The novel solution will have a direct impact not only in the food industry economy, but also in the society due to the direct impact the sulphite has in health. In order to achieve this main objective, the following specific objectives will be targeted: • Design and fabrication of disposable and high reproducible SPE that can be mass manufactured by microfabrication technologies. • Biofunctionalization of SPE with a specific enzyme for sulphites detection. • Development of a fast, simple and user-friendly miniaturized measure device for SPE lecture. • Development of a reproducible large-scale fabrication methodology (scale-up) that allows the commercialization of the ready to use pre-calibrated solution in order to simplify analysis by eliminating pre-analytical steps. BIOLAN has already developed at the laboratory scale a simple, reliable and specific enzymatic biosensor for sulphite determination and has obtained relevant data that support the innovative project here proposed versus the other methods currently available. Based on these data, BIOLAN expects to address the above listed objectives and become ready to give answer to the expected demand first in the specific market segment of crustaceans and later to open new market opportunities in other sectors such as wine, juices, etc. Through the Phase 1, BIOLAN will be able to better study the feasibility of the here proposed innovation project and design in the more accurate way the breakthrough innovation activities to be developed during Phase 2, opening new market opportunities that will be reflected in the company growth and internationalisation.

Keywords: biotechnology,biosensor,enzymatic,sulphite,food safety,health,scale up fabrication,accuracy,device,global market,feasibility,rapid,simple,user friendly,monitoring
MontEENegro (MontEENegro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Montenegro
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 7175.0
EU funding (EUR): 7175.0
Participants: 4
Project status: CLOSED

Enterprise Europe Network is a main support instrument for innovation in SMEs. It will provide innovation support services as well as information and advisory services such as mentoring, coaching and partner search activities for SMEs wishing to develop cross-border innovation projects. Innovation support, as a service that EEN Montenegro will deliver, will be offered through two packages - Key Account Management (KAM) to support the innovation capacity of successful “SME instrument” applicants benefiting from Horizon 2020 specific supporting mechanism, and Services to enhance the innovation management capacity of SMEs in Montenegro in order to improve their effectiveness and efficiency, in particular aimed at those with significant innovation activities and a real potential for international growth.
Adaptive, Trustworthy, Manageable, Orchestrated, Secure, Privacy-assuring, Hybrid Ecosystem for REsilient Cloud Computing (ATMOSPHERE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Israel,Spain,Italy,Greece,Portugal,United Kingdom
Call: Cloud Computing (H2020-EUB-2017, 2017)
Start date: 2017-11-01
End date: 2019-10-31
Duration (months): 24.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 10
Project status: CLOSED

ATMOSPHERE (Adaptive, Trustworthy, Manageable, Orchestrated, Secure Privacy-assuring Hybrid, Ecosystem for REsilient Cloud Computing) is a 24-month project aiming at the design and development of an ecosystem of a framework, platform and application of next generation trustworthy cloud services on top of an intercontinental hybrid and federated resource pool. The framework considers a broad spectrum of properties and their measures. The platform supports the building, deployment, measuring and evolution of trustworthy cloud resources, data network and data services. The platform is demonstrated on a sensitive scenario to build a cloud-enabled secure and trustworthy application related to distributed telemedicine.

Keywords: trustworthy clouds,hybrid systems,security,privacy,virtualization,platform as a service,federated virtual networks,data analytics,container management,serverless applications
Ecosystem of Advanced ICT-based Services Personalised Training for Efficient Secure Driving (GlobalBLED)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 1591343.75
EU funding (EUR): 1113940.63
Participants: 1
Project status: CLOSED

Opportunity: Professional fleets market faces important challenges to meet EU strategies while optimizing their own business because of (i) their constant need to reduce operative costs without decreasing service quality. (ii) their obligation to gradually reduce CO2 emissions following the EU strategies and policies (iii) their need to increase workers and citizens’ safety and as a result transport security minimizing accidents. Added value proposal: GlobalBLED aims to deliver an advance quality, secure (+25%), personalized, eco-efficient support driving platform that achieves fuel consumption savings (10%) and so accomplishes operative costs and CO2 emissions savings (10%) with a ROI> 250% per vehicle. GlobalBLED provides an innovative personalized learning-by-doing driving support service thorough Smart Tools and a net of Certified Agents, under established traffic rule standards for each context, increasing transport safety, including users and pedestrians, and therefore mobility sustainability. Objectives of Phase 2: The main objective of this proposal is to reduce the time to market and scale up production of the GlobalBLED to reach the stage of market ready innovative product (from TRL 7 to TRL9) by further (i) developing product key innovation aspects & optimizing production (ii) deploying two great scales iterations of demo pilots covering 3,000 drivers of 3 different types of fleets (iii) ensure market replication scale-up creation a network of providers & distributors worldwide Expected outcomes: After 5 years GlobalBLED solution operating in 150 clients; more than 17 countries, 89,5 thousand drivers, 336 thousand CO2 Tons saved yearly. Passing from total revenues of 685 k€ in 2015 to 39.5 million euros by 2023 with an EBITDA of 65%.

Keywords: eco mobility,efficient driving,sustainable transport
The first Trans-continental Networking Academy for African and European Digital Innovation Hubs (AfriConEU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Uganda,Italy,Greece,Slovenia,Tanzania, United Republic of,Greece,United Kingdom,Portugal,Ghana,Nigeria
Call: International partnership building between European and African innovation hubs (H2020-ICT-2020-2, 2020)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 2229937.5
EU funding (EUR): 1999706.25
Participants: 11
Project status: SIGNED

The AfriConEu project envisions to essentially strengthen and reinforce the digital innovation ecosystems in Africa by targeting existing Digital Innovation Hubs (DIHs) and supporting them through capacity building and networking activities. African DIHs are playing a central role in the development of digital entrepreneurship and by raising their capacities to tackle the challenges they face they will be more effective in driving digital innovation forward. To achieve its mission, the AfriConEu project will connect DIHs from Nigeria, Uganda and Tanzania with DIHs from Europe with the aim to (i) facilitate knowledge and experience sharing, (ii) drive the development of mutually beneficial partnerships and (iii) support the creation of collective projects for boosting digital economy, empowering youth and fostering innovation and growth. To realize its mission the project will develop, test and validate the “AfriConEu Networking Academy” an innovative mechanism for connecting and sharing best practices, experiences and resources between DIHs in Africa and between DIHs in Africa and EU, in a comprehensive, replicable and self-sustaining way. Through two flagships programmes, the AfriConEu Networking Academy will empower and enable African DIHs to best serve their local industry, boost their start-up ecosystem and empower the youth population with the necessary skills to thrive in a digitalized world.

Keywords: digitalization,co creation,international cooperation,digital startups
Glioma on a chip: Probing Glioma Cell Invasion and Gliomagenesis on a Multiplexed Chip (GliomaChip)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Türkiye
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 157355.52
EU funding (EUR): 157355.52
Participants: 1
Project status: CLOSED

28% of all primary brain tumors and central nervous system tumors and 80% of malignant tumors are gliomas, which arise from the supportive tissues in the brain. Yet, our ability to effectively treat these cancers is limited by our knowledge of the disease and our ability to test new treatments on accurate models. Advances in microfluidics and cell encapsulation within hydrogels have made significant strides in trying to meet these needs, but the potential to use these technologies for engineering physiologically relevant tissue models has yet to be fully realized. Here, we propose to investigate cancer biology using a microfluidic device with three-dimensional (3D) micro-patterned cellular constructs that may be subjected to flow through microfluidic channels. Using the developed model, we aim to understand the cellular gliomagenesis, glioma cell migration, and angiogenesis and further test drug susceptibility to demonstrate the relevance of the proposed model. To achieve these goals, I have formulated an innovative and interdisciplinary strategy based on my research experience in bottom-up tissue engineering and microfluidics, and brought together a strong team. First, I will receive an intensive training at the Max Planck Institute for Intelligent Systems on micro-robotics to strengthen the bridge between the fields of micro-robotics and bottom-up tissue engineering. Then, I will get a training at the Harvard Medical School on glioma cell culture and cell extraction from a mouse model. Finally, all these efforts will be integrated into the development of an in vitro 3D glioma-on-a-chip model mimicking the complex in vivo microenvironment of glioma. The successful completion of this timely and innovative project will result in an advanced microphysiological system that will contribute to the competitiveness of Europe in the fields of cancer management, pharmaceutics, and personalized medicine.

Keywords: micro robotics,glioma,organ on a chip,microfluidics,tissue engineering
Harvesting dark plasmons for surface-enhanced Raman scattering (DarkSERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-09-30
Duration (months): 78.0
Total project cost (EUR): 2299506.0
EU funding (EUR): 2299506.0
Participants: 1
Project status: SIGNED

Metal nanostructures show pronounced electromagnetic resonances that arise from localized surface plasmons. These collective oscillations of free electrons in the metal give rise to confined electromagnetic near fields. Surface-enhanced spectroscopy exploits the near-field intensity to enhance the optical response of nanomaterials by many orders of magnitude. Plasmons are classified as bright and dark depending on their interaction with far-field radiation. Bright modes are dipole-allowed excitations that absorb and scatter light. Dark modes are resonances of the electromagnetic near field only that do not couple to propagating modes. The suppressed photon emission of dark plasmons makes their resonances spectrally narrow and intense, which is highly desirable for enhanced spectroscopy as well as storing and transporting electromagnetic energy in nanostructures. The suppressed absorption, however, prevents us from routinely exploiting dark modes in nanoplasmonic systems. I propose using spatially patterned light beams to excite dark plasmons with far-field radiation. By this I mean a beam profile with varying polarization and intensity that will be matched to the dark electromagnetic eigenmode. My approach activates the excitation of dark modes, while their radiative decay remains suppressed. I will show how to harvest dark modes for surface-enhanced Raman scattering providing superior intensity and an enhancement that is tailored to a specific vibration. Another feature of dark modes is their strong coupling to the vibrations of nanostructures. I will use this to amplify vibrational modes and, ultimately, induce phonon lasing. The proposed research aims at an enabling technology that unlocks a novel range of nanoplasmonic properties. It will put dark plasmons on par with the well-recognized bright modes to be used in fundamental science and for applications in analytics, optoelectronic, and nanoimaging.

Keywords: plasmon,dark plasmon,nanoplasmonics,raman scattering,surface enhanced raman scattering,sers,graphene,carbon nanotubes,molecules,cylindrical vector beams,polarization,phonon amplification
NEUROBIOLOGY OF EPILEPSY GENES (EPITOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 1998760.0
EU funding (EUR): 1998760.0
Participants: 1
Project status: SIGNED

Ion channel genes have long been linked to Mendelian focal epilepsies, but my recent finding of frequent mutations in DEPDC5 opens completely new perspectives. DEPDC5 is an inhibitor of the mTORC1 (mammalian target of rapamycin) signaling pathway, the master regulator of cell proliferation and growth. Mutations of this gene are found in a wide spectrum of focal epilepsy syndromes, with or without cortical malformations. I propose to examine the links between DEPDC5 and the mTORC1 pathway in cortical development and the genesis of epileptic activity. My proposal work will combine high-throughput sequencing, in vivo proteomics, biochemistry, electrophysiology, and animal behavior testing (video-EEG). Functional analyses will be made on human postoperative tissue and neuronal cultures from human iPSC and specific rodent models. These approaches will enable me to (1) ask if and how the mTORC1 signaling pathway may contribute to epileptogenesis and seizures in patients with DEPDC5 mutations, (2) attempt to explain the diversity of phenotypes, in particular the presence of cortical lesion by searching for somatic brain mutations in the gene, (3) explore neurobiology pathways and partners of DEPDC5, and (4) identify novel actors for inherited focal epilepsies. Our results will help us understand the genesis of epileptic networks, and more generally how defects in mTORC1 signaling cascade cause neurologic conditions. We anticipate genetic studies on germline and somatic mutations will have a significant clinical impact for genetic counseling and improved prognosis. The molecules and pathways that will be studied in this proposal differ completely from ion channels and receptors that have been so far associated with focal epilepsies. Thus I hope to provide a new orientation for the field, to identify novel genetic mechanisms and to provide an unbiased route to new molecular therapeutic targets.

Keywords: epilepsy,mtor pathway,next generation sequencing,genetically modified mice models
Plant resilience and floral adaptation to pollinator change during a range expansion (FLORADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Interactions among plants and floral visitors determine the outcome of many important processes, such as pollination, plant reproductive success and, in the longer term, plant evolution. Recent evidence shows human-induced pollinator declines and in consequence plants are experiencing new “pollinator environments”. These changes can be detrimental to plant populations, or alternatively, they could be resilient by adapting to the new environments. This project will use a multidisciplinary combination of field studies and genome sequencing to investigate the resilience and potential for evolutionary change of plant populations when faced with changes in pollinators. For this I will use the recent large-scale range expansion of a European insect-pollinated herb, Digitalis purpurea, as a natural experiment to compare pollinators, floral traits, and estimates of heritability in native versus naturalised populations in the New World. The naturalised populations are pollinated by different animals, and could harbour lower genetic variation. Dense molecular marker panels will be used to estimate heritability in the field. The results will provide important insight into 1) the evolution of plant traits in conditions that could favour innovative change, and 2) the consequences of human-induced environmental changes on plant and pollinator populations in the long term. The main novelty is the combination of the study of changed natural selection regimes with the estimation of trait heritability in the same wild populations. This project will increase my competitiveness for academic consolidation through training a critical period in my career. Working at the University of Sussex will provide excellent training in insect evolution and conservation, bioinformatics, and teaching and mentoring students in a top-class research environment. In turn, I will contribute my knowledge on plant biology through teaching and collaborations in a mostly animal-oriented group.

Keywords: plant pollinator interactions,pollinator declines,genomics,heritablity
Large scale structure of the Universe and fundamental physics (NLO-CO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-11-01
End date: 2020-10-31
Duration (months): 36.0
Total project cost (EUR): 264668.4
EU funding (EUR): 264668.4
Participants: 2
Project status: CLOSED

The purpose of this cosmology project is to study the content and evolution of our Universe using the distribution of matter on large scales. A key goal of forthcoming galaxy surveys is probing fundamental physics, such as the mass of neutrinos and the nature of dark energy, the component sourcing cosmic acceleration. The analysis and interpretation of their data crucially relies on the development of perturbation theory methods and other theoretical tools to describe and predict the evolution of large scale structures in the universe, particularly in the non-linear regime. This project aims to establish the optimal approach to compute the growth of structures and to extract information about dark energy and neutrino masses from the data. This action will address important questions in non-linear structure formation. More specifically, I will 1) devise efficient techniques to obtain information on non-linear clustering from data and apply it to bispectrum estimators and BAO reconstruction; 2) obtain the predictions for general massive neutrinos and dark energy models, beyond the power spectrum; and 3) improve the precision of semi-analytical methods to compute non-linear perturbations on small scales; A very concrete goal of the project is to produce a numerical code and make it public. This code will find direct application in the forecast and analysis of the data from the Euclid mission and other galaxy surveys, to probe the properties of neutrinos and the nature of gravity. In the outgoing phase I will work at University of California, Berkeley (US) to benefit from its great involvement in galaxy surveys and expertise in studies of large scale structure in connection to observations. In the return phase I will work in the Institut de Physique Théorique Saclay (France) where many theoretical developments in perturbation theory and extensions to non-standard models have been developed.

Keywords: cosmology,dark energy,modified gravity,perturbation theory,non linear effects,large scale structure of the universe,galaxy surveys,bispectrum,gravitation