Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SmarT sub-pixel URban flood Mapping from open earth observation and crowdsourcing (STURM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Luxembourg
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-12
End date: 2025-06-11
Duration (months): 24.0
Total project cost (EUR): 262974.29
EU funding (EUR): 184082.0
Participants: 1
Project status: CLOSED

Floods are major natural disasters with severe impacts in urban areas, where increasingly high population density and infrastructure together with worsening climate change trends exacerbate the risk. Reliable and timely monitoring is critical for resilience in terms of pre-disaster preparedness, emergency response, and post-disaster relief. Remote Sensing accurately evaluates flood extent, but data can be expensive and inaccessible. Open RS represents a not fully exploited potential limited by the relatively coarse resolution. Moreover, recent advances in computer vision techniques based on deep learning (DL) and novel observational opportunities can provide valuable information on both flood extent and depth in combination with RS. STURM aims to advance urban flood knowledge by combining open RS Sentinel imagery and crowdsourcing (semantic and visual data) using DL with the ambition of overcoming the constraints of spatial resolution and limited information. STURM leverages free and newly available opportunistic observing systems providing a globally consistent, open-source-based, smart method for improved multi-source observations of hydroclimatic hazardous events in urban areas. The research objectives are to assess and accurately map urban flood extent and depth with enhanced spatial resolution (sub-pixel mapping and measurements from street-level images) and validate the methodology against real disaster events. STURM’s novel data fusion paradigm suits the demand to fill data and knowledge gaps at the urban scale while offering a benchmark solution for hydrological model validation. The DL-based pipeline combines the strengths of globally available data sources while reducing human and economic resource consumption. Global applicability, low cost, and immediate usability are methodological pillars of the STURM project that determine its high impact potential to enhance urban flood resilience and face the global hydrological challenges of the 2030s and beyond.

Keywords: urban flood,deep learning,computer vision
Kinase Regulation by Phase Separation (PhaseKin)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2499943.0
EU funding (EUR): 2499943.0
Participants: 1
Project status: SIGNED

Protein phosphorylation is a process that activates biological and cellular pathways. This process is carried out by enzymes called protein kinases that add phosphates to proteins. Protein kinases are crucial drug targets involved in the onset and progression of human diseases such as cancer and Alzheimer’s disease. Growing evidence suggests that protein kinases are regulated spatially and temporally by the phase separation and condensation of biomolecules into cellular organelles that are not surrounded by membranes. The molecular mechanisms that govern the action of kinases in phase-separated condensates, however, are unknown. Knowledge of these mechanisms is crucial for the development of better drugs that target protein kinases. To address this challenge, I have designed an interdisciplinary project that goes well beyond the state-of-the-art to explore in atomic detail the action of protein kinases intimately involved in Alzheimer’s disease and the abnormal phosphorylation of the protein Tau. The PhaseKin project aims to (i) reveal the specificity and reaction kinetics of protein kinases inside phase-separated condensates in vitro and in cells, (ii) decipher the dynamic conformational landscape of the protein kinases MARK2 and GSK3β by advanced NMR methods that will grant unprecedented detail on their modes of regulation, (iii) disentangle changes in population distributions and rates of interconversion between structurally distinct kinase states inside condensates, (iv) unravel the physicochemical basis of kinase drug partitioning into condensates. The highly innovative nature of the project is devised to delve into the heart of protein kinase function and to revolutionize our knowledge about the chemistry of drug-kinase interactions. Findings from the PhaseKin project will provide critical guidance in the development of more efficacious and specific drugs which target protein kinases.
Subject or Object? SINo-American competition and European sTRAtegic autonomy (SINATRA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1726250.0
EU funding (EUR): 1726250.0
Participants: 1
Project status: SIGNED

The intensifying great power competition between the United States and China has arguably become the structuring vector in international politics. This project examines to what extent the European Union (EU) is able to autonomously make decisions regarding its relations with the United States and China. The key innovation is to present a comprehensive theory to explain to what extent and under what circumstances external or internal actors have the upper hand in informing European policy choices in Sino-American competition. Assuming the existence of a correlation between the EU’s (degree of) unity and autonomy, the latter is depicted as a relative and contingent concept. The main hypothesis is that the EU’s degree of autonomy vis-à-vis China and the United States will be high in those policy areas where it enjoys exclusive competences, moderate where it has shared competences, and low where the competences rest with the member states. I expect this to happen despite the high degree of “issue linkage” (Haas, 1980; McGinnis, 1986) between the different areas of EU external policy; despite the fact that the United States and China will try to exploit Europe’s dependence in some areas to extract concessions in others; and despite the fact that the EU itself will try to build on its competences in some areas (e.g. trade) to expand its clout in others (e.g. foreign and security policy). SINATRA pushes back against the conventional wisdom that the EU is either poised to become an autonomous subject or condemned to the status of mere object or battleground in Sino-American competition, by arguing that the EU will be subject and object at the same time, and unpacking the mechanics of that tension. The project draws on mixed methods research, combining quantitative analysis of European, American and Chinese voting patterns and public discourse (i.e. through the use of content analysis software and manual coding) in a variety of international organisations and debates

Keywords: european strategic autonomy great power competition transatlantic relations
Structural basis for membrane protein biogenesis at the Endoplasmic reticulum by the SND pathway (StructureSND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

One-third of eukaryotic genes encode for integral membrane proteins (IMPs) with the majority being assembled at the endoplasmic reticulum (ER) after being translated by the ribosome. The SRP-independent (SND) targeting pathway was recently identified as a new route for ER targeting and insertion of IMPs. It was found to recognise a subset of IMPs with a central transmembrane domain, yet it also serves as an alternative route to deliver a broad range of substrates to the ER when their canonical pathways are impaired. The yeast SND pathway comprises three components, SND1, SND2 and SND3. The cytosolic SND1 is a putative ribosome-associated factor and receptor for nascent IMP substrates. SND2 and SND3 are proposed to form a heterodimeric complex at the ER membrane that, together with the SEC61 translocon, mediates membrane insertion of substrates. However, direct evidence for the roles of the SND components and their physical interactions with each other and complexes such as the ribosome and the SEC61 translocon is lacking. This project aims to elucidate the molecular interplays between SND components and other targeting and insertion factors using a combination of structural biology, biophysics, and biochemistry. First, I will establish a genomic tagging system to purify SND complexes from Chaetomium thermophilum. I will integrate mass spectrometry and different biophysical tools to identify and subsequently characterise the interactions between SND components and their associated proteins involved in ER membrane targeting and insertion, or potentially other novel biological functions. Ultimately, I will solve the structures of endogenous SND complexes by cryo-electron microscopy. This work will provide comprehensive insights into how the SND complexes capture a broad range of substrates and execute their ER membrane targeting and insertion, and will thus have far-reaching impacts on our current understanding of membrane protein biology.

Keywords: membrane protein biogenesis,er targeting and insertion,the snd pathway,cryo em,chaetomium thermophilum
Reassessing Late Medieval Pharmacology: Logical and Metaphysical Tools in the Medical Context (ReMedY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1498828.0
EU funding (EUR): 1498828.0
Participants: 1
Project status: SIGNED

ReMedY addresses the metaphysical, logical and epistemological implications of late medieval pharmacological classifications. Medieval pharmacology was often divided into a rational and a practical part. Rational pharmacology dealt with the theories of drug classification, explaining how to recognise the substance and the qualities of a drug and how to differentiate it from other drugs. Rational pharmacology was thoroughly re-systematised during the 14th century in various university milieus, having been influenced by scholastic philosophy. It is generally acknowledged that the faculty of medicine at Bologna played a central role in this process, due to its strong connection with the philosophical tradition. It is clear that some Bolognese masters were influenced by French modism, which based logic on ontology, dividing reality into the three 'modi' of being, knowledge and meaning. Yet, it has never been investigated how this philosophical debate has influenced rational pharmacology or how it has provided it with indispensable theoretical tools. And this is exactly where this project comes into the picture: ReMedY’s unconventional and cross-disciplinary approach connects modist doctrines and pharmacological theories, providing an innovative interpretative key regarding the correlation between rational pharmacology and philosophy during the Middle Ages. The hypothesis of the project, namely that modist theories influenced a distinct tradition of late medieval rational pharmacology is entirely original. My team and I will link research fields that have been kept apart, but whose organic connections provide a new perspective on medieval philosophy. Combining philological, editorial, historical and epistemological approaches, the ReMedY team will deal with pharmacological texts from different geographical areas and provide access to previously unedited sources of historical scientifical value through critical (and digital) editions and doctrinal studies.

Keywords: history of medieval medicine history of medieval pharmacology digital approaches to philosophy
A Micromotor-driven Triboelectric Nanogenerator with different Propulsion mechanisms (MMTENG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: CLOSED

The triboelectric effect is always considered a negative phenomenon in daily life, and this perception was altered when the first triboelectric nanogenerator (TENG) was proposed in 2012 as a new energy source. To date, the TENGs are well developed by thousands of researchers across the world, utilizing human activities, water waves, wind, and rain drops. However, there is still a gap between triboelectricity and other energy sources, for example, chemical energy and light. Inspired from natural immunocytes, artificial micromotors (MMs) referred to microscale particles capable of converting different energy sources into kinetic energy were well developed since 2004. The objective of this project is to apply MMs in TENG design (MMTENG) as an alternative strategy for electricity generation, which is expected to build up a bridge between other energy sources and electric energy through triboelectricity. The project will focus on i) the fabrication of the dielectric MM and the motion analysis under required circumstances with different propulsion mechanism; ii) the assembly of a freestanding TENG with metal electrodes and electrifiable polymer membrane; iii) the measurement of the triboelectricity converted from different energy sources. This interdisciplinary project will be supported by i) a world-renowned expert in micro/nanomachines and electrochemistry, Prof. Martin Pumera, as the host, and the facilities at Central European Institute of Technology; ii) colleagues specialized in electrochemistry and triboelectricity; iii) excellent trainings for both scientific skills and soft skills, workshops, and seminars, together with the researcher’s own experiences in MMs. In research aspect, it is always of great importance to develop new energy sources. In career aspect, with the international working environment and the inspiring research topics in the interdisciplinary field, this project will be a boost to the researcher's future academic career.

Keywords: triboelectric nanogenerator,micromotor,electricity generation,triboelectricity
Research and Innovation Strategy for Lviv Polytechnic National University dedicated to White-Emitting Organic Lighting Systems (HELIOS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Chemistry
Countries involved: Ukraine,Lithuania,Luxembourg,United Kingdom,Latvia
Call: Twinning Green Deal (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1237500.0
EU funding (EUR): 1175250.0
Participants: 5
Project status: SIGNED

HELIOS aims to elevate the scientific excellence and innovation capability of Lviv Polytechnic National University (LPNU) and its esteemed Twinning partners - Kauno technologijos universitetas, University of Glasgow, Rīgas Tehniskā universitāte, and Intelligentsia Consultants Sarl. Their research component target is the creation of white-emitting organic systems for lighting. Over three years, they will follow a research and innovation strategy spread across five core objectives and eight work packages. - Objective 1 focuses on exploratory research to design ultra-efficient single-molecular white emitters for WOLEDs and WLEDs, aiming for a significant breakthrough in solid-state lighting cost-performance. - Objective 2 centers on knowledge transfer between experienced researchers from LPNU and its Twinning partners. Activities will involve staff exchanges, trainings, and seminars to reinforce the research from Objective 1. - Objective 3 aims to boost career opportunities for early-stage researchers of both LPNU and the Twinning partners. Methods will include short to medium exchanges, training workshops, summer schools, and a shared PhD programme. - Objective 4 is geared towards refining LPNU's project management skills, specifically in proposal drafting and managing European R&D funding projects. - Objective 5 is committed to elevating the research stature of LPNU and its Twinning partners. They intend to achieve this via widespread dissemination, communication, and outreach initiatives.

Keywords: single molecular white emitters,white light emitting diodes,woleds,down converting light emitting diodes,wleds
Securing Europe’s MARitime domain against threats through vessel-CONNECTed services (MARCONNECT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Border Management
Action type: Research and Innovation actions
Countries involved: Romania,Portugal,Germany,Netherlands,Italy,Greece,Cyprus,Finland
Call: Open Topic (HORIZON-CL3-2024-BM-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 3623928.48
EU funding (EUR): 2979319.69
Participants: 13
Project status: SIGNED

Europe's vast maritime domain faces challenges in situational awareness and border security due to dynamic operations and rising maritime crimes. Current surveillance technologies lack cost-efficient, wide-ranging coverage, leaving gaps in EU monitoring. MARCONNECT introduces the Vessel-Connected Services (VCS), a disruptive solution that transforms civilian vessels into active contributors to a real-time, integrated maritime surveillance network. By securely and voluntarily sharing their outward-looking sensor data (e.g., radar, sonar) with Coast Guard Authorities, civilian vessels become valuable assets in enhancing maritime situational awareness. In return, vessel owners gain access to tailored third-party services of their interest and real-time connectivity, creating a synergetic ecosystem. The main end-users of the VCS solution include Coast Guard Authorities, extending also to law enforcement agencies , who will benefit from a dynamic and scalable maritime security solution, and maritime operators across the EU, while private sector stakeholders benefit from anonymised, aggregated data insights to improve their businesses. The impact of the VCS solution is profound, resulting in a significant expansion of maritime surveillance coverage, strengthened ability to detect and respond to maritime threats, complementing existing maritime intelligence services. MARCONNECT capitalises on the trend of decreasing maritime communication costs, accelerating this shift by enabling broader and affordable access to real-time connectivity. This vision is enabled by an experienced consortium of relevant Coast Guard Authorities and Law Enforcement, key maritime industry players, and leading SMEs and RTOs with a proven track record in border security, uniquely positioned to transform Europe’s maritime security landscape and strengthen its borders

Keywords: vessel connected services civilian vessel integration,maritime iot,maritime situational awareness vessel outward looking sensor data,data privacy,third party services
GLYCOprotein N-glycosylation from non-life to eukaryotes: a Doctoral Network to expand the knowledge on a ubiquitous posttranslational modification of proteins (GLYCO-N)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Netherlands,Spain,Denmark,France,United Kingdom,Germany
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-03-31
Duration (months): 50.0
Total project cost (EUR): 2677118.4
EU funding (EUR): 2677118.4
Participants: 17
Project status: SIGNED

The GLYCO-N training network aims at training Doctoral Candidates (DCs) to acquire the skills to develop different innovative strategies to 1) understand the diversity and structural complexity of archaeal, microalgal and viral N-glycosylation and 2) harness this knowledge for new solutions in biomedicine and biotechnology. Protein N-glycosylation, or the attachment of oligo- and polysaccharides at specific asparagine residues, is conserved throughout life, and is now observed even in the viral world. In contrast to eukaryotes, whose well-studied N-glycosylation machineries are relatively simple, archaea, microalgae and bacteria utilize a wide variety of monosaccharides to create a wealth of structurally diverse N-glycans, and the same holds true for some recently discovered viruses. Because protein glycosylation occurs far downstream of protein synthesis the complexity and diversity in N-glycan structures are poorly understood in detail. This holds true specifically for N-glycosylation events that are the subject of the GLYCO-N program: those in archaea, microalgae and viruses. Understanding of the how and why of N-glycosylation in archaea, microalgae and viruses will open up many possibilities ranging from drug discovery (antivirals) to biotechnology (glycoprotein and glycoprocessing enzyme engineering for materials and life sciences). The GLYCO-N network brings together a diverse group of glycobiology researchers with world-leading expertise in microbiology, (bio)organic chemistry, computational and structural biology, bioinformatics and chemical biology. The GLYCO-N DCs will have their own individual project with one GLYCO-N expert and will, through research internships, be exposed to complementary Glycoscience. All individual PhD projects, while rooted in fundamental science, have a practical application, either in biotechnology or in biomedicine, as will be explored through secondments with our associated partners.

Keywords: n glycans glycoengineering carbohydrate processing enzymes biomedicine biotechnology