Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cognition And Nutrition (CAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 174928.32
EU funding (EUR): 174928.32
Participants: 3
Project status: TERMINATED

Since 2014, cross-section and interventional work at the Nutrition Research Centre Ireland, Waterford Institute of Technology has demonstrated the importance of good nutrition, and the benefits of targeted nutritional supplementation, in optimising the neurocognitive environment. Research at the centre has intensified over the last few years to support a biologically plausible rationale whereby nutritional intervention can positively impact on cognitive outcomes in cognitively healthy and mildly impaired individuals. Importantly, what remains to be fully understood is the specific brain regions and neural networks that are potentially mediated by nutrition. Inspiring new programs of medical research can translate findings from nutritional science into innovative clinical assessment tools, technologies, and therapies to advance the practice of modern medicine. At the frontiers of this path-breaking effort is research within the emerging interdisciplinary field of nutritional cognitive neuroscience (NCN), which was established at the Decision Neuroscience Laboratory, University of Illinois. Using state of the art methodologies and technologies from the fields of nutritional epidemiology and cognitive neuroscience, NCN aims to advance our understanding of the beneficial effects of nutrition on the ageing brain. The Cognition And Nutrition (CAN) project will generate new knowledge within the NCN field to better understand the ways in which aspects of brain structure and function can be supported by particular nutrients and dietary patterns. In addition, CAN will stimulate interdisciplinary collaboration and bi-directional transfer of knowledge between both centres. Ultimately, this work will have profound implications for understanding healthy brain aging and for treating age-related neurological disease, as well as improving the precision of nutritional interventions that will inform future research practices and public policy.
An Antibody Microarray for Histone Modifications (HisMoDetect)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-10-01
End date: 2017-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Histones are the major structural proteins of eukaryotic DNA. Two copies each of the core histones, H2A, H2B, H3 and H4, form the core nucleosome, the basic unit of chromatin. Histone tails protrude from the nucleosome structure and are subject to a variety of post-translational modifications on multiple residues, including methylation, acetylation, phosphorylation, sumoylation, ubiquitination and polyribosylation. These histone modifications dictate local and global structure of chromatin, rendering it active and decondensed (‘euchromatic’) or suppressed and compact (‘heterochromatic’) by the recruitment of chromatin-binding proteins that recognize and associate with specific modifications. Histone modifications are therefore the basic regulatory unit of gene expression, genomic silencing, developmental programs, cell division and essentially all cellular processes. Understanding this so-called ‘epigenetic’ landscape is therefore vital for all biological mechanisms. Currently a Western blot is required in order to determine the state of each of the dozens of different histone modifications. Because of the growing number of histone modifications, this procedure is time consuming and labour intensive. Here I suggest to develop an antibody microarray to monitor the levels of all histone modifications simultaneously. This method will be essentially useful for any tissue or cell type in any biological process, for diagnosis, prognosis and drug screening. In addition to basic research, our platform will enable fast and reliable screening for epigenetic effects of existing and novel drugs. We believe that such a product could serve many drug companies interested in direct and indirect effects of epigenetic and non-epigentic drugs.

Keywords: chromatin,antibody,microarray,histone,modifications,epigenetics
Feasibility study for the validation and industrialization of two diagnostic kits in both ELISA and CLIA formats for the early detection of pancreatic cancer based on the novel biomarkers EZR and ENOA (EDePDAC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Italy
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In this study we propose to investigate the feasibility of the industrial development and validation up to the CE marking of two immunodiagnostic kits based on two novel biomarkers recently identified as specific markers of early stage pancreatic cancer, Ezrin (EZR), and its treatment follow up, phosphorilated alpha-Enolase isoforms 1,2 (ENOA). The assays will detect antibodies to these biomarkers in blood. Pancreatic Ductal AdenoCarcinoma (PDAC) early detection is an unmet medical need in the developed world. Presently this cancer is the fourth leading cause of cancer-related death. The EZR kit, used alone on people at risk for PDAC, is proposed as a tool for an early diagnosis of pancreatic cancer. Blood positivity to both antibodies against EZR and ENOA is of great importance for a correct diagnosis of PDAC and the assessment of its development stage. Finally, the combined use of blood test for Ab-EZR, Ab-ENOA and CA19.9 should provides a robust tool for the general diagnosis of PDAC (100.0% sensitivity and 93.7% specificity). Te study will be conducted together with an expert and well introduced company in the field of IVD having a consolidated distribution network, that will support NatiMab in the assessment of the industrialization process and the market entering, and two companies which have the technical capabilities for the production of the two key components: EZR (GeNeuro) and ENOA (Iris Biotech). The IVD segment for PDAC early diagnosis and therapeutic assessment, including screening of population at risk, is a 3 billion potential market. NatiMab has the ambition to become a key player and first mover in such huge market. The final technological target of Natimab project is the development of a three-marker panel, including EZR, ENOA and CA19.9, which is expected to greatly reduce the need for invasive diagnostic screening. The deliverable of the study will be a feasibility report including a detailed business plan.

Keywords: pancreatic cancer,early diagnosis,elisa,clia
Isolation of rare circulating tumor cells (CTC-MAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-02-01
End date: 2019-01-31
Duration (months): 12.0
Total project cost (EUR): 149375.0
EU funding (EUR): 149375.0
Participants: 1
Project status: CLOSED

In 2013 I was awarded an ERC consolidator grant to pursue a novel cancer targeting concept using a recombinant malaria protein. As an ERC grantee I verified the malaria protein (rVAR2) binds to this distinct cancer expressed molecule (CSA) in hundreds of cancer cell lines and thousands of tissue biopsies. Our research demonstrate a pivotal role of CSA in cancer cell migration and thus in the formation of metastasis. Circulating tumor cells (CTCs) are cancer cells escaping the primary tumor with the capacity to settle and form a metastasis in distant organs. Isolation of CTC is thus a very attractive non-invasive measure of the stage of a given cancer and provides the opportunity to do direct phenotypic analyses. However CTCs are in most cases very rare (10 cells pr 1ml blood) and does not uniformly distinguish themselves from normal blood cells. Our preliminary data show that rVAR2 very effectively can be used to isolate CTCs from diverse types of cancer with unprecedented specificity and sensitivity. Such a tool could have wide impact for cancer patients because it could sharpen diagnosis, increase prognostic ability, monitor drug efficacy and facilitate molecular characterization of individual cancers with implications for personalized medicine and basic cancer research. The aim of the ERC PoC project is to A) prepare for establishment of a separate company with a strategic product plan and B) further develop and validate the methodology enabling diagnosis, prognosis and guide treatment.

Keywords: cancer,circulating tumor cells,liquid diagnostics,diagnostic
Network Solution for Exascale Architectures (RED-SEA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EuroHPC (Art-187)
Countries involved: Spain,Spain,Germany,Italy,Germany,Germany,Italy,Switzerland,Greece,Greece,France,France
Call: Extreme scale computing and data driven technologies (H2020-JTI-EuroHPC-2019-1, 2019)
Start date: 2021-04-01
End date: 2024-03-31
Duration (months): 36.0
Total project cost (EUR): 7993710.0
EU funding (EUR): 3996855.01
Participants: 12
Project status: SIGNED

In order to enable Exascale computing, next generation interconnection networks must scale to hundreds of thousands of nodes, and must provide features to also allow the HPC, HPDA, and AI applications to reach Exascale, while benefiting from new hardware and software trends. To achieve this goal, the RED-SEA proposal gathers the key European R&D competences, by bringing together the top academic centres with the key European industrial forces in this domain. The project will leverage BXI, the key European Interconnect, which is in production and featured in Top 500 systems, with the aim to adapt it to the challenges of coming years. RED-SEA will pave the way to the next generation of European Exascale interconnects, including the next generation of BXI, as follows: i. specify the new architecture using hardware-software co-design and a set of applications representative of the new terrain of converging HPC, HPDA, and AI; ii. test, evaluate, and/or implement the new architectural features at multiple levels, according to the nature of each of them, ranging from mathematical analysis and modelling, to simulation, or to emulation or implementation on FPGA testbeds; iii. enable seamless communication within and between resource clusters, and therefore development of a high-performance low latency gateway, bridging seamlessly with Ethernet; iv. add efficient network resource management, thus improving congestion resiliency, virtualization, adaptive routing, collective operations; v. open the interconnect to new kinds of applications and hardware, with enhancements for end-to-end network services – from programming models to reliability, security, low-latency, and new processors; vi. leverage open standards and compatible APIs to develop innovative reusable libraries and Fabrics management solutions. We will work together with the other projects resulting from the EuroHPC-01-2019 call, especially with IO-SEA (topic b) and DEEP-SEA (topic d) if they get approved.

Keywords: interconnect network
Development of BMP2 Neurotrophic Therapy for Parkinson’s Disease (BMPARK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: CLOSED

Parkinson’s Disease (PD) is a progressive neurodegenerative disease. PD affects more than 6 million people worldwide while 1.2 million people have PD in Europe. For the European economy PD has a total socioeconomic cost of €13.9 billion per annum. With the aging demographic the number of individuals affects by PD are projected to double by 2030 highlight the need for disease modifying therapies. The neuropathological hallmarks of PD are the progressive loss of dopaminergic neurons in a region of the brain known as the substantia nigra in the midbrain, and the accumulation of intraneuronal inclusions called Lewy bodies and lewy neurite that consist predominantly of a protein called α-synuclein. Despite over half a century of investigation, there is no disease modifying therapy for PD. I propose that a protein called bone morphogenetic protein (BMP)2 can protect midbrain dopaminergic neurons in the PD brain. BMP2 is distinct from other neurotrophic factors used in the clinical trials to date in that it has a different signalling mechanism that can be targeted to protect dopaminergic neurons. Here I will assess the neuroprotective efficacy of viral vectors carrying the BMP2 transgene in the rat α-synuclein model of PD. I will determine if this molecular therapy can protect dopamine neurons and their axons against α-synuclein induced degeneration to maintain brain dopamine levels and improve motor function. To do this, I will use a multidisciplinary approach which will be paralleled by intensive training and career development opportunities to enable me to make a transformative contribution to knowledge and to achieve professional maturity and independence. In this way, this work has direct relevance for the future development of neurotrophic factors for clinical use in PD and the extensive dissemination and communication plans to target all stakeholders will ensure both societal and scientific impact in an European context and also for individuals with PD.

Keywords: neurotrophic factors,parkinson s disease,alpha synuclein,neurite growth,bone morphogenetic protein
Quantum Metrology Electrical Triangle (QMET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

The standard definition of the Ampere can be obtained exploiting the dual counterpart of the Josephson effect, namely voltage Bloch Oscillations (vBO). A way to measure them consists in embedding a largely non-linear Josephson junction in a high impedance environment, irradiate it with a microwave pump, and observe discrete DC current steps. The QMET (Quantum Metrology Electrical Triangle) action tackles this objective by leveraging the researcher demonstrated ability of performing precision microwave measurements devising novel apparatuses and the mastering of the host group in the design and fabrication of high-impedance superconducting circuits. Such result would provide a leap in quantum metrology and paves the way to the redefinition of the ampere using only fundamental constants.

Keywords: metrology
BUSINESS INTELLIGENCE RETAIL DATA (BIRD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Greece
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Intale is an early stage high risk innovative SMEs in the ICT sector, applying new sets of rules, values and models which optimize the way in which key stake holders in the fragmented sales channel do business. Intale, formerly known as i-kiosk in the Greek market, was initially named after its award-winning cloud-based PoS product for small retail shops. Intale has currently reached a critical-mass of users in Greece, evolving into a small-scale ERP and is installed in 400 points in Greece, accounting for 40 million annual transactions worth €150 million. Intale aims to disrupt small retail market forever, unifying the whole value chain. It offers store owners an easy-to-use PoS software that replaces outdated, inefficient cashier systems and streamlines daily operations to improve efficiency. Meanwhile, it provides market research firms with a convenient source of consolidated sales data from this previously fragmented PoS network, and consumer brands with access to real-time sales data and analysis from individual PoS to improve sales and marketing efforts. Ultimately, Intale enables the end consumers to extract more value from their local stores with promotional offers from their favourite brands, as well as convenient e-payment services. BIRD project is positioned to maximize initial traction and market momentum of i-kiosk and lead the next phase of development for the company. Currently, Intale employs 10 people, has already received 325,000 euros funding from Greek VC EIF Partners and has secured a second seed round of 450,000 euros. During Phase 1, it will elaborate a business plan that leverages its current technology and user-base, providing a dual Product & Data-as-a-Service business model. Thus, using Greece as a solid proof of concept, Intale envisions fast market-uptake (six international markets in 2016) and lead in the landscape of small retail worldwide, achieving a valuation of over €120 million by 2019 and employing more than 50 staff.

Keywords: big data,predictive analytics,supply chain optimisation,retail software
Novel low-cost ground penetrating radar system for safe, simple and swift detection of all utilities piping and cabling located underground (e-Safe)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2015-11-01
End date: 2016-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Across Europe and the world, the installation of underground utility services continues to grow. The ground beneath Europe’s cities streets, which already contains a myriad of pipelines and cables, is rapidly becoming over congested. For example, the city of Rome’s 3million inhabitants are serviced by 65,000km of buried pipes and cables. Due to this congestion, delivery of vital utilities through the installation and maintenance of new and existing underground services is becoming increasingly difficult and dangerous. The personnel working in the various utilities sectors (telecoms, water, gas, electricity etc.) face daily challenges with regard safe excavation for installation and maintenance. With limited utility detection solutions available on the market and the general absence of accurate underground piping and cabling records, accidents and damage to these utilities is occurring on a large scale. Maintenance contractors are causing 90,000 incidences of third party damage to EU gas pipelines alone annually. In a North American study, it was found that 25% of incidences are due to insufficient locating practice. The impact of such damage is wide-ranging; approximately 120 deaths and 6,000 serious injuries are attributed to contact with the electricity network occur in Europe every year, while repair costs for damaged services can run into many millions of euros. The above problem demands urgent action. There is a clear need for a cost effective, rapid, compact, high performance “all services avoidance” solution that ensures the safety of utilities maintenance personnel, prevents utilities damage, and speeds up location of safe excavation zones. PipeHawk Plc has developed a totally unique system (e-Safe) that addresses all these needs. Our innovation project will bring the e-Safe system, currently at TRL6, to market readiness. We expect to capture up to 5% of the global market, generate annual profits of €16.4million, & create 70 new jobs by yr 5 post project.

Keywords: ground penetrating radar,smart cities,underground utilities,electrical energy networks,communication networks,water services,accidental damage,health and safety
Why is Business in Some Countries More Hostile to Social Redistribution than in Others? (BUSWEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Can differences in the attitudes and organization of business interests explain differences in the politics of social redistribution across countries? Since the 1970s, Europe and the United States have diverged in terms of how taxation and welfare policies ameliorate income inequality: In the United States, far-reaching policy changes have produced a substantial rise in income inequality, while income inequality in many European countries has increased to a much lesser extent. BUSWEL analyzes how the strategies and activities of business interest groups have contributed to these diverging outcomes. The project compares policy positions and strategies of business interest groups in five countries: Denmark, Sweden, Germany, Austria, and the United States. These five countries have been selected because of their different policies of redistribution and different levels of inequality. The project focuses on three policy issues that are assumed to have an effect on social redistribution: corporate tax cuts, payroll tax cuts and deregulation of employment protection. The project aims to document differences in policy positions of business interest groups in these fields across countries and to identify the impact of these differences on the differing trajectories of policy change across countries. The project bridges theoretical perspectives from sociology, political science, and history. The insights gained from this project on the political goals and strategies of business interest groups will be useful for national and European policy-makers confronting demands by business representatives. The project will be carried out at the Center for Welfare State Research at the University of Southern Denmark, a major center for research and expertise on welfare state politics and political economy. (1554 characters)

Keywords: welfare state institutions,business and politics,comparative political economy,social policy,tax policy,labor market policy