Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Boosting stress resilience of Arabidopsis by heterologous expression of a selenocysteine containing glutathione peroxidase (RedoxBoost)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: SIGNED

Various environmental stress conditions in plants lead to oxidative stress and trigger damage to macromolecules causing losses in the crop yield. To better cope with oxidative stress via boosting the redox potential, and antioxidant activity, the RedoxBoost project aims to ectopically express the selenoprotein glutathione peroxidase from Chlamydomonas reinhardtii (Sec-CrGPX) in Arabidopsis thaliana. Selenoproteins entail a selenocysteine (Sec) amino acid, encoded by the UGA, which encodes stop codon in higher plants. Thereby, selenoproteins are not present in higher plants but present in eubacteria, archaea, and eukaryotes including green algae. Most of the known selenoproteins were involved in antioxidant activity, redox regulation and are more resistant to irreversible oxidation under severe oxidative stress than their cysteine homologs. I hypothesize that heterologous expression of selenoproteins in higher plants might offer an excellent opportunity for harnessing plants against oxidative stress and hence develop more stress resilient plants. Glutathione peroxidase is one of the most abundant selenoproteins and known to protect cells from oxidative damage. To achieve heterologous expression of Sec-CrGPX in Arabidopsis, initially a DNA assembly of whole Sec biosynthetic pathway and Sec-CrGPX will be transiently expressed in Nicotiana benthamiana to get a swift assessment on the feasibility of ectopic Sec-CrGPX expression in land plants. Then, these Sec-CrGPX DNA assemblies will be stably transformed in Arabidopsis. RedoxBoost for the first-time will integrate the coding mechanism for Sec in higher plants. Biochemical and physiological studies will be performed in transgenic Arabidopsis plants under different stress conditions to determine altered stress resilience. In a changing environment where flooding, waterlogging conditions, and saline soils are becoming more frequent RedoxBoost presents a novel approach for development of stress resilient plants.

Keywords: selenoprotein,selenocysteine,antioxidant,redox regulation,arabidopsis,
Digital-Twins for Hydrogen and Ammonia injection and ignition in engines for Transport Systems (DT-HATS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United Kingdom,France,Germany,Belgium,Austria,United States,Switzerland,Saudi Arabia
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 4903405.92
EU funding (EUR): 4658251.32
Participants: 18
Project status: SIGNED

DT-HATS focuses on the decarbonization of the heavy-duty transport sector – which is currently responsible for over 50% of the sector CO2 emissions – by exploiting the combination of green hydrogen and ammonia with their technical and economic potentials. The project will offer a systematic training to the recruited doctoral candidates who will produce new knowledge in ammonia and hydrogen flow and reacting processes realized in powertrains used for transport and efficient utilization in the H2 ecosystems. The overall aim is to: research H2 and NH₃ as fuels from a fundamental level to build a detailed database; develop new validated CFD models specific for H2 and NH₃, enhanced with ML for faster, predictive design; create reduced-order models based on multi-fidelity CFD-ML data and experiments for efficient exploration of H2 and NH₃ ecosystems, from component level like injectors to system level like engines, to aid decarbonization in transport sectors. Ultimately, DT-HATS through its research and training programs at the intersection of energy engineering and computational science will strength digital skills and expertise of young scientists and entrepreneurs to tackle present and future challenges and will also promote green e-fuels adoption in transport, boosting renewable energy growth.

Keywords: hydrogen,ammonia,heavy duty transportation,multi fidelity models,computational fluid dynamics,injection,combustion,digital twins
Secured SATCOM-based solution enhancing emergency services and search & rescue missions – SAT2Rescue (SAT2Rescue)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Innovation actions
Countries involved: Poland,Austria,Slovakia,Greece
Call: EU GOVSATCOM for a safer and more secure EU (HORIZON-EUSPA-2023-SPACE, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 4300000.0
EU funding (EUR): 3587500.0
Participants: 7
Project status: SIGNED

The aim of the SAT2Rescue project is to strengthen the use of satellite communication by government institutions and non-governmental organizations, in particular in the areas of response to natural and man-made disasters, optimization of emergency services activities, and telemedicine in humanitarian aid. Infrastructure and services under the GOVSATCOM initiative will be used. As part of the project, a telecommunications satellite terminal will be built, which: • It is portable and mobile: compact dimensions, flat electronic antenna and rugged, durable form allow it to fit in a vehicle, boat or carry in a backpack. • It allows you to establish reliable communication (voice and data transmission), even in the absence of a cellular network signal or outside the range of a terrestrial radio communication system. • It is fully automatic: when turned on, it locates itself using GNSS (including Galileo), locks on to a satellite (in both geostationary and low Earth orbit) and controls the antenna to track it. It can also dynamically switch between satellites without interrupting the connection • Enables you to establish and maintain a connection even while on the move (e.g. while driving) • It is resistant to GNSS signal jamming and spoofing • Provides the ability to divide a single satellite communication channel into independent virtual networks (Software Defined Networking) Usage scenarios will be defined, including: mountain and sea rescue and rescue operations in urbanized areas after disasters. Application software will be developed for rescue operations management centers, providing a situational picture of the operation, integrating geoinformation and weather data, image data from the Copernicus system, and geotag data collected via the Galileo system. The system will be demonstrated according to usage scenarios.
CURE HEARTandBRAIN postdoctoral COFUND programme by CNIC (CURE HEARTandBRAIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Denmark,United States,Italy,United Kingdom,Germany,Sweden,Netherlands
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1719360.0
EU funding (EUR): 1719360.0
Participants: 26
Project status: SIGNED

The CNIC (Spanish Centre for Cardiovascular Research) is a worldwide recognised research centre dedicated to cardiovascular research. CNIC’s mission is to improve cardiovascular health in the society by generating scientific knowledge, efficiently translating that knowledge to the clinic, and providing new researchers with a comprehensive training. CNIC, awarded with the HR Excellence in Research since 2013, proposes to run a postdoctoral fellowship programme “CURE HEART & BRAIN” that will offer a total of 12 positions in the incoming mobility type for the selected and eligible candidates (holding PhD and compliant with MSCA mobility rules). During the COFUND grant life (5 years) there will be two calls (M2 and M9), each offering 6 fellowships. The Programme will advertise the positions internationally. The fellows will be able to choose the supervisor at CNIC and to propose research projects in all the research disciplines available at CNIC. The selection of the proposals will be transparent, based on merit and performed by external international peer-reviewers. CURE HEART & BRAIN fellowship programme will be open to excellent researchers of any nationality. The programme will offer training to develop key transferable skills and competences, foster innovation, entrepreneurship, promote Open Science practices, FAIR data management, and public engagement. The fellows will acquire new skills through advanced training, international, interdisciplinary and inter-sectoral mobility. CURE HEART & BRAIN includes 24 Associated Partners (12 from private sector) from all over the world and from different sectors, providing translational elements to the programme (secondments, training, supervision). The overall goal of the programme is to enhance the creative and innovative potential of a new generation of translational researchers in cardiovascular research and related areas as well as reach out to society to make the results of the research visible to the citizens.

Keywords: training,cardiovascular disease,innovation,postdoctoral training,equal rights opportunities
Creatures of Sorrow: Lay experiences of melancholy in early modern Scandinavia (CROW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

CROW explores lay experiences of being mentally unwell in 16th- and 17th century Scandinavia. It asks how social status, gender and age affected experiences of mental states before the modern era. In doing so, it deepens our understanding of mental suffering historically and creates an inclusive and complex history of the phenomenon. The project uses new sources and new digital methods that combined can reach a wide variety of experiences. The objectives of CROW are: 1. Provide an examination of experiences of being mentally unwell in the early modern period that takes into account embodied experiences and emotions as well as early modern religious and medical frameworks; 2. Advance the scope for examining lay people’s experiences through the use of digital methods; 3. Provide a historical account of experiences of mental suffering that informs present-day debate about mental health. CROW uses as a point of departure the understanding that experiences are created through embodied sensations in cultural contexts, and thus socially bound and historically significant, to argue that they can be researched through patterns in individual statements regarding embodiment, in tandem with reconstruction of cultural frameworks. The project examines ecclesiastical court records from the Scandinavian realms to find patterns in verbatim text concerning embodied sensations. These patterns are examined in relation to descriptions of melancholy in religious and medical vernacular texts aimed at a lay audience. Through the use of software in several steps, the examination moves from the concept of melancholy, which is key to understanding mental suffering in the early modern, learned debate, to the descriptions of embodiment, which means that experiences of mental suffering can be found even when the concept of melancholy is absent. In addition to advancing understanding of early modern mental suffering, this approach will contribute theoretically to the history of experience.

Keywords: history of experience,history of emotions,mental suffering,early modern
Development of Innovative Tools for OPtimal management of Recirculating Aquaculture Systems (iTOP-RAS)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Portugal
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Aquaculture is the world’s fastest-growing agri-tech sector. To support that growth, the industry needs to find innovative solutions to challenges, such as sustainability, disease, lack of space for expansion, and freshwater availability. Recirculating aquaculture systems (RAS) have been the answer to those problems; these land-based fish farming systems are designed to control culture conditions for intensive farming, while increasing biosecurity levels, minimizing water consumption, and managing waste streams. However, their water monitoring systems lack real-time sensors to quantify the highly toxic compounds ammonia, nitrite, and nitrate, which can accumulate in closed systems and cause the sudden death of a full production cycle. Nitrogen Sensing Solutions proposes a game-changing solution, using an innovative biosensing technology that is mastered by this science-driven startup. The minimum viable product is a portable nitrite biosensor - the NO2Aqua – that can be easily used onsite a deliver accurate results in real-time. Our second product (NOxAqua) can monitor the three N-nutrients at the same time, whereas our third product (NOxAquaPlus) will offer automation in a customized analyzer equipped with a complete sensors package, a data transmission system, and protocols for emergency response, thus reducing risks of heavy mortality and taking the RAS-based industry to Aquaculture 4.0. The company was founded by its CEO, a female researcher who moved recently to the entrepreneurship space and is willing to take the deep technology developed in her research group to the marketplace. However, the team lacks experience in business development and management and is looking for mentorship and coaching. In addition, we are seeking support to perform customer (re)discovery, and to update the business plan, market deployment strategy, and IP strategy. Lastly, we aim to promote awareness of the NOxAqua brand. As so, we are a good fit for the Women TechEU program.

Keywords: nitrogen water quality biosensors aquaculture blue growth sustainable food recirculating aquculture systems
Soft-exoskeleton suit To Restore Autonomous Locomotion (STROLL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2449676.25
EU funding (EUR): 2449676.0
Participants: 1
Project status: SIGNED

Imagine putting on a pair of pants, it feels soft like ordinary clothing fabrics, but unlike any other, this one is made of high-performance robotic soft actuators and soft sensors. This is my vision of future exoskeletons being just like everyday clothing, light, soft, and powerful enough to fully support the wearer. The loss of the ability to walk is devastating for many suffering from stroke, spinal cord injury, and alike. An ergonomic, light-weight exoskeleton can surely help these patients to walk again autonomously. This is challenging due to large gaps between conventional rigid body dynamic-based walking control and soft structures because such an exoskeleton has to integrate high-performance soft mechatronics, to perform walking to an unprecedented extent. I am uniquely qualified to achieve this due to my extensive experience in the fields of robotics and neuroengineering, as well as my leading role in the engineering of world-leading high-performance humanoid robots which incorporate control, modelling, and experimental evaluation. STROLL will develop a soft wearable robotic exoskeleton to restore the walking capability of patients with lower-body paralysis. The soft wearable exoskeleton that I propose to develop will combine ground-breaking innovations in advanced high-performance textile-based actuators, lower-body tactile sensors, and advanced locomotion control. STROLL will investigate new control strategies and methods for tactile-based control for balancing and walking. As its ultimate goal, STROLL will take on the ambition to enable a lower-limb paralysed person to take a stroll in the park with an autonomous soft textile exoskeleton. Despite the methodological difficulties and the uncertainty of the results, the project is more than worth pursuing, as the pay-off is highly significant to benefit the lives of millions of patients suffering from lower-limbs disorders.

Keywords: soft exoskeleton
SUSTainability-Advanced and Innovative Networking with 6G (SUSTAIN-6G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Germany,France,Sweden,Belgium,Italy,Finland,Greece,Spain,United Kingdom,Austria
Call: Sustainability Lighthouse (HORIZON-JU-SNS-2024, 2024)
Start date: 2025-01-01
End date: 2027-06-30
Duration (months): 30.0
Total project cost (EUR): 13981228.75
EU funding (EUR): 12999999.99
Participants: 24
Project status: SIGNED

SUSTAIN-6G will develop a holistic sustainability framework in the context of 6G, addressing all three sustainability areas (environmental, societal, economic), and factors impacting sustainable 6G technology and 6G technology for improving verticals’ sustainability. The framework will be applied to key vertical sectors, in an end-to-end manner, considering the full lifecycle of assets. SUSTAIN-6G will identify the cross-points between what sustainability needs are, which challenges 6G and verticals need to consider, what 6G should do to address these challenges, and how society and economy benefit from responsible innovation. To achieve this, the project will provide a driving force for multiple activities and a hub, to integrate research and innovation from previous and ongoing projects, develop innovative concepts and solutions, and address gaps and trade-offs in technology, processes and methodologies. The concepts and solutions will be validated and evaluated by proof-of-concepts on their sustainability impact and performance. The insights from these PoCs, and the proven processes and methodologies will be consolidated into guidelines, best practices and roadmaps to drive the full integration of sustainability aspects into future communication and vertical systems, in close collaboration with stakeholders and other SNS projects, and for use across the EU and beyond. The outputs and impact of SUSTAIN-6G will provide the foundation for industry-wide standardisation that will enhance existing ecosystems, help to shape a sustainable future that develops and thrives within planetary boundaries, and strives to protect and restore the environment, while respecting EU values and rules. Recognising the complexity and multifaceted characteristics of sustainability, SUSTAIN-6G will achieve these objectives through its multidisciplinary consortium, composed of 6G and vertical technology, social science, and economic experts, and with relevant external stakeholders.

Keywords: sustainability,sustainable 6g,6g for sustainability
Therapies for Renal Ciliopathies (TheRaCil)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Germany,Netherlands,Italy,United Kingdom,Denmark
Call: Development of new effective therapies for rare diseases (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-07-01
End date: 2027-06-30
Duration (months): 48.0
Total project cost (EUR): 7425446.8
EU funding (EUR): 7425446.8
Participants: 17
Project status: SIGNED

Ciliopathies are a large group of rare and severe genetic diseases caused by dysfunction of the primary cilium, a microtubule-based cell surface antenna that controls key signaling output required during development and tissue homeostasis. Cilium dysfunction leads to complex disorders with high genetic heterogeneity and overlapping phenotypes. Despite the broad clinical spectrum, chronic kidney disease (CKD) leading to end stage kidney disease (ESKD) is a common cause of morbidity across ciliopathies. Currently, the only available standard of care for CKD is based on dialysis and transplantation. Renal ciliopathies represent a main cause of ESKD during childhood and despite the identification of more than 40 causative genes, it remains difficult to predict the severity of the disease as well as the risk of appearance (if not present at diagnosis) and the rate of progression of renal failure. TheRaCil therefore aims: (1) to improve diagnosis and prognosis of at risk pediatric renal ciliopathy patients, and (2) to implement therapeutic approaches aimed at targeting shared pathological pathways, at modifying mRNA targets of the causative or modifier genes by antisense oligonucleotides and by the repurposing of available molecules. These goals will be achieved through the federation of our unique databases of pediatric renal ciliopathies cases available across Europe, which will allow a better stratification of patients, the identification of modifier genes and markers of disease progression. Bioinformatics approaches will be used to integrate patients’ biological and genetic data as well as multi-omics and functional analyses from patients samples and preclinical models. These analyses should lead to the identification of shared targetable pathological pathways as well as of patients eligible for the identified new therapeutic approaches which will be evaluated in robust preclinical models.

Keywords: ciliopathies,chronic kidney disease,antisense oligonucleotides,modifiers,personalised medicine,ai technology,preclinical models,patient centered outcomes,nph,arpkd,clinical trial readiness