Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Self-Assembly: Shifting our View of Life (AssemblingLife)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1974940.0
EU funding (EUR): 1974940.0
Participants: 1
Project status: SIGNED

Biology invites us to understand life as “hard work”. Living beings are mainly viewed as systems requiring the constant input of energy and the detailed regulation by genetic material. These ideas of life very much influence the general understanding of living systems, and, particularly interesting for this project, it influences current philosophy of science accounts of the understanding and explanation of living processes. But what if life is much less “hard work” than often presented? And what if genes should be understood as “nudgers” rather than as “directing” living processes? Self-assembly is the spontaneous formation of complex patterns and structure. It can be visualized as a pile of lego bricks turning into a Ninjago fortress on its own. There are no lego-builders. The parts “self-assemble”, possibly as a result of chemical and physical processes working between and on the parts. Recent nanoscience research efforts at the intersection of chemistry, biology, and material science, increasingly utilize self-assembly processes in the development of new materials, technologies and understanding of living systems. AssemblingLife will, on an interdisciplinary basis, build a new theoretical framework withing the philosophy of science for understanding and explaining life, building on the increasing focus and knowledge about self-assembly processes that carry the potential to shift our view of life. The project will provide a new understanding of genetic causation starting from the idea of genes as “nudging” self-assembly processes rather than as providing detailed regulation, and it will develop new theory of scientific explanation that will account for the observation that self-assembly processes do not behave like classical mechanisms or interventions targets. AssemblingLife plan for contributing novel and needed theory and conceptual tools both to the philosophy of science and to the empirical life sciences.

Keywords: philosophy of biology,philosophy of life science,philosophy of nanoscience
DSO for Digital Twins (DSO4DT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Cluster 5 other
Destination: Other Climate, Energy and Mobility destinations
Action type: Coordination and support actions
Countries involved: Belgium
Call: ENTSO-E and the EU.DSO Entity cooperation in the realisation of a Digital Twin of the EU Electricity Grid (HORIZON-CL5-2024-EUDSO-IBA-2, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 750000.0
EU funding (EUR): 750000.0
Participants: 1
Project status: SIGNED

DSOs for Digital Twins accelerating the uptake of Digital Twins of the European electricity grid across Europe.

Keywords: digital twins,dso,eu electricity grid,digitalisation
Advanced Technologies for High value imagiNg Applications (ATHENA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: France,Spain,Italy,Austria,Romania,Sweden,Greece,Germany,Türkiye,Ireland
Call: Global call according to SRIA 2023 (RIA) (HORIZON-KDT-JU-2023-2-RIA, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 38917104.63
EU funding (EUR): 12008241.73
Participants: 24
Project status: SIGNED

New strategic and growing markets related to connectivity, mobility, automotive, health and earth monitoring call for improved imaging solutions in visible, LWIR and VLWIR offering advanced functionalities and cost effectiveness. Visible imagers market is currently largely dominated by non-European countries. LWIR µbolometers imagers, fabricated above-IC, have not yet been democratized for high volume markets due to the difficulty to solve performance versus cost equation. However, Asian providers are making important progress to tackle this challenge. ATHENA aims at strengthening European economy in high-tech imaging technologies: - by taking advantage of 3D stacking technologies, improved sensor-processing integration, multimodal 2D/3D functionalities - by preparing the manufacturing of µbolometers from 200mm to 300mm CMOS wafers for productivity gain and access to more advanced CMOS nodes for improved functionalities, developing cost effective LWIR wafer level optic solutions - by using new methods of growing and doping materials for future VLWIR imager manufacturability. This will foster new applications related to automated systems (in industry, border and security management), health and consumer markets, and earth & climate monitoring. ATHENA gathers a strong European consortium composed of highly renowned Research Technological Organizations, big industrial players in imaging technologies and end-users to specify, design, develop, test these technologies in use cases and set common specifications for the imagers to support their industrialization and widespread adoption. In line with both the European Union’s Chips Act and the Electronics, Components and Systems Strategic Research and Innovation Agenda, ATHENA will not only address the development of new sensors and chips, but also their integration in larger systems to pave the way to promising applications. ATHENA will strongly contribute to Europe leadership, industrial competitiveness and sovereignty.

Keywords: visible,lwir,vlwir,microbolometer
Uniting Statistical Testing and Machine Learning for Safe Predictions (SafetyBounds)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Recent breakthroughs in machine learning (ML) have brought about a transformative impact on decision-making, autonomous systems, medical diagnosis, and creation of new scientific knowledge. However, this progress has a major drawback: modern predictive systems are extremely complex and hard to interpret, a problem known as the ’black-box effect’. The opaque nature of modern ML models, trained on increasingly diverse, incomplete, and noisy data, and later deployed in varying environments, hinders our ability to comprehend what drives inaccurate predictions, biased outcomes, and test time failures. Perhaps the most pressing question of our times is this: can we trust the predictions for future unseen instances obtained by black-box systems? The lack of practical guarantees on the limits of predictive performance poses a significant obstacle to deploying ML in applications that affect people's lives, opportunities, and science. My overarching goal is to put precise, interpretable, and robust error bounds on ML predictions, communicating rigorously what can be honestly inferred from data. I call for the development of protective ecosystems that can be seamlessly plugged into any ML model to monitor and guarantee its safety. This proposal introduces a unique interplay between statistics--the grammar of science--and ML--the art of learning from experience. Leveraging my expertise in both domains, I will show how statistical methodologies such as conformal prediction and test-martingales can empower ML, and how recent breakthroughs in ML such as semi-supervised learning and domain adaptation technologies can empower statistics. I will tackle challenges rooted in real-world problems concerning (1) availability and (2) quality of training data, as well as (3) test-time drifting data. A successful outcome would not only lead to a timely and rigorous way toward safe ML, but may also significantly reform the way we develop, deploy, and interact with learning systems.

Keywords: machine learning,statistical testing,uncertainty quantification,conformal prediction,safe machine learning,reliable machine learning
Structure and functions of terrestrial phycospheres (PHYCOSPHERES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1499544.75
EU funding (EUR): 1499544.75
Participants: 1
Project status: SIGNED

Microscopic algae release organic compounds to the region immediately surrounding their cells, known as the phycosphere, constituting a niche for colonization by heterotrophic bacteria. These bacteria consume algal photoassimilates and provide beneficial functions to their host, in a process that resembles the establishment of microbial communities associated with the roots and rhizospheres of land plants. Phycosphere communities have been well studied in aquatic environments, where they are known to play important roles in nutrient and energy fluxes. For many species of algae, interactions with their associated phycosphere bacteria can also provide beneficial functions, often mediated by metabolic exchanges. Despite the known importance of these associations in aquatic environments, their role in terrestrial ecosystems and parallels with the root microbiota of land plants have not yet been resolved. The goal of this project is to employ a newly developed reductionist host-microbiota system based on the model chlorophyte alga Chlamydomonas reinhardtii to study the structure and functions of terrestrial phycospheres and identify the core ecological principles that explain the overlap between the root and phycosphere microbiota. Using a variety of gnotobiotic systems and synthetic communities composed of phycosphere bacteria, we will study the genetic and molecular mechanisms that drive host-microbiota interactions in C. reinhardtii and as well as their evolutionary origins and conservation in other lineages of green algae and land plants. Finally, we will design and build synthetic phototrophic microcosms based on terrestrial phycospheres using bioreactors to explore the ecological and molecular mechanisms underpinning microbiota diversity, stability and functions. This project has the potential to reveal fundamental, quantitative principles governing the dynamic behaviour of host-associated microbial communities.

Keywords: microbial ecology,microbiota,algae,phycosphere,chlamydomonas,plant microbiota
Coherent Control of Chiral Molecules (COCOCIMO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1809735.0
EU funding (EUR): 1809735.0
Participants: 1
Project status: SIGNED

The ambitious goal of this project is to create an enantiomer-pure beam of chiral molecules, starting from a racemic sample, using an experimental coherent state preparation scheme. The basic elements of the proposed experiments are the following. A cold, gas-phase beam of chiral molecules is created via supersonic jet expansion. Two levels of a triad of rotational states that are connected via electric dipole allowed transitions are emptied using resonant UV depletion in combination with simultaneous microwave repumping. Driving a closed triad of rotational transitions using microwaves prepares a chosen internal quantum state of the chiral molecules enantiomer-specifically. This is called enantiomer-specific state transfer; a new method, that I co-developed. After coherence preparation using collimation, state-selective matter-wave diffraction is accomplished using a resonant, absorptive optical grating. The diffracted enantiomer-pure beam is detected state-selectively using 2D planar laser-induced fluorescence detection. Eventually, this beam can be used for further spectroscopic or scattering studies or for depositing the enantiopure sample on a surface. The scheme that is to be demonstrated in COCOCIMO will be applicable to any chiral molecule.

Keywords: chirality matter wave interferometry enantiomer separation cold molecules
Biomass-derived Sustainable Fuels by cascade Condensation and hydrodeoxygenation on single atom catalysts (Bio2SAF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

Lignocellulose is the largest renewable carbon source that does not compete with food, or land and can be catalytically converted into fuels. Accessing such high-value chemicals and biofuels is challenging due to the high strength of C-O and C-H bonds, requiring high-energy or multi-reaction steps. Thus, the strategic frontier of the Bio2SAF project aims to design a novel multifunctional single-atom catalyst utilizing densely and selectively functionalized graphene for sustainable fuels by cascade condensation and hydrodeoxygenation on non-noble metal heterogeneous catalysts. Single-atom catalysts (SACs) may effectively perform HDO due to the selective adsorption of reactants on highly exposed active sites due to the lower density of state (DOS) near the Fermi level than the bulk catalysts. Bio2SAF develops in three pillars: development of tandem Oxophilic single atom super doped graphene: SD-G-SACs-I (M1: Ti, Mo, W, Nb, Zr for acidic functions & Mg, Ca for basic catalysis) for condensation. This design aims at the efficient production of longer condensed species from the bio-derived components to cyclic and non-cyclic alkanes in the range of C9-C16 at high selectivity. The second pillar aims at the development of tandem non-noble metal single atom super doped graphene: SD-G-SACs-MII (M2: Ni, Cu, Co, Fe etc.) for hydrodeoxygenation of aldol condensation products. The third pillar focuses on development of graphene derivatives structurally and chemically tailored with dense MI and MII-type SACs for cascade reactions. By levering the know-how and documented expertise of the host institution on graphene chemistry and single metal atom engineering and of the experienced researcher on biomass valorization and catalysis, Bio2SAF will apply and expand these concepts towards sustainable production of fuels from waste biomass. The Bio2SAF project will thus tackle pressing societal needs to develop technologies for decreasing our dependence on depleting fossil fuel reserves

Keywords: biomass,sustainable fuels,single atom catalysts,densely functionalised graphene,cacade condensation and hydrogenation,catalytic transfer hydrogenation
Selective Alkylation of Complex Molecules in Flow (SELECTFLOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Developing new pharmaceutically-active molecules for the treatment of diseases that compromise the health and well-being of society is an essential but tedious process with rising costs, partially due to the arduous chemical synthesis of complex drug candidates. Recently, innovations in organic chemistry have streamlined the access to vast libraries of drugs by applying novel methodologies such as Late-Stage Functionalization of C-H bonds. However, one of the major challenges of editing biologically-active chemical structures is the development of processes that are compatible with diverse functional groups and functionalize one single position "à la carte" in an efficient and predictable manner. SELECTFLOW presents a multidisciplinary project that lies in the intersection of synthetic photoredox catalysis with microfluidic technologies, with the objective of delivering a selective, sustainable and predictable methodology for the modification of biologically-active molecules using light alkanes as raw materials. This will require the accomplishment of three specific objectives: 1) Development of a chemo- and regioselective synthetic methodology for the edition of nitrogen-containing aromatic heterocycles. 2) Translation of the developed photocatalytic system into a microflow-based setup, to enable the use of gaseous reagents in a milder and scalable fashion. 3) Understanding the mechanistic intricacies of the developed methodology in order to predict unexplored similar transformations. Overall, this proposal directly tackles one of the most important challenges for the pharmaceutical industry, the rapid and cost-effective production of innovative drugs, by delivering a sustainable valorisation of greenhouse gases, such as methane. It is expected that this innovative approach will be of high scientific, technological and societal impact, ultimately reinforcing the already European competitiveness in the production of life-saving drugs.

Keywords: flow chemistry,late stage functionalization,c h activation,catalysis
New chemical warheads for covalent drug discovery (Cyclo-warhead)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Over the past two decades, the pharmaceutical industry has witnessed an exponential growth in approved covalent drugs. The majority of such drugs incorporate a chemical warhead, a mild electrophilic reactive functional group that forms covalent bonds in a reversible or irreversible manner with nucleophilic aminoacid residues. The aim of this proposal is to assess the viability of a new chemical warhead in the discovery of novel kinase inhibitors.
Extended degrees of freedom in QFT (EXTENDED)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499728.0
EU funding (EUR): 1499728.0
Participants: 1
Project status: SIGNED

Quantum field theory (QFT) is the formalism that underlies modern particle and condensed matter physics. Standard perturbative methods in QFT have been extraordinarily successful in explaining physical phenomena involving weakly-interacting quantum fields. On the other hand many fundamental phenomena, including phase transitions and nuclear interactions, are described by strongly coupled QFTs for which perturbative techniques are insufficient and a rigorous, predictive theoretical formulation is lacking. Heuristic arguments indicate that a full non-perturbative formulation of QFT must include extended degrees of freedom (a prototypical example being the flux tubes that bind quarks inside the nucleus). My proposal describes a novel approach for studying extended objects in a wide range of QFTs, based on two recent conceptual breakthroughs: first, my research on a special class of theories (the six-dimensional SCFTs) has brought to light a rich algebraic structure that captures the properties of its stringlike excitations; and second, new developments in mathematics and physics point to the existence of a vast generalization of this structure, which is perfectly suited to describe the extended objects of a much wider range of QFTs. This program is organized along three directions: analyze the families of QFTs that can be studied by string-theoretic and geometric methods, and gradually uncover the algebraic structures that describe their extended degrees of freedom; exploit these algebraic structures to obtain novel principles that govern the dynamics of strongly-interacting QFTs; and determine the new mathematical structures that arise from the combination of the geometric and algebraic description of the extended objects. An ERC starting grant will allow me to undertake this ambitious project whose pursuit will lead to a much deeper understanding of extended degrees of freedom, or their role in QFT, and of the mathematical structures that describe them.

Keywords: non perturbative methods in quantum field theory supersymmetric qfts superconformal field theory geometric engineering topological string theory