Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Vulnerability of esophageal cancer to their addiction to kinase activities: evaluation and prediction of eSCC tumors responsiveness to kinase inhibitors. (Kinaddict)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-16
End date: 2021-09-15
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

In decades, the 5-year survival rate of several cancers has barely been improved and the esophageal squamous cell carcinoma (eSCC) is not different with a rate around 25%. In order to increase the survival, chemoradiotherapy prior surgery has become the reference for eSCC despite still a high mortality. eSCC tumors harbor a variety of genetic alterations directly or indirectly affecting the activity of kinases involved in signaling pathways, the cell cycle or the proliferation. Evidence on how eSCC tumors are addicted to such oncogenic alterations remains missing to evaluate alternative treatment modalities. The heterogeneity of eSCC tumors presenting deregulations of diverse constellations of kinases has rendered difficult the development of a unique therapeutic strategy similar to prior successes targeting EGFR or BCR-ABL. However, as the CDK4 activity lies downstream from most of the oncogenic deregulations of signalling pathways, it has been proposed to represent the therapeutic target of choice, confirmed by the first approval by the FDA/EMA of 3 CDK4/6 inhibitors to treat ER+ breast cancer. Despite this, not all tumors respond to CDK4 inhibition and long-term treatment triggers escape mechanisms. In this context, the main aim of the present proposal consists to preclinically evaluate if and how eSCC respond to inhibitors targeting kinases with an altered activity using a multi-omics approach. In this cancer, we will (1) identify the kinases with a deregulated activity associated to different genetic landscapes and determine the addiction of eSCC to their activity, (2) characterize the sensitivity of eSCC tumors to CDK4 inhibition and decipher their molecular response for effective combined targeted therapy, and (3) experimentally define the treatment modalities of eSCC in mouse models. The results will provide a strong basis to extend the study with clinicians to human tumors to determine biomarkers of responsiveness to efficient alternative therapy.

Keywords: kinase activity,cdk4,oncogene addiction,mass spectrometry,chemotherapy
Functional high-throughput analysis of the role of microRNAs in regulating Staphylococcus aureus infection (miRs4Staph)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-15
End date: 2022-10-14
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Staphylococcus aureus is an opportunistic bacterial pathogen that causes acute and chronic infections responsible for a broad spectrum of human diseases. The high prevalence of antibiotic-resistant strains in clinical context and the spreading of these strains in the community, make S. aureus infections a leading cause of morbidity and mortality in developed countries. A better understanding of the factors contributing to bacteria resistance and host-pathogen interaction is essential to counteract S. aureus infection and, ultimately, to develop more effective therapeutic approaches. MicroRNAs (miRNAs) are genome-encoded small non-coding RNAs, which play a pervasive role in the post-transcriptional control of eukaryotic gene expression. Emerging evidence supports a determinant role for miRNAs in the interplay between bacterial pathogens and host cells, as part of the immune response, or as a molecular strategy exploited by pathogens to subvert host cellular functions. However, a comprehensive analysis of host miRNAs function during infection by S. aureus is still missing. The main goal of this project is to identify and characterize host miRNAs, which are critical for S. aureus-host interaction at the cellular level. This will be achieved through interdisciplinary and innovative strategies, such as large-scale genome-wide miRNAs screenings and high-content analysis. To increase the biological relevance of the study, the effect of selected miRNAs will be validated in S. aureus clinical isolates obtained from osteomyelitis patients. The identification and characterization of miRNA molecular targets will be based on computational and experimental approaches. Through the application of cutting-edge techniques, this project will reveal previously unappreciated factors/pathways essential for S. aureus infection, providing insights into the complex host-pathogen interplay. Additionally, the identified novel factors/pathways may be explored for therapeutic intervention.

Keywords: staphylococcus aureus,high throughput,high content screening,micrornas,host bacterial pathogen interactions
Transient Engine Driven Explosions (TEDE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands,United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 1987299.25
EU funding (EUR): 1061384.59
Participants: 3
Project status: SIGNED

The nature of many of the most energetic explosions in the Universe remains a central unanswered question in contemporary astrophysics. While progress has been made towards the origins of many of the more commonly observed transients – including “normal” core collapse supernovae and long-duration gamma-ray bursts – there remain important mysteries, both new and old. Recent studies suggest that many of the most energetic explosive transients are powered by a central engine that is either an accreting black hole or a highly magnetic neutron star (a magnetar). These engines input energy into the explosion and transform the later emission, as well as having a profound impact on metal yields, feedback into the interstellar medium, remnant evolution, particle acceleration (e.g. high energy cosmic rays) and neutrino production. The creation of the engine may also produce strong gravitational wave transients, which are likely to be discovered (if they have not already been) by the new generation of ground-based interferometers. I propose a detailed study of engine driven transients throughout the Universe, utilizing insights from both the transients themselves and their local and wider environments. In particular, my work will; a) search for evidence of long-lived engines in the longest gamma-ray bursts, and determine the effects these engines have on the appearance of associated supernovae, b) determine the properties of engines in very long gamma-ray transients thought to be tidal disruption flares, and determine if these are indeed tidal flares or unusual supernovae c) map the properties of the engines seen in short-GRBs, allowing us to hone our expectations for d) the identification and study of the first electromagnetic counterparts to GW sources, and their environments. I will achieve this by the creation of an experienced team of postdoctoral fellows and senior staff with a skills-set tuned to address these central questions.

Keywords: gamma ray bursts,tidal disruption events,supernovae
Enhancing brain function and cognition via artificial entrainment of neural oscillations (ENTRAINER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1497104.0
EU funding (EUR): 1497104.0
Participants: 1
Project status: SIGNED

Neural oscillations are ubiquitous in the human brain and have been implicated in diverse cognitive functions to support both neural communication and plasticity. Their functional relevance is further supported by a large number of studies linking various cognitive deficits (e.g., attention deficit hyperactivity disorder, ADHD) with abnormal neural oscillations. However, this field of research faces two important problems: First, there is only correlative, but no causal evidence linking cognitive deficits to abnormal neural oscillations in humans. Second, there is virtually no theory-driven mechanistic approach that generates insights into how oscillations within and across neural networks are linked to human behavior. In this project, I propose to take decisive steps to provide a long-needed neurophysiological characterization—via (1) computational modelling, (2) electrophysiological measures, and (3) novel non-invasive manipulations of cortical rhythms—on how neural oscillations contribute to two types of cognitive processes that are fundamental for many aspects of human behavior: attention and short-term memory. I will go a step further by demonstrating that it is possible to augment performance in these cognitive functions with the design of non-invasive brain stimulation protocols individually tailored to the theory-driven neurocomputational characterizations and electrophysiological signatures of each individual. This will result in the applied goal of deriving new neuro-computational assays that can detect deviant network interactions causally related to cognitive functions, which is key for then renormalizing those functions in neuropsychological conditions such as ADHD. Thus, if successful, my proposed work will ultimately result in novel, low-cost, and painless non-invasive neural interventions for a wide range of neuropsychological disorders tied to abnormal neural oscillations.

Keywords: brain stimulation,fmri,oscillations
Made in Sweatshops. Worker, technology and Gender (comparison Paris-Shanghai, Late 19th c.-Late 20th c.) (MISS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: SIGNED

Made in SweatShops. Worker, Technology and Gender (Comparison Paris-Shanghai, Late 19th c.-Late 20th c.) Made in Sweatshops (MISS) proposes to study the female workers in the clothing industry through an analysis of workshop techniques and a comparison between two major manufacturing centres: Paris from 1860 to 1900 and Shanghai from 1990 to 2020. By re-evaluating the relationships between bosses, middlemen and female workers, and the links between techniques, qualification, de-skilling and gender , MISS will offer a new way of thinking about female work and the gender of technologies.The objective is to examine how the technical tools of the workshops have affected the lives of women workers in the long term and have contributed to the systematic organisation of the misery of women's work. The comparison between Paris and Shanghai is justified because these two economic centres of the clothing industry are both design and manufacturing centres. At present, the garment industry in the neighbouring province of Shanghai, Zhejiang, is openly modelling its development on that of Paris in the 19th century . New York and London have never been design and manufacturing centres at the same time. This double simultaneity only characterizes Paris and Shanghai. My core hypothesis in MISS is that technology management is a determinant point of this industry. Technological "progress" in the clothing industry has very negative effects on the know-how, the misery migrations, the working conditions of the workforce, women's employment and career prospects. It contributes to the impoverishment of creative industries in a context of globalisation . Paris and Shanghai are excellent sites for observing the implementation and reproducibility of an industrial model aimed at de-skilling the workforce through technology in order to respond to the constant growth in volumes of clothing at lower cost.

Keywords: clothing industry,fashion,textile
Daily Experiences of Successful Ageing (DEXSAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

Older adults’ daily experiences were shown to be detrimental to their Successful Ageing. Empirical studies demonstrate that the type and quality of daily activities are constitutive for senior citizens' Quality of Life, and for how many more years they would like to live. Meanwhile, there are very few studies collecting data on daily activities from respondents aged 65+. Even fewer collect information on respondent’s evaluation of these activities. This project aims to give voice to the respondents by collecting data on everyday events and their subjective perception by individuals aged 65+. It will use a time-use approach, i.e, Experience Sampling Method (ESM) including important methodological innovations. Three algorithms will be used to collect different but compatible sets of time-based data and allow for comparative analyses between them. Data collection will take one week per person and each individual will provide information on 15-50 time-points. First algorithm will use classic ESM approach to provide information on how events are plotted across the day and the week, and how wellbeing fluctuates depending on time and day. Second algorithm will allow respondents recording events which are meaningful to them and most detrimental to their wellbeing. Third algorithm will provide information on events considered essential for how a day is structured. Altogether the three datasets will be used to answer questions about the dynamics of elderly’s days, how they experience different activities and how these experiences affect their wellbeing and quality of life. We aim at promoting this project as bringing essential new knowledge not only for policy-makers but also for practitioners and elderly individuals themselves. Along with scientific publications, easy-to-understand brochures including main findings and recommendations will be made available online.

Keywords: successful ageing,quality of life,time use,behaviours,subjective wellbeing,older adults
Malopolska Researchers' Night 2014-2015 (Power2Nights)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland,Poland,Poland,Poland
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 443723.5
EU funding (EUR): 354506.0
Participants: 13
Project status: CLOSED

The project Malopolska Researchers' Night will be implemented in the years 2014 and 2015 respectively for the eighth and ninth time. The event has already permanently inscribed in the calendar of Malopolska scientific events, enjoying growing from year to year popular among participants and becoming one of the biggest Nights in Europe. In 2013, this event was attended by over 55 thousand people, while in the first year of the project (2007) the event was attended only by 3.5 thousand people. The event program specified in the application is even richer than before – it will take over 1 thousand activities, mainly interactive workshops, presentations, demonstrations and experiments as well as shows with the participation of scientists. It is estimated that 60 thousand people will participate in the events in 2014 and 65 thousand people in 2015. Malopolska Researchers' Night is to first of all show participants how interesting is the work of scientists and how fascinating they are people. Through fun, in accessible and understandable way for everybody, we want to show that all around us is the science, and that scientists in their laboratories are working every day to make our life better, easier and more modern. The main motto of the project for the years 2014 and 2015 will be to present the successes of Malopolska scientists working in international scientific-research teams. The event will be held in six cities of the Region: Krakow, Tarnow, Nowy Sacz and Niepolomice and - for the first time in 2014 - also in Skawina and Andrychow. In addition, it is planned the live broadcast from selected locations via event website. The program will be prepared by almost 900 researchers, more than 1 600 students, about 120 research groups from more than 30 partners. Thanks to the extensive promotional campaign the information about the event will reach to nearly 3.5 million people each year.

Keywords: communication,science,promotion,public recognition,research,integrity,consistency,technology,laboratory,performance,demonstration,experiments,workshops,shows,exhibitions,competitions
Unleashing the potential of Crowdfunding for Financing Renewable Energy Projects (CrowdFundRES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Austria,Germany,Ireland,Germany,Belgium,France,France,Netherlands,United Kingdom,Jersey,United Kingdom
Call: Market uptake of existing and emerging renewable electricity, heating and cooling technologies (H2020-LCE-2014-3, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 1994915.0
EU funding (EUR): 1893002.5
Participants: 16
Project status: CLOSED

We are currently seeing a deceleration of renewable energy growth in Europe. This is partly attributed to the challenges for financing renewable energy projects. Reduced access to conventional financing options over the past few years has triggered innovative financing schemes to emerge, with crowdfunding attracting a lot of attention. CrowdFundRES recognises the vast potential of crowdfunding for financing renewable energy projects. The project has been developed for and in cooperation with the three target groups: 1) Renewable energy project developers whose access to financing is getting more challenging 2) The part of the public that has an interest in investing even very small amounts of their savings in renewable energy projects 3) Crowdfunding platforms who act as intermediaries facilitating the financial transaction between the public and the project developers. The overall objective of the proposed project is to contribute to the acceleration of the renewable energy growth in Europe by unleashing the potential of crowdfunding for financing renewable energy projects. In order to achieve this, the work has been structured for achieving the following objectives: 1. Gain a deep understanding of the public’s perception of crowdfunding 2. Analyse the challenges faced by the application of crowdfunding for renewable energy projects in Europe 3. Develop guidelines that support easier, more effective and wider accepted practices in crowdfunding renewable energy projects 4. Apply the guidelines and review them based on practical experience 5. Improve the market and regulatory framework 6. Promote the crowdfunding concept and its advantages among those who could contribute or raise funds

Keywords: renewable energy,crowdfunding,innovative financing,fund raising,project development,citizens,public,communities,public acceptance,platform
FRAGMENT screening from advanced-sampling molecular dynamics simulations on a proteOME scale. (FRAGMENTOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-06-04
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

In Fragment-Based Lead Discovery (FBLD) highly sensitive biochemical and biophysical screening technologies are used to detect the low-affinity binding of low-molecular-weight compounds (the so-called fragments) to biological targets that are involved in pathophysiological processes. Knowledge of the molecular interactions between fragment hit(s) and the target protein allows the rational generation of high-quality leads for drug development. Thus, high-resolution (e.g. X-ray crystallography) and relatively high-throughput structure determination technologies are key to this approach but they can become a limiting factor for both technical and economical reasons. As a matter of fact, when the experimental characterization of binding mode fails, the success rate of FBLD approaches drastically drops. To overcome current limitations in FLBD, here we propose the development of a computational framework based on advanced-sampling molecular dynamics simulations to map the binding of fragments to protein surfaces on the proteome scale---thus generating the Fragmentome Altas. For each individual target this will allow to: a) systematically identify fragments binding to protein surfaces and cryptic pockets; b) reconstruct the mechanism of binding with atomistic spatiotemporal resolution; c) characterize the molecular determinants of affinity and kinetics in fragment-protein complexes. This insight is fundamental for optimizing and evolving fragments to lead compounds with desired thermodynamics and kinetics features. To date, neither experimental nor computational approaches can provide such information at affordable costs while maintaining the high throughput needed for screening campaigns. The successful implementation of this ambitious project lies in the unique combination of expertise of its participants, and it will allow a novel state-of-the-art for modern drug discovery to be established. The Fragentome Atlas will be a freely accessible on-line server.

Keywords: fragment based lead discovery,enhanced sampling molecular dynamics,free energy,calculations,computer aided drug design,protein ligand interactions,biophysics