Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanisms of memory formation in cortical networks during learning of goal-directed behaviors (LearningNetworks)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2110000.0
EU funding (EUR): 2110000.0
Participants: 1
Project status: SIGNED

A central hypothesis in neuroscience is that changes in connectivity patterns between neurons support learning and memory formation. Most methods for examining connectivity between individual neurons rely on ex vivo experiments (e.g., in brain slices). However, in vivo measurements are required to study how neurons causally influence each other's activity ('causal connectivity') in the living brain, and how these causal interactions change over time. Thus, while brain networks are among the most studied biological networks, the cellular-level patterns and dynamics of causal connectivity in vivo remain unknown. Here, I propose to study how causal connectivity between individual neurons and across entire brain areas changes over time during learning of memory-guided behaviors. To this end, we will use novel causal optical methods to longitudinally map causal connectivity and neural activity at cell resolution in vivo, focusing on the motor cortex and related areas. We will combine these methods with a novel goal-directed behavior in mice that does not require pretraining, which will serve as a baseline to study learning mechanisms of more complex behaviors that rely on short-term memory. Specifically, we will map changes in causal connectivity during learning within the motor cortex (Aim 1) and across cortical areas (Aim 2) and relate it to the computational functions of the network. We will also perturb neurons based on their connectivity and coding properties to identify changes in network mechanisms for short-term memory and action selection at various learning stages (Aim 3). Finally, we will work towards identifying constraints on memory formation via optogenetic induction of artificial connectivity patterns. Taken together, this research will enable for the first time to causally study dynamics in network interactions across time on different spatial scales, and to test fundamental mechanisms of memory formation and representation in cortical networks.

Keywords: network connectivity,short term memory,optogenetic perturbations,memory formation,learning,effective connectivity,causal connectivity,motor cortex,attractor dynamics,action selection,decision making
Next Generation Solutions for Sustainable, Inclusive, Resource-efficient and Resilient Cultural Heritage (INHERIT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Research and Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Greece,Latvia,Poland,Spain,Sweden,Türkiye,United Kingdom,Austria,Germany,Netherlands,Italy,Croatia,France
Call: Sustainable and resource-efficient solutions for an open, accessible, inclusive, resilient and low-emission cultural heritage: prevention, monitoring, management, maintenance, and renovation (Built4People) (HORIZON-CL5-2022-D4-02, 2022)
Start date: 2023-10-01
End date: 2027-03-31
Duration (months): 42.0
Total project cost (EUR): 4999900.0
EU funding (EUR): 4999900.0
Participants: 21
Project status: SIGNED

Culture heritage - tangible and intangible - can be understood as a reservoir of creativity, well-being, identity and knowledge that is useful to overcome present and future challenges. The cultural value attributed to our traditional and historic buildings denotes our identity as communities and individuals, playing an important role both in urban and rural domains. The historic building stock is heterogeneous and consists of buildings from different time periods, constructed in different ways with different materials, and also follows different architectural ideals. This situation implies that there is a need for differentiated renovation strategies and targeted policies along the heritage built environment’s life cycle that promote energy efficiency, sustainability, inclusiveness and resource efficiency, while preserving cultural heritage value. The overall vision of INHERIT is to create a systematic methodology, accompanied by leading-edge Information and Communication Technologies (ICTs), such as Internet of Things (IoT), Artificial Intelligence (AI) and (big) data analytics, and associated social/behavioural practices, towards sustainable, inclusive and resource-efficient CH solutions. INHERIT will enable socially innovative and economic viable interventions at different urban levels (buildings, city/neighbourhood), covering all relevant aspects of the heritage-built environment’s life cycle: (1) Design and renovation; (2) Monitoring, operation and management; (3) Preservation and maintenance. The solutions will be tested in 8 cultural heritage sites across EU. In addition, INHERIT will create a capacity building programme addressing heritage operators and stakeholders (including large companies, SMEs, public authorities, research organisations and citizens) to support sustainable CH with particular focus on NEB community and projects and will work on policy recommendations towards sustainable heritage.

Keywords: cultural heritage,energy efficiency,climate resilience,inclusiveness,sustainability
Development of innovative proton and neutron therapies with high cancer specificity by 'hijacking' the intracellular chemistry of haem biosynthesis. (NuCapCure)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway,Spain,Czechia,Germany,Greece,Netherlands
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-02-01
End date: 2028-07-31
Duration (months): 54.0
Total project cost (EUR): 5972875.75
EU funding (EUR): 5972875.75
Participants: 8
Project status: SIGNED

Deep-lying cancers, such as glioblastoma multiforme (GBM) brain cancer, are very difficult to access and incurable by the current standards of care. The fluorescence of photosensitive molecules (PSs) can precisely guide surgical resection of GBM. Nevertheless, photomedical treatments like photodynamic therapy (PDT) show limited efficacies due to the low penetration of light into tissue. Proton radiotherapy can reach deep-lying disease through therapeutic energy deposition in a spatially confined region called Bragg peak. Current neutron-based therapies, like Boron Neutron Capture Therapy (BNCT), have sufficient penetration depth but lack cancer specificity. In NuCapCure, we propose to 'hijack' intracellular biosynthetic pathways and use them to produce custom-made drugs that will facilitate two genuinely new cancer treatments: i) "NuCapCure Proton", combining proton radiotherapy, protondynamic therapy through PS proton activation, and proton capture therapy (BPCT) through three produced alpha particles; and ii) "NuCapCure neutron", combining GBM specific BNCT and PS neutron activation as demonstrated in our FET-open project FRINGE. The main scientific breakthroughs of NuCapCure will be to demonstrate the custom production of novel compounds through native intracellular biosynthesis but also to establish experimental proof-of-principle, both in vitro and in vivo, of the proposed two novel therapies. Our highly interdisciplinary project team comprises world-renowned experts from a unique combination of disciplines: proton and neutron physics, synthetic chemistry, photochemistry, photobiology, radiobiology, medical physics, nuclear reactor and particle accelerator technology and radio-oncology to lay the foundations for novel, targeted and curative therapies against currently fatal cancer indications like GBM.

Keywords: proton therapy,boron neutron capture therapy,photobiology,photomedicine,medical physics,5 ala,protoporphyrin ix,glioblastoma,boron proton capture therapy,protondynamic therapy
dYnAmic resource scHeduling in Massive MIMO based NOMA with RF imperfections and EnergY hArvesting for 6G networks (YAHYA-6G)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: SIGNED

YAHYA-6G aims to propose new signal processing solutions doped with machine-learning. We will focus on the detection and compensation of RF imperfections in mMIMO (massive Multiple input Multiple output) based NOMA (Non-orthogonal multiple access) pair . In other hand, YAHYA-6G target is to minimize the long-term power consumption based on the stochastic optimization theory for mMIMO-NOMA IoT networks with EH (Energy Harvesting) in presence of RF imperfections. Thus the objectives of the YAHYA-6G project are: 1- Identify major RF imperfections that may occur in a multi-access / multi-antenna broadband system. 2- Propose new solutions to optimize the energy efficiency at the RF transmitters. This solution will focus on the power amplifier that represents 60 at 70% of the energy consumed in an RF transmitter. 3- Analyze the impact of these RF imperfections on mobile radio systems exploiting NOMA technologies. 4- Propose a Deep Learning online learning process to detect the NOMA channel characteristics and compensate the effect of HPA nonlinearity. A joint detection of the NOMA interference and HPA (High Power Amplifier) nonlinearity will be studied in mMIMO-NOMA system. 5- Resolve a non convex based problem coping with the expected 6G requirements, with a particular focus on optimal resource scheduling and computation capacity allocation and reducing energy consumption of wireless devices, through a set of new algorithms . 6- Realize a demonstrator based on the SDR (Software Defined Radio) USRP cards on which some algorithms developed in the project will be implemented.

Keywords: massive mimo,eh,noma,rf imperfections
Regulatory frictions as spaces of innovation (FRICTIONS): Centring the transformative administrative practices of small-scale cultural initiatives as empowering tools to engage with the climate crisis (FRICTIONS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Belgium,Australia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-07-31
Duration (months): 22.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 4
Project status: SIGNED

FRICTIONS investigates the substantial gap between European policy commitments for a climate-neutral economy, and the reality on the ground for small initiatives across Europe, who are making transformative endeavours for climate action in their own communities, but face regulatory systems that do not fit the visionary work they do. FRICTIONS engages with this impasse at a practical level, through the day-to-day practice of administration as a place where new, innovative procedures, relations and ways of thinking about regulation can be imagined and forged. The research approach departs from notions of progress and modernity that characterise much of transition discourse, to concentrate instead on systems change at the micro-level of habit, everyday process and experience – with particular focus on procedural spaces and relationships where things often feel stuck. Drawing on my research practice as an artist-activist working across art, business and social fields, the research objectives are to 1) unearth, illuminate and negotiate the kinds of regulatory frictions that small, sustainably-minded organisations regularly encounter and the innovative actions they are already making; 2) design creative experiments in administrative practice for how such organisations can prefiguratively navigate complex regulatory systems across different EU jurisdictions; and 3) establish new channels, procedures and vocabulary to promote innovative administrative practice as a transformative means to strengthen and sustain culture-led innovation for the EU's critical ecological transition. To achieve these objectives, FRICTIONS will engage methods from participatory action research and tactical art, working collaboratively with 3 exemplary small-scale cultural initiatives (NL/SI/HR), and establish a new research centre, the Institute for Experiments with Business (IBEX), as a platform to continue this work beyond FRICTIONS.

Keywords: artistic research,socio cultural aspects of ecological transition,critical management studies,feminist economic geography,diy culture,organising for sustainability
AIR AND NOISE POLLUTION MITIGATION THROUGH INTEGRATED, SOCIETY-CENTRED ACTIONS (ATMOPOLIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Research and Innovation actions
Countries involved: Finland,United Kingdom,Poland,Austria,Norway,Ireland,Spain,Bosnia and Herzegovina,Montenegro
Call: Zero-pollution cities (HORIZON-MISS-2024-CIT-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4999715.25
EU funding (EUR): 4999715.25
Participants: 14
Project status: SIGNED

Air and noise pollution regularly exceed recommended limits in Europe, with significant public health burdens, particularly for the vulnerable. Reducing pollution not only benefits population health but can have co-benefits for reducing carbon emissions and mitigating climate change. Urban pollution is a complex challenge requiring integrative solutions that combine comparative evidence of the impact of measures on pollution reduction and health, with an understanding of their social and economic, and systemic implications. Ambitious change will require that solutions and actions across multiple scales (city/citizens). ATMOPOLIS addresses the combined effects of air and noise pollution in European cities, identifying optimal solutions and supporting top-down (city/region) and bottom-up (community/people) action to achieve aligned pollution and climate mitigation goals. The project will: 1)Assess time-integrated monitored air and noise pollution exposure for specific individual groups, linked to their perceptions, culture, and behavior through personal narratives. 2)Model high-resolution population air pollution and carbon emissions (EU Mission and Green City Accord cities) and derive novel metrics of population noise pollution from community data and models (ATMOPOLIS partner cities) under existing and mitigation scenarios. 3)Evaluate health and wellbeing impacts of exposure under these scenarios, including for vulnerable groups, and identify the social determinants that increase risk. 4)Develop an evidence-driven integrated decision-making tool that identifies optimal cost-effective top-down policy actions by cities; and use persuasive design approaches to leverage emerging digital pollution platforms to support bottom-up change and empowerment. 5)Using system dynamics models and the integrated tool as a framework, co-create with cities informed policy pathways to meet zero pollution and carbon neutrality goals and improve population health and wellbeing for all.

Keywords: air pollution,noise pollution,health impact assessment,photovoice,participatory methods,systems thinking,community based monitoring,climate change,pollution mitigation,policy support
Extremophile cyanobacteria as life supporters for Mars colonization (MarCyan)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2026-02-28
Duration (months): 28.0
Total project cost (EUR): 186331.16
EU funding (EUR): 186331.16
Participants: 1
Project status: SIGNED

The curiosity and the interest of Humanity in space exploration lead to important discoveries on fundamental questions about our place in the Universe, and push forward the development of new technologies, new industries, and important international relationships. Mars is the nearest planet to Earth, has evidence of water, an element essential for life, and a geological history similar to Earth. These characteristics turn it a source of inspiration and a possible home for humans in the future. However, it is an inhospitable place and several solutions are being pursued in order to help terraform the planet. Atmospheric composition, cosmic radiation, temperature, and the lack of a protective magnetic field are just a few of the problems that Humankind needs to face prior to considering Mars colonization. However, there is a group of organisms that can be used to help solve some of the problems – Cyanobacteria. Why? Because they are simple oxygen producer organisms, with low nutritional requirements, and able to live in a wide range of extreme conditions and ecosystems. Moreover, cyanobacteria can also be used as food sources, to produce biofuels, in bioremediation, and as biofertilizers, for instance, and already proved to be good candidates for the task. MarCyan has the major goal of investigate the possible use of cyanobacteria to support Mars exploration. How? Using extremophile cyanobacteria, isolated from a Mars analog site (Rio Tinto, Spain), and submitted to Mars-like conditions in specialized Planetary Simulation Chambers. Moreover, MarCyan intends to go beyond the conventional knowledge and will use transcriptomic and metabolomic analysis to uncover the possible mechanisms that can help to explain the survival of these organisms to extreme conditions, opening the door to a more conscious choice of the best organisms to be used in Space exploration.

Keywords: astrobiology mars cyanobacteria extremophile planetary simulation chambers
EPIHERD is a comprehensive ML and AI-enhanced RNA analysis platform for optimising livestock health and productivity. (EPIHERD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The global surge in population, and dairy consumption poses an imminent threat to sustainability, amplifying environmental challenges such as deforestation and emissions. In the EU, a decline in dairy farms, coupled with impending regulatory constraints, projects a 13% reduction in the dairy herd by 2035. Antler Bio identifies an unmet need in addressing these challenges by delving into the unexplored realm of epigenomics in the livestock sector. Antler Bio's groundbreaking Epigenomics-AI Herd Screening platform, EPIHERD, pioneers a novel approach to enhance dairy productivity sustainably. By integrating gene expression profiling and RNA-sequencing, EPIHERD provides dairy farmers with unprecedented insights into their herds. Recognizing that genetics alone explain only 30% of traits, this innovation transcends the traditional focus on genetic code variance, offering 99.7% accurate recommendations to boost farmer profits, enhance resilience, ensure animal welfare, and mitigate greenhouse gas emissions. Antler Bio's EIC project outlines strategic milestones. Longitudinal sample collection, phenotypic metadata gathering, and automation optimization precede the expansion of machine-learning algorithms and biostatistical analysis. The project culminates in field testing, user feedback, independent validation, and the establishment of an augmented lab and biobank in the UK, aligning with Antler Bio's commitment to meeting the escalating demand for sustainable dairy practices.

Keywords: epigenetics,gene expression,livestock,ai,ml,sustainability,farming,rna analysis,platform,dairy cows,animal
Nanotechnology and advanced materials for a sustainable and safe Europe (EuroNanoForum 2023)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Coordination and support actions
Countries involved: Sweden
Call: Presidency event (conference) in Sweden: EuroNanoForum 2023 (HORIZON-CL4-2022-SWEDEN-CONF-IND-IBA, 2022)
Start date: 2023-01-01
End date: 2023-08-31
Duration (months): 8.0
Total project cost (EUR): 370075.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Nanotechnology and advanced materials play a major role in our society providing the underlying functionality to a wide range of devices, machinery, and services used daily by citizens, industries, businesses, health care and government. As a result, the continued development and implementation of these technologies are a key guarantee for sustainability and improvement of the lives of the people in Europe. Advanced materials and nanotechnology are central in development of new energy technologies, are the basis of the hardware of the digital and information society and will be crucial in establishing a circular economy significantly decreasing our environmental footprint. This affects the European Green Deal, Europe fit for the Digital age and an economy that works for people. EuroNanoForum 2023, to be held on 11–13 June 2023 in Lund, Sweden, is a conference of a major strategic nature that is focused on identifying policy options and priorities and on planning future actions regarding European activities on advanced materials, nanotechnology, innovation, sustainability, circular economy as well as materials and fossil-free energy. This will be achieved by combining the collective effort of actors encompassing innovation, research, industry, public authorities, investors and civil society. The event will examine the role of nanotechnology and advanced materials in contributing to cross sectorial industry challenges and solutions for boosting the economy through clean technology and making the EU's economy sustainable and resilient to future crisis. As an outcome, the event will supply innovate solutions and common lines of action to address both, present challenges of energy and supply crises and to use lessons learned in the present day to prepare Europe to solve long term challenges of climate change and environmental degradation while making the transition just and inclusive for all.

Keywords: conference during presidency,advanced materials,innovation,circularity