Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ocean DYNAmics reconstruction using remotely sensed variables in two CLIMate hotspots (DYNACLIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-16
End date: 2023-04-13
Duration (months): 36.0
Total project cost (EUR): 259398.72
EU funding (EUR): 259398.72
Participants: 1
Project status: CLOSED

By transporting heat and energy, ocean currents play a major role in shaping the climate of Earth’s many regions. However, characterization of ocean dynamics remains one of the key problems in oceanography. This project addresses the reconstruction of ocean currents from satellite observations. Using two semi-analytical quasi-geostrophic models and proposing a new numerical approach, this proposal aims to exploit the available spatiotemporal sampling capacity of remotely sensed salinity synergistically with sea surface temperature and sea surface high to reconstruct the ocean three-dimensional dynamics. This approach will be applied to the Arctic Ocean and the Mediterranean Sea; two regions of relevant importance in order to better understand the consequences of climate change and where enhanced satellite salinity products are recently being produced. Reinforcing knowledge both on the Mediterranean and Arctic dynamics represent a community priority as they represent key navigation areas, the Mediterranean Sea for its actual navigation transit and the Arctic Ocean if the near future makes ice melting worst predictions a reality and the possibility to navigate through the Northern Pole opens. Moreover, improving the circulation understanding in these areas would also contribute to European politics to reduce the climatic impact of maritime transport contamination.
Neurofilaments in Health and neurodegenerative diseases (NeuroFish)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1874863.0
EU funding (EUR): 1874863.0
Participants: 1
Project status: SIGNED

Neurofilaments (NFs) are a highly dynamic cytoskeletal network, which exhibits essential functions in neurons and are key actors in neurodegeneration. NFs are not only a genetic cause of neuronal death in human, their abnormal aggregation is an early pathological hallmark in disease, and their genetic removal from axons has shown spectacular benefits in delaying disease onset, extending survival and restoring neurological functions in mouse models. In this project, I propose the concept that the defects in NF transport and degradation are the causes of neurodegeneration. I will tackle the live dynamic of these processes in health and disease in a meaningful in vivo context, using the zebrafish. Combining state-of-the-art and innovative live-imaging and proteomic methodologies in zebrafish, our program has three major goals. First, we will study the dynamic of NF transport along the axons and its spatial regulation by myelinating cells, with novel zebrafish lines expressing fluorescently labeled NFs. Second, we will decipher the mechanisms of NF degradation by generating a zebrafish line overexpressing gigaxonin, an E3 ligase adaptor we found to destroy the stable NF network, and by designing a new proteomic methodology in zebrafish. Finally, we will investigate NF dysfunctions and their pathological roles in disease, by generating models for neurodegenerative diseases carrying NF mutations and using the methodologies described above. I anticipate that interventions on NF dynamics will substantially reverse neurodegeneration, and proofs of concept will be obtained by overexpressing gigaxonin in our disease zebrafish models and through drug screening. Thus, this ERC project will generate forefront knowledge in the field of NFs and neurodegeneration and will provide a highly significant platform for therapeutic intervention on NFs, for the benefit of most neurodegenerative diseases.

Keywords: neurofilaments,zebrafish,charcot marie tooth type 2 diseases,cmt2
Transient micromachined pressure-monitoring implants for chronic brain disorders (BrainWatch)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 157355.52
EU funding (EUR): 157355.52
Participants: 1
Project status: CLOSED

Millions of people worldwide are living with chronic brain disorder causing direct and indirect cost of 100s of billion euros for health budgets. Majority of this cost incurs during the treatment and can be eliminated by developing tools to monitor critical parameters after patients are discharged from hospital settings. Because of the absence of such technology, abnormal changes cannot be detected until the opportunity to prevent further damage to the brain has passed. Recently developments in micromachining and biodegradable materials have revolutionized sensor and drug delivery/stent industry. Advances in micromachining can be combined with the unique features of biodegradable materials to realize transient implants that do not pose infection or inflammation risk and does not require an extraction surgery. The objective of this proposal is to design, fabricate and characterize transient micromachined pressure monitoring implants capable of wireless communication for brain disorders. This technology will allow continuous monitoring outside hospital settings and development of personalized and preventative treatments which aligns with the Horizon2020 health goal of providing more effective and timely therapies. Combining biodegradability to micromachined sensors comes with challenges and limitations in design, fabrication and integration, which this proposal aims to overcome with novel approaches. Dr. Levent Beker’s expertise in micromachined and flexible sensor development combined with the expertise of the supervisor and collaborators in nano-patterning, biodegradable materials, wireless communication and neurosurgery will help to accomplish goals of the proposal. This two-year fellowship at Koc University, TR with, a secondment at ETH Zurich, CH, will help Dr. Beker to expand his scientific skill sets, develop research management skills to become an independent researcher while effectively transferring experience to host institutions.

Keywords: mems,transient,biodegradable,pressure sensor,neural disorders
Associating Literature and the Imaginary with Science: Early Years Education (ALIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2017-07-31
Duration (months): 18.0
Total project cost (EUR): 146591.1
EU funding (EUR): 146591.1
Participants: 1
Project status: CLOSED

Our project fits into the narrative movement in scientific literacy but defends a different position with regard to children’s literature in science. We do not see a division between science and literature but rather a fertile convergence between the construction of a storyline and the activity of scientific “problematization”, a process at the heart of scientific learning. We believe that reading certain fictional narratives offers a conductive environment for engaging young children in scientific questioning. The meaning of the fictional narrative arises from the conflict between the elements of fiction and the elements of reality, between what is within the realms of possibility and what reflects the truth. In contrast, it is through fictional events that natural world phenomena can be questioned. Stories invent a “possible world” which forces the reader back to knowledge of the real world in order to understand it. Following Bruner, we attribute an epistemic aim to some fictional narratives. This project seeks to understand how pupils aged 3-11 years get involved in science within and outside school based on the reading of fictional picture books with the aim of giving teachers the means to develop integrated teaching systems (science and literature): to what extent does reading fictional storybooks lead children to test their representations of the animal world, and more specifically metamorphosis? We will work with a body of “realistic fiction”-type children’s storybooks that bring into play the idea of metamorphosis. We will identify the literary sources to which pupils aged between 3-11 years refer spontaneously when they talk about animal transformations. We will analyse the mechanisms which give rise to the children’s questioning about the metamorphosis of animals as well as comprehending the nature and coherence of this questioning with regard to the stories themselves.

Keywords: early years education,science education,metamorphososis,biology,fictional storybooks
Open Participatory Engagement in Collective Awareness for REdesign of Care Services (OPENCARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Sweden,France,Netherlands,United Kingdom
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 1588563.75
EU funding (EUR): 1588563.75
Participants: 6
Project status: CLOSED

OpenCare prototypes a community-driven model of addressing social and health care, and explore its implications at scale. It draws on three elements: advances in collective intelligence research, to lend coherence and summarize large-scale online debates; advances in digital fabrication and cheap-and-open hardware technology; and the rise of a global hacker community, willing and able to look for solutions to care problems. We explore the potential of this approach to deliver innovative, human-centric care solutions that combine the low bureaucratization and low overhead of communities with the scientific knowledge and technical skills associated to state- and market-provided professional care. OpenCare orchestrates an open-to-all, community-driven process for addressing care issues, recruiting its participants from existing communities innovating at the edge of society (among others, hackers, artists, activists, designers). This entails the complete design cycle of sensemaking => selection of a problem-solution pair => prototype => testing => evaluation at scale; each step of the cycle will be radically open, with the debate happening online and the fabrication happening in hackerspaces and fully documented. We release open data and deploy onto them state-of-the-art analytical tools for collective intelligence: online ethnography and social network analysis. We integrate these two approaches into a semantic edges analysis approach. We expect two main types of impact. The first: contributing to a better understanding of how to deploy the collective intelligence of smart communities onto sustainability problems. The second: contributing to the debate on reforming care provision in Europe by exploring how community-driven care services might integrate in the existing European care policy landscape. OpenCare is delivered by a diverse consortium drawn from Europe’s best universities and the grassroots hacker community.

Keywords: care,welfare,service design,open design,open hardware,open data,public policies,participation,online communities,collective intelligence,social network analysis
Solar Energy for Carbon-Free Liquid Fuel (Sun-To-X)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,Belgium,France,France,France,Netherlands,United States
Call: Converting Sunlight to storable chemical energy (H2020-LC-SC3-2019-NZE-RES-CC, 2019)
Start date: 2020-09-01
End date: 2024-02-29
Duration (months): 42.0
Total project cost (EUR): 3096643.75
EU funding (EUR): 2999143.75
Participants: 9
Project status: SIGNED

The Sun-to-X project will contribute to European Commission targets for clean energy for all and circular economy by developing a system for the conversion of solar energy into storable chemical fuel. While the concept of solar-to-chemical fuels has been around for decades, the technology has been limited by the economic viability and scalability of the technology. The Sun-to-X project focuses on using solar energy to produce a carbon-free, non-toxic, energy-dense, liquid fuel - Hydrosil, with very good long-term stability, which is applicable in the transport and energy sectors. We will firstly produce hydrogen as chemical intermediate through a photoelectrochemical device. This will then be converted to Hydrosil through a thermochemical reaction. The novelty of our proposal lies in the following three key aspects: 1. Overcoming the known practical challenges of high-performance photoelectrochemical fuel production by using membrane photoelectrode assemblies which can operate with solar energy using only ambient humidity as the water supply 2. Developing reactors for and demonstrating the renewable production of Hydrosil for the first time, using a thermochemical process (using concentrated solar light) 3. Demonstrating a completely decarbonised energy cycle with liquid fuels In addition, we will demonstrate the applicability of Hydrosil towards the transition to a circular economy, by using it for the valorisation of waste plastics.

Keywords: solar energy,solar fuels,decarbonisation
Bringing flexible organic electronics to pilot innovation scale (PI-SCALE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Finland,Czechia,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Cross-cutting ICT KETs (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2019-06-30
Duration (months): 42.0
Total project cost (EUR): 15689177.76
EU funding (EUR): 13999792.76
Participants: 15
Project status: CLOSED

“Bringing flexible organic electronics to pilot innovation scale” (PI-SCALE) is a highly needed response to bridge the gap which exists today between promising laboratory scale results of highly efficient flexible OLED modules and mass manufacturing of high value-added products. The project will integrate existing European infrastructures into a “European flexible OLED pilot line”, which will operate in an open access mode and serve customers from along the value chain with individual product designs, validation of upscaling concepts, and system-level flexible OLED integration. The Consortium will connect the most advanced pilot line facilities with the best material providers and equipment manufacturers, creating a service that will offer substantial numbers of flexible OLEDs that can meet efficiency, durability and cost requirements of end users. Together with end-users for various markets, such as automotive and designer luminaires, PI-SCALE will demonstrate the capabilities of this pilot line doing process optimisation for product demonstrators to enable cost efficient production and facilitate an effective market introduction. In addition PI-SCALE will include a number of outreach activities to actively engage and educate interested users and suppliers for flexible OLEDs in interactive product concept development. PI-SCALE will not only support the market acceptance of flexible OLED products, but it will also ensure that prototype ideas from European companies will have the possibility of reaching a semi-industrial scale in a very short time.

Keywords: oled,flexible,pilot line,lighting,displays,automotive,electronics
Unraveling complex organ regeneration through live imaging and molecular profiling approaches (reLIVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 2571694.0
EU funding (EUR): 2571694.0
Participants: 1
Project status: CLOSED

Many animals have the ability to regenerate parts of their body following injury or amputation. While there is great biological and medical interest in this process, many fundamental questions remain unanswered, because complex organ regeneration is poorly represented in classic model organisms; flies, nematodes and mammals have limited regenerative abilities, in contrast to flatworms, crustaceans and fish. reLIVE explores fundamental questions on regeneration in an emerging crustacean model, Parhyale hawaiensis, which combines extensive regenerative abilities, advanced genetic tools and live imaging. The project will address the following fundamental, centuries-old questions on regeneration: 1) Which are the progenitors that underpin complex organ regeneration? Do epidermis, tendons, neurons, glia and muscle arise de novo from undifferentiated adult stem cells, or do they emerge from differentiated cell types? Are the progenitors unipotent/committed or multipotent? Which are their molecular responses and behaviors during the course of regeneration? 2) Do diverse animal groups regenerate in the same way? Do the regenerative progenitors of crustaceans have common molecular and functional properties with those of vertebrates and flatworms? Do they have a shared evolutionary history? 3) How does regeneration differ from development? Are these processes operating on comparable temporal and spatial scales? How similar are the transcriptional responses and cell behaviors that underpin embryonic and regenerative morphogenesis of the limb? To answer these questions, reLIVE will take advantage of the unique opportunities offered by Parhyale limb regeneration and, for the first time, combine four cutting-edge approaches: a) CRISPR-mediated marking of specific cell types, b) continuous live imaging and cell tracking in regenerating limbs over week-long periods, c) a novel method of cell lineage reconstruction, and d) transcriptional profiling on individual cells.

Keywords: regeneration,comparative developmental biology evo devo,emerging model organisms,live imaging,cell lineage,molecular profiling
Development of a cell-based system for high-throughput screening of antifibrotics (CollBioImag)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Liver fibrosis (hepatitis B and C, cirrhosis, etc) represents an enormous health burden responsible for ~1.03 millions death per year worldwide according to the World Health Organization. Fibrosis is also a common outcome of many chronic diseases of the kidney (diabetic nephropathy), lungs (idiopathic pulmonary fibrosis), heart and vasculature (heart failure). In pathologies where fibrosis is a feature, there is an increased deposition of extracellular matrix proteins, including collagens that dramatically limit tissue function. Herein we propose to develop a cell-based assay for high-throughput screening of new antifibrotic therapeutics, which will accelerate fibrosis drug development. Our approach consists in the metabolic incorporation of an alkene-tagged proline in the biosynthesis of collagen, followed by labelling with a fluorescent tetrazine. We recently published preliminary results that provide proof of principle for the use of proline derivatives equipped with reactive handles to tag and label collagen structures. However, this approach suffered from nonspecific reactions of the fluorescent probe with intracellular proteins. The level of selectivity conferred by the proposed inverse-electron-demand Diels-Alder reaction is key in enabling its use in cells. We will use hepatic stellate cells since these cells are responsible for excess collagen production during liver fibrosis. To demonstrate that the cellular model can be used to screen compounds for fibrosis we will validate our system using a library of compounds with known preclinical antifibrotic activities. We will test if their in vivo efficacy can be predicted using cells. If our findings are significant we will use this cellular model to screen a commercial available library of compounds to find new antifibrotic drugs. The efficacy of the best candidate will be tested in vivo using two animal models of induced fibrosis.

Keywords: fibrosis,collagen,bioorthogonal,diels alder,alkene,tetrazine,antifibrotics,high throughput screening