Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechano-Regulation of Proteins at Low Forces: Paving the Way for Therapeutic Interventions (ProForce)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-03-01
End date: 2027-02-28
Duration (months): 60.0
Total project cost (EUR): 1991760.0
EU funding (EUR): 1991760.0
Participants: 1
Project status: SIGNED

Mechanical forces play critical roles in the regulation of biological functions, including development, motility, and haemostasis. Aberrant mechano-regulation is implicated in human pathologies, including cancer and infarction. Proteins sense forces by undergoing conformational changes under external loads that trigger downstream signaling. Despite its importance, mechanical regulation at the single-protein level remains poorly understood, in part due to a lack of suitable techniques to probe the physiological highly relevant low force (~1 pN) range. ProForce aims to understand mechano-regulation at the single-molecule level in this previously inaccessible regime and to develop approaches to directly interfere with and correct aberrant force responses. We propose to advance massively-parallel magnetic tweezers as the ideal tool for single-protein force measurements, as they can resolve very small forces (<0.1 pN), perform stable and highly-multiplexed measurements over long times, and can readily be combined with fluorescence detection to provide an orthogonal read out. We aim to address three sets of biological systems that are regulated by low forces and are potential targets for drugs that alter their force response: 1) The blood protein von Willebrand factor (VWF) that is activated by shear flow and critically involved in haemostasis. Reduced VWF activity leads to bleeding disorders, while gain-of-function mutations increase the risk of myocardial infarction. 2) Focal adhesion kinase is a force-activated kinase involved in intracellular signal transduction pathways important in cell proliferation, migration, and metastasis. 3) Adhesion G-protein coupled receptors are a subset of the GPCR-family, activated by mechanical stimuli and involved in development, immunity, neuronal function, and tumorigenesis. The aim of ProForce is to understand mechano-regulation at the single-protein level and to establish force response as a potential drug target.

Keywords: protein conformational changes,forces,force spectroscopy,magnetic tweezers,von willebrand factor,focal adhesion kinase,adhesion gpcr
INCORPORATE sustainable structures for Energy Efficiency projects in Austrian Smart Cities (IncorporatEE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Austria,Austria
Call: Aggregation - Project Development Assistance (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2022-03-01
End date: 2026-02-28
Duration (months): 48.0
Total project cost (EUR): 1583451.25
EU funding (EUR): 1583451.25
Participants: 6
Project status: SIGNED

IncorporatEE project aims to realise EUR 60 million of total investments (EUR 32 million in energy-related measures) in major renovations, improvement of building services and installation of renewable energy sources in public buildings in the city of Salzburg and Villach. These savings will not only be calculated at the design stage, but will be guaranteed by an innovative quality management process up to commissioning. In this way, energy savings of 55% and CO2 savings of 65% can be achieved in building operation during comprehensive renovations, which means an increase of around 30 percentage points compared to previous renovations. In order to achieve this goal, it is necessary to turn not just one but many set screws. The new Performance-Based-Renovation-Package (PeBaRePa) is the sum total of these set screws for renovations. This package is designed to ensure the implementation of performance-based objectives all the way through to operation. This package comprises the following components: - Establishment and training of a dedicated organisational unit in the cities responsible for implementing energy performance quality assurance - Developing internal financing models within the city in order to be able to finance investments in energy-efficient renovations in the long term - Development of innovative, performance-related contracts for planners to provide financial incentives to plan and implement high energy performance - Development of a catalogue for sustainable refurbishment of public buildings specifically for the requirements and specifications of the participating cities - Development and adaptation of a quality assurance process from planning to commissioning of buildings - Development of business models for energy communities for photovoltaics during roof refurbishment The PeBaRePa will be disseminated nationally and internationally to public authorities as well as to planners and developers.

Keywords: energy efficient refurbishment,performance bases renovation,incentives for planner contracts,energy efficiency criteria catalogue,renewable energy communities
Submersible Tension Leg Fish Cage for Mariculture in Unsheltered and Offshore Areas (SubCage)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Italy
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Aquaculture has done reasonably well to supplement the expanding consumption of fish and seafood in the EU but has still been unable to have the desired impact because of the high set up, operating and maintenance costs; lack of space along the coastal shores; pollution and threats of diseases and eutrophication. Hence, we developed SubCage – a working proof of concept prototype to TRL 6 which is based on a patented Tension Leg Cage (TLC) technology capable of submerging fish cages to depths of up to 55 m at a controlled velocity based on the principle of wave ispersion. This prototype is a 12 m diameter fully submersible fish cage, which has been tested for 2 years in Crete using red porgy. This was successfully demonstrated as there were no issues during the operation and thus confirmed that SubCage satisfies all customer needs, such as: cost benefit solution for fish farming in unsheltered area; increase of fish quality; improvement of fish health and mortality rate. Despite the risk surrounding aquaculture in the unsheltered regions due to its environment; we proved that, by using SubCage, expanding production capabilities in such areas is feasible, commercially beneficial to farmers and can increase the value of the fish species. With the help of the SME instrument in scaling up our prototype to a 30-55 m diameter commercially acceptable fish cage, we would expect to contribute to an increase in fish price of up to 20% and additional increase in yield of up to 2% in comparison with surface cages. In comparison with competitor technologies, our prices will be several times lower by 30-40% as well as an estimated ROI being achievable in approximately 3 years. Within 5 years, we can humbly anticipate to enhance the production capacity of the EU by 2%. This translates to Refa Med Srl. deploying 402 SubCage units in the EU within 5 years, generating a revenue stream of over €80 million and helping create between 300 and 400 product-related full-time jobs.

Keywords: submersive,fish cage,mariculture,offshore
NanoOptoMechanics in classical and quantum Liquids (NOMLI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2025-03-31
Duration (months): 84.0
Total project cost (EUR): 2292068.28
EU funding (EUR): 2292068.0
Participants: 1
Project status: SIGNED

Over a decade, the field of optomechanics has progressed to the point of enabling first quantum experiments on mesoscopic mechanical devices. This maturity culminates with nanoscale semiconductor systems, which operate at very high mechanical frequency and allow intense interaction between light and mechanical motion. On top of representing a new class of elementary quantum systems, nano-optomechanical devices can sense forces at small scale with high speed and resolution, down to the quantum limit. They could probe physical interactions in complex environments, like liquids, with a unique degree of control, and thus bring new science and applications. NOMLI explores original physics at the interface of nano-optomechanics and liquids, be they classical or quantum. A first objective is to realize nano-optomechanical rheological measurements at very high frequency (GHz) and small scale (μm) in classical liquids, and investigate the solid-like behavior of liquids in previously inaccessible regimes. A second objective is to optically cool a nano-optomechanical resonator immersed in a classical liquid down to the quantum regime, and analyze mechanical decoherence in such complex environment. As third objective, a quantum liquid of light will be artificially created in a set of nonlinear photonic resonators. Its viscous force will be investigated nano-optomechanically, and monitored as the liquid undergoes the superfluid transition. Finally a new type of quantum liquid, fully optomechanical in nature, will be formed in an ensemble of resonators at ultra-low temperature. Viscosity, dynamics and superfluidity of this new phase of light and matter will be investigated, using engineered photon-photon interactions mediated by mechanical motion. NOMLI will build a detailed picture of physical mechanisms at play, at the quantum level and at small scale, when a miniature mechanical force probe evolves in a liquid, where chemical and biological processes usually take place.
Enhancing Healthcare with Assistive Robotic Mobile Manipulation (HARMONY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Switzerland,Sweden,Sweden,Netherlands,Netherlands,United Kingdom,Portugal
Call: Robotics in Application Areas and Coordination & Support (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 7191613.75
EU funding (EUR): 7191613.75
Participants: 10
Project status: SIGNED

Harmony will enable robust, flexible and safe autonomous mobile manipulation robots for use in human-centred environments by making fundamental contributions in cognitive mechatronic technologies. Our targeted application area is assistive healthcare robotics, which is motivated by the mounting pressure on our healthcare system due to factors such as Europe's ageing population. While this presents an immense challenge for the healthcare industry, it is also an opportunity to proactively meet these challenges. Our current robotic automation solutions only offer “islands of automation” where either mobility or manipulation is dealt with in isolation. Harmony aims to fill this gap in knowledge on combining both robotic mobility and manipulation modalities in complex, human-centred environments. Harmony considers two use cases identified by our end user partners: 1) the automation of just-in-time delivery tasks; and 2) the automation of hospital bioassay sample flow. These use cases highlight existing processes that require fast, reliable and flexible automation to undertake the dull and repetitive tasks that are currently conducted by over-qualified staff. Critically, these tasks require robots that can interact with the world across a wide operational spectrum, from the (sub)millimetre precision required for fine manipulation to navigating across building- and campus-scale spaces. This motivates a holistic representation of the environment that facilitates the tight integration of socially aware planning, perception and control, and allows cognitive elements such as learning, reasoning and adaptation of actions for natural interaction. Harmony gathers the required expertise to tackle these core scientific and engineering challenges. Through demonstrators and open software modules, Harmony will show that robotic mobile manipulation systems can integrate seamlessly into our existing processes and spaces to meet growing needs in the healthcare industry and beyond.

Keywords: cognitive mechatronics,mobile manipulation,collaborative robotics
Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen (U-PGx)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Spain,Germany,Italy,Greece,Slovenia,Sweden,Sweden,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Piloting personalised medicine in health and care systems (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 14936613.25
EU funding (EUR): 14936613.25
Participants: 22
Project status: CLOSED

Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy. The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and embedded into the patients’ electronic record) of a panel of important pharmacogenomic variants as a new model of personalised medicine. To meet this goal we combine existing pharmacogenomics guidelines and novel health IT solutions. Implementation will be conducted at a large scale in seven existing European health care environments and accounts for the diversity in health system organisations and settings. Feasibility, health outcome and cost-effectiveness will be investigated. We will formulate European strategies for improving clinical implementation of pharmacogenomics based on the findings of this project.

Keywords: pharmacogenomics,implementation
AErial RObotic System for In-Depth Bridge Inspection by Contact (AEROBI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Israel,Germany,Spain,Italy,Germany,Greece,Belgium,Greece,France,France,United Kingdom
Call: Robotics (H2020-ICT-2015, 2015)
Start date: 2015-12-01
End date: 2018-11-30
Duration (months): 36.0
Total project cost (EUR): 3584850.25
EU funding (EUR): 3080376.55
Participants: 14
Project status: CLOSED

The latest developments in low flying unmanned robots with arms and the associated fields of intelligent control, computer vision and sensors open the floor for robotic solutions, exploitable in the near term, in the field of inspection of difficult-toaccess areas of the civil infrastructure in general and bridges in particular. The latter infrastructure is ageing requiring inspection and assessment. Presently, bridge inspection is primarily done through visual observations by inspectors. It relies upon the inspector having access to bridge components via access equipment (ladders, rigging and scaffolds) and vehicular lifts (manlifts, bucket trucks and under-bridge inspection vehicles). This is uncomfortable and potentially dangerous for the inspectors, while it interferes with the traffic contributing to bottlenecks and congestion. The results of the inspection are used to structurally assess the bridge in a following step. AEROBI, driven by the bridge inspection industry, adapts and integrates recent research results in low flying unmanned robots with arms, intelligent control in robotics, computer vision and sensing, in an innovative, integrated, low flying, robotic system with a specialised multi-joint arm that will scan concrete beams and piers in a bridge for potential cracks on the surface or concrete swelling or spalling. In case the width of the above cracks exceeds given limits, it will measure distance between parallel cracks, while it will contact the bridge to non-destructively measure the depth of cracks and deformation. In case of concrete swelling or spalling it will also contact the bridge to non-destructively measure delamination and the diameter of the reinforcing steel bars. The above will provide input for a structural bridge assessment that will be automatically performed by the proposed robotic system. The latter system, which is expected to be exploitable in the short term, will be field evaluated and demonstrated at two actual bridges.

Keywords: low flying unmanned robot with arms for inspection by contact,robotic bridge inspection
Safety in NanOmaterials & NAnotechnology (SiNfONiA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal
Call: ERA Chairs (H2020-WIDESPREAD-2018-04, 2018)
Start date: 2019-06-01
End date: 2024-12-31
Duration (months): 67.0
Total project cost (EUR): 2498581.25
EU funding (EUR): 2498581.25
Participants: 1
Project status: SIGNED

The potential of nanomaterials and nanotechnology to improve the quality of life, to address society’s grand challenges and to contribute to economic growth and to sharpen the competitiveness of industry is now widely recognized, not only in Europe, but globally. Nanomaterials and nanotechnology offer substantial possibilities for improving the competitive position of the EU and for responding to key societal challenges. However, there is a need to ensure the safe development and application of nanomaterial and nanotechnologies and for finding reliable ways to predict the potential risks to health, food and environment of these materials and technologies . Due to the widespread use of nanomaterials, it is critical to identify any potential risks they may pose to human health or the environment. These current uncertainties surrounding nanomaterial risk mean that research is required into nanomaterial safety. Addressing these knowledge gaps will help to ensure that innovation in the rapidly developing area of Nanotechnology is not stifled by concern, but instead by determining risks associated with nanomaterials we can promote the safe, sustainable and responsible use of this technology. SiNfONiA aims at attracting and maintaining a high profile researcher (ERA Chair) and respective research team with excellent research capabilities in the nanosafety research domain. SiNfONiA will play as a catalyst to fully maximise the impact of the ERA Chair on the scientific excellence and research performance of the International Iberian Nanotechnology Laboratory (INL).

Keywords: nanotechnology,nanomaterials,nanosafety,nanocharacterization,nanotoxicity,health risks,exposure,predictive descriptors,increased research capacity,scientific excellence
The Aggregate Implications of Market Power (M-POWER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 1575000.0
EU funding (EUR): 1575000.0
Participants: 1
Project status: SIGNED

It has been long understood by economists that market power can negatively affect welfare by limiting output, stifling innovation, and introducing inefficiencies in the overall allocation of production. On the one hand, there is ample evidence from case-studies, that the presence of market power, in the form of explicit or implicit cartels and other practices of anti-competitive behavior, can lead to substantial damages to producers and consumers in a given market. On the other hand, very little is known about the broad cross- sectional and time-series patterns of market power across sectors, regions and countries. In addition, and perhaps more importantly, if market power is at all present, does it affect so-called aggregate outcomes in the product and factor markets? For example should the analysis of productivity growth and investment take into account the presence of market power, and does market power play a role in labor market outcomes, such as e.g. in the recently reported decline in the labor share across a variety of countries? This project aims to fill the gap in the literature by applying recently developed techniques to, first of all, systematically document markups, across firms in the entire economy, and secondly, to analyze the implications for producers and consumers in the economy at large, including both product and input markets. While the macroeconomic literature on misallocation has considered a variety of distortions that affect the allocation of inputs across plants, the project introduces an empirical framework to quantify the welfare loss from market power. Special attention is given to the impact on productive inefficiency. The overall aim is to better understand, and quantify, how market power affects the allocation of resources in the context of heterogeneous producers, and empirically quantify the trade-off of price and cost effects.

Keywords: market power,markups,aggregate outcomes,misallocation