Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Manufacturing technologies and equipment to produce low-cost PV bituminous-modified roofing membrane with full integration of high efficiency flexible thin-film silicon PV modules (PV-GUM)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Netherlands,France,France,Netherlands,France,Belgium,Switzerland,Germany
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2010-11-01
End date: 2015-04-30
Duration (months): 54.0
Total project cost (EUR): 10747879.44
EU funding (EUR): 6234346.0
Participants: 10
Project status: CLOSED

With millions of square meters of available flat roof surfaces with PV conversion potential, PV roofing membranes have a huge potential for mass deployment. However, currently, major issues still hinder this deployment: adhesives or barrier encapsulants of the existing flexible PV roofs don’t meet yet the same reliability as standard construction materials and BIPV is still expensive. The PV-GUM project aims at developing new manufacturing technologies and equipments which will produce a low cost highly efficient flexibly BIPV solar cell on a bituminous roofing membrane (thanks to their proven sustainability, bituminous membranes remain predominantly used for waterproofing flat roofs). The PV-GUM membrane should be very close to the usual bituminous roofing membrane in terms of size, installation process and quality to highly increase the penetration power of PV-GUM in the building market. The PV-GUM membrane will be based on the “Derbibrite” white-coated bituminous membrane technology of Imperbel, PV-GUM coordinator, and the Flexcell flexible PV modules technology. The full integration of the flexible PV modules in the membrane will be performed at the manufacturing stage by a new standardized roll-to-roll encapsulation process to produce PV-laminates followed by a roll-to-roll bitumen impregnation of the PV-laminates. In parallel, a new standardized PECVD reactor and process will be implemented to increase the Flexcell PV cells efficiency to 8% at least and achieve technology superiority over Unisolar remaining the main supplier for this market. The PV-GUM project targets a PV-laminates production capacity of 20 MW. The high degree of integration of the PV modules and the roll-to-roll lamination allowing process automation will highly decrease the costs /Wp. Furthermore, sustainability, quality procedures and monitoring in line, compliance to BIPV standards, as well as fully recyclability of the whole product are associated priorities of PV-GUM.

Keywords: bipv,pv roofing bituminous membrane,high efficiency thin-film tandem silicon,flexible solar modules,roll-to-roll encapsulation,wires bitumen pv recycling
Spatial and temporal regulation of the fungus-host interaction during life-threatening fungal infections (STRIFE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-05-01
End date: 2015-04-30
Duration (months): 60.0
Total project cost (EUR): 1799992.0
EU funding (EUR): 1799992.0
Participants: 1
Project status: CLOSED

The major fungal pathogen, Candida albicans, has a significant impact upon the health of the European population. Candida frequently causes oral and vaginal thrush, and life-threatening infections in intensive care patients. These infections drain European finances through lost working days and extended patient hospitalization. A major goal is to understand how this fungus interacts with its human host and how these interactions contribute to pathogenesis. This will enhance efforts to develop accurate diagnostics for systemic candidiasis. Candida pathogenomics has advanced rapidly in the last decade. Nevertheless, our understanding of fungus-host interactions remains rudimentary. Therefore, our Grand Challenge is to exploit advanced new tools to accurately capture the spatial and temporal regulation of fungal molecular responses in lesions during disease progression. My laboratory is uniquely placed to address this challenge using a powerful combination of new, state-of-the-art technologies. Laser capture microscopy, ultrasensitive microarray technologies and 2D-MALDI-ToF mass spectrometry will be used to define the C. albicans transcriptome and infectome, both spatially and temporally, across fungal lesions during disease progression. C. albicans infections will be imaged with a novel ultrasensitive reporter to confirm the dynamic regulation of specific cellular processes during disease progression. Then precise molecular tools will be used to establish the relative contributions of these processes to the infection process, and to explore candidate diagnostic targets identified during this programme. This will dramatically advance our understanding of fungus-host interactions and will identify potentially novel biomarkers of deep-seated systemic candidiasis.

Keywords: molecular medical mycology imaging of infections diagnostic tools
Component Performance-driven Solutions for Long-Term Efficiency Increase in Ultra Supercritical Power Plants - MACPLUS (MACPLUS)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Clean coal technologies
Action type: Collaborative project
Countries involved: Italy,Germany,United Kingdom,United Kingdom,Germany,Austria,Slovakia,Sweden,United Kingdom,Germany,Germany,Spain,Denmark,Spain,Finland,United Kingdom,Germany,Spain,Italy,Hungary,United Kingdom
Call:  (FP7-ENERGY-2009-2, 2009)
Start date: 2011-01-01
End date: 2016-06-30
Duration (months): 66.0
Total project cost (EUR): 19651044.2
EU funding (EUR): 10704674.8
Participants: 25
Project status: CLOSED

The intelligent and cost effective use of CCS technologies requires new strategies to increase the net efficiency of coal fired power plants. Among them, the most promising are summarised as below: - Increase working steam temperature and pressure in new USC power plants (350-370 bar, 700/720°C minimum), and hence increase the severity of fireside operating conditions, - Promote clean coal technologies based (for example) on oxy-combustion + co-firing technologies (by a continuous increase of biomass % in mixture with coal), in order to reduce CO2 capture losses and the amount of CO2 to be captured and stored. The project aims to increase the net efficiency of coal fired plants by increasing the performance and reliability of some critical components identified as follows: - refractory materials of the combustion chamber (especially for oxy-combustion application), up to 1800 °C - headers and pipework (avoidance of weld Type IV cracking phenomena, working temperature increase), up to 650-660 °C - super heaters (optimised performance in high temperature oxidation/hot corrosion environments), up to 720 °C - coated pipes and boiler components able to withstand co-combustion conditions (high temperature oxidation/hot corrosion, erosion-adhesion and wear), - HP and IP steam turbine rotor components and turbine casing up to 750-780 °C For each critical component, a full-scale prototype will be realised and installed into an industrial plant and/or in test loop(s) at known temperature, pressure and atmosphere conditions

Keywords: materials,long term efficiency,component performace,creep,creep fatigue
Primary immunodeficiency diseases as models for the study of the immune system (PIDIMMUN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: France
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-07-01
End date: 2015-06-30
Duration (months): 60.0
Total project cost (EUR): 1719600.0
EU funding (EUR): 1719600.0
Participants: 1
Project status: CLOSED

The study of primary immunodeficiency diseases has provided significant insights into how the immune system works. This notably includes in vivo immune responses to microorganisms, pathogens or opportunistic agents and in vivo control of reactivity to self, in relation to the identification of specific gene mutations. Hence, some of the key factors of the immune system have been unraveled. In this respect, studies in human conditions are essential because (i) they provide truly natural models of the immune system at work and (ii) because there are many known differences between the human and murine immune systems. Detailed investigations of newly described phenotypes and further delineation of known phenotypes which lack associated gene mutations represent as many new models for studying multiple facets of the human immune system. Appropriate in vitro and in vivo experimental models will be designed in order to gain a detailed understanding of newly identified molecules. It is also expected that the elucidation of immune system pathways will have an impact on therapeutic research. This proposal has been generated by a group of scientists with expertise in both fundamental and clinical research and aims at tackling some of these multifaceted questions. These studies will benefit from the well-characterized cohorts of patients with specific primary immunodeficiencies (PIDs) that have been constituted over the years. The project has 3 major subheadings: 1) Primary immunodeficiencies (PIDs) of DNA repair pathways, 2) PIDs of lymphocyte cytotoxicity/cell death pathways; 3) Therapeutics for primary immunodeficiencies. Scientists who take part in the project will address these various topics as a function of their respective fields of expertise. Also, as observed in the past, the unexpected observation of new phenotypes might significantly impact on research orientations, as a function of their potential interest and feasibility of their analysis.

Keywords: primary immunodeficiencies,dna repair,immunoglobulin class switch recombination,lymphocyte cytotoxicity,lymphocyte apoptosis lymphoid progenitors
Functions and mechanism of active DNA demethylation (DNADEMETHYLASE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: Germany,Germany
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2015-05-31
Duration (months): 60.0
Total project cost (EUR): 2376000.0
EU funding (EUR): 2376000.0
Participants: 2
Project status: CLOSED

Epigenetic gene regulation is of central importance for development and disease. Despite dramatic progress in epigenetics during the past decade, DNA demethylation remains one of the last big frontiers and very little is known about it. DNA demethylation is a widespread phenomenon and occurs in plants as well as in animals, during development, in the adult, and during somatic cell reprogramming of pluripotency genes. The molecular identity of the DNA demethylase in animal cells remained unresolved and has hampered progress in the field for decades. In 2007 we published that Growth Arrest and DNA Damage 45 a (Gadd45a) is a key player in active DNA demethylation, which opened new avenues in the study of this elusive process. The goal of this project is to further analyze the mechanism of DNA demethylation as well as the role played by Gadd45 in development. Given the many unresolved questions in this burgeoning field, our work promises to be ground-breaking and therefore have a profound impact in unraveling one of the least understood processes of gene regulation. Specifically we will address the following points. I) The biological role of Gadd45 mediated DNA demethylation in mouse embryos and adults is unknown. We have obtained mouse mutants for Gadd45a,b, and g and we will analyze them for developmental defects and dissect the methylation regulation of relevant genes. II) The targeting mechanism by which Gadd45 is binding to and demethylating specific sites in the genome is a central unresolved issue. We have identified a candidate DNA binding protein interacting with Gadd45 and we will analyze its role in site specific targeting of DNA demethylation in vitro and in mouse. III) We found that Gadd45 is an RNA binding protein and we will therefore analyze how non-coding RNAs are involved in targeting and/or activating Gadd45 during DNA demethylation.

Keywords: developmental gene regulation,dna methylation,developmental epigenetics
TERPENOYLATION: AN ORIGINAL CONCEPT FOR THE DISCOVERY OF NEW NANOMEDICINES (TERNANOMED)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: France,France,France,Belgium
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2015-05-31
Duration (months): 60.0
Total project cost (EUR): 2198799.0
EU funding (EUR): 2198799.0
Participants: 4
Project status: CLOSED

Terpenoids are a group of natural compounds that are extraordinary diverse in chemistry, structure and function. Most of the natural terpenoids are flexible and biocompatible biopolymers, having physico-chemical characteristics able to adapt to a wide variety of biologically active compounds. Surprisingly, they have never been used previously in the nanotechnology field for drug delivery and targeting purposes, except very recently by us to design squalene-based nanoassemblies. Thus, the current project aims to develop terpenoid-based nanoassemblies to improve the treatment of severe diseases incl. cancer, infectious and metabolic diseases. The conceptual approach is to chemically link a terpenoid to a biologically active drug molecule in order to allow the resulting bioconjugate to self-assemble as nanoparticles in water. Noteworthy, the nature of the polyterpenoid (ie. number of isoprenoid units) may be adapted to the hydrophilic/lipophilic character of the drug molecule to be transported, whereas the nature of the linkage (ester, amide, disulfide bonds etc.) will be selected according to the enzymatic content of the targeted diseased area. From the ratio between drug s and polyterpene s molecular weights, it is deduced that the drug loading will be dramatically improved as compared to the currently available nanomedicines. In other words, the pro-drug will form the nanomedicine by selfaggregation without the need of any other transporter material. The project will involve the following interdisciplinary aspects:(i) synthesis of drug/polyterpene bioconjugates,(ii)design of the nanoassemblies and their functionalization with recognition ligands,(iii)cell and tissue imaging and(iv)pharmacological evaluation in vitro (cell culture) and in vivo. Such ambitious and challenging project will be performed under Patrick Couvreur s leadership who has settled up a worldwide recognized multidisciplinary research team, unique in the nanomedicine world.

Keywords: terpenoids,squalene,nanoassemblies,targeted drug delivery,nanomedicine
Identification, isolation and characterization of novel pharmaceutically active cysteine-rich peptides from plants (PLANTPEPTIDOMICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-12-01
End date: 2013-11-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Natural products represent a pool of privileged structures that are optimized by evolution to interact with proteins and other biomolecules. The enormous structural diversity of natural products thus provides an indispensable resource in an effective search for new therapeutic agents. Plants are of particular interest as source of pharmaceutically active compounds since they are used to treat diseases and maintain health since prehistoric times. They produce an enormous variety of substances that play a role in the plant defense mechanisms against predation by microorganisms, insects, and herbivores. The classical phytochemical approach in drug discovery focuses on secondary metabolites such as glycosides, phenolics, carbohydrates, alkaloids and terpenoids. The therapeutic potential of plant peptides and proteins, on the other hand, is by far less well studied and has only recently gained broader interest. The main reason for this is that standard proteomic and metabolomic approaches are not suitable for a systematic peptide analysis. For that reason, we are aiming at developing a peptidomic workflow using ultra-high performance chromatography and state-of-the-art mass spectrometry to cover the mass range of interest for the detection of plant peptides. The focus of the proposed project is the identification, isolation and characterisation of novel pharmacologically active peptides and mini-proteins from different plant species. Of particular interest are small (less than 100 amino acid residues), cysteine-rich peptides and proteins (CRPs), and in particular cyclotides, that often show remarkable antimicrobial, antifungal, antiviral and insecticidal activity as well as other pharmacologically interesting effects.
The Initiation of Eukaryotic DNA Replication: Mechanism, Regulation and Role in Genome Stability (EUKDNAREP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-05-01
End date: 2015-04-30
Duration (months): 60.0
Total project cost (EUR): 2449998.99
EU funding (EUR): 2449998.99
Participants: 2
Project status: CLOSED

In each cell cycle, eukaryotic cells must faithfully replicate large genomes in a relatively short time. This is accomplished by initiating DNA replication from many replication origins distributed along chromosomes. Ensuring that each origin is efficiently activated once and only once per cell cycle is crucial for maintaining the integrity of the genome. Recent evidence indicates that defects in the regulation of origin firing may be important contributors to genome instability in cancer. Strict once per cell cycle DNA replication is achieved by a two-step mechanism. DNA replication origins are first licensed by loading an inactive DNA helicase (Mcm2-7) into pre-replicative complexes (pre-RCs). This can only occur during G1 phase. Initiation then occurs during S phase, triggered by cyclin dependent kinases (CDKs) and Dbf4-dependent kinase (DDK), which promote recruitment of proteins required for helicase activation and replisome assembly. Research proposed herein will lead to a deeper understanding of the mechanism and regulation of DNA replication. We have reconstituted the licensing reaction with purified proteins which will be used to characterise the mechanism of licensing and the mechanism by which licensing is regulated in the cell cycle. We will also use this system to reconstitute events leading to the initiation of DNA replication. We will use genetic and biochemical approaches to characterise the mechanisms by which perturbed licensing causes gross chromosome rearrangements. We will also explore mechanisms involved in regulating the temporal programme of origin firing and how origin firing is regulated in response to DNA damage. Work in budding yeast and mammalian cells will be pursued in parallel to exploit the specific advantages of each system.

Keywords: dna replication,cell cycle,yeast genetics
Gene networks controlling embryonic polarity, regulation and twinning (GEMELLI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2016-02-29
Duration (months): 69.0
Total project cost (EUR): 1997899.0
EU funding (EUR): 1997899.0
Participants: 1
Project status: CLOSED

Much of what we know about how embryos determine their axes of symmetry comes from research in invertebrates (mainly Drosophila) and cold-blooded vertebrates (mainly Xenopus). In both cases, polarity is set up by the localisation of maternal determinants in the cytoplasm of the fertilised egg. These determinants are inherited differentially by daughter cells, leading them to acquire different fates, which effectively fixes the axes of the embryo by the 8 cell stage. In contrast, in amniotes (reptiles, birds and mammals) embryonic polarity remains plastic until much later, just before gastrulation, when the embryo may contain as many as 50,000 cells. If an embryo at this stage is cut into fragments, each fragment can generate a complete embryo. This property, called &quot;embryonic regulation&quot;, is thought to be responsible for the generation of monozygotic (identical) and conjoined ( Siamese ) twins in humans and other amniotes. We know almost nothing about how polarity is determined in higher vertebrates or about the mechanisms of embryonic regulation and twinning. This project uses a multi-disciplinary systems approach to reveal the gene interaction network controlling polarity, regulation and twinning. The project will also generate a mathematical model of early development or &quot;virtual embryo&quot;, allowing prediction of experimental outcomes and clinical scenarios.

Keywords: gastrulation,conjoined twins,chicken,armadillo,human,primitive streak,networks