Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EU-wide internet banking application for managing more accounts from multiple banks in one place (EVERIFIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Slovakia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Everifin is an EU-wide internet banking application offering non-discriminative way to use banking services from multiple banks at the same time independent from citizenship in the EU member state. This is possible thanks to the new European regulation called PSD2. The regulation comes into full force in September 2019 and obliges all banks in the EU, Liechtenstein, Norway and Iceland to give licensed 3rd parties access to client data if the client asks for it. The licenses are issued by a local regulator and can be transferred to any member state. The challenge is that the customer data which banks provide, are all in different formats. Therefore, we have built a unique solution which brings all data into one standard. We can link all banks in the EU to Everifin and unify fragmented European market faster than anyone ever before. On top of the basic multi-banking functionality, we plan to deliver new disruptive financial services: eBills, instant payments and credit checks and, to name a few. We have already conducted a market research with real users and measured the size of the market opportunity of multi-banking and eBills. It is clear that these services are highly demanded and people are ready to pay for them. Our corporate partners are excited about the fully electronic invoicing solution - the eBills. They can significantly reduce the costs of printing and delivering invoices, while achieving 50% reduction of overdue payments. This means they spend less on sending reminders and because their customers receive eBills directly in the internet banking, the number of typing mistakes drops dramatically as well. In November 2019, Everifin received an investment from a Business Angel and took leaps forward in building the final product, ready to be launched at the end of 2019. Additional funding from SME instrument Phase 1 will help us to prepare the feasibility study and expand our business plan for the next features: instant payments and credit checks.

Keywords: psd2,einvoice,e bill,multi banking,instant payments,credit checks,credit scores
Cell mechanosensing in the extracellular matrix (CellMechSensE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2023-06-25
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Inside tissues, living cells can adhere to a heterogeneous fiber network, the extracellular matrix (ECM). Cells adjust their behavior in response to the local resistance they sense from pulling the neighboring fibers (mechanosensing). As they probe the network and respond to signals, cells can strongly distort the ECM and these deformations can serve as cues for other cells. The cell-generated forces can be large enough to trigger non-linear elastic effects and irreversible transformations of the ECM, resulting in drastic network remodeling. Yet, most theoretical studies have focused on small-force mechanical signals transmitted by an idealized static network. Therefore, the overall research aim of this proposal is to establish a theoretical framework to obtain fundamental understanding on how cells can exploit the non-linearities to extract accurate information by mechanically probing their surroundings. Recent advances in high-resolution, cell-scale imaging and measurement techniques now make it possible to calibrate quantitatively the model from experimental data and high computational power will permit a complete quantitative numerical study of the biological system. This project will bring understanding that will fill a crucial gap of knowledge on the mechanisms controlling individual and collective cell behavior, ultimately allowing key advances on our understanding of body functioning. This comprehension will have a major impact in guiding the design of biological implants and potentially avoid dramatic diseases. With this fellowship, I will extend my research area to biophysics and perform extensive computational simulations under the supervision of Prof. Broedersz. Conducting this research project will raise my academic profile as an expert in mechanical modeling of disordered networks. It will hence increase my chances to achieve my goal of becoming an independent research group leader in statistical modeling of disordered systems in France.

Keywords: mechanical heterogeneity,nonlinear deformations,plasticity,active network,mechanosensing
Topology in out of equilibrium strongly correlated systems (NonequilibriumAnyons)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-19
End date: 2024-03-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Topologically protected states of matter have sparked tremendous interest in the recent decades. They require new ways to classify quantum phases and bring abstract concepts defined in mathematics of topology to daylight in the form of integer or fractionally quantized response. Being based on nonlocal quantities, they are extremely robust and constitute promising candidates for the fault-tolerant quantum computation. Fractional quantum Hall (FQH) states –an intrinsically strongly correlated phenomena– prove to be even more exotic with the possibility of harboring nonabelian anyons. Although the initial studies on topology have focused on equilibrium properties, life is a dynamical system and our technology relies on non-equilibrium physics. Meanwhile following Feynman’s revolutionary idea of quantum simulations, ultracold quantum gases have been firmly established as clean and controllable platforms to investigate condensed matter models. Not only several topological systems like the Nobel-cited Haldane model have been observed for the first time in cold atoms, their success has extended beyond equilibrium. Even though the recent studies on out-of-equilibrium topological dynamics reveals new classification schemes and new connections between topological invariants, so far they remain restricted to single-particle physics. At this milestone highlighting the timeliness of this project, we will pioneer theoretical investigations into the uncharted territory of the out-of-equilibrium response of strongly correlated topological systems. Equipped with our expertise in non-equilibrium phenomena in single-particle topology, we will conduct analytical calculations supported by numerics to uncover the many-body analogues. This will include classification of out-of-equilibrium topological invariants and introduction of novel quench techniques into the study of FQH states, all the while bridging the gap with experiments by identifying system specific protocols to observe them.

Keywords: topologically protected states,optical lattices,fractional quantum hall effect,anyons,out of equilibrium,quantum quenches,integer quantum hall effect
Hybrid threats to Indonesia’s Maritime Security: an assessment of cyber and cyber-physical vulnerabilities in the world’s busiest shipping lanes (STRAITSECURITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

STRAITSECURITY investigates policy and legal challenges in the maritime sector posed by the rapid spread of technology and growing threats to cybersecurity. The project will focus on some of the world’s busiest commercial shipping lanes as case studies (the Straits of Singapore and Malacca, the Sunda Strait and the Lombok Strait – all of which are partially or wholly within the jurisdiction of the Republic of Indonesia). These shipping lanes are of vital importance to European trade to Asia and a blockage would affect all corners of the globe. The rise of autonomous vehicles, artificial intelligence, robotics and the internet of things raises a number of vulnerabilities and challenges to maritime security. The anonymous, borderless nature of cyberspace presents unique opportunities for hackers, terrorists and cybercriminals, as well as unprecedented challenges for policy makers and law enforcers. The burgeoning and ubiquitous reliance on technology, coupled with continued piratical and terrorist activity in the region, poses a severe security risk to shipping. In recent years, the concept of cyber-terrorism has gained widespread awareness. This multidisciplinary, original and innovative research aims to significantly advance our theoretical and empirical understanding of the intersections between physical and cyber threats to the maritime domain, by considering the real possibility of hybrid threats to maritime security, such as ‘cyber-piracy’ and ‘cyber-terrorism’. It also aims to address a number of conceptual problems that these raise and the respective implications in maritime security policy for the international community in general and the EU in particular. The research will deploy mixed qualitative and quantitative research methods and collect primary data by consulting with experts in law, policy, technology, maritime security and cyber security in the UK and SE Asia (Indonesia, Malaysia and Singapore) to inform its conclusions and recommendations.

Keywords: maritime security,cyber security,hybrid threats,southeast asia,indonesia,shipping,technology,piracy,terrorism
RAtional design of canceR ImmunoTherapY: one size does not fit all (RARITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 1499795.0
EU funding (EUR): 1499795.0
Participants: 1
Project status: SIGNED

Checkpoint blockade immunotherapies have revolutionized cancer treatment. However, this immunotherapy only benefits a minority of patients (< 15%), mainly those diagnosed with cancers having many mutations. Furthermore, checkpoint blockade therapy does not selectively activate cancer-reactive T cells. RARITY responds to these shortcomings, aiming to provide innovative solutions for the development of effective immunotherapies for patients who do not benefit from current treatments. The ground-breaking preliminary data included in this application demonstrates that cancer-reactive T cells can be naturally present in so-called non-immunogenic cancers and that they acquire distinctive phenotypes. RARITY will apply state-of-the-art technologies to fingerprint these phenotypes. This will allow the isolation of cancer-reactive T cells from tumour tissues and their employment as highly-effective therapies. Therapeutic vaccination with cancer antigens can also be used to induce T cell responses in patients where natural activation of cancer-specific T cells is not detectable. However, the applicability of vaccination is compromised by the lack of specific targets, particularly in malignancies with few mutations. RARITY will address this problem by deploying a novel class of cancer antigens. An unprecedented screening of non-exomic genomic regions will be done to detect unannotated proteins that arise from de novo transcription and translation events. These proteins can then be targeted by personalized immunotherapies. Finally, thought-provoking findings included in RARITY suggest that immune cell subsets other than T cells play a major role in anti-tumour immune responses. These subsets need to be fully inventoried and categorised so that complementary strategies to T cell immunotherapies can be developed. RARITY will do so by conducting multidimensional analysis of cancer microenvironments using imaging mass cytometry and ex vivo modulation of immune responses.

Keywords: cancer immunotherapy,whole genome,mass cytometry,neoantigens,neoantigen specific t cells,low mutation burden
Nose-to-Brain Delivery of Biopharmaceutics for the therapy of central nervous system diseases: A design-based approach for efficient drug delivery systems (Bio2Brain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Italy,Germany,Germany,Switzerland,Greece,Czechia,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3497297.76
EU funding (EUR): 3497297.76
Participants: 9
Project status: SIGNED

Bio2Brain aims to create a trans-European network of industrially oriented specialists fully trained and experienced, a significant driving force in innovating novel technologies to deliver biopharmaceuticals safely and via the nasal route of administration to the central nervous system (CNS). Diseases of the CNS and the spinal cord affect around 165 million Europeans with disorders such as Multiple Sclerosis, Alzheimer’s disease and Parkinson’s disease. CNS disorders are often connected with high morbidity, significant side effects, suffering of the patients and their families, as well as an enormous burden on the welfare systems. Therefore, in terms of social sustainability, Bio2Brain contributes to increased benefit for both, the society as whole and particularly for those individuals at a disadvantage through these disorders. A highly critical challenge of CNS diseases is the low central availability drugs in general and in particular of biopharmaceuticals like monoclonal antibodies (mAbs). Hence, approved medicinal products with a low CNS bioavailability are currently delivered via intrathecal, intracerebroventricular or intraparenchymal injections. In this way, they are delivered directly to the CNS. Unfortunately, such delivery systems are invasive, require a surgery with high risks, have a low patient compliance and are poorly controllable. Therefore, there is a critical need for a more safe and effective new approach, that means a paradigm shift, for drug delivery technologies in the treatment of CNS diseases. The Bio2Brain network will create a research environment for the interdisciplinary and intersectorial training of 13 ESRs supported by 11 academic teams (beneficiaries and partner universities), 6 key industrial stakeholders and an academic non-profit organization. As an important benefit, the close and frequent exposure of the ESRs to the private sector and to key technologies will significantly enhance their employability.

Keywords: drug delivery,formulation,particles,biomolecule,olfactory region,central nervous system,numerical simulation,intranasal,antibodies,gmp manufacturing
Role of extracellular miRNAs in T cell development, TH2 cell differentiation and TH2 cell-mediated effector function (miRNAs in TH2 cells)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 2
Project status: CLOSED

It is estimated that more than 200 million Europeans suffer from at least one type of allergy. This condition is elicited by an hyper-activated type-2 inflammatory response coordinated by T helper (TH)-2 cells. In spite a good insight into the molecular mechanisms that triggers TH2 cells activation, the lack in understanding their post-transcriptional regulation is hampering the access to new potential therapeutic targets to curtail the allergy epidemic. Micro-RNA (miRNAs) are regulatory molecules essential for life, which play a fundamental role in shaping cellular functions via post-transcriptional repression of the cellular transcriptome. Though previously considered to operate exclusively inside the parent cell, it is now acknowledged that miRNAs can exit cellular boundaries and control transcription in bystander cells. We recently reported that regulatory T (TREG) cells secret specific miRNAs to repress TH1 cell-mediated immunopathology, and ameliorate a mouse model of autoimmune disease. In this proposal, we will address the role of extracellular miRNAs for the normal T cell development and during allergic inflammation of the airways. To this end, we produced a novel animal model that allows - for the first time - to selectively ablate the activity of extracellular miRNAs in T cells. We will use biochemical, RNA-sequencing and bioinformatics analysis to identify the molecular mechanisms for miRNAs sorting to exocytosis and to identify the miRNAs transferred to and from TH2 cells. This proposal will significantly expand our understanding of transferred miRNAs in the contest of health and disease, and will uncover novel cellular pathways to exploit as therapeutic targets.

Keywords: extracellular mirnas,t cell development,allergy,helminth infection
History of European Urbanism in the 20th Century (UrbanHist)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Spain,Italy,Germany,Germany,Slovakia,Sweden,Sweden,Slovakia,France,Czechia,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-10-01
End date: 2021-07-31
Duration (months): 58.0
Total project cost (EUR): 3703651.56
EU funding (EUR): 3703651.56
Participants: 15
Project status: CLOSED

Throughout the 20th century, urban planning constituted itself as an important tool to spatially direct social developments. This applies to Europe more so than to any other continent. Urban planning contributed significantly to the emergence of the welfare state, strong economies and a relatively balanced settlement structure. However, urban planning also caused the suppression and destruction of some population groups, alongside natural and cultural resources. With the collapse of socialism in 1990, and the increasing importance of the EU, the 20th century ended with a multi-layered convergence in regard to the implementation of urban planning as a regulative and shaping instrument. Most studies on 20th century urban planning adopt a national perspective, while studies aiming to provide an overview focus on several core countries. Furthermore, methodological approaches are very heterogeneous. UrbanHist’s aim is to develop and sustainably promote a joint understanding of the history of urban planning in the 20th century from a European perspective. Complementing contributions of academic and non-academic partners will systematically increase the scientific level of the project. New knowledge, critical debates and dissemination will be strengthened. A reflective European identity will be promoted. UrbanHist intends to facilitate the breakthrough of the European planning history debate, which is currently in its initial phase of development. The four applying beneficiaries have different areas of expertise with regard to international planning history as well as international cooperation. They can look back on a long history of collaboration. The promotion of foreign doctoral students is part of daily university routine. In regard to the promotion and internationalisation of doctoral students, the four universities have already achieved a high standard.

Keywords: history of european urbanism,20th century,transdisciplinary approach
EEN Innovation Support Services for SMEs in North West Italy (ALPS INN3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 210558.75
EU funding (EUR): 210558.75
Participants: 10
Project status: CLOSED

The project, whose geographical coverage will be North-West Italy (3 regions : Piemonte Liguria and Valle d’Aosta) aims at roviiding and upgrading a specific framework service for supporting SMEs in the innovation management capacity . The service, delivered through provision of 96 individual companies’ service packages, will be directed to SMEs with international growth potential via product, process service and or business model innovation- with gaps regarding innovation management. In particular, the action will focus on the following specific objectives: 1. Fine tuning of a Key Account Management based customised service provision directed to: a. SMEs /Scale ups international growth, including participation to European programs b. SMEs Innovation capacity enhancement and innovation projects implementation, job creation and new market access c. SMEs Innovation results exploitation 4. Integration of the service within local business innovation support delivered, EEN specific service official embedding within the regional innovation ecosystem 5. Advisory skill enhancement: ALPS EEN personnel, assisting the experts in this Action, will increase expertise and competences, providing high level advisory on innovation management 6. Upgrading a EU shared support methodology for EEN staff, which could be adopted for profitably supporting other local SMEs 7. Contribution to the enhancement of a visible and well identified Coach/EEN experts community at EU level 8. Updating the operational internal manual/chart for a harmonized service within the EEN ALPS Consortium and contribution to definition of a common EEN operational manual

Keywords: smes,innovation mangement,business support services,enterprise europe network,high growth companies,start ups,business coaching