Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Efficient pathways to neutralization and radical production enabled by environment (ETMD_ICEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The relaxation of electronically excited systems like atoms and molecules embedded in environment is a key question in chemistry and photobiology and the underlying physical mechanisms have been widely studied. The applicant has predicted theoretically that there are two efficient electronic processes between a system and its neighbors even if the system itself is in its electronic ground state and does not have excess energy, making clear that an important gap exists in our current understanding of systems embedded in environment. There is extensive future potential in filling this gap and we aim at exploring and exploiting it in systems of physical, chemical, and biological interest. The discovered electron-transfer mediated decay (ETMD) [several variants of ETMD have been already verified experimentally] and intermolecular Coulombic electron capture (ICEC) mechanisms give rise to a plethora of surprising electronic phenomena relevant to many fields. In radiation damage, for instance, differently charged cations and electrons are produced by ionization and Auger processes, and ETMD and ICEC continue to be operative, neutralize cations and produce radicals in the environment also after the known mechanisms of radiation damage have ceased to operate. This leads to severe additional damage. Knowing the factors influencing the impact of ETMD and ICEC most, we can exploit this knowledge to be able to suppress or enhance this impact. Such a control is invaluable in many cases, may be even in radiation therapy. We are certain that the novel and fundamental ETMD and ICEC processes can be exploited to probe and control systems embedded in an environment. Such a breakthrough necessitates the advancement of current methodologies far beyond the state-of-the-art, and can only be achieved by the close collaboration of a highly motivated strong team of scientists over a long period of time. The support by the ERC will substantially contribute to the realization of this vision.

Keywords: efficient environment enabled electronic processes
AuTonomous intraLuminAl Surgery (ATLAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,Italy,Italy,Italy,Italy,Italy,Belgium,Belgium,Poland,Belgium,France,France,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-04-01
End date: 2023-03-31
Duration (months): 48.0
Total project cost (EUR): 3944508.84
EU funding (EUR): 3944508.84
Participants: 21
Project status: SIGNED

In modern surgery body lumens increasingly serve as access route to deeply located anatomic regions. Navigation through narrow and mostly fragile and deformable lumens requires considerable skill, dexterity and consequently imposes a large mental load. Visualization is notoriously poor. Due to phenomena such as slack, backlash and compliance the controllability of the instruments is bad. Surgeons undergo steep learning curves and even experienced surgeons often lack confidence about their gestures. Surgical risks including internal bleeding, tissue damage, puncture or rupture are imminent. ATLAS will produce a generation of European researchers that will develop robotic skills and techniques to automate complex surgical intraluminal therapies. Due to physiological phenomena or the surgical action the anatomy changes considerably, reducing the value of pre-operative data and imaging. Compliant instruments must be employed to navigate through lumens. As they proceed they deform and undergo complex and distributed contacts with the fragile environment. Step changes in intra-operative and distributed sensing, real-time modeling and 3D reconstruction, decision-making, intra-operative planning and autonomous control will be made to deal with the extreme variability that is encountered. Whereas assistive technology for steering flexible endoscopes, ureteroscopes, colonoscopes, guidewires and vascular catheters has been notoriously disparate and incoherent, ATLAS will develop and train researchers in identifying and exploiting the commonalities amongst these cases. This generalization will lead to a rigorous unified framework and guidelines to deploy assistive techniques tailored to each specific therapy. The ATLAS consortium consists of Europe’s leading institutes in the field of surgery automation and design and control of flexible instruments. It is backed up by a broad set of clinical and industrial partners that are eager to get involved in subsequent exploitation.

Keywords: autonomous navigation,minimal invasive surgery,continuum robotics,3d reconstruction,active catheters,novel actuation and sensing,vascular surgery,colonoscopy,ureteroscopy
COmmercializing first-in-class dCTPase Inhibitors for treatment of hematological Cancers (CODIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-01-01
End date: 2017-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 94738.0
Participants: 2
Project status: CLOSED

In our ERC grant GEnetic NEtworks as a tool for anti-CAncer Drug Development we used siRNA screening and genetic networks to identify dCTPase being involved in DNA repair and replication. Further studies revealed that dCTPase plays a role in the degradation of nucleoside analogues used in cancer treatment. We then used an RNAi approach to validate dCTPase as a target to improve nucleoside analogue therapy. The dCTPase protein was purified and we set up an enzymatic high-throughput assay to screen >65,000 compounds, which generated hits that inhibit dCTPase (IC50~1-10μM). Using in house medicinal chemistry we developed TH1217, a low nM potent and selective dCTPase inhibitor with favourable pharmacokinetic properties. TH1217 synergistically induces apoptosis and cell death in combination with cytidine analogue treatment in cancer cells in vitro and in vivo, but shows no increased toxicity in nontransformed dividing cells. Here, we want to explore the commercial potential of the dCTPase inhibitors identified in the ERC grant. In this programme, we will, with the company Oxcia AB, establish the viability of the business programme using technical analysis, develop a business strategy and direction, specifically secure IP, perform market analysis, develop a business plan, manage preclinical development and prepare for clinical trials in collaboration with clinicians and regulatory bodies, IMPD application to Medical Products Agency and identify and discuss with potential commercialization partners and funding agencies to support cost of clinical trials. We have a non-profit foundation that owns our IP rights in an effort to secure long term support for translational science aimed at bringing new therapies to patients. In our planned business model, we start a new company that holds an exclusive license to the IP from the foundation which is used to develop the overall business programme and attract investments.

Keywords: dctpase inhibitors,hematological cancers,new therapy,commercialisation,combination therapy,synergy,cytidine analogue
Magnetic Sounding of Mars (MarsMag)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Magnetic sounding is a powerful tool to explore the interior structure of a planetary body because electrical conductivity carries information on mineralogy, temperature and volatile content. We propose to apply this to Mars and thus shed light on important questions such as crustal water and therefore habitability of extraterrestrial bodies. Magnetic sounding relies on the principle that external fields induce currents in the subsurface. These induced responses provide information on subsurface electrical conductivity structure and can be measured from orbit and on the ground. While a range of techniques have mainly been developed for terrestrial investigations, this field of study has mostly been unexplored for other planets. Here, the magnetic field environment dictates the nature and geometry of the inducing external fields, and often times limited data sets pose new challenges. We plan to fully exploit martian data sets from orbit and on the ground to (1) characterize the magnetic field environment of Mars and (2) explore the electrical conductivity structure within the planet. This project will also pave the way for applying magnetic sounding methodologies to other terrestrial bodies, including Merurcy or the Moon. The deep interior of a planet or moon carries information on its formation and evolution and contributes to the goals of ongoing planetary missions such as the InSight mission to Mars. InSight, the first surface mission equipped with a magnetometer landed on Mars last fall and the host professor and the candidate are involved as Co-PI on the seismometer team and as science investigator on the magnetometer team, respectively. This Fellowship will therefore contribute and further consolidate ETH involvement with InSight. Finally, Martian seismic activity thus far seems to originate mainly in the crust and complementary investigations using magnetic sounding will improve our understanding of crust and mantle structure and its relations to marsquakes.

Keywords: mars,magnetic field,electrical conductivity
FUndamental studies and innovative appROaches of REsearch on magnetism (FURORE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Germany
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-01-01
End date: 2013-12-31
Duration (months): 60.0
Total project cost (EUR): 2049600.0
EU funding (EUR): 2049600.0
Participants: 1
Project status: CLOSED

Based on our developments of Spin-Polarized Scanning Tunnelling Microscopy (SP-STM) and Magnetic Exchange Force Microscopy (MExFM), both offering spin sensitivity and spatial resolution down to the ultimate limit of single atoms, we will study spin-dependent interactions between individual magnetic atoms on metal surfaces, in diluted magnetic semiconductors, on surfaces of magnetic insulators, as well as between single-atom tips and ultracold quantum gases. Besides the investigation of static spin states and spin interactions, we will manipulate spin states in a controlled manner down to the single atom limit by making use of the spin-transfer torque exerted by spin-currents from an atomically sharp SP-STM tip across a vacuum barrier. Moreover, we will combine spin-current induced magnetization switching experiments on magnetic metallic nanostructures based on SP-STM with pump-probe experiments, thereby studying the fundamentals of magnetization reversal processes both spatially and time-resolved. We will make use of the powerful combination of SP-STM with single-atom manipulation to probe spin-dependent interactions in artificial nanostructures. In the case of magnetic insulators we will probe spin states and spin-dependent interactions based on local measurements of the quantum-mechanical exchange and correlation forces between a single-atom tip with a well-defined spin state and single atoms of the sample. Spin excitations at the level of individual atoms will be probed by a combination of SP-STM with inelastic electron tunnelling spectroscopy, while the combination of MExFM with measurements of the damping of the cantilever oscillation will be employed to reveal local spin excitations in electrically insulating materials. Finally, we will couple an MExFM-type force sensor to the spin state of an optically trapped ultracold quantum gas with the challenging goal to combine scanning probe and quantum optical methods for manipulating quantum states of matter.

Keywords: scanning probe microscopy and spectroscopy,single spin physics
Patchy colloidal particles: a powerful arsenal for the fabrication of tomorrow new super-molecules . A theoretical and numerical study of their assembly processes. (PATCHYCOLLOIDS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Italy
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-04-01
End date: 2014-03-31
Duration (months): 60.0
Total project cost (EUR): 1559159.99
EU funding (EUR): 1559159.99
Participants: 1
Project status: CLOSED

An unprecedented development in particle synthesis is providing methods to generate high yield quantities of nano- and micro-particles of different shapes, compositions, patterns and functionalities and an unprecedented diverse spectrum of particle patchiness, significantly extending the naturally available choices. These methods draw from the diverse fields of chemistry, physics, biology, engineering and materials science, and, in combination, provide a powerful arsenal for the fabrication of new particulate building blocks, the molecules of tomorrow materials, self-assembling into molecular-mimetic and unique structures, fluids, and gels made possible solely by their design. The new particles offer the possibility to go beyond the spherical interaction case, to move from the colloidal atom to the colloidal molecule --- providing valence to colloids --- and to further strength the analogies between colloids and globular proteins. The present theoretical and computational project aims at providing new ideas for developing effective methodologies of bottom-up manufacturing, at providing the scientific community with the background necessary to fully control the self-assembly of these new building blocks as well as solutions to relevant condensed-matter physics problems. The project also aims at developing realistic models of DNA-functionalized nano and micro particles, presently the most promising and versatile building block of bio-colloid materials. Understanding the assembly of patchy particles will offer fine control over the three-dimensional organization of materials, as well as the combination of different materials over several length scales, making it possible to design a spectrum of crystal polymorphs and self-assembled ordered and disordered structures unprecedented in colloid science.

Keywords: patchy colloids,functionalized colloids,self assembly,patchy globular proteins,phase behavior,dynamic arrest,colloidal glasses and gels
Analytic Techniques for Geometric and Functional Inequalities (ANTEGEFI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Italy,Italy,Italy
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-01-01
End date: 2013-12-31
Duration (months): 60.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 3
Project status: CLOSED

Isoperimetric and Sobolev inequalities are the best known examples of geometric-functional inequalities. In recent years the PI and collaborators have obtained new and sharp quantitative versions of these and other important related inequalities. These results have been obtained by the combined use of classical symmetrization methods, new tools coming from mass transportation theory, deep geometric measure tools and ad hoc symmetrizations. The objective of this project is to further develop thes techniques in order to get: sharp quantitative versions of Faber-Krahn inequality, Gaussian isoperimetric inequality, Brunn-Minkowski inequality, Poincaré and Sobolev logarithm inequalities; sharp decay rates for the quantitative Sobolev inequalities and Polya-Szegö inequality.

Keywords: isoperimetric inequalities,sobolev inequalities,symmetrization,mass transportation
Scanning Nano-SQUID on a Tip (NANOSQUID)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Israel
Call:  (ERC-2008-AdG, 2008)
Start date: 2008-12-01
End date: 2013-11-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

At the boundaries of physics research it is constantly necessary to introduce new tools and methods to expand the horizons and address fundamental issues. In this proposal, we will develop and then apply radically new tools that will enable groundbreaking progress in the field of vortex matter in superconductors and will be of great importance to condensed matter physics and nanoscience. We propose a new scanning magnetic imaging method based on self-aligned fabrication of Josephson junctions with characteristic sizes of 10 nm and superconducting quantum interference devices (SQUID) with typical diameter of 100 nm on the end of a pulled quartz tip. Such nano-SQUID on a tip will provide high-sensitivity high-bandwidth mapping of static and dynamic magnetic fields on nanometer scale that is significantly beyond the state of the art. We will develop a new washboard frequency dynamic microscopy for imaging of site-dependent vortex velocities over a remarkable range of over six orders of magnitude in velocity that is expected to reveal the most interesting dynamic phenomena in vortex mater that could not be investigated so far. Our study will provide a novel bottom-up comprehension of microscopic vortex dynamics from single vortex up to numerous predicted dynamic phase transitions, including disorder-dependent depinning processes, plastic deformations, channel flow, metastabilities and memory effects, moving smectic, moving Bragg glass, and dynamic melting. We will also develop a hybrid technology that combines a single electron transistor with nano-SQUID which will provide an unprecedented simultaneous nanoscale imaging of magnetic and electric fields. Using these tools we will carry out innovative studies of additional nano-systems and exciting quantum phenomena, including quantum tunneling in molecular magnets, spin injection and magnetic domain wall dynamics, vortex charge, unconventional superconductivity, and coexistence of superconductivity and ferromagnetism.

Keywords: flux line lattice,vortex dynamics,dynamic phase transitions,molecular magnets,superconducting quantum interference device,scanning magnetic imaging
PoroElastic Road SUrface: an innovation to Avoid Damages to the Environment (PERSUADE)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Environmental technologies
Action type: Collaborative project
Countries involved: Belgium,Sweden,Denmark,Slovenia,Poland,Poland,France,France,Belgium,Denmark,Netherlands,Germany
Call:  (FP7-ENV-2008-1, 2008)
Start date: 2009-09-01
End date: 2015-08-31
Duration (months): 72.0
Total project cost (EUR): 4650637.3
EU funding (EUR): 3376692.3
Participants: 12
Project status: CLOSED

Low-noise road surfaces are recognized as a cost-effective tool for traffic noise abatement. The best performance can be achieved by optimizing surface texture and porosity. That way, a bottom line of a 3dB lifetime average reduction with respect to ordinary asphalt has been reached. Any progress must resort to another noise-relevant characteristic i.e. elasticity by which the noise due to tyre vibrations can be suppressed. A recently completed European project has shown that, in order to be effective, the elasticity of the road surface must be in the same range as that of the tyre itself. This explains why previous attempts of incorporating a little rubber in an asphalt mix failed to produce significant noise reductions. The solution consists of a fully rubberized, porous compound: a so-called “PoroElastic Road Surface” (PERS). Trials in Japan and Sweden have demonstrated vehicle noise reduction close to 10 dB. However, that promising technology is not ready for application. The following problems have to be solved: resistance to wear and tear, adhesion to the base, winter maintenance, mechanical behaviour and the following have to be clarified: rolling resistance, skid resistance, frost behaviour, fire hazard, workability and production/laying processes including workers safety. The project aims at developing a durable, cost-effective PERS using scrapped tyres, which would benefit the environment by contributing to abating traffic noise and vibrations but also helping to solve the problem of over 3 million tons of used tyres being dumped or burned every year in the 27 MS. One will take advantage of Swedish and Japanese experience. The former country is represented in the Consortium while the latter will be represented in an External Reference Group. Five countries including two NMS will host the experimental sites and test different variants of mixes and construction methods. One will also analyze the global, possibly positive impact on CO2 emissions.

Keywords: road,road surface,traffic,noise,vibration,tyre,waste,recycling