Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Infrastructure for NMR, EM and X-rays for translational research (iNEXT)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Israel,Germany,Germany,Spain,Finland,Greece,Hungary,Sweden,France,France,France,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,Denmark,Portugal
Call: Integrating and opening existing national and regional research infrastructures of European interest (H2020-INFRAIA-2014-2015, 2014)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 9999534.25
EU funding (EUR): 9999534.25
Participants: 29
Project status: CLOSED

Structural biology provides insight into the molecular architecture of cells up to atomic resolution, revealing the biological mechanisms that are fundamental to life. It is thus key to many innovations in chemistry, biotechnology and medicine such as engineered enzymes, new potent drugs, innovative vaccines and novel biomaterials. iNEXT (infrastructure for NMR, EM and X-rays for Translational research) will provide high-end structural biology instrumentation and expertise, facilitating expert and non-expert European users to translate their fundamental research into biomedical and biotechnological applications. iNEXT brings together leading European structural biology facilities under one interdisciplinary organizational umbrella and includes synchrotron sites for X-rays, NMR centers with ultra-high field instruments, and, for the first time, advanced electron microscopy and light imaging facilities. Together with key partners in biological and biomedical institutions, partners focusing on training and dissemination activities, and ESFRI projects (Instruct, Euro-BioImaging, EU-OPENSCREEN and future neutron-provider ESS), iNEXT forms an inclusive European network of world class. iNEXT joint research projects (fragment screening for drug development, membrane protein structure, and multimodal cellular imaging) and networking, training and transnational access activities will be important for SMEs, established industries and academics alike. In particular, iNEXT will provide novel access modes to attract new and non-expert users, which are often hindered from engaging in structural biology projects through lack of instrumentation and expertise: a Structural Audit procedure, whereby a sample is assessed for its suitability for structural studies; Enhanced Project Support, allowing users to get expert help in an iNEXT facility; and High-End Data Collection, enabling experienced users to take full benefit of the iNEXT state-of-the-art equipment.

Keywords: structural biology,protein crystallography,translational research,drug discovery,biotechnology
Structure-function studies of the general transcription factor IIIC (TFIIIC) (TF3C_EM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Transfer RNAs (tRNAs) act as adaptor molecules, decoding messenger RNA and delivering the correct amino acid to the growing peptide chain. Being instrumental in the cellular translation machinery, it is important to understand their synthesis mechanism. In eukaryotes, tRNA gene (tDNA) transcription begins with transcription factor IIIC (TFIIIC) bound to 2 gene-internal promoter elements, A- and B-box. This is followed by the recruitment of transcription factor IIIB and RNA polymerase III to form the transcription pre-initiation complex. In ‘TF3C_EM’, I will focus on the mechanism and molecular architecture of the very first step, i.e., TFIIIC binding to tDNA. TFIIIC is composed of two subcomplexes, τA and τB, that bind respectively to the A- and B-box, and are flexibly linked to accommodate varying lengths between their binding sites. Interestingly, TFIIIC has recently been termed as ‘guardian of the genome’ in light of its extra transcriptional roles, such as chromatin remodelling. This further highlights the importance of exploring its underlying structure. Using recombinantly purified TFIIIC, I will characterise the fully assembled TFIIIC complex and TFIIIC-tDNA interactions in vitro. To this end, an inter-disciplinary approach will be used, spanning complementing biophysical and structural techniques of single molecule FRET, cryo electron microscopy and X-ray crystallography. Thus, in my project ‘TF3C_EM’, I will tackle 3 major objectives: (1) characterisation of the molecular architecture of TFIIIC, (2) understanding the tDNA recognition mechanism by TFIIIC and (3) understanding the dynamics between τA and τB. It will unravel the structure-function correlation of TFIIIC and pave the way for further understanding the transcription initiation by Pol III. At the same time, it will allow me to pursue research in an unparalleled scientific environment and significantly contribute to shape my future career as an independent researcher.

Keywords: transcription,tfiiic,trna genes,cryo em
(P,C) and (O,O) well-defined gold(III) complexes for the development of new gold(III) catalytic processes (Gold3Cat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Over the last 20 years, gold catalysis has become a very efficient method for the rapid construction of complex and highly functionalized molecules. However, gold catalysis is mainly limited to the activation of π-systems by Au(I) complexes. Comparatively, Au(III) catalysis is poorly developed due to the rarity of stable but reactive Au(III) complexes. But recent studies showed that judicious ligand design enables to stabilize Au(III) complexes and that switching from Au(I) to Au(III) leads to completely different reactivity and selectivity. The Gold3Cat project envisions to elaborate a library of well-defined Au(III) complexes and to develop a new facet of gold catalysis thanks to the unique properties of these Au(III) complexes. The first step will consist in preparing a range of stable Au(III) complexes relevant to catalysis (WP1). P-Based chelate and pincer complexes are proposed, as well as (O,O) chelated complexes featuring a catechol moiety. The electronic properties of the new Au(III) complexes will be thoroughly studied to enable rational catalytic development and optimization. Given its importance but current limitations, efforts will concentrate on hydroarylation (WP2). This includes asymmetric versions in which the square-planar geometry of Au(III) should impart enhanced chiral induction (WP3). The ability of P-based pincer ligands to stabilize Au(III) carbene complexes will also be studied, and catalytic transformations taking advantage of the high electrophilicity of these unprecedented species are targeted (WP4). The Gold3Cat project is very ambitious both synthetically and conceptually, but it is built on solid foundations. It combines ligand design, advanced organometallic studies and important catalytic applications. Given the dynamism of the host group and the training plan involving broad scientific and personal development, it offers ideal conditions for the researcher to enhance its potential and prepare to start her independent career.
High density scalable optically interconnected Tb/s Board (Teraboard)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Spain,Italy,Italy,Italy,Italy,Belgium,France
Call: Photonics KET (H2020-ICT-2015, 2015)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 4249157.5
EU funding (EUR): 4249157.5
Participants: 10
Project status: CLOSED

Optical communications are becoming always more relevant because of the continuous growth of the requiested bandwidth. In the last decade we assisted a continuous growing of transport and metro netwotks, presently the bottleneck is in the processing of the huge amount of data constituted by the growing number of users, the capacity of the content that is exchanged and the convergence of Telecom and Datacom. This accumulation of data are elaborated and redirected within data centers with a continuous growing of traffic congestion. The continuous growth of traffic require therefore a roadmap of bandwidth density growth that necessarily has to be scalable on the timeframe of several years. To this point photonics plays a crucial role that is always more pervasive. However a major limiting factor is also arising from the energy cost and latency accumulated by the need of aggregation to route signals. To limitate this effect is necessary to make possible data exchange and processing without or with limited aggregation. Teraboard project consists in developing a full intra data center photonic platform for intraboard, intrarack and intra data center optical communications. The Teraboard interconnection platform will be based on ultra-high density and scalable bandwidth optical interconnectivity with low insertion loss and a target of lowest energy cost per channel of 2.5pJ/bit and a manufacturing cost of 0.1$/Gb/s in volumes. These target values are 10x reduction respect to commercial state of the art. Teraboard demonstrates: 1) passive, scalable, 3D inter processor interconnection layer, 2) novel WDM optical connector to plug the fiber ribbons directly onto the transceiver chip, 3) intraboard transceiver bank with high density bandwidth of 7Tb/s/cm2. Single wavelength laser arrays will be directly integrated on the silicon photonics transceiver circuits, 4) and edge single and four wavelength transceiver interface with bandwidth density of 50 and 7Tb/s/cm2 respectively.

Keywords: photonics integrated circuits,si photonics,2 5d integration,3d integration
Bis(alkyl-imidazolyl)propionate (BAIP) based bio-inspired mono-nuclear non-heme iron(II) complexes that catalyze challenging oxidative transformations of organic compounds (BAIPFeOTC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Here we propose the development of a new class of facial triad N,N,O ligands based on the bis(alkyl-imidazolyl)propionate (BAIP) architecture for the synthesis of bio-inspired mono-nuclear non-heme iron(II) complexes that have the ability to selective catalyze challenging oxidative transformations of organic compounds using oxidants like H2O2 or O2. Our specific aims will be: (i) To develop new sterically encumbered BAIP-ligands for the generation of highly reactive 1:1 Fe/ligand complexes, (ii) To develop ‘inverted amide’ versions of these ligands to generate Fe-amido complexes with low oxidation potentials for O2 activation, (iii) To study the reactivity towards oxidants (H2O2, O2) and the catalytic properties in challenging oxidation transformations (alkane hydroxylation, alkene cis-dihydroxylation) of the corresponding iron complexes. (iv) To carry out detailed mechanistic investigations on isolated and/or spectroscopically well-characterized iron complexes and intermediates that are involved in the reactivity of the new Fe-N,N,O complexes. The project will follow the so-called ‘synthetic analogue approach’, where small model compounds are developed to mimic the structural and functional features of metallo-enzyme active sites. In doing so, the model compounds may aid in the further understanding of metallo-enzyme reactivity and mechanism. At the same time the model compounds may be further developed into new synthetic catalysts. Carrying out this project within the Organic Chemistry and Catalysis (OCC) group at Utrecht University will place the candidate in the middle of the research activities of the Catalysis Centre Utrecht (CCU). This will allow the candidate to develop his knowledge and skills in the fields of bioinorganic chemistry and homogeneous catalysis, to further shape him for a future research career in the broader fields of molecular inorganic chemistry and molecular catalysis.

Keywords: iron,oxidation catalysis
Leveraging Pharmaceutical Sciences and Structural Biology Training to develop 21st Century Vaccines (PHA-ST-TRAIN-VAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-06-01
End date: 2020-05-31
Duration (months): 48.0
Total project cost (EUR): 1062698.4
EU funding (EUR): 1062698.4
Participants: 2
Project status: CLOSED

Immunisation is one of the most cost-effective and proven tools to control and eliminate infectious diseases, saving millions of lives each year, yet key challenges remain in order to guarantee the future health of the expanding and ageing global population. For example, effective vaccines are still required for Respiratory Syncytial Virus (RSV) and Group B Streptococcus (GBS), both of which cause significant hospitalisations globally each year. RSV is a common cause of respiratory disease among all age groups; annually it results in an estimated 33.8 million acute lower respiratory tract infections (resulting in 66,000-199,000 deaths) and among the elderly, it results in as many hospitalisations as influenza. Group B Streptococcus (GBS) infections also pose a serious risk; GBS is a leading cause of invasive infections in pregnant women, new-born infants, and the elderly. To meet the challenge of developing fit-for-purpose, age-appropriate vaccines against these disease targets, this EID will bring together two cross-sector, world leading teams – GSK Vaccines S.r.L and the University of Strathclyde – with the objective to equip the next generation of vaccinologists with the skills and tools to deliver vaccines for the 21st Century. GSK Vaccines S.r.L is a global leader in vaccine research, development and production and will work in partnership with the vaccine team within USTRATH and the Strathclyde Institute of Pharmacy and Biomedical Sciences, who have an international track-record of translatable and innovative research in immunology, immunomodulation, structural biology, and formulation design and pharmaceutical engineering of vaccine systems. PHA-ST-TRAIN-VAC will deliver a unique, multidisciplinary and intersectoral training programme to develop and equip four early stage researchers with the required skills and entrepreneurship to develop new vaccines to protect against RSV and GBS, in a formulation tailored to the age of the patient.

Keywords: vaccines,antigens,adjuvants,immunization,delivery systems
Novel clothing e-commerce application for reliable size assignment and realistic fitting visualization (VisuaLook)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

E-commerce has become a focal point of expansion and growth for the consumer goods industry. However, clothing market still accounts for a low ratio of online sales compared to more established sectors. Online apparel retailers have a 40% return rate, the highest in e-commerce, being bad fit the main barrier for the online market and causing 75% of these returns. In addition, final buying decision for fashion shoppers relies on the possibility to visualize realistically the look and fit of the garment and this is not possible with the current available technologies. The overall objective of TecnologíasDIM with this innovation project is to introduce in the clothing e-commerce market a disruptive web-based application (VisuaLook) for reliable size assignment and realistic fitting visualization integrating advanced ICT technologies: mobile application to capture the ‘personal avatar’ (3D body geometry and photorealistic visualization), web-based virtual try on software, and ICT architecture that supports the integration and communication. We expect to reach a leading position in the market, increasing rapidly the market share and sales of the company, encouraged by an innovative and competitive solution for our clients (clothing manufactures and e-retailers) and an easy and fast adoption of the end users (e-buyers), becoming a reference for clothing e-commerce. Firstly, we will conduct a feasibility study in Phase 1 in order to assess the integration of the core technologies, the shopping experience outline, the regulatory issues and the commercialisation strategy, ending with the elaboration of a comprehensive business plan. In Phase 2 we will perform a pilot study to demonstrate VisuaLook in a real environment with the collaboration of a relevant e-retailer of the clothing sector. VisuaLook will be ready for commercialization in Phase 3.

Keywords: clothing,e commerce,retailers,virtual try on,3d body scan,clothing fitting,clothing size
Enabling consumer action towards top energy-efficient products (TOPTEN ACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Austria,Germany,Spain,Italy,Norway,Belgium,Lithuania,Sweden,Romania,Poland,Switzerland,France,France,Czechia,Luxembourg,Portugal,United Kingdom
Call: Consumer engagement for sustainable energy (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-03-01
End date: 2018-08-31
Duration (months): 42.0
Total project cost (EUR): 1933671.5
EU funding (EUR): 1793866.5
Participants: 18
Project status: CLOSED

TOPTEN ACT aims at empowering consumers to ACT: to purchase top energy-efficient products that will save energy over their lifetime. TOPTEN ACT develops a comprehensive market transformation strategy targeting consumers, manufacturers, retailers, large buyers, consumer associations and other key actors in 16 European countries, covering a combined population of 447 Mio inhabitants. It works with these actors to help them embrace and promote energy-efficient products, so that they become the natural choice for consumers. Project partners will: - Manage 16 Topten websites presenting up-to-date, consumer-oriented information to 2 Mio visitors per year. These websites will showcase top energy-efficient models in a number of product groups: domestic appliances, cooling and lighting equipment, consumer electronics, vehicles etc. They build on independent and reliable market surveys selecting the best available technologies (BATs) amongst hundreds of thousands of products. → Consumers identify top products, compare costs and understand the benefits of energy performance on their electricity bills and for the environment. - ‘Push’ this information to consumers through extensive use of the media, communications and partnerships with key organisations acting as multipliers. → Impartial information reaches consumers. - Work with retailers, leveraging on their unique market position, directly in contact with consumers about to ACT, to further increase purchases of energy-efficient product. → In just one click, consumers will find and buy top efficient products. TOPTEN ACT impacts are both quantitative —savings of 331 GWh/year triggered per million € invested— and qualitative: markets are more transparent, media report on top efficient products, multipliers relay the Topten message to their target groups, consumers change their using and purchasing behaviour, retailers change their range and highlight BAT products, manufacturers shift their production lines.

Keywords: market transformation,consumer empowerment and education,retailers,energy labelling,ecodesign,green procurement,domestic appliances,consumer electronics,lighting,cooling
Design of a flexible, scalable, high quality production line for PEMFC manufacturing (INLINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Austria,Germany,Italy
Call: PEMFC system manufacturing technologies and quality assurance (H2020-JTI-FCH-2016-1, 2016)
Start date: 2017-02-01
End date: 2020-01-31
Duration (months): 36.0
Total project cost (EUR): 3286068.75
EU funding (EUR): 3286068.75
Participants: 5
Project status: CLOSED

The INLINE project aims at the solution of key challenges to enable the implementation of a scalable manufacturing process for fuel cell systems. Current manufacturing processes rely on manual work that has substantial limits in terms of cycle times, costs and scalability. Developments will start with the re-design and optimization of two key components: the media supply unit and the tank valve regulator. Both are components that are currently difficult to manufacture and are perceived as bottlenecks in the production process. Based on these new designs, an integrated production line will be planned using simulation tools. These tools will enable the evaluation of different layouts, part flow strategies and for different production scenarios. In terms of manufacturing tools, the end of line test will be improved to reduce cycle times by a factor of 3 and assistance systems for assembly stations will be developed that will enable scalability by reducing the need for training of workers. The overall target is to reduce the cycle time for production of a whole fuel cell system from 15 hours to less than 2.5 hours. Data gathering and analysis methods will be developed to enable the tracking of parts through the production line and - through a correlation of process and quality data - the continuous improvement of the production process. Demonstration of the end of line test and the assistance system will be done in hardware. The whole production line will be evaluated using a simulation tool that has been verified on the current production process. A set of engineering samples of the re-designed tank valve regulator and the media supply unit will be produced and used for tests of the integrated fuel cells and for assessment of the whole production process.A potential of 250 new jobs in manufacturing of fuel cells and for production of the key components will be generated by the project.

Keywords: fuel cell manufacturing,quality control,assembly