Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative nutrient recovery from secondary sources – Production of high-added value FERTIlisers from animal MANURE (FERTIMANURE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Innovation actions
Countries involved: Italy,Spain,Spain,Germany,Argentina,Spain,Italy,Belgium,Belgium,Belgium,Poland,Croatia,France,France,France,France,France,Netherlands,Netherlands,Chile
Call: Closing nutrient cycles (H2020-RUR-2019-1, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 8380523.72
EU funding (EUR): 7784512.25
Participants: 25
Project status: SIGNED

Total farm livestock population in Europe excrete around 1400 Mt of manure annually. More than 90% of manure produced is returned to agricultural fields. However, this is not being done in the most efficient and least leaky way. FERTIMANURE will develop, integrate, test and validate innovative Nutrient Management Strategies to efficiently recover mineral nutrients and other products with agronomic value from manure, to finally obtain reliable and safe fertilisers that can compete in the EU fertilizers market. FERTIMANURE focuses on “How to improve the agronomic use of recycled nutrients from livestock manure” to reconnect nutrient flows between plant and livestock production. Nutrient recycling relies not only in the technologies for producing bio-based fertilisers, but also in a better understanding and managing nutrients at the farm. The ambition of FERTIMANURE is to cover both technological approach for nutrient recovery and nutrient management. To this end, the technological approach will be covered by the implementation of 5 innovative & integrated nutrient recovery on-farm experimental pilots in the most relevant European countries in terms of livestock production (Spain, France, Germany, Belgium, The Netherlands), whereas the nutrient management will be addressed through 3 different strategies adapted to mixed and specialised farming systems: (Strategy #1) On-farm production and use of Bio-Based Fertilisers (BBF), (Strategy #2) On-farm BBF production and Centralised Tailor-Made Fertilisers (TMF) production and (Strategy #3) On-farm TMF production and use. A total of 31 marketable end-products (11 BBF & 20 TMF) will be obtained. The agronomic & environmental performance and their potential to replace conventional fertilisers will be assessed. Ultimately, FERTIMANURE seeks to provide an innovative circular economy model to favour rural development in agricultural sector by creating real synergies and links within farmers and other industrial activities.

Keywords: nutrient recovery,manure management,on farm pilot,novel technologies,bio based fertilisers,tailor made fertilisers
Understanding and targeting the functional consequences of aneuploidy in cancer (CancerAneuploidy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1612500.0
EU funding (EUR): 1612500.0
Participants: 1
Project status: SIGNED

Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a distinct feature of cancer. Recent years have seen conceptual, methodological and technical advances in the field of cancer aneuploidy research, but we are just beginning to scratch the surface of the underlying biology, and the potential vulnerabilities of aneuploid cancer cells remain under-explored. Cancer aneuploidy is therefore a biological enigma and a missed opportunity for cancer therapy. Identifying the “Achilles heels” of aneuploidy remains a holy grail of cancer research. However, current models of aneuploidy fail to fully recapitulate the cellular consequences of aneuploidy in cancer, thus compromising the identification of aneuploidy-induced cellular vulnerabilities. The time is ripe to tackle cancer aneuploidy with state-of-the-art genomic and functional approaches. In this project, I propose to address the following key questions: 1) What forces shape the evolution of aneuploidy in tumors? We will integrate in silico analyses of clinical data, in vitro modeling in isogenic human cell lines, and in vivo experiments in mice, to elucidate how various cellular contexts shape the tumor aneuploidy landscape. 2) What cellular vulnerabilities are induced by aneuploidy? We will combine isogenic cell lines with large-scale genetic and chemical perturbation screens, in order to identify, validate, and mechanistically dissect vulnerabilities induced by aneuploidy in human cancer cells. These research aims fall well within my unique expertise. I mapped various aneuploidy landscapes and developed innovative experimental and computational tools for studying cancer aneuploidy. A successful completion of the project will shed light on the context-dependent cellular consequences of aneuploidy in cancer and provide proof-of-concept for its potential targeting. Ultimately, identifying aneuploidy-specific vulnerabilities will pave the way for the therapeutic exploitation of this hallmark of cancer.

Keywords: cancer genetics,aneuploidy,chromosomal instability
Rethinking Urban Transportation through advanced tools and supply chain collaboration (U-TURN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Italy,Greece,Greece,Belgium,United Kingdom,Luxembourg,United Kingdom
Call: Reducing impacts and costs of freight and service trips in urban areas (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 2735542.5
EU funding (EUR): 2735542.5
Participants: 11
Project status: CLOSED

The U-TURN project aims at addressing freight urban distribution, focusing on food logistics. The project will contribute to our understanding of freight distribution in urban areas, especially addressing the special requirements and needs of food transportation, and will suggest innovative collaboration practices and tools towards achieving more efficient operations from both an environmental and cost perspective. The project will analyse existing freight urban flows, identify synergies and winning logistics sharing and collaboration strategies and will assess them in three ways: through comparative analysis based on actual market data, through simulation experimentation and via pilot execution in four different countries: Germany, UK, Italy and Greece. U-TURN will further contribute to the adoption of these strategies through managerial assessment, quantifiable benefits and the provision of tools, including a "smart" transport matching tool, a collaboration platform, a simulation tool and economic assessment model. The project aims to exploit the opportunities that currently exist for consolidation of transportation flows from food manufacturers to the various point-of-sales located in urban areas, as well as from local food producers and online retailers directly to consumers, and the high industrial interest behind this topic.

Keywords: supply chain collaboration,green food logistics,shared logistics,urban consolidation centers,logistics pooling,collaborative logistics
The Other Post-Criticism: Experimental Critical Writing by Women and the Future of the Literary Humanities (TOPCRIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 241398.72
EU funding (EUR): 241398.72
Participants: 1
Project status: SIGNED

The principal objective of The Other Post-Criticism (TOPCRIT) is to bring women’s innovative knowledge production in the field of contemporary literary criticism into a broader, more challenging definition of the novel concept of post-criticism. This ICT-enabled project uses a combination of interdisciplinary scholarship and innovative technologies to document, research and disseminate exciting forms of critical and interpretive production by women authors, building on the candidate’s proven track record in this original and distinctive line of research. The project’s interdisciplinary framework harnesses state-of-the-art theorisations of gender to challenge the current binding of post-criticism to a predominantly male philosophical legacy. Seeking to influence the paradigm of the post-critical at a decisive moment in its young history, and working at the cutting edge of debate on the function, forms and continued relevance of literary criticism, TOPCRIT provides the first account to date of women’s post-critical writing – including the use of generic experimentation, performance aesthetics, digital technologies, and a radical reimagining of the essay form –, situating these innovations alongside compelling theoretical discussions of post-criticism by women. TOPCRIT’s project design has at its core a strategy to ensure the maximum impact and visibility of the research, sharing outputs in formats and contexts designed to influence not only state-of-the-art academic debate and curricular models, but, through a vibrant outreach strategy, to spark wider public interest in the ways ‘literary’ texts and forms can perform key critical functions. Aligned with the objectives of the Horizon 2020 Sixth Societal Challenge (‘Europe in a Changing World: Inclusive, Innovative, and Reflective Societies’), the project is designed to document and highlight marginalised cultural production by women, strengthening women's key role in contemporary critical conversation.
DERMADROP - A COMPREHENSIVE TRANSDERMAL THERAPY CONCEPT FOR NON- HEALING WOUNDS AND OTHER SKIN DISORDERS (DERMADROP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Germany
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TDA is an unprecedented drug delivery technology developed and patented by Meddrop GmbH. This technology platform is capable of targeted delivery of active substances effectively and non-invasively. TDA transports a combination of both, oxygen and drugs through all skin layers. These results and that of a series of wound treatments on diabetic wound patients prove that TDA has a huge potential in many areas, including the healing process on deep and chronic non-healing wounds as therapeutic modality. Wound healing will be the primary target application of DERMADROP, a therapy concept based on TDA. DERMADROP’s secondary applications are related to skin diseases and disorders such as psoriasis, acne, stretch marks, inflammation and its tertiary application is in the aesthetic medicine. The objective is to comercialise DERMADROP as a multipurpose medical concept to be used in hospitals and clinics all around the world primarily as a therapeutic modality for non-healing wounds and for the secondary applications mentioned above. It offers a comprehensive therapeutic modality that covers all aspect of wound management and treatment from debridement to wound closure. Wound closure is also expected to be comparatively shorter than currently available modalities. Apart from the fact that current treatment modalities are time consuming and costly, the result is often not effective. DERMADROP is a comprehensive therapeutic approach for non-healing wounds with reasonable costs for healthcare providers and insurance bodies. It is affordable for patients and efficient in its results. Others medical advantages include comfort for patients and user-friendliness. The multi-functionality of DERMADROP would be an added value that complements it as a highly competitive therapy solution, marketed by Meddrop GmbH and its existing extensive international distribution network.

Keywords: wound care,chronic wounds,dermatology,psoriasis,neurodermatitis,diabetes,burns,pain management,developing countries,halal,kosher,de centralised health infrastructure
EQUIP-G - European QUantum Infrastructure Project for Gravimetry (EQUIP-G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Countries involved: France,Spain,Germany,Hungary,Portugal,Netherlands,Italy,Poland,Denmark,Finland,Belgium
Call: Developing and deploying a network of quantum gravimeters in Europe (HORIZON-CL4-2024-DIGITAL-EMERGING-02, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 24994403.29
EU funding (EUR): 24994402.5
Participants: 20
Project status: SIGNED

Imaging the Earth's interior has always been one of the key challenges in geosciences as it is a prerequisite for understanding our planet's internal dynamics and the coupling between its inner and outer envelopes. Gravity measurements at different altitudes (ground, airborne and space-based observations) provide a unique imaging tool, as they supply direct information on mass changes at different spatio-temporal scales. Following decades of research, developments and industrial transfers, quantum technology reached a high level of maturity and it is now possible to deliver operational quantum gravimeters offering various advantages with respect to devices that have been hitherto used. Aligned with the objective of strengthening EU’s strategic autonomy and competitiveness, EQUIP-G proposes to deploy a network of quantum gravimeters in Europe. This will represent the first step towards establishing the terrestrial segment of the pan-European quantum gravimetry infrastructure, revolving around a shared instrumentation facility (Instrumental Park). For this purpose, quantum gravimeters, dual quantum gravi-gradiometers and an onboard quantum gravimeter will be employed. These instruments will be comprehensively tested, before being deployed in the field. We will demonstrate, through innovative measurement strategies, the ability of the quantum gravity network to contribute to EU priorities, such as green deal, energy management and risk mitigation. Metrological oversight will ensure that all collected quantum gravity data will be SI traceable. Data will be managed in line with the FAIR principles and with a long-term perspective to establish a TCS for gravimetry within EPOS. EQUIP-G will engage in strong community building, aimed at involving the whole European gravimetry community in the development of the long-term Instrumental Park initiative that will extend beyond the end of the project, democratizing the use of quantum gravity devices produced in Europe.

Keywords: quantum field and airborne gravimeters network of quantum gravimeters european quantum instrumental shared park proof of concept of innovative measurement protocols and set ups
Protection of Cultural Heritage Against Wildfires in High-Risk Areas (FIRE-RESILIENCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 251578.56
EU funding (EUR): 251578.56
Participants: 2
Project status: SIGNED

The FIRE-RESILIENT project aims to create an interdisciplinary and innovative model to assess how well Immovable Cultural Heritage (ICH) can withstand wildfires in Wildland Urban Interface (WUI) areas. As cities expand and tourism increases, WUI zones—where urban development meets flammable vegetation—face rising wildfire risks. This project seeks to combine WUI and ICH analyses to improve wildfire risk management and mitigation. With climate change causing more frequent and severe wildfires, this research is timely and relevant, especially for regions like Northern Europe that are newly affected. Led by the Norwegian University of Science and Technology, in collaboration with the Universidade do Porto and the Fire Research and Innovation Centre, the project will develop an Emergency Preparedness and Safety Index (EPSI) to assess ICH. This index will consider protection systems and response capabilities. Using the Analytic Hierarchy Process to transform qualitative resilience data collected from interviews, EPSI will be integrated into a Geographic Information System that calculates risk based on available hazard maps from the European Forest Fire Information System and the developed index. This will allow for a comprehensive assessment of wildfire risk near WUI zones. The project will test the model on three ICH sites across Europe—the Trøndelag Folk Museum in Trondheim Norway, Alhambra in Granada Spain and the Dolmen of Antela in Oliveira de Frades in Portugal. These sites include both traditionally wildfire-prone areas and those newly impacted by climate change, such as Norway. By quantifying resilience data, this innovative method will offer powerful tools for evaluating and reducing wildfire risks to cultural heritage sites. The results will be freely available to local governments, cultural heritage managers, and researchers, providing a sustainable and advanced approach to managing wildfire risks, protecting cultural heritage, and adapting to climate change.

Keywords: geographic information system
Bridging protein structure prediction with molecular simulations via diffusion models for missing protonation states (PROTONIX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 2
Project status: SIGNED

Cancer and cardiovascular diseases are the leading causes of death in the EU, resulting in 54% of deaths in 2021. There is an urgent need for more effective therapeutics for these diseases, but drug discovery is slow, taking 16 to 20 years from target identification to drug approval. To accelerate drug discovery, pharmaceutical companies use computational tools. Among the most successful are physical molecular simulations, which are limited by the availability of experimental structural data. A new generation of machine learning (ML) powered structure prediction tools, such as AlphaFold, offer the potential to supply structural data suitable for physics-based modeling without the need to experimentally solve structures. However, these tools produce 3D structures missing key physical details, which are vital for accurate molecular modeling. A critical physical detail is the assignment of relevant protein protonation states, where misprediction results in large errors in drug binding affinity predictions, slowing down drug discovery. PROTONIX will bridge this gap between physical molecular simulations and ML structure prediction tools to improve the speed and accuracy of computational drug discovery, by adding protonation details to structure predictions. I will focus on the human kinase superfamily, the main therapeutic target class for cancer and cardiovascular diseases. PROTONIX will contain two open-source ML models. First, PROTONFOLD will use a diffusion model to predict relevant protonation states with their corresponding proton positions from ML protein structure predictions, generating simulation-ready files. Second, PROTONCON will use a flow-matching model to integrate protonation state prediction with multiconformer protein structure generation, providing insights into the coupling between protonation states and protein conformations. PROTONIX will point the way for future AlphaFold-like models to produce structures immediately useful for drug discovery.

Keywords: protonation state effects,kinases,protein structure prediction,computational drug design,generative modeling,diffusion models,protein conformer generation,constant ph molecular dynamics