Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Thresholds in past relative Humidity and Ecosystem Structure in Africa (THrESholds)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 176946.28
Participants: 1
Project status: SIGNED

Tropical forest and savanna are home to one-fifth of global human population. With ongoing global change, predicting how these biomes will respond to changing rainfall and relative humidity (RH) is of high priority. The overall aim of this project is to identify thresholds in RH that triggered in the past (last 10,000 years) the transition from forest to savanna and those that made forest resilience possible in Africa. I will use a new RH proxy, recently developed by the host laboratory, which is the triple oxygen isotope composition (17O-excess) of phytoliths. While calibrations were conducted in growth chambers, field applications are needed to precisely evaluate the accuracy of the proxy. I will examine the evolution of the 17O-excess in the water cycle and in grass and tree phytoliths, and quantify the isotopic fractionation at play, at a West African instrumented site. Then 17O-excess bias potentially brought by the contribution of phytoliths from lake shoreline vegetation to bulk sedimentary phytoliths will be quantified. Finally, I will analyse the 17O-excess of phytoliths from four West and Central African Holocene lacustrine sedimentary cores to reconstruct changes in RH. Vegetation structure and fire activity will be reconstructed from the same sediments. The effect of reconstructed RH and fire activity trends will be analyzed using time series cross-correlation and spectral analyses, and thresholds in RH identified using regime shifts analyses. These results will help to better understand the impacts of past climate change on tropical forest resilience. During this project, I will acquire new laboratory skills, develop the use of a new paleoclimate proxy, reinforce my scientific leadership and expand my career prospects in academia. I will bring my expertise in remote sensing analyses and biome management to the host laboratory. This project will also strengthen the European leadership in triple oxygen isotope analyses for paleoclimate reconstructions.

Keywords: relative humidity,triple oxygen isotope,phytoliths,forest,savanna,resilience,climate change
The Character of Monastic Landscapes in Early Medieval Europe (ChroMoLEME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The rural monasteries established across Europe in the 6th and 7th centuries played a key role in establishing the church’s centrality to medieval society. Scholars have traditionally accepted the medieval hagiographers’ descriptions of these sites as remote foundations in a wilderness known as the desertum. This interdisciplinary project will contrast these textual sources with an emerging body of archaeological evidence to question the traditional narrative. It will show that monasteries were intimately linked to political and economic networks and often founded in landscapes that were not only inhabited, but quite likely also Christianised. A case study of the 6th-century foundation at Annegray (France) will use an innovative GIS (Geographical Information System) environment to integrate conventional historical and archaeological data with innovative historic landscape character analysis using new remote sensing data. The resulting model will inform comparative study with comparable sites in France, Italy and Switzerland. The Fellow will receive advanced training in Geographic Information Systems (GIS), digital 3D survey and spatial data analysis. He will learn how to integrate conventional sources with remotely-sensed data from geophysical survey, airbone lidar (light detection and ranging), and terrestrial laser scanning (TLS) to create an innovative approach to Historic Landscape Characterisation (HLC). The method pioneered in the project will be broadly applicable to landscape studies of different periods and regions across Europe and beyond. During the project Dr Marron will develop extensive skills in a series of cutting-edge techniques, significantly enhancing his prospects of a successful career in interdisciplinary landscape research.

Keywords: early medieval,monasticism
European Dry Eye Network (EDEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Germany,Spain,Spain,Poland,Sweden,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EJD) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 2484775.44
EU funding (EUR): 2484775.44
Participants: 8
Project status: CLOSED

EDEN is a platform for the training and career development of 10 early-stage researchers (ESRs) in Vision Sciences. It coordinates research and training collaboration among 4 leading academic institutions in Europe, providing for a new combination of in-depth expertise from different countries. Furthermore, to strengthen the contact with the industrial world, the network has the following partners: 1 large company of hospitals, 1 SME that provides advance ophthalmic devices for ocular examination and 2 large companies specialized in eye-care products. It emphasises experience-based training through cross-disciplinary research projects that will analyse the lacrimal functional unit with state-of-the-art technology and assess the structural and physiological changes occurring in Dry Eye Disease (DED) patients. This will spur the generation of newer metrics to better differentiate between normal and DED patients. Further benefits include improvements in DED diagnosis and monitoring, studies on the effect of various DED treatments, development of DED aetiology-specific treatments and exploration of the risk factors that favour development of the disease or intensify its symptoms. EDEN will offer to 10 ESRs: (1) state-of-the-art approaches and techniques essential to studying DED through research projects, courses, and scientific exchange within and beyond the network; (2) essential career management skills via courses and practical activities aimed to develop their organisational, management and networking skills; (3) an understanding of the impact of research results for the private sector and insight into the business world via interaction with the industrial partners; (4) new possibilities of career development via professional contacts in academia and industry. The long-term synergies among EDEN partners, will structure European research and training capabilities in vision science. The training structure proposed will enable each ESR to earn a double PhD title.

Keywords: dry eye disease,ocular aging
Speleothems paleoclimate: accounting for isotopic disequilibrium (SPADE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2024-02-29
Duration (months): 78.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Understanding and quantifying the impacts of climate change at the regional and hemispheric scales are particularly difficult with respect to changes in rainfall and temperature patterns that lead to extended droughts and flooding events. Isotopic records in speleothems are increasingly used to determine climate variability on land and for data-model comparisons. However, transferring speleothem records into quantitative climate parameters suffers from a major limitation: speleothem formation processes result in geochemical disequilibrium and there is currently no way to correct for it in paleoclimate data. SPADE will shift the treatment of paleoclimate archives from regarding them as recorders of slow geological processes to consideration of geological material as recording much faster chemical reactions. As such, they cannot be assumed to form at equilibrium. SPADE will create a new framework, based on one classic and two novel isotopic tracers in carbonates (δ18O-Δ17O-Δ47) to quantify disequilibrium in cave records and overcome this underlying limitation. SPADE’s unique approach is based first on laboratory experiments that isolate chemical processes of speleothem formation, to test their respective effects on isotopic disequilibrium. Then speleothem analog experiments and modern cave material are combined to create speleothem specific calibrations for these isotopic proxies. These SPADE results will then be applied to classic paleoclimate records of dryland hydrology, such as Soreq Cave (Israel) and Devils Hole (Nevada). SPADE will address long standing climatic hypotheses regarding the interplay between temperature, amount of rainfall, surface evaporation, moisture sources, and regional climate connections in these drought vulnerable regions, and will make these records much more useful. A detailed understanding of disequilibrium will enable the use of these innovative geochemical tools in speleothems and more broadly, in other paleoclimate carbonate archives.

Keywords: clumped isotopes,speleothems
EU Training Network in understanding the molecular regulation and the role of endo-lysosomal processes in cardio-metabolic diseases (EndoConnect)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Spain,Finland,Switzerland,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2025-03-31
Duration (months): 51.0
Total project cost (EUR): 4050849.24
EU funding (EUR): 4050849.24
Participants: 13
Project status: SIGNED

The endo-lysosomal system is essential to acquire lipids and nutrients according to the need of the cell and, subsequently, to maintain metabolic homeostasis. The strong connection between the endo-lysosomal system and metabolism is reflected in the observations that defects in this system are correlated with cardio-metabolic disorders, such as cardiovascular disease, type 2 diabetes and non-alcoholic fatty liver disease. The molecular mechanisms that interconnect the endo-lysosomal system with metabolism are, however, poorly understood. This can be largely explained by the fact that (1) endo-lysosomal and metabolic research are carried out independent of each other and (2) the number of model systems to study endo-lysosomal processes at an organismal and clinical level are limited. It is the ambition of EndoConnect to change this by bringing top scientists and industrial partners together to train early stage researchers in interdisciplinary research, with the focus on translating key findings from cellular and animal models to patients with cardio-metabolic diseases. It is our mission to: (1) understand the molecular organization and regulation of endo-lysosomal processes, (2) elucidate how metabolism and endo-lysosomal processes are intertwined, (3) understand how defects in the endo-lysosomal system contribute to the development of cardio-metabolic diseases and, finally, (4) how the endo-lysosomal system contributes to the efficiency of therapeutics. EndoConnect will provide an international training program for early stage researchers to acquire knowledge and state-of-the-art scientific, technical, and transferable skills to connect molecular and cell biology research with physiology and biomedical research towards translation. We expect that EndoConnect will increase our understanding of the molecular interrelation of the endo-lysosomal system with cardio-metabolic diseases, which will pave the road for novel diagnostics and therapeutics.

Keywords: endosomes,lysosomes,intracellular transport,organelles,cholesterol,metabolism,cardiovascular disease,liver,adipose tissue
Screening for liver fibrosis - population-based study across European countries (LiverScreen)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Italy,Switzerland,Belgium,Switzerland,Croatia,France,France,Netherlands,United Kingdom,United Kingdom,Denmark
Call: Towards risk-based screening strategies for non-communicable diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 5996481.25
EU funding (EUR): 5996481.25
Participants: 23
Project status: SIGNED

Liver cirrhosis is a very common and severe chronic disease, responsible for high morbidity, impaired quality of life, major healthcare costs, and poor survival, causing an estimated 170,000 deaths per year in Europe. Liver cirrhosis is preceded by a long period of slowly developing, asymptomatic, liver fibrosis; most commonly caused by non-alcoholic fatty liver disease (NAFLD, related to obesity and type 2 diabetes), alcohol, and hepatitis B or C virus infection. There is no treatment available to reverse advanced liver cirrhosis. However, if fibrosis could be detected early, all of the major causes are still amenable to prevention and treatment. Early diagnosis of liver fibrosis in the general population is therefore crucial for the estimated 10 million Europeans with undetected liver fibrosis. The LiverScreen project aims to develop a targeted screening methodology to identify persons with asymptomatic liver fibrosis and cirrhosis among the general population. This methodology involves: 1) identification of groups from the general population at high risk of having chronic liver disease, 2) screening their liver stiffness with the innovative transient elastography (TE) technology (until now only validated in patients with known liver disease) for diagnosis, and 3) determining the right follow-up screening regime. Within the LiverScreen project 8 European countries will collaborate and perform research in over 34,000 subjects to develop the screening methodology and demonstrate its accuracy, clinical value, cost-effectiveness, acceptability, and potential to be implemented by healthcare systems throughout Europe. Using the LiverScreen program, diagnosis at an early stage can stop liver disease progression and have a subsequent long-term impact on liver disease morbidity and mortality and the associated societal burdens in terms of economic costs and health inequity. The estimated cost reduction ranges from €850 to €4,000 per quality-adjusted life-year gained.

Keywords: liver disease,cirrhosis,fibrosis,screening methodology,te technology,validation,risk factor stratification,cost effectiveness analysis,implementation strategy
Living with Vultures in the Sixth Extinction: An Ethnographic Study of Avian Conservation in Changing European Landscapes (LiVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-01
End date: 2024-08-26
Duration (months): 36.0
Total project cost (EUR): 321238.08
EU funding (EUR): 321238.08
Participants: 1
Project status: SIGNED

LiVE provides a historically informed comparative ethnography of contemporary vulture conservation in changing European landscapes. It investigates how the global phenomena of accelerating species loss and corresponding wildlife management unfold within specific historical and cultural contexts. Based within the discipline of social anthropology, and drawing on an interdisciplinary framework, the project expands science-centred discourses on wildlife conservation and management to include social and cultural analysis. It will do so through a timely in-depth qualitative analysis of the situated practices, techniques and ideas involved in vulture conservation today, emplaced in two rural communities in Andalusia, Spain, and the Massif Central in France. Using participatory methods the project involves close collaboration with conservation practitioners and stakeholders in the field. Through integrating the latest interdisciplinary knowledge from avian conservation science and vulture biology into social analysis, as well as by experimenting with more-than-human ethnographic methods, the project results in an innovative study of how to understand and manage wildlife conservation in the Sixth Extinction. Insights gained through the study will be of relevance to academic and applied environmental research, whilst also contributing new knowledge to wider cross-disciplinary public debates on the challenges and possibilities of human-wildlife coexistence in anthropogenic environments. In doing so, it applies RRI principles and contributes to addressing challenges of sustainable development specified in the Horizon 2020 Work Programme and the UN Sustainable Development Goals.

Keywords: environmental anthropology,environmental humanities,human animal relationships,conservation,environmental change,vultures
Non-canonical nucleoside incorporation into synthetic RNA-oligonucleotides: investigations towards the discovery of selective RNA-binding proteins (OLIGOBINPRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The increase of life expectancy around the world comes at the unavoidable cost of a rise in the occurrence of neurological diseases such as Parkinson’s as well as debilitating ones like cancer. These conditions prevent the possibility of a sustained quality of life and cost society vast amounts of money for the treatment and care of patients. It is the responsibility of scientists to find innovative methods of treating and eliminating these diseases, allowing for a healthier quality of life. Recently, RNA-binding proteins have been linked to biological processes leading to these diseases as well as the expression of genes relating to obesity. A plethora of natural chemical modifications in RNA fine-tune its structure, allowing for this specific interaction which regulates processes such as gene expression and the tuning of translation. Although these have been known for years, their binding proteins have not been systematically studied. The difficulty of the chemical synthesis of modified oligoribonucleotides represents the major bottleneck in this field. The overall aim of this project is to discover RNA-binding proteins which bind to the non-canonical modifications Am, Cm, Gm, i6A and ms2i6A which were identified in the mRNA of human cancer cell lines. These will first be synthesised and then incorporated into oligoribonucleotide strands mimicking natural mRNA. By incubating with cellular extracts, we subsequently aim to identify their binding proteins by tagging them with novel technologies and analysing them using mass spectrometric techniques. This project will inspire and offer unique training to Dr. Michaelides by exposing him to this multidisciplinary field where chemistry and biology meet, enabling him to embark on his own academic career. Furthermore, it will set the foundation for the better understanding of the mechanisms responsible for the aforementioned conditions, which will in the long term lead to the design of new therapies for their prevention.

Keywords: non canonical nucleosides,oligonucleotides,rna binding proteins,bioorthogonal chemistry
EPIGEN: A New Predictive Response Test for Non Small Cells Lung Cancer Treatment (EPIGEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2015-10-31
Duration (months): 2.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

EPIGEN test is a ready-to-use tool capable to lead the oncologist to the best Non Smal Cell Lung Cancer treatment, the most common subtype of lung cancer (80% of cases). The standar treatments to combat NSCLC are both chemo- and radiotherapy, but many patients (up to 65%) presents resistance, and currently there is not any tool available for the clinician to predict it. The EPIGEN test will allow the clinician a patient stratification in terms of the patient susceptibility to radio- and chemotherapy, and therefore lead for a personalyzed prescription. The EPIGEN test tecnology is based on the determination of the methylation percentage of the epigenetic biomarker IGFBP-3 in the patient tumor samples. The methylation percentage of IGFBP-3 is determined by using qMS-PCR (quantitative methylation specific polymerase chain) tecnique, a well known and extended biochemistry tecnique. The methylation percentage provided by using the EPIGEN test protocol and reagents in the qMS-PCR tecnique will lead the clinician for the optimal NSCLC treatment, avoiding the possible patient resistance to chemo and radiotharapy, and therefore unnecesary side effects and costly therapies.

Keywords: biomarkers,epigenetics,nsclc,lung cancer,chemotherapy,radiotherapy