Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Real-time imaging and classification system for low-grade glioma detection during brain surgery (IntraopRealtimeTumor)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Brain tumors remain one of the most incurable illnesses we know; patients have poor prognosis and less than a decade of life expectancy. The oncologist’s toolkit is rather limited as chemotherapy agents have limited access to the brain due to the blood brain barrier selective permeability and radiotherapy results in extensive damage to tissue well beyond the targeted area; leaving surgical removal of the tumor as the most effective approach. It has now become clear that the completeness of the surgical removal of the tumor is the most important factor determining recurrency of the illness. As such, tools that enable neurosurgeons to effectively remove the tumor are of fundamental importance in the surgical theater. Recent advances in intraoperative fluorescent labeling of common brain tumors has proven to dramatically improve surgical outcome. Unfortunately, no such labeling or intraoperative aid exists for the highly infiltrative low-grade glioma (LGG), making it the deadliest type. This PoC project aims to tackle this urgent unmet need and develop an intraoperative, real-time imaging and tissue classification tool for precise on-site identification of LGG tissue. The core technology emanates from the multiphoton ultrafast volumetric imaging we developed (now able to run in real-time) to study the link between neuronal activity and blood flow. Here we harness this unique technology and extended it to perform real-time label-free multimodal acquisition and image processing using the latest deep-learning tools. Our tool will provide surgeons with the ability to discern, while operating, healthy vs tumor tissue. Together with neurosurgeons, a technological hardware partner and an expert in artificial intelligence, we are positioned to generate the first-of-its kind prototype and to seek its commercialization. Such a tool is expected to become a game changer in brain and other tumor surgeries, improving the life expectancy and quality of many patients and families.
Structural biology tools for Antibiotic Research (STAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-11-01
End date: 2027-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Antimicrobial resistance (AMR) is escalating due to multidrug-resistant (MDR) bacteria and a dwindling antibiotic pipeline and is projected to cause up to 10 million deaths annually by 2050. Lipid-targeting (LT) antibiotics such as daptomycin and polymyxins combat MDR infections by disrupting bacterial membranes, yet their mechanisms remain unclear due to major technical challenges for structural biology. This knowledge gap hinders the development of next-generation LT-antibiotics with improved efficacy and safety profiles. STAR will positively impact structural biology capabilities by channeling the potential of Solid-State Nuclear Magnetic Resonance (ssNMR) spectroscopy to provide atomic-level insights into LT-antibiotic interactions under physiologically relevant conditions. By optimizing the scaled production of pure, 13C/15N-labeled phospholipids, STAR will overcome key technical hurdles that have constrained ssNMR’s application in antibiotic research, dramatically boosting ssNMR sensitivity and enabling selective detection of specific lipid interactions in complex membranes. This breakthrough will allow high-resolution visualization of drug-lipid interactions of antibiotics, enabling a transformative platform to elucidate the mechanism of action (MoA) of LT-antibiotics and guide the development of potent new derivatives. To bridge a critical knowledge gap in antibiotic research, STAR will optimize the scalable bacterial production of 13C/15N-labeled phospholipids for higher yields and refine purification techniques to enhance ssNMR signal sensitivity at larger scales. Additionally, STAR will evaluate commercial feasibility and intellectual property strategies to facilitate ssNMR’s market entry. By enabling deeper molecular insights into LT-antibiotics, STAR will accelerate antibiotic research and discovery, addressing the urgent threat of AMR.
Commercialization of a novel long-duration all-iron redox flow battery system for efficient, cost-effective (<66% less), sustainable, and scalable green energy storage (R.Flo LDES)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ukraine
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2450000.0
EU funding (EUR): 2450000.0
Participants: 1
Project status: SIGNED

R.Flo, founded in early 2023, offers a novel long-duration all-iron redox flow battery system for efficient, cost-effective (<66% less), sustainable, and scalable green energy storage.The renewable energy sector faces numerous challenges including corporate influence, government rules, political pressure, outdated infrastructure, inadequate battery storage systems, and current market conditions.In 2021, the EU27's stationary battery market more than doubled, with 2.2 GW/3.7 GWh of installations annually. At the end of 2022, the total installed capacity which mainly consisted of Li-ion batteries was at 4.6 GW/7.7 GWh. The EU accounted for only 14% of the installed capacity worldwide. The EU's robust grid and market-oriented storage deployment strategy are responsible for this comparatively low percentage. To achieve the goals of the REPowerEU Plan and support the European Green Deal, especially to lessen the dependency on gas-fired peaking plants, more acceleration is required. Regarding the marketing side, the cost of these batteries is still relatively high and enhancement of performance of the batteries is still needed. The primary issue is the lack of reliable, cost-effective, and long-lasting energy storage systems that can store renewable energy and provide baseload power, especially during periods of low generation from intermittent sources like solar & wind. With our groundbreaking value proposition, we addresses the critical pain points of renewable energy developers, industrial consumers, grid operators, and energy traders, by providing a reliable, cost-effective, and environmentally friendly alternative to existing technologies. We target the global energy storage systems market, currently valued €247.8B. Our serviceable available market is the electrochemical energy storage market, currently valued at €7.4B (14.2% CAGR), which we enter a first mover. As we provide a cornerstone solution for the respective equipment, we can participate in this growth.

Keywords: energy,storage,renewables,electrochemistry,batteries,fuel cells,electrical engineering,electronic engineering,solar,wind,grid stability,power,flow battery,green energy,long duration
Science in the City, Malta (Science in the City)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Malta,Ireland
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 255142.86
EU funding (EUR): 250000.0
Participants: 4
Project status: CLOSED

The European Researchers’ Night, Science in the City Consortium, Malta, will engage the publics in the framework of a Science and Arts festival. In 2022, the festival theme ‘Taking Root’ builds upon previous themes while focusing the festival on the European Green Deal and Horizon Europe's missions. Taking Root emphasises how important science and research are in everyday life, and in active, responsible citizenship, in a world which is undergoing monumental changes, especially to its environment, nutrition and health. COVID-19 has shown us just how true this is, while climate change is an unavoidable threat we need to adapt and build resilience towards. The festival will be held online and in the streets and buildings of Malta's capital city, Valletta, a UNESCO world heritage site making it the second hybrid science and arts festival. The main aims of ‘Science in the City’ (SitC) since 2012, have been to engage people emotionally and intellectually through science and the arts, showcase local and international excellent research projects, increase awareness of the importance of R&I, encourage interest in STEM and research carers, and instil a more favourable attitude towards research and its public funding. It has done so by introducing creativity, critique and analysis, as well as the trend of Responsible Research and Innovation (RRI) among researchers and citizens alike. For ten years it has offered a platform for all stakeholders to meet, discuss and engage with R&I. In 2022, the element of research action design will be at the centre of the activities. Here collaborative, creative planning and design of activities grounded in the vision and needs of the community will bring all stakeholders on board from the start. Every stage of SitC will be developed using a user-centered and participatory design process to make the festival as inclusive as possible no matter their background.

Keywords: research,researchers,stem,pupils,volunteers,careers,festival,science,arts,engagement,quintuple helix,responsible citizens,active,
Greek in the West: language communities, migration and the transformation of society in western Europe, 300–700 CE (GREEKWEST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1440137.0
EU funding (EUR): 1440137.0
Participants: 1
Project status: SIGNED

This project reconstructs the place of Greek in the sociolinguistic landscape of western Europe during Late Antiquity (300–700 CE). Integrating textual and epigraphic evidence, it will trace the evolving use and knowledge of Greek in literary and political culture, religion, and daily life. This period witnessed transformations that would change the shape of European history: the rise of Christianity, the fragmentation of the western Roman empire, the introduction of new political and economic institutions, and the resulting restructuring of civic society. Views on the place of Greek in the late antique West still centre around deterministic narratives of ‘decline and fall’, leading to instances of Greek knowledge being dismissed as outliers, thus missing opportunities to examine the period’s continuing cultural, political, and linguistic interactions between ‘East’ and ‘West’. Challenging this consensus, GREEKWEST is ground-breaking in that it is the first study to examine Greek’s changing role in the late antique West and to do so across multiple social contexts. Spoken by roughly half the empire’s inhabitants, Greek had long occupied a central role in Roman society. On the one hand, Greek was seen as a language of high culture and prestige, and educated elite Romans were expected to be bilingual in Latin and Greek. At the same time, Greek was often associated with people from less privileged parts of society: slaves, performers, and merchants. This project seeks a) to establish who knew and used Greek in the late antique West and what sectors of society they came from, b) to reconstruct the motivations for using and learning Greek, and c) to trace how individuals and communities in the West learned and accessed Greek knowledge. This research will fundamentally change our understanding of the social history of language and migration, late antique intellectual and political culture, and the paradigms by which we view the transformations of the Roman world.

Keywords: late antiquity epigraphy bilingualism and sociolinguistics
Ultrafast Laser Assembly of Metasurfaces with Large Scale Fabrication Capabilities (METASCALE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

Modern nanophotonic devices are redefining what can be achieved in terms of manipulating light, as they provide a versatile design platform for moulding the propagation of light at will. In particular, free-space and integrated optical metasurfaces (MS) are currently offering a promising route towards the realisation of compact and lightweight optical components for sophisticated engineering of the amplitude, phase and polarisation of electromagnetic waves, which could ultimately replace current conventional bulky optics in a near future. Yet, today the realisation of MS is based on the combination of precise, but time-consuming and energy inefficient nanofabrication techniques that rely on expensive and highly specialised equipment operated in strict cleanroom environments: conditions which are beyond the capability of a vast majority of industrial entities. The main objective of METASCALE is to develop alternative fabrication techniques based on ultrafast laser processing (ULP) strategies, towards the realisation of MS operating in the visible and infrared spectrum. Such processes will be compatible with large-scale, cost-effective and green manufacturing routines, thus appropriate for current industrial environments. For this purpose, METASCALE will specifically focus on the physical fabrication and testing of pre-designed metasurfaces, based on ultrafast laser assembly techniques such as direct laser writing, or laser interference patterning. Such ULP techniques are highly versatile and repeatable in terms of surface micro- and nano-patterning, but at the same time require a deep understanding and careful adjustment of a broad range of linear and non-linear laser-matter interaction mechanisms and their related timescales. METASCALE is therefore an interdisciplinary and collaborative effort involving many scientific branches ranging from material science to ultrafast optics or computational physics.

Keywords: microfabrication,nanofabrication,mass production
Breaking the Resolution Limit in Two-Photon Microscopy Using Negative Photochromism (4for2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,Spain,Belgium
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 2266125.0
EU funding (EUR): 2266125.0
Participants: 4
Project status: SIGNED

Multiphoton microscopy is a benchmark tool in biomedical research, used for the fluorescence imaging in cellular environments. This has important implications for disease diagnosis and the monitoring of therapy response. In conventional two-photon microscopy the fluorescence intensity of the employed molecular probe is proportional to the square of the excitation light intensity, implying that the fluorescence from the sample is confined around the focal point, yielding good spatial resolution. The spatial resolution can be dramatically improved by drawing on higher-order processes such as four-photon absorption. However, its practical implementation imposes major technical challenges, such as extreme laser intensities in the deep NIR. For this reason four-photon microscopy has so far attracted academic interest only. The present proposal addresses this issue and provides a multidisciplinary answer to the question: Can we develop a technique that offers spatial resolution of four-photon microscopy, but relies on two-photon absorption? This would combine the upsides of two-photon microscopy (low excitation energies provided by standard lasers at around 800 nm, high penetration depth in tissue) with the superior spatial resolution of four-photon microscopy. The result would be nothing less than a true paradigm shift in multiphoton microscopy. The key to tackle this highly ambitious task lies in the design of molecules that combine two mechanistically entangled two-photon processes (4for2) for the generation of a fluorescence output. This is possible by merging two-photon absorption, two-photon FRET-induced photoisomerization, and negative photochromism. Purposefully designed switchable fluorophores, that unify these photophysical assets, will be developed and their performance will be critically validated in a multi-angle spectroscopic work-flow, including the demonstration in application-relevant biological environments.

Keywords: photochromism molecular photoswitches fret two photon absorption multiphoton microscopy
Fabrication and Evaluation of SpinFET for Spintronics Applications (FESSA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

"Fabrication and Evaluation of SpinFET for Spintronics Applications” (FESSA) is a project that aims to demonstrate a miniaturized, low-power, and contact resistance engineered spin Field Effect Transistor (spin-FET) with a channel formed from a topological insulator (TI) rather than a conventional semiconductor material. Besides the opportunity for original results in materials science device physics, and it provides an innovative approach suitable for integrating into spintronic-CMOS hybrid circuits that address the need for low loss electronics to mitigate climate change. FESSA will use an interdisciplinary approach with multi-physics concepts to achieve a compact design with potential performance suitable for instrumentation systems for low noise, highly sensitive, rf/microwave, and mixed signal measurements/detection. The spin-transistor action will be achieved using gating effects to modify the spin transport properties of the TI channel between ferromagnetic (FM) source and drain contacts. FESSA will be achieved using high quality films deposited using the multi-chamber Royce deposition system (one of its kind) for efficient interface engineering, achieving low impedance mismatch at a TI/FM interface with high spin transparency. The fabrication of spin-FET will be achieved using Leeds Nanotechnology Cleanroom facility of ISO 5 (class 100) containing a range of state-of-the-art equipment to suit micro and nano-fabrication. Spin-FET action will depend critically on the TI/FM interfaces, and will be optimised electrical characterization with various geometries using the phenomenon of spin Hall effect and its inverse (STFMR, SHE, ISHE, non-local & AC/DC measurements, and GHz probe station measurement system). FESSA will have widespread implications in the field of high-speed operation capabilities and in the development of new hardware-based quantum and microwave devices with advanced device properties.

Keywords: spin field effect transistor topological insulator
Development of the next generation of 3D printed EMI shielding solutions based on 2D nanomaterials inks (2D-EMI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-08-01
End date: 2024-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

With the fast development of wireless communication, especially the new 5G technology, electromagnetic interference (EMI) shielding is becoming a challenge. High-performance EMI shielding materials are urgently needed in controlling electromagnetic radiation pollution that seriously affects the normal operation of sensitive electronic apparatus and systems. Metals are the most used shielding materials but suffer from easy corrosion, high density, and poor processibility. Despite the progress, most current research still concentrates on the solo enhancement of the EMI SE. To enable new EMI shielding applications for next-generation devices, multifunctionality and low reflection feature are also important for shielding material, which can significantly improve the application adaptability and reduce the secondary EMI pollution, respectively. Unfortunately, most of the present EMI shielding solutions cannot simultaneously integrate these characteristics. Therefore, pioneering alternative design and fabrication strategies for developing next-generation high-performance shielding materials beyond the usual protocols are urgently needed to meet the escalating demands of modern devices. Furthermore, as a critical component in electronic devices and equipment, EMI shielding materials also meet great challenges from the miniaturization aspect. 2D nanomaterials are promising for EMI-shielding applications due to their outstanding electrical, thermal, and mechanical properties, versatile surface chemistry and their favourable capability to be assembled into macroscopic architectures or serve as conductive fillers for composite fabrication. The aim of this project is to determine the economic and technical feasibility of using readily scalable additive manufacturing technologies for the development of highly efficient and customizable EMI shielding solutions based on two-dimensional (2D) nanosheets for electronic applications.