Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scaffolds for alternative delivery (SADEL)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Italy,France,Greece,France,Switzerland,Portugal,Denmark,Ireland,Austria
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 6482826.07
EU funding (EUR): 4951792.4
Participants: 10
Project status: CLOSED

The SME-based SADEL consortium intends to develop the first generation of oral bio-therapeutics tackling disease targets in the digestive tract, by making optimal use of the Nanofitin (Nf) protein scaffold. Nf based drugs will progress through routes not travelled by antibodies while interacting with targets not modulated by chemical compounds. Existing Nf hits against validated targets will progress to the preparation of Phase I Clinical trials in Ulcerative Colitis (UC). To achieve this, SADEL assembles a virtual biopharmaceutical company with SMEs (70%), academics, clinicians and pharma industry with all cutting-edge skills: production (including GMP), analytics, formulation, preclinical and clinical development, up to licensing. Nfs are small (optimal tissue penetration), exhibit strong resistance to pH and human intestinal fluids (long half-life in digestive track) and their high affinity implies low effective concentration. They also demonstrate strong potential for optimizing pharmacological properties, including reducing immunogenicity. The Nf based drugs will be administered orally, reducing the systemic exposure and avoiding the safety issues reported with systemic administration of antibodies. This requires large quantities of proteins for frequent administration. Nfs are produced in bacterial systems for which GMP-compliant processes are broadly adopted in the industry, with a low cost of goods. The resulting proteins will be formulated for optimal release at the sites of action. The project is designed to address unmet technical challenges while avoiding external risks beyond those related to the scaffold behaviour itself. All additional elements are chosen for documented validation, from targets to evaluation protocols. Achieving SADEL aims will solve unmet patient needs by providing affordable, safe, efficient products in a format raising comfort and compliance to treatment. It will also assess the therapeutic potential of the Nanofitin platform.

Keywords: scaffold,alternative delivery,nanofitin,affilogic,sadel
Development of gamma-TiAl forgings in a low-cost near conventional hot-die process and process evaluation (DAFNE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Austria,Austria
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-04-01
End date: 2014-09-30
Duration (months): 42.0
Total project cost (EUR): 639900.0
EU funding (EUR): 326250.0
Participants: 2
Project status: CLOSED

The strong need for higher efficiency, reduced CO2 emissions and weight reduction in aircraft engines leads to a demand of innovative light-weight high-temperature resistant materials which can partly substitute the materials currently employed. Presently, Ni-base alloys are used for turbine blades in aero-engines which satisfy the high mechanical and thermal requirements. A disadvantage of Ni-base alloys, however, is their high density of about 8 g/cm3. Intermetallic titanium aluminides, which exhibit a low density of about 4 g/cm3, are certainly among the most promising candidates to meet the required thermal and mechanical specifications. During the last decade several “wrought” gamma-TiAl alloys have been developed. These alloys exhibit excellent mechanical properties, but show a narrow processing window. Böhler Schmiedetechnik GmbH & Co KG (BSTG) is specialized on forging processes of materials like Ni-base and Ti-alloys for aero engine applications with a high demand on structure mechanical requirements. In cooperation with the department of physical metallurgy and materials testing at the University of Leoben as well as other project partners a novel Nb and Mo containing gamma-TiAl based alloy (TNM™ alloy) was developed. Due to optimized microstructure the alloy showed good malleability in first forging trials. An innovative approach of near conventional hot-die forging, which means that conventional forging equipment with minor and inexpensive modifications can be used, was made by BSTG. Aim of this project is to develop a robust low-cost near conventional hot-die forging process for low pressure turbine blades which meets on the one hand the requirements of the OEM and gives the right direction for future serial production on other hand.
Feasibility Study for a monitoring of progress in the activities of the Innovation Union performance in the domain of the European Research Area and its interaction with innovation. (ERA_MONITORING)

Framework: FP7 — Capacities
Programme: Support for the coherent development of research policies
Destination: Support for the coherent development of research policies
Action type: Coordination and support actions
Countries involved: European organisations area
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2011-05-01
End date: 2012-01-31
Duration (months): 9.0
Total project cost (EUR): 224300.34
EU funding (EUR): 200000.0
Participants: 1
Project status: CLOSED

The study will address the development and testing of three composite indicators to measure progress in: 1) construction and integration of a European Research Area (ERA), to monitor the overall performance of the Science and Technology system. 2) structural change, to monitor the increase of the knowledge component in the national economy of each Member State towards closing the technology gap in existing sectors of the economy. 3) research excellence, to monitor the results of policy actions aimed at strengthening research institutions in Europe. The methodology used will be that consolidated in the 2008 OECD-JRC handbook on composite indicators construction.

Keywords: indicators,composite scores,eu 2020,innovation union initiative,european research area
Composites under Fatigue: Temperature and Humidity Related Environmental Ageing Damage (CF-THREAD)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-10-01
End date: 2014-09-30
Duration (months): 36.0
Total project cost (EUR): 299665.2
EU funding (EUR): 224748.9
Participants: 1
Project status: CLOSED

This projects aims at substantially improving the understanding of the role played by environmental factors on the long term hydric fatigue endurance of fibre reinforced composites. This will be achieved by an extensive experimental campaign and the development of physically robust finite element based modelling techniques. The will allow predicting the onset of fatigue induced damage in laminates subjected to arbitrary temperature and humidity cycles. Such a modelling capability is the key for establishing equivalence factors between the actual conditions in which composite structural elements are required to operate and the characterization environment employed in the laboratory.

Keywords: composite accelerated fatigue testing,endurance,temperature,humidity
Integrated Design for Efficient Advanced Liquefaction of Hydrogen (IDEALHY)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Netherlands,Norway,United Kingdom,Germany,Germany,Switzerland,United Kingdom
Call:  (FCH-JU-2010-1, 2010)
Start date: 2011-11-01
End date: 2013-10-31
Duration (months): 24.0
Total project cost (EUR): 2117530.0
EU funding (EUR): 1295541.0
Participants: 8
Project status: CLOSED

Hydrogen is an important energy carrier as a viable future clean transport fuel. H2-fuelled vehicles are affordable, infrastructure investments are manageable and H2 and electric mobility are required to meet future CO2 emission targets. Plans are made to implement H2-refuelling infrastructure in Germany followed by roll-out over Europe by 2015. Logistically, liquid H2 appears the only viable option to supply the larger stations in the medium term. Without developing a liquefaction capacity, there is a serious risk to H2-infrastructure development and implementation. However, at present liquefaction of H2 is expensive, energy intensive and relatively small scale. Reduction of liquefaction costs via technology development and increased competition is crucial. IDEALHY is an enabling project for viable, economic liquefaction capacity in Europe, to accelerate rational infrastructure investment, and enable the rapid spread of H2-refuelling stations across Europe. The IDEALHY project researches, develops and scales-up data and designs into an optimised design for a generic liquefaction process at a scale of 30-50 te/day, representing a very substantial upscale over proposed and existing LH2-plants. The project also develops a detailed strategic plan for a prospective large-scale demonstration of efficient H2-liquefaction with options for location. The focus is to improve substantially efficiency and reduce capital costs of liquefaction through innovations, including linking LH2 production with LNG terminal operations to make use of available cryogenic temperatures for pre-cooling. Supporting economic and lifecycle assessment of the resulting gains in energy efficiency will be made, together with a whole chain assessment based on near term market requirements. IDEALHY will be undertaken by a partnership comprising world leaders in H2 distribution and liquefaction technologies, research institutes, academic partners and pioneering SME suppliers to the liquefaction indus

Keywords: hydrogen liquefaction efficiency up-scaling cost
Cost Competitive Component integration for StatiOnary Fuel Cell power (C3SOFC)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: United Kingdom,Germany,Italy,France,Belgium,Germany
Call:  (FCH-JU-2010-1, 2010)
Start date: 2011-10-01
End date: 2014-09-30
Duration (months): 36.0
Total project cost (EUR): 7868775.8
EU funding (EUR): 4001529.0
Participants: 6
Project status: CLOSED

Solid oxide fuel cells for stationary power have been researched since the late 1980s as potentially high efficiency and environmentally friendly means to generate electricity. Since that time substantial progress has been made however obstacles remain to reach industrial exploitation. For end users, the cost of electricity not only the cost of the fuel cell is of primary concern. This cost is driven by: the capital cost of the installed plant; the net plant efficiency that determines the fuel cost; the availability of the plant due to the reliability and ease of maintenance; and the emissions of pollutants including NOx and CO2 that may limit where the plant can be sited or incur additional costs. Most of these parameters are driven by the balance of plant which is hence critical to the success of SOFCs and to reaping their enormous benefits for Europe. Hybrid SOFCs offer the best potential for low cost and high efficiency but are also the most challenging in terms of balance of plant. Many components need to work together in a high temperature and pressure environment. Finding low cost and reliable solutions is therefore demanding and suitable ‘off the shelf’ components are not available. By changing the scale at which balance of plant functions are integrated, the C3SOFC project aims to develop solutions that satisfy the functional specifications of different users and achieve the corresponding measurable targets in terms of availability and cost. Large components with thermal expansion challenges will be reduced from system to block scale. Others requiring fabrication will be reduced to a scale where they can be integrated with other components manufactured by mass production techniques such as pressing. The future system architecture will be fault tolerant, greatly enhancing plant reliability. The final C3SOFC outcome will enable a technology and field demonstration that exceeds all the criteria of cost, performance and availability defined within the call.

Keywords: solid oxide fuel cell,balance of plant,components,hybrid,distribution,generation,carbon,emission,pollutants,technology,demonstration,generator,turbogenerator,stack,greenhouse,integrated
Wideband Quantum Optics with Josephson Junctions (WIQOJO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1640587.0
EU funding (EUR): 1640587.0
Participants: 1
Project status: CLOSED

Circuit quantum optics (quantum optics with microwave photons in electronic circuits) has allowed to solve several hard problems in traditional quantum optics and to explore new physics. However, so far only one of two regimes of circuit quantum optics has been explored, the circuit quantum electrodynamics regime, where photons reside in electrical resonators. In this project we want to develop the other regime of circuit quantum optics, the wideband regime, where photons are wave packets propagating along transmission lines. To do so we will build devices based on dynamical Coulomb blockade in Josephson junctions, a phenomenon relating tunneling of Cooper pairs to the emission and absorption of photons. This effect is well understood, but only DC current has been studied so far. We want to employ the photonic aspect of dynamical Coulomb blockade: Engineering the impedance seen by the junction and applying appropriate voltages allows to select specific single- or multi-photon processes that we want to use to build single photon sources, detectors and amplifiers and many other devices. Together they will fully enable wideband circuit quantum optics. The successful project will also extend the frequency range accessible to circuit quantum optics: Current quantum circuits can be operated only in a limited range around 5 GHz due to engineering constraints. Our approach lifts these constraints and the proposed devices should function in the range from a few GHz up to 1 THz. This extended frequency window will enable the development of hybrid quantum systems coupling quantum circuits to single dopants, molecules, quantum dots or other mesoscopic devices. The output of our project will also be helpful for other domains where radiation in the GHz to THz has to be measured at the single photon level, for example astronomy.

Keywords: circuit quantum optics
Van der Waals Interactions in Complex Materials (VDW-CMAT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 1356999.0
EU funding (EUR): 1356999.0
Participants: 1
Project status: CLOSED

Van der Waals (vdW) interactions are ubiquitous in nature, playing a major role in defining the structure, stability, and function for a wide variety of molecules and materials. VdW forces make the existence of molecular liquids and solids possible; they largely control protein-protein and drug-protein binding inside our bodies; they give geckos the ability to “defy gravity” attaching to walls and ceilings. An accurate first-principles description of vdW interactions is extremely challenging, since the vdW dispersion energy arises from the correlated motion of electrons and, in principle, requires many-electron quantum mechanics. Rapid increase in computer power and advances in modeling of vdW interactions have allowed to achieve “chemical accuracy” (1 kcal/mol) for binding between small organic molecules. However, the lack of accurate and efficient methods for large and complex systems hinders truly quantitative predictions of properties and functions of technologically relevant materials. We aim to construct and apply a systematic hierarchy of efficient methods for the modeling of vdW interactions with high accuracy and capacity to predict new phenomena in complex materials. Starting from quantum-mechanical first principles (adiabatic-connection fluctuation-dissipation theorem), we unify concepts from quantum chemistry (linear-response coupled-cluster and many-body perturbation theory), density-functional theory (ground-state electron-density response), and statistical mechanics (coupled-fluctuating-dipole model). Our final goal is to enable long time-scale molecular dynamics simulations with predictive power for large and complex systems of thousands of atoms. The project goes well beyond the presently possible applications and once successful will pave the road towards having a suite of first-principles modeling tools for a wide range of materials, such as biomolecules, nanostructures, solids, and organic/inorganic interfaces.

Keywords: van der waals interactions first-principles modeling of materials
New Directions in Dark Matter Phenomenology at the TeV scale (NEWDARK)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: ERC Starting Grant Interdisciplinary Panel
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-10-01
End date: 2018-09-30
Duration (months): 72.0
Total project cost (EUR): 1462200.0
EU funding (EUR): 1462200.0
Participants: 2
Project status: CLOSED

Dark Matter constitutes about 80% of the total matter of the Universe, yet almost nothing is known of its nature: despite the huge experimental and theoretical efforts of the last decades, its true identity is yet to be determined. The recent years and the next few years, however, see several experimental exploratory techniques approaching for the first time the TeV scale, in a multi-faceted attack to the problem: the Large Hadron Collider at CERN in particle physics, the PAMELA and AMS-02 satellites in charged cosmic ray astronomy and the FERMI telescope in gamma ray astronomy. Since general theoretical arguments lead to believe that Dark Matter is a particle inherently related to the TeV scale, the stakes are high of being finally close to the physics that holds the key of the puzzle. The NewDark project aims at exploring selected new directions in Dark Matter phenomenology, in a multi-disciplinary approach that has its roots in theoretical particle physics and cosmology but constantly looks at astrophysical observations and experimental particle physics results, making the most of the bi-directional interactions. The ultimate goal of the project, as part of the effort at the global scale, is the identification of the nature of the Dark Matter and the exploration of its full phenomenology. The project is organized around five main themes of Dark Matter research: theory model building, collider signatures, direct detection, indirect detection and astrophysical/cosmological implications. For each one of these, some selected groundbreaking objectives are identified. The emphasis is on new, non-traditional directions, building on the experience gained by the community in studying more traditional avenues and applying it to the new scenarios. The project requires funds to build up a small but structured multi-disciplinary research team (hiring 4 young post-docs with diverse expertise) and allow it to work on this frontier of astroparticle physics.

Keywords: dark matter theory,dark matter phenomenology,collider physics,charged cosmic rays,gamma rays,cosmology.
Fuel Control System Sensors and Effectors (CASE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom,Germany,United Kingdom
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-01-04
End date: 2014-07-03
Duration (months): 42.0
Total project cost (EUR): 1300000.0
EU funding (EUR): 688400.0
Participants: 3
Project status: CLOSED

This abstract highlights the approach taken to meeting the technical requirements of the call, the partnership with two SMEs, the European dimension of the proposal, and the inclusion of universities and specialist sub-contractors. AEC has identified specific technologies (eddy current and ultrasonic acoustic sensors, and piezoelectric actuators) as having significant potential for new forms of implementation in engine controls. AEC will extend this process of engagement with specialists to ensure state of the art technology is available for aerospace controls. Specifically within this programme: - AEC will develop new means of interaction between the metering system and the sensors and actuators - Micro-Epsilon Messtechnik, a German SME, will develop an eddy current sensor system for continuous monitoring and proximity sensing - Oxford Radio Frequency Sensors, an SME closely linked to Oxford University Clarendon Laboratory, will develop piezoelectric acoustic mass flow measurement developed from recent advances in medical physics - AEC will pull through work already committed with Newcastle University to develop piezoelectric acoustic position sensing, also drawing on research work underway with Leeds University. Some of this design and manufacturing work will probably be sub-contracted to a Danish specialist company, Noliac - AEC will also pull through work already underway with Bath University to develop a new generation of piezoelectric actuators with the potential to actuate both direct drive and servo-system control of aerospace fuel systems - AEC will carry out whole system environmental testing on in house test facilities normally used for the development and qualification of civil and military fuel control systems for production application All these systems will be compact, robust, reliable, and precise by virtue of the base technologies that are being applied, and also due to the design capability within AEC to design fit for purpose aerospace controls.

Keywords: compact,robust,reliable,aerospace,sensors,effectors,actuators,piezo,acoustic,eddy current,trl6.