Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
All-in-one solar rechargeable Zinc-air battery enabling direct storage of solar energy (HESOZA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: CLOSED

As photovoltaics (PV) technology develops rapidly, solar energy conversion and storage devices such as solar rechargeable batteries are also becoming more viable to compensate for intermittent sunlight. Considering their working life, cost, energy density, safety and eco-friendliness, rechargeable Zn–air batteries (ZABs) are regarded as a promising candidate for next generation advanced energy devices. Solar rechargeable ZABs would effectively convert and store solar energy in one two-electrode battery, simplifying the configuration and decreasing the external energy loss. Yet, there are several major challenges to widespread adoption of solar rechargeable ZABs: (i) low efficiency due to lack of high performance photoactive electrode capable of light harvesting and energy storage, (ii) instability and low cycle life due to anode-electrolyte side reactions. This proposal will develop for the first-time ZABs with solar-charging capabilities through combinatorial designing of a bifunctional high entropy material (HEM) photocathode-catalyst, fabricating a gradient nanoporous fluorinated zinc-tin (FZT) anode and optimizing electrolyte composition. Such a configuration enables to decrease the charge overpotential of ZABs below the theoretical voltageof 1.65 V. More importantly, it directly stores solar-to-electrochemical energy. Therefore, the main goal of this proposal is to boost the efficiency and stability of solar rechargeable ZABs by taking advantages of HEM concept i.e., numerous active sites, sluggish diffusion, and enabling much improved plating/stripping cycling on FZT anode through a 2e−/O2 process in nonalkaline aqueous electrolyte. HESOZA’s achievements will make advancements on cutting edge direct solar-to-electrochemical energy storage in a simple two-electrode cell configuration that are pivotal to reach EU’s environmental targets for a reliable and green energy transition at low-cost.

Keywords: rechargeable zinc air batteries,solar energy storage,high entropy materials,combinatorial
Irritation and Human Sociality (IRRITATION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1499738.0
EU funding (EUR): 1499738.0
Participants: 1
Project status: SIGNED

Irritation is a pervasive feature of the human experience, and of human sociality in particular, yet it has been very little studied by social and natural scientists. Research on irritation as it bears on interpersonal relationships, rather than as a physical reaction to a sensory experience, is particularly thin. This project investigates irritation as a feature of human sociality in diverse cultural contexts, with a particular focus on issues related to cooperation and morality. It brings together methods and approaches from anthropology and psychology, combining in-depth ethnographic research in four culturally distinct environments with methods of systematic experimental comparison. The primary aim of this project is to develop a comprehensive account of irritation that brings together the social, cultural, and psychological dimensions of it, and of emotional life more generally. The secondary aim is to bring the analysis of irritation into dialogue with the analysis of two fundamental features of human sociality: cooperation and morality. On the one hand, it might be felt that irritation is a threat to our close relationships; that if taken too far it will compromise the very patterns of cooperation and care on which these relationships depend. And yet the pervasiveness of irritation, not least among very close kin, suggests something else: that in some sense we may need irritation – even that it is a constitutive feature of human sociality. Investigating the role irritation plays in the maintenance and disintegration of cooperative relationships, and in moral judgements, will enlarge our understanding of the emotional side of human sociality. This pioneering work will develop a sophisticated, culturally grounded theory of irritation, capable of entering into critical dialogue with mainstream psychological and evolutionary theories of human sociality, and make broader methodological contributions to studies of intimate experience and emotional life.

Keywords: irritation,sociality,emotion,cooperation,morality,mixed method,psychological anthropology,ethnography,experiments,cross cultural comparison
Hyper-Realistic Models for Hands-On Surgical Training in Non-human Primate Biomedical Research (PRISM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands,Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 175714.29
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

The PRISM project addresses critical challenges in neurosurgical training involving non-human primates (NHPs) within the framework of the 3Rs (Replacement, Reduction, Refinement) endorsed by the EU. NHPs are indispensable models in biomedical research, particularly in neurosciences, due to their close phylogenetic relationship with humans. However, invasive procedures on NHPs, including cranial surgeries and targeted ablations, pose ethical dilemmas and require highly skilled personnel. This project introduces a groundbreaking solution by developing the first hyper-realistic model for hands-on surgical training in NHPs. Collaborating with UpSurgeOn, experts in 3D simulation for human neurosurgery, PRISM aims to create a safe and ethical training environment for young researchers working with NHP. The project's objectives include the design of a hyper-realistic NHP model, the organization of pilot courses, and devising strategies for commercialization. PRISM promises enhanced visualization, tactile learning experiences, customizability, and ethical training, ultimately fostering career development, animal welfare, and research quality. Successful implementation will set a new standard in NHP neurosurgical education with global potential.

Keywords: 3r,non human primates,cranial surgery,training
TRANSFORMING AFRICA’S URBAN FOOD ENVIRONMENTS THROUGH STRENGTHENING LINKAGES BETWEEN FOOD SYSTEMS STAKEHOLDERS IN CITIES ACROSS EUROPE AND THE CONTINENT (AfriFOOD-Links)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: South Africa,Germany,Italy,Netherlands,Belgium,Uganda,France,Ghana,Kenya,Burkina Faso,Tunisia,Mauritius,United Kingdom
Call: African food cities (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 11816305.09
EU funding (EUR): 11816305.09
Participants: 31
Project status: SIGNED

AFRIFOOD-Links AfriFOODlinks aims to improve food and nutrition security, while delivering positive outcomes for climate and the environment, and building social and ecological resilience in 65+ Cities (15 African and 5 European Implementation cities and 40+ Network Cities) cities by: 1) applying an urban food systems lens to promote shifts to healthy, sustainable diets, 2) transforming urban food environments through real-world socio-technical experiments; 3) promoting inclusive multi-actor governance to empower public officials, small businesses and communities with ownership and agency to shape their food systems; and 4) accelerating innovative, women- and youth-led agri-food businesses to support local value addition and inclusive economic participation. AfriFOODlinks invests in direct food system change in 5 African Hub Cities, and invites 10 African and 5 European Sharing Cities to join the Hub Cities on a mutual-learning journey, to share their innovative food systems and to co-design specific pilot projects for implementation in each Sharing City. Researchers, posted within each of the 20 local governments, will support the city to articulate its identified food system challenges and own authentic approach to improving access to healthy, nutritious food - with a particular attention to vulnerable groups - and reducing food related environmental impacts through food systems intervention. In this way, these implementation cities become flagships - beacons of inspiration for urban food systems transitions across the continent to inspire and share with over 40 Network cities, who are invited to adopt and adapt.

Keywords: urban food systems,urban food environments,multi actor governance,agri food businesses,inclusive economic participation,social and ecological resilience
Electrobiocatalytic cascade for bulk reduction of CO2 to CO coupled to fermentative production of high value diamine monomers (ECOMO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,Denmark,France
Call: EIC Pathfinder Challenge: Carbon dioxide and Nitrogen management and valorisation (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 3784201.25
EU funding (EUR): 3776701.25
Participants: 5
Project status: SIGNED

The access to platform chemicals made of CO2 and nitrogen sources as starting materials via sustainable processes requires radical innovations. Driven by the global need of existing and growing markets, combined technologies that make use of renewable energy and the greenhouse gas CO2, and the use of nature’s catalysts such as enzymes and microbial cells through biotransformation steps are expected to have a game changing impact. Such catalysts can operate at ambient conditions at high atom efficiency through environmentally and energetically friendly processes. In this context ECOMO unites bioelectrocatalysis, biohybrid materials sciences, organic synthesis, technical microbiology, and process engineering for CO gas fermentation to acetate and a subsequent production of diamines. The fermentation steps will be achieved by specifically engineered microbial strains using CO as both the carbon source and energy carrier. As core novelty, the CO will be produced in situ apart from the electrode in the bulk solution from CO2 through a mediated electron transfer to free floating beads where CO-dehydrogenase is immobilized within the acetate forming bacterial cell culture. This will enable for the first time, full compatibility between electrochemical and biocatalytic processes. The synthetic aim is to yield high value-added diamine monomers as building blocks for established classes of polymeric materials. ECOMO will establish new bio based and biohybrid modules that will be directly compatible with the existing bioreactor infrastructure for the producing of specialty chemicals directly from CO2. By achieving the production of diamines as a proof-of-concept, ECOMO will foster further diversification to many other products made from CO2 and thus enhances the synthetic availability of needed building blocks for the chemical industry. The decoupling from fossil-sourced energy and raw materials underpin the timeliness of ECOMO.
Exploring the role of heterochromatin regulation in spermatogenesis through a Sex Ratio meiotic drive system in Drosophila (HetY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 2
Project status: SIGNED

Spermatogenesis is a crucial and intricate biological process for species continuity. The sex ratio (SR) meiotic drive system, prevalent in many organisms, skews offspring sex ratios by manipulating sex chromosome inheritance during meiosis. While the underlying molecular mechanisms remain elusive, recent studies suggest that heterochromatin regulation may hold a central role in most SR systems. The HetY project aims to uncover the role of heterochromatin regulation in spermatogenesis by exploiting a natural meiotic perturbation : the Paris SR system in Drosophila simulans. This system is characterized by sister chromatid nondisjunction of Y chromosomes during meiosis II, induced by two X-linked drivers, including a malfunctioning Y-linked heterochromatin protein. We hypothesize that misregulation of Y heterochromatin is responsible for this nondisjunction. Our first objective is to identify the target(s) of the X-linked driver, using advanced CUT&Tag techniques. Some Y chromosomes resist to drive, potentially due to their intrinsic ability to evade perturbations of their heterochromatin landscape. Our second objective is to characterize those perturbations, through a comprehensive transcriptomic analysis to pinpoint extensive changes in heterochromatin landscapes. Recent findings indicate that the resistant ability of Y chromosomes correlates with their simple satellite repeat composition, and studies suggest that simple satellite expression is essential for male fertility. Our third objective is to probe the role of simple satellite RNA in chromatin organization and spermatogenesis. To this end, we will design shRNA against simple satellites identified in our previous study, assessing their influence on the sex ratio phenotype and potential induction of morphological defects during spermatogenesis. Our analyses will illuminate the interplay between heterochromatin regulation and spermatogenesis, offering new insights into these essential biological processes.

Keywords: spermatogenesis heterochromatin meiotic drive genetic conflict sex chromosome drosophila satellite repeat
Leveraging Early Adolescence for Development: Longitudinal and Experimental Evidence from Ghana (LEAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Spain,United States,Ghana
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1638020.25
EU funding (EUR): 1638020.0
Participants: 3
Project status: SIGNED

Early adolescence is a key window for human development. Strategic timing of interventions during this life stage may seize opportunities and prevent risks; bolster the impact of earlier investments; and ease damages from previous adversity. Yet evidence on whether such programs can fulfil this potential, for which children, and through which channels, is scant, especially in low-resource settings, where 90% of the world’s 1.2 billion adolescents live. I will tackle these gaps by relying on a cohort of ~2,500 children approaching early adolescence. In 2015, this sample participated in a trial evaluating quality preschool education in Ghana and has been followed-up since: the program improved child development through middle childhood. I will re-randomise this sample at 12 years to test a parenting skills program to enhance early adolescent development through improved parenting support and parent-adolescent interactions. Children and parents will be re-interviewed when children are 13, 15, and 17 years through mixed-method data collection. Outcomes include adolescent social-emotional and academic skills, health (including stress biomarkers), and adult-life transitions. This data will allow testing dynamic complementarities between interventions during early childhood and early adolescence, or whether interventions in adolescence might compensate for earlier adversity in the short- and longer-term. Methodologically, these questions can be convincingly studied only if data are available for the same individuals over time, and if variations in exposure to early childhood and early adolescence programs are exogenously driven. This is the first study that addresses both requirements, providing a breakthrough. Heterogeneity by child gender and socioeconomic status, and mechanisms are further research foci. LEAD’s high-risk components are well-balanced by my in-depth knowledge of the field, methods, and study context, with high potential for scientific and societal impact.

Keywords: human development early adolescence early childhood intervention research child development child poverty inequality learning social emotional skills health health behaviour low and middle income countries gender social policy for children and adolescents in developing countries child development in context risk and resilience for children in situation of adversity lifecourse
Novel engineered cytokines for human therapy (Cytodesign)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cytokines are biomolecules of great potential interest for human therapy. They modulate the immune system and play an important role in cancer, inflammation, immune response and tissue regeneration. Despite their great potential, there are only a handful of cytokines approved for therapeutic purposes. This is because many of them can have adverse side effects as they usually target different cell types, which adds to their low serum half-life, high production costs, or lack of physiological efficacy. Different methods have been proposed to improve the pharmacodynamics and pharmacokinetics of selected cytokines. However, other properties do also need improvement, such as achieving effective local concentration at the target site; promoting the right activity in cytokines with dual functionality and decreasing toxicity by removing binding to unwanted cell types. To help solving these issues, we have developed a new protein design strategy that can be applied to all helix-bundle cytokines, many of which have been shown to be therapeutically relevant. The resulting products are uniquely modified cytokines with improved properties. Amongst such properties, our products show increase stability, higher affinity and specificity for their target receptors and should have reduced toxicity, all of which translate into greater safety and efficacy. We have initial evidence both (in vitro and in vivo) of the superiority of our designs over conventional cytokines, and in this project we will fully validate our technological platform and advance in the development of a business plan following the advice of several venture capital and pharma companies contacted to date, with the idea of laying the basis for the creation of a new start-up company.
Five pillars to DECARBOnize the last MILE logistics (DECARBOMILE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: France,Germany,Denmark,Spain,Bulgaria,Italy,Türkiye,Belgium,Poland,Estonia,Bosnia and Herzegovina
Call: New delivery methods and business/operating models to green the last mile and optimise road transport (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 9562521.25
EU funding (EUR): 7963993.63
Participants: 32
Project status: SIGNED

Gathering 31 partners from 10 different countries, DECARBOMILE aims to trigger an unprecedented improvement of the green last mile logistics in Europe. To reach that goal, DECARBOMILE relies on a strong experience of decarbonating urban logistics through European initiatives such as CIVITAS. Partners will build upon all previous results to develop improved delivery methods, tools and methodologies, and implement them across Europe. The solutions developed in DECARBOMILE will demonstrate the full potential of decarbonised last mile logistics in four living labs (in Logrono - Spain, Nantes -France, Hamburg - Germany and Istanbul - Turkey) and 4 satellites (Tallinn - Estonia, Getafe - Spain, Ghent - Belgium and Sarajevo - Bosnia and Herzegovina) will be involved at a smaller scale to test and study the solution in their own local contexts. To be successful in its implementation, DECARBOMILE will rely on developed methodologies to implement the new solutions and delivery methods in collaboration with all relevant local stakeholders, based on their needs and behaviours. The relation with and between stakeholders will be facilitated by the creation of a collaborative urban consolidation logistics framework that will include a digital platform, methodologies for collaboration, and ICT and IoT tools. This common framework, along with tailored innovative business models and recommendations on local policies, will allow for a strong collaboration during the project, allow to learn more about the end-users’ needs and behaviours. The delivery methods will be strongly improved with urban consolidation centres, micro urban consolidation centres including smart lockers, innovations on cargo bikes and how they can be used with load pooling for instance, electric barge and more. The goal is to use and improve existing solutions and allow their interoperability and modularity to improve their efficiency and use their complementarity.

Keywords: last mile,logistics