Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rituximab in Acute Myocardial Infarction (RITA-MI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-03-01
End date: 2018-08-31
Duration (months): 30.0
Total project cost (EUR): 149402.0
EU funding (EUR): 15266.0
Participants: 2
Project status: CLOSED

Cardiovascular diseases (CVD) represent a major cause of morbidity and mortality. The best current therapy reduces CV risk by only 25-30% and remains ineffective in reducing the excess risk associated with several co-morbidities. Therefore, there is considerable need for new therapies to limit the burden of CVD. Based on a current ERC Starting Grant project, the applicant’s group proposed and validated the concept that mature B lymphocytes are instrumental in the orchestration of the inflammatory response after ischemic myocardial injury, in part through production of CCL7 chemokine and mobilisation/recruitment of inflammatory monocytes to the infarction site (Zouggari Y et al., Nat Med 2013). Our goal now is to translate this ground-breaking discovery and novel therapeutic concept into benefit for patients. The overall objective of the RITA-MI project is to develop a new and cost-effective therapy for patients with acute myocardial infarction (MI) based on selective targeting of the B cell immune response, with the ultimate aim to substantially reduce the high risk of death and major cardiovascular events associated with the disease. Interestingly, the drug, CD20 monoclonal antibody (mAb) rituximab, is readily available for testing in a re-purposing scheme, allowing for rapid initiation of this proof-of-concept clinical trial. Working Hypothesis: A single infusion of rituximab at the acute phase of MI is safe, substantially depletes circulating B cells, and has the potential to limit infarction size and improves myocardial heart function. Overall objective: Does a ‘fire and forget’ approach with rituximab (a single intravenous infusion) reduce infarct size and/or improve heart function in patients with acute STEMI? The overall aim will be pursued through a series of specific objectives, which will correspond to a first step of a dose-finding proof-of-concept study (the present RITA-MI project), followed (if successful) by a phase II clinical efficacy trial.

Keywords: myocardial infarction,lymphocytes,rituximab
Isotope Fractionation of Light Elements Upon Ionization: Cosmochemical and Geochemical Implications (Photonis)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 2810229.0
EU funding (EUR): 2810229.0
Participants: 2
Project status: CLOSED

Light elements such as hydrogen and nitrogen present large isotope variations among solar system objects and reservoirs (including planetary atmospheres) that remain unexplained at present. Works based on theoretical approaches are model-dependent and do not reach a consensus. Laboratory experiments are required in order to develop the underlying physical mechanisms. The aim of the project is to investigate the origins of and processes responsible for isotope variations of the light elements and noble gases in the Solar System through an experimental approach involving ionization of gaseous species. We will also investigate mechanisms and processes of isotope fractionation of atmophile elements in planetary atmospheres that have been irradiated by solar UV photons, with particular reference to Mars and the early Earth. Three pathways will be considered: (i) plasma ionisation of gas mixtures (H2-CO-N2-noble gases) in a custom-built reactor; (ii) photo-ionisation and photo-dissociation of the relevant gas species and mixtures using synchrotron light; and (iii) UV irradiation of ices containing the species of interest. The results of this study will shed light on the early Solar System evolution and on processes of planetary formation.
Cinematographic story-telling, super-zoom, x-ray, infrared (IR) ultraviolet (UV) gigapixel enriched content and cross-museum digital content licensing platform enhancing EU museums competitiveness (scMODULES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 1681281.25
EU funding (EUR): 1176896.88
Participants: 1
Project status: CLOSED

There are 36,000 museums in the EU, but only 25% of them have at least one publication in digital format. The main barrier for museums to become digital are (1) the high costs that tailor-made solutions imply; and (2) the low quality and poor user experience that low-cost apps and guides offer. There is a huge untapped business potential in the digital transformation of museums that have still not gone digital as well as in those that have implemented some channels but not a complete 360º solution. The ambition of Madpixel is to respond to this need and exploit this clear market opportunity by taking to the market a highly scalable and cost-efficient product (scMODULES) based on MADPIXEL disruptive technologies, knowledge and experience in the field of art digitisation and digital content management. scMODULES will allow museums to easily go digital improving visitors’ experience with enriched interactive content (X-ray, IR, UV, super-zoom, story-telling), extending museum reach much beyond the physical visit. It will also increase museums cultural offer through digital exhibitions creating a new revenue stream based on licensing digital enriched content to other museums. scMODULES will be offered as a modular SaaS solution offering a complete set of tools that totally cover museums needs from a digital perspective at a fraction of current tailor-made solutions. scMODULES will become a game-changer leap forward in cultural content consumption, management, publication and cross-museum licensing and exploitation. Madpixel expects that by 2022 scMODULES will be the reference solution for museums to go digital with almost 1,750 museums registered and +165,000 art-woks digitalised. Thanks to scMODULES Madpixel will hire 40 additional people, the annual turnover will be around 12M€ and cumulated EBITDA will be +11,5M€. Profitability indicators are very positive with 56% Internal return rate (IRR) and 3.5 M€ as Net Present Value (NPV).

Keywords: art digitalisation,gigapixel,infrared,untraviolet,enriched interactive digital content,virtual,museum,cinematographic story telling
Adaptable Reactors for Resource- and Energy-Efficient Methane Valorisation (ADREM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Belgium,Belgium,Slovenia,France,Netherlands,Netherlands,United Kingdom,Denmark
Call: New adaptable catalytic reactor methodologies for Process Intensification (H2020-SPIRE-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 5999933.75
EU funding (EUR): 5999933.25
Participants: 10
Project status: CLOSED

In ADREM, leading industries and university groups in process intensification, catalytic reactor engineering and process control team up to address the domain of resource- and energy-efficient valorisation of variable methane feedstocks to C2+ hydrocarbons. The development of new and intensified adaptable catalytic reactor systems for flexible and decentralized production at high process performance is in focus, able to operate with changing feedstock composition and deliver “on-demand” the required product distribution by switching selected operational/control parameters and/or changing modular catalyst cartridges. In the long term, we expect the reactors to operate energy- and emission-lean using green electricity as the direct, primary energy source. In order to converge to the optimal design, the project will utilize the unique integral, four-domain process intensification (PI) methodology, pioneered by the consortium. This is the only approach able to deliver a fully intensified equipment/process. The key feature is the systematic, simultaneous addressing of the four domains: spatial, thermodynamic, functional and temporal. ADREM will provide: • highly innovative, economic and environmentally friendly processes and equipment for efficient transformation of methane into useful chemicals and liquid fuels, for which monetary savings of more than 10% are expected. • process technologies applying flexible modular one-step process with high selectivity for valorisation of methane from various sources. • modular (and containerized and mobile) reactors permitting flexible adaptation of the plant size to demand and also utilizing smaller or temporary sources of methane or other feeds. The project will employ emerging reactor technologies coupled to especially designed catalytic systems to address a variety of scenarios embodying methane valorisation. The concepts developed can be later readily extrapolated on other types of catalytic processes of similar sizes.

Keywords: process intensification methodology,vital valorisation,modularity of modular reactor,renewable electricity based processes,on demand product control,reactor mobility
Functional analysis of Stress Granules formation in plant adaptation to stress (reSGulating)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Environmental stresses are the primary causes of crop loss worldwide, reducing average yields for most major crop plants by more than 50%. To get an optimal adaptation to environmental threats, plants have evolved a variety of complex and efficient mechanisms of resistance, including compartmentalization of mRNAs and proteins in cytoplasmic structures known as Stress Granules (SGs). In these, mRNA molecules are stored, degraded or kept silent in order to prevent energy expenditure on producing useless proteins, promoting thus the translation of specific stress-responsive genes that lead to the recovery from stress. Despite their importance in cell fitness, the overall composition of SGs, as well as their assembly requirements and regulation remain largely unknown. Although SGs have been found to be evolutionary conserved between species, the current knowledge of how plant SGs can regulate and modulate the response to stress is still limited. The overall objective of this proposal is to increase our understanding of the fundamental function of SGs on the regulation of plant response to stress. To this end, a compendium of methodologies including genetic and cell biology will be implemented in order to identify and characterize mutants impaired in SGs formation, taking advantage of well-established photosynthetic model systems such as Arabidopsis thaliana and the green alga Chlamydomonas reinhardtii. Given that autophagy is a core mechanism that governs the regulation of SGs formation, disassembly or clearance in animal and yeast models, this molecular link will be studied in higher plants. It is anticipated that implementation of this project will provide novel insights into SGs biology, helping to enhance our knowledge on the modulation of stress responses. Besides, the proposed project is endowed of solid formative contents that will strengthen my previous experience, boosting my future scientific career and paving the way for closer scientific collaborations.

Keywords: stress granules,mrna cycle,post transcriptional modifications,global genetic screen,arabidopsis,plant cell biology
“World’s first techno-economic viable recycling technology for waste woodboards” (FibreCarb)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Belgium
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Mankind uses wood as a raw material since the stone age. It has been perceived to be an abundantly available even renewable resource, it literally grows everywhere and people have a natural tendency to apply wood for their everyday use in many ways Nevertheless, Recently, demand for wood and wood-based products are significant increasing, not only for reaching the renewable energy target but also for bio-products for biorefineries. Unfortunately, many of these products have become nowadays commodity products with “short” lifespans. They still have not found their way to be fully reused or recycled, lacking appropriate techno–economic solutions. One of these commodity products - being produced at 11.000.000 ton/year and resulting in 10.000.000 m³ of landfilled material – is fibreboard (MDF board), one of the wood-board types used in many cheaper type of furniture. Act&Sorb developed a technology that addresses the societal challenge by having identified a high value large market– the wood based activated carbon market – currently using also fresh wood! Act&Sorb has been able – aligned with its overall vision and strategy – to design the MDF waste treatment process in such a way that the component within the MDF waste causing it to be difficult to be recycled – the glue – is turned into a valued resource – enabling the production of nitrogen incorporated wood-board waste activated carbon, a specialty product with high market value. The concept has the potential to treat the full amount of fiberboard waste while eliminating the need for fresh wood for the production of wood based activated carbon.

Keywords: wood waste,woodboard,fibreboards,mdf board,activated carbon
Disability Advocacy Research in Europe (DARE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Iceland,Germany,Belgium,Belgium,Switzerland,Switzerland,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 3845925.4
EU funding (EUR): 3845925.4
Participants: 19
Project status: CLOSED

DARE will train a new generation of disability scholars and policy specialists. It sets out an ambitious research programme, providing interdisciplinary, intersectoral training which will equip the ESRs to have a real impact on law and policy reform and on the real lives of persons with disabilities. The goal of DARE is to give legitimacy, through research, to the lived experience of persons with disabilities, as a basis for law reform. This is not just a desirable policy goal - it is legally required by the UN Convention on the Rights of Persons with Disabilities which is binding in the EU alongside its Member States. DARE innovates intersectorally by bringing non-academic partners into the very heart of the research and training programme as co-supervisors of the ESRs. It innovates intersectionally by emphasising how various identities (such as gender and age) interact to create layers of discrimination against persons with disabilities. It innovates by training the ESRs in emancipatory and participatory research methods to ensure that the voices of persons with disabilities take centre stage in the research process. It will require the ESRs to adopt a lifecourse perspective in developing an evidence base for law and policy reform. Through a carefully tailored secondment strategy in the advocacy community, DARE will expose the ESRs to organisations outside academia and at the epicentre of reform. DARE will draw on a panel of international policy & disability experts to enable the ESRs to continually refine their research to ensure it has societal impact. DARE will make Europe a highly attractive educational space for research on the implementation of the UN Convention. It will give the ESRs a decisive advantage in seeking new employment roles in processes of reform at the international level, before Governments and in advocacy groups. Its graduates will be seen not merely as traditional ‘knowledge providers’ but also as ‘policy entrepreneurs.’

Keywords: disability,policy,inter disciplinary,voices,human rights,social change,inter sectoral
Efficiently Networking European Neurodegeneration Research (NEURONET)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Coordination and support actions
Partnership: IMI2 (Art-187)
Countries involved: Spain,Switzerland,Switzerland,Belgium,France,United Kingdom,United Kingdom,United Kingdom,Luxembourg
Call: Support and coordination action for the projects of the Neurodegeneration area of the Innovative Medicines Initiative (H2020-JTI-IMI2-2017-13-two-stage, 2017)
Start date: 2019-03-01
End date: 2022-08-31
Duration (months): 42.0
Total project cost (EUR): 2353125.0
EU funding (EUR): 1199125.0
Participants: 10
Project status: CLOSED

The main aim of NEURONET is to set up an efficient platform to boost synergy and collaboration across the IMI projects of the Neurodegenerative Disorders (ND) portfolio, assisting in identifying gaps, multiplying its impact, enhancing its visibility and facilitating dovetailing with related initiatives in Europe and worldwide. This will be achieved through the following specific objectives: 1) creation of an overall platform for efficient collaboration, communication and operational synergies among present and future IMI ND projects; 2) designing systems to map and analyse information regarding actions, initiatives and partnerships, assessing impact of the individual projects, remaining gaps and global value of the programme for stakeholders; 3) supporting the management of the programme (timelines, dependencies, synergies and key results across projects); 4) proactively detecting needs, opportunities and transferable best practices of projects and to connect them; 5) providing support to the projects by organising tools, services, expert advice and guidelines/recommendations on common issues; 6) promoting enhancement and coordination of communication across the IMI neurodegeneration projects, increasing programme visibility, outreaching to key stakeholders and establishing relationships with initiatives in the field; and 7) preparing and securing the long-term sustainability of NEURONET itself. Achievement of these objectives will necessarily rely on buy-in from existing and future projects in the IMI ND portfolio, and effective connections with other programmes and initiatives in Europe and beyond, including stakeholder representation. For this, the Consortium has been constituted by very active partners in a variety of IMI ND projects and related initiatives with specialists in areas like complex/project management, data sharing & re-use, drug development, patient engagement, communication, sustainability and regulatory/HTA interactions.

Keywords: platform,imi neurodegeneration project portfolio,programme management,sustainability,expert advice,regulatory and hta engagement,communication,mapping and impact analysis,data sharing and privacy
Energy efficient Mortgage Market Implementation Plan (EeMMiP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Germany,Italy,Italy,Belgium,United Kingdom,Denmark
Call: Mainstreaming energy efficiency finance (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-09-01
End date: 2023-02-28
Duration (months): 30.0
Total project cost (EUR): 1767177.5
EU funding (EUR): 1500000.0
Participants: 7
Project status: SIGNED

The European Union (EU) has set itself ambitious climate change targets. The scale of investment needed to meet the energy savings targets alone is estimated at €180 billion p.a., three quarters of which is accounted for by energy efficiency in buildings. In light of the link between buildings and mortgages, the EU-funded Energy Efficient Mortgages Initiative (EEMI)[1] sought to bridge some of this gap by way of the energy efficient mortgage (EEM) product and framework. However, experience gained indicates the development of the EEM market goes far beyond designing the product and requires the integration of a complex web of stakeholders. The Energy Efficient Mortgage Market Implementation Plan (EeMMIP) will build on efforts to develop EEM by delivering an integrated market and a blueprint for established and emerging markets around the globe. The Project will conduct an analysis of the current market systems relevant to the development of an EEM market and establish demonstrators to support the demonstration of the end-to-end customer journey and EEM life-cycle. It will establish market-based governance and an EEM Label to support recognition of and confidence in EEM and facilitate access to quality information for market participants. It will deliver guidance for the inclusion of energy efficiency in credit risk assessments for lending institutions and supervisors and policy recommendations for the prudential framework in line with the principle of risk sensitivity and promote a well-functioning banking market. Finally, it will support global take-up of EEM through the Label and institutional cooperation. EeMMIP responds to the objectives of the EU in the areas of sustainable finance and climate change, all against the background of Capital Markets Union, and aims to influence the entire value chain, from consumer to bond investor, stimulating mentality change and securing energy efficiency in market attitudes and best practices both in Europe and globally.

Keywords: energy efficiency,mortgage lending,building stock,sustainable finance,asset screening,transparency,risk management,capital markets union,basel committee,capital requirements regulation