Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Literary Attention in Short Fiction, or: What Literature Knows About Attention and Attention Politics (LitAttention)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2498905.5
EU funding (EUR): 2498905.0
Participants: 1
Project status: SIGNED

Literature knows a lot about attention – how it is gained and retained, how it is mastered and manipulated. As such it can contribute significantly to current research in interdisciplinary attention studies, transform debates about attentional crises, and offer deep insight into attention regimes we live by. LitAttention explores this fundamentally under-researched knowledge domain of literature about attention and attention politics by analysing ‘literary attention’ in short fiction. As LitAttention will show, short fiction does not only cater to short(er) attention spans: its development was driven by attention anxieties and struggles for attention control, which responded to technological innovation, new streams of information, the rise of attention studies, changing modes of reading, growing concerns about the limits of human attentional capacities, and intensifying struggles for attention sovereignty. Integrating approaches from educational psychology, computational linguistics, and literary and cultural studies, LitAttention has four key objectives. It will (1) examine the various ways in which short fiction has been shaped by but also shaped discourses on attention and attention management; (2) analyse the poetics and politics of attention in short fiction by identifying syntactic, semantic, and narrative strategies that elicit attention, and assess how these narratives reflect upon, support, or subvert attention regimes of their time; (3) develop (transferable) methodological and conceptual frameworks for examining literary attention; (4) introduce the important role of literary attention for education. The project is the first to conceptualize literary attention and propose a networked approach for its analysis. Its results will reveal the crucial role of short fiction in changing ecosystems of attention, have a deep impact on education, and change the way in which scholars, teachers, and the general public approach the knowledge and value of short fiction.

Keywords: literary attention,short fiction,short story,microfiction,attention economy,cultural ecology,digital culture,mind wandering,education
Maintenance, Support & Operation Training using Immersive Virtual and Augmented Technology for Efficiency with XR (MOTIVATE XR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Innovation actions
Countries involved: Italy,France,Ireland,Greece,Spain,Netherlands,Slovenia
Call: eXtended Reality for Industry 5.0 (IA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 7378970.5
EU funding (EUR): 5993041.75
Participants: 20
Project status: SIGNED

XR has the potential to revolutionize various industrial sectors by offering more engaging, secure, and inclusive training and assistance for complex tasks thus enabling more people to acquire the skills required to perform such tasks. However, the creation of such XR experiences is still overly complex, time consuming, and expensive thus blocking their wide adoption in industrial sectors that do not have the necessary expertise nor the resources to create and deploy them. The main objective of MOTIVATE XR is to create a world’s leading XR collaborative authoring, publishing, and experiencing tool suite for training and assistance to industrial operations such as the assembly, manufacturing, maintenance, and dismantlement, of industrial goods. This ground-breaking, open, tightly integrated, and highly interoperable solution will be designed for, and usable by a wide range of users without programming skills, from the largest European industrials to handywomen/handymen, without requiring software development skills. It will offer an end-to-end solution to streamline the whole authoring and experiencing workflow thanks to novel portable 3D scanning and digital twin modelling solutions, No-Code authoring approaches and ground-breaking XR experiencing tools, including a next-gen European XR smart headset, all assisted by the latest advances in Artificial Intelligence (AI). It will then evaluate its result in five complementary and ambitious pilots in different industrial sectors including aerospace, home appliance, aluminium, electric distribution, and hybrid human-robot industries. For this purpose, our project will involve a complementary group of the best-in-class European experts and leading industries adopting a user-centric methodology coordinated by an SSH expert to ensure proper consideration of societal, ethical, and legal issues and ethical use of XR and AI technologies.

Keywords: portable 3d scanning,digital twin,generative ai,nlp,llm,xr authoring tools,xr collaboration platform,xr smart headset,xr training,xr assistance,aerospace,home appliances,manufacturing
Distributed and prepared. A new theory of citizens' public connection networks in the age of datafication (PREPARE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

In the last decade, societies across the world have been challenged by fragmenting public debate, fueled by algorithmically steered social media and new threats of propaganda and misinformation. The dual tendency of political apathy and polarization pose grave problems for a well-functioning democracy. As the social sciences appear unable to mitigate the challenges with a seemingly ignorant and passive citizenry, PREPARE proposes a radically new approach. PREPARE fills a research gap on the impact of algorithmic media and datafied everyday life on citizens? potential for political engagement. Current research on people's connection to the public is predominately interested in measuring the political knowledge of so-called "informed citizens", or studying the everyday micro-aspects of news media use. The leap proposed by PREPARE changes the focus from each citizen's "informedness" to develop and test a groundbreaking theory of distributed preparedness, building a cohesive theory for a fragmented field. PREPARE will stake out a new path for research on citizens? role in democracies. The project will develop a feasible, normative theory of citizens? orientations to the sphere of politics in datafied societies: their networks for public connection. PREPARE's research questions concern 1) how people stay prepared to engage with public issues, and 2) what resources they need to move from stand-by to engage. PREPARE substantiates the new theory through thickening of big data, with three ethnographies integrated with digital methods, of so-called disconnected citizens. The three groups are young urban immigrants, rural manual workers, and women outside the labour market. The path cleared by PREPARE allows research to constructively engage with improving democratic societies and civic awareness.

Keywords: media use,news consumption,public sphere,qualitative approach,democratic theory
From Gene to Cure (GCure)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Portugal
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2499998.69
EU funding (EUR): 2499998.69
Participants: 1
Project status: SIGNED

GCure aims at unlocking the Research & Innovation (R&I) potential of the University of Coimbra (UC) in Biomolecular Medicine. The actions involves establishing an ERA Chair dedicated to next-generation Gene Therapy Vectors, building upon UC's strong foundation in Gene Therapy research at the Center for Neuroscience and Cell Biology (CNC-UC). Gene Therapy, utilizing genetic material to treat or prevent diseases at their root cause, promises a significant shift in medical treatment paradigms, particularly for inherited diseases. With 24 approved gene therapies and ongoing developments, the field shows promise, yet faces challenges, notably in viral vector-based delivery systems. The specific objectives of GCure include creating a core R&I cluster on next-generation Gene Therapy Vectors, optimizing UC's viral vector production facility, establishing a training program on Gene Therapy knowledge & technology transfer, expanding UC's participation in collaborative R&I projects, and enhancing UC's international recognition in the field. To achieve these goals, renowned gene therapy pioneer R. Jude Samulski has been appointed as the GCure ERA Chair holder. Samulski's expertise and achievements in the field, including multiple FDA-approved gene therapies and numerous patents, ensure leadership in advancing UC's Gene Therapy initiatives. GCure also aims to attract international researchers to UC, fostering a sustainable research group and enhancing resources. Synergies between diverse research subjects will improve UC's research and innovation performance, attracting high-value collaborations and funding opportunities. In-house reforms in research management and open science strategies, coupled with a robust training program, will maximize GCure's contribution to the knowledge-based economy and society. GCure represents a strategic endeavor to propel UC to the forefront of Gene Therapy research and innovation, fostering significant advancements in healthcare and well-being.

Keywords: aav vectors,gene delivery vectors,bioengineering,manufacturing of gene therapy vectors,novel capsids
Next-gen technologies for enhanced metro operations (NEXUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Europe's Rail
Action type: Research and Innovation actions
Partnership: EU-RAIL (JU-JTI)
Countries involved: Italy,Austria,Bulgaria,Portugal,Greece,Belgium,United Kingdom
Call: FUTURE METRO SYSTEMS (HORIZON-JU-ER-2023-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 3624206.88
EU funding (EUR): 2997019.38
Participants: 13
Project status: SIGNED

In the evolution of urban transport, NEXUS seeks to establish an innovation benchmark, addressing crucial challenges and guiding European metros toward transformative futures. The collaborative effort unfolds through three interconnected workstreams, each contributing to overall progress. - WS1's core is the mission to redefine metro adaptability to demand fluctuations. Meticulous analysis and feasibility studies elevate adaptability, showcased through simulation tools. The focus remains on user-centered optimization aligned with evolving passenger needs. - WS2 focuses on train control systems of tomorrow. A comprehensive feasibility study paves the way for fully automated systems. Sustainability, safety, and seamless integration characterize the exploration, addressing challenges in infrastructure and system complexities. - WS3 delves into the innovative realms of AI and data science in metro transport. In collaboration with WS1 and WS2, this workstream explores promising AI applications. Rigorous evaluation ensures these digital innovations resonate practically in metro system implementations. Together, these workstreams harmonize in a holistic approach, envisioning a future where technology enhances operations responsibly and sustainably. NEXUS accentuates societal needs, weaving a narrative where metros become living, adaptable entities. Stakeholder involvement, including metro operators and passenger representatives, deepens the project's impact. Their participation resonates the results of NEXUS not only locally but also on the international level. Through optimization, analysis, energy and service efficiency, NEXUS aspires to pioneer innovative solutions for the urban and metro transport of the future, where the journey is as significant as the destination.

Keywords: metro,urban mobility,optimized capacity,simulation,metro systems,control systems,ai,cyber security,secure metro sustainable transport,cost effective
Unravelling the potential of the wheat microbiome for the development of healthier, more sustainable and resilient wheat-derived food & feed products (WHEATBIOME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Portugal,Spain,Poland,Netherlands,Lithuania,Hungary
Call: Microbiomes in food production systems (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5060547.91
EU funding (EUR): 5060547.25
Participants: 13
Project status: SIGNED

Current food production systems face many challenges (climate change, rampant demographic development) and new sustainable approaches are urgent. Wheat is a central crop in Europe and soil and plant microbial communities are of particular interest in wheat crops since (1) they are crucial solutions for restoring soils and protecting the crops and wheat-derived products against pathogens; (2) they play a key role in regulating plant metabolisms and, thus, the quality and properties of crops; and (3) they can be promising producers for a wide range of nutritional and healthy food and feed products. However, more studies on wheat microbiomes are needed as the current data is scarce. The WHEATBIOME project will contribute in the understanding of the role of the wheat microbiome on sustainable development by undertaking cutting-edge research with strong collaboration between academia, industry, food system actors and governmental authorities distributed along 6 EU countries, and will explore the role of microbiomes in wheat production systems in a broad approach from soil to plate to: • Understand the effect of biotic/abiotic factors on wheat microbiomes with 2 case studies and a lab-scale demonstrator. • Unravel the soil-plant microbiome cross-talking on wheat metabolism and nutritional quality, and deliver sustainable farming practices for resilient and nutritious wheat crops via a new decision support system (DSS). • Discover new fermentation capacities within indigenous wheat microbiomes and develop novel foods and feeds. • Study the role of microbial fermentations in food/feed quality and reduce food waste by recirculating wheat by-products. • Determine the interactions between wheat (prebiotics, probiotics, bioactive compounds, immunogenic proteins, etc.) and the human/animal microbiota, and its effect on human and animal health. • Assess the perception of food system actors and citizens about microbiomes within food systems.

Keywords: wheat,microbiomes,fermented drinks,microbiota,food systems
Overcoming Resistance to Anti-cancer Drugs by Blocking Mutation-prone DNA Polymerases and the SOS Response (ResistSOS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Background: A large fraction of cancer patients die because their tumors initially respond to drugs but later they evolve tolerance. Thus, resistance to diverse drugs, along with the soaring costs of new treatments, are emerging as major societal issues of the 2020s. Herein, we explore one of the most distressful examples, tolerance of lung cancer to EGFR-specific tyrosine kinase inhibitors (TKIs). Working hypothesis: In similarity to bacteria exposed to antibiotics, when cancer cells are exposed to TKIs they enlist SOS responses, which activate endogenous mutators. Hence, we will combine the relatively effective but mutagenic TKIs with drugs that disarm the mutators. This scheme will be applied on models of EGFR+ lung cancer, a disease that repeatedly evolves mutations and resistance, but eventually leaves millions of patients with no treatment choices. Specific aims: Our initial studies identified one triad of the SOS system: a sensor of cell death - GAS6, a mediator - AXL, GAS6’ receptor, and a mutator - low-fidelity DNA polymerases. Remarkably, blocking AXL using an antibody irreversibly prevented relapses when combined with EGFR inhibitors. Along with establishing this triad, we will employ transcriptomics, protetomics and metabolomics to resolve parallel mutators and sensors. Likewise, we will explore alternative ways to block resistance, for example by directly targeting DNA polymerases, MYC and purine metabolism. Aiming at strategies that minimize SOS enlisting, we will explore the premise of boosting immune destruction of cancer cells. Significance: According to the current status quo, next-generation inhibitors are being applied when resistance emerges. However, this scheme does not cure, only buys time. ResistSOS offers an alternative that might eradicate resistance and cure disease models following treatments that are based on deep understanding and blocking the mutagenic SOS response.

Keywords: lung cancer kinase inhibitors resistance to drugs mutations monoclonal antibodies cancer therapy resistance to antibiotics sos response
Breakthrough Regulatory Innovation and Development throuGh sandbox Environments (BRIDGE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Belgium,Germany,Netherlands,United States,Switzerland,France,United Kingdom,Israel,Denmark,Spain,Finland,Ireland
Call: Modelling regulatory sandbox mechanisms and enabling their deployment to support breakthrough innovation (HORIZON-JU-IHI-2024-08-two-stage, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 9355434.25
EU funding (EUR): 5199814.25
Participants: 41
Project status: SIGNED

BRIDGE aims to enhance healthcare innovation in Europe by developing a comprehensive framework for designing and operationalizing regulatory sandboxes. By addressing current regulatory limitations and engaging all stakeholders while ensuring compliance, the project seeks to create adaptable, fit-for-purpose methodologies that strengthen the regulatory ecosystem's capacity to promote healthcare innovation. The project’s objectives include identifying and analysing existing regulatory sandboxes across various domains and maturity levels, to determine how their modules can complement current healthcare regulations. BRIDGE will develop a horizon scanning methodology to continuously identify emerging technologies that challenge existing regulatory systems, analyzing their requirements for potential inclusion in regulatory sandboxes to ensure adaptability within an evolving innovation ecosystem. Through multi-stakeholder consultations, BRIDGE will elaborate and assess case studies, as well as develop operational checklists for module design and evidence packages to guide tailored sandbox launches. The project will also develop the Modular Operational Sandbox for Healthcare Innovation and Compliance (MOSAIC), an architectural model with interconnected modules featuring detailed functional specifications and mapped information flows aligned with specific case studies. Additionally, BRIDGE will engage key stakeholders—including regulatory bodies, industry consortia, HTA bodies, payers, healthcare providers, and patients—in an in-depth analysis, consultation, and consensus-building process to ensure the sandbox approach is comprehensive, functional, and adaptable to future advancements. Finally, the project will deliver comprehensive recommendations for the sandbox methodology’s end-to-end operations, encompassing legal, compliance, policy, and regulatory outputs to provide a robust implementation framework.

Keywords: regulatory sandboxes sandbox recommendations sandbox case studies