Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Establishing services enhancing the innovation management capacity of SME’s in the Enterprise Europe Network (CIPRAASME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: France,France
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-06-01
End date: 2014-12-31
Duration (months): 7.0
Total project cost (EUR): 103430.0
EU funding (EUR): 82744.0
Participants: 5
Project status: CLOSED

The scope of this proposal is to develop and implement new services in enhancing innovation management capacity of SMEs and Key Account Management services for beneficiaries of SME Instruments in Rhône-Alpes Auvergne France.

Keywords: enhance innovation management capacity,key account manager for sme instrument beneficiaries
PETRA - Photonic Environment moniToring Risk Assessment (PETRA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-02-01
End date: 2016-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The goal of PETRA (Photonic Environment moniToring & Risk Assessment) is the design and the IPR transfer of a radically new precommercial photonics based prototype for noninvasive continuous remote monitoring system for geo-technical risk assessment. PETRA will step from the ERC-funded project PHODIR that successfully carried out the realization and the field trial of the first photonic based radar prototype, and from the contacts that were made between CNIT and industrial partners during the PoC PREPaRE, that focused on the preindustrial design and IPR selling of an optics based radar for integrated traffic control in airports. The specific application on which PETRA will focus is the high precision real time analysis and mapping of potential risk areas for health protection, disaster prevention and for new civil engineering buildings (as bridges or power plants) where the advances of photonics will be of practical interest in a short-medium term, and it will: i) study the technical requirements and the current limitations of earth monitoring systems, to define the technical specifications for a commercial photonics based integrated radar system; ii) accordingly modify the radar structure and the data processing tools defined during the PHODIR project, allowing a short/medium-term industrial realization and commercialization with an attractive cost/performance ratio; iii) boost the IP transfer of each single subsystem preindustrial design to companies either through already filed patent selling or by encouraging companies to patent the presented design.

Keywords: environment monitoring,radar,microwave photonics
New super-energy efficient non-volatile memory manufacturing – bringing Europe back on the semiconductor track (LAST CHANCE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project will map out the global market and technical specifications for new non-volatile static random-access memory products (nvSRAM) and systems (system on chip, embedded systems) in a feasibility study, including a business plan for the market introduction. ANV, as a fabless company, will prepare an innovative SONOS-module with 90nm-technology for SOC solutions with extremely low power nv memory cells. This is a ground-breaking solution, merging the advanced but dissimilar technologies ‘Logic’, ‘DRAM’, and ‘FLASH’ in one cost-effective solution. The nvSRAM IP blocks offer unlimited and fast (< 20ns access) read and write operation and a reduced energy demand by factor 10,000 compared to a conventional Flash. No comparable solutions on the market provide such scalable high energy efficiencies, application areas and cost saving opportunities. This will enable the target users to integrate low power nv memory into SOC and dedicated stand-alone solutions at competitive prices. Industrial electronics, medical technology products, measuring/sensor technology and data storage/server technology (computing) are the core markets with a fast growing volume of about $150Mn for nvSRAM products and estimated $15.7 Bn for embedded FLASH. The micro-electronics industry in Europe, comprising research-intensive SME, fabless and producing companies receive competitive SOC solutions for new product innovation in order to step back on the road to success in the semiconductor world. The feasibility study will assess and prioritize technical specifications for process integration at the production line according to customer needs as well as tasks for production robustness of the new NVSM. It will prove the economic viability focusing on market trends and development of a licensing and IP strategy and elaborate a business plan including pilot products, ROI, risk assessment and financing model.

Keywords: non volatile semiconductor memory,nvsm,nvsram,systems on chip,sonos,logic,dram,flash,cmos,low power nv memory
Making AML treatment a clinical reality: A novel anti-IL7 receptor antibody to deliver Lap to 5LO positive cells (LapIt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Acute Myeloid Leukemia (AML), a cancer of the myeloid line of blood cells, is the most common type of leukemia in adults (~350.000 new cases yearly worldwide), yet continues to have the lowest overall survival rate of all leukemias (26.9%). The disease is characterized by clonal expansion of undifferentiated myeloid precursors, leading to anomalous hematopoiesis and bone marrow failure. Current AML management still relies largely on intensive chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT) with treatment costs up to €300k per patient. Although some AML patients respond to chemotherapy and HSCT, most patients that go into remission show disease relapse (up to and 70%). In addition, minimal advances have been made for patients unable to tolerate intensive treatment, mostly representing older patients. This presses the need for new AML treatments that are (1) more effective and (2) tolerated by all patients. In LapIt, we will further develop a novel treatment strategy for AML, based on targeting a macromolecular target that is marker of poor prognosis for AML patients with the drug Lap. Importantly, to guarantee specific uptake of Lap by AML cells and minimize side effects to healthy cells, the drug will be further developed as an antibody-drug conjugate targeting a validated receptor which is overexpressed in AML and other leukemias. As such, our drug will not only be more effective than currently used AML therapies, but will also be tolerated by patients unable to tolerate intensive treatments. With our proposed drug candidate we are able to make, for the first time, AML treatment a clinical reality for any AML patient.

Keywords: leukemia,therapy,antibody drug conjugate,natural products
A new method for theoretical spectroscopy of strongly correlated materials - dynamical configuration interaction (DCI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

As researchers continue to search for new technological materials, they are increasingly exploring the regime of strongly correlated molecules and solids. Strongly correlated materials are those with strongly interacting electrons that cannot be accurately described by simple mean-field methods in physics. Theoretical spectroscopy for strongly correlated materials gives the ability to predict their excited states important for applications - their spectra - by numerical calculations instead of synthesizing and measuring them in the laboratory. However, accurate theoretical spectroscopy for strongly correlated systems is a considerable theoretical challenge. We present a new quantum embedding theory for strong correlation that embeds quantum chemistry inside of many-body perturbation theory (MBPT). In our theory, strongly correlated electrons are treated with configuration interaction (CI) using the exact ab-initio Hamiltonian. Weakly correlated states are treated with less expensive approximations in many-body perturbation theory (GW/BSE). The coupling between the two spaces gives a dynamical correction to the normal CI Hamiltonian, a method that we call dynamical configuration interaction (DCI). The method naturally includes non-local correlation, is systematically improvable by expanding the CI basis, and eliminates the need for frequency dependent quantities common in Green's function embedding. Our goal is to develop an efficient, scalable implementation of DCI and benchmark it against other methods in many-body physics and quantum chemistry. Eventually, we will apply our DCI implementation to porphyrin and phthalocyanine molecules. These molecules host strongly correlated d-electrons at their center and are heavily researched for their potential technological applications. DCI could give a new level of predictive accuracy to the theoretical spectroscopy of strongly correlated systems and unlock their potential for new optoelectronic applications.

Keywords: many body perturbation theory,strongly correlated electrons,green s function,electronic structure theory,wave function,bethe salpeter equation,theoretical spectroscopy
All-in-1 “buffing & dedusting” machine for rubber industry (One4Clean)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Rubber is an easy-to-process material whose cost effectiveness makes it a most favoured product in several industries, as demonstrated by its global market expected to reach €30 billion by 2022 at a 4.6% CAGR. In order to satisfy the demand, suppliers and manufacturers of raw rubber sheets are continuously optimizing their processes, especially the finishing steps as clean rubber is critical to improve the quality of finished products. The quality of the raw rubber sheet is highly dependent on eliminating imperfections and dust removal from the upstream processes. Traditional cleaning in the rubber industry is carried out through independent buffing and dedusting machines which affect negatively product output rate, consume high energy, provide only average cleaning efficiency with multiple pass and dust emission causing environmental hazard. MCR, expert in machine development, maintenance and retrofit for the leather, textile and rubber fields, is addressing the market need by launching One4Clean “All-in-One” machine which combines the functionality of separate buffing and dedusting machines into a single compact, automated stand-alone system. Compared to traditional machines, our innovation will double the output rate and delivers 98% cleaning efficiency in a single pass, while reducing workers allocated to machine operations by 50%, energy consumption by 20%, and dust released to a minimum. One4Clean is an environmentally friendly machine which will help customers to become sustainable through resource savings, low energy use, better air quality and working conditions in the factories. This first-of-its-kind solution can clean rubber sheet, but also leather skin or textile fabrics and will cost 15% less than traditional machines. Our consolidated business plan indicates that we will sell 220 machine units after 5 years of exploitation, generating €17.2 million of accumulated revenues and creating 24 full-time positions in our company.

Keywords: rubber,rubber sheet,buffing,dedusting,finishing,dust removal,cleaning efficiency,productivity,leather,textile
Response of Earth system to extreme palaeoclimatic and palaeoenvironmental changes: A multiproxy study of the aftermath of the Toarcian hyperthermal (RECOVERY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-18
End date: 2023-01-17
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Climate change is currently one of the major challenges for our society. Observations from past time intervals marked by climatic and environmental instabilities are crucial to predict the consequences of current global warming and the feedback mechanisms that would allow the biosphere to return to steady-state conditions. The Toarcian Oceanic Anoxic Event (T-OAE, Early Jurassic) was one of the most extreme hyperthermal events in Earth history. It is well constrained that volcanic activity triggered the cascade of environmental feedbacks associated to this event, whereas the evolution in the middle–late Toarcian and the recovery phase are still poorly understood. With RECOVERY, I will fill this gap by giving a holistic appraisal of the palaeoclimatic and palaeoenvironmental evolution in the aftermath of the T-OAE and of the feedback mechanisms, which helped the biosphere to recover. RECOVERY will follow a multi-proxy approach combining sedimentological observations, and mineralogical and geochemical analysis to (i) provide a high-resolution carbon isotope stratigraphy and trace carbon cycle dynamics, (ii) reconstruct the palaeoenvironmental conditions and constrain the climate-carbon cycle feedback mechanisms, (iii) evaluate changes in nutrient level and primary productivity, (iv) track the causality link between volcanic activity and environmental changes, (v) constrain continental weathering rates and evaluate the potential impact on global climate. The originality and innovative aspects of RECOVERY builds at the intersection of advanced analytical tools and theoretical concepts to provide an unprecedented comprehensive understanding of the feedback mechanisms implied in Earth system recovery after extreme palaeoclimatic and palaeoenvironmental changes, taking the aftermath of the T-OAE as a case study. RECOVERY will hence provide a crucial backdrop to glimpse our future and the response of Earth system to current climate change.

Keywords: mineralogy,geochemistry,biogeochemical cycles,feedback mechanisms,toarcian
A first in category prescription regimen for ADHD combining stimulants with intelligent dosing and digital capabilities (OnDosis01)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-04-01
End date: 2019-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The goal of this project is to develop a therapy that allows for more effective management of attention-deficit hyperactivity disorder (ADHD). ADHD is a common, childhood onset, neurobehavioural disorder characterised by a combination of inattention, hyperactivity and impulsivity impairing multiple areas of life. Stimulants are the most widely used ADHD medications and are proven effective on ADHD symptoms, but classified as controlled substances they are associated with concerns about side effects and potential for abuse. In addition, they require careful dose titration at initiation and throughout the patients’ life. OnDosis aims to address these challenges by developing a novel “combination product”, prescribed as an ADHD treatment regime, that combines a technological platform with stimulant active compounds. This integrated solution will simplify dose titration, enable ease of swallowing, offer adherence support and self-monitoring checks. Importantly, OnDosis’ solution is a personalised device with the potential to reduce risk for medication abuse through tamper resistance and tamper evident features. The ultimate success of the project will depend on generation of clinical data which will support partnering and out-licensing. OnDosis plans to apply for SMEi Phase 2 grant to take the product through required clinical studies, and then go to market through a licensing agreement with a strong commercial partner. OnDosis has a strong network established with potential pharma partners and investors, and has already gained support from investors that offer strategic support to the company. The burden of ADHD is increasing and the unmet need is growing. This encourages OnDosis in the endeavour of a needs-driven research to address this widespread challenge. Market research with several stakeholders in healthcare have convinced OnDosis of the potential to bring significant impact to patients with ADHD through this novel technology.

Keywords: adhd,combination product,personalised medicine
Does excessive junk food consumption change the way the brain reward system processes intrinsic rewards? (REBOST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: CLOSED

The prevalence of obesity worldwide continues to increase dramatically: 39% of adults are now overweight or obese. Excessive consumption of highly palatable sugar and fat laden foods, often referred to as “junk foods”, plays a central role in the development of obesity, possibly by dysregulating the brain reward system. The REBOST project aims to investigate the neurological mechanisms by which excessive junk food consumption adversely affects the reward system. I hypothesise that excessive junk food consumption desensitises the reward system, which alters responses to different intrinsic rewards. This project is innovative in that it investigates the neuronal and behavioural alterations in sensitivity to rewards beyond conditioned food rewards, by also studying the responses towards a secondary intrinsic (sexual) reward. This will be achieved by using a unique behavioural design and advanced in vivo techniques (fibre photometry, dLight1 and chemogenetics). This protocol allows to simultaneously investigate real-time neuronal activation and behavioural effects during all distinct phases of reward: i) expectation, ii) approach and iii) consummatory behaviour. Another highlight of the project is the use of the Cafeteria Diet model (CAF). CAF mimics human behaviour more accurately than other models, by feeding rats a choice of the same unhealthy, but palatable products as humans. By integrating complementary expertise on CAF and food reward from the ER and on sexual behaviour and the advanced techniques from the host, the project will unravel the effects of CAF on the specific brain reward projections from the Prefrontal Cortex to the Ventral Tegmental Area. This will contribute to explain the underlying mechanisms of the development of obesity and the vulnerability of the brain reward system, which will open up new strategies for biomedical research and therapeutic applications, both for obesity and addiction.

Keywords: cafeteria diet,junk food,obesity,sexual behaviour,brain reward system,chemogenetics,fiber photometry,dlight1,female rats
Integrating Rural Migrants in Cities - A Field Experiment in Mozambique (QUELIMANE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: CLOSED

Sub-Saharan Africa is the world’s fastest-urbanizing region. The movement of people from the countryside to denser cities will likely create progress toward some of the Sustainable Development Goals in the medium term, especially SDGs 11 (Sustainable Cities and Communities), 13 (Climate Action), 8 (Decent Work and Economic Growth) and 5 (Gender Equality). However, rural-urban migration can also cause disruption and conflict in the short term. Furthermore, many autocratic national governments oppose urbanization because it increases the cost and difficulty of controlling citizens through patronage and intimidation. Therefore, the responsibility often falls on city-level governments in the developing world to peacefully integrate new migrants with existing residents, and there is an urgent need for evidence on how to do so. This project will help meet this need in the context of the Mozambican city of Quelimane (pop. 350,000). Quelimane has created a program for rural migrant integration that includes job matching, training and education, financial services, and tax incentives. The government of Quelimane has invited me and my supervisor at NovaSBE, Pedro Vicente, to conduct a randomized controlled trial (RCT) to rigorously measure the causal impact the program, by selecting randomly which blocks in the city will be eligible for the program first. To measure both the direct effect of the program and its externalities, we will survey 500 long-term residents in treatment and control blocks as well as 1000 recent migrants and their still-rural connections. We plan to study not just how the program affects livelihoods, but attitudes, prejudices, political attribution, and further migration. Understanding how Quelimane can improve the urban integration of rural – and which parties have political incentives to do so – can help other local governments in Africa build institutions to meet similar challenges, a key objective of SDG 16 (Peace, Justice and Strong Institutions).

Keywords: development,urbanization,gender,climate change,local government,randomization,africa,mozambique,public administration