Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BioHybrid Optoelectronic Materials (BiHyOMat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-06-20
Duration (months): 24.0
Total project cost (EUR): 191325.6
EU funding (EUR): 191325.6
Participants: 1
Project status: CLOSED

BiHyOMat is an ambitious research project at the interface of chemistry, physics and biology, with the aim to produce high-end optoelectronic materials. To this end, the project will take advantage of the co-crystallization of toroidal proteins and photosensitizers into monodimensional self-assemblies by means of electrostatic interactions, being a field where the hosting group is playing a pioneer role. By means of pH, temperature and electrolyte control, different proteins and dyes will be conjugated to a wide variety of materials with different stabilities and optical properties. Peroxiredoxin, an ubiquitous protein with a wide selection of isoelectric points has been selected as protein scaffold of the columnar stacks, along with a selection of charged phthalocyanines and porphyrins playing a dual role as molecular glue and photoactive moieties. The latter group will be obtained through collaborations, commercial sources or synthesized by the candidate.The resulting materials will be thoroughly characterized by a broad selection of techniques, including cryo-TEM, SAXS and time-resolved spectroscopy. Additionally, the spectroscopic properties arising from the anisotropic array of dyes into this well-defined structure will be thoroughly explored. Furthermore, the resulting tubular arrays will be conjugated supramolecularly with magnetic nanoparticles, endowing them with magnetoresponsive behaviour. Finally, the tubular aggregates, presenting a well-defined inner pore, will be employed as nanoreactors to synthesize finely tuned rod-like nanoparticles, taking advantage of the hollow structure of the stacks.

Keywords: biohybrid materials
The First In Vitro Diagnostic Device for the Early Detection of Cardiac Ischemia (AGLYC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-03-01
End date: 2022-06-30
Duration (months): 40.0
Total project cost (EUR): 2727139.0
EU funding (EUR): 1908997.3
Participants: 1
Project status: CLOSED

Cardiovascular diseases (CVD) are the leading cause of death/morbidity across the globe, accounting for 31% of all deaths in 2015. In the same year almost 49 m Europeans were living with CVD. Early detection of ischemia is essential to prevent the progression of heart damage and the irreversible tissue damage (necrosis) that can lead to heart failure. AGLYC is an IVD lab-based test for the early detection of ischemia (15 mins event onset) in the absence of the irreversible necrosis of the tissue. AGLYC demonstrates a 98% sensitivity in detecting the presence of ischemic heart disease. Our main competitive advantages are high sensitivity, early detection of ischemia, and cost effectiveness. The global in vitro diagnostics (IVD) market was valued at $64.02 bn in 2017 and is projected to reach $87.93 bn by 2023, at a CAGR of 5.2%. The laboratory diagnostic test (lab-based) market represents 86% of the total diagnostic testing market. Specifically, the market for lab tests related to acute cardiac ischemic events represented about $166 m in total sales in 2015. We have estimated a lab-based target market of >70 m patients. Our main business model will be a sublicense model based on the development of a laboratory-based test that we will develop and then sublicense to either a medical device company (MedTech) or to a pharmaceutical company. With this model and the successful completion of the SMEI phase 2 we estimate an EBITDA of around €23 m. The company closed a first funding round of €2.4 m on October 2017 to cover nearly 65% of the expenses of the development plan. GlyCardial Diagnostics, S.L. was founded in 2017 as a spin-off of the ICCC- IR-Hospital de la Santa Creu i Sant Pau and the Spanish National Research Council with the focus of developing a novel IVD test for cardiac ischemia. Our vision is to improve the early diagnosis of cardiac ischemic events, reducing the impact of the disease on patients’ lives and society as a whole.

Keywords: cardiovascular diseases,in vitro diagnostic device,cardiac ischemia,early detection
Artificial Intelligence based Smart Charging Assistant for Electric Light Commercial Vehicle Fleets (Konetik eLCV)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-01-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Light Commercial vehicle fleets are important for the EV adoption A LCV is a business tool, so the utilisation rate and ensuring business continuity are key. Integrating and managing electric LCV is challenging due to the limited driving range and charging infrastructure. In this project, our aim is to make a feasibility study of developing the first AI based charging assistant for Light Commercial Vehicle fleets. As part of the project aim is to research into the technical feasibility of analyzing vehicle charging data from the electric LCVs and combine that with consumption data from public, home and office chargers to ensure business continuity of eLCV fleets and save money on charging and reducing idle time. According to the IEA, EV/HEVs stock is projected to reach 200 Million units by 2030. The total EV/HEV market is expected to grow up 233EUR bn by 2021 growing at a 40.65% The project will allow us to facilitate the market spread of eLCVs with the first machine learning based smart charging assistant tool based on our unique algorithm that combines advanced energy management and telematics. This will imply to disrupt into the European and international market by saving significant money on eLCV charging and reducing downtimes for our client while generating 5,1 M€ profit until 2022 and a generation of 42 new direct jobs on the company level for Konetik. Konetik is a telematics company focusing on products helping the widespread of electric vehicles. Konetik serves 300+ companies 3 energy utilities already engaged (NKM, ENGIE, EnBW) regarding a pilot program. Selected as one of the top 100 Berlin based startups
ChildRescue - Collective Awareness Platform for Missing Children Investigation and Rescue (ChildRescue)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Ireland,Cyprus,Belgium,Greece,Greece,Romania
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2020-12-31
Duration (months): 36.0
Total project cost (EUR): 2333837.5
EU funding (EUR): 1998812.5
Participants: 12
Project status: CLOSED

More than 250,000 cases of missing children are annually reported in the EU. Through an innovative approach on the missing children investigation cycle, ChildRescue will be instrumental in leveraging the collective awareness, resourcefulness and action for a humanitarian cause: to expedite more rapid and effective resolution of missing children cases. The project will also take special care for supporting the identification missing unaccompanied refugee minors, which is an emerging issue nowadays. ChildRescue will explore patterns of interaction and awareness during the missing children investigations, leveraging the untapped potential of open-social-linked data to augment the background information of missing children through multi-layer (personal, psychological, social and activity) profiling and predictive analytics, respecting and protecting privacy and personal data. ChildRescue will provide evidence-based insights for the network effect’s impact to the missing children response organizations and allow them make informed decisions for each case. Based on location-based mobile notifications that spread using an intelligent system, citizens close to points a missing child was last seen or where s/he is probable to be found become “social sensors” for the investigation, paying attention to people passing by, contributing and validating potential evidence. ChildRescue will deliver a modular, open source solution to be adopted by different voluntary organizations, according to their needs and the readiness of their systems. The project’s results will be piloted in (a) missing children cases by the partners who are responsible for the Amber Alert and 116 000 hotline in those countries; and (b) missing unaccompanied minors cases supported by the Hellenic Red Cross, in complementarity with existing models of operation. Missing Children Europe and Red Cross will ensure visibility of the results across all relevant response and volunteer organizations in Europe.

Keywords: collective intelligence,new models of real time community mobilization,missing persons cause,amber alert,unaccompanied minors,multi layer profiling,predictive analytics,privacy
Adaptive BREEDING for productive, sustainable and resilient FORESTs under climate change (B4EST)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Finland,Sweden,Finland,Norway,Finland,Finland,France,France,France,Netherlands,Portugal,United Kingdom,United Kingdom,United Kingdom
Call: Adaptive tree breeding strategies and tools for forest production systems resilient to climate change and natural disturbances (H2020-BB-2017-2, 2017)
Start date: 2018-05-01
End date: 2022-09-30
Duration (months): 53.0
Total project cost (EUR): 6478663.25
EU funding (EUR): 6000000.0
Participants: 24
Project status: CLOSED

The goal of B4EST is to increase forest survival, health, resilience and productivity under climate change and natural disturbances, while maintaining genetic diversity and key ecological functions, and fostering a competitive EU bio-based economy. B4EST will provide forest tree breeders, forest managers and owners, and policy makers with: 1) better scientific knowledge on adaptation profiles and sustainable productivity, and added value of raw materials in important European tree species for forestry, 2) new and flexible adaptive tree breeding strategies, 3) tree genotypes of highly adaptive and economical value, 4) decision-support tools for the choice and use of Forest Reproductive Material (FRM) while balancing production, resilience and genetic diversity, including case studies developed with industrial partners, 5) integrative performance models to guide FRM deployment at stand and landscape level, 6) economic analyses of risks/benefits/costs, and 6) policy recommendations. B4EST will capitalise on the resources developed by past and current EU projects to produce -together with tree breeders, forest managers and owners, and the industry- operational solutions to better adapt forests to climate change and reinforce the competitiveness of the EU forest-based sector. To cover the geographical, economic and societal needs of forestry in the EU, B4EST will work with 8 (six native, two non-native) conifers and broadleaves with advanced breeding programmes (Norway spruce, Scots pine, maritime pine, poplars, Douglas-fir, eucalypts) or that are case studies of pest-threatened forests (ash) or valuable non-wood products (stone pine). Our approach will result in a high degree of data and knowledge integration, involving multiple and new target traits and their trade-offs; genomic information; temporal and spatial assessments in a wide range of environments; stakeholder demands; and forest owner and manager risk perception and acceptability of new breeding strategies.

Keywords: breeding,sustainability,new genotypes,adaptation profiles,genomic selection,deployment,tools for end users,bioeconomy,forest management,biotic,abiotic risks,genetic resources,wood production
BIOdiversity, STAbility and sustainability in Spatial Ecological and social-ecological Systems (BIOSTASES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 2092644.0
EU funding (EUR): 2092644.0
Participants: 1
Project status: CLOSED

Biodiversity loss is one of the greatest environmental challenges of our time. There is mounting evidence that biodiversity increases the stability of ecosystem functions and services, suggesting that it may be critical to the sustainability of ecosystems and human societies in the face of environmental changes. Classical ecological theory, however, has focused on measures of stability that cannot explain and predict these stabilizing effects, especially in spatial systems. The goal of BIOSTASES is to develop a coherent body of new theory on the stability of ecosystems and coupled social–ecological systems and its relationships with biodiversity at multiple spatial scales that can better inform empirical research. BIOSTASES will reach this goal through four complementary objectives. First, it will propose a mathematical framework focused on temporal variability as an empirically relevant measure of stability, and use this framework to build robust early warning signals for critical transitions. Second, it will use dynamical metacommunity models to explore a wide range of novel questions related to ecosystem stability and diversity–stability relationships across scales. Third, it will study the stability of complex meta-ecosystems to provide new perspectives on the stability of food webs and on synergies and trade-offs between multiple ecosystem services across space. Fourth, it will develop novel theory to study the long-term dynamics and sustainability of coupled social–ecological systems. BIOSTASES proposes an ambitious innovative research programme that will provide new perspectives on the stability and sustainability of ecological and coupled social–ecological systems in the face of environmental changes. It will contribute to bridging the gaps between theoretical and empirical ecology and between ecology and social sciences, and to developing new approaches in biodiversity conservation, landscape management, and sustainable development.

Keywords: ecosystems,social ecological systems,stability,spatial ecology
SUSTAINABLE WEED MANAGEMENT IN AGRICULTURE WITH LASER-BASED AUTONOMOUS TOOLS (WeLASER)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Innovation actions
Countries involved: Italy,Germany,Germany,Spain,Belgium,Poland,France,Netherlands,Denmark
Call: Integrated health approaches and alternatives to pesticide use (H2020-SFS-2020-1, 2020)
Start date: 2020-10-01
End date: 2023-12-31
Duration (months): 39.0
Total project cost (EUR): 5470660.0
EU funding (EUR): 4999393.0
Participants: 10
Project status: SIGNED

A growing global population demands increasing food production, which requires increasing use of pesticides and fertilizers. About 130 million tons of herbicides per year are used in Europe alone that persist in the environment, destroy non-target plants and beneficial insects for the soil and produce health effects in animals and humans –cancer, birth defects and endocrine disruption. Moreover, existing herbicides become more and more ineffective due to the evolution and spread of herbicide-resistant weeds. Substitution of herbicides by mechanical automatic systems is under study, but mechanical solutions contribute to deteriorate the soil properties, harm beneficial soil organisms and provide poor results for in-row weeding. WeLASER solution focuses on non-chemical weed management based on applying lethal doses of energy on the weed meristems using a high-power laser source. An AI-vision system discriminates crops from weeds and detects the position of the weed meristems to point the laser on them using a laser scanner. An autonomous vehicle carries these systems all over the field. A smart controller coordinates these systems and uses IoT and cloud computing techniques to manage agricultural knowledge. This technology will provide a clean solution to the weeding problem and will help to decrease significantly the chemicals on the environment. The required technologies for building this system and the number of actors needed to push it close to market demands the participation of ten experienced groups not easily found at the national level. Moreover, the cost of this high-technological equipment exceeds the funding levels of national organizations and claims the collaboration of large governmental institutions. Thus, with the EC help, WeLASER will put to work a large group of actors and stakeholders to advance in achieving the demanded productivity in agriculture while making the environment more sustainable and enhancing health to animals and humans.

Keywords: precision agriculture,laser equipment
Targeting RAS driven tumour immune evasion (RASImmune)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Mutations in RAS oncogenes are responsible for driving some 20% of all human malignancies, occurring in many major killers, such as lung, pancreatic, and colon cancers, but attempts to develop therapeutic interventions for RAS mutant cancers have yet to provide clinical benefit. By inhibiting pathways downstream of RAS along with other key signaling nodes, we have developed combination therapies that cause major regression of KRAS mutant lung cancer in mouse models. However, a major limitation is that the tumours are not eradicated and rapidly recur once treatment is withdrawn. Lung cancer is partly responsive to immunotherapies in the clinic, suggesting dependence on immune evasive signaling. We would like to understand whether RAS driven oncogenic signaling pathways act to protect tumours from the immune system. If so, what mechanisms does RAS use to evade tumour immune destruction and can these be specifically targeted to unleash the immune system on the tumour? Could we develop effective therapies rationally combining these with our existing RAS pathway therapies to achieve complete tumour eradication? We will use clinical samples to establish whether activation of RAS signaling pathways correlates with the ability of lung tumours to evade the immune system and by what mechanisms. We will develop appropriate preclinical models to test the impact of targeting immune evasion in RAS driven lung cancer, recognising the major limitations of existing mouse models for this purpose. We will also utilize these immunogenic preclinical models to seek novel mechanisms of tumour immune evasion, including through the use of in vivo functional genomic screens. Finally, we will establish how our existing optimal strategies for achieving RAS signaling pathway inhibition in lung cancer impact on the tumour immune microenvironment and establish strategies for combining these with interventions to subvert immune evasion, thus enabling optimal immune-assisted tumour destruction.

Keywords: lung cancer,targeted therapy,immunotherapy
Future growth in sustainable, resilient and climate friendly organic and conventional European aquaculture (FutureEUAqua)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Unlocking the potential of aquatic living resources
Action type: Innovation actions
Countries involved: Italy,Italy,Italy,Israel,Italy,Italy,Italy,Italy,Germany,Sweden,Greece,Greece,Sweden,Norway,Norway,Greece,Greece,Hungary,Greece,Greece,Norway,France,Netherlands,Denmark,Denmark,Denmark
Call: Sustainable European aquaculture 4.0: nutrition and breeding (H2020-BG-2018-1, 2018)
Start date: 2018-11-01
End date: 2023-04-30
Duration (months): 54.0
Total project cost (EUR): 7088073.25
EU funding (EUR): 6000000.0
Participants: 35
Project status: SIGNED

The overall objective of FutureEUAqua is to effectively promote sustainable growth of resilient to climate changes, environmental friendly organic and conventional aquaculture of major fish species and low trophic level organisms in Europe, to meet future challenges with respect to the growing consumer demand for high quality, nutritious and responsibly produced food. To this end, FutureEUAqua will promote innovations in the whole value chain, including genetic selection, ingredients and feeds, non-invasive monitoring technologies, innovative fish products and packaging methods, optimal production systems such as IMTA and RAS, taking into account socioeconomic considerations by the participation of a wide spectrum of stakeholders, training and dissemination activities. To achieve the objective and to relate to the work program, nine work-packages will contribute to improvements of future aquaculture. To ensure sustainable and resilient production of fish in the future we will work with tailor made fish and feed (WP1 and WP2), and validate fish performance and water quality in cost-effective production systems (WP4). Consumer demand and awareness of how to choose sustainable and climate friendly seafood is part of WP3. With the increasing production of seafood, we face space-conflicts, which, in combination with the current regulatory frameworks will be considered (WP3). Wireless sensor technology (WP5) for health and welfare monitoring and novel technology for product quality and packaging (WP6) to meet future demands, will be implemented. Stakeholders' knowledge and views will be important, and communication, dissemination (WP8) as well as training sessions (WP7) will be emphasized

Keywords: sustainable,resilient,organic and conventional,innovations,breeding,feeding,socioeconomy,market,production systems,welfare and health,product quality,packaging,training