Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unveiling the Molecular Secrets of Reproductive Mood Disorders: a Multi-Omics Approach Project (MoodMAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 1499999.0
Participants: 1
Project status: SIGNED

Reproductive mood disorders (RMDs), including premenstrual disorder and postpartum depression, have a significant impact on women and their families, contributing to the well-known gender gap in mental health. However, effectively diagnosing and treating RMDs remains an ongoing challenge. These conditions are closely tied to hormonal changes during menstruation and childbirth, indicating a shared vulnerability. While the precise mechanisms are not yet fully understood, emerging data, including my work, supports the hypothesis that genetic predisposition, chronic inflammation, and metabolic dysfunction play pivotal roles in the development of RMDs. The MoodMAP project aims to discover novel molecular markers for RMDs, provide insights into the biological factors influencing varying vulnerabilities to mood disorders in women, and enhance diagnostic, preventative, and treatment strategies for RMDs. The endeavor leverages three Nordic population-based cohorts a) to DEPICT a comprehensive architecture of RMDs by integrating genomic, inflammatory proteomic, and metabolomic data; b) to TRIANGULATE evidence for identifying biologically functional and causal biomarkers using cell data manipulated with hormones and advanced epidemiologic methods; c) and to PREDICT treatment outcomes, including treatment resistance and subsequent suicidal behavior, through multi-omics data and machine-learning methods. MoodMAP adopts an innovative approach by studying both RMDs together, aiming to uncover the biological basis of female vulnerability to mood disorders through multi-omics data. By integrating advanced omics techniques, hormone-manipulated cell data, and cutting-edge epidemiologic and statistical methods, MoodMAP holds the potential to understand the psychiatric sensitivity associated with sex hormones, drive transformative changes of diagnosis, prevention, and treatment strategies for RMDs, and ultimately contribute to the reduction of the gender gap in mental health.

Keywords: premenstrual disorders postpartum depression women s mental health reproductive mood disorders psychiatric epidemiology
BOosting the knowledge of the Strong interaction from quarkONium : an advanced simulation framework and beyond (BOSON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1499129.0
EU funding (EUR): 1499129.0
Participants: 1
Project status: SIGNED

Quarkonium, the bound state of a heavy quark pair, is central to many aspects of particle and nuclear physics. Like the hydrogen atom in quantum mechanics, the discovery of the first quarkonium J/psi was the first tangible observation that quarks are physical particles. It provided the first direct evidence of the strong interaction theory in the subatomic world -- quantum chromodynamics (QCD). It is nowadays also understood that quarkonium analogues are important in the new physics search programme at the Large Hadron Collider (LHC) at CERN and in the worldwide dark matter hunt. Quarkonium is also a powerful probe to conduct rich physics studies. Consequently, quarkonium has been measured by almost all experiments. Despite its importance, the quarkonium production mechanism in QCD remains to be understood, which places the theoretical interpretations of quarkonium data on shaky ground. The necessary ingredient to resolve the issues is to radically improve the quality and the precision of theoretical predictions. The primary goals of BOSON are to advance quarkonium studies with three objectives: 1. Pinning down the quarkonium production mechanism; 2. Advancing the precision of theoretical predictions; 3. Extracting maximal physics information from quarkonium data. To achieve them, BOSON will follow three routes: 1) the creation of an automated tool at next-to-leading order for any process involving quarkonia and elementary point particles with interfacing to general-purpose Monte Carlo event generators; 2) next-to-next-to-leading order cross section calculations for inclusive quarkonium processes; 3) phenomenological applications to particle, nuclear, and heavy-ion physics. BOSON outlines a challenging but feasible programme to advance our knowledge of the field, with positive impacts not only on the LHC community, but also on physicists working with facilities like RHIC at BNL, Belle2 at KEK, SPS at CERN and future high-energy experiments (e.g. EIC and FCC).
Magmatic Triggering of Cenozoic Climate Changes (MATRICs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1999968.75
EU funding (EUR): 1999968.75
Participants: 1
Project status: SIGNED

By preventing all the Earth’s carbon to be released into the oceans and atmosphere or to be stored within rocks, the geological carbon cycle acts as a global long term thermostat, linking the evolution of climate and life to plate tectonics. The uncertainty regarding CO2 emissions from continental magmatic arcs, a primary natural input of carbon into the ocean and atmosphere, is currently the greatest limitation to our quantitative understanding of the geological carbon cycle. The high-gain target of MATRICs is to reconstruct the time history of magmatic CO2 emissions from the Neo-Tethyan convergent plate margin and its critical contribution to early Cenozoic climate changes. This ambitious goal will be achieved by iterative geologic data acquisition and state-of-the-art numerical modeling. I propose to couple three established techniques to assess temporal changes in the source and amount of CO2 emissions from the Neo-Tethyan magmatic arc and assess their effects on early Cenozoic climate: (1) studies of melt inclusions, pockets of melts preserved within magmatic rocks, (2) analyses of trace elements concentrations (e.g., Hg, Te) within the sedimentary record, and (3) numerical petro-thermo-mechanical geodynamic and climate carbon cycle modeling. Undertaking this multi-disciplinary and ground-breaking project is now possible, owing to my success in using numerical modeling and diverse geological data to unravel the interactions between tectonics and climate accounting for magmatism. Engaging in a high-gain win-win challenge, MATRICs will either overturn or finally validate untested paradigms about the tectonic forcing of Cenozoic climate. In either case, the knowledge produced about the geological carbon cycle will allow us to better assess the drivers of natural climate variability and, by comparison, the climatic consequences of current anthropic emissions.

Keywords: geological carbon cycle,neo tethyan plate margin,continental collision subduction,data modeling approach
SPatial Analysis of Cancer Evolution in the Tumour Immune MicroEnvironment (SPACETIME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Netherlands,Sweden,Germany,Slovenia,Italy,Spain,Switzerland,Poland
Call: Addressing poorly-understood tumour-host interactions to enhance immune system-centred treatment and care interventions in childhood, adolescent, adult and elderly cancer patients. (HORIZON-MISS-2023-CANCER-01, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 11824365.25
EU funding (EUR): 11801347.0
Participants: 15
Project status: SIGNED

The introduction of immune checkpoint therapy for Non-Small Cell Lung Cancer (NSCLC) has improved clinical outcomes. However, due to primary or secondary resistance, only a minority of patients show long term responses, leading to exploration of a multiplicity of new agents and combinatorial strategies. Due to lack of biomarkers that can predict response, many patients are submitted to treatments that will not have clinical benefit. A thorough understanding of the biological processes causing resistance to immunotherapy in NSCLC could facilitate informed personalised therapy choices. This requires a multifactorial assessment of the tumour microenvironment, a complex and dynamic milieu, encompassing the majority of tumour-host interactions. SPACETIME brings together interdisciplinary expertise to achieve a superior understanding of the spatial and temporal tumour-host co-evolution, and drive translation into predictive biomarkers for precision immunotherapy. We will integrate spatial proteomics, transcriptomics, metabolomics and glycomics to analyse patient biopsies from early stage to metastatic disease, complemented with tissues from representative mouse models to cover the developments early after tumour initiation. Environmental and systemic factors that may influence this co-evolutionary process will be included to identify potential risk factors for therapy resistance. Ex-vivo, in vitro and in vivo assays will bring functional understanding of immune resistance mechanisms and identify key cellular interactions and therapeutic targets. This will be brought together by advanced computational approaches, to define spatial signatures, that will lead to a limited panel of potential prognostic and/or predictive markers for immunotherapy. Supported by engagement of key stakeholders, SPACETIME will pave the way towards development of a spatial signature test for patient stratification, to sidestep immunotherapy resistance and improve survival for NSCLC patients.This action is part of the Cancer Mission cluster of projects on “Understanding (tumour-host interactions)”.

Keywords: nsclc,immunotherapy,spatial analyses,multi factorial,computation
THE STRONG-AYA INITIATIVE: IMPROVING THE FUTURE OF YOUNG ADULTS WITH CANCER (STRONG-AYA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Netherlands,Romania,France,Poland,United Kingdom,Italy,Belgium
Call: Data-driven decision-support tools for better health care delivery and policy-making with a focus on cancer (HORIZON-HLTH-2021-CARE-05, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 7292902.5
EU funding (EUR): 7235023.0
Participants: 15
Project status: SIGNED

STRONG-AYA is a new, interdisciplinary, multi-stakeholder European network to improve healthcare services, research and outcomes for Adolescents and Young Adults (AYA) with cancer, defined as individuals aged 15-39 years at cancer diagnosis. AYAs with cancer form a unique group; they face age-specific issues (e.g. infertility, unemployment, financial problems) and decreased quality of life due to cancer and its treatment. Unlike dedicated healthcare and trials for pediatric cancer patients, AYA-specific healthcare services are scarce and vary across Europe. AYAs who are at the core of society and economy need access to age-adjusted and high-quality healthcare. AYA-care and research will benefit from collection and pooling of patient-centered data and collaboration among all stakeholders: patients, healthcare professionals, scientists, and policymakers. Our consortium of clinical and scientific leaders in AYA-care, data science and registries, European Cancer Organisation, Youth Cancer Europe and EORTC will build on previous initiatives and EU grants. Within STRONG-AYA we will set up a value-based healthcare research ecosystem to develop data-driven, interactive policy and visualization tools that bring, in co-creation with all stakeholders including patients, novel insights into AYA healthcare. The project objectives, include: 1) Development of a Core Outcome Set (COS) for AYAs with cancer; 2) Implementation of the COS in 5 national healthcare systems (FR, IT, NL, UK, PL) and establish national infrastructures for outcome data management and clinical decision-making and a pan-European ecosystem that also welcomes future European countries; 3) Disseminate outcomes and facilitate interactions between national and pan-European stakeholders to develop data-driven analysis tools to process and present relevant outcomes, establish feedback loops for AYA cancer patients and the healthcare systems, and improve the reporting and assessment of outputs towards policy-makers.

Keywords: adolescents and young adults with cancer core outcome set value based healthcare policy patient empowerment benchmarking distributed learning implementation real world data decision making
Understanding the biophysical embryo-uterine interactions during implantation (Mechanoimplantation)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

The proposed research aims to understand biophysical embryo-uterine interactions during peri-implantation to identify factors that guide processes such as embryo orientation, egg cylinder morphogenesis, and embryonic axis formation. Recent studies on implantation have gone beyond the traditional biochemical approach to reveal that mechanical interactions at the embryo-uterine interface are abundant and indispensable for proper implantation and development. Due to difficulties in recreating embryo implantation ex-vivo setups and lack of in-utero accessibility, the physical forces and mechano-chemical feedbacks involved in embryo implantation, however, still remain unknown. In this proposal, I will study how mechanical interactions at the embryo-uterine interface during implantation affect embryo development by directly measuring physical force at the interface, identifying the role of major mechanotransducer pathways, and making in-utero observations. In Objective 1, I will build an experimental setup with 2D polyacrylamide (PAA) gels of varying mechanical properties to recapitulate the characteristics of the uterine surface in ex-vivo setups and observe how embryo development depends on the mechanical properties of the substrate. In Objective 2, I will combine traction force microscopy (TFM) and live imaging to quantify how physical forces affect molecular and cellular events during the mouse implantation process. In Objective 3, I will identify how the mechanical forces are transduced into biochemical cues through live-imaging and genetic/pharmaceutical perturbations. Finally, I will investigate the implantation process live in-utero using multiphoton intravital imaging to validate my findings from ex-vivo studies. I hypothesize that mechanical cues will be spatiotemporally linked with biochemical signaling to significantly affect embryo development.

Keywords: traction force microscopy tfm,mechanotransduction,morphogenesis
Unveiling the nature of superconductivity in moiré quantum matter (mKoire)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2802250.0
EU funding (EUR): 2802250.0
Participants: 1
Project status: SIGNED

Graphene moiré materials constitute a new paradigm in condensed matter physics for the study of superconductivity and other collective electronic phases given their chemical and structural simplicity as well as large tunability as compared to other many-body systems. However, a comprehensive picture of the fundamental properties of superconductivity in graphene moiré materials is still missing due to the limited information attained so far at the microscopic level. Therefore, the need for local probe techniques that enable the exploration of superconductivity in moiré matter with outstanding energy and spatial resolution is pressing, and constitutes the main motivation of this project. The ultimate objective of this project is to unveil the microscopic mechanisms driving superconductivity in graphene moiré materials. To this end, I propose the local characterization of the superconductivity in various twisted graphene systems with unprecedented resolution (few µeV) by means of STM/STS measurements at milikelvin temperatures. Here I aim to unveil (i) the symmetry of the order parameter(s) in unambiguous connection with the valley, orbital and spin degrees of freedom, (ii) the origin(s) of the attractive interactions governing Cooper pairing, and (iii) the nature of the neighboring correlated phases as well as their interplay with the superconducting state. The intellectual merit of this project lies in the fact that will provide ground-breaking insights to long-standing questions in condensed matter physics, initially posed in complex unconventional superconductors, here instead tackled using simple, highly tunable moiré materials. Furthermore, this project has the potential to unveil forms of superconductivity never seen in nature before by using state-of-the-art microscopy technology that combines atomic-scale spatial resolution with the finest energy resolution.

Keywords: graphene superconductivity,moir,stm,flat band,electronic phase diagram
Fascist Prehistory: Nationalist and Internationalist dimensions of the human origin researches in the fascist capital (1925-1942) (FascistPrehistory)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-15
End date: 2027-03-14
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: SIGNED

FascistPrehistory proposes to study the development of palaeolithic archaeology as a field of inquiry in fascist Italy. Breaking away from the traditional historiographic association of archaeology with nationalism, the project seeks to open an international perspective on the conditions that shaped scientific development of the Homo sapiens paradigm under fascism. Considering the Vatican crucial role as a vector of the internationalization of the fascist project, FascistPrehistory scrutinizes the co-construction of the universalist paradigm of Homo sapiens in the contexts of fascist Rome during the 1920s through 40s. It sets its focus on interwar Rome as both the national centre and international display case of Italian culture under the fascist regime. It explores the developments leading up to, and in between, two major shows of palaeolithic archaeology – at the Vatican Missionary Exhibition (1925) and the Esposizione Universale di Roma (1942), respectively. The project concentrates on the role archaeologists played in the construction of the fascist international cultural agenda through their elaboration of universalists scientific discourses. Bringing together leading experts in the fields of scientific internationalism (Maastricht University) and Catholic and contemporary history (secondment, École française de Rome), FascistPrehistory aims to renew our understanding of the role of the sciences in the building of a cosmopolitan culture under fascism. By means of the placement at Istituto Italiano di Paleontologia Umana, the project will also provide an accessible introduction to fascist scientific heritage to various audiences.

Keywords: fascism,history of palaeoanthropology,museum studies,vatican