Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Breakthrough Biomedical Sensor for the Continuous Real-Time Detection of Ischemia, a Contributor in over 10 million Annual Deaths Globally (IscAlert)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-01-01
End date: 2023-10-31
Duration (months): 34.0
Total project cost (EUR): 2797875.0
EU funding (EUR): 1958512.5
Participants: 1
Project status: SIGNED

Sensocure is an ambitious Norwegian company, established in 2011, to commercialise IscAlert, the World's first implantable micro sensor for the early detection of ischemia. Ischemia is a restriction in blood supply to tissues, causing a shortage of oxygen, nutrients and inadequate removal of metabolic waste, eventually leading to cell death. Ischemia is suffered by 30m people globally every year, 10m of whom unfortunately lose their lives. Ischemia is highly preventable if it can be detected early. Unfortunately existing detection solutions simply cannot provide the early, accurate and real time monitoring required by surgeons and healthcare organisations. In contrast, IscAlert is a user friendly, fast, robust and cost effective real-time monitoring system. It conforms to current medical practice, improves patient outcomes and substantially reduced healthcare costs e.g. less corrective surgery and need for intensive care. We have made significant progress in the past 18 months. Following the completion of pre-clinical trials of the TRL6 sensor in 2018, Sensocure has now completed a TRL7 version of the IscAlert sensor. This design is smaller, cheaper and significantly more sensitive than the previous version. We now need to embark upon our next and final steps towards commercialisation; completing clinical trials, gaining Class II CE Marking medical device approval for sale in Europe and scaling up our production processes. Following the EIC Accelerator project, we will seek €3.5million in equity investment from the EC. This will allow us to scale operations and undertake FDA approval for sales in US markets. By 2027, we will employ an additional 113 staff, annual sales of 38,000 sensors, and have generated total accrued revenues of €59.92m and profits €16.95m. Market success will save lines and improve patient outcomes, delivering savings to healthcare providers of €102m p.a. and freeing up 18,300 hospital days.

Keywords: ischemia,replantation,reconstruction and plastic surgery,orthopaedic surgery,diagnostic devices,sensor detection,bio sensor,micro sensor,conductometric technology
Formal Frameworks for Modal Notions Conceived as Predicates (FOREMOTIONS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Philosophy strives for a better understanding of modal notions such as necessity, possibility, truth, knowledge. Modal logic, however, the formal tool privileged by philosophers to shape their theories about intensional notions, displays severe drawbacks: its use determines an incoherent treatment of different kinds of modalities and it is expressively weak as important general claims are not fully formalizable in it. In the project I develop an alternative approach to modal notions. Instead of treating them as operators applying to formulas, I will consider them as predicates applying to terms naming formulas. The overarching aim of the proposal is to provide philosophy with an expressive and coherent framework that could represent a valid alternative to modal logic. More precisely, I will develop three research objectives corresponding to three fundamental research gaps traceable in the current literature on modal predicates: the formulation of a natural account of the bearers of modal notions, a consistent and mathematically powerful treatment of the interaction of modal predicates, a predicate approach to de re modal ascriptions that will open the way for a new approach to modal metaphysics in the predicate setting. The project will develop a unified effort to bridge mathematical logic, philosophy of mathematics and metaphysics. It will result in the establishment of leading research profile setting the agenda for a network of researchers in the flourishing area of mathematical philosophy.

Keywords: logical and semantic paradoxes,meta mathematics,metaphysics,ontology
Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes (iHealth-T2D)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: India,Finland,Netherlands,United Kingdom,Sri Lanka,United Kingdom,Pakistan,United Kingdom
Call: Global Alliance for Chronic Diseases: prevention and treatment of type 2 diabetes (H2020-HCO-2014, 2014)
Start date: 2015-01-01
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 3614083.75
EU funding (EUR): 3614083.75
Participants: 12
Project status: CLOSED

South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden. We will complete a cluster-randomised clinical trial at 120 locations across India, Pakistan, Sri Lanka and the UK. We will compare family-based intensive lifestyle modification (22 health promotion sessions from a community health worker, active group, N=60 sites) vs usual care (1 session, control group, N=60 sites) for prevention of T2D, amongst 3,600 non-diabetic South Asian men and women with central obesity (waist≥100cm) and/or prediabetes (HbA1c≥6.0%). Participants will be followed annually for 3 years. The primary endpoint will be new-onset T2D (physician diagnosis on treatment or HbA1c≥6.0%, predicted N~734 over 3 years). Secondary endpoints will include waist and weight in the index case and family members. Our study has 80% power to identify a reduction in T2D risk with family-based intervention vs usual care of: 30% in South Asians with central obesity; 24% in South Asians with prediabetes; and 24% overall. Health economic evaluation will determine cost-effectiveness of family based lifestyle modification for prevention of T2D amongst South Asians with central obesity and / or prediabetes. The impact of gender and socio-economic factors on clinical utility and cost-effectiveness will be investigated. Our results will determine whether screening by waist circumference and/or HbA1c, coupled with intervention by family-based lifestyle modification, is an efficient, effective and equitable strategy for prevention of T2D in South Asians. Our findings will thereby provide a robust evidence base for scalable community-wide approaches to reverse the epidemic of T2D amongst the >1.5 billion South Asians worldwide.

Keywords: south asians,diabetes,obesity
Bioactive AdrenoMedullin is a Novel Outstanding Marker to Predict and Prevent Septic Shock (PreventSepticShock)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Germany
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 2137500.0
EU funding (EUR): 2137500.0
Participants: 1
Project status: CLOSED

Sepsis is a life-threatening condition that arises when the body's response to an infection damages its own tissues and organs. Although sepsis is initiated by infection, it is not the infection per se, which kills the patient, but rather the body’s response to it, in particular, the development of a shock, which is initiated by deterioration of the blood vessel system, hypotension, insufficient oxygenation of organs and finally their functional breakdown. For a clinician this situation occurs suddenly and there is no diagnostic tool to predict this event early enough to initiate adequate measures to guide the patient and prevent its death. Despite of large efforts and developments in the last decade septic shock is still the world biggest killer causing 5-6 million deaths a year worldwide. Thus the prediction of septic shock and stratification of high risk patients is still an unmet medical need. The novel bioreactive Adrenomedullin (bio-ADM) assay of Sphingotec is the first unprecedented analytical assay which stratified in a pilot study sepsis patients who have the risk to die from a septic shock with very high confidentiality. Thus adequate measures to restore blood pressure can be introduced in time and life can be saved. Feasibility studies elucidating all clinical and commercialisation aspects have given excellent prospects for bio-ADM. Thus, in the project the bio-ADM assay will be used in an observation study with 1000 ICU patients suffering from sepsis to validate the power of the novel biomarker and to indicate a cut-off for bio-ADM. Furthermore, the project is dedicated to conduct technical work to bring the marker to automation and point of care platforms of diagnostic partners to guarantee broad application after the project, and to carry out measures to disseminate and explore the project results to ensure quick penetration of an up to 500 million € diagnostic market. In this way the project will initiate dynamic and robust growth of the applicant.

Keywords: septic shock,bio adrenomedullin,biomarker
SiliconLaser (SiLAS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Switzerland,Netherlands,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3985418.75
EU funding (EUR): 3985417.5
Participants: 6
Project status: CLOSED

Our research aims to revolutionize the electronics industry by adding intra-chip and chip-to-chip communication at the speed of light, offering a significantly reduced energy consumption. Cubic crystal phase SiGe is known to be great for electronics. We propose to develop hexagonal crystal phase SiGe (Hex-SiGe) which features a direct bandgap and will add photonic capabilities to electronics. Direct bandgap silicon has been the holy grail of the semiconductor industry for many years, since it would allow integrating both electronic and optical functionalities on a silicon platform. Recent theoretical calculations predict that hexagonal crystal phase SixGe1-x features a tunable direct bandgap from 1380-1800 nm, exactly coinciding with the low loss window for optical fibre communications. We have recently developed a generic approach to grow defect-free hexagonal SixGe1-x with tunable composition. We propose to demonstrate efficient light emission from direct bandgap SiGe, followed by the development of a SiGe nanolaser. Work towards CMOS integration is included. The demonstration of a Hex-SiGe nanolaser will serve as a game-changer for transforming the electronics industry.

Keywords: direct bandgap silicon,hexagonal sige nanowires,nanolaser
Alzheimer Disease - gut connection (AD-gut)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,Belgium,Sweden,Belgium,Switzerland
Call: Biomaterials for treatment and prevention of Alzheimer's disease (H2020-NMP-2015-two-stage, 2015)
Start date: 2016-04-01
End date: 2020-03-31
Duration (months): 48.0
Total project cost (EUR): 7686620.0
EU funding (EUR): 5092886.25
Participants: 6
Project status: CLOSED

Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzheimer (GF-AD) mouse model and discovered a drastic reduction of cerebral Aβ amyloid pathology when compared to control AD mice with natural intestinal microbiota. In contrast, fecal transplantation of GF-AD with harvested microbiota from conventionally-raised AD mice dramatically increased cerebral Aβ pathology. Altogether, these results strongly support a microbial involvement in the development of AD and show how gut microbiome modulation can slow down or halt its onset. This paves the road to new indirect diagnostic and therapeutic approaches for AD prevention, based on gut microbiota modulation through probiotic cocktails. Based on these findings, the present proposal aims at designing and optimizing an efficient encapsulation strategy to guarantee the survival and the delivery of probiotic strains in the gut as opposed to standard strategies targeting directly the brain. A successful accomplishment of this goal will also allow to derive AD risk factors and to establish an objective baseline setting for AD diagnosis. Ultimately, the present project will open new horizons in biomedical diagnostics and personalized medicine through the marketing of these technologies and therapeutic concepts.

Keywords: probiotic cocktail encapsulation,gut microbiota,alzheimer s disease,diagnostic,prevention
The Dynamic Representational Nature of Working Memory Storage (DeepStore)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1926325.0
EU funding (EUR): 1926325.0
Participants: 1
Project status: SIGNED

Working memory excels in keeping ready the momentary contents of all of human higher cognition despite being strictly limited in storage capacity. How the brain accomplishes this feat, beyond the temporary maintenance of just experienced information, is hardly understood. An emerging view suggests that working memory storage is topographically distributed according to the information’s endogenous level of abstraction. However, very little is known about how such distributed storage is orchestrated spatiotemporally, that is, how representations at different levels of abstraction are structured dynamically in time to suit current demands. In DeepStore, we use tailored experimental designs and newly developed multivariate analysis techniques to explore for the first time directly the depth-dimension of working memory storage, in terms of dynamic levels of abstraction. Combining functional imaging, magneto-/electroencephalography, and invasive neural recordings will make it possible to track levels of abstraction spatiotemporally, with millisecond precision. In three ambitious experimental series, DeepStore will shed new light on long-standing open questions about working memory storage, including how it is modulated by attention, inattention, and distraction, and how multiple contents are stored simultaneously. The work will shape a new theory of the neurocognitive capacity limit in working memory. We will further test novel hypotheses about how working memory interfaces with long-term memory, and how it develops over the lifespan. Finally, we will combine our innovative human neuroimaging approach with direct electrophysiological recordings in non-human primates during the same task, to disclose the fine-grained neural mechanisms of dynamic abstraction down to the single-cell level. DeepStore is anticipated to provide fundamentally new insights into the dynamic and multi-layered nature of working memory, beyond the number and precision of items it can hold.

Keywords: cognitive neuroscience,working memory,memory,abstraction,aging,numerical cognition,mvpa,neural oscillations,fmri
Making Building Systems Simple (SUD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today, we spend more than 90% of our time inside a building (living, working, leisure), and the systems required to manage/control a building, are inefficient, expensive, and decentralised. Efficient building management is becoming not only more important, but also a more complex challenge as buildings standards increase with added technology. Organizations use multiple isolated systems to maintain and control their buildings, from fire and security alarms to access control, ventilation/AC and energy conservation systems) but currently are not efficiently nor centrally managed. In response to this challenge we develop SUD (Stillemans Univeral Dock), a system designed integrate and group any number of building systems in which different sensors, switches and other IOT devices exist controlled interactively through the Stillemans application (SAPP) and SDK. Using SUD, buildings can significantly be better managed as it integrates every IoT devices present under a single dashboard for smart decision making. This in turn will increase productivity, reduce energy consumption (as lights, heating and air conditioning can be started or stopped depending on determined parameters) and cut overall maintenance costs. SUD is a “best value” investment in building systems as it allows to manage building systems with unmatched depth while delivering a low-cost and easy implementation. We are a family owned company, founded by Joseph STILLEMANS in 1928. Currently, the company operates worldwide, and it is in the path of growth with 25% y-o-y growth since 2012. Based on our Initial business plan a business opportunity of more than 100,000 installed-devices arising for Stillemans.

Keywords: sensors,control,switches,wireless power,smart furniture,building management,isolated systems,security alarms
Gender and Bicycling Aesthetics: the potentiel for the sustainable city of gender construction processes across cycling practices, equipment and infrastructure. (SENCyclo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

Moving towards sustainable mobility will require improved understanding of the gendering processes across cycling mobility as the bicycle is a vector of sustainable lifestyles but gender norms still restrict its development. Research on gender and mobility neglects the sensitive materiality through which gender is constructed, and aesthetical approach of mobility infrastructure takes little interest so far in gender. To investigate how gender intersects with aesthetics in the ongoing formation of bicycling practices, equipment and infrastructure will lead to a better understanding of the potential of gender dynamics as an agent of change in creating more sustainable cities. The aesthetical experience of the bicycle has a key role in the continuous infrastructuring processes of bicycling practices, equipment and infrastructure. My main hypothesis is that the aesthetical experience also creates a tension with the dominant norms of feminity/masculinity, impacting the ongoing gender formation and deconstruction. The deconstruction of these unequal political categories constitutes an important step towards the development of more systemically sustainable cities. Focusing on French and Swiss cities at different stages in the implementation of their cycling policies, the research will develop an original interdisciplinary, comparative and multi-scale approach that deploys the concept of social imaginary to explore the spatial (micro)practices in relation to cycling materialities and ambiances, embodied experiences, meanings and representations, drawing on object-based, visual and mobile methodologies. It will cast light on affective and sensible resonances between infrastructure, environment, equipment and gendered bodies. In the longer term, to investigate the aesthetical dimension of mobility participates in the effort in research to overcome the curiously immaterial and disembodied conceptions of sustainability.

Keywords: bicycle mobility,mobility studies,mobility infrastructure