Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
POWER2DM - Predictive model-based decision support for diabetes patient empowerment (POWER2DM)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Germany,Türkiye,France,Netherlands,Netherlands,Netherlands
Call: Self management of health and disease and decision support systems based on predictive computer modelling used by the patient him or herself (H2020-PHC-2015-single-stage, 2015)
Start date: 2016-02-01
End date: 2020-12-31
Duration (months): 59.0
Total project cost (EUR): 4981553.75
EU funding (EUR): 4981553.75
Participants: 8
Project status: CLOSED

The main objective of POWER2DM is to develop and validate a personalized self-management support system (SMSS) for T1 and T2 diabetes patients that combines and integrates (1) a decision support system (DSS) based on leading European predictive personalized models for diabetes interlinked with predictive computer models, (2) automated e-coaching functionalities based on Behavioural Change Theories, and (3) real-time Personal Data processing and interpretation. The DSS will be based on the complementary combination of proven predictive models for short term plasma glucose prediction, medium term diabetes progression, and long term risk scoring for diabetes complications. These models will be integrated in adaptive personalized behavior change interventions to increase adherence of the patients to their care program and improve their interaction with health professionals. A cloud-based Data Integration Service, collecting and processing data from personal devices and EHR/PHR in real-time feeds the DSS. The results of the SMSS with respect to clinical parameters, awareness, acceptance and empowerment of the patient to participate in the care process will be evaluated in three studies in NL, DE and ES. The deliverables of the project will increase self-management capabilities and participation of the patient in the care process, resulting in better self-control and management of the disease. This will lead to better glucose management, thereby preventing severe episodes and long-term complications. POWER2DM will reinforce the prevention sector in healthcare by raising the acceptance of SMSS based on DSS that use predictive models fed by data from personal devices. POWER2DM will challenge individuals towards more frequent and long-term use of personal devices for self-monitoring, boosting the development of these devices. POWER2DM will thereby make an essential step forward in empowering the patient, advancing prevention and decreasing disease burden and costs.

Keywords: self management,diabetes,decision support systems,predictive computer models,patient empowerment
Eco-evolutionary dynamics of biological invasions reconstructed from ancient DNA (CloneInvasion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Invasive species are one of the major threats to the biodiversity on Earth but despite their bad reputation, they are also essential models for studying rapid evolution and adaptation, species colonization and climate change. Although great progress has been made in many areas of invasion ecology, there are still many open questions about the eco-evolutionary dynamics of invasive species and the evolutionary processes operating at different stages of species spread and invasion. I propose to study the invasive Japanese knotweed species complex to understand species colonization and range expansion by combining museomic (ancient DNA) from herbarium collections with high-throughput DNA sequencing technologies and bioinformatics. Specifically, I will compare data from historical and contemporary individuals to study (1) key transitions and drivers of plant colonization, range expansion, and invasion abilities, across space and time, (2) the role and implications of hybridization and ploidy variation in plant colonization and invasion and (3) identify the presence of genomic regions under selection.

Keywords: herbarium collections,museomics,spatial and temporal patterns of species range expansion,invasion stages
Enhancing skills intelligence and integration into existing PhD programmes by providing transferable skills training through an open online platform (DocEnhance)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Germany,Spain,Norway,Finland,Greece,Slovakia,Sweden,Switzerland,Belgium,Norway,France,France,Czechia,Netherlands,Luxembourg,Portugal,Ghana
Call: Research innovation needs & skills training in PhD programmes (H2020-SwafS-2019-1, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 990558.16
EU funding (EUR): 990558.16
Participants: 19
Project status: CLOSED

DocEnhance aims to enhance transferable skills intelligence and integration into existing PhD programmes by i) involving the non-academic sector in developing a more employment and innovation-oriented curriculum for PhD programmes, ii) facilitating work-based learning and business-education partnerships through developing PhD courses, and iii) tracking of PhD graduate career paths. The major outputs of the project are a recommended transferable skills curriculum for PhD programmes, a novel course concept and material, and an open access career-tracking survey. The project will focus on transferable skills, as these skills facilitate the transition into employment and are widely applicable, regardless of scientific field and chosen career path. All project outputs will be provided as freely available Open Educational Resources through an online platform, the DocEnhance Platform. This platform will function as a comprehensive, user-friendly and equal access point for transferable skills intelligence and training in research education for researchers in all career stages, as well as a community and networking site, designed to live beyond the project lifetime. DocEnhance builds on a large, diverse and experienced consortium, several existing EU-projects and other initiatives to achieve these ambitious goals. The External Advisory Board and the Industry Reference Group represent the major stakeholders and end users of the project outputs, and their involvement is ensured through a co-creation approach that includes project evaluation and validation events. All project outputs will be piloted among several European partner universities during the project for proof-of-concept, and a project partner from Africa and member university of the the World University Network represents the interests of non-European countries.

Keywords: transferable skills,open educational resources,co creation,career tracking,open access,online platform,lifelong learning,work based learning,data stewardship,innovation,supervision
Hierarchical surface patterns from dissolution-reaction-crystallisation mediated evaporation controlled self-assembly (DRC-ECA) and its antimicrobial coating application (DRC-ECSA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-04
End date: 2017-09-03
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

A preliminary study by the applicant (Dr. Hua Wu (HW)) has proposed a novel dissolution-reaction-crystallisation mediated evaporation controlled self-assembly (DRC-ECSA) mechanism, from surprising and unprecedented observations of complex residual surface patterns with hierarchical architecture self-assembled upon evaporative drying of a ZnO nanofluid droplet. This mechanism is very diﬀerent from that previously established for the coﬀee ring eﬀect and other ECSA processes, and the morphological and nanostructural details of the obtained surface patterns also depend intricately on – thus are tuneable by – a range of physical parameters. Much of the complexity due to these corroborating factors remains to be fully explored. The aim of the project is threefold: 1) to fully understand the DRC-ECSA mechanism by comprehensively investigating the effects of physical parameters such as the solvent mixtures, evaporation rate, ZnO nanofluid concentration, shape and size of ZnO particles, addition of surfactants and polymers, substrate chemistry, droplet volume, temperature and humidity; 2) to apply and extend the DRC-ECSA mechanism (e.g. in a confined geometry and using binary particle mixtures) to obtain sophisticated surface patterns with tailored morphologies and hierarchical structures; 3) to evaluate the efficacy of the surface patterns for potential applications in antimicrobial coatings. By leading and engaging in the proposed project, Dr. HW will acquire new skills and knowledge in a range of interdisciplinary and multidisciplinary scientific and technical areas, including non-equilibrium ECSA, nucleation and crystal growth, morphological and structural characterization, nanoparticle synthesis, and microbiology of nanostructured surfaces. A broad range of transferrable skills acquired through the enriching experience of this interdisciplinary project will be very beneficial to Dr. HW’s longer term career plans to become an independent research leader.

Keywords: evaporation controlled self assembly ecsa,non equilibrium crystalization,nanostructure self assembly,zno nanorods,surface patterns,coffee rings,antimicrobial coating
Multitasking Nanoparticles for Intracellular Bioimaging and Biosensing (NanoIntra)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-01
End date: 2020-04-30
Duration (months): 36.0
Total project cost (EUR): 258530.4
EU funding (EUR): 258530.4
Participants: 2
Project status: CLOSED

The development of specifically designed nanomaterials for advanced medical applications such as theranostics has become a major technical challenge with great potential societal and economic outcomes. Nanomedicine and related techniques hold great promises for improved diagnostic and treatment of widely spread diseases such as cancer. This project, entitled NanoIntra, aims at developing novel multitasking nanoparticles as advanced tools for highly localized and ultrasensitive intracellular imaging and biosensing. These nanoprobes should provide new insights in the spatial and temporal processes at play in live cells and therefore reveal part of their mystery. Such functional objects are achieved through the design of a complex architecture which involves quantum dots as bright and stable luminescent markers encapsulated in a protective silica matrix. These nanoparticles are combined with plasmonic nanocrystals, which offer new strategies for their photothermally induced intracellular delivery. The targeting and imaging of specific subcellular structures is then achieved thanks to proper surface functionalization of the nanoparticles. In addition, the plasmonic nanocrystals also allow these nanoparticles to be used as Surface Enhanced Raman Scattering (SERS) biosensors. Finally, for a higher control on the use of such nano-biosensors, optical tweezers are used to purposefully manipulate and position the nanoparticles inside the cells at the region of interest. Besides their application in cell labeling and biosensing, these functional nanoparticles have tremendous potential applications in the fields of theranostics, nanomedicine and nanobiophotonics, and NanoIntra constitutes a first step toward the development of a full lab-on-a-particle. Thus, through the synthesis and characterization of novel materials and their application to biotechnology, NanoIntra is a multidisciplinary research and training project at the interface between physics, chemistry and biology.

Keywords: silica,quantum dots,fluorescent,plasmonic,gold,surface functionalization,cell labeling,endosomal escape,sers,optical tweezers,theranostics,nanomedicine,nanobiophotonics
Role of CONSTANS in flower longevity (LONGFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Flower development plays a critical role in the life cycle of seed plants. Interconnected pathways as vernalization or photoperiod control the transition from vegetative to reproductive growth. On the contrary, flower senescence is considered the final event of flower development in annual plants, because it ultimately leads to the death of the flower. Although, both processes have been extensively studied, the connection between flowering signal and senescence is not yet fully understood. The precise timing of the floral transition is a key decision for a plant that is influenced by internal and external cues. In this sense, the photoperiod pathway regulates the response of the plant to the length of the day and to changes in light-driven circadian rhythms. In Arabidopsis thaliana, the gene CONSTANS (CO) represents a central hub that controls photoperiodic flowering induction. Although poorly understood, it is interesting that CO expression remains at high levels in the shoot apical meristem and floral organs. Why is CO expression maintained in these organs even when the flower developmental program has already been activated? Does it have a second role in flower senescence? The aim of LONGFLOW project is to determine CO expression patterns in flowers, discover its role in autophagy and flower senescence, and modify flower longevity by alteration of CO expression. The hypothesis is that CO, besides inducing flowering, could also induce autophagy and flower senescence through the activation of senescence (SAGs) and autophagy (ATGs) associated genes, as well as a possible role for Jasmonic acid signalling. Thus, by decreasing CO levels specifically in flowers, it could delay autophagy and senescence processes and obtain longer-lived flowers, an interesting applied output of the research activity.

Keywords: flower longevity,constans,autophagy,senescence
A multi-center randomized, placebo-controlled trial of mirabegron, a new beta3-adrenergic receptor agonist on left ventricular mass and diastolic function in patients with structural heart disease (BETA3_LVH)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Italy,Belgium,Greece,Poland,Greece,Belgium,France,France,France,United Kingdom,Portugal
Call: New therapies for chronic non-communicable diseases (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2022-08-31
Duration (months): 88.0
Total project cost (EUR): 5425112.99
EU funding (EUR): 5425112.98
Participants: 20
Project status: CLOSED

Patients with cardiovascular risk factors, e.g. hypertension and obesity are at risk of developing heart failure with preserved ejection fraction (HFpEF), a highly prevalent disease in the elderly, mostly women population. There is currently no specific, defined treatment for HFpEF, beyond control of risk factors. Activation of cardiac and vascular Beta3-adrenergic receptors (B3AR) represents a new concept and a novel target for structural cardiac disease. B3AR expression and coupling were demonstrated in human myocardium and vasculature. In pre-clinical models with expression of the human receptor, its activation attenuates myocardial remodelling, i.e. decreases hypertrophy and fibrosis in response to neurohormonal or hemodynamic stress. Mirabegron is a new agonist of B3AR available for human use, that was recently introduced for a non-cardiovascular indication (overactive bladder disease). The primary objective of the project is to design and implement a multi-centric, prospective, randomized, placebo-controlled clinical trial testing the additional beneficial effect of mirabegron, versus placebo over 12 months on top of standard treatment of patients carrying structural cardiac disease without overt heart failure (stage B of AHA classification); the co-primary end-point will be the quantitative change in myocardial hypertrophy measured by cardiac MRI; and in diastolic ventricular function, measured by Doppler echocardiography (E/E’); in addition, exercise tolerance (peak VO2) will be measured as well as circulating biomarkers reflecting both myocardial remodeling and function. In addition, we will test the effect of mirabegron on beige/brown fat activation and metabolism. Our proposal therefore combines a major conceptual advance and repurposing of an original drug to validate pre-clinical discoveries in the context of a major health problem.

Keywords: cardiac hypertrophy,diastolic dysfunction,adrenergic,beta3,clinical trial
Towards an objective and quantitative Assessment of human Corneal Transparency (TACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 2
Project status: CLOSED

Visual acuity is dependent upon the transparency of the cornea. Corneal transparency can be compromised by various pathologies, infections, trauma, ageing, and surgery, all of which result in increased light scattering. Lack of ocular anterior segment transparency is the leading cause of blindness worldwide, with corneal causes alone affecting over 10 million people. In current clinical ophthalmology practice, corneal transparency is usually monitored subjectively and qualitatively via direct focal illumination using a slit-lamp biomicroscope. Aside from inherent subjective and qualitative drawbacks, including poor reproducibility, this method lacks the capability to register and resolve changes in opacity that may be subtle. Hence, there is a critical need for a reliable and practical tool to objectively quantify, characterize, and monitor corneal transparency towards effective prevention, diagnosis, and treatment. The overall objective of this research programme is to address this unmet need by developing and validating advanced concepts and novel imaging modalities tailored to the needs of cornea assessment. The programme investigates (1) Quantitative Polarized Slit-lamp Biomicroscopy, (2) Multi-Wavelength Full-Field Optical Coherence Tomography (FFOCT), and (3) Multi-Illumination Matrix FFOCT; all enabling ease of use, high resolution, and deep light-penetration characterization and imaging. The candidate will be in an excellent position to carry out the programme under the auspices of the ideal host (Institut de la Vision) and the ideal partner (Institut Langevin). The research will enhance our basic understanding of corneal transparency as well as lead to major changes and improvements in patient care and management. It will, moreover, open new avenues and spur further investigations of ocular media transparencies. The Fellowship will enable the candidate to continue innovations at the interface of physics and ophthalmology as an independent researcher.

Keywords: ophthalmology,corneal transparency,light scattering,slit lamp biomicroscopy,full field ocular coherence tomography,light manipulation techniques
4D shape memory polymers via microstereolithography for production of thermally responsive stents (4D STENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Cardiovascular disease (CVD) affects nearly 18 million people globally (World Health Organization) as a result of heart attacks and strokes. The current treatment for CVD includes opening the restricted vessel through the use of stenting with a cylindrical tube made of a biocompatible metal or polymer, compressed and delivered by a catheter to the implant site. However, contemporary stents are severely limited as a result of poor biocompatibility, degradability, and manufacturing techniques. The 4D Stent project will utilize microstereolithography to produce biomaterials with controlled surface chemistries, bulk material properties, and possessing shape memory to give rise to 4D biomaterials, a potentially disruptive technological shift in medical device engineering. The produced stents will possess shape memory, controlled degradation and mechanical properties, and can be produced rapidly through photopolymerization. Thiol-ene click reactions, along with epoxide ring opening reactions, will be used to tailor biomaterial chemistries and engineer spatially-controllable printed prototypes, ultimately yielding stent surfaces that can be bio-orthogonally tailored to simulatenously recruit endothelial cells while preventing biofouling, all as post-polymerization processing. Here, Andrew Weems will combine his background in biomaterials engineering of shape memory materials with the synthetic expertise of Prof. Andrew Dove in the field of degradable polymers, and the practical cardiovascular surgical knowledge of Dr. Homer-Vanniasinkam to produce 4D stents of clinical relevance. Ultimately, 4D STENT has the potential to disrupt the medical device market, providing superior clinical support to European citizens and commercial entities by improving quality of life around the globe.

Keywords: photopolymerization,surface chemistry,shape memory polymer,stent,medical devices,additive manufacturing,stereolithography