Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Remote Ischemic Conditioning in Lymphoma Patients Receiving Anthracyclines. (RESILIENCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Spain,France,France,Netherlands,Netherlands,Portugal,Denmark
Call: New interventions for Non-Communicable Diseases (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 5998388.0
EU funding (EUR): 5998388.0
Participants: 18
Project status: SIGNED

The increasing life expectancy of the population and the development of effective therapies result in a growing population of aged cancer survivors, which frequently have comorbidities for developing heart failure (HF). Anthracyclines (AC) are still first line treatment for many cancer types, but up to 35% of patients who received them develop cardiotoxicity and HF. The trade-off between cancer and chronic HF is of massive psychological burden for patients, and of devastating economic consequences for healthcare systems. We aim to test the efficacy of a novel intervention (remote ischemic preconditioning) to reduce the incidence of AC-induced HF. We have selected Non-Hodgkin lymphoma as the target population, since it is diagnosed at advanced comorbid age in both genders. This will also allow us study gender differences in AC-induced HF. A phase II randomized clinical trial enrolling 608 patients undergoing AC chemotherapy will be done. Primary endpoint will be based on serial cardiac magnetic resonances exams. Taking advantage of the recruited population and data gathered, we will further validate 2 novel cardiac magnetic resonance imaging methods: a novel early marker of cardiotoxicity, and a new sequence allowing a massive reduction of acquisition time. We will also study a personalized strategy to empower patients in clinical trial execution, which includes Patient-Reported Outcome and Experience Measures (PROMs and PREMs). Our final goal is to reach the patient level by implementing the novel strategy at the clinical level while paving the way for a future large phase III trial. For this endeavour, we count on a multidisciplinary consortium, where different stakeholders of this process are part of the study, from scientists to industry, and from healthcare providers (physicians and nurses) to patients. RESILIENCE deals with 2 of the most frequent non-communicable diseases in Europe (cancer and HF), responsible for a big proportion of healthcare expenditures.

Keywords: heart failure,cancer,cardiotoxicity,anthracycline,cardioprotection,cardio oncology,haematology
Next generation bicycle lights. Be visible, understood and expected by other vehicles, whatever the weather, angle and situation. (Blinkers)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Switzerland
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The usage of the bicycle is increasing worldwide, especially in urban areas. Indeed, the bicycle is already the most used mean of transportation for more than 40 million EU citizens . However, cyclists remain the most vulnerable road users. Statistics clearly show that more than 55% of these accidents occur at crossroads, junctions and roundabouts in urban areas and currently cyclists lack appropriate technical equipment to keep them safe in such common traffic situations. Blinkers is the first holistic system incorporating lights and smart sensors to ensure complete visibility and predictability of cyclists. Such integration stands out when compared to other safety-related cycling accessories by truly improving visibility and predictability of the cyclist in any situation and from all angles of vision, solving the three cyclists’ fundamental problems in urban environments: 1) Visibility and predictability when changing directions; 2) Predictability when braking; 3) Safety space respected. To date, we have raised €475K from a crowd-funding campaign and two funding rounds. These funds, together with own funding, allowed us to invest into the development and testing of Blinkers to ensure its robustness and efficiency and move into the commercialisation stage. Within this innovation project we are now aiming at adapting the product to be compatible with bike sharing systems, where it is expected to make a direct contribution to the reduction of fatalities and severity of injuries. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of Blinkers and its market uptake.

Keywords: blinkers,lights,safety,cycling,bicycle,visibility,perimeter,smart
Straining electromechanical coupling in layered crystals to new extremes (STRAIN2EXTREME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 1766875.0
EU funding (EUR): 1766875.0
Participants: 1
Project status: SIGNED

Inherent stability of layered 2D materials supports a remarkably large strain along the plane of these 1-atom-thick crystals. For example, graphene and MoS2 can stretch, in principle, by 20% - ten times more than the typical intrinsic breakdown strain of 3D crystals. Such extreme deformations of the interatomic distance can drive exciting structural phase transitions, support fascinating electronic orders, and pro-foundly impact the electronic or optical response. Individually, however, pulling these ultimately thin materials to reliably approach their intrinsic limit poses great challenge. Cracks, defects, and out-of-plane motion all motivate early rupture, that prevented ap-plicable demonstration of extreme strains so far. STRAIN2EXTREME, instead, relies on recent advances in Van-der-Waals (VdW) structures; Sandwiched between thin impermeable layers the mechanical stability is reinforced, while suppressing unwanted chemistry and contamination at these "all-surface" materials. Notably, the minute amount of defects, dangling bonds, and disorder, do not pin-down the strain to relax locally to the rigid substrate as in com-mon interfaces. It results in a nearly frictionless sliding between the weakly interacting layers. Based on this finding, I set forward an entirely new approach to pull the structures while supporting them on a “super-lubricant” substrate. This support allows us to gradually narrow the shape into sub-micrometre constrictions, and "focus" a moderate pulling force to induce extreme local strains reliably. Moreover, we directly control the gradient of the strain in space by the precise shape. Remarkably, fixed strain gradients, can induce uniform “pseudo-vector-potentials” of extreme strength. Using the unique mechanics and outstanding lubricity of VdW structure, I intend to realize highly ballistic time-reversal-protected transport, demonstrate a new "pseudo-Hall" effect, and explore crystal-induced electromagnetic fields in moire' super-lattices.

Keywords: layered 2d materials,electro mechanical coupling,strain,graphene,gauge fields,spin hall effect,van der waals structures,super lubricity,superconductivity,pseudomagnetic fields,strain engineering
Advancing European Aquaculture by Genome Functional Annotation (AQUA-FAANG)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Spain,Germany,Italy,Italy,Poland,Greece,Norway,Norway,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Agri-Aqua Labs (H2020-SFS-2018-2, 2018)
Start date: 2019-05-01
End date: 2023-10-31
Duration (months): 54.0
Total project cost (EUR): 6355182.5
EU funding (EUR): 6000000.0
Participants: 25
Project status: SIGNED

Recent developments in genomics have advanced innovation in European aquaculture. However, despite the creation of reference quality genome sequences for the main species, our understanding of genome functions remains limited. AQUA-FAANG will deliver a step improvement in understanding of genome function and exploitation of genotype-to-phenotype prediction in the six most important European farmed fish species. The project brings together world-leading interdisciplinary expertise and industry partners providing direct pathways to commercial exploitation. AQUA-FAANG will functionally annotate the genomes of all six species, employing standardized experimental assays and analysis pipelines defined by the FAANG initiative. AQUA-FAANG datasets will be shared and coordinated with other FAANG initiatives via the FAANG data coordination centre, and made available through the Ensembl genome browser. As infectious disease is of paramount concern for sustainable aquaculture, the project focuses on understanding functional genomic regions in both healthy and immune-challenged fish. This will improve knowledge of the genomic basis for disease resistance and is complemented by novel approaches to increase understanding of immune cell heterogeneity. Standardized comparative analyses will provide essential insights into genome functions that cannot be gained from study of single species. Functional assays will be used to study intermediate phenotypes and prioritise causative genetic variants in trait-associated genomic regions to accelerate selection of disease-resistant stocks. Functionally-enriched marker panels will be developed to improve accuracy of genomic selection. An active programme of stakeholder engagement and dissemination will ensure uptake of project outputs by industry, academia, the public and in policy. The outputs will enhance precision breeding, drive competitiveness within the aquaculture sector, and enhance food and nutrition security in Europe.

Keywords: functional annotation of fish genomes
CONtributing to Shift2Rail's NExt generation of high Capable and safe TCMS. PhAse 2. (CONNECTA-2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Spain,Germany,Germany,Germany,France
Call: Implementing new technologies for the TCMS (H2020-S2RJU-CFM-2018, 2018)
Start date: 2018-10-01
End date: 2021-07-31
Duration (months): 34.0
Total project cost (EUR): 6150256.27
EU funding (EUR): 4305179.39
Participants: 10
Project status: CLOSED

Continuation project of CONNECTA (GA 730539) which targets the implementation and deployment in two laboratory demonstrators (for regional and urban segments) of the following technologies: - Wireless TCMS, including wireless train backbone and wireless consist network - NG-TCN including high safe (SIL4) communication networks to support the drive-by-data concept, including brake-by-wire. - Functional Open Coupling (FOC) - Functional Distribution Framework (FDF) instantiated with two different approaches (modified AUTOSAR and self-implemented on top of specific operating system), together with relevant application profiles - The virtual certification simulatiom framework, with hardware-in-the-loop and remote connectivity to subsystems The goal is to reach TRL5 in most developments.

Keywords: tcms
Industrial cooperation across continents (GNSS.asia2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Coordination and support actions
Countries involved: India,Germany,Taiwan, Province of China,China,Korea, Republic of,Belgium,France,Japan
Call: EGNSS awareness raising, capacity building and/or promotion activities, inside or outside of the European Union (H2020-Galileo-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 1154957.5
EU funding (EUR): 1153707.25
Participants: 9
Project status: CLOSED

GNSS.asia2 engages on pre-marketing activities and business development support for European Industry and EGNSS in the Asian region: GNSS.asia2 is building on GNSS.asia (FP7) which has established the foundations for concrete COLLABORATION BETWEEN EUROPEAN AND ASIAN INDUSTRY with already significant results with India, China, Taiwan, Korea and Japan: -Built an effective team by blending industrial cooperation professionals with GNSS experts -Developed a TOOLBOX of GNSSS communication instruments in LOCAL LANGUAGES -Established an INDUSTRIAL RELATIONSHIP PLATFORM through numerous workshops, seminars, round tables and communication activities -Enabled unique NETWORKING OPPORTUNITIES for European companies to showcase their products in Asia -Facilitated the INTRODUCTION OF GALILEO in Asian industry players’ products -Provided TRANSPARENCY ON ASIAN MARKETS, research input and contacts for GSA and industry -Engaged key GNSS stakeholders in Asia (industry, associations, institutes and gov’t agencies) Industrial collaboration in the GNSS downstream sector is becoming increasingly important as Galileo hits the market and services get tested. Half of the world’s population live in Asia and Asian high-tech companies supply GNSS-electronics to the world. The DIFFERENTIATORS OF GALILEO need to be underlined in the MULTI-GNSS HOTSPOT ASIA. European industry needs support in BUILDING INDUSTRIAL PARTNERSHIPS with Asian companies. GNSS.asia2 will create and deepen industrial relationships, promote EGNSS differentiators in Multi-GNSS, raise EGNSS AWARENESS in Asia. Our proven team will achieve this through PARTNERSHIPS WITH ASIAN GNSS STAKEHOLDERS like the MULTI-GNSS ASIA Campaign and a dedicated GNSS.asia INDUSTRY ADVISORY BOARD. The proposal is ENDORSED by more than 20 GNSS companies and organisations in Europe and Asia who would like to continue the successful partnership on GNSS industrial cooperation across continents.

Keywords: building industrial relationships between eu and asia,promoting galileo differentiators in multi gnss,market entry support to gnss companies
CPS Engineering Labs - expediting and accelerating the realization of cyber-physical systems (CPSELabs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Innovation actions
Countries involved: Spain,Germany,Germany,Germany,Sweden,France,France,France,United Kingdom
Call: Smart Cyber-Physical Systems (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-04-30
Duration (months): 39.0
Total project cost (EUR): 7654030.0
EU funding (EUR): 7437655.0
Participants: 10
Project status: CLOSED

Smart cyber-physical systems (CPS) are considered to be the next revolution in ICT with lots of game-changing business potential for integrated services and products. Mastering the engineering of complex and trustworthy CPS is key to implementing CPS-based business models. Current CPS, however, are often engineered and maintained at very high cost and sometimes with unknown risks, and recent technological progress from R&D projects is not readily available to most innovators. The CPS Engineering Labs (CPSE Labs) therefore equips innovators - businesses, researchers, and students - with CPS engineering infrastructure, knowledge, and tools for realizing novel CPS-based products and services, with the explicit goal of expediting and accelerating the realization of smart CPS. The CPSE Labs build upon existing R&D centres - in Madrid, Munich, Oldenburg, Newcastle, Stockholm, and Toulouse - and turn these already excellent regional clusters into world-class hotspots for CPS engineering. The design centers develop and maintain a common strategic innovation agenda for building up novel and complete CPS value chains. Based on this strategy the CPSE Labs build up and maintain a portfolio of added-value experiments. Experiments are focused and fast-track and they have a clear innovation objective; they build upon results and achievements from large-scale national and European projects on the rigorous design of embedded systems and CPS. Experience gained from experiments, validation results, and best practices, cross-cutting engineering principles that underpin the integration of cyber and physical elements of CPS are continuously integrated and disseminated by the CPSE Labs. The CPSE Labs' marketplace provides an open forum for sharing platforms, architectures, and software tools for the engineering of dependable and trustworthy CPS. The ultimate goal is to establish a CPS engineering framework which sets a world-wide standard.

Keywords: cps ecosystem building,knowledge an innovation community,autonomous systems,networked embedded systems,cross sectorial and cross disciplinary value chains
REsponsive theranostic nanosystems for Advanced Cancer Treatment (REACT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1498345.77
EU funding (EUR): 1498345.77
Participants: 1
Project status: SIGNED

REACT aims to dramatically impact the targeted release of diagnostic agents and drugs with nanomedicines that respond to biological cues or changing pathophysiological conditions, thus enabling ultrasensitive diagnosis and exquisite therapy selectivity. Nanomedicine research against cancer focuses on the local targeted delivery of chemotherapeutics to enhance drug efficacy and reduce side effects. Despite all the efforts in the design of chemotherapeutic agents as nanomedicines, hardly any improvement has been translated into benefits for patients’ survival. There is an urgent need for improved carrier systems able to deliver high doses of diagnostic agents and anti-cancer drugs to the tumor. Stimuli responsive carriers are promising candidates since the release of the cargo can be triggered locally in the tumor environment. Currently, there exists an unparalleled effort to identify genes, proteins and metabolites implicated in human disease and utilize systems biology and mathematical approaches in order to develop new prognostic tools for the treatment of cancer and develop more targeted therapies for patients. As an expert in drug delivery systems, the PI intends to bring all these efforts and advances into the design of stimuli responsive organic-inorganic hybrid nanoparticles that can adapt their response to the biological milieu. The novel engineered delivery systems will consist of an inorganic porous matrix surface-modified with tumor-specific molecules with the ability to sense changes in the environmental conditions and react by providing a proportional release. These nanosystems can potentially be employed for early in vitro diagnosis through effective screening of deadly tumors, such as neuroblastoma and glioblastoma. Moreover, through the sustained delivery of the nanosystems from injectable gels that can be locally implanted in patients at risk of developing a tumor, a clinically relevant tool for in vivo diagnosis and targeted therapy can be achieved.

Keywords: drug delivery,theranostic,stimuli responsive,mesoporous silica nanoparticles,chemotherapy,hydrogel,injectable,imaging,cancer
Innovative Food Product Development Cycle: Frame for Stepping Up Research Excellence of FINS - FOODstars (FOODstars)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Serbia
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2015-12-01
End date: 2018-11-30
Duration (months): 36.0
Total project cost (EUR): 999281.25
EU funding (EUR): 999281.25
Participants: 3
Project status: CLOSED

This proposal is related to the work programme topic Twinning, H2020-TWINN-2015. The specific challenge of the will be achieved by significant strengthening of the research capacities of the Institute for Food Technology, Serbia (FINS) in the area of FOOD TECHNOLOGY in close collaboration with internationally-leading research institutions: Teagasc - Agriculture and Food Development Authority, Ireland (TEAGASC) and University of Bologna, Italy (UNIBO). Transfer of knowledge will be achieved through short-term trainings, schools, thematic workshops, study visits, joint publications and various outreach activities and will consequently allow FINS to carry out efficient and high quality research that will be transferable to industry. S&T capacity of the linked institutions will be enhanced, new ideas and scientific challenges offered and further activities and joint applications for internationally funded projects enabled. The project partners are chosen on the basis of previous cooperation and reciprocal knowledge of respective expertise. The Work Plan summarized as “The Innovative Food Product Development Cycle” consists of six Work Packages, WPs. WP 1, WP 2 and WP 3 are designed to strengthen the scientific excellence and innovation capacity of FINS . The creation of preconditions for the implementation of innovative food solutions in industrial scales and the commercialization of research results will be performed by activities within WP 4. WP 5 is devoted to dissemination and networking activities and exploitation of results in order to establish a communication bridges between research community and industry and strategic and durable cooperation with partner institutions. WP 6 is designed to enable smooth project execution according to standard procedures and a straightforward management structure. This proposal offers the idea of generating new knowledge and turning it into new products and services as a direct response to wider economic and social challenges.

Keywords: innovative food product development cycle,food technology,enhancement of sandt research capacity