Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Delivering the next generation of open Integrated Assessment MOdels for Net-zero, sustainable Development (DIAMOND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Austria,Norway,Cyprus,Italy,France,Netherlands,Canada,United States,Switzerland,United Kingdom
Call: Improvement of Integrated Assessment Models in support of climate policies (HORIZON-CL5-2022-D1-02, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 3850922.5
EU funding (EUR): 3850922.5
Participants: 20
Project status: SIGNED

Recent literature has underlined the interplay among climate mitigation, adaptation, and finance, as well as between climate action and other development agendas, including sustainable resource use, human development and equity, and environmental pressures. Such an interconnected policy environment requires an integrated ecosystem of disciplines, methods, and tools. Despite the significant evolution of integrated assessment models (IAMs) in the last decade, there remain several criticisms on their design, use, and adequacy to respond to unaddressed and emerging questions in the light of the Paris Agreement and net-zero ambition. These include openness, legitimacy, and ownership, as well as technical feasibility to represent demand-side and broader societal transformations, cross-sectoral interactions, physical impacts and adaptation, climate finance and labour dynamics, and other sustainability goals. DIAMOND will update, upgrade, and fully open six IAMs that are emblematic in scientific and policy processes, improving their sectoral and technological detail, spatiotemporal resolution, and geographic granularity. It will further enhance modelling capacity to assess the feasibility and desirability of Paris-compliant mitigation pathways, their interplay with adaptation, circular economy, and other SDGs, their distributional and equity effects, and their resilience to extremes, as well as robust risk management and investment strategies. This will be done via integration of tools and insights from psychology, finance research, behavioural and labour economics, operational research, and physical science. We will develop a transdisciplinary scientific approach to legitimise the implementation process and co-create research questions that stretch the frontiers of climate science, as well as establish vibrant communities of practice to transparently open model enhancements and to develop capacities, thereby lowering the entrance barriers to the established IAM community.

Keywords: integrated assessment models transparency open science communities of practice capacity development interdisciplinary science transdisciplinary science sustainable development impacts finance
Developing a novel Parkinson's disease drug using small molecule mimetics of Glial cell line-Derived Neurotrophic Factor (GDNF) (KevadBio)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 2338056.0
EU funding (EUR): 1636639.0
Participants: 1
Project status: SUSPENDED

GeneCode is developing a novel anti-PD drug that contains a central nervous system penetrant compound imitating GDNF peptide pathway activation that alleviates both motor and non-motor symptoms in PD patients, protecting and restoring lesioned dopamine neurons as well as potentially increasing dopamine levels in brain tissue. GeneCode’s unique solution uses small-molecule compounds that penetrate the blood-brain barrier, target the GFL receptor complex (containing GDNF protein) and mimic GFL (GNDF family of ligands) biological effects in neurons, promoting survival in the affected dopaminergic neuronal pathways. Once fully developed, the PD drug would be administered weekly or less frequently as an oral treatment. Considering the importance of GDNF family ligands and/or RET-signalling pathways for other groups of cells, applications of compounds developed by GeneCode are not limited to PD, but can be applied to cure other medical conditions such as neuropathic pain, addiction, ALS etc.

Keywords: neurodegeneration,ind enabling studies,glial cell line derived neurotrophic factor,small molecule mimetics,central nervous system,parkinson s disease,neurochemistry and neuropharmacology,biotechnology,gfl receptor complex,drugs
UPscaling deep conversion routes for hard-to-reCYCLE biogenic waste (UPCYCLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Slovenia,Belgium,Spain,Germany,Switzerland
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 3790184.4
EU funding (EUR): 3790184.4
Participants: 14
Project status: SIGNED

As prevention strategies are struggling with respect to some waste categories, biogenic hard-to-recycle streams represent a critical issue, hindering circular bioeconomy and resulting in severe environmental pollution phenomena. The Waste Framework Directive and the EU Green Deal indicate the need for developing pioneering value chains to address the challenge in compliance with sustainability targets. A set of promising thermochemical processes emerged, both in dry (pyrolysis, gasification) and wet aqueous (hydrothermal carbonisation, hydrothermal liquefaction) phases, with their application still limited by technical and non-technical barriers. The UPCYCLE DN will train the next generation of professionals in the upscaling of these deep conversion technologies for hard-to-recycle biogenic waste and will provide innovative tools for the design of feasible waste upcycle solutions to high-value secondary materials. Such ambition will be achieved by developing an integrated methodology combining cutting-edge experimental and modelling techniques at various scales (molecular, reactor and process) and by covering the entire value chain in continuity with relevant stakeholders. Several priority waste streams will be targeted, namely highly contaminated and poorly reactive sewage sludge and derived products from municipal and industrial wastewater treatment as well as highly contaminated lignocellulosic materials. The UPCYCLE partners will work synergistically to generate a cohort of 15 well-trained young researchers with a unique multi-disciplinary set of skills, not limited to technical ones, with the goal of making them the future research leaders or entrepreneurs capable of bringing forward a paradigm shift. At once, the project will pave the way for large-scale deployment of sustainable technologies on which a new generation of biorefineries could rely.

Keywords: sewage sludge lignocellulosic waste chemical recycling thermochemical processes multiscale modelling reactor engineering process simulation lca tea resource recovery biorefinieries
Development of bottom-up custom-functionalized graphene/porphyrin nanoarchitectures with atomic precision (GRAPHYRIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

The ongoing miniaturization of electronic devices has been raising awareness for the need to develop alternative high-performance and energy-efficient semiconductor materials. The current project (GRAPHYRIN) aims to synthesize new atomically precise hybrid nanoarchitectures, comprising graphene nanostructures (graphene nanoribbons, GNRs, or nanoporous graphene, NPG) and porphyrins (PORs), with promising properties to fabricate next-generation materials to be used, for example, in gas sensing electronic devices. First, multistage organic synthesis will be carried out to obtain individual or fused precursors of GNRs and PORs (“seeding stages”), which will later allow the construction of partially and fully conjugated hybrid systems. Here, we will synthesize appropriate bianthracence-based reactants (or equivalent derivatives) as molecular building blocks of GNRs and, in parallel, several PORs (tetra- or di-substituted) with appropriate structural features to functionalize GNRs. Alternatively, POR-fused GNRs hybrid precursors will be synthesized via direct functionalization of PORs with GNRs precursors or via synthesis of GNRs precursors bearing aldehyde groups. Several polymerization strategies will be explored (“growing stages”), using in-solution synthesis (ISS) or on-surface synthesis (OSS), namely on Au(111) surfaces. The polymerization reactions will involve, for example, Suzuki or Ullmann coupling. Depending on the properties of the starting GNRs and POR precursors, the final structures may either be one- or two-dimensional (1D GNRs/PORs or 2D NPG/PORs, respectively). Finally, the successfully synthesized hybrid materials will be explored as gas sensors for future electronic devices. It is expected that the outcomes from GRAPHYRIN will allow to go beyond the state-of-the-art and take a step further towards the synthesis of new custom-made graphene/POR nanoarchitectures for ideal gas sensing electronic devices.

Keywords: graphene nanoribbons nanoporous graphenes porphyrins gas sensing
CAUSATION: Assessing causal relationships in Macroevolution (CAUSATION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

Throughout earth’s history, a myriad of factors has driven biodiversity patterns. During the lifespan of lineages, biotic and abiotic variables might act differently in shaping the diversification dynamics of organisms. Therefore identifying and quantifying their relative importance is crucial for a better understanding of past and current biodiversity patterns. This is particularly relevant for complex systems involving multiple functional groups spread through different trophic levels, e.g. the system composed of browsing and grazing animals and the plants they consume. The dynamics of the whole system can be affected not only by the biological components but also by environmental factors. Recently, new methods have been proposed to directly address causal associations between time series, based on dynamic systems theory, which represents an advancement in relation to traditional correlation-based approaches. This proposal will assess the causal associations between the diversity of each component of the plant-herbivore system to have a better understanding of the mechanisms involved in the regulation of biodiversity in macroevolutionary timescales. Using the “Empirical Dynamic Modelling” (EDM) approach, which is a non-parametric approach specifically designed to address causality in time series, I will test the performance of this approach when using simulated and empirical macroevolutionary time series, applying it to the diversity time series of the components of the plant-herbivore system. This project will produce a critical examination of the performance of the EDM approach in this context, as well as produce direct information on the causal associations between the diversity of different groups and the influence of environmental variables on the dynamics of the whole system.

Keywords: macroevolution,diversification,empirical dynamic modelling,palaeontology
Collaborative Housing in Operation - Maintenance of benefits and Evidence (CollabHOME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-14
End date: 2026-10-13
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Collaborative housing models provide some form of collectivism and community ownership connected to the ownership and use of the housing. Initiatives aim to address problems of housing affordability and quality, as well as provide other social benefits to residents and the surrounding neighborhood through the provision of intermediate tenure between full ownership and renting. As housing pressures grow across Europe and internationally interest in this form of housing has grown. However, there is currently a lack of evidence regarding the extent to which these initiatives are able to provide affordability for residents and other social benefits in the medium to long term whilst respecting the rights of individuals. CollabHOME aims to understand how collaborative housing tenures are performing in operation, regarding these goals of housing affordability for residents of the initiative and other social benefits, and in relation to existing legal and policy frameworks. There is a growing body of research exploring the processes through which such housing projects are developed, their relationship to the state and the social relation of living within such communities. This project will contribute to this field through examining the maintenance phase of these projects and understanding the way that tenure is structured in these models. CollabHOME will conduct nine case studies of collaborative housing initiatives across three national contexts in order to model the inflection points of interaction of collaborative housing initiatives with prevailing legal, policy and social frameworks to understand how and if affordability and other benefits are maintained. It will also map housing tenure types internationally according to a model of rights and responsibilities and collateevidence of maintenance of affordability and long-term goals. Through these activities, CollabHOME will produce valuable evidence on the performance of collaborative housing over time.

Keywords: collaborative housing,tenure,co operatives,community land trusts
ION beams for Neuromorphic EDGE computing (ION4EDGE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

ION4EDGE project introduces a revolutionary approach to edge AI computing with our ultra-low power, low latency and adaptable neuromorphic chips. By leveraging our patented ion beam process to customize magnetic tunnel junctions, we have developed a novel Analog in-memory computing architecture that mimics the synaptic metaplasticity of the human brain. Our technology overcomes both catastrophic forgetting and reduces device variability, two major challenges in current AI hardware especially for edge applications. By enabling a unique spintronic synapse architecture and continuous learning, ION4EDGE will transform edge computing by drastically reducing latency and power consumption compared to traditional architectures. We will pave the way for next-generation of AI applications including smart cities, healthcare, consumer electronics, and industrial automation, while contributing to Europe's technological sovereignty in the semiconductor industry.

Keywords: neuromorphic,artificial synapse,artificial neural network,binarised neural network,spintronics,metaplasticity
PIVOT, a thrust-vectoring hybrid Unmanned Aerial System (UAS) that provides ultra-high-resolution spatial data for the offshore inspection market. (PIVOT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 3600000.0
EU funding (EUR): 3600000.0
Participants: 1
Project status: SIGNED

The inspection and maintenance of offshore assets is a highly regulated process fraught with risks to both equipment and personnel. Regulators and insurance companies mandate a minimum of one inspection per year, with additional inspections required after adverse events. However, challenging marine weather conditions and difficult-to-access locations often lead to the neglect of these recommendations. Traditional methods involving climbers and marine helicopters and sea vessels are not only costly but also require onboard crew, putting lives at risk. Orthodrone addresses these challenges with its innovative PIVOT UAS, a hybrid unmanned aerial system (UAS) designed for gathering ultra-high-resolution spatial data in challenging environments. PIVOT leverages patent-pending thrust vectoring stabilization technology, ensuring the main body of the drone remains stabilized throughout the flight. The system supports high-precision, helicopter-grade sensor payloads, such as Phase One metric cameras and Riegl LiDAR, ensuring superior data accuracy. The PIVOT UAS reduces operational costs by 75%, lowers carbon footprint by 38 times compared to helicopters, and also provides enhanced environmental resilience. It offers unparalleled data precision with millimetre-level accuracy, extended flight times of up to three hours, and robust safety measures by eliminating the need for personnel in the field. These features make PIVOT a cost-effective, environmentally friendly, and safer solution for offshore inspections and other high-risk sectors. Orthodrone’s objectives for the EIC project include optimizing the PIVOT solution, conducting rigorous validation in partnership with industry leaders, and expanding business development efforts across Europe. These steps will ensure that Orthodrone continues to meet and exceed the evolving needs of its customers for spatial data acquisition.

Keywords: offshore inspection,aerial survey
Metabolic regulation of the skeletal stem cell niche (MERLIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Czechia
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499821.25
EU funding (EUR): 1499821.0
Participants: 1
Project status: SIGNED

The continued health of many of our organs, including the skeleton, relies on the function of specialized stem cells. These stem cells reside in niches that support their long-term maintenance. Disruption of the niche due to aging, injury, or genetic mutations, can lead to declines in stem cells and a failure to maintain and repair tissues. Compared to our understanding of the stem cells that maintain and repair our skeleton, we know much less about the cell types that constitute their niche. My prior large-scale genomics studies have uncovered a novel niche cell type for the skeleton. Intriguingly, these niche cells are defined by a unique metabolic profile, highlighting in particular enzymes for Phenylalanine (Phe) / Tyrosine (Tyr) metabolism and glycogen synthesis. Traditionally, it has been thought that Phe/Tyr are degraded primarily in the liver, and the skeletal malformations in patients with Phenylketonuria (mutation in PAH), Tyrosinemia (I-III, mutations in FAH, TAT, HPD) and Alkaptonuria, a.k.a. "black bone disease" (mutation in HGD) has been interpreted as the results of systemic intoxication by accumulated metabolites. My dogma-shattering result suggests that local regulation of Phe/Tyr degradation might be a critical strategy to support the skeleton. I will establish a research group that leverages the powerful genomic, genetic, and high-resolution imaging strengths of zebrafish to test the requirements of niche cells in skeletal stem cells homeostasis and the roles of metabolism in stem cell maintenance. Findings from my proposed studies will inform future therapies aimed at correcting metabolic diseases and restoring stem cell function and skeletal health by modulating the niche.

Keywords: stem cells,niche,metabolism,animal model,skeleton,zebrafish
Advanced technology for cognitive rehabilitation (MindLenses)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

In the European Union, it is estimated that approximately 20 million individuals over age 55 have MCI. The societal and economic cost of dementia in Europe is estimated to increase to over €250 billion by 2030. Approximately 50% of these costs are attributable to care provided by informal carers (e.g., family members and close friends), who provide on average 5 hours of care and supervision per day. MCI presents significant challenges in the realm of neurodegenerative disorder, as currently there is no standard treatment. To respond to these needs, we have developed MindLenses, a cutting-edge medical device and digital therapy for cognitive rehabilitation. It emerges as a transformative solution as it seamlessly integrates non-invasive neuromodulation through prismatic lenses and serious games, pioneering a novel approach to cognitive enhancement. Despite its healthcare burden and prevalence, effective solutions for treating MCI remain elusive. Research indicates that 41% of patients don’t seek treatment due to inadequate access to healthcare services in rural or remote areas and a desire to avoid dependency on prescription drugs. We request the EIC support to perform a multicenter clinical study that will consist of 60 patients in 3 clinical sites in Italy and Spain and pursue regulatory approval as a class IIa device according to MDR; with this we will enter the market in 2028.

Keywords: mci,alzheimer,cognitive rehabilitation,non invasive neuromodulation,prismatic adaptation,digital therapy,home device