Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIOmethane as SUstainable and Renewable Fuel (BIOSURF)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Germany,Germany,Italy,Germany,Austria,Italy,Belgium,Hungary,France,France,United Kingdom
Call: Market uptake of existing and emerging sustainable bioenergy (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 1872912.13
EU funding (EUR): 1872912.13
Participants: 12
Project status: CLOSED

The objective of BIOSURF (BIOmethane as SUstainable and Renewable Fuel) is to increase the production and use of biomethane (from animal waste, other waste materials and sustainable biomass), for grid injection and as transport fuel, by removing non-technical barriers and by paving the way towards a European biomethane market. This objective will be achieved through the following founding pillars: - National biomethane registries - Cooperation among the national biomethane registries - European mass-balancing system for biomethane - Free Market Biomethane Trade - Sustainable raw material supply - Methodology for entitlement to CO2 certificates - Regional specificities - Networking and Cooperation - Transferability of results beyond the project’s countries. BIOSURF relates, within the Work Program 2014-2015 on Secure, clean and efficient energy, to the Call COMPETITIVE LOW-CARBON ENERGY, namely the topic LCE 14 – 2014/2015: Market uptake of existing and emerging sustainable bioenergy. The qualifying ideas of BIOSURF are: • To develop a value chain analysis from production to use depending on the territorial, physical and economic features (specified for different areas, i.e., biofuel for transport, electricity generation, heating & cooling); • To analyse, compare and promote biomethane registering, labelling, certification and trade practices in Europe, in order to favour cooperation among the different countries and cross border markets on the basis of the partner countries involved; • To address traceability, environmental criteria and quality standards, so aiming to reduce GHG emissions and indirect land-use change (ILUC), to preserve biodiversity and to assess the energy and CO2 balance; to identify the most prominent drivers for CO2-emissions along the value chain as an input for future optimization approaches; • To exchange information and best practices all along Europe concerning biomethane policy, regulations, support schemes and technical standards.

Keywords: biomethane,production,market,registries,sustainability
Multifunctional Hierarchically-Structured Systems for Energy Storage Devices (MATISSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-05
End date: 2021-08-04
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The widespread use of portable devices, as well as the electrification of transport, require a new generation of energy storage devices that deliver higher specific performance than Li-ion batteries. By designing multifunctional materials that combine structural and electrochemical energy storage, an improvement in gravimetric and volumetric efficiency can be achieved. The research aim of this project is to develop Energy Storage Devices based on multifunctional hierarchically-structured systems. The success of the project will be driven by the combination of two strong and complementary areas of expertise: At Imperial and IMDEA, the fellow will work for 24 months in groups with an extensive experience of carbon and inorganic nanomaterials synthesis, modification, characterisation, and application, particularly on hierarchical systems. On the other hand, she will bring her own experience in developing and characterising electrodes and electrolytes for a wide range of batteries as well as supercapacitors. The interdisciplinary intersection of new materials chemistry, with electrochemical device engineering, and structural composite mechanisms, will provide a unique opportunity for rapid progress in both science and technology. The structural energy storage devices will be developed from technology readiness level 1 and to 4, in order to accelerate direct impact on industrial applications, for example in the automotive and electronics sectors. During the two-year project, the fellow and supervisor will disseminate their results to Industry, Academia and General Public through patents and articles in podcasts, newspapers and scientific journals. From the start, an individual career development plan for the fellow will be developed with the supervisor and will be reviewed regularly during the fellowship. Prof. Shaffer’s talents for both research and teaching will inspire the fellow to launch ambitious research and educational projects early in her academic career.
Ground-breaking and convenient electronic bicycle fleet management system available for the mass adoption. (LockAndCharge)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy,Slovenia
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

As the concept of bicycle sharing gains tremendous momentum due to the pressing need for green and efficient inner city travel arises, the market space opens up for the right platform to enter and address these concerns. Enter the Lock & Charge solution, an electronic bicycle (ebike) fleet management system which streamlines management, safety, and commerce into a single easy-to-use platform for clients and end-users through using their mobile devices. In an innovative mix of engineering and business finesse, Lock & Charge allows 1) One-stop easy fleet management for clients through its control centre application 2) One-stop easy usage of services for end-users through its ‘ebike rider’ application 3) Affordable market entry for clients only requiring 1 ebike, 1 lock, and 1 dock station to start their businesses 4) Effective theft prevention through a siren alarm, tracking system, and steel jacketed cables. 5) And inclusivity for all riders based on their needs (e.g lower horse-power for the elderly, smaller ebikes for children etc.) Lock & Charge has already established key sales channels in line with its go-to market strategy of establishing ebike fleets in co-working office locations, already implementing 2 trials fleets with raving results. It is currently at a pivotal stage requiring additional funds to 1) Engineer universal chargers into the dock stations, ensuring battery charging for all ebikes types, allowing accessibility to a wider range of customers . 2) Complete software and application optmization and integration with the lock and dock station equipment for all functionalities to work seamlessly for end-users and clients.

Keywords: electronic bicycle,bicycle sharing,green transportation,city transportation,transportation,fleet management,bicycle lock,bicycle charge,mobile application
Modular wood-made wind turbine towers (Modvion)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Modvion AB is a company founded in 2016 with the purpose of developing and constructing a wood-made modular wind turbine tower. Further to its founding, the Modvion team grew constantly, highly specialized people joining the company. This led to the development of our first patent and to other patent application with pending status. We are bringing to market a modular wind turbine tower made from laminated wood (LVL). Our technology allows towers to have a larger diameter base which increases its strength properties and supports a larger tower. By using engineered wood such as LVL, we are able to develop a structure 53% stronger than its steel counterpart and be part of getting wind turbines to even larger heights. Our turbine tower can go well beyond 150 meters in height and can support a 350 tons heavy nacelle and turbine. Our turbine tower outperforms existing solutions on the market, such as steel and concrete wind towers, in terms of specific strength, operational costs, maximum height and many more. In terms of environmental impact, our product shows a zero impact and, compared to alternatives, this impact goes well beyond what is available on the market. As a system made of wood, our turbine tower hold the CO2 captured by trees during their growth and trapped in the tower. The amount of CO2 trapped in a Vultus tower is of 2,000 tons (in a 150-meter tower) The main target of this Phase 1 is to improve our business plan, focusing on updating a previous market assessment. We want to update our business model based on the changes in the renewables market, with risk and IP assessment as secondary analyses.

Keywords: wind power,environmental footprint,renewables
Measure of Alkaline Phosphatase Activity of Plankton: An Integrated Microfluidic Approach (MAPAPAIMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Climate change is affecting the hydrodynamics of the world’s oceans and lead to an increase of the ocean stratification. This ocean stratification tends to trap phytoplankton in the nutrient depleted surface layer. To survive to this extreme environmental condition, some phytoplanktons can activate a set of enzymes (such as alkaline phosphatase) and use the dissolved organic matter as a nutrient source. Although measurement of the alkaline phosphatase activity can be performed with accuracy, no existing method can follow in real-time and at the single cell level the physiological adaptation such as the release of alkaline phosphatase by phytoplankton. As a consequence, no experimental evidence can directly link the alkaline phosphatase enzyme activity found in a sample to an individual. In this context, we plan to develop a new complete microfluidic system in order to better examine which species release alkaline phosphatase, in which extend and how the environmental conditions predicted in the future (Temperature and CO2) modify this enzymatic activity. This new microfluidic system will integrate in a same chip, a screening procedure based on the cell morphology, an incubation system, and an enzyme assay at a single cell level. Measurements of the kinetic of alkaline phosphatase will be performed by using two enzyme labelled fluorescence methods and time-lapse analyses. Three main results are expected from this project. Firstly, the microfluidic device will be capable to encapsulate a wide spectrum of plankton species in single microenvironment. Secondly, the development of the automatic identification system based on the new image processing algorithm will create an easy method to classify planktons depending on their morphologies. This method could be purposed as valuable commercial application. The third technology developed in this study will be the creation of new tunable microenvironment capable to maintain target plankton alive during enzyme analyses.

Keywords: microfluidic,plankton,phosphorus limitation,alkaline phosphaste activity,real time image processing
Using cell-cell interactions to unlock new cancer treatments: Forcing neural crest tumors back onto the developmental path (KILL-OR-DIFFERENTIAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Austria,Sweden,France,United States
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-10-01
End date: 2026-09-30
Duration (months): 72.0
Total project cost (EUR): 9377151.0
EU funding (EUR): 9377151.0
Participants: 6
Project status: SIGNED

The interactions between tumor and its microenvironment are often critical to uncovering the mechanisms of tumor survival. A striking example is the recent success of immunotherapy approaches that expose tumor cells to immune attack by disrupting a specific interaction between the tumor and infiltrating lymphocytes. The tumor can also repress immune response by inducing complex interactions among dozens of immune and stromal cell types that typically make up tumor microenvironment, however those remain largely uncharacterized as we currently lack systematic approaches to uncover relevant cell-cell interactions. The alternative to killing tumor cells, either directly or through immune system, is to force them to differentiate. Such strategy is particularly promising for tumors arising due to failure of progenitor populations to follow proper differentiation cascade. Here as well, the progress has been limited by lack of understanding of specific intercellular signals that that are disrupted in tumorigenesis. We propose a systematic approach for characterizing cell-cell interactions in complex microenvironments through joint analysis of spatially-resolved and disassociated single-cell transcriptomics. We will apply it to identify inter-cellular signals and pathways that can push tumors of neural crest origin, including as pheochromocytoma (PCC), paraganglioma (PGL) and neuroblastoma (NB), towards terminal differentiation. Building on our expertise with neural crest development, we will use single-cell profiling to map individual tumor cells onto developmental trajectory of neural crest differentiation. Spatial transcriptomics analysis will then be used to identify the sources and nature of microenvironment signals that channel neural crest differentiation during normal development. Contrasting interactions in normal and tumor tissues we will then aim to identify factors, pathways or signals that would push that PCC, PGL and NB tumors towards benign state.

Keywords: neural crest,neuroblastoma,differentiation,cancer,single cell transcriptomics,2d transcriptomics,development,tumor,pheochromocytoma,sympatho adrenal differentiation
Dominant cis-regulatory variation to improve quantitative traits in polyploid wheat (dcPolyWheat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1999994.0
EU funding (EUR): 1999994.0
Participants: 1
Project status: SIGNED

Urgent action is needed to sustainably intensify global crop production using science-based solutions. Across crops, selection for mutations in cis-regulatory regions of transcription factors has been at the centre of the domestication and breeding process to improve productivity traits. Further efforts to advance towards this goal, however, are hampered in the young polyploid genome of wheat as many genes are present as two or three homoeologous copies with overlapping functions. As a result, recessive variation at single loci is often masked by redundancy with homoeologous copies. This understanding, together with the recent breakthroughs in wheat genomics and gene editing approaches, allow us to now propose an innovative strategy to overcome the perennial problem of functional redundancy in polyploid wheat. The aim of this proposal is to use state-of-the-art genomics to produce a novel framework that defines the cis-regulatory landscape of the polyploid wheat genome. I hypothesise that targeting mutations to cis-regulatory regions of transcription factors will result in dominant alleles within the polyploid context. Through genome editing approaches, I will engineer novel dominant alleles that should result in an unprecedented step change in wheat phenotypic variation, with the potential to improve productivity traits. I will benchmark this novel phenotypic variation with that achieved through recessive loss-of-function mutants in the same transcription factors and their putative downstream genes. Upon completion, I will deliver publicly-accessible germplasm with unique and novel variation that will enhance wheat productivity traits beyond what is traditionally possible. This project paves the way to apply similar approaches to other polyploid crops and will demonstrate the transformational impact of innovative genetic solutions towards addressing food security.

Keywords: wheat,polyploid,genome editing,breeding,yield,grain development,genomics,mutants,rna seq,networks,transcription factors
Informatics and Statistics for Advancement of Research Success (iSTARS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal
Call: ERA Chairs (H2020-WIDESPREAD-2018-2020-6, 2019)
Start date: 2021-01-01
End date: 2026-12-31
Duration (months): 72.0
Total project cost (EUR): 2499998.75
EU funding (EUR): 2499998.75
Participants: 1
Project status: SIGNED

With iSTARS, “Informatics and Statistical Tools for the Advancement of Research Success”, FMUL (School of Medicine at Lisbon University) proposes to take advantage of the ERA Chair mechanism to enact true transformational change that will promote excellence in research and competitiveness in acquisition of funding. We will recruit a top scientist and team in the area of medical informatics/data science, to do state-of-the-art research in these areas. As vast amounts of data are produced in medical practice and research, a capability to analyse that data and extract information becomes crucial for research success at a Medical School. This is lacking at FMUL, and we believe that the foundational and cross-cutting nature of data science for medical research makes this a unique project. The objective is not just for the ERA Chair holder to conduct great science in medical data science, which in itself will promote excellence, rather the goal is for she/he to collaborate across the Institution and help transform the way other researchers at FMUL do science. At the same time, iSTARS will provide resources for the ERA Chair that will allow not only better science, but professionalization of project management, funding procurement, and outcomes communication. The work packages and activities planned are built around three key excellence axes: i) scientific; ii) advanced training; and iii) a translational program. Excellence in science through the ERA Chair expertise and leadership; advanced training in data science, project management, communication and ERA Priorities (e.g., gender mainstreaming and open science); a translational program to collaborate with stakeholders and sustainability beyond iSTARS. In summary, we believe that iSTARS responds to the objectives, goals and scope of the call and we have defined this project to enhance excellence in scientific projects at FMUL, with impact in the research and innovation landscape of the Institution, Region, and beyond.

Keywords: data analytics,medical informatics,biostatistics,big data,clinical research,study design,data analyses,artificial intelligence in medicine
Teneurin interactions in the neuronal synapse (TEN-COMPLEX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: TERMINATED

Synapses, connections between neurons, are critical to the formation of neural circuits. Functional neural circuits control intricate processes such as learning and memory, whereas failure in neural circuitry formation can lead to developmental disorders including autism. At the molecular level, synapse formation is enabled by cell-adhesion molecules that interact across the synapse. At present, many individual proteins have been identified that contribute to synaptic cell adhesion, but it is unclear how these individual proteins team up in macro-molecular complexes. I will focus on synaptic cell-adhesion complexes containing Teneurins, a protein family whose essential role in synapse formation has only recently been characterized. To understand how Teneurin complexes promote synapse formation, I aim to determine the molecular mechanisms that underlie Teneurin1 and Teneurin2 dimerization, including complex formation with their recently identified binding partner Latrophilin. To achieve this goal, I will determine the structure of Teneurin protein complexes using single particle electron cryo-microscopy. In parallel, I will study the function of Teneurin complexes in synapse formation using primary hippocampal neurons. Dissecting the molecular mechanisms that underlie Teneurin functions might ultimately advance small molecule therapeutics to treat developmental diseases, including autism. The work I propose here, draws upon my background in the field of developmental neurobiology, but complements that background with new knowledge and skill sets in structural biology to set me off conducting my own line of research as an independent scientist.

Keywords: cell adhesion,macro molecular complexes,synapse,single particle electron cryo microscopy