Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enabling Decentralised Digital Twin Era in existing Research Infrastructures for Predictive, Preventive, Personalised, and Participatory Health (DTRIP4H)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Finland,Spain,Netherlands,Czechia,Lithuania,Belgium,Romania,Germany,Estonia,France,Portugal,Greece,Cyprus
Call: AR/VR-empowered digital twins for modelling complex phenomena in new RI application areas (HORIZON-INFRA-2024-TECH-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 13998986.5
EU funding (EUR): 11998387.21
Participants: 26
Project status: SIGNED

In the face of a rapidly advancing digital healthcare terrain, the DTRIP4H project emerges as a momentous effort to revolutionize predictive, preventive, personalized, and participatory health paradigms within the EU. Amid significant incidence of chronic conditions and cancer, there is a pressing need for a proactive shift in health strategies. Yet, the full potential of European research infrastructures (RIs) is curtailed by investment deficits, fragmentation, and the intricacies of data management. Digital Twin (DT) technology introduces a new age of precision by enabling sophisticated simulations and analyses of intricate biological processes. In DTRIP4H, we start a new initiative in Europe “decentralized health digital twin ecosystem consisting of RIs”. Using DTs, we aim to resolve critical challenges around data harmonization, equitable access, and stringent privacy safeguards. Incorporating technologies such as federated learning, Generative AI, and Virtual Reality (VR), the project aspires to create a decentralized digital twin environment (DDTE). This will empower both internal and external RI users, such as researchers, innovators, and SMEs, to craft DT applications that address specific scientific challenges, utilizing a blend of real-world and synthetic data in compliance with regulatory frameworks, i.e. GDPR. We will develop 7 innovative proof of concept thematic health-related Use cases fulfilling the needs of scientists, SMEs, and industrial end users, particularly in health topics related to cancer treatment, drug development, human environmental exposome, precision treatment for schizophrenia and personalized medicine through Artificial Intelligence (AI), AR/VR empowered DTs utilizing DDTE, while adhering to FAIR data principles. DTRIP4H adopts a human-centric methodology to elevate research efficacy, narrow the skills gap, and align with the objectives of the European Research Area (ERA) and the Sustainable Development Goals (SDGs) by 2030.

Keywords: digital twins,research infrastructure,decentralised digital twin environment,healthcare
Analysis of Transferrin Conformational changes that Impact Virulence and Evolution (ATRACTIVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 169326.72
EU funding (EUR): 169326.72
Participants: 1
Project status: CLOSED

Structural dynamics define the transition from one protein state to another and are modulated by interactions with partners-ligands and/or chemical modifications. They are important to control protein biological activity, govern protein evolution and their alteration can lead to diseases or death. The long-term objective of ATRACTIVE is to understand protein structural dynamics, their regulation and how such dynamics diversify a conserved structural core to evolve in computing distinct functions. For this, we will focus on human serum transferrin (hTF), which shares an ancient and conserved bilobed structural core composed of two domains from the type-II periplasmic binding protein domain family. This core is fundamental for maintaining iron-homeostasis in human cells conferring nutritional immunity. The same core is harbored by proteins ubiquitous throughout the tree of life that diversified yielding transcription factors, enzymes or transport related/signaling proteins. Bacterial pathogens to acquire iron from available sources, have evolved membrane receptors for capturing iron-loaded-hTF, transferrin binding proteins A and B (TbpA/TbpB). This interaction is essential for the pathogenicity of many critical human pathogens, such as Neisseria sp (gonorrhoeae, meningitidis). Our aim is to investigate the structural dynamics modulated by iron binding and release and how such are affected by the receptors in the presence or absence of drugs, following a three-pronged approach: a) Determine the structural dynamics of hTF upon iron binding in the two bilobed structures and uncover the allostery between them, b) Map the structural changes triggered by hTF-TbpA-TbpB interactions that underlie the iron release mechanism, c) Identify drugs that compromise the hTF-TbpA interaction. To do so, cutting-edge multi-disciplinary tools will be adopted: a. smFRET, b. HDX-MS, c. Molecular-dynamic simulations, d. In vitro binding assays and ITC.

Keywords: structural dynamics,smfret,hdx ms,protein evolution and function,bilobed structural core,human serum transferrin,iron homeostasis
The Newsroom: AI-powered information triangulation for accelerated fact-checking and surfacing of different perspectives (The Newsroom)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: European Social Innovation Competition
Action type: Recognition Prize
Countries involved: Portugal
Call: The European Social Innovation Competition 2024 (HORIZON-EIC-2024-EUSIC-PRIZE-04, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

The Newsroom's AI-powered platform is a revolutionary solution designed to contrast misinformation and break filter bubbles, addressing challenges at the very core of digital democracy. Through best-in-class AI, The Newsroom performs multilingual, cross-contextual analysis of thousands of news articles daily and enables journalists to produce high-quality, well-rounded articles more efficiently, in turn fostering an informed and engaged public. Unlike traditional approaches, our AI co-pilot supports journalists throughout the entire news production process—from research and contextualization to information validation and integrity. This toolset is unique within the European media landscape, amid critically low trust in news and rampant misinformation. Our platform features a user-friendly interface requiring minimal training and boasts a 99/100 score in Lighthouse testing for accessibility, as it was designed for accessibility and inclusivity. It is accessible to journalists of all technical backgrounds and abilities, with affordability ensured through a flexible model. Extensive testing and case studies confirm high adoption and satisfaction rates. Our solution directly tackles the competition challenge by enhancing journalism quality and promoting diverse perspectives. Partnerships with major publishers, tech firms, NGOs, open source leaders and academic institutions ensure industry relevance and impact, while pilot projects demonstrate significant impact on newsroom workflows. Financial and environmental sustainability as well as the platform's scalability and replicability are evidenced by successful adoption and our future product and business roadmap. Robust governance and transparency protocols ensure compliance and build trust with journalists and the public. The Newsroom's AI platform is a transformative tool for digital democracy, addressing disinformation, connecting democratic actors, and empowering civil society through innovative, inclusive technology.
Reliable Powerdown for Industrial Drives (R-PODID)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Türkiye,Portugal,Netherlands,Czechia,Latvia,Italy,Greece,Lithuania,Germany,Austria,Romania
Call: General according to ECS-SRIA 2022 (RIA) (HORIZON-KDT-JU-2022-2-RIA, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 23440004.16
EU funding (EUR): 7183297.85
Participants: 35
Project status: SIGNED

R-PODID (Reliable Powerdown for Industrial Drives) aims to develop an automated, cloudless, short-term fault-prediction for electric drives, power modules, and power devices, that can be integrated into power converters. Thereby, electrical and mechanical faults of machines and of the power converters driving them will become predictable within a limited prediction horizon of 12-24h. This will enable a power-saving shutdown of a larger number of production machines during idle times, because a looming failure during the next power-on cycle can be reliably foreseen. It will also enable reliable mitigation of dangerous faults in applications using modern power-devices like silicon-carbide (SiC) and III/V-semiconductor devices like gallium-nitride (GaN).

Keywords: artifical intelligence,intelligent systems,multi agent systems electrical and electronic engineering semicondusctors,components,systems smart manufacturing
A new technology of in-situ observation datasets to address climate change effects in hard-to-reach forest areas (RemoTrees)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Innovation actions
Countries involved: Italy,Germany,Spain,Romania
Call: New technologies for acquiring in-situ observation datasets to address climate change effects (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 3311300.0
EU funding (EUR): 2999180.38
Participants: 8
Project status: SIGNED

Forests play a key role in the Earth climate system as they cover about 30% of the land area. In the last decade they absorbed more than 7 Gt of CO2 contributing to reduce global warming and to buffer and mitigate increasing climate variability. The summers of 2018 and 2019 included some of the hottest and driest periods ever recorded globally, however the extent and severity of their impact is unknown due to lack of a comprehensive monitoring network, which generally does not include hard-to-reach areas characterised by strong logistic limitations. Therefore, novel technological solutions are urgently needed to monitor forest responses to climate change and related extreme events also in remote areas. Recent advances in Internet Of Things technology (IoT), satellite IoT connectivity and energy harvesting systems are opening unprecedented opportunities for the use of IoT devices in standalone experimental setups. In this context, the aim of the RemoTrees project is to design and build an innovative, autonomous in-situ monitoring system designed for remote forest areas and providing data via satellite communication to a dedicated RemoTrees platform. In this framework, RemoTrees will integrate existing and novel Earth Observation (EO) data with in-situ observations of Essential Climate Variables (ECVs: fraction of absorbed photosynthetically active radiation, leaf area index, soil moisture, biomass change) and other key variables including e.g. stem growth, stem moisture, sap flow, canopy transmittance, besides air humidity and temperature. RemoTrees will include study cases on interoperability with GEOSS (Global Earth Observation System of Systems), and on how in-situ data can support an improved understanding of the climate variability impact on forests. The reinforced in-situ component will be beneficial for Copernicus products validation and will enhance the assessment of climate change long-term mitigation and adaptation potential of forests, towards novel insights for climate-smart forest management.

Keywords: forests,essential climate variables
Unraveling the Supramolecular Architecture of Molecular Machineries in Adaptive Immunity (ImmunoMachines)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2499938.0
EU funding (EUR): 2499938.0
Participants: 1
Project status: SIGNED

To combat daily threats of pathogens and abnormal cells, the human organism features a sophisticated defense mechanism called the adaptive immune system. In broad terms, this intricate mechanism is triggered by specific peptide epitopes presented on molecules of the major histocompatibility complex class I (MHC I), which are scanned by cytotoxic T cells. Intracellular transport, loading, and cell-surface recognition of antigenic peptides on MHC I are orchestrated by machineries, the peptide-loading complex (PLC) and the T cell receptor (TCR) complex. The PLC is composed of multiple subunits, including the antigen translocation unit TAP, the MHC I heterodimer, and several chaperones ensuring that only stable peptide-MHC I molecules are released to the cell surface for decoding by TCR complexes. Ligand binding and the supramolecular organization of TCR complexes are translated into phosphorylation of conserved tyrosine-containing cytosolic sequence motifs that initiate downstream signaling cascades. Based on their incredible efficiency and selectivity, we hypothesize that the biogenesis of MHC I is highly processive and coupled via allosteric networking, and that antigen processing and recognition machineries are compartmentalized by a defined supramolecular organization. However, despite their fundamental importance, these architectural details of the PLC and the TCR, as well as the dynamic networking that is included in the quality control of the endoplasmic reticulum (ER) and receptor signaling processes, remain enigmatic due to their inherent dynamics, low abundance, and complexity. This ambitious proposal will contribute to a long-awaited holistic understanding of the machineries that shape the vertebrate adaptive immunity. The expected findings from this project will be groundbreaking in understanding the hidden processes of epitope selection and reception in human disease.

Keywords: membrane proteins,macromolecular complexes,er quality control,molecular chaperones,membrane transporters,membrane receptors,cryo em,fluorescence labeling,chemical biology,single molecule techniques,super resolution microscopy,receptor clustering
Medieval French Lyric Across Linguistic Borders: Music, Imitation, and Intertextuality (MUSICA FRANCA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1497467.0
EU funding (EUR): 1497467.0
Participants: 1
Project status: SIGNED

MUSICA FRANCA will investigate the role music played as a shared medium of communication across medieval Europe, enabling texts and ideas to travel across linguistic and political borders. Indeed, medieval poets and performers thought of melodic borrowing and re-use as constitutive to the process of creation. By investigating melodic imitation, intended as a range of techniques (from borrowing stylistic features to the reuse of entire melodies) in French, Galician-Portuguese, German, and Occitan lyric, from the 12th up to the first half of the 14th century, this project proposes to uncover a network which today appears to us as silent, but which profoundly shaped European intellectual history. The project will implement digital resources to encode and analyse melodies of the four repertories and explore their interconnections. The project’s main aims are: • To define a cohesive methodology for analysing melodic imitation across European lyric repertories, leveraging digital tools to uncover hitherto unknown melodic connections. • To provide a new methodological framework for the study of medieval aesthetics of imitation. This transdisciplinary methodology aims to integrate literary, philological, and musicological studies with network theory, in a translingual perspective. • To offer new topographic representations of medieval Europe, tracing the networks expressed by exchanges of texts and music and their interrelations with their cultural context. • To demonstrate how processes of imitation across different linguistic areas contributed to shaping European identities and a shared musical culture. The project will produce a series of monographs on musical imitation in medieval Europe, along with two main digital outputs: • The complete digital edition of the music of the trouvères. An interactive platform of geographical networks of musical imitation in medieval Europe.

Keywords: romance philology,digital musicology,trouv res
Elucidating the Superior Colliculus-related network properties and modulation in Huntington's Disease mouse model to delay the onset and ameliorate severity of the motor symptoms (HD-SC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-10-31
Duration (months): 25.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Neurodegenerative movement disorders e.g. Huntington’s Disease (HD) predominantly involve progressive motor symptoms as a result of disrupted basal ganglia neuronal networks. These symptoms are accompanied by early occurring deficits in visual perception and oculomotor functions, which share neuronal circuits with motor domains, and can be used in the prediction of the onset and severity of HD pathogenesis. Therefore, understanding the early circuitry alterations in HD progression is crucial to develop new disease-modifying strategies. The superior colliculus (SC) is a sensorimotor structure that receives and integrates visual information to control reflexes and is involved in visual perception and oculomotor functions. Functional MRI and behavioural studies demonstrated that the HD symptomatic mouse model show alterations in the SC function, but its role in motor symptoms has not been directly addressed. The HD-SC project proposes that (i) SC is an important factor in the basal ganglia circuit alterations found in HD, (ii) topographically segregated SC outputs provide differential contributions to the motor and defensive behaviours, and (iii) temporal control of SC neuronal plasticity with novel phytochromes will cause delay and amelioration in motor symptoms in HD model. This will be addressed using a combination of mouse behavioural, histological and biochemical phenotyping to reveal the onset of SC-related alterations in the HD model. Then, by using DREADDS we will determine the differential representation of SC outputs in motor and defensive behaviour. Finally, we will test the capability of phytochromes to modulate SC neuronal plasticity and delay and ameliorate motor symptoms in the HD model. Overall, the HD-SC aims at bringing a spotlight to mechanisms causing symptomatic resilience in the HD model, which potentially could be implemented in other neurodegenerative movement disorders with basal ganglia circuit alterations.

Keywords: huntington s disease,basal ganglia,superior colliculus,phytochromes,defensive behaviour,optogenetic
Metaraminol Demonstration Plant as Commercialisation Blueprint for Sustainable Production of Pharmaceuticals using Enzyme Cascades (SusECAS - DemoPlant)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-10-01
End date: 2024-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The development of more environmentally friendly synthesis methods is urgently needed if humanity wants to maintain an environment worth living in. The establishment of more biocatalytic steps in chemical synthesis is a possible solution, as enzymes and whole cells offer sustainable advantages such as biodegradability, toxicity, high selectivity and much more. Amino alcohols and 2-hydroxy ketones are valuable compounds with various applications in the chemical and pharmaceutical industry with market prices >1000 €/kg, but challenging synthesis strategies. As a result of synthesis options with disastrous footprints, these molecules are often produced in countries with poor working conditions and significantly lower safety and environmental standards than those accepted in the EU. The idea of 'SusECAS - DemoPlant' is simple. An innovative economic and ecological competitive process will enable a sustainable production of amino alcohols in Europe. In the ERC Starting Grant project 'LightCas', Prof. Rother laid the base with an atomic and step-efficient enzymatic 2-step reaction for amino alcohols from inexpensive starting materials (<10-100 €/kg). In 'SusECAS' we will take these innovative synthesis ideas to a new level of industrial application. A multi-gram demonstration plant will enable model-based process evaluation, giving us and our customer’s clear indications of the ecological and economic potential. A systematic market analysis will provide an overview of the competitive structure of the overall market, the market volume and the requirements of potential customers. Supported by business angels, commercialization strategies will be evaluated. In 'SusECAS', we will develop a business plan for commercialization and initiate a step-by-step market introduction of our products and technologies.