Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Researchers' Night Apulia 2018-2019 - Discovering the fascinating world of research (ERN-Apulia)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy,Italy,Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-04-01
End date: 2019-11-30
Duration (months): 20.0
Total project cost (EUR): 171000.0
EU funding (EUR): 171000.0
Participants: 9
Project status: CLOSED

ERN-Apulia targets to bring Apulian population closer to the research world and viceversa. Apulia is an Italian region with about 4.1 million inhabitants (approximately 7% of the whole Italian population), with 4 public universities having a total of about 2750 permanent researchers in addition to those from the Public and Private Research Institutions. Thus, ERN-Apulia has a large capacity of potential contributors and beneficiaries, which increases the overall impact of the planned initiatives. Our main objectives are: - to plan and implement preparatory events (during the year) and two ERN (2018 and 2019) where researchers meet the society, with particular attention to students, industrial and professional organizations, municipalities and public administrations; - to increase public awareness and recognition of the importance and impact of research in daily life, with specific examples from ICT to health and life sciences, from elementary particle to astrophysics research, from robotics to the preservation of cultural heritage, etc; - to stimulate curiosity and interest and explain the fascinating world and the opportunities in research, especially to the youngest as a mean to encourage them to embark scientific careers; - to establish a tight connection among population/institutions and researcher to continue during the year; - to prepare and publicize dissemination materials along with scientific games and site visits (including laboratories and sites of cultural interest) to be available during the whole year for the general public; - to explain the spirit and opportunities of the European Research Area, the H2020 agenda, the Marie Skłodowska-Curie actions and the principles of “The European Charter for Researchers”; - to reach a number of followers close to 500,000, a number of participants larger than 200,000 (among all the various initiatives) and a number of participants to the ERN larger than 100,000.

Keywords: european researchers night,research dissemination,outreach,public awareness
Food Nutrition Security Cloud (FNS-Cloud)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Germany,Ireland,Italy,Italy,Spain,Germany,Italy,Austria,Italy,Serbia,Slovenia,Belgium,Greece,Greece,Switzerland,Bulgaria,Belgium,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Food Cloud demonstrators (H2020-SFS-2019-1, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 11008132.67
EU funding (EUR): 10189549.91
Participants: 36
Project status: SIGNED

FNS-Cloud will overcome fragmentation problems by integrating existing FNS data, which is essential for high-end, pan-European FNS research, addressing FNS, diet, health, and consumer behaviours as well as on sustainable agriculture and the bio-economy. Current fragmented FNS resources not only result in knowledge gaps that inhibit public health and agricultural policy, and the food industry from developing effective solutions, making production sustainable and consumption healthier, but also do not enable exploitation of FNS knowledge for the benefit of European citizens. FNS-Cloud will, through three Demonstrators; Agri-Food, Nutrition & Lifestyle and NCDs & the Microbiome to facilitate: (1) Analyses of regional and country-specific differences in diet including nutrition, (epi)genetics, microbiota, consumer behaviours, culture and lifestyle and their effects on health (obesity, NCDs, ethnic and traditional foods), which are essential for public health and agri-food and health policies; (2) Improved understanding agricultural differences within Europe and what these means in terms of creating a sustainable, resilient food systems for healthy diets; and (3) Clear definitions of boundaries and how these affect the compositions of foods and consumer choices and, ultimately, personal and public health in the future. Long-term sustainability of the FNS-Cloud will be based on Services that have the capacity to link with new resources and enable cross-talk amongst them; access to FNS-Cloud data will be open access, underpinned by FAIR principles (findable, accessible, interoperable and re-useable). FNS-Cloud will work closely with the proposed Food, Nutrition and Health Research Infrastructure (FNHRI) as well as METROFOOD-RI and other existing ESFRI RIs (e.g. ELIXIR, ECRIN) in which several FNS-Cloud Beneficiaries are involved directly.
New Frontiers in Propellane Chemistry (NewPropChem)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-21
End date: 2024-02-20
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Propellanes are molecules of high importance as precursors to valuable cage molecules in pharmaceutical and materials research. For smaller-ring propellanes, ubiquitous reactivity can be displayed towards anions, radicals, and cations; however, the theoretical basis for this unusual behaviour has only recently emerged, which is based on the ability of small ring propellanes to delocalise electron density away from the electron-rich central C–C bond onto the peripheral carbon atom p orbitals both in the ground state, and during reactions. In this project we develop chemical tools to test this theoretical model, offering experimental support and characterising the change in structure and electronics during ring opening processes. We further develop new synthetic methodology to access high-value (but hard to access) chiral propellane ring-opening products, and explore new modes of propellane reactivity by employing novel catalytic concepts to activate the central C–C bond. We use a theoretical 'carbene' description of [1.1.1]propellane to open up access to bridge-substituted propellanes, which represent a 'holy grail' of the field, and also explore methods to control the dimerisation or oligomerisation of these molecules. Collectively, using the most up to date theoretical models (and in collaboration with theoretical chemists) we aim to develop a new frontier of propellane chemistry, which has the potential for broad impact on its many applications.

Keywords: propellanes,catalysis,mechanistic studies,theoretical calculations
Highly efficient and trustworthy electronics, components and systems for the next generation energy supply infrastructure (PROGRESSUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Germany,Italy,Italy,Italy,Italy,Italy,Italy,Germany,Italy,Italy,Spain,Germany,Spain,Slovakia,Slovakia,Netherlands,Netherlands,Netherlands,Netherlands
Call: ECSEL-2019-2-RIA (H2020-ECSEL-2019-2-RIA, 2019)
Start date: 2020-04-01
End date: 2023-09-30
Duration (months): 42.0
Total project cost (EUR): 19563845.36
EU funding (EUR): 5785389.68
Participants: 28
Project status: SIGNED

Progressus supports the European climate targets for 2030 by proposing a next generation smart grid, demonstrated by the application example “smart charging infrastructure” that integrates seamlessly into the already existing concepts of smart-grid architectures keeping additional investments minimal. The expected high-power requirements for ultra fast charging stations lead to special challenges for designing and establishing an intelligent charge-infrastructure. As emission free traffic concepts are a nascent economic topic also the efficient use of charging infrastructure is still in its infancy. Thus, novel sensor types, hardware security modules, inexpensive high bandwidth technologies and block-chain technology as part of an independent, extendable charging energy-management and customer platform are researched for a charging-station energy-microgrid. Research of new efficient high-power voltage converters, which support bidirectional power flow and provide a new type of highly economical charging stations with connected storage and metering platform to locally monitor the grid state complements the activities. The stations are intended to exploit the grid infrastructure via broadband power-line as communication medium, removing the need for costly civil engineering activities and supplying information to the energy management solutions for utilization optimization. Smart-Contracts via block-chain offer a distributed framework for the proposed energy management and services platform. Furthermore hardware security hardens the concept against direct physical attacks such as infiltration of the network by gaining access to the encryption key material even when a charging station is compromised. Progressus solutions are estimated to enable a carbon dioxide saving of 800.000 tons per year for only Germany, will secure the competitiveness of European industry and research by extending the system know how and will thus safeguard employment and production in Europe.

Keywords: power conversion,energy management,microgrid,charging infrastructure,blockchain,tmr sensor,hall sensor,fast charging,smart charging,local storage,hardware security,trusted hardware
DevelOp interdisciplinaRy apprOaches to healTH crises collaborativelY’ (DOROTHY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 5517000.0
EU funding (EUR): 2758500.0
Participants: 1
Project status: SIGNED

Responding to the need to equip European societies with multi-disciplinary expertise to tackle future public health crises, DOROTHY COFUND will recruit, train and launch the careers of 25 excellent fellows through 36-month fellowships (18 months overseas and 18 months in Ireland). Postdoctoral researchers from all disciplines will be eligible (e.g. epidemiology, engineering of materials, diagnostic tools, psychology, economics, social history, education, sociology, political science, medical and health humanities and philosophy), as long as their research projects fall within the remit of public-health crises. DOROTHY's goals are: -Support fellows’ career development, through excellent training and supervision and mentoring, and prepare them for future career opportunities by means of the exceptional skills and timely and topical experience that will be gained through these fellowships. - Create a critical mass of well-networked experts, from all disciplinary areas, who will be fully able to engage with the Irish and EU innovation ecosystem, through the set-up of an innovative multidisciplinary research and training platform. These individuals will be trained to tackle future public-health crises in ways that will lead to positive societal impact. -Promote the dissemination and communication of impactful research beyond traditional academic channels, targeting policymakers and population at large , with the objective of contributing to resourceful and resilient societies. - Pioneer an innovative multidisciplinary approach to the way public health crises are understood and tackled. As they are broad-ranging and complex phenomena, with multi-issue implications, solutions cannot prescind from the cooperation between disciplines, sectors and research areas. DOROTHY, which shows the feasibility of that, aims to become a replicable template for multidisciplinary, international and intersectoral training approaches.

Keywords: public health crises,global health,interdisciplinary health,health communication,public health policy,environmental health
Development of a new disruptive semiconductor technology to produce more efficient, smaller, lighter, and more robust power switches. (3C-SiC Si)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Anvil Semiconductors has developed a unique technology to enable the production of Silicon Carbide (SiC) power switches at a similar cost to conventional Silicon by growing thin layers of SiC by heteroepitaxy on Silicon wafers rather than using expensive bulk SiC substrates. This innovation enables wafer costs to be reduced by a factor of 20 and opens up the possibility of fabricating SiC devices at similar costs to those of Silicon. Power devices such as MOSFETS and Schottky Barrier Diodes (SBDs) utilising Anvil’s SiC technology instead of silicon enable systems to be more efficient, smaller, lighter, cheaper and more robust. Electronic systems for electric vehicles, industrial machines, photovoltaics, LED lighting, wind turbines, power factor correction, uninterruptible power supplies, and the Smart Grid, will all be more efficient, smaller, more robust and cheaper. Examples of customer benefits from the use of such devices include: 10% savings on fuel consumption in a hybrid car; critical efficiency savings (4%) and size reduction (25%) in solar inverters; 10% increase in efficiency power usage in data centres.

Keywords: power devices,semiconductors,mosfet,power efficiency,carbon footprint,pv inverter
Numerical and ERT stUdies for Diffusive and Advective high-enthalpy systems (NERUDA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2021-04-02
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

The full development of geothermal energy is still hindered by the little knowledge available on the distribution of high-enthalpy fluids at depth and by the often-complex logistics. High-enthalpy hydrothermal systems preferentially develop in tectonically active and volcanic settings. In such environments, faults have a major control on fluid flow and may affects the overall fluid distribution at depth. However, due to the lack of in situ data, predicting the role of faults on fluid flow is challenging and often requires complementary methods. NERUDA proposes an innovative and multidisciplinary approach, combining numerical simulations of fluid flow with deep Electric Resistivity Tomography (ERT). The project aims at constraining the tectonic control on fluid flow in hydrothermal systems. High-enthalpy environments often have a multi-layered structure with deep reservoirs (>300 m). Classical cable-structured ERT methods cannot reach such depths. To tackle this challenge, NERUDA will use a leading-edge technology in the field of ERT methods. The newly developed IRIS Fullwaver system allows the acquisition of deep (up to ~1 km) 3D ERT surveys. This wireless system can be deployed in areas with sharp topography (e.g. volcanoes) where classical ERT is logistically not possible. Numerical simulations of fluid flow, calibrated on the interpreted ERT surveys, will be performed to assess the fault control on fluid flow. The currently available flow simulators are either not user-friendly or lack some functionalities to adequately study high-enthalpy hydrothermal systems. NERUDA will develop an open-source, user-friendly MATLAB hydrothermal module calibrated on deep ERT to investigate high-enthalpy hydrothermal systems. This module will be implemented in the world-widely used, open-source MRST (MATLAB Reservoir Simulation Toolbox). NERUDA is expected to have a strong impact on the scientific community by widening the accessibility to user-friendly numerical tools.

Keywords: high enthalpy hydrothermal system,tectonics,volcanic environments,numerical modelling,geophysical imaging
DNA MEthylation for HPV-related disease among women living with HIV (MEsHH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-05
End date: 2020-09-04
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Background: The current screening methods for cervical cancer screening among women living with HIV (WLHIV) have previously shown high sensitivity but poor specificity for the detection of high-grade cervical intraepithelial neoplasia (CIN2+), resulting in over-referral for colposcopy and overtreatment of cervical lesions that may have low potential for progression to cancer. Methylation changes of human genes or HPV DNA have been reported early in carcinogenesis but their validation for predicting CIN among WLHIV is lacking. Objectives: Among 1238 WLHIV enrolled in Burkina Faso (BF; n=615) and South Africa (SA; n=623), the MesHH study aims to evaluate the performance of the DNA methylation of human genes (CADM1, MAL, MiR and EPB41L3) and HPV (HPV16/18/31/33) for the detection of prevalent and incident CIN2+ compared to, or in combination with, other screening methods (visual inspection using acetic acid [VIA] or Lugol’s iodine [VILI], cytology and HPV DNA) and to evaluate the capacity of the DNA methylation markers to distinguish cervical lesion progression, persistence or regression at 16 months follow-up. Methods: The study will use endocervical swabs with matching histological data collected as part of a prospective study evaluating cervical cancer screening strategies among WLHIV in BF and SA. The DNA methylation assays for human genes (CADM1, MAL, MiR, EPB41L3) and HPV (HPV16/18/31/33) will be performed using pyrosequencing assays. Sensitivity, specificity, positive and negative predictive values for the detection of CIN2+ will be estimated for the various DNA methylation markers, as stand-alone or multiplex tests. Relevance: Multiplex DNA methylation assays including a combination of human genes and HPV virus may have potential as primary screening for CIN2+ among WLHIV. DNA methylation assays also have the potential to be performed using the same clinician- or self-collected sample used for cytology or HPV testing, thereby increasing screening coverage.

Keywords: human papillomavirus,cervical intraepithelial lesions,invasive cervical cancer,human immunodeficiency virus,dna methylation,human genes,hpv virus
Mechanisms linking stress and ageing in two avian species exhibiting contrasted natural resistance to stress (NAtural REsistance to Stress-Induced Cellular Ageing) (NARESICA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Previous research has identified stress exposure as a key factor influencing health state and ageing rate. The overall aim of the proposed project is to investigate the precise mechanisms linking stress exposure to accelerated cellular ageing (using telomere length as a biomarker of ageing), and to identify potential mechanisms allowing some species to better prevent stress-induced ageing than others. To this aim I will use two avian species (Japanese quail and king penguin) to investigate (1) if chronic stress affects telomere shortening differently between species exhibiting contrasted stress resistance, (2) if glucocorticoid ‘stress’ hormones are directly responsible of the stress-induced alterations in telomere dynamics, (3) by which mechanisms (i.e. alterations of mitochondrial function, oxidative stress and DNA damage, impaired mTOR cellular signalling or telomere maintenance) stress exposure is accelerating telomere shortening, and if king penguin have specific mechanisms preventing/limiting stress-induced telomere shortening, and (4) if chronic stress / glucocorticoid hormones modify the acute oxidative stress responses of individuals. To this end, I will employ experimental approaches manipulating stress exposure and glucocorticoid hormones in captive Japanese quail and wild king penguins, and measure the resulting impact on telomere shortening and its potential cellular drivers (mitochondrial function, oxidative stress, mTOR cellular signalling). This project will enable a two-way transfer of skills and competences between the applicant and the host, by providing training to the applicant regarding mitochondrial biology, cellular signalling and gene expression, and by providing the host with the opportunity to integrate an ageing component through the use of telomeres in his current and future projects.

Keywords: telomere,mitochondria,oxidative stress,glucocorticoid hormone,bird