Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EcoD – Bringing new life to cod waste turning it into protein powder for human consumption (EcoD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With a global population growth from 7.3 billion to 9.7 billion by 2050, the protein demand is expected to double from the current 202 million tons/year. Protein sources are either animal- or plant-based and their production is depleting the environmental given their high water and land utilization as well as the large Green House Gas Emissions during production. Therefore, there is an urgent need for shifting the production of protein onto a more sustainable path. Iceland Protein (IS) is facing this challenge by developing EcoD, the first rich-protein powder for human consumption sourced from soft cod roes, a rest raw material (2% of cod volume) highly rich in essential and non-essential amino acids mainly discarded as food waste with only 8% utilized to produce low-value products not for human consumption. With EcoD we exploit fish waste, making it profitable and with a lesser impact on the environment adding value and turning it into a high-quality product for human consumption. Currently, most protein powders are sourced from cow’s milk protein such as whey and casein, eggs, or soy and peas. These products are banned for people with dietary restrictions (allergy and intolerance to dairy products, allergy to eggs or soy). EcoD is eligible this segment of people while providing the FAO/WHO recommended daily intake of essential amino acids and, in most cases, higher amino acid content than commercial alternatives. Furthermore, EcoD is especially beneficial for physically active individuals and elders thanks to its high glycine and arginine favoring muscle strengthening. Our product will be marketed via our well-established distributors and wholesalers (B2B) to bring EcoD until our targeted end-users. With this project (€1.5M additional investment) we seek to finalize the development of the EcoD and launch it across Europe by 2022 onwards, and later entering the US and Chinese markets. Doing it we will create 5 jobs and €7.5 M in revenues by 2026 (ROI 5. 5).

Keywords: soft cod roe,dietary restrictions,added value food products,protein rich powder,food waste management,aminoacids,proteins,nutrients
European Network Linking Informatics and Genomics of Helper T cells in Tissues (ENLIGHT-TENplus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Estonia,Germany,Germany,Finland,Switzerland,France,Netherlands,Netherlands,United Kingdom,Denmark,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 4067526.24
EU funding (EUR): 4067526.24
Participants: 16
Project status: SIGNED

ENLIGHT-TEN+ is a European Network Linking Informatics and Genomics of Helper T cells in Tissues: A crucial missing link in our current research environment is the lack of qualified individuals who possess the immunology skills to recognise and define important scientific questions amenable to -omics approaches, and also the bioinformatic expertise to interrogate and interpret the resulting Big Data appropriately. Thus, our mission is to provide cross-disciplinary training for a new generation of enthusiastic researchers who have in-depth understanding of T cell immunology and are also capable to handle large datasets. Our network of 15 beneficiaries from 10 European countries combines expertise on T cell biology with state-of-the-art technologies generating Big Data, cutting-edge bioinformatic tools including artificial intelligence, preclinical models and samples from patient cohorts. ENLIGHT-TEN+ will identify microenvironmental factors shaping the functional properties of tissue-resident T cells, which offer important therapeutic potential in various human autoimmune diseases, making them a key target for pharmaceutical companies. 15 early-stage researchers (ESRs) will be empowered to push our knowledge of tissue-resident T cells beyond the state-of-the-art which will enable the identification of novel biomarkers and support the development of advanced therapeutic concepts. The generation of Big Data is an emerging and challenging field, and there is high demand in both the academic and industrial sector for researchers to be able to analyse, integrate and exploit this rich source of information. ENLIGHT-TEN+ will combine individual strengths of innovative laboratories and enterprises from complementary disciplines to provide unique interdisciplinary training as an ideal stepping-stone for the ESRs to enter and strengthen Europe’s academia as well as pharmaceutical and bioinformatics companies, thereby placing them at the forefront of this emerging field.

Keywords: tissue resident t cells,big data,biomarkers,immune based therapeutic concepts
Horn and Crescent. Connections, Mobility and Exchange between the Horn of Africa and the Middle East in the Middle Ages (HORNEAST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-11-01
End date: 2023-12-31
Duration (months): 74.0
Total project cost (EUR): 1859656.0
EU funding (EUR): 1859656.0
Participants: 1
Project status: SIGNED

This project offers the first comprehensive study of medieval connections between the Horn of Africa and the Middle East in both Christian and Islamic contexts. It pursues the hypothesis that mobility and exchange along trade and pilgrimage routes, on both sides of and across the Red Sea, were not only vectors for the spread of Islam but also factors of African Christianities’ resiliency and reconfiguration at the same time. Medieval connections of Ethiopian and Nubian Christianities with other Eastern Christian churches have longer been studied than has been the spread of Islam across the Red Sea or along the Nile valley which remains poorly known. These parallel connections within Christen- and Islamdom across the same area have never been studied jointly, nor have been Christian-Muslim relations on such a scale. The project ultimately aims to reconnect the Horn of Africa to the global history of the area by connecting disjoint fields of research. It has the following objectives: • Providing a comprehensive survey of connections between the Horn of Africa and the Middle East (places, items, contexts) supported by a database and a geographic information system • Analyzing human mobility in the area within three critical configurations: pilgrimages (both Christian and Muslim), slave trade and slavery, metropolization (with the case study of Cairo) • Exploring cultural transfer and dissemination in the area within and between Christen- and Islamdom through the circulation of books, models and narratives • Evidencing regional connections and Christian-Muslim relations through archaeological survey at a very localised level: Nägaš (Ethiopia), a Muslim holy place in Christian environment related to the first exile (hijra) of Muḥammad’s companions This project is groundbreaking in rallying around the PI historians working on the area’s various realms in their several written languages, in both Christian and Islamic contexts, from the Arab conquest until the Ottoman one.

Keywords: connected history,cross cultural studies,christian muslim relations
Semi-Artificial Photosynthesis with Wired Enzymes (MatEnSAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2023-03-31
Duration (months): 78.0
Total project cost (EUR): 1960289.0
EU funding (EUR): 1960289.0
Participants: 1
Project status: SIGNED

Nature has been harnessing solar energy to drive endergonic life-sustaining reactions such as photosynthesis for billions of years. However, the overall biological processes are inefficient despite the evolution of efficient enzymes for carrying out specific reactions. Currently, there is an urgent need to develop superior strategies for the large scale conversion of solar energy into a renewable chemical fuel through artificial photosynthesis, which uses the same fundamental science as natural photosynthesis. Here we integrate the strengths of both natural and artificial photosynthesis to explore novel pathways for efficient solar-to-chemical conversion, which are otherwise inaccessible to either field alone. In aim 1, we develop advanced materials and strategies for the rational integration of photosynthetic enzymes into photoelectrochemical cells. A platform will be established in which enzymes can be artificially coupled to light absorbers, and also be wired together to perform novel chemical reactions. In aim 2, we adapt advanced analytical techniques, including scanning electrochemical microscopy and time-resolved spectroscopy, to gain mechanistic insights into the nature, extent, and mechanism of the enzyme-material interaction. This will aid rational cell design and shed light into reaction bottlenecks. In aim 3, we wire the enzyme-electrodes together in rational combinations to arrive at novel and efficient pathways for performing solar-to-fuel conversions. We will demonstrate the efficient coupling of solar energy harvesting with water oxidation and proton/carbon dioxide reduction. This integrated approach will lead the emergent field of semi-artificial photosynthesis beyond conventional solar fuels research. It will probe into the strengths and weaknesses of biological processes, and be used to explore how other processes (e.g. nitrogen fixation, C–H bond activation) can be more efficiently re-wired or be coupled to photochemistry.
Cork Discovers: Learn, Live, Love Research (Cork Discovers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-10-31
Duration (months): 18.0
Total project cost (EUR): 191650.0
EU funding (EUR): 191650.0
Participants: 4
Project status: CLOSED

We propose to host a Cork Discovers European Researchers Night (ERN) in 2018 and 2019 that will showcase research in fun, creative ways and will promote engagement between researchers and the public. The event will feature over 60 interactive events, with topics ranging from Archaeology to Zoology. Under the theme Learn, Live, Love Research (figure 1), Cork Discovers invites people to: • Learn about research and find out what it means to their lives; • Live like a researcher; visit laboratories and libraries, meet researchers and do experiments; • Love what research has to offer. Our consortium will bring ERN to Cork, Ireland, for the first time. Cork is Ireland’s largest county and has a population of over half-a-million people. It is home University College Cork (UCC), the project coordinator and largest University in the South of the Country. UCC sits in the heart of Cork and is ideally located to attract people from throughout the region. Its research strengths, as well as that of its consortium partner Teagasc, are closely linked to the local economy and community interests. This research will be the basis for a programme of outreach activities that are of relevance and interest to the local community forming 6 themes : Marine, Technology, Health, Agriculture & Food, Environment and Cultural Heritage. UCC and Teagasc will be supported in running the event by Cork City Council, the largest local authority in the region with extensive local knowledge and networks, and by UCC Academy Limited, a project management company with expertise in outreach and research communication. As 2018 is the European Year of Cultural Heritage (EYCH), a large section of the Cork Discovers programme will be dedicated to the topic and will encourage the people of Cork to discover and engage with their cultural heritage. We intend to apply for the EYCH label for the Cork Discovers ERN, an intention which has been very positively received by the Heritage Council of Ireland.

Keywords: research,outreach,communication,cultural heritage
Dynamic regulation of feeding behaviors in health and disease by top-down control of hypothalamic networks (FeedHypNet)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1875000.0
EU funding (EUR): 1473984.6
Participants: 2
Project status: SIGNED

Feeding behaviors represent a complex set of crucial for survival abilities required to meet upcoming nutritional demands. Eating disorders, such as anorexia nervosa, are widespread, difficult to treat and extremely dangerous, displaying the highest mortality rate of all psychiatric disorders and a very high relapse rate. Mechanisms of onset, progression and relapse of eating disorders are unknown. Feeding behaviors are regulated by hypothalamus, an evolutionary conservative brain region. While a role of neurochemically defined hypothalamic neurons in feeding has been recently studied, little is known about an adaptive regulation of hypothalamus by extrahypothalamic inputs. Further, it is not known how dynamic signaling in hypothalamus upon changing metabolic and environmental demands is organized to generate consistent adaptive behavior. The overarching goal of my proposal is to provide insight into neural mechanisms of healthy and pathological feeding behaviors. Combining optogenetics, electrophysiological recordings in transgenic behaving mice, Ca2+ imaging and fiber photometry, I will pursue 4 aims: (i) investigate role of neural circuitries that translate cognitive-related information to the lateral hypothalamus during adaptive feeding behaviors; (ii) characterize causal significance of top-down inputs from anxiety- and mood-related brain regions onto lateral hypothalamus in feeding, and study how changes in metabolic demands affect this signaling; (iii) study mechanisms and functions of fast, network oscillations-related and behavior-dependent signaling in hypothalamus; (iv) investigate how signaling in hypothalamus changes during development of anorexia nervosa symptoms and study consequences of optogenetically restored physiological signaling. This innovative and interdisciplinary approach will enable identification of neuronal circuits mediating feeding behavior in health and pathology, and thus gain insights into neuronal mechanisms of eating disorders.

Keywords: neuronal circuits,hypothalamus,prefrontal cortex,inhibition,neuropeptides,orexin,gaba,network oscillations,feeding,behaving mice,optogenetics,in vivo electrophysiology,eating disorders
PainDynamics: Research on the dynamics of attention bias for pain in daily life. (PainDynamics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Luxembourg
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Chronic pain is a major health care problem in Europe which results in huge economic costs. Available cognitive-affective accounts of pain, distress and disability suggest that attention plays a pivotal role in the development and maintenance of pain problems. In particular the presence of an attentional bias towards pain-related information (AB) is thought to initiate or exacerbate pain problems in chronic pain patients. Despite the intuitive appeal of this idea, findings are inconsistent. In the current project I argue that inconsistent findings in AB research are due to both conceptual and methodological limitations of previous research. From a conceptual standpoint, I argue that the presence of inconsistent findings is owe to the conceptualization of AB as a stable trait-like or habit-like process. Instead, I propose to conceptualize AB as a temporally dynamic, fluctuating and enfolding phenomenon that varies over time and across contexts. From a methodological standpoint, I furthermore argue that varying empirical support may also be due to limited ecological validity in AB research. I propose that the ecological validity could be increased by using somatosensory stimuli instead of linguistic stimuli and by investigating AB for pain-related information and key variables in everyday situations instead of in a single laboratory session. In the current proposal, I will address these conceptual and methodological challenges via (1) the development and validation of a novel ecologically valid paradigm to assess AB, and (2) an investigation of key hypotheses concerning the role of AB in chronic pain using a novel ecologically valid approach. Increased understanding of the occurrence, dynamics and implications of AB in varying daily life contexts represents an important step in advancing theoretical models on chronic pain. Furthermore, current findings may also help to attune clinical interventions to the needs of each individual pain patient.

Keywords: attention bias,chronic pain
AUTOMATION PACE (AUTOPACE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Spain,Italy,Serbia
Call: Automation in ATM (H2020-SESAR-2015-1, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 599867.5
EU funding (EUR): 599867.5
Participants: 5
Project status: CLOSED

Automation effects on arousal could be predicted differently depending on the Attentional Theory. The classical Theory (Kahneman, 1973) considers the level of arousal reliant only on psychological factors (stress, fatigue and emotions). Automation would only affect the task complexity by allocating part of the cognitive processing to the system. Alternative theories such as Malleable Attentional Resources Theory (MART) (Young and Stanton, 2002) assumes that automation would also affect the level of arousal and be dependent on controller´s expectations: when the ATCo expects that the task is easy in the near future, she/he will reduce the arousal levels and get bored or sleepy (overconfidence on automation). On the contrary, fears of automation failing would increase stress and also the level of arousal causing disorientation, overacting or erratic behaviour. Based on these theories, AUTOPACE proposes basic research on a Psychological Model to quantitatively predict how automation would impact on human performance based on cognitive resources modeling (demanded and available), tasks characteristics (automation), psychological factors modeling (fatigue, stress and emotions) and ATCo expectations (overconfidence vs fears of automation). A catalogue of training strategies to support the controller being “in-the-loop” will be explored. For the classical Theory, the strategies only for keeping attention on the main task avoiding out-of-the-loop effect. For the MART the coach will be also for coping with stress. A reviewed Curricula and ATCo Selection will be initiated. Expert Judgment from Psychologists, ATM Experts and Controllers Trainers supported by Literature Research will look at future competences and training strategies. The research on Psychological Modeling will be also sustained with Analytical Studies by using an existing prototype for demanded resources. AUTOPACE points at research paths suggested in “Ergonomics in design” Issue (Hancock et all, April 2013).

Keywords: automation,human factors,psychological model,competences,training