Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Mechanistic Modelling and Analysis of Large-scale Biomedical Data (INTEGRATE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1854546.0
EU funding (EUR): 1854546.0
Participants: 1
Project status: SIGNED

Modern cancer therapeutics target signalling processes within the cancer cells and the interaction of cancer and immune cells. A comprehensive understanding of these signalling processes is therefore essential to identify drug targets, plan clinical trials, and to select suitable drugs, drug combinations and drug dosages for a specific patient. Yet, most of the available mathematical models capture only a small number of molecular species and pathways, thereby ignoring important crosstalk and feedback loops. Furthermore, these models are usually based on experimental data for cell lines, which behave differently from complex cancer tissues. In INTEGRATE, I will develop computational methods for the full process of data-driven modelling of signalling processes in cancer, ranging from model development to parameterisation all the way to uncertainty analysis. To this end, I will combine methods from the fields of mathematical modelling, machine learning, and signal processing with established approaches in systems biology. The model development will employ natural language processing and an automatic testing framework. For federated model inference, I will develop scalable mini-batch optimisation and marginalisation based uncertainty quantification. To refine models, I will exploit tools from signal processing, such as blind identification of latent variables. I will apply the developed scalable mechanistic modelling approach to integrate large-scale biomedical data for molecular phenotyping studies and clinical trials across sites. This will provide mechanistic models reconciling the available data. The study will, for the first time, combine mechanistic modelling and machine learning for the integrated analysis of patient-derived omics and phenotypic data. By linking these data sources, INTEGRATE will deepen our understanding of biological signal processing and provide the basis for the development of digital twins.

Keywords: cellular signal processing,parameter estimation,statistical inference,uncertainty analysis,model selection
Single-fibre based holographic endoscope for observations of stroke in deep brain structure (StrokeGATE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Czechia
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-11-01
End date: 2024-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The origin project LIFEGATE introduced the prospect of multimode fibre based holographic endoscope as a unique tool for high-resolution in-vivo imaging of structures residing deep inside the brain of animal models. It harnesses the power of controlled light transport through hair-thin MMFs to image and measure brain functions at single cell and sub-cellular level in virtually any brain structure, at unlimited depth and in uniquely atraumatic manner, thereby unlocking a variety of opportunities when answering urgent bio-medical questions. The proposed ERC-PoC project StrokeGATE aims to utilise achievements of the origin project to introduce a novel, complete technological platform for investigating the impact of deep-brain stroke in living animal models. The geometry of the most advanced holographic endoscope currently built will be modified to allow induction of stroke of controlled magnitude, representing a powerful extension of the instrument’s applicability from the perspective of the users in neuroscience. Already available imaging capacity of the instrument will facilitate its navigation into the desired brain structure and, once the stroke is induced, monitoring changes to structural connectivity of the neurones within a circuit as well as development / suppression of signalling activity. LIFEGATE has already established a solid pathway to commercialisation through a start-up endeavour. Although intellectual property is expected to be generated during the execution of StrokeGATE, its main translational value lies in demonstrating the utility of MMF endoscopes across the relevant community of researchers who by now had only limited chances to fully appreciate the potential of such radically new and disruptive technological arrival. Successful accomplishment of StrokeGATE will unlock the exploitability of holographic endoscopy across a wider topical range of biomedical research, and reduce its translational barriers.
The transversal social impact of gold metallurgy in ancient societies: a diachronic approach from Prehistoric Iberia. (GOLDENIMPACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

GOLDENIMPACT aims to understand the social impact of gold technology implementation in all sectors of society and surpass outdated traditional narratives that solely understand gold as a consolidator of elite power. Hence, the project targets the study of gold production by 1) characterising existent technological traditions, 2) understanding the social consequences of metal cross-craft interactions affecting gold production, and 3) evaluating the extent and degree of novelty of the structural changes necessary to sustain gold production. Iberia was selected as case study (3100-1500 BC) for being an archaeologically rich area with an autochthonous development of metallurgy, and outside of the traditional research loci of ancient gold technology in Eurasia. To accomplish these objectives, this project uses a radically interdisciplinary methodology that combines knowledge from archaeology, anthropology and geology, with computational tools (R, QGIS) and materials science techniques (optical microscopy, pXRF, ICP-MS) to analyse selected gold items and deposits. As a result, it will be possible to reverse engineering and socially contextualise ancient gold production strategies and explore the links between technological and social change from a previously overlooked perspective (i.e. gold production). This will contribute to re-signify gold as a symbol of the achievements of non-elite people, and ultimately generate a more balanced narrative within the European history of technology, taking into account all society sectors and Europe’s Eastern periphery.

Keywords: iberia,chalcolithic,early bronze age,gold technology,gold provenance,social complexity,identities,cross craft interactions,technological traditions,optical microscopy,icp ms,pxrf
High Throughput Modelling and Measurement of Human Epithelial Models using Electrospun Conducting Polymers For Unlocking Data-Driven Drug Discovery (IMBIBE PoC II)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-06-01
End date: 2026-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Organ on Chip (OoC) technology, which models human tissues in vitro, is poised to refactor the drug discovery pipeline and alleviate the financial burden with the added benefit of reducing/ refining animal experimentation. The advent of non-destructive, biosensing modalities has placed data-driven approaches to identifying new therapeutics within reach, where highly parallelized instances of human organ models can be mined for AI and ML-augmented discovery. During our ERC CoG grant, we developed a novel technology which combines these two frontiers; by fabricating porous scaffolds from conducting polymer hydrogels, we were able to culture 3D organotypic models of human epithelial tissues, while conducting highly sensitive, non-destructive electrochemical monitoring of the tissues. During our previous IMBIBE PoC grant, we showed that our technology was compatible with a fluidic platform produced by an industry partner. However, in doing so, we identified a major pain point in the OoC ecosystem: the step discontinuity in the level of complexity, both of the tissue model and the typical OoC form factor, is too great to allow for integration into current industry workflows. This barrier to adoption is crippling and needs to be addressed by harmonising platform form factor with industry standards. Here, we propose pivoting our current technology to meet this need – by radically altering our fabrication methodology, opting for hydrogel electrospinning, we can produce simplified OoC platforms, which represent the smallest possible adoption cost to our industry partners, while providing for highly scalable continuous monitoring of the tissues. Further, our proposal will facilitate the process of gradual evolution of tissue model and sensor complexity, without disrupting industrial workflow, to allow convergence between the state of the art in the pharmaceutical ecosystem and the bleeding edge technological advancements being made in the academic sector.
Doctoral Programme for the Engineering of Complexity in the 21st Century (PhD_at_Tec21)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2026-01-01
End date: 2031-04-30
Duration (months): 64.0
Total project cost (EUR): 1663200.0
EU funding (EUR): 1663200.0
Participants: 1
Project status: SIGNED

The socio-economic challenges associated with the major industrial and environmental transitions of the 21th century require tackling engineering problems of increasing complexity. The PhD@Tec21 doctoral programme aims to train the next generation of experts in mechanical and process engineering. The trained fellows will become tomorrow’s leaders in strategic application areas such as environmental engineering, bio-engineering, sustainable energy, transportation, ecotech and cleantech, etc. The doctoral programme is supported by the LabEx Tec21, a well-established “Excellence Laboratory” in mechanical and process engineering at Univ. Grenoble Alpes (UGA). This will bring PhD@Tec21 unique advantages such as: (i) high-risk high-reward multidisciplinary scientific themes; (ii) cutting-edge research topics selected through an evaluation process by international experts; (iii) an extensive network of existing collaborators in both academia and industry, which will be exploited to offer secondment opportunities; (iv) highly qualified and experienced supervision teams; (v) access to state-of-the-art experimental and computing facilities. The training programme has been designed to equip the fellows with a comprehensive and balanced skillset. Mandatory secondments to international academic or industrial partners will provide further experience of the international and inter-sectoral dimensions. The acquisition of skills will be monitored through individualised Career Development Plans. Particular attention will be paid to recruitment and selection procedures carried out by external and independent experts, based on transparent criteria. Recruited fellows will be offered excellent working conditions, and will have the opportunity to pursue their project in one of the most beautiful university campuses in France.

Keywords: mechanical engineering,process engineering,bioengineering,research challenges,multi faceted training,socio economic applications,international environment
Is the succinate/SUCNR1 axis a fulcrum of cellular clocks? (CIRCASUC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Our circadian clock controls a wide range of physiological processes to respond to external demands through a fine-tuning coordination between the hypothalamic central clock and the peripheral clocks. Understanding the bidirectional communication and the reliance on external cues that specifically affect these clocks is of paramount importance. Yet, both circadian clocks can function even in the absence of these external signals, highlighting their endogenous nature. This underscores the existence of endogenous signals such as metabolites and other biomolecules that can modulate the circadian clocks. Surprisingly, this aspect remains largely unexplored in current research. Succinate is both an energetic metabolic product of mitochondrial activity and a byproduct of the microbiota, with critical physiological roles in cellular function at various levels. Furthermore, in the last years, succinate is emerging as a biomarker for early detection of metabolic dysfunction and cardiovascular risk. As a basis for the current proposal, we have recently reported, via an untargeted approach, that succinate regulates core-clock genes in adipocytes via its cognate receptor, SUCNR1. Thus, building upon our previous studies, we propose that succinate may serve as a pivotal endogenous signal capable of modulating the circadian clocks. Within the framework of this project, we present for the first time the concept of succinate as a link between metabolism and circadian clocks. To accomplish our goals, we will employ the complementary expertise between Dr Fernández-Veledo (supervisor and renowned expert in the succinate/SUCNR1 axis) and Dr Ribas (candidate and expert in chronobiology). By merging these two fields, we aim to integrate the notion of temporality into the succinate/SUCNR1 axis, and advance our understanding of the intricate relationship between metabolism and circadian rhythms.

Keywords: succinate,sucnr1,circadian rhythms,molecular clock,obesity,type 2 diabetes
Atmosphere Spectroscopy using Terahertz Sensors dedicated to quantum cascade laser sensing (AtSpecTS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Lithuania,United Kingdom,Germany
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 196976.16
EU funding (EUR): 196976.16
Participants: 3
Project status: SIGNED

The project AtSpecTS (Atmosphere Spectroscopy using Terahertz Sensors dedicated to quantum cascade laser sensing) aims o develop a compact, disruptive spectroscopic gas sensor technology for the 2–5 THz range, utilizing advanced field-effect transistor (FET) technology and offer QCL users a new compact and cost-effective solution for atmosphere research. Atmospheric gases like carbon dioxide, methane, nitrous oxide, and atomic oxygen are critical in greenhouse effects, chemical reactions, and energy regulation. Spectroscopy enables precise detection of these gases by analyzing their absorption and emission of electromagnetic radiation. The project focuses on improving the accuracy of gas detection and analysis in the terahertz range, where clearer signals with less spectral overlap can be obtained compared to IR spectroscopy. The expected outcome is a technology that is ready for participation in the next atmosphere research mission.

Keywords: terahertz,spectroscopy systems,atmosphere gas,absorbtion spectroscopy,optoelectronics
A game changing technology to revolutionise donor organ preservation and enlarge the pool of organs for transplantation (Vivalyx)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 3549117.14
EU funding (EUR): 2484382.0
Participants: 1
Project status: SIGNED

There are over 150,000 people on waiting lists for organ transplantation in Europe and the US today. Current transplantations cover less than 20% of the actual need, estimated at 1M organs by the WHO, due to the shortage of available transplantable organs. Predominantly used organ preservation methods fail at extending the pool of available organs. Perfusion at body temperature is the optimal organ preservation technology and it can expand the donor organ pool as it enables viability assessment and revitalisation before transplant. However, it is still underutilized in the clinical practice due to the requirement of blood, high costs and complexity of use, which makes it hardly scalable. Vivalyx has invented a game changing technology that unlocks the benefits of warm perfusion. This is Omnisol, a fully synthetic blood substitute solution that outperforms blood 3x in terms of organ viability and function during preservation. Vivalyx technology enables 3-4x organ pool expansion due to the organ resuscitation capabilities. Vivalyx was founded in 2022 by a group of scientists and medtech entrepreneurs with the vision of enabling all patients on transplant waiting lists to receive the organ they need. Through the EIC project Vivalyx will bring body temperature perfusion to the market, making this key technique of organ preservation scalable for the first time, creating tangible benefits for patients on transplant waiting lists.

Keywords: organ preservation,normothermic machine perfusion,warm perfusion
Universal Model of the Density of Deep Silicate Melts (Glass2Melt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1998856.25
EU funding (EUR): 1998856.0
Participants: 1
Project status: SIGNED

The starting conditions for the Earth’s evolution were set by gravitational differentiation in the solidifying magma ocean. Yet, a thorough understanding of the magma ocean dynamics and thus of the primordial Earth is lacking. One key unknown is the density of silicate melts at high pressure, which determines whether the crystallizing phases rise or sink. Magma density also governs the storage, spatial distribution, and migration of melts in the present-day Earth. Densities of silicate liquids at mantle pressures and temperatures are extremely difficult to measure because of the tiny sample size, melt chemical reactivity, and its lack of crystalline structure. The use of glasses as proxies of melts lifts some but not all of these challenges. Albeit needed for a holistic picture of planet Earth, no density systematics exists for glasses or melts across the pressure range of the entire mantle. Glass2Melt will employ and further a novel class of fast white laser spectroscopy methods to measure the density of multicomponent synthetic silicate glasses and melts at mantle pressure-temperature conditions. Our approach is ground-breaking because it allows to thoroughly explore a large compositional space and determine the density of any deep silicate melt. Our results will (i) parametrize a universal silicate melt density model applicable to the entire mantle, and (ii) quantify solid-liquid buoyancy throughout the whole crystallizing magma ocean. Glass2Melt will have a broad, lasting impact on our understanding of the Earth’s interior and its evolution over geologic time. The new density model will provide critical input for future numerical simulations assessing fundamental questions about the solidification of the primordial magma ocean, as well as the initiation and development of physical and chemical heterogeneity in the mantle. It will also be crucial for deciphering deep low seismic velocity structures, and to modeling magma dynamics in the present-day Earth.

Keywords: high pressure optical properties deep earth density diamond anvil cell laser heating glass melt refractive index