Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Efficiency and Effectiveness of Training for Teachers’ Pedagogical Digital Competence (EffecTive)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Estonia,Austria,Finland,Germany,Israel,Italy
Call: Efficiency and effectiveness of investment in high-quality education and training (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 2991750.0
EU funding (EUR): 2991750.0
Participants: 9
Project status: SIGNED

Many policy-level measures and programmes have been developed across the EU to support the integration of digital tools into teaching and support the students’ learning through a variety of interventions, mainly through investments in infrastructure, improved access to digital learning resources and providing teacher training on how to implement digital infrastructure in teaching and learning. Less attention has been paid to the impact of investments in teacher preparation and training on student learning and growing inequities have not been addressed. By conducting 12 quasi-experimental intervention studies across 5 EU countries, the EffecTive project tests effects of training conditions on teacher pedagogical digital competence, classroom practices and student learning outcomes and self-regulated learning skills to boost disadvantaged students. The project will contribute to the European knowledge base on the effectiveness and efficiency of teacher training programs, a methodology and toolkit for synthesizing costs and benefits across studies and a cost-efficiency analysis to assess and identify cost-effective policy measures for training. With active involvement of policy makers and teacher training institutions, the project will have wider implications for improving teacher training for the integration of digital technologies in schools, providing equal opportunities for all learners and leading Europe to a more

Keywords: professional digital competence,teacher training,self regulated learning
Drug DELIvery to the brain via CHOroid Plexus targeting (DeliChoP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1999756.0
EU funding (EUR): 1999756.0
Participants: 1
Project status: SIGNED

CNS disorders, e.g. brain cancer and Alzheimer’s disease, are the most common, debilitating, and underserved diseases. CNS drugs have historically suffered from considerably lower success rates during development than those for non-CNS indications. One of the major reasons is the presence of CNS barriers, including the blood-brain (BBB) and blood-cerebrospinal fluid (CSF) barrier. These blood-brain interfaces severely restrict the cerebral bioavailability of pharmaceutical compounds. While numerous attempts have been done to find methods to efficiently shuttle compounds over the BBB, less work has been done on blood-CSF crossers. Here, I hypothesize that targeting the blood-CSF barrier at the choroid plexus (ChP) is an attractive, innovative and underexplored strategy to deliver therapeutics to the brain. Indeed, this CNS barrier forms a unique interface between blood and CSF and delivery of therapeutics across the ChP epithelial cells may offer added-value for the treatment of CNS diseases. Recently, we could show that the blood-CSF barrier, via hijacking the FOLR1 pathway, is indeed a novel and exciting entry site to deliver therapeutics to the brain. Proof of concept data convincingly show that our in house generated anti-FOLR1 single domain antibody (VHH) is able to deliver a peptide into the brain. Undoubtfully, further validating the use of this VHH as brain shuttle could have major therapeutic implications. Here, I aim to investigate: (1) which cargos can be shuttled into (specific regions of) the brain, (2) which neurological disorders might be targeted and (3) whether other RMT targets at the blood-CSF barrier have similar brain targeting capacity. This project will finally reveal whether the blood-CSF barrier is an interesting entry route to the brain with therapeutic potential. Consequently, I infer that the data generated from this project may provide major impetus to the development of novel therapeutic strategies for the treatment of CNS diseases.

Keywords: brain delivery,blood csf barrier,choroid plexus,nanobodies
XR2ESILIENCE (XR2ESILIENCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Croatia,Germany,Portugal
Call: Resilience and mental wellbeing of the health and care workforce (HORIZON-HLTH-2023-CARE-04, 2023)
Start date: 2024-08-01
End date: 2028-07-31
Duration (months): 48.0
Total project cost (EUR): 5952178.75
EU funding (EUR): 5952178.75
Participants: 15
Project status: SIGNED

The health care system is in crisis and although the importance of nurses' mental health is widely recognized, achieving this goal is highly challenging. Promoting resilience in times of crisis appears to be a promising goal for public mental health. Innovative digital technologies to enhance resilience might contribute to a solution. Extended reality (XR) applications are highly immersive, interactive, and attractive to use. The proposed project aims to leverage the potential of XR to promote resilience in nursing staff. As resilience has a multitude of facets a prospective cohort study together with new analysis of existing large datasets will inform about those resilience factors that are the most promising target for interventions in nurses. Likewise, barriers and facilitators of acceptance of resilience training in general and XR-supported interventions in particular will be extensively considered and researched within this project. As acceptance through participation is a key success factor, a XR-supported training to foster resilience will be developed in close cooperation with nurses and other stakeholders. The proposed XR2ESILIENCE solution consists of a flexible selection of XR modules that can be customised to meet individual nurse needs. The efficacy of XR2ESILIENCE on stress coping and resilience will be investigated in a randomised controlled trial including a health economic evaluation. In addition, the project will go beyond the individual perspective and consider organisational and structural challenges. The cohort study will enable to identify working environments where nurses can grow and enfold their resilience. Based on the results, will develop a set of recommendations and checklists for employers and policymakers that support them in making nursing facilities resilience friendly places. XR2ESILIENCE outlines a strategy for building resilience and the role of XR in resilience training.

Keywords: resilience,extended reality,health care workers,nurses
Unravelling neuroimmune crosstalk to find novel treatment targets for inflammatory bowel disease (UNTANGLED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 432467.52
EU funding (EUR): 432467.52
Participants: 2
Project status: SIGNED

Up to 40% of patients with inflammatory bowel disease (IBD) do not respond to standard of care treatment with anti-inflammatory drugs. Unfortunately, the mechanisms driving persistent inflammation are unknown, resulting in a lack of specific therapies and an important burden for patients and society. Enteric neurons are highly specialized cells that sense and respond to nutrients, microbial products and inflammatory signals and densely innervate the gut. Besides regulating gastrointestinal motility, emerging studies indicate that crosstalk between enteric neurons and immune cells regulates inflammation, tissue homeostasis and antimicrobial immunity. However, this has not been investigated in the context of IBD. I hypothesize that enteric neurons become rewired during IBD and acquire an inflammatory signature that amplifies inflammation. Recent technological advancements will allow the investigation of enteric neurons via the use of cutting-edge tools in microfluidic droplet generation, molecular biology and functional genomics. We will leverage the Xavier lab’s expertise in the field of the enteric nervous system at the Broad Institute of MIT and Harvard during the outgoing phase, the expertise of Dr. D’Haens in IBD during the return phase at the Amsterdam University Medical Center and my expertise in pre-clinical IBD models in vitro and in vivo to characterize the role of enteric neurons in IBD for the first time and find potential treatment targets.

Keywords: ibd,inflammatory bowel disease,crohn s disease,ulcerative colitis,enteric nervous system,enteric neurons,gastroenterology
Piezomagnetic ferrites for self-biased non-reciprocal millimeter wave devices (Pi4NoRM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The relentless demand to increase data rates, traffic, and connected devices in our mobile communications has prompted a paradigm shift in wireless technology. 5G and the forthcoming 6G will use mm-waves and miniaturized antenna systems that need to be low-cost and energetically efficient. An unresolved challenge of this transition is the miniaturization of non-reciprocal devices above 100 GHz. Pi4NoRM envisions an on-chip integration of miniaturized self-biased non-reciprocal magnetic components for the forecasted 6G evolution. Those passive devices are significant components fulfilling three critical functions within RF systems: decoupling amplifiers, protecting the systems against mismatched impedances or electromagnetic aggression and enabling the Full-Duplex operation of antennas. Pi4NorM aims to fill the gap between materials science and mm-wave engineering to develop sub-THz, ultra-compact, self-biased non-reciprocal elements. The success of Pi4NoRM could open an expansive innovation roadmap toward more capable RF systems and radar. For this reason, a strategic transfer strategy is also implemented in Pi4NoRM.
Sustainable Decentralised Storage: Integrated Perovskite Solar Cells-Zinc Quasi-Solid Batteries (PSC-ZB) (PSC-ZB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 2
Project status: SIGNED

Self-powered integrated solar rechargeable batteries are becoming a safe and practical solution for power backup in remote areas, disaster zones and inconsistent sunlight regions. The high indoor energy conversion efficiency perovskite solar cells (PSCs) and non-explosive quasi-solid zinc batteries (ZBs) are promising options for next generation energy conversion and storage devices. Novel ZBs offer high-energy, leak-proof safety, cost-effectiveness, and environmental friendliness, making them superior to the explosive Li-ion batteries (LiBs). Solar rechargeable ZBs (PSC-ZB) can effectively generate and store solar energy in a two-electrode battery, simplifying the design and minimising external energy loss. However, several major challenges hinder the mass adoption of PSC-ZB: (i) low efficient common photoactive cathode, and (ii) destabilisation and short cycle life caused by side reactions on Zn anode. Firstly, the proposal involves a initiated chemical vapor deposition (iCVD) process to develop compact, fully lead-closed PSC-ZB with a cathode via bifunctional heterojunction concept (BCH). This design incorporates a safe-by-design self-power supply unit that enables immediate storage of solar-to-electrochemical energy. The MXene-encapsulated cathode, developed using the Stöber method, and the dendrite-free anode, improved with Na+ electrolyte additives and protective coatings can significantly enhance the cycling stability and energy efficiency of PSC-ZBs. The main goal of PSC-ZB is to boost efficiency (>12%) and stability by increasing active sites, shortening diffusion pathways, and enhancing anode plating and stripping cycles. Achieving PSC-ZB goals would advance state-of-the-art direct solar-to-electrochemical batteries in a simple two-electrode format, crucial for meeting EU environmental targets for a cost-effective and eco-friendly energy system. This fellowship offers an excellent opportunity to achieve long-term career goals and expand my knowledge.

Keywords: solar batteries,perovskite solar cells,zinc ion batteries,2d mxenes,st ber process,initiated chemical vapor deposition icvd
The Immunological Puzzle of Atlantic Cod: Thriving Without MHC II (NoMCod)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-11
End date: 2027-08-10
Duration (months): 24.0
Total project cost (EUR): 267418.56
EU funding (EUR): 267418.56
Participants: 1
Project status: SIGNED

Title: The Immunological Puzzle of Atlantic Cod: Thriving Without MHC II Francisellosis is a bacterial infection caused by Francisella noatunensis subsp noatunensis (F.n.n) in teleosts such as Atlantic cod (Gadus morhua). These vulnerable Atlantic cods are crucial for sustainability of the North Atlantic ecosystem and fisheries. The disease is generally manifested as granulomatous lesions in head, kidney, liver, gills, heart and spleen. At present, its treatment is a major challenges for commercial fisheries sectors with the current availability of only antibacterial drugs with limited efficacy and no licensed vaccine available for the fish, so far. Genome sequencing of Atlantic cod revealed lack of otherwise well conserved among other vertebrates, the major histocompatibility complex (MHC) class II immune pathway due to gene losses of MHC II, CD4 and invariant chain (Ii) and presence of an expanded MHC I and toll-like receptor (TLR) repertoire. Little is known for the compensatory mechanisms governing immune responses against infections in the cod, in the absence of MHC II. We aim to determine the functions of MHC I and TLRs and mechanisms of antigen presentation and immune responses to bacterial infection in the cod fish with 2 objectives 1) characterization of MHCs and TLRs using teleosts as model systems b) identify the mechanisms of bacterial infection involving MHCs and TLRs. The methodologies involve culturing of wild caught Atlantic cod derived primary macrophages and cell lines, transfection with fluorescently labelled MHCs and TLRs, microscopy (live-cell imaging, super-resolution microscopy), RUSH assays, mass spectrometry, pull down assays, transcriptomics to elucidate the role of different MHC I and TLRs in response to F.n.n infection. This will enable us to delineate expanded roles of MHC I and TLRs and provide a platform to develop effective antibacterial therapeutic strategies against F.n.n infection in Atlantic cods.

Keywords: atlantic cod gadus morhua,mhc i,tlrs,antigen presentation,francisellosis,francisella tularensis
A Comprehensive Translational Research and Training Pipeline Harnessing Lipid Metabolism to Improve Prostate Cancer Management and Educate Young Researchers in Tackling Complex Disease (PROSTAMET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,France,Italy,Portugal,United Kingdom,Germany
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2398219.2
EU funding (EUR): 2398219.2
Participants: 17
Project status: SIGNED

PROSTAMET is an immersive Doctoral Network (DN), that aims to train the next generation of researchers tackling complex multifactorial diseases, including cancer, that are typically characterized by an outspoken inter- and intra-patient heterogeneity and that increasingly face our ageing society. Despite unprecedented technological advances to dissect disease into its smallest details, the translation into cost-effective and personalised treatment approaches is one of the timeliest challenges that face the scientific community and that require a specific transdisciplinary mindset and education. Focusing on prostate cancer as a key paradigm of such a complex disease and as one of European Health Union’s new focus areas for organised screening, PROSTAMET aims to bridge current gaps in translational research, capitalising on the underexplored clinical potential of altered lipid metabolism in cancer. Through a close collaboration among well-selected academic and non-academic partners with highly complementary expertise, PROSTAMET aims to set up a unique lipid-focused translational research pipeline from cutting-edge spatially-resolved molecular discovery, through validation in gold-standard models, all the way to innovative drug development. Through its modular and bidirectional nature with multiple entry points, this pipeline is expected to generate outputs at multiple levels of the drug development chain for sustainable downstream valorisation. Through a combination of high-level technological “hands-on” research, non-academic placements and courses/workshops on scientific and complementary “soft” skills facilitated by the academic/non-academic composition of the consortium, PROSTAMET’s ambition is to provide young researchers with a creative and holistic view on translational research along with strong transferable skills to prepare them to take up thriving careers in a transformative health care system focusing on personalised precision medicine.

Keywords: lipids,lipidomic,drug development,prostate cancer,multiomics
Information Economics for Science (InfoEcoScience)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1461050.0
EU funding (EUR): 1461050.0
Participants: 1
Project status: SIGNED

Given the uncertainty shrouding even the most promising research projects, information plays a key role in the organization of science. The project develops foundational tools in the organizational economics oGiven the uncertainty shrouding even the most promising research projects, information plays a key role in the organization of science. The project develops foundational tools in the organizational economics of science, through two inter-linked packages: I. Comparing Information Researchers select questions to work on, choose sites for testing, and trim samples when analysing data. Editors select referees from a pool of potential reviewers. This package develops a general approach for comparing information structures, such as the selected experiments described above, for decision problems with certain properties. Once decision problems are restricted to a class satisfying properties such as monotonicity, more information structures can be compared than in Blackwell’s classic approach. The proposal presents some ideas for developing general characterization results and for applying the new method to the comparison of experiments produced in a social context. II. Supporting Science This package develops a framework for the design of science subsidy schemes with imperfect verification. Researchers have some noisy information about the chances of success of their project and go through a costly selection process. Research proposals are evaluated by reviewers with imperfect expertise. The aim is to characterize the optimal mix of push and pull incentives for financing knowledge creation and aligning researchers incentives with social objectives. A subproject develops a structural methodology for estimating research funding models and applies the method to a unique dataset from the Research Council of Norway (RCN) covering all fields of research and containing detailed information about applicants (whether they are awarded a grant or not) as well as evaluators.

Keywords: information,evaluation,selection,research bias,research funding