Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel properties of antigen receptors and instruments to modulate lymphoid function in physiological and pathological conditions (NOVARIPP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Spain
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-02-01
End date: 2019-07-31
Duration (months): 66.0
Total project cost (EUR): 2491827.0
EU funding (EUR): 2491827.0
Participants: 1
Project status: CLOSED

The current paradigm of T cell function in the immune response is that T cells recognize antigen through the T cell antigen receptor (TCR) which transduces signals to the cytoplasm by way of cytosolic priming and effector tyrosine kinases. The TCR acts in a monovalent fashion is crosslinked by its antigen/MHC (pMHC) ligand, causing TCR triggering. However, our more recent data indicate that the TCR is organized in pre-existing oligomers, and therefore it might not require crosslinking, and that the triggered TCR adopts, upon ligand binding, an active conformation that is responsible for recruiting cytoplasmic effector molecules. We have found novel direct effectors of the TCR, including the Ras GTPase TC21 and unveiled that these effectors play an essential role in a variety of TCR signaling functions including tonic signaling and TCR downregulation. Furthermore, we have found that TC21 is required for the acquisition of pMHC by T cells from the APCs and re-express it on their own plasma membrane, becoming themselves APCs for other T cells. In this proposal we wish to explore several of the avenues open by our most recent findings, including the importance of pMHC presentation by T cells. Another objective is to study an interesting property of the conformational change in the TCR: its return to the inactive conformation even when it is still bound to its pMHC ligand (countdown effect). We also propose to use approaches that alter the size of pre-existing TCR oligomers to seek for new ways of modulating T cell activation. The last two objectives refer to study the role of TC21 as a direct effector of the B cell antigen receptor (BCR). We propose to study the involvement of TC21 in the B cell germinal center response and how the deregulation of its expression can influence the transformation of GC B cells into lymphomas. Finally, we propose to generate small molecular weight inhibitors of TC21 as potential drugs for the treatment of lymphomas.
Commercialization and Public Dissemination of LIBPR Research Results (LIBPRPOC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Israel
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-03-01
End date: 2014-02-28
Duration (months): 12.0
Total project cost (EUR): 168224.4
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Behavioral programming (BP), which is a direct outcome of the current LIBPR ERC grant, is a novel, language-independent development paradigm, centered around natural and incremental specification of behavior. It is currently implemented in multiple programming languages. BP allows building software applications from independent scenarios, each corresponding to an individual requirement. The paradigm is supported by tools for fully executing the specification, and for debugging, execution planning, learning-based adaptivity, model-checking for detection of conflicting and incomplete requirements, and automatic repair of problems and conflicts. BP has the potential of allowing complex systems to be developed by large groups of individuals, and subsequently to be maintained by different individuals, substantially reducing the need to understand the intricacies of already-existing code when implementing new requirements. This accelerates development and reduces costs. In the proposed POC project we plan to (a) make all the source code freely available to the public (b) develop rich example applications that help demonstrate and prove the benefits of BP concepts in a broad spectrum of real-world applications (c) upgrade our tools via bug repair and functional enhancements for broad usability of the proof-of-concept. These actions will allow potential end-users to directly benefit from our research deliverables, and enable commercial companies, professional communities and individuals, to use the research results as a basis for developing commercial and free products.

Keywords: 227631
Core/Shell nanoparticle electrocatalysts for fuel cell applications: probing the market potential of Atomic Layer Deposition (ALD) coatings (CONIA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-05-01
End date: 2014-10-31
Duration (months): 18.0
Total project cost (EUR): 147872.0
EU funding (EUR): 147872.0
Participants: 1
Project status: CLOSED

Fuel cell systems are high-efficiency, low-emission energy conversion modules for transportation, stationary and portable applications. Especially for automotive applications, low-temperature proton exchange membrane (PEM) fuel cells are considered a key-stone solution, as they can effectively reduce greenhouse gases emissions. A major barrier for the market penetration of these systems is the material scarcity of precious metals used for the fabrication of the electrocatalyst, a core-component of the system. Achieving increased performance in terms of catalytic activity and stability (corrosion resistance) while decreasing the cost, can be realized by a drastic redesign of the catalyst fabrication process using Atomic Layer Deposition (ALD) of nanoparticles. Using the understanding of the ALD coating processes obtained in the ERC-StG project AggloNanoCoat, the technique’s potential for producing tailored yet inexpensive core/shell nanoparticles for advanced catalysis applications has been identified. The innovative process characteristics (precise surface modification, mild operating conditions, scale-up potential and minimization of environmental footprint) clearly form a strong pre-commercialization starting-point. The next required step is the assessment of the market potential, effectively bridging nanoparticle ALD and the fuel cell catalyst manufacturing section. The CONiA project will establish the basis for commercial development by introducing an attractive communication package based on the outcomes of a validation case-study. The main objective of the activities will be to demonstrate the scale-up potential and provide an initial costing structure for the future venture. In parallel, a solid business proposition will be set, to enable the consecutive required actions for securing further funding and to provide the corner-stone for kick-starting a company that will commercialize the technology.

Keywords: 279632
Early-stage tumour markers based on the Flower proteins (FLOWERFIELDS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Switzerland
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-02-01
End date: 2014-01-31
Duration (months): 12.0
Total project cost (EUR): 154800.0
EU funding (EUR): 138030.0
Participants: 1
Project status: CLOSED

It is unquestioned that early detection of cancer is a major factor contributing to therapy outcome. Unfortunately, only few tumour markers have been identified for early stage cancers to date, and the reliable detection of tumours before the manifestation of morphological changes still remains an unresolved problem in routine clinical diagnosis. A recent study came to the conclusion that shedding rates of currently available cancer biomarkers are a factor of 10-4 below the necessary sensitivity to reliably detect cancers during their first decade. In other studies, the reliability of currently existing biomarkers such as the PSA-marker for prostate cancer is questioned. The development of alternative early-stage tumour markers, in particular also for epithelial cancers, is therefore urgently necessary. FLOWERFIELDS is aimed to provide means and methods to detect such cancer cells before an aggressive tumour is formed. To that end, we plan to exploit the extracellular molecular code called “The Flower Code” (Fwe) that is expressed in very early stage cancer or precancerous cells. Fwe may be integrated into routine immuno- or PCR-assays for the detection of a variety of epithelial cancers. Applications may include early-stage diagnosis but also the evaluation of therapy outcome. The current project has two aims: (i) to develop improved ligands for ELISA diagnostic tests for Flower gene expression, (ii) to validate the concept clinically on human samples in both immuno- and PCR-based assays. The clinical validation of a biomarker candidate is a key success factor for being able to feed it into development stage of a commercial partner.

Keywords: 200130
Droplet-based chips for biologists (DROPCHIPS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: France
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-06-01
End date: 2014-05-31
Duration (months): 12.0
Total project cost (EUR): 168224.4
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The aim is to develop microfluidic droplet-based tools for biological research and diagnostics applications. The devices will be based on advanced droplet manipulation schemes, which allow the high-throughput production of droplets, maintaining them fixed, and observing their contents.

Keywords: 278248
Highly selective customizable therapy for metastatic tumors (CANSEL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Switzerland
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-07-01
End date: 2014-12-31
Duration (months): 18.0
Total project cost (EUR): 165840.0
EU funding (EUR): 149499.0
Participants: 1
Project status: CLOSED

The ERC starting grant CellControl awarded to the Principal Investigator Yaakov Benenson funds research directed toward rational design and construction of gene circuits and networks for programmable control of cell physiology. One of the potential applications of this research is in the development of next-generation anticancer treatments that incorporate recently acquired knowledge on the complexity of cancer-related regulatory pathways, tumor development and differentiation, and the rise of cancer clones resistant to standard therapies. These new treatments are necessarily more complex than small molecule drugs, yet they are within reach of latest tools developed in gene therapy and they hold the promise of much higher efficacy and lower toxicity as well as robustness to the emergence of resistant clones. Thus our approach could be of great potential for treating metastatic and primary malignant tumors. We have already shown an engineered circuit that selectively detects and eliminates specific cancer cells in vitro. Powered by additional developments in the framework of the ERC starting grant, we have designed an even safer and more selective circuit that can serve as a starting point for pre-clinical and eventually clinical testing. In this proposal we describe proof-of-concept experiments that will show feasibility of our approach in a mouse model. Successful demonstration will pave the way to large-scale translational R&D financed by private investors, and eventually to the deployment of these new therapies in the clinic.

Keywords: 281490
Therapeutic Applications of Light-Regulated Drugs (THERALIGHT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Spain
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-08-01
End date: 2014-11-30
Duration (months): 16.0
Total project cost (EUR): 160900.0
EU funding (EUR): 149915.0
Participants: 1
Project status: CLOSED

One of the major drawbacks of pharmacological therapies is the difficulty to control drug kinetics and restrict drug action to the target organ. This in turn limits the efficacy of drugs and triggers undesired side effects for patients. We have developed an innovative approach to control the activity of drugs with light in cell culture systems. The PoC grant will allow going a step further by testing these new methods on important pharmacological target receptors and assay them in vivo. These tests should lead to the first clinical trials and to present the biomedical applications of his project to pharmaceutical companies. The combination of drugs with external illumination devices could create a more personalised medicine where therapies could be tuned to adapt each individual patient.

Keywords: 210355
Novel low cost catalyst for direct hydrogen peroxide synthesis (LOWCOSTPEROXIDE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-04-01
End date: 2014-03-31
Duration (months): 12.0
Total project cost (EUR): 166372.8
EU funding (EUR): 149506.73
Participants: 1
Project status: CLOSED

The discovery of the catalytic properties of gold has advanced understanding of the fundamental properties of catalyst materials and has opened new avenues for catalyst design and reaction control. However, the price of gold is a significant barrier to commercial uptake and implementation. A discovery arising from the ERC Advanced grant ‘After the Goldrush’ (ERC-2011-AdG-291319) offers the prospect of a new generation of catalyst materials that have all the beneficial features of gold-based catalysts, but utilising much cheaper metals. The proposed programme (LOWCOSTPEROXIDE) will bring to pre-commercial stage a selective, efficient and cost-effective catalyst system for the direct synthesis of the valuable commodity chemical, hydrogen peroxide, from hydrogen and oxygen.

Keywords: 291319
PulsarPlane: Worldwide Air Transport Operations (PULSARPLANE)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Aeronautics and air transport
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Finland,Portugal,Bulgaria,Netherlands
Call:  (FP7-AAT-2012-RTD-L0, 2012)
Start date: 2013-09-01
End date: 2015-05-31
Duration (months): 21.0
Total project cost (EUR): 775304.0
EU funding (EUR): 596652.0
Participants: 6
Project status: CLOSED

Pulsars are fast rotating neutron stars that emit electromagnetic radiation, which is received on earth as a series of very stable fast periodic pulses with periods in between 1.4 milliseconds and 8.5 seconds. These periodic pulses and the known positions (in celestial coordinates) of the neutron stars make them ideal beacons for navigation. Air traffic management and aircraft operations are currently dependent on the use of ground-based navigation systems. Still, many areas on earth are not equipped with this kind of infrastructure. In oceanic flights and isolated areas, aircraft fly procedural tracks assisted by inertial navigation and/or GPS. as no ground equipment is available to guide them along their tracks. We propose a new navigation system, based on the signals received from pulsars. Pulsar navigation enables a means of navigation without the need for ground-based or space-based equipment. If pulsar navigation is feasible, at least 5 advantages are identified for aviation 1 Overcome GNSS vulnerabilities 2 Reducing operational cost of air transport 3 Contribute to greener transport by enabling secure formation flying of commercial airplanes in oceanic and remote areas 4 improve flexibility and accessibility of air transport 5 Contribute to a common reference time frame for aviation The objective of this study to investigate the feasibility of pulsar navigation for aviation, and if found positive, to analyse the impact on aviation and to identify and develop (sections of) the path towards a useable real-time navigation and timing system.

Keywords: navigation
Invariant manifolds in dynamical systems and PDE (INVARIANT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Spain
Call:  (ERC-2013-StG, 2013)
Start date: 2014-01-01
End date: 2019-06-30
Duration (months): 66.0
Total project cost (EUR): 1260041.87
EU funding (EUR): 1260041.87
Participants: 1
Project status: CLOSED

The goal of this project is to develop new techniques combining tools from dynamical systems, analysis and differential geometry to study the existence and properties of invariant manifolds arising from solutions to differential equations. These structures are relevant in the study of the qualitative properties of ODE and PDE and appear very naturally in important questions of mathematical physics. This proposal can be divided in three blocks: the study of periodic orbits and related dynamical structures of vector fields which are solutions to the Euler, Navier-Stokes or Magnetohydrodynamics equations (in the spirit of what is called topological fluid mechanics); the analysis of critical points and level sets of functions which are solutions to some elliptic or parabolic problems (e.g. eigenfunctions of the Laplacian or Green's functions); a very novel approach based on the nodal sets of a PDE to study the limit cycles of planar vector fields. With the introduction by the Principal Investigator, in collaboration with A. Enciso, of totally new techniques to prove the existence of solutions with prescribed invariant sets for a wide range of PDE, it is now possible to approach these apparently unrelated problems using the same strategy: the construction of local solutions with robust invariant sets and the subsequent uniform approximation by global solutions. Our recent proof of a well known conjecture in topological fluid mechanics, which was popularized by the works of Arnold and Moffatt in the 1960's, illustrates the power of this method. In this project, I intend to delve into and extend the pioneering techniques that we have developed to go significantly beyond the state of the art in some long-standing open problems on invariant manifolds posed by Ulam, Arnold and Yau, among others. This project will allow me to establish an internationally recognized research group in this area at the Instituto de Ciencias Matemáticas (ICMAT) in Madrid.

Keywords: periodic orbit,critical point,level set,knot,eigenfunction,integrating factor,stability theorem,global approximation theorem,topological fluid mechanics.
Beyond Enemy Lines: Literature and Film in the British and American Zones of Occupied Germany, 1945-1949 (BEYONDENEMYLINES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Cultures and cultural production
Countries involved: United Kingdom
Call:  (ERC-2013-StG, 2013)
Start date: 2013-09-01
End date: 2020-02-29
Duration (months): 78.0
Total project cost (EUR): 1414601.0
EU funding (EUR): 1414601.0
Participants: 1
Project status: CLOSED

This project investigates the cross-fertilisation of Anglo/American and German literature and film during the Allied Occupation of Germany. It will be the first study to survey the cultural landscape of the British and American zones of Occupied Germany in any detail. By doing so it will offer a new interpretative framework for postwar culture, in particular in three areas: the history of the Allied Occupation of Germany; the history of postwar Anglophone and Germanophone literature (arguing the two were more intertwined than has previously been suggested); and the history of the relationship between postwar and Cold War. Combining Anglo-American and German literature and film history with critical analysis, cultural history and life-writing, this is a necessarily ambitious, multidisciplinary study which will open up a major new field of research.

Keywords: film,war,reconstruction,cultural exchange,colonialism
Exploring Strongly Correlated Quantum Matter with Cold Excited Atoms (ESCQUMA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: United Kingdom
Call:  (ERC-2013-StG, 2013)
Start date: 2014-01-01
End date: 2019-06-30
Duration (months): 66.0
Total project cost (EUR): 1492000.0
EU funding (EUR): 1492000.0
Participants: 1
Project status: CLOSED

The understanding of quantum matter in and out of equilibrium is among the biggest challenges of modern physics. Despite decades of research fundamental questions, such as the precise workings behind rather ubiquitous materials such as high temperature superconductors are still unresolved. At the same time there is a new generation of experiments approaching which realises and probes quantum matter with novel and exotic interactions at an unprecedented level of precision. This has already highlighted new avenues of research but also demands for radically new theoretical approaches which lie outside the scope of just a single traditional physical discipline. Novel and in particular multidisciplinary lines of thinking are required to tackle this immense challenge. Such new research will not solely be delivering invaluable insights into currently unresolved problems but rather form a new basis for the understanding of quantum matter from a multidisciplinary perspective. This will open up new horizons for fundamental research and at the same time will pave the way for future technologies and materials which rely on non-equilibrium phenomena or quantum matter. This research proposal takes on this challenge by setting up a broad theoretical research programme which is multipronged and multidisciplinary and which directly connects to the most recent research efforts in ultra cold atomic physics. Here currently a step change is taking place where new experiments explore strongly correlated quantum physics within gases of excited atoms – so-called Rydberg atoms. Exploiting this unique moment we will develop a framework for the description of the equilibrium and non-equilibrium properties of these complex and very versatile quantum systems. This system-specific research approach has the advantage that theoretical predictions can be verified experimentally and applied in practice almost immediately, leading to research attacking the frontiers of current knowledge.

Keywords: rydberg atoms,non-equilibrium,open quantum systems