Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Building a Protein Sequence Library using Nanopores (NPSL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Nanopore is a breakthrough genomic sequencing tool with long read length, high accuracy, and high throughput in reading DNA. However, it is the proteome that ultimately determines the cell’s phenotype, and tremendous efforts have been made to develop sequencing techniques for reading proteins in the past decade. First breakthroughs have been appearing for sequencing short peptides at the single-molecule level. Current strategies are however still far from sequencing full-length native proteins due to the low synthesis efficiencies in protein handling and the limited scanning length (can only read short peptides with ~25 amino acids). Here, I will first develop a novel method to synthesize a large variety of proteins that are connected to DNA with their own codon sequences, using just a few reactions with a puromycin linker labeled to a mRNA, and followed by in vitro translation, reverse transcription, and RNase cleavage. Furthermore, I propose a single-molecule protein nanopore engineering strategy that significantly extends the MspA nanopore lumen length to push the limit for protein reading length. With the proven abilities of a Hel308 DNA helicase, the engineered nanopore can read the entire DNA codons first, followed by the read of >100 amino acids of the protein. Upon recording large data sets, I will build a protein signal library with the related codon information for the training of a machine learning model, which serves as a tool for de novo protein sequencing. This work has great potential to push the limits of sequencing technology to reading the whole proteome.

Keywords: nanopore,protein sequencing
Optimizing the delivery and uptake of malaria vaccines in countries with areas of highly seasonal transmission in West and Central Africa (OPT-MVAC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Luxembourg,Senegal,Switzerland,Morocco,United Kingdom,Germany
Call: Improving modes of delivery, deployment, and uptake of vaccines through phase IV/implementation research (HORIZON-JU-GH-EDCTP3-2023-02-two-stage, 2023)
Start date: 2025-01-01
End date: 2029-06-30
Duration (months): 54.0
Total project cost (EUR): 5297181.25
EU funding (EUR): 5297181.25
Participants: 8
Project status: SIGNED

The availability of effective malaria vaccines is a historic landmark, “a breakthrough for science, child health and malaria control” that “could save tens of thousands of young lives each year” [WHO 2021]. But substantial implementation challenges need to be addressed to realise this potential. In many areas where malaria vaccines will soon be introduced, EPI coverage is suboptimal, especially in the second year of life. Introduction of malaria vaccines is also an opportunity to strengthen delivery of basic vaccines because a) additional immunisation visits will be required to administer 3 doses of malaria vaccine between the ages of 5 and 9 months and a fourth dose at about 2 years, and b) in areas with highly seasonal malaria, annual intensification of vaccine delivery may be advantageous to optimize malaria impact, both providing opportunities for catch-up of other vaccines, and c) recognition of the importance of malaria may lead to be less mistrust of malaria vaccines, as observed during pilot implementations; such positive attitudes could be leveraged to promote vaccination in general. The purpose of this project is to support national immunization and malaria programmes in 14 countries in West and Central Africa with highly seasonal malaria, to optimize delivery and uptake of malaria vaccines, and to exploit the opportunities to strengthen delivery of other vaccines. This will be achieved through a programme of implementation research, adapting delivery approaches to local situations, and sharing information about what works best. The project, which builds on a network of 13 countries that was established through the EDCTP-funded OPT-SMC project, coordinated by the University of Thiès in Senegal, the LIH, TDR, LSHTM, CAPM, MMV and WHO, will provide grants and technical assistance to national programmes to enable them to monitor vaccine introduction and identify barriers to uptake, and develop, implement, and evaluate strategies to address these barriers.

Keywords: immunisation programmes,malaria,vaccine delivery
Resilient Carbon Negative Geoenvironmental Engineering (RECANGEE) (RECANGEE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Switzerland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 1800000.0
EU funding (EUR): 1800000.0
Participants: 1
Project status: CLOSED

RECANGEE: Resilient Carbon Negative Geoenvironmental Engineering RECANGEE builds on Medusoil’s momentum in scaling bio-cementation technologies across Europe, targeting critical applications in ground reinforcement, flood defence, and soil restoration. The project is poised for EU-wide market deployment, with strong industrial traction demonstrated through NDAs and pilot engagements with major infrastructure players and public agencies across at least five member states, including France, the Netherlands, Italy, Greece and Austria. A fully owned subsidiary in Belgium anchors regional operations and accelerates commercialization, reinforcing Medusoil’s European presence. Over the past two years, the company has secured key patents focused on circular production, CO2 mineralisation, contaminant encapsulation, and the valorisation of industrial by-products. These innovations underpin a new class of low-carbon, regenerative binders that offer a scalable response to soil devolution, land contamination, and climate-driven hydraulic threats. Aligned with the European Green Deal and national resilience agendas position Medusoil as a leading provider of climate-adaptive materials and technologies for infrastructure renewal across Europe.

Keywords: sustainable construction materials ground stabilization and erosion control circular infrastructure solutions low carbon geotechnical applications industrial scale biocement production
Digital Hate: Perpetrators, Audiences, and (Dis)Empowered Targets (DIGIHATE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2499591.25
EU funding (EUR): 2499591.0
Participants: 1
Project status: SIGNED

The skyrocketing rise of digital hate can be considered the dark side of the democratizing power of the internet. Despite growing interest in the topic, there has never been a systematic investigation about the perpetrators, audiences, and targets of digital hate. To discover why digital hate emerges, why it is often tolerated, and what kind of effects it has, DIGIHATE will analyze the reasons, perceptions, and consequences of digital hate for all involved actors. In particular, DIGIHATE will cause a paradigm shift by systematically looking at both disempowered and empowered targets of digital hate as well as their complex intersections. Nine work packages (WPs) will form a unique multidisciplinary, multi-language, mixed-method approach, including computational analysis, qualitative work, large comparative (panel) surveys, experiments, and a longitudinal measurement burst design in four countries. WP 1 will conceptualize digital hate based on a context-rich netnographic analysis of online communities. WPs 2-3 will examine the actual perpetrators of digital hate using innovative methodologies. WPs 4-5 will study the perceptions and moderation strategies by the witnessing audience and explain why audiences remain silent. WPs 6-7 will comprehensively examine the effects on and the responses by the disempowered (i.e., women and Muslims) and empowered targets (i.e., politicians, journalists, and scientists) as well as their intersections. WPs 8-9 will develop a novel multi-platform, multi-issue comparative computational analysis of digital hate that is built upon the actual perceptions of digital hate by those who receive it, rather than using predefined, potentially biased AI algorithms. A project of this scale and disciplinary breadth has never been attempted before. DIGIHATE will not only move significantly beyond the state-of-the-art in the literature, its findings will also be helpful for building and maintaining dignified societies in the digital world.

Keywords: hate speech,social media,sexism,stereotyping,incivilty
Non-canonical RNA caps - cellular reaction to environment and stress (StressRNaction)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Czechia
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 1497425.0
EU funding (EUR): 1497425.0
Participants: 1
Project status: SIGNED

The goal of this project is to understand the role of non-canonical RNA caps (mainly dinucleoside polyphosphates = NpnNs) in prokaryotes and eukaryotes. The 5' termini of the RNA are critical structures and are the least characterized among RNA modifications. In this project, we will develop selective capturing techniques for identification of NpnN-RNA sequences and identify the interacting partners of NpnN-RNA. Furthermore, we will reveal their metabolism and their role in cellular reaction to stress conditions in prokaryotes and eukaryotes. Until recently only canonical structures, NAD or CoA have been known as 5' RNA caps. We discovered an entirely new class of 5' RNA caps - dinucleoside polyphosphates (NpnN) in prokaryotic and eukaryotic cells. Based on our preliminary data we know that methylated NpnN caps stabilize RNA of E. coli in the stationary phase and that some NpnN caps can also be found in mammalian cells. We do not yet know [1] the sequence of RNAs capped with NpnNs, [2] how many types of NpnN RNA caps exist in eukaryotes, [3] whether RNA stabilization is their only role, [4] why there are so many types of NpnN RNA caps (we identified nine in E. coli), [5] whether NpnN-RNA can be translated, etc. The role of free NpnNs, identified fifty years ago, is yet to be elucidated. NpnNs are called alarmones, as their concentration increases under stress conditions. The mechanism by which the alarm is recognized in cells is unknown. I presume that their cellular effects are mediated by the RNA, where they serve as RNA caps. As such, they become an important part of RNA metabolism and can be recognized by various RNA interacting proteins, triggering additional effects in cellular metabolism. The presented project has the potential to solve the puzzle of the role of NpnNs and clarify the connection between RNA metabolism and immune response or virulence factors of viruses and bacteria.

Keywords: rna caps,dinucleoside polyphosphates,nudix enzymes,alarmones
Omnidirectional Antennas to Eliminate Wind Turbine Bird Collisions (SARCAPE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Wind farms incur significant up-front CAPEX and ongoing OPEX costs to ensure compliance with several local and EU-wide regulations on mitigating bird collisions with wind turbine blades. Existing options to address the regulation mandates are imperfect, leading to waste in wind turbine productivity, potential temporary and permanent closures of wind farms, and overall reduced economic sustainability of wind farms. Leaving the issue unaddressed risks the EU missing 2030 Green Deal goals for expansion of renewable energy consumption. To address the issue, Alika is developing SARCAPE, a breakthrough set of unique omnidirectional radar antennas and proprietary AI-based detection software, aiming to prevent 99% of bird collisions in wind farms. It will be the world’s first system capable of detecting and classifying even the smallest of birds and bats (e.g. 5g pipistrelle bat) with extreme precision. Its patent-pending radar technology requires installation of just one small master radar + repeater antennas, easily stuck to the turbines themselves through powerful magnets. This breakthrough master radar system leverages machine learning to achieve 24 bird trajectory estimate updates per second compared with 1 per second of other long-range tower radar systems, ensuring both false negatives and positives are minimised. SARCAPE would be 30-50% of the upfront price and ~50% of the annual maintenance price of competitor solutions. Eliminating productivity losses from the seasonal shut downs currently used to minimise bird collisions would save an estimated at €105,000/year per turbine. Reducing turbine blade damage caused by bird collisions could save a portion of the €30,000-€200,000 spent annually on repairs. Based on the options currently available to wind farms to comply with local and EU-wide regulations, SARCAPE’s solution is by far the most economical and effective and would be the first solution capable of wide-scale adoption.

Keywords: wind turbine,bird collision,antennas
POWERING ARTISTIC AND CULTURAL ENTREPRENEURSHIP TO DRIVE THE CLIMATE TRANSITION (PACESETTERS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Norway,Ireland,Poland,Netherlands,Italy,Germany,United Kingdom,Spain
Call: Cultural and creative industries for a sustainable climate transition (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 3771900.0
EU funding (EUR): 3771900.0
Participants: 15
Project status: SIGNED

PACESETTERS responds to the abstract challenge of the climate transitions by shifting from a model of entrepreneurship based on individual, short-term incentives to one that is driven by co-agency and new capacities to act together in sustainable ways. It does so by examining the concrete circumstances, investigating possible support mechanisms and stress-testing instruments that enable art and culture, creativity and heritage to drive the climate transition. Therefore, PACESETTERS will set out to: -Create knowledge from collaborative research to keep pace with the transition -Propose and test creative business models to set the pace of the transition -Assess strategies of valorisation to push the pace of the transition This approach will identify and analyse advanced practices that run transversally across the cultural and creative sectors; contextualise the outcomes of co-research in real-world laboratories for social imagination; further develop and promote the preliminary results of experiments in iterative support and evaluation frames. The PACESETTERS approach centres on inclusion, participation and iteration in order ensure that gender equity and diversity inform it at every step and on every level. The result will be a critical evaluation and all-encompassing demonstration of the actual potentials of the CCIs to drive the climate transition while systematically analysing their impact on micro-, meso- and macro-level: -Understanding the climate transition as a triple transition: green, digital and inclusive -Innovating aPACESETTERS responds to the abstract challenge of the climate transitions by shifting from a model of entrepreneurship based on individual, short-term incentives to one that is driven by co-agency and new capacities to act together. It does so by examining the concrete circumstances, investigating possible support mechanisms and stress-testing instruments that enable art and culture, creativity and heritage to drive the climate transition.

Keywords: art,culture,creativity,cultural heritage,sustainability,climate transition,
Rethinking Global Supply Chains: measurement, impact and policy (RETHINK-GSC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,France,Denmark,Poland,Norway,Belgium,Austria,Hungary
Call: Towards a new normal? Employment and social impacts of changing supply chains and declining trade intensities (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2999878.0
EU funding (EUR): 2999877.75
Participants: 12
Project status: SIGNED

The changing nature of global supply chains requires a rethinking of GSCs in the design of appropriate policy responses and in taking into account their employment and social impacts. The overall goal of RETHINK-GSC is to enhance our understanding of the impact of GSCs using new measures that can quantify the role knowledge flows, and more generally services inputs, and thus acknowledge the increasing importance of intangibles in global production. The project provides new and innovative methodologies for assessing the development of global supply chains, which generates new knowledge on ongoing and expected changes in GSCs due to shocks. The research, both theoretical and empirical, will be conducted mainly at the level of the firm – the unit that ultimately decides on the organisation of international production. Using the RETHINK-GSC innovative measures allows the projects’ researchers and future scholars (i) to investigate the interaction between tangible and intangible GSCs to evaluate the changing nature of global supply chains, (ii) to provide novel ways of analysing the impact of GSCs on social, economic and environmental outcomes in European countries and (iii) to evaluate the resilience of GSCs to exogenous shocks. Furthermore, the project elaborates policy scenarios for expected future GSC developments. This new evidence contributes to enhancing policy developments related to ensuring level playing fields in trade relations and ensuring security of strategic supplies. Throughout the project stages, researchers will collaborate closely with an Advisory Board consisting of a group of stakeholder experts from national governments, business associations, social partners and international organizations. Finally, and important to the project's continuing impact, the newly constructed measures of knowledge and service flows along GSCs will be made available to the wider community for research and policy analysis after completion of RETHINK-GSC.

Keywords: global supply chains knowledge flows services inputs resilience of gscs trade policy industrial policy environmental policy strategic supplies company level analysis
Effect of long-acting spatial repellents (LASR) vs indoor residual spraying (IRS) on malaria burden in western Kenya: a cluster-randomised trial (LASR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: United Kingdom,Netherlands,Belgium,Kenya,United States
Call: New tools, technologies and approaches for vector control in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 6032060.92
EU funding (EUR): 6032060.92
Participants: 6
Project status: SIGNED

Evidence of the impact of long-acting spatial repellents (LASR) on malaria burden is urgently needed. We propose to conduct a rigorous, cluster-randomised trial to evaluate the effectiveness of LASR and indoor residual spraying (IRS) in Kenya. The trial will include 66 clusters (villages) in western Kenya where malaria transmission is intense. The clusters will be randomised to one of three study arms including: (1) LASR (intervention #1) with SC Johnson’s Guardian™ product, (2) IRS with pirimiphos-methyl (intervention #2), and (3) standard control (no intervention). All clusters will receive standard malaria control interventions, including long-lasting insecticidal nets (LLINs) distributed by the Kenyan National Malaria Control Program and malaria vaccines (as and when these are deployed). The evaluation will include repeated cross-sectional community surveys (conducted at baseline and then every 6 months for 2 years) to gather information on household characteristics and parasite prevalence in children aged 2-10 years, malaria incidence as captured through health facility surveillance, entomological surveillance, mosquito behaviour studies and insecticide resistance monitoring, qualitative research to explore barriers to delivering LASR and IRS, and an economic evaluation. The primary objective of the study is to evaluate the impact of LASR (Guardian™) as compared to standard control on parasite prevalence in western Kenya. We will test the hypothesis that parasite prevalence as measured in cross-sectional surveys will be lower in intervention clusters (villages randomised to receive LASR), than in control clusters (villages randomised to standard control). The field work in Kenya will be led by the Kenya Medical Research Institute (KEMRI), coordinated by the Liverpool School of Tropical Medicine (LSTM), and supported by Radboud University Medical Centre, Netherlands, the Institute of Tropical Medicine, Belgium, and the US Centers of Disease Control.

Keywords: malaria,spatial repellents,indoor residual spraying,cluster randomised trial,kenya,africa