Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A general law describing the diffusion of membrane proteins in vivo based on single molecule tracking of membrane proteins in Escherichia coli. (D_IN_VIVO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

The ultimate goal of cell biology is to understand how proteins function in real cells and to understand their regulatory mechanisms. To achieve this goal one needs to analyze molecules in their cellular environment and not under idealized test tube conditions. A major difference between in vivo and in vitro conditions is the crowdedness (and associated molecular complexity) of the cytoplasm and biological membranes. As a consequence diffusion in this environment is significantly slower. To make biology more quantitative, we should measure the key parameters such as reaction rates and diffusion coefficients in vivo. Here, I propose an experimental set-up to measure the diffusion of membrane proteins in live bacterial cells. The main objective of this project is to establish a relationship between the diffusion coefficient and number of trans-membrane helices (radius in the membrane) of membrane proteins. The mobility of fluorescently labeled proteins will be probed at the single molecule level in the membranes of a model prokaryotic organism – Escherichia coli. Single molecule tracking of membrane proteins systematically increasing in size (radius in the membrane) will be implemented to obtain a general model of protein diffusion in the membranes. Assigning actual numbers to the parameters of a cell will provide a quantitative context for systems biology efforts and sharpen our understanding of how a cell works. By training-through-research, the fellowship will allow me to learn new techniques (single molecule tracking, programming) and how to build/align microscope set-ups. This will help me transform from a microscope user to a microscope constructor and vastly increase my potential as a cell biologist. In the international and interdisciplinary environment of the host group I will improve my ability to train and manage people, learn to translate my science, across disciplines, to a new audience and to translate fundamental research into industrial applications.

Keywords: biophysics,cell biology,single molecule tracking,quantitative biology,diffusion in vivo,super-resolution imaging of e.coli,membrane proteins
NON-GAUSSIANITY IN THE SKY (NGSKY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-03
End date: 2015-06-02
Duration (months): 24.0
Total project cost (EUR): 256364.2
EU funding (EUR): 256364.2
Participants: 1
Project status: CLOSED

A central goal of observational cosmology is to characterize the statistics of the initial perturbations of our universe, thereby constraining the physics which generated them. Observations to date are consistent with adiabatic, Gaussian, scalar initial conditions but deviation from a scale invariant initial power spectrum has been observed with 3 sigma significance. This led to a new and powerful probe of the origin and evolution of structures in the universe: primordial non-Gaussianity. The latter is an actively developed field and concerns primordial non-Gaussian contributions to the correlations of cosmological fluctuations and other cosmological observables and are widely expected to become an important probe of both the early and the late universe. In particular, on-going and future observations of fluctuations in the cosmic microwave background and the large-scale structure will test the level of primordial non- Gaussianity and therefore provide us with crucial information about the early and late evolution of our universe. We plan to pursue a number of related directions of research. In particular: (1) We will employ field theoretic methods to study non-Gaussianity sourced by particular field theory models on curved spacetime. (2) We will investigate non Gaussian perturbations generated during the inflationary de Sitter phase of the Universe by using Conformal Field Theory techniques. (3) We will perform analytical and numerical work (if needed) to evaluate the non-Gaussianity left imprinted in the cosmic microwave background anisotropies by the second-order effects where the non-Gaussianity is not only of primordial origin but receives contributions from cosmological perturbations in the post-inflationary era, and (4) We will investigate the effect of heavy massive fields of the quasi-de Sitter phase of the universe on the non-Gauusianity of the primordial perturbations due to their ultraviolet mixing with light fields.

Keywords: p301 astronomy - astrophysics and cosmology,p101 fundamental interactions and fields,p102 particle physics
Approximate Solutions of the Determinantal Assignment Problem and distance problems (A-DAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Systems and Control provide a paradigm that introduces many open problems of mathematical nature. The Determinantal Assignment Problem (DAP) belongs to the family of synthesis methods and has emerged as the abstract problem formulation to which the study of pole, zero assignment of linear systems may be reduced. This approach unifies the study of frequency assignment problems (pole, zero) of multivariable systems under constant, dynamic centralised, or decentralised control structure, has been developed. DAP is equivalent to finding solutions to an inherently non-linear problem and its determinantal character demonstrates the significance of exterior algebra and classical algebraic geometry for control problems. The overall goal of the current proposal is to develop those aspects of the DAP framework that can transform the methodology from a synthesis approach and solution of well defined problems to a design approach that can handle model uncertainty, capable to develop approximate solutions and further empower it with potential for studying stabilization problems. The research aims to provide solutions for non-generic frequency assignment problems and handle problems of model uncertainty. This is achieved by developing robust approximate solutions to the purely algebraic DAP framework and thus transforming existence results and general computational schemes to tools for control design. The research involves the computation of distances between Grassmann and families of Linear varieties, introducing a new robust methodology for Global Linearisation using homotopy theory and finally developing an integrated framework for approximate solutions of DAP and its extension to the case of stabilization problems. The research involves the study of challenging mathematical problems related to problems such as spectral analysis of tensors, homotopy methods, constrained optimization, theory of algebraic invariants and issues linked to the properties of the stability domain.

Keywords: m118 control theory and optimization
Bilayer Graphene Exciton Polariton (BIGEXPO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The topic of the project is the investigation of the physics and the applications of exciton polaritons in biased graphene bilayers. Recent theoretical calculations have shown that excitons in gapped bilayers of graphene are characterized by an extremely intense coupling to light. Coupling graphene bilayers to the photonic mode of a microcavity we thus expect to be able to reach the strong coupling regime, in which the low energy excitations of the system will be given by a new kind of polariton quasiparticle, half graphene interband electronic transition, half microcavity photon. The aim of the present project is to study the physics of such excitations, both for their fundamental physical interest and for the possibility to exploit them to realize pioneering optoelectronical devices.

Keywords: graphene bilayers,polaritons,strong coupling,ultrastrong coupling,cavity qed,exciton,optical properties,quantum simulation
Representation theory of quantum algebras and their semi-classical limits (RTQASL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The proposed research of this proposal is in algebraic Lie theory and Poisson geometry, two fields of pure mathematics with strong interactions with other sciences including computing science, chemistry, physics and economics. In recent works, the applicant developed new techniques from combinatorics/graph theory in order to study the representation theory of quantised coordinate rings, whereas the host has been developing algorithmic methods in order to study the representation theory of these noncommutative algebras. A motivating factor for the existence of this project is the desire to unite these disparate approaches to the study of quantum algebras in the hope that rapid and deep progress can then be made. That this is feasible is supported by three recent articles of the applicant and the host where combining their techniques led to the solution of a long-awaited results on the dimension of certain algebraic varieties appearing in the context of quantum algebras. More precisely, the aim of this project is to combine the techniques developed by the applicant on one hand, and by the host on the other hand, in order to fully understand the space of primitive ideals of certain class of noncommutative algebras of current interests such as quantum (affine) Schubert cells, quantum flag varieties, quantum cluster algebras. In addition, the geometric properties (normality, AS Cohen-Macaulay, AS Gorenstain...) of the prime/primitive quotients will be studied in the spirit of noncommutative algebraic geometry. All of the noncommutative algebras mentioned are actually deformations of classical varieties, and so these algebras are algebraic deformations of certain Poisson varieties. The second main aim of the project is to use these new techniques in order to understand the link between the primitive ideals of these noncommutative algebras with the symplectic leaves of their semi-classical limits.

Keywords: m102 algebra,m108 lie groups - lie algebras,m115 combinatorics
Development of novel analytical and experimental approaches for an in-depth characterization and optimization of Silicon Photomultipliers (SIPM IN-DEPTH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-09-02
End date: 2015-09-01
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Sensors capable of detecting single photons are of critical importance for a very wide range of scientific and technical applications in such areas as medical imaging, biotechnology, high energy physics, scientific instrumentation, communication, and homeland security, including, in particular, positron emission tomography, flow cytometry, Cherenkov cosmic ray telescopy, laser ranging, optical time domain reflectometry or beam loss monitoring in particle accelerators and light sources. Silicon Photomultipliers (SiPMs), in particular, are an emerging and very promising technology due to their photon number resolution at room temperature, insensitivity to magnetic fields, compactness and relatively low operating voltages. Furthermore, they are cheap to mass-produce, especially in comparison to conventional photomultiplier tubes. In order to evaluate their potential for a specific application, it is necessary to quantify their fundamental parameters as a particle detector, as well as in combination with scintillators or optical fibers used for signal generation and transport, in detail. In the frame of this Marie Curie IIF project, a comprehensive analytical probabilistic model of the SiPM response shall be developed that will take the specific excess noises of crosstalk and afterpulsing, nonlinearities and saturation effects into account. Based on this model, a full set of analysis, measurement and characterization methods will then be built up. This will allow for selecting an optimum SiPM design and model for a specific application as accelerator, nuclear or medical physics instrumentation and thus contribute to an overall improvement of the respective application. Finally, reliability and mass testing approaches and techniques, applicable for large-scale projects and focused on the balance between accuracy, simplicity and cost efficiency, shall be developed.

Keywords: photon detection medical instrumentation silicon photomultipliers optics beam loss detection
SERS ultrasensitive universal sensing of proteins through cross-reactive sensor arrays (CROSS-SERS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

The goal of the present project is the development of novel nanostructured cross-sensor reactive arrays (CRSA) based on SERS and the different affinity of peptides and proteins to interact with different metallorganic complexes. This sensor concept will be universal for the ultrasensitive detection and identification of metallic cations and peptides/proteins. Briefly, we shall fabricate micron-sized, composite nanomaterials as follows. Gold nanoparticles will be first deposited on silica or polymer microspheres via layer by layer self-assembly, and subsequent epitaxial growth will be carried out with silver (using novel methods recently developed in our lab) to generate discrete, highly SERS active surfaces. These composite particles will be functionalized with organic ligands with high affinity for metals (thiolated porphyrins and terpyridines). In a first step, quantitative multiplex ultrasensitive detection of metals will be aimed. In a second step, each microsphere coupled with one ligand and a given metal will be fabricated as a sensing element for the CRSA. These sensing elements will be organized into solid supports (the actual CRSA) and tested for the identification of different protein species, especially those related with pathogenic states or drug abuse, by combining SERS spectroscopy with chemometric methods (i.e. principal component analysis, hierarchical cluster analysis and partial least squares). The final product is intended to be mounted on a conventional glass slide with ability for drawing a rapid and accurate conclusion on the health condition of a patient, or environmental risk in a time scale of seconds.

Keywords: c102 nanochemistry,c105 surface science,c106 analytical chemistry,c107 chemical physics,c128 nanomaterials
Microeconomic and macroeconomic implications of firms' internationalization and innovation strategies: the role of demand and informational barriers. (INTINN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 223002.2
EU funding (EUR): 223002.2
Participants: 1
Project status: CLOSED

The aim of this project is to investigate on one side, whether and how trade may induce innovation by existing firms, with particular attention to product innovation and competition strategies; on the other side, it aims at giving some insights on the relationship between firms’ heterogeneity and the aggregate effects of trade liberalization in the developed economies, taking into account the composition effects both within and between industries. It is now widely recognised the role played by trade liberalization in inducing self-selection of more efficient firms. However, a new, complementary, perspective will be offered according to which foreign markets represent a source of innovation and at the same time, they entail higher costs to collect information on foreign needs and their characteristics. This research will develop along two main lines. The first research line will investigate both empirically, by carrying out qualitative and quantitative analysis on European firm-level data, and theoretically, by providing different models in a theoretical framework of location in the ‘product space’, some potential sources of innovation through international interactions. Cross-country heterogeneity in i) buyer-seller relationships ii) the competitors’ distribution in the foreign market’s “product space”, and iii) consumer tastes, will be investigated. The second line of research consists in an attempt to single out what is the relevant industry level of aggregation in analysing the macroeconomic effects of trade liberalization with heterogeneous firms. A theoretical framework suitable to analyse the aggregate trade and growth effects of cross-country specialization across industries aggregated according to new criteria will be provided, and its implication will be empirically assessed. This framework will stress the macroeconomic implications of different dimensions of firms’ and industries heterogeneity.

Keywords: economics,international trade,transnational innovation,heterogeneous firms,structural change,multisector growth models
Bioanalytical evaluation, identification, and characterisation of disinfection by-products formed during drinking water treatment (AQUABIOTOX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-08-01
End date: 2016-07-31
Duration (months): 36.0
Total project cost (EUR): 261401.7
EU funding (EUR): 261401.7
Participants: 1
Project status: CLOSED

Drinking water disinfection, mandatory to provide drinking water free of pathogens, is associated with the formation of disinfection by-products (DBPs) that have been linked to public health concerns. Drinking water chlorination produces a wide range of toxic DBPs, only a fraction of which have been identified let alone characterised for their toxic potential. Bioanalytical tools should complement chemical analysis for a comprehensive risk assessment to assure that unidentified DBPs are also captured. In vitro bioassays will enable the detection of mixture effects caused by known and unknown transformation products. However, many DBPs are volatile and polar and thus cannot be evaluated with current methods. After implementation and validation of improved extraction and dosing techniques, my goal in the proposed project is to develop a screening tool that combines cell based bioassays indicative of relevant human health endpoints with chemical analysis to identify toxicologically relevant DBPs. The combination of bioanalytical assessment with sophisticated state-of-the-art chemical analysis will provide a guidance scheme for an effect directed identification of toxicologically relevant transformation products formed during advanced water treatment processes. This aims not exclusively at single compounds but also at substance groups or toxicophores. The establishment of applicable bio-analytical screening tools will enable the toxicological monitoring of advanced treated waters and allow the evaluation of pre- and post-treatments for by-product mitigation.

Keywords: drinking water treatment,disinfection by-products,transformation products,effect-directed analysis,human health risk assessment,environmental risk assessment,water resources engineering
Interaction of Nonlinearity and Disorder: Gateways to Optics (INDIGO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 227231.2
EU funding (EUR): 227231.2
Participants: 1
Project status: CLOSED

The project seeks to train an experienced researcher (Dr Stanislav Derevyanko) to the highest level of professional competence by bringing him into a world class research group in the field of nonlinear optics at Weizmann Institute of Science (Israel). This goal will be acheived by an ambitious research programme aimed at elucidating the nature of the complex interplay between nonlinearity and disorder using arguably the most illustrative example where it occurs: disordered beam propagation in nonlinear photonic waveguides and lattices. The main specific objectives of the project will be 1) to apply the methods of statistical physics to describe the thermalization of light in 1 and 2 dimensional waveguide arrays at arbitrary level of nonlinearity. 2) to study the propagation of an optical beam in disordered optical lattices and study the impact of disorder on the refractive properties such lattices 3) to build a theory of the nonlinear Hanbury-Brown and Twiss interferometer where the information about the angular size of a light source is extracted by analysing an intensity correlation of the speckled light field. In additon to purely research objectives additional complementary training in such skills as reserach commercialisation and project management will be provided to aid Dr Derevyanko's further career development. Although the project is theoretical in nature the fellowship will be taken place in a leading world-class experimental group in the field which creates a unique opportunity of immediate verification and testing the outcomes of the project and increasing its scientific impact.

Keywords: p108 optics and quantum optics,p114 non-linear physics