Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Widefield Raman imaging probe for intraoperative margin assessment of cancers (IMAGINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Positive cancerous margins after surgery lead to an increased risk of progression and reduced disease free survival. Obtaining clear margins of cancerous lesions can be very challenging during surgery. Raman spectroscopy is a unique label-free optical technique based on inelastic light scattering that offers tissue "optical biopsy" at the molecular level. IMAGINE is a multidisciplinary approach that aims to develop the first widefield near-infrared (NIR) Raman imaging probe for intraoperative margin assessment. A new ultra-high sensitive InGaAs focal plane array (FPA) camera integrated with a novel combination of band-pass filters will be integrated to selectively probe the biomolecular constituents of tissues in the high-wavenumber range (i.e., 2800-3600 cm-1) providing a new endogenous biomolecular contrast mechanism for visualisation of resection margins during cancer surgery. A prototype will be developed and applied ex vivo on excised tissues from colorectal cancer patients. Histopathology will serve as gold standard and the sensitivity, specificy, receiver operating characteristics (ROCs), tumour contrast, and potential clinical/surgical impact will be evaluated. The new optical bioimaging modality proposed here constitutes a simple non-invasive cost-effective and broadly applicable technique for margin assessment of cancers compatible with in vivo laparoscopic settings. This translationally driven project fosters multidisciplinary research involving bioengineering, optical engineering and clinical research and has the support of a strong international industrial secondment. IMAGINE will enhance the mobility and innovative potential of the applicant and open new avenues in cancer surgery, which will strengthen the scientific excellence in Europe and ultimately benefit the patients.

Keywords: raman spectroscopy,widefield raman imaging,noninvasive,label free diagnosis,cancer
Reusable, returnable packaging for e-commerce (RePack)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Finland
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

RePack is a sustainable packaging system for online retailers and shoppers whereby delivery packages can be conveniently and easily returned, and then re-used. It is a system level innovation and its business model consists of three elements: 1) Reusable design packaging; 2) Stock, deposit management, and track and trace software; and 3) Market place for voucher use. In Europe alone 3,7 billion disposable packages are sent to consumers annually. Ecommerce market has evaluated market size as 312 billion Euros and growing at almost 20 % annually (Ecommerce Europe, 2013). For webstores disposable packaging is a wasted opportunity to improve consumer experience, increase consumer loyalty and improve their supply chain efficiency. This behavior is wasteful from the perspective of consumers, webstores, environment and society as a whole. RePack end users save money on their next purchase and web stores improve consumer loyalty while offering environmentally sustainable delivery alternative to disposable packaging. The main specific objective of the feasibility study is to pilot RePack in other EU markets. This pilot is used to gather consumer and webstore feedback to identify benefits and analyse bottlenecks in the ecommerce value chain in EU markets. Our current analysis is that the main bottleneck is lack of awareness regarding our innovation outside Finland, limited sales channels, lack of e-commerce contacts and long sales and project cycles. This is especially related to fashion ecommerce. We want to further investigate these bottlenecks, increase awareness of our solution and accelerate Repack adoption cycles.

Keywords: ecommerce,logistics,packaging,reuse,circular economy
Rapid monitoring of biomarkers in postoperative care (MD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Colorectal cancer is the third most common cancer in the world, with nearly 1.4 million new cases diagnosed in 2012. The frequency of complications after surgery is relatively high, but rapid and safe monitoring methods are missing. MD Biomedical AB has addressed this need and developed a radically new and innovative piece of medical equipment that is gently attached on the surface of the bowel for sampling of biomakers. This makes it possible to detect complications within minutes, at an early stage of illness, and long before patient systemic indications. The possibility of rapid counteractions improves the treatment of the patient and save health care costs. The feasibility study comprises one work package divided in 6 tasks and shall in measurable terms assess the functional, medical, economic, and environmental effects and the deliverable is a feasibility report including a business plan.

Keywords: postoperative,monitoring,medical care,intensive care,biomarker,glucose,lactate
Gen Duplication and Amplification in Staphylococcal populations (GDA in staphylococci)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-03-02
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Bacterial pathogens possess the ability to adapt rapidly to changing environmental conditions which is especially apparent in the hospital setting where bacteria acquire antibiotic resistances readily. Besides well studied mechanisms such as horizontal gene transfer bacteria can alter the genetic material by acquiring gen duplications and amplifications (GDA). Exemplarily an improved gene dosage of a minor resistance determinant can lead to increased resistance to antibiotics. Due to the difficulties in their detection GDAs are almost exclusively studied in model organisms and neglected in natural populations of clinically relevant species such as Staphylococcus aureus. Accordingly many important questions about the frequency and clinical importance of GDAs remain unanswered. State of the art sequencing technologies enable the identification of GDAs by analysis of the coverage scaffold and groundbreaking experiments using 387 USA300 genome sequences showed promising results regarding putative copy number variation of virulence factors. We will extend the GDA analysis to ca. 1200 already available EMRSA15 sequences. This will enable a comprising analysis of gen copy number variation in clinical isolates and might allow identifying genomic regions under strong evolutionary pressure during infection. We will optimize experimental setups for the rapid validation of GDAs by qPCR and develop techniques to study the effects of GDAs in S. aureus. Furthermore we will sequence a selection ca. 70 S. aureus isolates causing chronic infections in patients suffering from cystic fibrosis (CF). This will enable us to optimize the detection of GDAs by NGS and will allow investigating the role of GDAs during adaption to the complex environment within the CF-lung. This project will show new avenues to extract additional valuable biological information from NGS data and will investigate the importance of GDAs during the adaption of S. aureus to the hospital setting and to the CF-lung.
Breathing Oceans: understanding the organic skin that modulates the exchange of greenhouse gases between the atmosphere and the ocean (BOOGIE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1960748.0
EU funding (EUR): 1960748.0
Participants: 1
Project status: SIGNED

Oceans are a global reservoir of greenhouse gases, estimated to account for 20–40% of the post-industrial sink for anthropogenic carbon dioxide (CO2). However, quantifying the exchange of gases such as CO2, methane (CH4), and nitrous oxide (N2O) between the ocean and atmosphere is a major challenge. Understanding how the ocean’s organic skin layer modulates this exchange is critical to estimate the intrinsic oceanic sinks and sources of these key greenhouse gases both now and in the future. Organic substances in the skin layer, known as surfactants, span across traditional operational definitions and are derived from multiple sources undergoing biotic and abiotic transformations along the land-ocean continuum. This proposal will investigate a land-ocean transect from South America toward the African Continent to investigate organic matter control of air-water gas exchange. Central to this work is the application of new technologies, using novel in-situ sensor platforms and advanced geochemical characterisation techniques. This new and unique data will be incorporated into hydrological and gas flux models to examine spatial and temporal effects of surfactant suppression of gas exchange – both now and in the future.

Keywords: gas exchange,organic matter,dissolved,particulate,surfactant,land ocean continuum
Pioneering a New Path in Parallel Programming Beyond Moore’s Law (BeyondMoore)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Türkiye
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

BEYONDMOORE addresses the timely research challenge of solving the software side of the Post Moore crisis. The techno-economical model in computing, known as the Moore’s Law, has led to an exceptionally productive era for humanity and numerous scientific discoveries over the past 50+ years. However, due to the fundamental limits in chip manufacturing we are about to mark the end of Moore’s Law and enter a new era of computing where continued performance improvement will likely emerge from extreme heterogeneity. The new systems are expected to bring a diverse set of hardware accelerators and memory technologies. Current solutions to program such systems are host-centric, where the host processor orchestrates the entire execution. This poses major scalability issues and severely limits the types of parallelism that can be exploited. Unless there is a fundamental change in our approach to heterogeneous parallel programming, we risk substantially underutilizing upcoming systems. BEYONDMOORE offers a way out of this programming crisis and proposes an autonomous execution model that is more scalable, flexible, and accelerator-centric by design. In this model, accelerators have autonomy; they compute, collaborate, and communicate with each other without the involvement of the host. The execution model is powered with a rich set of programming abstractions that enable a program to be modeled as a task graph. To efficiently execute this task graph, BEYONDMOORE will develop a software framework that performs static and dynamic optimizations, issues accelerator-initiated data transfers, and reasons about parallel execution strategies that exploit both processor and memory heterogeneity. To aid the optimizations, a comprehensive cost model that characterizes both target applications and emerging architectures will be devised. Complete success of BEYONDMOORE will enable continued progress in computing which in turn will power science and technology in the life after Moore’s Law.
International Fellowship Programme for Talent Attraction to the Campus of International Excellence Campus Iberus (IberusExperience)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 2427480.0
EU funding (EUR): 1213740.0
Participants: 1
Project status: SIGNED

The proposed MSCA COFUND FP “IberusExperience - International Fellowship Programme for Talent Attraction to the Campus of International Excellence Campus Iberus” is promoted by Campus Iberus, a strategic partnership which brings together four high-profile research universities from four different regions along the Ebro valley in northeastern Spain: Universidad de Zaragoza, Universidad Pública de Navarra, Universitat de Lleida and Universidad de la Rioja. IberusExperience tables a competitive and attractive research environment of inter-connected regions and universities, bringing together 4 recruiting universities and a total of 88 academic and non-academic partner organisations from 26 countries committed to host secondments and/or to offer trainings, networking events and others actions to enhance the career opportunities of the researchers. IberusExperience will offer 11 positions for worldwide excellent Experienced Researchers (ER) who are willing to develop individual and free-choice innovative research projects for a period of 36 months in any of the five areas of specialisation of Campus Iberus: 1) Agro-food & Nutrition; 2) Health Technologies; 3) Energy, Environment & Sustainability; 4) Social & Territorial Development; 5) Circular Bio-Economy. The IberusExperience Programme is planned to start on July 2021 and last for 60 months. It involves one call for applicants and the evaluation of the research proposals by international independent experts. The recruitment of the 11 talented researchers is expected to be achieved before M18. The programme is not just aimed at talent attraction but consolidation and retention. Researchers will have the opportunity to be extensively trained in research and transferable skills and consolidate their professional careers at the regions. Anchoring these highly skilled professionals will definitely boost the international dimension and competitiveness of Campus Iberus and surrounding R&I ecosystem.

Keywords: health,technology,food,agro,energy,sustainability,bioeconomy,social,territorial,interregional,clusters,ebro valley,campus of international excellence
WORLD CLASS INNOVATIVE NOVEL NANOSCALE OPTIMIZED ELECTRODES AND ELECTROLYTES FOR ELECTROCHEMICAL REACTIONS (WINNER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Spain,Norway,Sweden,Norway,France,Netherlands,Denmark
Call: HT proton conducting ceramic materials for highly efficient and flexible operation (H2020-JTI-FCH-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2931788.75
EU funding (EUR): 2931788.75
Participants: 8
Project status: SIGNED

The WINNER project will develop an efficient and durable technology platform based on electrochemical proton conducting ceramic (PCC) cells designed for unlocking a path towards commercially viable production, extraction, purification and compression of hydrogen at small to medium scale. This will be demonstrated in WINNER in three applications: ammonia cracking, dehydrogenation of hydrocarbons, and reversible steam electrolysis. By such, WINNER will create innovative solutions for flexible, secure and profitable storage and utilization of energy in the form of hydrogen and green ammonia, electrification of the chemical industry and sectors coupling. The WINNER project builds on the pioneering multidisciplinary expertise of world leading partners in the fields of proton conducting ceramic (PCC) materials and technologies to combine materials science, multi-scale multi-physics modelling and advanced in-situ and operando characterisation methods to unveil unprecedent performance of tubular PCC cells assembled in a flexible multi-tube module operating at industrially relevant conditions. WINNER will develop innovative cell architectures with multifunctional electrodes and a novel pressure-less current collection system using eco-friendly and scalable manufacturing routes. These activities will be steered by a novel multi-scale multi-physics modelling platform and enhanced experimentation methodologies. These tools combined with advanced operando and in situ methods will serve at establishing correlations between performance and degradation mechanisms associated with both materials properties and interface's evolution upon operation. Testing of cells and modules will also be conducted to define performance and durability in various operation modes. Techno-economic assessment of the novel PCC processes will be conducted as well as Life Cycle Assessment. The project is coordinated by SINTEF with support from UiO, CSIC, DTU, SMT, CTMS, ENGIE, Shell.

Keywords: proton ceramic conducting reactors,multi scale multi physic modelling,electrochemistry,novel cell s architectures
Investigating the regulation of iron homeostasis by erythroferrone and therapeutic applications (INVESTIGERFE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-05-01
End date: 2023-02-28
Duration (months): 70.0
Total project cost (EUR): 1499235.0
EU funding (EUR): 1499235.0
Participants: 1
Project status: CLOSED

The existence of an “erythron-related regulator” that intensifies iron absorption and its release from stores to meet the requirements for red blood cells synthesis was proposed in the 1950s. Delineating this mechanism is of high biomedical importance as the pathway could be targeted to develop novel treatments for iron-restricted anemias that are very frequent but for which current therapies are ineffective (e.g. infections, inflammatory bowel disease, cancer, or chronic kidney disease) and for iron-loading anemias (e.g. thalassemias). We have recently identified the hormone erythroferrone (ERFE) and showed that it could be the long-sought erythroid regulator of iron homeostasis. ERFE suppresses the synthesis of the iron-regulatory hormone hepcidin to facilitate the recovery from anemia but leads to secondary iron overload in β-thalassemia. The potential of ERFE in the treatment of iron disorders is tremendous but understanding its mechanism of action is a prerequisite to envision ERFE-based therapies. The identification of ERFE has opened new research areas and our project will be organized around four axes. 1) Develop an assay to measure ERFE levels in human pathologies. Its contribution is not known and needs to be confirmed. 2) Identify the receptor for ERFE, the signaling pathways triggered by ERFE, and molecules with agonist/antagonist effects, a prerequisite in the development of new therapies. 3) Search for potential other erythroid regulators. We will take advantage of the Erfe-/- mice to determine whether hepcidin could be suppressed by an ERFE-independent mechanism. 4) Study the potential of ERFE manipulation in therapy in the mouse. We will first establish a proof of principle in a mouse model of anemia (B. abortus). The benefits of ERFE antagonization will be addressed in thalassemic mice. We will also examine the role of ERFE in murine models of chronic anemia: chronic kidney disease, inflammatory bowel disease, rheumatoid arthritis and infections.

Keywords: iron,anemia,erythropoiesis
High precision and performance heliostat for variable geometry fields of Thermosolar Plants (HELITE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TEWER has verified that solar fields implemented today are calculated considering a unique design of heliostat and presenting heliostat is not only characterized by the energy which is able to reflect but by how it is reflected. The configuration of the solar field and the influence of geometrical factors are directly related to the production and it is essential to take into account regarding the design, all weather operation conditions in order to get a high technology performance. Until today, although the market is asking for it, there is no product that allows variable geometry designs of solar field, allowing them to increased the energy efficiency and the overall performance from the field, improving the relation benefit/cost of current systems. TEWER aims to use this need to sell their pioneer solution in the field of engineering for solar power energy by concentration to be able to demonstrate management companies of solar plants that their product offers a much more efficient and cost-effective technology than the one that exists currently.

Keywords: heliostate,solar field,thermal solar plant,energy,renewable,high performance,facet