Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The historical evidence for European environmental and meteorological extremes AD 400 – 1000. (HEEEME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Understanding our environmental history is one of the most urgent research tasks facing humanity. Despite the necessity of improving our understanding of global environmental trends, our knowledge of environmental conditions in the period AD 400 – 1000 is very limited compared to that for the years post AD 1200. Yet very recent advances in regard to obtaining scientific natural proxy data and the ability to locate and analyse a significant corpus of historical European documents offer the prospect of an invaluable insight into the climate of the early medieval era. At the heart of the current proposal is the conviction that a medieval historian with expertise in working with Europe’s annals and chronicles, working among colleagues with a strong engagement with medieval social history, can compile accurate environmental data from the documentary sources for the period AD 400 - 1000. Prior to the eleventh-century the volume of available contemporary sources in Europe is known to decrease significantly and this has deterred historical climatologists from tackling such an early period. But this does not mean that relevant information is not available. Using modern historical source criticism to indicate the prospective reliability of the information obtained from the documents, the results obtained by the two years of research will be put into a database in a form that will allow statistically valid comparison with scientific environmental natural ‘proxy’ data.The goal of this research proposal, however, is not just to compile an innovative database of early medieval environmental information, but to use the comparison with the scientific proxy data to provide answers to very fundamental and ‘high level’ questions such as whether there was a Medieval Warm Period? Or: what were the societal consequences of abrupt climatic changes and extreme weather events? And perhaps most important of all: how anomalous is the recent large-scale phase of climate warming.

Keywords: v201 climatology and climate change,s404 medieval history
Coherent Broadband Networks Embedding Smart Photonics for Cost-Effective Quintuple-Play (WARP-5)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-05-01
End date: 2016-04-30
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

WARP-5 is driven by the internet explosion and the question for sustainable bandwidth delivery. It endeavours the advancement of optical metro-access networks through the new paradigm of coherent ultra-dense WDM systems. Under the umbrella of Fibre-to-the-Home as ICT field with high market potential, efforts towards capacity and reach extension pose severe system complexity and require a disruptive yet straightforward solution. WARP-5 aims to provide the required potential for a next-generation photonic Tb/s-capacity ICT infrastructure and the required credentials for low cost and power consumption. It does so by tackling two important pillars of ICT networks: their capacity and scalability. WARP-5 will unlock the potential of advanced modulation formats in cost-sensitive ICT segments such as optical access. A novel modulation scheme for off-the-shelf devices radically improves simple intensity modulation towards 16-level QAM. The applied technique lifts the guaranteed per-user data rate to 10 Gb/s, without raising cost and energy consumption. The 30-fold increase in the granted bandwidth with respect to the commercially available standards such as XG-PON comes with a high spectral occupancy and 5 GHz channel spacing. Scalability of common ICT infrastructure will be guaranteed not only by the envisaged transition from the electrical TDM domain to the pure optical and highly granular WDM domain; WARP-5 adopts a disruptive amplification scheme that transforms background noise into supportive gain without electrically powered field equipment, providing a "green" and effective solution to smoothly grow and migrate the network through reach/split extension. WARP-5 will demonstrate a next-generation ICT infrastructure with a long reach of 100 km and beyond, an aggregated capacity of up to 5 Tb/s and a high density of 1000 users. WARP-5 will strengthen the European leadership in coherent access networks by raising the research independence and performance of Dr. Schrenk.

Keywords: telecommunications engineering,photonics,optical telecommunications,optical broadband networks,fibre-to-the-home
Dynamics, Spectral Theory, and Arithmetic in Quantum Chaos (DSTAQC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposal aims to study the relationship between the spectrum of the Laplacian on a compact hyperbolic surface, and the geometry and dynamics of the geodesic flow on the surface, in the context of the Quantum Unique Ergodicity (QUE) Conjecture--- which asks for the eigenfunctions to become equidistributed in the large eigenvalue limit. It is thought that this question might be related to the problem of bounding multiplicities in the spectrum, and that large degeneracies could hypothetically cause QUE to fail. We investigate this aspect by studying quasimodes, or approximate eigenfunctions, where we have more control over the ``multiplicities" by adjusting the order of approximation to true eigenfunctions. There are two main objectives in this proposal. First, to solidify the connection between multiplicities and non-equidistribution; in particular, by showing that when the order of the quasimodes is weakened to the appropriate level, the QUE property fails. Second, in contrast, to show that there is variation across different dynamical ``models" of quantum chaos, in the relationship between large spectral multiplicities and types of localization phenomena. It is hoped that this program will shed light on the role of spectral multiplicities in the QUE problem in particular, and on the mysterious relationship between spectral data of the Laplacian and the geometry and dynamics of the underlying system in general. Since the questions to be studied and the methods to be used cut across many different active research areas, it is likely that this program will lead to diverse collaborations, and contribute to a wide variety of research topics in the future.

Keywords: m111 ode and dynamical systems,m106 geometry,m103 number theory,m113 mathematical physics
Chemical biology of autophagy (CHEMBIO_ATG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Autophagy is a cellular pathway that regulates the degradation and recycling of proteins and organelles. This mechanism is initiated with the formation of a phagophore, a cup-shaped double membrane that engulfs the cytoplasmic material to be degraded. The phagophore is then elongated and sealed to generate an autophagosome that will be fused with a lysosome, thereby delivering the cargo for degradation. Several ubiquitin-like proteins have been shown to have a crucial role in regulating autophagosome generation and its fusion with the lysosome. One of these proteins is LC3-I, is a soluble cytosolic protein that associates with the autophagosome after C-terminal conjugation to a phosphatidylethanolamine unit (LC3-II). This membrane association is reversibly modulated by the cysteine protease atg4, which deconjugates PE from LC3-II, thus recycling the soluble LC3-I. Detailed studies of the molecular mechanism regulating autophagosome formation and the role of LC3-I and LC3-II are unknown, mainly due to the lack of tools enabling a profound characterization of these processes. Herein, we propose the generation of semisynthetic lipidated LC3 proteins using a chemical biology approach. The fully modified proteins should be unvaluable tools that will contribute to the characterization of the factors regulating autophagy.

Keywords: c134 biological chemistry,c143 protein chemistry,l105 protein synthesis - modification and turnover,l102 general biochemistry and metabolism
Investigating the Effect of Interface Structure on Friction at the Nanoscale (INTERSTRUCFRICNANO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The physical phenomenon of friction is the main source of energy “loss” in a number of technical applications and industrial processes. Despite this fact, which holds significant economic importance, a complete understanding of fundamental physical principles governing frictional processes is still lacking. Considering that an ability to predict and control macroscopic friction depends on accurate investigations of friction at the nanometer scale, the research area of nanotribology –the science of friction, lubrication and wear at the nanoscale– has been established about 25 years ago. The main scientific tool that spearheaded developments in this field, the friction force microscope (FFM), provided researchers with a great deal of insight regarding frictional properties of nanoscale “single-asperity contacts” on different substrates as a function of various experimental parameters. Despite this success, many open questions remain regarding friction at the nanoscale, due to inherent limitations of the single-asperity FFM technique in terms of contact area, choice of materials, and poorly-characterized interface structures. Being motivated by recent developments in the field, we propose in this grant application to investigate the frictional properties of structurally well-defined, crystalline gold “nanoislands” on a number of substrates such as graphite and graphene using commercially available atomic force microscopes, as a function of island size, shape and crystallographic direction of motion. Additionally, we propose to use nanoislands made from bulk metallic glass (BMG) in amorphous and crystalline form, to test the influence of interface crystallinity on friction at the nanoscale. It is expected that the 4-year research plan described in this proposal will contribute significantly to the understanding of structure-friction relationships at the nanoscale, bringing the scientific community closer to a complete physical picture of the fundamentals of friction.

Keywords: friction,nanotribology,atomic force microscopy,surface science,nanoscale materials science and engineering
Non Boiling two phase Microfluidics with Heat Transfer (NBM-HT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The project with support of the CIG has provided great encouragement for me to establish myself in the UK for a life-long career in microfluidics and heat transfer based research activities. This grant will support me in my first steps of a stable European research career and to attain lasting professional integration in the ERA by evolving into a permanent position at the University of Oxford within a five year period. The CIG will provide me with a substantial research budget that will allow me to accelerate my research activities over the next four years and ensure continued participation at an international level through conferences and continued professional development thereby greatly enhancing my prospects for reaching the required level of long term integration through a permanent research/academic position at the University of Oxford which will have the highest possible impact to the success of my research career. In addition, I am a very experienced researcher and hence there will be significant scope to allow the transfer of knowledge that I have acquired prior to the Career Integration Grant. In addition the Osney group at the University of Oxford, which I will become a member of for the period of this grant and beyond, has a long list of industrial partners which will ensure the development of lasting co-operation with the scientific and/or industrial environment of the country from which they have moved. Without such actions as this CIG the potential for my future research activities could lie outside of the REA, while success in this proposal will solidify and act as a strong foundation to build a life-long research base at Oxford, and not only continue collaboration with my current employer but also with my many industrial contact and academic collaborations as evident from my CV.

Keywords: g313 micro(system) engineering,g305 fluid mechanics - hydraulic- - turbo- - and piston engines,g312 mechanical and manufacturing engineering
Entangled Histories: The Historical Archaeology of Anglo-Indigenous Interactions in Colonial New England (ENTANGLED HISTORIES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This project explores Anglo-Indigenous interactions in colonial New England via historical archaeology. It draws upon archival data collected on both sides of the Atlantic Ocean along with archaeological data collected from three sites in North America. Together these data offer the opportunity to investigate the complexities of cultural continuity and change in colonial contexts, to examine the long-term outcomes of such interactions for both colonizer and colonized, and to bring these patterns into dialogue with broader debates concerning social identity, cultural change, and post-colonialism. In terms of career development, grant funds will be used to complete two major parts of this research: 1) the publication stage of the first phase and 2) the data collection stage of the second. The first phase concerns two archaeological sites: Brothertown, New York and Brothertown, Wisconsin. Each was home to the Brothertown Indians, a multi-tribal Christian Indian community who emerged out of the colonial tensions of eighteenth-century New England. Archival and archaeological data associated with each locale has already been collected, analyzed, and interpreted. Grant funds will be used for the publication stage of this portion of the research project and applied towards finishing a book on Brothertown archaeology and history slated for publication with the University of Arizona Press in late 2013. The second phase concerns the Cochegan Site in Montville, Connecticut, an interethnic site occupied by both Mohegan Indians and English settlers during the eighteenth and nineteenth centuries. The Cochegan Site marks a landscape of continual Mohegan-English interaction as it contains a sacred stone landscape—used by members of the Mohegan Tribe since the seventeenth century—and an English farmstead—owned and operated by the Baker family during the eighteenth and nineteenth centuries. Funds will be used to continue a subsurface survey and excavation program begun in 2011.

Keywords: historical archaeology,colonialism,collaborative archaeology,postcolonial theory,native north america,modern world,archaeological theory,material culture,environmental archaeology
Unravelling the immune signature of natural malaria transmission blocking immunity by protein microarray (SIGNAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Malaria continues to be the most important parasitic disease with as many as one million deaths annually. Despite these sobering figures, there is a decline in the burden of malaria that has stimulated researchers to set an agenda for worldwide malaria eradication. Malaria transmission blocking vaccines (MTBV) that induce antibody responses that prevent the transmission of malaria from man to mosquito are high on the priority of this research agenda. However, the number of MTBV candidates has remained practically unaltered in the last 20 years and none have successfully entered clinical trials. This proposal aims to provide a leap forward in the identification of novel MTBV target antigens and unravelling the immune signature of naturally acquired transmission blocking immunity (TBI). For this purpose, samples will be used that have been collected in large-scale epidemiological studies, where they were included in mosquito feeding assays in the field to confirm their transmission potential. TBI will be confirmed by adding purified IgG to cultured gametocytes in the highly standardized standard membrane feeding assay (SMFA) at the Nijmegen Centre for Molecular Life Sciences of the Radboud University, Nijmegen. Functional TBI will be quantified as the reduction in the proportion of infected mosquitoes compared to malaria naïve control IgG. Samples with and without evidence for TBI will be matched for cumulative malaria exposure and used for immune profiling using a recently developed protein microarray. This protein microarray contains >20% of the P. falciparum 5,400-protein proteome and more than 300 uncharacterized sexual stage specific proteins that may be involved in TBI. By combining novel immunological, entomological and molecular tools, our approach will plausibly identify novel targets for TBI and lead to new horizons for MTBV development.

Keywords: l610 parasitology,l611 prevention and treatment of infection by pathogens,l709 public health and epidemiology,l602 adaptive immunity,l203 proteomics
Are saliva proteins key determinants of host plant specificity in the pea aphid complex? (APHISPIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Aphids are insect pests that feed on plant phloem sap and cause feeding damages and transmission of plant pathogens. The pea aphid (Acyrthosiphon pisum) complex is consisted of multiple biotypes each of which specialized to specific legume plants. Aphids use a specialized mouth part to puncture plant phloem sieve cells and suck plant nutrients. During the feeding process, aphids secrete saliva which contains various proteins that might interact with plant proteins. Interestingly, the pea aphids carries various facultative symbionts and one of which, Regiella, is known to increase aphid adaptation to clover plants. This project aims to examine the role of aphid saliva proteins and aphid symbionts in host plant adaptation. Based on previous works in plant microbe interactions, I hypothesize that aphid saliva proteins function like microbial pathogen effectors. Thus, I anticipate that the saliva proteins that are involved in host adaptation process are under high evolutionary pressure and show differential expressions or polymorphisms between biotypes. I will examine transcription profiles and sequences of salivary gland genes of the aphids that belong to different biotypes. Aphid gene silencing and in planta transient protein expression will be employed to examine the roles of the saliva genes in plant-aphid interactions. I will also examine the Regiella strains that does/does not increase aphid adaptation to clover plant to understand the host adaptation mechanisms of the aphids. I will conduct transcription analysis and saliva proteomics of the pea aphids with and without the Regiella strains. The project will improve our knowledge on the roles of aphid saliva proteins and symbionts in plant-aphid specialization process and will be the first step to contribute to develop benign strategies to control aphids in the field.

Keywords: l101 molecular biology and interactions,l810 symbiosis,l202 transcriptomics,aphid,effector,saliva protein,plant-insect interaction,facultative symbiont