Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular mechanisms underlying Zika virus transmission by Aedes aegypti mosquitoes (ZIKVMosTransmit)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-16
End date: 2025-01-15
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

The public health response to emerging mosquito-borne viral diseases is often inefficient, because the causative agents are recognized and the prevention measures are deployed, only after the disease has spread. To predict which viruses and mosquitoes have the highest potential to cause future outbreaks, understanding the mechanisms determining the virus susceptibility of mosquitoes and the mosquito transmissibility of viruses is needed. In this study, I propose a two-pronged approach to identify both the viral and mosquito factors involved in molecular compatibility between the human pathogenic Zika virus and its main vector Aedes aegypti by combining my skills in molecular virology with the host lab’s expertise in mosquito experimental infections in vivo. First, I will examine the mosquito-virus protein interactome by a proteomics strategy based on cross-linking, immunoaffinity purification and mass spectrometry. Mosquito factors regulating virus susceptibility will be identified by subtractive comparison of virus-binding mosquito proteins between two mosquito strains displaying different levels of Zika virus susceptibility. The correlation between virus susceptibility and the identified proteins will be validated by gene-knockdown assays and expression surveys using a collection of mosquito strains. Second, I will use an innovative reverse genetics system to create chimeric Zika viruses from two parental virus strains with different levels of mosquito transmissibility. The viral genes required for efficient transmission by mosquitoes will be identified by comparing transmissibility between chimeric constructs. Together, this project will provide important new insights into vector-virus specificity and significantly improve our understanding of mosquito-borne virus emergence.

Keywords: arthropod borne virus,zika virus,aedes aegypti,virus susceptibility,mosquito transmissibility,virus mosquito interaction,system biology
THermochemical storage Utilization eNabling Data centre seasonal Energy Recovery (THUNDER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Italy,Sweden,Spain,Bulgaria,Belgium,Greece,United Kingdom
Call: Waste heat reutilisation from data centres (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7197631.25
EU funding (EUR): 5586330.5
Participants: 14
Project status: SIGNED

Worldwide Data centers (DC) are estimated to account for 1 to 2% of electricity usage. Regarding the European context, it is expected that data centres will account for 98.5 TWh/year in 2030. So it is evident that there is an important potential to recover waste heat from the cooling processes of DCs. The THUNDER project aims to overcome existing barriers hampering a wide adoption of DCs waste heat recovery strategies, providing an innovative, efficient and cost attractive Seasonal Thermal storage based on Thermochemical Materials. THUNDER solutions stretch across the value chain (data centre innovative storage providers, heat pump manufacturers and district energy company operators). The THUNDER solutions will be validated in field conditions at the Demosite in Bulgaria where the practice of WHR from DC is not widely diffused thus boosting the market also in those areas. Deepened replicability assessment will be done and pre-feasibility analysis developed in 10 further Demosites across all over Europe. Co-design and training workshops will be organized at the replicability identified sites to promote stakeholders engagement and social awareness thus unlocking barriers and make it real THUNDER replication.

Keywords: waste heat recovery data centers seasonal storage thermochemical storage heat pumps district heating network
Seagrass Carbon cycling and Local Environmental Drivers (SCaLED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark,Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: CLOSED

Seagrass meadows have been identified as hotspots for carbon (C) sequestration, however, their full sequestration potential and its response to global change remains poorly understood and quantified. Large temporal and spatial variability of reported seagrass meadow carbon cycling rates limit our ability to robustly estimate seagrass meadows contribution to the global carbon cycle. With the SCaLED project, I will combine ecological, biogeochemical and modelling methods to develop a mechanistic understanding of seagrass meadow carbon cycling and sequestration, which will elucidate the observed variability, and thereby, enable robust present-day estimates and future forecasting of seagrass meadow carbon cycling. During the SCaLED project, I will receive training in the state-of-the-art Eddy Covariance technique, which I will apply alongside an ecological field survey, to quantify the dominant drivers of seagrass meadow carbon cycling. Using predictive and spatial modelling, I will make mechanistic regional forecasts of present-day seagrass carbon cycling, which will provide vital information for coastal managers and will help inform regional climate change policies. To further advance our mechanistic understanding and to forecast the future of seagrass meadow carbon cycling under climate change scenarios, I will conduct a secondment with ecological and biogeochemical modellers where I will develop an innovative dynamic seagrass carbon cycling model. The proposed interdisciplinary approach constitutes an unrivalled opportunity to increase our understanding of carbon cycling in the coastal zone and will provide me with a novel skillset that will set me up as an independent and innovative researcher.

Keywords: seagrass,blue carbon,carbon sequestration,climate change,ecosystem services,coastal ecosystems
COSMOlogy BEyond Standard Techniques: a program to exploit cosmic voids for precision cosmology (COSMOBEST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1411041.0
EU funding (EUR): 1411041.0
Participants: 1
Project status: SIGNED

Cosmology addresses the fundamental questions about our Universe: what is it made of? how does it evolve? Observations suggest that the Universe is undergoing an accelerated expansion---to explain it, cosmologists hypothesize the existence of a mysterious component: dark energy. Despite major recent advances in the field, up to now traditional methods in cosmological analysis have failed to provide a throughout understanding of dark energy. Large-scale surveys, mapping the distribution of billions of galaxies in the Universe, allow us to look back in time and encompass the era when dark energy rises: they are a powerful tool to address our fundamental questions. The next generation of surveys, and in particular the ESA Euclid mission, will map the Universe with high-quality measurements reaching unprecedented precision; they will sample the galaxy distribution in detail also in the emptier regions with fewer galaxies: voids. Void cosmology is in its golden age, and constitutes nowadays an increasingly active sector of galaxy clustering analysis: by measuring void properties we obtain stringent constraints on cosmological parameters. Voids allow to perform a novel and independent analysis of large-scale structure data, bringing us in the regime of COSMOlogy BEyond Standard Techniques. Voids are extremely sensitive to the properties of dark energy and neutrinos, and are a powerful tool to test general relativity in a new regime. COSMOBEST is an ambitious ERC program aiming to exploit voids as a novel and robust tool to shed light on the puzzles of modern cosmology. It capitalizes on the PI's wide experience in building void science in large collaborations, with a strong focus on calibration-free techniques and systematics control. With COSMOBEST I will lead void analysis from modern data, guaranteeing for Europe a worldwide leadership in delivering constraints on dark energy, neutrinos and general relativity from the next generation of surveys.

Keywords: cosmic voids,cosmological constraints,neutrinos,large scale surveys
Proof of Concept Prototype for Matching Applications on BELFORT Hardware (BELFORT MATCH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-03-01
End date: 2025-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The world has become one global village, strongly connected by the internet. Users, applications, and companies produce huge amounts of data. This data is mostly very private (health, financial, commercial data, etc.), requiring organizations to encrypt the data when storing or transmitting it. In Europe, fortunately, our GDPR regulations are very strict about this. On the other hand, many legitimate applications want to inspect or match the data with some database. Examples are matching encrypted names with a red list, providing privacy in financial transactions, or matching encrypted DNA snippets in a database. A solution to these conflicting requirements is offered by a new field in cryptography: computing on encrypted data (COED), and more specifically, fully homomorphic encryption (FHE). With FHE, data sits encrypted in the cloud. The data holder, i.e. the remote server, has no knowledge and is unable to decrypt the data. The magic of FHE is that operations can still be performed on the data, even though it remains encrypted. Unfortunately, it is currently too slow and too cumbersome to be used in practice. Within our ERC grant BELFORT, which focuses on "Hardware Acceleration for Computing on Encrypted Data", a novel hardware processor demonstrates orders of magnitude speed-up for essential operations in FHE. This POC aims to move from our academic proof of concept into a full-stack project integrated into open-source and commercial FHE libraries. We then plan to run a demo on an application of database look-up operations (‘keyword matching’), as they appear in many FHE applications. The ultimate goal of this project is to make operations on encrypted data efficient enough to perform them on the fly in a cloud setting. When a user formulates privacy-preserving encrypted queries to a server, it should be imperceptible that the operations are occurring in the encrypted domain. Being able to answer a query on the fly without delay will make this goal happen.
Game-changing uPAR-targeting dye for guiding surgical treatment of cancer (Fluoguide)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 14200000.0
EU funding (EUR): 14200000.0
Participants: 1
Project status: SIGNED

During operations, cancer surgery faces a critical challenge: distinguishing cancerous tissues from healthy ones. This issue leads to high local recurrence rates, with up to 90% in brain glioblastomas and 40% in neck cancer cases, due to incomplete removal of tumors. FluoGuide addresses this problem with FG001, a groundbreaking uPAR-targeting fluorescent imaging agent. FG001 illuminates cancer cells, providing real-time visualization up to 10 hours after injection. This allows surgeons to see even submillimeter-sized cancerous tissues, ensuring complete tumor resection and reducing the need for repeat surgeries. Our innovation offers unprecedented benefits, including improved precision in identifying and removing cancerous tissues, thereby significantly lowering recurrence rates and post-surgical complications. FG001’s deep tissue penetration (1-2 cm) and compatibility with existing surgical equipment make it a versatile solution applicable across various cancer types. This unique capability enhances patient outcomes and helps less experienced surgeons achieve successful operations. Moreover, by minimizing the need for additional surgeries, FG001 offers a cost-effective solution, easing the financial burden on healthcare systems and ensuring a sustainable approach to cancer treatment.

Keywords: cancer surgery,cancerous tissues,brain glioblastomas,incomplete tumor removal,upar targeting fluorescent imaging agent,real time visualization,tumor resection,submillimeter sized tissues
PHOTONIC AND ATOMIC QUBITS COMBINATION FOR UNPRECEDENTED QUANTUM COMPUTING EFFICIENCY (QSLABS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

Quantum computation has the potential to revolutionize many industries and contribute more than 1 trillion euros to the global economy. Large-scale, fault-tolerant quantum computers must be developed to unlock the huge potential of quantum computation. Current quantum computers have small numbers of qubits that face issues like qubits decoherence, control noise, and high energy consumption due to cryogenic cooling. These limitations hinder solving complex problems in fields like drug discovery, materials science, and cryptography. Without overcoming these challenges, Europe risks losing its competitive edge in the global quantum race, jeopardizing data security and innovation. Among all modalities, the photonic approach is the most promising towards achieving the goal of large-scale, fault-tolerant quantum computers. Despite their clear advantage, existing photonic quantum computation technologies are very expensive, complex and require significant real estate and energy power due to the probabilistic process for generating photonic entangled cluster states. QS Labs develops a revolutionary photonic quantum computer using a highly efficient, chip-scale Cavity Quantum Electrodynamics (C-QED) approach. Our solution combines photonic and atomic qubits and enables deterministic photons generation and entanglement process, providing four orders of magnitude efficiency gains over existing technologies. This approach facilitates the development of fault-tolerant quantum computers with millions of qubits, designed to fit within standard server rooms and operate at room temperature without the need for specialized infrastructure. A prototype Resource State Generator (RSG) unit is set to demonstrate the system's capabilities by 2025. QS Labs supports European technological sovereignty by delivering secure, EU-compliant quantum computers.

Keywords: quantum computing,fault tolerant,qubits,cavity quantum electrodynamics c qed,photonic qubits,deterministic photon generation,resource state generator rsg,scalability,energy efficiency
Neuromodulation of lymphatic function in intestinal Peyer's patches (EMPHATIC)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 1
Project status: SIGNED

The intestine hosts a vast neuronal system, a large population of immune cells, diverse microbiota, and a complex blood and lymphatic network. The intestinal lymphatic network comprises vessels and lymphoid organs, called Peyer’s patches (PPs), that together play important roles in dietary fat absorption, mucosal immune responses and trafficking of immune cells to the rest of the body. This intestinal immune cell trafficking is key in gut-to-organ communication, and its disruption leads to immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD). PP lymphatics are major routes for B- and T-cell egress from the intestine. Yet, little is known about the specific signals that modulate lymphatic control of immune cell trafficking. This project aims to explore the novel hypothesis that a synergistic interaction between neuronal signals and PP lymphatics modulates immunity and inflammation. Building on insights from single-cell RNA sequencing of PPs, I will investigate the role of the adrenergic receptor ADRA1B in lymphatic endothelial cells. This research will focus on characterizing the molecular changes in PP lymphatic cells and elucidating patterns of immune cell egress from the gut. Also, I will examine how adrenergic signalling influences PP lymphatic function and immune cell trafficking under inflammation, mimicking IBD condition. Lastly, I will extend these findings from mouse models to humans by defining the architecture and molecular signatures of human PP endothelial cells. This multidisciplinary project will integrate high-resolution imaging, intravital microscopy, and deep molecular profiling of both mouse and human endothelial cells to uncover this previously unexplored neuronal-lymphatic-immune axis. Given the physiological relevance of PP lymphatics as major intestinal immune gatekeepers, this work will provide novel insights into gut homeostasis and open new therapeutic avenues for treating immune-mediated inflammatory diseases.

Keywords: intestine neuronal innervation lymphatic endothelial cells peyer s patches immune cell trafficking
Philology as Science in 19th-Century Europe (PhiSci)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1464300.0
EU funding (EUR): 1464300.0
Participants: 1
Project status: SIGNED

Philology once defined what it meant to be scientific – and it may yet once again. Increasingly a broad array of scholars using digital methods cite the historical accomplishments of philology as a model for systematic study around unwieldy and heterogenous textual corpuses. Despite this renewed interest, there is still no systemic account for the huge range of activity and aegis, data and networks, that propelled philology to its status as a model or even the 'queen of science' in C19 Europe. In drawing on history of science, media studies, information studies and diverse textual methods, this project offers that holistic account of how and why philology as a 'science in the making' achieved such extraordinary success. It articulates the widely sought yet unachieved bridge that would permit rigorous interdisciplinary exchange between philology – its historical and contemporary iterations – and present-day endeavors in the fields of digital humanities, critical data studies, infrastructure studies and de/post-colonial studies. PhiSci takes philology seriously as a science and gives it the kind of treatment that has dominated history of science for the last generation. Pioneering a novel account of philology from the French Revolution to First World War, it pursues a central question: How did local ensembles of protocols, representation, instrumentation and cooperation consolidate into robust programs for the genesis of stable knowledge and knowledge communities? It gives special attention to heterogeneity and universality in key concepts and practices and to physical aspects like media and infrastructure: elements undervalued or rarely grasped in terms of their epistemic work for producing data, evidence and facts. PhiSci will thus explain how philology operated as a relational system that – in the diversity of its data and perpetual flux in its projects and personnel –projected unity that enabled it to wield a scientific authority greater than the sum of its parts.

Keywords: history of the humanities