Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enhancing cytotoxic T-lymphocyte tumour-fighting capacity through the modulation of metabolic pathways regulated by ZFP36/ZFP36L1 RNA-binding proteins (EnhancemenT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Cytotoxic CD8+ T-lymphocytes (CTLs) recognize and kill infected and malignant cells. Although CTLs recognize tumour-specific antigens, they often fail to limit cancer growth, as the cancer micro-environment rapidly suppresses their functionality. Therefore, there is the need to unveil new molecular circuits controlling CTL activation, the process through which T-cells proliferate and differentiate into an antigen-specific subpopulation with effector functions. In this way it will be possible to enhance CTL tumour-fighting capacity and improve the efficacy of immunotherapies, especially against solid cancers. My project will focus on how post-transcriptional regulation of metabolism modulates CTL activation. Post-transcriptional responses are fast and important for adaptation to rapidly changing environments. RNA-binding proteins (RBPs) are fundamental modulators of post-transcriptional regulation of many cellular processes, but less is known about how they regulate metabolism. By combining multi-omics approaches (i.e. proteomics, transcriptomics, metabolomics and in-vivo experiments) I will investigate how metabolic pathways in CTLs are modulated by specific RBPs. I will study how these RBPs regulate the stability and the translation of mRNAs encoding metabolic enzymes. Finally, I will control the expression of these RBPs in CAR-T cells (engineered T-lymphocytes used in cancer immunotherapies) to regulate metabolic pathways and enhance the in-vivo solid tumour-fighting capacity of these cells. Thus, my research will lay the groundwork for the identification of new methods to stimulate metabolism of tumour-infiltrating CTLs to enhance their functionality. My expertise in RNA-biology will complement the new skills I will learn from my host lab and collaborators, combining diverse disciplines to investigate fundamental immunological questions and apply my findings to in-vivo cancer immunotherapy.

Keywords: t lymphocytes,rna protein interactions,metabolism,post transcriptional regulation of gene expression,cancer immunotherapy
A structure-function analysis to discover how receptor conformations and interactions determine semaphorin-neuropilin-plexin signalling outputs. (FLEXINGPLEXIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 2083825.0
EU funding (EUR): 2083825.0
Participants: 1
Project status: SIGNED

During the development of a multicellular organism cell guidance proteins interact with their cognate cell surface receptors to guide cells to their correct location. Such functions continue to be essential in the adult to maintain tissue homeostasis. Semaphorins use plexins as their main receptors for signalling and the semaphorin and plexin families together constitute one of the largest and functionally diverse of the cell guidance systems in vertebrates. We have gained some insight into the architecture and interactions which trigger semaphorin-plexin signalling, but fundamental questions remain and some of the most puzzling, and of potential clinical importance, concern the mechanisms of action of the secreted class 3 semaphorins (Sema3s), and their (co-)receptors. Neuropilin co-receptors play pivotal roles for Sema3 function and have been implicated in context dependent switching of cell guidance signalling outputs. There is an urgent need for information on molecular mechanism to underpin the design and interpretation of studies into biological function and clinical pathology. To advance the field we will combine structural biology and cellular imaging based approaches with functional studies (in house and in collaboration). The research plan is sub-divided into three inter-related sections that aim to discover: 1. The structural determinants and mechanisms of action by which class 3 semaphorins exert differing effects on signalling. 2. The conformational state of the plexin ectodomain in different contexts and its contribution to signal outcome. 3. The mechanisms by which neuropilin binding can switch the outcomes of plexin signalling. Molecular level answers to the questions posed by semaphorin-neuropilin-plexin signalling will take us beyond the current state of the art, and impact on diverse disciplines, for example cellular immunology and developmental biology, as well as guiding the design of novel therapeutic agents.
Eco-friendly and customer-driven Sail plan optimisation service (EcoSail)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Cyprus,Sweden,Denmark,Anguilla,United Kingdom
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2018-11-01
End date: 2021-10-31
Duration (months): 36.0
Total project cost (EUR): 3903142.5
EU funding (EUR): 2986937.25
Participants: 6
Project status: CLOSED

The overall vision is to bring our patented EcoSail technology to full market maturation, to pilot the system and to arrive at its commercialisation as a new energy efficiency and cost-effective solution for the global maritime transport market. Our innovative route planning service will be a disruptive new market entry, reducing fuel consumption by at least 7%. EcoSail is rooted in the clear market-pull caused by the industry need to increase its cost efficiency and decrease environmental impacts. It is the result of several EU-funded R&D projects (SpaceNav, Navtronic & Sectronic) leading to a verified and demonstrated prototype (at TRL7) and confirming the commercial and economic viability. In these projects, the SMEs (OSM, GMS, ONL) developed a roadmap for technical improvements and a strategic business plan on entering the global maritime transport market. The EcoSail project approach is to execute these plans; technically advance EcoSail to TRL8 (WP1) and qualify the service in real-life operations to reach TRL9 (WP3). To support commercial viability, we will conduct a range of market maturation activities in WP4-5 and secure a dedicated EcoSail 'Training Academy' for future maritime masters, users and commercial staff (WP2). We bring together a strong consortium, the three lead SMEs with deep industry knowledge have teamed up with the world-class RTO, CHA, specialising in EO data and maritime training simulations, and a large offshore industrial target user (LAM), to successfully market launch and scale the ground-breaking EcoSail service platform. EcoSail will create a measurable consortium impact - as accumulated revenues of €87.1m for the 5-year post-project (2020-24), with accumulated gross profit of €44m and employment growth of 95 FTEs, and 80 FTEs in our value chain. Further, we will enable between €1.4bn to 2.7bn in reduced costs for our clients and decrease their CO2 emissions by 11m tonnes and their SOx emission by 0.3m tons.

Keywords: earth observation data,route optimisation,sail plan optimisation,energy efficiency,cost efficient,shipping,sail planning,remote sensing,maritime transportation,archived based human training
Engineered dissipation using symmetry-protected superconducting circuits (EDSP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-07-03
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Dissipation is fundamental to physical systems. In quantum mechanics, this manifests itself as energy decay and dephasing also known as quantum decoherence. In the field of quantum computing, decoherence is often relegated as a non-ideality of the physical system. However, dissipation and decoherence are a necessary for quantum information processing; allowing measurement, state preparation, and quantum error correction. I propose to explore engineered multi-photon dissipation processes using superconducting circuits. By extending the well-established ‘transmon qubit’ platform, this work will investigate the use of symmetry to prevent single-photon decay while allowing two-photon and four-photon decay events. Such a mechanism has immediate applications akin to trapped-ion technology for qubit state reset and resonance fluorescence readout. In addition, possible multi-mode dissipative processes provide a rich physics to explore more complex quantum phenomena in larger systems. This includes entanglement stabilization and the generation of decoherence-free subspaces.

Keywords: quantum computing,superconducting circuits
De-RISC: Dependable Real-time Infrastructure for Safety-critical Computer (De-RISC)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Spain,Sweden,France
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 3444625.0
EU funding (EUR): 2617937.5
Participants: 4
Project status: CLOSED

The De-RISC project addresses computer systems within the space and aviation domains. De-RISC – Dependable Real-time Infrastructure for Safety-critical Computer – is a proposed project where an international consortium will introduce a hardware and software platform based around the RISC-V ISA. The work proposed in this project is to productize a multi-core RISC-V system-on-chip design already owned by CG and to port the XtratuM hypervisor owned by FEN to that design to create a full platform consisting of hardware and software for future European developments within space and aeronautical applications. De-RISC brings critical features to the market that make it unique in front of the competition: (1) No US export restrictions: most existing products use US technology, thus subject to US export control. De-RISC’s IP core platform and software will not be subject to any US regulatory influence by building on RISC-V. (2) Multi-core interference mitigation concepts by BSC integrated in the RISC-V SoC and validated by TRT become a unique feature, and will provide a key advantage w.r.t. competitors by limiting drastically interference while preserving high-performance operation. (3) Portability: The proposed development will create a RISC-V HW/SW platform that can be implemented in FPGAs and application specific standard products. This provides an edge for integrators that can adapt their choice of implementation technology based on mission requirements. (4) Fault-tolerance concepts: The platform will be provided by companies with experience in the space domain and with heritage in design of fault-tolerant systems. (5) Future-proof selection for new platforms: New software products are not being ported to SPARC and PowerPC architectures. With an established vendor providing a RISC-V platform there are guarantees of continued support for the hardware platform while developments from the commercial domain for the RISC-V architecture can be leveraged over time.
Optimum, sustainable solution for seed drying and conservation (DryCoolerSeeds)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 1134500.0
EU funding (EUR): 794150.0
Participants: 1
Project status: CLOSED

The seed market will grow at a CAGR of 10.57% during the period 2014-2019 and is expected to increase to $24 billion from its current $14.52 billion value. Europe, with 3 of its countries (France, Germany and The Netherlands) as three of the top four seed exporters in the world includes nearly 7,200 seed companies and more than 50,000 employees. Production of high quality seeds can increase crop yield by 15-20%. Seed moisture content needs to be controlled to ensure high germination rates, thus high quality seeds. An optimum drying process with control of air’s relative humidity and temperature is needed to ensure harvested seed is at safe moisture content before storage or other purposes. Existing drying and cooling methods for seeds lack of control of these parameters, are not energy efficient and require high investment from farmers. Moreover, seed drying is one of the most energy consuming processes on farms, consuming as much energy as all field works together. With an efficient seed drying process, savings for farmers could be more than 50%. DryCoolerSeeds is able to dry and cool the seeds in a continuous monitored process with adaptation to climate variations, saving energy (99% of energy saved), time (2.5 less time needed than traditional dryers), ensuring the correct moisture content and temperature of seeds, resulting therefore in high quality seeds. Marcold’s technology is a step further in automation, simplification and costs savings (60% compared to traditional drying) being able to incorporate two different functions (drying and cooling) in a single machine surpassing the competition in the current market. The aim of the project is to build and demonstrate in real end user’s facilities our DryCoolerSeeds prototype adjusting the working parameters for effective conservation of seeds while ensuring a successful commercialization of the technology in Europe and Latin America that will drive Marcold into an exponential growth.

Keywords: seeds,dryer,energy saving,moisture,relative humidity,temperature,industry 4 0,high quality seeds and cereals
HOlistic Management of Emerging forest pests and Diseases (HOMED)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Italy,Australia,South Africa,Italy,Sweden,New Zealand,Switzerland,Finland,China,Bulgaria,France,France,France,Czechia,Netherlands,United States,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Research and approaches for emerging diseases and pests in plants and terrestrial livestock (H2020-SFS-2017-2, 2017)
Start date: 2018-10-01
End date: 2022-09-30
Duration (months): 48.0
Total project cost (EUR): 5754828.75
EU funding (EUR): 4999296.25
Participants: 23
Project status: SIGNED

HOMED will provide a full set of science-based, innovative practical methods and tools to assess and control emerging or invasive pests and pathogens threatening EU forests, following a holistic and multi-actor approach. Holistic because it will improve strategies of risk assessment and management by targeting the successive phases of invasion (transport, introduction, establishment, spread), and developing mitigation methods for each phase, i.e. prevention, detection and diagnosis, surveillance, eradication and control tools. Multi-actor because scientists will communicate with stakeholders all along the project; forest managers, biosecurity agencies, policy makers and environmental NGOs will be asked to express their needs and constrains and validate the tools as they develop. Innovation will be central, as the new tools for pest management will benefit from the most advanced technology, e.g. electronic sensors, hyper spectral cameras, the latest satellite constellation, high-throughput sequencing, unmanned aerial vehicles and artificial intelligence. As it is impossible to foresee the next invasive or emerging pest or pathogen, the overall approach will be generic. However, the new tools will be tested on four main types of pests and pathogens, i.e. foliar moths and needle blights causing tree growth loss, wood boring beetles and dieback fungi causing tree mortality. Prominent experts from the main forested countries of EU and the main regions of origin of invasive pests, e.g. North America, Australasia, China and South Africa, will contribute to the project, and ensure continuity and complementarity with past and current Euphresco and EU projects. By developing cost-effective, environmentally friendly tools for the prevention, detection and control, the project will reduce the tremendous economic losses caused by invasive forest pests and pathogens and help to maintain the critical ecosystem services provided by EU forests, including climate change mitigation.

Keywords: invasive non native pests and pathogens
French Mediterranean Support for Innovative SMEs (MED4INNO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: France,France,France,France
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 320501.25
EU funding (EUR): 320501.25
Participants: 6
Project status: CLOSED

MED4INNO Project proposal is an extension of the running MED2EUROPE Project financed under COSME Program for Enterprise Europe Network activity. The project covers the whole French Mediterranean area with 3 regions: Provence Alpes Côte d’Azur (PACA), Eastern part of Occitanie (ex LR) and Corsica (NUTS1 region FR7). The main objective of the project is to contribute to the increase of competitiveness of our most promising and innovative companies through 2 specific activities : - Enhancing Innovation Management Capacity action (EIMC): for SMEs with significant innovation activities and/or with a high growth potential for international development - Key Account Management action (KAM): for SMEs which are benefiting from European grants provided by the European Innovation Council (EIC Pilot) such as SME Instrument, Accelerator, Pathfinder FET or Fast Track to Innovation (FTI), which need in depth support to make them potential future European Champions.

Keywords: sme innovation growth acceleration diagnosis start ups
Allosteric modulation of G-protein Coupled Receptors conformational landscape (AlloGPCR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-08-31
Duration (months): 36.0
Total project cost (EUR): 246668.4
EU funding (EUR): 246668.4
Participants: 2
Project status: CLOSED

G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in eukaryotes. They bind a wide range of ligands, such as neurotransmitters, hormones, lipids and many others. GPCRs are the target of more than 30% of the drugs currently on the market, addressing neuropsychiatric, cardiovascular, pulmonary and metabolic disorders, cancer, obesity and AIDS. The functional versatility of GPCRs cannot be explained by a simple two-state model of activation considering only an active and an inactive state, as these receptors are highly dynamic and can explore a wide range of conformations. Some receptors of the family can signal in the absence of ligand (basal activity), and despite GPCR have been largely studied in the past years, little is known about their signal transduction mechanism. Apart from ligands and signalling partners, the structure and function of GPCRs can be modulated by lipids. In this context, our research will be divided in two steps: delineating the role of lipids on GPCR conformational landscape at the molecular scale (Aim1) and exploring an additional allosteric factor in line with lipid composition, the homo- and hetero-receptor oligomerisation (Aim2). To that purpose, we will apply an integrated, multidisciplinary analysis, to characterize protein dynamics under physiological conditions, with the GPCR reconstituted in model lipid systems or living cells, and in the presence of ligands, signalling and regulatory partners. We will use conformational probes to investigate the effect of lipids and other GPCRs on receptor dynamics, and correlate these findings with functional properties such as agonist binding and G protein coupling.

Keywords: g protein coupled receptors,lipids,membrane environment,allosteric modulation,conformational landscape,dynamics,pharmacology,fluorescence,single molecule techniques,deer
Handle with Science (HSciRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Romania,Romania,Romania,Romania,Romania,Romania,Romania
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-12-31
Duration (months): 20.0
Total project cost (EUR): 128000.0
EU funding (EUR): 128000.0
Participants: 13
Project status: CLOSED

HSCiRO - Handle with Science The general objective of the project is to promote the results of scientific research that supports people and humanity (vaccines, space technology, materials science, fundamental science). If we were to summarize all of this in an expression we would call it: Handle with Science in Romania -- HSciRO. We are trying to raise awareness on the science and technology of our everyday world, as well as the effort that the researchers put in making our lives better - from inventing technology that make our chores easier, to investigating what happens in the natural world and trying to find the cures to the diseases that still claim human lives. Moreover, as 2018 is the European Year of Cultural Heritage, this expression would gain an extra dimension, namely to speak inclusive of the history of rational and scientific thinking and the impact it had on European societies. HSciRO will be held in 6 major cities in Romania, considered to be the regional cultural and administrative capitals of our country: Bucharest, Iasi, Cluj, Timisoara, Sibiu, Craiova. The gravity point of all proposed activities is represented by various open-air activities, organized in an amusing manner by real scientists and students. Furthermore, we would like to stress the importance of scientific research for a modern society and to share information on major research infrastructures in Romania (e.g ELI project). European Research Area and the program Horizon2020 will be presented interactively at EU corners.

Keywords: researcher,science,technologies,experiments