Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mcodaq is a new benchtop instrument for fraud detection in cosmetics, perfumes, candles and other consumer products, based on NMR and used by technicians without specific analytical chemistry skills (MCodaq)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

What: Fully automated, multiplexed, turnkey commercial routine system for analysis and confirmation of principal components for fraud detection in cosmetics, perfumes, candles and other consumer products, based on NMR (Nuclear Magnetic Resonance) technology and used by laboratory technicians without specific analytical chemistry skills. Why: Latest developments in NMR make it suitable, for the first time, as a routine QC technique to be used in Quality Assurance laboratories. Latest room temperature benchtop NMR instruments have the necessary sensitivity, resolution, robustness, operation simplicity and low operating cost, when combined with software implementation of latest innovations in NMR signal processing, analysis, machine learning and chemometrics. Users: Global retailers (e.g., Inditex SA, El Corte Ingles, Primark, Ulta, Sephora, etc. – Inditex declaration of interest in attachment) and the network of global, regional and local analytical contract laboratories used by the industry (e.g., SGS, TÜV SÜD, Bureau Veritas, and Underwriters Laboratory) Who: The proposed members of a Phase 2 consortium are the leading benchtop NMR manufacturer (Magritek GmbH, Aachen, Germany), the leading NMR software developer (Mestrelab Research SL, Santiago de Compostela, Spain) and an experienced method development analytical lab (AMSLab, Lugo, Spain). We have advanced prototypes of the hardware and software needed to deliver the proposed solution, and deep understanding of the needs of Inditex SA. Aim: The phase 1 project would seek to generalise this understanding to the rest of the market and to decide the most valuable turnkey solutions to be implemented in a fully automated finished product. Success of phase 1 would result in a phase 2 application in July, to fund the development of a final market ready system.

Keywords: fraud analysis,analytical chemistry
Global Production Networks and Macroeconomic Interdependence (GLOBALMACRO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2022-04-30
Duration (months): 60.0
Total project cost (EUR): 1381250.0
EU funding (EUR): 1381250.0
Participants: 1
Project status: CLOSED

Researchers and policymakers alike have highlighted the potential efficiency gains of a global production structure. However, such linkages also raise the possibility of risks. This proposal tackles both empirical and theoretical challenges in incorporating the microeconomic structure of trade and international production networks in the study of the propagation of shocks internationally, and their impact on macroeconomic interdependence. Using newly constructed micro-level datasets, I provide quantitative analysis of the importance of the linkages in multicountry general equilibrium models of trade. First, using firm export and imported-input linkages, I provide a novel model-based estimation strategy to identify the role of country and firm-level shocks, and the implications of these estimates for the transmission of shocks across borders. By using structural trade models to estimate shocks at the firm level and studying the implications for the transmission of shocks across borders, I help bridge the micro-macro nexus in international economics. Second, I take an even more granular focus by studying the role of firm-to-firm production linkages in transmitting shocks across countries. To do so, I exploit a novel matching procedure between a country’s administrative dataset and cross-country firm-level data. I further build on these data by adding in domestic bank-firm relationships. This strategy allows for the study of how financial shocks are exported abroad via firms’ trade and multinational linkages. Third, I incorporate the insights from the empirical work into a full-scale multicountry general equilibrium model of trade, which allows for firm-level heterogeneity and microeconomic and macroeconomics shocks. I use the model for a quantitative study of the cross-country transmission of the different shocks via trade. This allows me to perform counterfactuals and examine the impact of policies, such as how opening to trade impacts macroeconomic interdependence.

Keywords: macroeconomic interdependence,propagation of shocks,production networks,international trade,large firms
Annular Instabilities and Transient Phenomena in Gas Turbine Combustors (ANNULIGhT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Switzerland,Switzerland,Norway,France,France,France,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-10-01
End date: 2022-01-31
Duration (months): 52.0
Total project cost (EUR): 3974482.8
EU funding (EUR): 3974482.8
Participants: 10
Project status: CLOSED

The gas turbine industry is a vital driver of innovation, economic growth, jobs, trade and mobility in the EU in both the aviation and power generation sectors. It is a multi-billion Euro high-technology industry whose future competitiveness depends on a new generation of creative engineers with multi-disciplinary skills who can accelerate the development of new innovations needed for flexible, efficient power generation and sustainable aviation. Low-emission gas turbines are confronted with unsteady combustion problems often only discovered late into development or in service because our scientific and understanding is insufficient to predict them at the design stage. For reasons of cost and simplicity, we have been trying to solve unsteady combustion problems by studying them in single (or multiple) sectors. The lack of success of this approach is a striking gap in our community and is hindering innovation. ANNULIGhT will break this paradigm by bringing together academic and industry leaders to provide a new generation of engineers with an innovative, structured, multi-disciplinary training programme combining cutting-edge theory, computational and experimental methods that exclusively focuses on annular combustion chambers as found in real gas turbines. ANNULIGhT presents a new and innovative research and training methodologies that exploits three revolutions that have recently taken place in the field of unsteady combustion; i) new computational methods based on Large Eddy Simulations applied to full annular chambers that can reproduce phenomena observed in real systems, ii) new annular combustion facilities enabling these phenomena to be studied in detail in the laboratory, and (iii) new high-speed imaging diagnostics which gives time-resolved information. ANNULIGhT aims to deliver a new generation of engineers to develop the innovations needed for low-emission technologies and increase the competitiveness of the European gas turbine industry.

Keywords: gas turbine combustion,annular combustion chambers,combustion instabilities,combustion dynamics,passive control,ignition,altitude relight,large eddy simulations,advanced laser diagnostics
A novel affordable, portable and autonomous wastewater treatment unit for the agriculture industry (WasteWater Science)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Malta
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

WasteWater Science Ltd is a Maltese fast growing SME that has a clear business objective to produce wastewater recovery products and to reclaim the nutrients in the wastewater for productive use. Our company intends to commercialise a novel affordable, portable and autonomous wastewater treatments units and make the business more profitable and sustainable through a novel business model. We are challenging the status quo of organic waste disposal by offering producers a novel and greener alternative that is more convenient, eliminates disposal and hauling costs and in countries where water is a scarce and expensive resource it recovers water from organic waste, thus reducing significantly their water bills. 70% of the world’s water is used in the agricultural sector. Our novel product creates added value from waste and by-products generated on farm and saves the farmer 85% of costs. Our company has diversified from Big Players and has created an untapped niche market in the $1 Billion wastewater treatment industry. Our solution provides a high economic impact to the global agriculture sector. We foresee that our innovative product will generate over €5 Million to our annual revenue by 2020, increase our annual profits by 10% and grow direct employment by 1150% by 2020. Phase 1 of this innovative project is to carry out an elaborate Feasibility Study and Business Plan to get this product from TRL6 to TRL9 and commercialise it in the international market

Keywords: waste water treatment,organic waste,value from waste,sustainable and competitive agriculture
Identifying Zymoseptoria tritici effectors that suppress wheat immune responses (Zuppressors)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

I will use my MSCA-IF in the Stukenbrock Lab to dissect the molecular interactions between the fungal pathogen, Zymoseptoria tritici, and its host plant, wheat. Despite being the most devastating fungal wheat disease in Europe, little is known about the molecular mechanisms used by Z. tritici to cause disease. I propose to undertake a project that will use my expertise in molecular biology, combined with the Stukenbrock Lab's expertise in fungal genomics and evolution, to build a better understanding of how Z. tritici is able to evade host immune defences in order to grow, develop and, ultimately, induce disease symptoms. Plant pathogens use secreted proteins, described as effectors, to suppress host defences and/or alter host metabolism. However, few effectors from Z. tritici have been characterised. I aim to identify effectors that are used by Z. tritici to suppress wheat immune systems. To select effector candidates, I will use the Stukenbrock Lab's Zymoseptoria genomic resources to compare the variation in effector complements among Z. tritici and its closely related sister species. Z. tritici can infect wheat and not wild grass species. Inversely, Z. tritici's sister species infect wild grasses, but cannot infect wheat. Therefore, I hypothesise that effectors shared among all of these species are candidates as suppressors of conserved plant immune systems, whereas, effectors unique to Z. tritici, and conserved among all isolates of this fungus, are likely involved in host specialisation. I will screen the former set of effector candidates for their ability to suppress BAK1-dependent immune responses (an immune pathway conserved among a divergent range of plant species). I will knock-out the genes encoding the latter set of effectors, and will screen whether the virulence of the resulting mutants is reduced. Combined, these two approaches will help assign functions to more Z. tritici effectors and, thereby, develop new insights into this devastating disease.

Keywords: effectors,immune receptor suppression,fungi,zymoseptoria tritici,host specificity,wheat,plant pathogen interactions
UROthelial carcinoma Biomarker based diagnostic tEST (URO-BEST)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Bladder cancer is among the five most common malignancies worldwide: more than 380.000 new cases are diagnosed yearly. If detected early, 5-year survival is high (94%),but >70% of diagnosed patients will relapse within this period. The current gold standard diagnostic tool is combined cytology and cystoscopy which is costly and highly invasive requiring transurethral access and presenting the risk of important complications. Due to high relapse rates, surveillance requires frequent cystoscopies, averaging 13 controls per patient after initial diagnosis. Hence, bladder cancer is one of the costliest cancers to treat and monitor. Only in the USA, Europe and Japan, more than 4.5 million cystoscopies are conducted yearly, 40% for 1st diagnosis and 60% for surveillance, at a cost near to $2 billion to healthcare providers. Urologists believe that an opportunity exists to reduce the number of SURVEILLANCE cystoscopies with a reliable, cost-effective, robust, easy-to-perfom and non-invasive assay. URO-BEST addresses this unmet need. Based on signatures of 2, 5,10 and 12 differentially-expressed genes, this test has been clinically validated in a multicenter international study on 525 urine samples demonstrating 81% sensitivity and 91% specificity in discriminating cases vs. healhty patients for first diagnosis, figures comparable to that of the gold standard and superior to other existing molecular diagnostic products (Urovysion, NMP22, BTA Stat). We estimate the current market for bladder cancer biomarker based tests at greater than > $200million. Fina Biotech has filed European and PCT patent applications protecting the invention in 2013. Fina Biotech aims to clinically validate the diagnostic performance of the genetic signatures in patients under SURVEILLANCE for its launch to the market: advance ongoing discussions with potential partners for global licensing,increase urologists awareness and secure freedom to operate.

Keywords: bladder cancer,molecular biomarker,gene signature,diagnosis,surveillance,cystoscopy,cytology,urine,urologist,healthcare provider,clinical validation,licensing
Rates of Interglacial Sea-level Change, and Responses (RISeR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1997680.5
EU funding (EUR): 1978233.0
Participants: 2
Project status: SIGNED

Global sea-level rise is one of our greatest environmental challenges and is predicted to continue for hundreds of years, even if global greenhouse-gas emissions are stopped immediately. However, the range, rates and responses to sea-level rise beyond 2100 are poorly understood. Current models that project sea-level rise centuries into the future have large uncertainties because the recent observations upon which they are based, encompass too limited a range of climate variability. Therefore, it is crucial to turn to the geological record where there are large-scale changes in climate. Global temperatures during the Last Interglacial were ~1oC warmer than pre-industrial values and 3-5oC warmer at the poles (a pattern similar to that predicted in the coming centuries), and global sea level was 6-9 m higher, far above that experienced in human memory. Through the RISeR project, I will lead a step-change advance in our understanding of the magnitude, rates and drivers of sea-level change during the Last Interglacial, to inform both global and regional sea-level projections beyond 2100. Specifically I will: 1. Develop new palaeoenvironmental reconstructions of Last Interglacial sea-level change from northwest Europe; 2. Provide the first ever chronological constraints on the timing, and therefore rates, of relative sea-level change that occurred in northwest Europe during the Last Interglacial; 3. Use state-of-the-art numerical modelling to distinguish the relative contributions of the Greenland and Antarctica ice sheets to global sea-level rise during the Last Interglacial; 4. Provide estimates of the land areas and exposed populations in northwest Europe at risk of inundation by long-term (2100+) sea-level rise, providing high-end scenarios critical for coastal-risk management practice. These ambitious objectives will result in a state-of-the-art integrated study of the most appropriate analogue for a critical global environmental challenge; future sea-level rise.

Keywords: sea level change,ice sheets
Indo-European Consortium for Next Generation Influenza Vaccine Innovation (INCENTIVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: India,Spain,Germany,Germany,Switzerland,Norway,Norway,Belgium,Belgium,France,France,Netherlands,United States,Netherlands
Call: Towards a next generation influenza vaccine to protect citizens worldwide – an EU-India collaboration (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-08-01
End date: 2025-07-31
Duration (months): 60.0
Total project cost (EUR): 19965992.5
EU funding (EUR): 9974293.75
Participants: 21
Project status: SIGNED

The highly integrated INCENTIVE consortium represents true partnership between Indian and European/US groups that addresses the global health and economic challenge posed by influenza infections, to reduce the worldwide burden resulting from outbreaks. INCENTIVE’s strategic goals are to provide seminal knowledge on the underlying mechanisms of poor responsiveness to influenza vaccines in vulnerable individuals and advance the development of two next generation universal influenza vaccines. This is achieved by pursing the following specific objectives: 1) address the current knowledge gap by performing comprehensive immunome profiling of responders and non-responders to licensed influenza vaccines in infants, children, adults and elderly in parallel phase IV trials in Europe and India to identify the underlying mechanisms of vaccine responsiveness in different vulnerable populations and ethnical groups; 2) advance the development of two next generation universal vaccines, including an antigen presenting cell-targeted nucleic acid vaccine up to proof-of-concept for vaccine efficacy in non-human primates, and a computationally-derived second generation COBRA (Computationally-Optimized Broadly-Reactive Antigens) vaccine up to clinical development, comprising a phase I trial in Europe, a phase II trial in India and efficacy studies using an influenza controlled human challenge model; 3) identify predictive biomarkers of responsiveness to vaccination to develop new diagnostics; 4) implement comprehensive technology transfer and harmonization activities for immunological analysis and data integration; and 5) perform a health systems and investment analysis, and discrete choice experiments to assess the suitability of the developed technologies for low- and middle-income countries and to identify potential downstream constraints that might affect uptake by health care systems.

Keywords: preclinical validation,human trials,immune profiling,immune monitoring,responsiveness,human challenge,vulnerable,technology transfer,data integration,health economics
Planetary RObots Deployed for Assembly and Construction Tasks (PRO-ACT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Poland,Poland,Belgium,France,United Kingdom,United Kingdom,United Kingdom
Call: SRC – Space robotics technologies (H2020-SPACE-2018, 2018)
Start date: 2019-02-01
End date: 2021-04-30
Duration (months): 27.0
Total project cost (EUR): 3100000.0
EU funding (EUR): 3100000.0
Participants: 11
Project status: CLOSED

The proposal addresses the establishment, with the support of mobile robotic platforms, of a precursor lunar base with essential capabilities in preparation to commercial exploitation of in-situ resources by assembling an ISRU resource extraction and utilization system will be essential for the establishment of future human settlement. It will in particular include the extraction of oxygen from regolith to serve as oxidizer for fuel and for artificial atmosphere generation within habitats, and 3D printing of relevant structures using regolith (with or without adjuvant, depending on printing strategy) for construction purpose – e.g. tiles for landing pad and roads, panels for berms, elements for shelters. The primary objective of PRO-ACT is to implement and demonstrate multi-robot cooperation capabilities in a moon construction context, relying on, extending and integrating the outcomes of OG1, 2, 3, 4 and 5. Accordingly PRO-ACT will: - Review, extend and integrate ESROCOS, ERGO, InFuse, I3DS and SIROM outcomes as part of a comprehensive multi-robot system, in a meaningful moon construction scenario. - Develop robust multi-robot cooperation capabilities allowing joint interventions (including navigation in close vicinity and joint manipulation actions) in mixed structured / unstructured environment. Make the capabilities available within a CREW module, integrated along with ERGO, InFuse and ESROCOS. - Perform the customization of existing mobile robotic platforms and prepare facilities (moon analogue) for performing tests and demonstrations in a selection of relevant, partially representative scenarios of moon construction activities in relation to (1) ISRU capabilities establishment and (2) preparing dust mitigation surfaces (3) assembling and deploying a gantry/3D printer. As a baseline, TRL 4 to 5 is aimed at (depending on scenarios subparts). - Perform needed tests and demonstrations in Lunar analogues to validate the newly developed capabilities.