Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultrasensitive nanoplatform enabling on-site and continuous water pollutant detection based on analyte fingerprinting. (WATERsense)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Czechia,Austria,Denmark
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 2999205.25
EU funding (EUR): 2999205.0
Participants: 6
Project status: SIGNED

Thousands of chemical substances are currently produced by humans for various purposes with a substantial portion leaking into the environment. The European Commission has already defined the following two priorities: protecting our biodiversity and ecosystems, and reducing air, water and soil pollution within the environment and oceans actions included in the recently approved European Green Deal programme. WATERsense aims at developing a new concept and respective prototype for universal vibrational spectroscopy-based analyte fingerprinting that is performed in continuous manner and enables sensitive monitoring of analytes. To attain this main objective we will fabricate magneto-plasmonic nano-objects that will carry the analytes to be detected. These nanocarriers will flow through a micro/nanofluidic chip system where they will be trapped, docked and subsequently optically probed by Raman spectroscopy. WATERsense will target the following novel approaches: (i) Molecular Trapping: Controlled analyte (pollutant molecule) loading within the nanocarriers. (ii) Tracking and Transport: Manipulation of a single nanoparticle-carrier in a nano-sized fluidic chamber. (iii) Detection: Ultrasensitive analyte detection up to 6 orders of magnitude below the required concentration range. (iv) Analysis: Quantitative, extremely fast and continuous pollution detection and real-time analysis based on molecular fingerprinting using machine learning algorithms trained on large datasets. WATERsense technology will enable the real-time tracking of concentration changes of a set of important pollutants that represent a danger for humankind and environment, revolutionising the field of environmental protection. In the long run, the WATERsense sensing concept can also be extended to sampling in the food industry, reagent sampling in the pharmaceutical branch, detection of biomarkers for molecular diagnostics and examination of fundamental processes in hydrology, geology and biology.

Keywords: magneto plasmonic nanoparticles,surface functionalization,plasmonic hotspots,sers,nanofluidics,water quality monitoring,nanophotonics
Utilization of Marginal lands for growing sustainable industrial crops and developing innovative bio-based products (MIDAS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Greece,Italy,Brazil,Portugal,Hungary,Spain,Finland,Serbia,Poland,Czechia,France,Canada,Netherlands,Germany
Call: Marginal lands and climate-resilient and biodiversity-friendly crops for sustainable industrial feedstocks and related value chains (HORIZON-CL6-2022-CIRCBIO-01, 2022)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 7839775.0
EU funding (EUR): 6999100.0
Participants: 29
Project status: SIGNED

MIDAS aims to develop, evaluate and optimize sustainable low-ILUC feedstock by developing selected industrial crops and cropping systems on European marginal agricultural land in a climate-resilient and biodiversity-friendly way to support feasible bio-based value chains. Mapping of the actual and future marginal lands that may be certified as low-ILUC, including current and future expectations on soil erosion and water stress as well as biodiversity challenges and potentials, ecosystem services, and guidelines for enhancing co-benefits will improve understanding of the available marginal land for “low-ILUC” biomass production. Selected industrial crops, already adapted to marginal lands, will be optimized through modern biotechnology tools - particularly for water-use efficiency - and through tailored agronomic practices towards improved resource efficiency. Case studies of innovative farming systems (intercropping, agroforestry) established on marginal land at farm level will improve harvesting solutions, biodiversity data and guidelines while relevant actors (farming community, bio-based industry & academia) will be engaged through Regional Advisory Groups. From the produced biomass innovative bio-based products (biochemicals, composites, and elastomers) will be developed, following the biorefinery and the circular use concept. Potential biomass-to-product(s) pathways will be identified, leading to value chain/ web concepts that will be assessed for sustainability and will produce a multi-criteria tool for the design of sustainable bio-based value webs while enhancing regional biodiversity. Finally business plans to foster circularity at farm level by engaging the farming community, industrial actors and academia through the projects’ Case Studies will be developed. Moreover, through international cooperation (Brazil, Canada) on crops, cropping systems and bio based products MIDAS allows best practices exchange and contributes to win-win scenarios development.

Keywords: industrial crops,marginal land,low iluc feedstock,cropping systems,biobased products,biodiversity
European Centre of Excellence on Inclusive Gender Equality in Research & Innovation: Creating Knowledge & Engaging in Collaborative Action (INSPIRE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Denmark,Poland,Costa Rica,Hungary,Netherlands,Germany,Belgium,Slovenia,Greece,Norway
Call: Centre of excellence on inclusive gender equality in Research & Innovation (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 4996761.25
EU funding (EUR): 4996758.0
Participants: 15
Project status: SIGNED

INSPIRE aims to be Europe's sustainable centre of excellence, globally renowned for the quality of its research and analysis produced on inclusive gender equality in research and innovation. It brings together cutting-edge knowledge, ambitious policy approaches, and innovative practices to provide a gateway for scholars, equality experts, practitioners and trainers to connect and share resources, co-create new ones, and link strategically with public and private institutions to benefit the European Research Area. INSPIRE's ambitious research programme develops new, relevant indicators for inclusive GEP development, conducts a GEP monitoring survey throughout Europe whilst identifies key configurations of GEP success and failure. It will fill key knowledge gaps as a result of case studies on intersectional policies, whilst identifying promising practices in gendered regional innovation policy. INSPIRE strengthens the evidence base for informed policymaking and meaningfully engages decision-makers in policy and R&I funding for shaping the future. INSPIRE counts on 4 Knowledge & Support Hubs (KSHs) led by leading academics and renowned practitioners throughout Europe to develop cutting edge knowledge on sustaining change, widening participation, intersectionality and fostering innovation and change in the private sector. These KSHs will provide support to 12 communities of practice (involving more than 95 institutions) to facilitate GEP implementation and foster mutual support for the co-development of innovative practices, customised training, and pan-European data collection. INSPIRE will reduce disparities across Member States and strengthen the ERA through its distributed approach, spreading knowledge, know-how and new opportunities for more open and inclusive research and innovation across Europe.

Keywords: research and innovation,intersectionality,innovation and the private sector
Biosynthesis of resveratrol by co-culturing engineered Yarrowia lipolytica strains (YORES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Resveratrol (3,4',5-trihydroxystilbene) and its derivatives (e.g., pterostilbene, piceatannol, and viniferin) are naturally occurring compounds found in plants and have various medicinal properties, including anti-inflammatory, antimicrobial, anti-cancer and many other activities. Therefore, they are commercialised as components of many medicines, nutritional supplements, healthy foods, and cosmetics. However, plants typically have low concentrations of resveratrol (e.g., 5.1 μg/g in peanut and 3.9 mg/g in Rheum rhaponticum). Extracting resveratrol from plants is a traditional method with notable drawbacks, including long growth times (several years), high costs, low yields, land and labor waste, and pollution of the environment. The chemical synthesis of resveratrol involves complex steps, uses hazardous solvents, and generates toxic byproducts. Due to these reasons, biotechnological production of resveratrol by recombinant microorganisms is a promising strategy to solve the above issues. The current production of resveratrol synthesised by mono-culturing yeast remains relatively low, with productions in shake flasks being less than 1 g/L. Microbial co-culture is a cooperation strategy where microorganisms survive by feeding on the metabolic products of neighbors. This approach alleviates the significant metabolic burden associated with engineering a single strain to handle the entire biosynthetic pathway of metabolites. It promises to increase final production compared to the mono-culture. This proposed study relates to a novel approach in resveratrol biosynthesis by Y. lipolytica, which will address a critical question in today's resveratrol biosynthesis research: can the co-culture of Y. lipolytica engineered strains using lignocellulose as a sustainable carbon source significantly improve resveratrol production and promote the industrialisation of resveratrol biosynthesis in Europe?

Keywords: synthetic biology,microbial co culture,yarrowia lipolytica,resveratrol biosynthesis,lignocellulose,in situ extraction
Determining Genetic Bases of Differential Response to Antipsychotics Using Patient-Derived Neurons (MapGen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 307939.68
EU funding (EUR): 307939.68
Participants: 2
Project status: CLOSED

Schizophrenia (SCZ) affects 20 million people worldwide and antipsychotics remain the only effective pharmacological intervention. However, one-third of people with SCZ do not respond to first-line antipsychotic drugs. In the absence of clinical biomarkers to stratify SCZ subtypes, all individuals receive the same initial intervention, and it takes >4 years on average before people with resistant forms of the condition receive suitable treatment. My overall aim is to unravel the pre-symptomatic cell-type-specific genetic circuits contributing to differential treatment response in SCZ. To achieve my aim I will use an interdisciplinary approach that improves my technical and soft skills and further extends my international network through a two-year stay at Yale University, and three months secondment at Harvard Medical School. During the return phase, I will establish myself as an independent researcher and a suitable candidate for leadership of a to-be-established stem cell lab at the host institute. Objectives are (O1) to identify cell-type-specific neuronal pathways associated with distinct neurotransmission imbalances in each SCZ subgroup using a human-based neurodevelopmental model. (O2) To determine the functional link between SCZ-associated risk variants and response to antipsychotics. Method: I will couple advanced stem cell models (region-specific brain organoids) with single-cell RNA sequencing to generate cell-type-specific transcriptomic profiles of patient-derived brain organoids from treatment-responsive and treatment-resistant forms of SCZ. I will integrate the potential risk variants from SCZ-GWAS and use published functional genomics data to determine the genetic pathways and associated regulators implicated in the etiopathophysiology of differential response to antipsychotics. Impact: identify distinct genetic makeup for each SCZ subgroup to serve as potential predictive biomarkers and points of therapeutic intervention.

Keywords: schizophrenia,treatment resistance,organoids,hipsc,single cell rnaseq
Multicore Fibers for Future Quantum Networks (QCORE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Amid global uncertainties and evolving geopolitical tensions, ensuring the secrecy of critical communications and safeguarding European technological sovereignty has become paramount. The vulnerabilities of traditional encryption methods have already been exposed and there are indications that certain countries are already employing the "harvest now, decrypt later" principle, emphasizing the urgency for enhanced digital security measures. Quantum Key Distribution (QKD) offers a revolutionary approach to secure key exchange, harnessing the principles of quantum mechanics to provide perfect secrecy. However, the widespread adoption of QKD still faces significant obstacles, including compatibility issues with existing telecom infrastructure and the current low secure key rates (SKR). Recent manufacturing advancements in multicore fibers (MCF) place them as a compelling answer, as they offer a host of advantages. For instance, they provide support for spatial-division multiplexing, enabling to reach the SKR capacity demands; they facilitate the integration of quantum and classical networks within a single fiber with a smaller footprint compared to bundles of standard optical fibers; and they enable the distribution of entangled photons, opening the door for multiparty communication. With these capabilities, MCFs assume a pivotal role in constructing the foundation of the future quantum network. This research explores the potential of MCF for next-generation quantum networks. It aims to introduce and implement a novel space- and wavelength-division multiplexing scheme for high-dimensional (HD) QKD, offering an increased channel capacity and enhanced security. Further, this project studies the distribution of entangled photons over a deployed MCF link and seeks to perform QKD between multiple users. Additionally, it aims to explore the coexistence of quantum information along with real-valued internet traffic.

Keywords: quantum key distribution,multicore fibers,entanglement distribution,telecom infrastructure
Interrogating basal ganglia reinforcement with deep brain stimulation in Parkinson’s disease. (ReinforceBG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1499580.0
EU funding (EUR): 1499580.0
Participants: 1
Project status: SIGNED

Dopamine and the basal ganglia have been conserved over more than 500 million years of evolution. They are fundamental to animal and human behaviour. Parkinson’s disease (PD) is associated with loss of dopaminergic innervation to the basal ganglia. Over 6 million people suffer from the debilitating symptoms of PD that span disturbance of emotion, cognition and movement. There is a pressing need to understand the pathogenesis of these symptoms, but an integrated account of dopamine and basal ganglia function is lacking. This constitutes a significant roadblock to scientific and therapeutic advances. To overcome this roadblock, ReinforceBG poses the novel unconventional hypothesis that loss of dopamine in PD does not impair movement per se but leads to chronic negative reinforcement of neural population dynamics. Conversely, in the healthy state, transient dopamine signals may stabilize cortex–basal ganglia activity to facilitate reentry and refinement of cortical output. To address this hypothesis, ReinforceBG will combine invasive electrocorticography and local field potential recordings with closed-loop deep brain stimulation in PD patients. Aim 1 will investigate how basal ganglia pathways coordinate neuromuscular adaptation. Aim 2 will shed light on basal ganglia reinforcement in multiple behavioural domains, including movement, gait, speech, and spatial navigation in virtual reality. Aim 3 will develop a neuroprosthetic brain-computer interface that aims to modulate basal ganglia reinforcement. ReinforceBG deviates from outdated models on pro- vs. antikinetic “Go” and “NoGo” pathways and promises a holistic-reinforcement centred view of basal ganglia function. It will leverage the unprecedented spatiotemporal precision of neuromodulation for the development of an innovative brain circuit intervention that modulates neural reinforcement in real time. This opens new horizons for the interdisciplinary treatment of brain disorders affecting the dopaminergic system.

Keywords: neuromodulation,electroencephalography,parkinson s disease,neurosurgery,brain computer interface
Pathways towards a fair, inclusive and innovative Data Economy for Sustainable Food Systems (Data4Food2030)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Netherlands,Greece,France,Belgium,Germany,Luxembourg,Latvia,Poland,Spain,Slovenia,Czechia,Finland
Call: Mapping and improving the data economy for food systems (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 9999416.25
EU funding (EUR): 9999416.25
Participants: 25
Project status: SIGNED

The digital transformation of food systems has entered a twilight zone: data-driven innovations have proven to be promising, but it is still unclear how to upscale adoption and have broader acceptance. The Data4Food2030 project aims to improve the data economy for food systems (DE4FS) by expanding its definition, mapping its development, performance and impact to create new insights and opportunities. This contributes to a more competitive and sustainable food system in the EU and supports implementation and adaptation of relevant policies such as a Digital Single Market, Green Deal and the Common Agricultural Policy. Data4Food2030 is a 4-year project that aims to 1) enlarge the knowledge base and insight into the DE4FS, 2) develop a system that monitors and evaluates the development, performance and impact of the DE4FS on relevant EU policies 3) identify drivers and barriers and turn these into opportunities, recommendations and solutions, 4) test solutions and evaluate recommendations in case studies and through stakeholder dialogues and 5) provide future scenarios and a roadmap and sustain the monitoring system to support policy development and accelerate the desired future state of the DE4FS. Data4Food2030’s approach is targeted at an improved future state of the DE4FS from which clear design principles, recommendations and solutions are derived for improving and adapting policies and practices at public and private level. As an essential part of the project, stakeholders are deeply engaged to provide input to various DE4FS concepts and evaluate several project outcomes to increase the impact of the project. Nine case studies provide real-life examples of the DE4FS at micro- and meso-economic level, deploying data and technologies, which are used for mapping and improvement to promote data-enabled business models. In this way, Data4Food2030 creates credible pathways to navigate properly through the twilight zone towards a fair, inclusive and innovative DE4FS.

Keywords: food systems,fair,inclusive,data valorisation,agri food data economy,data re use,interoperability,sustainability,df4fs,data4food2030,data driven innovations,data sharing,data economy