Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pilot experiences for improving gender equality in research organisations (R-I PEERS)

Framework: Horizon 2020 — Science with and for Society
Programme: Promote gender equality in particular by supporting structural change in the organisation of research institutions and in the content and design of research activities
Action type: Coordination and support actions
Countries involved: Italy,Israel,Spain,Italy,Cyprus,Belgium,Tunisia,Greece,Slovenia
Call: Support to research organisations to implement gender equality plans (H2020-SwafS-2017-1, 2017)
Start date: 2018-05-01
End date: 2022-08-31
Duration (months): 52.0
Total project cost (EUR): 2029351.25
EU funding (EUR): 2029351.25
Participants: 11
Project status: CLOSED

The R&I PEERS project will be based on the concept of gender equality, that can be expressed as “women and men enjoy the same status and have equal opportunity to realize their full human rights and potential to contribute to national, political, economic, social and cultural development, and to benefit from the results”. The R&I PEERS project aims at creating and validating pilot experiences aiming at disrupting the gender-biased approach and those unconscious rules that limit the participation and the career of women in research and innovation in the Mediterranean Area. To do so, we will leverage on the synergies of structured dialogues and women’ empowerment through skills and entrepreneurial perspective of research and innovation. The project objectives are: 1. Implementation and improvement of 7 GEPs in R&I related organisations 2. Smooth the gap of gender representation in decision-making and research-performing processes 3. Maximise the impact and the efficacy of gender content into the research programmes The proposal aims at realizing and providing a double vision of equality (increasing the numbers of women in decision making positions throughout the R&I system will reduce the waste of European talents) and opportunity (providing support to the R&I entrerpreneurship based on more effective deployment female human capital, hence offering an important competitive advantage for strengthening the scientific endeavor). Dissemination and exploitation plans of the project results will then ensure the sustaianbility of the action after the ending of the H2020 project.

Keywords: gender content mainstreaming,gender balance in research institutions
Enhancers Decoding the Mechanisms Underlying CAD Risk (EnDeCAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Finland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 1498647.0
EU funding (EUR): 1498647.0
Participants: 1
Project status: SIGNED

In recent years, genome-wide association studies (GWAS) have discovered hundreds of single nucleotide polymorphisms (SNPs) which are significantly associated with coronary artery disease (CAD). However, the SNPs identified by GWAS explain typically only small portion of the trait heritability and vast majority of variants do not have known biological roles. This is explained by variants lying within noncoding regions such as in cell type specific enhancers and additionally ‘the lead SNP’ identified in GWAS may not be the ‘the causal SNP’ but only linked with a trait associated SNP. Therefore, a major priority for understanding disease mechanisms is to understand at the molecular level the function of each CAD loci. In this study we aim to bring the functional characterization of SNPs associated with CAD risk to date by focusing our search for causal SNPs to enhancers of disease relevant cell types, namely endothelial cells, macrophages and smooth muscle cells of the vessel wall, hepatocytes and adipocytes. By combination of massively parallel enhancer activity measurements, collection of novel eQTL data throughout cell types under disease relevant stimuli, identification of the target genes in physical interaction with the candidate enhancers and establishment of correlative relationships between enhancer activity and gene expression we hope to identify causal enhancer variants and link them with target genes to obtain a more complete picture of the gene regulatory events driving disease progression and the genetic basis of CAD. Linking these findings with our deep phenotypic data for cardiovascular risk factors, gene expression and metabolomics has the potential to improve risk prediction, biomarker identification and treatment selection in clinical practice. Ultimately, this research strives for fundamental discoveries and breakthrough that advance our knowledge of CAD and provides pioneering steps towards taking the growing array of GWAS for translatable results.

Keywords: enhancer,coronary artery disease,regulatory variants
3D bioprinting of pancreatic tissue for biomedical research (Pan3DP)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Israel,Switzerland,Belgium,France,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-10-01
End date: 2022-09-30
Duration (months): 48.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 6
Project status: CLOSED

Developing therapies for pancreatic diseases, such as diabetes and pancreatic cancer, is hampered by a limited access to pancreatic tissue in vivo. Engineering three-dimensional (3D) tissue models, which accurately mimic the native organ, have great potential in biomedical applications, by both providing powerful platforms for studying tissue development and homeostasis and for modeling diseases in pharmaceutical testing. Our research proposal establishes a multi-disciplinary European consortium with the ambitious goal of developing an innovative bioprinting approach for generating pancreatic tissue. Tissues and organs comprise multiple cell types with specific biological functions that must be recapitulated in the printed tissue. We will biomimic developmental processes to fabricate 3D bioprinted pancreatic tissue units that allow sustained cell viability, expansion and functional differentiation ex vivo. Specifically, the aim of this proposal is three-fold: 1. To expand and unify the knowledge of 3D in vivo architecture of the developing pancreas; 2. To develop bioprinting technology for engineering vascularized pancreatic tissue units; and 3. To establish conditions for in vitro differentiation and maturation of the bioprinted pancreatic tissue. This exploratory research in the emerging technological field of bioprinting will pave the way towards new technological possibilities of growing functional tissues and organs in a laboratory. We expect that the knowledge and paradigms generated by our research project will not only drive major technological advances in tissue-engineering and bioprinting, but will also open radically new possibilities in medicine, allowing to study pancreatic diseases ex vivo in fabricated tissue, to develop new drugs, and, possibly to facilitate the replacement of injured or diseased tissue.

Keywords: pancreas,bioprinting,3d cell printing,ex vivo disease model,ex vivo organogenesis,developmental biology
Enabling optimized disruptive airframe-propulsion integration concepts (ENODISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Belgium,Slovenia,Belgium,France,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Advancements in aerodynamics and innovative propulsion systems for quieter and greener aircrafts (H2020-MG-2019-TwoStages, 2019)
Start date: 2020-06-01
End date: 2024-11-30
Duration (months): 54.0
Total project cost (EUR): 5000000.0
EU funding (EUR): 5000000.0
Participants: 14
Project status: SIGNED

ENODISE is an enabler project aimed at reducing aircraft gaseous and noise emissions by improving the integration of the propulsion system with the airframe. Complex aerodynamic and acoustic engine-airframe interactions are involved, which must be better understood to yield the expected gains. ENODISE will investigate the main propulsion-airframe integration issues at low TRL and build a solid basis of knowledge and methods based on simplified but representative configurations, permitting to assess a variety of integration concepts. ENODISE will investigate the existence of local/global integration optima via an innovative experimental methodology combined with reduced order modelling and machine learning strategies. Selected configurations will be simulated using methods ranging from low-CPU to high-fidelity. The low-CPU techniques will be employed to verify if the experimentally observed optima can be obtained numerically, and the high-fidelity methods will contribute to the detailed investigation of the aeroacoustic mechanisms in addition to permitting a fine-tuning of the low-cost methods. The work being carried out on relatively low-cost generic configurations, this project will permit spanning a broad parameter space and testing optimization-based robust design methods. Finally, if the interactions between the flow and acoustic field of the propulsion system with the airframe can be detrimental to aerodynamic performance or noise, they also offer opportunities to explore novel flow and acoustic control strategies, not yet explored in combination with installation effects. ENODISE will implement advanced materials and shape modifications to mitigate the adverse installation effects observed during the first phase of the project. The last objective of this project is thus the inclusion of innovative flow and acoustic control technologies in the optimization loop in order to derive better integration designs with minimal detrimental installation effects.

Keywords: disruptive propulsion systems,boundary layer ingestion,distributed electric propulsion,propulsive efficiency
Millimeter Wave Massive Arrays enabling RFID/Radar Applications on 5G Smartphones (MAPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-20
End date: 2017-01-19
Duration (months): 18.0
Total project cost (EUR): 129807.0
EU funding (EUR): 129807.0
Participants: 1
Project status: CLOSED

Nowadays, a rising interest is moving towards the fifth generation (5G) of wireless mobile communication, as numerous devices and different heterogeneous networks will be interconnected, guaranteeing zero-distance connectivity between people, devices and objects. To deal with the ever increasing data traffic demand and the low power consumption requirements in the perspective of a sustainable growth, smart solutions have to provide energy- and cost-efficient services. In this context, the massive antenna arrays deployment in base stations, access points or smartphones, appears like a viable solution to meet these new challenges. Besides communication, the availability of such a technology can also allow other interesting applications such as accurate simultaneous localization and mapping (SLAM) performed by a personal radar integrated in smartphones, enabling new services in the device-to-device communication. In addition, the interrogation of tagged objects placed in the environment through radiofrequency identification (RFID) technology will allow a mapping of the real world into the internet space, enabling environment-related applications and constitute the so called smart space within the Internet of Things concept. Moreover, the reduced wavelength at millimeter-waves (mmW) paves the way for packing a large number of antenna elements into a small area, overcoming the difficult integration of laser-based or mechanical steering devices into mobiles. In this context, the project addresses in a unified framework the problem of achieving environment 3D mapping and objects identification by means of massive antenna arrays embedded on smartphones, which have the capability to learn from the environment and consequently continuously improving their performance. An offline-demo, exploiting real measured data performed during the project, will be realized in order to show the main achievements and performance guaranteed by the proposed system.

Keywords: massive arrays,smart radar,millimeter waves,backscattering rfid
Liver Spatial Omics (LSO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-11-01
End date: 2024-04-30
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The mammalian liver is a heterogeneous, yet highly structured organ, which performs diverse functions to maintain organismal homeostasis. Hepatocytes operate in repeating hexagonally shaped units termed lobules that are polarized by centripetal blood flow and morphogens. This polarized microenvironment facilitates optimal function by localizing specific processes to distinct lobule layers, a phenomenon known as ‘liver zonation’. While zonation of some key liver functions has been known for years, using spatially resolved single cell transcriptomics, we recently discovered that about 50% of liver genes are zonated. This surprisingly broad spatial heterogeneity raises a fundamental question - do hepatocytes form a uniform population that differs due to spatially graded inputs or are hepatocytes at different zones in fact distinct cell types? In this proposal we will tackle this question by developing techniques for sorting massive amounts of hepatocytes from defined tissue coordinates at high spatial resolution using zonated surface markers, new zonated reporter mouse models and mRNA content. We will perform a deep and comprehensive profiling of the hepatocyte genome, methylome, epigenome, transcriptome, proteome and metabolome at each zone to characterize liver zonation at all relevant cellular scales. We will also develop an ex-vivo system to functionally characterize the response of hepatocytes from distinct zones to identical input stimuli and the ability of hepatocytes to inter-convert to hepatocytes with differing zonal identities. These experiments will be performed in different metabolic states and along a high fat diet. This project will uncover new features of liver zonation in health and disease and redefine the hepatocyte cell state. Our approach for spatially refined tissue omics can be extended to other structured mammalian organs, thus opening new avenues of research in Systems Biology of mammalian tissues.

Keywords: design principles,mammalian systems,liver zonation,single molecule transcript imaging
Electrochemical Sulfonylation of Lysine Residues in Continuous Flow Microreactors. (ELECTROSULF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-05
End date: 2021-09-04
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Peptides are important molecules, ubiquitous in biological systems. Their relevance in the pharmaceutical sector is proven by the constant increase which the global market of peptide-based drugs is experiencing in the last years. As a consequence, several methods have been developed to modify peptides (e.g. condensation, cross-coupling, transition-metal catalysis, and photocatalysis), being lysine with its free amine one of the most preferred handles used by chemists to introduce a new moieties, e.g. cytotoxic drugs or fluorescent labels. Several transformations as alkylation, arylation, oxidation, acylation and condensation have been described for lysine. However, it would be very appealing to introduce selectively a sulfonyl group, which would result in the formation of a sulfonamide, a functionality which is widely employed in drugs. Although several oxidative sulfonylations are reported in the literature, their drawbacks motivate me to look for greener synthetic strategies. Electrosynthesis represents an advantageous alternative, which has been re-discovered in the last years also thanks to its employment in continuous-flow microreactors. With the support of this modern technology, it is possible to minimize the difficulties connected to older electrochemical processes (such as mass-transfer limitation, the need of a supporting electrolyte,and the difficult scale-up). ELECTROSULF aims at developing a novel sulfonylation of lysine by electrochemical means with the use of a flow microreactor. The reaction mechanism will be also properly studied. My strong background in organic chemistry together with Prof. Timothy Noël’s expertise in flow processes and reaction miniaturization will guarantee the success of ELECTROSULF, whose achievement will have a great impact on the pharmaceutical sector, paving the path to a new approach for peptide modification.

Keywords: electrochemical sulfonylation,flow processes
TRAIN-HEART (TRAIN-HEART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Germany,Germany,Italy,Belgium,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-06-01
End date: 2023-08-31
Duration (months): 51.0
Total project cost (EUR): 3940388.64
EU funding (EUR): 3940388.64
Participants: 16
Project status: SIGNED

TRAIN-HEART brings together leading academic teams and (biotech) companies to train the next-generation of innovation-minded researchers who can expand the scientific horizons and accelerate future development of RNA-based therapeutics for the treatment of ischemic heart failure. Under chronic cardiac stress, non-coding RNAs, in particular microRNAs and long non-coding RNAs, act as critical regulators of cardiac tissue remodelling. Innovative therapies targeting these RNA molecules hold great promise in treating the underlying causes of ischemic heart failure. With the exception of heart transplantation, there is no curative therapy available for this detrimental disease. Given the challenges related to delivery, specificity and tolerability of RNA therapeutics, developments in chemically modified oligonucleotides and drug delivery strategies are growing substantially. TRAIN-HEART’s proposition is to train a league of 15 promising fellows that harness novel insights in the pathogenesis of ischemic heart failure, study the therapeutic potential of existing RNA therapeutics and improve its efficacy by the design of novel drug delivery systems. TRAIN-HEART provides such training in a European network of top-level academic teams and (biotech) companies active in the fields of cardiovascular biology, functional genomics and drug development. All individual research projects demonstrate multidisciplinary content and supervision arrangements, momentous intersectoral exchanges and international synergies. These PhD programmes are complemented with the right combination of specialised research- and transferable skills trainings to encourage excellent science, innovation and long-term employability. The TRAIN-HEART fellows are envisioned to become entrepreneurial researchers who are keen to bring cutting-edge scientific concepts in RNA therapeutics to the clinic.

Keywords: microrna,lncrna,ischemic heart failure,antisense oligonucleotides,nanomedicine
Transformation and the management of HIStorical foresT. Landscapes of the Eugaean Hill (Padua, Italy). Fresh perspectives through spatial analyses and dendro-anthracology (THISTLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

To better anticipate global changes (environmental, climate and social changes), research over the past twenty years has focused on understanding and measuring the interactions between societies and their environment. Knowledge of past environments and their evolution in relation to society can help contribute to better manage, protect and anticipate present and future environments. This project adds to this dynamic research with a focus on forests. Forested landscapes represent the ecological inheritance of centuries of forest management to supply, among other products, the fuel necessary for human activities. Thus, to meet their demands for firewood past societies gradually modified and transformed the landscapes they inhabited. We focus here on the evolution of historical forests in the Euganean Hills (Colli Euganei, Padua-Italy) through wood charcoal production. Charcoal production is extremely polymorphic and fully understanding it requires the use of different approaches and disciplines (including history, ethnography, archaeology, geography, archaeobotany etc.) The aim of this project is to develop an integrated approach combining all disciplines to reconstruct forest landscapes on the Euganean Hills at different temporal and spatial scales. The choice of the Euganean Hills has been guided by its interesting biodiversity, by the numerous diachronic archaeological surveys previously undertaken, by the wealth of written and cartographic documentation concerning the uncultivated lands and also by the willingness of local actors to promote their region thanks to the richness of the landscape and its history. The project THISTLE aims to reconstitue the history of cultural landscapes, and more precisely of forest landscape of the Euganean Hills (Colli Euganei, Padua-Italie) with a pluridisciplinary approch in order to protect and promote them at different geographical scales (from local to global)

Keywords: archaeological landscapes,cultural heritage,forest history,charcoal production,anthracology,historical mapping