Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ehcoBUTLER. A global ecosystem for the independent and healty living of elder people with mild cognitive impairments. (ehcoBUTLER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Innovation actions
Countries involved: Italy,Spain,Spain,Israel,Spain,Italy,Spain,Greece,Serbia,Slovenia,France,Netherlands
Call: Advancing active and healthy ageing with ICT: ICT solutions for independent living with cognitive impairment (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-01-01
End date: 2022-03-31
Duration (months): 87.0
Total project cost (EUR): 3642068.27
EU funding (EUR): 2980347.0
Participants: 18
Project status: CLOSED

The ehcoBUTLER Idea: Nowadays, it is a fact that Europe is ageing. A common characteristic of elders is the frequent occurrence of either physical or mild cognitive impairments. This situation brings new challenges in how to improve the independence and quality of life of elderly people and promote their good health in different ways. The ehcoBUTLER project addresses this challenge by developing an ICT technological platform with both leisure and care apps. The main objective of ehcoBUTLER is to demonstrate the socio-economic benefits from the deployment of several innovative and user led ICT pilot projects based on different business models in order to be able to translate promising results into scalable practice across Europe. How the objectives will be achieved: The ehcoBUTLER Consortium is composed by a multidisciplinary combination of specialist partners on their areas and responsibilities, in order to satisfy the requirements emerging from the EU Call and the particular PHC-20 topic. With this consortium we expect to contribute to break the technological barrier that exists nowadays between the elderly and the ICTs, encouraging the e-Inclusion, to facilitate psychological and cognitive techniques and support procedures, both for the elderly people and for the informal and formal caregivers, to develop an interoperable and open ICT platform particularly designed and adapted to elderly people, to demonstrate the ROI from several four business models based on the deployment of this ICT platform and to generate an ecosystem for apps provider that will allow end users to integrate all the leisure and care related activities in just one platform. To ensure that the platform can be scaled to an operational deployment in the European Market we will deploy ehcoBUTLER in 5 countries and 7 pilot sites to reach the higher number of users and to test the suitability of ehcoBUTLER in different but related business cases.

Keywords: bridge digital gap for elder people with mci,daily living activities,social inclusion and participation,cognitive and physical training,open ict ecosystem for apps providers,health monitoring
Identity Management on Social Media by Diasporic LGBTQs (FACELOOK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2019-05-02
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The internet, and social media in particular, create new opportunities and pose new challenges for the ways people think about themselves as well as manage the expressions of their identities. In this research project I aim to enrich our knowledge about the transformations of identity in the new media landscape of the early XXI century by investigating those transformations from the perspective of diasporic LGBTQs, that is, lesbian, gay, bisexual, transgender and queer people. I will focus on the latest theories on social media and identity about 1) fixating the fragmented self (van Zoonen 2013), 2) collapsed contexts (boyd 2011) and 3) the multiplication of contexts (Papacharissi 2011), by investigating those phenomena from the perspective of Polish post-accession immigrants to the UK. I will examine what diasporic LGBTQs and their social media’s uses can teach us about the relationship between the internet and identity, as well as what opportunities and difficulties social media create to a group that faces different challenges of exclusion and discrimination. I will first use a quantitative survey to map the diversity of social media used by Polish LGBTQs in the UK. However, because I am primarily interested in meanings of daily media practices, it is qualitative methods, and in-depth interviews in particular, which will form the core of my methodological toolkit. At the same time, to trigger more and better quality data I will combine traditional qualitative methods with such innovative approaches as think-aloud protocols (which require from participants to talk about the activity in which they are involved) and digital methods (the methods of the medium under scrutiny).

Keywords: social media,facebook,identity,migration,sexuality,lgbtq,poland,united kingdom
Chiral semiconductor nanophotonics for ultraresolved molecular sensing (CHANSON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Belgium,Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499858.0
EU funding (EUR): 1339812.5
Participants: 2
Project status: SIGNED

Chirality plays a pivotal role in chemistry and medicine because most biological molecules have either right- or left-handed conformations. Circular dichroism can distinguish the chirality of matter thanks to a small difference in absorption of light with opposite circular polarizations. However, it is severely limited by low sensitivity and low spatial resolution due to weak chiral light-matter interaction. As a result, using light, we cannot resolve the chirality of individual nanoscale objects for critical applications such as detecting protein aggregates responsible for a variety of diseases. CHANSON pushes the limits of optically resolvable chirality through new concepts in semiconductor nanophotonics. We tailor semiconductor nanostructures to specifically boost chiral fluorescence thanks to the interplay of photons, charges, and spins. Using novel contrast mechanisms, we increase both fluorescence intensity and polarization to remove the barriers that hinder circular dichroism. The project combines two routes for ultrasensitive and super-resolved molecular detection: 1) Nanophotonic sensors based on semiconductor nanoantennas; 2) Excitonic sensors based on atomically thin semiconductors. The ambitious target is to map with nanoscale spatial resolution the lowest possible molecular concentrations down to a single chiral molecule. To tackle this major scientific challenge, I propose the concept of a metasurface canvas consisting of arrays of semiconductor nanostructures. By providing a platform for fluorescence-based sensing of both light-emitting and non-emitting analytes, the results could revolutionize the screening of pharmaceuticals for neurodegenerative diseases, amongst others.

Keywords: nanophotonics,optical chirality,circular dichroism,fluorescence,two dimensional semiconductors,high index dielectric nanoantennas
Advanced Wide-Band Transceiver Architectures for Beyond 5G Wireless Systems (ADVANTAG5)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 267793.2
EU funding (EUR): 267793.2
Participants: 2
Project status: CLOSED

The fifth generation and beyond radio systems targets 1000 times traffic volumes compared to present state-of-the-art. In order to guarantee the quality of service, communication capacity leap of three orders of magnitude requires sophisticated interference management and communication channel protection from the interference generated by other users. The objective of this project is to develop integrated transceiver hardware structures for massive MIMO/beam forming antenna arrays, supporting agile carrier aggregation, digitally assisted interference management, and full duplex communication, thus enhancing communication efficiency in spatial, temporal and frequency domains. The evolution of communications systems inherently relies on integrated microelectronic circuits. In circuits developed in this project, we will fully exploit the digital-driven process evolution by utilizing digitally intensive time/phase domain signal processing as much as possible to minimize the effect of existing discrepancy between digital-driven process scaling and analog circuit design. The developed structures will take advantage of time/phase domain signal processing, taking full advantage of CMOS process evolution and inherently supporting beam forming antenna array structures. We will demonstrate the effectiveness of design methods by implementing transceiver hardware structures for massive transceiver arrays. Digitally reconfigurable transceiver arrays will enable spatial multiplexing, agile carrier aggregation and digitally assisted interference management to enhance communication efficiency in spatial, temporal and frequency domains, enabling the targeted capacity leap.

Keywords: integrated circuit,transmitter,receiver,interference,fifth generation communication systems,mimo,antenna array,beam steering,time based signal processing,outphasing
Anticipatory design and ethical framework for Distributed Ledger Technologies (blockchain or DAG) and applications (smart contracts, IoTs and supply chain) (AnticipatoryLedgers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The proposed research analyzes the current “blockchain paradox,” also described as a “governance crisis” in the emerging DLTs (Distributed Ledger Technologies), as a challenge of connecting prototyping practices with policy analysis and ethical deliberation, which is also an important goal for the STS (Science, Technology and Society studies) scholarship reflecting emerging technologies. The research will contribute to the fields of Design methods, STS scholarship and DLTs development by offering a method for involving stakeholders in the DLT design, which combines prototyping, reflection and stakeholder panels. In this attempt to integrate technology, ethics and governance we plan to identify and categorize the assumptions behind various coins and DLTs’ protocols and reflect upon their connections to current social and political realities. The objective is to create, test and evaluate an experimental framework described as “anticipatory design” of DLTs applications, which involves the public and various stakeholders directly in the design process rather than only the adoption and implementation of “smart contracts”. This experimental, design and policy driven research will and focus on private health/body data, but also sensor data related to the environment as “oracles” and “escrows” in the smart contracts over Ethereum and IOTA platforms. With anticipatory design of “smart contracts” we will evaluate the neglected issues of DLTs governance (accountability, shared responsibility, division of powers or solidarity), but also ethical principles (deontological versus utilitarian rules and laws) and future scenarios and use cases (smart contracts with AI, smart contracts for wearables or IoTs with a focus on environmental sensors).

Keywords: blockchain,distributed ledger technologies,design methods,anticipatory governance
Digital Protein Biophysics of Aggregation (DiProPhys)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1999715.0
EU funding (EUR): 1999715.0
Participants: 1
Project status: SIGNED

Proteins are the fundamental building blocks of life, underpinning functional processes in living systems. They are able to exert their biological activities by binding to other proteins to form functional complexes which act as the machinery of life. In certain cases, however, proteins escape cellular quality control mechanisms and form aberrant complexes. The formation of such clusters stabilised by inter-molecular hydrogen bonds, amyloid aggregates, has dramatic consequences for biological systems and they are implicated in neurodegenerative disorders. The fundamental biophysical chemistry governing the formation of protein clusters has been challenging to probe and understand as this process results in a highly heterogeneous distribution of aggregates of different sizes and with different properties, and correspondingly diverse effects on living cells’ function. As such, conventional bulk methods are challenging to apply to uncover a fundamental biophysical understanding of their formation, dynamics and behaviour. The present proposal addresses this fundamental problem by bringing together microfluidics and single molecule spectroscopy to develop a novel digital biophysics platform for studying protein aggregation. Through this route, we will be able to study aggregates one by one, inside and outside cells, and discover the fundamental physical determinants that govern their formation and effects on the cellular systems. This proposal is motivated by the hypothesis that the physico-chemical properties of protein aggregates modulate their biological activity, and by studying protein aggregation at the level of single aggregates and single cells, we will access fundamentally new biophysical chemistry, including how liquid-liquid phase separation can modulate the nucleation barriers in protein aggregation, what the molecular mechanisms are by which amyloid aggregates can self-multiply, and what physical parameters determine their effects on living cells.

Keywords: protein aggregation,liquid liquid phase separation,protein biophysics,digital biology
Unraveling effects of anisotropy from low collisionality in the intracluster medium (LowCollICM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-12-30
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Despite advances in both instrumental and computational capabilities, there still exists a mismatch between the observations of and theory describing galaxy clusters – the most massive gravitationally bound objects in the Universe. Galaxy clusters are used as probes for cosmological models and thus are important to our fundamental understanding of the Universe. Some differences clearly originate from an incorrect treatment of microphysical processes in large-scale cosmological simulations. This applies, in particular, to the intracluster medium (ICM). Particle collisions are rare in this hot, diffuse, magnetized plasma. In simulations the ICM is typically treated as a fully collisional fluid with an isotropic pressure. Hence, small-scale physics that stem, for example, from an anisotropic pressure, are missing. With this action the researcher will pave the way for the development of a model that allows for the incorporation of these small-scale effects into large-scale cosmological simulations. To achieve this, the researcher will implement anisotropic viscosity and thermal conduction in a next-generation, exascale simulation code. This code will then be used to conduct and analyze simulations of different aspects of the ICM covering both idealized, turbulent subvolumes and global isolated galaxy clusters. In doing so, the researcher will determine which effects are dynamically important, how they affect observables such as Faraday rotation measures and surface brightness discontinuities, and how to model them. Ultimately, future cosmological simulations employing a more accurate model will facilitate a more fundamental understanding of the magnetized Universe.

Keywords: turbulence
Development of lipid nanoparticles based on solid matrix for Benznidazole oral delivery targeting to the lymphatic system to treat Chagas disease (LYMPHVECs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

According to the WHO there are 8 million persons chronically infected by Chagas disease (CD) resulting in 12.000 reported deaths annually. CD is one of the most significant health problems of Latin America. However, nowadays it has been reported worldwide. Benznidazole (BZ) has been recently approved in US (30/08/2017) as the first option treatment for CD but can only administered for 14 days or less, while it is known that at least 2-3 months of treatment are required for full efficacy. This approval for short-term CD therapy is due to the severe side effects associated with extended use, which severely impacts the applicability of BZ as a universal CD treatment. Importantly, Trypanosoma cruzi (Tc) parasite reservoirs have been localized into the Lymphatic System (LS). Poor compound distribution into the LS could be the reason why extended BZ treatment is required and why reactivation of the parasites in the chronic stage is commonly found. Chagas infected people treated with BZ develop rashes, fever, nausea, headache, allergic dermatitis, digestive intolerance (anorexia), peripheral neuropathy and insomnia. These severe side effects limit its use and foster non-compliance. BZ formulations that reduce compound exposure in system circulation while facilitating distribution into the LS could reduce the efficacious dose (at present 5-7mg/kg/day), reduce side effects, and possibly contribute treatment shortening. This project will develop BZ formulations based on solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) to achieve these three goals.

Keywords: chagas disease,trypanosoma cruzi,benznidazole,drug delivery,nanoparticles
Optoelectronics with Complex van der Waals Heterostructures (OPTOvanderWAALS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

Two-dimensional (2D) materials have attracted the attention of the scientific community since the discovery of graphene in 2004 (an atomically thin layer of graphite), due to the new and interesting physical phenomena found in this material. Graphene was not just a scientific breakthrough from a physical point of view, but it also opened the door to research on atomically thin materials. Nowadays, many materials with a wide range of properties (metals, semiconductors, insulators, superconductors…) have been achieved in a 2D configuration, and still there are more to come. The proposed project OPTOvanderWAALS aims to the fabrication and study of complex van der Waals heterostructures to study inter-layer excitonic phenomena and use these excitonic effects to fabricate ultra-high-performance optoelectronic devices. Novel intermediate layers between 2D semiconductors will be employed to automatically switch on and off photodetectors with an extraordinarily low dark current, which will be translated in an ultra-high-performance. These intermediate layers will be also used in photovoltaic cells as recombination region, allowing the recombination of unbalanced electron-hole pairs and avoiding charge build-up in the cells, resulting in an increased open-circuit voltage and, therefore, higher efficiency than state-of-the-art 2D photovoltaic cells. Besides, all of these heterostructures will be fabricated following a new procedure to align the crystal structure of different layers by second harmonic generation imaging, resulting in an optimized interaction between layers that will ultimately lead to ultra-high-performance devices in a new generation of flexible and transparent optoelectronics.

Keywords: van der waals heterostructures,2d materials,photodetector,solar cell,semiconductors,nanotechnology