Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of an innovative Airway-on-Chip microbiome cell culture model to investigate host-microbiome interactions at the airway epithelial surface (EpiCBiome)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 162864.6
EU funding (EUR): 162864.6
Participants: 2
Project status: CLOSED

Patients with chronic inflammatory lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence of respiratory infections. These infections accelerate disease progression and are associated with substantial morbidity and (especially in COPD) even mortality. Recent studies show that the airway microbiome of patients with asthma and COPD is different from that of healthy subjects. In murine lungs this has been shown to promote airway inflammation and loss of lung function. To this point it is unclear how changes in microbiome composition contribute to susceptibility for respiratory infections. Currently, treatment of patients with asthma and COPD is limited to symptom reduction and prevention of disease progression and hampered by the large amount of patients resistant to corticosteroid treatment. Understanding why these patients have an altered microbiome and increased susceptibility to respiratory infections is therefore pivotal to develop more effective healthcare strategies. Studies on host-microbiome interactions are mostly performed in murine models of airway diseases. Unfortunately, these models often fail to accurately reflect human disease. However, the recent development of Organ-on-a-Chip technology has effectively recapitulated many features of the modelled organ, thereby adding a level of complexity to cell cultures that is urgently needed. In contrast to existing airway epithelial cell cultures, these models contain several cell types, cultured at the air-liquid interface under a constant flow of air and nutrients while exposed to mechanical stress. However, also these cultures still lack an essential component of the airways: the airway microbiome. Therefore, the work described in this proposal aims to create an innovative human state-of-the-art Airway-on-Chip microbiome model to investigate the interaction of the airway epithelium with the microbiome and how this is linked to susceptibility for infection.

Keywords: microbiome,organ on a chip,airway epithelium,asthma,copd,infection
A digital based system for measuring, showing and regulation of the complexe system of wine feremtation with high precision via a Bluetooth -Refractometer, a Software and a Bluetooth Thermostat (VINOQUANT11SUPERPLUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: SIGNED

The main market for our product is the wine making process. During the wine fermentation, the most critical point is a stop during the fermentation. The fermentation process is a fragile balance between yeast, which will transform sugar into alcohol and CO2. During the fermentation, the most common method of managing the process is by raising or decreasing the temperature in the tank. Another method is by pressure, but this is highly expensive and not so accurate, as it prevents the yeast to grow and work. Our system consists in - Software - Bluetooth digital refractometer - Bluetooth digital Thermostat - Derivation Box By measuring the liquid with the Refractometer, the value will be automatically sent to the software. At the moment of the reception of the value from the refractometer, the software connects via Bluetooth with the Thermostat to request the actual temperature of the connected tank. Then the actual values will be treated and shown in a graph directly after a confirmation of the values by pressing ”OK” Button which will appear at that time. Then the software calculates the difference between the actual point of evolution in the tank and the optimal situation. For creating an optimal curve, the winemakers have to enter some specific values in the system once he creates the tank. After the calculation, the software automatically sends the optimal fermentation temperature back to the thermostat. As the thermostat is linked vie the derivation box to the cooling/heating circuits of the specific tanks, the thermostat and derivation boxes works accordingly to change the temperature to the desired temperature in the tank till the next measurement will be done.

Keywords: fermentation,wine,must,digital,bluetooth,refractometer,thermostat,algorithm,alcohol,rest sugar,temperature guiding
Assay-Ready Organ Network (ARON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In drug development, there is an urgent need for more physiological and predictive pre-clinical in-vitro assays to test the efficacy and toxicity of compounds. This to allow new medicines to be brought to the market quicker and safer. With the growing biological complexity of today’s diseases, it is vital to have interconnected 3D tissue structures of multiple organs in order to investigate biological cross-talk. Today, such physiological and predictive pre-clinical in-vitro assays are not available. Here, InSphero presents ARON, their Assay-Ready Organ Network, to address the urgent need for more physiological and predictive pre-clinical in-vitro assays and aims to study the feasibility of a successful market introduction. ARON is the most advanced modular in-vitro assay platform and will set a new standard for a wide range of cell-based pre-clinical testing by shifting the organ-on-a-chip technology from a late-stage, luxury service to routinely used ready-to-use assays. This enables pharma and biotech companies to develop drugs in a faster and more efficient way, without the use of animals. All elements and process steps guarantee routine implementation for everyone, while experimental complexity is minimized. ARON has the unique option that the consumables are assay-ready, directly shipped on-site, on-demand, and worldwide. InSphero is a leading supplier of organotypic in-vitro 3D microtissues for predictive drug testing and has grown yearly by 40% in the past years. ARON will turn today's service possibilities into a scalable product and will enable to offer assays for highly competitive pricing. The (USA dominated) 3D tissue market is expected to grow with CAGR of 63% to reach a market size of 1.5 billion EUR in 2024. A successful market introduction will impact the EU’s society and economy by creating hundreds of jobs, accelerating drug development that will improve the health of EU-citizens, while reducing cost, time-to-market and the need for animal testing

Keywords: drug testing,safety,efficacy,multi organ,micro physiological system,disease modelling,inflammation
Validation of Integrated Safety-enhanced Intelligent flight cONtrol (VISION)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Hungary,France,France,United Kingdom,United Kingdom
Call: International cooperation in aeronautics with Japan (H2020-MG-2015_SingleStage-A, 2015)
Start date: 2016-03-01
End date: 2019-08-31
Duration (months): 42.0
Total project cost (EUR): 1796877.5
EU funding (EUR): 1796877.5
Participants: 6
Project status: CLOSED

To enhance air transport safety, the main objective of VISION is to validate smarter technologies for aircraft Guidance, Navigation and Control (GN&C) by including 1/ vision-based systems 2/ advanced detection and resilient methods. Critical flight situations are targeted, especially during near-ground operation phases (half of 169 fatal accidents in the last decade during approach or landing). Actually, despite continuous improvements in reliability and performance, the complexity of Flight Control Systems also requires to use many sources likely to suffer from faults and environmental conditions. To overcome these anomalies, recent projects have evaluated advanced solutions, but their transfer to the industry is slowed down by lack of flight validations, limitations of on-board computers or certification issues. The TRL reached by both sides are rather equivalent, with dissimilar pros and cons. Accordingly, VISION aims at capitalizing on the know-how and experience independently acquired to make a significant improvement and maturation of the TRL achieved. To demonstrate the solutions, complementary efforts will be undertaken and two scenarios are considered: i) Flight control recovery, ii) Navigation and guidance recovery during the final approach phase. In i), Fault Detection and Diagnosis and Fault Tolerant Control techniques will be implemented in faulty situations. In ii), vision will be used to estimate and modify the aircraft glide path when local navigation data is denied, or when unexpected obstacles are detected. In both cases, the GN&C systems will be tested on real aircraft platforms and their performance evaluated. VISION will result in flight-validated GN&C solutions with increased TRL, with benefits for the European aircraft industry.
Legitimacy, Financialization, and Varieties of Capitalism: Understanding Sovereign Wealth Funds in Europe (SWFsEUROPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-01-31
Duration (months): 61.0
Total project cost (EUR): 1414722.0
EU funding (EUR): 1414722.0
Participants: 2
Project status: SIGNED

The number and size of sovereign wealth funds (SWF) has grown substantially in the last decade, leading to an unsettled debate regarding their legitimacy in the global political economy. Some suggest they represent the (re)emergence of state-led capitalism subject to geopolitical motivations that threaten free markets. For others, SWFs represent a source of long-term patient capital capable of mitigating market short-termism. Either way, SWFs challenge the norm, particularly in the West, that financial markets are spaces of exchange for non-state actors. In three complementary and interdisciplinary work programmes the SWFsEUROPE project will explain the evolving and variegated pattern of ‘sovereign fund capitalism’ in Europe, developing a new theory of the relationship between states and global finance. First, the project breaks new ground by explaining and theorizing how the legitimacy of SWFs as commercially oriented investors is performed when they are still entities of the state. No study has critically examined how legitimacy is performed via mechanisms such as the International Forum of Sovereign Wealth Funds and the Santiago Principles, or the growing evidence of collaboration with cognate institutional investors (e.g. pension funds). Second, this projects seeks a multi-layered explanation of the uneven pattern of investment flows and stocks of foreign SWFs into European countries through hypothesis testing of aggregate investment data with different theories of national-institutional variety, coupled with a comparative analysis of the bilateral investment-promotion relationships of investment-receiving countries. Third, the project will compare the growth and development of European SWFs. There is no comparative study exploring why some states are sponsors of an SWF (e.g. Italy, France, Ireland) and others are not (e.g. UK), what the motivations are and how they are made legitimate.
Innovative Stamping Die for Aluminium Ribs Hot Stamping (Rib-ON)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain
Call: Development and manufacturing of innovative stamping dies for aluminium ribs Hot Stamping (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2018-01-01
End date: 2021-06-30
Duration (months): 42.0
Total project cost (EUR): 474050.0
EU funding (EUR): 353347.5
Participants: 3
Project status: CLOSED

The overall aim of the “Rib-On” project is to develop and manufacture an innovative stamping die based on a modular/reconfigurable and low cost approach to successfully produce different outer external wing rib models using new high performance aluminium alloys and tailored die steel and coating solutions. The die will serve to manufacture different shape/length aluminium ribs. The following challenges must be overcome for the success of the project: -Hot forming of aluminium is not a widespread technology -Die users allow little play to improvement by material selection. -Modular/reconfigurable dies are infrequent. -Integrating heat treatment and stamping in a single operation allows reducing costs but is difficult to achieve. These five points lead to the most remarkable fields of expertise that gather at Rib-ON project. The consortium has wide experience in relation to the expected impacts. BATZ is a stamping die manufacturer for automotive and engine part manufacturer for aerospace industries and IK4-AZTERLAN / F.AZTERLAN has an extensive experience of more than 30 years in metallurgy. As for the operative approach, Rib-ON proposes to face the development of the new aluminium wing rib hot stamping die in the following sequence: 1.Functional requirements of the die will be set at first (WP1). 2.Once the die requirements are set, its concept design will be developed (WP2): 2.1.Processing window of the aluminium sheet must be defined. 2.2.Selection of the most advantageous die steel and coating will be performed. 2.3.Shapes of the blank and the forming surface of the die will be designed for each wing rib by simulation. Die cooling channel design will be simultaneous. 2.4.Modular die concept will be developed and prepared for subsequent detailed design. 3.Detailed design of the die and the corresponding manufacturing plan will be carried out (WP3&4) 4.The die will be set at BATZ's facilities for validation (WP5)

Keywords: hot stamping,modular and reconfigurable die design,aluminium stamping,hot forming,aerospace,wing,scandium
The Human Face of AI (Furhat)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 3228000.0
EU funding (EUR): 2259600.0
Participants: 1
Project status: CLOSED

Interacting with AI by talking is becoming increasingly common. Today we can order food, find out currency exchange rates & get answers to FAQs by messaging bots running in Facebook, WhatsApp or Telegram. Virtual assistants like Apple Siri, Amazon Alexa or Yandex Alisa migrate from smartphones to smart speakers in our living rooms. Simultaneously we are witnessing the emergence of social robots—a new class of robots for whom social interaction plays the key role. A social robot is a robot that can show emotions, have capabilities to converse on an advanced level, understands the mental models of its social partners, forms social relationships, makes use of natural communication cues, shows personality & learns social capabilities . In essence, a social robot = robot or AI + social interface. There are serious technological problems to broad acceptance of social robots & the main one is the non-realistic interactions. At Furhat Robotics we are developing the 1st scalable social robotics platform. Furhat, the robot built on this platform, is a fully programmable social robot capable of expressing a broad range of emotions & carrying out a realistic conversation with humans. We have sold 80+ Furhats to 50+ customers—Disney, Intel, Merck, KPMG, Swedbank, Deutsche Telekom, Honda & others. Finally, we are an official partner of the Dubai Expo2020 exhibition. In total we have generated €2.1m in early revenues. In Sep 2017 we raised €2.13m of venture capital from Balderton Capital & LocalGlobe (both from the UK). We are aiming at creating completely new markets for social robotics solutions. We are aiming at commercialising ~10,000+ Furhat robots by 2023, generating €30m in annual revenues. Long-term, we believe we can become the next Swedish & European unicorn company, exceeding the €1bn valuation.

Keywords: social robot,conversational interface
The first DRY Electropolishing technology for high-precision components (DLyte PRO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-02-01
End date: 2021-06-30
Duration (months): 29.0
Total project cost (EUR): 2370508.75
EU funding (EUR): 1659356.13
Participants: 1
Project status: CLOSED

People may wonder why experts pay so many attentions to the part’s surface but not the bulk part itself. The answer is obvious since most of the manufacturing-machined parts fail starting from just the surface and finally result in malfunction in practice. Specifically within metal industry, the surface roughness of a workpiece strongly influences its properties and functional performance, including abrasion/corrosion resistance, dirt adhesion, as well as the visual impression for clients. There are crucial applications where surface properties and final tolerances prove to be CRITICAL for the intended function of the products (body implants, dental frames, aeronautics, etc..), therefore several metal-based industries need to accurately grind and polish specific pieces as part of the manufacturing process. Unfortunately, nowadays, state-of-the-art solutions for high-precision metal polishing are intensive time-consuming and/or render sub-optimal results. At Steros GPA Innovative S.L, after 3 years of technical development, we are presenting DLyte: a patented technology that will overcome current drawbacks and represent a real breakthrough for high-precision surface finishing. DLyte assures significant operational savings in time and costs and reduced hazardous impacts on the worker and the environment. Concerning performance, surface quality will be improved in terms of productivity, accuracy and higher flexibility regarding item’s geometries. The first DRY Electropolishing technology for high-precision components. We have validated DLyte by means minimum viable product pre-series sold and an attractive business plan, which estimates yearly revenues for GPA Innova up to 39.7Million€ and cumulated benefits reaching 15.6Million€ by the end of 2024. However, despite the great effort done up to this point, the equipment still needs to solve specific limitations related with technical and business-oriented requirements before obtaining a marketable certified unit.

Keywords: surface finishing,polishing,additive manufacturing post processing,metal industry,medical implants surface finishing,electro chemistry
Prototyping Internet Lot of Things Software (PILOTS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Virtual platforms have been mainly used to support anticipation of embedded software (eSW) development of very complex System on Chip (SoC) or for Software-based functional validation of complex IP. The explosion of the number of connected things change the complexity paradigm: the challenge is now to manage hundreds of distributed platforms (SoCs or boards) that include processors, sensors, MEMs and communication devices. Using physical board to prototype each of these platforms to verify the overall system behaviour is too expensive and not scalable for system providers. System integrators require a scalable solution for system prototyping. The use of virtual platforms appears to be the answer, but they lack tools to deploy and integrate this solution in their prototyping flow. According to state of the art and technical analysis with CEA and Fraunhofer, no such solution is available today; as a long time provider of hardware integration platform, Magillem has been a pioneer in design environment software for SoC integration and SoC virtual platform since its early days and believe to be in a unique position to introduce a very innovative solution for IoT enablement. By using PILoTS, European leading system integrators, as well as suppliers of MEMS, micro-controllers, connected systems would save time and cost, during design, verification and certification, and vastly improve their competitiveness.

Keywords: internet of things