Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamic Interplay between Energy and Memory (EnergyMemo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2023-03-31
Duration (months): 66.0
Total project cost (EUR): 2499500.0
EU funding (EUR): 2499500.0
Participants: 1
Project status: SIGNED

Understanding the links between neuronal plasticity which underlies memory and energy metabolism is a major goal of brain studies. The brain is a main energy consumer and the central regulator of energy homeostasis, and it prioritizes its own supply over peripheral organs. Interestingly, our work demonstrates that the brain is also able to regulate its own activity under energy shortage to favor survival. The EnergyMemo project proposes to perform in drosophila an original integrated study of the interplay between energy metabolism and olfactory memory at the molecular, cellular and circuit levels. On the ground of important preliminary results, we will investigate in vivo how and why the energy flux increases during long-term memory encoding, and how brain plasticity is regulated by the energy supply. We will focus on three major challenges: * Objective 1: to improve our understanding of brain physiology, we will characterize in drosophila neuronal circuits that integrate information about the brain energy status. * Objective 2: to understand how abnormal levels of energy can affect the brain, we will analyze how the energy level shapes the functioning of the olfactory memory center. * Objective 3: to characterize how energy stores are mobilized during memory formation, we will investigate how the neuronal and glial networks interact to manage the energy fluxes. This multidisciplinary project will benefit from our team's longstanding experience in behavioral studies and leadership in live brain imaging, in addition to the unmatched descriptive power of drosophila neuronal circuits at the single-neuron resolution. Successful completion of this program will surely uncover mechanisms of brain function conserved across species, and should bring-up new ideas about how deregulation of energy metabolism can affect cognitive functions in human. Thus the EnergyMemo project could have a major impact in neuroscience from fundamental research to human applications.

Keywords: olfactory learning,long term memory,drosophila,energy metabolism,neural circuits,neurophysiology,in vivo brain imaging,glia,rna interference
ADvancing user acceptance of general purpose hybridized Vehicles by Improved Cost and Efficiency (ADVICE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Austria,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Italy,Sweden,France,France,Czechia,United Kingdom,United Kingdom
Call: System and cost optimised hybridisation of road vehicles (H2020-GV-2016-INEA, 2016)
Start date: 2017-04-01
End date: 2020-09-30
Duration (months): 42.0
Total project cost (EUR): 11717524.04
EU funding (EUR): 9359907.969999999
Participants: 25
Project status: CLOSED

ADVICE aims at increasing the number of HEVs up to 10% of all vehicles registered in the mid-term range. This will be achieved by focusing on a market segment called “premium class”, which covers medium class, upper medium class and luxury vehicles up to SUVs. This segment is facing severe problems in reaching European environmental exhaust targets, when running on fossil fuel only, not the least due to the considerable vehicle weight. In ADVICE three physical demonstrator vehicles are built, ranging from mild-hybrid, plug-in-hybrid to full-hybrid and – concerning fuel type – from gasoline to diesel-driven. In addition, it will be shown that the whole range in between these demonstrator vehicles can be well covered by means of validated simulation, yielding a complete coverage of the whole “premium class” segment. ADVICE aims for a reduction of exhaust and CO2 emissions on WLTP of 20% and a 25% increase in electric driving range for P-HEVs at a maximum premium cost of 5% for HEV (15% for P-HEV) with respect to the best in-class non-hybrid diesel vehicles. Particular attention is devoted to optimum driveability and drive performance, which are essential when purchasing a “premium class” vehicle and thus crucial to achieve the market penetration aimed at. These objectives will be accomplished by: * Architecture-level hybrid powertrain solutions, suited to be modularly applied to different segments to increase their volumes while reducing costs * Advanced predictive control strategies and model predictive control strategies, taking the entire vehicle into account (not only the hybrid part) * Novel optimised approaches in the aftertreatment system * Newly developed high-temperature electronics, enabling novel strategies and approaches for energy- and thermal-management * Multi-core processor architectures, enabling sophisticated control strategies and models processed on-board the vehicles ADVICE results will be verified through vehicle validator independent tests

Keywords: electrified vehicles
Strengthening international R&I cooperations between China and the EU (SENET)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Germany,Spain,Germany,China,France,France,Portugal
Call: Strategic collaboration in health research and innovation between EU and China (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 1240150.0
EU funding (EUR): 917337.5
Participants: 10
Project status: CLOSED

China and the EU have a solid framework for successful collaboration aiming at tackling common global societal challenges, such as the progress of ageing society. In addition, China and the EU are determined to intensify their cooperation via several joint flagship initiatives in a number of focus areas including biotechnologies for human health. China has been third most important international partner country in the EU Framework Programme 7. However, the global health challenges are difficult to tackle unilaterally, the research landscape is still fragmented with partly divergent research priorities and there is a current tendency of decreased Chinese participation in the EU health programmes. Therefore, a continuous and sustainable health-related research and innovation dialogue between China and the EU has to be maintained and encouraged in order to highlight and leverage on cooperation possibilities of mutual benefit. SENET - Sino-European Health Networking Hub has two main objectives: Firstly, it aims to create a sustainable health networking and knowledge hub which facilitates favourable conditions for a constant and constructive dialogue between Chinese and EU research and innovation entities. Secondly, it intends to increase collaborative efforts addressing common health research and innovation challenges. SENET’s objectives are in line with the expected impacts of the call. It intends to enhance bi-lateral and multi-lateral cooperation between EU and China on health research and innovation topics. It is determined to increase higher participation of Chinese researchers in SC1 and future EU and Chinese joint health research programmes and consequently strengthen R&I cooperation in health research and innovation. SENET is composed of a multidisciplinary team of 5 EU and 4 Chinese professionals with a long track record in their relative fields of expertise as think tank, researchers, policy analysts and trainers in health innovation and research management.

Keywords: policy dialogue,health research priorities,capacity building,awareness raising,increasing participation,closing innovation gap,international cooperation,china
Research, Connections, Networks and Culture (ReConNeCt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Serbia,Serbia,Serbia,Serbia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-10-31
Duration (months): 18.0
Total project cost (EUR): 145750.0
EU funding (EUR): 132000.0
Participants: 7
Project status: CLOSED

ReConNeCt project has the ultimate goal to unveil the true personalities of researchers and show their multifaceted, subtle and “only humans” side. This is a true challenge knowing that the researchers are usually perceived as hardcore, hard to approach loners who love to deconstruct scientific mysteries, unselfishly work for the benefit of mankind and, in a word, improve our daily lives. Being completely in line with the main common objectives of the European Researchers’ Night, ReConNeCt project, besides these highlighted objectives, puts special emphasis on the most important – the beginnings of one’s future scientific odyssey i.e. inspiring and motivating the young generations of future scientists and life-changers. The outlined concept and the content planned will help to achieve the following specific objectives: • To break and demystify the persistent and repeated stereotypes about researchers; • To bring out the actual researchers in Serbia, engage them publically and increase their recognition both in Serbia and globally; • To promote research carried out in Serbia and researchers as role models; • To unveil the motives behind becoming a researcher and entice the young to embark on scientific careers; • To show the importance of scientific research and raise public awareness of the researchers' contribution to progress and development; • To raise public awareness about the impact of researchers in ever important fields like climate changes and global warming, but also in the subtle realm such as cultural heritage (in line with celebrating 2018 as the European Year of Cultural Heritage); • To highlight the importance of the EU’s manifold support to researchers and scientific research work in Serbia; • To improve networking with other national/international projects involved in science popularization, through mutual support of events and exchange of ideas, experiences and people.

Keywords: science,hands on,connection,local,global,human side
Add medical genetic solutions to RESOLUTE (REsolution) (REsolution)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Germany,Germany,Italy,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Restricted Call to maximise impact of IMI2 JU objectives and scientific priorities (H2020-JTI-IMI2-2020-22-single-stage, 2020)
Start date: 2021-06-01
End date: 2023-12-31
Duration (months): 31.0
Total project cost (EUR): 2162500.0
EU funding (EUR): 1000000.0
Participants: 9
Project status: SIGNED

Solute carriers (SLCs) are the largest family of membrane transporters encoded in the human genome and their role in trafficking nutrients, ions, vitamins and cofactors is vital for maintaining homeostasis in individual cells, organs and tissues. Their misfunction is associated with a variety of diseases and a small number of individual SLCs are successful drug targets. Despite their importance, SLCs remain understudied and a surprisingly large proportion is deemed “orphan” in terms of transport function. The ongoing RESOLUTE IMI consortium is working on the systematic de-orphanization of SLCs and is highly successful in creating open-access tools, high-throughput assays and omics data. This effort is focused on basic aspects of SLC biochemistry and biology and was not meant to include the medical dimension. In the REsolution program we propose here, we exploit the unique opportunity to now link the RESOLUTE knowledge to physiology and disease through human genetics. The goal is to maximize the chances that SLC transporters will become successful drug targets and use the growing amount of data becoming available on genetic variations and disease association to assign pathophysiological relevance to individual transporters. Concretely, we plan to: 1) assemble human SLC genetic information and annotate within the RESOLUTE knowledgebase; 2) study the structure-activity relationship for selected SLC variants, 3) use deep mutagenesis and artificial intelligence to develop the equivalent of a “Rosetta stone” allowing the interpretation of SLC genetic variation. This will allow us to not only contextualize SLCs, as elucidated by RESOLUTE, in the current human medical genetics landscape, but also to create an SLC prioritization rationale and a resource of the whole SLC family for the pharmaceutical industry valid for years to come.

Keywords: solute carriers,drug targets,transporters,human genetics,genetic variation,disease association,deep mutational scanning,machine learning,variant effect prediction,knowledgebase
Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry (ClickGene)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Italy,Germany,Germany,Italy,Italy,Ireland,Greece,Greece,Switzerland,Czechia,Czechia,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3556990.44
EU funding (EUR): 3556990.4400000004
Participants: 18
Project status: CLOSED

Gene therapy is expected to play a key role in next-generation medicine by correcting the underlying genetic causes of disease, thereby facilitating personalised medicine. Current gene therapy methods possess undesirable side effects, including insertional mutagenesis, toxicity, low efficiency and off-target cutting. Questions also remain regarding the optimal methods for delivering nucleases into cells and tissues. These limitations will be addressed through the original and innovative approach of the ClickGene network. ClickGene’s research objectives are to train 14 ESRs in the field of biomaterials development with specific focus on, i.) site-selective genetic engineering, ii.) liposomal nanoparticle drug delivery, and iii.) optogenetic diagnostic probes for epigenetic base detection. Most of our academic partners are key members of COST Action CM1201: Biomimetic Radical Chemistry and all have outstanding international reputations as scientific leaders in their field. This COST Action will play a vital role in both networking and training elements of ClickGene, and in combination with transferable skills training, intersectorial and cross-disciplinary secondment, and industry targeted workshops, the education of biomaterials chemists with expertise in click-chemistry and cutting edge application areas of gene therapy, nanotechnology and biological diagnostics will be achieved. The training provided will match the skills required by next-generation research leaders in biopharmaceutical, nanotechnology, biodiagnostic and other industries. Allied to academic strength in this network, ClickGene features highlycompetitive industry partners with expertise in commercialisation of nucleic acid click-chemistry (baseclick, ATDBio) and liposomal and lipidome technology (LipiNutraGen). Thus, synergy between both commercial and academic partners will enable ESRs to develop gene-targeted technology within a highly productive, engaging, and exciting training network.

Keywords: gene therapy,gene editing,molecular diagnostics,drug delivery,epigenetic,artificial nucleases
Feasibility Study for a Breakthrough Core System to Enable Fault Tolerant Manufacture of High Performances Composites Wind Blades (KORIDION)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

KORIDION project is aimed to provide a simple yet effective solution, transferring positive results applied in protective equipments (helmets), to composite materials applied for wind blade structures. The advantages provided within the system enable to improve the load capacity of the structure, adhesion from skin and core, and more relevant to the end performances, to constitute a system which can be easily automated, contemporarily reducing the potential impacts of errors in manual operation. Innovative material and processing mechanisms are at the forefront of the project objectives, oriented to revolutionize the way blades are designed and manufactured. The basic KORIDION formula and the processing means have been developed within SmartNets EU project (G.A: 262806) in cooperation with the UK company Tryonic Ltd. Tryonic owns the IPR generated and THURCKON has the rights for use and further exploitation of the five patents developed. The project is expected to generate relevant growth for THURCKON that foresee to reach, in a short-medium term (2-4 years), revenue of about 2.3 M€ (low success scenario) and to hire a minimum of 4 employees. The final objective is to demonstrate the feasibility, also through a reduced scale blade application, that can effectively constitute a basis for a successful Step2 project, oriented to the successful transfer of the overall approach at a full scale wind turbine blade.

Keywords: wind blades,composite material,lightness,innovative production process,sustainable process
Migration and Transnational Social Protection in (post-)crisis Europe (MiTSoPro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-11-01
End date: 2023-02-28
Duration (months): 76.0
Total project cost (EUR): 1306717.98
EU funding (EUR): 1306717.98
Participants: 1
Project status: SIGNED

The negative employment and social developments across Europe since the start of the crisis, coupled with increased fiscal constraints and changing migration patterns, have led to increasing depictions of EU and third-country immigrants as ‘abusers’ of their social protection systems. Member States have accordingly sought reduce migrants’ ability to access social protection benefits, despite the fact that they are disproportionately at risk of poverty and social exclusion. This project looks at the different strategies that migrants have to access social protection within (post) crisis Europe and does so by explicitly integrating social policy and migration studies’ approaches on the phenomenon. More precisely, it aims to study transnational social protection, that we define as migrants’ cross-border strategies to cope with social risks in areas such as health, long-term care, pensions or unemployment that combine entitlements to host and home state-based public welfare policies and market-, family- and community-based practices. This study thus consists in, first, identifying the social protection policies and programs that home countries make accessible to their citizens abroad, and then compiling this information into an online database. We will then aggregate the results of the database into a Transnational Social Protection Index (TSPIx) in order to determine the overall level of engagement of each state with citizens abroad in a comparative way. Second, on the basis of the results of the index, we will select case studies of migrants from two EU and two non-EU countries that vary in their level of engagement in providing social protection to their citizens abroad. We will then undertake multi-sited ethnographic fieldwork to qualitatively assess the informal social protection strategies used by migrants and examine their interaction with formal host and home state social protection provision.

Keywords: migration,social protection,diaspora,welfare,european union
Energy Conversion and Information Processing at Small Scales (NanoThermo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Luxembourg
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1669028.77
EU funding (EUR): 1669028.77
Participants: 1
Project status: CLOSED

Thermodynamics provided mankind with the intellectual tools to master energy transfers and energy conversion in macroscopic systems operating close to equilibrium. It is now one of the most fundamental theories in physics. My goal is to establish a thermodynamic theory describing energy conversion and information processing in small synthetic or biological systems operating far from equilibrium. Significant progress has been achieved in this direction over the last decade. The new theory is called stochastic thermodynamics (ST). It allows us to describe and understand energy conversion in systems as diverse as quantum junctions and molecular motors, and also to predict the energetic cost of information processing operations such as erasing bits of information or feedback controlling a small device. It was validated in single molecule pulling experiments, electronic circuits, NMR and colloidal particles in optical tweezers. Nevertheless, ST still suffers from serious limitations which prevent its application in more complex systems. Therefore, I propose to expand the theoretical foundations of ST far beyond its current realm of validity and to broaden the scope of its applications in various new directions. I want to answer questions such as: Can one design devices made of many small energy converters (e.g. thermoelectric junctions) arranged in such a way as to generate collective behaviors (e.g. synchronization) prompting higher powers and efficiencies? Can one do the same by engineer quantum effects? How can one reduce the dissipation occurring when computing very quickly with small devices? Why are metabolic networks so efficient in converting energy, transmitting information, and preventing errors (e.g. toxic byproducts)? I will do so in close contact with leading experimental groups in the field. My conviction is that ST will become as important for nanotechnologies and molecular biology as thermodynamics has been for the industrial revolution.

Keywords: stochastic thermodynamics