Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of lateral diffusion of AMPA Receptors in LTP (TRAPAMPAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 167145.57
EU funding (EUR): 167145.57
Participants: 1
Project status: CLOSED

Synaptic recruitment of AMPA receptors (AMPAR) is a critical step in synaptic plasticity events such as Long term potentiation (LTP). Although the signaling events necessary for the induction of LTP are well known (i.e. NMDA receptor activation and activation of protein kinase cascades), the source of the newly inserted AMPAR is still unclear. There are two pools of AMPA receptors that can be potentially mobilized to the synapse during LTP: a pool of AMPAR-containing intracellular vesicles and a pool of membrane-located extrasynaptic AMPAR. Since recent studies carried out mainly at the host laboratory have demonstrated that extrasynaptic AMPAR are highly mobile (sometimes moving in and out of synapses), it is possible that the increases in synaptic transmission observed during LTP might be due to the diffusional trapping of passing extrasynaptic AMPAR. During this project I will use a combination of state of the art imaging and electrophysiological approaches to test the hypothesis that mobile extrasynaptic AMPAR correspond to the most immediate source for the newly inserted AMPAR during LTP.

Keywords: ampars,camkii,ltp,synaptic plasticity,lateral diffusion,quantum dots
Specialized cantilevers for cancer research (SCANCER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2010-03-01
End date: 2014-05-19
Duration (months): 36.0
Total project cost (EUR): 263296.68
EU funding (EUR): 263296.68
Participants: 1
Project status: CLOSED

Research in the mechanical properties of cells will help to develop novel techniques and methods to complement traditional methods of cancer detection and means to evaluate the efficiency of cancer drugs. The objective of this project is to achieve significant advances in such field using specific cantilevers with customized geometries, added functionalities and engineered tips. More concretely, the tip shapes will be chosen in order to increase the contact area and therefore increasing the signal to noise ratio at the moment of the indentation; the geometries of the levers (top-view design) will be improved in order to minimize the damping; and finally a self actuation mechanism will be integrated in the levers in order to minimize the fluid vibrations and therefore the noise. Finally the fabrication and use of arrays of optimized probes is planned aiming the increase of the data acquisition rate, which will enable statistical studies to consolidate the technique and the possibility of the commercialization of the prototypes All the improvements planned for the project are expected to help the development of instruments and methods to ultimately characterize cancer cells in vivo, which is the major goal within cancer detection research. The presented proposal describes an ambitious project in a crucial topic. It will start with a very basic research on cell-studies and characterization with single AFM probes and it will finish with the use of multiple probes in parallel to validate the technique. The synergies between the outgoing and return organizations and the matching of the applicant profile with the research program are optimum for a successful development of the project.

Keywords: electromechanical engineering,microsystems,nanodevices
Ubiquitination and sumoylation in modulating subnuclear localization of DNA repair (SLX5-8 IN DNA REPAIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-03-01
End date: 2011-02-28
Duration (months): 24.0
Total project cost (EUR): 180801.44
EU funding (EUR): 180801.44
Participants: 1
Project status: CLOSED

The maintenance of genomic integrity is a crucial biological process. Among the main factors influencing genome stability are DNA repair mechanisms, which are highly conserved among eukaryotes. There is a complex interplay and crosstalk among the different regulatory mechanisms that control DNA repair pathways. These mechanisms often exploit post-translational modifications such as ubiquitination and sumoylation. The recent discovery of the evolutionarily conserved family of SUMO-targeted Ubiquitin ligases (STUbL) has established a novel mode of communication between the sumoylation and ubiquitination pathways. In addition, recent evidence has implicated the sumoylation pathway and STUbLs as important players contributing to subnuclear architecture. This project aims to understand the mechanisms by which ubiquitination/sumoylation, subnuclear localization and DNA repair interface to maintain genome integrity. Recent data from the Gasser lab has identified the relocalization of damage to nuclear pores as a novel event that contributes to repair by a complex of nuclear pores and Slx5-Slx8 (the budding yeast STUbL). This proposal will focus on the characterization of molecular mechanism through which Slx5-Slx8 regulates DNA repair. We want to understand how ubiquitin/SUMO modification affects eukaryotic nuclear organization during DNA repair. We combine yeast molecular genetics, biochemical methods and quantitative live fluorescence imaging approaches to address these questions at a molecular level.

Keywords: slx5-slx8,dna repair,subnuclear localization,ubiquitin,sumo,sumo-targeted ubiquitin ligases (stubls),molecular biology,cell biology
International sensor development network (SENSENET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom,Germany,Germany,Germany,France,France,Sweden,Denmark
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-06-01
End date: 2013-05-31
Duration (months): 48.0
Total project cost (EUR): 3751495.77
EU funding (EUR): 3751495.77
Participants: 10
Project status: CLOSED

This ITN project will train young investigators to enable them make significant advances in the field of in situ sensor technology. It will bring together 15 research groups and 2 industrial partners from across the European Union. The ITN will provide training for 16 PhD students, early stage researchers (ESRs) and 1 Postdoctoral student, experienced researcher (ER). The programme will combine the strengths of the leading marine and engineering research groups in the EU, and through a structured and extensive programme of collaboration and student exchange, will provide a powerful, cohesive marine sensor development programme. Fundamentally, the outcome of this ITN will be to equip Europe with a network of young scientist/engineers, who will share a common technical culture and approach, and who will ultimately enable the monitoring of our fragile yet rapidly changing marine environment.

Keywords: biogeochemistry,sensors,marine technology sensors and instrumentation
Paleogeography of the Paratethys: Relation to hydrocarbon source rock quality (PARATETHYS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-06-01
End date: 2012-05-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The Neogene Paratethys successions of Central Europe and the southern Caucasus are considered as important source rocks for hydrocarbons. Due to different regional biostratigraphic stages used for potential source rock successions, paleoenvironmental correlations remain enigmatic and hydrocarbon source rock formation is poorly understood. The goal of this project is to reconstruct the Eocene to Miocene paleogeographical and environmental evolution for the Central and Eastern Paratethys in the framework of forcing contributions of tectonics and climate. To accomplish this goal, the marine and estuarine successions of the Maikop series of the Greater Caucasus, the Tard Clay of the Pannonian Basin, the Menilite Shales of the Carpathian Foredeep, the Bulgarian Ruslar Formation, and of the Alpine Foreland Basin will be studied using a multidisciplinary research approach. This approach includes: (1) Combining biostratigraphic data with a variety of geophysical, geochemical, stable isotope (C, N, O), and organic (Rock-Eval) analyses (2) Detailed characterization of the molecular composition of organic matter (e.g. maturity, facies, origin) in source rocks and hydrocarbon reservoirs (3) Compound-specific C-isotope analyses on biomarkers; H- and C-isotopic composition of oil and gas (4) Basin models for hydrocarbon generation The results of this approach will allow to constrain the influence and interaction of the controlling factors on changes in biological communities, water exchange and formation of natural resources in intra-continental basins. Reconstruction of the thermal evolution of hydrocarbon source rocks and of charging events will enhance our understanding on the pre-conditions and generation of petroleum deposits within the prospective areas. The results are expected to contribute to the understanding of the petroleum systems and, therefore, increase the successful exploration and sustainable exploitation of hydrocarbons.

Keywords: geomorphology,tectonics,biogeochemistry,petroleum geology,petrochemistry
Non commutative geometry and quantum gravity (QGNC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-03-16
End date: 2012-03-15
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The project aims at deepening the relationship between various approaches to quantum gravity and noncommutative geometry. Indeed there is a strong theoretical evidence that the usual continuum model of space-time is not correct at very short distances where both gravitational and quantum mechanics effects come into play. Several theories propose a (incomplete) treatment of quantum gravity, but even the most popular of them (string theory, loop quantum gravity) have not been experimentally tested for the energy scale corresponding to the Planck length is far beyond our experimental possibilities. However it has been stressed that quantum gravity theories, by giving a non continuum structure to space-time, may lead to some observational effects. Most of the time this non continuum structure has a mathematical translation in terms of quantum, or non commutative, spacetimes. Namely one posits a noncommutative algebraic structure of the coordinates of spacetime by a deformation of the classical algebra, just as quantum groups are deformation of classical Lie algebras. However the physical status of such space-times is not clear. Naive questions like "what are the points of a quantum space-time ?", "what happens to the notion of distance ?" have no clear answer. These questions are addressed by the conceptual approach to Noncommutative Geometry (NCG) developed by Connes. NCG provides a formulation of standard geometric and topological concepts (like spin and differential structures) within a purely algebraic framework. Riemannian geometry is encompassed as a particular case, commutative, of a more general theory. The project aims at deepening the relation between the more down-to-earth-approach to quantum space-time developped by theoretical physicist on the one side, and the more fundamental (but difficult) theory of Connes on the other side. It is a continuation of EIF fellowship made by Martinetti in Amelino-Camelia`s group in Rome in 2006/08.

Keywords: mathematical physics,quantum field theory,gauge theory,differential geometry,unification of interactions
A Clostridal Biology Network to Facilitate European-wide Medical Countermeasures and Commercial Exploitation (CLOSTNET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom,Germany,Germany,Finland,Italy,France,France,United Kingdom,Slovenia,United Kingdom,Netherlands
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-09-01
End date: 2013-08-31
Duration (months): 48.0
Total project cost (EUR): 4811791.0
EU funding (EUR): 4811791.0
Participants: 13
Project status: CLOSED

There is an urgent need to better understand the basic biology of Clostridium as a prerequisite for both countering the diseases they cause (C.difficile, C.perfringens and C.botulinum), and exploiting their beneficial properties in industry (biofuels by C.acetobutylicum) and medicine (cancer therapy by C.sporogenes). Attainment of this goal is being impeded because: (i) European research efforts are fragmented; (ii) there is no coherence between researchers working on pathogenic species and industrially important strains; (iii) there is a demonstrable (SCF-CT-2005-029958) lack of trained young clostridial researchers; (iv) there is inadequate networking between industry and academia, and; (v) effective exploitation of the amassed clostridial genome data has been precluded by a woeful inadequacy in procedures for gene inactivation. Removal of these impediments cannot be achieved at a national level, but requires the creation of a transnational network of multi-disciplinary experts,active in different scientific sectors. The technical hurdle to progress has now been solved by partner 1, who has developed a highly effective andreproducible gene knock-out system. The remaining hurdles will be overcome by bringing together a multidisciplinary team of research expertise from 7 different EU states drawn from Academia (5), Government (3) and different sectors of Industry (3). A principal focus will be to address the deficiency in critical mass by providing young researchers with world class, state-of-the-art, multidisciplinary training in leading scientific and biotechnological skills that have relevance to medical countermeasures against pathogens and the exploitation of non-pathogens in industrial processes and disease intervention. These measures will establish Europe as a ‘Centre of Excellence’ for clostridial research, propelling the community to the forefront of the field, eclipsing the efforts of the rest of the world, and in particular the USA and Japan.

Keywords: infections,diagnostics,anticancer therapy,microbiology,biofuels,biotechnology
Control of Light Use Efficiency in Plants and Algae - From Light to Harvest (HARVEST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands,France,United Kingdom,Germany,Netherlands,United Kingdom,Germany,Hungary,Finland,Sweden,Italy,Netherlands,Czechia
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 4683560.0
EU funding (EUR): 4683560.0
Participants: 15
Project status: CLOSED

Photoprotection against excess absorbed light energy is an essential and universal attribute of oxygenic photosynthetic organisms. This requirement has been a strong force in the evolution of plants and micro-organisms, and a diverse range of solutions have arisen. It has determined survival, productivity and habitat preference, and it determines the ceiling on the efficiency of energy conversion in photosynthesis in natural environment. Its investigation also provides insights into unique nanoscale switching processes. Understanding the molecular mechanisms of biological light adaptation will therefore have implication for many aspects of life, such as agriculture and food security, biodiversity and global climate change, biosolar energy and biofuels. This network brings together major high-quality EU centres with expertise in a wide range of disciplines – from plant physiology to molecular biology, structural biology and photophysics – and with great interest in interdisciplinary collaborative research. The network will thus provide a unique training opportunity for young researchers in key aspects of molecular biosciences and biophysical sciences in the context of practical applications in instrument development, agronomy, ecology and biotechnology. Researchers from within and outside this network will receive key research skills from several disciplines combined in a high-level and intrinsically collaborative research project, key transferable skills on information technology, written and oral communication and critical assessment, and key business and commercial skills on commercial exploitation and product development.

Keywords: photosynthesis,fluorescence,photoprotection,non-photochemical quenching,carotenoids,femtosecond spectroscopy,systems biology,biofuel technology,horticulture,agriculture,biotechnology
Nucleosome Structure & Function across Biological Scales and Biological Function (NUCLEOSOME4D)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,Norway,France,Hungary,Switzerland,Denmark,Spain,Austria,Israel,United Kingdom,United Kingdom,France,Germany,Germany,United Kingdom,Italy
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 4609511.0
EU funding (EUR): 4609511.0
Participants: 17
Project status: CLOSED

Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand how nucleosome structure is established, maintained and manipulated. Our Marie Curie Initial Training Network will carry out multidisciplinary, collaborative research projects focused on deciphering nucleosome structure and function in space and time (Nucleosome4D). Our main objective is to provide our young researchers with world-class research &amp; training in nucleosome biology. We will use cutting-edge, interdisciplinary methods and collaborative projects to determine how nucleosomes are remodeled during transcription, when genes are silenced, as cell divide, as stem cells differentiate, during organismal development and in human disease. We utilize state-of-the-art approaches in structural biology, biophysics, cell biology, live-cell imaging, biochemistry, genetics, genomics and bioinformatics. We will implement a comprehensive training plan for scientific and career development using the best local approaches to research &amp; training, by promoting exchanges, using the advise of our industrial partners and three Visiting Scientists, by sharing reagents and expertise, as well as through a structured set of scientific workshops and complementary skills training courses. Together, our effort will ensure the multidisciplinary and intersectorial training of a new cohort of young European researchers. This will allow our trainees to take the opportunities and meet the challenges of a successful career in the life science sector through excellent training, effective communication, great teamwork and proven project management skills.

Keywords: cell biology,computational biology,embryology,structural biology,developmental biology,genomics,molecular biology,immunology,genetic engineering,cytology,proteomics,biochemistry,enzimology
Membrane Enhanced Tide Synthesis - A New Paradigm Peptide / Oligonucleotide Synthesis Technology (MEMTIDE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Finland,Spain,United Kingdom,Switzerland,Belgium
Call:  (FP7-PEOPLE-ITN-2008, 2008)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 2329000.0
EU funding (EUR): 2329000.0
Participants: 7
Project status: CLOSED

The MemTide Initial Training Network will create a new generation of synthesis technologies for peptide and oligonucleotide (“tide”) manufacture, with focus on the use of emerging membrane technology to effect critical separations. New nanofiltration membranes with improved chemical stability, and closely controlled molecular discrimination properties, will be developed. Novel synthesis strategies for tides, which utilise membranes for key separations will be created. MemTide will consider both step change improvements to solid phase tide synthesis, and the realisation of a completely new concept of tide synthesis based on solution phase synthesis coupled to membrane purification. The applications of these technologies will be through the industrial partners. The project is multidisciplinary, involving chemists, materials scientists and chemical engineers. The consortium is intersectorial, comprising 3 universities/research institutes, a technology SME, a fine chemicals company and a large pharmaceutical manufacturer, and will have a strong emphasis on knowledge creation, technology commercialisation, and entrepreneurship. The training programme involves Early Stage Researchers (ESR), at both university and industrial partners, each of whom will complete a PhD thesis through a combination of local and network wide research experience. Experienced Researchers (ER) will complete their training through development of entrepreneurship and project management skills. ESR and ER will complete complementary training through a series of Personal Skills Modules, and a course on Technology Commercialisation and Entrepreurship. MemTide seeks to contribute to improving the European knowledge supply chain through this industry-academia programme aimed at developing engineers and scientists who are academically excellent and achieve PhD degrees, but who thrive at the interface between fundamental research and industrial application.

Keywords: technological sciences,engineering,chemical engineering,chemistry,peptide and oligonucelotide synthesis