Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Contextual specification of fibroblast-driven causalities in chronic intestinal inflammation and fibrosis (BecomingCausal)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Greece
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 2411000.0
EU funding (EUR): 2411000.0
Participants: 1
Project status: SIGNED

Inflammatory bowel disease (IBD) is a severe, chronic pathology presenting with progressive intestinal inflammation and fibrosis, whose exact causes and key pathways remain poorly defined. Stromal–immune cell interactions have recently gained momentum in conceptualizing tissue homeostasis and our lab offered solid evidence establishing fibroblast heterogeneity and dominant roles in intestinal pathophysiology. Our recent preliminary evidence, indicated diverse spatial distribution of subsets of activated fibroblasts and revealed synergistic interplays of important inflammatory pathways driving pathogenicity. Detailed insights into such contextual complexities remain obscure. Here, we propose a novel unifying hypothesis that progressive IBD is orchestrated by specific subsets of fibroblasts, becoming causal to pathogenesis, depending on contextual information dictated by origin, topology, and cross-talks with immune or stromal cell types. We propose to use single-cell spatiotemporal phenotyping to deconvolute fibroblast subset-specific functions in disease-staged, fibrotic and non-fibrotic animal models of IBD. We aim to: (1) Map dynamic chromatin and gene expression programs that define cellular heterogeneity and infer cell interactions to build an ‘IBD connectome’ atlas (2) Analyse the origin, spatial distribution, plasticity and lineage trajectories of intestinal fibroblasts and reveal potential functions of pathogenic subsets (3) Perform discovery screens and functional validations on known (TNF, IFNγ, TGFb and interleukins) and novel fibroblast-subset-specific pathways focusing on potential synergistic interplays (4) Employ clinical material to validate involvement of the most prominent new pathways in human. The proposed research should help tackle the complexities of chronic inflammatory and fibrotic disorders in the intestine and beyond, advance mechanistic concepts in immune disease pathophysiology and promote fibroblast-targeting therapeutic discovery.

Keywords: mesenchymal,fibroblast,single cell,spatiotemporal,disease mechanisms
COntroller adaptive Digital Assistant (CODA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Italy,France,Spain,Netherlands,Belgium,Canada
Call: ATM application-oriented Research for Connected and Automated ATM (HORIZON-SESAR-2022-DES-ER-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 2149690.0
EU funding (EUR): 1929486.0
Participants: 9
Project status: SIGNED

COntroller adaptive Digital Assistant The CODA project involves developing a system in which hybrid human-machine teams collaboratively perform tasks. To do so, the system put together state of art from different fields: i) Prediction models to foresee future situations and have the system know which activities will be carried out by the operators and their impact on the same human performance; ii) Neurophysiological assessment of mental states to enable the system to know operators’ real current level of workload, attention, stress, fatigue, and vigilance by validating the predicted cognitive models and maximising the effectiveness of the interaction between the human and the machine by developing an HMPE (Human Machine Performance Envelope); iii) AI-based adaptable and explainable systems, to have the system act to prevent future performance or safety issues. Specifically, the project will show how a system could adapt to specific situations and react accordingly by using advanced adaptable and adaptive automation principles that will dynamically guide the allocation of tasks. The system will assess the operator's cognitive status, use current traffic data to foresee the future tasks that the operator will need to perform in the future, and calculate the impact of those tasks in terms of cognitive complexity. With this information, the system will predict the future mental state of the operator and will act accordingly by developing an adaptive automation strategy. For example, imagine an ATCO managing a complex traffic situation and experiencing a medium workload. The system is aware of this (thanks to the neurophysiological assessment). It predicts that the additional upcoming tasks the ATCO will need to take care of will increase their workload, exceeding the maximum an operator can handle. To avoid this, the system decides how to act, following an adaptation strategy: it may, for instance, increment the level of automation, enable additional AI-based tools, or request a sector splitting.

Keywords: digital assistant,human ai teaming,adaptive automation,human machine performance envelop hmpe,predictive models
New generation single-shot LiDARs with the PicoAD monolithic detector (PicoAD_LiDAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Light Detection and Ranging (LiDAR) is a remote sensing technology that measures object distances by analyzing the time-of-flight of photons. LiDARs emit short laser pulses, detect their reflections, and precisely measure travel time. Using a pixel matrix sensor, they can generate detailed 3D images, used for e.g. autonomous vehicles, industrial automation, robotics, and augmented reality. Despite being a rapidly growing emerging market, current LiDAR technology is still far from being fully developed. In particular, next-generation LiDAR sensors must achieve greater background light rejection to operate in complex conditions as well as reduced latency to enable real-time detection capabilities. This project will build upon the patented Picosecond Avalanche Detector (PicoAD), developed within the MONOLITH ERC_AdG project. It will design and validate a proof-of-concept PicoAD version specifically tailored for LiDAR applications. This version will enable fast analog signal filtering at the pixel level and precise time gating to detect only photons from the laser pulse. Thereby it will suppress background light noise far more effectively than current methods and improve reliability in adverse ambient conditions. Unlike conventional LiDAR sensors that rely on multi-shot measurements, our PicoAD will enable single-shot photon detection, dramatically enhancing acquisition speed. This will provide significant advantages for applications requiring real-time decision making such as collision avoidance in autonomous vehicles. Robust circuits will be designed to function across a wide temperature range from -40°C to 125°C. In addition, the high-speed electronics will incorporate multiple-return processing, enabling the detection of multiple reflections from a single laser pulse. This capability will enhance depth perception in complex environments, including scenarios with partially overlapping objects, highly reflective materials, or fog.

Keywords: photon detection,time of flight,background light rejection,real time detection,single shot measurement,multiple return processing,autonomous vehicles,depth perception
Pan-Africa network for genomic surveillance of poverty related diseases and emerging pathogens (PANGenS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Germany,Ghana,Netherlands,Mozambique,Tanzania, United Republic of,Namibia,Nigeria,Gabon,Benin,United Kingdom,Switzerland,South Africa
Call: Genomic epidemiology for surveillance and control of poverty-related and emerging/re-emerging infections in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-07-01
End date: 2027-06-30
Duration (months): 48.0
Total project cost (EUR): 4998433.75
EU funding (EUR): 4998433.25
Participants: 13
Project status: SIGNED

The main aim of the proposed project is to use genomic epidemiology of tuberculosis, malaria and emerging and re-emerging pathogens in Africa as to better understand disease etiology, dynamics of disease transmission, and evolution of drug-resistant pathogens. The study also aims to increase Africa's capacity in bioinformatics, genomics, genomics data management, biobanking, and promote data sharing. Our goal is to improve the health of Africans with innovations in disease surveillance, equip the next generation of African scientists with cutting edge skills and strengthening south-south research collaborations. We propose the following hypotheses: 1. Increased capacity in genomic epidemiology will enable more effective disease surveillance in Africa. 2. Increased capacity in biobanking and genomics data management and analysis in Africa will enhance regional surveillance of infectious diseases and encourage timely and effective responses to emerging pathogens. 3. Regional whole genome sequence-based surveillance will improve the detection of DR-TB and inform the development of more sensitive and specific rapid diagnostics for the detection and surveillance of DR-TB in Africa and elsewhere. 4. Regional genomic surveillance of malaria parasites will inform a pre-emptive detection of emerging DR parasites and measure the impact of programmatic interventions for a data driven decision making by policy makers. 5. Implementation of harmonized genomic data analysis tools will allow the creation of continent-wide surveillance networks able to identify cross-border spread of DR variants and emerging pathogens. To achieve this, PANGenS will develop genomic epidemiology capacity across Africa by establishing a collaborative framework that brings together all expertise to perform trainings and implementation in all relevant components ranging from wet lab to bioinformatics, and establish proof-of-concept studies for TB and malaria in in selected partner countries

Keywords: tuberculosis,malaria,integrated molecular surveillance,drug resistance
The Ungovernable City: Interest Groups and Local Political Institutions in the United States and Europe (TUC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

As nations in the developed world strive to reduce carbon dioxide emissions to counteract the effects of climate change, transitioning from more carbon intensive cities to greener modes of housing and transportation will become paramount challenges for governments throughout the 21st century. The United States, who produces about 11 percent of CO2 while accounting for just two percent of the world’s population, presents a particular challenge. Infrastructure costs in the United States are astronomically higher than in comparable developed nations in Europe or Asia. Further, housing construction—especially dense urban housing and its accompanying low carbon profile—is nearly impossible to build in almost all major American metro areas due to restrictive land use policies, an abundance of veto points exploited by engage local interest groups and America’s strong federalist institutions that give deference to local governments when deciding land use policy. This project seeks to understand how interest groups in the United States capture local housing and land use policymaking and why a similar phenomenon hasn’t evolved in many European Union nations. Studying local interest groups in a comparative setting will better illuminate how weaknesses in political institutions engender this behavior and lead to differing outcomes between the two regions. Identifying these institutional deficiencies will also aid reforms in the United States crucial for modernizing that democracy and aiding the global fight against climate change. This project will also deepen understanding of how interest groups form and evolve, what motivates the transition from individual financial motivation to the formation of an interest group and how these groups capture local political institutions.

Keywords: housing,land use policy,urban studies,local government,political institutions,public policy
ADVANCED SAFER MATERIALS AND HIGH PERFORMING CELLS FOR THE NEXT GENERATION OF LI-ION BATTERIES SUITABLE FOR MOBILITY APPLICATIONS (SAGELI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: France,Germany,Spain,Belgium,Italy
Call: New Approaches to Develop Enhanced Safety Materials for Gen 3 Li-Ion Batteries for Mobility Applications (Batt4EU Partnership) (HORIZON-CL5-2023-D2-02, 2023)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 4975670.75
EU funding (EUR): 4975669.75
Participants: 13
Project status: SIGNED

SAGELi aims to develop safer materials and cells that meet Batteries Europe’s 2030 targets for safety, performance, lifetime, sustainability and cost including EUCAR level <3. SAGELi’s new cathode active materials (CAM) contain no Co. They are based on inherently-safe Mn-rich oxides. Additional safety will be ensured by reducing CAMs’ active surface area and an innovative coating. SAGELi’s safer binders target better adhesion, lower swelling and better processability to prevent safety issues from cracking and inhomogeneities. SAGELi’s flame-retardant electrolytes target stability at high voltage. SAGELi’s Flash Thermal Test will predict safety from just a few grams of novel materials, eliminating the need for upscaling to determine safety. SAGELi’s State of Safety Early Prediction Tool will predict EUCAR level during battery operation and ageing. SAGELi’s pouch cells will be demonstrated at 25 mAh and 5 Ah scale, and all SAGELi materials and cells are fully scalable and recyclable via existing processes. The consortium gathers (i) 5 top public research organisations whose previous results have been used in commercial batteries (CEA, FZJ, CNRS, CID, CICe); (ii) 7 companies committed to bringing SAGELi to market in existing and future factories across the EU for sales to customers worldwide: Umicore for CAM, Arkema for binder and electrolyte, Ccell for cells, Power4Future for batteries, FINCANTIERI for electric ships and THALES for electric aircraft equipment; and (ii) EU electromobility association, AVERE. SAGELi’s raw material cost is 23% lower than NMC811. SAGELI’s market penetration in 2030 is expected to generate ~1.4 bn€ of revenues for SAGELi’s EU partners by 2030 and >20.2bn€ in 2035. Its materials are expected to be used in 40GWh of batteries produced in 2030, 600GWh produced in 2035, and 700 GWh produced in 2040, providing a cumulative 1.9Mt C02eq savings vs NMC811. Preliminary LCA also predicts reduced water use, other emissions and land-use vs NMC811.

Keywords: safer batteries,lithium ion battery,cathode active materials,mn rich oxides,hlm,drs,binder,electrolyte,modelling,safety,lca,safe by design,sustainable by design,electromobility
TechConnect: Assessing and Strengthening Human-Tech Skill Complementarity in the Digital Landscape (TechConnect)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Ireland,Sweden,Spain,Netherlands
Call: Assessing and strengthening the complementarity between new technologies and human skills (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 2993360.0
EU funding (EUR): 2993360.0
Participants: 9
Project status: SIGNED

TechConnect thoroughly explores the ongoing debate regarding the influence of emerging technologies on human labor and skills. It places a distinct emphasis on Human-Tech Skill Complementarity, highlighting the essential interdependence and mutual enhancement of both human and technological skills in a systemic manner. The primary goal is to deepen our understanding of the dynamic interplays between new digital technologies and human skills, generating novel and practical knowledge on this emerging topic of Human-Tech Skill Complementarity. The project brings together a multidisciplinary team and employs diverse methods, including policy analysis, systematic literature review, annual cross-sectoral industry landscape surveys, in-depth case studies in the healthcare sector and validating the findings beyond this sector via stakeholder engagement, workshops, and guidelines production. The key outcomes include the development and validation of the Human-Tech Skill Complementarity Conceptual Framework, Assessment Index, Strengthening Model, and TechConnect Stakeholder Toolkit. These outcomes reveal the how new technologies such as AI and robotics affect human skills, emphasising the development and deployment of technologies that enhance individual skills and workforce capabilities. Adopting a collaborative approach, TechConnect forms a consortium with academics, industry partners, and a stakeholder engagement firm. This collaborative effort fosters partnerships with technology associations, professional groups, and government entities. Grounded in the research-informed, evidence-based and practice-driven approaches, TechConnect will make a meaningful impact on the quality of employment and competitiveness, contributing to social and economic resilience. The collective efforts of the consortium are geared towards disseminating findings and recommendations widely, with the ultimate goal of influencing policy and practice for inclusive growth in the digital landscape.

Keywords: human tech skill complementarity conceptual framework assessment index strengthening model driving changes scaling job quality improved work conditions
Unveiling Earth’s Critical Resources for Clean Energy and a Sustainable Future (EarthSafe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands,Spain,Italy,Australia,United States,United Kingdom,Belgium,Jordan,Germany,Canada
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 2097900.0
EU funding (EUR): 2097900.0
Participants: 13
Project status: SIGNED

The coming decade will be a defining test for humanity and its capacity to respond to unprecedented global challenges. To meet the demands from the energy transition and related green technologies, the current global supply of critical minerals will have to quadruple by the end of 2040. Likewise, the EU2030 goal to create a more resilient energy plan with minimum dependency on fossil fuels, creates an enormous demand for alternative, greener and sustainable energy sources. Among these, deep geothermal energy has the highest potential for long-term, large-scale supply of energy for heating and generation of electrical power. In response to these pressing needs, the EarthSafe Doctoral Network will develop an innovative and efficient data-fusion paradigm to enhance the effectiveness of exploration efforts for deep geothermal resources and critical materials, robust to data missing limitations. EarthSafe will achieve this ambitious goal by harnessing i) the complementary strengths of multiple satellite and land-acquired datasets and ii) a novel combination of artificial intelligence, probabilistic inverse theory, computer modelling and science communication. Holistic training of Early Stage Researchers in these powerful disciplines will prepare them to addressing the most critical challenges that our society will confront in the next decades, making them highly attractive to both the academic and non-academic sectors. By formally embedding innovative science communication strategies, EarthSafe will create a new dimension of engagement with the general public and policy makers worldwide. Given its global scope, EarthSafe will support the creation of new energy and economic opportunities in vulnerable societies, helping them to tackle inequality and energy poverty while at the same time consolidating Europe’s innovation and technological capacity. In doing so, EarthSafe will contribute to, and is perfectly aligned with, the main objectives of the European Green Deal.

Keywords: lithosphere,geodynamics,model order reduction,deep geothermal exploration,mineral systems