Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A cost effective, smart, calibration free, low maintenance pH sensor providing an integrated approach to monitoring sea and drinking water, facilitating improvements in ocean, animal and human health. (pHenom)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the pHenom project is to produce the next generation pH sensor capable of accurate, calibration free and smart operation, with integral quality and control. Development and commercialisation of this smart sensor, named the “pHenom” will provide a revolutionary pH sensor that meets the ocean monitoring and water management needs. Beyond the ocean monitoring and water management industries, the global pH meter market is expected to reach nearly £1.48 bn by 2022. The pH meter market is segmented into bench top (55% share - £815m), portable, and continuous pH meters. pHims technology can deliver to all three and has the potential to meet a wide range of needs within the segments; pharmaceuticals and biotechnology, food science (41% share), water and waste treatment, research institutes and environmental control boards. Despite US dominance, in 2014, Europe was the highest revenue generating region at 32% due to the high level of R&D activities, advanced healthcare, and industrial infrastructure. Drivers are new technology (microprocessors for auto temperature and pressure compensation), growing health concerns and regulatory pressure to monitor environmental pollution (waste water pH in industries such as chemicals, pharmaceuticals, food processing) and the need to regulate pH levels (routine testing of soil, water, food, beverage, and dairy products). The objective of this feasibility study is to carry out activities that enable the provision of a comprehensive feasibility report with conclusions, recommendations and a specification of the Phase 2 project objectives, together with a detailed marketing and business plan for the development and commercialisation of pHims.

Keywords: sensor,ocean,water management,treatment,quality,environment,monitoring,resources
Palaeolithic Micro-botanical remains as a proxy for Human Occupation Intensities (PaleoMicroBot)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-15
End date: 2019-01-14
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The present project aims to use the microbotanical remains content in the sedimentary record to study site occupation intensity as a proxy for demographic changes during the Middle to Upper Paleolithic (MP-UP) transition. PalaeoMicroBot will develop new methods to obtain high-resolution data by incorporating the last developments in geoarchaeology, palaeobotany and archaeology. The objective is to study the phytolith, micro-charcoal, starch grain, and mineral composition in well-studied archaeological sites where the late MP and early UP layers are found in stratigraphic succession: La Ferrassie and Les Cottés. In addition, complementary sites with similar characteristics will be tested to provide a larger-scale perspective to the MP-UP transition. The sedimentation rate, sediment diagenesis, paleo-climatic changes, and the taphonomy and distribution of the microbotanical remains will be analyzed in order to evaluate the extent of the anthropogenic impact in the exposed profiles. The microbotanical results will be integrated with the macro-archaeological record and on-going analyses at the sites using state-of-the-art GIS methods. The results obtained will be tested against the additional sites in order to define chronological and geographical variations. Finally, several models to explain the MP-UP transition will be developed using the data obtained in this project and in the literature. These models will be tested using advanced multivariate statistics in order to detect first, the existence of effective changes in the site occupation intensities, and second the importance of the demographic variable in the MP-UP transition. The PaleoMicroBot project aims to contribute to the debate of the demise of the Neanderthals and the arrival of the first Anatomically Modern Humans by using a groundbreaking methodological approach, and doing so, to add a new line of evidence to the study of demographic changes in European Prehistory.

Keywords: phytoliths,starch grains,microcharcoal,ocupation intensity,middle to upper paleolithic transition,neanderthal,anatomically modern humans
The Prodrobot authomatized gait trainer software developement and the EU market research (We teach to walk)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Poland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Prodromus Sp. z o.o. (Ltd.) is the only manufacturer of The Prodrobot authomatized gait trainer, a medical robot which can teach to walk and to correct impaired gait of children. We invented, developed and produced fully working device which is dedicated to all rehabilitation facilities all over the World. It is much smaller, much lighter and much cheaper than competitors machines. It offers many unique features and exercises, unachievable for other market solutions. It is computer controlled. It uses simple and intuitive software for users (simple like an ordinary cash mashine). We won many medical and bussines awards in Poland. Last year and this year we showed it at the international fair in Łodz (in Poland, we won the Gold Medal in 2015) and Dusseldorf (in Germany). We intend to sell The Prodrobot all over the World, beggining from our local market, and the EU market. Last year we made a pilot sale and after 14 months of using it by professional users we made some updates to our robot and its software. Now, we are ready to prepare launch sales in many other countries. We collect a lot of international contacts but had no sufficient resources to continue software development dedicated for many countries all over the World. We collect Letters of intention from distributors and rehabilitation centers. We plan to make market research in countries in the EU at first, because we have to fullfill authorisation issues in other countries, which takes time. We need to know what are total costs of the launch of sales in a given country inside and outside the EU. We also need to secure our IP in other countries before we start to sell. Our last targets are: to gain new sales partners in the EU and to build service network for our products. Prodromus is EN ISO 13485 certified company and Prodrobot 93/42/EEC certified product (CE mark for medical devices), registered by the Polish Office for Registration of Medicinal Products, Medical Devices and Biocidal Products.

Keywords: prodrobot,children gait rehabilitation,lower limbs diseases,steering software,celebral palsy,spinal,cord injury,medical device,robot,exosceleton,orthosis,movable orthosis
Sino-European innovative green and smart cities (SiEUGreen)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Innovation actions
Countries involved: Germany,Cyprus,China,Türkiye,Norway,Sweden,Switzerland,Türkiye,Bulgaria,Greece,Greece,Denmark
Call: Resource-efficient urban agriculture for multiple benefits – contribution to the EU-China Urbanisation Partnership (H2020-SFS-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 8377867.5
EU funding (EUR): 6999999.38
Participants: 21
Project status: CLOSED

SiEUGreen aspires to enhance the EU-China cooperation in promoting urban agriculture for food security, resource efficiency and smart, resilient cities. Building on the model of zero-waste and circular economy, it will demonstrate how technological and societal innovation in urban agriculture can have a positive impact on society and economy, by applying novel resource-efficient agricultural techniques in urban and peri-urban areas, developing innovative approaches for social engagement and empowerment and investigating the economic, environmental and social benefits of urban agriculture. In order to achieve its objectives, SiEuGreen brings together a multi-disciplinary Consortium of European and Chinese researchers, technology providers, SMEs, financiers, local and regional authorities and citizen communities. The project consists in the preparation, deployment and evaluation of showcases in 5 selected European and Chinese urban and peri-urban areas: university in Norway, community gardens in Denmark, previously unused municipal areas with dense refugee population in Turkey, big urban community farms in Beijing and Central China. Throughout SiEUGreen’s implementation, EU and China will share technologies and experiences, thus contributing to the future developments of urban agriculture and urban resilience in both continents. The impact measurement during and especially beyond the project period is a key component in the project’s design. Information and results obtained from the project will be disseminated through diverse communication and dissemination tools including, social media, an innovative app enhancing urban co-design, stakeholder conferences, hand-on training workshops, showcase demonstration forums, municipality events. A sustainable business model allowing SiEUGreen to live beyond the project period is planned by joining forces of private investors, governmental policy makers, communities of citizens, academia and technology providers.

Keywords: resilience,smart cities,inclusion,social innovation,eu china cooperation,food security,food literacy,resource efficiency,land use,urban design,environmental and economic impact
BioMusical Instrument (BioMusic)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-05-01
End date: 2019-10-31
Duration (months): 18.0
Total project cost (EUR): 149901.0
EU funding (EUR): 149901.0
Participants: 1
Project status: CLOSED

The BioMusical Instrument project will create a product prototype of a wearable digital musical instrument based on biosignals from the performer’s muscles. It will allow musicians to perform electronic sounds from bodily gestures. Muscle tension will be sensed by innovative new electromyogram sensing hardware packaged in an ergonomic housing and coupled to wireless communication. Sophisticated machine learning methods developed in the ERC MetaGesture Music and H2020 Rapid-Mix projects will track musician gesture and create meaningful relationships with computer-based synthesized sound. The BioMusical Instrument will be marketed to three distinct application areas: First, it will enable “hands-free” performance of electronic music. Second, the visualization of body states will make it a useful training tool in traditional musical instrument pedagogy. Finally, the sonification of physiological signals will allow the instrument to be used in the health sector in physical rehabilitation exercises. The BioMusical Instrument will be the first product to combine EMG sensing, machine learning, and advanced audio signal processing. We have identified partners in the biomedical hardware field, the music technology industry, and rehabilitation research with whom we will benchmark and evaluate the product prototype.

Keywords: wearable,digital musical instrument dmi,embodied human computer interaction hci,human interface device hid,biosensing,electromyogram,gesture,machine learning,synthesizer,performance
Tumor Endothelial Cells: Gatekeepers Of Anti-Tumor Immunity (TESTIMONY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Immunotherapy, in the form of immune checkpoint inhibitors, is the upcoming anti-cancer therapy, but suffers resistance in large fractions of cancer patients (also lung cancer). Tumors stimulate angiogenesis to ensure their supply of nutrients, however much less studied is how tumor endothelial cells (TECs) contribute to immunosuppression. Endothelial cells (ECs) represent a major non-hematopoietic component of immunity and TECs are presumed to be immunosuppressive, in part by expressing elevated levels of PD-L1. However, the role and dynamics of TEC-expressed PD-L1 in anti-tumor immunity relative to the cancer expressed PD-L1 remain incompletely understood. Given the strategic “1st line” location of TECs, the question raises if at least part of the success of PD-L1 inhibition, is attributable to an effect on TEC immunity. Therefore, for the 1st time, I will fill this gap of knowledge by characterizing mice lacking PD-L1 in ECs and assess tumor progression and anti-tumor immunity in these mice using different tumor models. I will assess the efficacy of anti-PD-L1 blockade in mice lacking PD-L1 in ECs in different stages of tumor growth to delineate the dynamics of PD-L1 expression in TECs. Moreover, by using established in vitro approaches, I will study the effect of PD-L1 knock-down in human lung tumor derived TECs vs. normal ECs on human T cell proliferation, effector function and transmigration. The proposed research provides unprecedented insights in the relative role of tumor endothelial vs. cancer cell-derived PD-L1 in immunosuppression. This is a multi-disciplinary project at the interface of angiogenesis, immunology and cancer. Combining my expertise on T cell biology with the host’s expertise in angiogenesis and exceptional scientific infrastructure (core facilities) and innovative science (EC:T cell interactions during immunotherapy) will ensure successful achievement of the project goals and provide a highly competitive training for my future career.

Keywords: tumor immunity,endothelial cells,t cells,immunotherapy,immune checkpoint proteins
SYSTEM ARCHITECTURE AND CONCEPTUAL DATA MODEL FOR RAILWAY, COMMON DATA DICTIONARY AND GLOBAL SYSTEM MODELLING SPECIFICATIONS (LINX4RAIL2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Italy,Germany,Belgium,Sweden,Sweden,Belgium,France,France,France,United Kingdom
Call: Evolution of Railways System Architecture and Conceptual Data Model (CDM) (H2020-S2RJU-CFM-2020, 2020)
Start date: 2020-12-01
End date: 2023-05-31
Duration (months): 30.0
Total project cost (EUR): 1921243.57
EU funding (EUR): 1401128.75
Participants: 23
Project status: SIGNED

European Railway operators are under pressure to decrease their life cycle cost, to increase significantly their reliability and punctuality, to be more adaptive to different services. The European railway system remaining very fragmented in terms of technologies, the adoption of new technologies and the renewal of former technologies are not quicker enough for the railway mode to answer rightly to the public policy needs. Research and innovation has a part to play in achieving these goals by giving to the datas and their models and further the definition of a global railway system architecture as it is developing in other transport modes and industries the relevant roles that will support the necessary evolutions. The undergoing LinX4Rail project sets the grounds for a shared vision of the railway system architecture, as well as the development of the Conceptual Data Model (CDM) which will enable different simulation or operational subsystems to run together, which paves the way to building a shared and interoperable architecture. The objectives of LINX4RAIL-2 are: • To manage the follow-up of the existing work on System Architecture and Conceptual Data Model (CDM) carried out in the on-going LinX4Rail project, aiming at a large adoption for the European railways sector, • To ensure wider uptake of results from LinX4Rail by proving the performance of the proposal methodology and vision and by evaluating the impacts, taking into account the business case, • To establish a single ‘repository’ for System Architecture and CDM with a well-developed sustainability plan, • To adopt a common vision for the functional railway vision able to transform the Europe railway system.

Keywords: system of systems,system architecture,interoperable architecture,conceptual data model,data dictionary,modelling specification,digital twin,governance,semantic,standardisation
MEtal NAnoClusters for Electrocatalytic CO2 conversion (MENACE-CO2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-05-12
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Combatting the menace of global warming requires solutions to recycle carbon dioxide (CO2). Electrochemical (EC) CO2 reduction reactions (CO2RR) could potentially solve this problem by the storage of energy from renewable sources in the form of chemical energy in fuels or value-added chemicals in a sustainable manner. However, CO2 is a highly stable molecule and catalysts are needed to overcome its kinetically sluggish reduction. Despite the considerable progress in the design of metallic nanoparticle (NP) catalysts, the polydispersity of conventional NPs limits the fundamental understanding of structure-activity relationships, which remains the bottleneck for further catalyst development. To overcome this problem, I propose the utilization of a novel class of catalysts that lie in the transition regime between small molecules and NPs: Atomically precise ligand-protected metal nanoclusters (MNCs). Contrary to NPs, MNCs are monodisperse particles with a defined composition that can be structurally characterized at the atomic level. The aim of this project is to develop the full potential of MNCs for catalytic EC CO2RR i) by studying MNC structure-activity relationships, including size, protecting ligands and metal composition; ii) by tuning their catalytic performance, modifying MNCs with molecular metal-oxides to enhance CO2 adsorption; and iii) by their immobilization into nanocarbon materials, improving catalyst stability and performance due to the synergy between the support substrate and supported catalyst. The goal of the MENACE-CO2 project is to shed light into the precise correlation of structure with catalytic properties, enabling the rational optimization of this novel type of catalysts. Moreover, this project will open new perspectives by engineering nanocomposites, recognizing the roles of each component and how they synergize to achieve their properties to, ultimately, open new directions in CO2 conversion.

Keywords: nanoclusters,metals,polyoxometalates,carbon dioxide,electrocatalysts,electrochemical co2 reduction,structure activity correlation,nanoengineering,graphene,and carbon nanotubes
Cellular and Biophysical Approach to Understand the Cytokine-mediated Regulation of the Lysosomal Hydrolytic Capacity (CytoLysoReg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Dysfunction of lysosomes—the recycling plants of cells, now recognised to participate in multiple aspects of cell physiology—is involved at the onset of several human diseases. Importantly, most of the functions carried out by lysosomes depend on hydrolytic activities within their lumen. Thus, a deeper understanding of the signalling pathways involved in the regulation of lysosomes would provide new tools to ameliorate the symptoms associated with these diseases. The regulation of lysosomal gene expression was partially elucidated by the discovery of the role played by the mTOR-TFEB axis during starvation. However, as recently shown by the researcher (Nature Comm 2018) and others the cytokines-STAT3 axis also contributes to lysosomal regulation. However, the molecular mechanisms of the cytokine-mediated lysosomal regulation still remain unresolved. Thus, the herein proposed project (CytoLysoReg) is aimed at unveiling the molecular and biophysical properties allowing cytokines to regulate lysosomes. CytoLysoReg is an innovative, multidisciplinary project based on international collaborations and preliminary data generated by the researcher during his work as Senior Research Associate at the University of Dundee. The data generated during the execution of CytoLysoReg on lysosomal regulation will allow us to manipulate lysosomes as an approach to treat lysosomal-related diseases (e.g. cancer, LSDs). The role of Prof. Diaz-Quintana as supervisor will be essential, providing his expertise in biophysics and protein structure, and facilitating the integration of the researcher into the host institution (IIQ-Seville). Finally, after finishing the MSCA-IF fellowship, the researcher will be invited to develop his independent scientific career and reinforce the Biological Chemistry line—considered a strategic research line to be developed at the host institute—at the IIQ-Seville thanks to the ongoing MSCA Fellows Stabilisation and Recruitment of Talent Programme of the US.

Keywords: lysosome regulation,cytokines,cell signalling,phosphoproteomics,metabolomics