Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Revealing the immune tumor microenvironment (iTME) in melanoma by multiplexed imaging (ImageMelanoma)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2026-06-30
Duration (months): 66.0
Total project cost (EUR): 1613750.0
EU funding (EUR): 1613750.0
Participants: 1
Project status: SIGNED

Immunotherapies targeting immune regulators are revolutionizing cancer treatment, most prominently in melanoma, but only for a subset of patients. While it is known that the immune tumor microenvironment (iTME) plays a vital role in this process, there is limited understanding on how distinct tumor, immune and stroma cells interact as a system to collectively define progression and response to treatment, and there is no biomarker to predict patient response. Tumors are spatially organized ecosystems that are comprised of distinct cell types, each of which can assume a variety of phenotypes defined by coexpression of multiple proteins. To underscore this complexity, and move beyond single cells to multicellular interactions, it is essential to interrogate cellular expression patterns within their native context in the tissue. We have recently pioneered MIBI-TOF (Multiplexed Ion Beam Imaging by Time of Flight), a novel platform that enables simultaneous imaging of forty proteins within intact tissue sections at subcellular resolution. We propose to (1) Use MIBI-TOF to chart the iTME in dozens of clinical samples from melanoma patients and delineate its function in response to different immunotherapies. (2) Profile murine melanoma tumors to elucidate genetic and temporal mechanisms that drive iTME organization in vivo. (3) Develop new experimental tools for tracing and barcoding thousands of cells to decouple the effects of tumor genetics and the immune microenvironment on tumor organization and clonal dynamics. (4) Develop machine-learning-based algorithms to analyze this novel data and facilitate accessibility of the scientific community to high-dimensional imaging to study human malignancies. This proposal applies state-of-the-art imaging technology and computation to unravel design principles of the iTME in melanoma, with a grand goal to reveal basic principles in tumor immunology and improve treatment and diagnostics.

Keywords: multiplexed imaging,proteomics,melanoma,immunotherapy
User-centric solutions for a flexible and modular manufacturing in small and medium-sized shipyards (Mari4_YARD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Germany,Italy,Spain,Spain,Germany,Spain,Italy,Greece,Greece,Croatia,Poland,Belgium,Netherlands,Netherlands,Portugal
Call: Improved Production and Maintenance Processes in Shipyards (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2020-12-01
End date: 2024-11-30
Duration (months): 48.0
Total project cost (EUR): 5913440.0
EU funding (EUR): 4998824.76
Participants: 18
Project status: SIGNED

EU shipbuilding leading edge relies in the complexity, quality, customization, delivery time and lifecycle services (e.g. in situ maintenance, repair and retrofitting) of the vessels manufactured. However, in the last decade, EU small and medium-sized shipyards (SME) have experienced a competitive drawback in their market segments due to an increase of competition from other global regions that benefits from lower labour costs or higher automation degree. Moreover, SME shipyards must also overcome a major impediment related with capital investment that can overwhelm the part cost for shipbuilding. As a result, current automation solutions based on large monolithic equipment, are not still valid for increasing productivity in SME shipyards. Therefore, shipbuilding, and especially SME shipyards, needs novel cost-effective, reconfigurable, modular and flexible worker-centric methodologies capable of improving worker’s performance and ensuring quality and precision in the execution of the labour-intensive tasks. Mari4_YARD aims the implementation of a portfolio of worker-centric solutions, by relying on novel collaborative robotics and ubiquitous portable solutions, enabling modular, reconfigurable and usable solutions targeting the execution of labour-intensive tasks by preserving industry-specific workers’ knowledge and skills. Moreover, replicability and early-adoption of the portfolio of technologies by other SME-shipyards is ensured through several actions on training, technology assessment, benchmarking… by establishing a pan-European network of Didactic Factories, offering general-purpose testbeds and showrooms, as well as providing upskilling and re-skilling of shipyards workforce. To further maximise the impact, Mari4_YARD plans to use synergies with complementary European and national initiatives, especially those related to MG-3-7-2020. A strategy for collaboration with Mari4_CHAIN and Mari4_PRO proposals, if funded as well, has already been set up.

Keywords: worker centric solutions portfolio,novel collaborative robotics,handheld and portable augmented reality solutions,ai assisted exoskeletons,modular and flexible manufacturing
PhenoMeNal: A comprehensive and standardised e-infrastructure for analysing medical metabolic phenotype data (PhenoMeNal)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Austria,Germany,Italy,Germany,Sweden,Switzerland,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Managing, preserving and computing with big research data (H2020-EINFRA-2014-2, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 8005909.75
EU funding (EUR): 7684919.75
Participants: 15
Project status: CLOSED

In the coming decade a significant number of the 500.000.000 European (EU/EEA) citizens will have their genome determined routinely. This will be complemented with much cheaper (currently ~20 Euro per measurement) acquisition of the metabolome of biofluids (e.g. urine, saliva, blood plasma) which will link the genotype with metabolome data that captures the highly dynamic phenome and exposome of patients. Having such low cost solutions will enable, for the first time, the development of a truly personalised and evidence-based medicine founded on hard scientific measurements. The exposome includes the metabolic information resulting from all the external influences on the human organism such as age, behavioural factors like exercise and nutrition or other environmental factors. Considering that the amount of data generated by molecular phenotyping exceeds the data volume of personal genomes by at least an order of magnitude, the collection of such information will pose dramatic demands on biomedical data management and compute capabilities in Europe. For example, a single typical National Phenome Centre, managing only around 100,000 human samples per year, can generate more than 2 Petabytes of data during this period alone. A scale-up to sizable portions of the European population over time will require data analysis services capable to work on exabyte-scale amounts of biomedical phenotyping data, for which no viable solution exists at the moment. The PhenoMeNal project will develop and deploy an integrated, secure, permanent, on-demand service-driven, privacy-compliant and sustainable e-infrastructure for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering research and clinic.

Keywords: metabolomics,personalised medicine
Deep non-invasive imaging via scattered-light acoustically-mediated computational microscopy (DYNA-MIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-09-30
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Optical microscopy, perhaps the most important tool in biomedical investigation and clinical diagnostics, is currently held back by the assumption that it is not possible to noninvasively image microscopic structures more than a fraction of a millimeter deep inside tissue. The governing paradigm is that high-resolution information carried by light is lost due to random scattering in complex samples such as tissue. While non-optical imaging techniques, employing non-ionizing radiation such as ultrasound, allow deeper investigations, they possess drastically inferior resolution and do not permit microscopic studies of cellular structures, crucial for accurate diagnosis of cancer and other diseases. I propose a new kind of microscope, one that can peer deep inside visually opaque samples, combining the sub-micron resolution of light with the penetration depth of ultrasound. My novel approach is based on our discovery that information on microscopic structures is contained in random scattered-light patterns. It breaks current limits by exploiting the randomness of scattered light rather than struggling to fight it. We will transform this concept into a breakthrough imaging platform by combining ultrasonic probing and modulation of light with advanced digital signal processing algorithms, extracting the hidden microscopic structure by two complementary approaches: 1) By exploiting the stochastic dynamics of scattered light using methods developed to surpass the diffraction limit in optical nanoscopy and for compressive sampling, harnessing nonlinear effects. 2) Through the analysis of intrinsic correlations in scattered light that persist deep inside scattering tissue. This proposal is formed by bringing together novel insights on the physics of light in complex media, advanced microscopy techniques, and ultrasound-mediated imaging. It is made possible by the new ability to digitally process vast amounts of scattering data, and has the potential to impact many fields.

Keywords: optical microscopy,light in complex media,scattering,optical wavefront shaping,super resolved imaging,compressive sensing
Multifuel, Economic, High Efficiency High Thermal Power Rotating Biomass Burner for Industrial Applications (BioBur)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The food and beverages processing sector (FBP) is the largest manufacturing industry in South East Europe in terms of regional turnover and employment accounting for 27% of turnover and 18% of employment in manufacturing . About 80% of the total energy associated with the entire food life cycle is originated from fossil fuels. In terms of Greenhouse Gases (GHG) food consumption in 2013 has led the average EU citizen to emit the equivalent emissions from travelling about 22.800km by car . Consequently, the sector is looking for energetic alternatives 1) With high efficiency performance; 2) Reducing their dependency to fossil fuels, 3) Incorporating their business models to the circular economy approach, 4) Reducing their operational costs with more cost-effective fuels and resilient to market price fluctuations, 5) With a fast and easy integration and relatively short pay-back. Current solutions are mainly based in Grate-fired boilers that are simple and admit different types of feedstock but presents limitations in terms of the high space it needs, its low efficiency and high emissions. Other recent approaches have separated the burner from the boiler even though normally provide no much power, only use one type of biomass, presents low efficiencies (<90%) and require high maintenance. Natural Fire, leader of bakery biomass burner market industry in Europe, aims to accelerate the commercialization of a multifuel biomass rotating burner (BioBuR) which is high efficient (up to 98%), high compact (50 % reduction in size) and economic (up to 75 % price reduction) when comparing with grate-fired solution; by scaling it up to 3-10 MW and able to substitute to the fossil fuel burners within the FBP industry (saving up to 4 times operational costs and reducing also their GHG).

Keywords: burner,biomass,efficiency,multifuel,industrial
Epigenetics, Experience and Responsibility: Implications for neurodevelopmental disorders (NEUROEPIGENETHICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Belgium,Belgium
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1453012.0
EU funding (EUR): 1390512.0
Participants: 2
Project status: SIGNED

In folk psychology and in bioethical discussions, the central dogma of genetics is often taken for granted: humans are seen as defined in a genetic blueprint. The conceptualization of psychiatric conditions as innate or acquired, biological or psychosocial, genetic or environmental, influences the ascription of both capacity responsibility (the capacity to adapt or adjust one’s own behavior) and normative responsibility of individuals or the society towards those diagnosed. But findings in the field of epigenetics indicate that the social and physical environment influence how genes are expressed. Indeed, epigenetics may shed a new light on distinctions such as innate/acquired, genetic/environmental, biological/psychosocial: a far more complex view on neurodevelopmental disorders may emerge, with ethical implications. However, the implications of epigenetics for discussions on the scope and extent of normative responsibility have not been adequately addressed. NEUROEPIGENETHICS aims to investigate the ethical implications of epigenetics for neurodevelopmental disorders. We will use theoretical and empirical methods to investigate how certain concepts (innate/biological/genetic) affect the ways in which professionals and stakeholders (persons with a neurodevelopmental disorder and their families) conceive of responsibility. We will evaluate how the emerging field of epigenetics alters the ascription of capacity responsibility and normative responsibility. We will research how individuals with Autism Spectrum Disorder (ASD), Tourette Syndrome (TS) and Attention Deficit Hyperactivity Disorder (ADHD)and their families experience the interaction between their condition and their biological and social environment. Finally, we will define moral responsibility in light of the emerging field of epigenetics in the area of neurodevelopmental disorders and child psychiatric practice.
ERA-NET Cofund on ICT-enabled agri-food systems (ICT-AGRI-FOOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: ERA-NET Cofund
Partnership: ICT-AGRI-FOOD (ERA-NET)
Countries involved: Spain,Estonia,Ireland,Austria,Germany,Estonia,Ireland,Italy,Israel,Germany,Greece,Switzerland,Norway,Türkiye,Belgium,Bulgaria,Finland,Hungary,Poland,Sweden,Belgium,Romania,Latvia,France,France,Netherlands,Denmark
Call: ERANETs in agri-food (H2020-SFS-2019-1, 2019)
Start date: 2019-10-01
End date: 2025-03-31
Duration (months): 66.0
Total project cost (EUR): 15151515.18
EU funding (EUR): 5000000.0
Participants: 36
Project status: SIGNED

This proposal responds to topic “SFA-31-2019 A” of the work programme 2018-2020 of societal challenge 2 under Horizon 2020. The overall objective of “ICT-enabled agri-food systems” is strengthening the cooperation in research, development and innovation between EU Member and associated States to foster, verifiably and perceptibly, the use of smart digital technology to make European food systems more sustainable, resilient and secure. With financial support of the European Commission (EC), the proposing consortium will organise and fund joint calls for transnational research projects on an annual basis. Funded research projects will contribute to introducing and exploring digital technology that enhances the sustainability of the agri-food sector to the benefit of our and future generations. Beyond co-funded calls, other joint activities in this thematic area will be implemented, thus contributing to the establishment of a fair and societally accepted bioeconomy in the EU and beyond. The consortium will intensify, broaden and deepen the successful cooperation established in the framework of its predecessor FP7 ERA-NET; ICT-AGRI-2.

Keywords: public public,smart systems,farm to fork,agri food,implementation,sustainability,intelligent machines,big data
Protection and control of Secured Information by means of a privacy enhanced Dashboard (PoSeID-on)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Ensure privacy and freedom, including in the Internet and enhance the societal, legal and ethical understanding of all areas of security, risk and management
Action type: Innovation actions
Partnership: Cybersecurity PPP (cPPP)
Countries involved: Austria,Spain,Italy,Italy,Spain,Spain,Malta,Belgium,France,Netherlands,Portugal
Call: Cybersecurity PPP: Privacy, Data Protection, Digital Identities (H2020-DS-SC7-2017, 2017)
Start date: 2018-05-01
End date: 2021-03-31
Duration (months): 35.0
Total project cost (EUR): 3072586.27
EU funding (EUR): 2541208.75
Participants: 15
Project status: CLOSED

PoSeID-on is aimed at developing a novel Privacy Enhancing Dashboard for personal data protection supporting the pillars of the new EU’s General Data Protection Regulation (GDPR) with regards to digital security, that will be implemented within a single, integrated tool, adopting blockchain and smart contracts technology. It will provide targeted benefits for final end users by enabling data protection by design and by default. In particular, the project will deliver an easily accessible and simple privacy enhancing dashboard useful for monitoring, keeping track record, and controlling all aspects related to data subjects personal data, privacy settings, eventually deciding to authorize/un-authorize personal data transfers. Thus, the primary aim of PoSeID-on is empowering data subjects in having a concise, transparent, intelligible and ease access, as well as tracking, control and management of their personal data processed by public and private organizations, acting as data controllers and/or data providers. They will be able to make conscious decisions on who can process their own data based on data controller trustworthiness, enabling or revoking permissions, asking for definitely remove their personal data or restricting the data to be shared following the data minimisation principle. A risk management framework will be integrated into the privacy enhancing dashboard. As secondary aim, PoSeID-on will support the compliance of technological services and products with the GDPR regarding personal data, by integrating advanced ICT-based tools within a replicable and scalable frame, which can be implemented within a broad spectrum of products and services. Moreover, personal data exchanges across data subjects and different organisations (public & private) or among organizations in case of involved third parties will take place in a secure and privacy-compliant way, generating benefits thanks to the adoption of more streamlined procedures.

Keywords: right of access,rectification,to be forgotten,restriction of processing,data minimisation,blockchain,smart contract,cloud,artificial intelligence
Fast Response Circuits for Voltage Droop Compensation (FastVolt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany,Germany,Germany
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 3855.0
Participants: 3
Project status: CLOSED

Voltage droops are unpredicted drops in the supply voltage of computer chips, which often occur as a result of nearby bursts of high intensity circuit activity. This proposal is concerned with fast voltage droops, where voltage drops within a few clock cycles. This means that any dynamic response must take place within one or at most two clock cycles. A promising direction for combining the advantages of a stable reference clock with a small response time are mixed-signal control loops, in which voltage measurements are digitized and control decisions are taken by digital logic. However, digitally measuring a dynamically changing voltage may cause metastability of the sampling circuit. Conventional approaches employ synchronizers to make the probability of metastable upsets negligible, which costs 2-3 clock cycles of additional delay. Based on results of the ERC starting grant project "A Theory of Reliable Hardware,'' we provide a simple, compact circuit that guarantees the desired behavior without incurring synchronizer delay. This yields a practical method for adaptive response to fast droops, which bears the promise of increasing computational efficiency. Conservative estimates suggest performance improvements of at least 5%, which would be of substantial economical interest. The main obstacle to commercialization is a gap between theory and practice: Without an existing implementation, it takes a long time to develop a product and the associated risks are high. In this project, we will overcome this hurdle by developing, producing, and evaluating an Application-Specific Integrated Circuit (ASIC) demonstrator for our approach. We complement this primary goal by tasks aiming at maximizing impact: publication of results in high-profile scientific venues, patent protection to facilitate commercialization, and outreach to potential industry partners for developing products.

Keywords: metastability containment,voltage droops,mixed signal control loops