Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synaptic Dysfunction in Alzheimer Disease (SyDAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Sweden,Belgium,Slovakia,Sweden,France,Luxembourg
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-11-01
End date: 2019-10-31
Duration (months): 48.0
Total project cost (EUR): 3846736.44
EU funding (EUR): 3846736.44
Participants: 11
Project status: CLOSED

Given an overwhelming increase of dementia costs and an aging population, there is an urgent need for finding novel therapies for Alzheimer Disease (AD). We are, however, facing a large number of failed clinical trials and a retraction of the nervous system R&D programmes from several big pharmaceutical companies. Increased collaboration between academia and the private sector is required to overcome this challenge. The “Synaptic Dysfunction in Alzheimer Disease” (SyDAD) project will significantly contribute to this approach by training a new generation of researchers with experience and full understanding of the requirements of academia, pharmaceutical companies, the clinics and the society. The research programme will focus on synaptic dysfunction, the main connection point between pathology and cognitive decline in AD. Given the complementary expertise, SyDAD will have excellent opportunities to delineate the cross-talk between different pathways underlying synaptic dysfunction in AD and to identify novel pharmaceutical targets. For future implementation of the research findings into clinical trials, a drug discovery platform will be elaborated, utilising the industrial and clinical expertise in the network. The early-stage researchers (ESRs) will be trained in this environment and provided with a mind-set of future commercial and clinical utilisation of their research findings. Apart from the innovative and collaborative approach of the research programme, the ESRs will also be provided with a training programme where cutting-edge methodology, innovation and transferable skills are key components. The trained ESRs will have excellent intersectoral and interdisciplinary career opportunities and will, together with the SyDAD partners, provide a solid ground to tackle one of the major societal challenges of our century: Finding therapies to decrease the suffering and economic burden of AD patients.

Keywords: synapse,alzheimer disease,cognition,memory,electrophysiology,drug discovery,biomarkers
The impact of intra household decision making on the sustainability, efficiency and equitability of household farming in sub-Saharan Africa. (INTRACOF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

This research project will assess to what extent more participatory intra household decision making about production and resource allocation contributes to more sustainable, efficient and equitable household farming systems in sub-Saharan Africa, more specifically coffee farming systems in Uganda and Tanzania. An intervention in which household are intensely coached in participatory decision making about production, resource allocation and income expenditure will be randomly introduced among Ugandan and Tanzanian smallholder coffee farming household. A framed economic experiment will permit to appraise if provision and appropriation behaviour by spouses in households with more participatory intra household decision making, the treatment group, is more cooperative, than in control households. The impact of participatory intra household decision making on the sustainability, efficiency and equitability of the outcomes from provision and appropriation behaviour in household farming systems will be studied with using individual survey data collected among spouses in treatment and control households. Inspired by the methods and findings of this project, a practical monitoring tool will be developed to capture changes in intra household decision making about production and resource allocation and their effect on sustainable, efficient and equitable (coffee) farming in collaboration with one of the partner organisations.

Keywords: intra household,household farming systems,sub saharan africa,experiment
CLOTH manIpulation Learning from DEmonstrations (CLOTHILDE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Spain,Spain
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 2499149.0
EU funding (EUR): 2499149.0
Participants: 2
Project status: SIGNED

Textile objects pervade human environments and their versatile manipulation by robots would open up a whole range of possibilities, from increasing the autonomy of elderly and disabled people, housekeeping and hospital logistics, to novel automation in the clothing internet business and upholstered product manufacturing. Although efficient procedures exist for the robotic handling of rigid objects and the virtual rendering of deformable objects, cloth manipulation in the real world has proven elusive, because the vast number of degrees of freedom involved in non-rigid deformations leads to unbearable uncertainties in perception and action outcomes. This proposal aims at developing a theory of cloth manipulation and carrying it all the way down to prototype implementation in our Lab. By combining powerful recent tools from computational topology and machine learning, we plan to characterize the state of textile objects and their transformations under given actions in a compact operational way (i.e., encoding task-relevant topological changes), which would permit probabilistic planning of actions (first one handed, then bimanual) that ensure reaching a desired cloth configuration despite noisy perceptions and inaccurate actions. In our approach, the robot will learn manipulation skills from an initial human demonstration, subsequently refined through reinforcement learning, plus occasional requests for user advice. The skills will be encoded as parameterised dynamical systems, and safe interaction with humans will be guaranteed by using a predictive controller based on a model of the robot dynamics. Prototypes will be developed for 3 envisaged applications: recognizing and folding clothes, putting an elastic cover on a mattress or a car seat, and helping elderly and disabled people to dress. The broad Robotics and AI background of the PI and the project narrow focus on clothing seem most appropriate to obtain a breakthrough in this hard fundamental research topic.

Keywords: assistive robotics,robotic manipulation,deformable object modeling,learning from,demonstration,computational topology,rgb d vision,probabilistic planning,textile industry,clothing business
ClearSalmonLice (ClearSalmonLice)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Faroe Islands
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Frama is seeking phase 1 funding in order to assess the commercial feasibility of ClearSalmonLice - a new sustainable solution to combat the dreaded Sealice and Salmon lice. ClearSalmonLice is aiming to offer a sustainable, cost-efficient and highly scalable solution to meet producers' demand for combatting lice in aquaculture production of Atlantic salmon. At present, producers lose 9 per cent every year to lice, equivalent to an annual loss of € 400 mill. At the same time, producers spend more than € 300 mill. to combat sea and salmon lice by using chemical and biological remedies with very severe consequences for nature in coastal zones, especially shell fish such as lobster and shrimps. Frama provides a natural solution without use of chemical and biological remedies. By utilising physical features of mass and density the salmon is guided through a low cost floating device containing fresh water in which lice cannot live. A patent application of our prototype has already been filed. The feasibility study is intended to assess the commercial viability and marketability of the prototype system. In particular, client feedback to optimize the solution and establish key operational parameters, verifying the appropriate business model and searching potential partners. If the study is positive, a Phase 2 application will be considered to take the project into scale.

Keywords: sustainability,aquaculture,salmon production
Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands (Cytokine Signalosome)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-09-30
Duration (months): 66.0
Total project cost (EUR): 1687500.0
EU funding (EUR): 1687500.0
Participants: 1
Project status: CLOSED

Cells use an intricate network of intracellular signalling molecules to translate environmental changes, sensed via surface receptors, into cellular responses. Despite their prominent role in regulating every aspect of life, we lack a comprehensive understanding of how signalling networks convey extracellular information into specific bioactivities and fate decisions. To rationally manipulate cell fate, which could fundamentally change the way that we treat human diseases, first we need a systematic understanding of how signalling is initiated and propagated inside the cell. I discovered that specificity of cytokine receptor signalling not only depends on cellular determinants such as receptor density and endocytic trafficking, but can be systematically altered by modulating ligand binding parameters and receptor binding geometries. A fundamentally novel approach combining high-throughput flow cytometry and QMS with engineered cytokine surrogate ligands able to fine-tune signalling responses will generate detailed maps of the signalling networks engaged by cytokines in time and space to unveil the mechanistic basis that allow a receptor to trigger different signal activation programs and bioactivities in response to different ligands. By quantitatively characterizing the signalling programs activated by ligands, using state-of-the-art biochemical, biophysical, structural, genetic and fluorescence imaging techniques, I plan to identify events critical for cellular decisions. By fully characterizing the intracellular signalling network hard-wired inside a cell and understanding its dynamic in response to environmental changes will we be able to comprehend and manipulate the enormous functional plasticity exhibited by cells. TInsights generated will open new fields of investigation where engineered ligands prove indispensable to understand complex biological responses and greatly advance our understanding of cytokine biology and human immunology in health and disease.

Keywords: protein engineering,surrogate ligands,cytokines,signallosome
Optical Infrared Coordination Network for Astronomy (OPTICON)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Australia,Ireland,Italy,Germany,Germany,Germany,Spain,Spain,Spain,Italy,Belgium,Poland,Greece,Hungary,Sweden,France,France,France,France,France,United States,Netherlands,Netherlands,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 10011619.61
EU funding (EUR): 10000000.0
Participants: 45
Project status: CLOSED

Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europe’s nations. OPTICON has a proven record supporting European astrophysical excellence through development of new technologies, through training of new people, through delivering open access to the best infrastructures, and through strategic planning for future requirements in technology, innovative research methodologies, and trans-national coordination. Europe’s scientific excellence depends on continuing effort developing and supporting the distributed expertise across Europe - this is essential to develop and implement new technologies and ensure instrumentation and infrastructures remain cutting edge. Excellence depends on continuing effort to strengthen and broaden the community, through networking initiatives to include and then consolidate European communities with more limited science expertise. Excellence builds on training actions to qualify scientists from European communities which lack national access to state of the art research infrastructures to compete successfully for use of the best available facilities. Excellence depends on access programmes which enable all European scientists to access the best infrastructures needs-blind, purely on competitive merit. Global competitiveness and the future of the community require early planning of long-term sustainability, awareness of potentially disruptive technologies, and new approaches to the use of national-scale infrastructures under remote or robotic control. OPTICON will continue to promote this excellence, global competitiveness and long-term strategic planning.

Keywords: astronomical research infrastructures,integrating activity,trans national access,sustainability,networking,technological development,community training,innovation,disruptive technology
Developing metrics and instruments to evaluate citizen science impacts on the environment and society (MICS)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Research and Innovation actions
Countries involved: Italy,Romania,Hungary,Netherlands,United Kingdom,United Kingdom
Call: Exploring and supporting citizen science (H2020-SwafS-2018-1, 2018)
Start date: 2019-01-01
End date: 2022-07-31
Duration (months): 43.0
Total project cost (EUR): 1944428.0
EU funding (EUR): 1944428.0
Participants: 6
Project status: CLOSED

THE MICS project brings together a transdisciplinary team to address a scientific and policy priority area where citizen science has the potential to promote a paradigm shift. Nature-based solutions (NBSs) are actions to protect, sustainably manage and restore natural or modified ecosystems that address societal challenges and provide human well-being. NBSs have increasingly become policy and planning objectives, but major knowledge gaps in NBSs science have hindered their implementation and acceptance. This is largely due to a lack of locally specific information about the influence of: climate, location, condition and management on NBS function and impact. Furthermore, the sustainability of NBSs often depends on the perceptions and needs of stakeholders, including user groups, local communities, conservation bodies, farmers, land managers, policy makers and practitioners. Due to their systemic complexity and embedding in local context, NBSs offer a unique potential for citizen science to make a major contribution. The MICS project will support NBS research by developing strategies and tools to evaluate impacts on science and society resulting from the integration of citizen science. These tools will foster citizen science approaches that increase both scientific knowledge, and how scientific evidence is taken up by communities and policy makers. MICS will use novel impact-assessment metrics and instruments that measure costs and benefits of citizen science in relation to the NBSs, with particular attention in the domains of society; democracy; the economy; NBS science, and citizen scientists. These instruments will be grounded in a comprehensive conceptual framework and integrated into an open platform following rigorous validation in key pilot sites along a West-East EU axis. This will test the applicability of the MICS impact-assessment tools in regions with differing opportunities and constraints for NBSs, and with different levels of citizen science uptake.
Identifying the Impact of Asylum Polices on Refugee Integration and Political Backlash in Host Communities (INTEGRATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 1486730.0
EU funding (EUR): 1486730.0
Participants: 1
Project status: SIGNED

Confronted with the largest refugee crisis since the Second World War, European governments are struggling with a complex and urgent question: how to best facilitate the integration of increasing numbers of refugees, while mitigating political conflict and native backlash in host communities? Despite the importance of this question, we lack reliable causal evidence of the impact of the asylum process and the consequences of most integration programs. The goal of INTEGRATE is two-fold. First, to provide systematic evidence that identifies the causal effects of the key parameters of the asylum process on the short and long-term economic, educational, health, political and social integration of refugees, their families, and children in five European countries: Denmark, France, Germany, Sweden and Switzerland. Specifically, INTEGRATE will examine the impact of wait times, labor market access, apprenticeship and training programs, early enrolment in language courses, integration contracts, welfare support, and family reunification policies on integration trajectories. INTEGRATE will achieve this goal by utilizing quasi-experimental research designs and by combining the coverage of high-quality register panel data with comprehensive integration measures from targeted surveys. Second, INTEGRATE will assess whether effective integration programs alleviate hostility and moderate support for extreme-right parties in host communities by leveraging policy-induced temporal and spatial variation in integration success. In so doing, INTEGRATE endeavours to shed light on the potential of asylum and integration policies to improve social cohesion and lesson refugee-native conflict. In sum, the goal of INTEGRATE is to use causal research designs and innovative statistical methodology to comprehensively evaluate the asylum process in Europe, establishing an evidence base that can be used to redesign the asylum process to improve outcomes for both refugees and host societies.

Keywords: asylum process,refugee integration,political backlash,extreme right parties
SMARTER Finance for Families–Improving Citizens’ Health, Comfort and Financial Well-Being by Supporting Banks, Residential Investors and Solution Providers with Green Homes and Green Mortgage programs (SMARTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Ukraine,Ireland,Italy,Bosnia and Herzegovina,Poland,Slovakia,Belgium,Bulgaria,Greece,Türkiye,Romania,Georgia,Czechia,Denmark
Call: Innovative financing for energy efficiency investments (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-05-15
End date: 2021-11-14
Duration (months): 30.0
Total project cost (EUR): 1618195.4
EU funding (EUR): 1618195.4
Participants: 18
Project status: CLOSED

Many citizens, particularly in nascent green building markets, make suboptimal decisions in the design and construction choices for renovation approaches and new home purchases due to a fear of bank financing. Borrowing sufficiently to bring forward necessary resources to build homes properly both reduces citizens’ “Total Cost of Monthly Ownership” (loan payment plus energy, health and repair costs) while unlocking a critical increase of construction budgets facilitating ownership of the greenest, high-quality homes. Financing Green Homes with the borrower subject to lower monthly operating costs is less risky to banks which provide discounted credit without harming profits. The SMARTER project effectively communicates the benefits of Green Homes to citizens and other key stakeholders to bring a systemic solution to a systemic problem that inhibits the financial industry to design and offer green finance products and the citizens to understand and request them. SMARTER replicates a successful “Green Homes and Green Mortgage” program to 12 new countries, addresses barriers and brings green innovation with relevant research and cluster formation, adapts essential tools for administration and communication, and effectively expands collection of actual energy and financial performance to improve risk analysis with local data. Public investment is leveraged and ambitious green EU targets are supported as banks, developers, and green solution providers all contribute budgets to increase private financing for building exemplary homes. The SMARTER “Green Homes Investment Platform” guides new programs to a suitably ambitious, common definition of green investments and facilitates institutional investment by collaborating with ongoing initiatives including EeMAP and EEFIG; aligning with EC objectives such as “Mainstreaming Energy Efficiency Finance” and advancing the Financial, Technical and Behavioral de-risking championed by “Smart Finance for Smart Buildings".

Keywords: green finance,green mortgage,nzeb homes,green homes,energy efficiency finance,green residential,green housing,green cluster,green investment,sustainable investment,green bonds