Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Parallel network-based biocomputation: technological baseline, scale-up and innovation ecosystem (Bio4Comp)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Germany,Sweden,Sweden,United Kingdom
Call: FET Proactive: emerging themes and communities (FETPROACT-2016, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 6084949.0
EU funding (EUR): 6084949.0
Participants: 6
Project status: CLOSED

Many technologically and societally important mathematical problems are intractable for conventional, serial computers. Therefore, a significant need exists for parallel-computing approaches that are capable to solve such problems within reasonable time frames. Recently, part of our consortium demonstrated proof-of-principle of a parallel-computation system in which a given combinatorial problem is encoded into a graphical, modular network that is embedded in a nanofabricated planar device. The problem is then solved by a large number of independent biological agents, namely molecular-motor-propelled protein filaments, exploring the network in a highly parallel fashion (PNAS 113, 2591 (2016)). Notably, this approach uses orders of magnitude less energy than conventional computers, thus addressing issues related to power-consumption and heat-dissipation. Within Bio4Comp we (i) will establish the technological and scientific basis for robust upscaling of this approach, (ii) will demonstrate scalability by systematically increasing the problem size by several orders of magnitude, and (iii) will develop new algorithms with the aim to open up a wide range of applications. Additionally, we will (iv) help foster and structure an ecosystem of scientists and companies that will accelerate the path to market acceptance, including the creation of a joint roadmap. Benefits to society will include the ability to solve hitherto intractable problems, and the development of a sustainable and energy-efficient computing approach that is radically different from current information and communications technology.

Keywords: parallel computing,alternate computing paradigm,molecular motors,biocomputation,nanotechnology,innovation ecosystem
The impact of neighbourhoods, peers and families on psychiatric disorders, substance use disorders and crime in first- and second-generation immigrants (MIGPACT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-03-31
Duration (months): 66.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The successful integration of the high numbers of refugees is one of the most critical issues facing the EU today. We propose to identify factors at the neighbourhood-, family-, peer-, and individual-levels that may protect immigrant children, adolescents and adults from psychiatric disorders, substance use disorders, and crime. We have access to highly accurate and almost complete nationwide sociodemographic data from 1960-2015 including, but not limited to, country of birth, education, income, employment, and social welfare, school grades, and reason for immigration linked to nationwide inpatient- and outpatient health care data, family relations, neighbourhood socioeconomic factors and indices of 250,000 neighbourhood goods and services. These timely data are available for more than 3 million 1st and 2nd generation immigrants, including over half a million more recent immigrants from the Middle East and Africa. We will apply different causal models and our novel designs (e.g., identification of deprived immigrant enclaves, deviant peer contexts, and natural experiments) to examine our aims. We are in a unique position to carry out the entire sequence of the proposed research from direct clinical observations, formulation of novel hypotheses and use of innovative analytic methods to interpretation of findings tailored to subgroups of immigrant populations. Findings from Sweden are highly relevant to the EU as around 25% of the entire population are 1st or 2nd generation immigrants. Our findings will delineate meaningful subgroups of immigrants, including refugees, similar to those in other EU countries. Based on our results, we will develop recommendations at the neighbourhood-, family-, peer-, and individual-levels that, when tailored appropriately, will help guide EU policies and strategies, thus leading to decreased strain on health and social services, improved psychiatric health and successful integration of immigrant populations.

Keywords: migration
Systematic Characterisation and Archiving of megafauNa on a regional scale in a Deep-sea area threatened by mining (SCAN-Deep)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-14
End date: 2020-03-13
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The worldwide demand for metals and rare-earth elements is increasing, fuelled by developing economies and the growth of high-technology green industries. The Clarion-Clipperton Zone (CCZ) in the tropical eastern Pacific Ocean contains vast reserves of polymetallic nodules on the abyssal seafloor, a future source of deep-sea minerals already targeted for exploitation. There is an almost complete absence of open biodiversity data on the large animals (megafauna) of this 6 million km2 area, and it is a pressing conservation priority to establish baseline data to enable future sustainable management of the region. In particular, a regional-level assessment that cuts across contracted areas is urgently needed to [1] establish the baseline quantitative ecology of the region, [2] assess species richness and ranges and thus, [3] enable the successful management of this globally important marine area in the context of a global ‘blue growth’ agenda. The objective of this fellowship is to develop the first regional-level approach to megafauna classification and identification in the CCZ. This will be done using a three-fold approach: (1) The development of a new open-access data-archiving bioinformatic pipeline for imagery and samples of megafauna from the entire CCZ, (2) the identification and characterization of megafaunal morphotypes observed across the CCZ regardless of exploration contract area and (3), development of biodiversity survey methods based on organismal DNA found in the environment (metabarcoding). This project will include knowledge transfers between the host and experienced researcher in the following areas: bioinformatics, digitisation, image analysis, megafauna taxonomy, DNA barcoding, metagenomics and transferable skills such as project management, scientific communication including science-policy interface work, laboratory health and safety, and career planning.

Keywords: deep sea mining,taxonomy,megafauna,archive,digitization,metagenomics,edna,image analysis,bioinformatics pipeline,clarion clipperton zone,pacific ocean
Responsible Research and Innovation in Practice (RRI-Practice)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Germany,Italy,Australia,India,Bulgaria,China,Norway,Norway,France,Netherlands,Netherlands,United States,Brazil,United Kingdom,United Kingdom
Call: Supporting structural change in research organisations to promote Responsible Research and Innovation (H2020-ISSI-2015-1, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 3635413.75
EU funding (EUR): 3635413.75
Participants: 16
Project status: CLOSED

The RRI-Practice project will bring together a unique group of international experts in RRI to understand the barriers and drivers to the successful implementation of RRI both in European and global contexts; to promote reflection on organisational structures and cultures of research conducting and research funding organisations; and to identify and support best practices to facilitate the uptake of RRI in organisations and research programmes. The project will review RRI related work in 22 research conducting and research funding organisations and will develop RRI Outlooks outlining RRI objectives, targets and indicators for each organisation. It will involve comparative analysis of the five EC keys of RRI locating these within broader, evolving discourses on RRI. Within each identified RRI dimension the project will analyse how the topic has developed in particular social and institutional contexts, how the RRI concept and configuration meshes, overlaps and challenges existing organisational practices and cultures, leading to an analysis of the barriers and drivers associated with operationalising and implementing RRI. 12 national case studies will allow for in depth studies of, and dialogue with, the included organisations, and will form the basis for systematic analysis and comparison of drivers, barriers and best practices on each dimension of RRI. The project design also allows analysis of such drivers, barriers and best practices related to national and organisational characteristics, safeguarding the need to take into account diversity and pluralism in regional RRI programs. These analyses will ultimately end up in recommendations to the EC about effective, efficient and targeted strategies for increasing RRI uptake in different kinds of organisations and national cultures, in Europe and in selected major S&T intensive economies worldwide. The project will also develop user-friendly guidance aimed directly at research and funding organisations themselves.

Keywords: organisational studies,best practices
Future Circular Collider Innovation Study (FCCIS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Austria,Germany,Italy,Italy,Switzerland,Poland,Russian Federation,France,France,Netherlands,United States,United Kingdom,Japan
Call: Design Studies (H2020-INFRADEV-2019-3, 2019)
Start date: 2020-11-02
End date: 2024-11-01
Duration (months): 48.0
Total project cost (EUR): 7455865.0
EU funding (EUR): 2999850.0
Participants: 19
Project status: SIGNED

What is the Origin of Everything? The Standard Model of Particle Physics explains everything except for the parts that it does not cover. This limitation calls for a science mission to gain a deeper understanding of matter, energy and the fundamental laws of nature. The first step is to elucidate the mysteries that revolve around the Higgs boson. Is it point like? Does it interact with itself? The best way to answer these such questions is to create a clean experimental environment with a highest luminosity particle collider. The Future Circular Collider Innovation Study (FCCIS) will deliver a conceptual design and an implementation plan for a new research infrastructure, consisting of a 100 km long, circular tunnel and a dozen surface sites. It will initially host an electron-positron particle collider. With an energy frontier hadron collider as a second step, it can serve a world-wide community through the end of the 21st century. This project will validate the key performance enablers at particle accelerators. Extreme luminosities, a factory producing a million Higgs bosons, luminosities up to 100 times the present world record with parts-per-million energy precision will strengthen Europe’s leadership in excellent science for many decades. This project will attract academic and industrial leaders to develop a feasible and affordable project that incorporates ecodesign and resource efficiency from an early stage onwards. The project includes work with the host states France and Switzerland to ensure that the infrastructure blends in with the territorial boundary conditions. A socio-economic impact analysis will reveal the added value that this infrastructure will generate during its first phase and serve as the basis for developing a funding and implementation plan. This project emphasizes the user capacity building process with theoretical and experimental physicists at an international scale to ensure an exploitation of the facility from the start.

Keywords: research infrastructure,particle physics,particle accelerators,international collaboration,socio economic impacts,eu smart specialisation,research and innovation missions,open innovation
TOwards Multi-stakehOldeRs transition ROadmaps With citizens at the centre (TOMORROW)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Romania,Serbia,Belgium,France,France,Netherlands
Call: Supporting public authorities to implement the Energy Union (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-09-01
End date: 2022-11-30
Duration (months): 39.0
Total project cost (EUR): 1499767.5
EU funding (EUR): 1499767.5
Participants: 10
Project status: CLOSED

By 2050, European cities should be decarbonised, sustainable and provide for a high quality of life. In order to achieve this goal, society as a whole has to become more accountable and mutual responsibility needs to be distributed amongst all actors. Therefore, urban governance schemes need to become more transparent and inclusive so that all can benefit. This is why public administrations need to be equipped with skills and support schemes. Local transition roadmaps draw on the required skills and capacities of local authorities and allow them to become leaders of the energy transition. Such roadmaps provide explicit strategies and operational tools for local governments to address the multiple challenges of the energy transition and their ecological, economic, and social aspects. Thereby, their development provides both, space for innovations to develop, and participatory approaches to flourish. TOMORROW aims at empowering local authorities to lead the transition towards low-carbon, resilient and more liveable cities by engaging citizens and stakeholders in the development of 2050 transition roadmaps. The development process of local transition roadmaps lies at the core of TOMORROW, which recognizes that the achievability of the formulated energy transition targets relies upon effective engagement of civil society, local key actors and their collaboration with local governments. For implementing deliberative governance schemes, the project´s pilot cities will be involved in city trainings and benefit from peer-to-peer activities with lighthouse cities. Best practices and innovative sustainable energy solutions, as well as innovative engagement mechanisms will be shared. Tailored support material, such as a toolbox containing methodological guidelines and factsheets on best practices will be developed for replication. Learning relays and masterclasses will improve participants´ capacities. Policy recommendations aim at an enabling framework for cities´ transition.

Keywords: energy transition,cities,roadmap,local authorities,citizen engagement,transition management,decarbonisation,energy union,stakeholder,innovative governance solution,deliberative democracy
Diversity innovation support scheme for SMEs (DINNOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Germany,Ireland,United Kingdom
Call: Supporting experimentation in innovation agencies (H2020-INNOSUP-2018-06-two-stage, 2018)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 696215.0
EU funding (EUR): 696215.0
Participants: 5
Project status: SIGNED

Due to changing demographics in Germany and the UK and associated retirement policies, in organisations age diversity is expected to increase. Previous research has suggested that age diversity can impact innovation on different organisational levels. On the individual level increased age is associated with a decline of fluid cognitive abilities, which are relevant for the development of innovative ideas. On the organisational level, conflicts, and age stereotypes have a negative impact on innovation. To prevent and even reverse the adverse impact of age diversity on innovation, an innovation support scheme for SMEs was developed and piloted in a previously conducted research project in Germany. This scheme included interventions for individuals and leaders. At the individual level, a cognitive ability training was introduced to reduce the decline of fluid cognitive abilities and in turn increase the generation of innovative ideas particularly for older employees. Moreover, a leadership training was introduced, which emphasizes on reducing age stereotypes and associated conflicts and enhance appreciation of age diversity. DINNOS, aims to conduct an evaluation of the effectiveness of this innovation support scheme in a sample of SMEs from Germany and the UK. In both countries, we will conduct a large scale randomized control trial involving an experimental- and a waiting-list control group with N=300 SMEs, and N=400 individual employees across both countries, which will be equally divided to both groups. On the individual level we will examine cognitive ability, individual creativity and innovation as outcomes. Whereas on the organisational level outcomes will consist of self-reported indicators, such as reduced age stereotypes and team innovation as well as objective outcomes such as number of submitted ideas and patents.

Keywords: age diversity,innovation in smes,individual cognitive ability training,leadership training
A paradigm shift in cancer therapy – using mitochondria-powered chemiluminescence to non-invasively treat inaccessible tumours (Lumiblast)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Norway,Greece,United Kingdom
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2016-10-01
End date: 2023-01-31
Duration (months): 76.0
Total project cost (EUR): 3031375.0
EU funding (EUR): 3031375.0
Participants: 5
Project status: SIGNED

Brain cancers such as glioblastoma multiforme (GBM) are practically incurable due to their location, invasiveness and highly aggressive nature. The use of light-based treatments of GBM by activating tumor-localized photosensitizers, such as in photodynamic therapy (PDT) has been clinically evaluated, but with limited success. This is mainly due to the limited penetration of light into tissue and the efficient spread of tumor cells typically up to at least 2 cm from the resection margin. Moreover, the existing photon based treatments (photodynamic therapy) are highly invasive and usually require open-cranium surgery, due to the need for external light sources. In the Lumiblast project the photons are produced inside the tumor cells in the form of chemiluminescence avoiding the major limitation of using external light to treat solid, deep-sited and inaccessible tumors. The principle utilized in Lumiblast may also be relevant for cancers of other origins. Due to its nature Lumiblast is expected to act on individual cells, rather than the collective lesion; it could thus completely eliminate the hitherto incurable GBM. Each GBM cell is expected to become a small lamp providing the light required for the photosensitive agents to become activated, killing the tumour cells from the inside. Lumiblast requires a concerted interdisciplinary action. The project coordinator (Berg’s group, Oslo University Hospital, OUS) is world renowned in PDT and photomedicine, while the team from the University of Athens (Georgios Vougioukalakis’ group, UoA) is up and coming with high expertise in synthetic chemistry. The Polytechnic University of Valencia (Miguel Miranda’s group, UPV) team is headed by a world leader in Photochemistry, the University of Oslo partner (Hanne H. Tønnensen’s group, UiO) is specialized in pharmaceutical formulation, and Knight Scientific Ltd (KSL, CEO Jan Knight) is an SME with an impressive track record in ROS-activated luminescence. This 4.5-year project will establish the Lumiblast breakthrough technology by providing proof-of-concept in extracellular systems, GBM cell cultures and animal models, with the vision to advance Lumiblast to the clinic 5-6 years after the end of the proposed project.

Keywords: photodynamic therapy,photomedicine,luminescence,experimental therapeutics mitochondrial medicine