Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Allosteric modulation of immune checkpoint complexes as a new mode of therapeutic intervention in immunotherapy (Allosteris)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 2499674.0
EU funding (EUR): 2499674.0
Participants: 1
Project status: SIGNED

The fastidious balance of our immune system to fight infections or cancer while avoiding autoimmune reactions is regulated by coinhibitory and co-stimulatory immune checkpoint complexes (ICCs), which have become major drug targets. We witness the skyrocketing progression in cancer immunotherapy with antibodies that block inhibitory ICCs whereas Abs that block stimulatory ICCs are in clinical trials for treating autoimmune diseases. Surprisingly, but likely fuelled by the most obvious focus on IC inhibitors, the field largely ignored that ICCs are genuine transmembrane receptors that transmit signals upon binding of an extracellular protein ligand. This leaves unexplored modes of therapeutic intervention that I will uncover by validating Nanobodies (Nbs) as first-in-class modulators of signaling pathways associated with immune receptors in a unique, previously unexplored fashion. By applying innovative immunization and bio-selection techniques and building on POC data, I will deliver Nbs for representative ICCs to demonstrate the efficacy and selectivity of these Nbs in preclinical models of various inflammatory conditions, focusing on cancer and autoimmune diseases. We will deliver novel therapeutics agents which may outperform current inhibitor-based immunotherapies that trigger a magnitude of side effects. In this regard, the Nbs will exert their therapeutic effect through a distinctive mode of action that will ensure patient safety, even in the event of an overdose.

Keywords: nanobody technology,immune checkpoint complexes
Enabling Environmental Mycotechnologies (EEM)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Belgium
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Enabling Environmental Mycotechnologies (EEM) EEM aims at developing soil fungal based remediation solutions to a commercial scale. Indeed, emerging fungal-based approaches have been proposed as attractive options for the biological treatment of polluted matrices, such as soil, sludge & sediments, and water. Such mycotechnological approaches also offer an exciting potential for the restoration of degraded ecosystems (mycoremediation and mycorestoration) as they have the potential to foster the adoption of low carbon, sustainable solutions in many industrial fields such as: agricultural biologicals (biostimulants, biopesticides, etc.), mycomaterials, production of enzymes for the industrial sector, products for the agri-food industry. The specific objectives of EEM are: •Securing NOVOBIOM’s core IP assets as one proprietary dynamic knowledge repository: this will be achieved by establishing a tailored fungal database for environmental applications •Setting NOVOBIOM’s strategic roadmap for the protection, diversification and scaling of all foreseen fungal applications.

Keywords: bioremediation
leveraging the energy transition by gamified learning and AI, guided by cross sectoral integrated services and digital twin models to foster accessible and human-centered energy saving experiences (ENERGENIUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Spain,Italy,Netherlands,Romania,Estonia,Germany,Greece,Serbia,Switzerland,Ukraine
Call: Digital tools for enhancing the uptake of digital services in the energy market (HORIZON-CL5-2023-D3-03, 2023)
Start date: 2024-09-01
End date: 2028-02-29
Duration (months): 42.0
Total project cost (EUR): 5214701.83
EU funding (EUR): 3999783.88
Participants: 18
Project status: SIGNED

The ENERGENIUS project provides an innovative pathway dedicated to cultivating an inclusive, community-driven energy transition, underpinned by the ethos of 'Leave No One Behind.' At its heart is the ENERGENIUS Suite, a comprehensive, one-stop-shop digital platform providing a wide range of interlinked services, including digital twin models, serious games, cross-sectoral dashboards, marketplace and AI-driven recommendations. This robust ecosystem amalgamates data across various sectors—from energy, healthcare, and finance to traffic, social media, real estate, and tourism—delivering customized, AI-powered solutions for energy efficiency. By harnessing the collective intelligence of its community, ENERGENIUS not only offers personalized energy-saving advice but also reciprocally enriches multiple sectors. Upholding the highest standards in interoperability and privacy-by-design, ENERGENIUS is establishing new milestones for secure, seamless cross-sectoral data exchange.
Histone-based biomarkers for lung cancer risk (PREVALUNG Hop On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Bulgaria
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 28.0
Total project cost (EUR): 494812.5
EU funding (EUR): 494812.5
Participants: 2
Project status: CLOSED

The addition of the widening partner Medical University Varna (MU-VARNA, Varna, Bulgaria) to the PREVALUNG EU project, will add a new dimension in terms of functional biomarkers, namely histone-based liquid biopsy, to the proposed methodologies regarding the understanding of the biology of chronic inflammation, cardiovascular risk and early lung cancer, to help define high-risk models. The final overall goal of the project is to propose personalized prophylactic interceptive measures. Histone complexes or nucleosomes, released from dying cells into the blood circulation, are found elevated in several types of cancers. Histones have a long half-life and are very stable in the blood. The proposed hop on partner masters an optimized and proprietary imaging flow cytometry approach, using a device called ImageStream. ImageStream is a multi-channel imaging technology that combines the multiplex properties of flow cytometry, and the visual power of microscopy to provide extensive information on a particle of interest. We previously showed that plasma circulating histones and histone complexes help diagnosing fatty liver disease in children and adult, as well as pediatric brain cancer. A panel of multiple histones (H2A, H2B, H3, H4, macroH2A1.1, macroH2A1.2, and their respective complexes) will be added to the already planned high dimensional omics-based program, to analyze biological correlates predicting high-risk and/or incidence of lung cancer in patients with cardiovascular diseases. Integration of multiple parameters will certainly prove valuable in increasing sensitivity, determining associations and prediction scores that may advance patient anti-cancer treatment decision-making. Furthermore, the newly identified histone signature may join the novel classifiers integrated in prediction software within PREVALUNG EU, and they will be patented by the consortium and proposed for licensing to a relevant biotechnology company.
Reliable Cause-Effect Quantification in Complex Dynamical Systems for Socially Beneficial Policies (DYNAMICAUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Tackling critical global challenges – climate change, personalized healthcare, or pandemic preparedness – demands robust quantification and understanding of 'if-then' relationships in complex spatio-temporal systems. Traditional dynamical models are limited by oversimplifications and computational constraints, while powerful hybrid models leveraging machine learning (ML) lack the interpretability and generalization capabilities essential for entrusting them with policy guidance. Filling this glaring research gap, DYNAMICAUS develops novel methods for reliable causal inference in such systems, overcoming existing limitations. I will establish a theoretical foundation for causal effects in hybrid dynamical models, develop robust uncertainty quantification techniques under unseen interventions augmented by active data acquisition to reduce uncertainty, and quantify the overall impact of steerable inputs on target outcomes. My methods will be validated across critical domains – climate modeling, treatment planning, and epidemic simulations – demonstrating universal applicability and profound potential for informing policy on pressing societal challenges. By integrating an ethicist directly into the research process from the outset, I proactively address societal implications, ensuring my methodological advancements are positioned to achieve positive social impact. With my unparalleled track record of leveraging machine learning expertise for social good by pushing the boundaries in scientific applications as well as my pioneering work on extending the scope of causal inference and hybrid dynamical systems modeling, this timely project is uniquely positioned to break new ground at the intersection of dynamical systems, causality, and socially beneficial machine learning.

Keywords: hybrid dynamical models,uncertainty,cause effect quantification,socially beneficial machine learning
Mining food for nutraceuticals for beneficial microbiome modulation (NUTROME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: CLOSED

The human gut microbiome is recognized as an essential element in human health and disruption of the homeostasis between the host and gut microbiome has been associated with the development of various diseases. Diet plays a major role in modulating the gut microbiome, but understanding the exact relationship and its effect on health remains a key challenge in microbiome research. NUTROME aims to develop nutraceuticals (food components with health benefits) based on key dietary components of the Mediterranean diet that are capable of modulating imbalances (or dysbiosis) on the human gut microbiome of two relevant population groups (the elderly, and people with irritable bowel syndrome). Understanding how key dietary components and gut microbiome interact in the context of dysbiosis will require insight of the taxonomic and functional composition and relevant ecological dynamics of the microbiome by cutting-edge microbiome manipulations and multi-omics approach. Joint analyses of metagenomics, metabolomics and metaproteomics data, together with measures of mechanistic experiments in in vitro (cells) and an in vivo (germ-free mice) model will allow me to provide a framework for the understanding of the potential molecular mechanisms behind these modulations. Other original aspects of NUTROME will be the evaluation of not only the impact of pure compounds, but also the development of new forms of presenting them (by encapsulation and/or immobilisation) to guarantee that they reach the target site and microbial population of interest in the gut. Collectively this will allow to design nutraceuticals for dietary intervention in the form of enriched foods or dietary supplements. NUTROME provides an exceptional opportunity to the researcher to gain state-of-the-art expertise in microbiomics along with other relevant research and transferable skills to strengthen her competitiveness for becoming an independent researcher.

Keywords: nutraceutical,human gut microbiome,modulation,key dietary components,multi omics,elderly,irritable bowel syndrome,dysbiosis,formulation,encapsulation,immobilisation,mediterranean diet
Dynamic Optical Ranging & Timing with Multipoint Measurement (DORT MuM)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

MUnique Tech`s DORT (Dynamic Optical Ranging & Timing) system is an optical pulsed device which offers a new high precise distance measurement. The system is designed for space applications which means, that space relevant distances can be absolutely measured with a very high resolution. Thanks to a high measurement rate fast movements can also be detected. The innovation of the technology is a novel mathematical algorithm which combines the best of state-of-the-art technologies like LIDAR and laser interferometer. The device will be used in very small satellites (CubeSats) and thus entre the NewSpace market. This technology is not only intended for space, but also enables a large number of applications in the terrestrial field, like Large Volume Metrology. MUnique Tech generates a very wide field of possibilities with a single system which can be seen as a game changing technology. During the project a multipoint measurement for the device will be developed. With an add-on to the existing measurement system, it is possible to measure several points in parallel with equal performance. This means an enormous competitive advantage in comparison to competing devices. The performance and versatility of the updated DORT technology will be proven in a measurement campaign with several partners. With the support of ‘Women TechEU’, the technological development of the system is boosted and the market validation starts. In addition, MUnique Tech will benefit from coaching, especially skills training like ‘how to grow a business’ and ‘negotiation strategies’, and networking on European level.

Keywords: laser ranging,space technology,new space,large volume metrology
Accelerating circular bio-based solutions integration in European rural areas (BioRural)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Coordination and support actions
Countries involved: Greece,Netherlands,France,Germany,Denmark,Poland,Lithuania,Latvia,Spain,Portugal,Italy,Slovenia,Romania,North Macedonia
Call: Mainstreaming inclusive small-scale bio-based solutions in European rural areas (HORIZON-CL6-2021-CIRCBIO-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 2999962.5
EU funding (EUR): 2999962.5
Participants: 19
Project status: SIGNED

The main objective of BioRural is to create a pan-European Rural Bioeconomy Network under which related stakeholders will cooperate to promote the currently available small-scale bio-based solutions in rural areas to increase the share of Bioeconomy, giving increased value in such remote areas. Such framework will contribute in bridging the gap between the available novel high-end bio-based solutions and the everyday European rural life by assessing the existing situation of European rural Bioeconomy, capturing grassroots-level needs and ideas, promoting effective exchange of knowledge and information and investigating the possible opportunities for regional development through the expansion of bio-based solutions integration in rural Europe. This way, BioRural will develop a transition framework towards a sustainable, regenerative, inclusive and just circular Bioeconomy across all Europe at local and regional scale and support innovators to scale-up inclusive and small-scale bio-based solutions in rural areas. To do so, the project will: (i) Assess and evaluate the current performance of the European rural Bioeconomy in the EU and identify factors affecting innovation adoption and diffusion of bio-based solutions in rural areas; (ii) Create four regional Rural Bioeconomy Platforms (RBPs) that will form a European Rural Bioeconomy Network (ERBN); (iii) Assess and promote success stories of bio-based solutions in rural areas; (iv) Develop and continuously optimise an online open stakeholders’ tool, named BioRural Toolkit; (v) Facilitate knowledge exchange and capacity building for the European rural Bioeconomy through a series of workshops in local, regional and European level; (vi) Create rural development blueprints for regional and business scale-up of resilient and circular bio-based solutions in rural areas and (vii) Disseminate and communicate all activities for maximum visibility and rural Bioeconomy expansion.

Keywords: agriculture and food,forestry and natural habitats,water aquatic systems,bioenergy,biomaterials
Remote Entanglement Between a Superconducting and a Spin Qubit (Superspin)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Netherlands,Finland,Czechia
Call: EIC Pathfinder Open (HORIZON-EIC-2025-PATHFINDEROPEN, 2025)
Start date: 2026-04-01
End date: 2029-03-31
Duration (months): 36.0
Total project cost (EUR): 2999137.5
EU funding (EUR): 2999137.5
Participants: 4
Project status: SIGNED

We are in the midst of a second quantum revolution based on controlling and manipulating of individual quantum states of atoms, ions, quantum dots or photons in microscopic systems. Quantum computers can solve complex problems exponentially faster than classical counterparts which is necessary to advance medicine, engineering, logistics, chemistry and other fields. Extremely secure communications and faster code breaking based on quantum innovations are essential for European technological sovereignty. Europe’s leading scientific position will rely on quantum computers, simulators and sensors, interconnected via quantum networks distributing information and quantum resources. However, the current state of quantum technology necessitates that many separate systems work independently of one another. The Superspin project's end goal is to establish the technology needed to optically link a superconducting quantum computer and a spin-based quantum memory, both of which function at very different frequencies. We need to convert signals from the microwave to the optics and the visible wavelength to the telecom regimes, and to do so we will be developing novel components operating at the single photon level. We will also create an optical quantum memory and a qubit chip based on superconducting technology that can communicate with such convertors. In Superspin, we will show that a quantum state from a superconducting qubit can be stored in a spin qubit, marking the first demonstration of this concept. With Superspin, we facilitate the scaling of quantum technology by allowing individual systems to interact with one another remotely, rather than relying solely on the construction of ever-larger isolated systems. By providing a primary building block for the interconnection of quantum processors, quantum memories, quantum sensors, and quantum repeaters over an optical network, our technological breakthrough creates new opportunities for European quantum technology platforms.

Keywords: quantum technologies,quantum optics,quantum information,hardware technology,quantum modem,quantum memory
Circadian Rhythms for Enhanced Cancer Therapy (TimeTeller)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

TimeTeller GmbH combines research knowledge on molecular interactions of the internal biological (circadian) clock with clock-controlled genes and their impact on the treatment of diseases. A five-fold increase in tolerability and a two-fold increase in efficacy can be achieved by administering the treatment at specific times of the day considering the patient’s circadian clock. TimeTeller GmbH is a spin-off of the Charité Universitätsmedizin Berlin, one of the largest university hospitals in Europe, and builds upon the work developed in the research group lead by Prof. Dr. Angela Relógio. With more than 3.7 million new cases and 1.9 million deaths each year, cancer is the leading cause of death and morbidity in Europe. Worldwide, 28 million new cancer cases each year are expected by 2040. About 60% of cancer patients must undergo chemotherapy – a nightmare for most patients, with life changing massive side effects and long-term health consequences. TimeTeller developed a saliva-based IVD for measuring the personal circadian rhythm (CR) to determine the optimal time for treatment administration for cancer patients and thereby reduce side effects and increase treatment effectiveness, eventually also preventing treatment dropouts. Two use cases are adressed: 1) Pharma services, for cancer drug development in the pharma industry to optimise treatment timing and hence reduce toxicity and enhance efficacy. 2) Clinical products, applied by/to individual patients to measure CRs and detect dysregulation (class B IVD) and to enable optimised treatment timing (class C IVD). Using TimeTeller will yield massive savings for pharmaceutical companies and in the health system. It will accelerate the development of treatments and drugs, shortening the time to market for improved and novel medications. The existing interest is exemplified by letters of intent (LOI) by pharmaceutical company Bayer and the Techniker Krankenkasse (TK), the largest health insurance in Germany.

Keywords: circadian rhythm,cancer,cancer therapy,ivd,companion diagnostic,complementary diagnostic