Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Up-scaled continuous production of artificial hair, fur and wool follicules using FUROID and HAROID technology (FUROID)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Czechia,Portugal,Netherlands
Call: Engineered Living Materials (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 4043375.0
EU funding (EUR): 4043375.0
Participants: 3
Project status: TERMINATED

The mission of FUROID is to enable animal-free production of hair (humans), fur (endangered animals) or wool (sheep). The key innovation is the development of continuous and scalable technology, enabling the end of using living animals as a source of fur and wool and dominating the market by 2030. Specifically, we will focus on the development of engineered living fur (ELF), The mission of FUROID is to enable animal-free production of hair (humans), fur (endangered animals) or wool (sheep). The key innovation is the development of continuous and scalable technology, enabling the end of using living animals as a source of fur and wool and dominating the market by 2030. The fundamental innovation will be reached by using a combination of nanostructured scaffolds (RESPILON), hair/wool/fur organoids (GENEUS), and automated biofabrication technologies (BIOFABICS). The ambition of the project is to make significant steps to development of HLM products will deliver set of unprecedent properties: • Animal free-production of fur (ELF) and wool (ELW) without environmental, biodiversity and ethical concerns. • Gene-encoded traceability system endangered species unnoticed, uncontrolled and unpunished endangered species poaching. • Novel vacuum-assisted 3D printing technology overcoming speed of SoA 3D bioprinters • Continuous manufacturing using an automated production system • DBTL platform for rational design and product optimization. • Living human hair follicles (ELH) for transplantation and treatment alopecia as medical and psychological problem. • Fur and wool textiles for apparel industry in rolls without size limitation delivering unprecedent properties. • Improved properties of engineered fur/wool textiles due to nanofiber membranes with regulated water permeability. The project will strengthen the portfolio of ELMs by developing scalable and generalizable technology for forming textured materials in roll-to-roll process from mammalian cells.

Keywords: fur,wool,hair,organoid,ipsc,genetic modification,animal welfare,cruelty free society,nanofibers,bioreactors,3d bioprinting
Exploring the pristine conditions for transforming interstellar dust into planetesimals (PEBBLES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France,Spain
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 2444587.5
EU funding (EUR): 2444587.5
Participants: 2
Project status: SIGNED

The formation and properties of exoplanetary systems is a fascinating question, which has been at the heart of our quest to define mankind and the conditions for life to develop in a broader context. Recent astronomical observations have deeply modified our paradigm of planet formation, as they suggest the so-called "proto-planetary” disks surrounding T-Tauri stars may actually already host planets. Moreover, we have obtained some of the first observational clues that the dust particles contained in the pristine disk-forming reservoirs that are the embedded protostars may already have significantly evolved from the submicronic dust populating the interstellar medium. These results suggest that dust evolves significantly already during the first 0.5 Myrs of the star formation process, and highlight the prime importance of understanding the properties and evolution of dust in young protostars. The PEBBLES project aims at developing a thorough methodology to characterize the properties of dust in embedded protostars, where we know the star and its disk are forming concomitantly. Using an innovative methodology combining cutting edge observational datasets, dust models and numerical models, we aim to transform our understanding of: 1) The nature of the dust incorporated in the youngest disks, a key for models of disk evolution towards planetary systems 2) The processes at work for dust evolution in young protostars, from envelopes to disk scales 3) The efficiency of magnetic fields to couple to the star/disk forming material, and set the disk properties By shedding light on early dust evolution, we will not only address one of the oldest and most challenging question regarding the initial conditions for planet formation in disks around solar-type stars, but also provide new insight to the conditions reigning and their impact on physical processes during the main accretion stage, during which stars acquire most of their properties.
Glocal ecosystems restoring soil values, roles and connectivity (SoilTribes)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Coordination and support actions
Countries involved: Portugal,Italy,Netherlands,Greece,Germany,Spain,Slovenia,Denmark,France,Romania,Poland
Call: Back to earth: bringing communities and citizens closer to soil (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 5999859.25
EU funding (EUR): 5999859.25
Participants: 27
Project status: SIGNED

SOILTRIBES main goal is to pave the way towards inspiring “back to Earth” narratives translated in new formats of knowing, feeling, and behaving in regard to soil, its importance and challenges, and its future, which is deeply connected with ours. Approximately 60-70% of EU soils are unhealthy and the soil degradation costs the EU several tens of billion euros per year. The EU Mission ‘A Soil Deal for Europe’ aims to invert this scenario having designed an ambitious plan where citizens and organisations are key. SOILTRIBES gathers 25 partners, from 11 countries from the different EU regions and designs a methodology that will contribute to the achievement of the ambitious EU plans by fostering soil literacy and connectivity, through the (i) establishment, activation, and empowerment of a multi-actor network (+1000 members), 7 Soil Lab Activators, 7 Stewardship Assemblies; (ii) financial and scale-up support scheme (+1,7M€ FSTP) to nearly 80 projects/ teams recognising existing solutions or the development of new innovative and creative solutions for an enhanced soil literacy; (iii) design of +10 resources, tools and manuals for long-term use by private/public organisations willing to engage with citizens to increase soil literacy; (iv) and program, curation and implementation of nearly 200 events for wide dissemination, communication and pollination of soil topics (workshops, soilathons, soilblitz, creative exhibition, festivals). Framed by an engaging narrative, the “Tribes” will share the same commitment and will embark on a powerful journey of transition and transformation, bolstered by the nexus of science, technology, arts, and society.

Keywords: soil,multi disciplinary,multi actor,multi language,multi setting,multi resources,creative and cultural sectors,soil experts,soil business and industry,science communication,sci tech arts
Single molecule reconstruction for high-throughput, short-read sequencing technologies (FuseSeq)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 162857.14
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Current advanced short-read sequencing technologies and third generation long-read sequencing technologies are still not capable of full molecule reconstruction in a high throughput manner due to their limited read length and throughput respectively. This project aims at bridging the gap between long reads and high throughput by developing a fragment labelling system compatible to high-throughput short-read Illumina sequencing technology. The labelling system consist of tags that can be incorporated into the target nucleic acid sequences using Tn5-transposase and can be subsequently used to create fragments from the target molecule, allowing the generated fragments to retain information of their original position in the target molecule, thus the reconstruction of the sequence of the original, individual target molecules from them. This technology has considerable market potential due to its relatively high ease of market entry as it can be incorporated in existing library preparation techniques for next generation sequencing since many of them readily use Tn5 transposase for fragment generation. Additionally, the ability to be able to link the short, high accuracy reads generated by high throughput next generation sequencing technologies can have a large interest in the field of genomics, by allowing the complete reconstruction of diploid human genomes by tackling more difficult, highly repetitive genomic segments, in the field metagenomics, by enabling the assembly of more complete genomes from clinical samples, and also in the field of transcriptomics, by providing information about isoform- and allelic-specific expression through the reconstruction of full length transcripts.
Unmasking Non-Genetic Determinants Instructing Tumor Initiation (IGNITE) (IGNITE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1995000.0
EU funding (EUR): 1995000.0
Participants: 1
Project status: SIGNED

The gene-environment interaction paradigm has long provided a framework for understanding the contribution of environmental cues to cancer initiation. However, recent perspectives reveal that even amongst genetically identical cells, responses to environmental variation can be remarkably diverse. When and how pathogenic gene-environment interactions effectively ignite cancer remains ambiguous. IGNITE aims to explain what drives cancer initiation beyond genetics by dissecting (mal)adaptive responses to environmental variation at the cell, tissue, and organismal level, taking inflammation-driven pancreatic cancer as a disease paradigm. I hypothesize that qualitatively distinct forms of local and systemic inflammation, which I refer to as “inflammatory contexts”, direct tumor evolution in ways that are largely predetermined by epigenetic fingerprints integrating cells’ lineage, mutational, and environmental exposure history. Hence, I will (1) identify epigenetic determinants underlying the differential potential of pre-malignant and malignant cell states to sense, communicate and evolve within distinct inflammatory contexts; (2) define tissue-level hallmarks of pathogenic vs homeostatic inflammatory contexts, and develop new approaches to engineer immune cell states distinguishing each; and (3) dissect poorly understood links between pancreatic cancer risk and distal inflammatory disorders to uncover organismal mechanisms. IGNITE’s multi-layered perspective of cancer susceptibility and evolution will integrate methodologies to map and functionally interrogate molecular, cellular, tissue, and systemic traits in human samples and physiological models to establish causal relations. In sum, IGNITE will unmask yet-unknown contextual determinants of cancer beyond genetic susceptibility. The project’s results, new methods and concepts will make it possible to rationally harness inflammatory cues for steering tumor evolution towards clinically manageable states.

Keywords: cancer initiation,pancreatic cancer,pre malignancy,immune responses,allergy,psoriasis,single cell sequencing,mouse models
Advanced 5G Open Platform for Large Scale Trials and Pilots across Europe (IMAGINE-B5G) (IMAGINE-B5G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Spain,Norway,Portugal,France,Greece,Finland,United Kingdom,Denmark,Ireland
Call: SNS Large Scale Trials and Pilots (LST&Ps) with Verticals (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2026-03-31
Duration (months): 39.0
Total project cost (EUR): 12388306.93
EU funding (EUR): 11011735.63
Participants: 19
Project status: SIGNED

The evolution of mobile telecoms networks Beyond-5G creates a tremendous opportunity for Europe to establish leadership in innovation by addressing the requirements of use case from PPDR, smart agriculture, media, eHealth, education, transportation, logistics, Industry 4.0, and energy sectors. IMAGINE-B5G project aims to create an advanced and accessible end-to-end (E2E) 5G platform for Large-Scale Trials and Pilots, providing a set of B5G applications, enabled by the integration of advanced 5G disrupting technologies. The project will support 3GPP Rel-17 and beyond features which are crucial for implementation of private networks under real-life operational conditions to enable advanced 5G services which are driven by the industrial needs and requirements of a wide variety of verticals. The functionalities built into the B5G platform will enable these advanced 5G vertical applications to be demonstrated at scale and will allow the project to identify and validate new 5G KPIs (Key Performance Indicators) and KVIs (Key Value Indicators) across three different but equally fundamental domains - societal, application and management. All KPIS and KVIs will be verified as relevant to the use cases supported, through demonstration of their importance to end-to-end large-scale trials and pilots. IMAGINE-B5G brings together four advanced 5G experimental facilities, in Norway, Spain, Portugal and France. These facilities will capitalise on previous 5G-PPP infrastructure (ICT-17) and vertical trial projects (ICT-19) reusing the platform components and extending the existing capabilities of these facilities. This will ensure a successful implementation of SNS-D-01-01 goals and expected outcomes. The IMAGINE-B5G strategy to achieve this is built up implementation of the latest 5G Rel-16 technology enablers. The project is envisioned to become an incubator, facilitating technology innovations and a diverse set of advanced 5G applications, services and ecosystem developments.

Keywords: trials,pilots,5g advanced,ppdr,media and entertainment,ehealth,education,transport and logistics,industry 4 0,kvis,kpis
Scaling up iPSC Expansion and Differentiation using Recombinant Bioemulsions (uPSCale)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Advances in stem cell technologies have revolutionised cell therapy and advanced in vitro models, but remain limited by our ability to scale up and automate cell manufacturing. In particular, induced pluripotent stem cell (iPSC) expansion and differentiation require complex processing protocols that are preventing the wider deployment of associated technologies to the clinic and industry. Although solid and hydrogel microcarriers have displayed potential in addressing this challenge, they present hurdles to the processing and separation from cell products, leading to contamination of the generated cells, the poor control of their phenotype and high production costs. Developing cost-effective, scalable, and regulatory-compliant platforms for culturing, differentiating and processing iPSCs, while circumventing reliance on solid substrates and microcarriers, remains critical for advancing cell manufacturing and will significantly impact the sustained growth of associated biotech markets. To mitigate contamination risks, streamline bioprocessing, and reduce associated costs, bioemulsions have emerged as promising alternatives. Despite their demonstrated performance in a growing range of cellular contexts, current underpinning protein and polymer nanosheet technologies raise concerns regarding regulatory compliance, for broad application in regenerative medicine. We propose the engineering of recombinant protein nanosheets for the stabilisation of biomedical grade oil microdroplets, that will tackle these challenges and allow the production of bioemulsions in a scalable format, aligned with regulatory expectations. The ability of the resulting bioemulsions to sustain the culture of iPSCs and their differentiation into defined lineages will be validated and this technology will be de-risked, in collaboration with industrial partners aiming to scale up iPSC technologies. This will allow the development of further IP that will support the exploitation of bioemulsions.
Sensory Emplacement on Trails: An Anthropological Study of Environmental Engagement in Outdoor Endurance Sports (TrailSense)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

As the climate crisis continues to escalate, engaging the public in meaningful conversations about climate change is more important than ever. To better understand how interactions with natural surroundings inform public participation and environmental engagement, TrailSense examines how participants in outdoor endurance sports—such as trail runners, hikers, and off-road cyclists—interact with their environments. Focused on emplacement and sensory experiences within outdoor endurance sports, TrailSense contributes to climate change discourses by examining and encouraging sustainable relationships with our natural environments. The project is designed to develop my methodological and leadership skills, employing sensory ethnography to examine the multisensory experiences of outdoor endurance participants within the Peak District National Park in the United Kingdom. Utilizing a combination of participant observation and sensation, go-along interviews, in-depth sit-down interviews, and visual anthropology using GoPro recordings and soundscapes, this project will provide rich, qualitative data on how individuals perceive and engage with their surroundings. TrailSense advances the concept of emplacement, emphasizing the importance of emplaced knowledges in promoting environmental sustainability, particularly in relation to trails. By examining the lived experiences of outdoor enthusiasts, the project will reveal the deeper connections people have with natural landscapes. In addition to its research focus, TrailSense embraces science communication and outreach by creating a multisensory installation in collaboration with the Peak District National Park and Trash Free Trails to effectively communicate the research process and its findings to the general public. In enhancing the dissemination of these emplaced knowledges, TrailSense foregrounds and fosters a deeper connection between people and environments, and promotes sustainable outdoor practices.

Keywords: anthropology of sport sensory studies climate change
TechCoach: Connecting Operational Groups across borders to enhance farmers’ ability to assess, adopt, and integrate Smart Crop Farming technologies (TECHCOACH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Netherlands,Greece,Italy,Finland,Hungary
Call: Broaden EIP Operational Group outcomes across borders by means of thematic networks to compile and share knowledge ready for practice (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 1898354.46
EU funding (EUR): 1851468.75
Participants: 8
Project status: SIGNED

Smart Crop Farming technologies allow farmers to optimize inputs and tailor cultivation practices to specific crop requirements. Despite the potential of these technologies to enhance agriculture, their adoption remains surprisingly low in Europe. Well-organized, farmer-focused, multi-actor advisory systems and networks can play a crucial role for farmers to understand and implement Smart Crop Farming technologies. These advisory systems involve multiple stakeholders and prioritize farmers' needs, while enabling knowledge exchange among diverse players. Operational Groups (OGs) provide a strong platform for this, but many lack the required capabilities. TechCoach's main objective is to strengthen farmers’ ability to assess, adopt, and integrate Smart Crop Farming technologies at the farm level, by facilitating collaborative innovation and multi-actor advisory in Operational Groups and AKIS. This will be achieved through the mobilization of OG’s and AKIS actors, as well as the utilization of existing and new thematic networks and Multi-Actor Approach projects, to gather and disseminate knowledge and experience for application in local contexts across Europe. TechCoach will serve a dual purpose: (1) strengthening the results of Operational Groups, and (2) accelerating these results through networks at the national and EU level. The approach includes 3 levels of interventions. Firstly, we learn how EIP Operational Groups facilitate their members in the adoption of Smart Farming technologies. Good practices are described, and gaps are identified. At the start of the project, TechCoach will work with 10 OG’s in 5 countries. Secondly, we connect project OGs, other OGs and AKIS actors in national networks to share knowledge and experience on the theme of facilitating Smart Crop Farming adoption and to narrow the identified gaps. And thirdly, we connect OGs and national networks across borders and enhance pan-European learning and collaboration in Smart Crop Farming.

Keywords: smart crop farming,capacity building,co innovation