Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Oxidised organic vapours in the atmosphere: From fluxes to chemical mechanisms and impacts (OXFLUX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 267793.2
EU funding (EUR): 267793.2
Participants: 2
Project status: TERMINATED

The oxidation of volatile organic compounds (VOC) in the atmosphere has crucial effects on aerosol particle formation, hence on the budget of cloud condensation nuclei, and thus on climate. The oxidation of certain biogenic VOC can quickly lead to highly oxygenated organics with very low volatility that have recently been found to play critical roles in all stages of aerosol formation. However, only a fraction of the underlying oxidation mechanisms is currently known, and open questions remain about how the full distribution of oxidation products interacts with the aerosol phase. Moreover, the problem of VOC oxidation is highly interdisciplinary, as it is subject not only to chemical reactions, but also to precursor emissions, natural climate feedbacks and anthropogenic perturbations, depositional losses, and mixing. The aim of OXFLUX is to reveal the formation mechanisms and subsequent fates of important VOC oxidation products, to better quantify their impacts on atmospheric chemistry, in particular on aerosol formation and growth, and ultimately on cloud formation and climate. The Experienced Researcher (ER) will address this challenge experimentally by combining novel mass spectrometric techniques, able to directly measure hundreds of VOC oxidation products, with flux measurements. Fluxes will be measured from towers in temperate and boreal forests, as well as from aircraft. These ambient measurements and their interpretation will be supported by laboratory studies and chemical transport modelling. During the return phase in Europe, the ER will establish continuous flux measurements of oxidised organics in a boreal forest in Finland, and collaborate with atmospheric modellers to include his findings in boundary layer simulations. The ambitious project’s host organisations are world leaders in the field of research and the involved experimental and analytical techniques, maximising the chances of the project’s success and its beneficial impact on the ER’s career.

Keywords: oxidation of biogenic volatile organic compounds,atmospheric mass spectrometry,new particle formation and growth,secondary organic aerosol
Cofactor Binding Antibodies – Basic Aspects and Therapeutic Innovations (CoBABATI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2023-02-28
Duration (months): 78.0
Total project cost (EUR): 1255000.0
EU funding (EUR): 1255000.0
Participants: 1
Project status: SIGNED

The immune repertoire of healthy individuals contains a fraction of antibodies (Abs) that are able to bind with high affinity various endogenous or exogenous low molecular weight compounds, including cofactors essential for the aerobic life, such as riboflavin, heme and ATP. Despite identification of cofactor-binding Abs as a constituent of normal immune repertoires, their fundamental characteristics and have not been systematically investigated. Thus, we do not know the origin, prevalence and physiopathological significance of cofactor-binding Abs. Moreover, the molecular mechanisms of interaction of cofactors with Abs are ill defined. Different proteins use cofactors to extend the chemistry intrinsic to the amino acid sequence of their polypeptide chain(s). Thus, one can speculate that the alliance of Abs with low molecular weight compounds results in the emergence of untypical properties of Abs and offers a strategy for designing a new generation of therapeutic Abs. Moreover, cofactor-binding Abs may be used for delivery of cytotoxic compounds to particular sites in the body, or for scavenging pro-inflammatory compounds. The principal goal of the present proposal is to gain a basic understanding on the fraction of cofactor-binding Abs in immune repertoires and to use this knowledge for the rational design of novel classes of therapeutic Abs. In this project, we will address the following questions: 1) understand the origin and prevalence of cofactor-binding Abs in immune repertoires; 2) characterize the molecular mechanisms of interaction of cofactors with Abs; 3) Understand the physiopathological roles of cofactor-binding Abs, and 4) use cofactor binding for the development of novel types of therapeutic Abs. A comprehensive understanding of various aspects of cofactor-binding Abs should lead to advances in fundamental understanding and in the development of innovative therapeutic and diagnostic tools.

Keywords: antibodies,cofactors,heme,riboflavin,therapeutic antibodies
invEstigation of pushing pRopeller engine Configurations trough wind tunneL Experiments (ERaCLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,Germany
Call: Aero-acoustic experimental characterization of a CROR (Contra Rotating Open Rotor) engine WT model with core flow in propellers architecture (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2018-07-01
End date: 2021-05-31
Duration (months): 35.0
Total project cost (EUR): 1313500.0
EU funding (EUR): 1025575.0
Participants: 4
Project status: CLOSED

ERaCLE will tackle the further developmet and eventual validation of a fast tool for the preliminary design of propeller based engine configurations from an acoustic point of view. This objective will be achieved throughout a WT test campaign to measure the near-field and far-field acoustic propagation of a pushing and wing mounted propeller-based propulsion, parameterized w.r.t. propeller design features, installation configurations, and different kind of aerodynamic flows generated by the wing through controlled boundary layers. WT test data will be collected, post-processed and exploited for further development and validation of a fast engineering toolset for the preliminary design of propeller-wing arrangements vs. acoustic performance. The design, manufacturing, assembling, and instrumentation of the WT model comprehensive of all the systems to perform the challenging research work are part of the Action.

Keywords: cror,wind tunnel,acoustics characterisation,aerodynamic characterisation
The role of epigenetic heterogeneity in cell fate decisions (EpiNoise)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2022-03-01
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

A fundamental question in biology is how different cell fates are generated. While it is clear that extensive remodelling of chromatin accessibility and DNA methylation is an essential step in early mammalian development, their roles in cell fate specification remain unclear. Furthermore, it is not known to what extent cell-to-cell differences in gene expression regulation affect cell fate decisions. The aim of this proposal is to uncover the roles of chromatin accessibility and DNAme in gene regulation and in cell fate specification during mouse development. I will use a novel sequencing approach for combined profiling of chromatin accessibility, DNA methylation and transcription in single cells as well as other state-of-the-art technologies to provide unique insights in the connection between chromatin accessibility, DNAme and transcription at the single cell level. Moreover, this proposal has the potential to drastically change our view of germ layer specification by highlighting the role of cellular heterogeneity in this process. Together, this will improve our understanding of both pluripotency and differentiation, advancing the fields of stem cell research and development. The proposed research combines my experience in the areas of cellular heterogeneity and multidisciplinary science with the host’s experience in single cell genomics, epigenetics and mouse development. The knowledge and skills gained from this project combined with my scientific and personal development will prepare me for my goal of establishing my own academic research group.

Keywords: dna methylation,chromatin accessibility,gene regulation,single cell genomics,mammalian development,cellular heterogeneity
Creating artificial turf yarns with new recycling technologies for circular economy (RE-MATCH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The market of artificial turf (AT) has been gradually increasing over the last years, with a production expected to reach 487,4 ktons by 2021, with a similar trend for the amount of end-of-life turf being generated. Approx. 50 million m2 of sport turf were disposed worldwide in 2017, and this is expected to increase by >70% in 2021. Nevertheless, there is still no sustainable solution for the treatment and disposal of every AT component. with the combination of two technologies, Re-Match has developed an innovative process that fills this gap, by efficiently separating components and converting clean plastic fibres into a resin usable for production of high-quality turf yarns. This game changing novelty enables the upcycle of all the components, providing 100% circular life-cycle of ATs. It is a cradle-to-cradle solution that contributes to the emergence of circular economy models, that will decrease the environmental footprint and greatly reduce the waste being disposed. Re-Match forecasts to sell around 27,000 ton after five years of market introduction, reaching a revenue of more than €32M, in year 5, with a market share of approx. 25% in Europe. To make this a reality, Re-Match needs firstly to define and optimize a pilot plant for resin production, and to overcome some barriers such as user acceptance. This can be achieved through large trial-fields demonstrations, for which Re-Match already established partnerships with very relevant players (football associations and municipalities) to succeed in the project implementation and exploit the opportunity of this groundbreaking innovation.

Keywords: artificial turf,circular economy,recycling
“Establishing services enhancing the innovation management capacity of SME's in the Enterprise Europe Network” in Flanders (VEBIN SME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Belgium
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 52500.0
EU funding (EUR): 42000.0
Participants: 1
Project status: CLOSED

This project proposal aims at establishing the new services of EEN in Flanders with regard to the key account management for the SME instrument under H2020 as entrusted by the European Commission to the Enterprise Europe network. It also concerns the additional support services that EEN will deliver with regard to the enhancement of the innovation management capacities of SMEs as decided the H2020. The present proposal describes how the Flemish VEBIN consortium will establish the new services in the region of Flanders, how these will be embedded in the regional innovation support system to the benefit of Flemish SMEs, how the consortium will manage the services and how feedback will be organised in order to ensure a high quality service provision and an added European value. It particularly reflects on the signposting of clients among all relevant support stakeholders and to the efficient use of existing tools. It also expresses the consortium willingness to cooperate whenever requested by the Commission or by EASME to participate in benchmarking exercises among the various participating consortia and to give feedback on the implementation of these new services in the region of Flanders (Belgium).

Keywords: innovation management capacity enhancement,key account management sme instrument
A Hybrid Reactor for Solar CO2 and N2 Conversion Coupled to WasteWater Treatment (HYSOLCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Belgium,Luxembourg,United Kingdom
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 2767532.5
EU funding (EUR): 2762532.5
Participants: 7
Project status: SIGNED

The proposal focuses on the successful development of a new concept of low-cost flow photo-reactor prototype for the reduction of CO2 and N2 to produce fuels and chemicals (CH4, C2H4, C3H6 and NH3) coupled to the oxidation of microplastics and organic pollutants from wastewater treatment plants. To achieve this ground-breaking goal, an interdisciplinary consortium has been gathered that tackles the multiple involved challenges in a holistic manner: (i) Design and synthesis of highly efficient and stable photocathodes for CO2 and N2 reduction (ii) Development of low-cost and long-duration anodes for the electro-oxidation of microplastics and other organic pollutants in wastewater (iii) Design and fabrication of cost-effective, selective and photo-stable ion-exchange membranes (iv) Advanced characterisation of materials at different levels with state-of-the-art spectroscopic techniques (v) Integration of developed CO2/N2 reduction photocathodes, waste/microplastic oxidation anodes and ion-exchange membranes in a solar-powered flow reactor for simultaneous water detoxification and CO2/N2 valorisation (vi) Validation of the prototype in a wastewater treatment plant and (vii) study of the developed materials and devices from an environmental, economic and social point of view. In this ambitious work plan, the fundamentals of photocathodes, anodes and membranes will be revisited with a totally new insight based on the previous experience of the partners in other disciplines such as catalysis, materials science, batteries and water treatment. The likelihood for success of this high risk / high gain approach is supported by the strength of the consortium, with first-row researchers in the different joined disciplines with high complementarities and synergies. The presence of 3 SMEs with experience in managing and exploiting R&D results ensures the full exploitation of the potentially market-transferable results of the project.
Innovative mixed-anion approach to design materials with optical and selective ionic conduction properties (MixedAnionDEMO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Because the Earth’s atmosphere contains mainly reactive oxygen (and inert nitrogen), conventional inorganic synthetic materials are mostly oxides. From the research point of view, the 20th century was a prosperous era in the field of solid-state chemistry with discoveries of many inorganic oxide compounds that laid strong foundations of materials synthesis and characterization. The impressive development of oxides followed by other single-anion compounds, such as fluorides, nitrides, and chlorides is mainly due to their stability and ease of synthesis. Nevertheless, after a century of intensive research both conventional solid-state techniques and numerous combinations of metals (or cations) are reaching a point where they have been exhausted, which makes further development of new single-anion inorganic materials more and more difficult. Consequently, today, compounds with multiple anions beyond the single-oxide ion composition, offer a new playground for materials development where greater functionality can be found. Besides, unlike oxides, which exhibit chemistry and structures often known from mineralogy, the structures of most mixed-anion compounds are yet less explored with much more to learn. The aim of this project it to show how the mixed-anion approach will be beneficial to many fields of solid-state chemistry and how the candidate and the host researcher will apply it to the topics tackled by the host group: materials with optical properties and selective ionic conductivity. On the one hand, the candidate experience in oxide-derived materials and on the other hand, the host researcher expertise in the fluorine-derived materials will allow a broad prospection of new compounds and consequently functional materials with new properties. Finally, the combined efforts of the candidate and the host researcher is to expand the whole group topic from "chemistry and photonic of oxide and fluoride materials" to "chemistry and photonic of mixed-anion materials".

Keywords: solid state chemistry,mixed anion materials,oxides,fluorides,band gap,ionic conductivity
Three-photon fluorescence imaging deep inside scattering media (DEEP3P)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Investigating the complex structure and functioning of biological systems through light microscopy represents a foundational pillar of the life sciences. However, the very complexity of the samples cellular structure leads to one of the main limitations of optical microscopy: light scattering confines it to the outer most tissue layers. In the past decades, multiphoton microscopy successfully extended the accessible depth ranges and on a different front, advances in optical wavefront shaping showed that scattering can be compensated for, even in regimes where light fully lost its initial directionality. The aim of this action is to establish scattering correction through wavefront shaping in higher-order multiphoton microscopy, namely three-photon fluorescence imaging, to surpass the scattering barrier and reach unprecedented depths in optical microscopy.

Keywords: light in complex media,wavefront shaping,multiphoton microscopy,three photon fluorescence,adaptive optics
Bioenergy Villages (BioVill) - Increasing the Market Uptake of Sustainable Bioenergy (BioVill)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Germany,Serbia,Romania,Croatia,Slovenia
Call: Market uptake of existing and emerging sustainable bioenergy (H2020-LCE-2015-3, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1998917.5
EU funding (EUR): 1998917.5
Participants: 9
Project status: CLOSED

The overall objective of BioVill is to develop regional bioenergy concepts in Slovenia, Serbia, Croatia, Macedonia and Romania up to the investment stage in order to become “bioenergy villages”. This will increase the market uptake of bioenergy on the basis of cooperation with partners from countries with established bioenergy markets (Austria, Germany). The following specific objectives and activities will contribute to the overall objective: (1) 5 villages have developed the institutional set-up and energy management concept for becoming a bioenergy village up to investment stage for physical infrastructure with at least one bioenergy village in Serbia, Croatia, Slovenia, Romania and Macedonia. The local market uptake of bioenergy value chains are to be proven by signing of letters of commitment. (2) Mobilization of 62 GWh/y heat and power based on solid biomass in at least 5 target villages. The individual biomass value chains will include the production and distribution of heat and electricity. The concepts include technical and non-technical aspects for each target village. (3) Increase public acceptance of sustainable bioenergy and raise public awareness on commercial opportunities for farmers, foresters and the bioenergy value chain as a whole by means of public participation. This will be realized by ensuring the public participation of the inhabitants (5,000 households) in the target regions for setting up at least 5 villages across the 5 implementing countries. (4) Capacity Building of users and key actors in business and legislation to manage the bioenergy villages in a sustainable way and be able to either enact the EU based national legislation or make full use of the opportunities that these new markets create for them. In the set-up of bioenergy villages along the bioenergy value chains it will involve at least 500 participants in order to have a critical mass of key actors.

Keywords: bioenergy villages,market uptake,heat and power,public acceptance,capacity building