Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Green Epile: Development and implementation of a new generation of energy piles (GREEN EPILE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: France
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The buildings sector represents 40% of the European Union’s (EU) total energy consumption, with heating/cooling systems accounting for up to 68%. The major part of this demand is still covered using fossil fuels and CO2 emissions from this sector represents 36% of the EU’s total. Reducing energy consumption and increasing energy efficiency in buildings is today a prime objective according to the new EU directives. In line with these new regulations, shallow geothermal applications for heating/cooling of buildings have experimented lastly an expansion. The global geothermal heat pumps market revenue in 2013 was €49 billion and is estimated to reach €115.4 billion by the end of 2020, with a progressive CAGR of 13.1%. Europe accounts for almost 50% of this market. Pinto, a French company with more than 40 years of experience in the field of special foundations, has developed the Green Epile project on energy piles. Energy piles are an integration of heat exchanger pipes with structural foundations. They are a double purpose structure, as they are used simultaneously to withstand the construction load and to obtain thermal heat from the underground. Our working prototype has already covered 100% of the heating/cooling needs during the test period, supplying around 22000kWh/year. With the Green Epile project we plan on one hand to reduce the current design & installation costs by 30% and on the other to increase the guaranteed exploitation period up to 25 years. Boreholes, which are currently the competitive solution in the market, require a higher initial investment and need place for the installation, while energy piles remain invisible in the foundations of the building. We will start introducing our technology in the national market because it is one of the strongest ones in Europe: it represents the 25% with €238 Million in 2008. We will also target emergent markets (like Romania or Bulgaria) which will suppose the internationalisation of our company.

Keywords: energy,pile foundations,geothermal,energy efficient,buildings,net zero,affordable heating
Breaking the temperature limits of Solid Oxide Fuel Cells: Towards a new family of ultra-thin portable power sources (ULTRA-SOFC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-04-01
End date: 2021-03-31
Duration (months): 60.0
Total project cost (EUR): 1841387.0
EU funding (EUR): 1841387.0
Participants: 1
Project status: CLOSED

Solid Oxide Fuel Cells (SOFCs) are one of the most efficient and fuel flexible power generators. However, a great limitation on their applicability arises from temperature restrictions. Operation approaching room temperature (RT) is forbidden by the limited performance of known electrolytes and cathodes while typical high temperatures (HT) avoid their implementation in portable applications where quick start ups with low energy consumption are required. The ULTRASOFC project aims breaking these historical limits by taking advantage of the tremendous opportunities arising from novel fields in the domain of the nanoscale (nanoionics or nano photochemistry) and recent advances in the marriage between micro and nanotechnologies. From the required interdisciplinary approach, the ULTRASOFC project addresses materials challenges to (i) reduce the operation to RT and (ii) technological gaps to develop ultra-low-thermal mass structures able to reach high T with extremely low consumption and immediate start up. A unique μSOFC technology fully integrated in ultrathin silicon will be developed to allow operation with hydrogen at room temperature and based on hydrocarbons at high temperature. Stacking these μSOFCs will bring a new family of ultrathin power sources able to provide 100 mW at RT and 5W at high T in a size of a one-cent coin. A stand-alone device fuelled with methane at HT will be fabricated in the size of a dice. Apart from breaking the state-of-the-art of power portable generation, the ULTRASOFC project will cover the gap of knowledge existing for the migration of high T electrochemical devices to room temperature and MEMS to high T. Therefore, one should expect that ULTRASOFC will open up new horizons and opportunities for research in adjacent fields like electrochemical transducers or chemical sensors. Furthermore, new technological perspectives of integration of unconventional materials will allow exploring unknown devices and practical applications.

Keywords: microsofc,nanoionics,nano photochemistry,micro power generation,low t electrochemical,devices
Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement (MOBILISE-D)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Ireland,Italy,Italy,Italy,Germany,Germany,Germany,Israel,Germany,Spain,Germany,Switzerland,Switzerland,Norway,Belgium,Switzerland,Belgium,Sweden,France,France,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Linking digital assessment of mobility to clinical endpoints to support regulatory acceptance and clinical practice (H2020-JTI-IMI2-2017-13-two-stage, 2017)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 49911564.15
EU funding (EUR): 25395897.0
Participants: 38
Project status: SIGNED

Optimal treatment of the impaired mobility resulting from ageing and chronic disease is one of the 21st century's greatest challenges facing patients, society, governments, healthcare services, and science. New interventions are a key focus. However, to accelerate their development, we need better ways to detect and measure mobility loss. Digital technology, including body worn sensors, has the potential to revolutionise mobility assessment. The overarching objectives of MOBILISE-D are threefold: to deliver a valid solution (consisting of sensor, algorithms, data analytics, outcomes) for real-world digital mobility assessment; to validate digital outcomes in predicting clinical outcome in chronic obstructive pulmonary disease, Parkinson’s disease, multiple sclerosis, proximal femoral fracture recovery and congestive heart failure; and, to obtain key regulatory and health stakeholder approval for digital mobility assessment. The objectives address the call directly by linking digital assessment of mobility to clinical endpoints to support regulatory acceptance and clinical practice. MOBILISE-D consists of 35 partners from 13 countries with long, successful collaboration, combining the requisite expertise to address the technical and clinical challenges. To achieve the objectives, partners will jointly develop and implement a digital mobility assessment solution to demonstrate that real-world digital mobility outcomes can successfully predict relevant clinical outcomes and provide a better, safer and quicker way to arrive at the development of innovative medicines. MOBILISE-D's results will directly facilitate drug development, and establish the roadmap for clinical implementation of new, complementary tools to identify, stratify and monitor disability, so enabling widespread, cost-effective access to optimal clinical mobility management through personalised healthcare.

Keywords: digital mobility assessment,ageing,digital outcomes,copd,hip fracture recovery,clinical cohorts
Triggering Haematological Adoptive T-cell Immunotherapy Strategies by HUnting Novel T-cell receptors (THAT IS HUNT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Recent encouraging clinical results obtained with engineered T lymphocytes and increasing advances in the genome editing field, have opened new opportunities for T-cell receptor (TCR) gene therapy as an immunotherapeutic approach for cancer. Unfortunately, the broad applicability of this treatment is still hampered by the possible mispairing of exogenous/endogenous TCR chains and by the limited number of high avidity tumor-specific TCRs. While the first issue has been successfully addressed by the hosting lab with the development a TCR gene editing protocol, the identification of novel tumor-specific TCRs is urgently required and this is the aim of my research proposal. We have the unique opportunity to combine the highly complementary expertise of the hosting lab in T-cell biology/genetic transfer and of the applicant on immune repertoire sequencing. We will target acute myeloid leukemia (AML) and hypothesize that by exploiting intrinsic features of AML (i.e. ability of AML blasts to differentiate into potent antigen presenting cells expressing tumor antigens), the functional fingerprint induced by AML on tumor-reactive T-cells, and cutting-edge technologies (i.e. next generation sequencing; ligandome landscape analysis), we will provide a comprehensive immunoprofiling of tumor-specific T-cells and isolate tumor TCR specificities. Results obtained in this study will streamline TCR hunting studies in solid tumors, leading to the generation of a TCR library for different antigens and HLA restrictions, thus rendering TCR gene editing an innovative off-the-shelf treatment available for a high number of cancer patients. Awarding this fellowship will greatly enhance researcher’s career not only by providing the opportunity to widen scientific knowhow and acquire new skills, but also by enabling the researcher to address a major bottleneck currently limiting the full exploitation of the rapidly growing field of cancer immunotherapy.

Keywords: t cells,immunotherapy,tumor antigen
Global Earth Monitor (GEM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Spain,Belgium,Switzerland,Slovenia,Netherlands
Call: Big data technologies and Artificial Intelligence for Copernicus (H2020-SPACE-2020, 2020)
Start date: 2020-11-01
End date: 2023-08-31
Duration (months): 34.0
Total project cost (EUR): 3504062.5
EU funding (EUR): 3504062.0
Participants: 7
Project status: SIGNED

Global Earth Monitor project (GEM) is addressing the challenge of continuous monitoring of large areas in a sustainable cost effective way. The goal of the project is to establish a new disruptive Earth Observation (EO) DATA-EXPLOITATION MODEL which will dramatically enhance the exploitation of Copernicus data. For the first time a continuous monitoring of the planet on the global/regional scale will be enabled for a sustainable price. Disruptive innovations are planned in the technology and in the methodology domain, where a proprietary concept of Adjustable Data Cubes (a combination of static and dynamic data cubes) will be developed and integrated with EO-oriented open source Machine Learning (ML) framework EO-LEARN. During the project EO-LEARN will be upgraded to consume ML technologies from widely accepted ML frameworks and to adapt/evolve them to specifics of EO-data interpretation. Modern ML technologies and approaches (GAN, RNN, LSTM, Attention & Bayesian Deep Learning, Curriculum Learning, Incremental learning, Meta-learning, Hybrid modelling) will be combined to construct GLOBAL, SCALE-INDEPENDENT interpretation models with the special focus on CAUSALITY and CHANGE DETECTION. Technological and Methodological innovations will be combined into a unique CONTINUOUS MONITORING PROCESS. The process, based on seamless combination of data interpreted with sub-resolution, native resolution and super-resolution methods, will deliver optimal combination of Processing/Storage costs – enabling continuous monitoring of large areas for just a FRACTION OF CURRENT COSTS. The concept of continuous monitoring will be validated through the development of five specific use-cases and through their employment in a 10-month demonstration - operational continuous monitoring of 10 MIO square km area.

Keywords: continuous global earth monitoring,change detection,causality
Polifonia: a digital harmoniser for musical heritage knowledge (Polifonia)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Italy,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Curation of digital assets and advanced digitisation (H2020-SC6-TRANSFORMATIONS-2020, 2020)
Start date: 2021-01-01
End date: 2024-04-30
Duration (months): 40.0
Total project cost (EUR): 3046154.26
EU funding (EUR): 3025435.06
Participants: 11
Project status: SIGNED

Polifonia implements a digital ecosystem for European Musical Heritage: music objects along with relevant related knowledge about their cultural and historical context, expressed in different languages and styles, and across centuries. The ecosystem will include methods, tools, guidelines, experiences, and creative designs, openly shared according to F.A.I.R. principles. The aim is to provoke a paradigm shift in musical heritage preservation, management, studying, interaction, and exploitation. Ten pilots, spanning from historical bells and organ heritage, classification of polyphonic notated music, to the historical role of music in children's lives, will drive the development of the ecosystem through continuous validation of its technologies. The Web, its standard formats and protocols are used as its reference architecture. Knowledge graphs are the enabling technology for integrating, representing, and interlinking music-related data with heterogeneous and distributed provenance. Dedicated research in Semantic Web, Data Science, Machine Learning, Language Technologies, and Human-Machine Interaction will enable discovery and automatic analysis of massive data, as well as their reuse for research, consumption and promotion. The project is conceived by an interdisciplinary team of passionate researchers and curators: computer scientists, anthropologists and ethnomusicologists, historians of music, linguists, musical heritage archivists, cataloguers and administrators, and creative professionals. They bring real-world use cases to define the ten pilots. The planned dissemination and exploitation actions allow the creation of a stakeholder network since the early stage of the project. Specific initiatives address societal and economic challenges: increased accessibility to musical heritage for people with disabilities; reproducible and sustainable creative designs for promoting musical heritage; increased engagement of young female students in STEM curricula.

Keywords: music,musical heritage,cultural heritage,digital heritage,knowledge graphs,human machine interaction,semantic web,data science,machine learning,artificial intelligence
Urinary bladder bioprinting for fully autologous transplantation (UroPrint)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Greece,Greece,Netherlands,Portugal,Portugal
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 3058434.99
EU funding (EUR): 3058434.99
Participants: 7
Project status: SIGNED

A number of conditions, including trauma, inflammation, incontinence, overactive bladder, renal impairments, neurological disorders (like spinal cord injury or spina bifida) and cancer, require bladder augmentation. For almost a century now, the majority of cystoplasties utilize bowel segments (enterocystoplasty). This, almost a century years old, gold standard practice bears numerous risks and complications affecting the majority of patients, thus compromising the quality of life while burdening the health care systems. This has fuelled efforts towards the development of engineered bladder tissue. Advancements in bioprinting technologies are increasingly employed in regenerative medicine but mostly in smaller and less complicated tissues. UroPrint proposes the use of Laser Induced Forward Transfer (LIFT) to generate bladder tissue for autologous transplantation that would meet the biological, mechanical and functional properties of human bladder. To this end, primary urothelial and smooth muscle cells will be obtained from healthy donors and expanded in fully Good Medical Practice compliant methodologies. These will be combined with novel natural autologous scaffold material obtained from platelet lysates. Then, a novel approach in the generation of bladder transplant will be utilized, combining intestine denudation and in vivo printing during surgery using a novel prototype LIFT printer that achieved high spatial resolution (<10 μm), high cell viability (>95%) single-urothelial cells.

Keywords: urinary bladder engineering,autologous biometarials,laser induced,forward transfer of cells,laser bioprinting,in vivo laser bioprinting
Microfossils and data science: a new approach to infer the impact of global climate on plankton Macroecology (MICRO2MACRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

One of the most pressing scientific challenges today is understanding the fate of our oceans and marine ecosystems under on-going climate change. Unfortunately, anthropogenic stressors act at a rate and magnitude that exceed recent natural variability, making the use of decadal ecological data and time-series insufficient for predictions of future behaviour of marine ecosystems. MICRO2MACRO will reconstruct snapshots of marine pelagic ecosystems between 54 and 32 million years ago (Eocene and early Oligocene), when climate and environmental conditions approximated what we will start to experience in the next century and beyond. Using the microfossil record of planktonic foraminifera (PF), the most complete of any Cenozoic eukaryote, the project will generate the first methodologically controlled (hence reproducible) early Cenozoic global dataset of ecology, abundance, species composition, diversity and biogeography (macroecology) of these prolific pelagic calcifiers. Benefiting from the mole of data generated over the last 15 years, I will learn and apply novel tools in data-science technology to compile ocean temperature and chemistry datasets for the studied time intervals and statistically compare them against the new PF dataset generated with this project. This study will combine the most advanced knowledge in several disciplines (micropaleontology, informatics, statistical ecology) to test for links between time-specific climate (e.g., sea surface temperatures) and ecosystem (e.g., species composition, dominant ecology) configurations, and understand how plankton biogeography was shaped in a warmer world. Hence, MICRO2MACRO will highlight future ecological and evolutionary analogues if the current climate trajectory remains interrupted and we are to hit climate conditions similar to those in the Eocene and Oligocene. Given the uncertainties associated with projections based on modern data this study will represent a major advancement in the field.

Keywords: microfossils,foraminifera,climate change,paleogene
all-in-one machine for hybrid technologies enabling high value added multi-scale integrated micro.optoelectronics (Mesomorph)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Switzerland,Switzerland,Lithuania,Denmark
Call: Assembly of micro parts (RIA) (H2020-NMBP-TR-IND-2020-singlestage, 2020)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 9867708.63
EU funding (EUR): 9867707.5
Participants: 13
Project status: SIGNED

The new emerging generation of microsystems represents a major opportunity for a substantial EU economic growth, in an industry counting already more than 200.000 workers and a turnover in 2019 of €450 billion. The Mesomorph concept provides the means to overcome the following 4 main hurdles: 1. The intrinsic physic of microsystems doesn’t allow the simple downsizing of conventional technologies to industrialize micromanufacturing processes. Mesomorphallows to limit the number of micromanipulation tasks by integrating an all-in-onemachine featuring novel processes for the direct creation of functions (electronic, fluidic, optic) directly on a substrate, with a RESOLUTION down to 300nm, by combining multi-material addition (Two-Photon Polymerization, Atomic Layer 3D nano printing) and subtraction (Femtolaser micro-ablation) in a self-contained white room. 2. Because of the intrinsic slowness of physical processes at microscale, productivity cannot be achieved by sequencing multiple single steps. Mesomorph proposes a scaleup throughput by PARALLELIZATION and batch processing UP TO 50k PARTS/YEAR, leveraging a new multiple micronozzles system to extend the SADALP working area from 10x10mm up to 500x500mm, and concurrently leveraging on the beam splitting technique of a high-power fs laser for ablation. 3. Microsystems cannot be conceived with subcomponents. Mesomorph includes a specific Design-to-Lifevalue Platform to guide the development of new microsystems by fully exploiting the new processes. 4. Innovation cannot be limited by the financial risk associated with the necessary investments. Mesomorph implements a new “Manufacturing as a Service” business model in which all the value chain’s actors can benefit from a positive net cash flow since production's start, effectively removing entry barriers for innovators. Mesomorph consortium is composed of 13 partners from 5 different countries. Each partner represents excellence in its own field.

Keywords: all in one machine,two photon polymerization,femtolaser ablation,atomic layer 3d nanoprinting,micro optoelectronics,muicrosystems