Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
TACK Superphylum and Lokiarchaeota Evolution: Dissecting the Ecology and Evolution of Archaea to Elucidate the Prokaryote to Eukaryote Transition (TACKLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-08-01
End date: 2022-07-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The emergence of complex eukaryotic life forms on Earth from prokaryotic cells is one of the most fundamental questions in biology and also one of the least understood transitions in evolution. Phylogenomic studies recently indicated that the eukaryotic line of descent arose from within the TACK+L superphylum of Archaea. This proposal addresses the systematic analysis of two newly discovered, but largely uncharacterized lineages of Archaea from this superphylum that mark crucial evolutionary transitions. Thaumarchaeota harbor unique ‘eukaryotic’ features and represent the sole group of Archaea that has successfully radiated into virtually any moderate habitat on Earth. The Lokiarchaeota lineage found recently in deep marine sediments forms a direct sister group of Eukaryotes and exhibits an unprecedented array of genes that might have been instrumental for the ancestor of eukaryotes to develop its cellular and genomic complexity. Obviously, the molecular and biochemical investigation of both groups is timely and important, yet, it requires easy access and cultivation. We have now discovered Lokiarchaeota in local, accessible environments and were able to successfully cultivate thermophilic Thaumarchaeota. In this proposal, we will characterize the metabolic and structural traits of these two archaeal lineages and reconstruct their evolutionary ancestry in the context of the TACK+L superphylum. Beside the use of cutting edge techniques for cultivation, metagenomics and stable-isotope-based imaging, a novel method will be developed for in situ metatranscriptomic analyses of archaea. This project will give fundamental insights into the ecological success of Archaea in commonplace environments and into the biology of the closest living prokaryotic relatives of Eukaryotes. Reconstructing the ancestral gene repertoire and biological features of lineages of the TACK+L superphylum will help resolve the enigma of the emergence of eukaryotes.

Keywords: archaea,microbial comparative genomics,phylogenomics,single cell analysis,microbial cultivation,early eukaryotic evolution
SUpporting evolution and adaptation of PERsonalized Software by Exploiting contextual Data and End-user feedback (SUPERSEDE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Spain,Germany,Italy,Switzerland,Switzerland
Call: Tools and Methods for Software Development (H2020-ICT-2014-1, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 3852362.5
EU funding (EUR): 3246675.0
Participants: 9
Project status: CLOSED

The number of available software applications in the form of web services, mobile apps, etc., is dramatically increasing over the years. This software exploits data collected through various sensors, and online data sources. Its users can access it through a variety of devices, mostly based on mobile technology. Software providers can hardly predict the acceptance of the applications they deliver. The great diversity in execution contexts and user preferences makes it difficult to personalize the software to fit all users’ needs. The complexity of those systems and the data involved turn out to be a solution to the problem and offer new opportunities for software engineers The SUPERSEDE project proposes a feedback-driven approach for software life cycle management, with the ultimate purpose of improving users’ quality of experience. Decisions on software evolution and runtime adaptation will be made upon analysis of end-user feedback and large amount of data monitored from the context. An integrated platform will articulate the methods and tools produced in the project. The project will provide advancements in several research areas however, the major contribution will be in integrating methods and tools from the mentioned areas, thus providing a new solution framework for software evolution and adaptation for data-intensive applications Three use cases have been identified to provide a solution, which is based on the needs of different companies. They are representative for different data-intensive application domains (i.e. energy consumption, sport event webcasting). This diversity also allows a validation of the methods and tools produced to ultimately provide evidence of potential for productivity gains. CONSORTIUM: 8 partners with large scientific, dissemination and exploitation expertise on the topics of the project. Balanced consortium from different perspectives: geographical (5 countries) and profile (4 academic partners + 4 companies, 2 large and 2 SMEs).

Keywords: software evolution,software adaptation,software qualities,end user feedback,contextual data,decision support systems
Smart integrated Robotics system for SMEs controlled by Internet of Things based on dynamic manufacturing processes (HORSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Spain,Slovenia,Greece,Poland,Greece,France,France,France,Netherlands,Netherlands,Netherlands
Call: ICT Innovation for Manufacturing SMEs (I4MS) (H2020-FoF-2015, 2015)
Start date: 2015-11-01
End date: 2020-07-31
Duration (months): 57.0
Total project cost (EUR): 8851778.29
EU funding (EUR): 7945601.0
Participants: 17
Project status: CLOSED

HORSE aims to bring a leap forward in the manufacturing industry proposing a new flexible model of smart factory involving collaboration of humans, robots, AGV’s (Autonomous Guided Vehicles) and machinery to realize industrial tasks in an efficient manner. HORSE proposes to foster technology deployment towards SMEs by developing a methodological and technical framework for easy adaptation of robotic solutions and by setting up infrastructures and environments that will act as clustering points for selected application areas in manufacturing and for product life cycle management (production and/or maintenance and/or product end of life). The main strategy builds on existing technology and research results in robotics and smart factories and integrates them in a coherent framework. The suitability of the resulting framework is not only driven by but will be validated with end-users - manufacturing companies- in two steps: In the first, the joint iterative development of the framework together with selected end-users will take place (Pilot Experiments). In the second, its suitability and transferability to further applications will be validated with new end users, which are recruited by an Open Call mechanism. The novel approaches of HORSE are the integration of concepts such as (physical) human-robot interaction, intuitive human-machine interfaces, and interaction between different robots and machines into an integrated environment with pre-existing machines and workflows. Safety of the human worker as well as reduction of health risks through physical support by the robotized equipment will contribute to better overall manufacturing processes. In these, pre-defined workflows to be customized are the basis for servitisation, for the entire value chain that allow rapid reconfiguration of the robots based collaborative production processes. HORSE aims to foster advanced manufacturing technology deployment by industries and especially SMEs.

Keywords: advanced manufacturing robotics
ChaperoneRegulome: Understanding cell-type-specificity of chaperone regulation (ChaperoneRegulome)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1992500.0
EU funding (EUR): 1992500.0
Participants: 2
Project status: SIGNED

Protein misfolding causes devastating health conditions such as neurodegeneration. Although the disease-causing protein is widely expressed, its misfolding occurs only in certain cell-types such as neurons. What governs the susceptibility of some tissues to misfolding is a fundamental question with biomedical relevance. Molecular chaperones help cellular proteins fold into their native conformation. Despite the generality of their function, chaperones are differentially expressed across various tissues. Moreover exposure to misfolding stress changes chaperone expression in a cell-type-dependent manner. Thus cell-type-specific regulation of chaperones is a major determinant of susceptibility to misfolding. The molecular mechanisms governing chaperone levels in different cell-types are not understood, forming the basis of this proposal. We will take a multidisciplinary approach to address two key questions: (1) How are chaperone levels co-ordinated with tissue-specific demands on protein folding? (2) How do different cell-types regulate chaperone genes when exposed to the same misfolding stress? Cellular chaperone levels and their response to misfolding stress are both driven by transcriptional changes and influenced by chromatin. The proposed work will bring the conceptual, technological and computational advances of chromatin/ transcription field to understand chaperone biology and misfolding diseases. Using in vivo mouse model and in vitro differentiation model, we will investigate molecular mechanisms that control chaperone levels in relevant tissues. Our work will provide insights into functional specialization of chaperones driven by tissue-specific folding demands. We will develop a novel and ambitious approach to assess protein-folding capacity in single cells moving the chaperone field beyond state-of-the-art. Thus by implementing genetic, computational and biochemical approaches, we aim to understand cell-type-specificity of chaperone regulation.

Keywords: molecular chaperones,heat shock proteins,stress,protein misfolding,gene regulation
Depicting Species: The Role of the Image in Modern Biology 1750-1950 (SPECIMEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2022-07-31
Duration (months): 36.0
Total project cost (EUR): 278840.64
EU funding (EUR): 278840.64
Participants: 2
Project status: CLOSED

This project investigates the visual cultures of zoological systematics informed by practices, techniques, genres, ideas, materiality, norms, producers, and audiences. Approaching systematics through its rich pictorial legacy, I explore how thinking through images in using them as research tools produces distinct species concepts and how images used as training or teaching devices informed species concepts. The timeframe of this investigation spans three centuries and explores two hundred years of biological research between Linnaeus’ first attempt to standardize zoological nomenclature in 1758 and the “Modern Synthesis” of evolution and heredity in the 1930s and 1940s. On the basis of the empirical examination of archival collections and printed materials, I examine the functions, production, and usage of zoological illustrations within biological research (objective 1) and follow their circulation among lay audiences (objective 2). I will approach the material from an interdisciplinary perspective. This involves first an iconographic method as a foundation for a comparative evaluation. I draw here on both scientific and artistic practices. Second, I embed the production of zoological illustrations within the framework of cooperative knowledge production between different groups of actors stemming from different intellectual, educational, social, and national backgrounds. This will be the first study of the transformation of pictorial scientific practices in systematics between 1750 and 1950 and how they redefined the boundary between expert and lay audiences. The book resulting from this research will draw a vivid panorama of scientific knowledge production carried out by zoologist, artists, technicians, and amateur scientist.

Keywords: history of biology,natural history,intellectual history,visual studies,popular science,epistemology,science education,museum,history of print media,taxonomy,species,photography
Developing heterocylic sulfinates as general coupling partners in transition metal catalysed processes (DECOCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-29
End date: 2021-06-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project focuses on the development of heterocylic sulfinates as general coupling partners in transition metal catalyzed processes, through a desulfinative coupling process that has already shown promising results. Previously, aryl boronic acids, and related boronates, are some of the most versatile and widely used reagents available to synthetic chemists. However, their use is limited due to the low efficiency, poor stability and difficulty in preparation of many heterocycle-derived boronic acids. The Willis laboratory in Oxford has been exploring alternatives to heterocyclic boronic acids in coupling processes, and has recently established that pyridine sulfinates are excellent coupling partners in palladium-catalyzed coupling reactions with aryl and heteroaryl halides. Very recently they have shown that this chemistry can be extended to the use of alternative heterocycles, such as pyrimidine, pyrazine, pyridazine, imidazole, pyrazole and indazole cores. The use of these heterocycle sufinates addresses many of the limitations of the corresponding boronic acids (ease of preparation and use, storage stability and reactive efficiency). The remarkable utility of heteroaryl sulfinates in coupling with (hetero)aryl halides suggests that the chemistry could be extended to tackle several remaining challenges associated with heterocycle functionalization, specifically elaborating heterocycle cores with small (cyclic)alkyl substituents, and introducing diverse N- and O-based nucleophile coupling partners. Protected versions of these sulfinates, so called masked sulfinates, will also be developed. These three areas of investigation encompass the scope of the proposal.

Keywords: desulfinative coupling,organometallic catalysis,heteroaryl sulfinates
Towards Artificial Enzymes: Bio-inspired Oxidations in Photoactive Metal-Organic Frameworks (Supramol)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 1979366.0
EU funding (EUR): 1979366.0
Participants: 1
Project status: CLOSED

Metal-organic frameworks (MOFs) are key compounds related to energy storage and conversion, as their unprecedented surface areas make them promising materials for gas storage and catalysis purposes. We believe that their modular construction principles allow the replication of key features of natural enzymes thus demonstrating how cavity size, shape, charge and functional group availability influence the performances in catalytic reactions. This proposal addresses the question of how such novel, bio-inspired metallo-supramolecular systems can be prepared and exploited for sustainable energy applications. A scientific breakthrough that demonstrates the efficient conversion of light into chemical energy would be one of the greatest scientific achievements with unprecedented impact to future generations. We focus on the following key aspects: a) MOFs containing novel, catalytically active complexes with labile coordination sites will be synthesised using rigid organic ligands that allow us to control the topologies, cavity sizes and surface areas. We will incorporate photosensitizers to develop robust porous MOFs in which light-absorption initiates electron-transfer events that lead to the activation of a catalytic centre. In addition, photoactive molecules will serve as addressable ligands whereby reversible, photo-induced structural transformations impose changes to porosity and chemical attributes at the active sites. b) Catalytic studies will focus on important oxidations of alkenes and alcohols. These reactions are relevant to H2-based energy concepts as the anodic liberation of protons and electrons can be coupled to their cathodic recombination to produce H2. The studies will provide proof-of-concept for the development of photocatalytic systems for the highly endergonic H2O oxidation reaction that will be explored using most stable MOFs. Further, gas storage and magnetic properties that may also be influenced by light-irradiation will be analysed.

Keywords: metal organic frameworks,coordination clusters,oxo clusters
A Quantum Boost for Atomic Sensors (QBAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-09
End date: 2018-08-08
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Atom interferometry provides extremely sensitive measurements of quantities such as rotations and accelerations. This project will theoretically investigate how quantum entanglement between atoms and photons can enhance the sensitivity of atom-interferometry. The aim of this project is to drastically enhance the sensitivity of atom interferometers, to deliver practical sensing devices of unprecedented sensitivity. This increased sensitivity may lead to new technologies, such as ultra-sensitive gravity gradiometers for the detection of mineral reserves, as well as important applications to fundamental physics, such as tests of fundamental theories beyond the standard model.

Keywords: atom interferometry,quantum squeezing,atom light entanglement
VessConnect “Plug Flow” innovative technology providing patients a safer, more effective and less costly procedure for vascular anastomosis (PLUGandFLOW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Proposal title* VessConnect “Plug & Flow” innovative technology providing every year to 270.000 European patients a safer, more effective and less costly procedure for vascular anastomosis ACRONYM: PLUGandFLOW Free keywords vascular anastomosis, microvascular anastomosis, microsurgery, NiTiNol, advanced materials, bio-absorbable Shape Memory Polymers, Advanced Material Innovation applied to surgical device, microsurgery Abstract: Vascular anastomosis, the surgical union of two blood vessels, has been technically performed in the same way for the last 100 years: suturing both ends of the vessels with microsutures. Even though several devices have appeared to ease the proceeding, none of them could improve traditional techniques. The result is a time-consuming procedure, with a long learning curve, which is not widely spread in private health systems because of its dangers and lack of efficiency and reliability. Surg Solution’s, is a start-up company founded by two surgeons, one bio-medical engineer and a business consultant, that has designed, prototyped and solicited a PCT patent for a device, VessConnect, that will reduce costs and probabilities of failure in anastomosis procedures. The product, a stent-like device, relies on the shape-memory characteristics of NiTiNol. Vascular anastomosis is a widely spread surgical procedure used in organ transplants and general reconstruction surgery, among others. Vessconnect has the potential to impact on the health improvement of the 270.000 European patients that we estimate need a surgery involving an anastomosis every year. Surg Solution aims to gain with VessConnect, 45% market-share of microvascular anastomosis in top European Markets in 5 years, generating €18M on revenues by 2021 with a 77% EBITDA margin. VessConnect is at TRL6. We aim to launch the product by mid 2019, bringing to patients a safer surgery, to surgeons an easier procedure and to the healthcare system a more efficient solution to perform vascu

Keywords: vascular anastomosis,advanced materials,bio absorbable shape memory polymers,nitinol,poly caprolactone pcl multiblock copolymer,n butyl acrylate copolymer,6 diisocyanate 2,4 trimethylhe