Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Healthy Microbiota Avoiding Fractures during Ageing (HeMAFA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 2499993.0
EU funding (EUR): 2499993.0
Participants: 1
Project status: SIGNED

The basic research problem: Gradual loss of bone and muscle mass with ageing leads to increased risk of fractures in the elderly population. There is a large medical need for new fracture preventive therapies with minimal side effects and novel biomarkers that improve the prediction of fracture risk. The aim of the proposed research is to test our hypothesis that the increased fracture risk in elderly people is caused by an age-dependent unhealthy change of the gut microbiota (GM) composition, resulting in reduced bone and muscle mass, and thereby increased fracture risk. Methodology: We will identify age-dependent GM signatures that are causally associated with reduced bone and muscle mass and thereby increased fracture risk in elderly subjects. A major emphasis will be to determine causality of the GM using a variety of recently developed GM-related genetic instruments (for GM composition and function as well as for circulating metabolites) as exposures in 2-sample Mendelian randomization (MR). In addition, we will use faecal microbiota transplantation (FMT) to directly determine causality of age-dependent GM alterations for reductions in bone and muscle mass. Based on this information, we will design candidate probiotic treatments and test their efficacy in mouse osteoporosis models. Finally, we will determine the clinical usefulness of the identified GM signatures for fracture prediction in elderly subjects. Research progress beyond the state of the art: We will employ three complementary methods, 2-sample MR, FMT, and treatment studies, to determine causality for GM on musculoskeletal parameters. For this research, we have established large well-characterized Nordic cohorts with metagenome sequence data and information on incident fractures available in 2023. Identification of a GM-signature with a robust effect on age-related bone and muscle loss will open-up completely new avenues to avoid fractures in elderly.

Keywords: fracture,mendelian randomization,ageing,gut microbiota
A European Network of Research Infrastructures for CO2 Transport and Injection (ENCASE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Norway,France,Italy,Netherlands,United Kingdom,Poland
Call: R&D for the next generation of scientific instrumentation, tools and methods (HORIZON-INFRA-2022-TECH-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 7454097.0
EU funding (EUR): 7454093.0
Participants: 20
Project status: SIGNED

The EU has committed to reducing greenhouse gas emissions by 55% by 2030 and becoming carbon neutral by 2050. Deployment of CO2 Capture and Storage (CCS) from different industrial sectors across Europe is a powerful fast track approach to abate CO2 emissions. CO2 transport and injection are the essential links between capture sites and storage reservoirs. The goal of ENCASE is to contribute to a safer, more cost-effective, and environmentally friendly CO2 transport and well injection. ENCASE aims to continuously improve 7 world-leading CCS-related research infrastructures (RIs) in the consortium with state-of-the-art scientific instruments, tools and methods to be the backbone for research and development of CCS technologies. Co-development of technologies will enhance the capability of RIs, increase RI personnel’s competence and enable these RIs to better address and close key knowledge gaps. ENCASE will safeguard and increase the competitiveness of these European RIs through strong collaboration with the CCS infrastructure operators, service companies, academia, and SMEs. The RIs will be available for the industry/SMEs for prototyping their new equipment/technology, e.g., pumping concepts, metering technologies, and simulator tools for monitoring, controlling and predicting the CO2 streams with impurities. The high-quality data produced in ENCASE will lift the knowledge level of industry and academia, which will contribute to the development of innovative companies and the education of future workforce for the CCS industry. Social innovation labs and co-creation initiatives will be developed by involving different stakeholders to address specific societal needs and better integrate the RIs in the local communities. Our success will improve the design and operation of CCS infrastructures and meet the EU climate goals. Thus, the enhanced research capacity build by ENCASE will benefit scientific community, industry, policy-makers, environment and society.

Keywords: ccus,co2 transport and well injection,pipeline and ship,research infrastructure,flow metering,impurity,advanced scientific instruments,simulator tools,models,co creation,social innovation
Cloud-Edge-IoT Spheres of Large-Scale Pilots (CEI-Sphere)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Coordination and support actions
Countries involved: Spain,United Kingdom,Belgium,Denmark,Czechia,Italy,France,Germany,Netherlands
Call: Platform Building, standardisation and Up-scaling of the ‘Cloud-Edge-IoT’ Solutions (Horizontal Activities - CSA) (HORIZON-CL4-2024-DATA-01, 2024)
Start date: 2024-10-01
End date: 2027-03-31
Duration (months): 30.0
Total project cost (EUR): 2001625.0
EU funding (EUR): 2001625.0
Participants: 11
Project status: SIGNED

CEI-Sphere aims to support the development of an open, interoperable, and competitive ecosystem that encompasses the Cloud-Edge-IoT Large-Scale Pilots (LSPs), particularly those funded under the CL4-2024-DATA-01-03 call and their stakeholders. CEI-Sphere will play an accretive role in supporting the Commission and the LSP community to achieve better outcomes including (i) gaining a detailed understanding of the use-cases, their level of maturity, their value chain and their markets (ii) identifying horizontal challenges and synergies that can help fast track results (iii) supporting the development of open ecosystems through interoperability (iv) securing the interoperability, robustness and scalability of the CEI solutions through standards that can be promoted internationally (v) connecting to other CEI deployment drivers, including technological drivers, such as the mass adoption of Gen AI, regulatory and environmental drivers. To this end, CEI-Sphere will produce (1) a high-level reference CEI architecture, (2) use-case catalogue with TRL, value chains, rules of engagement and target markets (3) CEI Market analysis reports and forecasts (4) GTM guideline for LSPs, (5) open/closed source development boundary minimum interoperability standard, (6) guidelines on Privacy Enhancing Technologies (7) CEI tech backbone kit for open edge ecosystem based on holistic assurance framework, (8) CEI certification framework, (9) 10 synergies to facilitate the sharing of insights, resources, and best practices, and (10) an innovation ecosystem visualisation tool with 50+ CEI use cases. CEI-Sphere brings together a strong consortium comprised of 3 SMEs (BLU, TRIA, TRUST-IT), 2 companies (IDC, VDI), 2 industry associations (AIOTI, INSIDE) and 4 affiliated entities with specific relevant expertise. CEI-Sphere’s outputs dissemination through a detailed exploitation plan, to reach CEI Tech Adopters, Providers, Facilitators & Innovators, will maximise the project’s impact.
Development of a minimally-invasive sampling protocol for the study of manuscripts and other historical documentary materials (NanosamplinK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

NanosamplinK is an innovative research project that aims at developing a minimally-invasive sampling protocol for historical manuscripts and documentary materials. It involve the use of several formulations of hydrogels and organogels which will serve as a conduit for solubilizing and absorbing the superficial layers of colored applications, preserving the integrity of the materials being analyzed. The gels will be tested on modern ink and paint reproductions, as well as on real case studies. The project focuses on striking a balance between minimizing invasive color changes on the artworks, selecting the best-performing gels for extracting specific compounds (water-soluble and non-water-soluble), and surpassing the detection limit of the intended high resolution molecular techniques. Rooted in conservation-restoration, material science, and art history, NanosamplinK benefits from expertise in heritage science, mentorship from leading experts in conservation, molecular analysis, chemistry, and nanotechnology. It is a highly interdisciplinary and international project, with a Green character, and significant implications in terms of broadening the commercial viability of these gels.

Keywords: written heritage,inks,paints,sampling,art conservation,scientific analysis of art,technical art history
Pandemic literacy and viral zoonotic spillover risk at the frontline of disease emergence in Southeast Asia to improve pandemic preparedness (PANDASIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Norway,Germany,United Kingdom,Thailand,Sweden,Portugal
Call: Pandemic preparedness (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 4017764.25
EU funding (EUR): 3961639.0
Participants: 11
Project status: SIGNED

The PANDASIA project addresses the call by providing a framework that will increase our understanding of the biology of viruses with emerging infectious disease potential and their interaction with humans, animals and the environment and translating this understanding into proactive preventative actions. Such research is crucial for providing evidence-based knowledge and tools for better integrative public health measures for local and national actors. We will develop models to identify and predict drivers of disease emergence, which will be evaluated with real world data, refined and used to develop health and pandemic literacy intervention strategies that reduce risk of future viral emergence, thereby reducing the burden of zoonotic spillover to human health. Since pandemics arise at a local level it is important to engage with local communities and health, environment and agriculture authorities to improve their health and pandemic literacy to ensure adequate preparedness and vigilance for future spillover events and human, animal and environmental health threats. Understanding spillover dynamics and threats at local levels in emerging disease hotspot areas, such as Southeast Asia, is important for the European Union to improve preparedness and the ability to respond quickly to health emergencies and cross-border threats. The identified drivers are likely generalizable to other emerging infectious disease hotspots in the region and if successfully implemented in SE Asia could be adapted to other hotspot regions, such as in South America and Africa.

Keywords: health literacy,wildlife ecology,society,social science,co creation,intervention
Miniaturized sensor system for continuous soil-nutrient monitoring based on integration of a lab-on-a-chip microfluidic cartridge with an optoelectronic detection unit (SOILMONITOR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2022-11-01
End date: 2026-01-31
Duration (months): 39.0
Total project cost (EUR): 2499716.25
EU funding (EUR): 2499716.0
Participants: 1
Project status: SIGNED

The soil of the earth is the basis of our life. Efficient use of soil is needed for feeding the growing population. Contaminated soil needs to be regenerated to protect the quality of drinking water and more generally the ecosystem. Here, we propose a highly miniaturized sensor system for monitoring nitrate, ammonium, and phosphate based on integration of a lab-on-a-chip microfluidic cartridge with an optoelectronic detection unit. The optoelectronic detection chip employs the directional organic light emitting diode (OLED) we developed within the ERC PoC project BEAMOLED. This kind of OLED allows for direct integration of the optoelectronic chip with the microfluidic cartridge providing a new level of miniaturization of the optical readout measurement system. We propose the use of colorimetric assays based on starting with standard assays and improving performance using nanozyme catalysis. A hydrophilic ceramic as inlet to a microfluidic channel is proposed for intake of soil solution. Reagents as well as the waste are stored in the sensor system. We target a system size of 3 cm x 3 cm x 5 cm for maintenance-free operation in the soil for a duration of one year for in-situ monitoring of 100 data points per nutrient. In a soil-science study the soil-solution extraction into the microfluidic will be investigated for soils with a wide range of pore size distributions, bulk densities, pore-space connectivity, and soil water content to validate the extraction approach scientifically. Pot and field tests in agriculture and soil remediation are planned for validation in application-relevant environments of two potential markets and to develop market readiness. Our aim is to start a spin-off company after completion of this project. By the parallel development of the technology and business side with an interdisciplinary team from electrical engineering, chemical engineering, soil science, and economics/entrepreneurship an iterative adjustment process is achieved.

Keywords: entrepreneurship,on line monitoring,lab on a chip,organic optoelectronics,colorimetric assay,nitrate,ammonium,phosphate,precision agriculture,soil remediation,wireless communication
Lay Women: International Experts and Theologians avant-la-lettre. Legacies and Entangled Histories (1945-1962) (TheoFem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 3
Project status: SIGNED

The overarching objective of this project is to demonstrate European Catholic lay women's vital contributions as international agents, thinkers and theologians avant-la-lettre, from the end of World War II up to the celebration of the Second Vatican Council (1945-1962). While several studies have dealt with lay (and religious) women during and after the Council, their pioneer role as intellectuals and international experts in the pre-conciliar years has significantly received less attention. The history of this period has mostly been written in strikingly national, secular and rather masculine terms. A crucial aspect of the period was the Church’s attempt to expand the ranks of lay International Catholic Organisations (ICOs). As a result of their engagement in shaping pastoral strategies, international policies and agenda setting, lay women in positions of leadership became experts, they travelled extensively, and gradually adopted ‘female’ forms of agency as a route into male-dominated arenas (theology, international relations and action) By paying particular attention to the entangled history of Belgium and Spain (both understood in their relationship to the wider Spanish and French speaking Catholic worlds), by adopting an interdisciplinary approach (political and social sciences, visual and intellectual cultures, theology, anthropology) and a gender perspective, the project will 1) systematically recover and establish a ‘genealogy’ of lay women's intellectual agency; 2) map and conceptualise their collective action and transnational networks; 3) illustrate the strategies used to consolidate communities of secular and religious knowledge (including alternative forms of governability); 4) visualise their legacies. In this manner the project aims to contribute to reconfigure public perceptions about women in positions of leadership, and to the promotion of gender equality and more reflective European societies.

Keywords: women and gender studies,transnational networks,religious history,international catholic organisations,humanitarianism
Discovery of new Frontal Temporal Dementia multimodal spectral markers in biofluids. (IR4FTD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Australia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 287152.32
EU funding (EUR): 287152.32
Participants: 3
Project status: CLOSED

The central aim of the project is to apply multimodal spectroscopy combined with machine learning to identify a fingerprint for Frontal Temporal Dementia (FTD) and Alzheimer’s disease (AD) in saliva and plasma. FTD is the second most common dementia and usually affects individuals younger than 60 years old. FTD is difficult to diagnose, since there is no single exam that determines the disease, but instead many costly or painful exams that together link the disease. Some of the symptoms of the disease may be confounding with others such as AD. While the usual search for biomarkers focuses on individual patterns, the present proposal is to use a holistic approach. Vibrational spectroscopy provides a snapshot of the entire chemical finger print in a label-free way. In this project, samples from FTD, AD, and healthy subjects of >45 years old, will be analysed using Raman, mid and near infrared spectroscopy @Monash University in Australia, and complemented with Mass Spectrometry on the same samples @ICGEB in Italy. Advanced machine learning tools provide a powerful approach for data analysis unravelling hidden trends, correlations and also identify the main contributions that characterize the type of sample. The spectra recorded using the extended wavelength range encompassing the mid-infrared and near-infrared spectral regions will be processed with state-of-the-art machine learning tools to identify the molecular phenotype and establish markers in patients with TDP and AD. These findings will pave the way to the development of a new screening tool that would decrease the costs associated with the current diagnosis of FTD and in general for neurodegenerative disorders.

Keywords: ftir,nir,raman,frontal temporal dementia,biomarkers
Artificial Intelligence Driven Design of Resorbable Implants (AIDDRI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-16
End date: 2026-09-15
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

In recent years, the importance of biomedical implants has surged in addressing various medical conditions, including bone fractures, heart ailments, and other healthcare challenges. As healthcare complexities continue to escalate, there is a growing demand for biodegradable implants. Pioneering research in medical science is driving the scientific community toward the latest generation of biomedical implants, which closely mimic natural bone and tissues, greatly enhancing their biocompatibility. For instance, temporary medical implants are now based on biodegradable metals like magnesium (Mg), zinc (Zn), and iron (Fe), offering promising potential. Mg alloys, in particular, have a long and illustrious history, especially in bone-support applications. Their elastic modulus closely matches that of natural cortical bone, thereby reducing the occurrence of stress-shielding effects. Furthermore, the body's established pathways for excreting excess Mg via urine make Mg-based alloys ideal candidates for resorbable implants. It is anticipated that Mg-based implants will degrade within a suitable timeframe within the human body. However, there are challenges associated with metallic implants. Firstly, achieving a uniform and predictable degradation rate of implant within the human body. Complete dissolution of the implant after fulfilling its function can provide substantial benefits to the patient by eliminating the risks and costs associated with secondary surgeries and complications, such as hypersensitivity. The second major challenge lies in using biologically safe, low-alloyed magnesium, which, unfortunately, results in high corrosion rates and the formation of hydrogen bubbles that can hinder the healing process. To address these challenges, we propose the development of a novel methodology for producing Mg-based alloys suitable for biodegradable, resorbable implant applications, offering excellent performance.

Keywords: biomedical implants,resorbable implants,biodegradable alloys,artificial intelligence,machine learning