Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
RumenShield Dairy - Non-Medicated Feed Additive to Improve Milk Yield in Dairy Cows (RumenShield Dairy)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Ireland,Belgium
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2019-07-01
End date: 2022-06-30
Duration (months): 36.0
Total project cost (EUR): 2541393.75
EU funding (EUR): 1775095.01
Participants: 4
Project status: SIGNED

Antibiotic growth promoters have been used extensively throughout the world to increase milk output in dairy farming, leading to an average 5.4% increase in milk yield. This leads to greater productivity and profitability. Due to concerns over antibiotic-resistance and overuse of antibiotics, these have been banned in the EU since 2006. While non-antibiotic replacement products are used in the EU, these are not as effective. As such, EU dairy farms are at a competitive disadvantage when competing globally. Mayo Healthcare has developed RumenShield Dairy, a non-antibiotic feed additive which acts upon the rumen microbial community to enhance feed efficiency, improve milk output and health of the animal. In preliminary trials has shown an increased milk yield of 7.16% - leading to increased revenue of €173/cow, with a 3.8x return on investment seen. RumenShield Dairy has also shown additional benefits to the cow including reduced rates of lameness, mastitis and increased rates of fertility, which are estimated to save €275-300/cow. RumenShield Dairy acts upon methanogenic bacteria in the rumen. In vitro studies have shown use of RumenShield Dairy can reduce methane emissions by an average of 63%. This has the potential to transform the EU dairy sector, leading to a €4.067Bn increase in dairy output, with a potential 2.74% reduction in EU greenhouse gas emissions. Increased productivity and reduced carbon footprint shall make the EU dairy sector more competitive internationally, leading to increased exports, job creation and sustainable food production. This multi-party FTI project will optimise the formulation and then manufacture RumenShield Dairy. It will complete large-scale field studies demonstrating superiority over current gold-standard products, leading to a scientific opinion from EFSA regarding product use. The total market opportunity in the EU is €864m, with a total global market size of €2.559Bn. We aim to launch the product on the market during Q3, 2021.

Keywords: milk,dairy,antibiotics,productivity,growth promoters,methane,greenhouse gas
Energy Trusted Advisor for Buildings (ETA4B)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ETA4B (Energy Trusted Advisor for Buildings) project promotes the development of an embedded energy optimization system collaborating with existing devices, providing citizens with innovative applications and services in the field of energy efficiency of buildings, making home more smart. The solution includes a multi-protocol electronic unit to be easily installed in houses and small buildings, providing an open-framework web-based platform with energy-related data flow for supporting the decision making process for end users. Benefits for users are in terms of energy saving (cheaper bills), CO2 emissions reduction and, for the ones being “prosumers” (energy users that also produce energy in their buildings), low production costs and higher profits. For Tera Srl, the challenge is to enter in the energy efficiency market thus enhancing company’s profitability. The main customers will be “prosumers”, addressed through an innovative commercial approach, based on web applications managed by skilled companies selling a modular and scalable service, rather than a device that will be introduced in the energy efficiency market for small buildings. Strong innovation also lies in the combination of automatic SW updating capability at front-end (no needs for maintenance and ease of use) and powerful reasoning engines at back-end. These SW engines are based on energy-model calculations and big-data like algorithms, running both on private and public data-base (open-data), delivering “customized” performance indexes to the users. To demonstrate the feasibility of ETA4B, Phase 1 activities will focus on specific components such as target market, partner search, value proposition, compliance to cutting-edge standards and development platforms, financial sustainability and business model. ETA4B responds to EU challenges concerning the market uptake of a sustainable solution, a new system for energy efficiency in buildings, seizing the European and global markets.

Keywords: energy efficient products and services for buildings,smart and sustainable use of renewable,smart home,ict based solution,users data,big data,open data,decision support system,energy prosumer
DiscardLess – Strategies for the gradual elimination of discards in European fisheries (DiscardLess)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Iceland,Spain,Italy,Spain,Spain,Ireland,Ireland,Norway,Norway,Belgium,Poland,Belgium,Greece,France,France,France,Denmark,United Kingdom,Canada,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,Denmark
Call: Towards a gradual elimination of discards in European fisheries (H2020-SFS-2014-2, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 5551125.25
EU funding (EUR): 5000000.0
Participants: 32
Project status: CLOSED

The European Union has committed to the gradual elimination of discarding. DiscardLess will help provide the knowledge, tools and technologies as well as the involvement of the stakeholders to achieve this. These will be integrated into Discard Mitigation Strategies (DMS) proposing cost-effective solutions at all stages of the seafood supply chain. The first focus is on preventing the unwanted catches from ever being caught. This will promote changes in gear using existing and innovative selectivity technology, and changes in fishing tactics based on fishers’ and scientists’ knowledge. The second focus is on making best use of the unavoidable unwanted catch. We will detail technical and marketing innovations from the deck, through the supply chain to the final market, including monitoring, traceability and valorization components. DiscardLess will evaluate the impacts of discarding on the marine environment, on the economy, and across the wider society. We will evaluate these impacts before, during and after the implementation of the landing obligation, allowing comparison between intentions and outcomes. Eliminating discards is as much a societal challenge as a fishery management one, so we will also evaluate stakeholders’ perception of discards. DiscardLess will describe the changes in management and the associated governance structures needed to cement the process. We will propose approaches to managing discards in a range of case study fisheries across Europe, encompassing differences in specific discarding issues. All these innovations will be combined in integrated Internet based interactive programs (DMS toolbox) that will help fishers to evaluate the present and future situation and to take a more qualified decision of how to adjust to the new regime. Also, we will disseminate the outcome of the project and maximize knowledge transfer across Europe through an educational environment – teaching the next generation – as well as more conventional routes.

Keywords: environmental impacts of discard,discards mitigation,governance,fisheries policies,seafood processing,traceability,fisheries selectivity
Identification of the proteasome machinery targets in human cancer (Proteasome in cancer)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Poland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 146462.4
EU funding (EUR): 146462.4
Participants: 1
Project status: CLOSED

The 26S/20S proteasome and immunoproteasome machinery is the major protein degradation system in human cells and a strongly oncogenic factor upregulated in most human neoplasias of various tissues. Thus, it is a target of clinically approved treatment protocols in human multiple myeloma and mantle cell lymphoma. However, clinical trials have shown a limited effect of proteasome inhibitors in solid tumors and their metastases, despite initial encouraging results in vitro and in xenografts. The main objective of the following project is to understand the oncogenic contribution of the human proteasome machinery to the proteome and transcriptome of human cancer cells and to use this knowledge to improve the anti-cancer therapeutic approaches targeting the proteasome and its downstream effectors, in human cancer types causing most deaths in the European Union – lung, colon/rectum and pancreatic cancers. The main research hypothesis is that the unknown mechanisms downstream of the human proteasome machinery are critical for cancer progression and will be effective as drug targets in the treatment of the solid tumors and their metastasis. Discovering these mechanisms using proteome-scale mass spectrometry analysis combined with RNA-sequencing will allow in this project to: (i) identify novel proteasome targets and understand reprogramming of human neoplastic cells by the proteasome machinery on the basic level in multiple myeloma, lung, colon and pancreatic cancer cultured cells, (ii) understand the reason for the exceptionally efficient therapeutic effect of the proteasome inhibitor carfilzomib in multiple myeloma compared to solid tumor cancer cells, and (iii) test in frozen/fixed tumor material, cell cultures the functional validity of the discovered proteasome targets as therapeutic target candidates in lung, colon and pancreatic cancers – which could increase efficiency or bypass targeting of the proteasome machinery by carfilzomib in the solid tumors

Keywords: proteasome,cancer,carfilzomib,proteomics,transcriptomics,multi omics
The molecular mechanisms of sex determination in a malaria parasite (MalariaSex)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

Sexual reproduction is an obligate stage in the complex life cycle of Plasmodium parasites, the causative agent of malaria. While cyclic asexual replication of the parasite in the vertebrate host is associated with all clinical symptoms of malaria, transmission of the disease to a new host relies on sexual reproduction of the parasite in the mosquito. Transmission and reproductive success depend on the ability of malaria parasites to produce fertile male and female gametes at an optimal ratio. Haploid malaria parasites lack sex chromosomes, and sex-ratio is an adaptive and changeable trait to optimize transmission success in response to varying conditions, including multiplicity of infection and immune status of the host. The molecular mechanisms of sexual development hold the key to new transmission blocking interventions and to a broader understanding of how life cycle decisions in an important group of parasites can be regulated. Recent breakthroughs have identified a master regulator for commitment to sexual development, but how one transcription factor can give rise to the completely different gene expression programs of male and female gametocytes has remained elusive. Successful reprogramming experiments and genetic screens in a rodent model have now led to the identification of a small panel of genes, mostly encoding putative nucleic acid binding proteins which I propose here will unlock the question of how sex ratio is determined. By applying a combination of targeted biochemical, cell biological and genetic techniques I aim to characterize the function of three strongly supported, male-determining candidate genes. The obtained results will provide insights into the molecular mechanisms facilitating sex, and thus transmission, of malaria parasites. Moreover, this study will elucidate the fascinating biology of sex determination in an ancient and divergent eukaryote lacking sex chromosomes.

Keywords: sex determination,plasmodium,gametocytogenesis
Optimisation and Large-scale Commercialisation of Next Generation Cooling Equipment for Food Industry (nanoICE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2021-07-31
Duration (months): 33.0
Total project cost (EUR): 2480000.0
EU funding (EUR): 1736000.0
Participants: 1
Project status: CLOSED

Fisheries and aquaculture are critical sources of nutrition, income and livelihoods for hundreds of millions of people around the world. World per capita fish supply reached a new record high of 20 kg in 2014. Fish continues to be one of the most valuable traded food commodities worldwide with more than half of fish exports by value originating in developing countries. Despite industry growth there have been very modest technological advances in chilling fresh foods resulting in high levels of food waste, lost revenues and an unacceptable environmental impact. Production and Harvest International AS (PHI) is a seafood company with harvesting, processing and refrigeration technology expertise. It has identified a major gap in the cold chain market in the European Union and indeed worldwide and is targeting commercial opportunities throughout the fresh food value chain with nanoICE technology. The innovation of nanoICE responds to inefficiencies within the seafood and other fresh food industries. nanoICE is a patent pending technology that addresses the deficiencies of other commercial ice products used today by addressing the challenges faced by seafood harvesters and processors, namely: product weight retention; longer shelf-life; improved appearance; reducing hard labour; limited space for catch and trying to improve on these at an affordable price. nanoICE is game changing ice machine that delivers a combination of break-though solutions for all these challenges. Through nanoICE technology PHI’s mid-term goal is to become a market leader fresh chilling solution with a minimum of 8.5% of total EU market in aquaculture, medium and small sized fishing vessels and processors. PHI has licensed and recently acquired the IP rights to further refine the development nanoICE to become more commercially robust for the market place and enter the European market with a methodical business approach supported by full-scale grant funding.

Keywords: molecular ice,nanoice,ice generator,seafood industry,scraping method,scale up
Tiles: the first platform for shared entertainment (TILES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME business model innovation (H2020-SMEINST-2-2015, 2015)
Start date: 2016-02-01
End date: 2017-06-30
Duration (months): 17.0
Total project cost (EUR): 1651720.0
EU funding (EUR): 1156204.0
Participants: 1
Project status: CLOSED

The business model innovation described in this proposal addresses the new digital advertising sector within the larger creative industries. Advertising is essential to the success of the European digital market. Indeed, the wider digital ecosystem is fundamentally based on advertising, from media and content creators to search and email providers as well as social networks and apps. Europe’s digital advertising market represents a young sector, which continues to out-perform the overall economy, with a growth rate in 2014 of 11.6% compared to a mere 0.4% increase in EU GDP. In 2014, digital advertising powered the European internet economy to the tune of € 30.7 billion. New generations of consumers are using Internet, mobiles, digital media, etc., in ways that not only expand their range of creative experiences but also transform them from passive recipients of creative messages into active co-creators of creative content. Thus, the business model proposed aims at exploiting the business opportunities deriving from tcreative industry market trends and drivers. Mosaicoon proposes an inside out approach with the aim to create an ecosystem in which creatives and video makers as well as final users themselves should be an active part of the communication process of the Advertisers, allowing them to manage efficiently all the entire process of creation, distribution and monitoring of an online video campaign through one single dashboard. The Company’s goal is the creation and market launch of a completely automatized system called Tiles by the end of 2017. The company’s value proposition aims at bringing Brands to produce content, distribute it and monitor the results for observing real users’ engagement. The platform allows campaign budget optimization and the assessment of actual returns on communication investments. Moreover, Tiles will contribute to co-create value not only for Advertisers but also for creatives, video makers and publishers.

Keywords: business model,digital advertising,media,platforms,online,video,campaign,entertainment,smes
Synthesizing Meiotic Crossover Hotspots in Arabidopsis (SynthHotSpot)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 1999953.0
EU funding (EUR): 1999953.0
Participants: 1
Project status: CLOSED

The majority of eukaryotes reproduce sexually via meiosis. During meiosis homologous chromosomes pair and undergo reciprocal genetic exchange termed crossover. Meiotic recombination is a major evolutionary force and has a profound effect on patterns of genetic diversity in sexual species. Crossovers distributions are highly non-random and are typically focused in narrow hotspots. Study of hotspots throughout eukaryotes has revealed combinations of genetic and epigenetic factors that contribute to their distributions. In this proposal we will use the extensive genetics and genomics tools available in Arabidopsis to comprehensively dissect hotspot patterning. The strategic aim of the proposal is to use this knowledge to direct de novo hotspots to loci of choice. In the first aim we will use functional genomics to profile the chromosomal distributions of key recombination proteins and test the role of chromatin and higher-order structures in driving these patterns. In the second aim we will study individual hotspots at the fine-scale, to the resolution of individual polymorphisms, using amplification and sequencing of recombinant molecules from gamete DNA. To test genetic versus epigenetic control of hotspots we will use genome-editing to delete hotspot-associated CTT-repeat DNA sequence motifs, in addition to directing DNA methylation in order to epigenetically silence recombination. In the final aim we will use our combined knowledge of hotspot control to implement genome-editing technologies (TALENs & CRISPR-Cas9) during meiosis. This will allow us to rationally control hotspot locations, which will be definitive proof that our models for recombination control are correct. This technology will also accelerate breeding and genome-engineering of our most important crops, where recombination can be limiting. Finally, mapping hotspots will allow us to better understand patterns of natural genetic diversity, including detecting the signatures of selection.

Keywords: meiosis,recombination,hotspots,chromatin,genome editing
Biocontamination Integrated cOntrol of Wet sYstems for Space Exploration (BIOWYSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Italy,Estonia,France,France,Czechia,United Kingdom
Call: Space exploration – Habitat management (H2020-COMPET-2015, 2015)
Start date: 2016-01-01
End date: 2019-04-30
Duration (months): 40.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 10
Project status: CLOSED

Microbiological contamination can be attenuated, never eliminated. Space exploration requires development of reliable rapid significant and safe methods for preventing, monitoring and control the biocontamination within manned closed environments. These methods have to be automated, simple and conceived to decrease the (re-)supply mass from ground. Both space and terrestrial monitoring and prevention/mitigation methods are currently working separately instead of working in synergy. The proposed BIOWYSE project foresees development and demonstration of an integrated system suitable for future accommodation aboard the International Space Station (ISS) and from a long-term viewpoint, within Moon and Mars habitats. The BIOWYSE consortium will design, build and test single prevention, monitoring and mitigation modules. Thus, they will be integrated in a single system inside a compact breadboard and tested. Critical aspects or gravity-dependent technologies of the breadboard will be designed with the perspective of a future accommodation within a rack of the ISS (e.g.: in EDR-2 of Columbus), as a precursor of elements for long-duration space missions and future planetary outposts (e.g. Mars). In order to validate key technologies for the biocontamination control integrated system in real conditions and with representative features, the BIOWYSE project is based on the following major objectives: 1. Exploitation of ISS data from recent project related to the system functionalities 2. Designing single modules taking into account the intent of a demonstration aboard an International Standard Payload Rack 3. Building a system in order to test integrated key technologies 4. Developing and demonstrating operational techniques and processes for preventing, monitoring and mitigating the microbiological risk in water loops 5. Actively leveraging synergies between space and non-space partners, evaluating the system efficiency in real platforms for water loops and wet surfaces