Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Preparing the creation of Bio-Based Education Centres to meet industry needs and boost the contribution of the bioeconomy to societal challenges (BIObec)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Coordination and support actions
Partnership: BBI (Art-187)
Countries involved: Spain,Austria,Germany,Spain,Ireland,Italy,Ireland,Spain,Italy,Poland,Bulgaria,Finland,Poland,France,Czechia,Netherlands,Netherlands,Denmark
Call: Create and interlink bio-based education centres to meet industry's needs of skills and competences (H2020-BBI-JTI-2020, 2020)
Start date: 2021-09-01
End date: 2024-02-29
Duration (months): 30.0
Total project cost (EUR): 1595715.0
EU funding (EUR): 1499953.69
Participants: 19
Project status: SIGNED

Unlocking the full potential of the bioeconomy and its value chains requires a systematic and collaborative perspective for) the development of new skills, educational approaches and organisational solutions to provide education and training services. The aim of the BIObec project is to develop a holistic framework for multi-level Bio-Based Education Centers (BBEC) flexible enough to answer the present and future needs of the industry and of the surrounding ecosystem at local, regional, national and/or international levels. The project will design 6 BBEC pilots assuring a wide geographical coverage in Europe and addressing different topics linked to the variety of value chains and institutional contexts (vocational to university level, primary producers, processors, SMEs to MNCs). BIOBEC will clarify the needs of the different regional ecosystems and will provide detailed design, economic and financial assessment, governance plans for the educational training centres, as well as plans for life-long-learning programmes. It will also develop collaborative tools to maximize the synergies between them at the European and international level. The project will mobilise a network of 19 partners, which are leaders in Bioeconomy Education from different perspectives (ranging from academia to industry) together with a wide network of Implementation and Replication Working Groups and local stakeholders based in the EU. This network will pave the way for implementation and replication of the BBEC, in order to boost the contribution of the education sector for the development of the bioeconomy.

Keywords: bio based industry,skills and competences,education needs,education,governance,programs,budget,financing
DCAF E3 Ligase Exploration To Expand degRadation (DELETER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

PROteolysis TArgeting Chimeras (PROTACs) are molecules with therapeutic potential that induce degradation of target proteins involved in disease. PROTACs are composed of a ligand that binds an E3 ubiquitin ligase, chemically linked to a ligand for the target protein. Formation of a ternary complex between ligase, PROTAC and target protein leads to ubiquitination of the target, which is then recognised by the proteasome and degraded. The vast majority of PROTAC degraders developed to date recruit either the VHL or Cereblon E3 ligases, and only ~1% of the >600 known E3 ligases have been harnessed by this type of molecule. However, a given E3 ligase may not always form ternary complexes productive to ubiquitination for every target, and considerations such as organelle, cell type and tissue specificity warrant exploration of E3 ligases beyond those for which ligands currently exist. In this Fellowship, I will pursue the DCAF family of E3 ligases to expand the PROTAC toolbox. Two DCAF proteins have been successfully hijacked by degraders such as PROTACs, validating the family as exploitable for targeted protein degradation, and most DCAF proteins contain a WD40 repeat domain that is ligandable i.e. tractable to small molecule binding. Certain DCAF proteins also display organelle and tissue specificity. Beyond their potential for PROTAC development, DCAF proteins are therapeutically relevant in their own right and have been implicated in diseases such as cancer. DELETER will explore this high-potential yet understudied family of E3 ligases structurally, functionally and biophysically. High-quality recombinant proteins and relevant reagents produced in this project will be used to engage in screening campaigns to identify ligands that will be developed into PROTACs and inhibitors. The information, reagents and compounds generated for DCAFs will expand the scope of targeted protein degradation and has potential to increase the number of targets degradable by PROTACs.

Keywords: e3 ligase,targeted protein degradation,protac,dcaf,x ray crystallography,structural biology
Outside-in: How Bullying in Adolescence Gets Into The Mind and Under the Skin (Outside-In)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1494044.0
EU funding (EUR): 1494044.0
Participants: 1
Project status: SIGNED

Being bullied is a major stressor for many adolescents and it is recognized as a public health concern worldwide. Adolescents who are exposed to bullying are at increased risk for mental and physical health problems, which could even perpetuate into adulthood. Unfortunately, current understandings of how bullying can pose such deleterious effects remain poor, thus limiting our ability to inform prevention and intervention efforts. This project addresses this fundamental gap and substantially extends prior research in two unique ways. First, I will examine fine-grained processes as they occur within adolescents in real-time in their real-life as a crucial pathway for uncovering mechanisms underlying the negative effects of bullying. Second, I will adopt a multilevel perspective to examine the dynamic interplay between multiple psychological and biological processes and how they unfold over time. In this regard, I will examine the possibility that bullying influences gene expression processes resulting in a gene expression profile that increases risk for health problems. In a first study, I will use a longitudinal measurement burst design, allowing me to examine how bullying exposure can influence within-person processes over time at the daily level. I will assess psychological (e.g., emotional) and physiological (e.g., HPA-axis) functioning in situ, and I will use transcriptional profiling to examine how gene expression changes over adolescence as a function of bullying. In a second study, I will utilize data from the Netherlands Twin Register to identify monozygotic twins who differ from each other in their history of victimization in adolescence and examine their gene expression profiles in early adulthood, while accounting for genetic confounds. Together, this research will offer unprecedented insights about short- and long-term interplays between psychological, physiological and molecular processes through which bullying may get into the mind and under the skin.

Keywords: peer relations,bullying victimization,adolescence,psychophysiology,experience sampling method,gene expression profiling,biological embedding
TOWARD EFFICIENT ELECTROCHEMICAL GREEN AMMONIA CYCLE (TELEGRAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Sweden
Call: Developing the next generation of renewable energy technologies (H2020-LC-SC3-2020-RES-RIA, 2020)
Start date: 2020-11-01
End date: 2024-04-30
Duration (months): 42.0
Total project cost (EUR): 3468021.25
EU funding (EUR): 3468021.25
Participants: 4
Project status: SIGNED

Ammonia is one of the most important chemicals, but its production requires an energy intensive process, responsible for about 1-2% of total CO2 emissions worldwide. Ammonia is also potentially a formidable energy vector, with large hydrogen content, high energy volumetric density and, unlike H2, ease of liquefaction for storage. The main objective of TELEGRAM is to demonstrate, at the laboratory scale level, a complete green ammonia carbon–neutral energy cycle, based on electrochemical processes, enabling the use of ammonia as a green fuel. Achievement of this target requires the development of two key enabling technologies. The first is the electrochemical ammonia synthesis. This will be developed by adopting a multi-stage membrane reactor which, starting from air, water and renewable sources (sunlight or wind), will produce ammonia at temperature <100°C. Novel energy materials, such as high entropy alloys and nanostructured catalysts will be studied and implemented in the reactor. The objective is to reach performance values able to make the process effective for industrial exploitation, i.e. faradaic efficiency >50% and production rate of at least 10^-7 mol/s /cm². The second technology is the direct ammonia fuel cell (DAFC). For DAFC the best catalyst choice is platinum group metals (PGMs). Specific solutions will be developed in order to minimize or eliminate the PGMs achieving, operating below 100°C, a power density of at least 100 mW/cm² and chemical to electricity efficiency > 25%, with PGM loading < 0.05 mg/cm². The developed ammonia reactor, powered by renewables, and the DAFC will be coupled together to demonstrate the complete ammonia energy cycle at a laboratory scale. The objective is to achieve 95% of the combined efficiencies of ammonia generation and fuel cell. These results will contribute to establish an European innovation base on the two key enabling technologies and on novel catalysts, and to build a sustainable renewable energy system.

Keywords: energy conversion,collection and storage,energy vector,green ammonia,ammonia fuel cell
Breaking borders, Functional genetic screens of structural regulatory DNA elements (Breakborder)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2497000.0
EU funding (EUR): 2497000.0
Participants: 1
Project status: SIGNED

The human genome carries genetic information in two distinct forms: Transcribed genes and regulatory DNA elements (rDEs). rDEs control the magnitude and pattern of gene expression, and are indispensable for organismal development and cellular homeostasis. Nevertheless, while large-scale functional genetic screens greatly advanced our knowledge in studying mammalian genes, such tools to study rDEs were lacking, impeding scientific progress. Interestingly, recent advance in genome editing technologies has not only expanded the available screening toolbox to examine genes, but also opened up novel opportunities in studying rDEs. We distinguish two types of rDEs: Transcriptional rDEs that recruit transcription factors to enhancers, and structural rDEs that maintain chromatin 3D structure to insulate transcriptional activities, a feature postulated to be essential for gene expression regulation by enhancers. Recently, we developed a CRISPR strategy to target enhancers. We showed its scalability and effectivity in identifying potential oncogenic and tumour-suppressive enhancers. Here, we will exploit this line of research and develop novel strategies to target structural rDEs (e.g. insulators). By setting up functional genetic screens, we will identify key players in cell proliferation, differentiation, and survival, which are related to cancer development, metastasis induction, and acquired therapy resistance. We will validate key insulators and decipher underlying mechanisms of action that control phenotypes. In a parallel approach, we will analyse whole genome sequencing datasets of cancer to identify and characterize genetic aberrations occurring in the identified regions. Altogether, the outlined research plan forms a natural extension of our successful functional approaches to study gene regulation. Our results will setup the foundation to better understand principles of chromatin architecture in gene expression regulation in development and cancer.

Keywords: non coding genome,chromatin architecture,functional genetic screens,cancer
Twinning for Improving Capacity of Research in Multifunctional Nanosystems for Optronic Biosensing (TWINFUSYON)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Austria,Italy,France,Czechia
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 999718.75
EU funding (EUR): 999718.75
Participants: 4
Project status: CLOSED

The overarching aim of TWINFUSYON is to strengthen, to the highest European level, CEITEC scientific excellence and innovation capacity in nanosystems for a novel generation of label-free non-invasive optronic biosensing by harmonising integration of expertise in nanomaterials synthesis, characterisation at nanoscale, nanofabrication technologies, theory and modelling development, design of biosensors, which are the building blocks to innovate biosensing devices. To enhance CEITEC research capacity and improve staff’s research profile, TWINFUSYON establishes a platform around 4 pillars: -Science &Technology Pillar: Coordinating research on multifunctional nanomaterials to create a versatile label-free biosensing platform based on innovative ideas and advancement in the topics of: (A) 2D-TMD heterostructures (graphene, transition metal dichalcogenides)-based optronic biosensors (B) Plasmonic nanostructures-based enhanced SERS biosensors - Education Pillar: Supporting improvement in education and professional capacity, ensuring CEITEC regional leadership while moving towards the innovation- and intelligence-based economy - European Integration Pillar: Enhancing high-tech cooperation with industry and implementing best practices of twinning partners to improve technology innovation in optronic biosensing - Society Pillar: Raising awareness, disseminating information and promoting organisational practices to involve stakeholders in aspects of ethics, standardisation and technology transfer for exploiting nanosystems and biosensing devices. The expected impact of the TWINFUSYON multidisciplinary partnership, which includes CNR, University of Linz and CNRS, is an increase in CEITEC research cross-fertilisation, visibility, societal/regional responsiveness and in innovation potential for the most advanced topics of optronic biosensing that can be exploited in a number of important areas including food safety, security, life science, medicine and environmental monitoring

Keywords: nanomaterials,2d tmd materials,nanotechnologies,plasmonics,characterisations,optical spectroscopies,chemistry of surfaces,biophysics,bio functionalisation,biosensing
Development and application of ion-sensors for multi-analyte detection (VITAL-ISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2024-07-22
Duration (months): 36.0
Total project cost (EUR): 263768.64
EU funding (EUR): 263768.64
Participants: 2
Project status: TERMINATED

This project will investigate vital new approaches to preparation of ion sensors that will alleviate problems associated with chemical measurements in clinical chemistry and environmental monitoring. Two years of this fellowship will be spent in Australia and one year in Ireland, undergoing two-way transfers of knowledge. Secondments to industry relevant to ion sensor development and manufacture will be undertaken. Stable, robust sensor devices that employ new solid state contact materials incorporated within user-friendly microfluidic devices will be achieved. Such devices are needed to improve critical care and biomedical diagnostics as well as ensuring safe water around the world. The specific goals of this project are to synthesise a range of new redox materials that are designed as solid contacts in ion sensors, to evaluate the performance of such sensors in clinical and environmental settings, and to integrate such sensors into multi-channel microfluidic systems to achieve in-field robust measurements. The new sensor systems of this project will provide vital improvements in reliable ion sensing capabilities.

Keywords: chemical sensors,electroanalysis,redox materials
19th-Century European Picture-Books in Colour (PiCoBoo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-24
End date: 2021-07-13
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The PiCoBoo project aims to assess the significance of 19th-century European picture-books, printed in colour for children, as a catalyst for major cultural and social changes. From the 1830s, new techniques were developed that allowed to print colour in a cheaper, greater and more refined extent: for the first time, people – no matter their age, gender, social class, ethnicity, nationality – saw the world in colour. It is remarkable that this major revolution in visual culture had its birth in books for children. It is doubly remarkable that neither children’s book scholars nor book historians have investigated the genesis, development and effects of this major shift in print culture. We lack studies of how colour became prevalent in children’s books, expanded more widely through print and spread across national boundaries. PiCoBoo will draw new attention to this important chapter in the history of the book through publications, exhibitions and conferences. Adopting an object-based interdisciplinary approach, this will be the first detailed account of 19th-century colour picture-books for children: what they were, when, where and how they were made, who produced them and for whom, what their role in cultural, publishing and visual history and their long-term influence. In the absence of European aggregators of children’s books, PiCoBoo will build a network of collections of colour picture-books and, in the unreliability of collection and library catalogues, it will establish protocols for recognising and cataloguing them. PiCoBoo will be hosted by the Children’s Literature Unit at Newcastle University, UK, with a Secondment at the Victoria & Albert Museum, London, and in partnership with Seven Stories, the UK’s National Centre for Children’s Books. It is especially timely because only recently the Alderson Collection, the most significant gathering of British children’s books still in private hands, has been donated to Newcastle and made accessible to the public.

Keywords: children s book illustration and publishing,printing techniques and history,cheap print,art history,19th century books,cataloguing and library sciences,database systems
Stirling heat pump for high temperature industrial use (Highlift)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Finland,Norway,Norway,Sweden
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2019-01-01
End date: 2022-03-31
Duration (months): 39.0
Total project cost (EUR): 3364048.75
EU funding (EUR): 2439511.5
Participants: 6
Project status: CLOSED

Industry is the highest heat consuming sector, and its need for high temperature process heat is on the increase. However, 83% of industrial process heat is still supplied by inefficient and polluting fossil fuel boilers. The Highlift project will develop a next-generation high temperature heat pump (HTHP) based on an innovative 4-cylinder alpha configuration Stirling engine design. Highlift accepts low temperature (30´C) input water drawn from industrial waste heat recapture systems and use electrical energy to generate saturated steam at over 180´C. Such temperature lifts are not possible with any other HTHP today. The Highlift project optimises the industrial design via 1) increased system efficiency, 2) improved reliability, 3) 30% cut on production costs, 4) refined production quality control, and 5) improved Cloud-based operating system. We will pilot the near-market prototype at a single high-profile multinational industrial end user with high demands in terms of constant, intensive operation and high output temperature requirements. The project will simultaneously undertake a market maturation process including up- and downstream supply chain development, in-depth target market analyses, and validation of the business and commercialisation strategy. This will bring the HighLift technology to full commercial readiness at the end of the project. Over 25,000 hours of tests with industry since 2012 have shown that it is feasible to use Highlift to generate hot industrial process steam in an economic and environmentally sustainable way. Highlift reduces energy consumption to supply high temperature process heat by 50-70% and will cut industrial CO2 emissions when producing high temperature steam by 70-96%. Our planned commercial roll-out of 174 Highlift heat pumps by 2025 will save our customers a total of €134.2m, and reduce up to 65,600 tons of CO2 (eq) emissions.

Keywords: high temperature heat pump,industrial process heat,reversed stirling engine,saturated steam,industrial waste heat,chemicals industry,food and beverage industry,clean power,carbon emissions