Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Building a European strategic Research and Innovation Area in Direct Synergy with EU and International Initiatives for Pandemic Preparedness PLUS (BE READY PLUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Coordination and support actions
Countries involved: France,Spain,Italy,Austria,Belgium,Denmark,Germany,Luxembourg,Norway,Poland,Portugal,Sweden,Netherlands,Greece,Finland,Lithuania,Türkiye,Ireland,United Kingdom,Switzerland,Hungary
Call: Pandemic preparedness and response: Maintaining and enhancing the preparatory work for a co-funded European partnership for pandemic preparedness (HORIZON-HLTH-2024-DISEASE-17, 2024)
Start date: 2025-01-01
End date: 2025-12-31
Duration (months): 12.0
Total project cost (EUR): 1092480.0
EU funding (EUR): 1092479.5
Participants: 31
Project status: SIGNED

BE READY PLUS aims to extend and enhance the efforts initiated by BE READY in preparing for pandemic response across Europe. The primary objective is to establish a robust and coordinated European Partnership (EP) for pandemic preparedness, fostering strategic alignment among Member States, Associated Countries, and key stakeholders. This will be achieved through the following key pillars: 1) Paving the way for the future European Partnership: BE READY PLUS will provide the necessary administrative and organizational support to ensure a smooth transition to the EP. This includes drafting operational procedures, governance frameworks, preparing requirements to launch Joint Transnational Calls, and engaging key stakeholders to create a solid research and innovation framework. 2) Paving the way for pandemic preparedness: The Strategic Research and Innovation Agenda (SRIA) established by BE READY will be disseminated and updated to reflect new research needs and gaps. BE READY PLUS will also prepare the ground for ever-warm networks of clinical, study sites across Europe, ensuring rapid response capabilities for future health threats. 3) Maximizing the impact of BE READY PLUS: This pillar ensures comprehensive communication and dissemination activities, leveraging digital platforms while maintaining crucial engagements. It aims to engage a wide range of stakeholders, from scientific communities to policymakers and the public, to foster collaboration and increase awareness about pandemic preparedness. BE READY PLUS builds on the successful foundation of BE READY, expanding the consortium to 31 partners from 21 countries, by the addition of 10 new partners and 5 new countries. We will work in synergy with a broad range of European stakeholders and initiatives. Overall, BE READY PLUS will contribute to a more resilient Europe by preparing a detailed operational framework, fostering strategic coordination, and ensuring readiness for swift response to future health crises.

Keywords: networks,partnership,pandemic preparedness and response,health emergencies,sria,one health,ssh,alignment of research,transnational calls,ever warm clinical study sites,raising public awareness
From engineering to evolution of synthetic cells with RNA origami (ENSYNC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1749624.0
EU funding (EUR): 1749624.0
Participants: 1
Project status: SIGNED

Can we construct a cell from non-living matter? In search for answers, bottom-up synthetic biology has successfully encapsulated functional sets of biomolecules inside lipid vesicles, yet a “living” synthetic cell remains unattained. ENSYNC aims for a prototype of a synthetic cell that encompasses a fundamental characteristic of life, namely evolution. My past work shows that DNA origami can achieve custom-engineered synthetic cellular parts, but the mere encapsulation of preformed parts conflicts with the vision of a self-replicating and evolving synthetic cell. I here propose to produce and to replicate functional RNA origami structures inside of lipid vesicles (GUVs) by co-transcriptional folding from a DNA template. First, I will genetically encode an RNA nanopore and RNA origami structure which induces GUV division. The DNA template (“genotype”) will determine the GUVs’ permeability and their division rate (“phenotype”). This genotype-phenotype mapping is the basis for directed evolution of the rationally engineered RNA origami structures in the second step. In particular, I will aim for efficient GUV division in repeated cycles of genetic diversification and selection. In the third step, I will implement multiple growth and division cycles to enable continuous directed evolution. This will be achieved by system-level integration and laboratory automation of the directed evolution pipeline to iteratively reduce researcher intervention. Depending on externally applied selection pressures, continuous evolution will inevitably lead to the dominance of highly proliferating synthetic cells in mixed populations. ENSYNC provides fundamental insights into evolutionary processes as well as applicable RNA origami-based tools for nanopore sensing and as genetically encoded biophysical probes in cell biology. Overall, ENSYNC pushes the boundaries of bottom-up synthetic biology to the point where synthetic cells can be evolved towards a distinct goal in biotechnology.

Keywords: bottom up synthetic biology,rna origami,directed evolution,dna nanotechnology,synthetic cells,synthetic cell division,nanopores,giant unilamellar vesicles guvs,liposomes,lipid membranes,in vitro compartmentalization
Monitoring, Environmental Impact and Safety Assessment of UV Filters in Seafood (SafeSea)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Australia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-15
End date: 2029-02-14
Duration (months): 36.0
Total project cost (EUR): 309369.36
EU funding (EUR): 309369.36
Participants: 2
Project status: SIGNED

Ultraviolet (UV) filters, used in sunscreens and other consumer products, are effective at blocking UV radiation but can enter marine environments due to inadequate wastewater treatment and human activities. This contamination poses significant risks to marine ecosystems, especially in tourist-heavy coastal regions. Coastal biota, such as mussels and seaweeds, are exposed to these contaminants, leading to their accumulation in tissues and posing significant ecotoxicological risks, including endocrine disruption and DNA damage. Furthermore, these contaminants may enter the human diet through seafood consumption, posing substantial exposure risks. There is a critical need to understand the impact of UV filter contamination on marine ecosystems and human health, especially in Australia, where these compounds remain under-investigated. In response, the SAFESEA project will adopt a holistic strategic approach to monitor and assess the ecotoxicological risks associated with UV filter bioaccumulation in marine organisms along the southeast coast of Australia. The methodology includes metabolomic studies, functional analysis, and metabolic pathway assessments to establish correlations between contaminants and metabolites, while also considering spatial variation. The project will evaluate dietary intake and exposure risks from seafood consumption by comparing data from Australia with that of Mediterranean countries. By employing rigorous methodologies and interdisciplinary approaches, the SAFESEA project aims to provide significant insights into ecological and human exposure resulting from UV filter contamination in marine environments, and to advocate for the reduction of water pollution and the protection of marine ecosystems.

Keywords: uv filters,seafood,ecotoxicological impact,environmental monitoring,risk assessment
Sustainable and healthy food solutions: system dynamics and trade-offs (FLORA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1495428.0
EU funding (EUR): 1495428.0
Participants: 3
Project status: SIGNED

Food systems are crucial to end hunger, but also to mitigate and adapt to climate change, to protect and restore biodiversity, to ensure human health and well-being, to end poverty, and to support sustainable communities. While hunger has receded, food systems are causing increasingly severe damage to our environment and health. The FLORA project will contribute to a transformation of global agri-food production, trade, and consumption necessary to achieve sustainable and healthy food systems. The project will create essential evidence to identify and implement the shifts in practices and behaviours needed to effectively achieve this transformation, by (1) making a diagnosis of the integrated health and environmental outcomes of food systems globally, from the production and consumption perspectives, with innovative measures of sustainability, (2) identifying key threats and opportunities with system dynamics and complex network analyses, and (3) targeting and evaluating tailored solutions with an inter-disciplinary modelling framework. The project will enable the identification of most effective, targeted solutions by considering trade-offs, synergies, and dynamics of key food systems components. Global in scope, it sets the ambitious goal to overcome barriers in current approaches by taking a systemic approach and establishing a robust, interdisciplinary framework supported by empirical advancements to tackle complex food systems challenges. This innovative project builds on the PI’s excellent track record in leading interdisciplinary research focused on the global agri-food system and its environmental impacts.

Keywords: food systems
Learning Network for AI and Data-Powered Social Innovation and Co-Creation of Transformative Change (Data2Action)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Slovenia,Belgium,United Kingdom,Brazil,Germany,France,Portugal,Poland,Netherlands,Switzerland,United States,Greece,Ireland
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 2551168.8
EU funding (EUR): 2551168.8
Participants: 34
Project status: SIGNED

Data2Action will train 10 doctoral Fellows as the next generation of transdisciplinary social innovation leaders who are capable of ethically and responsibly developing state-of-the-art data science and artificial intelligence (AI) for social good. The network will bring together leading data science and AI researchers and experts with practitioners and experts in social innovation to conduct empirical research and cascading skill-building with the following objectives: Objective 1: Establish a research roadmap and framework grounded in empirical knowledge and best practices for data science/AI to power social innovation (Data/AI for Social Good). Objective 2: Demonstrate the potential and benefits across sectors of implementing social innovations powered by data science and AI through five demonstrator projects that showcase the impact on critical societal issues: Climate, Social justice, Democracy, and Health and Ageing. Objective 3: Build capacity, Data/AI tools and methods for social innovators and entrepreneurs through an integrated open cascade training programme. Objective 4: Create new career pathways for data science and AI dedicated to social innovation. Objective 5: Provide guidance and support for practice about data science and AI for social innovation to stakeholders who contribute to social innovation: policymakers, funders, and governmental organisations and to data science and AI technology development.

Keywords: data science,social enterprise,social economy,artificial intelligence,responsible innovation,health,ageing,climate,democracy
Interdisciplinary doctoral training on oligonucleotide-based therapies for myotonic dystrophy (ENTRY-DM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Spain,Italy,Netherlands,Germany,Poland,United States,United Kingdom,Sweden
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 3804513.94
EU funding (EUR): 3693326.4
Participants: 29
Project status: SIGNED

Rare diseases, though individually infrequent, collectively pose important challenges for patients, clinicians and researchers in terms of diagnostics, healthcare and treatment. Myotonic Dystrophy (DM), the most predominant inherited muscular dystrophy in adults, impacts 60,000-70,000 individuals in Europe. Its complex genetic and clinical variability result in a lack of robust genotype-phenotype correlations, which complicates the understanding of tissue-specific disease mechanisms, the development of effective therapies and the stratification of patients into well-defined clinical groups for clinical trial purposes. In recent years, Antisense Oligonucleotides (ASO) have emerged as promising therapeutics, notably in neuromuscular disorders. However, previous clinical trials in DM have failed due the reduced efficacy and bioavailability of the ASO tested. ENTRY-DM aims to train 14 DCs in translational research, through the combination of basic and clinical competencies across multiple disciplines, as well as strong soft and transferable skills. Our interdisciplinary network seeks to enhance scientific and technological knowledge, spanning from disease mechanisms, ASO design and delivery strategies, to clinical trial preparedness, using innovative multidisciplinary approaches and best practices. The consortium includes experts in DM research, bioengineering of model systems for preclinical drug screening, ASO chemistry, as well as clinical and neuropsychological assessment. Close collaborations with multi-sectoral partners will address the challenges in technology transfer, providing high-quality bench-to-bedside training to the next generation of researchers. Through these efforts, ENTRY-DM will catalyze ASO therapeutic development towards upcoming impeding clinical trials, establishing solid foundations for future clinical applications, increased investment and entrepreneurship ventures in the field of DM and other related diseases.

Keywords: myotonic dystrophy,neuromuscular disease,oligonucleotide therapy,in vitro 3d disease models,disease biomarkers,neuropsychological assessment of decision making
Scholars, Animals, Images, Geographies, and the Arts: De-exoticizing Eastern Europe in the Early Modern Period (SAIGA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Poland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2497775.0
EU funding (EUR): 2497775.0
Participants: 1
Project status: SIGNED

Building on Claude Lévi-Strauss’s oft-cited claim that “animals are good to think with,” SAIGA sets out to forge a zoological trail in the understanding of Eastern Europe between the sixteenth and late eighteenth centuries. Focusing on animal representations, the project will shed new light on the role of images in the production and transfer of knowledge. The project will highlight the region’s underrated contributions to the development of natural history by examining the overlooked Eastern European nodes in networks of scholars. By investigating various patterns of transmission of knowledge from East to West, this study will consider the vital role of Eastern informants, both trusted experts and unreliable amateurs. With animals as the primary object of investigation, the project will direct attention to the arduous processes of discovering Eastern European fauna. While some species had already been recorded by ancient authors (though seldom if ever seen), other species were only documented in the early modern period, turning Eastern Europe into a rewarding research opportunity for naturalists. Tracing the replication of images of Eastern European fauna, the project seeks to understand how early modern naturalists accounted for the discrepancies among ancient, medieval, and contemporaneous sources, and how their strategies of verification varied between the sixteenth and eighteenth centuries. Mapping this knowledge transfer onto the articulation of early modern geographies—which also attempted to make sense of the regions situated between Europe and Asia—the project promises to move the study of Eastern Europe beyond the paradigm of “demi-Orientalism,” which all too often imposes a modern othering lens onto the earlier past of the region. Finally, the project will foreground the role of the arts, above all various printmaking techniques, in projecting the image of the region as an environmental and cultural landscape defined and distinguished by its animals.

Keywords: eastern europe,early modern period,sarmatia,animal studies
Inertial effects on settling of microplastics in turbulent wavy flows (InMyWaves)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 224991.04
EU funding (EUR): 224991.04
Participants: 1
Project status: SIGNED

Millions of tons of plastic waste have been found in our oceans over the past 10 years, posing ingestion hazards to marine organisms and our food chain. These plastics enter the ocean either as microplastics (< 5 mm in size) or larger plastics which slowly disintegrate into smaller particles before sinking to the ocean bed due to polymer disintegration and biofouling. While past studies primarily focused on floating debris, the settling dynamics of microplastics below waves, which are turbulent in nature, are not well known. Although models exist and this problem has been looked at, due to the challenges in simulating finite-size particles, point-particle assumptions are generally applied in the analytical and numerical modeling of particle-laden flow. This neglects the effects of particle inertia. Moreover, the combined influence of waves and turbulence on particles of various shapes and sizes has never been coupled. This is a major deficiency in the state-of-the-art. Hence, in this work, I will focus on particle inertia, free stream turbulence, and the combined effects of waves, to pinpoint the key parameters that govern the particle motion in wavy turbulent flows. To represent the microplastics, various modeled particles will be fabricated and tested first in a quiescent flow. These particles will then be released into the large-scale water channel facility at NTNU subjected to free stream turbulence and waves. Two series of experiments will be conducted using advanced flow and wave imaging techniques to track the particle, turbulence, and wave motions simultaneously. The results of this work will lead to improved models for simulating the transport of plastic waste and pollutants in rivers and oceanic flows by incorporating the dominant parameters that have previously been neglected. It will also bridge the understanding between both oceanic and turbulence communities on the transport of microplastics.

Keywords: particle laden flow,free stream turbulence,waves,particle inertia,particle turbulence interactions,particle turbulence wave interactions
Satellite-based services to support sustainable land use practices under the European Green Deal. (GreenEO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Norway,Netherlands,France,Denmark,Portugal,Spain,Greece,Germany
Call: Develop innovative applications to support the European Green Deal, building on meteorological satellite data (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 3993673.75
EU funding (EUR): 3993673.75
Participants: 11
Project status: SIGNED

The main objective of GreenEO is to provide improved satellite-based environmental information to support sustainable nature protection practices across four competing land-use areas: cities, agricultural areas, forests, and ecosystems. Through combined exploitation of new Earth Observation products, digital infrastructure, and atmospheric and land surface models using machine learning and data assimilation, GreenEO will provide environmental information and stakeholder engagement practices to support the implementation of the Zero Pollution (ZP) and Biodiversity aspects of the European Green Deal (EGD). The project will serve as a proof-of-concept to enhance specific services provided by Copernicus and EUMETSAT in support of the EGD implementation. GreenEO aims to support the transition towards more sustainable land use practices in Europe and proposes a transformative governance system, relying on a data value chain enhanced with active stakeholder engagement and co-creation. The value chain proposes the uptake of satellite data, integrated in a modelling development chain and followed by value creation modelling applications. In cities, GreenEO will develop three satellite-based approaches of high-resolution urban-scale air quality maps to engage relevant stakeholders to support the ZP strategies. For agriculture, GreenEO will address impacts on nitrogen emissions, deposition, and biodiversity. It will create satellite-based high-resolution emission inventories, deposition, critical load exceedance maps, and identify areas with high recovery potential. GreenEO will develop a forest fire service that will revolutionize the monitoring of wildfires over Europe. GreenEO will create novel ecosystem monitoring indicators such as city greening indicators, ecosystem area and condition indicators. GreenEO will advance seamless climate-weather and environmental services in Europe, by proactive links to EUMETSAT, WMO, the Copernicus Services, EEA and EU Missions.

Keywords: zero pollution strategies,forest fires risk management,biodiversity recovery services,european green deal governance