Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The European Union's Support to the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) (EU4IPBES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Coordination and support actions
Countries involved: Kenya
Call: Dedicated support for the IPBES secretariat (HORIZON-CL6-OA01-2022-IBA, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 5000000.0
EU funding (EUR): 5000000.0
Participants: 1
Project status: SIGNED

The overall objective for this action is to support the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) and the implementation of its rolling work programme up to 2030, as set out in annex I to decision IPBES-7/1. The IPBES rolling work programme up to 2030 aims to advance the achievement of the overall objective of IPBES, which is to strengthen the science-policy interface for biodiversity and ecosystem services for the conservation and sustainable use of biodiversity, long-term human well-being and sustainable development.

Keywords: ipbes biodiversity science policy interface
EXploring Photoinduced Enzyme pRomIscuity in the Glucose-Methanol-Choline oxidoreductase family to dEvelop New phoTocAtaLysts (EXPERIMENTAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-15
End date: 2025-08-14
Duration (months): 36.0
Total project cost (EUR): 300441.6
EU funding (EUR): 300441.6
Participants: 3
Project status: CLOSED

Photoenzymes are rare biocatalysts that use the energy contained in photons to perform chemical reactions. To date, only one natural photocatalyst is known to have biotechnological applications; the Fatty Acid Photodecarboxylase (FAP), allowing the production of hydrocarbons from fatty acids. FAP belongs to a superfamily of enzymes called Glucose Methanol oxidoreductases (GMCox). Still, the FAP group is the only one known to perform photochemistry despite the high degree of structural similarity and presence of a photosensitive cofactor, Flavine Adenine Dinucleotide (FAD), in all GMCox. We reason that the GMCox family could have a latent photochemical function, and we would like to exploit it. Therefore, the objective of this project is to EXplore Photoinduced Enzyme pRomIscuity in the Glucose-Methanol-Choline oxidoreductase family to dEvelop New phoTocAtaLysts (EXPERIMENTAL). To this end, we will first test the photoinduced substrate promiscuity with different GMCox using an “accelerated serendipity” approach. In a second step, we will optimize the newly discovered photoenzymatic activity by directed evolution. Finally, the enzymatic mechanism will be characterized using different biophysics approaches, ranging from time-resolved spectroscopy to serial femtosecond crystallography. This project is inherently interdisciplinary, combining chemistry, biochemistry and biophysics to develop new photocatalysts for biotechnological purposes. For fundamental research these new photoenzymes will be an opportunity allowing the study of ultrafast processes that occur during catalysis and can only be observed with light-dependent enzymes such as electron and/or proton transfer, bond breaking ect. In fine, the goals of EXPERIMENTAL are to provide a better appreciation of the capabilities of enzymes and meet the demand for new and sustainable methods in organic synthesis by providing with the GMCox family a toolbox for the design of new light-driven reactions.

Keywords: photoenzymes,radical chemistry,biocatalysis,directed evolution,flavoenzymes
In vivo Immunofluorescence-Optical Coherence Tomography (Immuno-OCT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

Current clinical medicine relies on MRI and CT for structural imaging, and immuno-PET/SPECT for molecular specificity. The combination of structural imaging and molecular specific imaging provides detailed information about expression of proteins and cell surface receptors in vivo in humans. PET-CT/MRI has become an essential component of personalized medicine. However, the resolution of MRI/CT is just under a millimeter, while the resolution of PET is limited to about 2-10 millimeters, insufficient for early disease detection. Moreover, PET is associated with radiation burden of ligands labeled with a radiotracer and can image only one labeled ligand at a time. What is missing is the ability to image in vivo with much higher resolution, and to image multiple molecular targets and molecular interactions simultaneously. I propose to develop the optical equivalent of PET- CT/MRI with a 10 to 100 fold better resolution. To reach this goal I will integrate three-dimensional endoscopic Optical Coherence Tomography (OCT) for structural information with depth resolved imaging of fluorescently labeled monoclonal antibodies for molecular specificity. To image the hollow organs accessible by endoscopy, I will develop the immuno-OCT technology integrated with miniature motorized catheters and the multi-fiber detection technology for depth resolved fluorescence determination for endoscopic immuno-OCT in catheters as small as 1.5 mm diameter. I will focus on esophageal cancer and lung disease. The proposed research has a much broader impact, creating a platform to study in detail therapy-tissue interactions longitudinally in vivo in patients, providing in vivo information approaching immunohistochemistry analysis. This approach will revolutionize the diagnosis and treatment of patients with a resolution approaching immunohistology at high speed over large volumes using minimally invasive technologies.

Keywords: medical imaging optical coherence tomography molecular contrast minimally invasive endoscopy fluorescent markers
Coupling morphogen dynamics with mechanics in the control of form and pattern (DYNAMORPH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Embryogenesis entails both the generation of cell type diversity and large-scale morphogenetic movements sculpting the forming body axes. How patterning and morphogenesis are each individually controlled is increasingly understood, yet how these fundamental processes are coordinated remains an open question in biology. My recent work in zebrafish gastrulation, a crucial developmental stage where the germ layers are specified and shaped, provided a conceptual framework for how patterning and morphogenesis can be coupled by morphogen signalling. However, how a small set of highly conserved morphogens mechanistically controls a striking diversity of biological functions across many developmental systems remains unclear, especially as little is known on how morphogen signalling encodes the mechanical forces organizing morphogenesis. We hypothesize that examining the multiscale interplay between morphogen dynamics and mechanics will provide the missing link to understand how the emergence of pattern and form are coordinated by a handful of morphogens. Using both zebrafish embryos and human 2D gastruloids, we aim to uncover: 1. How the dynamics of morphogen signalling encodes the mechanical properties organizing morphogenesis. 2. How cell and tissue mechanics, in turn, modulate morphogen signalling dynamics and robust patterning. 3. How cells decode dynamical mechanochemical inputs to instruct cell fate and patterning. Towards these goals, we will combine our expertise in biophysics and developmental biology with recent advances in live-cell signalling reporters, optogenetics, biophysical tools and gastruloid models to quantitatively understand the design principles and molecular effectors of the cross-talk between morphogen dynamics and mechanics. This will generate novel insights relevant beyond developmental biology, with direct implications for engineering of organoid technologies, regenerative medicine and our understanding of the evolution of form and pattern.

Keywords: morphogen,signalling dynamics,cell and tissue mechanics,morphogenesis,patterning,gastrulation
Transforming into a sustainable European pharmaceutical sector (TransPharm)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Belgium,Finland,Netherlands,Germany,United Kingdom,Ireland,France,Latvia
Call: Green pharmaceuticals (HORIZON-HLTH-2021-IND-07, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 8077100.74
EU funding (EUR): 8039600.24
Participants: 12
Project status: SIGNED

TransPharm two-track approach focusses on the one hand on the compounds itself by identifying greener and more sustainable-by-design Active Pharmaceutical Ingredients (APIs) and on the other hand reducing the environmental impact and resilience of the manufacturing process by optimizing the synthesis route of new APIs in continuous flow and by proposing greener alternative solvents. The aim of the project is to (i) analyse and predict flow behaviour and environmental biodegradability of APIs and their synthesis pathways; (ii) identify greener and more sustainable alternatives to pharmaceutical products / APIs of concern; (iii) reduce the footprint and create important shortcuts in synthetic schemes of APIs; and (iv) assess the sustainability of pharmaceuticals over their entire life cycle. To reach the envisaged aims, the project will deliver four toolboxes (consisting of digital tools and guidelines) for the development of greener pharmaceutical products and APIs. These toolboxes will be used to (v) assess the potential to move towards the transition to greener, more agile pharmaceutical production. In addition, TransPharm will elaborate on the business case for sustainable pharmaceutical products or APIs and what is needed to bring them to the market. The project will also make sure that (vi) key project results and knowledge are properly transferred towards targeted stakeholders. TransPharm?s outcome contribute to a Europe, that is self-sufficient by reducing dependence on API production in third countries; making the EU healthcare industry more competitive, sustainable and reliable, ensuring timely supply of essential medicines from particularly complex or critical supply and distribution chains and positioning EU as a leader in innovative technologies.

Keywords: active pharmaceutical ingredient,benign by design,biodegradability,flow chemistry,artificial intelligence,predictive tool,integrated sustainability assessment
Use of extremophile Helianthus species to mitigate climate change impact on feedstock and ecosystem services provided by sunflower (HelEx)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Research and Innovation actions
Countries involved: France,Austria,United States,Canada,Serbia,Netherlands,Germany,Poland,Romania
Call: Exploring extreme environments: novel adaptation strategies at molecular level for bio-based innovation (HORIZON-CL6-2022-CIRCBIO-02-two-stage, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 5184372.5
EU funding (EUR): 4997682.5
Participants: 18
Project status: SIGNED

Climate-resilient sunflower crops can help to reduce the EU dependency on imports of vegetable oils and proteins shifting towards sustainable alternatives, to mitigate the impact of agricultural production on water use and greenhouse gas emissions, to grow resources for pollinators, and to promote biodiversity. HelEx will generate the knowledge and use innovative tools to accelerate the breeding of sunflower varieties adapted to extreme drought and heat stresses, while improving their environmental impact and assessing their socio-economic value of the resulting innovations along the value chains. HelEx will thereby consider two related groups of traits increasingly impacted by climate change, i.e. the eco-systemic service to pollinators and seed quality. For this, HelEx brings together scientists, SMEs, and industries representing an international consortium of experts in sunflower ecology, physiology and genomics; plant biotechnology and breeding; pollinator biology and ecology; environmental impact assessment and feedstock processing; and socioeconomic assessment at different scales. This HelEx multi-disciplinary consortium will explore the genetic and molecular processes involved in tolerance to drought and heat in wild extremophile Helianthus species, and identify favorable wild alleles introgressed into cultivated sunflower, for seed quality and pollinator attractiveness resilience (WP1). These processes will be transfered using classical marker-assisted selection and innovative genome editing approaches (WP2), and the environmental and biodiversity impact of these new climate-smart sunflowers assessed (WP3). HelEx will investigate the socio-economic impact and benefits in relevant value chains for different feedstock (WP4). Our communication strategy (WP5) will engage a variety of societal stakeholders to ensure feedback and enhance project progress and outcomes, and make transparent the broader dimensions of plant biotechnology, biodiversity, and benefit sharing

Keywords: pollination,climate change,agroecology
EuroPean Training NetwoRks to TArget DAMPs and NETs: novel apprOaches in pRecision SepsIs pAtieNt care (PRAETORIAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,France,Germany,Sweden,Spain,Switzerland,Belgium,Norway
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2726568.0
EU funding (EUR): 2726568.0
Participants: 18
Project status: SIGNED

Sepsis remains one of the major challenges for societies worldwide, causing an estimated 7-9 million deaths every year. It is the leading cause of death at intensive care units in the EU. This high mortality persists because at present methods for timely diagnosis are lacking and no effective therapy is available. Therefore, there is a clear and urgent medical need to provide novel diagnostics and therapeutics for use in sepsis. The PRAETORIAN Doctoral Network has created a doctorate programme to deliver innovative training on preclinical and clinical science, business- and entrepreneurial aspects, intellectual properties and more, covering multiple aspects of the drug discovery and development process. This programme is unique as it will deliver a new generation of young scientists, each Doctoral Candidates (DCs), who will collaboratively work to develop novel approaches in precision sepsis patient care providing new diagnostics and therapeutics to answer to an urgent unmet clinical need. Recent insights have indicated a pivotal role for neutrophil activation and so-called damage associated patterns in the initiation and propagation of sepsis. However a comprehensive view on how these processes cause the onset of sepsis remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic and therapeutic solutions. PRAETORIAN was designed to address this urgent need by bringing together specialists from academia and industry to shape a new generation of entrepreneurial scientists who have skills, expertise and knowhow to further our understanding of sepsis pathophysiology into tangible and effective solutions for novel diagnosis and therapy.

Keywords: sepsis,septic shock,organ failure,netosis,neutrophil activation,damps,clinical diagnosis,theranostics,precision medicine
Markets and Mobility: How Employers Structure Economic Opportunity (MaMo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1499394.0
EU funding (EUR): 1499394.0
Participants: 1
Project status: SIGNED

Intergenerational mobility, measuring the ability to achieve economic success regardless of family background, is a critical reflection of a society’s commitment to equality of opportunity. Rising income inequality has raised concerns about the potential erosion of upward mobility. While education has traditionally been viewed as the path to mobility, its transformative power is facing challenges in a rapidly evolving job market. This project reorients the focus of intergenerational mobility research by highlighting the labor market as an arena for the reproduction of advantage. It employs a comparative approach, using administrative data from four countries: Sweden, Austria, England, and the United States. It also incorporates evidence from a broader set of nations through cross-national surveys, longitudinal household surveys, labor force surveys, secondary data, and digital trace data. The project employs cutting-edge empirical methods, including quasi-experimental designs, event studies, within-family comparisons, decomposition analyses, counterfactual simulations, and diagnostic checks to rigorously assess the extent of inequalities in the labor market. The research investigates how family background influences the sorting of individuals to employers and workplaces, accounting for education and occupation, and explores variations in career progression within and between employers. It comprehensively catalogues and assesses mechanisms shaping workplace inequality, contributing to the development of social closure theory. Additionally, the project evaluates intervention strategies, encompassing both employer practices and government actions, to promote fair opportunity in the labor market.

Keywords: economic mobility,income mobility,intergenerational mobility,inequality,social stratification
First European plant for the production of high characteristic biobased ALkanes for Beauty and Aeronautics fast growing markets (AL4BA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

AL4BA aims to bring to the market GBE’s unique technology offering a biobased substitution to the fossil-based version of the irreplaceable building block molecule Isobutene (IBN) and its high characteristics alcanes derivatives. This satisfies market traction both in cosmetics and Sustainable Aviation Fuels (SAFs) industry due to i) growing consumers demand and ii) changes in regulation. GBE will: 1) Continuously adapt its process to alternative sugars sources (e.g beet/starch, wood, wastepaper); 2) Optimize the bacterial strain production performances and the fermentation process to achieve further performance increase and reduce costs; 4) Optimize purification- and oligomerization/hydrogenation processes for bio-IBN conversion into high-value alcanes derivatives on an industrial scale; 5) Scale-up and perform feasibility studies comprising ISBL and OSBL units; 6) Perform construction studies for permitting and construction of an industrial plant; 7) Industrialize in >2 use-cases (cosmetics and SAF markets). Our disruptive innovation is the implementation of a unique artificial metabolic pathway in E.coli bacterial strain to produce bio-IBN, through fermentation of polysaccharide (sugars) containing streams from vegetal biomass. This pathway enables the world’s first ever fermentation process to gaseous bio-IBN, leading to major productivity improvements compared to current fermentation liquid processes. AL4BA will lead to: 1) Less GHG emissions as, thanks to its renewability, the carbon footprint of bio-IBN is low compared to the fossil-based version; 2) Highest quality solution to the green transition of IBN-derived-markets and satisfaction of the needs in natural formulas: NO compromise; 3) Maintaining and developing EU's economic and industrial sovereignty, by offering EU-produced bio-based alternatives to high value-added fossil-based platform molecules. Thus, AL4BA is key for the green transition of strongly demanding cosmetics, fuel and chemical markets.

Keywords: bio based isobutene,green chemistry,idd,idh,green transition,cosmetics,sustainable aviation fuels