Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LAFERIA - LAndscape FEatures Reintroduction in Intensive Agricultural land (LAFERIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Portugal,Bulgaria,Netherlands,Sweden,Belgium,Finland,Germany
Call: Reintroduction of landscape features in intensive agricultural areas (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4998576.25
EU funding (EUR): 4998576.25
Participants: 13
Project status: SIGNED

Agricultural intensification in EU farmland led to the loss of landscape features (LF) which provide ecosystem services (ES) and support for biodiversity. To tackle this, the EU Biodiversity Strategy for 2030 aims to increase the prevalence of LF to 10% of the agricultural area, but there are several technical, administrative, economic and social barriers to achieve this. The overall goal of LAFERIA is to identify the key factors that can promote the reintroduction of LF in intensive agricultural areas, and develop strategies to overcome key barriers to achieving the EU objective. Specific objectives include: (i) Quantify LF coverage and connectivity across different agricultural systems; (ii) Establish a comprehensive picture of the benefits and costs of LF for biodiversity, ES, climate change adaptation, yields, incomes, and society at large; (iii) Explore the drivers and challenges for the reintroduction of LF; (iv) Develop strategies and business models to reintroduce LF. The research plan is organised around three major thematic blocks: A first block focuses on environmental sciences, and addresses the current prevalence of LF across distinct agricultural systems in the EU, their importance for ecological connectivity, and their potential for biodiversity and ecosystem benefits. A second block builds on social sciences, and focuses on the key factors which may lead to the reintroduction of LF in areas of intensive agriculture, through a co-learning process with stakeholders, analysing factors of success and failure in existing initiatives, complemented with detailed research at regional (case study) level. In a final block we will translate the results into the design and development of strategies, encompassing the identification of priority regions and agricultural systems to reintroduce LF, the maximisation of the biodiversity and ES potential from LF, and the development of policy tools, business models and market-based solutions taking advantage of LF.
Subduing Self-discharge of All-solid-state supercapacitors by a novel hybrid Solid Polymer Electrolyte with layered inorganic nanofiller (SASPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Finland,Hungary
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-11-30
Duration (months): 28.0
Total project cost (EUR): 235938.48
EU funding (EUR): 235938.48
Participants: 2
Project status: CLOSED

The challenge taken worldwide in achieving a global climate-neutral society fasten the transition from fossil fuel to renewable energy and increasing the demand for energy storage systems (ESS) due to the intermittency of renewable energy sources. Supercapacitors (SC), especially hybrid supercapacitors, are a promising technology for powering hybrids, electric cars, or micro-grids, owing to many exciting advantages over batteries concerning specific power and cycle life. However, some research challenges such as high self-discharge, high production cost, and safety concerns impede market uptake. So the development of efficient, cost-effective SC technology with extremely low self-discharge, high energy and power density is significant. The SASPE aims at developing an all solid-state supercapacitor and build a novel strategy to reduce its self-discharge by applying modified solid polymer electrolyte with layered inorganic materials. Notably, SASPE will introduce a novel hybrid solid polymer electrolyte (SPE) with high ionic conductivity that can reduce the self-discharge of SCs, which will be prepared by a simple, environmentally benign, and cost-effective method. The SASPE will guarantee SC's safe operation by using modified SPE with high mechanical strength. SASPE also offers 2D hybrid binder-free electrodes with promising electrochemical performance such as specific capacitance, energy density, and power density. The project will connect the physical properties of inorganic materials with their electrochemical properties by using a nanofiller/matrix synthesis approach and in-depth physicochemical and electrochemical characterization techniques. SASPE will bring novel hybrid SPE along with high capacitance electrode materials and will make a solution for problems faced in current SC technology. The project will play a vital role in the electric vehicle industry by providing essential research progress in SC technology, which will help attain a green environment.

Keywords: energy storage devices,self discharge,all solid state supercapacitors,hybrid solid polymer electrolytes
Translating Tudor domain splicing inhibitors for oncological applications (ONCO-SPLICE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In our effort to characterize metabolic activities in the cell’s nucleus, we discovered that the understudied Tudor domain protein SMNDC1 controls the repression of insulin in pancreatic alpha cells through its role as a splicing modulator. Based on this finding, we developed the first selective SMNDC1 Tudor domain inhibitors, for which we observe interesting preliminary data on insulin induction in primary human pancreatic islets. However, as a pan-essential gene expressed in most tissues, SMNDC1 is not an ideal therapeutic target in diabetes, where exceptionally high safety margins are required. Interestingly, independent findings published in a preprint established a role for SMNDC1 in cancer. These data show that SMNDC1 controls splicing of the ERK1 exon that bears the phosphorylation signal mediating RAS/RAF/MEK/ERK signaling. A significant fraction of ovarian and pancreatic carcinomas harbor SMNDC1 amplifications, and cells derived from these tumors depend on SMNDC1 both in vitro and in xenograft models. We here propose to evaluate the potential of our SMNDC1 inhibitors for cancer therapy. Experimentally, we will test these compounds in the ERK1 splicing dependent models in collaboration with the groups that described these findings, and we will profile their antiproliferative effects against a panel of >900 cancer cell lines. In parallel, we will conduct detailed analysis on the chemical scaffolds we discovered and develop a medicinal chemistry proposal to expand the scope of the filed patent application. Additionally, we will commission analyses for an optimal translation pathway of these compounds to the clinic, aiming an ideal positioning for certain cancer subtypes based on market size, competitive situation, clinical needs and trial design opportunities. Finally, we will develop a plan for the further translation of our discoveries, ideally by foundation of a new spin-off company following successful completion of the ONCO-SPLICE project.
Underlying models for the European DIgital Twin Ocean - EDITO-Model Lab (EDITO-Model Lab)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: France,Italy,Netherlands,Denmark,Germany,Spain,Norway,Portugal
Call: Underlying models for the European Digital Twin Ocean (HORIZON-MISS-2021-OCEAN-05, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 6997721.25
EU funding (EUR): 6997721.25
Participants: 14
Project status: SIGNED

EDITO-Model Lab will prepare the next generation of ocean models, complementary to Copernicus Marine Service to be integrated into the EU public infrastructure of the European Digital Twin Ocean (EDITO) that will ensure access to required input and validation data (from EMODnet, EuroGOOS, ECMWF, Copernicus Services and Sentinels satellite observations) and to high-performance and distributed computing facilities (from EuroHPC for HPC and other cloud computing resources) and that will be consolidated under developments of Destination Earth (DestinE). The objective is to make ocean knowledge available to citizens, entrepreneurs, policymakers, decision-makers and scientific experts alike, thus enabling them to become partners in knowledge generation, explore desirable futures and develop ocean management scenarios (and assemble their own twins), with the overarching goal of ensuring a safe, healthy and productive ocean. As an interactive and user driven initiative, EDITO-Model Lab will deliver a Virtual Ocean Model Lab (VOML) including (1) a core model suite including global high-resolution models and coastal configurations, (2) downstream user toolkits and (3) a developer’s toolkit for a sustainable ocean. The VOML will be an interactive and co-development environment to operate models. EDITO core model suite will be based on modelling and simulation software, artificial intelligence (AI) algorithms and specialised tools to form a new service capacity for accessing, manipulating, analysing and understanding marine information. Intermediate and downstream stakeholders will find digital tools, data and information for ‘focus applications’ (FA) that refer to the Mission Ocean Lighthouses (MOLs) and the sustainable Blue economy, including ‘what-if scenarios’ to find solutions to natural and man-induced hazards. EDITO-Model Lab will be delivered in 36 months by a consortium of 14 authoritative partners, covering ocean knowledge, modelling and technological expertise.

Keywords: ocean modelling,downscaling from global ocean to coastal,what il scenarios,artificial intelligence,emulators,hybrid models,virtual research environment
The Shrinking Stock Market, Investibility, and Creative Destruction (Investibility)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 2489025.0
EU funding (EUR): 2489025.0
Participants: 1
Project status: SIGNED

There are ever fewer listed firms in the U.S. and Europe, and listed firms produce an ever shrinking share of innovation. Over the past 25 years, the number of firms listed on a stock exchange has dropped by 41% in the U.S. and 55% in Europe. At the same time, listed firms account for a shrinking share of the highly disruptive inventions that have the most potential to boost productivity and growth. In the U.S., for example, listed firms account for only 8% of the most ground-breaking patents today, down from a peak of 34% in 1969. These two mega trends combine to make an ever increasing share of innovation “uninvestible” for most individuals who, owing to investor-protection rules, are barred from investing in unlisted firms. The objective of my project is to study the economic consequences of this increasing wedge in access to the financial rewards of breakthroughs in science and technology between “the few” and “the many.” Disruptive innovation creates winners and losers. Workers and savers can, in principle, hedge against the risk of losing their jobs or savings due to "creative destruction" by investing in the winners. Whether everyone or only the few can hedge depends on the extent to which disruptive innovation is publicly investible. I will measure the investibility of disruptive innovation over the period 1841 to today, taking into account that a disruptive innovation that is born private can become publicly investible as its creator goes public, is acquired by a listed firm, or sells the patent to a listed firm. Armed with this measure of risk-spanning, I will investigate how the economy-wide cost of capital is affected when limited investibility results in an unequal sharing of the benefits of disruptive innovation between the wealthy and the many. Finally, I will test if differential access to high-expected-return investment opportunities as more and more economic activity takes place in private markets can help explain the rise in wealth inequality.
The world´s most energy efficient Industrial Air Compressor (Airon)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 3534220.8
EU funding (EUR): 2473954.56
Participants: 1
Project status: SIGNED

70% of all industrial sectors rely on compressed air for their daily operations. Compressed air production accounts for 10% of global industrial electricity consumption, corresponding to substantial carbon dioxide emissions. The production of compressed air with the conventional screw and turbo compressors is costly and unsustainable. Enairon air compressor technology addresses this inefficiency by introducing the first fluid type compressor design. Our patent-based compressor is a game-changer, empowering customers to cut electricity expenses by 37%, a persuasive argument in a sector where electricity constitutes 80-90% of a compressor's lifecycle cost. This translates into multimillion-euro savings and a significant decrease in CO2 emissions. Additionally, our compressor is simple and robust, ensuring heightened reliability, decreased maintenance requirements, and an extended lifespan. Our solution has been demonstrated in a relevant environment at pilot customer Stora Enso Paper AB dedicated in the Pulp and Paper Industry (TRL 6). We target a lucrative market opportunity, estimating a TAM of €30.31 billion by 2030 in the stationary segment. With a modest but significant 3.6% estimated total market share by 2030, we estimated revenues of more than €100 million, indicating the sale of about 87 compressor units across European and Asian markets. We request €2.5 million of EIC Accelerator grant, this will propel Enairon towards market entry with the first series of 400kW compressors, a tenfold increase in air volume from our current prototype, within two years. With a clear path to revolutionizing compressed air production, Enairon stands at the forefront of sustainable industrial solutions, ready to make a lasting impact on energy efficiency, environmental sustainability, and global industry standards.

Keywords: compressed air,industrial electricity consumption,sustainable technology,fluid type compressor
Cytokine inhibitors as immuno-therapeutics in cancer (Isunakinra)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Solid cancers represent a significant burden to the healthcare system despite years of progress in cancer therapeutics (90% of adult cancers). Notably, immune checkpoint inhibitors (ICI) represent a recent game changer in treatment, yet many cancer patients respond poorly to them -in part- because of persistent inflammatory signals in the cancer microenvironment. By developing potent and safe cytokine inhibitors at lower cost, Buzzard aims to improve treatment outcomes for solid cancers thereby improving patient survival and quality of life while reducing the economic burden of cancer in the EU and rest of world. We will start by developing the first clinically approved IL-1 inhibitor for cancer, Isunakinra, which binds the IL-1R1 receptor with an affinity 85x the best inhibitor on the market. In a Phase I clinical trial on 12 patients with a variety of solid cancers, Isunakinra was shown to be safe and well-tolerated when used in conjunction with a PD-1 inhibitor, while reducing the adverse inflammatory effects and pain typically associated with ICIs alone. Furthermore, at least 4 patients showed improved clinical outcomes, including a patient with colorectal cancer that showed near complete response 2+ years onwards. With the help of the EIC we will move into Phase II trials to test Isunakinra’s efficacy in 3 solid tumors types, namely colorectal cancer, HR+ and triple negative breast cancer. The ultimate goal being to licence Isunakinra to a Big Pharma company that will take the drug through Phase III trials, and eventually to market as the first approved IL-1 inhibitor for the treatment of solid cancers when used alone or in combination with ICIs. We estimate the global market for drugs like Isunakinra to be >€150 BIL in 2031 alone.

Keywords: immunotherapy inflammatory cancer colorectal cancer breast cancer il 1 inhibitor
Controllable stimulation and Advanced brain models for Enhancing Rehabilitation from Unconscious States (CAERUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

Disorders of consciousness (DoC) such as coma, and unresponsive wakefulness syndrome, affect individuals, their families, and society. Every year, 2.5 million people suffer from DoC caused by traumatic brain injury, and up to 80% die from premature interruption of life-supporting therapies. It is estimated that 25% of these patients could be conscious even without observable behavioral responses. Medical practitioners today can use brain stimulation as a means to assess the presence of consciousness and facilitate recovery. However, the high variability in brain stimulation effects challenges effective diagnosis, prognosis, and treatment. The absence of guiding principles leaves us with empirical decisions about where, how, and when to stimulate. CAERUS is an innovative initiative that aims to enhance consciousness readout and rehabilitation strategies by designing a new and more controllable stimulation protocol. Synergizing my profile as a theoretical physicist and neuroscientist, with the excellence of the host supervisor Prof. Deco in the field of computational neuroscience, and the secondment supervisor Prof. Massimini in the neurophysiology of consciousness, CAERUS will bridge the gap between theory and bedside applications. By establishing a theory-driven approach, I will characterize the principal sources of variability of stimulus effects, and provide a blueprint for precisely identifying where, how, and when it is more convenient to stimulate. Exploiting the predictive power of advanced brain models, I will test in silico a circuit-level stimulation protocol, that is expected to significantly reduce the variability of stimulus effects. Finally, I will validate the enhanced controllability of the new stimulation protocol in experimental tests in the laboratory. CAERUS's interdisciplinary approach and cutting-edge technology will pave the way for a novel strategy to stimulate the brain, aiming to translate our findings into tangible clinical applications.

Keywords: disorders of consciousness,consciousness readout,tms stimulation,state dependent brain stimulation,whole brain models,experimental validation
Repopulating European left-behind areas through international roots migration (RepEU-Mig)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

Due to the demographic challenges faced by many non-metropolitan areas across Europe, several national, regional, and local governments are promoting policies to attract immigrants with ancestral ties to these places. RepEU-Mig’s main goal is to understand the role of these policies in defying the demographic decline. While their outcomes are sometimes assessed through the evolution of socioeconomic indicators in the places of implementation, little is known about how these policies operate transnationally and how beneficiaries perceive their integration into left-behind places. RepEU-Mig addresses these gaps by comparing recent initiatives in Spain and Italy through an innovative approach that combines multi-level policy and governance analysis with an ethnographic study of the integration experiences of descendants born in Argentina. The objectives are: 1) to analyze and compare the legal content and the narratives that justify contemporary initiatives to attract immigrants with ancestral ties to left-behind places; 2) to examine the process of transnational promotion and implementation of these policies, including the role of various intermediate actors in origin and destination; 3) to better understand individual motivations and their interaction with structural factors that either help or hinder these newcomers’ integration. RepEU-Mig addresses the Key Strategic Orientation D of the Horizon Europe Work Programme 2023-2025, "Creating a more resilient, inclusive and democratic European society". The major expected outcomes are: 1) to develop a framework for assessing and comparing national, regional and local policies to attract immigrants with ancestral ties to left-behind areas; 2) to better understand the factors that contribute to migrants’ integration and desire to stay in such areas; 3) to thereby provide evidence-based policy enhancements that contribute to the resilience of these areas and to migrants' well-being.

Keywords: repopulation policies,left behind places,international roots migration