Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A new perspective on the metabolic pathway to neuronal dysfunction: Using organs on a chip to elucidate the role of the brain microvasculature (SweetBrain)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1487438.0
EU funding (EUR): 1487438.0
Participants: 1
Project status: SIGNED

Despite decades of research, the underpinnings of central nervous system (CNS) diseases and clear pathways to effective treatment remain elusive, mainly because of a scarcity of adequate models and methods with the capacity to elucidate human brain physiology. Recent studies suggest that high glucose levels are correlated with neuronal dysfunction and neurodegeneration, yet very little is known about the mechanisms of this relationship. Research in this vein has focused primarily on direct metabolic interactions between neurons and astrocytes, ignoring other cell populations in the neurovascular unit (NVU) that might have a meaningful role. My recent research revealed that the brain vasculature—the ‘gatekeeper’ through which all metabolites must pass to reach the neurons—has direct metabolic coupling with the neurons. Drawing from these observations, I adopt a previously unconsidered perspective and propose that the vasculature drives the neurodegenerative effects of hyperglycemia. Specifically, I hypothesize that high glucose levels change the metabolic function of the brain vasculature, thereby altering the direct endothelium-neuronal crosstalk and triggering neuronal dysfunction. To investigate this hypothesis, I will develop cutting-edge Organ-on-a-Chip (OoC) technology that overcomes the limitations of modeling NVU functionality and cell-cell interactions. Specifically, I will: (1) establish a human-relevant NVU-OoC model for metabolic and functional interactions, in which different cell types grow separately while remaining metabolically and functionally coupled; (2) identify the major metabolic and functional interactions in the human NVU at homeostasis and under diabetic conditions; and subsequently (3) target the vasculature communications to diminish neuronal dysfunction. This research has the potential to revolutionize the study of CNS disease, pointing to an unexplored pathway to a cure, and illuminating fundamental questions regarding brain metabolism.

Keywords: brain metabolism,organs on a chip
Deformable Surface Tracking and Alpha Matting for the Automation of Post-production Workflows (AutoPost)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Belgium
Call: Support the growth of ICT innovative Creative Industries SMEs (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 1092750.0
EU funding (EUR): 948150.0
Participants: 7
Project status: CLOSED

In today´s era of automation and intelligent systems, a huge amount of video and film post-production work can still only be completed manually by specialized artists. In the case of visual effects (VFX) and 2D/3D conversion, artists spend about 20%-40% of their time doing labour-intensive additive and subtracting retouching. To address this issue, AutoPost will develop productive end-user solutions for small and medium post-houses, by embedding scientific state-of-the-art solutions for tracking deformable surfaces and natural video matting into the established workflow of visual effects and 2D-to-3D conversion artists. The AutoPost solutions will considerably reduce the workload and will make post-production performance more efficient, both creatively and financially, while still allowing supervision and artistic control of the results by the user. To ensure a professional adoption, the developed tools will be accessible through a general plugin suite, The AutoPost Plugin Suite, for industry-standard post-production platforms as well as SDKs and functional plugin prototypes. The developments will be accomplished in accordance with the real-world working requirements defined by SME project partners from the creative industries, who will act as stakeholders for other post-houses, end-users and further external partners from their networks. AutoPost’s tools will allow companies to reduce the weight of the labour cost factor in their competitive profile, aiming to boost the competitiveness of the EU post-houses in every market, especially since infrastructure and labour costs can dictate where in the world films are finally produced. To fulfil AutoPost’s objectives, a complementary and compact group of engineers, VFX and 2D/3D conversion artists, compositing experts and business-related professionals will work together, specifying, developing and evaluating the tools.

Keywords: post production,plugin,film,video,visual effects,2d 3d conversion,tracking,deformable surface tracking,matting,natural video matting,creative,artist,workflow automation
Consistent representation of temporal variations of boundary forcings in reanalyses and seasonal forecasts (CONFESS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Spain,Italy,France,United Kingdom
Call: Copernicus evolution: Research activities in support of the evolution of the Copernicus services (H2020-SPACE-2020, 2020)
Start date: 2020-11-01
End date: 2024-03-31
Duration (months): 41.0
Total project cost (EUR): 1534200.0
EU funding (EUR): 1279987.5
Participants: 4
Project status: SIGNED

A climate resilient society requires reliable monitoring and forecasting information of the climate trends, patterns and disturbances, both at global and regional scales. Through CONsistent representation of temporal variations of boundary Forcings in reanalysES and Seasonal forecasts, CONFESS will contribute to the emerging societal need for an enhanced Copernicus Climate Change Service (C3S) that can support adaptation and mitigation strategies facing increased frequency and intensity of climate extremes. The aim of CONFESS is to improve the reliability and usability of C3S information in the land-atmosphere coupled system by exploiting new and improved Earth Observations data records of land-use, vegetation states and surface-emitted aerosols delivered across different Copernicus Services. CONFESS developments will be integrated consistently for use in future C3S systems, enhancing the service’s accuracy by representing annual changes of land use, adding satellite-derived and prognostic vegetation states along with aerosols emissions due to hazardous/extreme events such as volcanic eruptions and large-scale biomass burning (e.g. wildfires). The added capacity to represent temporal variations and trends of these variables and the occurrence of hazardous/extreme events will be supported by a rapid uptake of new Earth Observations. The impact on the Earth system will be evaluated on the quality of global reanalysis as well as seasonal forecasts using state-of-the-art modelling systems. The infrastructure and knowledge developed within CONFESS will contribute to improve the C3S capabilities for reliable monitoring and forecasting with particular focus on extremes.

Keywords: climate reanalysis,land biosphere variability,aerosols emissions from extreme,hazardous events,earth system modelling integration,enhanced seasonal forecasting
Improving the services of the NMP NCP Network through Transnational Activities (NMP TeAm 3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Coordination and support actions
Countries involved: Israel,Germany,Italy,Poland,Greece,France,Portugal,Portugal,United Kingdom
Call: Support for NCPs (H2020-NMP-CSA-2014, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 599135.12
EU funding (EUR): 599135.12
Participants: 10
Project status: CLOSED

NMP TeAm 3 is the continuation of the successful EU projects NMP TeAm 1&2. It aims to facilitate transnational cooperation between NCPs within the Industrial leadership Part with a view to identifying and sharing good practices and raising the general standard of support by the NMP NCPs to programme applicants as described in the work programme. NMP TeAm 3 will achieve a consistent, improved and professionalised NCP service across Europe, thereby helping simplify access to Horizon 2020 calls, lowering the entry barriers for newcomers, and raising the average quality of proposals submitted. NNP TeAm 3: - Will create the mechanisms and tools for capacity building of NCPs' skills that will ensure the NCP Network's high and consistent level of services to clients. These will include 10 training events, 10 staff exchanges and twinning schemes and self -assessment through benchmarking. - Will provide the necessary tools to all NMP NCPs so that they can assist their clients to increase their success rate in H2020 and lower the barriers for participation for new applicants. These will include the improvement of the Partner Search Facility of NMP TeAm 1&2, organisation of 4 brokerage events at large EU presidency conferences and 6 virtual information seminars for clients on H2020. - Will improve the outreach of the NMP NCP Network and maximise the impact of its activities, services and results to a wide audience of clients and stakeholders. This will be achieved through the continuation of the NMP TeAm website, which is already a focal point of the community of NCPs and programme applicants, continuous dissemination of information through social media and participation of NCPs at large NMP related events to provides assistance and services. NMP TeAm 3 will also maintain and create new links with stakeholders like the Enterprise Europe Network, European Technology Platforms and other NCP Networks to reach as many as possible H2020 applicants.

Keywords: national contact points,support to horizon 2020,benchmarking for ncps,capacity building for ncps and h2020 applicants,brokerage events,partner search for h2020 applicants
Strategies towards Excellence in Immuno-Oncology (STREAM)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Norway,Poland,United Kingdom,United Kingdom
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1190261.25
EU funding (EUR): 1190261.25
Participants: 5
Project status: CLOSED

In 2013, the Science magazine announced Immunotherapy of cancer as the ‘Breakthrough of the Year’. The results of ongoing clinical studies with new cancer immunotherapeutics strongly support this enthusiasm. Following the lead of the top research groups, the Coordinator of the present proposal, Medical University of Warsaw (MUW) displays a predominant ambition of becoming a major player in the thriving area of Immuno-Oncology. MUW is one of the leading centres of competence in the Oncology field in Poland and presents a robust desire for further improvement of its excellence merits. Therefore, the main concept of the STREAM proposal is to bring together the high-level European research organizations with synergistic scientific and innovative expertise in the field of Immuno-Oncology, in order to establish an international, long-term, strategic partnership with MUW. The main model of the STREAM proposal is to foster enhanced scientific dialogue and twinning between MUW and four outstanding research centres via trans-national visits of scientific personnel, joint organization of a summer school and workshops, as well as promoting the active participation of STREAM researchers in the prestigious scientific conferences. Within the duration of the current project we intend to significantly enrich MUW’s, regional and national quality profile regarding all of the variables of Composite indicator of Research Excellence in the Immuno-Oncology area. We will also set a new standard for conducting bioresearch and innovative thinking in Poland. We expect that the scale, ambition, and innovative character of the proposed project will bring the MUW’s excellence to a new level - internationally recognized and competitive, in order to contribute to the well-being of the society and knowledge-based economy of Poland and EU. Our proposal provides an exceptional occasion to achieve real impact on human health, quality of life and economic status in the new area of enlarged Europe.

Keywords: immuno oncology,cancer research,translational studies,public health,international cooperation,partnership,excellence,innovation,new standard
Capacitive Identification Tokens (CAPID)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Belgium,Poland,Belgium,Belgium,Netherlands
Call: Thin, Organic and Large Area Electronics (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 3474318.75
EU funding (EUR): 3474318.7
Participants: 7
Project status: CLOSED

Almost every person in Europe now has access to a connected touch device and the creation of new capacitive sensing devices has become easy and cost effective. Building on this, the CAPID project wants to develop ‘c-tokens’, that interact with these touchscreen and capacitive readers. C-tokens are thin and flexible, metal-oxide tags, integrated in paper and plastic products. The tags will send a dynamic capacitive signal into the reading devices. C-tokens make it possible to identify and locate low cost and high volume products, like cards or labels, to the internet, just by putting them on a touchscreen. The number of different ID’s is very high and make it possible to create unique codes per product. The very small footprint (much smaller than NFC or QR) and low thickness make it possible to integrate them in a product as thin and flexible as a playing card. They are more secure than QR (can be copied) or NFC (can be read from distance) and they can detect the exact position of an object (important for board game applications). The tags will harvest the necessary energy from the capacitive screen, trough capacitive coupling or photovoltaic technology. The high end c-token can communicate with the touchscreens bi-directionally, making use of photo sensors inside the cards. Objective 1 is the development of the different components, like the flexible thin-film IC’s in metal oxide technology and printed electrode arrays as well as the integration of photovoltaic and photosensors. Objective 2 is the implementation of scalable manufacturing processes for assembly and integration of all the components into finished products. Objective 3 is the realization of application demonstrators, one for each of the 3 end-users in the consortium. A first application is an interactive board game (Cartamundi Digital), a second application focuses on a more secure ticket system for events (ICS Festival Services) and the third one is providing a new way of mobile payments through touc

Keywords: capacitive identification tokens
Fast IoT market take-up through The Things Networks (FITT-iN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Netherlands
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Things Industries (TTI) is a Dutch SME that focuses on the rise of the Internet of Things (IoT). The company expects that, upon the further expansion of the digital economy, a number of societal developments will greatly affect our daily life. Leading in all these developments will be in the domain of the IoT, which will gain a crucial place in the digital economy, based on the following fundamental ideas: - The digital transformation of products: all products and services that can be made digital, smart or automated, will be. - The revolution of demand and offer: all traditional business models will be replaced by disruptive models. - The inexhaustible need for data: the digital economy will have a continuously growing need for the collection, exchange and analysis of data. TTI recently launched TTN, the first open, free-to-use IoT data network solution in the world, providing full coverage for the Amsterdam metropolitan region. Ever since, the network is being used successfully by companies and citizens of Amsterdam, and the first applications on this network have been developed and demonstrated. Currently, over 250 strong and active communities (60 within the EU) have set up local TTN-networks all over the world. TTI has established its current status with own funding, awards/prizes, subsidies, and profits from IoT/LoRaWAN gateway hardware sales and related consultancy. In order to expand exponentially, TTI will have to assess how to monetize its network and technology position optimally. The goal of this SMEInst proposal is to assess three different business models how to monetize its technology position through to scale up and growth. Specific objectives in this H2020-SMEINT Phase 1 feasibility study are: - Explore promising business cases for TTI networks. - Evaluate the required specifications and characteristics of these applications with potential partners, citizens, consumers and/or clients. - Elaborate on a detailed business plan (D1).

Keywords: internet of things
Anharmonic Semiconductors (ANHARMONIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1700000.0
EU funding (EUR): 1700000.0
Participants: 1
Project status: SIGNED

Recent studies of halide perovskite semiconductors (SCs) showed that they exhibit a unique combination of very-low defect density, self-healing properties and low exciton binding energies that result in excellent photovoltaic activity. I hypothezise that the fundamental property that sets the halide perovskites apart from conventional SCs and gives rise to their beneficial properties is strongly anharmonic lattice dynamics. Large amplitude, local polar fluctuations that result from lattice anharmonicity localize the electronic states and enhance the screening of electric charges within the material. In other words, in some aspects, halide perovskites behave more like a liquid than a crystalline solid. Stimulated by the recent discoveries on halide perovskites, I aim to generalize our understanding of the relationship between lattice anharmonicity and the electronic properties of SCs. The potential outcome of this investigation will be a novel scheme to design SCs with desirable properties where lattice anharmonicity is used as a new material-engineering tool. My strategy is to perform comparative studies in both inorganic ionic crystals and small-molecule organic crystals. We will use low-frequency Raman spectroscopy to quantify anharmonic lattice dynamics and compare between different crystals to identify the factors that induce anharmonicity in solids. Photoluminescence, reflectance, time-resolved terahertz and impedance spectroscopies will be used to probe the SCs optical properties, carrier mobilities and lifetimes, and their dielectric response. I expect to find that as anharmonicity increases, the dielectric response and carrier lifetimes increase while carrier mobility decreases. Finally, we will develop a modulated Raman spectroscopic methodology that will identify specific lattice motions that are coupled to band-edge carriers, thus elucidating the microscopic mechanism of carrier-lattice interactions.

Keywords: raman spectroscopy,halide perovskites,organic semiconductors,structural dynamics,electron phonon interaction
Multi-dimensional Intervention Support Architecture for Gamified eHealth and mHealth Products (iGame)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Spain,Germany,Italy,North Macedonia,Hungary,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 837200.0
EU funding (EUR): 837200.0
Participants: 7
Project status: SIGNED

This project investigates evidence based gamification techniques for eHealth and mHealth and develops a multi-dimensional intervention support architecture/platform in order to improve the efficacy of gamified eHealth products (web-based health tools and health apps). The project will develop advanced game production techniques with ready-to-use toolkits to accelerate the innovation process for eHealth and mHealth products. This will help digital industry (games, IoT and ICT) to innovate new products and services with science and technology underpinnings. It addresses fundamental issues of gamification for eHealth interventions including its development process and evaluation methods for measuring its efficacy. The outcomes of the project, manifested as gamification Toolkits, an integrated ICT Platform, and clinical assessment Methodologies as whole as a framework, will greatly accelerate the pace and scale of eHealth innovation by transforming and increasing its quality and efficiency through advanced technology tools, frameworks and methodologies. By using gamified physical activity engagement as a clinical intervention case study, the proposed framework will be evaluated and tested within patients in primary care settings, who are identified as physical inactive and at risk for their conditions due to sedentary behaviours. However, the gamification framework remains flexible and portable to other contexts of digital health interventions. The project presents two key innovation components: • An innovative collaborative R&D programme in collaboration with industry, focus on delivering solutions to address challenges in the development process of gamified eHealth products i.e. productivity and efficacy. • A strong and sustainable model of collaboration with digital industry and other relevant stakeholders fully integrated to develop the innovation capacity in SMEs in eHealth products, specifically gamified eHealth products and services.

Keywords: gamification for health interventions,ehealth and mhealth products,digital economy