Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
optimization of Particle Accelerators: A Marie Curie Initial Training Network (OPAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Spain,Switzerland,Austria,Slovenia,Germany,France,Spain,Sweden
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 5939699.0
EU funding (EUR): 5939699.0
Participants: 12
Project status: CLOSED

There are more than fifteen thousand particle accelerators in the world, ranging from the linear accelerators used for cancer therapy in modern hospitals to the giant 'atom-smashers' at international particle physics laboratories used to unlock the secrets of creation. For many decades these scientific instruments have formed one of the main pillars of modern research across scientific disciplines and countries. The optimization of the performance of any particle accelerator critically depends on an in-depth understanding of the beam dynamics in the machine, the availability of simulation tools to study and continuously improve all accelerator components from beam handling elements to rf cavities, a complete set of beam diagnostics methods to monitor all important machine and beam parameters with high precision, and a control and data acquisition system that links all the above. The oPAC consortium proposes to carry out collaborative research into all the above aspects, with the aim to optimize the performance of present and future accelerators that lie at the heart of many research infrastructures. The network brings together leading research centers, universities, and industry partners to jointly train the next generation of researchers in this interdisciplinary field. oPAC aims at developing long term collaboration and links between the involved teams across sectors and disciplinary boundaries and to thus help defining improved research and training standards in this important field.

Keywords: accelerator physics,beam physics,control systems,instrumentation,light sources,particle colliders,fundamental research
Novel Processing approaches for the development of food products Low in fAt, Salt and sUgar (PLEASURE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Fork to farm: Food (including seafood), health and well being
Action type: Collaborative project
Countries involved: Germany,Romania,Belgium,France,Ireland,France,Germany,Germany,France,Spain,Ireland,Greece,Netherlands,Ireland,Spain
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 3956858.4
EU funding (EUR): 2983864.0
Participants: 17
Project status: CLOSED

More than 60% of all reported diseases in modern industrial countries are said to have their origin from malnutrition (low vitamin intake, high caloric food (fat and sugar)). As an important cause of this the high consumption of fat (saturated and trans-fatty acids, salt (sodium) and sugar (mono- and disaccharides) has been identified. With the change of society, the consumer’s pattern towards food consumption has and is changing dramatically. While less and less people prepare their meal at home, the increase of TV cooking shows demonstrates the opposite (European paradox). The trend towards processed and convenience food is a challenge for the food industry and those products have to be of high quality and safety at low price. Fat (saturated and trans-fatty acids), salt and sugar fulfil important functions in food manufacturing as well as in the human metabolism. But meanwhile in the industrial countries their excessive consumption can lead to health problems as stated earlier. Saltiness and sweetness perception are strong markers of the sensorial attributes of food. In the past years there have been many attempts made – both by industry and by science to overcome the problem with only limited or no success. All approaches known where either based on nutritional recommendations (like e.g. “low carb”) or based on substitutes like e.g. sweeteners. The use of replacers to reduce the salt (NaCl), sugar (sucrose, glucose, and fructose) and fat (saturated and trans-fatty acids) content has been very attractive for the food industry as it is an approach which requires only low cost in terms investments (no equipment needed) and ingredients. However, most of the approaches felt due to lack of consumer acceptance due to a different taste perception of the products. The PLEASURE project will be the first project addressing this challenge from the processing side.

Keywords: salt,fat,sugar,sensorial perception,spatial distribution of tastant,high pressure,high pressure homogenization,emulsion technology,biotechnology,enzymatic sugar reduction
Improving the resistance of legume crops to combined abiotic and biotic stress (ABSTRESS)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,France,Hungary,Spain,Germany,United Kingdom,Spain,Italy,Czechia,Italy
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 3997061.7
EU funding (EUR): 2999074.0
Participants: 15
Project status: CLOSED

ABSTRESS applies combined, integrated systems biology and comparative genomics approaches to conduct a comprehensive study of the gene networks implicated in the interaction of drought stress and Fusarium infection in legumes. It uses Medicago truncatula as a model to rapidly identify characteristics for introgression into elite pea varieties and a field test of their performance against existing commercial varieties. The project will demonstrate the advantages of applying advanced phenotyping methods for the generation of improved varieties of a commercial crop. Legumes have been chosen as the preferred study crop because they are susceptible to a combination of abiotic and biotic stresses. By increasing their cultivation, they offer the greatest opportunity to reduce the generation of greenhouse gases from agriculture and hence contribute to the efforts to control climate change. Therefore ABSTRESS aligns with the European Strategic Research Agenda 2025. ABSTRESS will achieve a step change in “sustainability in agriculture” by undertaking breeding research that seeks to develop varieties having improved resistance to a combination of biotic and abiotic stresses. The novelty of the project is demonstrated by the generation, identification and understanding new genetic materials; addressing commercial requirements for the development of a successful new crop variety by using SME expertise; testing new in a range of growing conditions; addressing impact on Fusarium in other crops; have application to crop breeding generally; incorporating drought stress which is likely to be a major factor for climate change; developing high throughput molecular phenotyping, to gain a step change in the speed of the breeding cycle. Thus, this well structured, innovative research can lead to ground breaking achievements in plant breeding. These will help to ameliorate climate change and develop the tools to mitigate their effects on a sustainable food /feed supply chain.

Keywords: legumes,pea,medicago,fusarium,drought,plant stress,metabolomic profiling,phenotypes
Supporting the role of the Common agricultural policy in LAndscape valorisation: Improving the knowledge base of the contribution of landscape Management to the rural economy (CLAIM)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Italy,Germany,European organisations area,Austria,Netherlands,Poland,Türkiye,Bulgaria,France,Spain
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 1874220.0
EU funding (EUR): 1499400.0
Participants: 11
Project status: CLOSED

The provision of public goods (including landscape services) in rural areas is recognized as one of the key topics for the future of agriculture and rural policy. Agriculture plays a major role in landscape management through its complex interlinkages with landscape features. In turn, the Common Agricultural Policy (CAP) remains an important driver of landscape management due to its importance as a determinant of farming activities in the EU. The main objective of the CLAIM project is to provide the knowledge base to support an effective CAP policy design in the direction of improved landscape management, particularly providing insights into the ability of landscape to contribute to the production of added value for society in rural areas. CLAIM is focused in particular on understanding and enhancing the contribution of landscapes management to socio-economic development and agricultural competitiveness in rural areas. This will be based on a pragmatic consideration of landscape services and their analysis through a mixed-method approach, taking into account the wider EU policy strategies (in particular related to innovation and the bioeconomy). The main expected result of the CLAIM project is an evidence-based policy support framework on the different and possible contributions of agriculture and the CAP to landscape management. The framework will be mainly developed and validated through a set of 9 case studies, a strong involvement of stakeholders at different territorial levels and a wide coverage of the perspectives of EU and candidate countries. The framework will finally take the practical form of a web-based manual to be implemented in accordance to stakeholders needs and indications.

Keywords: landscape,common agricultural policy,rural development
3to4: Converting C3 to C4 photosynthesis for sustainable agriculture (3TO4)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: United Kingdom,Germany,United Kingdom,Germany,China,Estonia,France,Germany,Italy,Philippines,United Kingdom,Portugal,Türkiye,Italy,Belgium,Switzerland,United Kingdom,United Kingdom
Call:  (FP7-KBBE-2011-5, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 8940658.32
EU funding (EUR): 6806560.0
Participants: 20
Project status: CLOSED

Most plants use the C3 pathway of photosynthesis that is compromised by gross inefficiencies in CO2 fixation. However, some plants use a super-charged photosynthetic mechanism called C4 photosynthesis. The C4 pathway is used by the most productive vegetation and crops on Earth. In addition to faster photosynthesis, C4 plants demand less water and less nitrogen. Overall, our aim is to introduce the characteristics of C4 into C3 crops. This would increase yield, reduce land area needed for cultivation, decrease irrigation, and limit fertiliser applications. If current C3 crops could be converted to use C4 photosynthesis, large economic and environmental benefits would ensue from both their increased productivity and the reduced inputs associated with the C4 pathway. It is important to note that the huge advances in agricultural production associated with the Green Revolution were not associated with increases in photosynthesis, and so its manipulation remains an unexplored target for crop improvement both for food and biomass. Even partial long-term success would have significant economic and environmental benefits. Efficient C4 photosynthesis would be achieved by alterations to leaf development, cell biology and biochemistry. Although initially we will be using model species such as rice and Arabidopsis we envisage rapid transfer of technological advances into mainstream EU crops, such as wheat and rape, that are used both for food and fuel. We will build capacity for C4 research in Europe in this area by the training of future generations of researchers. To achieve this aim we need to increase our understanding of the basic biology underlying the C4 pathway. Our specific objectives will therefore address fundamental aspects of C4 biology that are needed for a full understanding the pathway. Specifically we aim: 1. To understand the roles and development of the two cell types (mesophyll and bundle sheath) in C4 plants. 2. To identify mechanisms controlling the ex

Keywords: carbon fixation,biomass,increased crop yield,c4 photosynthesis,water use efficiency,nitrogen use efficiency,rice,wheat,oilseed rape,transcriptomics,green revolution
HEMatopoietic cell IDentity : genetic and epigenetic regulation in normal and malignant hematopoiesis (HEM_ID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy,Austria,France,France,Greece,Spain,Netherlands,France,United Kingdom
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2011-11-01
End date: 2015-10-31
Duration (months): 48.0
Total project cost (EUR): 3269702.05
EU funding (EUR): 3269702.05
Participants: 12
Project status: CLOSED

In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been well defined in the last years, the precise molecular circuits governing the balance between proliferation/commitment/specification and how these are corrupted in disease are largely unknown. The focus of Hem-ID is a highly integrated approach to study the functional interactions between the genetic regulatory circuits orchestrated by transcription factors –TFs-, (that direct the progressive cell type specification) and epigenetic mechanisms (that establish the “cellular memory” that fixes cell fate decisions during differentiation) in physiological hematopoiesis and in leukemia with the final goal of formulating novel diagnostic/prognostic markers and therapeutic approaches in treating leukemias. HEM_ID will: -Decipher Modular Networks assembled by master TFs controlling hematopoietic self renewal and differentiation and the molecular dynamics of TFs/DNA interactions by unique biophysical approache -Identify epigenetic modifiers (new relevant loci, -epiQTLs, DNAmethylation, Polycomb dependent-gene silencing, miRNA and long non coding RNAs) involved in the pathogenesis of leukemias. The strength of Hem-ID ITN lies in the high quality multidisciplinary -but strictly integrated- expertise and technological platforms covering the complete pathway from basic research to its clinical exploitation- contributed from both public Institutions and Private sector and made available to Hem-ID Fellows. Besides research, an integrated training program of scientific and complementary activities will be offered to HEM-ID Fellows that will complement and strengthen their career development.

Keywords: hematopoiesis,genetic regulation,epigenetic regulation,transcription factors,chromatin,stem cells,leukemia
Few Spin Solid-State Nano-systems (S^3NANO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,United Kingdom,Germany,Germany,Switzerland,Netherlands,Netherlands
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 4000024.0
EU funding (EUR): 4000024.0
Participants: 9
Project status: CLOSED

This network brings together an exceptionally strong group of world leading experts in nano-science and technology in order to achieve breakthroughs in understanding and successful utilisation of nanoscale systems in future devices. The focus of the consortium is on few spin nano-systems in solid-state materials including III-V semiconductors and Carbon-based structures: carbon nano-tubes, graphene and diamonds. Such wide material base emphasizes the truly intersectoral character of this collaboration opening opportunities for crossing the boundaries between several areas of solid-state physics and technology. In order to ensure the highest impact of this collaboration in the emerging supra-disciplinary field of physics and applications of spin nano-systems, we bring together the expertise of the world top class research institutions and industry from 4 European countries. The network will deliver top international level multidisciplinary training to 11 early stage researchers and 5 experienced researchers, offering them, in particular, an extended program of multinational exchanges and secondments. The research and development under this network will undertake a broad scope of tasks important for implementation of spin nano-systems in future devices, such as non-volatile ultra-compact memories, nano-magnetometers, spin qubits for quantum information, and high-efficiency single photon sources. The objectives of the network include: (1) Realization and optical control of coherent single spins in nanostructures; (2) Spin-orbit interaction and spin-orbit qubits in nanostructures; (3) Advanced techniques for manipulation of nuclear spins on the nanoscale; (4) Generation of long-distance entanglement between single spins.

Keywords: physics of semiconductors,solid state physics,spectroscopy,optical and dielectric properties,electron-based nano-devices,magnetic resonance
Initial Training for Atmospheric Remote Sensing (ITARS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany,Romania,Greece,Spain,Italy,United Kingdom,Netherlands,Germany
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 3693644.0
EU funding (EUR): 3693644.0
Participants: 9
Project status: CLOSED

This proposal brings together a group of universities, research organisations and high-tech companies from different disciplines (meteorology, geosciences, physics, electrical engineering, mathematics) with the aim to foster training and further development in the area of remote sensing of the atmosphere. The last years have brought a rapid development in instrumental techniques, i.e. lidar, radar, radiometry, that have great potential to monitor atmospheric composition and dynamics in unprecedented detail. Such instrumentation is urgently needed to address important topics related to climate change, numerical weather forecasting, and atmospheric pollution. Most prominently aerosol-cloud interaction as the single largest uncertainty in current climate projections requires the exploitation of emerging observational techniques to improve the parameterisation of aerosol and cloud processes in atmospheric models. Because today’s curricula do not reflect these issues, ITARS (Initial Training for Atmospheric Remote Sensing) aims • to impart an in-depth understanding of instrumentation and algorithms needed to retrieve geophysical quantities and atmospheric applications, • to foster the synergy of different sensors by bringing together experts from the individual techniques, • to develop and implement pan-European courses on atmospheric remote sensing by exploiting new web-based techniques, and • to close the gap between the specialized development of single instruments and atmospheric applications by training a new generation of scientists in academia and the private sector.

Keywords: atmospheric physics (climate change),aerosols (climate change),observation systems (climate change),remote sensing (climate change),meteorology
Transglutaminase in disease: a novel therapeutic target? (TRANSPATH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Netherlands,Hungary,Italy,Norway,Italy,Türkiye,France,United Kingdom
Call:  (FP7-PEOPLE-2011-ITN, 2011)
Start date: 2011-11-01
End date: 2015-10-31
Duration (months): 48.0
Total project cost (EUR): 3740034.01
EU funding (EUR): 3740034.01
Participants: 11
Project status: CLOSED

TRANSPATH is a multisectorial Network designed to facilitate the exchange of knowledge and technology between 7 leading European research teams and 3 SME partners and 2 associate SME Partners involved in basic and applied research into transglutaminase (TG) related human diseases. Its ambitions are to accelerate the development of new strategies for the treatment and diagnosis of human diseases related to transglutaminases, including metastatic cancer, neurodegeneration and celiac disease. The subject is highly relevant as deregulation of tissue transglutaminase activity is observed in a number of human diseases while the exact mechanisms are still largely unknown. The project targets this unmet clinical need. The main objectives are :1) to establish the molecular nature of the role of transglutaminases in the pathogenesis of diseases which are known to involve these multifunctional enzymes with a view to developing novel specific inhibitors and new therapeutic approaches which will have a major impact on their treatment ;2) provide an extensive cross sectorial scientific and supporting training network that will increase the capabilities of highly skilled researchers for the European biotechnology industry and academia.

Keywords: natural sciences,cell biology,molecular biology