Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Inclusive Identities in the Context of Increasing Culturally Diverse Workplaces (WORKPLACE DIVERSITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-11-01
End date: 2011-10-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

With increasing globalization and migration the workplace is becoming more and more culturally diverse worldwide. As finding meaningful employment is an important factor for successful integration into the new country of settlement, interactions between different ethnic groups at the workplace need to be specifically looked at. The overall focus of this research proposal is on influences of national and organizational factors on successful management of cultural diversity at the work floor. The goal is to understand the formation and role of inclusive identities in a work context that ensure a sense of sharedness while being grounded in awareness and appreciation of mutual differences. This will not only reduce social tensions but also produce positive outcomes in our society. The theoretical rationale behind is grounded in theories on social identity, self-categorization and acculturation including multidisciplinary perspectives. It is assumed that different policies and histories of migration, country-specific demographics and economics and unique cultural belief and value systems influence the direction and strengths of the diversity effects within a society. With co-operation partners in Austria, the Netherlands and New Zealand the opportunity for cross-national comparative studies is given to get a more holistic picture of general and specific preconditions, processes and effects of inclusive identities in the context of increasing culturally diverse workforces and multiculturalism in Europe. The scientific knowledge gained shall lead to recommendations for successful diversity management and the development of diagnostic instruments that consider the cultural and organizational context and the specific ethnic groups involved in the interactions. Presentations and publications within and outside the academic community shall secure the knowledge transfer to potential end-users and relevant decision makers and thus contribute to European competitiveness.

Keywords: social sciences,multiculturalism,cultural diversity,workplace,inclusive identities,diversity management,acculturation,cross-national comparisons,national and organizational context factors
Molecular Mechanism of Synovial Joint Lubrication (LUBRIJOINT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2009-06-01
End date: 2014-01-14
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

This application is concerned with the study of the molecular basis of skeletal joint lubrication in order to improve the design of artificial joint prostheses. These joints eventually fail mainly because of problems associated with inadequate lubrication and revision surgery is an increasingly expensive burden as the population ages. A better understating of such processes should lead to better strategies for minimizing lubrication breakdown in natural joints, as well as to strategies for improving lubrication and wear of prosthetic joint implants and other biological surfaces where prevention of adhesion is required. This proposal seeks to investigate the molecular basis of the remarkably efficient lubrication in mammalian synovial joints, by constructing surfaces partly analogous in structure to that of articular cartilage and measuring forces between them under strictly controlled conditions. Using a surface force balance apparatus, we intend to measure the normal and friction forces between layers of (i) negatively charged hyaluronic acid (HA)-aggrecan (ii) lubricin and HA-aggrecan and (iii) HA-aggrecan and phosphatidylcholine-based phospholipids (PL). Firstly, a pre-biotynilated HA will be attached to mica surface via streptavidin. Aggrecan, extracted from mammalian cartilage, will be added to the HA-coated mica to form supramolecular aggregates similar to those at the cartilage/synovium interface. Secondly, a well-characterized lubricin layers and in a later stage fluorescent or radio-labeled PL will be adsorbed onto the HA-aggrecan mica surface and the interactions studied. Our ultimate goal is to address the interactions between lubricin, PL and HA – the main players in synovial lubrication. At each stage of the project, mica-attached layers will be characterized using AFM, X-ray photoelectron spectroscopy and SFB, and their tribological properties will be examined, on a nanometer scale, in a wide range relevant to physiological conditions.

Keywords: osteoarthritis,articular cartilage,boundary lubrication,aggrecan,lubricin,phospholipids,synovial fluid,surface force balance,nano-tribology
Study and Identification of ADAM10 as Neuronal α-secretase in relation to Alzheimer’s disease (ADAMNEURON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-04-01
End date: 2012-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

With life expectancy increasing rapidly in our Western world, Alzheimer’s disease (AD), a progressive neurodegenerative disorder resulting in dementia, is becoming more common, however no cures or effective treatments are currently available. The neurotoxic amyloid-β (Aβ) peptide appears central to AD pathogenesis, and is generated by β- and γ-cleavage of the larger amyloid precursor protein (APP). APP can also be cleaved by α-secretase, which cleaves within the Aβ peptide region and hence precludes the generation of Aβ. To date, the exact nature of α-secretase in the brain remains unknown, although ADAM10 (A Disintegrin And Metalloproteinase) seems to be the most likely candidate. This proposal is designed to determine definitively whether ADAM10 comprises indeed neuronal α-secretase activity in vivo, and to determine which factors regulate its activity. Using human APP (hAPP) transgenic mice deficient in neuronal ADAM10 expression we will determine whether levels of α-cleaved APP are down- and Aβ upregulated, whether this results in increased Aβ deposition and neurodegeneration, and whether ADAM10 is involved in learning and memory. Using neuronal cell culture we will determine whether growth and neuroprotective factors induce ADAM10 expression. In addition we will set up a screening system that will be used to identify molecules that regulate ADAM10 expression. These experiments will further our understanding of α-secretase in the brain and will aid in the development of novel therapies for AD.

Keywords: health sciences,alzheimer's disease,alpha-secretase,adam10,app,amyloid,transgenic animals,therapy
Contribution of the WW domain-containing oxidoreductase, WWOX, gene toward mammary tumorigenesis (WOX IN BREAST CANCER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-03-01
End date: 2012-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Chromosomal and genomic abnormalities affecting chromosome 16q have frequently been reported in cytogenetic and allelotypic studies of various epithelial tumors, including breast cancer. The WWOX gene has been recently cloned and described. WWOX spans a genomic region of more than 1 MB located in ch. 16q23.1. This specific region is the most frequent target for LOH affecting 16q in breast cancer. The critical role of WWOX in breast cancer was recently highlighted by the suppression of tumor growth in mice and formation of spontaneous tumors in targeted Wwox heterozygous mice. Biochemical studies demonstrated that Wwox suppresses the transactivation ability of interacting oncoproteins that are well implicated in breast cancer. While our data and others show that Wwox is critical for breast cancer onset, it is not clear the role of Wwox in normal development of mammary gland and its contribution toward breast tumorigenesis. Obviously, understanding how Wwox functions to suppress tumorigenesis will be essential for the future development of effective breast cancer therapies. Our hypothesis is that WWOX is an important breast cancer gene that suppresses tumor growth and that abnormalities affecting this gene at the genomic, transcriptional and protein levels are relevant in carcinogenesis. Thus, we propose to engineer a mouse model that lack the expression of Wwox in mammary gland epithelium and to investigate the mechanism underlying Wwox function contributing to breast cancer. In Aim1, we will generate a mouse model that lacks expression of Wwox in mammary cells. In Aim2, we will utilize the mouse model from Aim1 to study the contribution of Wwox toward mammary tumorigenesis. In Aim3, we will study Wwox candidate interacting proteins to better understand how Wwox functions to suppress mammary tumor growth. The proposed study will elucidate the mechanism of Wwox action in breast cancer and will identify Wwox as important novel therapeutic target for cancer intervention

Keywords: health sciences,cancer,tumor suppressor,knockout mice,mammary tumors,protein-protein interaction
Study and modification of T-cell receptor structure to enhance anti-tumor activity (ROLE OF TCR AFFINITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-10-01
End date: 2012-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Adoptive cell transfer of tumor-reactive lymphocytes has been shown to mediate the regression of large solid tumors in cancer patients. To overcome the need to isolate and expand tumor-reactive lymphocytes that pre-exist in the patient, it is possible to engineer cells to express a tumor-specific T-cell receptor - TCR, thus reprogramming their specificity. This pioneering therapeutic approach has been demonstrated to cause cancer regression in terminal melanoma patients that were refractory to previous treatments. However, little is known about TCR affinity requirements for mounting an optimal immune response in this context. While high affinity TCR may confer to the host lymphocyte excellent cytotoxic ability, several studies have shown that a too-high affinity may actually be detrimental to T-cell function. We therefore hypothesize that T-cell receptor affinity can influence the cytotoxic activity of lymphocytes in TCR-transfer treatment and that it is possible to define an optimal range or threshold of TCR affinity for mounting an efficient anti-tumor response. To test this, we propose to use the ovalbumine specific OT1 TCR model and to construct a CDR3-modified TCR library that will be retrovirally transduced into a reporter cell line. By combining the efficacy of a high-throughput screening method and the direct selection of mutant TCR ex-vivo, we are planning to isolate several TCRs with different affinities. These molecules will be transduced and expressed in primary lymphocytes to assess their biological function in-vitro. Using the B16-OVA melanoma model, we will adoptively transfer lymphocyte populations expressing mutant TCRs with different affinities and compare their activity in order to study the influence of TCR affinity on anti-tumor cytotoxic response. Thus, we expect to answer both fundamental and translational questions related to the ability of the immune system to recognize and eliminate tumor cells in the context of TCR-transfer treatment.

Keywords: immunology,t-lymphocytes,t-cell receptor,cancer immunotherapy,dna therapy
Predictive Techniques for System Level Analysis of Multi-Processors (PREDICTMP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2009-02-02
End date: 2013-02-01
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Emerging multi-processor products, such as Multi-Processor System on Chips (MPSoC), exploit concurrency to spread work around a system improving performance. European competitiveness in microelectronics such as wireless, networking, telecommunications, automobile, and consumer products relies heavily on improving reliability of such multi-processor systems. Electronic System Level (ESL) design methods and tools are important abstraction techniques to reduce complexity introduced due to concurrency; however, system level tools are still at their infancy. At the same time, traditional simulation based verification approaches fail to preserve concurrency that is inherent in such systems and suffer from the pitfalls of ad hoc specification. Similarly, formal verification is limited in its capacity and application domain. In this project, we will develop system level analysis techniques to increase reliability of concurrent multi-processor systems. In particular, we propose to develop novel system level predictive runtime verification techniques that preserve concurrency information and exploit it to find both actual and potential errors from executions of system level models. At the same time, we will develop system level error diagnosis techniques and coverage metrics to ultimately reduce verification and debugging time. New research and tools will be developed with a focus on automation and scalability and experiments will be performed on industrial applications.

Keywords: information technology,embedded systems,concurrent systems,microelectronics,electronic design automation,electronic system level,systemc,formal methods,runtime verification,assertions,testing
CENTRE FOR GLOBAL AND REGIONAL ETHNOGRAPHIES AT AARHUS UNIVERSITY (GLOREA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France,Denmark
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-07-01
End date: 2012-10-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Proposal to create a research centre for PhD and Postdoc researchers, focusing on ethnographic studies of migration and mobility in Europe, North America and the Asia Pacific. The Centre will be the core component of a specially created five year, then permanent, Research Professorship at Aarhus University. Projects at the Centre will be generated with external funding for two areas, crucial for exploring the human dimensions of globalisation and regionalisation, and which grow out of the recent research of the coordinating DIrector (Adrian Favell): on migration and mobility at the East-West, Balkan and Mediterranean borders of Europe, in comparative regional perspective with Latin American-US migration and the Asia Pacific; and on flows and mobility of highly skilled, creative professionals between hub cities in Europe and East Asia. PhD and Postdoc researchers, who will be recruited internationally, will receive comprehensive methods training in quantitative and qualitative techniques, as well as specialist training as ethnographers. The IRG will enable the return of an established European researcher who has spent 7 years as an Associate Professor of Sociology at UCLA.

Keywords: borders,cities,creative industries,east asia,europe,globalisation,interdisciplinary,migration,mobility,north america,research centre,trade,trafficking,transnationalism
"PRO –SENESCENCE” THERAPY IN PEDIATRIC BRAIN TUMORS (SENESCENCE THERAPY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland,Italy
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2009-02-23
End date: 2013-02-22
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

The irreversible cell growth arrest, termed cellular senescence, is emerging as an intrinsic tumour suppressive mechanism, which restricts progression of early cancerous lesions in humans. We have recently reported, a new type of cellular senescence, which occurs after the acute inactivation of the tumour suppressor Pten and significantly opposes tumorigenesis in vivo. Pten induced cellular senescence (PICS) occurs at early time points after Pten inactivation even in absence of cellular proliferation and DNA Damage. I will discuss the mechanism that trigger PICS in cancer, hailing the potential therapeutic implication of p53 stabilizing drugs and Pten inhibitors. Importantly, I will discuss how the oncogenic stress induced by complete loss of Pten can still triggers senescence in cells with low proliferative potential, such as cancer stem cells. I propose to apply this model to the treatment of pediatric brain tumors.

Keywords: anticancer therapy,pediatrics
Algorithms for Analysis of Genes and Genomes (ALGGENOMES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Slovakia
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2009-01-15
End date: 2013-01-14
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In this project, we propose to develop new algorithms and probabilistic models for analysis of biological sequences (genomes and proteins encoded by them). We concentrate mainly on computer science aspects, striving to design efficient algorithms capable of processing large biological data sets currently available. In collaboration with molecular biologists, we will apply our techniques to several bioinformatics problems, such as finding location of genes in genomic sequences, evolution of duplicated regions of the genome, and study of mitochondrial genomes of yeast. Finding better solutions for these problems will lead to better genome annotations available as a basic resource for biological and medical researchers. In addition to the research objectives, we plan to establish lasting collaboration between the computer science researchers at the Faculty of Mathematics, Physics and Informatics and the life science researchers from the Faculty of Natural Science at Comenius University, Bratislava. We will involve faculty members and students from both faculties in common research projects, seminars and other activities. Dr. Tomas Vinar has experience with interdisciplinary bioinformatics research at leading universities in Canada and U.S.A. which makes him an ideal candidate for this effort.

Keywords: algorithms,bioinformatics,probabilistic modeling
Implementing DNA barcoding into aquatic biodiversity research in Portugal and priming new macrobenthos monitoring tools (LUSOAQUABARCODE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-09-08
End date: 2011-09-07
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

DNA barcoding - a research approach that aims to simplify species identifications and accelerate the inventory of the world’s biodiversity - is being gradually implemented worldwide, but only recently a specific framework started to be organized at the European level. Luso-AquaBarcode aims to implement DNA barcoding into aquatic biodiversity research in Portugal, thereby standing at the forefront of the activation of this approach in Europe, and acting as a model project at the European level. Given its large, diverse and rich EEZ, Portugal is an ideal country within Europe to implement this project. With the introduction of the EC’s Water Framework Directive, there will be greater demand for tools to expedite macrobenthos monitoring. This proposal also aims to prime the development of DNA barcoding-based tools for species identification in marine and freshwater macrobenthic communities. This proposal constitutes an objective capitalization of the research and management skills acquired by the fellow during his mobility programme at Bangor University, UK. Upon initiation of this project the fellow will have completed 5 years of Post-Doctoral activity, and therefore it is in an appropriate timing to start up a career as an independent academic. The fellow will be hosted by the Department of Biology at the University of Minho, Portugal, where he will be assigned to a starting academic position, and will be granted opportunity to lead his research group within the Centre for Molecular and Environmental Biology. Luso-Aquabarcode will provide the fellow with a significant head start for a swift integration in the institution and work environment while enabling him to expand current research endeavours. This will greatly contribute for the development of the fellow’s appointment into a permanent academic position. Hence, this proposal will be key for the development of a coherent professional project and to improve the fellows’ long-term career prospects.

Keywords: biodiversity inventory: systematics phylogeny taxonomy,ecological genetics,aquatic ecology,ecotoxicology,biodiversity status and trends,biogeography,molecular markers and recognition