Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Social complexity in Resource Management (SOCORM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-04-11
End date: 2013-04-10
Duration (months): 24.0
Total project cost (EUR): 207979.2
EU funding (EUR): 207979.2
Participants: 1
Project status: CLOSED

This research projects starts from the observation that in some instances, government intervention is effective in conserving renewable natural resources, such as fish stock, but not in others. We argue that government intervention does not take place in a vacuum, as sets of social norms may exist that govern resource use. In some cases these social norms promote sustainable harvesting strategies, but they may also aggravate overfishing if they are merely aimed at reducing costs of exploitation. Success or failure of government intervention depends crucially on how this intervention interacts with the local set of social norms. We hypothesize that these social norms are shaped by the state and dynamics of the natural resources and hence co-evolve with these resources. The key objective of this project is to analyze how decisions of resource users are influenced by the biological and institutional environment. Specifically, we aim to identify, first, under which conditions social norms of resource exploitation evolve; second, how quickly these social norms adapt and respond to environmental changes; and third, how government intervention interacts with these social norms. The execution of this research project is explicitly interdisciplinary and stimulates close cooperation between economists and biologists. We combine mathematical biology with economic modeling and behavioral experiments, to obtain a unique mix of methods allowing us to address the research topic. Our approach is innovative as we explicitly take into account that the institutional setting is not an exogenous constant, but over time, institutions are determined endogenously through the interplay between economic, social and ecological forces acting on the system. This research combines insights from behavioral and resource economics as it addresses under what circumstances formal government intervention can stimulate or crowd out self-regulation.

Keywords: natural resource economics,fisheries economics,marine ecosystems,fleet behaviour,socio-economics (fishery economy),social norms,evolution of cooperation,evolutionary game theory
Regulation of mitochondria-endoplasmic reticulum tethering by Parkin: implication for Parkinson’s disease (MITOFUSIN-PD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-03-01
End date: 2014-02-28
Duration (months): 24.0
Total project cost (EUR): 178101.6
EU funding (EUR): 178101.6
Participants: 1
Project status: CLOSED

Parkin, an E3 ubiquitin ligase and a Parkinsons's disease related gene, translocates to impaired mitochondria upon mitochondria intoxication and drives their elimination via autophagy, a process known as mitophagy. Mitochondrial pro-fusion protein Mitofusin (Mfn) was found to be a target for Parkin mediated ubiquitination. In absence of Parkin, Mfn fails to be ubiquitinated, thus accumulates in the mitochondria, leading to increased mitochondria fusion. The host laboratory discovered that Mfn2 has an additional role in tethering mitochondria to endoplasmic reticulum (ER), a structural feature essential for Ca2+ transfer between the organelles and Ca2+ dependent cell death. This project hypothesizes that Parkin dependent ubiquitination of Mfn is crucial in regulating mitochondria-ER tethering and neuronal survival. We therefore aim to (i) address whether impairment of Parkin-dependent Mfn ubiquitination affects mitochondria-ER tethering and death by Ca2+-dependent stimuli; (ii) identify a potential Deubiquitinase (DUB) enzyme opposing Parkin activity in the regulation of Mfn ubiquitination; iii) identify novel interactors of the PINK1/Parkin pathway, regulating Parkin translocation to mitochondria and therefore Mfn steady-state levels. This project will therefore clarify if ER-mitochondria tethering participates in the neurodegenerative pathways controlled by Parkin

Keywords: mitochondria,mitofusin,parkin,pink1,ubiquitination,tethering
Responsive Janus inorganic / polymeric hybrid particles and their self-assembly (JANUS HYBRIDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 246855.0
EU funding (EUR): 246855.0
Participants: 1
Project status: CLOSED

This project aims for the preparation and self-assembly of responsive Janus inorganic/polymer hybrid particles. Such particles will exhibit distinguishing properties and potential applications in various fields, such as materials assembly, catalysis, microelectronics, and bionanotechnology, by the integration of multiple properties, e.g. of the “soft” polymeric component, of the “hard” inorganic component, sensitivity to the environment, and the anistropy originating from two chemically distinct regions. This research will create a novel one-pot method of producing series of these responsive Janus hybrid particles in large quantities by combining inner phase separation inside droplets with a sol-gel process. Furthermore, other functional moieties (e.g. adamantane(Ad), b-cyclodextrin (CD)) can be integrated into the Janus hybrid particles for improving their function. By controlling their morphology and structure, tuning their response to the environment, the properties of these particles will be investigated in detail, such as stimuli-responsive properties and the hydrophilic-oleophilic transition. In particular, the self-assembly behavior of these particles will be studied to great detail, such as the aggregation/disaggregation behavior, self-assembly induced by the CD/Ad complementary interaction pairs, superparticle structure, and self-assembly at interfaces. Finally, this proposal will explore the application of these Janus hybrid particles in the areas of stabilizing emulsions and on-off catalytic reactions. In the latter case, their switchable catalysis will be investigated.

Keywords: janus particles,responsive particles,hybrid particles,self-assembly,on-off catalysis
Financial Markets and Regulation: A Genetic Programming Approach (FIMAGP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-06-01
End date: 2012-09-30
Duration (months): 16.0
Total project cost (EUR): 190306.67
EU funding (EUR): 190306.67
Participants: 1
Project status: CLOSED

This project contributes to the understanding of the impact of financial regulation on securities markets through the development and application of an interdisciplinary approach which combines finance, economics and computer science to study order book and OTC markets. Our research supports regulators in forecasting and quantifying the effect of regulations. The insights gained in this project are highly relevant for policy makers as European competitiveness and growth can be negatively affected if regulations are poorly designed. Despite a dearth of scientific insight into the effects of regulatory measures, short sale bans and financial transactions taxes to curb `speculation’ have strong political support in Europe. On the market design side, OTC markets, whose lack of transparency is believed to have deepened the financial crisis, are under scrutiny with the aim to centralise trade. We study microstructure models where investors and security traders submit orders or write contracts to adjust their asset holdings over time. Trader behaviour is represented by computer programmes which process information. We identify behavioural equilibria through genetic programming which exerts evolutionary pressure to successively improve the traders' decision-making abilities until abnormal returns are eliminated. In these equilibria of behaviour and market dynamics, traders are optimally adapted to the institutional and regulatory setting. Results are obtained on the impact of regulatory measures on market stability (excess volatility and crashes), microstructure properties (market quality, price discovery) and the behaviour of investors and traders (asset allocation, skills) which are highly relevant to the understanding and prevention of market breakdowns and financial crises. The models and results will be published as a book to promote this newly established field. We will make the software available as open source code to ensure verifiability of the results.

Keywords: financial markets,financial regulation,market microstructure,order book markets,investment and trading decisions,bounded rationality,genetic programming,evolutionary finance
Reconstructing dinosaur/bird locomotor evolution: 3-D track simulation and X-ray validation. (TRACKEVOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2012-01-09
End date: 2015-01-08
Duration (months): 36.0
Total project cost (EUR): 239221.6
EU funding (EUR): 239221.6
Participants: 1
Project status: CLOSED

The evolution of birds from their dinosaur ancestors represents one of the most important and widely used examples of evolution available from the fossil record. Within this dinosaur-bird lineage, the evolution of bipedal locomotion has proven to be an intensely active area of research. Most of this research has taken an almost exclusively osteological approach, but while the fossilised skeletons of extinct animals can tell us much about their anatomy and palaeobiology, it is fossilised tracks that represent our only direct record of limb kinematics and animal locomotion. A fossil track represents the only direct record of limb motion, being the result of an interaction between an animal’s foot and a substrate. Track morphology is completely determined by substrate consistency, limb kinematics and kinetics, and foot morphology. By reverse engineering the process of track formation, information can be obtained pertaining to the locomotion of the track maker. The proposed research aims to investigate the effects of differing limb motion on track formation, in an attempt to understand locomotor evolution throughout the 230 million year evolutionary history of theropods (including modern birds). This will be achieved by marshalling state-of-the-art methods including bi-planer x-ray visualisation in order to physically model tracks. A virtual ‘track simulator,’ based on the discrete element method for modelling granular substrates will then be developed to explore in detail the effects limb motion has upon track formation. This knowledge will then be applied to the fossil record to observe any changes attributable to limb kinematics and locomotor evolution through time.

Keywords: natural sciences,palaeozoology,3 d modelling
Early Confucian philosophy in the light of the Guodian manuscripts (GUODIAN MANUSCRIPTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 223280.0
EU funding (EUR): 223280.0
Participants: 1
Project status: CLOSED

In 1993, a bundle of bamboo-slip manuscripts were unearthed in a tomb, dated sometime between the late fourth and the early third century B.C., in a village named Guodian, in China. In addition to other written materials, the archaeological excavation revealed an important number of Confucian treatises, many of them without transmitted counterpart. Photographs and transcription of these texts became available in 1998 and have generated an intense interest among scholars of early Chinese intellectual history and philosophy. These manuscripts provide valuable new insight into the formation and the evolution of the Confucian doctrines that became central to the later tradition and allow reshaping the development of some of the most important intellectual debates of the Warring States period (476-221 B.C.). My research project will provide a comprehensive philosophical reading as well as an annotated translation into Spanish of this invaluable new written source concerning the development and evolution of early Confucian philosophy. My research on the Guodian manuscripts will be articulated around the following problems and concepts: (i) the different conceptions on human inherent characteristics (xing 性); (ii) the debates on the morally ambivalent orientation of human natural condition; (iii) the links between natural conditions (zhi 質) and virtuous accomplishments (de 德); (iv) self-cultivation techniques (xiu shen 修身); (v) the relationship between human inherent characteristics and external things or events (wu 物); (vi) the discourses on the height of music (yue 樂) and ritual (li 禮) in the formation of a sage person; (vii) the role of the heart-mind (xin 心) as the chief mechanism of control in the human body; (viii) the controversy on emotions (qing 情) and their crucial role in affect regulation and consequently in social control.

Keywords: philosophy,history of philosophy,philosophical anthropology,oriental philology,humanities
The use of fragment-based drug discovery to develop novel small molecules that modulate the BRCA2-RAD51 interaction for the treatment of cancer (BRCA2-RAD51)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-03-01
End date: 2013-02-28
Duration (months): 24.0
Total project cost (EUR): 201049.6
EU funding (EUR): 201049.6
Participants: 1
Project status: CLOSED

The proposed research is to develop a small molecule as drug candidate compound for the treatment of cancer. We will use fragment-based methods to disrupt the protein-protein interaction between the human recombinase RAD51, and the hub protein BRCA2. This interaction is essential for DNA repair by homologous DNA recombination (HDR), a key cellular pathway involved in the resistance of cancer cells to ionizing radiation and radio-mimetic drugs. The target site (i.e. Velcro pocket) is unique to RAD51 and binds the LFDE tetrapeptide motifs in BRCA2. A suite of biophysical techniques will be used to identify small chemical fragments that specifically bind to the Velcro pocket. Fragment hits will be developed by structure-guided synthesis into more potent inhibitors that disrupt RAD51-BRAC2 interaction impairing the HDR process. We foresee that these small molecule inhibitors will have broad applicability in combination with existing cancer treatments. Moreover it can be anticipated that a small molecules that target only the Velcro site of RAD51, thereby preventing interaction with BRAC2 protein without precluding RAD51 oligomerization, will be valuable chemical tools to uncover different mechanistic aspects of the HDR process in cells.

Keywords: fragment-based drug discovery,cancer,rad51,homologous dna repair,synthetic chemistry,protein-protein interaction,small molecules inhibitors,structure-based design
Online Communication Analysis: Methods for Multimodal, Networked Communication (ONCOA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Germany
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 141148.4
EU funding (EUR): 141148.4
Participants: 2
Project status: CLOSED

The overarching objective of the proposed project “Online Communication Analysis: Methods for Multimodal, Networked Communication” (OnCoA) is to develop an interdisciplinary methodological and theoretical approach to online communication in the field of media and communication studies that aims to provide applicable solutions for current and future demands in digital media and communication analysis. The term ‘online communication’ comprises here any communicative interaction/action on and by means of the Internet. Therefore, the project focuses on methods and underlying theories/paradigms regarding the analysis of multimodal, networked online communication where text, audio, pictures and video represent different albeit joined linguistic modes that build coherent content. Hyperlinks represent another linguistic mode that turns static and linear text into dynamic networked communication where both the text producers and readers become interchangeable actors. The innovative nature of the project lies in its interdisciplinarity, aiming at an integration of both social sciences-driven and media informatics-driven approaches in online communication research. The methodological, theoretical, and technological challenges of this research arise out of the multimodal nature of digital communication (e.g. websites or weblogs with text, audio, and video content). Additionally, the multitude and networked (i.e. hyperlinked) nature of online communication demand a revision and amplification of existing approaches to online communication analysis, specifically regarding the traditional methods in social sciences, such as content analysis.

Keywords: social sciences,online research methods,multimodal analysis techniques,media informatics,online-journalism
STUDIES ON THE BACTERIAL STRESS RESPONSE AND STRESS-INDUCED CROSS-RESISTANCE (BACTERIAL STRESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-09-15
End date: 2013-09-14
Duration (months): 24.0
Total project cost (EUR): 167065.6
EU funding (EUR): 167065.6
Participants: 1
Project status: CLOSED

Many bacteria, including human and animal pathogens can acquire a high-resistance state as a consequence of exposure to stress. Since in their natural environments, bacteria seldom encounter conditions that allow exponential growth, understanding the mechanism/s behind stress-induced cross-resistance is of uttermost importance for the control of bacterial populations. In particular, the epidemiology and virulence of many human, animal, and plant pathogens appears to be related to stress-induced cross-resistance and phenomena such as biofilm formation appear to be the direct consequence of exposure to environmental stress. Therefore, understanding these bacterial survival strategies has important medical and economical implications. The research proposed here aims at the characterization of the molecular details behind the strategies used by two different Gram negatives, Escherichia coli and Vibrio anguillarum, for the development of stress-induced cross-resistance. E. coli is the organism for which the most detailed picture of cellular physiology exists and has been commonly used as a model for the study of the bacterial protein synthesis and the response to stress. My previous research with this organism has uncovered an important link between the ribosome and the process of stress-induced cross-resistance. The molecular details of this phenomenon will be explored in Specific Aim I. V. anguillarum is the fish pathogen which causes vibriosis, a devastating disease affecting aquaculture. Therefore, there exists high economic interest in developing methods for the control of this bacterium. Increased virulence in V. anguillarum appears to be related to iron deficiency, a common type of environmental stress. The goal of Specific Aim II is to study the cellular response to iron deficiency as well as the molecular details of iron uptake in V. anguillarum, so that strategies for its containment can be designed.

Keywords: ribosome,siderophore,iron deficiency,cross-resistance,environmental stress,kasugamycin,antibiotic resistance,rrna,translation
Real-time Assortment Customization for Products with Dynamic Content: Theory and an Application to Interactive TV (ASSORTMENTCUSTOMIZE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-04-01
End date: 2013-03-31
Duration (months): 24.0
Total project cost (EUR): 185540.8
EU funding (EUR): 185540.8
Participants: 1
Project status: CLOSED

In many industries, firms give consumers more choice options than they can choose, in a phenomenon that has been described as the paradox of choice. When products are created and updated very rapidly, the problem is worse e.g., consumers often have hundreds of cable TV programs to choose from. This project proposes a method to optimally customize the assortment of products shown to consumers according to each consumer' s individual characteristics. The method first identifies product category membership for each product, and looks at consumer historical data to infer consumer’s style. Given product categories, consumer style, product price and cost, the method uses dynamic programming to identify the best shortlist of products to be offered to each consumer. Next, the consumer makes a decision (to choose or not a product from the list). The decision is then used to update the optimization algorithm. The method proposed in this project will be tested in one industry in particular (cable TV), but it will be general enough to be applicable to others. The method is based on cutting-edge optimization technology. This knowledge was developed at MIT and published by the applicant along with MIT senior professors in the best journal of the marketing field (Marketing Science). The applicant’s 2009 paper was the finalist of the prestigious John D.C.Little Award, and received Elsevier's Citations of Excellence award. It was published as the leading paper of its issue, with commentaries by leading scholars. The overall research strategy is to develop and solve the model, gather empirical priors from a field survey, run empirically-based simulations to obtain a proof-of-concept, and then empirically test the algorithm in the field. The implementation of the project includes the creation of a lab at the EUR with graduate students. The EUR will give full support including reduced teaching load, computing resources, mentoring, research budget and students.

Keywords: interactive tv,dynamic programming,assortment customization,automated marketing,multi-armed bandits.