Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Explicitly Normalized ImaGing MAss Spectrometry (ENIGMAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 183805.8
EU funding (EUR): 183805.8
Participants: 1
Project status: CLOSED

Imaging Mass Spectrometry is a rapidly developing technique that uses spatially resolved proteomic techniques to investigate a tissue’s biomolecular content. Imaging MS of pharmaceuticals has demonstrated that relative quantitation can be obtained if the MS response factors are known. However MS response factors for peptides and proteins are highly dependent on their exact nature. Despite it being acknowledged as the single biggest factor limiting the clinical application of the technique, to date it has remained an enigma how imaging MS analyses may be explicitly normalized to enable relative quantitation because it would require the relative response factors to be determined for every peptide/protein. Here I will develop a methodology for the explicit normalization of every protein detected during imaging MS experiments. This will utilize the recently released SILAC mouse to create a reference standard in which all lysine residues are replaced with 13C6-lysine. Tryptic digestion of SILAC protein extract creates tryptic peptides containing a single 13C6-lysine, which can be used as a reference standard for the 12C6-lysine containing peptides created by on-tissue digestion of normal mouse tissue. Ultrahigh mass resolution imaging MS will be used to ensure all tryptic peptides, and their 13C6-lysine reference standards, are resolved enabling the images of all tryptic peptides to be normalized using their own isotopically labelled analogues. The quantitative capabilities will be determined for every tryptic peptide ion detected from mouse brain tissue. The capabilities of this ENIGMAS strategy (Explicitly Normalized ImaGing Mass Spectrometry) will be used to investigate the spatial and temporal evolution of the proteome perturbations that follow migraine. Multiple measurement repeats and multiple animals in each group will provide the first measure of statistical significance for imaging MS based molecular histology, a crucial step toward its clinical application.

Keywords: quantitative proteomics,imaging mass spectrometry,clinical bioanalysis,clinical chemistry,chronic diseases,migrane,neurosciences
New Generation of NiAl-Based Eutectic Composites with Tuneable Properties (NECTAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-09
End date: 2016-04-08
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Structural metallic materials for applications in turbine blades are attractive not only from industrial, but also from environmental and socio-economical standpoints. The Ni-based superalloys have been the state of the art materials for this application. Nevertheless, ever increasing working temperatures of the components need further alloy development. Therefore, intermetallic compounds have been considered as promising candidates to substitute some of the Ni-based superalloys. The major objective of the project is to design, develop, understand and model the new class of NiAl-based in situ composites with tunable properties for high temperature services. A novel synergetic approach combining state-of-the-art computational thermodynamics and state-of-the-art alloy design, processing and characterization, will be presented. On one hand, advanced computational thermodynamic tools will be used to create and optimize thermodynamic and mobility databases, which will be subsequently used for constitutional and phase equilibrium calculations. In parallel, diffusion and phase field models will be developed to model the solidification process. On the other hand, a combination of sophisticated alloy design and processing will be employed to understand the solidification behavior and control the microstructure. Based on this knowledge the microstructure-property relationship will be established and alloys with superior properties will be tailored. Besides the contemporary concepts of alloy design and processing, some novel aspects will be introduced as well. For example, the use of pseudo-binary eutectic trough concept to systematically change the volume fraction of the reinforcement will be presented for the first time to the scientific community. This will contribute to development of other classes non-structural eutectic materials as well. Also, methodical microstructure control by using gradient ingot method also present innovative features in modern alloy development.

Keywords: nial,intermetallics,eutectic growth,solidification processing,thermodynamic modelling,microstructure prediction,mechanical properties
SOFC Auxiliary Power In Emissions/Noise Solutions (SAPIENS)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: European organisations area,Spain,Poland,United Kingdom,United Kingdom,Austria,Germany
Call:  (FCH-JU-2011-1, 2011)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 2369507.2
EU funding (EUR): 1591590.0
Participants: 7
Project status: CLOSED

This project aims to design, optimise and build several 200W mSOFC stacks and to integrate them into hybrid power systems comprising the fuel cell, a battery and appliances found in a recreational vehicle (RV). Additional components of the system are a gas processor to clean up the autogas propane fuel plus other equipment for electrical, mechanical and control balance of plant (BOP). All these components will be constituents of an entire fuel cell power generator which will first be tested in the lab and, after further optimisation and miniaturisation, in an RV platform. The project is primarily aimed at the RV platform from Autosleepers, an SME based in the UK, but other applications such as boats, ambulances and environmental testing vehicles will also be studied. Propane was chosen as the the fuel because of its superior energy density compared to hydrogen and methanol, and also because it is the generally preferred fuel for auxiliary systems on RVs, such as cookers, fridges and water heaters. Autogas propane is widely available at filling stations throughout Europe. The SOFC was chosen because it can convert propane while also providing low noise, low emissions and heat for hot water supply. The overall objectives are: Develop the fuel cell power supply to fit the RV Test the Autogas propane fuel Study the needs of the market to reduce the risks of commercialisation Improve the SOFC in terms of materials, lifetime, performance and costs Innovate on noise reduction and emissions Provide several fuel cells for testing optimisation and proving To test long term durability and cycling for obtaining approvals To disseminate by getting real users to apply the new device and report results across Europe Impact will be substantial because the general public will be using these RVs. Also three special conferences will be organised to disseminate information, ten refereed publications will be submitted and patents will be published on the innovations.

Keywords: sofc,portable fuel cell,rv application
High Pressure Hydrogen All Electrochemical Decentralized RefUeling Station (PHAEDRUS)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: United Kingdom,Norway,Germany,Netherlands,Germany,France,Germany,Netherlands,Netherlands,Denmark
Call:  (FCH-JU-2011-1, 2011)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 6309832.0
EU funding (EUR): 3566343.0
Participants: 10
Project status: CLOSED

PHAEDRUS addresses the complete scope and objectives of Topic SP1-JTI-FCH.2011.1.8. A new concept and new technologies for a hydrogen retail refuelling system are developed. The major objective is to develop and validate a new concept for 70 MPa hydrogen refuelling retail stations by showing the applicability of electrochemical hydrogen compression technology in combination with a PEM electrolyser, storage units and dispensing system. The use of electrochemical hydrogen compression technology is a step change in both the efficiency and cost of ownership of an integrated hydrogen refuelling system. The applicability will be demonstrated in a fuelling system producing 5 kg hydrogen per day, while a design is made for a fuelling system capable of producing 200 kg hydrogen per day. Safety aspects, efficiency and economic viability of the system’s components will be analysed and validated as well. The targeted HRS infrastructure will have a modular dispensing capacity in the range of 50-200 kg per day, and will be fit for early network roll-out from 2015 onwards to 2020. Various consortium members are actively involved in working groups where relevant standards like SAE J2601, SAE J2799, CSA TIR 4.3, ISO TC 58/SC3 and ISO TC197 are being developed. An Advisory Board will review the progress with respect to international developments and will act as an interconnection to efforts in other Member States, Asia and the United States. The project is scheduled for 3 years and can be regarded as phase one of a two-step development. In the first phase technology will be developed, a complete Hydrogen Refuelling System design is made for 200 kg/day capacity, and validated on a 5 kg/day scale. Subsequently in phase two the technology will be demonstrated in a scalable 200 kg/day Hydrogen Refuelling System. The consortium encompasses the complete value-chain for an innovative hydrogen refuelling station; from a hydrogen producer to the automotive industry.

Keywords: electrochemical compression technology,hydrogen compressor,hydrogen refuelling station,700 bar hydrogen
New Methods For Forecast Evaluation (NEW FORECAST METHODS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Forecasting is a fundamental tool in Economics, Statistics, Business and other sciences. Judging whether forecasts are good and robust is of great importance since forecasts are used everyday to guide policymakers' and practitioners' decisions. The proposal aims at developing three tools for improving the way forecasts are evaluated as well as establishing a research network on time series econometrics and forecasting, essential for my permanent integration at the host institution and the successful continuation of my research career in Europe. The three tools that the proposal plans to develop are aimed at resolving three important practical issues that researchers face in practice. The first project, titled “Out-of-Sample Forecast Tests Robust to the Choice of Window Size”, aims at developing methods to evaluate forecasts that are robust to the choice of the estimation window size. The choice of the window size has always been a concern for practitioners, since the use of different window sizes may lead to different empirical results in practice. The second project, titled “Forecast Optimality Tests in the Presence of Instabilities”, aims at developing tests for forecast efficiency that are robust to the presence of instabilities. Existing techniques are invalid in the presence of instabilities. The third and most ambitious project, titled “Why Do We Do Forecast Tests?”, aims at understanding the relationship between traditional in-sample tests and forecast evaluation tests. In order to successfully complete these projects in Europe, where I have been offered a job starting in January 2012, funding to visit co-authors in the US, present my research projects to conferences, hire research assistants and organize conferences and host co-authors will be essential. These activities will contribute to the creation of a research network benefiting the host institution, policy institutions in Europe (e.g. the ECB) as well as students, practitioners and researchers.

Keywords: econometrics,forecasting,time series econometrics,model evaluation
IMprove PEMFC with Advanced water management and gas diffusion Layers for Automotive application (IMPALA)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: France,Germany,Switzerland,European organisations area,France,Germany,Netherlands
Call:  (FCH-JU-2011-1, 2011)
Start date: 2012-12-01
End date: 2015-11-30
Duration (months): 36.0
Total project cost (EUR): 5081586.8
EU funding (EUR): 2640535.0
Participants: 7
Project status: CLOSED

The purpose of the IMPALA project is to manufacture improved GDL to increase performance (up to 1 W/cm²) and durability of PEMFC for automotive applications. Two approaches will be followed: i) Homogeneous GDL will be modified to ensure a better water management on anode and on cathode side (formulation of the MPL, wettability, stability of the hydrophobic treatment, hydrophilic layers, and conductive additives). Most of these modifications should be transferable to industry. ii) More innovative non uniform GDL will be manufactured to adjust their local properties to the non uniform local operating conditions of a PEMFC (gradients of porosity and of wettability, patterns of hole). This is a higher risk approach as some modifications could be difficult to transfer to industry but the improvements should be higher and lead to breakthrough GDL. This technological work will be supported by a deep water management analysis combining the most advanced two-phase models (Pore Network Modelling) and the most advanced experimental diagnostics (liquid visualisation by X-Ray, local instrumentation). This will allow having a much better understanding on water management and on the link between main properties of GDL (thickness, pore size and wettability distribution…) and their performance in PEMFC. This will ensure important scientific progress and provide recommendations for design. The project is focused on standard automotive conditions but special attention will be paid to ensure the improvements will be valid for higher operating temperatures and different stack design for back-up applications. The consortium gathers the necessary international complementary leading expertise to reach the project targets: INPT: two-phase modelling, PSI: X-Ray visualisation, JRC: modelling and tests, CEA: performance modelling, tests and modification of GDL, DLR: characterization, SGL: manufacturing performing GDL, and NEDSTACK: stack tests for automotive and back-up application.

Keywords: gas diffusion layer (gdl),proton exchange membrane fuel cell (pemfc),water management
Automotive pemfc Range extender with high TEMperature Improved meas and Stacks (ARTEMIS)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: France,Netherlands,Spain,Italy
Call:  (FCH-JU-2011-1, 2011)
Start date: 2012-10-01
End date: 2015-12-31
Duration (months): 39.0
Total project cost (EUR): 2822692.04
EU funding (EUR): 1747884.0
Participants: 6
Project status: CLOSED

ARTEMIS is a collaborative project whose aim is to develop new high temperature PEMFC MEAs for operation up to at least 130 °C, and preferably 150 to 180 °C, and their validation in a stack for automotive application as a range extender. There is increasing industrial interest in developing HT-PEMFC systems in conjunction with Diesel or methanol-reformer to continuously charge batteries onboard of automotive vehicles, thus extending the range to several hundred kilometers, using the existing infrastructure for hydrocarbon fuels. HT-PEMFC systems are being developed commercially for backup-systems in remote areas or developing countries where a long operation time is required when the grid fails. Hydrogen supply for those applications is, in the present infrastructure scenario, rather difficult and expensive, leading to the combination of reformers with HT-PEMFC as an attractive option. High temperature fuel cells offer advantages for the overall system. HT-PEM fuel cells require less balance of plant components and thus have reduced ancillary loads, and they offer high tolerance to CO and other pollutants, meaning that either lower quality hydrogen can be used on an onboard reformer integrated to use readily available hydrocarbon fuels (gasoline or diesel in the case of range extender to an ICE, or others, bioethanol for example in the case of a range extender to a battery). The purpose of ARTEMIS is to develop and optimise alternative materials for a new generation of European MEAs which could be integrated into a 3 kWe high temperature PEMFC stack, while reducing cost and increasing durability. The MEAs will be based on new and alternative polybenzimidazole type membranes and improved catalytic layers providing low catalyst loading and high efficiency at high temperature as well as a high tolerance to pollutants. The MEAs should offer long and stable properties under various conditions of operation relevant to the range extender application.

Keywords: automotive,meas,pemfc,stack,high temperature fuel cell,new materials,catalyst materials,carbon clothe,metallic bipolar plates,composite graphite bipolar plates,range extender
THE EPIGENOME OF BREAST CANCER STEM CELLS (EPIGBRCASTEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed project aims to elucidate the epigenome of cancer stem cells in breast tumours in an effort to shed some light into the pathophysiology of these cells and with the ultimate goal of developing therapeutic schemes that target them specifically. Accumulating evidence suggests that only a subset of cancer cells, the CSCs, have the ability of self-renewal and can support cancer progression, while the rest of the tumour cells have only limited proliferative capacity and do not significantly contribute to tumour growth. Consequently, successfull anti-cancer treatments should seek to specifically eradicate these cells and not target the bulk of the tumour. To this end, it is critical that we reveal and study the unique genetic and epigenetic characteristics of CSCs. Epigenetic mechanisms are believed to drive the differentiation of CSCs to less malignant cells. Thus, differences in their epigenome may be accountable for their different tumourigenic potential. In the first aim of the proposed project we will perform analysis of the epigenome (DNA methylation, post-translational histone modifications and small non-coding RNAs) of breast CSCs and non-CSCs by next-generation sequencing. The data generated from these experiments are expected to reveal the unique epigenetic signature of breast CSCs. This information will be used in the second aim of this project to develop and validate an in vitro cell culture system that will mimick the in vivo state of CSCs. This system will be used for screening drugs that specifically target epigenetic mechanisms in CSCs, as opposed to current epigenetic treatments for breast cancer that target the phenotypic characteristics of the bulk of the tumor. The proposed project is expected to contribute significantly in a new exciting field, that of cancer stem cells, and to help the applicant reintegrate in the European research community after training and working at top Institutes of USA and Canada for many years.

Keywords: health sciences,epigenetics,breast cancer stem cells,anticancer therapy
Genetic determination of early male parr maturation in Atlantic salmon natural populations (GENEARLY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Understanding the relative importance of short and long term evolutionary processes in species adaptation is central in evolutionary and ecological genetics because it helps understanding how and how fast species respond to environmental changes. In addition, intraspecific variability is of paramount importance for species adaptation to global changes. Atlantic salmon, Salmo salar, provides important ecosystem services but is a vulnerable species spanning its life cycle between the freshwater and the ocean ecosystems, two habitats particularly sensitive to human impacts and global changes. This species is renowned for its life history variability in particular for showing high variation in the age at maturity, especially for male individuals that can mature early before the seaward migration. This phenomenon called early male parr maturation (EMPM) is especially frequent in southernmost salmon populations pointing to an environmental effect on this reproductive behavioral trait. Previous studies had also showed that this phenotype may be under partial genetic control whose precise mechanism remains yet unknown. In the proposed research project GenEarly (Genetic determination of early male parr maturation in Atlantic salmon natural populations) we will combine behavioral ecology, quantitative genetics and population genomics approaches and use the state of the art in sequencing technology to shed new light on the genetic determinism and the genomic architecture of the EMPM phenotype in Atlantic salmon natural populations. The project will produce new understanding about genetic potentialities and constraints for reproductive behavior evolution in face of global changes with a particular focus on improving evolutionary trajectory predictability and conservation practices. Furthermore, scientific and technical qualities of the project will guaranty the successful start of the applicant career among one of the world leading research institute in biological sciences.

Keywords: alternative reproductive strategy,early maturation,salmo salar,atlantic salmon,behavioral ecology,quantitative genetics,population genomics,transcriptomic,next-generation sequencing.