Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative design and implementation of next-generation Point-of-Care CAR-T (InnoCAR-T)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Belgium,Spain,Germany
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2952418.63
EU funding (EUR): 2618856.0
Participants: 10
Project status: SIGNED

InnoCAR-T is a Doctoral Network designed to provide training and carry out breakthrough research on the high impact field of Chimeric Antigen Receptor (CAR) T cell immunotherapy in a carefully integrated academic and inter-sectoral programme. We aim to develop next-generation CAR-T therapy and deliver a set of young researchers uniquely qualified for a career in academia and/or industry. CAR-T cell therapy represents a revolutionary advance in oncology, particularly for B cell lymphoma patients. However, long-term response is still restricted to ~50% of patients, with resistance being even more prominent in other cancers. Thus, additional innovations to overcome resistance are needed to improve CAR-T responses. Unfortunately, the currently centralized production of CAR-T hampers rapid innovation and associates with prohibitive costs, long vein-to-vein time, and poor carbon footprint due to inter-continental delivery. InnoCAR-T aims touse innovative academic and industrial concepts to address these issues by 1. developing innovative manufacturing solutions for CAR-T production at local academic hospitals and 2. developing the next-generation of more effective CAR-Ts. At the core of InnoCAR-T is its training objective to offer a cutting-edge multidisciplinary training programme. Herewith, outstanding young scientists can generate breakthrough ideas and assume leading positions in academia and industry. The training programme includes an array of disciplines, ranging from biomedical sciences (e.g. immunology, CAR engineering, gene-editing), physical sciences to mechanical engineering. Industrial partners are central to the programme and provide pivotal expertise on how to translate scientific discoveries into commercial reality. Inter-sectoral partners will host Doctoral Candidates, provide key secondments and network-wide training events. Further, InnoCAR-T will foster long-term multi-disciplinary research and bilateral co-operations between academia and industry.

Keywords: car therapy,academic,immunomodulation,nanodelivery,crispr cas9 gene editing,spatial transcriptomics car therapy,academic,immunomodulation,nanodelivery,cas9 gene editing
FUlly Numerical strategY for SUrrogate modelling of Monopile Offshore wind turbines (FUNnY-SUMO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Croatia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2026-01-31
Duration (months): 26.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

The main objective of FUNnY SUMO is to develop a highly accurate 3D numerical model of monopile offshore wind turbines (MOWT) considering simultaneously all the environmental loads (current + waves + wind), to be used as a high-fidelity model for the definition of a surrogate model that enables the application of data-driven design in the next generation of MOWTs. This project will set the playground for the next generation of offshore data-driven wind turbines and will have an impact on the European industry while boosting the candidate’s applied-research career. The CFD and Surrogate models will be validated with a recent experimental study by FUNnY SUMO’s secondment. The method will be divided mainly into two parts; First is CFD modeling, where a CFD model will be developed for each load acting on the MOWT, and then integration in a complete CFD model of the current + waves + wind effects on the MOWT, aiming at 80% accuracy relative to experimental measurements. The second is developing three Surrogate models using the CFD results. This project is divided into 5 Work Packages (WPs) to efficiently achieve the specific objectives of this proposal. WP1 deals with management, The Specific objectives will be addressed within WP2–4, where WP2 considers Meshing and model settings, WP3 is the validation of numerical models, WP4 deals with the Surrogate model definition, and WP5 addresses the Dissemination activities. The results of the project will facilitate Europe’s energy independence by bolstering innovative design processes in MOWTs based on the application of surrogate models (SM). Furthermore advanced MOWTs will be manufactured and deployed in the EU’s geographical area.

Keywords: offshore wind turbine,cfd,numerical modeling,aerodynamic and hydrodynamic loads
Alternative sources for high added value food and/or feed ingredients (SYLPLANT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: France,Estonia,Norway,Germany
Call: Alternative sources for high added value food and/or feed ingredients (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 22736733.46
EU funding (EUR): 13909015.08
Participants: 17
Project status: SUSPENDED

The world is facing the daunting challenge of increasing and improving the quality of its food production to match its population growth, and simultaneously of making its food production system more sustainable if it wants to reach the goals set in the Paris Agreement on climate change (more than a quarter of greenhouse gases are generated by the food production system). In the EU, an additional challenge comes up since about 75% of protein production is imported. This dependence on imports represents a weakness as supply chain disruptions have become much more common, due to pandemic crises or geopolitical upheavals. ARB has developed a high-quality protein ingredient, called SylPro, that addresses all these challenges. It valorises under-used feedstock (such as agricultural or forestry residues) as raw material and harnesses the power of a proprietary yeast to produce a protein rich ingredient that can be used directly for human food or animal feed. ARB’s technology can thus produce proteins both locally and on a very large scale since lignocellulosic material and agricultural side streams are available in huge quantities. Thanks to a robust and efficient process, it also has a low environmental footprint, making its product one of the protein ingredients with the lowest CO2 emissions. SYLPLANT is building on the success of its demonstration program SYLFEED, a 4-years innovative collaborative project financed by BBI-JU (2017-2021).For this project, ARB proposes to move to the next step, building its first-of-a-kind commercial plant with a capacity of 10 kt/year of SylPro and developing market applications with various partners. Upon completion, SYLPLANT will then deliver an industrial plant producing a high-quality protein ingredient, innovative market products in the food, petfood and aquafeed sectors, and a roadmap for building larger plants combining ARB and FIB’s technologies, making the vision of creating food from under-used and local resources a reality.

Keywords: flexible feedstock,innovative process,bioeconomy,human nutrition,animal nutrition
Pressurized Efficient Alkaline EleCtrolysEr (PEACE) (PEACE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,Italy,Netherlands,Czechia,Denmark
Call: Development of low temperature water electrolysers for highly pressurised hydrogen production (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 2504965.0
EU funding (EUR): 2504964.75
Participants: 7
Project status: SIGNED

Among the different electrolysis technologies, AEL is very competitive, because of its low investment costs and good scalability. The levelized cost of hydrogen (LCOH) produced by AEL can be reduced by enhancing the efficiency, maximal current densities and by enabling better integration with downstream processes. A well-tuned design of high-pressure stack and system improve the performance and overall efficiency, by eliminating the need for further compression for downstream processes. As compressors for hydrogen represent a significant share of CAPEX and OPEX of electrolysis systems, those can be reduced or eliminated. In this project, the consortium will design and develop an AEL system demonstrator >50 kW, capable of operating at a pressure up to 90 bar, achieved by a novel concept in which the pressurization is done at two stages: by applying up to 60 bar hydraulic pressure using a pressure vessel in which a stack operates at additional 30 bar, resulting in up to 90 bar gas pressure. Integrating advanced components, innovative design, and optimizing operation strategies, through modelling and experimental testing, a system with an efficiency of 70 % (LHV) at a current density of 1 A/cm2 will be demonstrated. With this technology an AEL system will be provided that may lead to major cost reduction of green hydrogen production. The main scientific aims of the project are further supported by sustainability and circularity aspects as well as dedicated outreach activities, and jointly addressed by 2 medium-sized enterprise (SMEs), 4 R&D centres with established expertise in alkaline stack, system and Life Cycle Assessment (LCA), and one of the largest hydrogen production and utilization companies in the world. Lastly, use cases and the concept of the integrated plant will be proposed. Together, the new developments will target a technology breakthrough with a clear commercial perspective, placing Europe at the lead of highly pressurized AEL technology in 3 years.

Keywords: alkaline electrolyzer,pressurization,efficiency,levelized cost of hydrogen
Wafer-scale platform for Photonic Programmable Multipurpose Integrated Circuits (PHORMIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Belgium,Sweden,Ireland,France,Israel,Spain,Germany,Latvia
Call: Advanced Photonic Integrated Circuits (Photonics Partnership) (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 5594131.0
EU funding (EUR): 5594130.25
Participants: 11
Project status: SIGNED

PHORMIC establishes a European platform for next-generation programmable photonic chips with a low adoption threshold for product developers in diverse application domains. The PHORMIC platform consists of three tiers. The first tier is a 200 mm wafer-scale fabrication flow that augments an established world-class silicon photonics platform with transfer-printed III-V optical amplifiers, electro-optic materials in the form of molecular glasses, and compact low-power MEMS actuators. The devices are encapsulated in wafer-scale hermetically sealed cavities that will also be used for on-chip gas cells to calibrate the tunable lasers built in PHORMIC. The combination of high-speed silicon photonics, Pockels-based modulators, broadband optical gain and low-power MEMS tuners is a true enabler for new applications. The process flow will be supported by a design kit for building complex photonic circuits. The second tier supplements the photonic chips with modular packaging processes and driver electronics (including high-speed drivers), and the packaging and connectivity logic are integrated in the design kit. This provides a low-threshold entry point for building complex photonic chip-based systems with active control and programmability. The third tier builds on this to create a multipurpose programmable photonic processor, which can control the flow of light in an analogue way through a software interface. This chip, together with its electronics and programming framework, forms a true “photonics development kit”. This enables an off-the-shelf use model like that of electronic FPGAs, reducing prototyping time for new concepts from >1 year to weeks. The PHORMIC consortium has all expertise to establish a full supply chain, including a migration path to a European industrial 200 mm foundry. The application potential of the three tiers of the platform is validated through three demonstrators, in datacenter communication, sensing and mm-wave wireless beamforming. For each case, a custom-designed chip will be compared to the multipurpose photonic processor.

Keywords: silicon photonics,mems,lasers,programmable photonics,wafer scale
Parsing dopamine's learning and motor functions (RegionalDopamine)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: CLOSED

Appropriate selection of situation-appropriate behaviour requires both learning and motor control. Release of the neurotransmitter dopamine in the striatam is crucially involved in both of these processes. However, previous work investigated learning and motor functions of dopamine in isolation. To fully understand dopamine function and dysfunction, it is imperative to take both learning and motor control into account. Striatal dopamine release is thought to encode a reward prediction error, the discrepancy between expected and obtained outcome, as well as promote movement. Dopamine release optimises and drives behaviour by modulating the activity of striatal medium spiny neurons (MSNs) and their downstream neural pathways. Binding of dopamine to type-1 and type-2 dopamine receptor-expressing MSNs differentially modulate intracellular signalling cascades, increasing or decreasing phosphorylation of protein kinase A (PKA), respectively. Differential modulation of PKA activity is thought to underlie learning and motor control, ultimately driving behaviour. Importantly, dopamine’s influence on MSNs is functionally disparate between limbic, associative, and sensorimotor domains, and it is hypothesised that these regions differentially encode learning and movement. Here, I aim to discern the entanglement of dopamine functions by employing a powerful behavioural task that differentiates between learning and movement, while 1) simultaneously recording dopamine release in distinct striatal domains, and 2) recording the activity type-1 or type-2 MSNs using a novel, cutting-edge tool to detect real-time PKA activity. The complementary power of these innovations will enable me to drive forward the current understanding of dopamine’s function by combining state-of-the-art neuroscience techniques, elucidating the entanglement of dopamine in learning and motor control on behaviour.

Keywords: dopamine,voltammetry,motor control,reward prediction error,fibre photometry,go no go,rodent
Harnessing the cognitive and neurophysiological processes characterising the sleep onset period (CREADOZE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1995218.0
EU funding (EUR): 1995218.0
Participants: 1
Project status: SIGNED

Sleep often escapes us when we need it or intrudes when we would prefer to stay awake. What if we could control when we fall asleep? While our understanding of sleep has rapidly grown, what happens during the wake to sleep transition remains mysterious, potentially due to the widespread assumption that we are either awake or asleep. The current standard is to define vigilance states through coarse, physiological criteria that are visually assessed on fixed, 30s-epochs. In this framework, the sleep onset period (SOP) typically corresponds to the first sleep stage. Yet, this classification in discrete sleep stages fails to account for the gradual, dynamic changes observed in the descent to sleep, on the behavioral (reduced responsiveness to stimuli), subjective (dream-like experiences called hypnagogia) and cognitive level (decline in executive functions, enhanced creativity). To better understand how we transition from full vigilance to sleep, I propose to integrate, within the same framework the many dimensions of the sleep onset process. I hypothesize that the behavioral, subjective, and cognitive changes associated with the SOP are each reflected by specific neurophysiological signatures that are partially independent of sleep stages. I recently found candidate physiological markers for the different SOP dimensions. In CREADOZE, I will leverage on these findings to refine in space and time the neurophysiological signatures reflecting the processes which decline (behavioral responsiveness, executive abilities) and those which emerge (hypnagogia, creativity) during the SOP, using multimodal physiological recordings. I will explore how these markers fluctuate in relation to each other and identify potential factors influencing them (sleep pressure; sleep disorder). Then, I will use neurofeedback to train individuals to either resist or embrace sleep. If successful, this proposal will open the possibility to harness the sleep onset period depending on one’s needs.

Keywords: sleep sleep onset creativity
Improving GreeN Innovation for the blue revoluTION: new tools and opportunities for a more sustainable animal farming (IGNITION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Portugal,Norway,Denmark,Belgium,United Kingdom,Italy,Spain,Ireland
Call: Biosecurity, hygiene, disease prevention and animal welfare in aquaculture (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 5077442.5
EU funding (EUR): 5077442.5
Participants: 17
Project status: SIGNED

Animal health and welfare are issues of high research priority for European aquaculture. In particular, improving animal welfare whilst reducing the use of veterinary drugs are current research priorities in line with minimizing the environmental impact of the industry. Preventing, or reducing the impact of disease is of prime importance for producers, researchers and stakeholders. In addition, public awareness of aquatic animal health and welfare leads to the increased attention of policy-makers, scientific community and the consumers into new methods for disease prevention. The IGNITION project aims to unveil new knowledge regarding animal welfare in the context of climate change and propose new tools to mitigate the adverse effects of stress. An improvement in animal welfare will translate in higher-quality farmed animals thus improving farming productivity and sustainability performance. Through IGNITION it is expected to provide new knowledge through genotyping and molecular phenotyping techniques to develop future breeding strategies for fish and shellfish. New innovative tools regarding immunization in fish will also be provided, aiming at improving fish welfare and targeting early life stages. Animal feeds will be formulated to include bioactive compounds extracted from halophytes through a novel upstream cascade salt removal. Special emphasis will be given to the study and discovery of new non-invasive biomarkers of health and welfare, which will in turn allow the development of biosensors and disease prediction through machine learning approaches. The tools developed in IGNITION will be able to avoid the colonization and spread of pathogenic microorganisms, including multi-resistant microorganisms, among farmed animals and the subsequent spread to humans through the food chain.

Keywords: biosensors biomarkers machine learning
Increasing transmission distance of wireless power links for active implantable medical devices (LongLinks-4-AIMDs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: TERMINATED

Cardiovascular diseases, neuronal conditions, and metabolic disorders together cause 22 million deaths each year worldwide. Fortunately, those conditions can often be addressed through local sensing and treatments using for example active implantable medical systems (AIMDs) or transcutaneous bioelectronic devices. To be “invisible” to the patients, those devices should have the smallest volume possible, which means they pack only limited data and energy storage, relying on a wireless link to get recharged and to transfer data. Improvement in this link is urgently needed, as today’s poor transfer distance (few centimeters) leads to discomfort, cognitive overload, induces stress, reduces quality of life, and is associated with several suboptimal treatment outcomes. Because of this drawback, many medical solutions already validated in the lab cannot be implemented on patients. My aim is to achieve a major advance in the way energy and data are transferred, and to gain an order of magnitude in the wireless transfer distance over existing technologies, through the development of a novel time-modulated magnetic coupling strategy. The approach will consist of: (WP1) developing a “smart Q-modulation”, which operates in a manner similar to regenerative braking systems, where energy is temporary saved when the quality factor of the resonator has to be reduced for data transmission, and later reused to increase the quality factor for power transmission; (WP2) maintaining the system in energy-efficient operation against the body changing environment, and (WP3) guaranteeing a safe operation of the power transfer link. By enabling new wireless scenarios, this project will enable a whole set of new medical devices to reach the market, providing autonomously and imperceptibly operation to the user, thus alleviating their cognitive burden. The technology will also be transferable to many other applications, such as industrial sensing, reinforcing the European leadership on the field