Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A continental-scale test of the climate hypothesis for the evolution of altruism in insects (WaspCLIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 271732.8
EU funding (EUR): 271732.8
Participants: 2
Project status: SIGNED

This multidisciplinary fellowship will address a key emerging enigma in evolutionary biology: does variation in climate shape the evolution of animal ‘altruism’ (costly cooperation in the service of others)? Recent speculation has suggested that climate influences the power of kin selection (a central mechanism in the evolution of altruism). I will test this hypothesis in four work packages. First, I will provide an analysis of variation in the power of kin selection on an unprecedented latitudinal scale. The African wasp Belonogaster juncea ranges from the equatorial tropics to temperate South Africa, permitting an intraspecific test of the link between climate and altruism. Second, I will conduct extensive behavioural experiments over this latitudinal range to dissect variation in the motivations for cooperation. Third, I will undertake a global comparative analysis of the effects of climate on cooperation in simple eusocial wasps and bees, synthesising decades of published data to parameterise a mathematical model of the evolution of cooperation under different climate regimes. Fourth, I will develop a novel citizen science approach in Sub-Saharan Africa to collect fundamental data on variation in cooperation in wasps, engaging local populations in the practice of ecology at large scales. By providing a multidisciplinary synthesis to test the link between climate and kin selection, WaspCLIM will significantly advance our understanding of the ultimate drivers of altruism – one of the top 25 outstanding scientific questions identified by the journal Science.

Keywords: altruism,evolution of cooperation,social evolution,kin selection,inclusive fitness,wasps,eusociality,climate,hamilton s rule,latitudinal gradients,social insects,hymenoptera
Next-GENeration IoT sOlutions for the Universal Supply chain (iNGENIOUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Spain,Ireland,Italy,Italy,Spain,Germany,Spain,Spain,Italy,Poland,Finland,Finland,France,Luxembourg
Call: Next Generation Internet of Things (H2020-ICT-2020-1, 2020)
Start date: 2020-10-01
End date: 2023-03-31
Duration (months): 30.0
Total project cost (EUR): 7997137.5
EU funding (EUR): 7997137.5
Participants: 22
Project status: SIGNED

During the last decades, supply chains have become huge networks of heterogeneous organisations involved in the manufacturing and delivery of products to end users. The appearance of IoT is transforming every sector subject to be digitalized. After a period of evaluation of the use of IoT, companies are now moving to complete digitalization of their supply chains. Under this paradigm, iNGENIOUS (Next-GENeration IoT sOlutions for the Universal Supply chain) will exploit some of the most innovative and emerging technologies in line with the standardised trend, contributing to the Next-Generation IoT (NG-IoT) and proposing technical and business enablers to build a complete platform for supply chain management. iNGENIOUS embraces the 5G Infrastructure Association (5G IA) and Alliance for Internet of Things Innovation (AIOTI) vision for empowering smart manufacturing and smart mobility verticals. The iNGENIOUS network layer brings new smart 5G-based IoT functi¬onalities, federated Multi-Access Edge Computing (MEC) nodes and smart orchestration, needed for enabling the projected real-time capable use cases of the supply chain. Security and data management are fully recognized as important features in the project. iNGENIOUS will create a holistic security architecture for next-generation IoT built on neuromorphic sensors with security governed by Artificial Intelligence (AI) algorithms and tile-based hardware architectures based on security by design and isolation by default. In the application layer, iNGENIOUS new AI mechanisms will allow more precise predictions than conventional systems. Project outcomes will be validated into 4 large-scale Proof of Concept demonstration, covering 1 factory, 2 ports, and 1 ship, encompassing 6 uses cases. iNGENIOUS is formed by 21 partners from eight countries, including three telecom vendors and manufacturers, two network operators, four logistics partners, two universities, three research institutes and seven high-tech SMEs.

Keywords: supply chain,next generation iot,new radio,smart networks,edge computing,tactile iot,neuromorphic sensors,mixed reality,haptic gloves,blockchain,distributed ledger technologies
Isoreticular Metal Phosphonates for Energy and Light (IMPEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-08
End date: 2022-10-07
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The amount of solar energy received onto the earth in single hour is estimated to be more than the entire annual world energy usage, but at present the implementation and efficiency commercially available of solar cells does not make adequate use of this renewable energy source. It is estimated that 10% of energy usage in the average home, and 20-40% in commercial premises. Furthermore it is predicted that the world will need 30 terawatts (TW) of energy by 2050 which must come from renewables. The EU Renewable Energy Directive in conjunction with the Energy Performance in Buildings Directive has set targets to increase energy efficiency in excess of 32.5% by 2030. In answer to these challenges there is a need to develop new materials for solar energy conversion (photovoltaics) and low energy lighting. The three key challenges in developing new photovoltaics for the conversion of solar energy to electricity are: high efficiency, low cost and long life. In this context, this project aims to develop and study of new multifunctional materials to act as hosts for semiconductor quantum dots and nanoparticles, and to use them in the manufacture and study of solar cells and LEDs. It combines the experience of the PI, Prof Gary Hix, in photonic materials and that of the fellow, Dr Konstantinos Papathanasiou in synthesis of porous materials, to deliver materials which will contribute to global and European Clean Energy objectives. The project will provide a vehicle for a two-way knowledge exchange between the host and fellow, providing the basis for a successful multidisciplinary project spanning chemistry and physics which will also generate data and outcomes that will be of interest to materials scientists and physicists and the wider scientific community in general. The training regime provided for the fellow enable him to establish himself as an independent researcher in his home country, Greece, and in the wider international scientific community.

Keywords: mofs,metal phosphonates,halides perovskites,photovoltaics,leds
Targeting perivascular myofibroblast progenitors to treat cardiac fibrosis and heart failure in chronic kidney disease (CureCKDHeart)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1497888.0
EU funding (EUR): 1497888.0
Participants: 1
Project status: CLOSED

Chronic kidney disease (CKD) is a growing public health problem with a massively increased cardiovascular mortality. Patients with advanced CKD mostly die from sudden cardiac death and recurrent heart failure due to premature cardiac aging with hypertrophy, fibrosis, and capillary rarefaction. I have recently identified the long sought key cardiac myofibroblast progenitor population, an emerging breakthrough that carries the potential to develop novel targeted therapeutics. Genetic ablation of these Gli1+ perivascular progenitors ameliorates fibrosis, cardiac hypertrophy and rescues left-ventricular function. I propose that Gli1+ cells are critically involved in all major pathophysiologic changes in cardiac aging and uremic cardiomyopathy including fibrosis, hypertrophy and capillary rarefaction. I will perform state of the art genetic fate tracing, ablation and in vivo CRISPR/Cas9 genome editing experiments to untangle their complex mechanism of activation and communication with endothelial cells and cardiomyocytes promoting fibrosis, capillary rarefaction, cardiac hypertrophy and heart failure. To identify novel druggable targets I will utilize new mouse models that allow comparative transcript and proteasome profiling assays of these critical myofibroblast precusors in homeostasis, aging and premature aging in CKD. Novel assays with immortalized cardiac Gli1+ cells will allow high throughput screens to identify uremia associated factors of cell activation and inhibitory compounds to facilitate the development of novel therapeutics. This ambitious interdisciplinary project requires the expertise of chemists, physiologists, biomedical researchers and physician scientists to develop novel targeted therapies in cardiac remodeling during aging and CKD. The passion that drives this project results from a simple emerging hypothesis: It is possible to treat heart failure and sudden cardiac death in aging and CKD by targeting perivascular myofibroblast progenitors.

Keywords: chronic kidney disease
Green Integrated Structural Elements for Retrofitting and New Construction of Buildings (GREEN INSTRUCT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Spain,Spain,Austria,Italy,Italy,Cyprus,Greece,Greece,Poland,Portugal,United Kingdom,Portugal,United Kingdom
Call: New technologies and strategies for the development of pre-fabricated elements through the reuse and recycling of construction materials and structures (H2020-EEB-2016, 2016)
Start date: 2016-10-01
End date: 2020-09-30
Duration (months): 48.0
Total project cost (EUR): 4996626.25
EU funding (EUR): 4996626.25
Participants: 17
Project status: CLOSED

The Green INSTRUCT project will develop a prefabricated modular structural building block that is superior to conventional precast reinforced concrete panels by virtue of its reduced weight, improved acoustic and thermal performance and multiple functionalities. The Green INSTRUCT block consists of over 70% of CDW in weight. The Green INSTRUCT project will: (i) achieve sustainability and cost savings through CDW sourced materials and C2C, (ii) develop efficient, robust, eco-friendly and replicable processes, (iii) to enable novel cost efficient products and new supply chains, (iv) develop a building block that renders refurbished or new buildings safe and energy efficient and (v) safeguard a comfortable, healthy and productive environment. They can be achieved by defining the structural, thermal and acoustic performance of our final product to be competitive to similar products in the market. The types and sources of CDW are carefully identified, selected and processed while the supply chain from the sources, processing, fabrication units to assembly site of the whole modular panel will be optimized. The project is guided by a holistic view through building information modelling and optimal overall performance. This includes considering the life cycle analysis, weight, structural performance, thermal and acoustic insulation, connectivity among modular panels and other structural/non-structural components as well as the compatibility of different internal parts of the each modular panel. In order to homogenize the production process, all individual elements are fabricated by extrusion which is a proven cost effective, reliable, scalable and high yield manufacturing technique. The concept, viability and performance of developed modular panels will be verified and demonstrated in two field trials in test cells.

Keywords: construction and demolition waste,energy efficient buildings,extrusion,geopolymer,green wall,magnesium oxychloride cement,phase change material,polyurethane,prefabricate,rheology
A Quantitative Approach to Neolithic Plant-working Techniques: From Assessing Tool Use to Modelling Human Dispersals (QUANT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The QUANT project is designed to study the spread of the Neolithic in the Central and Western Mediterranean through an innovative and multidisciplinary approach to the flaked stone tools. Particular attention will be given to the study of the tools used for plant harvesting and processing tasks (i.e. sickle blades, blade scrapers, burins), which are the most evident innovations in flaked stone technology associated with the Neolithisation phenomenon. The aim is to highlight different traditions in plant-working techniques, and to determine how these were disseminated across the Mediterranean during the Neolithic expansion, between the seventh and the sixth millennium cal BC. The application of new technologies will be fundamental to the success of the project. Use-wear analysis of the stone tools will be integrated with confocal scanning microscopy in order to better analyse the plant-polish variability, which will contribute to the development of functional studies. Obtained results on the regional diversity of plant-working techniques will be modelled through computational approaches. By incorporating GIS-based cost-surface analysis it will be indeed possible to model the dispersal of the plant-working techniques observed, and thus explore the pathways and rhythms of expansion followed by Neolithic groups during their migrations across Mediterranean Europe. New technologies will also play a fundamental role in the presentation and diffusion of the data. An open access library containing photos, micrographs, and quantitative data on the analysed artefacts will be made fully available online. In addition, results will be made available to the general public through the creation of a blog and a website, and through several outreach activities. The project will be very profitable for both the proposer and the Host, and it will contribute notably to European excellence and competitiveness, enhancing public awareness of European history and past migrations.

Keywords: use wear analysis,confocal microscopy,neolithic dispersal,spread of farming,plant economy,prehistoric technology,diffusion of innovation,subsistence and craft technologies
an innovative system for building hulls for recreational and work boats (S.D.S.)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project S.D.S. Strength Distribution System, consists of the creation of an innovative system for building hulls for recreational and work boats. Currently boat hulls are made of considerable, almost uniform thickness throughout, while the forces acting on them are very different in their intensity, direction and the areas on which they are exerted. To simplify construction, the point that undergoes the greatest force is studied and everything is built based on those data. This leads to a considerable increase in weight where this is not necessary. The Strength Distribution System, on the other hand, is characterised by the construction of a thin exoskeleton in red cedar that follows the force lines acting on the hull, thus creating a kind of framework on which planking much thinner than traditional planking is applied. Everything is enclosed within two “skins” of vacuum impregnated carbon or fibreglass. The carbon skins so applied and thus distant from each other act with the strength of a beam, much greater than that of one plane. For the same strength and rigidity, the tests done take us to weights 23-28% lower than a traditional hull. The saving in weight is fundamental because it increases the autonomy of the boat and its safety, reducing consumption and as a result its environmental impact. Because of vacuum impregnation, production costs are slightly higher than for a traditional hull. The boat market tries to reduce weights as much as possible, spending considerable amounts; the Strength Distribution System will be revolutionary because it does not act on materials but on the form. It faithfully reflects the innovative spirit of "Horizon 2020 Work Programme Smart, Green and Integrated Transport” at point 4 “Waterborne". The objective in phase 1 is to create a precise and detailed business plan which defines the technical, economic and commercial feasibility of the solution proposed in order to begin phase 2 starting from solid conceptual bases.

Keywords: hulls,boat,innovative vessel
Evolution of cell fate specification modes in spiral cleavage (EVOCELFATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-07-31
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Spiral cleavage is a highly stereotypical early embryonic program, and the ancestral, defining feature to Spiralia, a major phylogenetic clade including almost half of the animal phyla. Remarkably, spiral-cleaving embryos specify homologous cell fates (e.g. the progenitor cell of posterodorsal structures) conditionally –via cell interactions– or autonomously –via segregation of maternal inputs. This variation occurs naturally, even between closely related species, and has been related to the precocious formation of adult characters (adultation) in larvae of autonomous spiral-cleaving species. How spiralian lineages repeatedly shifted between these two cell fate specification modes is largely unexplored, because the mechanisms controlling spiral cleavage are still poorly characterized. This project tests the hypothesis that maternal chromatin and transcriptional regulators differentially incorporated in oocytes with autonomous spiral cleavage explain the evolution of this mode of cell fate specification. Through a comparative and phylogenetic-guided approach, we will combine bioinformatics, live imaging, and molecular and experimental techniques to: (i) Comprehensively identify differentially supplied maternal factors among spiral cleaving oocytes with distinct cell fate specification modes using comparative RNA-seq and proteomics; (ii) Uncover the developmental mechanisms driving conditional spiral cleavage, which is the ancestral embryonic mode; and (iii) Investigate how maternal chromatin and transcriptional regulators define early cell fates, and whether these factors account for the repeated evolution of autonomous specification modes. Our results will fill a large gap of knowledge in our understanding of spiral cleavage and its evolution. In a broader context, this project will deliver fundamental insights into two core questions in evolutionary developmental biology: how early embryonic programs evolve, and how they contribute to phenotypic change.

Keywords: spiralia,spiral cleavage,evolution,cell fate,annelids,development,epigenomics,evolutionary developmental biology,evodevo