Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Social network tools and procedures for developing entrepreneurial skills in PhD programmes (prodPhD)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Spain,Spain,France,Netherlands
Call: Research innovation needs & skills training in PhD programmes (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-02-28
Duration (months): 26.0
Total project cost (EUR): 298781.25
EU funding (EUR): 298781.25
Participants: 5
Project status: CLOSED

The main objective of the prodPhD project is to implement innovative social network-based methodologies for teaching and learning entrepreneurship in PhD programmes. The multidisciplinary teaching and learning methodologies to be developed will allow introducing entrepreneurship education in any PhD programme of a higher education institution, providing students with the knowledge, skills and motivation to engage in entrepreneurial activities. The methodology will be conceived to develop experiential knowledge, involving academics, entrepreneurship experts and mentors in its development and implementation. Besides, the exchange of experience, competences and approaches facilitated by social networking will allow crowdsourcing new ideas, improving training methodologies and stimulating entrepreneurial skills of academics. In particular, prodPhD will deliver and demonstrate, through different pilot actions, a social network-based training methodology, which will include the necessary teaching guidelines and specific “learning by doing” materials for entrepreneurship training, as well as the required prodPhD Online Training Environment, integrating customized collaborative work and social network solutions. The outcome of the prodPhD project will be openly offered to the higher education community. The project is built on the collaboration with four running ERASMUS+ and MSCA-ITN projects, involving 20 higher education institutions from nine different EU countries, and more than twenty-five companies and research centres. Besides, four running H2020 running projects and sixteen other European associations and organizations will also collaborate with the project by becoming members of the Expert Advisory Board of prodPhD. This collaboration will be fundamental for the specific requirements analysis and for the development and assessment of the demonstration actions to which all the collaborating institutions will be invited to participate.

Keywords: entrepreneurship training,skills training in phd programmes,research employment in academia and,beyond academia
Slovak Centre of Excellence in Ion Beam and Plasma Technologies for Materials Engineering and Nanotechnology (SlovakION)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Germany,Slovakia,Slovakia
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 498906.25
EU funding (EUR): 498906.25
Participants: 7
Project status: CLOSED

The Center of Excellence SlovakION aims to become Eastern Europe’s leading research centre for ion beam and plasma technologies in materials engineering and nanotechnology. Based on cutting-edge research and closely integrated in an international network of research facilities, SlovakION’s holistic approach to innovation transfer and its close interaction with the regional industry will contribute to the economic development of Slovakia. The main focus lies with the automotive and electronics industry as pointed out in Slovakia’s Research and Innovation Strategy for Smart Specialisation. The TEAMING project shall help to develop the new Centre of Excellence as an internationally acclaimed source of excellent research. In close cooperation with the Slovak government and relevant industrial partners, SlovakION will establish and develop an integrated system for technology transfer and applied research. As a long term vision, this Slovak transfer model should be extended on other areas of research and industrial fields. The SlovakION project draws its strength from three major sources: (i) STU is Slovakia’s leading technical university with a long tradition of excellent research and education, (ii) As of today, already €42M has been committed for creating a state-of-the-art facility for ion and plasma technologies. These funds were provided by the European Structural Investment Fund (ESIF), the Slovak Republic Government and the STU, and (iii) HZDR Dresden will be the leading support for SlovakION building on more than a decade of close collaboration. HZDR will not only bring its own experiences in breeding excellent research and develop fruitful technology transfer, but could draw on the whole Dresden research cluster including a leading technical university, several thematically linked Fraun¬hofer sites as well as several public-private partnerships fostering technology transfer.

Keywords: excellence,centre,materials
Fostering Innovation and Creativity in Europe through Public Administration Modernization towards Supplying and Exploiting Linked Open Statistical Data (OpenGovIntelligence)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Estonia,Ireland,Lithuania,Belgium,Greece,Belgium,Greece,Netherlands,United Kingdom,United Kingdom
Call: Meeting new societal needs by using emerging technologies in the public sector (H2020-EURO-6-2015, 2015)
Start date: 2016-02-01
End date: 2019-01-31
Duration (months): 36.0
Total project cost (EUR): 2788012.5
EU funding (EUR): 2788012.5
Participants: 12
Project status: CLOSED

The OpenGovIntelligence project aims at stimulating sustainable economic growth in Europe through fostering innovation in society and enterprises. Towards this end, OpenGovIntelligence suggests a holistic approach for the modernization of Public Administration (PA) by exploiting Linked Open Statistical Data (LOSD) technologies. This includes new business processes, policies, and tools that will enable the active participation of the society and enterprises in data sharing and in the co-production of innovative data-driven public services. The objectives of the OpenGovIntelligence project include: • The identification of challenges in opening up and exploiting LOSD for the co-production of innovative data-driven public services. • The creation of a framework comprising business processes, policies, and data infrastructure architectures. This framework specifies a user-centric LOSD Innovation Ecosystem that orchestrates the collaboration of society and PA for opening up and exploiting LOSD to address relevant challenges and facilitate the co-production of innovative data-driven public services. • The delivery of the OpenGovIntelligece ICT toolkit comprising easy-to-use and user-centric tools to facilitate realizing the LOSD Innovation Ecosystem. • The OpenGovIntelligence pilots in six countries to validate and prove the usability and effectiveness of the LOSD Innovation Ecosystem. The pilots will develop services at both national and local level to tackle societal and PA challenges in various problem areas such as internal decision-making in PAs, enhancing e-services provided by Points of Single Contact in Europe, and improving policy-making in the areas of environment protection, economic growth, and unemployment.

Keywords: public services,co production,open data,linked data
The international dimensions of authoritarian regime survival: comparing “dictaplomatic” strategies in post-Soviet Eurasia (DICTAPLOMACY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Poland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-15
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 146462.4
EU funding (EUR): 146462.4
Participants: 1
Project status: CLOSED

DICTAPLOMACY investigates an understudied dimension of authoritarianism – the use autocrats make of diplomacy as a tool of regime-survival. The project analyses and compares the foreign policy strategies and “dictaplomatic” tactics of four ideal-typical authoritarian regimes in post-Soviet Eurasia, with the aim of modelling the mechanisms whereby diplomacy serves them for external regime-legitimation and authoritarian consolidation. DICTAPLOMACY is a multidisciplinary project that combines insights and methods from comparative politics, international relations (IR) theories and foreign policy-making analysis. It elaborates an innovative framework for analysing rogue behaviour in contemporary IR. It departs from the idea that the EU’s democracy-promotion efforts in Eastern Europe require a better understanding of the foreign policy manoeuvres of post-Soviet authoritarian regimes. In identifying the international components of authoritarian resilience, DICTAPLOMACY also highlights which incentives and coercive means could limit the resilience and contain the diffusion of authoritarian governance. This is a timely endeavour, given the growing assertiveness of Russia in world affairs, and the emerging “nuisance” capacity of many of its undemocratic neighbours (Belarus, Azerbaijan and Kazakhstan notably) in regional affairs. Building on the researcher’s expertise in post-Soviet transition and the geopolitics of Eurasia, as well as on the leading academic experience of the host institution in diplomatic studies, the Individual Fellowship will provide the experienced researcher with a chance to acquire new skills, thus reinforcing her maturity as an IR scholar, as well as the host institution’s own visibility in the European Research Area. DICTAPLOMACY is a policy-relevant project with a strong potential to entail cross-disciplinary fertilisation between scientific research and policy-advocacy work as well, thanks to the researcher’s planned secondment in a think tank.

Keywords: comparative politics authoritarian regime,dictatorship,international relations theory diplomacy,foreign policy decision making,post soviet eurasia russia,belarus,azerbaijan,kazakhstan
The smallest of the small: determining size through cell number (GrowCELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-08-01
End date: 2025-01-31
Duration (months): 78.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Determination of organismal size is a fundamental biological question. Vertebrate size is established based on total cell number generated during development. Despite the 75 million-fold difference in size between the smallest and largest mammals, the mechanisms for this remain to be determined. This proposal seeks insight into how total cell number is determined in both pathological and physiological states. Over the last decade our study of extreme growth disorders has identified 18 new human disease genes. We established these encode core components of the cell-cycle machinery, providing cellular and developmental insights into the pathophysiological mechanisms of these disorders. From our starting point of human disease, this approach also revealed novel genome instability genes informing fundamental research of basic biological processes. Still, the molecular basis for over half of individuals with microcephalic dwarfism remains unknown. This proposal will break new ground through the comprehensive application of Whole Genome Sequencing to our patient cohort to achieve screen saturation via identification of coding and non-coding mutations. Forward-genetic genome-wide CRISPR screens in developmentally relevant cell and organoid systems will also be developed to define key cellular processes impacting human growth. Beyond these ‘discovery science’ approaches, cellular and model organism techniques will be used to define the mechanistic basis for human disease caused by mutations in core replication machinery and key epigenetic factors. To extend prior work on pathophysiological mechanisms, we aim to establish a subset of microcephalic dwarfism genes as growth regulators, and thereby further define when and how organism size is determined. These studies will link essential cellular machinery governing proliferation with human disease, identify novel genome-stability factors and may yield insights into the developmental regulation of mammalian size.

Keywords: organism size determination,human genetics,mendelian disease gene identification,dna replication,genome stability,stem cells,dna methyltransferases
Flexible Euv SpecTrometer for Attosecond science (FESTA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-10-01
End date: 2020-12-31
Duration (months): 27.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Attosecond science studies the motion of electrons on atomic and molecular scale, which typically occurs on the timescale of attoseconds (1 as = 10^-18 s). This motion is at the basis of all fundamental processes occurring in Chemistry, Material Science and Biology, and its understanding enables innovation in all these scientific fields. The access to electronic motion on the timescale of attoseconds is based on the analysis of extreme ultra-violet (EUV) harmonic radiation generated when a molecule is hit by an intense femtosecond (1 fs = 10^-15 s) laser pulse. However, despite its huge potential, the full exploitation of this approach is currently hindered by limitations in the commercially available EUV spectrometers and it is restricted to a few very specialized users who are able to build their own instruments. By exploiting the innovative technical methods developed during UDynI ERC, we want to realize a compact, versatile, and user-friendly EUV spectrometer, which overcomes these limitations. In this way, we will grant access to attosecond science to a wider range of stakeholders in fields with high impact on the society, such as Health (e.g. drug discovery), Environment (e.g. understanding atmospheric photoinduced pollution, finding more effective chemical and catalytic processes) and Technology (e.g. study of high temperature superconductors and ultrafast switching in magnetic materials). The objective of the FESTA PoC Project is the development of a EUV detection system prototype (TRL6), the identification of a proper IPR exploitation strategy and the definition of the most suitable business model for the commercialization of the FESTA platform.

Keywords: high order harmonic generation,attosecond spectroscopy
Hypoxic regulation of senescent cells secretome in lung cancer and Alzheimer's disease (SENOXIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-10
End date: 2024-01-09
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Research over the last decade has convincingly evidenced that cellular senescence and low oxygen (O2) availability (hypoxia) are distinctive features involved in the physiopathology of age-related disorders including lung cancer and Alzheimer’s disease (AD). Cellular senescence is characterised by a permanent and irreversible cell cycle arrest and the acquisition of an intense senescence associated secretory phenotype (SASP). Mounting evidence has shown that the SASP accounts for most of the detrimental effects of senescent cells accumulated in aged tissues. Therefore, understanding the mechanisms that modulate the composition and intensity of the SASP is a fundamental biological question with significant translational implications in age-related disorders. Senescent cells accumulate in tissues where O2 is very limited. To live under these conditions, senescent cells must adapt to hypoxia via the stabilisation of hypoxia inducible transcription factor (HIF). I hypothesise that local hypoxia determines the composition and intensity of the SASP in age-related disorders, a concept that I will name hSASP. Given the intrinsic heterogeneity of the SASP across tissues, I will test this hypothesis in lung cancer and AD models where there is a concomitant accumulation of senescent cells in hypoxic areas. I will use a variety of genotoxic agents to induce cellular senescence in lung cancer and stromal cells as well as in murine primary astrocytes exposed to a decreasing range of O2 tensions. I will elucidate the role of hypoxia in regulating the composition and intensity of the hSASP and its paracrine effects on nearby cells. Finally, I will identify relevant hSASP factors and define their functional effects on lung cancer and microglial cells. Targeting specific hSASP factors may offer new therapeutic opportunities to attenuate the adverse effects of senescent cells accumulated in age-related disorders such as lung cancer or AD.

Keywords: hypoxia,senescence,sasp,lung cancer,alzheimer s disease,ageing
An ultra-wideband-based location system that allows highly accurate positioning in indoor environments. (Pozyx RTLS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nowadays more than 80-90% of people’s time is spent indoors. Most of this time is spent at the work place, where, the position of a user or a device in a given space is one of the most important elements of contextual information. Location detection, such as the GPS technology, has made a tremendous impact on our everyday lives. Nevertheless, in indoor environments, the usability of the GPS is limited. Radio Frequency Signals (RF) like Wi-Fi, RFID and Bluetooth, light-based technologies like infrared light, sound technologies, and magnetic fields- are all systems commonly used for indoor positioning. However, with an accuracy ranging from 1 to 5m, these technologies are simply not accurate enough for tomorrow’s Industrial Internet of Things. Pozyx Real Time Locating System (RTLS) is GPS for indoors environments. Thanks to our proprietary algorithm that leverages in Ultra-Wideband technology for unparalleled accurate positioning, it is the first IPS to reach up to 10cm accuracy. We is starting a new era of accurate positioning: Pozyx RTLS is as accurate as the most reliable systems in the market like Camera systems and LIDAR with prices that can easily compete with the most affordable systems like Wi-Fi or Bluetooth. So far €747K have been invested into the development of the Pozyx RTLS to ensure and continuously improve its robustness and efficiency. We still need a further investment of €1.8M which will also allow us to finalise engineering and set up a solid EU value chain able to meet the large demand expected during the first years of commercialisation. This will eventually ease our access to new markets, like the entertainment industry. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of the Pozyx RTLS and its market uptake.

Keywords: indoor positioning,warehousing,logistics,retail,and farming,ultra wideband
The Neuronal Code of Inheritance (RNAflashbacks)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Little is known about non-DNA mediated transgenerational inheritance of parental responses. If inheritance of non-genetic materials is prevalent, it could challenge our conceptions regarding the rules and limits of heredity. We are in particularly intrigued by the possibility that the nervous system can produce heritable changes. Mechanisms for propagation of responses from the soma to the germline are known. Until very recently, the possibility that any type of environmental response could become heritable, let alone somatic responses, was considered blasphemous. In C. elegans nematodes, exogenously-supplied artificial dsRNA transfers from the soma to the germline, triggering transgenerational small RNA-mediated RNA interference. It is unknown whether endogenous small RNAs can transmit specific information about the environment to the progeny. We will investigate if endogenous siRNAs, which are naturally made in somatic tissues, and in particular in neurons, produce transgenerational responses. Specifically, we will test which RNA molecules act transgenerationally, how do they mediate non-cell autonomous gene regulation, and which responses can be communicated to the progeny. What is the code that transforms particular environmental responses to specific arsenals of heritable RNA molecules? We will answer these questions, and moreover study the implications that this completely new form of hereditary has for the offspring’s survival. Can heritable small RNAs retain adaptive memory? Not only will we elucidate natural transmission of the parents’ activity from generation-to-generation, we will moreover devise means to control these mechanisms. We will engineer tools to diagnose, erase, maintain, and modulate the heritable effects, which would be important for basic research and hopefully also translational in the future.

Keywords: transgenerational inheritance,small rnas,non genetic inheritance,non mendelian genetics,c elegans