Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SAC robustness in the transition from meiosis to mitosis (SAC_EarlyEmbryo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Meiotic divisions in the oocyte have been shown to be surprisingly error-prone compared to the reliable chromosome segregation that takes place in dividing somatic cells. The high frequency of chromosomal abnormalities found in pre-implantation embryos in mammals coupled with the fact that the first divisions of the embryo resembles meiosis in several aspects suggests that the mechanisms controlling chromosome segregation, most importantly the spindle assembly checkpoint (SAC), only become fully operational after the transition from meiosis to mitosis during early development. Despite the importance for early embryonic development, the sensitivity of mammalian embryos to light and the absence of a functional reporter of the SAC in mice have precluded real-time imaging of chromosome segregation and its control in the first embryonic divisions. Recent advances in light sheet microscopy in the Ellenberg lab now allow me to study chromosome segregation. In addition, in collaboration with the EMBL Transgenic Facility I will be able to rapidly generate the first SAC reporter mice that will permit me to test the checkpoint functionality up to the blastocyst stage. Taking advantage of this unique opportunity to combine new technology with a novel reporter animal model, I plan to study how the SAC changes from meiosis to the first embryonic divisions of blastocysts. To this end, I will analyze SAC signalling and dynamics and assess whether the robustness of the SAC increases with development. My project aims to improve our understanding of chromosome segregation during mammalian pre-implantation development, and therefore the results of my research will be important to shed light on the molecular causes of aneuploidy in the early embryo, fundamental for our understanding of infertility and to improve the process of in vitro fertilization.

Keywords: spindle assembly checkpoint,oocyte,pre implantation embryo,meiosis,mitosis,laser nanosurgery,chromosome mis segregation
An Adaptive Trust-based e-assesment System for Learning (TeSLA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Belgium,Türkiye,Belgium,Bulgaria,Finland,Switzerland,France,Netherlands,United Kingdom,United Kingdom,Mexico,Portugal
Call: Technologies for better human learning and teaching (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2019-03-31
Duration (months): 39.0
Total project cost (EUR): 7283092.5
EU funding (EUR): 5916028.5
Participants: 18
Project status: CLOSED

Although online education is a paramount pillar of formal, non-formal and informal learning, institutions may still be reluctant to wager for a fully online educational model. As such, there is still a reliance on face-to-face assessment, since online alternatives do not have the deserved expected social recognition and reliability. Thus, the creation of an e-assessment system that will be able to provide effective proof of student identity, authorship within the integration of selected technologies in current learning activities in a scalable and cost efficient manner would be very advantageous. The TeSLA project provides to educational institutions, an adaptive trust e-assessment system for assuring e-assessment processes in online and blended environments. It will support both continuous and final assessment to improve the trust level across students, teachers and institutions. The system will be developed taking into account quality assurance agencies in education, privacy and ethical issues and educational and technological requirements throughout Europe. It will follow the interoperability standards for integration into different learning environment systems providing a scalable and adaptive solution. The TeSLA system will be developed to reduce the current restrictions of time and physical space in teaching and learning, which opens up new opportunities for learners with physical or mental disabilities as well as respecting social and cultural differences. Given the innovative action of the project, the current gap in e-assessment and the growing number of institutions interested in offering online education, the project will conduct large scale pilots to evaluate and assure the reliability of the TeSLA system. By the nature of the product, dissemination will be performed across schools, higher education institutions and vocational training centres. A free version will be distributed, although a commercial-premium version will be launched on the market.

Keywords: e assessment system,innovative technology,enhanced educational processes,online and blended learning environments,security,privacy,authentication,authorship,reliability,adaptive,scalable
The History Play and the British Enlightenment, 1750-1815 (HISTPLAY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-08-31
Duration (months): 27.0
Total project cost (EUR): 201514.5
EU funding (EUR): 201514.5
Participants: 2
Project status: CLOSED

The aim of this Fellowship is for the researcher, Dr David O’Shaughnessy, to develop the professional prowess, advanced training, high-impact dissemination, and practical experience commensurate with a leading independent researcher in the EU. The researcher will be based for 15 months at the Huntington Library, California (HL) supervised by Professor Kevin Gilmartin and for 12 months at the School of English, Trinity College Dublin (TCD) supervised by Dr Aileen Douglas. Research training will be implemented through an interdisciplinary project investigating the importance of the history play to the discussion and dissemination of Enlightenment ideas in the two main London theatres of the eighteenth century, Covent Garden and Drury Lane, 1750-1815. The key output will be the first monograph to be written on the eighteenth-century history play but the project will also communicate knowledge to a public audience through appropriate activities. On the outgoing phase of the Fellowship, the researcher will access expertise, advanced training, mentoring as well as having access to the Larpent Collection of theatre manuscripts at the HL, the most important archive in the world for the study of eighteenth-century theatre. Due to its unique archive holdings, the HL is the only institution in the world that can host this project; it also has collaborative relationships with Caltech and the University of Southern California (USC) which will benefit the research in significant ways. In TCD the researcher will be given the opportunity to embed his new knowledge through undergraduate and postgraduate teaching, conferences and a symposium, and continued research. The resources of the host institutions will facilitate development of an interdisciplinary and international academic network as well as career-mentoring. The Fellowship will establish the researcher firmly at the centre of eighteenth-century theatre studies and position him for a successful ERC Consolidator application.

Keywords: eighteenth century theatre history,enlightenment studies,cultural history,history of ideas
Chaos-based information processing using spintronic nano-oscillators (CHAOSPIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 2
Project status: CLOSED

ChaoSpin is a frontier research project at the interface between nanomagnetism, spintronics, and nonlinear dynamics. It is motivated by the premise that the rich behaviour of nonlinear systems, in particular chaos, can be leveraged for alternative computing paradigms. The primary objective is to establish the utility and feasibility of the nanocontact vortex oscillator, a nanoscale spintronic device, as a universal building block for chaos-based information processing by demonstrating key technological functionalities, such as random number generation and communication using symbolic dynamics. The underlying idea is that the complexity required for computation and possible cognitive functions can be generated within a single system, without the need of a complex array of interconnected subsystems. The project builds upon the host institution’s recent discovery of novel commensurate and chaotic phases in the nanocontact vortex oscillator. The technical objectives will be met by addressing three important scientific questions related to magnetic vortex dynamics on the nanoscale, namely the nature of the chaotic state, how it can be controlled through external forcing and feedback, and whether such dynamics can be detected experimentally. This will be achieved by combining the development of high-performance simulation tools and quantitative theories with state-of-the-art experiments involving high- frequency electrical characterisation.

Keywords: spin torque oscillators,vortex dynamics,nanomagnetism,chaos theory,magnetisation dynamics
Renormalisation, dynamics, and hyperbolic symmetry (SPINRG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1250043.0
EU funding (EUR): 1250043.0
Participants: 1
Project status: SUSPENDED

The objective of this proposal is to develop effective methods for the analysis of classical continuous spin systems, with focus on their stochastic dynamics and on spin systems with hyperbolic symmetry. The latter are related to reinforced random walks and to random operators. In particular, I propose to develop mathematical methods for renormalisation group analysis of such systems. Renormalisation is a central concept in theoretical physics, explaining a vast range of phenomena heuristically. While its rigorous implementation is difficult, when a renormalisation group approach to a problem is available, it provides very detailed control and also explains universality. Both, in stochastic dynamics of large scale systems and in random matrix theory, great progress has been achieved recently. In stochastic dynamics, this applies in particular to the problem of existence of solutions to SPDEs and their regularity (ultraviolet problem). This proposal focuses on the complementary regime of long time asymptotics (infrared problem), where important results have been obtained via exact solutions but robust methods remain scarce. In random matrix theory, very general classes of random matrices have been understood, yet those with finite dimensional structure like the Anderson model remain out of reach. Spin systems with hyperbolic symmetry and supersymmetry arise in the descriptions of such random matrices, and their simplified versions are prototypes for the understanding of the original models. They also describe linearly reinforced random walks which are of independent interest, and allow for some of the quantum phenomena to be reinterpreted probabilistically. I will build on methods that I developed in previous work, including renormalisation group analysis for static systems, the development of a renormalisation group approach to Glauber dynamics, the study of spin systems with hyperbolic symmetry and supersymmetry, and my experience in random matrix theory.

Keywords: renormalisation group,spin systems,glauber dynamics,random matrices
Next Generation Modular EGSE Architecture (NG-EGSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Greece
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Through the digitalization & Space 4.0 program, the space industry is transforming many elements of its engineering process. In that frame, one of the main targets is the improvement of the Integration Verification and Validation (IVV) process through cost reduction and duration optimization. Electrical Ground Support Equipment are essential tools at all levels of pre-launching testing of satellite / spacecraft namely the Assembly, Integration and Test and/or Verification activities (AIT/AIV). The current EGSEs challenges are: • Current solutions are hardly reusable & very costly, usually being custom developed for each mission/spacecraft. • New technologies available from the IT sector, which have not yet affected the EGSE market. • There are new standards (EGS-CC) to support space systems test, monitoring and control. There is a clear need coming from Spacecraft Manufacturers for new generation EGSEs, providing the opportunity to challenge the current architectures & suppliers. In this context, TELETEL wants to initiate the next generation modular EGSE architecture (NG-EGSE) project, to achieve the following main benefits: • Establishment of a breakthrough innovative modular EGSE architecture, influencing cost and duration of the AIT/AIV operations in the space sector. • Improve the competitive positioning of TELETEL in space EGSE market with game-changing, low cost EGSEs solutions, different to any alternative in the market. • New opportunities in the general avionics market (not only space related). • New EGSEs Building Blocks ready for use by Spacecraft Manufacturers such as Thales Alenia Space & Airbus Defence & Space.

Keywords: electrical ground support equipment egse,modular egse architecture
Wall-Crossing and Algebraic Geometry (WallCrossAG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 1999840.0
EU funding (EUR): 1999840.0
Participants: 1
Project status: SIGNED

We will establish stability conditions and wall-crossing in derived categories as a standard methodology for a wide range of fundamental problems in algebraic geometry. Previous work based on wall-crossing, in particular my joint work with Macri, has led to breakthroughs on the birational geometry of moduli spaces and related varieties. Recent advances have made clear that the power of stability conditions extends far beyond this setting, allowing us to study vanishing theorems or bounds on global sections, Brill-Noether problems, or moduli spaces of varieties. The Brill-Noether problem is one of the oldest and most fundamental questions of algebraic geometry, aiming to classify possible degrees and embedding dimensions of embeddings of a given variety into projective spaces. Recent work by myself, a post-doc (Chunyi Li) and a PhD student (Feyzbakhsh) of mine has established wall-crossing as a powerful new method for such questions. We will push this method further, all the way towards a proof of Green's conjecture, and the Green-Lazarsfeld conjecture, for all smooth curves. We will use similar methods to prove new Bogomolov-Gieseker type inequalities for Chern classes of stable sheaves and complexes on higher-dimensional varieties. In addition to constructing stability conditions on projective threefolds---the biggest open problem within the theory of stability conditions, we will apply them to study moduli spaces of sheaves on higher-dimensional varieties, and to characterise special abelian varieties. We will use the construction of stability conditions for families of varieties in my current joint work to systematically study the geometry of Fano threefolds and fourfolds, in particular their moduli spaces, by establishing relations between different moduli spaces, and describing their Torelli maps. Finally, we will study rationality questions, with a particular view towards a wall-crossing proof of the irrationality of the very general cubic fourfold.

Keywords: algebraic geometry,derived categories,stability conditions,wall crossing,moduli spaces,brill noether,fano varieties,bogomolov gieseker inequality
Unlikely refuge? Refugees and citizens in East-Central Europe in the 20th century (UnRef)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Czechia
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1995950.0
EU funding (EUR): 1995950.0
Participants: 1
Project status: SIGNED

The project aims to write refugees back into the history of East-Central Europe in the 20th century. In this “age of refugees”, the region became a destination of large refugee migrations, forcing civil societies and governments to negotiate difficult decisions about protection for those fleeing the war and persecution. Yet, at the same time, East-Central Europe does not enjoy the reputation as a welcoming place for people persecuted for political persuasion, for their “racial”, ethnic identity or any other reason. It would appear that the histories of ethnic conflict and violence, political oppression and economic underdevelopment make it a place to leave behind rather than to search for as a safe harbour. Studies about specific groups and instances notwithstanding, historical research remains highly unsatisfactory, failing to address refugee protection in a systematic comparative way and transcending national master narratives. Worse than this, historical writing about refugees in the “East” often re-inscribes the very (ethnic, political) categories which lead to the production of refugees in the first place. Comparative research spanning across a longer period and a wider territory promises therefore not only major insights about the “East” as a refuge, but also a significant contribution to the emerging field of global refugee history. In this project, an international research team led by the PI will, using comparative historical research combined with multi-disciplinary approaches, probe the multifaceted entanglements with refugees in countries created in 1918 on the ruins of the Habsburg Monarchy (Poland, Czechoslovakia, Austria, Hungary, Yugoslavia) over the 20th century. By doing so, it wishes to return the discussion of protection of refugees into the region’s history and to contribute – from a scholarly perspective – to the cultivation of current and future public debate about this divisive subject.

Keywords: refugees,citizenship,east central europe,borders,multiethnic societies
Emergent toxins on the Portuguese coast: occurrence, transfer kinetics and toxicity (ETOXPT)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2021-09-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: SIGNED

The occurrence of toxins typical from tropical environments in European Union (EU) temperate coastal waters has been sporadically reported in the past years, usually preceded by human intoxication episodes. Therefore, in order to avoid public health impacts, there is a need for adequate monitoring programs, establishing appropriate legislation, and for optimizing effective methods for the analysis of these toxins. However, due to the very limited quantitative data and the lack of validated analytical methodology, risk associated with the exposure to emergent toxins in EU is currently not possible to determine. In ETOXPT, we will assess the current situation on the incidence and routes of exposure of emergent toxins (i.e. ciguatoxins, CTXs; tetrodotoxin, TTX; palytoxins, PLTXs; and ß-methylamino-L-alanine, BMAA) in Portuguese coastal waters using reliable LC-MS/MS methods. Additionally, the relationship of emergent toxins concentrations and profiles within trophic levels will be evaluated. These field data will be complemented with a mesocosm experiment, in which the potential of CTXs transfer, biotransformation and biodegradation along the food web will be predicted. We will also evaluate the cytotoxicity of individual PLTXs and CTXs analogues. Concurrently, we will develop innovative approaches to analyze the emergent toxins using nanocontainers. ETOXPT will be useful to advance understanding of emergent toxins kinetics, both within individuals and among trophic levels and could support the development of predictive models of risk assessment and contribute to the integration of emergent toxins in shellfish monitoring programs.

Keywords: tetrodotoxin,palytoxins,ciguatoxins,bmaa,mesocosm,lc ms,nanocontainers