Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A novel approach to improved navigation performance through memory triggering maps (InnerMap)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2498390.0
EU funding (EUR): 2498390.0
Participants: 1
Project status: SIGNED

As people become more mobile, navigation systems in cars or mobile phones are playing an increasingly important role in spatial orientation and navigation. However, the "cognitive map" created in the user's mind when using such navigation devices is much more fragmented, incomplete and inaccurate, compared to the mental model of space created when reading a conventional printed map. As users become more dependent on digital devices that reduce orientation skills, there is an urgent need to develop more efficient navigation systems that promote orientation skills. In order to improve the performance of navigation systems, the proposed project aims to develop the theoretical framework for map-based interfaces that primarily take internal brain capacities into account instead of the usual landmark recognition. To meet this challenge, I suggest a new cartographic concept based on recent neuroscientific findings that link spatially tuned brain cells to navigation processes. Namely, the firing activities of grid cells can be influenced by environmental cues such as walls or boundaries. Based on this mechanism, I hypothesise that grid cell activities in the brain can be stabilised through map elements. Linking map-based navigation with neural mechanisms that play a crucial role in human orientation could thus significantly accelerate the construction of spatial mental representations. This research will develop a new approach to improving navigation performance by conducting a series of empirical studies using functional magnetic resonance imaging (fMRI), electroencephalographic (EEG) measurements, virtual reality (VR) and behavioural studies (eye tracking). If successful, the proposed research could transform our understanding of navigation and map reading processes. The impact on human orientation ability can be enormous, as the project results could be applicable to the whole spectrum of cartographic visualisations e.g. in cars, airplanes or mobile devices.

Keywords: cognitive cartography,navigation,map reading,grid cells,orientation skills,navigation system,
Exploring the Neighbourhood Planning Factors that Influence Residential Wellbeing (WellbeMap)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 1
Project status: SIGNED

The United Nations has a goal to promote good health and wellbeing by 2030 (SDG3). The extent to which people are satisified with their neighbourhoods (their residential wellbeing RW) can account for up to 15% of their overall life satisfaction (mental wellbeing). Previous research applied qualitative and quantitative methods to understand the relationship between neighbourhood planning and wellbeing. However, due to the inconsistency in defining the spatial scale of neighbourhood and the failure to capture neighbourhood complexity in analysis, there has not been yet a comprehensive evidence-based framework of neighbourhood planning factors that influence RW. Therefore, this project (WellbeMap) aims to explore the neighbourhood planning and design factors associated with RW and whether those factors are objective or depend on individual residential needs. WellbeMap will take Dublin 8 (D8), a district in Dublin, Ireland, as a case study. It will (i) collect social data to identify subjective neighbourhood boundaries, neighbourhood needs, RW and urban planning data in D8; and (ii) analyse the relationship between urban planning data, RW and neighbourhood needs. Through the combined expertise of the applicant and the supervisor and the research environment at Maynooth University Social Science Institute (MUSSI) and the ADAPT centre, we will translate the concept of RW into a framework of factors that urban planners can control. This will contribute to people's mental wellbeing and, in turn, advance progress towards SDG3. WellbeMap will also have an impact on the applicant and the host organisation through the exchange of knowledge between MUSSI, ADAPT and the applicant. MUSSI and ADAPT will advance the applicant's career by building her capacity in quantitative spatial analysis and Machine Learning, project management and research commercialisation while the applicant will transfer her knowledge on urban design analysis, simulation and planning in Egypt.

Keywords: neighbourhood satisfaction residential wellbeing gis sdg3 dublin 8
Integrating longitudinal multi-modal profiling of metastatic breast cancer patients for high-definition oncology (HD-BRECA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Precision Oncology has revolutionized cancer therapeutics, mostly by matching genomic alterations with molecularly targeted agents. Yet, current predictive capacity is imperfect even in best-case scenarios (tumors driven by oncogene addiction against which a targeted agent exists). To push the field forward, we propose to exploit recent technological advances to analyze longitudinal profiles of cancer patients that encompass dimensions beyond the genetic profile: physiological monitoring, e-health records, patient-reported outcomes, medical imaging, and multi-omics. The integration of this multi-dimensional data with personalized genomics will allow an unprecedented level of understanding of cancer processes, identifying the features that drive patient disease trajectories, eliciting truly precision interventions. The goal of this project is to use this approach to improve the current predictive ability and break current efficacy plateaus in advanced breast cancers. I will integrate longitudinal data of a cohort of 100 hormone receptor-positive metastatic breast cancer patients in first line of treatment with CDK4/6 inhibitors and hormone inhibitors, monitored until disease progression or treatment failure. This constitutes the largest high-definition medicine study in advanced breast cancer patients to date. I will use data across 10 different modalities to establish disease trajectories, relate molecular features to clinical outcomes and build predictive models for prognosis. This integrative project combines translational and clinical oncology, engineering, and data science, to transition from the current genomics-centered precision oncology approach to high-definition oncology, a model in which deep longitudinal patient monitoring achieves a comprehensive personalized oncology.

Keywords: breast cancer,longitudinal multi omics
Monitoring and elimination of bycatch of endangered and conserved species in the NE and high seas Atlantic region (Marine Beacon)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Ireland,Spain,Iceland,Denmark,France,Belgium,Portugal,Greenland,United Kingdom
Call: Understanding and reducing bycatch of protected species (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-01-01
End date: 2028-06-30
Duration (months): 54.0
Total project cost (EUR): 8815276.25
EU funding (EUR): 8815251.25
Participants: 21
Project status: SIGNED

Bycatch, the unintentional capture of non-target marine animals during fishing, is considered one of the greatest threats to marine species globally. This threat is particularly significant for protected, endangered and threatened species (PETS), including marine mammals, seabirds, turtles and sensitive fish species, with their bycatch threatening marine ecosystem health. While bycatch of PETS is recognized as a significant issue, advances in fully understanding risks to PETS have been limited, due to current inability to effectively monitor wide ranging, highly mobile and cryptic species. There has been further lack in advancement in approaches to reduce such risks. These issues all hinder Member States ability to eliminate and significantly reduce bycatch. MarineBeacon will respond to these challenges, working across a regional seas scale to identifying where significant gaps in understanding lie, and adopt innovative approaches to produce the knowledge and tools to better understand bycatch risk and vulnerability. Next generation monitoring tools will be produced and developed to improve understanding of the distribution and abundance of PETS in addition to the levels in which they interact with fisheries. Cutting-edge mitigation tools and techniques will then be extensively tested across diverse fisheries and regions to ensure transferable outputs are generated to significantly mitigate against bycatch risk. MarineBeacon will facilitate the uptake and adoption of its targeted outputs by policy, management, and industry by adopting a stakeholder centered approach, engaging and collaborating with stakeholder throughout the project to producing best acceptable solutions. Importantly, MarineBeacon will ensure long-term applicability and impact of outputs beyond the lifetime of the project through the production of a suite of decision support tools to ensure all measures to better monitor PETS and mitigate against bycatch risk are effectively targeted.

Keywords: knowledge,species distribution,monitoring,mitigation,co creation,stakeholder participation
Novel targeted intervention to prevent brain aneurysm rupture (INTERRUPT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In the European Union, an estimated 15 million individuals harbour unruptured intracranial aneurysms (IAs), each at constant risk of rupture and subsequent subarachnoid haemorrhage (SAH). The imminent threat of IA rupture remains a significant clinical challenge, further exacerbated by the absence of safe and efficacious non-invasive treatments, mainly due to gaps in understanding the underlying mechanisms. Notably, intrasaccular clot formation is a prevalent feature of both ruptured and unruptured IAs, with activated platelets facilitating leukocyte recruitment. We hypothesize that platelets play a pivotal role in the development and rupture of IAs. We have identified a platelet receptor as a critical factor in IA rupture, based on compelling data from a preclinical mouse model. The goal of our ERC-POC project is to investigate and establish pharmacological inhibition of this platelet receptor as a groundbreaking therapeutic strategy for preventing IA rupture. To achieve this, we have designed a comprehensive, interdisciplinary approach encompassing a preclinical model and computational fluid dynamics applied to 3D aneurysm-like vessels. Our objectives are to validate the efficacy of inhibiting this platelet receptor in preventing IA rupture in mice and to thoroughly examine the impact of a receptor inhibitor on platelet function under dynamic conditions that mimic aneurysmal environments. Ultimately, our project aims to establish the clinical proof of targeting this platelet receptor with a leading compound to prevent IA rupture and significantly reduce the risk of SAH. By doing so, we aspire to alleviate the societal burden of intracranial aneurysms, offering a pioneering therapeutic framework for the management of unruptured IA.
Interdisciplinary Centre for Artificial Intelligence in Medicine (AI4MED)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Poland
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2499625.0
EU funding (EUR): 2499625.0
Participants: 1
Project status: CLOSED

The main aim of this project is to establish a new research center at the Jagiellonian University (JU) in Kraków (Poland). The center will conduct high quality interdisciplinary research connecting artificial intelligence (AI) with healthcare. This group will build on the groundbreaking AI research that is currently conducted at JU. They will apply this work to medical applications, and translate the results into clinical practice. The center will be primarily devoted to research excellence and innovation, but will also operate as a thought leader and an entrepreneurial hub in the medical AI space. The group will be led by an outstanding, internationally recognized physician-scientist with significant achievements in deep learning and medical image analysis. Under his leadership, Polish AI research groups, from JU and beyond, will be able to connect their foundational work with medical experts, which will bring clinicians closer to scientific developments. The ERA Chair holder will be supported by JU faculty and an Advisory Board composed of internationally renowned scientists from top universities across the world, including Harvard University, New York University, Karolinska Institute, and the University of Girona. The center will become an attractive entity and a leader in the medical AI field through research excellence, the improvement of interdisciplinary and international mobility and collaboration, and the creation of attractive courses at the JU. Activities that will lead to this goal are described in 6 Work Packages. In the long-term, work undertaken by the center’s members will have wide societal impacts, primarily through the development of next-negation clinical tools, which will lead to better patient outcomes.

Keywords: artificial intelligence,deep learning,medical data,weak labels,missing data,explainability
Demonstration of innovative functional food production systems based on a sustainable value chain of marine and freshwater raw materials for conscientious European consumers (NOVAFOODIES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Spain,Italy,Germany,Estonia,Greece,Romania,Ireland,Portugal,Austria,Hungary,Cyprus,Israel,China,Türkiye,France,Czechia,Slovenia
Call: Innovative food from marine and freshwater ecosystems (HORIZON-CL6-2022-FARM2FORK-02-two-stage, 2022)
Start date: 2023-05-01
End date: 2026-10-31
Duration (months): 42.0
Total project cost (EUR): 6515935.15
EU funding (EUR): 5999988.63
Participants: 38
Project status: SIGNED

NOVAFOODIES will offer novel & competitive functional products to European consumers from a reliable, traceable, and sustainable fisheries and aquaculture value chains. To reach this, NOVAFOODIES is composed of an international consortium covering the whole value chain and expertise: production, processing, transformation, biosecurity, legislation, consumer associations, experts in business, IT, and sustainability. NOVAFOODIES will: -Demonstrate at TRL 6-7, in 10 cases studies, cost-efficient and sustainable fish, micro- and macro- algae production processes that will benefit from natural ecosystem services. -Bring to TRL6 an innovative & sustainable microwave-assisted algae drying process to maximising efficiency and lower costs -Upscaling to TRL 6-7 an innovative biorefinery concept for separation of functional extracts from fish and seaweeds which will be optimised for the technoeconomic and environmental validation. 12 functional food prototypes will be prepared using these extracts as well as fish, bycatch & algae for human products, and aquafeeds, which will be assessed in terms of properties, biosecurity, and standards, and will be brought to consumers by educative activities as e.g. showcookings. -Bring to TRL7 an innovative process to make ecological packaging material from macroalgae -Bring to TRL6 a process to convert the beach wracks material to invertebrate biomass for aquafeeds. -Bring to TRL6 a process to valorise fisheries bycatchs to create novel food for human consumption NOVAFOODIES will develop a MarketPlatform & Mobile App using IoT technologies and advanced data analysis for tracing & wastes optimisation along the value chain, enhacing consumers trust. Partners are committed to the exploitation of developed technologies, being actively involved in the dissemination & exploitation, as well as education and training activities in local areas to promote sociolaboral inclusion and paving the way to the market entry of new products and processes.

Keywords: algae,fisheries,aquaculture,circular economy,imta,packaging,standardisation,biosecurity,consumer education,training,new business,optimisation,digital integration,new jobs,sustainability
Plankton-like Protocells for Artificial Photosynthesis Targeting Carbon-neutral Energy Vectors (PLANKT-ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 13.0
Total project cost (EUR): 569600.0
EU funding (EUR): 569600.0
Participants: 2
Project status: CLOSED

PLANKT-ON aims to construct and validate a bio-inspired approach to sustainably generate oxygen (O2) and formic acid (FA) based on a bottom-up chemical construction of photosynthetic micro-compartmentalized systems endowed with a structure inspired in the phytoplankton. Plankton-like protocells will contain at their core two types of (photo)catalytic proto-organelles that work synergistically to autonomously produce O2 and FA from sunlight, water (H2O) and carbon dioxide (CO2). We now proposes to elevate the applicability of such artificial organelles by developing 3D polymeric scaffolds with enhanced structural and multi-functional properties for the co-localization of the oxygenic quantasomes and CO2-to-FA specialized proto-organelles. The inclusion of UAVR as a widening partner can be highly valuable for the PLANKT-ON project, complementing the concepts and models that support the work of the project. UAVR proposes the development of highly innovative modular natural polymer-based bioinks comprising the plankton-like protocells. In addition, and as highlighted in the first PLANKT-ON review-meeting and technical assessment, this responds to the necessity of tailored bio-hybrid compartments mitigating the FDH enzyme fragility while leveraging the CO2-to-FA forward equilibrium at the reduction sites to bias the bio-hybrid process towards formate production.
Spectroscopy of molecular Hydrogen Ions for the Metrology of fundAmEntal constants and mass RAtios (SHIMAERA) (SHIMAERA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Precision spectroscopy is a rapidly advancing field, where advanced experimental and theoretical methods converge to measure fundamental constants and test the laws of nature with remarkable accuracy. In this MSCA project, I propose innovative laser spectroscopy experiments in molecular hydrogen ions (MHI) to improve the determination of the proton-to-electron mass ratio, a very important fundamental constant of nature. My current group at LaserLaB Amsterdam and the host research group at the Kastler Brossel Laboratory (LKB) in Paris are both key players in the field. The MHI spectroscopy experiments performed in Amsterdam, combined with the quantum electrodynamics (QED) calculation methods developed at LKB, have enabled an improved determination of the proton-to-electron mass ratio and the electron relative atomic mass. Thanks to these exceptional results, as of 2022 MHI spectroscopy contributes to the definition of the CODATA internationally recommended values of the fundamental physics constants. To improve this further, I will implement Doppler-free laser excitation of an MHI quadrupole and/or two-photon vibrational transition, perform precision laser spectroscopy of the excited transition, and extract an even improved determination of the proton-to-electron mass ratio by comparing the measured transition frequency to the theoretically predicted value. This MSCA fellowship will give me the opportunity to do outstanding research by combining my hands-on expertise in precision spectroscopy with the expertise of the host research group in frequency metrology and QED calculations. It will also give me the perfect platform to foster international collaborations within my personal scientific network and to lay out my longer-term research plans, including developing the first MHI-based optical molecular clock to advance novel applications across science and industry.

Keywords: fundamental constants