Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Recyclable Elastomeric Plastics safely and sUstainably designed and produced via enzymatic Recycling of Post-cOnsumer waSte strEams (REPurpose)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Belgium,Spain,United Kingdom,Germany,Netherlands,Austria,Denmark,Italy,Hungary
Call: Safe- and sustainable-by-design polymeric materials (RIA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 6373176.75
EU funding (EUR): 6058487.0
Participants: 12
Project status: SIGNED

In the REPurpose project, local, post-consumer waste is upcycled to new functional "REP polymers" targeting the high-value market of thermoplastic elastomers that nowadays encounter recycling problems. New building blocks derived from biomass or enzymatically degraded polyolefin or paper and cardboard waste will be incorporated giving the REP polymers unique features: i) tuneable elastomeric properties avoiding the need for additives, ii) production, processing and recycling on existing equipment thus avoiding the need for huge CAPEX investments, iii) controllable degradation in different habitats, and iv) unprecedented indefinite recycling, outcompeting fossil carbon with every recycling step. REPurpose’s X-factor hence lies in the non-fossil content steering REP to higher value than the original plastic waste fractions: the first biodegradable and recyclable elastomeric polycondensates in the world. Combining the functional strength with the leverage in ecology in higher-end applications, will create a considerable market traction when good marketing, production and servicing are surrounding this innovative REPurpose platform. To enable this development, the REPurpose consortium is spanning the value chain from i) waste handler, recyclers and regulatory framework advocates over ii) specialty bio- or waste-based building block producers, iii) technology developers for REP polymerisation, processing and detection, to iv) end users for consumer goods, automotive and building and construction, all advised by experts in safety- and sustainability-by-design, life cycle assessment, business modelling and Responsible Research and Innovation. Four universities and research centres, a non-profit organisation, six SMEs (including two start-ups) from seven EU countries and the UK address the research challenges and pave the way for bringing the innovation to the broad public and creating a resilient and sustainable European plastics industry.

Keywords: polymerisation industrial biotechnology renewable resources circular economy safe and sustainable by design enzymatic recycling plastic waste bio based process
integrated nano-photonic OMICs bio-SENSor for lung cancer (OMICSENS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Italy,France,Spain,Sweden,Switzerland,United Kingdom,Portugal
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2953671.25
EU funding (EUR): 2953671.25
Participants: 8
Project status: SIGNED

OMICSENS aims to develop a radically new omics measurement platform that would be initially applied to improve non-small cell lung cancer (NSCLC) prognosis by ensuring a timely and accurate detection of Tyrosine Kinase Inhibitor (TKI) resistance associated to Epidermal Growth Factor Receptor (EGFR) mutations. Subsequently, OMICSENS will be used to improve prognosis of patients suffering from other types of cancers. OMICSENS targets the creation of the first nano-photonic integrated omics bio-sensor to tackle TKI resistance and improve NSCLC treatment outcome and patient prognosis. Thanks to OMICSENS, we will build a six layers technology comprised of an on-chip embedded infra-red source arrays, an artificial intelligence optimized nano-structured surface for photonic signal enhancement, a functionalized surface of high absorbance to specific analytes, a microfluidics system to deliver the sample, a metamaterial-based photo detector array with optimized quantum efficiency and an AI algorithm enabling analyte quantification. Our miniaturized omics bio-sensor will enable real time and concurrent measurements of omics, compatible with organ-on-chip (OOC) in the future. OOC is one of the most promising bioengineering developments, paving the way to more efficient drug testing and personalized medicine trough digital twinning of a biological system. But OOC is lacking a real-time, integrated bio-sensing technology. OMICSENS proposes a disruptive bio-sensor to bridge this gap. OMICSENS will create a radically new device useful for telehealth, capable of improving medical diagnostics, while fostering a patient-centered approach. To achieve our novel and ambitious objective, we have brought together an interdisciplinary consortium of top-level academics (LMU, UNITN, IBEC, KTH) and SMEs (MW, QAI, 4K-MEMS), including expertise in oncology, bio-engineering, micro-fluidics, biochemistry, MEMS, nano-photonics, computational physics and artificial intelligence.

Keywords: non small cell lung cancer cancer biosensor organ on chip omics metamaterial machine learning
Memory Reimagined: Gender and Intersectionality in Participatory Memory Configuration (MEMORYREIMAGINED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Colombia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2026-08-31
Duration (months): 41.0
Total project cost (EUR): 219074.4
EU funding (EUR): 219074.4
Participants: 2
Project status: SIGNED

In the context of the Colombian peace process, this project undertakes an ethnographic exploration of a communitarian museum developed in cooperation between the Colombian National Museum and an organization of transgender activists in a marginalized neighbourhood of Bogotá. Drawing lessons from this innovative collaboration, MEMORYREIMAGINED investigates the inclusion of gender and intersectionality in participatory initiatives of memory configuration. In the outgoing phase of this fellowship, the ethnographic examination of this process of configuring participatory memory will explore the intersection of different forms of violence (armed, structural, gendered, and postcolonial violence) and will delve into the practices of resistance developed by this project. In the return phase to the host institution, the applicability of the methodology examined in this project in an armed conflict-affected context will be explored in contexts of urban social conflict where intersectional violence and social stigmatization affect the everyday of marginalized populations. Through the co-production of knowledge with participants in the project and the development of knowledge exchange with relevant stakeholders, MEMORYREIMAGINED is a form of applied ethnography that foregrounds marginalized memories and contributes to policy and practitioner knowledge of social engagement in memory institutions. It further highlights the potential of memory initiatives to transform social inequality and reduce the continuation of entangled forms of violence. This project advances the fields of feminist anthropology, peace and conflict studies and museum studies, nurturing the interdisciplinary field of memory studies. The outcomes of this three-year project will serve as both precedent and toolkit for participatory approaches to memory configuration, bringing to European institutions and civil society innovative mechanisms for social inclusion and for the promotion of a culture of peace.

Keywords: memory,gender,lgtbiq,violence,peacebuilding,museum studies,anthropology
Elucidating the networks of immune stromal connections by Perturbation of Immunity in Cancer - towards developing novel therapeutic strategies (EPIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Immune cells monitor and eliminate cancer cells, and thus keep tumors in check along the lifespan of an organism. However, tumors have evolved various mechanisms to avoid immune surveillance. Therefore, understanding these mechanisms and interfering with them to facilitate immune cell eradication of tumor cells is the focus of many successful immunotherapies. However, the efficacy of immunotherapy is limited to only a small fraction of patients and only certain types of cancers. Therefore, it is crucial to understand the immune-tumor interactions to develop new treatments. Moreover, tumor evasion mechanisms interfere with such treatments, as compensatory programs ensue soon after therapeutic intervention. These compensatory programs are not limited to tumor cells, but also occur in the stromal compartment of the tumor microenvironment (TME), which provides indispensable support to the tumor, and is often overlooked as potential target for intervention. Here we aim to gain a fundamental understanding of all cellular networks within the TME, to elucidate the roles and programs carried out by each cellular element participating in the complex, multilevel interactions that occur before therapeutic intervention and afterward. Toward this goal, we will map the entire spectrum of immune and stromal cell interactions in the TME. We will identify negative- and positive-tumor-regulator dependent programs, primary and compensatory, unique and shared-across pathogenic conditions, and cell-intrinsic and extrinsic programs (Aim 1). Additionally, we aim to identify conserved mouse and human pathways using a parallel mouse and human tumor slice culture system (Aim 2). Based on Aims 1 and 2, we will test and validate new candidates for targeted rational combination therapy in-vivo (Aim 3). Our findings will lay the foundations for a fundamental understanding of tumor immunity dynamics in the TME and create a paradigm shift in immunotherapy

Keywords: tumor immunology,immunotherapy,cellular networks,stroma,tumor microenvironment
Tracking impacts of climate change in the Arctic marine ecosystems through cephalopod diversity and life histories (ArCeph)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-15
End date: 2024-05-14
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Climate change is impacting global ecosystems, especially in the polar areas of the Earth. Countering climate change effects is stated as one of the key goals of both global development, in the 2030 Agenda for Sustainable Development, and of regional development, e.g. EU strategy of managing the Arctic. Cephalopoda (Phylum Mollusca) are pivotal components in marine food webs and have life history and physiological characteristics that make them potential winners of climate change. This group, due to their ecology and biology features, such as high abundance coupled with low taxonomic diversity, high degree of opportunism, ecological adaptability, single reproductive cycle and typically a short lifespan, cab ve used to assess and predict climate change-induced shifts of Arctic ecosystems. Thus, the main objective of the Action is to assess biodiversity, life histories and ecological role of cephalopods in the Arctic and their ontogenetic and temporary changes using both well-established and innovative methodologies, in the climate change context. The project addresses this matter via 3 scientific work packages that focus on the following research hypotheses: Hypothesis 1) diversity and distribution of current Arctic cephalopod populations shifts due to climate changes; Hypothesis 2) environmental conditions experienced during the life of individual cephalopods can be documented and used to assess the climate change impact on life histories, where comparing historical with new specimens will highlight climate change impact; and Hypothesis 3) the role of cephalopods in the Arctic food web is even more pivotal then we currently understand, and this would be tested with innovative food web modelling methods. The results achieved will increase the quality of ecological monitoring in the Arctic, leading to more rational management of the Arctic marine ecosystems in order to possibly counter climate change impact.

Keywords: stable isotope analysis,environmantal dna,food web modelling
The PsychoGeography of Intergenerational Mobility: Early life socioeconomic position, mental health, and educational performance (GeoGen)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2158630.0
EU funding (EUR): 2158630.0
Participants: 1
Project status: SIGNED

Surging inequality is a defining feature of the world children grow up in today. The neighborhood they live in stages a primary developmental context where this feature of our present time plays out. Children’s demographic and socio-economic status (SES) is given by the status of their parents. Parental and neighborhood SES is associated with child mental health and educational performance, and childhood is a vulnerable period. To understand how and why early life socioeconomic position is linked to mental health and educational performance, I propose a groundbreaking paradigm generalizing temporal, spatial, social, genetic, and individual levels of inference. I will do this by having genomically similar children growing up in different families at different places at different times. These multitudes of counterfactuals will allow me to jointly evaluate hypotheses on selection and causation and risk and protection factors for mental health and academic outcomes. The GeoGen study will render a new understanding of (a) how transmission of risk is transmitted across generations, (b) how early mental health is an antecedent of academic failure, (c) the interactions between genetic risk and protective contextual factors, and (c) characteristics of schools and neighborhoods that are optimal for children’s psychological development. I will use Norway since 1940 as a laboratory (n=8 400 000) with registries giving full genealogy and year-by-year event data on place of residence, indicators of SES, mental health, and educational performance. Within this, I will nest a population-based cohort study comprising genotyping of families (n=240 000 in 110 000 families) and a wide array of survey data, such as non-cognitive skills. The combination of having data on all people in all schools and neighborhoods over time allows me to do an unprecedented study on the gene-environment interplay between risk and protective factors for mental health and academic outcomes.

Keywords: gene environment interaction,public health,education
Three Indirect Probes of Lyman continuum LEakage from galaxies (TRIPLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Cosmic reionization corresponds to the period in the history of the Universe during which the predominantly neutral intergalactic medium was ionised by the emergence of the first luminous sources. Young stars in primeval galaxies may be the sources of reionization, if the ionising radiation, called Lyman continuum (LyC), that they produce can escape their interstellar medium: the escape fraction of LyC photons from galaxies is one of the main unknowns of reionization studies. This ERC project will contribute to answer this question, by computing from simulated galaxies three indirect diagnostics of LyC leakage that were recently reported in the literature, and comparing the virtual observables with the direct escape of LyC photons from simulated galaxies, and with observations. The first diagnostic for LyC leakage relates the escape of the strongly resonant Lyman-alpha radiation from galaxies to the LyC escape. It was proposed by the PI (Verhamme et al. 2015), and recently validated by observations (Verhamme et al. 2016). The second diagnostic proposes that the strength of Oxygen lines ratios can trace density-bounded interstellar regions. It was the selection criterion for the successful detection of 5 strong Lyman Continuum Emitters from our team (Izotov 2016a,b). The third diagnostic relates the metallic absorption line strengths to the porosity of the absorbing interstellar gas in front of the stars. The increasing opacity of the intergalactic medium with redshift renders direct LyC detections impossible during reionisation. Indirect methods are the only probes of LyC leakage in the distant Universe, and the proposed diagnostics will soon become observables at the redshifts of interest with JWST. They have passed the validation tests, it is now urgent to calibrate these indicators on state-of-the art simulations of galaxy formation. This is the main objective of the proposed project.

Keywords: cosmic reionisation,lyman alpha,resonant line radiation transfer simulations,radiation hydrodynamics simulations,lyman continuum escape from galaxies
VeriDevOps (VeriDevOps)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Finland,Sweden,France,France
Call: Software Technologies (H2020-ICT-2020-1, 2020)
Start date: 2020-10-01
End date: 2024-01-31
Duration (months): 40.0
Total project cost (EUR): 3965332.5
EU funding (EUR): 3965332.5
Participants: 8
Project status: SIGNED

VeriDevOps is about fast, flexible system engineering that efficiently integrates development, delivery, and operations, thus aiming at quality deliveries with short cycle time to address ever evolving challenges. Current system development practices are increasingly based on using both off-the-shelf and legacy components which make such systems prone to security vulnerabilities. Since DevOps is promoting frequent software deliveries, verification methods artifacts should be updated in a timely fashion to cope with the pace of the process. VeriDevOps aims at providing faster feedback loop for verifying the security requirements i.e. confidentiality, integrity, availability, authentication, authorization and other quality attributes of large scale cyber-physical systems. VeriDevOps is focusing on optimizing the security verification activities, by automatically creating verifiable models directly from security requirements, and using these models to check security properties on design models and generate artefacts (such as tests or monitors) that can be used (later on) in the DevOps process. More concretely, we will develop methods and tools for: 1) creating security models from textual specifications using natural language processing, 2) automatic security test creation from security models using model-based testing and model-based mutation testing techniques and 3) generating (intelligent/adaptive, ML-based) security monitors for the operational phases. This brings together early security verification through formal modelling as well as test generation, selection, execution and analysis capabilities to enable companies to deliver quality systems with confidence in a fast-paced DevOps environment. Overall, VeriDevOps is using the results of formal verification of security requirements and design models created during the analysis and design phase for test and monitor generation to be used to enhance the feedback mechanisms during development and operation phases.