Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An Ever Closer Union Among the Peoples of Europe: A Critical Legal History (EPoCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2024-03-04
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

This project aims to provide the first critical legal historical analysis of the iconic opening line of the EU treaties; ‘an ever closer union among the peoples of Europe’. This project will therefore advance the scientific understanding of the origins and meaning of the most well-known phrase of EU law, meant to define European integration. EPoCH is designed to offer a novel account of who was meant to be included and excluded from the ‘ever closer union among the peoples of Europe’, when the phrase was drafted and re-drafted. This is a singularly novel approach, which will advance the state of the art of research on the foundations of EU law, as well as the history of European integration. Evaluating the project of European integration from the point of view of the historical legal standing of the individual within the project itself is important in today’s context of renewed interest in political nationalism and critique of the EU. EPoCH conducts the first ever systematic analysis of the archival material of the Intergovernmental Conferences (IGCs) of the Rome Treaty 1956-57, and of the Maastricht Treaty 1990-91. EPoCH’s specific objectives are, first, to acquire knowledge about the ways in which the choice of ‘peoples of Europe’ was affected by the on-going, yet unravelling, colonialism of the EEC Member States during the drafting of the Rome Treaty in 1956-57. Second, to acquire knowledge about the ways in which individual economic activity was a precondition for the right to EU citizenship, during the drafting of the Maastricht Treaty in 1991-92. This means understanding more about the meaning of the concept of ‘peoples of Europe’ when connected to that of ‘EU citizenship’. Third, to analyse the relation between the micro-histories of the drafting of the Rome and Maastricht treaties concerning who was included and excluded from the ‘ever closer union’, and how that affects the current heightened tension between European integration and the nation state.

Keywords: critical legal history,eu law,european integration,european nationalism
European eXtreme Data and Computing Initiative (EXDCI)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: High Performance Computing
Action type: Coordination and support actions
Countries involved: Germany,Italy,Germany,Italy,Germany,Germany,Spain,Italy,Germany,Slovenia,Sweden,Switzerland,Belgium,France,France,France,Netherlands,United Kingdom,United Kingdom
Call: HPC Ecosystem Development (H2020-FETHPC-2014, 2014)
Start date: 2015-09-01
End date: 2018-02-28
Duration (months): 30.0
Total project cost (EUR): 2551875.0
EU funding (EUR): 2551875.0
Participants: 23
Project status: CLOSED

The three most significant HPC bodies in Europe, PRACE, ETP4HPC and EESI, have come together within EXDCI to coordinate the strategy of the European HPC Ecosystem in order to deliver its objectives. In particular, the project will harmonize the road-mapping and performance monitoring activities of the ecosystem to produce tools for coherent strategy-making and its implementation by: • Producing and aligning roadmaps for HPC Technology and HPC Applications • Measuring the implementation of the European HPC strategy • Building and maintaining relations with other international HPC activities and regions • Supporting the generation of young talent as a crucial element of the development of European HPC In this process, EXDCI will complement the Horizon 2020 calls and projects in the achievement of a globally competitive HPC Ecosystem in Europe. This ecosystem is based on three pillars: HPC Technology Provision, HPC Infrastructure and HPC Application Resources. EXDCI will make sure that: • The three pillars are developed in synergy in order to achieve the strategic goals of the entire Ecosystem • Tools exist for strategy review and definition for all the three pillars – the project will operate a process for the creation of relevant roadmaps and the review of project results in the context of the entire environment The project consortium represents the stakeholders and expertise of all three pillars.

Keywords: high performance computing,european hpc strategy,roadmaps,hpc technology,hpc applications,training,prace,etp4hpc
Feasibility study of a NOvel METAbolic liquid biopsy for cancer therapy monitoring (NO-META)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Netherlands
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Circulating Tumour Cells (CTCs) are strong indicators of the aggressiveness of metastatic cancer and there is strong evidence that CTCs are a reliable prognostic factor in patients with early-stage and metastatic breast cancer. Despite significant efforts, the detection and identification of CTCs in peripheral blood has proven difficult. The key technical challenge is posed by the rarity of tumour cells in blood, with estimates of just one CTC per ~1-10 million white blood cells per millilitre of blood. Up until now, there has been only one FDA-approved CTC enumeration system, CellSearch®, yet this state-of-the-art method suffers from severe limitations. There is an urgent need for new, alternative methods of CTCs enumeration and further characterization to fully realize the potential clinical benefits of CTC analysis. Lowering cost and speed of analysis coupled with ability to isolate CTC for further analysis would have a tremendous effect on diagnostics and treatment of cancer patients. It would provide novel means for early screening of individuals in a certain risk groups, elucidating most promising therapy options and following a chosen treatment and providing a cost-effective way to monitor patients in risk of relapse. Cytofind Diagnostics has developed a radically new method to count and isolate CTCs based on single cell determination of the anomalous metabolic properties of tumour cells (the so-called Warburg effect). Here, we wish to carefully analyze the potential impact of our technology on different parts of the oncology care cycle and establish which market is most suitable for the first introduction of our disruptive technology.

Keywords: cancer,personalized medicine,metabolism
A Citizen Observatory and Innovation Marketplace for Land Use and Land Cover Monitoring (LANDSENSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Innovation actions
Countries involved: Austria,Indonesia,Germany,Germany,Germany,Spain,Austria,Germany,Austria,Belgium,Serbia,Slovenia,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Demonstrating the concept of 'Citizen Observatories' (H2020-SC5-2015-two-stage, 2015)
Start date: 2016-09-01
End date: 2020-12-31
Duration (months): 52.0
Total project cost (EUR): 5751232.66
EU funding (EUR): 5088291.88
Participants: 20
Project status: CLOSED

Currently within the EU’s Earth Observation (EO) monitoring framework, there is a need for low-cost methods for acquiring high quality in-situ data to create accurate and well-validated environmental monitoring products. The aim of the LandSense project is to build a far reaching citizen observatory for Land Use and Land Cover (LULC) monitoring that will also function as a technology innovation marketplace. LandSense will deploy advanced tools, services and resources to mobilize and engage citizens to collect in-situ observations (i.e. ground-based data and visual interpretations of EO imagery). Integrating these citizen-driven in-situ data collections with established authoritative and open access data sources will help reduce costs, extend GEOSS and Copernicus capacities, and support comprehensive environmental monitoring systems. New LandSense services (LandSense Campaigner, FarmLand Support, Change Detector and Quality Assurance & Control) will be deployed in three demonstration cases that will address critical LULC issues in the areas of urbanization, agricultural land use and forest/habitat monitoring. Policy-relevant campaigns will be implemented in close collaboration with multiple stakeholders to ensure that citizen observations contribute to EU-wide environmental governance and decision-making. There will be numerous pathways to citizen empowerment via the LandSense Engagement Platform, i.e. tools for discussion, online voting collaborative mapping, as well as events linked to various campaigns involving public consultation. Simultaneously, to improve Europe’s role in the business of in-situ monitoring, LandSense will create sustainable business models to support market uptake and innovation of its novel added-value products and services.

Keywords: land use,land cover,in situ data,citizen observatories,citizen science,empowerment,environmental monitoring,earth observation geoss,copernicus,in situ data marketplace
Speciation, sources, and fate of atmospheric organic phosphorus over the Mediterranean Sea: A missing piece of the P cycle? (PHOSPHOTRAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-12-21
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Phosphorus is a critical nutrient affecting primary productivity in large areas in oceanic ecosystems. The principal source of externally supplied nutrients in many marine ecosystems is the atmospheric deposition. As the ocean is an important sink of atmospheric CO2, phosphorus through productivity limitation can indirectly affect global warming by removing more CO2 from the atmosphere. The importance of organic P as a potential pool of bioavailable P in the atmosphere is not widely recognized. It is important to note that the only available data in the literature are the atmospheric measurements of phosphate and total phosphorus, while there are almost no data about the organic P, especially over Mediterranean Sea (MS). The main goal of PHOSPHOTRAC is to shed light on the atmospheric organic P chemical identification and to test the hypothesis that the increased acidification of the atmosphere may significantly impact the bioavailability of organic P. PHOSPHOTRAC proposes new methodologies and modern instrumentation for the identification of organic P compounds in the atmosphere. Most of them are implemented for the first time in atmospheric samples, and they will provide new insights into a nutrient cycle of P in MS. Organic P-rich compounds of interest are DNA, RNA, ATP, phytic acid, phospholipids, degradation products of chemical weapons, organophosphate ester flame retardants and organophosphorous pesticides. Further identification of atmospheric organic P sources in the region will be performed by using the chemical analysis data of specific tracers (ergosterol, anhydrosugars, trace metals), with statistical analysis, and implementation of atmospheric transport model TM4-ECPL coupled with the thermodynamic model ISORROPIA-II. The proposed project is highly interdisciplinary as it combines analytical chemistry, biology, and atmospheric modeling in order to address a question of extreme ecological importance related to climate change in the MS.

Keywords: organic phosphorous compounds,atmosphere,chemical speciation,mediterranean sea,bioavailability,atmospheric acidity
Understanding the impact of nanoplastics on the development of neurological disorders (NanoGlia)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 1497193.0
EU funding (EUR): 1497193.0
Participants: 1
Project status: SIGNED

An omnipresent but understudied environmental risk for our immune system is pollution by nano-sized plastics. Plastic particles have been detected in a wide variety of ecosystems and are speculated to enter and spread in the food web all the way to humans. Ingested nanoplastics can translocate from the gut to the lymph and circulatory systems and have the capacity to cross the blood-brain barrier in mammals. It has been recently shown that nanoplastics cause behavioural disorders in fish, and thus may also represent a risk for human health, in particular for brain function. However, the long-term bioavailability and toxicity of nanoplastics in the brain are unknown. Microglia as the main neuroimmune cells have not only a defence function required during inflammatory conditions, but constantly sense and response to environmental changes as part of their housekeeping functions that are essential for neuronal homeostasis. This places microglia at the interface between normal and abnormal brain development and function. In line with this, we have recently discovered that chronic microglial activation causes neurodegeneration. As highly phagocytic cells, microglia internalize nanoplastics reaching the brain. This process might in turn lead to their acute or chronic activation, thereby triggering neurological disorders. In NanoGlia, we will use rodent animal models to investigate behavioural as well as cellular and molecular changes in the brain that occur upon ingestion of nanoplastics. We will further determine nanoplastics-induced developmental reprogramming events in fetal microglia that may influence brain organogenesis and function. Understanding how nanoplastics triggers microglial activation during embryogenesis and postnatal stages and whether this immune activation leads to permanent changes in brain development and function will reveal ground-breaking mechanistic insights into the environmentally triggered pathogenesis of neurological disorders.

Keywords: microglia,developmental neuroimmunology,neuroimmunology
HARNESSING PML NUCLEAR BODIES FOR LEUKAEMIA THERAPY (PML-THERAPY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France,Lebanon
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2400000.0
Participants: 2
Project status: SIGNED

In acute promyelocytic leukaemia (APL), retinoic acid (RA) and Arsenic trioxide (As) bind PML/RARA and promote its degradation. Exploring the mechanistic bases for APL response to the RA/As combination, we found that upon PML/RARA degradation the normal PML allele activates a PML/P53 checkpoint absolutely required for APL cure in mice or patients. Physiologically, PML behaves as an oxidative stress sensor and contributes to redox homeostasis. PML organizes nuclear bodies (NBs), domains that recruit multiple client proteins and may facilitate their post-translational modifications (PTM), particularly conjugation of SUMOs. This somehow controls multiple downstream pathways such as P53, but also RB, HIF1A or interferon (IFN). In APL, NB-disruption blunts P53-driven senescence, contributing to oncogenesis and therapy resistance. Critically, PML expression and/or NB-formation are lost upon many viral infections or during cancer development. The mechanism(s) underlying the selective pressure to loose PML expression in multiple cancers remains incompletely understood. Our aim is to mechanistically dissect PML signalling in vivo and therapeutically restore it in malignancies where it is inactivated. We first propose a broad exploration of PML in mice to identify basal and stress-induced PML PTM and identify the repertoire of proteins sumoylated in a PML- dependent manner. We will generate a series of PML knock-in mutant mice and analyse their P53- regulated redox homeostasis. We will mechanistically explore PML/P53-driven senescence in three leukaemia models where we have evidence for basal or therapy-responsive NB-modulation: acute myeloid leukaemia expressing NPMc and IFN-sensitive Tax- or JAK2-driven leukaemias. We will screen chemical libraries for drugs modulating PML expression and/or NB biogenesis. Finally, we will integrate our findings to elaborate innovative therapeutic strategies based on restoration of the PML/P53 checkpoint in leukaemia with unmet medical needs

Keywords: sumo,therapeutics,arsenic,interferon,post translational modifications
The Fall of 1200BC: The role of migration and conflict in social crises at end of the Bronze Age in South-eastern Europe (THE FALL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Ireland,Denmark
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1998778.75
EU funding (EUR): 1605062.25
Participants: 2
Project status: SIGNED

This project explores changes in migration and conflict at the end of the Bronze Age (ca.1300-1000 BC) and their relevance for understanding the collapse of Europe’s first urban civilisation in the Aegean and proto-urban groups of the Balkans. The objective is to uncover the human face of this turning point in European prehistory by directly tracing the movement of people and the spread of new social practices across cultural boundaries. Hotly debated ancient tales of migrations are tested for the first time using recent advances in genetic and isotopic methods that can measure human mobility. Combined with mortuary research, this will precisely define relations between personal mobility and status, gender, identity and health to explore social scenarios in which people moved between groups. To better understand the context of mobility, the project also evaluates social networks through which cultural traditions moved within and between distinct societies. For this purpose, regionally particular ways for making and using objects are analysed to explore how practices were exchanged and how types of objects shaped, and were shaped by, their new contexts of use. Metalwork is chosen for this research because new forms came to be widely shared across the region during the crisis, and we can employ a novel suite of analytic methods that explore how this material exposes wider social changes. As personal and cultural mobility took place in social landscapes, the changing strategies for controlling access and mobility in settlement organisation are next explored. The character and causes of conflicts arising through these diverse venues for interaction are identified and we assess if they were catalysts for, or consequences of, unstable social systems. THE FALL uses new primary research to test how this interplay between local developments, cultural transmissions and movement of people shaped the processes and events leading to the collapse of these early complex societies

Keywords: migration,bronze age collapse,ancient dna,sea peoples,bronze age warfare,conflict archaeology,prehistoric fortification,defensible sites,archaeometallurgy,metalwork wear analysis
Water Forced in Hydrophobic Nano-Confinement: Tunable Solvent System (WATUSO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 1
Project status: SIGNED

Water is the sustainable solvent of excellence but its high polarity limits the solubility of non-polar compounds. Confinement of water in hydrophobic pores alters its hydrogen bonding structure and related properties such as dielectric constant and solvation power. Whether this special state of confined water can be rendered useful in chemical processes is hitherto underexplored. The original idea of this project is to modulate water solvent properties through hydrophobic nano-confinement. Pressure is applied to force a heterogeneous mixture of poorly soluble molecules and water into hydrophobic nanopores of host material where the lowered polarity of water enhances dissolution. Decompression after reaction causes expulsion of the solution from the pores and spontaneous demixing of reaction products as water returns to its normal polar state. Temporary dissolution enhancement during confinement is expected to be advantageous to chemical reaction and molecular storage. Development of dedicated hydrophobic nanoporous materials and research methodologies providing in situ characterization of confined water, solutes and host material using NMR, EIS, DRS, X-ray and neutron scattering under static and dynamic conditions are key aspects of this project. Nano-confined water offers a potential alternative to compression for storing CH4 and H2 gas, and opens new opportunities for green chemistry such as aqueous phase hydrogenation reactions which benefit from enhanced hydrogen solubility. Unprecedented control in time and space over H2O solvation properties in a WATUSO system will enable new technologies with major scientific and societal impact. WATUSO will lead to new insights in water research and deliver new multi-diagnostic characterization tools. WATUSO could revolutionize chemical manufacturing and gas storage and the concept could spill over to many more solvent-based processes. WATUSO will contribute significantly to a greener, more sustainable chemical industry.

Keywords: tunable solvent system,nano confinement,hydrophobic porous materials