Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Direct remote C-H functionalization in piperidine derivatives (DiPipe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

The transition metal-catalyzed direct functionalization of C-H bonds is a major research topic across the world. However selective (regio-, enantio-, diastereoselective) and efficient functionalization of C(sp3)-H bonds, remains a significant challenge: C(sp3)-H bonds are omnipresent in organic molecules and their dissociation energies are large. The use of directing groups (DGs) “guiding” the metal to specific C-H bonds and allowing intramolecular C-H bond activation, is a recognized general approach to address the selectivity challenge. However, their installation and removal add steps to the overall reaction sequence. This proposal aims to develop unprecedented regio- and diastereoselective transition metal-catalyzed functionalization of piperidine derivatives with haloalkenes making use of transient DGs, installed and removed in situ during catalysis. Access to a large number of substituted piperidines as well as known and new bicyclic scaffolds can be achieved via post-functionalization of the vinylpiperidine reaction products, making the aimed synthetic methodology potentially suitable for molecular library synthesis in drug discovery. A particularly challenging objective of the proposal is the remote (meta) functionalization with respect to the DG at C3 of the piperidine ring. Piperidine is chosen as a central heterocycle core in this application based on its importance in drug design and wide occurrence in commercial drugs (privileged scaffold).

Keywords: c h activation,c h functionalization,directing group,heterocycles,piperidines
Spreading Excellence and Crossing Innovation Divide Conference (SECID)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Slovakia
Call: Presidency Conference: Spreading Excellence and Crossing the Innovation Divide (H2020-IBA-SEWP-INNOVATION-2016-1, 2016)
Start date: 2016-07-01
End date: 2017-03-31
Duration (months): 9.0
Total project cost (EUR): 120000.0
EU funding (EUR): 120000.0
Participants: 1
Project status: CLOSED

The conference Spreading Excellence and Crossing the Innovation Divide will be organised during the Slovak presidency of the Council of the European Union in the second semester of 2016. The event will held in Brussels, Belgium. This conference takes place at an important point in time since the ex-post evaluation of the 7th Framework Programme will be completed and may thus contribute to the overall assessment and reflection on what has been achieved in the effort of the EU to reduce disparities among Member States in terms of performance. In addition, the interim evaluation of Horizon 2020 will be launched and discussions on the future Framework Programme will start to take shape. Furthermore, the first Widening projects under Teaming Twinning and ERA Chairs have started already in 2015 and some examples might be showcased. Among others, the event can follow the results and recommendations resulting from the conference “Young Scientists in Europe” organised during the Dutch presidency and at the same time add other insights. The overall objective of the conference is to provide a platform for stakeholders to have an in-depth discussion on the role of excellence in European research and innovation as well as opportunities presented through Horizon 2020 and ESIF for crossing the innovation gap between countries, regions, research institutions, universities, and enterprises.

Keywords: spreading excellence,crossing innovation divide,widening participation
DOVETAILED MASSIVE WOOD BOARD ELEMENTS FOR MULTI-STORY BUILDINGS (DoMWoB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 202680.96
EU funding (EUR): 202680.96
Participants: 1
Project status: SIGNED

In engineered wood products (EWPs), adhesives play an essential role particularly by helping save wood, making the structure light and robust, and moderating the expansion and contraction due to the inherent moisture. Although there are many advantages associated with EWPs, the use of adhesives causes some concerns about their sustainability, recyclability, and broader environmental impact. In addition to these detrimental substances, metal connectors used in EWPs have a negative impact on their end-of-life disposal, reusability, and recyclability. Thus, there is still room for a solution that is solid and completely pure wood enabling as healthy indoor air as possible (adhesive-&metal-connectors-free) dovetailed massive wood board elements (DMWBE) based on one of the oldest joining methods used traditionally. In the literature, numerous studies have been conducted on the technological, ecological, social, and economic aspects of EWPs in the construction with different building solutions, however, no studies have made an attempt to evaluate the technical performance of DMWBE in multi-story or tall construction. Overall, the aim of this research is to promote the competitiveness of Finnish large-scale industrial wooden construction at the local level and to create higher value-added circular economy opportunities in support of European climate policy as part of the bio-economy and sustainable development. To achieve this goal, DMWBE for multi-story buildings to the global market as a replacement of conventional EWPs e.g. cross-laminated timber, glue-laminated timber will be developed by enabling the confidence of its technical performance and suitability within the interdisciplinary collaborations among architecture, structure, and building physics. The following main objectives have been identified: Designing, building, and testing, and finally conducting market research of DMWBE in multi-story, maybe even tall, construction.

Keywords: wood construction,timber construction,dovetailed massive wood board elements,multi story buildings
Cost-effective and flexible 3D printed SOFC stacks for commercial applications (Cell3Ditor)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Spain,Spain,Sweden,France,Netherlands,Denmark,United Kingdom
Call: Development of cost effective manufacturing technologies for key components or fuel cell systems (H2020-JTI-FCH-2015-1, 2015)
Start date: 2016-07-01
End date: 2020-04-30
Duration (months): 46.0
Total project cost (EUR): 2191133.75
EU funding (EUR): 2180662.5
Participants: 8
Project status: CLOSED

A Solid Oxide Fuel Cell (SOFC) is a ceramic-based multilayer device that involves expensive and time-consuming multi-step manufacturing processes including tape casting, screen printing, firing, shaping and several high-temperature thermal treatments. In addition, these cells are manually assembled into stacks resulting in extra steps for joining and sealing that difficult the standardization and quality control of the final product while introducing weak parts likely to fail. Since current ceramics processing presents strong limitations in shape and extremely complex design for manufacturing (more than 100 steps), industrially fabricated SOFC cells and stacks are expensive and present low flexibility and long time to market. This is particularly relevant for the commercial segment of the stationary fuel cells market (5-400kW) that is highly heterogeneous in terms of the overall power and heat requirements and requires customization of the final product. The main goal of the Cell3Ditor project is to develop a 3D printing technology for the industrial production of SOFC stacks by covering research and innovation in all the stages of the industrial value chain (inks formulation, 3D printer development, ceramics consolidation and system integration). All-ceramic joint-free SOFC stacks with embedded fluidics and current collection will be fabricated in a two-step process (single-step printing and sintering) to reduce in energy, materials and assembly costs while simplifying the design for manufacturing and time to market. Compared to traditional ceramic processing, the Cell3Ditor manufacturing process presents a significantly shorter time to market (from years to months) and a cost reduction estimated in 63% with an initial investment below one third of an equivalent conventional manufacturing plant (production of 1000 units per year). The project is product-driven and involves SMEs (with proved technologies) in the entire value chain to ensure reaching TRL>6.

Keywords: sofc stack,3d printing
laboratory Experiments, Numerical moDellinG and field observAtions of basaltic Magma fragmEntation (ENDGAME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

For low viscosity magmas such as basalts, rapid and unpredictable transitions between effusive and explosive activity may occur. These transitions dramatically alter the impact of an eruption and pose a real challenge to policymakers tasked with mitigating the risks associated with basaltic eruptions. Mechanisms controlling these transitions, however, are not well understood, mainly due to the lack of a clear understanding of basaltic magma fragmentation. The ENDGAME project proposes to investigate transitions in eruptive styles at basaltic volcanoes by studying fragmentation of basaltic magmas through a combination of targeted cutting-edge fluid dynamics experiments, new holistic numerical modelling of magma ascent and brand new field observations collected during a basaltic eruption. ENDGAME will aim to: 1) define new constitutive equations for basaltic magma fragmentation by implementing and performing jet flow and shock-tube experiments with a bubble- and particle-bearing analogue material in combination with high-speed Schlieren shadow photography; 2) extend a state-of-the-art 3D transient model of magma ascent to model the evolution of the particle-size distribution resulting from fragmentation through time by using a numerical technique which has been recently applied in volcanology, the “Method of Moments”; 3) use the new 3D magma ascent model to investigate the transitions in eruptive style by comparing numerical results with laboratory experiments and field observations that will be collected during an eruption at Piton de la Fournaise. The interdisciplinary approach that characterizes ENDGAME, e.g. linking cutting-edge fluid-dynamics experiments with state-of-the-art 3D magma ascent modelling and field observations of an active eruption, will allow us to shed light on one of the biggest challenges in volcanic hazard assessment: what parameters and how they control the transition in eruptive style at basaltic volcanoes?

Keywords: fragmentation,basalt,explosive eruption,magma ascent dynamics,analogue experiments,numerical modelling,fieldwork
The Role of Autophagy in Synaptic Plasticity (NEUROPHAGY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland,Greece
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1493750.0
EU funding (EUR): 925307.19
Participants: 2
Project status: CLOSED

Neuronal metabolism is emerging as an essential regulator of brain function and its deregulation is a common denominator in neurological disorders entailing intellectual disability and synapse dys-morphogenesis. The autophagy-lysosome system is the major catabolic pathway dedicated to the recycling not only of protein aggregates but also lipids, nucleic acids, polysaccharides and defective or superfluous organelles, among others. Appreciation of the role of autophagic pathways in the healthy and diseased brain continues to expand, as accumulating evidence indicates that proper regulation of autophagy is indispensable for neuronal integrity. At the cellular level, several lines of evidence implicate autophagy in the regulation of synaptic plasticity. However, the synapse-specific substrates of autophagy remain elusive. Similarly, the synaptic defects arising from autophagy impairment have never been thus far systematically addressed, yet they translate into severe behavioural deficiencies, such as compromised memory and cognition, pertinent to disorders of intellectual disability. The present proposal aims to determine how autophagy regulates synaptic plasticity and how its deregulation contributes to synaptic defects. In particular, the objectives aim to: 1) Monitor and characterize the presence of the autophagic machinery in pre- and post-synaptic sites. 2) Identify autophagic substrates residing in synapses and whose turnover via autophagy determines synaptic plasticity. 3) Characterize the synaptic defects and ensuing behavioural deficits arising from impaired autophagy in the hippocampus. 4) Use C. elegans as a model system to address the evolutionary conservation of the synaptic role of autophagy and perform forward genetic screens to reveal novel regulators of autophagy in synapses.

Keywords: metabolism,dendritic spines,forward genetic screens
World class Science and Innovation with Neutrons in Europe 2020 – SINE2020 (SINE2020)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Germany,Spain,Spain,Sweden,Switzerland,Hungary,France,France,Czechia,Netherlands,Denmark,Denmark,United Kingdom,Portugal
Call: Implementation and operation of cross-cutting services and solutions for clusters of ESFRI and other relevant research infrastructure initiatives (H2020-INFRADEV-1-2014-1, 2014)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 12080866.25
EU funding (EUR): 10863447.0
Participants: 20
Project status: CLOSED

Today’s society is being transformed by new materials and processes. Analytical techniques underpin their development and neutrons, with their unique properties, play a pivotal role in a multi-disciplinary, knowledge-based approach. Industry and the neutron research community must however work together more closely to enhance their innovation potential. Neutrons are only available at large scale facilities (LSF’s), presenting specific challenges for outreach. National and European initiatives have combined to create a user community of almost 10000, mainly academia-based users, which is supported by an ecosystem of about 10, often world-class national facilities and the European facility, the Institute Laue Langevin. Europe leads neutron science and is investing almost 2B€ in the European Spallation Source (ESS), its construction, like Horizon 2020, spanning the period 2014-2020. SINE2020, world-class Science and Innovation with Neutrons in Europe in 2020, is therefore a project with two objectives; preparing Europe for the unique opportunities at ESS in 2020 and developing the innovation potential of neutron LSF’s. Common services underpin the European research area for neutrons. New and improved services will be developed in SINE2020, by the LSF’s and partners in 13 countries, in a holistic approach including outreach, samples, instrumentation and software. These services are the key to integrating ESS in the European neutron ecosystem, ensuring scientific success from day one. They are also the basis for facilitating direct use of neutron LSF’s by industry. Particular emphasis is placed on the industry consultancy, which will reach out to industry and develop a business model for direct, industry use of LSF’s in 2020, and data treatment, exploiting a game-changing opportunity at LSF’s to adopt a common software approach in the production of scientific results.

Keywords: neutrons,innovation potential,industry,data,analysis software,e learning,sample,chemical deuteration,crystal growth,e science,instrumentation simulation,detector technology
Engineered Capillary Beds for Successful Prevascularization of Tissue Engineering Constructs (CapBed)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2025-04-30
Duration (months): 78.0
Total project cost (EUR): 1499940.0
EU funding (EUR): 1499940.0
Participants: 1
Project status: SIGNED

The demand for donated organs vastly outnumbers the supply, leading each year to the death of thousands of people and the suffering of millions more. Engineered tissues and organs following Tissue Engineering approaches are a possible solution to this problem. However, a prevascularization solution to irrigate complex engineered tissues and assure their survival after transplantation is currently elusive. In the human body, complex organs and tissues irrigation is achieved by a network of blood vessels termed capillary bed which suggests such a structure is needed in engineered tissues. Previous approaches to engineer capillary beds reached different levels of success but none yielded a fully functional one due to the inability in simultaneously addressing key elements such as correct angiogenic cell populations, a suitable matrix and dynamic conditions that mimic blood flow. CapBed aims at proposing a new technology to fabricate in vitro capillary beds that include a vascular axis that can be anastomosed with a patient circulation. Such capillary beds could be used as prime tools to prevascularize in vitro engineered tissues and provide fast perfusion of those after transplantation to a patient. Cutting edge techniques will be for the first time integrated in a disruptive approach to address the requirements listed above. Angiogenic cell sheets of human Adipose-derived Stromal Vascular fraction cells will provide the cell populations that integrate the capillaries and manage its intricate formation, as well as the collagen required to build the matrix that will hold the capillary beds. Innovative fabrication technologies such as 3D printing and laser photoablation will be used for the fabrication of the micropatterned matrix that will allow fluid flow through microfluidics. The resulting functional capillary beds can be used with virtually every tissue engineering strategy rendering the proposed strategy with massive economical, scientific and medical potential

Keywords: capillary bed,angiogenesis,3d printing,laser photoablation,cell sheet engineering,adipose derived stromal vascular fraction,microfluidics
A novel, modular, smart and patient-centred Ankle-Foot-Orthosis design and production process (MOWA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

By 2020, up to 23 million EU citizens will suffer from a neuromuscular disorder resulting in gait disabilities such as the foot drop syndrome, a condition that causes patients often stumbling and even falling. Ankle foot orthoses (AFO) are widely used to help these patients. The objective is to fully support or restore patient’s mobility, so the orthosis must be designed to match patients’ anatomy and therapeutic needs, a constantly changing pattern in most of the patients with neuromuscular diseases. Nowadays, the manufacture of adapted orthoses is still a manual procedure highly dependent on the orthopaedist expertise, resulting in a long and expensive process, often traumatic for patients, especially children. With the aim of offering to our neuro- orthopaedic patients the best treatment and support during the mobility recovery therapy, we have developed MOWA, an innovative ankle-food-orthosis (AFO) with an associated design and production process fully digitalised that fully exploits the benefits of big data and machine learning enabling a fast and cost-efficient production of customised orthoses. MOWA uniqueness relies on the digitalisation of the design and manufacture steps so that each component is individually produced, thus the orthosis perfectly fits patients’ anatomy and optimally supports their walking. In addition, the orthosis can be easily reproduced, something especially relevant for children, who need to replace their orthosis twice a year so that it grows with them. Custom-made orthoses will play a key role within the global orthotics market, which was valued at €2,750 million in 2016, and is projected to grow at a CAGR=5.8% until 2023. MOWA’s Total Addressable Market in 2020 is expected to surpass the 320,000 units, with an associate value of €256 million. In addition, MOWA will boost the growth of our company with revenues surpassing the €20 million in the 3rd year after market uptake and the creation of up to 20 new positions.

Keywords: orthosis,walking disorder,neuromuscular disorder,foot drop syndrome