Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Environmental chemicals as obesogens (OBESOGENS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-06-30
Duration (months): 36.0
Total project cost (EUR): 249490.8
EU funding (EUR): 249490.8
Participants: 2
Project status: CLOSED

Obesity is a serious health risk that has reached epidemic proportions worldwide. Obesity is traditionally considered a as disorder of energy imbalance imposed on a background of genetic disposition. In addition to risk factors such as diet and genetics, chemicals in our environment have emerged as contributing factors associated with an increased risk for obesity (i.e. obesogens). Phthalate esters, a ubiquitous class of chemicals used as plasticizers in products such as toys and hospital supplies, are suspected of being obesogens. Despite studies demonstrating that phthalate urine levels are associated with increased risk to obesity in children, meta-analyses report that current data are insufficient for determining whether phthalates do in fact increase the prevalence of obesity. Moreover, data are sparse on how obesogens affect metabolism and the feeding axis and there are fundamental gaps in our understanding of the precise mechanisms by which environmental chemicals exacerbate this human disease. The central hypothesis of this proposal is that exposures to phthalates will exacerbate molecular responses in the hypothalamus and gut that are observed during a regime of over-feeding. Further, the modification of the gut microbiota may be a relevant consequence of obesogens. The zebrafish (ZF) is one of the most important models in environmental toxicology and developmental biology, and is rapidly becoming a major model for studies in human health and metabolic diseases. ZF will be used to determine mechanisms that are associated to diet and chemical induced obesity, novel regulatory pathways in the hypothalamus and gut will be identified; this is important as these two tissues communicate via the endocrine system and there is direct innervation of the gut by the central nervous system. To be in line with 3R principles, high throughput screen method using ZF embryo will be developed to test environmental chemicals for their “obesogenic” potential.

Keywords: obesogens,obesity,phthalates,zebrafish,hypothalamus,gut microbiota
Cost-Efficient Network for the Genetic Certification of Food Quality (SeQfood)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SeQfood project aims to provide the first tool for verifiable product authenticity certification and traceability along the food chain; also being the first electronic network for the genetic certification of food products. The invention relies on our proprietary Genowas-GENOMID fingerprinting technology, a smart system for agrifood certification and labeling by means of 2DNA codes which provide reliable, unique and forgery-proof information of identity, composition and geographical origin. Product´s information will be freely available in the SeQfood web, increasing transparency and consumer´s confidence. SeQfood will result on added value for high-quality products, but also simplifying logistics and traceability. Another powerful novelty is that costs and delivery time are comparable to PCR techniques but our solution provides greater information in a one-step assay. SeQfood represents an essential pillar for the company´s growth since by its commercialization the company will be able to penetrate the growing food traceability market and consolidate its position in the fields of genomics, proteomics and metabolomics. To ensure the successful market launch, our company will conduct a robust feasibility study and a business plan where main technical, commercial and financial resources and requirements will be deeply analyzed. SeQfood is in line with one of the present Societal Challenges of the European Commission addressing “Sustainable and competitive agri-food sector for a safe and healthy diet”, since it will serve as the first verifiable, standardized and free-access tool for warranting food safety, quality and traceability from production to consumption, and vice verse. This will improve food fraud prevention while also promoting high-quality authentic products, which is crucial to assure the commercial success of European high-value agrifood products on international markets, as well as to ensure that consumer’ rights and health are protected.

Keywords: food traceability,food fraud,high quality products,genetic certification,product authenticity
CYprus Promotes RESearch and Science (CYPRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Cyprus
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-05-09
End date: 2017-11-08
Duration (months): 18.0
Total project cost (EUR): 192000.0
EU funding (EUR): 140000.0
Participants: 1
Project status: CLOSED

The proposal “CYPRESS”, standing for “CYprus Promotes RESearch and Science”, aims at organising two Researchers’ Night events, one in 2016 in Nicosia, celebrating the 10 years of the events in Cyprus and one in 2017 in Limassol, focusing on Cultural Heritage Research, on the occasion of Pafos being the European Capital of Culture. CYPRESS’ Coordinator, the Research Promotion Foundation (RPF), as the National Agency for supporting Research and Innovation (R&I), has within its remit gained a long experience in organising activities for the promotion of R&I towards the public and especially the younger generation, with the Researchers’ Night events being an integral part of its philosophy since 2006, with or without EC support, but always with vivid support from the National Research System. RPF has secured the collaboration of all Universities in Cyprus, the major Research Institutes and Centres, R&I-intensive Enterprises (mainly SMEs), Public Authorities, End Users and the Civil Society and for the first time Industrialist and Employers’ Associations, covering the Quadruple Helix of Innovation in a complementary way. As a novelty, RPF will also utilise a bottom up approach to attract new partners and will establish links with international partners. Building on past experiences, CYPRESS will bring together researchers from all sectors and disciplines, along with the public, increasing appreciation of the researchers’ work, raising awareness on the importance of R&I for society and the economy and motivating children to take up a career in research. Through a balanced mix of educational and entertaining, interactive activities, aiming at people of all ages, genders and educational backgrounds, and with the contribution of volunteers from the partners and RPF, the events will celebrate R&I achievements, especially EU funded and will ultimately remove stereotypes about the researchers’ profession, creating a much needed R&I culture among the Cypriot population.

Keywords: researchers night,science communication,marie sklodowska curie actions
Astroparticle and Oscillations Research with Cosmics in the Abyss (ARCA and ORCA) (KM3NeT - INFRADEV)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Greece,France,Netherlands
Call: Preparatory Phase and support to early phase of ESFRI projects (H2020-INFRADEV-2016-2, 2016)
Start date: 2017-01-01
End date: 2020-10-31
Duration (months): 46.0
Total project cost (EUR): 3795000.0
EU funding (EUR): 3795000.0
Participants: 6
Project status: CLOSED

KM3NeT is a large Research Infrastructure that will consist of a network of deep-sea neutrino telescopes in the Mediterranean Sea with user ports for earth and sea sciences. The main science objectives, a description of the technology and a summary of the costs are presented in the KM3NeT 2.0 Letter of Intent. Following the appearance of KM3NeT 2.0 on the ESFRI roadmap 2016 and in line with the recommendations of the Assessment Expert Group in 2013, this proposal addresses the Coordination and Support Actions (CSA) to prepare a legal entity for KM3NeT, thereby providing a sustainable solution for the operation of the Research Infrastructure during ten (or more) years. During the EU-funded Design Study (2006 - 2010) and Preparatory Phase (2008-2012), a cost-effective technology was developed, deep-sea sites were selected and the Collaboration was formed. This proposal constitutes a second Preparatory Phase. The project will be carried out within the context of the current KM3NeT Collaboration which already has a provisional implementation of the management and governance of the Research Infrastructure in place. The resources requested will be complemented by the Collaboration.

Keywords: neutrino telescope,deep sea research infrastructure,legal entity,value added services
How intraflagellar transport shapes the cilium: a single-molecule systems study (HITSCIL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-05-31
Duration (months): 69.0
Total project cost (EUR): 2499580.0
EU funding (EUR): 2499580.0
Participants: 1
Project status: SIGNED

Sensory cilia are organelles extending like antennas from many eukaryotic cells, with crucial functions in sensing and signalling. Cilia consist of an axoneme built of microtubules, enveloped by a specialized membrane. Ciliary development and maintenance depend critically on a specific, microtubule-based intracellular transport mechanism, intraflagellar transport (IFT). In my laboratory, we study the chemosensory cilia of C. elegans, which sense water-soluble molecules in the animal’s environment for chemotaxis. Over the past years, we have developed a unique set of quantitative, single-molecule fluorescence microscopy tools that allow us to visualize and quantify IFT dynamics with unprecedented detail in living animals. So far, our focus has been on the cooperation of the motor proteins driving IFT. The overall objective of my current proposal is to zoom out and shed light on the connection between ciliary structure, chemosensory function and IFT, from a systems perspective. Recent work has indicated that axoneme length is controlled by IFT. Preliminary results from my laboratory show that axoneme length changes dynamically in response to perturbations of IFT or cilia. Furthermore, we have shown that IFT is substantially affected upon exposure of animals to known repellent solutions. The four major aims in my proposal are to: • determine how directional changes in IFT are regulated and are affected by external disturbances, • understand the dynamics of the axonemal microtubules and how IFT affects these dynamics and vice versa, • study how sensory ciliary function affects IFT and ciliary structure, • further develop our (single-molecule) fluorescence microscopy toolbox by improving instrumentation and using better fluorescent probes and sensors. These experiments will place my lab in a unique position to push forward our understanding of the relationship between structure, function and dynamics of transport of this fascinating and fundamental organelle.

Keywords: single molecule fluorescence,intraflagellar transport,cilia
Investigating interactions between plant roots and phosphorus in soil (RootOutP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

Phosphorus (P) is a scarce resource that is critical for crop production, but it is not being used sustainably. Excessive past fertiliser applications mean large amounts of P have accumulated in soil, losses of which are of major environmental concern. Nonetheless, the majority of soil-P exists in pools of very low bioavailability to plants, due to the high reactivity of P in soil. Increasing the ability of plants to take up P from applied sources (fertilisers) and from accumulated soil reserves would allow for reductions of fertiliser use and decreased potential P losses to the environment. Through evolution, plant roots have adopted several strategies to improve P capture, including: 1) architectural traits that affect the spatial exploration of the soil profile; 2) adaptive (plastic) responses to zones of high P supply (e.g. around fertiliser granules); and 3) physiochemical alteration of the environment in their rhizosphere. A challenge for the research community is to evaluate these properties and their potential benefits to cropping systems. As soil is inherently opaque, these traits are hard to study. Our current knowledge is fragmented because studies have generally used destructive sampling techniques, artificial media, and experimental setups making observations in 1D or 2D. Further advances of our understanding require in-situ visualization and quantification in real soil. This project will deliver such in-situ information, relevant to breeders and agronomists developing crop systems that make better use of applied and accumulated soil P. I will carry out this research under the guidance of Assoc. Prof. Sander Bruun of the Dept. of Plant and Environmental sciences at Copenhagen University and I will make use of the National X-Ray Imaging Facility (DANFIX) and the Center for Quantification of Imaging Data (QIM). I will undertake a secondment with Dr Jakob Santner at the Institute of Agronomy of the University of Natural Resources and Life Sciences, Vienna

Keywords: plant soil interactions,in situ,plant roots,phosphorus availability,phosphorus chemistry,fertiliser placement,soil heterogeneity,root architecture and development,root exudation
Fully Adaptive Simulation Tool for Kinetic Theory (FASTKiT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

Kinetic models are omnipresent in a wide range of scientific and engineering applications. They are derived from the evolution of a particle distribution in position-velocity phase space, and appear, for instance, in the modeling of fusion energy reactors and atmospheric reentry of spacecraft, where classical fluid equations are inaccurate. Further technological progress of these applications requires significant advances in modeling and simulation of kinetic models. The underlying kinetic equations pose severe simulation challenges, due to their inherent high-dimensionality and the presence of a wide range of time scales. The increased dimensionality in velocity directions can be addressed by an extended set of fluid quantities via moment models or the maximum entropy method. To deal with the stiffness of the equations, asymptotic-preserving time discretization methods need to be used. Since both the stiffness and the accuracy of a kinetic model depend on space and time, the design of numerical methods incorporating fully integrated space-time adaptivity is crucial to allow these methods to be efficiently used in real-world applications. In this action, the applicant will integrate his expertise on moment models with the experience on projective integration schemes available at the host institution, and extend their applicability towards a wide range of kinetic models hereby achieving the following objectives: - Develop fully space-time adaptive numerical scheme for kinetic models - Implement software for space-time adaptive solution of kinetic models - Compute numerical solutions for real-world applications The results of FASTKiT will constitute a major step forward in the adaptive simulation of kinetic models. FASTKiT will contribute to the development of technologies for next generation reactors and space exploration efforts, in line with Horizon 2020, while the applicant will benefit from an innovative environment to receive training and transferable skills.

Keywords: kinetic theory,time integration,adaptivity,multi scale,asymptotic preserving,moment method
PhD Programme of Advanced Research in Interdisciplinary Science at ESPCI Paris (UPtoPARIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France,France
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 4708800.0
EU funding (EUR): 2354400.0
Participants: 2
Project status: CLOSED

Loyal to its tradition in education and training on an interdisciplinary level between physics, chemistry and biology, ESPCI proposes a brand new international doctoral programme – UPtoPARIS. PhD fellows will have the opportunity to explore a unique environment comprising an elite engineer school, 9 joint research units and a new incubator on campus hosting 12 technology-driven start-ups – a recipe for a cutting-edge doctoral training in the heart of Paris. UPtoPARIS is designed to propose a combination of research activities and innovative and competitive supervising, mentoring and career planning. With PhD projects strongly connected to the transferability of basic science, the programme aims to shape new profiles of forward-looking young researchers by giving them knowledge and skills directly linked to the needs of the European and international industry and market. The intersectoral exposure, provided by secondments, workshops and specific guidance, will help young researchers to gain a precious experience in terms of technological development and application through consciously selected topics of European interest, inspired by the KETs, identified by the EU. The 5 Education and Research Chairs of ESPCI (Total, Michelin, Saint-Gobain, Axa and Safran) are also a guarantee for the privileged long-term partnerships with the industry. The 30 incoming excellent doctoral candidates will also reinforce the internationally renowned profile of ESPCI and the region, by increasing the number of foreign PhD students and, consequently, the quality and the diversity of the scientific exchange. The UPtoParis programme will be a pilot project in terms of better recruitment and career guidance procedures with an important impact on the development of high-quality human resources not only on a local level, but also in the European Research Area.

Keywords: condensed matter,material sciences,hydrodynamics,physical mechanics,nanosciences,soft matter physics,physical chemistry,biology,biotechnology,neuroscience,waves physics,acoutics,photonics
Using periodic orbits to quantitatively describe and control 3D fluid turbulence. (PERTURB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1999830.0
EU funding (EUR): 1999830.0
Participants: 1
Project status: SIGNED

Fluid turbulence is of key importance in engineering: it controls the drag on aircraft, is a major contributor to unwanted energy dissipation in pipelines, yet mixing of chemicals relies on it. Despite its importance, our understanding of turbulence is incomplete. Controlling turbulent flows, which would lead to significant efficiencies for industrial applications, remains a challenge. The recent identification of unstable non-chaotic solutions of the Navier-Stokes equations suggests a promising framework to study the phenomenon. Here turbulence is viewed as a chaotic walk through a forest of exact solutions in the infinite-dimensional state space of the flow equations. While this dynamical systems approach helps rationalizing features of the transition to turbulence, it has so far failed to deliver on the promise it carried since the identification of deterministic chaos in the mid 20th century: To provide a predictive description of turbulence in terms of exact solutions and to act as a rational basis for controlling flows. The major road block to fulfilling the promise is that we are missing tools to identify enough dynamically relevant exact solutions. These are time-periodic non-chaotic solutions that allow us to express statistical properties of turbulence as a weighted average over periodic orbits. Owing to the exponential error amplification in a chaotic system, periodic obits for 3D flows have been almost inaccessible. Instead, research has focused on isolated steady solutions that resemble features of the flow but are dynamically less informative. We will remove the road block and construct extensive libraries of periodic orbits for two canonical 3D flows, turbulent convection and channel flow. By combining variational methods with machine learning tools we will automatically compute periodic orbits of the 3D Navier-Stokes equations. Using periodic orbit theory, we will describe and control flow properties including heat transport and turbulent drag.

Keywords: turbulence,nonlinear dynamics methods,novel numerical methods