Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cell type-specific endometrial dysfunctions across the menstrual cycle and their potential for drug interventions in polycystic ovary syndrome (POTRET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-08-01
End date: 2028-07-31
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

Polycystic ovary syndrome (PCOS) affects 11-13% of reproductive-age women and is one of the leading causes of anovulatory infertility. Women with PCOS have elevated androgen levels, polycystic ovarian morphology, and ovarian dysfunction. The PCOS endometrium is exposed to constant estrogen, which leads to progesterone resistance and impaired decidualization. As a result, PCOS women are twice as likely to have a non-receptive endometrium. This hinders embryo implantation and increases the risk of pregnancy complications, such as miscarriage. However, whether changes in the cellular complexity and heterogeneity of the endometrium during the menstrual cycle contribute to PCOS-specific endometrial dysfunction remains unclear. The overarching aim of this MSCA-PF project is to uncover PCOS and cell type-specific endometrial dysfunction across the menstrual cycle at the single cell level and to test whether the identified markers can serve as targets for future drug development. Using a unique collection of human endometrial biopsies from women with and without PCOS and single nuclei RNA sequencing, I will (1) map the endometrium at the single-cell level at four different menstrual stages, define the composition of cell types and key molecular regulatory networks; (2) establish and characterize 3D mono- and co-culture models of patients endometrium and investigate their ability to mimic tissue of origin; and (3) determine factors that facilitate PCOS-specific epithelial-stroma communication and endometrial response to novel drug treatments. By accomplishing these goals and sharing the transcriptomic data as a PCOS endometrial cell atlas and protocols for patient-derived cell models, the proposed project will provide valuable resources for new discoveries. Ultimately, the project aims to improve the diagnosis, treatment, and prevention of endometrial dysfunction in PCOS. Further, it provides me with a strong training path towards academic independence in Europe.

Keywords: polycystic ovary syndrome,endometrium,single nuclei rna sequencing,three dimensional endometrial epithelial organoids,microfluidics
Multiscale Ocean models and Information for climate Risk Assessment and Impact mitigation (MOIRAI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Greece,Denmark,Spain,Italy,Germany,Netherlands
Call: Ocean models for seasonal to decadal regional climate impacts and feedbacks (HORIZON-CL6-2024-CLIMATE-01, 2024)
Start date: 2024-11-01
End date: 2028-04-30
Duration (months): 42.0
Total project cost (EUR): 4499160.0
EU funding (EUR): 4499160.0
Participants: 15
Project status: SIGNED

MOIRAI, named after the three Greek goddesses of fate, stands as a pioneering project at the intersection of past, present, and future. MOIRAI endeavors to weave a comprehensive understanding of the ocean's dynamics and biogeochemical cycles through advanced models, integrating historical data, current observations, and future projections. Integrated into the frameworks of Destination Earth (DE) and the European Digital Twin of the Ocean (DTO), key components of the broader Digital and Green transitions, MOIRAI aims to significantly advance our comprehension and mitigation of climate-related challenges. MOIRAI is set to advance the next generation of regional to coastal ocean and biogeochemical climate models in European seas, bridging the gaps between operational and regional ocean climate models. Benchmarked with improved climate modelling and prediction capacities in the estuarial-coastal-open sea continuum, the developed models will contribute to the European Green Deal, addressing resilience to climate change (both mitigation and adaptation) in coastal areas. The quality of its coastal models forms the backbone of MOIRAI's commitment to delivering reliable outcomes for end-users. At its core, MOIRAI, in conjunction with the establishment of REASSHORE (Resilience and Adaptation Strategies Selection Hub for Ocean risks Assessment and End-users feedback), aims to create replicable scientific frameworks and pave the way for basin-scale services, fostering collaborative initiatives across European regional seas. Designed to be modular and interoperable, REASSHORE will seamlessly integrate with existing and future digital infrastructures for ocean climate and risk services.

Keywords: extreme events,vulnerability,resilience,aquaculture,multi scale,artificial intelligence,early warning,fisheries,offshore energy,multi use,arctic,inter basin exchange,marine ecosystem model
Strengthening Ecosystem-based Assessment and Monitoring for Protected Habitats in Offshore areas and Newly Identified MPAs (SEAMPHONI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Spain,Germany,Ireland,Denmark,Norway,Portugal,Belgium,Netherlands,Austria,Slovakia,France,Türkiye,Bonaire, Sint Eustatius and Saba
Call: European Blue Parks – Offshore marine protected areas (HORIZON-MISS-2024-OCEAN-01, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 12100582.5
EU funding (EUR): 11095368.75
Participants: 24
Project status: SIGNED

SEAMPHONI is dedicated to bringing visibility and safeguarding the vast and largely unprotected offshore marine areas. Current approaches to offshore biodiversity mapping are highly dependent on research vessels and are therefore costly and do not allow for continuous monitoring. SEAMPHONI is structured to promote the testing, coupling, and validation of three innovative monitoring solutions (environmental DNA (eDNA), acoustics, and imaging) and to build a shared observing system for scientists, decision-makers, MPA managers, and citizens in the form of an Intelligent Marine Digital Twin interoperable with the European Digital Twin Ocean. By leveraging and adapting these cutting-edge tools for offshore areas, SEAMPHONI will provide significant advancement towards a broader, more accurate mapping of European seas with baselines for understudied areas; faster, more continuous biodiversity monitoring; and more accurate, predictive, and sustainable models. This will help identify and prioritize areas to be protected and improve evidence-based assessments of i) the health of marine ecosystems and ii) the effects of various levels of protection and restoration measures on their functioning and services. SEAMPHONI will also tackle the complexity of the regulatory framework governing marine conservation and the fragmentation of rights within these zones, by evaluating limitations and underlining the need for clearer frameworks and improved coordination. The project will support the enforcement of Particularly Sensitive Sea Areas (PSSAs), and advance the 2030 GBF targets. Finally, SEAMPHONI will address the “emotional disconnect between society and aquatic ecosystems” (EC report, 2021) especially in offshore areas where the principle of "out of sight, out of mind" is most pronounced. Confronted with the challenges of engaging citizens in remote offshore areas, where traditional citizen science approaches are impractical, SEAMPHONI has embraced an artistic strategy.

Keywords: deep sea edna acoustic,ai cost efficient outermost regions arctic tropical models ecosystem services food web art imaging expedition strict protection noise pollution blueprints
A clinical research network to improve the management of Monkeypox virus disease (MPX-RESPONSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: Research and Innovation actions
Countries involved: France,Norway,Italy,Spain,Netherlands,Belgium,Brazil,Switzerland,Argentina
Call: Clinical research response to the monkeypox public health emergency of international concern (HORIZON-HLTH-2022-MPX-14, 2022)
Start date: 2022-08-05
End date: 2026-08-04
Duration (months): 48.0
Total project cost (EUR): 11999999.3
EU funding (EUR): 11999999.3
Participants: 17
Project status: SIGNED

The 2022 Monkeypox outbreak is unprecedented in scale and cases are still active in South America and starting to appear in South-East Asia. Many questions about Monkeypox virus disease remain unanswered to this day, particularly concerning the management of patients. MPX-RESPONSE aims to increase our knowledge of the monkeypox virus disease, to improve its therapeutic management and to further inform public health policies and guidelines through four Work Packages (WP). WP2 (MOSAIC) will assess clinical and virological outcomes of Monkeypox patients treated or not with antiviral drugs, focusing treatment on the most severe cases. WPs 3 and 4 will conduct randomized clinical trials (RCT) with the most promising antiviral therapy, tecovirimat, targeting patients in Europe (WP3-EPOXI) and globally in collaboration with WHO (WP4-UNITY); particularly in mild and moderate cases. A common primary outcome will be shared between the two RCTs and EPOXI will include additional objectives regarding pharmacological, immunological and virological outcomes in six to ten EU/EEA countries and fulfill in particular EMA requirements for treatment authorisation. A continuous systematic review and individual patient meta-analysis will summarize all randomized evidence of the interventions for monkeypox. Finally, the project will make sure that acquired knowledge is integrated into public health policies and guidelines and that adequate messages are shared with the general public and high-risk populations with the help of patients’ representatives and associations (WP1-COORDINATE). To accomplish these objectives, MPX-RESPONSE will build on the expertise and networks of multiples partners including Ecraid and EU-RESPONSE and will reinforce and broaden Europe’s capacity to respond rapidly to public health emergencies.

Keywords: monkeypox,clinical trials,epidemic,tecovirimat,randomized controlled trials,data sharing,antiviral drugs,treatment,networks,policy,therapeutic management
Towards ultra-high dose rates in proton therapy: an ionoacoustic approach for in vivo dose monitoring (RAPID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 285140.64
EU funding (EUR): 285140.64
Participants: 3
Project status: SIGNED

The use of ultra-high dose rates (FLASH) in radiation therapy has emerged as a promising modality to treat cancer due to its unprecedented ability to reduce healthy tissue toxicity while ensuring tumor control. “Towards ultra-high dose RAtes in Proton therapy: an Ionoacoustic approach for in vivo Dose monitoring” (RAPID) project aims at providing new insights into the clinical benefits of proton FLASH radiotherapy by resolving the challenge of real-time dose monitoring. The action represents a powerful instrument to push the boundaries of cancer care with proton radiotherapy at three different levels: i) the optimization of an ionoacoustic imaging system for real-time pulse-based 3D dose monitoring, ii) the experimental evaluation of the physical requirements to achieve the FLASH effect by in vivo and in vitro studies under different beam conditions, and iii) the interpretation and optimization of the ionoacoustic signal response for different treatment plans. The ionoacoustic imaging technique, combined with an ultrasound system, will enable to image simultaneously tissue morphology and dose deposition of the beam. These technological advances will disentangle the complex and multiple variables influencing the yet unknown FLASH effect, as well as enabling the first systematic study combining FLASH dosimetry and tissue damage/toxicity response. The researcher will spend 24 months at the Department of Radiation Oncology at Massachusetts General Hospital and Harvard Medical School (Boston, USA) and 12 months at the Department of Atomic, Molecular and Nuclear Physics at University of Seville (USE, Spain) and Centro Nacional de Aceleradores – National Center of Accelerators, an USE joint research center.

Keywords: proton therapy,flash,dose monitoring,ionoacoustic
Multiphoton imaging with computational specificity (MICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2026-06-30
Duration (months): 37.0
Total project cost (EUR): 192125.76
EU funding (EUR): 192125.76
Participants: 2
Project status: SIGNED

Digital staining based on machine learning models can provide cellular specificity to label-free optical imaging. This concept is particularly interesting for in vivo applications in fundamental research of auto-immune diseases as well as for future clinical translations. In this project “MICS – Multiphoton imaging with computational specificity”, I will develop and implement computational specificity for label-free multiphoton microscopy (MPM) using artificial intelligence (AI). The direct outcome of this project will be two AI modules to perform (i) automated classification of mucosal inflammation based on 3D images from colon tissue and (ii) digital staining of un-stained immune cells. This integration of computational specificity to label-free multiphoton microscopy will allow direct investigation of global tissue alteration as well as specific immune cell localization during inflammatory tissue remodelling. Digital staining is an emerging concept in the field of computational microscopy but has not yet been implemented for immune cells based on label-free MPM images. Building on my previous expertise in label-free in vivo imaging via endomicroscopy, future implementations of multiphoton endomicroscopy would profit from tools for computational specificity, developed during this project.

Keywords: label free multiphoton microscopy,autofluorescence,machine learning,image classification,digital staining
Deliver sAfe and Social Housing (DASH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal,Serbia,Denmark,Germany
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 671600.0
EU funding (EUR): 671600.0
Participants: 18
Project status: SIGNED

Deliver sAfe and Social Housing - Housing is an important point of reference for citizens; the home is more than a physical framework for daily life: It is the social focal point of life through its contextual location and the relations it possesses. A proper and well-functioning home at an affordable price is of major importance for the individual. Good and healthy housing in attractive environments gives the residents and especially the children optimal opportunities to achieve a high standard of living and opportunities in life. Living in sub-standarHousing is an important point of reference for citizens; the home is more than a physical framework for daily life: It is the social focal point of life through its contextual location and the relations it possesses. A proper and well-functioning home at an affordable price is of major importance for the individual. Good and healthy housing in attractive environments gives the residents and especially the children optimal opportunities to achieve a high standard of living and opportunities in life. Living in sub-standard housing in difficult environments leads to inferior opportunities in life. Thus, housing policy has major impact on society and individuals. European societies are dynamic entities influenced by social, economic, demographic, and cultural influences. Recent decades have seen increasing social inequalities, more diverse demographic patterns, and changing preferences for big city life. Overall, the existing housing system and housing type are challenged; the need for large family homes is reduced when the proportion of families with children is significantly reduced. On the other hand, the need for smaller homes for singles and couples without children is increasing. In addition, there are growing regional differences in housing needs across Member States; while especially large cities are experiencing tremendous pressure on the housing market, the housing market in peripheral rural areas has stalled.

Keywords: affordable housing,
Liverpool Innovates for Everyone (LIFE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: Other destinations
Action type: Recognition Prize
Countries involved: United Kingdom
Call: The European Capital of Innovation Award (iCapital) (HORIZON-EIC-2025-PRIZE-2, 2025)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

Liverpool Innovates for Everyone (LIFE). LIFE is everything that Liverpool stands for in improving people’s Life chances and health outcomes through Innovation, and in building a Fairer future for Everyone. As both the Leader of Liverpool City Council Cllr. Liam Robinson and Metro Mayor of Liverpool City Region Combined Authority Steve Rotheram put it, innovation is in our DNA. Our leadership is bold – open to experimentation and taking risks. Acting as a test-bed for trialling new ways of doing things. European Capital of Culture in 2008 was a catalyst. It galvanised the city’s spirit, paving way to the pioneering pandemic responses and unprecedented delivery of Eurovision on behalf of Ukraine. That same leadership is committed to escalating the innovation ecosystem taking novel approaches to build it – from creating the entities that develop the spaces for innovation to happen, to providing the support needed to grow and scale businesses developing the solutions of tomorrow. This approach is supported by the first of its kind regional Innovation Board, with a laser focus on harnessing the power of innovation-led growth to create thriving communities. Innovation is not just being driven forward for the benefit of those living here, but to improve people’s lives around the globe. Once named one of the world’s most friendly cities, it’s no surprise that Liverpool is a collaborative place keen to share and learn from others around the world, particularly places with emerging innovation ecosystems. With a shared vision where no-one is left behind, a range of initiatives are helping to ensure that the sustainable and digital future being built in the region fosters a fairer, more cohesive and citizens rights-focused innovation community. From interventions to break down the barriers to participating in the innovation economy, to those around race equality and digital inclusion, leaders are committed to ensuring innovation is truly for everyone.
CHARTING THE TOKEN OF TIME: YAP/TAZ TRANSCRIPTIONAL REGULATORS AT THE ROOTS OF AGING (CHARTAGING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2811871.0
EU funding (EUR): 2811871.0
Participants: 1
Project status: SIGNED

A major challenge in aging research is to distinguish which age-related alterations play a driving role and their interconnections. Aging ultimately implies dysregulated transcription; yet, the identity of signaling cascades and transcription factors that control youthfulness and aging in adult tissues remains poorly understood. Aging also entails maladaptive changes in how cells communicate with each other and their surrounding extracellular matrix (ECM). Senolytics approaches have revealed the role of senescent cells as drivers of aging, leaving however unclear what cell types first become senescent in real tissue and why. Here, we aim to address and connect these fundamental unknowns into an integrative view of aging at an unprecedented spatial, temporal, molecular and mechanistic resolution. As preliminary results, we report that aging requires decreased activity of YAP/TAZ mechanosensors in stromal cells leading to unscheduled activation of cGAS/STING signaling, and that aging may be halted by restoring a youthful YAP/TAZ-cGAS/STING signaling balance. But why do we age then? Building on these findings, our hypothesis is that aging initiates from deterioration of our own “structural frames”: from changes in spatial/contextual signals that cells perceive from the ECM, to altered mechanotransduction and increased fragility of the nuclear envelope leading to cell senescence. These processes are reversible and understanding them may reveal new routes to halt aging. For this we will chart and functionally interrogate a multidimensional atlas of aging biology, delving into the logics of tissue physiology and its progressive degeneration over lifetime, also implementing novel methodologies. Our YAP/TAZ prism offers a unique vantage point to dissect causally relevant extracellular and intracellular mechanisms of youthfulness vs. aging, and opens to the exploration of aging remedies to restore youthful tissue ecosystems by restoring youthful YAP/TAZ activity.

Keywords: yap taz biology tissue ecosystems mechanics in physiology rejuvenation transcription factors and their regulatory networks