Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Brain Connectivity for Executive Control over Action in Ageing (ConnectExAct-Age)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

One hallmark of ageing is a motor functioning decline that represents a crucial impediment for healthy and active living. This multidisciplinary project combines detailed motor and neuropsychological assessments with multimodal neuroimaging techniques in an exceptionally large sample to pave the way for cognitive training interventions to improve motor functions in older adults. Its focus is on executive functions, i.e., high-level mental processes that control goal-directed, coordinated motor behaviour. These functions are likewise affected by ageing, but the contribution of executive decline to age-related motor impairment has not yet been unravelled. Executive functions are not a unitary capacity but span different facets. My project will reveal which aspects of executive functions are most relevant for movement control and its decline in older adults and thus constitute promising intervention targets. Structural and functional magnetic resonance imaging will reveal the neural basis of the links between executive and motor functions from a network perspective—an approach at the cutting edge of current neuroscience research. Profound re-organization of brain networks occurs during ageing, with aberrant coupling between usually distinct brain areas. This work will unravel how functional and structural network alterations are linked to motor and executive performance, allowing for a better understanding of age-related performance declines in both domains. The fellowship constitutes a perfect opportunity to develop my research and transferable skills. New skills as well as collaborations with my host group’s network will strengthen my profile as a researcher and place me in a strong position when competing for a permanent academic post. Combining my neuropsychological experience with Prof. Swinnen’s world-leading expertise in motor neuroscience will stimulate new ideas for ameliorating motor abilities in older adults to increase their healthy and active lifespan.

Keywords: executive functions,motor control,brain networks,functional,structural connectivity,resting state functional magnetic resonance imaging,diffusion weighted imaging,systems neuroscience
The aftermath of slavery in East Africa (ASEA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-11-01
End date: 2025-10-31
Duration (months): 72.0
Total project cost (EUR): 1921250.0
EU funding (EUR): 1921250.0
Participants: 1
Project status: SIGNED

Legacies of slavery tend to affect societies deeply, but in inland East Africa have remained little explored. This project aims [1] to establish what happened to the hundreds of thousands of slaves present in mainland East Africa in ca. 1900 and to their descendants over the twentieth century, [2] to explain why the aftermath of slavery is so little discussed in the written sources and historiography of the region, and [3] to trace the social and political legacies of slavery up to the present. It will combine historical and anthropological methods, and, besides post-slavery, addresses questions pertaining to public history, social mobility, marginality and inequality, gender, and understandings of freedom. It pursues them through a series of place-specific case-studies tracing different courses and outcomes within the region, and through comparative work, both between the case studies and with studies on the aftermath of slavery in West Africa, the Indian Ocean and the Americas. The project is ground-breaking through its long-term time frame, its wide-ranging combination of methods, and in questioning established assumptions, e.g. about the meaning of ‘freedom’ for ex-slaves. It is high-risk in the sense that the field researchers leading the case studies will need good knowledge of Swahili, good social contacts and the flexibility to identify and follow emerging leads wherever they take them. It is feasible because the proposed research program and conceptual frameworks can be adapted as the work develops, and given the obscurity of the regions, groups and questions involved, the resulting gains to knowledge will be major. It is high-gain because it will fill a gaping hole in current knowledge, and establish how people in East Africa coped with the toxic legacy of slavery, which often presents intractable problems, apparently with little disruption. The resulting comparisons will contribute to a better understanding of tensions in other post-slavery societies.

Keywords: historical anthropology,post slavery,histories of freedom
Mechanisms of Presynaptic Biogenesis and Dynamic Remodeling (SynapseBuild)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2496875.0
EU funding (EUR): 2496875.0
Participants: 1
Project status: SIGNED

Our ability to move, to process sensory information or to form, store and retrieve memories crucially depends on the function of neuronal synapses. Synapses comprise a presynaptic compartment harboring the machinery for neurotransmitter release and an associated postsynaptic compartment that processes the neurotransmitter signal. During decades of research we have acquired a wealth of knowledge regarding the mechanisms of neurotransmitter release and information processing in the postsynaptic compartment. In great contrast, we know surprisingly little about the pathways that direct the formation, transport, and assembly of the complex molecular machines that make up a functional presynapse. In particular, it is unclear where and how synaptic vesicle (SV) precursors are formed in the neuronal cell body, in which form they are transported along the axon, and which maturation steps occur to allow their assembly into functional units for neurotransmitter release. How cytoplasmically synthesized presynaptic active zone (AZ) proteins that organize SV release sites are transported and assembled is equally unclear. Here, we combine genome engineering in stem cell-derived neurons and genetically altered mice with proteomic, high-resolution imaging and systems biology approaches to identify the origin and composition of SV and AZ precursors, dissect the mechanisms of their axonal transport and integration into developing synapses and unravel the pathway that controls axonal transport and presynaptic assembly of newly made SV and AZ proteins to set synaptic weight. Our high risk/ high gain studies will yield groundbreaking insights into the mechanisms that mediate the formation, maintenance, and dynamic remodeling of the presynaptic compartment during development and thereby fill a crucial knowledge gap in neuroscience. Furthermore, they may pave the way for the future development of therapeutics to cure nerve injury or neurological disorders linked to synapse dysfunction.

Keywords: neurotransmission,synapse development,presynaptic compartment,synaptic vesicle,active zone,axonal,transport,biogenesis,human neurons,high resolution imaging
Holistic dEmand response Services for European residenTIAl communities (HESTIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Spain,Ireland,Italy,Italy,Italy,Austria,Spain,Italy,Serbia,Belgium,Belgium,France,France,France,France,Netherlands,Netherlands,Denmark,Denmark
Call: Consumer engagement and demand response (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 7514042.5
EU funding (EUR): 5995690.0
Participants: 20
Project status: SIGNED

HESTIA aims to provide a cost-effective solution for the next-generation DR services which will leverage the consumer engagement, energy and non-energy services, while dealing with both energy supply and demand side in a holistic manner. HESTIA intends to engage with residential consumers representing a still largely untapped sector, while enabling them to play an active role in flexibility sharing and grid balancing. HESTIA will enable residential DR services through: (i) exploitation of energy demand flexibility by engaging the consumers in demand-side management activities, and (ii) valorisation of energy efficiency in multi-carrier energy dispatching and optimal operation of building systems. HESTIA will exploit the consumer engagement as part of cooperative DR strategy at the community level, i.e. clusters of individual consumers and prosumers. To motivate the consumers to actively participate, HESTIA will leverage the financial, environmental and social drivers, while cross-fertilizing them to maximize the impact. HESTIA will involve the residents in the designing of the solutions through participatory co-design processes. HESTIA will create community engagement methodology and organisational tools with a high acceptance, that can be replicated and provide the corresponding tailored toolsets for a broader rollout. HESTIA will exploit the aggregated energy resource flexibility at the demand-side, in terms of cumulative energy consumption, distributed energy generation and storage, to better manage the disparity between energy demand, RES availability and grid requirements. User-personalized services will be delivered via a fully service-oriented, flexible ICT platform, underpinned by agent-based concepts, consumer digital twin and non-intrusive data analytics. This way, HESTIA will set the foundation for an open marketplace and a new grid reality, while steering consumer engagement according to the grid requirements and promoting RES and sustainable behaviour.

Keywords: cooperative demand response,participatory co design process,consumer digital twin,res and storage exploitation,open marketplace,local energy communities
Temporal structures of gender inequalities in Asian and Western welfare regimes (GenTime)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 1999739.0
EU funding (EUR): 1999739.0
Participants: 1
Project status: SUSPENDED

An important part of sociological understanding of how welfare regimes are shaped by culture and history derives from Esping-Andersen’s 'three worlds' account. But these worlds, and later developments in this field, including the extension and application of the framework to gender roles, derive exclusively from Western models. What will emerge as we seek to develop a global perspective on other models of welfare regimes and how they handle gender inequalities? We will answer this question, using newly available data deriving from beyond the conventional Anglophone and European theatres: from China, Japan, South Korea and Taiwan to explore patterns emerging from other cultural and social traditions. GenTime will be a study of gender inequality in patterns of time use across East Asian and Western societies. We will investigate the development trajectories and provision of unpaid work in different welfare regimes, and the systematic differences between men and women in the amount of time they spend on daily activities and their daily life schedules. It will examine time use as an important parameter of public policies. We will establish if East Asian regimes represent a distinct typology. The project will shed new light on the gender division of labour and social inequality across different regime types. Furthermore, we will examine how the use of modern technology in care provision and domestic labour may shape the trends in gender inequality. We will investigate the impacts on gender differences in leisure time and enjoyment in daily activities. High quality cross-national and historical comparative time diary data and household panel data will be analysed to study gender inequality 1) at the household level on how couples divide their roles in work and family; 2) at the societal level on the role of welfare regimes in shaping the trends in domestic division of labour; and 3) from a life course perspective on the impacts of time use on later family outcomes.

Keywords: welfare regimes,time use,east asia
One-step switchable fluorescent probe assay for direct virus detection. (1-SWITCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Sweden
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-05-01
End date: 2022-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Since March 2020, the world is facing the Covid-19 pandemic. As of September 2020, over 900 000 people have died of the disease, caused by the SARS-CoV-2 virus. The WHO recommendations in order to limit the spread of the virus are to “test, trace and isolate”. To be successful, this strategy requires fast and massive testing. Today, tests are performed using PCR, a resource-intensive process requiring extraction of the viral RNA before nucleic acid amplification. PCR tests are slow (several hours) and require an army of advanced laboratory equipment or automated diagnostic workflow setups for the various steps, and thus prevalent in centralized facilities testing samples in large batches. Consequently, the turn-around time for these tests has proven to be 24-48 hours globally. Here, we propose to develop a new Covid-19 test, 1-SWITCH, consisting of a single step switchable fluorescent probe assay. The 1-SWITCH technology will use low cost reagents, and therefore will be cheaper than current available Covid-19 tests. The sensitivity of the test will be superior to the one of antigen tests and comparable to the one of PCR tests. This 1-step, 1-tube method will detect the virus directly within minutes and eliminates the assay complexity, thus facilitating smoother workflows in laboratory diagnostics as well as point of care screening. This will consist of a major breakthrough in clinical diagnostics. Plans for bringing our research finding to a commercial innovation are presented.

Keywords: virus detection,sars cov 2,direct detection,high sensitivity,low cost
Triggered Investments in Grouping of buildings for Energy Renovation (TIGER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Italy,Italy,Italy,Italy,Italy
Call: Aggregation - Project Development Assistance (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 1087075.75
EU funding (EUR): 1087075.75
Participants: 9
Project status: SIGNED

The building sector is one of the major consumers of energy in Europe, responsible for 40% of energy consumption and 36% of CO2 emissions. Furthermore, Social Housing (SH) buildings show a critical state due to the lack of constant resources to upkeep and refurbish the existing stock and a long-term sound energy strategy (having to deal with emergencies). TIGER intends to improve the efficiency of SH by addressing the issues of the lack of funding and also contribute to tackling energy poverty which is a growing issue in Europe. Between 50 and 125M Europeans are unable to afford thermal comfort. The main aim of TIGER is the implementation of energy renovation interventions in SH buildings, expecting an investment over 16M€ through Energy Performance Contracting (EPC), with a simple payback period of 4 years. TIGER will engage over 1500 families living in 126 SH buildings, located in 58 municipalities in Abruzzo Region saving 8,7GWh/y of primary energy and reducing CO2 emissions of 1760tCO2/y, contributing to decarbonising the building stock. Further TIGER addresses energy poverty by improving energy efficiency, reducing energy consumptions and achieving adequate comfort levels. TIGER will develop an innovative model to be replicated and taken-up in different SH contexts. For the first time there will be a fully regional geographic approach- all 5 local SH operators will be engaged. Also the funding mechanism is innovative combining EPC with other financial instruments (ERDF, tax deductions, incentives, soft loan) in order to trigger investments by ESCOs. To properly deliver the setting-up of the investment scheme and the engagement and consensus of tenants, TIGER will appoint a PDA team including all technical and non-technical competencies and experiences (financial, technical and legal) and a capacity building programme for tenants will be set up to encourage vulnerable consumers to change their energy related behaviour.

Keywords: social housing,energy performance contracting,energy refurbishment,energy poverty,esco
Waste-Based Rapid Adhesive-free Production of Sports goods (Sport Infinity)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Materials for creative industries, including heritage
Action type: Innovation actions
Countries involved: Germany,Austria,Austria,Germany,Germany,Germany,Germany,Greece,France,United Kingdom,United Kingdom
Call: Materials solutions for use in the creative industry sector (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 10092806.0
EU funding (EUR): 7770947.0
Participants: 11
Project status: CLOSED

Sport Infinity aims to identify and develop innovative partly waste-based long-fibre reinforced composites enabling the automatic production of easily customisable plastic sports goods. The project will focus on the production of balls and shoes and will adopt a design-driven approach exploiting the automation potential of rotation moulding processes, which offer significant design freedom. The innovation potential of the moulding processes to be employed originates from their capacity of bonding together a multitude of different materials, while effecting external product shaping without using glue and/or other adhesives. The starting point is the development of composite materials superimposed in the form of layers in variable ways according to the targeted (custom) shape and the required properties. The insertion of decorative elements in the mould will enable design custom designs, along with 3D printing. An end-to-end collaborative design innovation will be adopted. The Sport Infinity consortium gathers expertise across the value chain from design to material development, production, marketing and distribution and across multiple disciplines industrial design, material science, recycling and industrial processes. The new flexible automatic production, can set a paradigm of competitive production Made in Europe favouring ranging from modular factories to in-store production cells.

Keywords: long fibre reinforced composites,waste based materials,footwear,sports,rotational molding
Promoting the Implementation of Safe by Design (PROSAFE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Ensuring the safe and sustainable development and application of nanotechnologies
Action type: Coordination and support actions
Countries involved: Germany,Italy,Italy,Italy,Belgium,Romania,Switzerland,France,Netherlands,Netherlands,Portugal,United Kingdom
Call: Coordination of EU and international efforts in safety of nanotechnology (H2020-NMP-CSA-2014, 2014)
Start date: 2015-02-01
End date: 2017-04-30
Duration (months): 27.0
Total project cost (EUR): 3095073.47
EU funding (EUR): 2512612.0
Participants: 14
Project status: CLOSED

The CSA links different initiatives and facilitates the integration of results from these initiatives, so that a maximum use of these results can benefit the regulatory process. The CSA is designed to facilitate this process and show European leadership on chemical safety, including nano’s. The aim of this activity is to coordinate and support for risk assessment, management and governance by streamlining data acquisition, collection and management on regulatory orientated toxicology testing of nanomaterials, exposure monitoring, LCA, and disposal and treatment of waste nanomaterials. A number of topics were not included in NANoREG, as they fell outside the scope of that call. The principles enshrined in NANoREG will through PROSAFE be transferred to as many other member states and non-EU states as possible. Nano-safety can be considered to improve significantly when Safe by Design is internationally accepted to guarantee safety. But it lacks agreed definitions, guarantees, and therefore confidence for acceptance. PROSAFE will facilitate and promote the acceptance of Safe by Design within the EU-COM, its Member and Associated states. Consideration is given to regulatory developments including challenges raised by the convergence between nano and biotechnologies. To prepare for the future, after decades of playing EHS catch-up on innovations that became major environmental hazards like lead, asbestos, PCB’s, a shift is needed towards a proactive approach of demonstrating safety and sustainability in pre-commercial innovation. Priorities are: •Move from generalized discussions to case specific differences •Improve characterization of nanomaterials and require reporting on their use •Increase funding for research on ecotoxicology and environmental fate and behaviour •Use value chains assessments when considering environmental impacts •Commit to environmentally sustainable and socially robust innovation.

Keywords: risk assessment,risk management,toxicity,nano safety,regulatory,green engineering,safe by design