Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Early warning of future rapid Arctic sea ice loss (ArcticWATCH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1456652.5
EU funding (EUR): 1456652.5
Participants: 1
Project status: SIGNED

The Arctic is currently transitioning toward a new climatic state that will be characterized by seasonally sea-ice-free conditions almost every year from the 2050s, with widespread ecological, climatic, and societal consequences. There is growing evidence that the future summer sea ice retreat will not occur at a constant rate. Indeed, climate model simulations are suggestive of pronounced sub-decadal fluctuations on top of the long-term trend, leading to periods of relative stability followed by abrupt sea ice decline in hardly 3-5 years. A lot remains to be understood regarding the precursors, mechanisms, predictability, and impacts of these rapid events. In particular, it is unclear how close we might be to the next one. The overall objective of this project, ArcticWATCH, is to build an integrated early warning system that alerts on the possibility of rapid Arctic sea ice loss for the following summer up to five years. This system will provide annually updated assessments and will synthesize multiple lines of evidence harvested from various data sources (pre-existing and generated during the project), including climate model projections, initialized climate model and machine-learning-based predictions, satellite observations, and climate reconstructions. By introducing innovative targeted numerical experiments, ArcticWATCH will also identify the new pathways of sea ice predictability in a warmer world and will thereby provide evidence-based guidance regarding the design of the Arctic observing system for the next 30 years. Finally, ArcticWATCH will make a leap forward in depicting environmental impacts during and after rapid sea ice loss events, from short (Arctic heatwaves and precipitation extremes) to long (interactions with the Arctic and North Atlantic oceanic circulation) timescales. The hypothesis that, after a decade of relatively stable conditions, Arctic sea ice is poised to an abrupt decline before 2030, will be paid utmost attention.

Keywords: arctic,sea ice,rapid climate changes,seasonal to interannual prediction
BodyElectric: Unlocking the Potential of Electrotactile Haptics (BodyElectric)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-06-01
End date: 2031-05-31
Duration (months): 60.0
Total project cost (EUR): 2499820.0
EU funding (EUR): 2499820.0
Participants: 1
Project status: SIGNED

BodyElectric will develop a new form of haptics using electrotactile stimulation to transform our ability to incorporate tactile feedback into everyday products, to create richer interactive experiences, with lower environmental cost. Tactile haptics is a key feature of many devices, from phones to in-car user interfaces, significantly improving usability and user experience. However, touch is limited to vibration. Vibration actuators are bulky, low bandwidth, use non-sustainable materials, and only evoke a very limited set of sensations. This means we cannot make full use of our powerful touch sense and limits the applications of haptics. Electrotactile stimulation is the only effective solution for adding tactile displays to flexible devices with different geometries, at a low cost, power consumption and complexity. However, there are 4 key challenges that must be addressed: . Perception – Knowledge of how electrical stimulation is perceived is limited; we have no clear basis on which to design comfortable, safe and effective stimuli . Electrode Design – There are no sustainable electrodes, printable on to the surfaces of everyday devices to deliver stimulation . Impedance Changes - Skin impedance and sensitivity vary over the body and over time; the same level of stimulation could become painful (or imperceptible) if the user sweats or moves their body . Interaction Design - Little is known about how to design effectively using electrotactile haptics and there are no tools to help Our vision to solve these problems requires ground-breaking work at the intersection of HCI, psychology and biomedical engineering to: 1 Conduct fundamental studies in the perception of electrotactile stimulation 2 Engineer sustainable electrode hardware and closed-loop impedance sensing for personalized feedback 3 Create and validate new electrotactile and multimodal interactions 4 Evaluate and demonstrate the practical effectiveness of electrotactile haptics in real world use

Keywords: haptics,tactile,electrotactile,tactons
SPIKEPro Hop-On: Spiking Photonic-Electronic IC for Quick and Efficient Processing (SPIKEPro Hop-On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Netherlands,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 659740.0
EU funding (EUR): 659740.0
Participants: 2
Project status: CLOSED

Rapid advances in artificial intelligence have led to powerful models and algorithms which drive conventional computing hardware to its limits regarding energy efficiency and speed. The EIC SPIKEPro project develops a novel neuromorphic chip technology, enabling spiking neural networks (SNN) to process data in more efficient ways. SPIKEPro proposes a science-towards-technology breakthrough by combining low-energy electrical and photonic neurons with memristive weighting elements into a joint spiking neural network on chip. This hop-on project significantly accelerates and facilitates SPIKEPro by providing solutions for accurate control, interconnection and tuning of the analog SNN, not planned in the original project. The hop-on partner INL will develop specifically tailored Low-Power Analog Mixed-Signal CMOS control circuits and connect those to the analog SNN through a high-density chiplet interconnection process at wafer scale (200-mm). This will enable automated control, training and test of the new SNN technology and at the same time validate neuromorphic technology up-scaling and elevate the TRL. Furthermore, novel integrated circuits will be designed to tune the performance of electrical spiking nodes, which is exploited as additional means for efficient training. As a consequence, the SPIKEPro demonstrators can use the hop-on control circuits and benefit from fully integrated automatic control algorithms and hardware-level feedback loops. This will maximize the impact of SPIKEPro’s scientific activities and provide a concrete route towards prototype level technology. This project will be a timely opportunity in creating a new semiconductor chiplet packaging platform for neuromorphic computing in a PT-North European partnership, leveraging recent investments of PT in the Chips Act. It will reinforce the country and the region’s national semiconductor ecosystem identified as of strategic economic importance, specifically in the advanced packaging area.

Keywords: semiconductors components,ic,optoelectronics,photonic integrated circuits,neuromorphic hardware,spiking neural network,brain inspired computing
Exploring a click-to-release approach to uncage FAP-theranostics, based on TCO-radiotracers (C2RTheranostics)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Radioligand therapy has recently received renewed attention as promising treatment option to improve cancer patient outcome. Compared to conventional cancer treatments, this strategy involves a more specific targeting of therapeutic radionuclides to the tumor, which aims to increase treatment efficacy. Despite recent progress, currently available treatments show insufficient tumor killing and normal tissue toxicity, and we hypothesize that a pretargeted click-to-release (C2R) strategy can bridge this gap. Within this strategy, we propose to explore Fibroblast Activation Protein (FAP) inhibitors as tumor targeting vectors, to deliver a therapeutic radionuclide fragment intracellularly using cell permeable, cleavable transcyclooctene (dcTCO) constructs and compare it with conventional dTCOs. To reinsure intracelular release, after C2R, we designed new structures containing an RGD peptide (with integrin αvβ3 binding specificity). Our molecular constructs also aim to prevent FAP efflux, by using a guanidinium and nicotinoyl residualizing groups. This project will evaluate the reactivity, in vitro stability, logD and radiochemical yield of the new molecules, and the C2R efficiency of the dcTCOs. A FAP inhibitor (dimer) will be weaponized with a tetrazine handle to be the targeting vector and biorthogonal pair of these new constructs, and it's affinity and selectivity will be evaluated in vitro, against other proteases. The dcTCOs and dTCOs with better reaction kinetics and C2R efficiency (dcTCOs) will be selected for the development of 18F- and 125I-radiolabeled probes. The celular uptake and internalization will be evaluated on tumor cells (FAP positive cells, integrin αvβ3 positive cells, both FAP and αvβ3 positive). This project is a innovative strategy to improve the radiation dose delivered to the tumor and improving treatment outcome, while reducing radiotoxicity and achieving better treatment tolerability.

Keywords: radiotracers,biorthogonal chemistry,click to release,theranostics
Implementation and validation of a closed-loop neural interface to entrain brain rhythms and reduce motor symptoms in Parkinson's Disease (RhythMods)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Neurological diseases, such as Parkinson’s Disease (PD), are the leading cause of disability in the world. The role of brain rhythms has not been completely understood but evidence suggest that specific motor disorders may be linked to abnormal brain oscillations. Researching ways to modulate specific cortical motor rhythms could lead to discovering more effective approaches to treat patients with neurological disorders affecting their motor condition. However, our current understanding tools are insufficient to access and interact with this kind of neural activity. Non-invasive neuromodulation protocols such as transcutaneous Spinal Cord Stimulation (tSCS) are raising interest in recent years to induce changes in the Central Nervous System (CNS) that can lead to functional improvement, while the side effects and applicability limitations of invasive procedures are overcome. Better understanding the interaction between neuromodulation protocols and brain rhythms is crucial for the development of interventions targeting pathological circuits which can favour plastic changes and the restoration of impaired motor functions. In RhytMods, I will develop a non-invasive neuromodulation platform to apply closed-loop stimulation protocols synchronized with brain oscillations decoded from the periphery with muscle recordings (high-density electromyography, HD-EMG). The platform will allow to explore the modulatory effects of brain-oscillations-dependent stimulation of the CNS to treat motor symptoms and its potential to entrain and disrupt neural oscillations linked to motor recovery in patients with PD. This research has the potential to transform our understanding of neurological disorders with pathological brain oscillations and to develop new minimally invasive and cost-effective technologies to treat the motor symptoms in neural disorders.

Keywords: neural engineering,neurorehabilitation,neuroscience,parkinson s disease,neuromodulation,emg
Chiral Nanoplatelets Assemblies for Optoelectronic and Spintronic Devices (CHINOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

Chirality is an inherent property in nature characterized by asymmetry and distinctiveness. Incorporating chirality into semiconductors has provided unique optical and electronic characteristics that differ from those of achiral semiconductors, leading to innovative applications in optical communication and quantum computation. This project aims to comprehensively explore the synthesis of a emerging chiral semiconducting nanomaterial, chiral semiconducting nanoplatelet assemblies, and examine their potential in optoelectronic and spintronic devices. The project is separated to three primary objectives: 1. Develop synthesis methods for chiral nanoplatelet assemblies. 2) Investigate and enhance the chiroptical properties of these assemblies. 3) Integrate the chiral assemblies into photodetectors, LEDs, and spin polarizers. This research will contribute to the advancement of next-generation optical communication and quantum information technologies.

Keywords: chirality,semiconductors,nanoplatelets,assembly
Clean bioenergy for industry - Novel fuel flexible highly efficient and close-to-zero emission combined biomass gasification and combustion technology for industrial applications (CBE4I)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Austria,Sweden,Spain,Netherlands,Germany,Italy
Call: Efficient and low-emission technologies for industrial use of combustion and gasification systems from low-value biogenic residues and wastes (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 4974688.75
EU funding (EUR): 4974688.75
Participants: 9
Project status: SIGNED

CBE4I aims at the development of a novel, fuel-flexible biomass updraft gasification based technology for a highly energy efficient, almost zero emission and zero waste process heat supply for flexible implementation at industrial settings satisfying the specific demands of industry. Low-value biomass residues which are available in large quantities shall be applied. CBE4I shall provide either (i) heat at different temperature levels which can be applied for indirectly heated processes via product gas combustion in an almost zero-emission gas burner with integrated three-way catalyst flexibly coupled with different boiler types (hot water, thermal oil, steam) or (ii) process heat and a clean product gas via product gas extraction with integrated thermal and catalytic tar reforming for utilisation in gas burners for direct heating. A novel flue gas condensation concept with directly coupled heat pump shall boost efficiency up to 120% (related to the NCV of the fuel). A newly developed condensate treatment shall allow for a direct discharge into sewers and regarding ash utilisation a new concept for application of biomass ashes in fertilizer production shall be developed. Moreover, CBE4I shall include the necessary fuel pre-treatment technologies and fuel logistics suitable for industrial sites. The latter comprise space saving on-site fuel logistics and on-line fuel quality assessment based on a new intelligent crane system. The methodology applied to reach these goals relies on technology development tasks (based on process simulations, CFD aided design of the single units, test plant construction, performance and evaluation of test runs), a technology assessment part covering risk assessments, LCAs, techno-economic, environmental and overall impact assessments as well as targeted dissemination activities. A market study shall investigate and define the framework conditions and application potentials of the CBE4I technology in different industrial sectors.

Keywords: updraft gasification thermal tar reforming catalytic tar reforming three way catalyst flue gas condensation heat pump ash utilisation fertiliser fuel logistics zero emission closed cycles
A holistic approach to bridge the gap between microsecond computer simulations and millisecond biological events (MilliInMicro)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2134529.0
EU funding (EUR): 2134529.0
Participants: 1
Project status: SIGNED

Complete understanding of how complex biological objects operate and fulfill their cellular role requires at its core a detailed picture of the millisecond (ms) conformational transitions between functional states. Computational investigation of such ms–events is thwarted by our difficulty—and often impossibility—to identify and sample efficiently the relevant degrees of freedom at play, as well as the current limitation of all-atom molecular dynamics to the microsecond (μs) timescale on common computer architectures. Guided by concrete biological questions that experiment alone has hitherto proven unable to address, we propose a holistic approach to bridge affordable μs–computer simulations and ms–biological processes without the aid of a special-purpose supercomputer. To meet this grand theoretical challenge, we will associate two powerful developments to make the quantum leap, and open a breadth of applications, scaling up to very large biological objects, so far inaccessible to μs–timescale computer simulations. First, we will determine the reaction coordinate in an unprecedented combination of data- driven discovery of collective variables and advanced algorithms to find the minimum free-energy pathway that connects the end states of the conformational transition. Second, we will accelerate sampling along this pathway by associating ergodic schemes to a novel approach that maps complex free-energy landscapes significantly faster than its competitors. We will apply this methodology to a V1Vo–ATPase, a complete ATP–driven biological motor that converts over the ms–timescale the chemical energy of ATP hydrolysis into mechanical work, with minimalist dissipation. Beyond illuminating the allosteric pathways that underlie the conformational transition, atomic-level description of the rotary-catalysis milestones will shed new light on the effects of pathological mutations altering ATP activity, while helping engineer artificial cells with accelerated ATP turnover.

Keywords: allosteric transitions rare events numerical simulations molecular dynamics free energy path search kinetic modeling biological motors atpase
PROcessing MEtaphors: Neurochronometry, Acquisition and DEcay (PROMENADE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1854188.0
EU funding (EUR): 1854188.0
Participants: 1
Project status: SIGNED

As the master figure of speech, metaphor is a powerful communicative tool that might nevertheless come with costs for our processing system. Research in different fields has highlighted that a full-fledged metaphor comprehension capacity is a late achievement in development, it may decay as a consequence of several pathological conditions, and it evokes distinctive electrical activity in our brain compared to literal equivalents. However, we still miss a comprehensive framework able to account for all these empirical findings in a unitary fashion, and this despite a vast number of linguistic and cognitive accounts of metaphor. This project will ground on theoretical insights from the pragmatics of language to sketch a novel and comprehensive model of metaphor understanding able to account for neural, developmental, and clinical findings. The leading hypothesis is that metaphor comprehension is an inferential process that involves first adjusting the lexical concepts, and then deriving the implicated -non-literal- meaning. The model also takes into account the multiplicity of metaphor types, which might in turn engage visual images and sensory-motor processes, in line with recent multimodal accounts of lexical and semantic processing. The model will be tested and refined through a series of behavioral and electrophysiological studies employing innovative experimental paradigms and involving neurotypical adults, children, and individuals with psychiatric and neurodegenerative diseases. This multidisciplinary approach will lead to a significant breakthrough in our understanding of metaphor as the pinnacle of human verbal creativity, in addition to disclosing important aspects for research on language processing, development and decay.

Keywords: metaphor experimental pragmatics