Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative tools to examine the development of antisocial behaviour from early childhood to adolescence: Genetically informative designs and propensity score matching (INNOVANTI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-15
End date: 2015-10-14
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Antisocial behaviour is a substantial problem in Europe: detrimental to victims, the youth, families and society as a whole. Among promising research avenues are the use of genetically informative longitudinal studies, as well as research designs aimed to determine which predictors of antisocial behaviour are causative. Using such innovative designs, my primary purpose is to provide a better understanding of the development of antisocial behaviour from early childhood to adolescence and its predictors, which will help to identify important targets for intervention and will provide an indication of when best to intervene. I will use the Twins Early Development Study (TEDS), a unique data set of 10000 pairs of twins born between 1994 and 1996 and followed from 2 to 16 years. The present project comprises 3 complementary objectives: (1) identify childhood disorder symptoms uniquely predicting adolescent delinquency and identify the genetic and environmental contribution in the prediction; (2) verify whether harsh parental discipline and peer victimization play a causal role in the prediction of antisocial behaviour; (3) determine at which age and for which populations (e.g. disadvantaged populations) heritable or environmental components play a greater role in antisocial behaviour. I will use advanced statistical modelling, namely by combining twin modelling with propensity score matching. The present project will generate new knowledge with both innovative techniques and a data set of unique quality. As such, the project is both innovative and timely. So far, I have received interdisciplinary training in a world leading research team specialising in antisocial behaviour, which has resulted in high impact publications. With the proposed fellowship, I will benefit from outstanding specialised training and mentoring, which will be crucial to establish myself as an independent researcher and contribute to the excellence of the European Research Area.

Keywords: s204 clinical and experimental psychology
MAPK signalling network to adapt leaf growth to drought conditions (MAPKINDROUGHT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Drought stress signal is sensed either directly, e.g. in root cells, or indirectly through systemic spread of the signal by hormones and other messenger molecules, and the information is processed through complex signaling pathways to elicit growth adaptation responses. MAPK signalling pathways, a fundamental circuitry of stress signalling, constitute a hierarchical three-tiers system of protein kinases: MEKK, MEK and the MAPK, which phosphorylate specific substrate proteins, thereby changing cellular behavior. Both my lab in Szeged and the Bogre lab at Royal Holloway performed an- gene activation screening for stress-regulating processes, and found MKK7 and MKK9 and two downstream MAPKs, MPK3 and MPK6 to lead to stress adaptation and to regulate plant growth. The overall aim of the proposed research is to identify the targets of the MKK7/MKK9 – MPK3/MPK6 drought-responsive MAPK signaling pathway, and link these to the growth adaptation of plants under drought stress conditions. To do this we will perform: (i) unbiased phosphoproteomics screen for MAPK targets using mimicked drought conditions with mannitol treatment and the inducible MKK7/MKK9 lines, (ii) computational predictions of MAPK substrates involved in drought responses, (iii) targeted approaches to test MAPK phosphorylation of key regulators in plant growth regulation, the RBR transcriptional repressor complex. We aim to map the phosphorylation sites on RBR and DPB and on at least three newly identified MAPK substrates, mutate these sites and transform the mutant genes back to Arabidopsis wild type plants and into lines with altered MKK7/9 signaling pathway. Growth phenotyping of these lines under control and drought stress conditions should link this MAPK pathway to drought adaptation. In the course of the project I will obtain training in interdisciplinary research; proteomics, computational biology, and gain transferable skills to become an all rounded scientist.

Keywords: plant growth and development,drought tolerance,stress response,mapk signalling,phosphoproteomics
Studies on jasmonate modulation of distal stem cell activity in Arabidopsis root. (JASMONATESTEMCELL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 177000.0
EU funding (EUR): 177000.0
Participants: 1
Project status: CLOSED

Postembryonic root growth of higher plants is maintained by the root meristem (Dolan et al., 1993, Development, 119: 71-84; Weigel and Jürgens, 2002, Nature, 415: 751-754). Our previous studies have highlighted the importance of MYC2-mediated jasmonate signalling in regulating root meristem size by repressing auxin signalling (Chen et al., 2011, Plant Cell, 23: 3335-3352). At the cellular level, we showed jasmonate is capable in disturbing the cellular patterning of the stem cell niche by promoting cell division in quiescent center (QC) and distal stem cell (DSC) differentiation. Maintenance of stem cell activity is crucial for the persistence of postembryonic root growth and many questions on how roots preserve their stem cell niche remain unanswered. Furthermore, nothing is known on how jasmonate signalling interferes with stem cell activity. In this project, we will take profit from the accessibility of the DSC in the Arabidopsis root and will focus our efforts on jasmonate signalling in regulating DSC activity during postembryonic root growth. By DSC specific expression profiling in combination with a comparative analysis of other root specific transcriptome analyses (Birnbaum et al., 2003, Science, 302: 1956-1960; Brady et al., 2007, Science 318: 801-806), we will be able to identify targeted genes involved in jasmonate-regulated DSC differentiation. Genetics tools, cell biology and biochemical techniques will be used to study the mechanisms underlying jasmonate-regulated DSC maintenance. The project will extend our view on how plants retain growth plasticity and on how plants translate stress cues into growth responses. The aim of the fellowship is to add to my knowledge and skills in order to broaden my career prospects in line with the needs of the future knowledge-based agriculture of Europe and the world.

Keywords: lif: plant biology,plant hormone,jasmonate,auxin,root,stem cell maintenance
MKlp2 - a mitotic kinesin and a prime target for cancer therapy (MKLP2-MITOSIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-11-01
End date: 2015-10-31
Duration (months): 24.0
Total project cost (EUR): 261384.6
EU funding (EUR): 261384.6
Participants: 1
Project status: CLOSED

Mklp2, a mitotic kinesin and a prime target for cancer therapy MKlp2 belongs to kinesin 6 family and was first identified as an effector protein of small G protein Rab6A, involving in the retrograde transport between Golgi and ER. While its function in Golgi-ER trafficking awaits further study, MKlp2 has been shown to play crucial role in mitosis. It is essential to relocate chromosomal passenger protein Aurora B and the mitotic regulator Plk1 to the central spindle during anaphase. Depletion of MKlp2 results in failure of cytokinesis. In addition, MKlp2 is overexpressed in several human tumor cells and inhibition of MKlp2 reduces the tumor cell growth. Those properties make MKlp2 a prime target for developing anti cancer drugs. MKlp2 has been shown to interact directly to Plk1 and Mad2, the mitotic checkpoint complex protein. However, the mechanism of MKlp2 motor protein and how those interactions may regulate its function is unknown. In addition, MKlp2 possess unique sequences in its motor domain compared to other kinesins which may render its mechanism of nucleotide/microtubule binding. To understand how MKlp2 functions and how it’s regulated during mitosis, we propose a thorough functional and structural characterization of this interesting motor protein. Aim1. Functional and structural characterization of the motor domain of MKlp2, the kinesin involves in cytokinesis and a potential target for anti-cancer drugs Aim2. To study in detail the interaction between MKlp2 and Plk1, its regulation of the function of MKlp2, and to determine the structure of the complex Aim3. To characterize the interaction between MKlp2 tail domain and Mad2, the structure of the complex, and the role of the interaction in cytokinesis Our results from this multidisciplinary proposal will provide valuable information on the mechanism of MKlp2, further our understanding on kinesin motors, and allow development of anti-cancer drugs.

Keywords: l101 molecular biology and interactions,l107 structural biology,l302 cell biology and molecular transport mechanisms,l303 cell cycle and division,l406 cancer and its biological basis
Textile Terminology of Hittite Anatolia (TEXTHA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-02
End date: 2015-12-08
Duration (months): 24.0
Total project cost (EUR): 230809.8
EU funding (EUR): 230809.8
Participants: 1
Project status: CLOSED

This research project will provide an accurate and updated analysis of the Hittite textile terminology. This will be achieved through a precise examination of the preserved epigraphic sources. In order to pursue this analysis, the research project needs as a necessary first step the creation of a complete corpus of all epigraphic sources of the “Hittite textiles”, the first of its kind. The methodological approach will be based on a meticulous lexical and etymological investigation on verbal - noun paradigms referring to textiles in the Hittite world and professional titles. The primary objective is to create a comprehensive and useful dictionary of textile terminology of Hittite Anatolia. I will integrate my own academic background skills in Hittite language and philology with my host institution’s expertise in the fields of experimental archaeology of ancient textile remains and tools. Thus, I will combine the information provided by specialists of the Centre for Textile Research with the data which I will collect by analysing the Hittite textual documentation; not only administrative and economic texts, but also all those Hittite written sources that potentially describe the palace management of textile production, the accounts of weaving workshops (including terms for crafting and tools), the luxury goods as finished products (not only cloth, but also clothes and furnishings) and the textile items used in symbolic contexts. The comparative methodological approach is justified by the fact that ancient textiles rarely survive, not only in Anatolia, but also all over the ancient Near East and Mediterranean area, with the notable exception of Egypt. Fortunately the Scandinavian area provides many Bronze Age finds that have been already accurately analysed by Danish and Swedish specialists in recent years. Their technological competence will be very useful to me in order to better define textile terms attested in the written documentation.

Keywords: soc textile terminology of hittite anatolia lexical-etymological investigation experimental archaeology multidisciplinary project
Establishing safe, positive, inclusive school environments: The three-tiered prevention paradigm (ESPISE-3P)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Cyprus
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-09-02
End date: 2016-09-01
Duration (months): 36.0
Total project cost (EUR): 254690.7
EU funding (EUR): 254690.7
Participants: 1
Project status: CLOSED

Educating diverse students in today’s schools is an ever-increasing challenge. General education teachers in Cyprus face an increasingly diverse student body to teach. When students exhibit chronic reading and behavioural problems, the tendency is to react by initiating referrals for special education and applying stringent measures for disruptive behaviours. Soon enough, students enter a snowballing path of academic disengagement, low academic achievement, and thus they face school failure, and early school leaving. Recently, emphasis has shifted towards creating schools as positive learning communities by promoting a constellation of evidence-based interventions and processes for achieving an inclusive social culture for all children. This project aims at developing a systems-change paradigm to promote positive, safe and inclusive school environments and enhance collaborative partnerships with local communities. The proposed paradigm will consist of a three-tiered prevention school model, which will include primary instruction to avert the onset of behavioural problems, secondary prevention strategies that address small groups of students who need additional support to successfully acquire new reading and behavioural skills, and tertiary prevention that focuses on more intense explicit instruction for students who despite previous instruction efforts experience chronic behavioural and reading problems. The interventions will be strengths-based, culturally competent, family-focused, and easily maintained once project support will be removed. For this purpose, the fellow will receive rigorous comprehensive training in research-established sustainable three-tiered preventative school frameworks, develop a preventative paradigm for elementary schools of Cyprus and pilot test it there. Expected outcomes will be: the cultural adaptation of the three-tiered prevention school model with a plethora of dissemination products and outreach activities.

Keywords: applied behaviour analysis,inclusive education,positive behaviour interventions and supports,school violence prevention
Euro-Mediterranean Urban Voids Ecology (EMUVE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-07-09
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The research project focus on the existing voids produced by current shrinking cities at the Euro-Mediterranean coastline. These cities, developed in the last 50 years as the main touristic destination of Europe, are now in many cases transformed in empty landscapes stopped by the present economic crisis. The voids of these abandoned territories are not more anomalous interferences within the urban fabric, but unlimited spaces disfiguring the littoral. Voids not only understood as the spaces that were not developed, but also as the thousands of square meters of Real Estate speculative developments that remained half-built, converted in future ruins. These terrain vagues, where everything is possible, could be reactivated with new strategies of urban experimentation, interpreted as complex systems of social, environmental, economical, topological, and symbolical relationships. This work intends to develop a comparative research on several Case Studies along the Euro Mediterranean littoral. A Case Study is the cities of the Spanish Mediterranean coastline. Large areas of real estate developments aimed for sun and beach tourism have been abandoned. Many industrial areas built during the Industrial Revolution at the Spanish littoral are now converted in ruined post‐industrial voids with heritage values, surrounded by empty Real Estate developments. The recycling of these Post‐industrial spaces could contribute as future cultural and economic magnets to the reactivation of these degraded areas into productive and ecological landscapes. New recovering strategies should be found for the post-economic crisis landscape at the Mediterranean coastline, in order to offer new alternatives of development for the local population, in close interaction with the environment. The Landscape and the Ecology Urbanism could offer useful instruments to understand and explore the adequate intervention systems and economic reactivation strategies for these abandoned areas.

Keywords: landscape,architecture,environment,ecology,mediterranean,coastline,urban,void,sustainability,recycling,resilience,scenario design,post-industrial,sustainable development,natural resource
NET-GENESIS: Network Micro-Dynamics in Emerging Technologies (NET-GENESIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-03-13
End date: 2016-03-12
Duration (months): 24.0
Total project cost (EUR): 196682.1
EU funding (EUR): 196682.1
Participants: 1
Project status: CLOSED

The NET-GENESIS project aims to investigate how networks form, evolve and are configured when a new technology emerges. These networks include a number of interlinked actors (e.g. individuals, organisations, institutions) extending across multiple domains in which the rewards systems, incentives and power structures can differ markedly (open science vs. market-based). The architecture of the relationships among these actors may exert a significant influence in shaping technological change in certain directions rather than others, which in turn may have the potential to provide more socially optimal or desirable technological options. In this regard, a number of examples can be identified to highlight the importance of these networks for emerging technologies. For instance, networks can represent channels through which entrepreneurs and firms access to the financial resources (e.g. venture capitals) required pursuing R&D activities. In addition, the open-innovation framework has highlighted how networks are critical conduits for the exchange of knowledge, ideas, and resources among the different actors involved in the innovation process. Finally, networks extend also across science and technology domains thus stimulating scientific discoveries and supporting the development of novel technological applications. However, while the literature contributing to our understanding on how network variables affect actors’ performance and behaviour is quite large, the genesis and dynamics of the networks surrounding emerging technologies remains a relatively unexplored area of research. The proposed project is a cutting-edge project that aims to contribute to filling this gap by conducting a comparative study (involving 6 case-studies) on the network micro-dynamics of emerging technologies across three industries, i.e. pharmaceuticals, biotechnology, and nanotechnology. To this end, a mixed qualitative-quantitative approach involving several levels of analysis will be adopted.

Keywords: network micro-dynamics,power,emerging technologies,multiple-case-study
Inhibition and neuromodulation in oscillation and synchrony (NEURODYNAMICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2016-05-31
Duration (months): 24.0
Total project cost (EUR): 275138.8
EU funding (EUR): 275138.8
Participants: 1
Project status: CLOSED

Cognition depend on the cooperation and communication between functionally connected brain areas. Oscillation and synchrony appear to be crucial for the engagement and disengagement of functional neural circuits. Many studies suggest inhibitory neurons in the brain dictates how and when the information is relayed between neuronal ensembles. The valence of these excitation-inhibition interactions are further regulated by neuromodulators such as dopamine (DA) and the diversity of differential expression of different types of neuromodulator receptors. Here, we propose to: 1) invent novel solutions to combine optical stimulation and neurophysiological recordings into one integrated probe drive for implantation in rodents; 2) provide causal evidence that prefrontal (mPFC) parvalbumin-containing (PV) inhibitory neurons are responsible for coordinating prefrontal-hippocampal (mPFC-HPC) oscillation and synchrony and; 3) examine the role of dopamine action on mPFC-HPC interactions and elucidate the specific role of DA receptor subtype-1 in PV neurons in coordinating DA-mediated effects. The goals of the proposed project will be achieved by using a fully multidisciplinary approach combining state-of-the-art molecular, neurophysiological, genetic and behavioural techniques. Particularly, innovative use of optogenetic tools will be used to control neural activity and RNA interference will be used to knock-down dopamine receptor expression by the use of viral vectors and transgenic animals. We expect to be able to provide novel solutions to simultaneously apply optical stimulation and neurophysiological recordings in multiple brain areas and reveal the importance of inhibition and neuromodulation in the control of oscillation and synchrony. The outcome of the proposed work will provide us with innovative tools for brain investigation, novel insights regarding brain function, as well as providing tools for the diagnosis, monitoring and understanding of brain dysfunction.

Keywords: l501 neuroanatomy and neurophysiology,l502 molecular and cellular neuroscience,l508 behavioral neuroscience,l509 systems neuroscience,l512 psychiatric disorders,l507 cognition