Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
YouthDecide 2040: Visions of Democracy with and for Future Generations (YouthDecide 2040)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Austria,Slovakia,Belgium,Spain,France,Germany,Poland,Italy
Call: Future scenarios and young visions for European democracy 2040 (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3939826.75
EU funding (EUR): 3939826.75
Participants: 11
Project status: SIGNED

Democracies in Europe have demonstrated resilience and modernisation in the face of various social and technological challenges. Democracy in the age of the Anthropocene will necessitate radical shifts in values, power relations and modes of governance, while also being built on the present, in all its diversity, paradox and insufficiency. Innovating to meet these challenges will require re-imagining how people living in democracies become equipped and supported to co-create resilient, democratic futures in Europe and beyond. Clear visions are needed to build strategies that allow for rethinking and redesigning spaces, institutions, instruments and ways to represent and include people in democratic governance. YouthDecide 2040 aims to support European Union democracy to rise to these challenges through evidence-based historical and contemporary knowledge, strategic foresight, and robust deliberation. Specifically, YouthDecide 2040 has the main objective to: co-create with European youth – and older generations, political and institutional actors, and organised civil society – coherent pathways to desired futures of democracy in the European Union in 2040. We translate our main objective into a series of research questions that need to be answered to support the work. Each question is connected to a key objective and corresponding work packages to support co-creation. The questions and objectives, presented below, are in order of workflow, not in order of importance. All activities are planned to be inclusive and open processes – transparently documented along the way – to enable repetition and implementation beyond the life of the project. The project’s ambition is to reinvigorate democracy in and across Europe with visions and pathways -- made with active and inclusive citizen participation -- for becoming more resilient to current and future challenges.

Keywords: participatory deliberations democracy scenarios visions
Satisfiability and group rings (SATURN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1207875.0
EU funding (EUR): 1207875.0
Participants: 1
Project status: SIGNED

Group rings are key objects in many fields of mathematics including algebra, topology, operator algebras and representation theory. Fundamental questions about them remain unanswered, in particular several conjectures attributed to Kaplansky. For torsion-free groups and field coefficients, the zero divisor conjecture predicts the absence of zero divisors and the idempotent conjecture predicts that 0 and 1 are the only idempotents in the group ring. The direct finiteness conjecture says that left-invertible elements are invertible in group rings of arbitrary groups over fields. These conjectures have a history spanning more than 80 years. Although special cases are known, resolving any of the conjectures in full generality seemed intractable until the recent disproof of the closely related unit conjecture. The goal of this project is to construct counterexamples to the zero divisor and direct finiteness conjectures. The latter will give the first example of a non-sofic group. We also seek to resolve the unit conjecture in characteristic zero. Key to our approach is the application of modern solvers for Boolean satisfiability. This paradigm shift, which was successful against the unit conjecture, shows that these problems are substantially more vulnerable to computational techniques than previously thought. Constructing our counterexamples will require both developing our understanding of candidate groups and their properties and building a toolkit for the effective application of existing computational machinery. The unique product property obstructs the existence of counterexamples to these conjectures and is thus of great interest. We will answer fundamental questions about this property. Although we focus on the positive characteristic case, this project will lay serious groundwork towards the construction of counterexamples in characteristic zero to the zero divisor and idempotent conjectures and thus to the Atiyah, Baum-Connes and Farrell-Jones conjectures.

Keywords: group rings,geometric group theory,unit conjecture,zero divisor conjecture,sofic groups,boolean satisfiability
Distributed learning based on 1-bit gradient coding (1-Bit GC-DL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-06
End date: 2026-11-05
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

In the framework of distributed learning, to mitigate the negative impact of the stragglers on the training time, the gradient coding (GC) technique has been adopted. On the other hand, to deal with high communication burden in distributed learning, 1-bit gradient vectors can be transmitted instead of real-valued ones. However, the existing distributed learning method based on 1-bit data does not take stragglers into account. In addition, current GC techniques are only designed for the distributed learning scheme where real-valued encoded vectors are transmitted and it is difficult to apply them under the case where 1-bit vectors are transmitted. To overcome the above drawbacks and to reduce the communication overhead and the training time simultaneously, this project aims to propose novel distributed learning methods based on GC with 1-bit data. First, this project will propose a distributed learning method named 1-Bit GC-DL, which develops a 1-bit GC strategy to encode the locally computed gradient vectors of the allocated subsets into 1-bit data. Based on that, the aggregation rule at the central server for the received 1-bit data will be designed, which guarantees that the central server computes an approximated version of the true gradient vector in the presence of a certain number of stragglers to. Second, to further reduce the training time of 1-Bit GC-DL, this project will propose a lazily aggregated distributed learning method based on 1-bit GC, i.e., 1-Bit LA-GC-DL, by combining 1-Bit GC-DL with the lazily aggregated strategy. In 1-Bit LA-GC-DL, only a fraction of the workers participate in local training during each iteration and this project will provide the criterion for selecting the participating workers based on Age of Information. The proposed methods will be compared with other state-of-the-art methods in the context of distributed learning on both simulated and realistic datasets under practical scenarios.

Keywords: distributed learning,gradient coding,1 bit data,stragglers,training time,communication overhead
Collective Regulation of Cell Decisions (CoRe)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 2486429.0
EU funding (EUR): 2486429.0
Participants: 1
Project status: SIGNED

Developing systems show an unmatched complexity due to an entangled regulation across different levels of organization. Errors in this regulation often lead to tissue and organ malformations and disease. Accordingly, cell decisions like division, fate or motility are not only guided by local signals generated at the cell micro-environment, but also integrate cues propagated by collective properties at the tissue-level, such as tissue rigidity. How the cell’s macro-environment impacts cell decisions is still elusive, largely because we lack methods and concepts to identify and eventually control collective tissue properties. I will tackle this question by harnessing the physics of collective behaviours as design principles for synthetic in vivo developmental biology. We build on our discovery that embryonic tissue rigidity emerges via phase transitions, only when a simple cell parameter, cell connectivity, reaches a specific but generic value, the critical point. By identifying the responsible cell parameters and their critical points, we will build tools to tune those parameters, engineer for the first time, a set of tissue physical properties in vivo and explore their role in cell decisions. We will use the developing zebrafish as a model and: Quantitatively map cell parameters and the critical points at which tissue properties emerge; Control tissue properties by opto-genetically tuning the responsible cell parameters in relation to the critical points; Dissect mechanisms of collective regulation of cell polarity and fate decisions at single-cell resolution; Derive generic principles of multiple cell decision-making by comparing species operating near or far from critical points. Uncovering how collective properties impact cell decisions will reveal mechanisms of tissue development transcending biological scales, generate new hypotheses of how developing systems optimise biological functions, and inform strategies for tissue engineering and disease treatment.

Keywords: collective properties,phase transitions,embryo complexity,criticality
Valorization Legumes Related Ecosystem Services (VALERECO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Greece,France,Netherlands,Portugal,Serbia,Germany,Spain,Lithuania,Italy,North Macedonia,Switzerland
Call: Valorisation of ecosystem services provided by legume crops (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 4901731.25
EU funding (EUR): 4899856.25
Participants: 15
Project status: SIGNED

VALERECO target is to promote adoption and understanding the value of legume crops towards transition to sustainable, productive, climate-neutral, environment-friendly and resilient farming systems. The project aims to quantify and enhance the environmental and economic value of ES provided by 4 minor or underutilized and 8 major legume crops. It seeks to encourage diversification of farming practices throughout the EU and Associated Countries, which can contribute to healthier and sustainable diets and climate change resilience. The identification will be achieved through: (1) a thorough analysis on the ecosystem-services legacy and (2) the investigation of gateways for penetration of legumes and their associated ES to the new CAP. The valorization will be implemented through the establishment of nine Living Labs (LLs) to conduct: (1) behavioural design strategies to promote the adoption of legumes in production and consumption, (2) on-station participatory trials to assess the performance of major and minor-underutilised legume crops in diversified farming systems, (3) to demonstrate and co-create technical economically and environmentally assessed solutions for legumes inclusion in cropping systems. The dissemination will be realized through: (1) the development of a Digital Legume Information Hub (DLIH) to upscale and maximize the uptake of VALERECO’s results, (2) the development of a Decision Support System (DSS) to support the decision-making of farmers and advisors for legumes adoption, and (3) the generation of capacity building material made available to the public through an E-learning Platform.

Keywords: legumes ecosystem services legume based diversified cropping systems crop rotation capacity building cost benefit analysis life cycle assessments living labs agroecology 3d diversification
DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS (PAS GRAS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Portugal,Italy,Sweden,Spain,Netherlands,Germany,United Kingdom,Poland
Call: Prevention of obesity throughout the life course (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 9377421.25
EU funding (EUR): 9377421.25
Participants: 16
Project status: SIGNED

PAS GRAS aims to prevent and reverse obesity and associated metabolic complications in four age groups: pre-pubertal children (3-9 yr), adolescents (10-18 yr), young adults (19-25 yr), and adults (25-55). PAS GRAS focuses on four main pillars. 1) Develop a personalized risk assessment tool (RAT): an algorithm that will anticipate obesity priming and development in the critical age groups, and identify risk factors for specific complications in subsequent years that will constitute new outcomes for interventional studies. 2) Develop and implement RAT-based personalized interventions by integrating non-pharmacological lifestyle modifications including Mediterranean Diet components alone or with rational pharmacological targeting metabolic and neuroendocrine mechanisms. 3) Inform and engage effectively target groups on obesity causes, risks and intervention by co-production of creative and interactive digital tools (including a simpler version of the RAT) and personalized diet and physical activity programs. 4) Expand and consolidate the PAS GRAS tailor-made campaign across Europe through developing joint programs for health and food/nutrition literacy and physical activity, with healthcare centres, schools, sports clubs, municipalities, and other relevant actors and public authorities. PAS GRAS outcomes will contribute to a long-term 15% decrease in overweight/obesity prevalence in adults and 30% in children/adolescents in the EU until 2050, contributing to a downstream reduction of obesity-associated complications, pharmaceutical and surgical interventions, and to promote Mediterranean Diet as tool for a more nutritious and sustainable future. PAS GRAS is a unique multi- and interdisciplinary research team from 8 countries, including 12 top-level Universities and Research Institutions. Non-academic partners include a civil organization, one company, one patient organization and one Pan-European research Society.

Keywords: overwheight obesity,biological and metabolic pathways,socioeconomic and environmental factors,mediterranean diet,physical activity,science health literacy,co production,tailored interventions
TREM2 MICROglia ENGENEering for treating dementiaS (TREM2MICROENGINES) (TREM2MICROENGINES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-07-01
End date: 2023-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The project TREM2MICROENGINES aims at demonstrating that raising and restoring TREM2 expression in the brain of Alzheimer’s disease (AD) and Nasu–Hakola disease (NHD) patients, and in particular in their microglia, would result in therapeutic benefit. AD is a severe neurodegenerative disorder that represents the most frequent form of dementia among the elderly which affects approximately 5.1 million Americans and this number is supposedly tripled by 2050. AD is believed to result from the deposition of extracellular amyloid-β (Aβ)-containing plaques. TREM2-Triggering receptor expressed on myeloid cells 2 is a microglia cell-surface receptor whose deficiency or haplo-insufficiency augments Aβ accumulation due to a dysfunctional response of cells, which become apoptotic. Homozygous, loss-of-function mutations in TREM2 also cause the autosomal recessive disorder NHD, a ultra-rare inherited disease of the white matter (WM) with typical onset in the adult age, and patho-physiologically characterized by microglial dysfunction (microgliopathy). The key clinical feature of NHD is progressive presenile dementia usually leading to death in the fifth decade of life NHD patients also lack curative treatments. A relevant proportion of AD cases and all forms of NHD are caused by pathogenic mutations in the Trem2 gene which lead to microglia dysfunction contributing to and/or causing the onset and manifestations of AD and NHD. Based on this provision, our working hypothesis is that transplantation of HSCs engineered by LVs to express robust TREM2 levels in response to tissue damage in CNS-engrafted myeloid/microglia cells would modulate neuroinflammation, restore physiological microglia functions and contribute preventing and reducing Aβ accumulation in the CNS of AD and NHD patients. No existing approaches currently allow targeting microglia dysfunction in AD or in NHD, nor at enhancing microglia specific function through a microglia-targeted TREM2 delivery/engineering.
Frontier RESearch COmpetences for Neuro-modulation and Oscillations in Pain (FRESCO4NoPain)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark,France,United Kingdom,Germany,Belgium,Estonia,Finland,Spain,Netherlands,Austria
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 4167943.2
EU funding (EUR): 4167943.2
Participants: 20
Project status: SIGNED

Chronic pain is a major societal and economic European burden, affects one in five adults, and its inadequate relief indicates a major unmet need for effective and mechanism-based non-pharmacological treatments. In FRESCO4NoPain, we propose that maladaptive brain oscillatory activity is associated with persistent pain, and that non-invasive brain neuromodulation may provide a novel treatment strategy. For this, mechanistic insight is needed. We see this as the perfect opportunity to unite world-leading experts in pain neuroscience to train 17 uniquely skilled Doctoral Candidates (DCs) who will become the future generation of pain scientists, fully equipped to address unmet challenges within chronic pain. The DCs will be integrated in a one-of-a-kind network-wide training infrastructure conducting frontline research on non-invasive brain stimulation that targets persistent pain based on i) preclinical studies of the relevant brain circuitries, ii) human studies of the involved mechanisms, and iii) clinical studies. Through FRESCO4NoPain, DCs will access a unique set of basic, experimental, and clinical disciplines in both academic and non-academic settings, tied together by synergistic collaborations across the network. An application-based and patient-oriented mindset will permeate the consortium via the active involvement of cutting-edge MedTech companies, knowledge actors and end-users. Only such a truly interdisciplinary and intersectoral approach can provide the necessary ecosystem to go beyond the state-of-the-art, promote disruptive thinking while developing new methods that overcome current technological barriers in the complex field of interdisciplinary pain neuroscience. FRESCO4NoPain will deliver on urgently needed non-pharmacological therapeutic concepts for chronic pain and build on fundamental scientific insights regarding the role of neuronal oscillations in the brain processing of pain, thereby potentially helping millions of people with chronic pain.

Keywords: oscillatory signatures of pain functional connectivity changes and pain measures pain phase locked eeg rhythms top down control of pain cortical stimulation evidence for chronic pain