Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Herbicide Resistant Rice Development For European Continental Project (HerbaRice)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Türkiye,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-16
End date: 2023-11-15
Duration (months): 36.0
Total project cost (EUR): 255943.68
EU funding (EUR): 255943.68
Participants: 2
Project status: SIGNED

Global rice production, so far, has been able to meet population demands. Rice production is considerable exposed to the environment and natural detrimental affect especially weed and weedy rice problems. Present herbicides are often suffered to kill weed and weedy rice that allows for more chemical usage and non-sustainable rice production system. Weed and weedy rice are a great problem because of resistancy and cultivation system such as direct seeded area, especially in Europe. In order to control the problem, Clearfield and Provisia technology developed in the United States. But some weed species or weed varieties are getting resistant to Clearfield rice in Europe in the last years. Thus, new alternative tools are needed for weed control. The main aim of the project is develop to non-GMO herbicide resistant new base rice for European countries. Herbicide resistant new base rice might be utilized control weed and weedy rice where gained resistance against to conventional rice herbicides in the fields. Project will investigate to develop non-GMO resistancy with Clethodim (Cyclohexanedione-Dim Group) herbicide resistance for rice. For this reason first objective is execute a mutation on rice seeds, second is develop to low and high resistancy on rice plant, the next objective is determination of mutation point on mutagen resistant rice. Last objective is investigated to deterioration of currently utilized herbicide resistancy system on especially the basis of IMI resistant red rice at incoming phase. The new resistancy system might be available to use when Clearfield and Provisia technology break down because of gene flow and misusage. The HerbaRice project will give new insights on weed and weedy rice problem on rice fields, providing new tools for herbicide resistancy producing safer and sustainable food production.

Keywords: rice oryza sativa l,weed,red rice,herbicide,herbicide resistance,mutation,breeding,ethyl,methane sulfonate,molecular marker,non gmo,clethodim
Situated Learning Opportunities fostered by ICT applications in Alternative Agro-Food Networks (SOFIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-01-31
Duration (months): 20.0
Total project cost (EUR): 162879.0
EU funding (EUR): 162879.0
Participants: 1
Project status: CLOSED

The training-through-research project SOFIA - Situated Learning Opportunities fostered by ICT applications in Alternative Agro-Food Networks- aims at enhancing the researcher potential to make broad his horizons and support his career development. In the light of his research objectives he will acquire new knowledge and transfer that one previously developed to the host organization The SOFIA project will allow the ER to became a key facilitator of multidisciplinary research and innovation teams, applying his interdisciplinary competences in service design for innovation, thus ensuring an independent position to the researcher and his future employability in the academic and/or non-academic context. The research SOFIA aims to analyze innovative organizational models and explore the value of the use of ICT tools (e.g. ubiquitous mobile services) to increase Situated Learning Opportunities (SLOs) in an Alternative Agro-Food Networks (AAFNs), through two methodologies i.e multi-case study analysis of local food systems and rural areas and a web-survey of ICT tools for AAFN. The expected impact of the research is to define a set of reproducible methodologies, models, tools and technologies that can improve the competitiveness of a selected area, leveraging its potential in terms of materials and intangible resources. In addition, the study will aim to analyze ICT tools supporting the information flows management both for decision making and for operational processes in the identified collaborative networks. The researcher will carry out specific actions to disseminate project results and increase their fruitful exploitation, e.g.SOFIA’s results will be exploited to draw up guidelines based on innovative organizational models, tools and ICTs to support the dynamics of sustainable development in local food systems and to design and develop Mobile services to support SLOs in AAFNs in order to improve mutual understanding and collaboration between value chain stakeholders.

Keywords: short food supply chain,rural ares development,sustainability,collaborative networks,social learning,mobile learning
CLEAN clinKER production by Calcium looping process (CLEANKER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Estonia,Italy,Germany,Germany,Germany,Italy,Italy,Spain,Italy,Finland,China,Switzerland,Czechia
Call: CCS in industry, including Bio-CCS (H2020-LCE-2017-RES-CCS-RIA, 2017)
Start date: 2017-10-01
End date: 2023-03-31
Duration (months): 66.0
Total project cost (EUR): 9237851.25
EU funding (EUR): 8972201.25
Participants: 18
Project status: SIGNED

Calcium looping (CaL) is one of the most promising technologies for CO2 capture in cement plants. The process comprises two basic steps: (1) “carbonation” of CaO to form CaCO3 in a reactor operating around 650°C; (2) oxyfuel calcination in a reactor operating at 920-950°C, which makes the CaO available again and generates a gas stream of nearly-pure CO2. The CLEANKER project aims at demonstrating at TRL7 the CaL concept in a configuration highly integrated with the cement production process, making use of entrained flow reactors. The highly integrated configuration allows achieving high energy efficiencies, with CO2 capture efficiency over 90%. The adoption of entrained flow gas-solid reactors is particularly suitable - and familiar - to the cement industry. The core activity of the project is the design, construction and operation of a CaL demonstration system comprising the entrained-flow carbonator (the CO2 absorber) and the entrained-flow oxyfuel calciner (the sorbent regenerator). This demonstration system will capture the CO2 from a portion of the flue gas of the cement plant in Vernasca (Italy) operated by Buzzi Unicem, using as CO2 sorbent the same raw meal used for clinker production. Other activities will include: (i) screening of different raw meals to assess their properties as CO2 sorbent, (ii) reactors and process modelling, (iii) scale-up study, (iv) economic analysis, (v) life cycle assessment, (vi) CO2 transport, storage and utilization study (vii) demonstration of the complete value chain, including mineral carbonation of waste ash with the CO2 captured at Vernasca; (viii) exploitation study for the demonstration of the technology at TRL>7 and for its first commercial exploitation based on CO2 transport and storage opportunities.

Keywords: calcium looping,cement production and co2 capture and storage
Biotechnology for investigating cell fate choice (CellFateTech)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2022-11-30
Duration (months): 56.0
Total project cost (EUR): 1876618.0
EU funding (EUR): 1876618.0
Participants: 1
Project status: TERMINATED

The evolution from a stem cell to differentiated progeny underpins tissue development and homeostasis, which are driven by a multitude of cell fate choices. The transitions underlying these choices are not well understood. There are a number of challenges that must be overcome to achieve this understanding. In the proposed research we will tackle two of the challenges: first, the dynamics of fate choices, i.e. the dependence of transitions on time and inductive signals, remains cryptic; second, mechanical signalling regulates instructive cues for transitions but its role in the process is uncertain. One of the primary reasons these important aspects of cell fate choice remain a mystery is because the biology has not been coupled to the biotechnology appropriate to unravel it. This is the purpose of the proposed research: we will develop tools based in microfluidics, microfabrication and hydrogels and integrate them with our stem cell biology expertise to illuminate the process of cell fate choice. We will develop single cell microfluidic technology that possesses unprecedented temporal resolution and control over the signalling environment to study cell fate dynamics. We will also synthesize hydrogel substrates to exert complete control over the mechanical microenvironment of stem cells. Finally, we will advance tools to apply reproducible and defined forces to cells in order to study the role mechanical signalling in cell fate choice. Developing the proposed technology kit hand-in-hand with its biological applications will allow us to delve into the mechanisms of biological transitions in multiple stem cell systems, allowing us to uncover universal phenomena governing cell fate choice.

Keywords: biophysics,mechanical signalling,cell fate,cellular transitions
New Technology for High Resistant and Flexible Fabric Structures (Modules)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global fabric structure market has evolved at a value of €713M and 7.9M m2 of end products in 2016 due to their variety in shapes and constructions, durability in external forces and incidents, recyclability, and high strength-to-weight ratio which have enabled them to be utilised in a wide range of applications-varying from small to large, inside to outside and temporary to semi-(permanent)-in the events, business/industry and sports sectors. Nevertheless, the industry is facing continuous user’s demands for more engineered structures and solutions aiming to tackle the following needs: 1) Structural reinforcement to achieve higher resistance to adverse weather conditions such as extreme winds,storms and heavy snow, 2) Modular Structures that will enable for flexibility, ease, high secure and rapid installation and efficient space utilization, 3) High-end structures responding to the current market trend that is pushing away traditional fabric structures. Our novel Modules technology represents the next generation of high-end modular fabric structures as we answer in a cost-effective way to the structural musts of the fabric structures industry. Based on a ground-breaking developed add-on concept and by assembling the roof as well as claddings from the ground level we are able to provide a new standardised structure solution to satisfy the actual market needs of speed, security and total flexibility during installation process with the construction on different widths (up to 50m) and heights (up to 12 m). What is more, Modules system enables structures to be adequately reinforced to resist unpredictable climatic changes such as sudden heavy winds, rain and snow and additional roof live loads (lights, audio equipment, HVAC). We have identified a total addressable market (TAM) of around €300M by 2025. We have estimated that this will lead our company to a business opportunity of of cumulated revenues and profit of €31.5M and €6.3M respectively.

Keywords: innovative add ons,fabric structures,high resistance,roof load resistance,climatic adversities,modular solutions,temporary and semi permanent installations,events industry,secure installation
Adaptive and resilient production and supply chain methods and solutions for urgent need of vital medical supplies and equipment (CO-VERSATILE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced manufacturing and processing
Action type: Innovation actions
Countries involved: Austria,Germany,Spain,Germany,Italy,Germany,Spain,Germany,Germany,Italy,Italy,Israel,Switzerland,Hungary,Hungary,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Repurposing of manufacturing for vital medical supplies and equipment. (H2020-SC1-PHE-CORONAVIRUS-2020-2-NMBP, 2020)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 6274042.5
EU funding (EUR): 5374140.38
Participants: 29
Project status: SIGNED

CO-VERSATILE aims at increasing the adaptation capacity, resilience and flexibility of the European manufacturing sector, focussing on vital medical supplies and equipment, to support Europe in improving its response and preparedness to deal with pandemics. CO-VERSATILE builds upon research and innovation industry-driven initiatives to deliver demonstrators of a flexible 48-hour industrial response capability at scale, to cope with sudden spikes in demand of strategic products, for requalification or release of Manufacturing Settings. The project foresees four key objectives: - Deliver a rapid response to the ongoing emergency situation in the re-orientation and repurposing of production capacities through repurposed MVP for 7 manufacturing settings at M2 of the project and improved results iteratively delivered every 3 months after that, allowing an increased production capacity of vital medical supplies and equipment. Manufacturing settings outside the project will start having access to the project results at M6 of the project through a digital platform - Set up an accessible and democratic Digital Technopole for the re-orientation and repurposing of production capacities to meet the urgent needs of our societies for vital medical supplies and equipment, consisting of 5 operational building blocks. - Validate the proper operation of the Digital Technopole on 7 selected Manufacturing Settings to demonstrate a flexible 48-hour industrial response capability at scale, to ramp up production in response to sudden future spikes in demand of strategic products (for instance medical equipment such as PPE, respirators), for requalification or release of production lines. - Ensure the sustainability of the Digital Technopole and the multiplication of the offered services to the European Manufacturing Industry to achieve wide replication.

Keywords: manufacturing,repurposing,medical supplies and equipment,pandemic,rapid response,production adaption,digital platform,technologies,simulation
NAno SCintillator ARrays (NASCAR) as a Novel Nuclear Detection Material (NASCAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-15
End date: 2024-12-14
Duration (months): 36.0
Total project cost (EUR): 289732.8
EU funding (EUR): 289732.8
Participants: 2
Project status: SIGNED

Detection of special nuclear materials (SNM), is of vital importance to prevent nuclear terrorism and to secure states’ national security. Neutron detection is a particularly useful tool to identify SNM and neutron-sensitive scintillators have many promising properties, such as ease of use, good time resolution, and high detection efficiency. In this project we develop a new state-of-the art neutron sensitive scintillator using on nanostructured scintillating materials. Based on the early advancements that our research team has made, we propose Li (or B) incorporated nanostructured ZnO devices for highly efficient thermal neutron detection. These devices use a novel nanorod array design that greatly increases the effective surface area and efficiency of the sensor. Cost effective low temperature hydrothermal growth is used to obtain ZnO nanorod arrays. The state-of-the-art design of the nanorod array combines the key advantages of a low cost growth technique together with environmentally friendly and widely available materials. The Global Fellow (GF) has outstanding experience in Nuclear Science and Technology and has wide expertise in radiation and nuclear physics. The supervisor at the partner organization (Georgia Tech, USA) is a renowned Professor in radiation physics and holds a highly relevant patent. The supervisor at the beneficiary organisation (University of Surrey, UK), has a strong background in the physics of materials for new detectors and has recently developed novel nanocomposite scintillators and organic neutron detectors, both of which are highly relevant to the project. The GF worked on neutron measurements under the supervision of the host at Georgia Tech between 2013-2015, and therefore has the required expertise to deliver this program through effective collaboration with both partner institutions.

Keywords: nanoparticle scintillator nuclear security
FINEST TWINS (FINEST TWINS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Estonia,Finland
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 449188.0
EU funding (EUR): 449188.0
Participants: 4
Project status: CLOSED

There is a clear political and business interest in strengthening the cooperation between the cities of Tallinn and Helsinki, and Estonia and Finland respectively, in terms of research, innovation and economic development (Twin cities mindset). A recent policy report by OECD suggests to extend the definition of Tallinn-Helsinki cross-border area to the greater Helsinki (Uusimaa), and Estonia to the entire country, considering the comparable population (1.3-1.4 m), Helsinki’s close scientific and innovation ties to Tartu, the Estonian second largest city, and the fact that innovation policies are implemented at national level in Estonia whereas regional level in Finland. Building on the political, social and economical support both in Estonia as well as in Helsinki city, this proposal provides a good opportunity to kick-start a closer cooperation through the planning and development of a Smart City Centre of Excellence joint venture in Tallinn. The ICT driven Smart City CoE would act as a hub capable of combining the scientific knowledge, innovation capacity and entrepreneurship of all relevant actors in Estonia and the greater Helsinki region. This proposed FINEST TWINS joint venture is based on smart specialisation strategies and marks a new model for close cooperation. Estonia will benefit from Helsinki region expertise, its living labs methodologies knowledge and public-private multiple ventures as Helsinki is one of the top European Smart Cities. Helsinki will also benefit from Estonia public innovativeness in the uptake of e-Government services, overall agility and comprehensive citizens capacity to embrace new digital service solutions, making it one of the best test-beds in the world. The CoE will be the first EU cross border Smart City solutions and demo lab capable of provide urban services and attract international expertise and investment, as well as, act as a springboard for the exportation of Finnish-Estonian knowledge and service solutions on a global scale.

Keywords: smart city,smart living,smart environment,smart mobility
Activation of Src kinases through dimerization suggests novel therapeutic opportunities (Src dimerization)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Bulgaria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2023-05-31
Duration (months): 36.0
Total project cost (EUR): 182721.6
EU funding (EUR): 182721.6
Participants: 1
Project status: CLOSED

c-Src, the first proto-oncogene to be identified, controls many aspects of tumor biology including the capacity of the cancer cells to multiply, survive, and metastasize. We recently discovered that c-Src forms dimers and that dimerization is essential for the activity of the enzyme. This represents a significant paradigm shift in our understanding of the biology of Src family kinases, which until recently were assumed to function as monomeric proteins. The discovery that c-Src functions as a dimer creates the basis for development of a novel class therapeutics in principle based on disruption of Src dimerization. Our preliminary data indicate that such dimerization inhibitors have dramatic anti-tumor activity, suggesting that the proposed research may lead to development of an effective anti-cancer therapy. The project goal is to accomplish the following specific objectives: 1. To determine the efficacy of inhibition of Src myristoylation and dimerization for treatment of cancer; 2. To develop competitive inhibitors of Src dimerization and activity. The project will also create opportunities of boosting the research and innovation capacity of Europe, for obtaining IPRs, commercialization, and setting new collaborations with top US research institutions and companies. The proposal is intended as a career development fellowship that is designed to facilitate my reintegration into the EU science and to further my career towards a leading independent research position. I am confident that the quality and excellence of science produced and the new research and complementary skills obtained during the fellowship will serve as a cornerstone for my future career advancement and mark the beginning of my new laboratory and research program.

Keywords: cancer,tyrosine kinases,myristoylation inhibitors,targeted therapy