Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Viral Haemorrhagic Fever: Modern Approaches for developing bedside Rapid Diagnostics (VHFMoDRAD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Italy,Germany,Italy,Türkiye,Belgium,Sweden,France,France,France,France,Denmark,United Kingdom,United Kingdom,Senegal
Call: Ebola and other filoviral haemorrhagic fevers (Ebola+) programme: future outbreaks (H2020-JTI-IMI2-2015-08-single-stage, 2015)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 5050012.5
EU funding (EUR): 3316012.5
Participants: 17
Project status: SIGNED

VHFMoDRAD will develop and deliver rapid and point-of-care singel/multiplex diagnostic tool(s) that will significantly increase our capacity to handle outbreaks with Filoviruses and other viral hemorrhagic fever diseases in Africa. The overall aim of VHFMoDRAD is to carry on the outcome of the currently running EbolaMoDRAD project to the next level, which is behind of the scope of that project. The goals of VHFMoDRAD will be done via a multidisciplinary research consortium drawn from key European and African research organisations and also industry and SMEs, thus consolidating previous tools and knowledge. VHFMoDRAD will also put in place a strong capacity building programme in West Africa The project will disseminate widely all results as they become available, notably to public health bodies and non-governmental organisations (NGOs), via a strong outreach programme. To achieve this overall aim an intensive work plan will be put in place, with the following specific objectives: - to develop rapid molecular and serological single/multiplex detection methods; - perform preclinical validation of diagnostic tools; - to validate the successful diagnosis tools under field conditions; - implement a strong capacity building programme in West Africa by a twining program; - to exploit results; - to disseminate the results to public health bodies, NGOs, outbreak management teams and local hospitals in West Africa.

Keywords: poct,rapid early detection,multiplex,ebola,twinning,capacity building,validation
A fast non-intrusive vapour detection system that rapidly identifies explosives in public areas (AirBrush)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-04-01
End date: 2020-12-31
Duration (months): 33.0
Total project cost (EUR): 1529150.0
EU funding (EUR): 1070405.0
Participants: 1
Project status: CLOSED

Terrorism has become the most prominent security issue of the 21st century and fighting terrorism is a top priority. Our society has been the target of a series of deadly terror attacks in recent years. A total of 11,072 terrorist attacks occurred worldwide in 2016, resulting in more than 25,600 total deaths and more than 33,800 people injured. Explosives were used in 54% of the attacks. Explosives or bombs can be made easily at home and hidden simply in a suit or under clothes, making it impossible to notice without specialised equipment. Existing solutions such as X-ray machines, security scanners and body search, are not capable of detecting explosives as such: they merely detect objects which might be explosives. In addition, they often require the direct involvement of security staff, resulting in time-consuming procedures. Therefore, even simple bag or body screening can significantly increase the waiting time and crowd. The Eye on Air solution is a fast non-intrusive screening system for detecting explosive materials in public areas. The key innovation lies in an ultra-compact Ion Mobility Spectrometry (IMS) sensor, capable of detecting any kind of explosives as required by the European Civilian Aviation Conference (ECAC) within 2-5 seconds. The first application of the IMS technology will be AirBrush, a shoe-specific explosive vapour detection system for airports. AirBrush is the first effective shoe-specific explosive detection system, enabling seamless and quick screening of 100% passengers while significantly cutting waiting time in line and operational costs for security. The overall objective of AirBrush innovation project is to optimize the AirBrush design and validate its performance through pilot test with NCTV at Schiphol Airport (one of the largest airport in Europe) in order to obtain relevant certification and credibility.

Keywords: security,terrorism,explosive,explosive vapour detection,explosive trace detection,ion mobility spectrometry,airport
Computational Prediction and Validation of RNA thermometer at transcriptome-wide scale in living cell (ComPreValRther)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Temperature is crucial to plants’ growth and development. The cold and heat stresses may drastically inhibit plant growth and cause yield losses in crops. Understanding the temperature responding mechanism is crucial to adapt the crops to withstand extreme temperature changes caused by global warming. Among other temperature regulation mechanism, RNA thermometers (RNATs) can instantaneously respond to temperature shift and directly control translational efficiency therefore protein abundance. To date, no RNAT has been identified in plant mainly due to the fact that instead of sequence level conservation, RNATs only have structure level conservation; also because in-vivo RNA structure probing used to be technically challenging. The host lab has developed a powerful platform for in vivo RNA secondary structure probing at both targeted individual RNA and genome-wide scale. This proposed study aims to globally identify RNA thermometers in plants for the first time, and to quantitatively elucidate the role of RNA structure in the post-transcriptional regulation of gene expression in response to temperature. I will measure the alteration of in vivo RNA structural features in Arabidopsis thaliana under different temperature regime. Additionally, Ribosome profiling data and RNA-Seq data will be combined to study the translation efficiency under the corresponding temperature. Together with the identified significantly changed RNA structure elements, we will be able to determine the putative RNAT. Finally, I will validate the predicted RNATs through studying nature variations. I will perform in-vivo RNA structure probing and determine whether the identified single nucleotide variations (SNV) will have significant effects on temperature-regulatory elements. Besides the potential for crop improvement, our approach to globally measure RNA secondary structure and the corresponding translation efficiency will be easily applied to other organisms and various environmental stimuli.

Keywords: rna thermometer,rna structure,structure seq,translation
Linear Innovative Thrust Reverser Actuator System (LiTRAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Germany,Spain
Call: Innovative Thrust Reverser Actuator System (ITRAS) (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-09-01
End date: 2023-02-28
Duration (months): 30.0
Total project cost (EUR): 1158855.0
EU funding (EUR): 901380.0
Participants: 3
Project status: SIGNED

LiTRAS will develop a robust concept for an innovative Thrust Reverser Actuator System (TRAS) based on linear motor technologies that will allow further and deeper integration capability inside the pylon and nacelle structure and will greatly improve Thrust Reverser performances against the challenging Nacelle environment. The LiTRAS concept will be compact, safe, reliable and easy to operate and will be able to withstand the harsh environmental conditions required. In addition, LiTRAS concept will provide locking functionality (PLS, Primary Locking System) preventing from any inadvertent Thrust reverser deployment in Flight and a Mechanical Deployment Unit (MDU) for manual opening of the cowls for maintenance operations. The system will also incorporate a TRCU (Thrust Reverser Control Unit) concentrating the power supply, control and monitoring electronic hardware of the linear actuator. The main objectives of the LiTRAS project are: • Investigate linear motor technologies applied to a thrust reverser module of a short middle range UHBR engines with further and deeper integration capability inside the pylon and nacelle structure. • Improve cost, weight, efficiency and maintainability of the Thrust Reverser Actuation System by developing a compact, reliable actuator based on a linear motor without mechanical transmission and directly integrated with the nacelle structure. • Investigate on the possible solutions that could be given to extreme environmental conditions if required. • Bring the technology to TRL4 • Contribute to the reduction of the development time of the future engine architectures by 10%, through the optimisation of system integration for the power plant systems • Provide a friendly design that is easy to use but ensures a safe operation of the TRAS. • Deliver an Aircraft qualification assessment and define the necessary steps to bring the technology from TRL4 to an aeronautical and certifiable equipment.

Keywords: linear motor,electromechanical actuator,thrust reverser actuator system,tras,aircraft,nacelle,ubpr
A Part to Play: How Caregivers Shape Infants' Visual Exploration and Alter Their Neural Mechanisms of Attention (InterPlay)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2023-07-26
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: SIGNED

Infants learn and develop at incredible speed. Although relatively helpless at birth, infants undergo significant development in the first year of life in many domains. But how do infants learn so quickly? They likely gather information that is optimal for learning by systematically allocating their visual attention to specific types of stimuli. Allocation of visual attention can be (1) intrinsically driven to guide their explorations in the world, or (2) guided by other social agents. Moreover, infants’ intrinsic visual exploration may be dependent on the “hardware”: the brain. This project aims to develop a comprehensive account of how these mechanisms interact in full-term and pre-term infants. Visual exploration and attention is often disrupted in pre-term infants, which may contribute to developmental delays. Since the World Health Organization estimates that 15 million infants are born pre-term annually, it is crucial to investigate how infants visually explore their environment and how this can be promoted through social interactions. Research into infants’ visual attention has been conducted by scientists from various fields, but few attempts have been made to integrate these findings into a comprehensive framework. As such, the interplay between these factors remains unknown. This lack of integration causes severe gaps in our theoretical understanding, hindering the development of healthcare policies and interventions. InterPlay addresses these knowledge gaps by integrating previous observations into a comprehensive, longitudinal study. The findings will have implications for current scientific and therapeutic practices. If caregiver attention-guiding behaviours could compensate disruptions in pre-term infants’ visual exploration, this would offer great potential for interventions early in life. Furthermore, infants’ brain connectivity may provide a unique predictor for the necessity of intervention, allowing healthcare providers to act in a timely manner.

Keywords: cognitive development,parent child interaction,visual attention,curiosity driven learning,functional connectivity networks
Biomaterial based Microwave Antennas for Communication and Sensing applications (BMACS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: TERMINATED

Design and development of biomaterial based wearable, conformable and planar microwave antenna for biomedical, communication and telemetry application is proposed in this project. The project targets a new innovative field comprising of Material science, Microwave Engineering, and Biomedical Sensing. The usage of biomaterials as a substrate in microwave application will reduce the electronic waste, thereby protecting the environment. This project aims to identify at least three biomaterials with suitable synthesis methods leading to the fabrication of microwave substrate to enable conformal biomedical sensing, radio telemetry (Transmitting antennas used to track animals and birds in the forest or other sensitive environments) applications, antennas for the Internet of Things (IoT), ISM and 5G applications. Keeping these application possibilities, I would like to extend the research horizon of biomaterial based microwave devices and to establish this prospective research area, which will be having the highest research priority in the future considering the biological and environmental aspects. High efficient conformable antennas, planar antennas and wearable antennas suitable for sensing, communication and telemetry applications using biomaterials will be developed, which is an innovative aspect of this proposal. The research area of this proposal is not only interested for the scientific community but also beneficial for the whole human and living beings, since the replacement of non-biodegradable materials with biodegradable material in electronic gadgets will tremendously reduce the e-waste content of our planet hence causing a bigger positive impact to the ecosystem in total.

Keywords: microwave antenna,conformal antennas,bio electromagnetics,microwave material characterization,biomaterials
Na-Ion bAttery Demonstration for Electric Storage (NAIADES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Sweden,Belgium,France,France,France,France,France,France,United Kingdom
Call: Next generation technologies for energy storage (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 6492262.5
EU funding (EUR): 6492262.0
Participants: 17
Project status: CLOSED

Wide scale implementation of renewable energy will require growth in production of inexpensive, efficient energy storage systems. The extension of battery technology to large-scale storage will become necessary as intermittent renewable energy sources such as wind, solar and wave become more prevalent and integrated into electrical grid. Lithium-ion battery appears as quite mature for this application but its cost per mWh remains high in comparison to high temperature technology such as Zebra, which integrate low cost sodium base materials. Furthermore, as the use of large format lithium battery becomes widespread; increase demand for lithium commodity chemicals combined with geographically constrained Li mineral reserves will drive up prices. Based on the wide availability and low cost of sodium, ambient temperature sodium-based batteries have the potential for meeting large scale grid energy storage needs. In NAIADES we will demonstrate the feasibility of ambient temperature Na-ion battery from the knowledge and achievement that has been done at the laboratory scale, up to a module demonstration in a realistic application environment. Several European industrials, institutes and universities belonging to ALISTORE-ERI have decided to join their efforts to assess the Na-ion technology for stationary storage application through building a 1 kW modules system Na-ion cell which will serve as data base to demonstrate economical and public acceptance. These module prototypes will be developed to meet performances in a 1kW system in a cost-effective, sustainable and environmental-friendly manner. New energy policy will be developed to integer the Na-ion battery in the Smart Grid initiative and promote the penetration of renewable energy in the electric network.

Keywords: stationary electrical storage,smart grid,renewable energy,na ion batteries,hard carbon
Cellular substrate of abnormal network maturation in neuropsychiatric disorders (PSYCHOCELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2022-11-30
Duration (months): 78.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

The long-lasting burden of major neuropsychiatric disorders results from disruption of cognitive performance in daily life. Impairment of long-range coupling between prefrontal cortex and hippocampus represents the substrate of disease-specific mnemonic and executive deficits. While it has been hypothesized that this impairment emerges long before the first clinical symptoms, technical and ethical limitations of non-invasive investigations in high-risk infants precluded the elucidation of ontogenetic mechanisms underlying the pathophysiology of disease. In previous studies, I pioneered the investigation of long-range coupling in the immature brain by developing a multidisciplinary approach that combines electro- and optophysiology in vivo with behavior, anatomy and analysis of network dynamics. Using mouse models of disease’s etiology, we recently identified the de-coupling of prefrontal-hippocampal networks during early development as potential mechanism underlying adult circuit dysfunction. These findings represent the basis for the current proposal, which aims at understanding the cellular mechanisms accounting for abnormal network maturation in neuropsychiatric disorders. First, the role of excitation/inhibition imbalance in the neonatal prefrontal cortex for disease-specific network impairment will be assessed. Second, the synaptic organization and wiring deficits within neonatal prefrontal-hippocampal networks will be monitored. Third, the cellular substrate of abnormal hippocampal activity causing weaker prefrontal-hippocampal interactions will be ascertained. Finally, the identified cellular elements underlying early network dysfunction will be selectively manipulated to rescue the juvenile circuit function and behavioral performance. Understanding the mechanisms of network dysfunction during early development may open new therapeutic perspectives that, when initiated before the onset of clinical symptoms, may improve the devastating outcome of disease.

Keywords: neuronal networks,cognition,optogenetics,oscillations
Spin-orbit mechanism in adaptive magnetization-reversal techniques, for magnetic memory design (SMART DESIGN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 1476000.0
EU funding (EUR): 1476000.0
Participants: 2
Project status: CLOSED

Compared to existing Random Access Memories, the Magnetic RAM (MRAM) has the advantage of being non-volatile. Though the basic requirements for reading and writing a single memory element are fulfilled, the present approach based on Spin Transfer Torque (STT) suffers from an innate lack of flexibility. The solution that I propose is based on the discovery of a novel phenomenon, where instead of transferring spin angular momentum from a neighbouring layer, magnetization reversal is achieved by angular momentum transfer directly from the crystal lattice. There is a long list of advantages that this novel approach has compared to STT, but the goal of this project is to focus only on their most generic difference: flexibility. The singularity of spin-orbit torque is that the in-plane current injection geometry decouples the “read” and “write” mechanisms. The disconnection is essential, as unlike STT where the pillar shape of the magnetic trilayer sets the current path, in the case of SOT the composing elements may be shaped separately. The liberty of shaping the current distribution allows to spatially modulate the torque exerted on the local magnetization. The central goal of my project is to explore the new magnetization dynamics, specific to the Spin-Orbit Torque (SOT) geometry, and design novel magnetization switching schemes. I will begin by tackling the fundamental questions about the origin of SOT and try to control it by mastering its dependence on the layer structure. Materials with on-demand SOT will serve as playground for the testing of a broad range of magnetization reversal techniques. The most successful among them will become the building-blocks of complex magnetic objects whose switching behaviour is tightly related to their shape. To study their magnetization dynamics I plan to build a time-resolved near-field magneto-optical microscope, a unique tool for the ultimate spatial and temporal resolution.

Keywords: magnetization dynamics,spin orbit interaction,rashba effect,spin hall effect,spin transfer torque