Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hospital schools' guidelines On Physical Education (HOPE): An International, Interdisciplinary and Intersectoral Endeavour. (HOPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland,Croatia,Portugal,Brazil
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2029-06-30
Duration (months): 42.0
Total project cost (EUR): 437351.34
EU funding (EUR): 437351.34
Participants: 5
Project status: SIGNED

Built on the European priorities on digital and technological empowerment as well as equal, tolerant and fair way of life for all citizens despite their condition, the "Hospital schools' guidelines On Physical Education" (HOPE) project is a 42-month pioneering initiative aimed at developing transnational guidelines to enhance the quality of physical education for students in hospital schools, offering a unique scientific, social and economic contribution across and outside Europe. The HOPE project is anchored in a robust framework of research objectives to develop evidence- and eminence-based knowledge. This includes: i) a comprehensive desk analysis and Delphi method encompassing a systematic review, international focus groups and surveys, and ii) a solid andragogical structure construction to be applied through pilot studies of a multilingual online program for PE teachers and further developed by means of the International Judo Federation involvement. Within the project, the trainee supervision is powered by an advisory board with a mentorship approach, ensuring guidance and support from expert professionals in the fields of sport, movement, education, psychology, and health sciences within and outside academia. Involving stakeholders from mixed backgrounds and recognising the gender- and diversity-dimensions, the HOPE multifaceted research not only enhances the reliability of the guidelines but also ensures their applicability across diverse hospital school contexts and in the post-hospitalization transition. Including a 6-month non-academic placement to expand the project outcomes and foster the trainee soft and transferable skills, HOPE is sustainable, adaptable and long-running. Finally, a solid collaborative partnership and a thorough risk assessment ensure proactive identification and mitigation of potential challenges while guaranteeing the smooth execution of the project and enhancing its international, interdisciplinary and intersectoral nature.

Keywords: pedagogy,sport,health enhancing physical activity,digital empowerment,transnational guidelines,systematic review,focus groups,survey,interdisciplinary collaboration,wellbeing,online programs
NOn-VIral gene modified STEM cell therapy (NOVISTEM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Belgium
Call: Emerging Technologies in Cell and Gene therapy (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 3871287.5
EU funding (EUR): 3644418.0
Participants: 2
Project status: SIGNED

Despite the increasing awareness that cell and gene-therapy approaches have tremendous biomedical potential, their broad clinical application has been challenging due to prolonged and expensive production times and the emergence of severe immune- and gene-delivery dependent side effects. In this proposal, we aim to establish a stream-lined and high-throughput protocol for iPSC-based cell therapy by combining a novel technological platform for gene delivery with a breakthrough biological concept that will permit to manufacture functional, gene-corrected blood forming stem cells and CAR T cells. To achieve this, we will use and optimize photoporation as non-viral gene delivery method for CRISPR-mediated and site-specific gene-editing to obtain controlled CAR expression and for performing gene-correction in iPSCs. From these gene-modified iPSCs, we will generate CAR T cells and blood forming stem cells, respectively, by selectively targeting a signaling pathway that we established to be critical in human blood cell development and particularly T cell development. Following functional validation of the generated cell products, we will optimize the current protocols to increase the potential for clinical implementation and establish a high-throughput photoporation platform to generate a large number of CAR expressing iPSC lines from different ages, sex and ethnicities to demonstrate the population-wide implementation potential of our approach. This will allow to generate a bank of well-characterized, HLA-defined CAR expressing iPSC that can be used as of-the-shelf cell therapy products, thereby significantly advancing the currently implemented adaptive CAR T cell approaches by reducing the production costs and time, by selectively targeting the CAR into a well-controlled location which will prevent variability and by facilitating the production and evaluation of novel CARs for other cancer entities such as solid tumors.

Keywords: ipsc,car t,gene therapy,hsc,non viral
EQUALITY DIVERSITY AND INCLUSION FOR RESEARCH ENHANCEMENT IN BOSNIA HERZEGOVINA (EDIRE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Bosnia and Herzegovina,Italy,Spain,Ireland,France
Call: Twinning Western Balkans Special (HORIZON-WIDERA-2021-ACCESS-02, 2021)
Start date: 2022-09-01
End date: 2025-10-31
Duration (months): 38.0
Total project cost (EUR): 1486125.0
EU funding (EUR): 1486125.0
Participants: 5
Project status: SIGNED

EDIRE aims to create a networking collaboration between the University Sarajevo School of Science and Technology (SSST) and four renowned research institutions in France, Italy, Ireland and Spain, with the final aim of increasing SSST research profile, boosting its research capacity especially in the field of Equality, Diversity and Inclusion EDI. Research on EDI is almost totally unaddressed in BA, therefore EDIRE will contribute in introducing a new lines of research SSST in such strategic topics for the quality of research. These transversal research areas will be embedded in an intensive set of training and networking actions addressing more in general SSST research and management capacity. The project will rely, for the achievement of such objectives, on a variegated set of methods, such as: 1) interdisciplinarity and knowledge sharing, 2) capacity building, 3) participatory approach, 4) inclusivity and sustainability and 5) far-reaching methods for communication and engagement. The Twinning exercise will build on an appropriate set of key actions from joint training and research paths, to bilateral meetings, to short visits to dedicated conferences and summer schools, leading to new research opportunities and joint research projects in the field. The organization of networking and outreaching activities, such as conferences, dissemination events and liaison activities with similar projects, will contribute to the visibility of SSST and of the other EU partners in the field. An appropriate set of key actions will strengthen the research management and administrative skills of SSST staff and will lead to the establishment of a new Research Management Unit at SSST. Transferability and uptake of outcomes and outputs and sustainability after the project end-date will be favoured by final recommendations and guidelines to policymakers and other institutions in Widening countries.

Keywords: equality,diversity,inclusion,research enhancement,management enhancement
TErrestrial Resilience and RestorAtion Strategies for (semi) Arid and Fragile Ecosystems through a multi-actor approach (TERRASAFE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Innovation actions
Countries involved: Portugal,Netherlands,Norway,Romania,Italy,Cyprus,Sweden,Austria,United Kingdom,Belgium,Spain,Tunisia
Call: Innovations to prevent and combat desertification (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 6353621.46
EU funding (EUR): 6132886.65
Participants: 19
Project status: SIGNED

TERRASAFE is a pioneering initiative envisaging to empower local communities in southern Europe and northern Africa to successfully face the escalating challenges of desertification through the adoption of nature-based, social and technological innovations. TERRASAFE’s vision will be operationalized in 5 pilot areas that share a high vulnerability to desertification but, simultaneously, represent the 4 main types of desertification (vegetation decline, soil degradation, water scarcity, and depopulation) and strongly contrast in socio–cultural-ecological circumstances. This vision is supported by a transdisciplinary consortium, ranging from universities to SMEs commercially exploiting innovations. TERRASAFE’s vision is implemented through a multi-actor approach covering all WPs, in particular by setting up 5 partnerships in the 5 pilot areas. In a co-creation process, these partnerships will then (i) define their visions on building desertification resilience and plan their ensuing TERRASAFE work; (ii) map and analyze past and ongoing desertification, identifying hotspots; (iii) evaluate and demonstrate innovations at these hotspots, comparing them with current and traditional/organic practices; (iv) elaborate policy recommendation for the wider uptake of the TERRASAFE-certified innovations, both within and beyond the pilot areas, taking into account lessons learnt from past and ongoing policies against desertification; (v) share their TERRASAFE’s experience with the other areas, other desertification-prone communities and the general public. The consortium will support the partnerships by providing not only harmonized frameworks for each activity but also advice on adapting these frameworks to their specific needs. Finally, the SMEs will provide a wide offer of innovations that they will tailor towards the respective desertification hotspots, in close collaboration with the partnerships.

Keywords: multi actor approach,local communities,desertification resilience,depopulation,dryland degradation,innovations,policies recommendations
3D Biofabricated high-perfoRmance dna-carbon nanotube dIgital electroniCKS (3D-BRICKS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Germany,Belgium,Spain,Switzerland,Estonia
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 3570258.75
EU funding (EUR): 3570258.75
Participants: 12
Project status: SIGNED

Silicon-based CMOS technology is approaching its performance limits, but the demand for more powerful computers — driven by rapid advances in applications such as the Internet of Things, big data and artificial intelligence (AI) — remains. The discovery of various nanomaterials provides new opportunities to further develop information processing technology. Carbon nanotubes (CNTs) have, in particular, demonstrated excellent properties as a channel material in transistors. Computers based on CNT field-effect transistors (FETs) have been theoretically predicted to provide a power-performance improvement of ten times over computers based on Si-CMOS technology. However, the fabrication of high-performance CNT-nanoelectronics, and the realization of the full potential of CNTs, is highly challenging. A technological revolution would be a reliable approach to fabricate a new family of CNT-based devices that could enable aligned arrangement of the nanotubes avoiding the critical steps related to nanolithography. In particular, biofabrication using DNA-templated CNT arrays FETs has been demonstrated to further scale the alignment of CNTs within the FETs well beyond standard lithographic feasibility. 3D-BRICKS will raise this concept of integrated self-assembly CNT-nanocircuits to a completely new level by moving towards the third dimension. Indeed, the versatility of DNA nanotechnology will be the root for conceiving 3-dimensional (3D) CNT-FETs and CNT-nonvolatile memories. DNA nanotechnology will also enable to complement the CNT deposition with metallic connections, hence realizing a working circuit. This will reduce the foot-print of the final device while enhancing its efficiency, hence providing a breakthrough solution to realize the next-generation nanoelectronics. Furthermore, automated droplet-based CNT-DNA assembly, selective sorting and deposition based on assembly quality, will be an enabling technology towards upscaling production. Our approach will enable the production of scalable biotemplated electronics that can be extended to multiple applications such as metamaterials, sensors, optoelectronics, and others.

Keywords: nanoelectronics dna nanotechnology carbon nanotubes
Closed-loop deep learning in early-stage drug discovery - cloud platform for targeted protein degradation (CelerisTx - Celeris One Platform)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-07-01
End date: 2024-02-29
Duration (months): 20.0
Total project cost (EUR): 4860501.25
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Celeris Therapeutics is a deep learning company that uses innovative, in-silico methods such as geometric deep learning and graph neural networks to degrade currently undruggable targets (pathogenic proteins). The platform shall make a broad impact by addressing currently incureable diseases such as Alzheimer's, Parkinson's, and different types of cancer like breast and prostate cancer. Celeris Therapeutics' technical solution is the web application (orchestration platform) Celeris One. It consists of three modules: Hades (target ID), Xanthos (predicting biomolecular interactions and ligand design), Hephaistos (automated synthesize and validate). The addressed market is in the early-stage drug discovery and users are pharmaceutical and biotech companies with a focus on Targeted Protein Degradation. The targeted customers are med. and comp. chemists, that currently rely on docking, which is computationally intensive, slow and inaccurate compared to CelerisTx deep learning methods.
Dynamic Spatio-Temporal Modulation of Light by Phononic Architectures (Dynamo)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Germany,United Kingdom,France,Poland,Belgium
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-03-01
End date: 2026-08-31
Duration (months): 54.0
Total project cost (EUR): 2552277.5
EU funding (EUR): 2552277.5
Participants: 15
Project status: SIGNED

Imaging technologies form the basis of a vast range of products and devices and improvements would have a huge impact both scientifically and commercially. We have identified a key bottleneck, how light is modulated in the imaging system, that we can unlock to achieve a new paradigm in imaging technologies. Spatial light modulators, and similar components, operate sequentially: the light beam is shaped in different patterns but the time interval between patterns is limited by the refresh rate of the device. We will remove this limitation, thereby creating a technological breakthrough; our advance will be to send all possible patterns of the device simultaneously, and encoded in a short nanosecond pulse, creating the concept of parallel beam shaping or dynamic spatio-temporal light modulation device. In Dynamo, we will shape optical beams in two spatial dimensions plus the temporal one. The equivalent refresh rate of the dynamic pixel will start at GHz, although we are confident it will become much higher by the end of the project. To give an idea of our ambition, we compare this improvement in the time to process images with the improvement in the clock frequency of computers: the first general-purpose electronic computer, the ENIAC, had a clock frequency of 100kHz in 1945. It was not until 2000 where AMD reached 1 GHz in their computers. Processing images is broadly similar to processing data so this is indicative of the fifty-year acceleration in the realm of imaging that we will achieve. Dynamo is an ambitious and integrated project that begins by studying the fundamentals of acoustic wave scattering and ends by developing ultra-fast imaging applications in optics. The success of this pathway requires the synergy of the disciplines of physical acoustics, photonics and imaging. The outcomes from this project offer to accelerate imaging technologies and place European science and industry at the forefront of the inventions and advances that will follow.

Keywords: phononic crystals,phononic plates,photonics,disordered structures,nanomaterials,optoacoustics,imaging,spatial light modulators,compressive sensing
Rapid Microplastic Analysis by Microparticle Radars (RAMP-UP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Türkiye
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-08-01
End date: 2025-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Microplastics pollution is becoming increasingly problematic due to its involvement in a myriad of health problems and its effects on natural wildlife. Water agencies across the globe are progressively implementing screening policies for drinking water to address this issue. However, this is proving to be challenging since the existing monitoring technologies are labor intensive and time-consuming with low throughput. To address the issue, we propose a new flow-through sensor that builds upon technologies that were developed during our main ERC project. The sensor device combines two different electronic sensors that extract both the size and the dielectric permittivity of microparticles passing through the system in a rapid and high throughput manner. The dielectric permittivity is a robust parameter that can be used to identify plastics from other materials found naturally in the environment. By utilizing this difference at the single microparticle level, our new technology can be used either to eliminate non-plastic materials from samples for down-stream conventional microplastics spectroscopy, or as a stand-alone automated sensor for rapid microplastics quantification in drinking water samples. Here, we will set up a microplastics workbench to cross-validate the accuracy of our proposed technology. After validation and securing the IP rights, we will seek out drinking water samples from water boards across the globe to analyze them in our lab. This will allow us to form networks of collaborators and lead us towards providing rapid microplastics analysis as a commercial service to water regulation agencies. In addition to the potential economic opportunities, we envision that our technology will accelerate microplastics screening and play a significant role in stymieing the spread of microplastics pollution.
Single or Double? A Radical Approach to Main Group Catalysis (RadicalCAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2026-10-01
End date: 2031-09-30
Duration (months): 60.0
Total project cost (EUR): 1998761.0
EU funding (EUR): 1998761.0
Participants: 1
Project status: SIGNED

Can the use of d-block elements be circumvented in catalysis? The knowledge base of chemical transformations involving transition metal species is vast. Indeed, the versatility of transition metals has rendered them indispensable for a substantial number of transformations. Yet, the corresponding reactivity of compounds derived from the p-block elements is much less studied. However, in the last two decades, a number of advancements has inspired a renaissance in the chemistry of the p-block particularly in the realm of catalytic transformations. With commercial interest in main group catalysts stemming from reduced purification costs, potential lower toxicity, different functional group tolerances or alternative selectivity, there has been a drive to develop new p-block systems for synthesis and catalysis. In this project I aim to deepen the understanding of radical frustrated Lewis pairs, and to develop catalytic protocols for the synthesis of useful compounds. Alongside this I will develop flow and flow electrochemistry as enabling tools in main group chemistry to address current challenges in catalysis and sustainable chemistry. Overall, this work will cover both fundamental and applications-driven research, demonstrating a diversity of chemical transformations of the p-block elements as well as the use of enabling technologies including flow chemistry, electrochemistry, and electron paramagnetic resonance (EPR) spectroscopy. Collectively, the work packages (WPs) described herein will illustrate new strategies in synthesis and novel reactivity that will lead to a deeper understanding and applicability of these elements. Indeed, the discovery of new synthetic methodologies is crucial for developing novel compounds leading to new pharmaceutical leads, resulting in economic and societal benefits. The work outlined in this ERC proposal will further the resurgence of p-block chemistry providing fresh insights into both organic and main group chemistry.

Keywords: lewis acid catalysis frustrated lewis pair