Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards growth for business by flexible processing in customer-driven value chains (INSPIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Coordination and support actions
Countries involved: Spain,Italy,Belgium,Netherlands
Call: Business models for flexible and delocalised approaches for intensified processing (H2020-SPIRE-2016, 2016)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 495065.0
EU funding (EUR): 495065.0
Participants: 4
Project status: CLOSED

INSPIRE aims at increasing the competitiveness of European manufacturing which depends on producing differentiated and high added value products in an efficient and sustainable manner, with reduced production costs, increased product quality, minimised time to market and optimized strategies towards resource efficiency. The main focus of this project is the development of innovative business models creating flexible networks through the use of intensified processing that would promote more local production in Europe within the 5 years after the end of this study. The project takes an interesting and valuable approach by bringing together the (downstream) manufacturing (“Factory of the Future”) community with the (upstream) process industry (SPIRE) community, as well as regional industrial clusters (parks) to study required changes of business models in Europe, due to a.o. 1) further integration of these industries in the value chain leading to more flexible and demand driven business operation and 2) increased trends towards resource sharing and optimization across multiple process industries (e.g. through industrial symbiosis within regional contexts such as industrial parks). Special attention will also be given to how this approach would be responding to the needs of SMEs as partners in value chains. Expected outcome of this project would be the description of the current European landscape and link between intensified processing and flexibility, development of innovative business models for different sectors in general, and providing a guideline to measure the performance of such novel models under different scenarios.

Keywords: flexible processing,customer driven value chains,innovative business models,manufacturing,factories of the future,spire community,smes,scenarios and validation
PROBING EXOTIC QUANTUM HALL STATES WITH HEAT QUANTUM TRANSPORT (QUAHQ)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1499839.0
EU funding (EUR): 1499839.0
Participants: 1
Project status: SIGNED

Under high magnetic field and at low temperatures, electronic interactions in a two-dimensional electron gas give rise to exotic, strongly correlated many-body quantum Hall states. These states have been proposed for the implementation of new quantum circuits, for instance realizing topologically protected quantum computing. Although exciting, these states remain poorly understood, because the conventional experimental approach for their investigation, dc electron transport, only yields limited information. In particular, electron transport only probes the physics of the current-carrying edge channels of the quantum Hall effect propagating along the edges of the electron gas, leaving the physics of the bulk unexplored. To gain a better understanding of these exotic states and their origin, I propose a new, unconventional approach, based on heat transport measurements, which directly probes the charge-neutral, heat-carrying collective modes characterizing these interactions-induced states. I will focus on the debated ν=0 quantum Hall state of monolayer and bilayer graphene, which is thought to arise from spontaneous spin- and valley- symmetry breakings due to interactions, and on the fractional quantum Hall effect, where the competition between interaction and disorder gives rise to low-energy, heat-carrying neutral modes which have not yet been observed in graphene. Investigating the neutral modes through heat transport will address two important questions regarding these exotic new states: does ν=0 indeed arise from spontaneous symmetry breakings, and what is the origin of the low-energy neutral modes in the fractional quantum Hall effect, particularly in graphene. Furthermore, it will be possible to apply my approach to the investigation of other exotic quantum states in two-dimensions, such as the superfluid excitonic condensate in electron-hole bilayer systems.

Keywords: quantum hall effect,heat quantum transport
A CutFEM Paradigm for Surgical Guided Growth of Bone Joints (CutGrow)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Many children suffer from bone deformities, which severely hinders their ability to walk. Some children may require invasive surgical treatment, such as cutting their bones, whilst others may recover their mobility through less invasive treatments such as guided growth surgery. However, surgeons have difficulties choosing the best treatment options because there is no reliable tool to help them predict the post-operative evolution of bone joints. CutGrow aims to provide a numerical platform whereby bone growth will be predicted virtually. The platform will rely on a novel finite element technology, CutFEM, developed by the applicant, Dr. Claus, which circumvents the need for meshing complex geometries. This algorithmic concept will bestow numerical agility upon all steps of the simulation process, from acquiring patient-specific data to handling complex contact conditions between interacting bones, the latter being the domain of excellence of the host supervisor Prof. Erleben. In the first stage of CutGrow, a seamless and robust simulation pipeline in the specific context of bone joint mechanics and growth will be created. In a second stage, the simulation will be used as a basis to develop a unifying and highly versatile model for children’s bone growth, capable of easily handling a range of mathematical growth stimulus theories. Finally, we will specialize the developments to the context of guided bone growth and prove that the proposed modelling framework can reproduce clinical data gathered by MD Wong at Hvidovre Hospital. The CutGrow simulation environment has the potential to transform paediatric orthopaedic surgery, by providing researchers with an agile tool to investigate new treatment options virtually and to design new operation planning procedures based on reliable, physics based simulation technologies.

Keywords: finite element method,x fem,growth modelling,contact mechanics
Mercury Emissions Control (MEC) technology to enable thorough assessment of combustion and waste incineration plants to meet upcoming legislation directives for the reduction of mercury emissions (MEC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-07-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Mercury emissions created during industrial processes are one of the most harmful pollutants, causing neurotoxic effects in humans and animals. Upcoming changes to EU Industrial Emission Directives are set to reduce mercury levels over the coming years with a plan to eventually eliminate mercury emissions entirely. The largest emitters of mercury are our target markets coal-fired power plants, waste incineration and all combustion plants (cement, chemical industry, etc.), are required to retrofit costly solution technologies to meet limit values. But, identifying the most applicable mercury reducing solution for each individual plant is an industry challenge since there is no ‘one-size fits all’ solution due to varying fuel composition, technology mix and plant configuration at each individual plant. Building on our globally unique know-how for measuring, controlling, regulating and optimising feedstock, we have developed MEC, a unique mobile mercury testing facility that enables us to offer our clients a site specific solution with our further innovative plant technology. Our revolutionary new systems accurately measure mercury content and distribution in the flue gas duct. Subsequently, a significant reduction of the mercury content takes place using our new innovative processes and plants. Having proven TRL6, our objectives during this Horizon 2020 project are to finalise the MEC technology and prove to our target markets that MEC is a viable means of delivering an effective combined solution for efficient mercury emissions detection and reduction. We expect for MEC advancements to the SOA to enable us to meet our company objective to become a leading European player for mercury emissions detection and control. It is key for us to plan our market entry strategy carefully to ensure success is maximised. This Feasibility Study will allow us to: refine market knowledge; scope the legislative pathway; the work plan and produce a business plan.

Keywords: mercury,emissions,mercury pollution,industrial processes,combustion plants,waste incineration,plants,industrial emissions directive
Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication. (INPACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Spain,Australia,Spain,United States,Brazil,Portugal
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 1390500.0
EU funding (EUR): 850500.0
Participants: 10
Project status: CLOSED

INPACT aims at the pre-clinical development of innovative drugs and drug formulations against selected cancers (eg prostate cancer) and pathogenic bacteria (eg S. aureus). The INPACT consortium allies the expertise of both academic and industrial R&D partners that contribute with their own unique technologies to achieve new drugs that are only possible to develop in an integrative effort. Academic partners have unique knowledge and technologies on supercharged viral proteins-derived cell-penetrating peptides (eg from Dengue virus) and ultra-resistant cyclic peptides that may be transferred to the industrial partners, which in turn have specialized proprietary technologies on anticancer and/or peptide drugs’ technologies. The judicious exchange of knowledge among partners will lead to new resistant peptides for trans-barrier delivery of drugs (eg cyclic peptide-drug chimeras) and bacterial killing (both planktonic and biofilms). INPACT includes four leading academic partners (from Portugal, Spain, Australia, and Brazil) and three consolidated biotech SMEs (one from Portugal and two Spain). In addition to the R&D project itself, INPACT involves at the highest possible level a top business school in Europe (IESE, Barcelona, Spain), a consolidated media partner specialised in science communication (Ciencia Hoje, Rio de Janeiro, Brazil) and experts in international science funding from one of the top US universities (University of Stanford). The consortium will be the perfect environment for young researchers to acquire knowledge and skills in science, technology, entrepreneurship, business, and communication so they can pro-actively tailor their career path in a life-long learning perspective. This is a contribution towards the advancement of Europe through the use of research and education for societal development and economic growth.

Keywords: drug,virus,bacteria,cancer,peptide,dengue,communication,entrepreneurship
Loops and groups: Geodesics, moduli spaces, and infinite discrete groups via string topology and homological stability (Loops and groups)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 1864419.0
EU funding (EUR): 1864419.0
Participants: 1
Project status: SIGNED

This proposal lies at the intersection of algebra, topology, and geometry, with the scientific goal of answering central questions about homological stability, geodesics on manifolds, and the moduli space of Riemann surfaces. Homological stability is a subject that has seen spectacular progress in recent years, and recent work of the PI has opened up new perspectives on this field, through, among other things, associating a canonical family of spaces to any stability problem. The first two goals of the proposal are to give conditions under which this family of spaces is highly connected, and to use this to prove homological and representation stability theorems, with determination of the stable homology. Particular attention is given to Thompson-like groups, building on a recent breakthrough of the PI with Szymik. The last two goals concern geodesics and moduli spaces via string topology: The third goal seeks a geometric construction of compactified string topology, which we propose to use to address counting problems for geodesics on manifolds. Finally our fourth goal is to use compactified string topology to study the harmonic compactification itself, and give a new approach to finding families of unstable homology classes in the moduli space of Riemann surfaces. The feasibility of the last goals is demonstrated by the PIs earlier algebraic work in this direction; the proposal is to incorporate geometry in a much more fundamental way. The project combines breakthrough methods from homotopy theory with methods from algebraic, differential and geometric topology. Some of the goals are high risk, but we note that in those cases even partial results will be of significant interest. The PI has a proven track record at the international forefront of research, and as a research leader, e.g., through a previous ERC Starting Grant. The research team will consist of the PI together with 3 PhD students and 3 postdocs in total during the 5 years.

Keywords: homological stability,thompson groups,string topology,moduli space of riemann surfaces
Toward the Commercialization of a Proteolytically Resistant APPI Variant for Inhibiting Metastasis in Prostate and Pancreatic Cancer (PROT-RESIST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-11-01
End date: 2021-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Distal site tumor metastasis is the leading cause of prostate- and pancreatic-cancer-related deaths; nevertheless, standard-of-care (SoC) treatments and other targeted therapies under development are based on their activity against the primary tumors rather than on their anti-metastatic activity. There is consequently an urgent medical need for new agents targeting the metastatic process. In prostate and pancreatic cancer models, the serine protease mesotrypsin promotes tumor invasion and metastasis, making it an attractive target for therapeutic intervention. In our ERC StG project, we used directed evolution to generate a novel prototype mesotrypsin inhibitor, designated APPI-3M, which is based on the human amyloid β-protein precursor Kunitz protease inhibitor domain (APPI) scaffold. This inhibitor has picomolar affinity, enhanced binding specificity and improved proteolytic resistance to mesotrypsin and exhibits high potency in cell-based and preclinical models of prostate cancer invasion and metastasis. In this PoC proposal, we propose to perform final lead optimization (particularly decreasing body clearance) of APPI-3M towards its commercialization for clinical translation as an antimetastatic therapeutic adjuvant, with the direct involvement in the planning stage of clinicians and other key opinion leaders in the field. The feedback of these experts is expected to confirm the need to address the problem of metastatic progression and to identify potential indications and therapeutic windows for the use of APPI-3M as a neoadjuvant in prostate and pancreatic cancers. This input will be translated into feasible preclinical studies to demonstrate the contribution of APPI-3M therapy to currently ongoing SoC protocols for prostate and pancreatic cancers. In parallel, we will carry out the in-depth market and IP analyses needed for the commercialization of the engineered protein for therapeutic applications.

Keywords: protein engineering,drug design,stability engineering,proteolytic enzymes,antagonist,directed evolution,metastasis,cancer therapy
My Science - Our Science (Our Science)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Iceland
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-12-31
Duration (months): 20.0
Total project cost (EUR): 262505.0
EU funding (EUR): 175000.0
Participants: 1
Project status: CLOSED

The impact of researchers’ work on society and citizens has never been more apparent than now. At the same time, there is an impending risk of loosing citizens’ trust in science, due to incresed amount of misinformation about science and research. Therefore, it is important to promote the key role that researchers have for the development and growth of our societies in a national and international context, and for keeping the public informed about critical challenges and scientific discoveries that have an impact on our daily lives. In Iceland, science has a crucial role to play in a society that relies to a great extent on nature and responsible use of natural resources, from renewable energy and sustainable blue growth to the societal and cultural implications of living in coastal communites. In order to ensure and facilitate interaction with the public and society at large, the project "My Science – Our Science" aims to organise European Researchers Night in Iceland with the aim to invite researchers to engage with the public to communicate their work, their passion and their findings in order to increase the awareness of research and innovation activities. The objective is to enhance a positive public perception of researchers by facilitiating an open and active dialogue between researchers and citizens of all ages, especially focusing on children and young people that could consider a research career. In addition to higlighting the importance of researchers’ work, the initiative provides a rare opportunity for researchers to communicate directly with the public at all ages and even to involve citizens in the road to scientific discoveries, thus contributing to the transparency of their work and enhancing the attractiveness of scientific careers, which is instrumental in encouraging young people to embark on a career in research.

Keywords: researchers,public recognition,researchers night,science communication,public engagment,citizens science,science career
BIOfilm management and CLEANing by leveraging fundamental understanding of biological, chemical and physical combined approaches (BIOCLEAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Spain,Germany,Italy,Belgium,Belgium,Belgium,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-10-01
End date: 2020-09-30
Duration (months): 48.0
Total project cost (EUR): 3908202.48
EU funding (EUR): 3908202.48
Participants: 12
Project status: CLOSED

BIOCLEAN addresses the urgent need to create a sustainable training network across academia, industry and the healthcare sector which will fill the gap in Europe and beyond to produce highly skilled multi-disciplinary young scientists competent in chemistry, engineering and experimental wet lab biology. BIOCLEAN will deliver this network of young scientists who can apply their proven skill sets gained during the project life time to solve industrial and healthcare sector real life biofilm management challenges.

Keywords: biofilm,surface,characterisation