Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Time resolved X-ray probing of Matter under Extreme conditions (TeX-MEx)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1996316.0
EU funding (EUR): 1996316.0
Participants: 1
Project status: CLOSED

The unique properties of a new type of X-ray source produced by a compact laser-plasma accelerator will be used to probe the ultra-fast dynamics of the electronic structure of matter under extreme conditions. The TeX-MEx project will study: 1) hot dense matter, such as that found at the centre of the Sun; 2) warm dense matter such as that found at the centre of Jupiter and 3) photo-ionized plasmas far from equilibrium such as is found in the exotic environment of an accretion disk surrounding a black hole. These extreme conditions will be created in the laboratory using 1) direct laser heating, 2) proton heating and laser driven shock heating and 3) intense X-ray pumping using the betatron source itself and the extraordinary X-ray fluxes available with a free electron laser. Using the unique combination of a few-femtosecond duration and broad spectral coverage that the X-rays produced by a laser wakefield accelerator possess, the TeX-MEx project will explore new physics in each of these regimes. For example we will be able to directly measure the rates of ionization of hot dense matter for the first time; we will observe the onset of ion motion in warm dense matter and how this affects the electron energy levels; we will make the first observations of non-collisional photo-ionized plasmas. These will allow us to accurately test and develop models used to describe matter under extreme conditions in the laboratory and in astrophysics. This integrated program of innovative experiments and new approaches to modeling will open up a new field of femtosecond time-resolved absorption spectroscopy of matter under extreme conditions and will drastically improve our understanding of how matter behaves throughout our Universe. It will, for the first time, bring to our laboratories on Earth the ability to probe some of Nature's most violent processes, to date only hinted at in data from a new generation of astronomical instruments.

Keywords: laser plasma accelerators,matter in extreme conditions,ultra fast x rays
Functional analysis of the kinome and phosphatome as determinants of integrin phosphorylation in cancer (INTEGRIN REGULATION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 190680.96
EU funding (EUR): 190680.96
Participants: 1
Project status: CLOSED

Integrins are key signalling molecules that mediate the complex relationship between cancer cells and their associated ECM; as such they have been implicated in every step of cancer progression. Their cytoplasmic domains are essential hubs for protein-protein interactions, where phosphorylation of key sites modulates integrin activity and oncogenic signalling. However, the regulators of integrin phosphorylation remain elusive. The proposed work will address the role of integrin beta1 in breast cancer epithelial and stromal cells, where increased expression and/or activity are correlated with poorer survival. To this end, the fellow has developed a Förster resonance energy transfer (FRET) biosensor for integrin beta1 phosphorylation, which will be applied in a kinome-/phosphatome-wide screen for regulatory kinases and/or phosphatases. This screening will be completmented with global mass spectrometry to identify phosphorylation-sensitive interactions with the integrin beta1 cytoplasmic domain. Out of these screens, the fellow will validate the identified kinases and/or phosphatases using three-dimensional functional assays, as well as standard biochemical approaches, in conjunction with live super-resolution imaging to pinpoint the subcellular localization of the interacting complex. The clinical relevance of the identified kinases and/or phosphatases will then be evaluated with immunohistochemistry staining of large breast cancer cohorts, along with functional validation using patient material from clinical collaborators. These aspects will provide an essential link from the mechanistic insights to improving patient outcomes from this work.

Keywords: fret,biosensors,integrins,metastasis,cancer
An innovative process to extend commercial bioprosthetic heart valves lifespan. (FACTA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Heart valve disease is one of the main causes of morbidity and mortality worldwide. In 2017 around 400.000 patients underwent heart valve replacement. Mechanical (MHVs) and Bioprosthetic (BHVs) Heart Valves are the most used substitutes. However, the former have problems related to their thrombogenicity, the latter durability issues that limit their use. Recently an alarming correlation between the presence of the alpha-Gal epitope and a premature BHVs degeneracy was reported. BioCompatibility Innovation (BCI), an Italian biotechnology Startup, aims to bring on the market FACTA: an innovative treatment for inactivating the alpha-Gal xenoantigens in biological tissues that can be used to manufacture BHVs substitutes. FACTA has been patented and its reliability and efficacy have been validated by extensive in-vitro investigations that confirm a significant decrease in calcification propensity (over 85%) and a better resistance of the treated tissue, compared to the current chemical treatments of BHVs manufacturers. Currently a pilot study is ongoing, involving the implant of commercial BHVs treated with the FACTA protocol in swine with a one-month short permanence time (assessment of the acute toxicity and immunological tolerability of the FACTA treatment). BCI will evaluate a more in-depth validation of maintaining the physiological/structural efficiency of FACTA treated BHVs in an animal model implant for the expected 6-month duration. The global BHVs market is constantly growing: 11.71% CAGR between 2013 and 2022. FACTA can be perfectly integrated into the production flow of BHV manufacturers, without requiring any change in the supply chain. BCI raised about 850.000 € by founders and grants. FACTA received the "Seal of Excellence" by European Commission in June 2018. The total financial requirement amounts to about 2.7 M€, mainly for clinical validation and product industrialisation over 2 years, with a NPV of over 8.5M€ and an IRR of 58%.

Keywords: bioprosthetic heart valves,biocompatibility,alpha gal,dystrophic calcification
Mid-infrared laser system for high-throughput bioprinting by laser-induced forward-transfer (MIDLIFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The goal of this Fellowship is the development of a novel mid-infrared laser system for high-throughput bioprinting by laser-induced forward-transfer (LIFT). The Fellow will develop a high repetition-rate, high-power, nanosecond laser system emitting at exactly 2.9 µm (the peak absorption wavelength of liquid water). The strong absorption of the mid-infrared laser output in biomaterials will be utilised for the demonstration of a new bioprinting technique: mid-infrared LIFT of biomaterials. It will overcome the main drawback of conventional biomaterial LIFT, which is the reliance on additional absorber layers and contamination of printed materials with metallic debris. Mid-infrared LIFT will enable high-throughput (10k droplets/s), high-resolution (picolitre droplets) 3D-printing of biomaterials without metallic contamination and will be a highly promising platform for tissue fabrication. The mid-infrared laser system will be realised with a gain-switched quantum-cascade diode laser and multiple Er-doped fluoride-fibre amplifier stages. The laser system will be designed to provide 25 ns pulse durations, 10-30 µJ pulse energies, 100 kHz repetition rate, and laser emission at 2.9 µm wavelength. This laser system will be integrated into an existing LIFT setup and used for the first demonstration of mid-infrared LIFT bioprinting. The Fellow is an early-stage postdoc, who has resumed his research career after a 5-year period working in industry. He is an expert in fibre laser development and will be trained in quantum-cascade-lasers, gain-switched diode lasers, LIFT, and bioprinting. The complementary training will include communication and dissemination of research results, commercialisation of research output, and acquisition of research and innovation project funding. The Fellowship will enable the Fellow to establish a unique scientific profile, build a research network, and reach professional maturity.

Keywords: bioprinting,mid infrared laser,fiber laser,lift
Metabolomic analysis for the forensic detection of drugs of abuse in performance and food producing animals (MET-A-FOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 819863.64
EU funding (EUR): 819863.64
Participants: 2
Project status: CLOSED

Forensic detection of the illicit use of drugs in performance and food-producing animals is experiencing critical shifts in paradigms with a growing threat in the form of new compounds emerging from human drug development and clinical applications. The MET-A-FOR project will be the first European training platform solely focussed on the development and practical advancement of animal forensic testing based on new concepts in metabolomics. This EID programme will train 3 early stage researchers (ESRs) to be creative, problem-solving and entrepreneurial European scientists with skills in high level interdisciplinary and intersectoral analytical techniques who can aid the translation of emerging discoveries from the academic sector to the commercial sector. The MET-A-FOR project will through the training and development of ESR Fellows and their completion of defined interconnecting PhD projects, bridge the knowledge gaps surrounding the novel concept of metabolomic profiling evident between fundamental researchers in academia (QUB) who have been developing such methods, and non-academic commercial end-users (IDLS) who recognise the necessity and opportunity to apply these methods as diagnostic services. The training of researchers who can utilise these novel innovative analytical tools to increase analysis speeds and sample screening throughput will be essential for providing continuing confidence in monitoring controls and regulations and maintaining animal welfare standards within Europe. ESR Fellows graduating from the MET-A-FOR programme will be uniquely situated to lead, innovate, and collaborate on future technological innovation in the field of analytical monitoring and forensic testing of performance and food producing animals as the challenges in this area increase.

Keywords: metabolomics,forensic testing,drugs of abuse,performance and food producing animals,bovine,equine,mass spectrometry,animal welfare,food safety
Developing Computer Vision and Artificial Intelligence for best-quality and cost-effective live sports production and distribution (OZeye)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 3419165.0
EU funding (EUR): 2393415.5
Participants: 1
Project status: CLOSED

OZ Sports has pioneered a production and broadcasting platform called OZeye, by using cutting-edge software technologies to remotely control camera robotics, and to enable unmanned production of football games to convert them into multi-formatted video streams for various platforms. Our automated solution results in 90% cost savings while providing 4K/UHD video quality that exceeds state-of-the-art. Our broadcasting ecosystem incorporates an experience-rich environment, where football fans connect using their mobile devices. This experience-rich ecosystem will generate fan engagement and adherence to the platform, powered by Augmented Reality technology to recreate a realistic atmosphere of attending a live football game. Today’s production and broadcasting solutions are a perfect fit for the best sponsored and monied football leagues and clubs of Europe - less than 1% off all the football played on the continent. This leaves at least 11,900 European clubs without an opportunity to grow their fan base and earn revenues to auto fund their development. OZeye gives these local clubs the means to produce and broadcast their football matches to a worldwide audience. Our broadcasting platform opens the doors for any fan anywhere to watch their team at their leisure and convenience for the first time ever. Recently, we have seen the rise of digital broadcasters, though they still target the same segment of footballing leagues as the traditional linear TV networks had done before them for the past decades. If some of them incorporate automation in their production, they still do not provide a better-quality result for the viewing public, which we do, by addressing the whole value chain is what makes OZeye different. By the fourth commercialization year, we expect to install OZeye at 907 venues, which translate into 60+ leagues, generate a revenue of 84,436,000€ and create 138 jobs position to thrive in sports media and continue disrupting the sector.

Keywords: computer vision,convolutional neural network,player tracking media,and communications
Simultaneous Localization and Mapping for Augmented Reality (SLAM4AR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-10-01
End date: 2021-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The PoC Project SLAM4AR is focused on developing technological foundations for advanced augmented reality (AR) applications on smartphones. According to a recent study of Hampleton & Partners, the market value for AR applications is expected to break the $170 billion barrier by 2022. And a significant share of this market value will come from smartphone applications. In the PoC project SLAM4AR, we will build up on state-of-the-art algorithms for visual Simultaneous Localization and Mapping (SLAM) that we developed in the ERC CoG “3D Reloaded”. These algorithms allow one to recover the motion of a camera and a 3D reconstruction of the observed environment at unprecedented precision, robustness and large-scale capability (among existing real-time capable algorithms). We will reformulate and streamline these algorithms so that they can run on smartphones. They will leverage the smartphone’s camera and inertial sensor in order to compute in real-time both the location of the phone and a 3D map of the environment. In several AR applications, we will demonstrate that our algorithms with their superior precision and robustness serve as a key enabler for advanced AR technology. For example, we can perform object insertion (beyond Pokemon Go) in a way that dynamic objects interact more naturally and faithfully with a complex 3D environment – they accurately sit on chairs or tables, or they convincingly roll down slopes, etc. This will enable numerous AR applications such as teaching medical students about the 3D location of bones and inner organs, training novice car mechanics in the inner structures of a motor. Or navigating tourists to a desired location in a museum or a church. There is a rapidly growing market for AR applications on phones and we are convinced that our smartphone-based visual SLAM technology will serve as a key enabler.

Keywords: computer vision,augmented reality,smartphone applications,visual slam,3d reconstruction
Bridging the treatment gap for mild and moderate anxiety and depression across EU (Mind-Gap)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Each year, 25% of the EU population suffer from depression or anxiety, with higher rates for women than men. The cost of mood disorders and anxiety in the EU is about €170 billion per year. In most of the EU countries, patients with mild and moderate anxiety and depression only get access to specialised treatment from mental health professionals when the illness become severe. In the future, the society will have major problems in providing good healthcare if we are not able prevent more: between 1990-2013 the number of people suffering from depression and/or anxiety increased by nearly 50%. Experts emphasize that Internet-assisted treatments based on Cognitive Behavioural Therapy (ICBTs) have a great potential to improve care for mental disorders, but current solutions are having a slow adoption by health providers, mental health professionals and patients because they are very generic, do not provide controls to guarantee medical effectiveness and/or have not been designed to be used by health providers. Explorable AS has developed the unique ICBT marketplace specially designed to be directly used by health providers. It includes an authoring tool so that practitioners at these health providers can easily create their owned ICBTs by implementing engaging technologies and gamified concepts. ICBTs will also be available to other practitioners working at other health providers. Patients only get access to ICBTs in our marketplace under the prescription of general or mental health practitioners: in that way we guarantee that patients get ICBTs with proven evidence-based therapies or best-practice methods, and they get access to specialised treatment designed by mental health professionals from the onset of their illness. The overall objective of Mind-Gap Phase 1 is to carry out a feasibility study to verify the technological, practical and economic viability of scaling up our platform to other EU countries (market replication).

Keywords: anxiety,depression,icbt,internet assisted treatments based on cognitive behavioural therapy,marketplace,mental health,practitioners,elearning,gamification,e mental health
Hydrogen Storage In European Subsurface (HyStorIES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Austria,Estonia,Germany,Austria,Germany,Spain,Spain,Italy,Germany,Türkiye,Croatia,Norway,Belgium,Greece,Poland,Poland,Romania,Slovenia,France,France,Czechia,Portugal,Denmark,United Kingdom
Call: Underground storage of renewable hydrogen in depleted gas fields and other geological stores (H2020-JTI-FCH-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 2499911.75
EU funding (EUR): 2499911.75
Participants: 25
Project status: SIGNED

Renewable hydrogen combined with large scale underground storage enables transportation of energy through time, balancing out the impacts of variable renewable energy production. While storing pure hydrogen in salt caverns has been practiced since the 70s in Europe, it has never been carried out anywhere in depleted fields or aquifers. Technical developments are needed to validate these two solutions. As subsurface technical feasibility studies for a future hydrogen storage in depleted field or aquifer will be site-specific, as for other geology related activities, HyStories will provide developments applicable to a wide range of possible future sites: the addition of H2-storage relevant characteristics in reservoir databases at European scale; reservoir and geochemical modelling for cases representative of European subsurface, and tests of this representativeness by comparing it with results obtained with real storage sites models; and lastly an extensive sampling and microbiological lab experiment programme to cover a variety of possible conditions. Complementarily, techno-economic feasibility studies will provide insights into underground hydrogen storage for decision makers in government and industry. Modelling of the European energy system will first define the demand for hydrogen storage. Environmental and Societal impact studies will be developed. For a given location and hydrogen storage demand, a high-level cost assessment for development of each of the competing geological storage options at that location will be estimated, and the sites will be ranked based on techno-economic criteria developed within the project. Finally, several case studies will enable consideration of the implementation of potential projects, notably by considering their economic interest. This will provide substantial insight into the suitability for implementing such storage across EU and enable the proposition of an implementation plan.

Keywords: depleted field,aquifer,underground storage,reservoir engineering,geochemistry,microbiology,corrosion,energy modelling,social impact,environmental impact