Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated innovative pilot system for Critical Raw Materials recovery from mines wastes in a circular economy context (RAWMINA)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Germany,Spain,Ireland,Ireland,Finland,Greece,France,Czechia,Chile,United Kingdom
Call: Raw materials innovation for the circular economy: sustainable processing, reuse, recycling and recovery schemes (H2020-LCCI-2020-EASME-twostage, 2020)
Start date: 2021-05-01
End date: 2024-10-31
Duration (months): 42.0
Total project cost (EUR): 10857402.68
EU funding (EUR): 9146967.26
Participants: 20
Project status: SIGNED

RAWMINA will develop and demonstrate an innovative pilot system for the clean and sustainable production of non-energy, non-agricultural raw materials (RMs) in the EU from Mine Waste (MW) resources. RAWMINA will implement and standardize an innovative energy, water- and cost-effective continuous pilot process for producing RMs. It will integrate novel bio-leaching and nano-based materials for Sb, Co, Ge and W selective recovery from MW from “unexploited/underexploited metal containing materials”. RAWMINA will improve EU competitiveness and create added value in RMs processing, refining and equipment manufacturing by developing a new circular business model as an alternative to traditional linear mining economy. RAWMINA will integrate different technologies that will be demonstrated (TRL7) with MW of diverse geological compositions from EU and non-EU mines demonstrating flexibility in processing of the innovative pilot system. The project will perform a techno-economic and sustainability assessment throughout the entire life cycle considering health, safety, socio-economic and environmental impacts; maximizing water/energy efficiency and waste/wastewater reduction. IP, exploitation and business plans will be developed ensuring market penetration, technology export and first exploitation plan. RAWMINA will transform MW into a resource, enabling marketable products recovery to be used in batteries, flame retardants, optical fibers and industrial tools. The project will create a CRM Recovery Helix to maximise clustering and will interact with local communities to gain EU citizens trust. It will increase resource efficiency and sustainability of EU industry, contributing to decrease EU CRM import dependency. Apart from sheltering the EU from possible shortages in CRM supply, the project will contribute to reduce production costs and environmental impacts, contributing to the objectives of the European Innovation Partnership on RMs.

Keywords: crms sb,bioleaching,nanofibrous composites,magnetic separation,thermodesorption,electrochemistry,water energy efficiency,waste,wastewater,health,safety,citizen acceptanceandtrust
High-Performance Standardised System for Mass Production of Premium Freshwater Fish (SilGen)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Austria,Germany,Hungary,Slovenia,Hungary
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 2553812.5
EU funding (EUR): 1932467.5
Participants: 5
Project status: CLOSED

There is a large and constantly growing consumer demand for fish in the EU and worldwide, yet natural waters are on the edge of overfishing and capture fisheries cannot satisfy market need. Aquaculture production is the only way to go, but EU is characterised by a fragmented approach and is thus not able to compete well with global competitors, covering more than half of its consumption from imports. SilGen offers a complete system of highly efficient aquaculture for mass production of premium quality fish that is guaranteed free of contaminants. The technology is highly sustainable, can be operated under any geographical and climatic conditions, and offers 200% productivity vs traditional methods. SilGen builds on the novel opportunity offered by the comprehensive package of a newly domesticated predatory species of the native European catfish, scientifically formulated feed, and an elaborate production technology that has been perfected over a decade, now ready for deployment. However, marketing a complex novel package is a bold, disruptive step, translating to risk for initial adopters. Therefore 3 demonstrator farms will be piloted, establishing technology reference, market replication, and commercial bridgehead position. The real-life piloting will feature tech standardisation, operational protocols for different environmental conditions, business management, advanced feed formulation and species optimisation, as well as marketing and commercial preparatory actions. SilGen will be commercialised under a franchise brand, ensuring investment-light fast growth and strong scalability, to be executed by a joint venture of consortium members in ‘SilGen International’. Beyond the economic gains and global perspective, the transformative technology has the power to resolve structural limits of the European fish supply sector and drive consumer habits towards high quality, healthy, local produce, alleviating EU reliance on imports and environmental footprint.

Keywords: premium fish,safe food,standardized mass production,native european brand,franchise,piloting,market replication,sustainability
Conditions for the emergence of evolution during abiogenesis (AbioEvo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Abiogenesis, the transition from non-living to living matter, is at the core of the origin of life question. However, the dynamical processes underlying abiogenesis remain unknown. The AbioEvo project aims to test the hypothesis that RNA-catalysed RNA recombination, if coupled with template-based mechanisms, provides a gradual route for the emergence of evolution by natural selection, starting from collective autocatalysis, toward template-based replication. Indeed, recombination allows both self-reproduction and shuffling of other sequences, thus, once combined with templating, provides the basic ingredients of reproduction, heredity and variation required for Darwinian evolution. The project decomposes the problem into five steps: (WP1) the study of molecular-level mechanisms to generate and stabilize novel sequences by recombination and templating; (WP2) collective dynamics integrating these mechanisms into the properties of reproduction with heredity, variation, and selection, in order to establish proof-of-concepts of evolutionary modes; (WP3) viability thresholds of recombination-based replicators from increasingly random substrates; (WP4) conditions for open-ended evolution toward template-based replication; (WP5) experimentally informed theoretical estimates of the probability of the proposed evolutionary transitions. The project would provide first demonstrations of evolution by natural selection in a purely chemical system, gradual and experimentally accessible paths from oligomers to template-based replication, and a method to evaluate prebiotic plausibility from sequence-to-function relationships, kinetics and evolutionary dynamics.

Keywords: origin of life,rna world,microfluidics,recombination
Surviving salinity: How do plants sense Na+? (Sense2SurviveSalt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1999843.0
EU funding (EUR): 1999843.0
Participants: 1
Project status: SIGNED

A major gap in our knowledge of how plants respond to soil salinity is their initial perception of sodium (Na+) ions. Salt is detrimental to plants and soil salinization is an increasing threat to global food security; 6% of the world’s total land area and 20% of irrigated land is affected by salinity. I recently discovered Na+-specific root growth responses of plants and will now exploit these to identify the elusive sodium sensing mechanism of plants. I will use an innovative approach combining genome-wide genetic screens in the model plant Arabidopsis thaliana with dedicated biochemical assays. I will identify candidate Na+-sensor genes through a natural genetic variation screen for the Na+-specific inhibition bending of the root in response to gravity (WP1). In parallel, I will follow a chemical genomics approach to find novel compounds that impair Na+ sensing, and their target proteins in plants (WP2). Subsequent complementary in silico and biochemical approaches will characterize Na+-affinity of the candidates (WP3). Selected putative Na+ sensors will be characterized in planta, by studying their localization, activity, their interactors, and by salt response phenotyping of mutants (WP4). Finally, mutant varieties of sensors will be introduced in the economically relevant crop plant tomato, to provide proof-of-concept for improving salt tolerance by modulating sensor function and implementation in crop improvement programs (WP5). The impact of elucidation of plant Na+ sensing will be monumental; it will reveal how plant responses to salinity stress are driven, and ultimately what is required to cope with salinity. In addition, it will open up new applied directions for agriculture, where improved sodium sensing modules will be used to allow crop growth on marginal, saline soils.

Keywords: plant salt tolerance,natural variation,tomato,arabidopsis,salinity stress,sodium na perception,halotropism
Receptor signalling in space and time - Gaining high-resolution information of the temporal and spatial control of G protein-coupled receptor signalling. (MCANALSMSCA2015)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: TERMINATED

G protein-coupled receptors (GPCRs) are the largest family of cell surface signal transducing proteins encoded by the human genome. They allow the cell to respond to diverse array of extracellular signals, control most (patho)physiological processes, and are currently the therapeutic target of over 30% of marketed drugs. However, GPCR drug discovery is still characterised by a very high attrition rate, which reflects our inadequate understanding of the complex mechanisms of GPCR signalling and regulation. Up until recently, understanding of GPCR function was obtained from snapshots of receptors at different points in time and a major limitation for the study of GPCRs has been the inability to assess receptor activation and subsequent signalling events with high temporal (duration and frequency) or spatial (location) resolution. However, in the recent years there has been an explosion of biophysical and imaging approaches that will allow greater temporal and spatial resolution of receptor function than ever before. In this project we will measure ligand binding, receptor conformational changes, G protein activation, recruitment of regulatory proteins and receptor trafficking in real time and in live cells. We will therefore obtain detailed mechanistic understanding of the dynamics of GPCR activity in health and in disease that will reveal novel intervention points for future, more effective receptor-based therapies. This proposal combines my expertise in the study of GPCR interacting proteins and their role in receptor signalling and trafficking with the expertise of the Host Institution in the application of state-of-the-art imaging and biophysical approaches to study of this receptor family. As such, this project will not only broaden my research and technical skills in GPCR visualization, but it will also result in the establishment of a unique technological platform for the study of the dynamics of GPCR function within the Host Institution.

Keywords: pharmacology,membrane receptors,cell biology,molecular biology
Study of the interaction between metabolic stress and a specific genetic background on the contribution of sporadic Alzheimer's Disease (T2DM and AD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Different from the familial forms, late onset Alzheimer’s disease (LOAD) is not the consequence of a single cause: neither aging, nor genetic polymorphisms nor an environmental disturbance do, per se, suffice to produce this disease. It is currently thought that instead disease is the consequence of an interaction of all the above circumstances. With that perception in mind, I here propose to study i) the effect of type 2 diabetes mellitus (T2DM), a metabolic disturbance strongly associated with propensity to LOAD, on the appearance of AD-associated features (biochemical, electrophysiological and behavioral) ii) in the brains of aged mice iii) bearing a genetic insufficiency in either the gene SORL1 or in CD2AP, both of which have been linked to higher risk of late onset AD in recent familial genome wide association studies (GWAS). Once the phenotypic analysis is completed, I will perform genome wide epigenetic analysis of T2DM on specific neuronal populations of wild type and the genetically deficient mice. All in all, my studies should help to determine the mechanisms by which environment, age and disease-predisposing genetic weaknesses link together to produce this disease.

Keywords: type 2 diabetes mellitus,metabolic stress
High Pressure Processing (HPP) equipment for large beverage productions (BEVSTREAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2015, 2015)
Start date: 2016-03-01
End date: 2018-09-30
Duration (months): 31.0
Total project cost (EUR): 3389683.75
EU funding (EUR): 2372778.0
Participants: 1
Project status: CLOSED

Hiperbaric is a Spanish SME leader in the designing, manufacturing and commercialization of High Pressure Processing (HPP) machines on an industrial scale. HPP is an innovative processing technology for many types of foods (meat, seafood, vegetables, fruit products…) with an important growing potential over the traditional techniques such as thermal pasteurization. This non-thermal process, also called Cold Pressure Technology, inactivates microorganisms thanks to pressures up to 600 MPa (6000 bar or 87,000 psi), increasing food safety and shelf-life, keeping flavor, nutrients and product freshness. Phase 1 of Bevstream project has consisted in the elaboration of a feasibility report regarding a new business line to be developed by Hiperbaric for the commercialization of highly productive HPP machines. This will boost the penetration of HPP technology in the global beverage market, which requires very high productivity and better performances. Hiperbaric’s HPP innovation will mean increasing productivity, lowering processing costs and energy consumption as well as facilitating the installation and integration of HPP technology within beverage production lines. The positive results, obtained in the above mentioned Phase 1, have led Hiperbaric to apply for SME Instrument Phase 2 in order to take advantage of the great business opportunity detected. The launching of the business is scheduled for mid-2018, after the twenty-four months for the Phase 2 implementation, when the new product will be ready to be commercialized. The sales of a new range of equipment will significantly increase Hiperbaric’s turnover, benefit and staff, strengthening its global leadership and probably becoming the main business line of the company before 2025.

Keywords: high pressure processing,beverages,juices,equipment
A European Training Network to Combat Bone Pain (BonePainII)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Sweden,Sweden,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,Denmark,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 4291665.12
EU funding (EUR): 4291665.12
Participants: 12
Project status: CLOSED

In Europe 20 - 30% of adults are affected at any one time by musculoskeletal pain such as arthritic pain, lower back pain, pain from osteoporotic fractures and bone metastasis, and also most rare bone diseases are very painful. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is yet available. Therefore, there is a strong need to train highly skilled researchers within bone pain and thereby make the foundation for improved therapies. In this proposal we bring together 3 industrial beneficiaries, 8 academic beneficiaries, and one industrial partner all committed to train a new generation of 15 creative, entrepreneurial and innovative early stages researchers in bone pain research and transferable skills. The early stages researchers will train with some of the foremost neuroscientists and bone researchers in academia and industry across Europe. The BonePainII training network will provide the early stage researchers with expertise that will enable them to gain high level employment both in academia and industry. In a multidisciplinary, intersectoral and integrated project we will develop advanced 3D microfluidic in vitro platforms and high throughput techniques to investigate bone-neuron interactions; validate and investigate novel in vivo models of bone pain including a rare bone disease; and using cutting-edge technologies to identify key mechanisms underlying bone pain in osteoarthritis, rheumatoid arthritis, and cancer-induced bone pain.

Keywords: bone,pain,animal models,skeletal diseases
Double network hydrogels for topical drug delivery applications (Net2Gel)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: CLOSED

Polymer hydrogels contain over 90% water and are very useful materials in many biomedical areas such as contact lenses, drug delivery, wound healing, among others. However, many hydrogels are mechanically underperforming in that they are either too weak or too brittle. Double network hydrogels have shown significant promise to overcome this issue and mechanically strong or stretchable, elastic double network hydrogels have been reported. The overall aim of this project is to develop a new class of stretchable biocompatible double network hydrogels based on polypeptides as patches for transdermal drug delivery. The project will develop novel chemistry to achieve materials with enhanced properties validated for a drug delivey application by a multidisciplinary approach combining expertise in polymer chemistry, material science, drug delivery and biomaterial science. The project will foster new collaboration opportunities between research groups from different scientific fields. The high-level science is complemented by bespoke training activities, which will significantly advance the career opportunities of the applicant. A particular feasture of the project is the proposed development of a hydrogel school experiment in collaboration with the teachers-in-residence programme of the Irish Centre for Medical Device (CURAM) to foster scientific interest, motivation and encouragement for pupils in schools located in disadvantaged communities. Moreover, commercial exploitation of the scientific findings and developments will be explored.

Keywords: polypeptides,hydrogels,interpenetrating networks,mechanical properties,transdermal drug delivery