Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIOlogical therapy CYCLEs towards tailored, needs-driven, safer and cost-effective management of Crohn’s disease (BIOCYCLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Israel,Belgium,Belgium,Sweden,Sweden,France,United States,United Kingdom,United Kingdom
Call: New therapies for chronic non-communicable diseases (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-04-01
End date: 2022-12-31
Duration (months): 93.0
Total project cost (EUR): 5962096.88
EU funding (EUR): 5962096.88
Participants: 17
Project status: SIGNED

The BIOCYCLE Project proposes to test and critically assess the benefits and risks of an innovative regimen for improving the treatment of Crohn’s disease (CD), a chronic immune-mediated inflammatory disease affecting the gastro-intestinal tract of an increasing number of patients. Currently, the combination of anti-TNFα monoclonal antibodies and immunosuppressants used without interruption is the gold standard for treating CD. However, long treatments are needed which raise safety concerns and costs. For maintaining the same level of efficacy while reducing risks and costs, the idea of BIOCYCLE is to use a regimen based on "Treatment Cycles" characterized by alternating periods where both drugs are administrated and periods where only either anti-TNFα or immunosuppressant is used. The central part of the Project will be a large-scale controlled multi-centric clinical study including 300 patients in EU and USA to test the feasibility of shifting from drugs combination used without interruption (control) to Treatment Cycles (experimental arms). Primary and secondary objectives of the clinical study have already been validated for generating the best qualitative and quantitative data on clinical outcomes, predictors of disease evolution and costs. In parallel, the Project will calculate costs-of-illness associated with the different regimens and will perform surveys among patients, caregivers and healthcare systems representatives to assess their readiness to include/support Treatment Cycles in the clinical practice. This will be the basis of a critical appraisal of Treatment Cycles and guidelines for helping caregivers to decide which treatment regimen best fits the specific needs of their patient. If proven, the benefits of Treatment Cycles for treating CD will be discussed with key-opinion leaders involved in the treatment of other immune-mediated inflammatory chronic diseases to support the evolution of disease-driven treatments towards needs-driven treatments.

Keywords: crohn s disease,cycles,innovative treatment strategy,anti tnf,immunosuppressants,safety,cost effective,survey,quality of life,relapse,maintenance therapy,imid
West Africa's Role in Human Evolution (aWARE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Recent evidence indicates that the roots of our species, Homo sapiens, do not trace back to a single population, but to morphologically diverse group living over an extensive geographic area from Morocco to South Africa. The range of environments and regions in Africa that played a role in shaping our species is therefore rapidly emerging as central to unravelling human origins. However, thanks to the lack of fieldwork in many regions of Africa, these important parameters are not well understood. The aWARE project will therefore undertake a timely investigation into the role of Africa’s western forests, and their neighbouring ecozones, in modern human origins. Genetic and fossil studies have associated poorly known West Africa with complex evolutionary processes thought to have played a key role in shaping our species. Such processes include admixture between our species and late-surviving archaic humans, and long-term isolation of H. sapiens populations in forested zones. Significantly, research in West Africa by the applicant has also identified a unique late persistence of stone tool technology typical of much older periods, while at the same time demonstrating that human populations were present in currently forested regions close to the time of H. sapiens speciation. aWARE builds on this pilot work and sets forth a series of explicit, testable hypotheses to explore the time depth and environmental context of human populations in West Africa as a window into our pan-African origins. To adequately address these hypotheses, an interdisciplinary approach is taken, combining information from archaeology and palaeoecology. By exploring major theories in recent human origins through Africa’s poorly known western region, the project offers an opportunity to radically change our understanding of recent human evolution. The results will be broadly communicated through open access resources, including an online database and targeted public outreach activities.

Keywords: middle stone age,african middle pleistocene,african late pleistocene,west africa,lithic analysis,human evolution,habitat diversity
Chromatin architecture and Design (ChromDesign)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Italy,Germany,Germany,Germany,Switzerland,Switzerland,Belgium,France,France,Netherlands,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-09-01
End date: 2023-02-28
Duration (months): 54.0
Total project cost (EUR): 3408207.12
EU funding (EUR): 3408207.12
Participants: 17
Project status: CLOSED

ChromDesign is an innovative and interdisciplinary network of 10 European academic and private institutions that will characterize how 3D chromatin organization affects gene regulation during cellular differentiation and in several human disorders. We will train 13 Early Stage Researchers (ESR), equipping them with the skills, knowledge, expertise, and enthusiasm necessary to develop successful future careers in the biomedical field (in academia or the private sector). Together with European experts in chromatin biology, 3D genomics, and research design, these ESRs will work towards the goal of identifying novel alterations in chromatin topology responsible for cellular malfunctions to: i) develop new diagnostic tools, ii) effectively communicate research results through specific toolkits; and iii) identify novel therapeutic targets with the potential to be exploited as treatments. Alteration of gene regulation occurs naturally during aging and underlies several human diseases. Its better characterization requires a deeper understanding of the spatial organization of the genome. We will investigate how the genome organizes in 3D over time, and how the 3D organization is related to gene regulation in health and disease. We will use and develop technologies in imaging, cell biology, genomics, and computational modelling and will focus on translating our results into clinical applications. ESRs will thereby receive training with state-of-the-art technologies in distinct research areas and in modules with theoretical and hands-on sessions on transferable skills: entrepreneurship, management, communication, and outreach. ChromDesign comprises 6 work packages: WP1–4 address the 4 main areas of chromatin biology and 3D genomics; WP5 applies the knowledge obtained from WPs1–4 into translational research; WP6 develops (with a dedicated ESR) a set of design toolkits for communicating results to scientists, the public, and schools; and WP7 ensures quality training for ESRs.

Keywords: training,imaging,modeling,design,genomics,3d genomics,translational research,cell biology
Endoplasmic Reticulum Stress in Health and Disease (TRAIN-ERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Ireland,Austria,Spain,Israel,Ireland,Belgium,Sweden,France,Czechia,United States,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 3628756.8
EU funding (EUR): 3628756.8
Participants: 18
Project status: CLOSED

Endoplasmic reticulum (ER) stress is emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases. Thus ER stress represents a potential therapeutic intervention point to be exploited to develop novel therapies, diagnostic tools and markers for these diseases. However, exploitation is hampered by the shortage of scientists with interdisciplinary training that can navigate with ease between the academic, industrial and clinical sectors, and that have the scientific and complementary skills, together with an innovative outlook, to convert research findings into commercial and clinical applications. This proposal will bring young researchers together with world-leading academics, clinicians and industry personnel, who are united in (1) their goal of forming a network of excellence aimed at understanding the ER stress response mechanistically and quantitatively and (2) applying this understanding to identify and validate the most suitable intervention points in order to provide innovative knowledge-driven strategies for the treatment of ER stress-associated diseases. The TRAIN-ERS network will provide early stage researchers (ESRs) with high quality scientific and complementary skills training combined with international, intersectoral work experience. This will produce highly trained, innovative, creative and entrepreneurial ESRs with greatly enhanced career prospects, who will continue to advance the state of the art in the Biomedical field in their further careers, and will confidently navigate at the interface of academic, clinical and private sector research. The TRAIN-ERS research programme will provide the ESR’s with the knowledge and the cutting edge scientific and technical skills that will drive our understanding and exploitation of the ER stress response for therapeutic and diagnostic purposes.

Keywords: er stress,unfolded protein response,cancer,inflammation,neurodegeneration,therapeutic targets
Theory and Empirics of Asymmetry (TEA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Türkiye
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1276640.0
EU funding (EUR): 1276640.0
Participants: 1
Project status: CLOSED

Why is there a Volcker disinflation but no Bernanke re-inflation? It is not only because of the zero lower bound as a nascent literature is suggesting that monetary policy is more potent in a contractionary stance than in an expansionary stance away from the ZLB as well. But why? Why is it that central banks cut interest rates much faster than they raise them? Why does it seem like financial markets give much different responses to seemingly similar macroeconomic news at different times? Are these all related? This research project is about asymmetries in macroeconomics and finance. I will be working on these questions because our current understanding of these issues hints at some facets of asymmetries but is a long way from providing broad evidence and matching theories. I find these questions thoroughly interesting because the theory and empirical evidence we now have lets us ask the questions and understand their research and policy relevance but not yet satisfactorily answer them. Most of our macroeconomic models are linearized and linear models (with exceptions that effectively make the model piece-wise linear) do not generate asymmetric anything. But the issue is not in the solution method: nonlinear solutions of standard models also do not produce asymmetric responses in noticeable ways. Hence, although by experience we understand there are likely sizable asymmetries in macroeconomic and financial outcomes, we have neither extensively documented these nor understood what brings them about. This research program, then, will consist of five distinct but related questions: 1. Are there asymmetries due to the state of the business cycle and the nature of the shock? 2. Do financial markets behave as if market participants perceive the world to be asymmetric? 3. Do policymakers behave asymmetrically and if so why? 4. To the extent that there are asymmetries, what brings them about? 5. What kinds of policies should we be thinking of in a world with asymmetries?

Keywords: business cycle asymmetry,monetary policy,financial markets
Applying energy efficient measures for metal and metalworking SMEs and industry (EE-METAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Spain,Italy,Spain,Poland,Poland,France
Call: Organisational innovation to increase energy efficiency in industry (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1717456.25
EU funding (EUR): 1717456.25
Participants: 7
Project status: CLOSED

EE-METAL aims to provide enterprises with innovative technical, commercial and financial tools in order to overcome the existing barriers that hinder the adoption of energy saving measures. EE-METAL actions are mainly targeted to Metalworking and Metal Articles (MMA) SMEs, given that this sector is the biggest manufacturing sector in Europe and it is mostly composed by SMEs. EE-METAL actions will focus on overcoming: Awareness, information and technical capacity barriers to identify, evaluate and implement energy efficiency actions: EE-METAL will adapt and standardize for the sector existing methods and technologies such as energy audits, the standard ISO 50.001 and the use of Energy Monitoring Systems. Commercial and market barriers to the contracting of energy service companies (ESCos): development of a benchmarking study of energy service contracts and the role of ESCOs in the MMA and other industrial sectors; networking with ESCOs Associations for fostering ESCOs-SMEs contracts. Financial barriers to the implementation of energy saving measures: benchmarking the different financial models being implemented in the partner countries for financing energy saving institutions for providing clear information on type and size of investments needed. These two last actions will allow put in place mechanisms for funding the energy efficiency projects identified in the first action. In this sector, big energy savings can be obtained by the aggregation of many smaller savings. Furthermore five out of the seven project partners are Enterprise/Trade Associations (with 7000 associated companies) that will ensure that a critical mass is achieved. EE-METAL is in line with the following EU strategies and initiatives: first priority of the EU Energy 2020 Strategy for Achieving an energy efficient Europe; Energy efficiency plan 2011 (COM (2011) 109); A strategy for competitive, sustainable and secure energy (COM (2010) 639 final) and Directives 2012/27/EU-2

Keywords: energy efficiency,metal,metalworking sector,iso 5001,energy management systems,escos,energy audits
Advanced Distributed Pilot Line for More-than-Moore Technologies (ADMONT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Italy,Germany,Germany,Austria,Germany,Germany,Germany,Finland,Hungary,Sweden
Call: ECSEL Key Applications and Essential Technologies (IA) (ECSEL-2014-2, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 38905159.61
EU funding (EUR): 11096414.52
Participants: 15
Project status: CLOSED

The “Advanced Distributed Pilot Line for More-than-Moore Technologies” project (ADMONT) is focused on a powerful and versatile More-than-Moore (MtM) pilot line for Europe increasing the diversification of CMOS process technologies. The combination of existing expertise, technological capabilities and the manufacturing capacity of industrial and research partners creates a whole new ecosystem within Europe’s biggest silicon technology cluster “Silicon Saxony”. The distributed pilot line utilizes various MtM platform technologies for sensor and OLED processing in combination with baseline CMOS processes in a unique way and incorporates 2.5D as well as 3D integration of silicon systems into one single production flow. The technology modules, equipment and processes are not located in one single clean room, but are distributed between partners located in Dresden. This local concentration of micro- and nanotechnology facilities has various advantages for potential customer since it enables a short production cycle time and fast delivery. Such distributed MtM pilot line is unique in Europe as well as worldwide and will be implemented as “one-stop-shop” for partners and customer. It is supported by advanced design technologies to address the challenges of modelling and simulation of MtM relevant aspects like reliability, degradation effects, process variability, and IT solution aspects for MtM smart fabrication, fab automation and data processing to generate a smart infrastructure. The distributed pilot line is working as an open platform and is able to integrate future technologies for autonomous and smart system solutions. ADMONT is focused on four main key applications: smart energy, smart mobility, smart health, and smart production and essential capabilities like semiconductor process equipment and materials, design technology and smart system integration. The project consortium is organized and working along the value chain for ECS technologies in Europe.

Keywords: more than moore,cmos,silicon technology,distributed pilot lines,smart energy,smart mobility,smart health,smart production,electronic components and systems,safe operating area
Open Ocean Fish farms (OCEANFISH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Israel
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-2-2015, 2015)
Start date: 2015-08-01
End date: 2018-11-30
Duration (months): 40.0
Total project cost (EUR): 3354000.0
EU funding (EUR): 2347800.0
Participants: 1
Project status: CLOSED

Gili Ocean Technologies aims to become the leading off-shore (Open Ocean) aquaculture company. This will be achieved through the operation of fish farms as well as through the delivery of turn-key projects for other fish farmers based on our extensive off-shore fish farming expertise and advanced technologies. Aquaculture is rapidly growing. The FAO estimates that aquaculture will grow to over 62% of the worldwide supply of fish protein by 2030.However, the currently near-shore aquaculture faces significant problems e.g. relatively slow growth rate for the fish, high death rates, low stocking densities in the cages and intensive use of antibiotics in order to fight diseases. In addition, significant pollution in the coastal areas is very common as there is hardly any dispersing of organic matter in the ocean. This impacts the local ecology as well as the industry itself. OCEANFISH aims to finalize the development and start the commercialisation of the various technologies necessary to transform Gili's existing Subflex Classic systems to advanced and sophisticated open ocean systems improving growth rates, reducing ecological impact and providing the aquaculture industry with the tools necessary to meet the market demands. This is a significant market opportunity. To capture this opportunity, the OCEANFISH project aims to 1) increase the cost-efficiency of the Subflex aquaculture platform, 2) enable real off-shore farming, 3) enable growth of additional fish species and 4) commercialize the technology. The OCEANFISH system is a flexible submerged system of cages. The original technology was developed with the Technion, Israel's leading technological university. OCEANFISH is an excellent example of how humans can take better advantage of oceans in a highly sustainable manner and at the same time solve significant ecological challenges.

Keywords: ocean
Defining the role of Arp2/3 complex diversity at multiple scales of biology (ArpComplexity)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: United Kingdom,Portugal
Call: ERC Synergy Grant (ERC-2018-SyG, 2018)
Start date: 2019-07-01
End date: 2025-12-31
Duration (months): 78.0
Total project cost (EUR): 10715153.0
EU funding (EUR): 10715153.0
Participants: 3
Project status: SIGNED

The actin cytoskeleton of the cell is critical for the complex, integrated processes associated with development, operation and sustainability of the human body. The Arp2/3 complex consisting of seven protein subunits is essential to stimulate dynamic branched actin networks needed for multiple cellular processes. The Arp2/3 complex has always been considered as a single entity, but in humans and other mammals, three of the Arp2/3 complex subunits are encoded by two isoforms, thus allowing the formation of eight distinct Arp2/3 complexes. The Way lab has shown that Arp2/3 subunit composition dramatically affects the formation and stability of branched actin networks. The Way and Gomes labs have shown how specific Arp2/3 isoforms are essential for muscle development. Our synergistic, high-risk, high-gain goal is to define the role of Arp2/3 complex diversity at three hierarchies of biology: 1. Molecular basis of Arp2/3 diversification With purified isoform-specific complexes we will perform cryo-electron microscopy and single molecule fluorescence microscopy to reveal the structural variations and influence of Arp2/3 diversity on actin networks in vitro. 2. Cellular function of different Arp2/3 complexes With cells expressing specific Arp2/3 isoforms, we will use quantitative live cell imaging and cryoelectron tomography to reveal the dependence of cellular actin networks on Arp2/3 diversity and its functional consequences. 3. Developmental and physiological role of individual Arp2/3 complexes. With genetically modified cultured myofibers and transgenic mice, we will use an array of imaging approaches to reveal the contribution of different Arp2/3 family members to muscle development, structure and physiology. Our interdisciplinary plan builds on the strengths of our three labs, takes advantage of unique reagents and powerful model systems, and will allow us to determine how Arp2/3 diversity contributes to biological complexity at multiple scales.

Keywords: actin,arp2,3 complex,skeletal muscle,cryo em