Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Avoiding the Negative Impacts produced by Plastic materials in Humanitarian contexts (ANIPH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Spain,Greece,Canada,Netherlands,Belgium,Italy
Call: Programmed biodegradation capability of bio-based materials and products, validated in specific environments (HORIZON-CL6-2024-CIRCBIO-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4534567.86
EU funding (EUR): 3999801.25
Participants: 9
Project status: SIGNED

Biobased and biodegradable plastics products (BBpPs) are emerging as a key piece to solve the negative impact of fossil-based plastics in the environment. A relevant case where BBpPs can play a key role in avoiding pollution is in single use applications used in humanitarian contexts (such as natural disasters or armed conflicts), where appropriate waste management systems are usually not feasible. Plastic waste, mainly health care & packaging waste, is largely contributing to uncontrolled waste in humanitarian contexts, and addressing their environmental impacts is required. One of the most promising biodegradable biopolymers is the polyhydroxyalkanoates (PHAs) family which offer functionalities, are biocompatible, but also fully biodegradable in relevant environments without causing microplastic pollution. ANIPH will create a new PHA value chain to produce modern wound dressings and recyclable water barrier packaging while being biodegradable in all relevant environments (soil, freshwater, marine). The biodegradation will be programmed during the PHA production, formulation & compounding, and conversion stages. An AI predictive tool and a digital traceability tool will support these aims by predicting the biodegradation, properties, & ecotoxicity, and ensuring the traceability of the materials and products. Moreover, sustainable choices, proper use and safe disposal of BBpPs will be fostered through ANIPH contribution to Information & Labelling Systems and by delivering capacity building resources. Our project gathers eight partners from six European countries leaders in different fields of knowledge, from bioplastic production to end of life assessment. Adoption of ANIPH value chain will produce relevant outcomes: yearly saving 22.43 kt of crude oil thanks to a reduction of 43% and 68% of CO2 emissions compared to packaging and wound dressing respective fossil counterparts, recirculating 1,475 kt of biomass, avoiding the use of 12.93kt of hazardous substances.

Keywords: bio based and biodegradable plastics,programmed biodegradation,biodegradation assessment,polyhydroxyalkanoates,phbv,phn,safe and sustainable,information and labelling
Beyond the Oink: Salivary Gland biomarkers as the new frontier in pig welfare assessment (PoWe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-15
End date: 2027-09-14
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

The European Union has 134.32 million heads of pigs and produces the second-largest amount of pork in the world. In view of the importance of the livestock sector, the EU is increasingly interested in animal welfare measures across its entire livestock production system. This is because optimized biosecurity measures and management practices which are preventive tools for spread of pathogens does not guarantee high animal welfare or optimal sanitary status. The project, Porcine Welfare (PoWe) aims to develop an innovative analytical tool for monitoring pig welfare using non-invasive analytical tool for monitoring pig welfare using non-invasive and painless saliva sample collection. To achieve the objective of PoWe, the researcher will combine her knowledge in molecular biology, clinical chemistry and pathology with the expertise in proteomics, organoid technology and veterinary clinical analysis of the supervisors in the host and secondment institutions. The analytical tool will be constructed by utilising the best salivary gland (SG)-derived biomarkers identified in single-cell and organoid cultures of the three major SG subjected to experimental infection and heat stress. The gender-specific biomarkers identified by proteomics in-vitro will be validated in saliva samples of pigs in field conditions and will reveal gender-based differences in the biomarkers that are produced in response to welfare dysregulation. The proposed tool will enhance early and optimal disease monitoring that could prevent avoidable mortality, reduce financial investment on therapeutic treatments, and reduce the overuse or misuse of antimicrobial agents and thus improve animal welfare. The biomarkers that will be validated in PoWe will be used to develop saliva-based diagnostic test kits or point-of-care devices for an early detection of pathological conditions by farmers before the arrival of a veterinarian. Thus healthier pigs and increased safety pork product will be obtained.

Keywords: pig welfare organoid culture salivary gland proteomics immune proteins animal health,biomarkers,welfare monitoring,disease detection,no invasive sampling collection
Towards the ultimate breath analysis -based continuous healthcare (VOCORDER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Estonia,France,Greece,Belgium,Switzerland,Germany,Lithuania
Call: EIC Pathfinder Challenge: Towards the Healthcare Continuum: technologies to support a radical shift from episodic to continuous healthcare (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2027-03-31
Duration (months): 42.0
Total project cost (EUR): 3873437.5
EU funding (EUR): 3873437.5
Participants: 12
Project status: SIGNED

VOCORDER develops innovative components based on disruptive technologies that aims to render breath analysis testing a holistic, highly efficient health monitoring apparatus that can be seamlessly integrated into everyday life. The project capitalizes on recent developments on mid-infrared lasers and moves the technology well beyond the state-of-the-art to demonstrate at TRL5 a highly efficient multiple species (gases) breath analysers that can with a 5 sec use of the device, and the use of artificial intelligence-based signal processing, can conclude on the health status of the individual, just like the fictional Star Trek Tricorder. To record and analyze the maximum amount of information on the individual health status completely unobtrusively, exhaled breath is among the most convenient body fluids as can be obtained at large quantities, practically without any causing discomfort to the user, with strong potentially to seamlessly integrate into everyday life. Exhaled breath contains more than 1’000 substances which can serve as efficient biomarkers, the measurement of concentration of which can provide a clear provision of the health status of the individual while the diagnosis of some diseases or pathological process in human body can be obtained early. For a truly seamlessly integration in a plethora of settings, VOCORDER examines the ways to render the final instrument compact and potentially inexpensive.

Keywords: breath analysis,continuous monitoring,pulmonary diseases,volatile organic compounds,artificial intelligence,early diagnosis,early detection,continuous healthcare,mid ir,self mixing,tricorder
Preclinical development of new nucleoside-based drug against leukemia (leuCAB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The current treatment landscape for leukemia, particularly concerning AML (acute myeloid leukemia) and MDS (myelodysplastic syndrome), is constrained by the instability of hypomethylating agents which are regularly used in elderly, medically non-fit patients (high-risk). This instability restricts their spectrum of application, leaving a significant gap in effective treatment options. Despite research into alternative therapeutic approaches the need for a mild treatment option with high success rates in this patient population remains unmet. Carbacitabin (CAB) emerges as a promising solution to these challenges. This novel epigenetically active compound exhibits enhanced stability against hydrolytic cleavage and enzymatic metabolization. In AML PDX mouse models, CAB demonstrates significantly improved efficacy and vastly reduced toxicity, making it an optimal candidate for leukemia treatment, particularly for those high-risk patients. Funding from the ERC PoC aims to support essential preclinical steps towards fully realizing the potential of CAB. Those include, further optimization of the lead structure of CAB to enhance targeting and thorough preclinical studies to evaluate the safety and efficacy of CAB. Additionally, scaling up the synthesis of CAB is crucial to meet the demand for large-scale production required for preclinical and subsequent clinical trials. Furthermore, efforts to solidify intellectual property (IP) protection and conduct an in-depth freedom-to-operate (FTO) analysis are necessary to safeguard CAB's market position. Establishing a spin-off company dedicated to the clinical studies of CAB will require engagement with essential stakeholders, including potential investors, pharmaceutical partners, legal advisors, and regulatory consultants during leuCAB. This comprehensive approach will ensure the effective translation of CAB from bench to bedside, bringing new hope to patients, especially those battling AML and MDS.
Proximity-induced magnetism and spin transport in graphene/magnetic oxide heterostructure interfaces (2DMagspin)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

Although graphene is known for its superlative electronic properties, it is intrinsically characterized by weak spin-orbit coupling and paramagnetic nature at low temperature. We propose to circumvent this issue by combining graphene with transition metal magnetic oxides (graphene/MO) in a unique series of artificially layered heterostructures. The presence of the magnetic oxide layer will allow us to investigate proximity induced magnetism and anomalous Hall effect (AHE) in graphene due to the presence of high order d-orbitals and ensuing charge transfer induced hybridization. To that aim, perovskite manganate oxides will be initially investigated and then extended to cobalt or magnesium-based ferrites for room temperature applicability. Finally, we aim at fabricating novel graphene/MO-based heterostructure spin devices to test their feasibility for spin transport applications.

Keywords: 2d materials,magnetic oxides,heterostructures,spintronics
Identifying key axis to modulate CD8 T cell exhaustion and improve cancer immunotherapy (TREAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1518750.0
EU funding (EUR): 1518750.0
Participants: 1
Project status: SIGNED

Cancer Immunotherapy has revolutionized Clinical Oncology. Yet, CD8 T-cell exhaustion remains a leading cause of treatment failure. This hypofunctional program suppresses anti-tumor CD8 T-cell responses and is reinforced by a stable epigenetic program that prevents exhausted CD8 T-cells (Tex) from reverting to more functional states. Checkpoint inhibitors such as anti-PD-1 can temporally relieve some constraints on TEX and be curative. However, this approach alone does overcome the epigenetic restraints of exhaustion which likely explains the lack of long-term benefits in many patients. Combinatorial approaches are needed to achieve durable protection in more patients. Yet, an incomplete understanding of TEX biology has provided little rationale for relevant therapeutic interventions. Recent identification of an “effector-like” subset of TEX (TEX intermediate; TEXint) that mediates the benefits of PD-1 therapy and partially escapes the epigenetic strains of exhaustion, has brought new therapeutic perspective. Indeed, manipulating key pathways related to TEXint cells formation such as the IL-2/Stat5a axis potentiates TEX responses to PD-1 blockade and partially reprogram these cells towards more durably protective cell states. These findings provide compelling proof-of-concept that targeting key pathways driving Texint cell formation can unlock new strategies to overcome exhaustion and bolster PD-1 therapy. Building on this novel concept, our proposal utilizes advanced murine models alongside molecular engineering, large-scale genetic perturbation tools (CRISPR), and single-cell multiomics to uncover and characterize new regulatory pathways for Texint cell development. Our goal is to unveil new strategies to improve PD-1 therapy and advance next-generation anti-cancer immunotherapies.

Keywords: cd8 t cell exhaustion cancer immunotherapy checkpoint blockade combinatorial therapy lymphocytic choriomeningitis virus lcmv murine models cytokines single cell sequencing crispr screen epigenetic reprogramming
Design Framework for Single-step Additive Manufacturing of Liquid Metal-based Plasma-facing Surfaces for Fusion Reactors (ALPS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: CLOSED

Energy is now the topic of a full-blown political and economic crisis in Europe. Nuclear fusion is a promising option to replace fossil fuels as a limitless, safe, and CO2-free source of energy. However, some challenging engineering issues must be addressed before fusion can supply electricity to the grid. The fusion reactor's first wall is subject to severe heat flux, erosion, and sputtering. Therefore, new materials must be developed. A liquid metal wall has been introduced as a viable solution to address all issues associated with the first wall of a fusion reactor. The ALPS project aims to deliver an innovative multi-objective design framework based on Additive Manufacturing (AM) of tungsten to address the main challenges associated with Liquid Metal walls and produce a state-of-the-art plasma-facing material for future fusion reactors. The Alps project will reach its goals by (1) introducing design guidelines for precision AM of tungsten, (2) AM of tungsten-copper multi-materials, (3) AM of a high-performance tungsten capillary porous system and (4) assessment of the produced liquid metal walls in fusion conditions. Since this is a highly interdisciplinary research topic, the ALPS project will connect two competencies existing at the applicant and TU/e, precision AM and the design and testing of liquid metal walls, through a European postdoctoral fellowship, to present a new concept of using AM in fusion research. The nature of this project is high-risk/high-gain. However, the existing competencies at the applicant, host, and associated partner (DIFFER) make the ambitious goals achievable. Contribution to fusion research as one of the promising sources of future energy is a strong motivation in the applicant to implement this research and push the state of the art in materials for fusion energy. Through this fellowship, the applicant will acquire new knowledge, skills, and competencies in top-ranked institutes to develop his career.

Keywords: nuclear fusion,additive manufacturing,plasma facing materials,liquid metal divertors
Hybrid detectors for medical radiation therapies (IDEATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-02
End date: 2027-09-01
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 2
Project status: SIGNED

IDEATE aims to develop a ground-breaking class of high energy radiation direct detectors based on perovskite (PVK) and organic (OS) thin films. The target is to define and implement gender-specific medical protocols during cancer radiotherapy treatments, thanks to a beam monitoring and real-time measurement of the dose delivered to the patient. This ambitious and revolutionary result will be attained by four intermediate goals: 1) model the mechanisms of interaction between ionizing radiation and PVK and OS thin films, 2) design and fabrication of PVK/OS single pixel detectors with different device architectures, 3) validation of each material/device architecture single pixel under X-Rays and proton beams to identify the best combinations which fulfil the target specifications, 4) realization of two DEMOs formed by a 3x3 pixels matrix onto flexible substrates, of a dedicated portable read-out electronics and validation of the integrated system under relevant irradiation conditions in medical radiation therapy facilities. The final DEMOs will represent the starting prototypes to be industrialized and commercialized by a start-up that I’m going to set up at the end of the fellowship. The interdisciplinarity and intersectoral approach adopted by IDEATE will be the result of the merge of different competences offered by University of Bologna (12-months return phase, supervisor Prof. Fraboni, expert in ionizing radiation detectors and semiconductor defect states characterization), by Columbia University (23-months outgoing phase, supervisor Prof. Kymissis, expert in electronic devices based on unconventional materials) and Kairos Sensors LLC Company (1 month internship, expert in industrialization and commercialization of innovative radiation sensing technologies). I will receive excellent training during the entire action enforcing my scientific skills but also ability in communication, dissemination, technology transfer, sustainable development, and female leadership.

Keywords: ionizing radiation detectors,organic semiconductors,perovskites,flexible electronics
Hopeful and resilience perspective in climate change education to inspire (promote) action competence (HARP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Czechia,Netherlands,Austria
Call: Twinning Green Deal (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1499904.38
EU funding (EUR): 1499904.38
Participants: 3
Project status: SIGNED

The HARP (Hopeful And Resilience Perspective) project, a collaborative endeavor involving Masaryk University, University of Utrecht, and University of Vienna, targets the gaps and inconsistencies in Climate Change Education (CCE) across Europe. HARP is designed to foster actionable, inclusive, and emotionally-engaging CCE strategies to promote climate change mitigation. Masaryk University, renowned for its focus on climate change education, acknowledges the need for a quantitative approach to CCE, expertise currently excelling at Utrecht University with specialists like Boeve-de Pauw Jelle and a mixed method found in Vienna with the likes of Andrea Moeller. HARP identifies the uneven state of CCE in Europe, often fragmented and insufficiently integrated into national curricula. Its objective is to transform CCE into a primary driver for climate action, making CCE more holistic by incorporating various disciplinary perspectives. The project is designed to offer actionable recommendations, ultimately aiming to cultivate a climate-literate populace pivotal for the imminent climate challenges. Acknowledging that existing CCE often overlooks the emotional dynamics of climate change, which significantly influences action engagement, HARP promotes a comprehensive approach to CCE (source). The initiative targets two primary objectives. Firstly, enhancing the capacities of partner institutions for Climate Change Education Research (CCER), emphasizing strengthening research design and improving the overall CCER quality across Europe. Secondly, the formation of a European CCE and CCER network to bolster collaboration and share findings, complemented by national and international advisory boards. In sum, HARP's intent is to uplift the quality, breadth, and influence of CCE, enabling a community of learners, educators, and researchers equipped to significantly contribute to climate change mitigation.

Keywords: climate change education cce climate change education research ccer climate related emotions higher educational institutions hei and climate change