Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chromatin organization PROfiling with high-throughput super-resolution microscopy on a CHIP (PROCHIP)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,France,France,France,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-09-01
End date: 2022-02-28
Duration (months): 42.0
Total project cost (EUR): 2496525.0
EU funding (EUR): 2496525.0
Participants: 9
Project status: CLOSED

Cancer is both a genetic and an epigenetic disease whose outcome is influenced by tumor microenvironment, which represents the major driving force of tumorigenesis causing the functional heterogeneity observed in most cancer types. Defining the 3D-organization of cancer-associated chromatin domains would represent a new frontier to decipher tumor heterogeneity. None of the currently available technologies permit to rapidly analyze thousands of cells and profile their chromatin organization at single cell level, as needed for medical diagnosis and therapeutic guidance. The goal of the project is to build a high-throughput super-resolution microscope in a microfluidic chip smaller than a coin. With this device we will provide high resolution imaging of hundreds of cells at the diffraction limit and beyond, with minimal photo-toxicity. Femtosecond laser micromachining allows fabricating with accurate precision optofluidic components as waveguides, microchannels and lenses in a glass substrate. We will integrate them in a single chip, to achieve the required illumination path for advanced fluorescence excitation and sample movement: in the same chip biological samples will be scanned along fluidic channels in a fully automatic fashion. High-throughput data on chromatin distribution in hundreds of samples will be generated, allowing to decipher the pathogenic function of tumor heterogeneities in tumor progression. These data will be used as benchmarks for predicting differential responsiveness and/or resistance of cancer cells to targeted therapies opening brand new possibilities for medical diagnosis and therapeutic guidance. The consortium is formed by young scientists from Universities in the field of photonics, computer sciences and epigenetics, and a leading company in microfluidics.

Keywords: fluorescence microscopy,lab on chip,optofluidics,structured illumination microscopy,breast cancer,chromatine structure
Understanding key factors for the use of bioactive lipid nanoparticles to modulate the functionality of complex food systems (NANOLIPID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

The use of lipid nanoparticles as carriers of lipophilic functional compounds is emerging as a promising way to efficiently deliver food ingredients. There are evidences that bioactive compounds incorporated in lipid nanoparticles present an enhanced bio-accessibility in the gastrointestinal due to their small droplet size. However, the incorporation of active nanosized ingredients in foods remains a challenge for the food sector. Lipid nanoparticles may interact with the food matrix components causing destabilization phenomena or binding, which in turn might decrease their biological activity. Moreover, food processing operations used after the incorporation of the active lipid nanoparticles may have an impact in their properties. In this context, NANOLIPID, aims to contribute to the design, characterization and application of bioactive lipid nanoparticles towards a more rational and optimal use of food ingredients. For that purpose, the major goal of this proposal is to obtain stable lipid nanoparticles containing carotenoids (β-carotene, lycopene and lutein), incorporate them in complex food systems and assess their digestibility and bio-accessibility under in vitro simulated digestion conditions. NANOLIPID is a multidisciplinary proposal covering the formulation of lipid nanoparticles and use of state of the art techniques for nanomaterial characterization, food processing, and analysis of digestion and in vitro bio-accessibility. The fellow, who recently obtained her PhD degree in the University of Lleida (Spain), focuses on the study of the functional properties of lipid nanoparticles. Currently, she is post-doctoral researcher at the Food Science Department at University of Massachusetts (USA), one of the most active research groups in the field of delivery systems. The applicant would be one of the first researchers in Europe to study the real implications and benefits of incorporating functional lipid nanoparticles in food products.

Keywords: lipid nanoparticles,nanoemulsions,carotenoids,foods,ingredients,food processing,food matrix,interactions,in vitro digestion,lipid digestibility,carotenoid bio accessibility
Decoding Stress Resilience (DE-STRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

Stress is a common feature of our lives yet some people respond to stress better than others, a concept known as resilience. There is a growing body of experimental data which has implicated several brain structures and molecular mechanisms. However to date there has been limited focus on the bed nucleus of the stria terminalis (BNST) and the mechanisms in this brain region which could be involved. One of several proteins expressed by the BNST, which is a key regulator of the stress response, is the pituitary adenylate cyclase-activating peptide (PACAP). But the expression of PACAP is under the control of stress-responsive nucleotides called miRNAs. Thus, there exists a complex system in the BNST which regulates the stress-response and hypothetically could be involved in mediating resilience. To test this hypothesis, the DE-STRESS project will conduct a series of experiments with the objectives of (i) determining whether PACAP expression in the BNST is different in states of resilience and susceptibility, (ii) identifying miRNAs that are differentially expressed in these states and which regulate PACAP expression and (iii) elucidating their functional effects on the stress response. Hence, the DE-STRESS project uses an innovative approach to decode the concept of stress resilience and will advance understanding of the pathophysiology of stress-induced disorders. Additional objectives of the project include dissemination and transfer of knowledge to relevant stakeholders, forming collaborations within academia and industry with a view to commercialising research findings as well as develop project management and career development skills of the applicant. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant will add to developing his potential to achieve professional maturity and leadership in the field so that he may continue to make significant contributions to society and the economy.

Keywords: chronic stress,depression,anxiety,resilience,mirnas,next generation sequencing
Elucidating the role of Arid1a in adult liver (EPILIPRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Liver cancer is the fifth most common malignancy in men and the eighth in women worldwide. Of note, liver cancer is tightly associated with tissue damage due to the high metabolic and drug detoxification activity of the liver. Increasing evidence demonstrates that toxic agents induce the activation of a resident ductal-progenitor population capable of regenerating the tissue. Therefore, understanding molecular mechanisms governing liver progenitor cells is essential for preventing tumour initiation and progression. The aim of this proposal is elucidating the role of Arid1A (the DNA-binding subunit of the nucleosome-remodelling complex SWI/SNF) in adult liver progenitors by using novel 3D-organoid cultures, which allows long-term expansion of adult ductal-progenitors derived from the healthy liver. Moreover, genome-wide analysis and in vivo approaches will be implemented for accomplishing the goals of the project. Supporting a crucial role for Arid1a in liver progenitors, Arid1a expression is high in organoid cultures and is up-regulated in the adult liver upon damage as compared to the healthy liver. Importantly, Arid1a and other SWI/SNF subunits are mutated in liver cancer, suggesting that Arid1a and SWI/SNF exert a tumour suppression function. In line with this, our preliminary results indicate that depletion of Arid1a and SWI/SNF components increases organoid formation efficiency. Overall, this research plan will shed light on the function of Arid1a and the SWI/SNF nucleosome-remodelling complex in adult liver progenitors and mouse liver regeneration, providing novel hints into their role in carcinogenesis.

Keywords: epigenetics,nuclesome remodelling,adult stem cells,arid1a,regeneration,chromatin,transcription,3d cultures,organoids,liver progenitors,adult liver
NEW GENERATION OF EFFICIENT TRAWL DOORS AND HARMLESS SEAFLOOR FISHING (EKKO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Iceland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Trawling is a fishing method that involves pulling a net through the water behind a vessel and trawl doors are the steel plates attached to the fishing net to keep it open during fishing. Conventional square shaped trawl doors consume at least one quarter of vessel’s energy cost due to their inadequate design. Conventional doors not only consume large fossil fuel (which increases carbon footprint, air and sea pollution) but also harms the seabed, marine habitats and biodiversity (especially bottom trawling which catches the fish at or close to the seafloor). Ný Toghlerahönnun ehf is a company with more than 25 years’ experience in the fishing industry. We have been working on developing more advanced, efficient and sea ecology friendly fishing trawl doors for the last 5 years, resulting on EKKÓ (patent pending). Due to its superior engineering design, airplane wing shape, EKKÓ trawl doors never touch the seabed, are multi-function, consume 10% less fuel (equivalent to €100K per ship annually), decrease weight on board lessens handling time and maintenance cost besides protecting the marine environment and increase profitability and economic growth of our seas. EKKÓ has been defined by experts as “the most innovative trawl doors seen in 25 years” and is gathering huge interest from main players of the international fishing industry such as HB Grandi, the largest Icelandic fishing company. University of Iceland, University of Newfoundland (Canada) and the Icelandic Marine Research Institute, have all participated in EKKÓs development. Government of Iceland, granted €88K to EKKO project for “Increasing the value of fish or fish equipment”. EKKÓ have also already appeared on numerous national newspapers. Keeping the same enthusiasm and upon the great results that we have since achieved, we envision ourselves becoming the biggest and most revolutionary trawl door suppliers in the world within ten years, protecting our seabed from fishing activities.

Keywords: blue growth,fishing,trawlers,trawl doors,seabed
Feasibility Study to Demonstrate Effectiveness and Efficiency of Enamel Remineralisation using Reminova's EAER (Electrically Accelerated Enhanced Remineralisation) Technology for Dental Applications (Reminova02)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-05-01
End date: 2016-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Dental caries (tooth decay) is the most common communicable disease, globally affecting 36% of the adult population. It has been identified by the World Health Organisation (WHO) as a major global public health crisis (2008) and costs the European economy an estimated at €60Bn. Reminova is developing technology that "regrows" enamel, replacing the need for dental anaesthesia and drilling in the treatment of caries. The novel approach requires the delivery of three formulations to the tooth using a tiny (unperceivable) electric current in a process known as Electrically Accelerated Enhanced Remineralisation (EAER). This will be used to treat caries in-office without the need for tooth tissue removal. Our development has been welcomed by both end consumers and the dentistry sector and there is a strong market pull to get our technology to market. Patients want a painless solution that maintains and repairs their teeth, so they may retain them throughout their lifetime. Dentists are keen to embrace a shift to preventative and curative dentistry as opposed to the current reparative approach used when drilling and filling teeth. To achieve market success it is anticipated the device should control rapid remineralisation of precavitated lesions within existing timeframes and treatment pathways. This Phase 1 H2020 award would be used to undertake initial feasibility work and planning on how we can optimise remineralisation to a 15 minute time-frame. We believe that this is critical to the commercial viability and scalability of an identified €1.7–4.4Bn global market in the first 3 years of market entry for the device. The core activities of our phase 1 project would be initial feasibility work on techniques for optimisation and building a suitable approach and methodology for a subsequent phase 2 application. This will be essential to demonstrate the effectiveness of the technology to meet customer needs and validate market claims, thus achieving commercial success.

Keywords: dental,teeth,tooth,decay,enamel,remineralisation,iontophoresis,hydroxyapatite,nano particles,health,pain free,dentistry,whitening,erosion,sensitivity,endodontics,orthodontics
Cybersecurity and privacy dialogue between Europe and Japan (EUNITY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Support the Union's external security policies including through conflict prevention and peace-building
Action type: Coordination and support actions
Countries involved: Spain,Belgium,Greece,Poland,France
Call: EU Cooperation and International Dialogues in Cybersecurity and Privacy Research and Innovation (H2020-DS-SC7-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 499812.5
EU funding (EUR): 499812.5
Participants: 5
Project status: CLOSED

The EUNITY project addresses scope 2 (international dialogue with Japan) of objective DS-05-2016 of the H2020 work programme. This two years project aims at developing and encouraging the dialogue between Europe and Japan on cybersecurity and privacy topics. The partners involved have a long-standing history of research on both topics at the European level, as well as cooperation with Japan. EUNITY has 3 main objectives: 1. Encourage, facilitate and support the ICT dialogue between relevant EU and Japanese stakeholders on matters relating to cybersecurity and privacy research and innovation issues; 2. Identify potential opportunities for future cooperation between European and Japanese research and innovation ecosystems; and 3. Foster and promote European cybersecurity innovation activities and increase the international visibility of EU activities in cybersecurity . To meet these objectives, EUNITY will first gather relevant stakeholders in at least two workshops, one in each geography (EU and JP), taking advantage of co-location with other events as much as possible. It will also thanks to the expertise of its members collect the appropriate existing research agendas, legislations and business practices in Europe and Japan. It will then analyze the information collected to formulate recommendations, including business opportunities and a research agenda. A particular attention will be brought to the similarities of the research and market strategies, as well as the differences that must be taken into account when addressing both markets. EUNITY will operate in close relationship with the European Cyber Security Organization association, the cybersecurity cPPP signatory with the Commission. EUNITY will cover all the constituencies of ECSO (large organizations, SMEs, public bodies, associations, clusters, RTOs) thanks to both the direct participation of its partners to ECSO and to their ties with industry associations, cluster and public bodies.
Streamlined carbon dioxide conversion in ionic liquids – a platform strategy for modern carbonylation chemistry (CARBOFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1963515.0
EU funding (EUR): 1963515.0
Participants: 1
Project status: SIGNED

Since the discovery in the nineteenth century, carbonylation chemistry has found broad applicability in chemical industries and become now a key technology for bulk and fine chemical synthesis. Despite its substantial toxicity, carbon monoxide (CO) is commonly used as carbonyl source causing considerable safety issues, particularly when used on bulk scale. The replacement of this hazardous gas with more benign surrogates would be highly desirable, and recent ideas focus on the valorisation of carbon dioxide as abundant, non-toxic and renewable carbon resource. However, few industrial processes utilise carbon dioxide as a raw material, and potent catalysts are required to overcome its thermodynamic and kinetic barrier. In this regard, ionic liquids show considerable potential as cooperative media as they can solubilise large concentrations of carbon dioxide but also strongly interact and activate carbon dioxide. This project focuses on the photocatalytic reduction of carbon dioxide in ionic liquids and its successive conversion into carbonyl compounds. Several goals need to be realised, including fundamental studies and optimisation of the ionic liquid co-catalysed photocatalytic reduction of carbon dioxide to produce CO under mild conditions (Goal 1). The reactivity of formed CO in supercritical carbon dioxide with various organic substrates needs to be explored (Goal 2) before finally developing a streamlined and continuous process for the direct formation of carbonyl compounds from carbon dioxide (Goal 3). I envision that the photocatalytic activation of carbon dioxide in combination with the positive features of tailored ionic liquids as co-catalysts may overcome problems currently associated with carbon dioxide utilisation, eventually replacing the long-standing bastion of CO-based carbonylation chemistry with novel solutions.

Keywords: supported ionic liquids,supercritical carbon dioxide,carbonylation reactions,task specific ionic liquids
The next generation energy management solution for industry 4.0 (NEMASIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The industrial sector emits about 28% of global greenhouse gas emissions (mostly CO2), making it a major contributor to global warming and rising environmental emergency. At the same time, the current generation of energy management software is far from enabling efficient energy management at complex industrial sites. The available applications are not able to capture the full process chain, including energy conversions and locally produced commodities which are very typical in the industry. The challenge lies not only in applying analytics to enormous amounts of energy data, but also in linking this data with external information – industrial processes and production data, regulatory info and market data. We tackle these challenges by implementing novel modelling techniques. The Energy Hub is the first energy management platform that makes complex industrial processes fully energy transparent and complies with all upcoming regulation. The Energy Hub unlocks to an unprecedented extent insight into efficiency, deviations and cost allocation, down to product level and in real time, that none of the other tools is currently able to compete with. It leads to savings in energy consumption from 5% to 15%, helping industrial companies to reduce CO2 competitively. By boosting efficiency, the Energy Hub contributes to achieving climate goals and sustainable economic growth. Our value proposition has been validated by numerous industrial giants including our early adopters Johnson & Johnson and Pfizer. The 500 largest targeted customers in the EU alone represent 3,500 industrial sites with a €300 million recurring revenue potential to us per annum. Our target for 2025 is to have at least 500 industrial sites connected to the Energy Hub thus saving 1% CO2 emissions in the EU. This feasibility study is aimed at validating technical and economic feasibility of the Energy Hub before moving forward with end-stage development within the framework of the EIC Accelerator programme.

Keywords: industry,industrial sector,industry 4 0,energy transition,energy transparency,climate change,energy disclosure,decarbonization,industrial process,production