Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Marine forest coastal restoration: an underwater gardening socio-ecological plan (OCEAN CITIZEN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Italy,Israel,Spain,Denmark,Germany,Norway,France,United Kingdom,Ireland
Call: European Blue Parks (HORIZON-MISS-2021-OCEAN-02, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 11183070.79
EU funding (EUR): 10369172.25
Participants: 25
Project status: SIGNED

Following the non-achievement of the AICHI targets and most of the Good Environmental Status objectives for 2020, active restoration has been emerged (also envisaged by the EU) as one of the preferred tools that may boost sequels of marine protected areas and other conservation measures. Restoration acts promote biodiversity, enhance carbon sequestration and accelerate coastal and offshore resilience. Yet, we still lack a program that combines conservation and restoration under a unified setting, as the involvement of local citizen, embracing socio-economic parameters into opportunities. Thus, an advanced restoration program must conjoin ecological perspectives together with societal commitment and clear economic benefits for local communities. Above all, it must be designed with continuity beyond the lifespan of a project. Responding to the above, OCEAN CITIZEN proposal represent a novel restoration approach in which (1) restoration is depicted as a toolbox holding ubiquitous properties and as such it is experienced in 3 sites, representing different marine ecosystems (in one of the sites all tools are used in concert) and different environments: subtropical, tropical and cold temperate; (2) a profession of “gardeners of the sea” is created and endorsed, including detailed curriculum; (3) the project targets the restoration of the most neglected marine biome, encompassing the various types of Marine Forest (MF) organisms (seagrasses, seaweeds, sponges, corals, gorgonians, etc.);(4) new ecoengineering aspects are applied, including Integrated Multitrophic Aquaculture and Smart Enhanced Reefs (SER); the SERs act as substrates for massive recruitment and transplantation of MF organisms (5) the is performed on land, and in situ, from shallow, mesophotic to continental shelf areas (to 90-100 meters depth); (6) a novel approach for C sequestering and sink (7) the full involvement of citizens and local stakeholders with a complete business plan.

Keywords: blue carbon ecosystem engineers benthic suspension feeders seagrasses seaweeds citizen science ecosystem services imta business plan ocean literacy blue economy tourism
A training network for the design of synthetic carbohydrate-based vaccines in the fight against multi-drug resistant nosocomial pathogen Acinetobacter baumannii (ACINETWORK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Germany,Spain,Sweden,France,Denmark
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2801262.86
EU funding (EUR): 2689603.2
Participants: 17
Project status: SIGNED

Bacterial infections are a societal burden with profound medical and socio-economic impacts. Although antibiotics can be effective, the continuous emergence of bacteria with antimicrobial resistance calls for the introduction of novel therapeutics. In this regard, glycoconjugate vaccines (GV) hold a prominent role in the fight against AMR bacterial strains. They are based on the chemical conjugation of one or more pathogen-associated saccharide antigens to immunogenic carriers, leading to a long-term protective immunity. ACINETWORK will focus on the development of GV against severe and life-threatening infections caused by antimicrobial resistant Acinetobacter baumannii strains, which are a major cause of nosocomial diseases and for which no vaccine exists. ACINETWORK wants to overcome the limitations of currently licensed GV, due to highly heterogeneous composition and batch wise variability, by innovatively using structurally-defined synthetic oligosaccharide antigens to develop GV with well-defined composition, higher purity and better safety profiles. The manufacturing of such GV is also more rapid and cost-effective. Thus, this project will set synthesis and testing pipelines that will serve as the prototype for the development of GV against other bacteria. The ACINETWORK consortium comprises universities and SMEs with a unique complementary expertise, ranging from carbohydrate chemistry to nanotechnology, immunology and microbiology, which garantees the realization of the new GV. The goal of ACINETWORK is to also forge 10 young experts in the design of these novel medical solutions with an integrated training program, which will equip them with a large battery of scientific and transferable skills. The multidisciplinarity of the consortium ensures a fertile and stimulating environment in which these young researchers will acquire unique competencies in vaccine design, development and production, which will be central at putting Europe at the forefront of GV.

Keywords: synthetic organic chemistry,automated synthesis,glycoconjugates,polymeric nanoparticles,gold nanoparticles,monoclonal antibodies,immunology,vaccines,acinetobacter baumannii
Trustworthiness in the Age of LLMs: From theory to practice (FORSEE-HOP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Ireland,Armenia
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 24.0
Total project cost (EUR): 598513.75
EU funding (EUR): 598513.75
Participants: 2
Project status: CLOSED

FORSEE-HOP enhances the Horizon Europe FORSEE project by adding a dedicated work package (WP9) led by ETICA, AUA Center for Ethics in Public Affairs. WP9 will focus on trustworthiness as a core criterion for successful, socially accepted and human-friendly AI and will offer (i) conceptual clarification and analysis of trustworthy AI in the face of pressing new challenges posed by Large Language Models (LLMs) and (ii) through an interdisciplinary approach, combining philosophical inquiry with empirical and technical data, will extend the scope of FORSEE’s research on the normative impact of AI on the two crucial domains of environment and healthcare—where AI deployment has both significant promise and risk. FORESEE-HOP will examine the carbon and resource costs of LLMs alongside their potential to support global and intergenerational justice. In the area of healthcare, the project will analyse issues of trust in AI-mediated medical encounters with a particular emphasis on the gender dimension of such encounters and the dangers of silencing and testimonial injustice. Through interdisciplinary research and publications (seven articles and a journal special issue), high level academic engagements (a workshop, an international conference and a summer school) and targeted policy recommendations, FORSEE-HOP will add value to the existing project, FORSEE, while strengthening research capacity and output in the widening country of Armenia.

Keywords: trustworthy ai,environment,gender,healthcare,justice,llms
PHysically-Based Integrated Soil HEalth Simulation Platform (PHISHES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Denmark,France,Netherlands,Sweden,Germany,Czechia,Poland,Italy
Call: Soil pollution processes – modelling and inclusion in advanced digital decision-support tools (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 6090925.0
EU funding (EUR): 6090925.0
Participants: 9
Project status: SIGNED

PHISHES aims to bridge the missing link between data on soil health and actions for the safeguard of soils. This missing link entails predictive capability in terms of the consequences of actions on the provision of soil functions and associated ecosystem services, taking into account soil use, soil contamination and various drivers such as climate change. Hence the primary scientific question addressed in PHISHES is: “How do soil use and soil contamination influence soil functions and associated ecosystem services, in the presence of major drivers such as climate change, and how can we predict the impacts of mitigation and adaptation measures?”. While most research teams address this question in a qualitative / semi-quantitative fashion, using, e.g., multicriteria analysis and indicators of soil health, the ambition of PHISHES is to provide quantitative predictive capability via a PHISHES Digital Platform. To achieve this, PHISHES will build upon several pre-existing integrated simulation tools; in particular the MIKE SHE model that provides a flexible framework for integrated hydrologic modelling and the DAISY model, a well-tested mechanistic agro-ecological model of the soil-plant-atmosphere system. The efficient coupling between such models will significantly enhance the ability to assess the impact of changes in land use on soil ecosystem services. It will serve to assess the influence of various actions on soil services; i.e., sustainable agricultural practices (e.g., hedge rows to retain moisture and reduce erosion; no-till agriculture, crop rotation, ...), of land restoration / remediation solutions (e.g., nature-based solutions), pollution prevention solutions, etc. The results of the scenario simulations will be tranlated into recommendations regarding policies aimed at preserving soil health and promoting soil functions and associated ecostem services. The PHISHES consortium brings together competencies from soil science to hydrology and policy making.

Keywords: soil management and monitoring,scalable soil water atmosphere plant integrated modeling,decision support,soil resilience,pollutant mobility,climate change impacts,soil water management scenarios
Probing the role of miRNAs in cluster root development in white lupin (LUMIROOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Phosphorus (P) is an essential macronutrient for the production of food crops and the demand for P fertilizer is increasing worldwide. Earth's P is being depleted at an alarming rate urging the need for alternative strategies in order to maximize the availability of agronomic resources, optimize crop yields and guarantee food security with less impact on our environment. White lupin is the only crop that can form specific organs constituted by numerous short lateral roots, the so-called cluster roots (CRs), as an adaptation to low P availability in the soil, allowing an efficient acquisition of this nutrient, which is fundamental for plant growth and development. Remarkable advances have been made over the last years in identifying numerous genes involved in different facets of root adaptation to the environment and is known that microRNAs play a pivotal role in regulating gene expression during development and in response to environmental cues. The main objective of LUMIROOT is to elucidate the miRNA-dependent mechanisms regulating the formation of CRs in white lupin contributing to optimize plant resource acquisition based on the already proven role of miRNAs in root developmental processes. I will focus on these networks based not only on their functional importance but also on the broader interest of regulatory pathways controlling the development CRs. I will in deep functionally analyze the role miR396/target genes modules in CR development and reveal novel miRNA regulatory networks acting in CR formation and function. I also aim to develop miRNA-based nanoparticles to modulate in vivo miR396 action, as well as other regulatory miRNA/target networks to assess its potential to improve relevant agronomic traits such as CRs formation. LUMIROOT project will allow opening the way to crop improvement reducing the need for P fertilizers and will help to select regulatory networks with potential use in the improvement of relevant agronomic traits.

Keywords: plant regulatory rnas,mirnas,white lupin,root plasticity,regulatory networks,cluster roots,nanoparticles,post transcriptional regulation,root growth and development,phosphate starvation
Design Proton-Conducting Metal Organic Frameworks based membranes for Proton Exchange Membrane Fuel Cell Applications (MOF-PEMs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-09-30
Duration (months): 25.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

Proton exchange membrane fuel cells (PEMFCs), converting chemical fuels into electricity, are a promising electrochemical technology for the sustainable energy production using clean energy sources, thus, addressing the global challenge of energy demand and pollution control. However, drawbacks of the current polymer electrolyte materials (i.e, degradation and efficiency) limit their application. Metal-Organic Frameworks (MOFs), a class of hybrid porous materials, have recently found potential applicability in this emerging cross-disciplinary energy area. MOF-PEMs project aims to prepare new cost effective MOF-based membranes gathering good stability, and high proton conductivity over wide range of humidity and temperature conditions, supported by theoretical calculations toward understanding their proton-conducting pathways, which is an important step to industrially efficient PEMFCs. MOF-PEMs will, thus, overtake the current bottleneck of most commercial PEMs, by developing new electrolyte materials with high proton conductivity comparable or even surpassing Nafion® and affordable price, filling the gap between basic research and marketable applications. Key opportunities envisioned from MOF-PEMs include mitigation CO2 emissions and alternative sustainable energy-conversion and energy storage systems that are reliable, low-cost and environmentally friendly. We believe that the results of MOF-PEMs will attract large industrial interest derived by the need of society and governments for continued energy supply associated with rapid population growth.

Keywords: metal organic frameworks mofs,proton conductivity,mixed matrix membranes mmms,proton exchange membranes pems,proton exchange membrane fuel cells pemfcs,clean energy,phosphonate based mof
Role of Mitochondria-Associated ER membranes on microglia activation: implications for Alzheimer's disease. (INFLAMAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

Alzheimer’s disease (AD) is an irreversible neurodegenerative condition affecting 50 million people worldwide. Despite intense research, the pathological mechanisms of AD are still unclear. Many genetic loci robustly associated with AD code for proteins that are preferentially or exclusively expressed in microglia, supporting a causal role of microglia as key players in disease initiation and progression. Microglia are brain-resident immune cells that, upon activation, reorganize their cellular membranes by coordinating a network of lipid pathways at unique subcellular regions localized in the endoplasmic reticulum, called MAMs (Mitochondria-associated ER membranes), the membrane contact site between ER and mitochondria. Hyperactivation of MAM is shown to be associated with AD pathogenesis, however, the impact of MAM alteration on microglia biology is unexplored. The main objective of INFLAMAM is to determine the mechanism by which MAM regulates microglia activation, and the impact of defects in MAM and lipid homeostasis in the context of AD. To that aim, we propose to combine cutting-edge lipidomics and proteomics approaches with pharmacological and genetic MAM intervention strategies to identify relevant molecular drivers that enable the crosstalk between lipid metabolism and immune signaling at MAM in microglia. By proving the role of MAM as an immunometabolic hub for inflammation and a driver of AD pathogenesis, we believe this innovative project has the potential to pinpoint relevant lipid pathways as new targets for pharmacological intervention to alleviate the symptomatology related to microglia in AD.

Keywords: mitochondria associated er membranes,lipid metabolism,microglia,inflammation,alzheimer s disease
Efficient Verification of Quantum computing architectures with Bosons (VeriQuB)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: France,Sweden,Italy,Portugal
Call: EIC Pathfinder Challenge: Alternative approaches to Quantum Information Processing, Communication, and Sensing (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 4475201.25
EU funding (EUR): 4475201.25
Participants: 6
Project status: SIGNED

Quantum devices offer great promise for computation, cryptography, communication, and sensing. Alternative approaches to quantum information processing in which bosonic modes are the carriers of information have attracted increasing attention, because they offer a hardware-efficient path to fault-tolerance and scalability thanks to their inherently large Hilbert space. However, this poses the problem of providing rigorous guarantees of the correct functioning of these promising bosonic architectures, a task known as quantum verification. To date, this verification is performed by general-purpose tomographic techniques, which rapidly become intractable for large quantum systems. Thus, other methods are needed as quantum devices are scaled up to achieve real-world advantages. VeriQuB will introduce a new approach to the verification of quantum computing architectures with bosons based on continuous-variable measurements. VeriQuB’s technological toolbox will comprise two main elements. (i) We will experimentally demonstrate the verification of multi-mode bosonic systems for optical and superconducting architectures well beyond the state-of-the-art, and provide the first demonstration of verified quantum computational speedup. (ii) We will develop a theory framework that defines the fundamental advantages of our contribution, putting special emphasis on identifying and verifying resourceful bosonic quantum devices. The VeriQuB consortium comprises world leading scientific partners who are ideally positioned to achieve the ambitious vision of this project and build a state-of-the-art verification technology toolbox, enabling bosonic quantum computing architectures to scale up, and positioning Europe as a leader in this domain.

Keywords: quantum verification and certification bosonic quantum computing circuit qed quantum optics quantum resource theory continuous variable quantum information quantum computational speedup
Interactive Tools for the Study and the Enhancement of Music Iconography (In-Music)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

While music is undoubtedly a primary expression of any civilization, Western society seems to have moved further and further away from the music of its past, thus missing a great wealth of its own identity. Rethinking how we approach historical music is essential to bridge this gap and IN-MUSIC intends to make an innovative contribution in this direction. The project will focus on a particularly interesting yet little-addressed branch of cultural heritage, music iconography, addressing it through a multidisciplinary approach that combines iconological methodology with the application of digital technologies. Due to the very nature of music iconography, digital technologies represent a tool with enormous potential for both its study and enhancement. In fact, only in a virtual context is it possible to reconstruct the original ideal multi-sensory nature of musical images while digital means allow the socialization of highly specialized music-related contents in a dynamic and engaging way. Nonetheless, little has been done to fully explore this potential, especially in terms of interactivity. IN-MUSIC will address Early Modern Spain music iconography and will delve into different digital approaches and communication strategies, in order to devise replicable and versatile instruments. A semantic database, based on CIDOC-CRM, and a set of prototypes of digital devices will be elaborated, resorting to the use of different open-source software. All the prototypes will be submitted to different targets of public who will be asked to fill out a specifically designed survey to collect useful data for the evaluation of the effectiveness of such tools in communicating knowledge. The success of the action will therefore increase our knowledge on Spanish musical imaginary in a crucial historic context while providing scholars and cultural stakeholders with efficient means to study, teaching, and enhance an unconventional heritage.

Keywords: music iconography digital humanities digital heritage music iconology interactivity museology heritage communication virtual technologies