Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DAHDAC project: Disruptive Approach to Highly Distributed Application Creation (DAHDAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The DAHDAC proposer is Pro Gamma, an Italian SME whose unique business is the creation and commercialization of a software development tool based on the Model Driven Development (MDD) paradigm. This business opportunity addresses the problem that, globally, there is a lack of suitable tools that combine the MDD approach with mobile, cloud, social, and big data. In 2013 Pro Gamma started developing a prototype named C1B8 that perfectly addresses this business need. C1B8 offers a very promising glimpse of a completely innovative product that could be introduced to the market with further investment. C1B8 addresses the need to create state-of-the-art, highly distributed applications in much shorter time scales compared to the tools currently available, but without requiring staff who have specific technical knowledge. Some of the most innovative C1B8 features are: natively web-based, natively cloud-based, development on mobile devices, revolutionary social features, telecollaboration in real time and a disruptive approach to analytics. Furthermore C1B8 is built on relational programming techniques, in which application code is no longer written in text files, but rather generated via a graph of relationships. The objective of the DAHDAC project is a feasibility study that addresses the completion of the C1B8 prototype through to its development and commercialization in the main European and US markets. The Feasibility Study will include a market analysis, requirements validation, resources definition, marketing strategy identification, business and operation plan formulation and IPR-related issue definition. The target market consists of an audience of approximately 20,000,000 programmers worldwide. Pro Gamma has developed a promising market analysis that shows the achievement of 500,000 cloud programmers and 3,000 license-holding software companies in 4 years as a reasonable objective. If the DAHDAC project confirms the C1B8 potential, Pro Gamma will begin phase 2.

Keywords: highly distributed applications development,model driven development,mobile,cloud,social,big data,relational programming,node js,cloud based ide,remote dom technology,canvas ui
Shaping Interdisciplinary Practices in Europe (SHAPE-ID)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Italy,Ireland,Switzerland,Poland,Netherlands,United Kingdom
Call: Taking lessons from the practices of interdisciplinarity in Europe (H2020-SC6-GOVERNANCE-2018, 2018)
Start date: 2019-02-01
End date: 2021-10-31
Duration (months): 33.0
Total project cost (EUR): 1499887.59
EU funding (EUR): 1499887.59
Participants: 6
Project status: CLOSED

A multitude of existing reports and assessments of AHSS (Arts, Humanities and Social Science) integration have made recommendations as to how best to encourage interdisciplinarity. However despite the existence of these reports much of their individual advice and recommendations have not been fully taken up. It is the overall aim of this project to provide concrete guidance and practical recommendations (in the form of a toolkit) for shaping future action, moving beyond expressions of intent or encouragement and into a framework for efficiently achieving the best value from activities in the interdisciplinary space. These recommendations will cover aspects such as the structure of IDR practices at the level of a research institution, the role of networks and consortia at an international level and the enabling structures such as programmes operated by research funders including national, pan-European and private research foundations. The toolkit will be an aid to the stakeholder groups being targeted by this project in achieving successful pathways to integration. These stakeholders have been grouped under 4 broad headings: 1. European Research Area (ERA) -Policy Makers and Funders (both national research funding agencies but also non governmental funders such as the Wellcome Trust, Leverhulme Foundation, the The Andrew W. Mellon Foundation) 2. Researchers (from across the AHSS and STEM disciplines both those engaging in IDR projects and those working in monodisciplinary cultures) 3. Research Performing Organisations (i.e. Universities, Academies of Sciences, Enterprise) 4. Research Users (Enterprise, Civil Society, the cultural sector and the citizen) The project will enable comparisons of IDR practices and results with reference to enhancing approaches to scholarship and to elaborating solutions for key Societal Challenges.

Keywords: promotion of interdisciplinary research,transdisciplinarity,arts,humanities and social sciences integration,research and innovation policy,research and innovation studies,research evaluation
Polychromatic digital optics for structured light (BB-SLM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The development of photonics technologies implies ever-increasing agile optical components operating enabling the manipulation of the spatial degrees of freedom of light over broad spectral ranges. To date, spatial light modulators is a class of digital optical devices offering versatile management of light, however, state-of-the-art devices are operating efficiently only at a given wavelength. Here we propose to develop a digitally controlled spatial light modulator combining efficiency with intrinsically broadband behavior spanning the whole visible spectrum. This will be accomplished by integrating the advantage of spin controlled achromatic geometric Berry phase with broadband polarization-dependent circular Bragg reflection from spatially modulated chiral liquid crystals. Despite more than a century-long history of liquid crystals, the first report on the accumulation of Berry phase due to Bragg reflection came only very recently from the research group lead by the host scientist. The proposed two-year project to develop spatial light-modulators based on this basic physical principle. By doing so, we aim at controlling the interaction between the polarization state of light with its spatial degrees of freedoms (i.e., the spin-orbit interaction of light) by exploiting the inherently robust and diverse topological structures that spontaneously appear in anisotropic soft condensed matter systems such as liquid crystals. In particular, we will take advantage of both the self-organization orientational processes occurring in liquid crystals and their extreme sensitivity to external fields. By implementing a recently demonstrated physical concepts into a novel generation of spin-orbit optical devices enabling spatial control of the optical phase over a broad spectral range, this project will offer further possible applications for advanced photonic technologies, for instance in optical data processing, optical imaging and optical manipulation.

Keywords: spatial light modulators,geometric phase,liquid crystal,spin orbit interaction of light
Enabling CLoud Orchestration, Performance and Cost Efficiency Tools for QoE Enhancement and Provider Ranking (CloudPerfect)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Greece,Greece,France,United Kingdom,United Kingdom
Call: Cloud Computing (H2020-ICT-2016-1, 2016)
Start date: 2016-12-01
End date: 2018-11-30
Duration (months): 24.0
Total project cost (EUR): 2923375.0
EU funding (EUR): 2309237.5
Participants: 9
Project status: CLOSED

Cloud environments are notorious for their lack of stability in performance characteristics, a feature that makes it extremely difficult for owners of time-critical applications to make the decisive step for migration and owners of SaaS to be unable to present performance vs cost tradeoffs to their customers when acting as IaaS customers. CLOUDPERFECT aims at delivering a set of tools and processes that will enable a) Cloud providers to enhance the stability and performance effectiveness of their infrastructures, through modelling/understanding of the overheads, optimal groupings of concurrently running services, runtime analysis and adaptation, thus gaining a competitive advantage b) Cloud adopters to understand the computational nature of their applications, investigate abstracted and understandable QoS metrics for providers ranking, minimize the time of procurement and provider selection processes, automate deployment and orchestration processes, balance their selection between cost and performance to optimize their competitiveness, define according SLA levels (if on the SaaS level) and monitor the maintenance of their SLA c) 3rd parties to act as independent validators of Cloud QoS features, through a constant monitoring, benchmarking and evaluation process, filling a gap in the current brokerage/consultancy domain for performance evaluation and SLA auditing. The innovation action starts from mature existing prototypes derived from previous EC funded projects and aims at extending their TRL levels in order to support a spin-off entity to be created for the role of QoE Assessment Broker and Toolkit Consultant. The project will cover extensive experimentation with relation to the applicability of the envisioned toolkits in 4 facilities, while focusing on two heavy-weight industrial cases such as CFD and ERP/CRM, for which the overall value chain has been represented in the consortium, targeting domains such as manufacturing and telecom.

Keywords: cloud selection,cloud trust,cloud quality of experience,cloud business models,application migration,application profiling,performance benchmarking,automatic deployment
I3 Impact Innovate Invest (I3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Italy,Belgium,United Kingdom
Call: Technologies for creative industries, social media and convergence (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-09-30
Duration (months): 33.0
Total project cost (EUR): 986750.0
EU funding (EUR): 986750.0
Participants: 5
Project status: CLOSED

The I3 Impact Innovation Invest is a 33 months CSA that addresses the topic ICT 19 -2015 Technologies for creative industries topic c) Coordination and Support Actions on Convergence and Social Media. I3 will support research results from lab to market making innovation happen. I3 will promote a closer relation between researchers and entrepreneur providing mentorship and tutorship support to researchers and providing access to business angels and investors. The objective is to identify the emerging promising solutions and their feasibility in the Convergence and social media sector within the European research ecosystem. I3 aims to connect them with investors, corporates, institutions and media and with Startup Europe Initiative, in order to help them in accessing the market through selected events and exploitation activities. Living Lab approach will be used to allow business ideas and new technologies to be validated with users and community. I3 will implement a systematic policy review and analysis, applying methods that can effectively be used to solve issues in the domain addressed by the specific ICT19 topic, applying data and evidence methods. A Policy dialogue will be run to identify areas in need of further exploration, in order to advance consensus and bring together key stakeholders from public and private sector, civil society, academia and the media to discuss key policy issues. The dialogues will provide a forum for multi-directional dialogue, strategic coordination for the development of new research agendas, issues on regulatory framework and coordination of policies in Convergence and Social media. I3 will be dedicated to increase the projects outreach and impact bridging the gap between the technologies developed and the access to the market, increasing cooperation within the convergence social media ecosystem and liaising with related Innovation and R&D programmes both at the European international and national levels.

Keywords: innovation,startup,policy,livinglab,socilamedia
Smart ELECTrodeposited Alloys for environmentally sustainable applications: from advanced protective coatings to micro/nano-robotic platforms (SELECTA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Italy,Austria,Spain,Switzerland,Serbia,Greece,Lithuania,Sweden,Hungary,Netherlands,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3274969.68
EU funding (EUR): 3274969.6799999997
Participants: 16
Project status: CLOSED

SELECTA is a highly inter-disciplinary initiative which has the primary goal of training young researchers in the field of smart electrodeposited metallic alloys suitable for environmental / sustainable development applications. The Network encompasses the fabrication and in-depth characterization of: (i) innovative protective coatings, (ii) resilient micro/nano-electromechanical systems, and (iii) wirelessly actuated micro/nano-robotic platforms for cutting-edge environmental applications. The project will explore new types of electrodeposited alloys (based on Fe, Cu or Al; free from hazardous and scarce raw elements), with tunable structure (amorphous, nanocrystalline), morphology (dense, nanoporous) and geometry (films, micropillars, nanowires), to meet specific technological demands (high wear/corrosion resistance, superior magnetic properties or hydrophobicity). SELECTA aims to integrate technological progress with environmental sustainability concerns, which is one of the major “Societal Challenges” listed in the Horizon 2020 Work Programme. Several disciplines (Physics, Electrochemistry, Engineering, Environmental Sciences, Biology and Robotics) converge together to provide a holistic approach to accomplish the SELECTA goals. The project brings together 10 Beneficiaries and 7 Partner Organizations (including 5 private companies), belonging to 10 EU Member States (plus Switzerland and Serbia). Special efforts will be devoted to bridge fundamental science with commercialisation of the research outcome. The complementarities among partners will render a high-level, multi-faceted educational programme. World-class research will be combined with unique training opportunities in soft skills, such as career planning, dissemination, intellectual property rights, entrepreneurship or management. The Network aims to provide highly-qualified specialists able to face future professional challenges in either Academia or Industry in an independent manner.

Keywords: green electrodeposition,sustainable coatings,amorphous alloys,nanocrystalline alloys,corrosion,environmental healing,lithography,micro,nano electromechanical systems,nano robots
High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator (CF_struct)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-16
End date: 2018-11-15
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

This proposal seeks to solve the high-resolution X-ray crystal structure of full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an anion channel which regulates chloride ion concentration at the lumen-exposed surface of epithelial cells. Mutations of the CFTR gene cause cystic fibrosis (CF), a lethal disease which results in bowel obstruction, lung disease and premature death. CFTR is an ATPase and a member of the ATP-Binding Cassette (ABC) transporter family of proteins which has an allosteric Regulatory (R) domain not found in other ABC transporters. From the structure of CFTR, its mode of action will be revealed, focusing on the two sites of ATP hydrolysis and key residues for channel gating. CFTR will be crystallized alone and in the presence of the pharmacological agent Kalydeco, a small molecule from Vertex Pharmaceuticals that is used for the treatment of CF and reduces CF symptoms. The initial high-resolution X-ray crystal structure is a foundation from which personalized drug design work can begin. Therefore, the Kalydeco-CFTR complex structure will be used for ligand optimization of Kalydeco, an iterative process which will improve Kalydeco’s specificity and pharmacokinetics. The latest technology, including in meso in situ serial crystallography and X-ray free electron lasers for serial femtosecond crystallography will be used as well as traditional synchrotron X-ray sources. These Actions use an interdisciplinary mix of crystallography, chemistry, biochemistry, biophysics and computational structural determination programs. The work will take place in Ireland in the lab of Dr. Martin Caffrey at Trinity College Dublin, a distinguished researcher in the field of membrane structural and functional biology. The prestigious Marie Skłodowska-Curie fellowship will enable the candidate to actualize many objectives outlined in her career development plan in order to become an independent researcher.

Keywords: cystic fibrosis transmembrane conductance regulator,atp binding cassette,atpase,xray crystallography,membrane protein,hydrolysis,in meso,structure based drug design
Novel mitochondria-targeted therapies for cancer treatment-induced cardiotoxicity (MATRIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1999375.0
EU funding (EUR): 1473437.5
Participants: 2
Project status: SIGNED

Cardiac toxicity is one of the most frequent serious side effects of cancer therapy, affecting up to 30% of treated patients. Cancer treatment-induced cardiotoxicity (CTiCT) can result in severe heart failure. The trade-off between cancer and chronic heart failure is an immense personal burden with physical and psychological consequences. Current therapies for CTiCT are suboptimal, featuring poor early detection algorithms and nonspecific heart failure treatments. Based on our recently published results and additional preliminary data presented here, we propose that CTiCT is associated with altered mitochondrial dynamics, triggering a cardiomyocyte metabolic reprogramming. MATRIX represents a holistic approach to tackling mitochondrial dysfunction in CTiCT. Our hypothesis is that reverting metabolic reprogramming by shifting mitochondrial substrate utilization could represent a new paradigm in the treatment of early-stage CTiCT. By refining a novel imaging-based algorithm recently developed in our group, we will achieve very early detection of myocardial damage in patients treated with commonly prescribed cancer therapies, long before clinically used parameters become abnormal. Such early detection, not available currently, is crucial for implementation of early therapies. We also hypothesize that in end-stage CTiCT, mitochondrial dysfunction has passed a no-return point, and the failing heart will only be rescued by a strategy to replenish the myocardium with fresh healthy mitochondria. This will be achieved with a radical new therapeutic option: in-vivo mitochondrial transplantation. The MATRIX project has broad translational potential, including a new therapeutic approach to a clinically relevant condition, the development of technology for early diagnosis, and advances in knowledge of basic disease mechanisms.

Keywords: heart failure,cardiotoxicity,cardio oncology,myocardium,therapies