Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modes of genome evolution during major metazoan transitions (METASCALE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1483477.0
EU funding (EUR): 1483477.0
Participants: 1
Project status: SIGNED

Our understanding of how genomic changes translate into organismal novelties is often confounded by the complexity of the underlying genome architecture. My previous studies revealed a complex interplay between several levels of genomic organization during major metazoan evolutionary transitions, ranging from modifications of regulatory elements to the gene order on the chromosomal scale. A major gap in our understanding is the extent to which those different genomic scales are evolutionarily linked and reflect an inherent functional property or mode of genome evolution. In this proposal, I focus on the emerging model system within the highly advanced clade of cephalopod molluscs, the Hawaiian bobtail squid Euprymna scolopes, to study how changes in the mode of metazoan genome evolution have yielded unique cephalopod innovations (e.g., the largest invertebrate brain). To address this question, I will (1) take a novel global pan-metazoan comparative genomics approach to test and reveal the extent of genomic character co-evolution, identifying, for the first time, modes of genome evolution. I will then (2) test whether co-evolving characters form inherent regulatory units in metazoan genomes by an in-depth characterization using emerging and available regulatory genomic data. Finally, using latest molecular approaches, I will (3) study the regulatory composition of co-evolving character units associated with cephalopod brain development and functionally test their organismal impact. This proposal will develop a novel and holistic approach to study genome evolution, constituting a departure from the previous analyses based on individual genomic characters. It will link genomic evolutionary units to their function, revealing the genomic changes behind major innovations (cephalopod brain). Finally, this project will develop predictive models that use evolutionary data to identify novel regulatory units aiding both biological and biomedical applications.

Keywords: cephalopods,genomics
Tracing the Ontogenetic Evolution of Diet and Behavior in Neandertals and Anatomically Modern Humans in the Franco-Cantabrian Region. An Integrative study of 3D Tooth Wear Patterns (3DFOSSILDIET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: SIGNED

3DFOSSILDIET (Tracing the Ontogenetic Evolution of Diet and Behavior in Neandertals and Anatomically Modern Humans in the Franco-Cantabrian Region. An Integrative study of 3D Tooth Wear Patterns), aims to reconstruct both dietary patterns and biomechanics of the masticatory apparatus during ontogeny (somatic development and growth of an organism throughout its lifetime, from conception to adulthood, a span known as the Life History) in Neandertals and Anatomically Modern Humans in order to trace trophic variation and behavioral complexity, and the following questions will be addressed: 1) How did adult individuals care for sub-adults? 2) How did sub-adults become independent individuals? 3) How were relationships expressed within the groups? 4) Could social patterns reflect our evolutionary success? This project will implement the use of recently developed virtual methods (Dental Microwear Texture Analysis and Dental Topographic Analysis) for the analysis of both micro- and macro- dental wear patterns in both Neandertals and Anatomically Modern Humans as a proxy to infer biomechanics of the mastication (diet) and general use of the mouth (behavior) along the Life History of both human species. 3DFOSSILDIET is interdisciplinary, bringing together expertise in microscopy, bioarchaeology, isotopic analyses, and paleoanthropology through an integrative methodology to document dental wear. The results will address how and if behavioral changes were reflected across the human groups who lived during Middle to Upper Paleolithic Transition at the Franco-Cantabrian Region. Furthermore, the advance of the study of dental wear will provide technological framework for the study of surface modifications of both biological and archaeological materials.

Keywords: homo neanderthalensis,homo sapiens,dental wear patterns,dental biomechanics,ontogeny
ZIKAction: Preparedness, research and action network on maternal-paediatric axis of ZIKV infection in Latin America and the Caribbean (ZIKAction)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Argentina,Jamaica,United States,Brazil,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Addressing the urgent research gaps against the Zika virus and other emerging threats in Latin America (H2020-SC1-2016-RTD-Zika, 2016)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 6916081.25
EU funding (EUR): 6916081.25
Participants: 15
Project status: CLOSED

ZIKAction proposes to set up a multidisciplinary research network across Latin America with a focus on maternal and child health to coordinate and implement urgent research against the current ZIKV outbreak and lay the foundation for a preparedness research network against future emerging severe infectious threats in these vulnerable populations. Our Consortium brings together Latin American and European leaders in paediatric infectious disease research, including virologists, epidemiologists, immunologists and obstetric, neonatal and paediatric practitioners, all with a wealth of experience in vertical transmission (VT) studies, a group uniquely placed to evaluate the potentially causative relationship between ZIKV and severe reported complications. ZIKAction will collect data from prospective cohorts of pregnant women and infants to assess ZIKV complications with the necessary level of evidence which is currently lacking. Complementary work in virology will take advantage of repeated biological samples from these cohorts, while pathogenesis studies on animal models will elucidate risk factors and mechanisms of VT. Partners’ experience in conducting trials among pregnant women and children and close contact with other relevant researchers will allow rapid launch of additional interventional studies, including the addition of sites and partners, to address remaining research gaps against ZIKV. Recognizing the breadth and complexity of the research questions presented by the current ZIKV epidemic and the potential for future severe emerging infectious threats, ZIKAction will actively seek out collaborations with relevant initiatives already existing or under development to maximize synergy and avoid duplication of efforts. Our focus on vertical transmission and maternal and child health would nicely complement a range of other activities including clinical and laboratory studies in the general population, surveillance, and work in public health and prevention.

Keywords: paediatric neonatal maternal pathology diagnostics immunology preparedness vertical transmission congenital infection natural history harmonization data sharing networking animal models pregnancy
Digital Ontology-based Modelling Environment for Simulation of materials (SimDOME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Italy,Germany,Italy,Italy,Belgium,United Kingdom
Call: Accelerating the uptake of materials modelling software (IA) (H2020-NMBP-TO-IND-2018, 2018)
Start date: 2019-01-01
End date: 2023-01-31
Duration (months): 49.0
Total project cost (EUR): 4577565.0
EU funding (EUR): 3941630.26
Participants: 6
Project status: CLOSED

SimDOME aims to develop an industry-ready software framework for materials modelling interoperability, based on EU/EMMC standards on materials modelling, by combining, further developing and adapting existing software developed within previous EU FP7-NMP projects SimPhoNy and MoDeNa, the H2020-NMBP project NanoDome and the FP7 ERC-AdG STRATUS. SimDOME achieves the highest level of interoperability through the standardization of the material users case (i.e. the material/process to be simulated, according to EMMC definitions) that are provided within the SimDOME framework by means of the European Materials Modelling Ontology (EMMO). User case standardization will allow data communications between software by translating the concept of each specific implementation to the standard unified concepts and interfaces provided by the ontology. The framework will provide also ready-to-use modules that cover different industrial applications and materials modelling fields spanning through multiple scales. The demonstration of the exploitation potential of the framework will be done within project by testing the SimDOME framework prototype and each integrated modelling software in their respective industrial operational environments (TRL 7) in the fields of gas and liquid phase material synthesis, molecule characterization and chemical kinetics. SimDome will integrate and provide the upscaled software and services for maintenance and support via the existing and future European Materials Modelling Marketplace (EMMM), the network of modelling translation environments and the Open Innovation modelling test beds. A strong relation with the EMMC, EMMM and existing projects is guaranteed by the fact that most of the SimDOME proponents are active members of the EMMC, leading the EMMO development and partners of existing H2020 Modelling Marketplace projects.

Keywords: materials modelling,interoperability,ontology,simulation
Tracking Information in Quantum Networks (TITAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Singapore
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2024-07-31
Duration (months): 36.0
Total project cost (EUR): 262948.8
EU funding (EUR): 262948.8
Participants: 2
Project status: SIGNED

Recent technological advances allow to build revolutionary devices for information processing by making use of quantum mechanics. Most strikingly, quantum communication allows to transmit information with physical security guarantees and quantum algorithms solve problems that are otherwise computationally unfeasible. Having such quantum technologies in sight, it becomes imperative to investigate what can be achieved in practice but also what the ultimate limitations are. Since both questions are fundamentally concerned with processing information, it is natural to seek an information theoretic approach to find an answer. Entropy inequalities are among the most important tools in the theory of classical and quantum information processing. They have been successfully applied to bound the information flow in classical information networks and to understand the inner workings of deep neural networks. However, in the quantum case our understanding of such inequalities is currently lacking. Most importantly, the quantum information community is missing a developed theory regarding conditioning on quantum systems. This fact hinders us in fully judging the potential impact of modern quantum technologies, since one is not able to effectively determine the properties of the underlying operations. I propose to set up a conceptually novel information-theoretic framework to quantify practical advantages of quantum-based devices for network communication and machine learning, by mitigating the quantum conditioning problem. I will develop entropic inequalities that describe the change of entropy under specific operations, in particular, quantum gates and channels that can be part of an encoding or decoding circuit for quantum communication, a quantum internet or act as nodes in a quantum neural network. I will develop a framework that allows to prove such entropy inequalities, on a unified basis and employ them to better understand these important technologies of the future.

Keywords: quantum information theory,entropy inequalities,quantum communication,quantum machine learning
FAR INFRARED RADIATION SMART FABRIC HEATING ELEMENT FOR CROPS’ ROOT ENVIRONMENT OPTIMIZATION IN GREENHOUSES (AgrowFab)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2022-03-31
Duration (months): 35.0
Total project cost (EUR): 1927557.5
EU funding (EUR): 1349290.25
Participants: 2
Project status: CLOSED

Greenhouse managers need to improve their crops productivity to guarantee food security. Heating crops roots is essential to obtain higher yields, but existing technologies fail to direct the energy to the crops, heating the whole greenhouse instead. This has a large cost in terms of energy consumption (up to 40% energy waste) and GHG emissions and promotes pest infestation. With AgrowFab, we aim to commercialize a cost-efficient and sustainable technology consisting on a smart fabric that radiates heat as Far Infrared radiation (FIR). The fabric is made from nylon fibres coated with a proprietary non-metal carbon compound, making them electrically conductive. Our product’s nature (lightweight and mechanically flexible) allows its application to surface of any kind/size, and, thanks to a powerful control algorithm, it can be combined with other smart management systems to simultaneously control heating, irrigation and fertilization cycles, therefore enabling the complete management of the root-zone environment. AgrowFab controls the root’s capacity to absorb oxygen, water and nutrients on-demand, enhancing crop yields by 35%, while minimizing the energy waste (at least 40% lower) through accurate and faster (35-45%) temperature delivery. It also decreases the pesticide use by 20% and it can be powered using renewable energy sources. Our consortium is formed by San Hitech Ltd. – a leading engineering company with >20-year-experience and a wholesale branch for industrial electrical supplies – and ThermoSiv Ltd. – a experienced manufacturer of smart heating fabrics – which have joined their engineering and commercial capabilities to bring AgrowFab to market. Through this project, we aim to boost the competitiveness of both companies, reaching cumulative revenues of €47 million after 5 years of commercialization, creating 35 new job positions. With a total Phase 2 investment of €1.9 million, this would imply a ROI of 3.91.

Keywords: smart heating,greenhouses,crops,pest infectation,nylon fibers,far infrared radiation,root environment,fertigation smart control,energy saving,crop production increase
Eliminating Uncertainty in Coronary Artery Disease (EU-CAD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 3572775.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Coronary artery disease (CAD) is a disease blocking blood flow to the heart. Identifying patients with limited blood flow is key in improving patient outcomes. 15O-water is the undisputed gold standard tracer for blood flow assessment, with more than 450 publications on the topic. However, the ultra-short half-life of 15O -water, the difficult image analysis and the lack of regulatory approved equipment have limited its use in clinical practice. This limits the transition from current practice (SPECT, with poor accuracy and low throughput) to PET. With MedTrace’s solution of hardware and analytical software, clinicians all over the world will get routine access to 15O-water PET, achieving unrivalled accuracy at a low-cost while increasing patients’ comfort. MedTrace’s addressable market potential draws on the installed base of current PET scanners (>500,000 worldwide in 2017), tapping into a multi-billion-euro opportunity for every 1% that starts using 15O-water. This market is even larger as we further build the evidence that 15O-water PET scans are safer and more cost-effective than current clinical practice. We are asking for grant funding to further mature our working prototype solution, validate it in a small cohort of patients in three different EU sites, and obtain CE approval to operate in Europe. We also ask for equity funding to scale in the US by conducting a phase III clinical trial for regulatory approval in the US. This will allow us to overcome all the remaining regulatory barriers and improve cardiac imaging worldwide.

Keywords: radioactive water,positron emission tomography,tracer,cardiac pet,quantitative imaging,quantitative blood perfusion,cardiac perfusion
In science we trust - scientists sound the alarm and show how to save the Earth! (SOSNIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-06-01
End date: 2022-03-31
Duration (months): 10.0
Total project cost (EUR): 102885.0
EU funding (EUR): 102885.0
Participants: 8
Project status: CLOSED

Within SOSNIGHT project our researchers sound the alarm and will demonstrate how science and scientists can save the planet. We want to show that although the Earth's climatic situation is very difficult, science offers hope to save it. This slogan "in science we trust" will be the main motto throughout the entire event. Its objective is to make public at large, and especially young people look at science as a source of strength, opportunities and hope for the future. During the event we will show how each field of science (technical, humanities, natural sciences, health sciences) can be a source of hope for saving the planet. The subject matter of the program will point to the importance of the European Green Deal for Europe and its citizens. See how to live in an eco-friendly manner every day, see what an ideal city of the future should look like, take a look at the plants that feed the world, learn to care for the ecosystem, find out how knowledge about trees can save lives, learn about environmentally friendly technologies. You will find that scientists are ordinary people and their work is truly fascinating. And all this thanks to science presented in a completely playful way (edutainment). The SOSNIGHT project is a continuation of projects from the last fourteen years, nevertheless presenting a lot of new things. Basing on the positive response from public during Researchers' Night in 2020 we want to include in this year's programme in addition to stationary events also online events, which sparked great interest in 2020. A significant advantage of the project will be its flexibility. We are able to modify the program and the way of organizing its events in response to changing situation in the world. Topics of individual Partners have been selected so that they are in keeping with the overall message of the project. We want to show that the work of scientists brings hope for the planet, and it is a lesson that is worth learning from them.

Keywords: researchers night,edutainment,environmentally friendly,research,awareness,care for ecosystem,save the planet,european green deal
Delivering affordable and sustainable housing in Europe (RE-DWELL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Spain,Cyprus,Croatia,Hungary,France,Netherlands,United Kingdom,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 3882470.4
EU funding (EUR): 3882470.4
Participants: 10
Project status: SIGNED

RE-DWELL will train a new generation of professionals with the transdisciplinary skills which are needed to address the urgent need of affordable and sustainable housing, a major challenge for European societies. To date, affordability and sustainability of housing have been addressed separately, from various disciplinary perspectives (e.g. architecture and planning, economics, sociology) and realms (e.g. policy-making, sustainable development, urban planning, green building). However, recent research indicate that it is necessary to consider the affordability and the sustainability of housing as complementary and interrelated aspects which need to be addressed with a transdisciplinary approach, by combining academic disciplines and engaging non-academic sectors in a common production of knowledge. Ten academic beneficiaries and twelve non-academic partner organisations will jointly contribute to creating a transdisciplinary research environment which encompasses the various disciplines, sectors and stakeholders involved in the provision of A&S housing. Fifteen ESRs research works will interlink three key areas underpinning affordable and sustainable housing: 1. Design, planning and building; 2. Community participation; and 3. Policy and financing. ESRs trained in this programme will be able to develop a capacity to operate across fields and sectors, to provide innovative solutions to the growing housing problem affecting our societies.

Keywords: sustainable housing,affordable housing,sustainable development,urban regeneration,cohousing,building energy efficiency,industrialized construction,right to the city,housing financing