Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Linking Epidemiology and Laboratory Research on Transboundary Animal Diseases and zoonoses in China and EU (LINKTADS)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Coordination and support actions
Countries involved: Italy,Hungary,United Kingdom,France,Sweden,China,Portugal
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-11-01
End date: 2016-10-31
Duration (months): 36.0
Total project cost (EUR): 1194585.0
EU funding (EUR): 999907.0
Participants: 11
Project status: CLOSED

The continuous growth of the world population translates into a demand of animal protein that can only be achieved through technological advances in farming, intensification, and expansion of farmed land. These pressures, combined with the increasing international trade of animals and their products, will lead to the rapid spread of animal diseases across borders and the emergence of new pathogens. This can have a huge impact on trade, livelihoods and public health. China is no exception and is in fact the world’s largest livestock producer and consumer, with pig and poultry meat being the most consumed meats. Research has many of the answers to prevent and control animal diseases, either through the understanding of their spread (epidemiology) or through better diagnostics for disease detection and surveillance. Both the European Union (EU) and China are two major worldwide players in animal health research. With dozens of institutions working on livestock health, the cross-border coordination and networking of research becomes a top priority to avoid duplication, while maximizing efforts by bringing together new ideas, expertise, technologies and funds. LinkTADs brings together world-class research institutes and experts in cross-border cooperation with the aim to coordinate research between the EU and China, thus improving scientific excellence in animal health (epidemiology and laboratory). Main objectives: • identify the priority areas, where joint actions are needed • link the research activities carried out on by European and Chinese research programmes • ensure a wide-range networking of scientific communities and stakeholders • provide a long term vision and achieve coordinated planning on future common research • contribute to the international policies of the EU • improve the research capacity of organizations by supporting young researchers through exchange programmes and training • share the results and methodologies within and outside the consortium.

Keywords: animal diseases,zoonoses,china,european union,networking
The melt stirring in AlMgSi alloys as the new technology of intermetallics treatment (IFLOWFEPHASE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-05-01
End date: 2018-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Aluminum-silicon base alloys are widely used in castings (foundry industry) due to their excellent castability and high strength-to-weight ratio. In the Al-Si alloys, the presence of small amounts of Fe and Mn brings about a complicated microstructure due to the formation of a rich variety of intermetallic phases (IMPs) during solidification, which generally have a negative effect on the mechanical and physical properties of a as cast part. The main goal of the project “iFlowFePhase” is to prepare new technology of Fe and Mn intermetallic phases treatment by fluid flow in Al-Mg-Si casting alloys. The project investigates problems of artificial fluid flow (melt stirring) influence on the growth, morphology and spatial arrangement of intermetallic phases in as-cast AlSi-base alloys containing especially Fe and Mn as alloying elements. Addition of Mg allows 3D visualization of IMPs, dendrites and eutectics. The “iFlowFePhase” studies concerns detailed tasks: solidification of casting specimens in MagFound facility by the presence of fluid flow and without it (in different solidification conditions), detailed analysis of the microstructure of the Al-Si alloys (dendritic pattern geometry, length, thickness, and density of IMPs, three dimensional morphology of IMPs, dendrites and eutectics), numerical modeling for physical understanding of the mechanisms leading to the anticipated changes in microstructure by the presence of IMPs and fluid flows. Project involves advanced unique facilities and modern scientific methods: solidification within MagFound, microstructure investigation by optical (Nikon) and SEM (Tescan) microscopes, x-ray Diffractometry (PANalytical Empyrean), metallography, quantitative image analysis (Multiscan, Image J), differential scanning calorimetry DSC (Netsch), yield tensile tester (Instron), x-Ray tomography (nanotom s GE). “iFlowFePhase” will be conducted in Institute of Materials Technology at the Poznan University of Technology in Poland.

Keywords: materials engineering,metal technology,al-si alloys,casting,intermetallic phases,fluid flow
NanoBioEngineering of BioInspired BioPolymers (NANO3BIO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Germany,Belgium,Spain,Sweden,France,Denmark,Germany,India,Germany,France,Denmark,Germany,France,Germany,Germany,Germany,Germany
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 11695705.2
EU funding (EUR): 8989324.0
Participants: 22
Project status: CLOSED

The Nano3Bio project convenes a consortium of world renowned experts from 8 EU universities, 1 large company, and 14 SME, to develop biotechnological production systems for nanoformulated chitosans. Chitosans, chitin-derived polysaccharides varying in their degree of polymerisation (DP), degree of acetylation (DA), and pattern of acetylation (PA), are among the most versatile and most promising biopolymers, with excellent physico-chemical and material properties, and a wide range of biological functionalities, but their economic potential is far from being exploited due to i) problems with reproducibility of biological activities as today’s chitosans are rather poorly defined mixtures, and ii) the threat of allergen contamination from their typical animal origin. The Nano3Bio project will overcome these hurdles to market entry and penetration by producing in vitro and in vivo defined oligo- and polymers with controlled, tailor-made DP, DA, and PA. Genes for chitin synthases, chitin deacetylases, and transglycosylating chitinases/chitosanases will be mined from different (meta)genomic sources and heterologously expressed, the recombinant enzymes characterized and optimized by protein engineering through rational design and molecular evolution, e.g. targeting engineered glycosynthases. These enzymes and genes will be used for in vitro and in vivo biosynthesis in microbial and microalgal systems, focusing on bacteria and diatoms. The bioinspired chitosans will be formulated into biomineralised hydrogels, nanoparticles, nanoscaffolds, etc., to impart novel properties, including by surface nano-imprinting, and will be bench-marked against their conventional counterparts in a variety of cell based assays and routine industrial tests for e.g. cosmetics and pharma markets. The process will be accompanied by comprehensive life cycle assessments including thorough legal landscaping, and by dissemination activities targeted to the scientific community and the general public.

Keywords: biopolymer,biosynthesis,chitosan,gamification,glycosynthase,legal landscaping,life cycle assessment,metabolic engineering,metagenomics,microalgae,molecular evolution,nanoformulation
Using Galaxy Surveys to Understand the Dark Universe (DARKSURVEY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Universe Sciences
Countries involved: United Kingdom
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-06-01
End date: 2018-07-31
Duration (months): 50.0
Total project cost (EUR): 1558948.91
EU funding (EUR): 1558948.91
Participants: 1
Project status: CLOSED

Galaxy Surveys are a key resource for observational cosmology, with the potential to provide the answers to many fundamental questions in modern physics. The Darksurvey project will use the Dark Energy Survey (DES) and extended-Baryon Oscillation Spectroscopic Survey (eBOSS) within which Will Percival has key leadership positions, and future projects including MS-DESI to measure the cosmological expansion rate between redshifts 0.5 and 2, testing Dark Energy. Complimentary structure growth measurements will test Einstein's theory of Gravity on the largest scales possible. The large-scale clustering of galaxies will be used to constrain primordial non-Gaussianity, testing and constraining models of inflation. The scale-dependence of the clustering signal will be used to measure the masses of neutrinos through their early Universe effects, and to set constraints on the evolution of galaxies and structure over cosmological time-scales. Parallel development of innovative tests and measurement methods will be undertaken to enable and enhance these results, while joint analysis with CMB and weak-lensing data will be used to perform additional tests, and to break degeneracies present when cosmological models are tested. This grant will consolidate the world-leading position of the group initiated by Will Percival at the University of Portsmouth, and developed over the last 4 years. Furthermore, it will train and develop a group of scientists within Europe with the key experimental skills required for the ESA Euclid mission.
Intelligent System Development Platform for Intelligent and Sustainable Society (IMPRESS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: International Cooperation
Action type: Collaborative project
Countries involved: Germany,Sweden,Denmark,Italy,Finland
Call:  (FP7-ICT-2013-EU-Brazil, 2013)
Start date: 2013-09-01
End date: 2016-03-31
Duration (months): 31.0
Total project cost (EUR): 1761355.0
EU funding (EUR): 1350000.0
Participants: 6
Project status: CLOSED

The aim of the IMPRESS project is to provide a Systems Development Platform which enables rapid and cost effective development of mixed criticality complex systems involving Internet of Things and Services (IoTS) and at the same time facilitates the interplay with users and external systems. The IMPRESS development platform will be usable for any system intended to embrace a smarter society. The demonstration and evaluation of the IMPRESS platform will focus on energy efficiency systems addressing the reduction of energy usage and CO2 footprint in public buildings, enhancing the intelligence of monitoring and control systems as well as stimulating user energy awareness. The IMPRESS project aims at solving the complexity of system development by providing a holistic approach that includes an Integrated Development Environment (IDE), middleware components, and a deployment tool. The main technical and scientific objectives of the IMPRESS project are: • Developing an Integrated Development Environment (IDE) to facilitate Model-Driven Development of Smarter Society Services. • Providing a Service-Oriented Middleware to support Mixed Criticality Applications on Resource-Constrained Platforms. • Developing easy-to-use and configurable tools for Cloud-based Data Analysis and Context Management. • Develop Network and Communication management solution to handle the heterogeneity of Internet of Things. • Creating efficient Deployment Tools for Internet of Things applications. The project will be deployed in the Teatro Amazonas Opera House as an attractive showcase to demonstrate the potential of a smart system for reducing energy usage and CO2 footprint in an existing public building. The IMPRESS platform re-uses and extends results from several existing EU projects on Internet of Things, middleware and energy efficiency and builds on Open Source platforms. The IMPRESS project is carried out by a consortium already experienced with successful EU-Brazil collaboration.

Keywords: service-oriented middleware for mixed critical applications,model-driven development
Design Principles of Ion Pairs in Organocatalysis – Elucidation of Structures, Intermediates and Stereoselection Modes as well as Assessment of Individual Interaction Contributions (IONPAIRSATCATALYSIS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Synthetic Chemistry and Materials
Countries involved: Germany
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-04-01
End date: 2019-03-31
Duration (months): 60.0
Total project cost (EUR): 1994685.0
EU funding (EUR): 1994685.0
Participants: 1
Project status: CLOSED

Ions are nearly omnipresent in chemistry and biochemistry. By providing the highest intermolecular interaction energies, ionic interactions have an extreme impact on molecular structures, which are the key to molecular functions. Experimentally determined structures of small contact ion pairs in solution are very rare and sometimes lacking in complete research fields. In addition, despite the amazing progress in theoretical and supramolecular chemistry, the subtle interplay of interactions in small organic ion pairs remains largely unknown. As a result design principles for small organic ion pairs in solution are not available. To solve this general problem there is an urgent and actual need of the synthetic community, because ion-pairing catalysis is the actual hot topic in asymmetric catalysis. There, new catalysts have to be screened with high effort in a black box mode and reviews state that structural and mechanistic studies will be an essential part of the further progress in the field. In previous projects spread over the fields of organometallic, bioorganic, supramolecular and medicinal chemistry as well as transition metal catalysis and organocatalysis, we gained special NMR expertise in the structure elucidation of ion pairs and reaction intermediates as well as the assessment of intermolecular interactions. Now in this project, nearly all of these various techniques and approaches will be combined in a new and so far unprecedented way and complemented by techniques used for protein ligand interactions and extreme low temperature measurements. With this unique combination, NMR approaches will be developed and applied to elucidate the structures of catalytically active ion pairs and their intermediates in solution and to dissect their intermolecular interactions. The resulting detailed design concept for small ion pairs in solution will revolutionize not only ion-pairing catalysis but all scientific fields working with organic ion pairs in solution.

Keywords: nmr spectroscopy,organocatalysis
Perceptual Cycles: Exploring and controlling the perceptual consequences of brain rhythms (P-CYCLES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: The Human Mind and its Complexity
Countries involved: France
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-09-01
End date: 2019-08-31
Duration (months): 60.0
Total project cost (EUR): 1860672.0
EU funding (EUR): 1860672.0
Participants: 1
Project status: CLOSED

Many current theories implicate brain oscillations in perception, attention, consciousness or memory. This, however, has one critical implication that is often overlooked in cognitive sciences: if a perceptual function relies on an oscillatory basis, then it should operate periodically, as a sequence of successive episodes or 'snapshots', with more or less favourable moments recurring at a well-defined periodicity. The present project aims to explore the validity and the consequences of this groundbreaking notion of "rhythmic perception". Whereas current research links perceptual functions to relatively slow changes of oscillatory amplitude, we propose to investigate the perceptual consequences of brain rhythms at the rapid time scale of the oscillatory cycle –the notion of "perceptual cycles". In work-package (WP) 1, we will explore the range of perceptual and cognitive operations that depend on oscillatory neural implementations, and reveal their cyclic behaviour. In WP2, we will relate these perceptual and cognitive cycles to the underlying neural activities by means of brain imaging techniques (EEG, fMRI, TMS); a key innovation is a proposed novel fMRI method to visualize the spatio-temporal propagation of perceptual cycles. In WP3, we will utilize this knowledge to control the power, frequency and phase of perceptual rhythms and thus dynamically manipulate, improve or prevent perception. In WP4, we will bridge the gap between lower- and higher-frequency perceptual cycles (from ~2 to ~100Hz) by experimental studies of cross-frequency coupling and computational models of visual information multiplexing. The project as a whole will characterize the rhythmic dynamics of perception, their neural basis and their functional implications, bringing us closer to understanding perception itself. The idea that sensory perception and cognition might follow a succession of snapshots rather than a continuous stream could spark a major transformation in cognitive sciences.

Keywords: visual perception,attention,psychophysics,eeg,fmri,tms,oscillations,brain rhythms,illusions,eye movements,travelling waves
Deciphering the code of gene regulation using massively parallel assays of designed sequence libraries (GENEREGULATION)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Genetics, Genomics, Bioinformatics and Systems Biology
Countries involved: Israel
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-03-01
End date: 2019-02-28
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Many gene expression changes that are associated with disease states have in turn been linked to changes in the genes’ regulatory regions. However, without a ‘regulatory code’ that informs us how DNA sequences determine expression levels, we cannot predict which sequence changes will affect expression, by how much, and by what mechanism. Here, we aim to arrive at a mechanistic and quantitative understanding of how expression levels are encoded in DNA sequence using a combined experimental and computational approach. To this end, we will construct libraries of >50,000 sequences, fuse them to fluorescent reporters, and genomically integrate them to yeast or human cells. We will then develop methods for accurately measuring, in parallel, the expression of each fused sequence within a single experiment, and for measuring the DNA binding state of each sequence at single cell resolution, resulting in ~1000-fold increase in the scale with which we can study the effect of sequence on expression. Notably, we will design our experimental system to be modular, allowing us to propose a highly ambitious yet realistic plan in which we will study the effect of sequence on (1) transcriptional and (2) post-transcriptional regulation; (3) Unravel the effect of genetic variation across human individuals on expression; (4) Quantify how cellular fitness depends on the expression level of individual endogenous genes; and (5) Construct a predictive model of the effect of DNA sequence on expression. Each of our libraries should provide novel insights into a different aspect of gene regulation, leading to new means by which we can interpret whole genome sequencing, which is rapidly being collected for many individuals. In particular, our unified model should allow us to predict expression changes among human individuals based only on their genotypic variation, greatly enhancing the ability to identify common or rare sequence variants that may affect molecular function or cause disease.

Keywords: functional genomics,transcriptional regulation,gene regulation,computational biology,gene expression
Exploiting the power of human induced pluripotent stem cells to generate synthetic retinae in vitro for cell based therapies, drug discovery and disease modelling (RET-IPSC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic Tools, Therapies and Public Health
Countries involved: United Kingdom
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-06-01
End date: 2018-05-31
Duration (months): 48.0
Total project cost (EUR): 1599857.0
EU funding (EUR): 1599857.0
Participants: 1
Project status: CLOSED

Blindness represents an increasing global problem with social and economic impacts both for the patients and society in general. Recent estimates indicate that the overall number of people with visual loss is 285 million globally, of whom 39 million are blind. In Europe, approximately 1 in 30 individuals experience sight loss and 75% of those are unemployed, a social burden which is anticipated to double by 2020 as the population of Europe ages. Diseases affecting the retina, the light sensitive extension of the central nervous system lining the back of the eye, account for approximately 26% of blindness. To date, there are no treatments to restore lost retinal cells and visual function and there is an urgent need for new therapeutic approaches. A pioneering breakthrough has highlighted the possibility of generating synthetic retinae from stem cells under laboratory conditions. This research is in its infancy and needs to be developed so human synthetic retinae can be produced efficiently and reproducibly from patient-specific stem cells. Very recently, my group has developed a unique method that results in conversion of human embryonic stem cells to fully laminated retinae containing all retinal cell types under laboratory conditions. In this project we aim: (1) to develop a robust differentiation method for generation of synthetic retinae that can be applied efficiently to a large number of patient-specific induced pluripotent stem cells; (2) to investigate that laboratory derived synthetic retinae contain functional retinal cells which are equivalent to native cells arising during human development and can contribute to restoration of vision upon transplantation into degenerate retinae and (3) to develop preclinical tools that will enable us to select functional retinal cells for cell replacement therapies in humans.

Keywords: human induced pluripotent stem cells,blindness,synthetic retina,human retinal development,retinal pigmented epithelium,photoreceptors