Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of new-to-nature reactions under the concept of synergistic catalysis through the design of novel cobalt-based artificial metalloenzymes. (Co-ARMs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2025-02-28
Duration (months): 30.0
Total project cost (EUR): 221135.38
EU funding (EUR): 221135.38
Participants: 1
Project status: CLOSED

Artificial metalloenzymes (ARMs), that is, designed enzymes containing a synthetic metal co-factor within a protein framework, locates itself as a promising area of research for the discovery and development of new transformations. We set our attention in cobalt complexes as co-factors, a first-row, earth-abundant, and non-toxic metal that is currently underexplored in ARMs. Cobalt complexes present a highly versatile chemistry, including they ability to participate in allylic functionalization reactions, an important transformation for the pharmaceutical industry as can deliver structural frameworks that are widely spread in biological active compounds. Allylic functionalization reactions are underdeveloped in bio-catalysis, and the expansion of important homogeneous reactions, as the before mentioned, into the realm of enzymes is an absolute necessity for the development of sustainable chemistry. Co-ARMs (Cobalt-containing ARtificial Metalloenzymes) proposal aims to create new generations of ARMs relying on the unique reactivity of synthetic cobalt complexes in allylic substitution reactions, an unknown reaction in enzyme catalysis and an underexplored metal for the discovery of new-to-nature reactions. The proposal balance between host expertise (Dr. Gerard Roelfes) in bio-inorganic and chemical biology, and the researchers’ skills (Dr. Franco Della-Felice) in synthetic organic chemistry. The result is a cooperative field where two different branches converge with the aim to develop new concepts and environmentally compatible tools in chemistry to access organic frameworks of high significance to the pharmaceutical and agrochemical industries.
Winds in galaxies (WINGS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1199519.0
EU funding (EUR): 1199519.0
Participants: 1
Project status: SIGNED

Massive black holes (BHs) reside at the center of galaxies and release an extraordinary amount of energy during their accretion phase. Such energy drives galaxy-scale gas outflows that can significantly influence the evolution of the host galaxy. Despite the remarkable theoretical and observational progress in quantifying the energetics and dynamics of such outflows, establishing their role during the formation and evolution of galaxies remains a long-standing problem in modern astrophysics. WINGS is designed to finally settle whether outflows driven by BHs are able to shape galaxies and their environment or not. To achieve this goal, we will build up a novel observational and theoretical framework that investigates the role of outflows in the early Universe, when BHs and galaxies are growing at the highest rates and outflows are expected to be more common and powerful, leaving a prominent mark on galaxy evolution. Thanks to the PI, WINGS will have access to several key observing programs carried out with ALMA and VLT as well as the guaranteed-time observer (GTO) program (~900 hours) with the NIRSpec spectrograph on board the soon-to-launch JWST. By exploiting both observations of local outflows and zoom-in simulations, we will develop a 3D kinematic outflow model that will be an asset in (i) interpreting existing high-redshift data and upcoming JWST observations, (ii) characterizing for the first time outflow properties across cosmic time (up to z~9), and (iii) identifying feedback signatures in the interstellar and circumgalactic medium properties. The combination of JWST, ALMA, and VLT observations will enable WINGS to assemble the largest high-spatial resolution survey of multi-phase outflows. The support from the ERC will be crucial to assemble a unique team mixing the observation-oriented and theory-oriented approach, as a joint effort of observations and simulations is the key to make a major breakthrough in understanding outflows driven by BHs.

Keywords: black holes,outflows,high redshift universe
The Benefits of Conflict: How Factions Can Enhance Political Parties' Electoral Performance (INTRAPARTY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2028-05-31
Duration (months): 69.0
Total project cost (EUR): 1496800.0
EU funding (EUR): 1496800.0
Participants: 1
Project status: SIGNED

Political parties and voters form important relationships in a democracy. The conventional wisdom is that divided parties lose elections. Yet the empirical evidence for this is ad hoc, and there are good reasons to suspect that it is, at best, a conditional wisdom. Firstly, the factional groups that divide parties vary in many different ways, even if the conventional wisdom treats them all the same. Secondly, since factions have somewhat different preferences than the rest of the party, they could also be useful in representing additional segments of society. However, there is currently no systematic analysis of the impact of factions – whether negative or positive – on a party’s electoral result. INTRAPARTY is a comparative study of factions and their effects on political parties’ electoral success in Europe. By answering the overall research question of When and how can factions have positive effects on political parties’ electoral performance?, INTRAPARTY launches a new scientific inquiry that challenges the conventional wisdom and seeks to explain the positive effects of factions on parties’ electoral performance. It provides unprecedented theoretical and empirical insights into the true role of factions in representative democracies. The project elaborates an original theory explaining factional effects on parties’ electoral performance that accounts for the inherent balancing factions face between inducing pressure but not harm on their party. Factions constitute a source of representation and reputation to voters that was previously neglected. Empirically, the project breaks new ground by combining theory-testing and exploratory approaches from research in party politics, interest group, and computational social sciences. By constructing an original comparative dataset on factions and parties over time and designing creative survey experiments to test voters’ reactions, the project tests the effects of factions on parties’ electoral success in Europe.

Keywords: political parties factions elections public opinion exploratory and theory testing methods europe
Optical scattering analysis for the determination of the physicochemical properties of blood clots (ECLIPSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Venous thromboembolism (VTE) is a common and serious disease in which a blood clot forms in the venous system. When a blood clot forms in the deep veins of the leg (deep vein thrombosis, DVT) and migrates through the bloodstream, to lung arteries, it creates a pulmonary embolism (PE). VTE encompasses DVT and PE and causes more than 30000 annual deaths in Europe. After clinical investigation, nearly half of the events can be explained (immobilisation, cancer, inherited thrombophilia), the other half of VTE cases have no known origin (called idiopathic VTE). Among the patients developing idiopathic, about 30% of them would have a recurrent thromboembolic event, 70% would not be subjected to any recurrence. This leads to difficult decisions in the population of idiopathic VTE; if the anticoagulation therapy used to treat VTE is very efficient it also has major side effects, such as bleeding events, that can be deadly. A balance must be struck between the risks of recurrent thrombosis if anticoagulant treatment is stopped versus the risks of bleeding associated with continued anticoagulation therapy that can go up to the course of decades. Physico-chemical properties of clots seem to be relevant parameters to describe their mechanical resistance and to develop risk assessment models. Currently, the most investigated methods in the literature are based on turbidimetry, rheology and permeation. Therefore, the development of optical approaches seems particularly interesting. In addition to their ease of implementation, their non-invasive and non-contact features, they would allow access to information related to the clot density, fibrin fibre arrangement, and dynamic changes during clot formation. These techniques are promising, but an integration of the different results from various methods is necessary to get a comprehensive understanding of clot properties.

Keywords: scattering,laser,biospeckle,speckle imaging,optical diagnostics for medicine
Violence and Happy Endings in the Spanish Golden Age Narrative (VIOLENDINGS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: CLOSED

The purpose of this project is to study the complex integration of violence in the Spanish Golden Age happy ending narrative. In the ‘idealistic’ Spanish narrative genres of the second half of the 16th and the first half of the 17th century, such as the pastoral and the courtly novel, the inclusion of violence is problematic. It is useful to create a gripping plot, but must be ‘solved’ to reach a happy ending. The project will propose the concept of ‘economy of violence’ to study the narrative structure of these genres and will analyze the strategies to deactivate and legitimize violence that allow these plots to resolve into a happy ending. Beyond the literary approach, the project has the ambition to propose a multidisciplinary understanding of these strategies, bringing together literature, historical sociology and gender studies. Considering the social structures of the Golden Age Spain, together with the concrete context of production and consumption of these genres (almost always written by men and widely consumed by women), the project intends to provide a critical analysis of what was presented as a happy ending and an ideal solution to violence -particularly to gender-based violence- through these plots. This panorama will be completed with a separate study of the courtly novels written by women and an analysis of how the narrative schemes produced by the male hegemonic culture and the traditional happy endings were transformed or even rejected in their narrative production. The project has two main objectives. On one hand, from a literary perspective, it aims to arrive at a better understanding of the ‘idealistic’ narrative genres of the Spanish Golden Age through the concept of ‘economy of violence’. On the other hand, from a socio-historical and a gender perspective, it aims to analyze the interplay between the dictates of the Spanish patriarchal society of the 16th-17th centuries and the structure of the idealistic narrative of this period.

Keywords: spanish golden age narrative,pastoral novel,courtly novel,happy endings,violence,violence against women
TRAMPOLINe-: A training programme to promote the industrial adoption of microbial electrochemical technologies (TRAMPOLINe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Italy,Finland,Portugal,Belgium,Germany,Netherlands,Denmark
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 2644560.0
EU funding (EUR): 2644560.0
Participants: 22
Project status: SIGNED

A training programme to promote the industrial adoption of microbial electrochemical technologies. TRAMPOLINe- is a joint academic-industrial inter-disciplinary initiative which has the primary goal of training a pool of young researchers in the field of microbial electrochemical technologies (METs) while developing innovative and ready-to-be-applied solutions for tacklingglobal environmental challenges, including contamination of the remaining freshwater sources, unsustainable production processes,anthropogenic CO2 emissions and the transition towards renewable energy environment.The main aim of TRAMPOLINe- is to form a collaborative network that (i) connects leading researchers in the core MET disciplines with SME/large companies, (ii) upgrades the state-of-the-art (SOTA) of METs into prompt industrial adoption, and (iii) trains a set of young researchers to become highly skilled MET scientists Due to the multidisciplinary nature of METs, the upgrading of MET-based cutting-edge technologies calls for international inter-sectoral cooperation in view of its proper industrial adoption. The doctoral training is carried out in research groups that are developing progressive technologies and materials for applying METs with active involvement of industrial partners that can support the market adoption of the technologies. The candidates will be developing MET-based technologies focusing especially on bioremediation, desalination, industrial bioproduction, resource recovery and on the production of CO2-based chemicals. Comprehensive technology development is supported by the work packages dedicated to microbiology of electroactive microorganisms, engineering redox reactions and reactors, innovative materials, MET-based industrial bioproduction, environmental applications and industrial adoption.

Keywords: microbial electrochemical technologies,bioelectrochemistry,
Towards a theory of endings in innovation studies (ENDINGS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1482076.0
EU funding (EUR): 1482076.0
Participants: 1
Project status: SIGNED

Because innovations are important to achieve sustainable development, substantial investments have been made in innovation research. Yet, innovations often prove insufficient for replacing established production and consumption practices. In ENDINGS, I argue that we need to overcome this innovation bias by studying how existing socio-technical systems and their respective knowledge bases end – or not. In fact, evidence suggests that it is more likely for existing systems to endure than to disappear. Still, we have a rather limited understanding of how decline and de-institutionalization unfold. This is an important research gap in several disciplines that needs to be addressed to tackle the transformations needed to achieve a more sustainable society. Combining theoretical insights from innovation and organization studies in a novel way, I will study the epistemic motors of industries by developing an analytical framework that 1) introduces a knowledge-based conceptualization of socio-technical systems; 2) differentiates between different kinds of knowledge and their prevalence in certain industries; 3) specifies the ways in which knowledge is maintained and reproduced; 4) identifies the mechanisms that lead to the erosion and extinction of knowledge; 5) substantiates endings as a precondition for innovation and systemic change. To apply this framework, I will re-formulate the method of ‘innovation biographies’ by adding the phases of erosion and extinction to the knowledge life cycle and pioneer its application in comparative cross-case analyses of three industries (energy, ICT, craft) in three geographical contexts (Germany, UK, Sweden). Based on the findings, I will formulate an original, interdisciplinary theory of endings that understands innovation as only one part of the knowledge life cycle. Such a novel perspective will open new research avenues for empirical analysis that will significantly advance research on innovation and sustainability transitions.

Keywords: innovation studies sustainability transitions institutional theory socio technical systems de institutionalization
Vascular Control of NASH Progression (CONNASHION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1741250.0
EU funding (EUR): 1741250.0
Participants: 1
Project status: SIGNED

Non-alcoholic steato-hepatitis (NASH) is a major risk factor for hepatocellular carcinoma (HCC), the 6th most common cause of cancer-related death worldwide. The transition among different NASH stages to HCC stems from the complex interaction of multiple factors, including gut-liver axis modifications and a progressive dis-architecture of the liver parenchyma. The central role of endothelial cells in regulating the metabolic crosstalk along the gut-liver axis and in shaping the spatial organization of the liver parenchyma suggests a potential vascular control of NASH progression. However, the possibility to precisely define the endothelial contribution is restrained by the limited ability to correlate gene expression profiling and functional readout, such as protein phosphorylation, with the complex morphological modifications occurring during NASH. To overcome these limitations, we combined innovative “spatial sorting” strategies with transcriptomics and quantitative phosphoproteomics, providing the first draft of the anatomical organization of proteins signaling in the liver vasculature. Moreover, we unambiguously identified tyrosine phosphorylation – the main target of the anti-angiogenic therapy (ATT) – as one of the most spatially regulated signaling event. Building on this expertise, we will combine spatial sorting strategies in gut and liver with mouse models of NASH progression and advanced imaging modalities to pursue the following aims: 1. Provide a spatiotemporal characterization of the gut and liver vasculature undergoing NASH development. 2. Dissect the vascular determinants of NASH progression. 3. Identify the molecular mechanisms underlying the synergistic effect between AAT and immune checkpoint inhibition. Together, our results will lay the foundation for understanding the molecular basis of a synergistic AAT and immune therapy in HCC, and help to identify novel prognostic markers as well as potential therapeutic targets.

Keywords: vascular biology,liver zonation,nash,hcc,anti angiogenic therapy,immune therapy
Mucociliary adaptations and gut microbiome establishment in Xenopus (MAGIX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1995921.0
EU funding (EUR): 1995921.0
Participants: 1
Project status: SIGNED

Cell type compositions determine tissue morphologies and functions, are adapted during evolution, and their changes cause diseases. However, we do not understand how cell type compositions can be controlled and modified to predictively achieve different organ functions. The goal of the MAGIX project is to understand the developmental mechanisms controlling cell type compositions, and to mechanistically link variations of cell type compositions to physiological properties of tissues in development and disease. We will use mucociliary epithelia as they provide an optimal system to study how adaptations of cell type compositions are regulated and how they determine organ functions. They build on a conserved gene-regulatory network to generate epithelia with different functions across species and organs derived from all three germ layers. We hypothesize that key epigenetic, patterning and remodeling mechanisms are used in a modified fashion to generate different functions and morphologies in different organs. In this project, we will establish two new vertebrate mucociliary model systems in the Xenopus foregut and the mouse esophagus, multi-modal resources, and integratively analyze data across models. We will then test a series of hypotheses experimentally to gain insights into the mechanisms regulating mucociliary cell type compositions, their adaptations, and to model mucociliary patterning in silico. Lastly, the developmental functions of foregut mucociliary epithelia in Xenopus and mice will be investigated to reveal potential contributions to gut microbiome establishment, thereby uncovering a new role for mucociliary epithelia in vertebrate development. Using a range of state-of-the-art techniques, the MAGIX project will study mucociliary adaptations to resolve fundamental questions in cell and developmental biology, and to provide translational insights into human diseases that kill >8 Mio. people per year (chronic airway diseases, cancers, motile ciliopathies).

Keywords: xenopus,mucociliary epithelia,endoderm,microbiome