Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of novel biomimetic engineered dental implants for periodontal ligament regeneration (BEDIMPLANTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

BEDimplants project represents an innovative concept in oral implantology based on a multidisciplinary approach in periodontal regenerative medicine and tissue engineering that has the potential to significantly influence the outcome of medical and dental therapies. The project aims to develop novel biomimetic engineered dental implants (BEDimplants) that self-promote the regeneration of periodontal ligament (PDL) and provide in a single implant therapy the adequate environment to promote specific cell lineages, such as primary human gingival fibroblast (hGF) and dental pulp stem cells (hDPSC), to integrate, differentiate and proliferate within an artificial biomimetic extracellular matrix (aECM). The utilization of natural products and biomolecules present in the native periodontal ECM such as collagen, hyaluronic acid and cell signaling molecules, BMPs and TGFbs, to be grafted onto titanium surfaces is presented as a promising approach to the development of novelty implantable devices that mimic the complexity of ECM which can be reabsorbed or degraded by the organism after their implantation. Furthermore, self-crosslinkable bioactive peptide sequences (RGD and DGEA) can be synthesized and chemically linked to those biomolecules tailoring their biofunctionality and providing a biomimetic three-dimensional aECM-g-Ti scaffold that can be implanted in the presence of the appropriate cell cocktail that fulfill all the requirements of PDL tissue engineering.

Keywords: periodontal ligament,tissue engineering,dentistry,regenerative medicine,dental implants,hyaluronic acid,titanium
Molecular mechanisms and cellular consequences of enterovirus persistence in cardiomyocytes. (CARDIOVIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-03-01
End date: 2017-06-01
Duration (months): 30.0
Total project cost (EUR): 156863.4
EU funding (EUR): 156863.4
Participants: 2
Project status: CLOSED

Enteroviruses (EV) are small naked single-stranded positive RNA viruses of approximately 7,400 nucleotides. Their genome is flanked on the 5' end by a non-coding region (NCR), which is crucial for the initiation of the replication and translation of the viral genome. Enteroviruses are common human pathogens, transmitted through fecal-oral and respiratory routes. Although the majority of EV infections remain asymptomatic, these viruses, especially group B coxsackieviruses (CVB), are considered to be a common cause of acute myocarditis in children and young adults, a disease which is a precursor to 10-20% of chronic myocarditis cases as well as dilated cardiomyopathy (DCM, prevalence = 7 cases / 100,000, second leading cause of heart transplantation worldwide after ischemic heart disease). However, the viral molecular mechanisms involved in the progression of acute myocarditis to chronic myocarditis and subsequently to DCM are currently poorly understood, thereby limiting the development of new specific therapeutic strategies. In 2011, our research team (EA-4684 CardioVir/FRS CAP-santé, University of Reims Champagne-Ardenne) reported CVB strains presenting with genomic 5’ terminal deletions ranging in size from 15 to 35 nucleotides in explanted heart tissue collected from patients suffering from idiopathic DCM. These deletions could explain how the virus can persist in the heart long after the acute infection leading to the development of chronic cardiomyopathies. The objectives of this proposal are to determine the mechanisms by which deleted EV ensure the translation and replication of their genomes and to assess the effects of persistent infection on the structures and functions of infected cardiac myocytes. A better understanding of the molecular mechanisms implicated in viral persistence will stimulate the research into new therapeutic strategies to prevent and treat chronic infections caused by EV.

Keywords: enterovirus,genomic deletions,replication,translation,viral persistence,cardiomyocyte,dilated cardiomyopathy
TEMPERATURE DRIVES EVOLUTION: IN SEARCH OF GENE EXPRESSION DIFFERENCES BETWEEN EURYTHERM AND POLAR STENOTHERM FISHES (POLAREXPRESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 216952.8
EU funding (EUR): 216952.8
Participants: 1
Project status: CLOSED

It is generally agreed that much of variation in gene expression in response to a particular environmental condition has a heritable genetic basis and ultimately, combined with extensive expression variability, it provides the substrate for evolution. Notothenioids, perciform fish living in Antarctic waters, are highly stenotherm organisms and offer a truly unique opportunity to study what characteristics of gene expression levels and pool of expressed genes (the pool of messenger RNAs, mRNA, is called the transcriptome) are behind the differences between stenothems and eurytherms, as a result of the evolution of temperature preference. Studying these fish could help to directly identify the transcriptomic basis of temperature-related evolutionary adaptation by comparing species living in thermally distinct habitats to their most phylogenetically basal relative. In this proposal, three target notothenioid species will be taken into account: two extreme stenotherms adapted to polar conditions, Notothenia rossii and Champsocephalus gunnari and the subpolar eurytherm Eleginops maclovinus. This proposal is aimed at verifying if the evolutionary adaptation to a specific temperature, causes any difference in expression levels at a common set of genes. The modern methodology adopted, the transcriptome sequencing (Illumina RNA-Seq) and the quantitative RT-PCR (OpenArray system) are aimed at collecting and validating a dataset of gene expression rates as broad as possible. Expression of genes hypothetically involved in the temperature adaptation will be also studied in different body tissues, after short and long term exposure to a temperature higher than natural. The likely reduction in available habitats due to global warming and their high specialization to low temperature makes notothenioids hypothetically more vulnerable and potentially genetically compromised in their abilities to acclimate to rising water temperatures and for this reason a hot target for conservation.

Keywords: antarctic fish,gene expression,transcriptome,eurytherm,stenotherm,climate change
GOAl - Groups and operator algebras (GOAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 203609.7
EU funding (EUR): 203609.7
Participants: 1
Project status: CLOSED

The goal of this research project is to clarify the relation between locally compact groups and their associated von Neumann and C*-algebras. I have three objectives. First, I want to understand general criteria for a locally compact group G implying that its group von Neumann algebra L(G) is a non-amenable factor. Ideally, I will find a characterisation of such groups. Second, I want to find C*-superrigid groups, that is discrete groups G such that any other discret group whose reduced C*-algebra is isomorphic with the one of G, is already isomorphic wiht G. Third, I want to investigate the fine structure of the group von Neumann algebras of discrete hyperbolic groups. Based on Popa's deformation/rigidity theory, my aim is to generalise a theorem of Voiculescu on the possible spectral type of MASAs in free group factors to MASAs in group von Neumann algberas of hyperbolic groups. This project is going to be excecuted in Kyoto University and the University of Münster, two of the most renowned places in operator algebras and geometric group theory.

Keywords: group von neumann algebras,group c*-algebras,ii_1 factors,deformation/rigidity theory,w*-superrigidity,abscence of cartan subalgebras,group von neumann algberas of locally compact groups
Development of biodegradable conducting scaffolds for treating peripheral nerve lesions taking into account the influence of mechanical vibrations on neurons regeneration in tissue engineering (NERVE-REPAIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-02-27
End date: 2018-06-27
Duration (months): 36.0
Total project cost (EUR): 282542.4
EU funding (EUR): 282542.4
Participants: 1
Project status: CLOSED

The proposed project aims to develop engineered biodegradable conducting 3D scaffolds capable of promoting neuronal survival, as well as axon extension and guidance, for treating peripheral nerve lesions. Current approaches focus on the sensitivity of neurons to the surrounding environment, which includes surface topography, biochemical cues, and electrical activity. Constructs implanted in vivo are also subject to mechanical constrains that have an impact on tissue formation. This project aims to investigate the influence of these mechanical stimulations on scaffolds and neuronal cells proliferation. Moreover, the mechanical constrains applied on engineered tissues inside the body will be evaluated with flexible biodegradable strain sensors developed for this purpose. Finally, scaffolds with various geometries designed to absorb the vibrations will be fabricated and evaluated. This project proposes an additional strategy that can be combined to other therapies to improve nerve regeneration. The first part of the project will be performed at Stanford University, USA, in the group of Organic and Carbon Nano Materials for Electronic Devices led by Prof. Z. Bao. Main tasks: literature search, produce the scaffolds, implement a measurement setup allowing mechanical stimulations of scaffolds in liquid, perform an in vitro degradation study on scaffolds, develop mechanical models, develop and characterize a biodegradable strain sensor. The second part of the project will be performed at EPFL, Switzerland, in the Laboratory for Soft Bioelectronic Interfaces led by Prof. S. Lacour. main tasks: Implement a mechanical stimulation setup in liquid based on existing setup in the lab, produce scaffolds, perform an in vitro study on scaffolds with neuronal cells and mechanical stimulation, perform an in vitro study on the strain sensor to verify its biocompatibility, design, fabricate, and assess the in vivo performances of scaffolds with new geometries.

Keywords: implantable devices biomedical engineering tissue engineering nerve regeneration biodegradable conducting polymer nerve scaffold biodegradable strain sensor flexible sensor mechanical vibration neuron
Anatomy and dynamics of the human replisome (ANDYHREP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 2
Project status: CLOSED

Accurately copying its whole genome is perhaps the most important task of the cell. Mistakes in DNA replication can result in cell death or, potentially worse, in mutagenesis and genomic instability, which in turn can lead to uncontrolled proliferation, the basis of cancer. Elucidating the factors involved in DNA replication and understanding the mechanisms by which human cells guarantee the precise duplication of billions of base pairs and thereby appropriate proliferation are of utmost importance when aiming at defeating several diseases, among which cancer stands out as one of the leading causes of death in the world. While the actual enzymatic activity of DNA synthesis is accomplished by DNA polymerases, a remarkable set of extra factors is required for replication within the cell. Though the core replication components seem to be conserved from yeast to humans, in mammals the putative homologues of several key factors likely act with different mechanisms or have additional functions, as suggested by the low homology level and presence of extra domains. Thus, the object of my proposal is to identify novel factors involved in normal DNA replication progression and the response to replicative stress at the replisome level, specifically in human cells. I will put additional emphasis on elucidating the function of known metazoan-specific factors, which likely play a key role in the complex regulatory mechanisms required in higher organisms. To this end, I will combine various cutting edge methods, like nanobody-based sequential purifications, SILAC mass spectrometry and 3D-SIM microscopy, to develop assays to isolate active replisomes from human cells and study the identified factors mechanistically. This strategy will allow me to exploit and significantly expand my technical expertise and, complemented by the selected world-class host scientist and institute, to grow into an independent scientist and enhance Europe’s research excellence.

Keywords: human replisome mechanisms of dna replication silac mass spectrometry proteomics replicative stress
Asymmetric organocatalysts for remote functionalization strategies (REMOTECAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 221154.6
EU funding (EUR): 221154.6
Participants: 1
Project status: CLOSED

Research in the area of aminocatalysis moves at breathtaking speed: many catalytic reactions now considered to be “standard issue” by organic chemists were almost unthinkable just 10 years ago. The development of new catalysts often makes it possible to generate previously unattainable compounds, which could have unique physical, chemical or biological properties. But the basic science is as important as the applications: studies of catalytic mechanisms often uncover new modes of chemical reactivity, such as the way polienamines work, forcing us to think different about the way molecules interact and react. The REMOTEcat project is an innovative proposal in the area of asymmetric organocatalysis tutorized by Prof. Jørgensen at the Centre for Cataysis (Aarhus, Denmark). It is scientifically based on a novel mode of activation (tetraenamine catalysis) for the development of new methodologies providing relevant chiral frameworks. The project is aimed at designing organocatalysts for the construction of new stereogenic centres located at even more remote positions from the stereodifferentiating element of the aminocatalyst described up to date. These catalysts will open access to a variety of enantioenriched compounds and will be used in the total synthesis of natural products or bioactive molecules. The successful execution of the REMOTEcat project will allow the applicant to acquire and/or improve his research competences thus strengthening his professional maturity. This is particularly relevant when considering the highly competitive discipline of organocatalysis. New methods are developing rapidly for the synthesis of chiral molecules. As a consequence, acquiring broad research skills is even more crucial to keep up a high quality research level. Therefore, a Marie Curie fellowship held in Prof. Jørgensen`s top international research group in organocatalysis, would be an important step in the direction of establishing his career as an independent researcher in EU.

Keywords: organic chemistry,homogeneous catalysis,asymmetric catalysis,organocatalysis,remote functionalization,aminocatalysis,tetraenamine,organic synthesis
Power quality in coastal smart grids (SMARTWAVE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-05
End date: 2017-01-04
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

Although almost half of the European population lives in coastal areas, the specific issues associated with the dramatic transformation of the coastal electrical networks into smart grids have been little addressed. These issues stem from the fact that coastal electrical networks are usually more structurally fragile than inland electrical networks. Hence, the former are more prone to be affected by a significant deterioration of the quality of the electricity supplied to the customers which is referred to as “power quality”. This problem will be further aggravated due to the high amount of distributed renewable energy sources (e.g. wave energy farms and groups of photovoltaic panels), whose rapid power fluctuations may be very detrimental to power quality, and of electric vehicles to be connected to the low-voltage, electrical distribution systems in the next decades. However, no study has addressed their combined grid impact yet in the specific context of coastal electrical networks. This constitutes a considerable gap which must be filled immediately for Europe to meet its targets in terms of renewable energy consumption. The proposed “SmartWave” research project will constitute a positive step in this direction. Its objective is to bring the research on coastal smart grids to the next level by tackling urging challenges by means of a realistic, integrated approach which addresses the combined impact on power quality of the different renewable energy sources mentioned earlier and of electric vehicles. It will also investigate different options to mitigate this impact in the form of intelligent charging scenarios for electric vehicles. The studies will be conducted based on typical coastal networks which will allow the conclusions of the research project to be transferable to a wide range of maritime countries, thus giving it a worldwide impact. Keywords: power quality, renewable energy sources (wave and photovoltaic), coastal smart grids, electric vehicles

Keywords: power quality,renewable energy sources (wave energy farm and photovoltaic panels),coastal smart grids,electric vehicles,ancillary services,intelligent charging scenarios for electric vehicles
Design and Expansion Turbine for Domestic Refrigerators and Freezers (DETFORDRF 2.0)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

This proposal for a Marie Curie Intra-European Fellowship for Career Development is meant for the training of a research fellow from Spain in the laboratories of BSH Bosch und Siemens Hausgeräte GmbH, (BSH), Germany, the largest home appliance manufacturer in Europe. The goal of the DETforDRF 2.0 project is to explore the required expansion mechanism in a cooling circuit of a household refrigerator in order to increase the efficiency of the system and the utilization of the released energy in the expansion process. The proposed research-training activities will be done in an industrial context and will cover the science, technology and business value chain. The training will start by applying relevant fundamental principles of the physics of fluid dynamics, followed by the design and construction of a turbine, based on an innovative concept to decrease the energy consumption of refrigerators and freezers, and ends with a market study to explore the possibility of mass production of the newly developed concept. The innovative concept relies on the expansion mechanism that is realized through the capillary tubes and permits the transformation of the energy of the system that will be lost otherwise, to a useful energy that will be used to increase the heat transfer coefficient in the cooling circuit. The project is focused on refrigerators, but the concept could be generalized to other applications, such as air-conditioners, and would generate insights on the recuperation of wasted energy for applications in other domains.

Keywords: domestic refrigerator,household appliance,fluid expansion and dynamics,thermodynamics,hydrodynamic cavitation,capillary tubes,energy efficiency,cooling circuit efficiency,evaporator,condenser