Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Characterization of the gene and protein networks regulated by Staufen 2 in neurogenesis and their alterations in AD (NEUROSTAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-10-12
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Neurogenesis is a crucial process by which new neurons are formed in the brain through the conversion of Neuronal stem cells (NPCs). Altered neurogenesis has been identified in Alzheimer’s disease (AD), in both human brains and rodent models, yet the exact mechanism of the dysregulation is unknown. Over the past few years, growing evidence indicates that RNA-binding proteins (RBPs) play a critical role to fine-tune neurogenesis and mediate cortical development in the mammalian brain. Among these, the RNA-binding protein Staufen 2 (Stau2) plays an important role during neurogenesis unbalancing NSCs maintenance and differentiation, which is critical for brain development and functions. Importantly, STAU2 protein has been shown to be downregulated in AD, suggesting a possible role of STAU2 in impaired adult neurogenesis in AD In this project, I will use induced pluripotent stem cells in combination with single-cell transcriptomic methods to characterize the unknown gene and protein networks regulated by STAU2 in neurogenesis at the single-cell level and investigate their relationship to altered neurogenesis in AD. This work will provide a solid molecular knowledge about the role of Stau2 in neural differentiation and its impact in neurogenesis in AD. Furthermore, I will develop a pipeline for the study of RBPs in human diseases and I will acquire indispensable scientific skills to become an independent research in Europe Together, this study will provide a solid molecular knowledge of the role of RBPs in neural differentiation, enabling the development of new personalized medicine therapies, which is in compliance with the Horizon H2020 Health demographic change and wellbeing program.

Keywords: rna binding proteins,post transcriptional regulation of the gene expression,single cell sequencing,alzheimer s disease,stem cell,mrna decay,mrna localization
Technical and Social Innovations in the Caucasus: between the Eurasian Steppe and the Earliest Cities in the 4th and 3rd millennia BC (ARCHCAUCASUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-07-01
End date: 2025-06-30
Duration (months): 72.0
Total project cost (EUR): 2487875.0
EU funding (EUR): 2487875.0
Participants: 1
Project status: SIGNED

This project leads to one of the most dynamic regions in prehistory: the Caucasus of the 4th and early 3rd mill. BC. During this vibrant time, basic innovations emerged, which were crucial until the 19th century: wheel and wagon, copper alloys, the potter’s wheel, new breeds of woolly sheep, domestication of the horse, and others. At the same time, massive migrations from the East European steppe during the early 3rd mill. BC changed the European gene pool. The project challenges the still predominant narrative that all technical achievements stemmed from urban centres in Mesopotamia. New studies have created space for alternative hypotheses: possibly it was not the development of new techniques, but instead their adaptation from different ‘peripheries’ and their re-combination and re-configuration that formed the basis for the success of these ‘civilisations’. The Caucasus, linking Mesopotamia to the Eurasia and Europe, is for the first time in the focus of a study on innovation transfer. The study will make a major contribution by investigation of four axial innovations: wheel and wagon, metal alloys, silver metallurgy and woolly sheep. 40 wheels will be analysed by computer tomography and strontium isotopes. Some 300 copper alloys artefacts and 200 silver objects will be examined using mass spectrometry with laser ablation. 400 aDNA genom-wide analyses of humans from burials in the North Caucasus will offer the unique chance of elucidating the role of migrations for the spread of innovations. The pottery in the region, often linked to Mesopotamia, will be studied under technical aspects and is a complementary path to shed light on migration and the transfer of knowledge. Excavations in settlements will allow building up a chronology using 400 AMS 14C analyses. The project is multidisciplinary, making use of the most up-to-date analytical methods. Our long experience and reputation on both sides of the Caucasus is the ideal background for cutting-edge research.

Keywords: innovation,technologies,caucasus,bronze age,paleogenetics,material studies,transfer of knowledge
New states of Entangled Matter Out of equilibrium (NEMO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 1521423.0
EU funding (EUR): 1521423.0
Participants: 1
Project status: SIGNED

When an extended quantum system is suddenly brought out of thermodynamic equilibrium all excitations collectively participate in the ensuing quench dynamics, causing a plethora of unconventional and exotic effects, in particular in low spatial dimensions where the effects of interactions and integrability are enhanced. The theoretical study of the non-equilibrium dynamics is hampered by the fact that the time dependent many-body wave function is highly entangled on spatial scales which rapidly grow in time. Consequently, a satisfactory description of the quench dynamics is a timely challenge whose solution cannot prescind from a precise characterisation of the entanglement content of the systems of interest. The ambitious goal of this proposal is to find and characterise new non-equilibrium states of matter guided by their entanglement content. Two parallel lines of research will help achieving this goal. One line concerns the study of some entanglement indicators like entanglement Hamiltonian, spectrum, negativity and relative entropies which, contrary to the entanglement entropy, are not yet widely used as tools for investigating many-body systems. The other line focuses on the study of some frontiers of non-equilibrium one-dimensional physics which include quantum quenches in spinful fermionic systems, the determination of the exact time dependence of correlation functions after a quench, and the use of integrable hydrodynamics for investigating transport in one-dimensional systems. Particular attention will be devoted to the experimental realisation of the proposed non-equilibrium protocols. The main tools to achieve these goals will be conformal field theories and integrability complemented by numerical simulations when the former two are not applicable.

Keywords: entanglement,non equilibrium dynamics of isolated quantum systems,integrability,conformal field theory
Safety Gloves for Protection of Health Care Professionals (SafeGlov)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-12-01
End date: 2023-05-31
Duration (months): 42.0
Total project cost (EUR): 2655800.0
EU funding (EUR): 1850060.0
Participants: 1
Project status: SIGNED

Despite high-tech medical equipment the recurrent incidence of fatal needlestick injuries and persistent thread of subsequent infections of medical staff in many clinical applications is a big challenge in today’s modern society. Many surgeons and nurses try to protect themselves from infection risks by wearing two gloves on top of each other. In addition to the high consumption of material precarious working conditions with a permanent thread of serious diseases (HIV, hepatitis C) are drastic consequences for humans constantly exposed to potentially infectious liquids. Also the economic consequences are huge, as follow-up costs amount up to USD 1,691 per needlestick injury (and additional treatment, litigation, compensation costs) for hospitals and society. The project goal of replacing double gloving in surgical fields is fully in line with EU directive 2010/32/EU implemented to prevent workers' injuries caused by all medical sharps (including needlesticks). Within the SME II project, Smarterials Technology GmbH (ST) introduces a ground-breaking double gloving substitute innovation based on micro-particles, multi-layers and the use of natural raw materials (TRL 6-7) to the European (and global) market. The USPs of high protection, superior tactility and dexterity, less energy and material consumption at low cost will change the rules of the surgical gloves market. During the project production processes at manufacturers need to be adapted, the technology to be demonstrated in core applications (in particular surgery) and detected customers needs to be met in order to prepare the market entry and make this technology the new protection standard in healthcare. This ever-increasing sector is a high-volume market worth more than € 1,4 billion. The SME II project is a major part of ST´s strategy and will lead to significant increase in turnover far beyond € 100 million and to a more environmentally friendly, protected and healthier society in Europe.

Keywords: needlestick injuries,polymer particle composites,advanced materials,double gloving,manufacturing and processing,surgery,protection,infection prevention,surgical site infections
The first high-precision Computer-Controlled Collarbone Cutter for Whitefish (4CWhite)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our company, CURIO ltd., founded in 2007, is one of the Icelandic leading developers and manufacturers of fish processing machinery. With a team of 40 people, we design, produce, and commercialize three types of high performance fish processing machines (i.e. heading, filleting, and skinning), and a reference of knife sharpening. Currently, we sale our machinery to over 100 of the main fish processing companies worldwide. This close contact with the fish processing industry enabled us to identify a new market niche to be exploited: Inefficient practices and lack of specialized machinery during fish processing (more specifically during collarbone cutting), which translate in the underutilization or even wastage of tons of fish meat every day. In this sense, and given our commitment with fish processing optimization, we developed 4CWhite: the first computer controlled fish processing machine designed to cut the collarbone of different de-headed whitefish species. In this way, 4CWhite will increase the loin yield up to 2% to be profitable in further processing, in comparison with current alternatives (i.e. mainly manually cutting or by in-house adapted heading machines) that represent a loin wastage up to 8%. 4CWhite’s productivity (20,000 fish/day), extended service life (>15 years), reduced labour requirements (only one operator) demonstrate that it is the best value for money solution to increase the efficiency of this step of fish processing and promote a more sustainable use of oceans resources. Based on 4CWhite sales on demand among the major whitefish processors from Nordic and North-western European countries, we expect to sell at least 200 4CWhite units by 2022, reaching a market share around 8%. Our financial figures forecast €58 million of cumulative revenues for the period 2020 - 2022 with a total gain profit of about €11.6 million and a labour force increase of 50% (20 new operators).

Keywords: loin yield,sustainability,efficient use of resources
Portable SolUtioN for dIstributed geNeration in a BOX (Suninbox)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain,Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Our project arises from a joint business venture between Solarbox Solar Solutions (Solarbox) and Generaciones Fotovoltaicas de la Mancha (GFM) to develop a portable solution (Suninbox®) for the off-grid generation market. The joint venture started in 2007 for the design of a solar tracker (Patent ES 2322527B2) to increase the collection efficiency of solar systems by more than 30% whilst making it easy to transport to cover the lack of solutions in the market with good price/characteristics rate. Suninbox® consists of a portable Solar PV energy solution that integrates in a certified container all the components necessary to generate electricity autonomously. This will allow both Solarbox and GFM to gradually reach industrial scale with increasingly lower costs (objective price of 4.25 €/W per 12kWp module), increasing penetration in the international market. Our end users belong to specific markets where there is a need of affordable and portable off-grid energy sources (not connected to the main or national electrical grid): -RURAL AREAS: they represent 90% of all territory in the EU 27 and 56% of the population. They generate 43% of all economic value and support 55% of all employment. In these areas, there are 12,000 farms of which 69% are small remote farms of less than 5 Ha of agricultural land. -TRANSCEIVER STATIONS FOR MOBILE COMMUNICATIONS NETWORKS: the off-grid energy source demand in this sector is steadily increasing with a forecast revenue growing from $1.6 billion in 2012 to more than $10.5 billion in 2020. There are approximately 5 million radio base station sites in the global telecommunication network, 900,000 located in areas where central electricity grid connections are unavailable. -RURAL ELECTRIFICATION IN DEVELOPING COUNTRIES: universal access by 2030 will require 399 TWh for mini-grids and 171 for off-grid. The global market potential is expected to be in the order of more than 250,000 million €.

Keywords: distributed generation,off grid energy,solar tracking,photovoltaics
European Network of Research and Innovation Centres and Hubs in Latin America and the Caribbean (ENRICH in LAC)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Hungary,Brazil,Portugal
Call: Centres/Networks of European research and innovation: follow-up of the CEBRABIC action (H2020-IBA-SC6-CEBRABIC-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1003812.5
EU funding (EUR): 1003812.5
Participants: 6
Project status: SIGNED

To support Europe’s role as the scientific and technological base and to foster its competitiveness including its industries, as well as to contribute to tackling global challenges, the ENRICH Centre (founded as Non-Profit Association in Brazil) facilitates collaboration between European and Brazilian Science, Technology and Innovation (STI) actors. The CEBRABIC project started as an innovation network focussing on EU-Brazil cooperation. The overall objective of the follow-up of the CEBRABIC action is to capitalise on the work done and extend the operations of the ENRICH (European Network of Research and Innovation Centres and Hubs) Centre in Brazil to include also other countries in the region. With an extension to Argentina, Chile, Colombia and Uruguay in the initial phase, the strategy developed will include the view to expanding the coverage in the medium-term. The four countries have been chosen due to their membership status within the South American trade block MERCOSUR and due to their position on the Global Innovation Index 2019. ENRICH in LAC aims to expand the community in EU and LAC through member-and partnerships, representation and other means of involvement to the Centre and its activities. Activities in Europe will focus on increasing the visibility of the Centre and its services, establishing new partnerships with STI actors, and facilitate technology transfer. The ENRICH in LAC service portfolio will be adopted and extended based on the needs and interests of the European researchers and innovators. Focus will be given to building competences on selected thematic fields such as bioeconomy, digitalisation, renewable energy, sustainable urbanisation as well as on horizontal topics such as capacity building on international cooperation and research and innovation management. The project will have a duration of 36 months. The self-sustainability objective is foreseen to be reached until the end of the funding phase.

Keywords: europe lac cooperation,european sti landscape,enrich,european innovation network,cebrabic
Next-Generation Integrated Energy Services fOr Citizen Energy CommuNities (NEON)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Italy,Italy,Italy,Spain,Spain,Italy,Cyprus,Switzerland,Serbia,France,France
Call: Enabling next-generation of smart energy services valorising energy efficiency and flexibility at demand-side (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-09-01
End date: 2024-02-29
Duration (months): 30.0
Total project cost (EUR): 1999812.5
EU funding (EUR): 1999812.5
Participants: 15
Project status: SIGNED

While building on results of recently (or soon to be) concluded EU projects, NEON will undertake coordination and support activities to advance the leveraging technologies and concepts in order to deliver the next-generation integrated energy services for communities, targeted to enhance the life quality of European citizens, while improving the performance of energy system. In this endeavour, NEON will exploit building energy efficiency, renewable energy generation and storage, and demand flexibility to increase energy savings, reduce CO2 emissions, and provide cost savings across sectors. NEON will engage grid stakeholders, service providers and final consumers to establish, in co-creation, the cross-sectoral arrangements and underlying service concepts. NEON will join multi-measure energy efficiency interventions and advanced control capabilities to maximize the positive impact of energy efficiency by improving the building operation performance and make the demand-side flexibility as manageable and procurable resource. NEON will advance the energy efficiency services already available on the market and couple them with other energy services and non-energy benefits, providing an integrated approach to energy generation, storage and consumption management. To enable servitization of proposed concepts, NEON will bring innovative business and contracting models by integrating EPC with P4P schemes, and establish innovative M&V methodology. The concept of Citizen Energy Communities (CECs), as introduced by Directive (EU) 2019/944, will be leveraged to set the legal and business foundations to enable faster market uptake, and facilitate communities, both residential and non-residential, in becoming energy-efficient. The proposed service concepts and business models will be showcased in 4 CEC setups (residential, non-residential and mixed) serving as early adopters, whereby follow-up replication plans across 7 “follower” communities will be developed during the project.

Keywords: citizen energy communities,smartgrids,optimal energy asset scheduling,demand response,smart contracts
Two Dimensional Materials for Bolometers of the Future (FUTBOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Remote thermal sensing and imaging is currently one of the most prominent technological fields. Its market value is expected to grow beyond $10 billion/year by 2020. The simplicity and low price of uncooled radiation heat sensors, bolometers, have made them subjected for extensive research. The route for improved performance is enhanced absorption of thermal radiation, improved thermal isolation, reduced thermal mass, increased sensitivity of thermal transduction and reduced noise. Atomically thin crystalline materials, 2D materials, are an attractive alternative to traditional bolometer materials. Their extreme aspect ratio allows for excellent thermal isolation, low thermal mass, and electrostatically tunable electrical and optical properties allows for temperature sensing and strong light-matter interaction. FUTBOL aims to take the advantage of 2D materials, as new bolometer material, to create a novel sensor with unseen resolution and bandwidth. A strip of 2D material is suspended to thermally isolate it from its surroundings and form a Fabry-Pérot cavity. Thermal radiation is partly absorbed and partly transmitted into the cavity where it resonates. As the 2D material is not a perfect mirror it will eventually absorb a large fraction of the radiation. The conductivity of the 2D material is electrostatically tuned, using the gate voltage, to maximize absorption. It is utilized that an ultrathin metallic layer reaches 100% absorption when its resistance equals the product of the layer thickness times the vacuum impedance. Absorption of radiation leads to heating of the thermally self-sensing 2D material which is transduced either via changes in its electrical resistance or mechanical resonance frequency. Advantages of the bolometer design are minimal thermal mass, excellent thermal isolation, short time constant and the ability to electrostatically tune the absorption of radiation, combined leading to unseen resolution and bandwidth.

Keywords: bolometer,nems,2d materials,mos2,nanoscale