Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Circular DNA in screening and prognosis of pancreatic cancer (CIRCULAR VISION 2.0)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-06-01
End date: 2027-11-30
Duration (months): 30.0
Total project cost (EUR): 2499824.0
EU funding (EUR): 2499824.0
Participants: 2
Project status: SIGNED

Despite significant advancements in cancer therapy, the inadequate diagnosis and prognosis of many common cancers continue to limit the full potential of life-saving treatments. This gap is particularly evident in the case of pancreatic ductal adenocarcinoma (PDAC), where late-stage diagnosis, coupled with limited treatment options, results in a mere 12% five-year survival rate for patients. To improve survival rates, innovative technologies that facilitate early detection are urgently needed. In response to this unmet need, our preceding research has identified a novel tumor biomarker – circular DNA from chromosomes. Under the FET project CIRCULAR VISION, we have successfully developed a technology tailored for early-stage detection and prognosis of PDAC based on circular DNA profiles from plasma and tumors. The current project seeks to advance this technology towards commercialization. Our strategic roadmap includes maturation and validation of the Circle-DNA technology to TRL5 by advancing our molecular methods for purification of circular DNA from tumor and plasma, optimizing our computational method for mapping of sequenced circular DNA, and building a machine-learning classifier for detection of cancer from maps of circular plasma DNA. We will validate the Circle-DNA technology for screening on plasma and for the prognostic solution on tumors from ~1000 individuals. To commercialize our transformative technology, we will develop a robust and comprehensive business plan for our spin-out company, CARE-DNA, initiate fund-raising activities to secure future financing, map the regulatory approval pathway under the In Vitro Diagnostic Regulation, and prepare the launch of early commercial activities targeting hospitals in Denmark. By aligning cutting-edge scientific innovation with a clear commercial trajectory, this project is poised to make a profound impact on PDAC diagnosis and prognosis, which can ultimately transform patient outcomes across an array of cancers.

Keywords: machine learning classifier,cancer,pancreas,biomarker,screening,early detection,circular dna,eccdna,ecdna,ctdna,cfdna,ivd,graphical user interface
GREENHOUSE GAS FLUXES AND EARTH SYSTEM FEEDBACKS (GreenFeedBack)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Denmark,Sweden,Finland,Belgium,France,Norway,Germany,Greenland,Canada,United Kingdom,Estonia
Call: Improved understanding of greenhouse gas fluxes and radiative forcers, including carbon dioxide removal technologies (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 8151049.5
EU funding (EUR): 8151049.5
Participants: 16
Project status: SIGNED

The Ambition of GreenFeedBack is to enhance knowledge of the GHG dynamics in the ecosystems and link GHG in terrestrial, freshwater and marine ecosystems to provide a solid basis for estimation of regional and global climate feedback processes taking human pressure on ecosystems into account. GreenFeedBack will study the processes in sensitive terrestrial, freshwater, coastal and marine areas of which some are hypothesized to be tipping elements in the climate system. Thus, we will primarily focus on high latitude terrestrial and freshwater systems, marine shelves and ocean areas and thereby advance the process-based representation of ecosystems in Earth System Models (ESM). The analysis will involve co-design between scientists and stakeholders. We will use data from the ICOS and ACTRIS stations in Europe and the GIOS, GEM and SMEAR network in Greenland and Finland as well as data from dedicated field and laboratory studies. The enhanced knowledge will be used to improve descriptions of the GHG processes for implementation in ecosystem models and ESMs. Hence, GreenFeedBack will improve and apply ecosystem- and Earth System models to advance our understanding of GHGs effect on climate variability over different time horizons.

Keywords: carbon cycle,air sea exchange
Protease Profiling and Triggered Drug Delivery for Personalized Cancer Therapy (PROTECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1842642.0
EU funding (EUR): 1842642.0
Participants: 1
Project status: SIGNED

Proteases are involved in all hallmarks of cancer and are key regulators of tumor progression. The difficulties to monitor protease activity in vivo with sufficient sensitivity and selectivity make development of protease targeting cancer drugs and implementation of protease activity as a diagnostic and prognostic biomarker very challenging. The aim of PROTECT is to develop a novel comprehensive protease activity profiling platform for cancer-associated extracellular proteases that can address the main limitations of current strategies for in vivo protease activity monitoring with the ambition to enable a dramatic increase in sensitivity and multiplexing capabilities. We will design Liposomal Activity-Based Sensors (LABS) that can amplify proteolytic cleavage by triggering release of liposome encapsulated synthetic biomarkers. We will further leverage the possibilities to extract tumor specific protease profiles for development of personalized protease-triggered liposomal drug delivery vehicles (PROVES) for precision medicine. Sophisticated protease-responsive membrane active peptides (proMAPs) will be developed to couple protease activity to biomarker and drug release. Methods to correlate biomarker release patterns to protease activity profiles in 3D breast cancer models will be explored. The PROTECT platform can then rapidly be repurposed for precision drug delivery. The PROVES concept will combine the excellent properties of liposomes for drug delivery and the optimal combination of proMAPs, based on the protease activity profile retrieved from the LABS, for optimized protease-triggered liposomal drug release. Combined, the LABS and PROVES concepts represent a unique and comprehensive platform for diagnostics and personalized cancer therapy. The proposed work goes far beyond stat-of-the-art and will address a significant and real bottleneck that hampers drug development and exploitation of proteases as diagnostics and prognostic cancer biomarkers.

Keywords: protease,breast cancer,sensor,drug delivery,peptides,liposomes
Fascinating World of Researchers in the Age of Technology - Alliance with Citizens (FAWORIT 2022-2023)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Hungary
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 357803.57
EU funding (EUR): 296625.0
Participants: 5
Project status: CLOSED

The main objective of our proposal is to bring researchers closer to the general public, engage them with citizens and encourage the youth, especially girls, to embark on scientific careers. We will use a mission-oriented, impact-focused approach in order to address global challenges and provide innovative solutions. Researchers, their work and hobbies will be presented in an interactive way that educates the public, especially pupils about research and innovation. A special focus will be given to co-creation, the role of R&I in the society and the economy, and societal relevance of EU research policy and to improve science communication. Researchers to Schools pre- & post events will be organised throughout the two years in order to sustain pupils` interest raised and support teachers developing new entertaining approaches when educating priority topics such as digital, green and sustainable development, health, etc. The involvement of many different actors across various disciplines and sectors will achieve a high impact and make researchers` work familiar. Our main target group is students of age 6-26, but we aim to address all age groups with attractive programmes and demonstrate that both scholars and innovators can be discovered amongst us, and being a researcher is indeed cool and creative! Our venues cover the whole country. As the result of the awareness raising campaign several organizations will join the Researchers` Night, the most important science communication event in Hungary, thus contributing to the multiplication of the visitors. We have the experience of 11 years to reach our ambitious but realistic goal of getting 30000 people at our venues on the two-day event, but many more will attend at partners` venues that join later. Millions will see, hear or read about the NIGHT. At each venue, EU-related info points will be set up to raise awareness of the EU engagement in R&I through the participation of EU projects with a special focus on MSCAs.

Keywords: researchers closer to the public and schools,attractiveness of researcher career,rri,twin transition,green deal,societal relevance,women in science,edutainment,social media,eu randi visibility
Louis, the smart earplug for industry made in France (Safehear)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-07-01
End date: 2023-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Safehear has designed Louis: a new earplug for industrial and noisy environments. Our mission is to prevent diseases and accident cause of a lack of communication in industry. Safehear is a french startup of 8 people, we work on senses improvement solutions using embedded intelligence. Partners : ST Microelectronics, INRIA, BPI France, Efi Automotive (Axandus)

Keywords: industry,hearing protection,french startup,communication
Renewing Administration through Democratic Anchorage Reforms (RADAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,Estonia,France,Sweden,Italy,Romania,Germany,Montenegro
Call: The role and functioning of public administrations in democratic systems (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 2977972.75
EU funding (EUR): 2977972.75
Participants: 10
Project status: SIGNED

The RADAR project (Renewing Administration through Democratic Anchorage Reforms) aims to enhance the democratic governance of public services and public administrations. To construct legitimacy for public administration, it will focus on democratic anchorage, new narratives and education. RADAR’s first objective is to improve the understanding of the relationship between public administration reforms and democratic legitimacy. This will be achieved through a scoping review; multi-level statistical analysis of data from the European Quality of Government Index; a systematic analysis of emerging innovative solutions using a newly created database of innovation cases; and a comprehensive analysis of reform discourses. RADAR’s second objective is to examine under which conditions efforts to improve the democratic legitimacy of public administration reforms are effective. Using a combination of research methods including experiments, focus groups, and case studies, it will examine three types of initiatives that have shown the most promise: participation/co-creation, representative bureaucracy and experimental governance. The third objective is to translate the findings from RADAR’s research into concrete methods to increase the input and output legitimacy of public administration, allowing reforms and innovations to achieve results while respecting and strengthening democratic institutions. RADAR’s final objective is to make methods to democratically anchor reforms and innovations part of the education and training received by current and future civil servants and policymakers. With seven leading research institutes, two national schools of government, a Ministry at the core of public innovation, and an international NGO, the RADAR consortium represents a wealth of research and teaching experience. The partners are European leaders and innovators in their area of expertise, and have the ability to cover all 27 EU countries as well as the Western Balkans.

Keywords: bureaucracy,education,training,participation,representation
Numerical modeling of cardiac electrophysiology at the cellular scale (MICROCARD-2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: France,Italy,Germany,Norway
Call: Call on Centres Of Excellence For Exascale HPC Applications (HORIZON-EUROHPC-JU-2023-COE-03, 2023)
Start date: 2024-11-01
End date: 2027-04-30
Duration (months): 30.0
Total project cost (EUR): 4999300.0
EU funding (EUR): 2499650.0
Participants: 10
Project status: SIGNED

Cardiac function is coordinated by an electric system whose disorders are among the most frequent causes of death and disease. Numerical models of this complex system are mature and widely used, but to match observations in aging and diseased hearts they need to move from a continuum approach to a representation of individual cells and their interconnections. This makes the problem more complex, harder to solve, and four orders of magnitude larger, necessitating exascale computers. The EuroHPC-2019 MICROCARD project is developing a simulation platform that can meet this challenge, by a joint effort of HPC experts, numerical scientists, biomedical engineers, and biomedical scientists, from academia and industry. Our proposal is to establish a Centre of Excellence that will consolidate and scale up the MICROCARD results enabling digital twins of cardiac tissue. With a consortium gathering the core partners of MICROCARD, we will further develop MICROCARD's numerical schemes, moving to second-order spatial discretization. Based on MICROCARD results, we will develop mixed-precision preconditioners and data compression to reduce communication bandwidth. The highly successful efforts towards automated compilation of high-level model descriptions into optimized, energy-efficient system code for different CPUs and GPUs will be extended to upcoming architectures. We will continue efforts to robustify parallel remeshing software and add necessary functionality for parallel mesh partitioning and production of realistic synthetic tissue meshes needed for simulations. The platform will be benchmarked with realistic test cases and be made accessible for a wide range of users with tailored workflows. The platform will be adaptable to similar biological systems such as nerves, and several of our products such as improved solvers, preconditioners, remeshers, and partitioners will be reusable in a wide range of applications.

Keywords: cardiac electrophysiology,cardiac arrhythmia,mesh processing,exascale,solvers,preconditioners,runtime
Comparative HaplotypOmics of Parthenogenetic Plectus nEmatodes (CHOPPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Sexual reproduction is a costly but seemingly necessary trait in animals. However, species in diverse branches of the animal kingdom have secondarily reverted to asexual reproduction. In the roundworms (phylum Nematoda), this reversal appears particularly frequent, as parthenogenetic species have emerged in numerous genera. Species in the genus Plectus are obligately parthenogenetic, and are distributed in non-extreme and extreme environments across the globe. Mechanisms leading to the loss of sex, for example hybridisation, have received some attention, but are still poorly understood, in particular on the genomic level. This is in part due to the lack of sequencing and analysis tools for complex genomes of minute organisms. CHOPPE will generate chromosome-level collapsed and phased genome assemblies using latest assembly strategies for several species of Plectus and its closest sexual relative Anaplectus from diverse habitats. CHOPPE will develop new computational methods for generating fully phased assemblies of diverse non-model species. Collapsed assemblies, and haplotype assemblies of several Plectus and Anaplectus species generated in the project, will allow to decipher the genomic basis of their adaption in the context of parthenogenesis and extreme environments. The project will further investigate the reversal to sexuality of Plectus through crossing with heat induced males, and establish this genus as a new model for the study of parthenogenesis.

Keywords: genome assembly haplotypes parthenogenesis adaptation
Myopia control in the real world: treatments, target, timing, and terminus (CONTROL-MYOPIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Background: Myopia, or near-sightedness, is increasing dramatically all over the world, mostly due to higher levels of education and changing lifestyles of young generations. The expectation is that half of the world’s citizens will be myopic by 2050. Myopia-related complications later in life are a serious threat to vision and will increase the rates of blindness. Prevention strategies and pharmacological and optical treatments to delay progression of myopia in childhood are emerging, but most eye care professionals still do not control myopia due to inadequate information and unpredictable outcomes. Aim: To radically improve patient management in myopia by providing an agile, AI-based clinical decision support system stooled on a solid scientific basis of integrated multidisciplinary data. Approach: 1. To construct population-based reference centiles for eye growth and progression of myopia for screening and surveillance of myopia in young generations in Europe 2. To capture high-quality, long-term, prospective data from the real world on myopia control, and specifically gain evidence on timing, effectiveness, side effects, and acceptability of current treatment modalities in daily practice 3. To investigate patient profiles for poor response and adherence to myopia control 4. To predict the final outcome of myopia based on a plethora of potential predictors using advanced machine learning techniques 5. To develop the CONTROL-MYOPIA platform with a user-centred and highly interactive design which provides an accurate prediction of myopia outcomes with and without myopia control, and which recommends the right prevention and treatment for the right patient at the right time Impact: CONTROL-MYOPIA’s outcomes will have widespread impact on clinical care, patient participation, public health, design of clinical trials, research innovation, and policy changes

Keywords: reference centile charts,myopia,myopia control,patient management,clinical decision making,nearsightedness,machine learning,genetics,lifestyle,real world data,registry,artificial intelligence,blindness prevention,refractive error,axial length