Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transformation scenarios for boosting organic farming and organic aquaculture towards the Farm-to-Fork targets (OrganicTargets4EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Sweden,Belgium,Italy,France,Denmark,Hungary,Germany,Portugal,Romania,Austria,Greece,Switzerland
Call: Reaching the farm to fork target: R&I scenarios for boosting organic farming and organic aquaculture in Europe (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 3999768.75
EU funding (EUR): 3999768.75
Participants: 19
Project status: SIGNED

With the Farm-to-Fork Strategy (F2F), the EU has set targets of reaching at least 25% of the EU’s agricultural land under organic farming and significantly increasing organic aquaculture by 2030. The overall objective of OrganicTargets4EU project is to support the achievement of these targets. Based on an assessment of key drivers and lock-ins affecting the development of the organic sector, the project will set-up a multi-actor process to create possible scenarios for reaching the targets. The project is structured into two strands, which run from start to finish: •Production and Markets: the project will analyse where increases in organic farmland can be achieved, and the (socio-economic) impacts of these increases at the level of primary production, value chains and markets. The project will also provide evidence on the mechanisms that can drive demand for organic food and the impact of changing diets and food waste reduction on mitigating the reduced yields from organic production. •Knowledge and Innovation: the project will work towards an innovation ecosystem fit for achieving the F2F targets, recognising that the scale of the expansion envisaged will require a transformational approach. It will identify knowledge gaps and opportunities to strengthen advisory services. It will build capacity, and stimulate exchange of scientific and practice-oriented knowledge. Building on the CORE Organic network, it will increase and coordinate R&I investment for organic. OrganicTargets4EU will facilitate a multi-actor policy dialogue to assess the feasibility of the organic F2F targets and develop policy recommendations for the CAP, EU organic regulation, EU and national organic action plans, Horizon Europe, and horizontal legislation on inputs and public procurement. The policy recommendations will cover short-term options (up to 2027), the next policy reform from 2028 onwards, and a horizon scanning post 2030 for the whole next multi-annual financial framework to 2034.

Keywords: farm to fork strategy participatory foresight socio economic impact primary production markets knowledge exchange advisory services capacity building randi investments policy recommendations
ONdas DE Peniche (ONDEP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: United Kingdom,Spain,Norway,Netherlands,Portugal,Belgium,France,Italy
Call: Demonstration of sustainable wave energy farms (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-10-01
End date: 2030-03-31
Duration (months): 66.0
Total project cost (EUR): 25457323.75
EU funding (EUR): 18999514.01
Participants: 15
Project status: SUSPENDED

The untapped potential of wave energy emerges as a promising horizon projected to reach up to 1,800 TWh per year in Europe. However, full operational conditions of a wave energy farm are required to improve market confidence and increase the bankability and insurability of wave energy commercial projects. In this context, ONDEP aims at setting up a 2MW farm composed of 4 WaveRoller units connected to the grid in Peniche, Portugal. This will leverage +10 years of experience at this site - including two years of full-scale demonstration of the patented and certified WaveRoller unit (2019-2021). Over five years and a half, ONDEP aims at emulating the needs and technical challenges of future extra large-scale wave farms, while establishing a complete end-to-end European supply chain for GW-scale deployment in Europe. It also includes the first comprehensive environmental analysis spanning several decades for wave energy production. ONDEP is a pathway to scale up wave energy farms: in the short term and by 2030, the project expects to unlock 11 farms in 8 countries across 4 continents, with a cumulative 83 MW capacity (MoUs and support letters already signed) and a GWP <25 gCO2eq/kWh. Beyond 2035, the expected LCOE (<100€/MWh) will pave the way towards a sustainable blue economy creating up to 500,000 jobs in Europe. To achieve its ambitious goals, ONDEP involves 9 countries and 14 leading organisations covering the whole end-to-end value chain of the wave energy sector.

Keywords: wave energy farm,ocean energy,portugal,offshore,blue economy
WIDENING HIGH-THROUGHPUT PLANT PHENOTYPING ACROSS EUROPE: ADVANCING COLLABORATIVE KNOWLEDGE EXCHANGE AND TECHNOLOGY TRANSFER (PHENOWEX)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Türkiye,Cyprus,Germany,Italy,Netherlands
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 1436237.06
EU funding (EUR): 1436237.06
Participants: 5
Project status: SIGNED

PHENOWEX aims to enhance the scientific excellence and innovation capacity of two widening institutions from the Mediterranean Region, namely EGE (Türkiye) and CYENS (Cyprus), in the field of High-Throughput Phenotyping (HTP) with the assistance of top-class leading partners from across Europe. PHENOWEX will use the appropriate methodology to reach its four objectives which are; i) To enhance the scientific excellence level of widening countries, ii) To create a Sustainable network, integration, and dissemination, iii) To improve the innovation capacity of the widening countries via real-world pilot studies, and iv) To improve the project management and administration skills of widening partners. The widening partners, EGE and CYENS, will receive support from Wageningen Research (WR), the National Research Council of Italy (CNR), and Forschungszentrum Jülich GmbH (FZJ). These institutions possess outstanding scientific excellence and innovation capacity in high-throughput phenotyping (HTP) and plant physiology. The expected outcomes arising from the PHENOWEX entail a multifaceted enhancement of scientific excellence in HTP research within these widening countries. This involves the establishment and fortification of collaborative networks with vanguard organizations (e.g. EMPHASIS) currently at the forefront of this technology. Additionally, the project aspires to cultivate creativity and amplify the capacity for international project management in the context of HTP research, thus encapsulating the overall ambit of anticipated improvements. Moreover, one of the unique aspects of PHENOWEX is that it serves as a testament to the power of science diplomacy and international cooperation. While political issues persist between Cyprus and Türkiye, the collaboration between CYENS and EGE underscores the shared commitment to advancing agriculture, research, and innovation within the region.

Keywords: plant phenotyping,remote sensing,decision making,plant image analysis
Resolving and understanding the contributions of mesoscale eddies to climate prediction (PREDDYCT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Spain,United Kingdom,Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1998903.0
EU funding (EUR): 1998903.0
Participants: 3
Project status: SIGNED

Climate predictions are our most valuable tools to support socio-economic decision-making from regional to local scales and develop successful adaptation strategies. Their level of accuracy is determined by our understanding of the climate system and our capacity to simulate it correctly. While current prediction models exhibit high skill in predicting sea surface temperature in key regions – like the North Atlantic or the Tropical Pacific – from months to years in advance, their ability to predict the atmospheric circulation and through it the continental climate is undermined by structural model problems. These problems point to a misrepresentation of key processes and interactions. PREDDYCT focuses on the North Atlantic, the region where the structural problems manifest more clearly. Its aim is to bring a new fundamental understanding of the physical mechanisms that need to be realistically simulated to provide climate predictability to its neighbouring continents. The main working hypothesis is that mesoscale eddies – whose contribution is unresolved in current prediction models – are the key element. This is supported by the fact that in the North Atlantic region, resolving the effect of mesoscale ocean eddies and the atmospheric eddy feedback onto the midlatitude jet has been shown to critically improve the realism of air-sea interactions and their influence on the large-scale atmospheric circulation. In light of this, PREDDYCT will combine a new generation of predictions at ground-breaking resolutions, an innovative tuning framework to enhance their accuracy, and extensive process-oriented analyses to, for the first time, resolve and understand the contribution of mesoscale eddies to North Atlantic climate predictability. PREDDYCT’s new conceptual and methodological insights will pave the way for further forecasting advances at the global scale and contribute to achieve a long-awaited breakthrough in the realism and trustworthiness of climate predictions.

Keywords: climate prediction,high resolution climate modelling,air sea interactions and feedbacks,ocean and atmospheric dynamics
Spliceosomal Processes in Nucleomorphs (SPiN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

The "Splicing Processes in Nucleomorphs" (SPiN) project leverages the unique properties of nucleomorphs to explore in situ the nuclear architecture and gene expression at an unprecedented level. Using cutting-edge cryogenic electron microscopy (cryo-EM) techniques such as tomography, subtomogram averaging and single particle analysis, I want to provide novel understanding of how pre-mRNA splicing happens in the context of genome reduction. I will overcome the limitations of current cryo-ET studies of the nucleus that struggle with the large size and dense environment of typical eukaryotic nuclei. Nucleomorphs, with their small size, enable a more accessible and efficient approach to in situ studies, bypassing the need for complex sample preparation steps. The SPiN project is structured around three specific aims: (1) isolating intact nucleomorphs for comprehensive proteomics and transcriptomics and structural analysis, (2) purifying and structurally characterizing spliceosome complexes unique to nucleomorphs, and (3) visualizing the structural landscape of nucleomorphs to understand the spatial organization of gene expression targeting spliceosome structures for in situ structural determination. By establishing nucleomorphs as a powerful model for in situ studies, this project promises to uncover new insights into pre-mRNA splicing mechanisms and nuclear organization, with far-reaching implications across evolutionary biology, cell biology, and biotechnology. The potential for groundbreaking discoveries positions nucleomorphs as a transformative tool to advance our understanding of eukaryotic genome evolution and the mechanisms underlying nuclear processes.

Keywords: pre mrna splicing,spliceosome,nucleomorph,in situ,gene expression,cryo electron tomography,proteome
Breaking BArriers using Disruptive innate immunotherapy in cancer (BREAKING-BAD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 48.0
Total project cost (EUR): 2500000000.0
EU funding (EUR): 2500000000.0
Participants: 1
Project status: SIGNED

Trained Therapeutix Discovery (TTxD), a Dutch biotechnology company, is pioneering RIDE-001, a first-in-class lipoprotein-based nanobiologic therapy designed to treat solid tumours by harnessing the power of "trained immunity." This innovative therapeutic targets hematopoietic stem and progenitor cells in the bone marrow, reprogramming them to overcome the immunosuppressive tumour microenvironment. By inducing durable innate immune responses, RIDE-001 addresses the limitations of conventional immunotherapies that focus primarily on the adaptive immune system. RIDE-001 has reached TRL-6 and is supported by a robust intellectual property portfolio, ensuring a strong competitive edge. Preclinical studies in mice, rats, non-human primates, and ex vivo human immune cells demonstrate its ability to induce innate immunity, showing anti-tumour efficacy without off-target effects. Its strong single-agent activity and synergy with immune checkpoint inhibitors highlight its transformative potential for cancer therapy. Through the EIC Accelerator, TTxD aims to advance RIDE-001 into clinical trials, starting with a Phase 1 basket trial targeting metastatic colorectal, ovarian, head and neck, and lung cancers. Based on Phase 1 outcomes, a Phase 2a trial will focus on the most promising indication, evaluating RIDE-001 as a monotherapy and in combination with checkpoint inhibitors. These trials are critical milestones for securing an out-licensing agreement with a major pharmaceutical partner by 2029. Projected revenues for RIDE-001 in key markets are significant. By capturing up to 18-20% market penetration, annual revenues could reach €231 million by 2045, with cumulative revenues exceeding €1.6 billion. With EIC support, TTxD is poised to deliver a groundbreaking therapy that redefines the role of innate immunity in oncology and addresses urgent unmet needs for patients worldwide.

Keywords: innate immunotherapy trained immunity solid tumors nanobiologics
DIVERSIFY CCAM BY INTEGRATING THE EUROPEAN CULTURAL AND REGIONAL VARIATIONS IN THE DESIGN AND IMPLEMENTATION OF CITIZEN-FRIENDLY SYSTEMS TO FOSTER MOBILITY EQUITY (Diversify - CCAM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Sweden,Greece,Germany,Spain,Czechia,Belgium,Italy
Call: Integrating European diversity in the design, development and implementation of CCAM solutions to support mobility equity (CCAM Partnership) (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 3995551.25
EU funding (EUR): 3995551.25
Participants: 15
Project status: SIGNED

CCAM solutions face a significant challenge characterized by decreased societal demand due to their difficulty in effectively conveying their advantages within existing mobility systems and adapting to the diverse environments where citizens live, work, and conduct their daily activities. Diversify-CCAM has the clear objective to promote fair and accessible mobility in European regions by integrating cultural, geographical and policy aspects into the design, development and implementation of CCAM solutions. This initiative encompasses 6 European countries (Czech Republic, Greece, Italy, Germany, Spain, Sweden), collectively hosting 12 pilot sites dedicated to data collection and evaluation. In each country, there are two distinct areas under examination: one focusing on mobility of people within urban environments equipped with existing CCAM solutions and another focusing on mixed transport (people and small goods) solutions within rural or touristic areas primarily reliant on private cars. Diversify-CCAM will deepen our understanding of the diverse social contexts that influence the acceptance, adoption, and utilization of CCAM. Moreover, the project will study the surmount challenges and barriers hindering the effectiveness of shared services, especially in regions with unique geographical and cultural demands. The methodological approach involves the engagement of various user groups and stakeholders at the local level, extending their involvement to the European and international spheres through PAVE and our distinguished Stakeholder Board. This multifaceted involvement aims to positively influence public perception and reimagine the overall design and offerings of CCAM solutions. Ultimately, the project will develop a CCAM Diversification Tool (CCAM D-Tool) for transportation planners and a CCAM Diversity Observatory for the entire CCAM value chain, both focusing on achieving inclusiveness and equity within the European mobility ecosystem.

Keywords: mobility equity,citizens,user friendly
Smart Sensor Analog Front-End powered by Emerging Reconfigurable Devices (SENSOTERIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Netherlands,France,Switzerland
Call: Low TRL research in micro-electronics and integration technologies for industrial solutions (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3913573.75
EU funding (EUR): 3913553.75
Participants: 9
Project status: SIGNED

Our main objective is the development of a reconfigurable platform to accommodate both for a generic sensor interface as well as a dedicated sensor transducer element. The tunable analog front-end (AFE) interface should be enabled at the fine-grain level by emerging reconfigurable field effect transistor (RFET) and negative differential resistance (NDR) transistor technologies that provide co-integration capabilities with European 22nm CMOS processing technologies allowing for a More-than-Moore sensor technology approach. Being doping-free these two key enabling technologies provide a high potential gain for a large variety of sensor system requiring a low 1/f noise behavior ranging from solid-state sensors, such as photodiodes, to environmental monitoring for the automotive market, and physiological signal monitoring, such as cancer detection. Having naturally un-gated channel areas, reconfigurable field effect transistors are the perfect target vehicle for functionalized surfaces, e.g. for the detection of colorectal cancer (CRC) biomarkers, serving as a Reconfigurable Sensor Transducer (RST) for the healthcare sector. Together with the AFE, these transducers can be integrated into a CMOS as a use-case demonstration of the flexible platform. To sum up, in SENSOTERIC we will investigate smart sensing solutions in environmental monitoring and healthcare, where both the RST and the AFE utilize the capabilities of emerging RFET and NDR key enabling technologies.

Keywords: emerging devices reconfigurable electronics analog circuits smart sensors more than moore integration
Towards a smart, decentralised and democratic energy grid (EMS LLS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: European Innovation Procurement Awards
Action type: Recognition Prize
Countries involved: Netherlands
Call: Innovation procurement initiative (including implementation) category (HORIZON-EIC-2024-PRIZE-EIPA, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

Living Lab Scheveningen, part of the municipality of The Hague, has been working on the subject of smart energy grids for several years and is building its own smart electricity grid on the northern harbour head. Various municipal users, such as the Port Control Centre, an event power point and solar panels on municipal real estate, are already using the grid and the smart metering at a high level of detail. The next step is to further expand the electricity grid with physical and digital infrastructure, and the necessary control through an energy cooperative in which the users are united. In December 2022, a collaboration with grid operator Stedin was therefore launched to make the grid 'semi-autonomous', with data infrastructure, dashboarding, prediction models, control mechanisms and management software. With this, we want to greatly increase the flexibility in the electricity grid in order to offer a solution to grid congestion and to ensure that energy is used as much as possible where it is generated. This experiment provides important information for the realisation and operationalisation of these types of semi-autonomous grids, with opportunities to scale up across the entire city and region where Stedin is active, as well as as an example for other grid operators. We have opted for an innovative way of tendering (the competitive dialogue, in which there is room for discussions between client and suppliers) because the desired solution is not available ready-made. For this reason, dialogue with the market parties was crucial. In the end, a consortium of two suppliers was contracted. They are building a completely open source solution that is available online to everyone. With this solution, which consists of hardware and software, we can predict (among other things) energy consumption, plan it and distribute it fairly among the users.

Keywords: energy management open source democratic sustainable