Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of an effective and safe systemic Myc inhibitor for the treatment of multiple cancer types. (SYST-iMYC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-07-01
End date: 2019-12-31
Duration (months): 18.0
Total project cost (EUR): 148875.0
EU funding (EUR): 148875.0
Participants: 1
Project status: CLOSED

Current cancer therapies target redundant cellular functions often compensated for by cancer cells, resulting in resistance to treatment. Here we propose an innovative approach to inhibit Myc, a non-redundant and “most-wanted” therapeutic target for human cancer. Targeting Myc has long been considered unfeasible because of the potentially catastrophic side effects in normal tissues. Against this dogma, we showed that Myc inhibition by Omomyc, a Myc mutant designed by Dr. Soucek, has a dramatic therapeutic impact in multiple mouse models of cancer, while causing only limited and reversible side effects. Critically, there is no emergence of resistance. Thanks to the ERC-2013-CoG n° 617473, we discovered the unexpected cell-penetrating properties of the purified Omomyc polypeptide. Moreover, we found that it is anti-tumorigenic after local (intranasal) delivery to mouse models of lung and brain tumors, and could therefore become the first clinically-viable direct Myc inhibitor. With this ERC PoC, we propose to develop a new drug based on an Omomyc variant that enables systemic treatment of several cancer types including lymphoma, breast, and melanoma. In all these cancers Myc contributes to multiple aspects of tumorigenesis including immune suppression. At the end of this project we will have a patent protected therapeutic polypeptide active in vitro and in vivo and ready to enter clinical trials Phase I/II in patients and to continue its commercialization. The forecasted peak revenue for such first-in-class drug in those indications reaches 2.612 M€ annually. With this ERC PoC project we will achieve essential milestones to develop this innovative therapeutic polypeptide by establishing the feasibility, including a commercial data package and cost estimations for the industrial production. Passing these milestones will de-risk the product and increase its value and probability of reaching the market by making it ready to be transferred to a spin-off company.

Keywords: cancer,therapeutic polypeptide,myc inhibition,de risking,viability study,ipr strategy,business plan
Cold Molecules in Cavities (CoMiC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Here we propose a radically new way to control chemical reactions on the quantum level. The Experienced Researcher (ER) will combine his long-standing expertise on cavity quantum electrodynamics (CQED) with the field of ultracold chemical reactions, in which the host is one of the leading pioneers. We want to drive a photo-chemical reaction (photoassociation) within an optical cavity and in this way gain control over the reaction (objective 1). For this, we use the control over spontaneous photon emission by an optical cavity, as has been done with single atoms. This paves the way towards novel fascinating effects like superradiant chemistry, where a chemical process is enhanced due to quantum statistics. Furthermore, the optical cavity will be used as an ultrasensitive molecule detector of a new quality by detecting them without disturbing their quantum state (objective 2). This novel interdisciplinary combination of physics and chemistry will open up a new research field, where the ER will demonstrate scientific innovation and independence.

Keywords: cold chemistry,cavity quantum electrodynamics,ultracold atoms
The EEG Dementia Index – Fast and Affordable Dementia Diagnosis (BTD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Malta
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Dementia is a devastating neurodegenerative disease that causes tremendous suffering for patients and their families. The disease’s relentless progression leads to a loss of all mental abilities, making patients completely dependent on constant care and supervision. Even though the disease is incurable, there are treatments available that can postpone the patient`s mental decline for a few years. Treatment is most beneficial if prescribed early, as soon as the first symptoms occur. However, the most common diagnostic methods, such as brain scanners, cerebrospinal fluid testing and clinical observation, either cannot detect early brain changes, are too expensive to be available for large-scale early diagnostics, are invasive, or can be administered only by specialists. Current diagnostic practice delays the diagnostic time by several years, making treatment much less effective. Due to a rapid mental decline, patients are robbed of the chance to decide on their own personal, legal and financial matters. We propose a novel approach for early dementia diagnosis by using electroencephalography (EEG). EEG measures the electrical activity of the brain and is regularly used in clinical practice to diagnose epilepsy. However, EEG has enormous diagnostic potential that goes beyond epilepsy, but existing clinical EEGs are too bulky and difficult to use. We are therefore developing a mobile, easy-to-use EEG for early dementia diagnosis. Since EEG was invented 100 years ago, the device itself is not a novelty and it is not difficult to build. But it is very difficult to find a biomarker for dementia in the acquired brain signals – we have managed to do just that by developing and successfully testing EEG-based algorithm for dementia diagnostic. This algorithm calculates recorded brain signal data and returns a simple score that indicates the likelihood that a person is suffering from dementia. Physicians can use it to diagnose patients early and prescribe treatment sooner.

Keywords: dementia,early detection and diagnosis,brain signals,neuroscience,neurology,ageing well
Modalities in Substructural Logics: Theory, Methods and Applications (MOSAIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria,Spain,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Australia,South Africa,Argentina,Spain,Switzerland,Poland,Poland,France,Czechia,Czechia,United States,Netherlands,Netherlands,United Kingdom,Brazil
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-09-01
End date: 2026-04-30
Duration (months): 56.0
Total project cost (EUR): 1016600.0
EU funding (EUR): 1016600.0
Participants: 34
Project status: SIGNED

Modal logics are a family of formal systems based on classical logic which aim at improving the expressive power of the classical calculus allowing to reason about “modes of truth”. The aim of the present proposal is to put forward a systematic study of substructural modal logics, understood as those modal logics in which the modal operators are based upon the general ground of substructural logics, weaker deductive systems than classical logic. Our aim is also to explore the applications of substructural modal logics outside the bounds of mathematical logic and, in particular, in the areas of knowledge representation; legal reasoning; data privacy and security; logical analysis of natural language.

Keywords: modal logics,substructural logics,proof theory,residuated lattices,kripke semantics,duality theory,coalgebras,applied logic,computational linguistics
COMPostable capSULE for instant coffee delivery based on an innovative chemical functionalization of biobased plastics (COMPSULE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Italy,Italy,Italy
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-11-01
End date: 2016-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

Compsule is a compostable capsule designed for instant espresso coffee machines such as ones produced by Lavazza and Nespresso, that operates at a high temperature and pressure. Compsule aims to contribute to reduce the amount of recyclable material being sent to landfills as a result of the increased use of capsuled coffee. In Italy alone over 1 billion plastic coffee capsules are consumed annually. Albeit being made of 100% recyclable materials, coffee capsules are barely recycled due to the time and effort required in cleaning and sorting the capsule’s components after use. Point Plastics have developed an innovative chemical additive that when mixed with bioplastics increases their thermal stability, making them compatible for extreme operational applications such as espresso coffee extraction. This process technology has a great impact on biobased polymer producers enabling a wider market share in fields impossible to target today. Compsules will be able to be disposed of with other food and green waste that is commonly collected by municipalities within the European Union, thus reducing the amount of waste being sent to landfills by hundreds of thousands of tonnes per year. For coffee producers the capsules will reduce their carbon footprint and respond to the demand of an increasingly environmentally conscious consumer base. For the capsule printing manufacturers, the Compsule does not impose any new machinery on their current production line as the Compsules can be manufactured similarly to the polymers currently used. For capsuled coffee drinkers the Compsules are both airtight and designed to fit user’s current machines, allowing them to be easily adopted. The Compsules have been developed and validated in an operational environment (TRL 8) and now require funding to outline a sound business development and industrial implementation and validation plan.

Keywords: chemical additive,compostable capsule,instant coffee,bioplastic,waste reduction
Mass-Independent SulFate IsoTopes (MISFIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The discovery of sulfur mass-independent isotopic fractionation (S-MIF) in Archean rocks older than 2.4 billion years and in stratospheric sulfate from explosive volcanic eruptions provides unique constraints on fundamental questions regarding the late oxygenation of the atmosphere, the shift from an anaerobic to aerobic environment for life, and the reconstruction of the impact of volcanic eruptions on atmospheric oxidizing capacity and climate, respectively. However, recent controversy has emerged regarding the origin of S-MIF and there is no general consensus of it. This project will explore potential processes responsible for S-MIF signals in atmospheric sulfate by using a new set of chamber experiments on SO2-oxidation related production of S-MIF, considering environmental conditions as close as possible to those of the stratosphere and the presupposed Archean atmosphere. A S-MIF isotope scheme will be developed and incorporated together with the Oxygen-MIF isotope scheme into a global 3-D chemical transport model. The model will be used to investigate the magnitude and direction of the multiple sulfur and oxygen isotope signals produced in atmospheric sulfate, strengthening the ground on which the MIF isotopic markers are used to infer information on the climate evolution of our planet. This project capitalizes the host's knowledge and experience in theory and application of MIF, method development for MIF analysis and photolysis experiments on MIF, the fellow's experience in MIF analysis, method development and chemical modeling, and the research facilities in host and secondment institutes. The fellow will gain S-MIF knowledge, new experimental skills, and strengthened state-of-the-art modeling skill. Such new knowledge and skills will significantly add to the fellow's career development. The bidirectional transfer of knowledge will diversify the fellow and the host's competence and constitute a key ingredient in pursuing the goals of this project.

Keywords: mass independent fractionation,sulfur isotopes,oxygen isotopes
Secure Hardware-Software Architectures for Robust Computing Systems (SHARCS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Israel,Sweden,Greece,Netherlands,Netherlands,Gibraltar
Call: Cybersecurity, Trustworthy ICT (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3105762.5
EU funding (EUR): 3105762.5
Participants: 8
Project status: CLOSED

Developing new security paradigms, architectures, and software, for more secure and trustworthy ICT systems and services has clear social, scientific, and market motivation. This motivation is becoming stronger due to the changing threat landscape; over the past decade we are witnessing an ever-increasing amount of cyberattacks on the Internet. We believe that to advance the field of cybersecurity, we must act proactively and in synergy, instead of being reactive to cyberattacks. We propose SHARCS, a framework for designing, building and demonstrating secure-by-design applications and services, that achieve end-to-end security for their users. SHARCS will achieve this by systematically analyzing and extending, as necessary, the hardware and software layers in a computing system. This holistic approach is necessary, as no system can truly be secure unless every layer is secured, starting from the lowest one. We will measure the effectiveness of the SHARCS framework by using it on a diverse set of security-critical, real-word applications. The applications have been chosen from three different domains, medical, cloud and automotive, to demonstrate the platform independence capabilities of SHARCS. SHARCS will provide a powerful foundation for designing and developing trustworthy, secure-by-design applications and services for the Future Internet.

Keywords: secure by design,end to end security,hardware security,secure hardware,secure processor,medical applications,automotive applications,cloud applications,legacy applications
Polymeric nanocoating for tight and strong adhesion between challenging combinations of metals and plastics (AdheSurf)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Denmark
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Radisurf developed an industrial and stable process to create an adhesive layer on metal surfaces to efficiently adhere plastic parts. This process is the first solution offering the possibility to join strongly metals and plastics trough an ultrathin and tight interface. The use of plastics adhered onto metals to take advantage of both types of materials is highly desired in specific applications, e.g. to prevent corrosion, reduce friction or weight, repel dirt, and increase the biocompatibility and safety of components. Metal-plastic joining is complex and challenging, and the quality and effectiveness of the joining methodology is of utmost importance, both for safety and economic reasons. Industries such as medical devices, electronics, automotive, design, off-shore, food/beverage machinary are continuously looking for cost-efficient strategies to combine dissimilar materials. RadiSurf aims to pursue a major opportunity in the adhesives market by targeting applications where there are no solutions available or the few existent exhibit inferior performance, or as replacement of complex and difficult methodologies (often too expensive) that do not satisfy completely the industries. The technology (patent pending) is capable to bond plastic to metal with properties and safety not reachable by any adhesive system currently available in the market. AdheSurf adhesive layer is processed in mild conditions and it is a clean process not requiring demanding conditions. AdeSurf technology will be highly competitive not only in terms of efficiency but also regarding costs – upon established in the customers production lines with minor adaptations, the quantity of consumables needed will be very low and most of the chemical may be re-used. With our solution, industries will have the opportunity to improve the quality of their products or even develop products with new designs or new combinations of metals and plastics.

Keywords: adhesives,molecular adhesives,metals,plastics,coatings,polymer coatings
Synergistic engineering of anti-tumor immunity by synthetic biomaterials (ImmunoBioSynth)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Immunotherapy holds the potential to dramatically improve the curative prognosis of cancer patients. However, despite significant progress, a huge gap remains to be bridged to gain board success in the clinic. A first limiting factor in cancer immunotherapy is the low response rate in large fraction of the patients and an unmet need exists for more efficient - potentially synergistic - immunotherapies that improve upon or complement existing strategies. The second limiting factor is immune-related toxicity that can cause live-threatening situations as well as seriously impair the quality of life of patients. Therefore, there is an urgent need for safer immunotherapies that allow for a more target-specific engineering of the immune system. Strategies to engineer the immune system via a materials chemistry approach, i.e. immuno-engineering, have gathered major attention over the past decade and could complement or replace biologicals, and holds promise to contribute to resolving the current issues faced by the immunotherapy field. I hypothesize that synthetic biomaterials can play an important role in anti-cancer immunotherapy with regard to synergistic, safe, but potent, instruction of innate and adaptive anti-cancer immunity and to revert the tumor microenvironment from an immune-suppressive into an immune-susceptible state. Hereto, the overall scientific objective of this proposal is to fully embrace the potential of immuno-engineering and develop several highly synergistic biomaterials strategies to engineer the immune system to fight cancer. I will develop a series of biomaterials and address a number of fundamental questions with regard to optimal biomaterial design for immuno-engineering. Based on these findings, I will elucidate those therapeutic strategies that lead to synergistic engineering of innate and adaptive immunity in combination with remodeling the tumor microenvironment from an immune-suppressive into an immune-susceptible state.

Keywords: immuno engineering
Exosomes as microenvironmental cue for engaging mesenchymal stem cells in osteosarcoma progression (S-OS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-05-03
Duration (months): 24.0
Total project cost (EUR): 165598.81
EU funding (EUR): 165598.8
Participants: 2
Project status: CLOSED

Osteosarcoma (OS) is a very aggressive malignant bone tumor that develops primarily during childhood and adolescence. It is characterized by rapid growth, a strong tendency for recurrence and an extremely high metastatic potential. In the last three decades OS survival in the presence of metastasis has stagnated at a dismal 30%, clinical trials proved unsuccessful and no major breakthrough in the treatment of OS has been reported. To stop OS mortality, alternative therapeutical approaches urgently need to be explored. Studies into the molecular and cellular events underlying OS revealed complex and heterogeneous genetic alterations, which challenge the prospect of finding and exploiting an unique molecular driver underlying OS. Because OS onset occurs at sites of rapid bone growth during the adolescent growth spurt, microenvironmental factors and tumor stroma may have a defining role in OS development and progression. Surprisingly, the intercellular cross-talk between OS cells and components of the tumor stroma, in particular mesenchymal stem cells (MSCs), have been poorly investigated. Here I intend to demonstrate that tumor secreted vesicles called “exosomes” function as a key microenvironmental factor in OS progression by controlling tumor-stromal cells interactions. Specifically, we aim to explore whether MSC become pro-tumorigenic and pro-metastatic upon interaction with OS exosomes in bioluminescent mouse xenograft models. To identify the molecular signals (i.e. proteins and regulatory RNAs) in OS exosomes responsible for altering MSC behavior, we will employ state-of-the-art proteomics and deep-sequencing techniques. Finally, by means of functional assays we wish to discover the mechanisms by which OS exosome “educate” MSCs. The identification of and interference with this completely unexplored layer of communication will lay the groundwork for novel therapeutical approaches to stop OS high mortality rate.

Keywords: osteosarcoma,mesenchymal stem cells,exosomes,tumor microenvironment,intercellular communication,in vivo monitoring,deep sequencing