Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Digital Finance - Reaching New Frontiers (DIGITAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands,Austria,Italy,Lithuania,Romania,Luxembourg,Switzerland,Greece,Belgium,Germany,Poland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 4014917.49
EU funding (EUR): 3792542.4
Participants: 22
Project status: SIGNED

A competitive European financial sector is vital for the modernisation of the European economy across sectors and to turn Europe into a global digital player. We have identified the five most pertinent areas within this domain: Towards a European financial data space; Artificial intelligence for financial markets; Towards explainable and fair AI-generated decisions; Driving digital innovations with Blockchain applications; Sustainability of Digital Finance. For this purpose, we have gathered an internationally recognized network consisting of nine leading European Universities (WU Vienna, University of Twente, Bucharest University of Economic Studies, Babes-Bolyai University, Bern Business School, Kaunas University of Technology, University of Naples, University of Poznan, University of Kaiserslautern-Landau), all ranked among the top 200 universities globally in their fields, three major international corporations (Swedbank, Deutsche Bank and Raiffeisen Bank) with a significant R&D presence across Europe, two SMEs (Cardo AI and Royalton Partners) being some of the most innovative ones in their field, three large and internationally renowned research centres (ARC Greece, EIT Digital and Fraunhofer Institute Germany), the Bank for International Settlements and the European Central Bank, as one of the seven principal decision-making bodies of the European Union and the Euratom as well as one of the world's most important central banks. The results of the research carried out within DIGITAL are of substantial interest to three leading European-wide research networks that our members either lead or serve on the management committee for: COST Action CA19130 (240 researchers across 39 European countries), ECMI and the European Consortium of Innovative Universities (13 European Universities). It is only through a network that incorporates the expertise of all distinct shapers of the financial industry, that we can see a comprehensive shift towards innovation and digitalization of a sector that is notoriously averse to change.

Keywords: digital finance,fintech,sustainable finance,data,explainable artificial intelligence,blockchain,artificial intelligence
Combustion of liquid ammonia, assisted by plasma discharges, as a novel and clean energy conversion method (CAIPIRINH3A)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: Greece,United Kingdom,France,Sweden,Italy
Call: Emerging energy technologies for a climate neutral Europe (HORIZON-CL5-2024-D2-01, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 2497861.25
EU funding (EUR): 2497861.25
Participants: 11
Project status: SIGNED

CAIPIRINH3A aims to overcome the technical barriers, hindering the uptake of ammonia as an alternative fuel, by developing and demonstrating an entirely novel technological concept: The Plasma Mist Ammonia (PlasMi-NH3) burner - a first of its kind, plasma-enabled, self-learning combustor, burning efficiently liquid ammonia with ultra-low NOx emissions. Leveraging detailed and accurate kinetic models, innovative injectors, non-equilibrium plasma systems for plasma assisted combustion and tailored combustion control strategies, CAIPIRINH3A will generate a truly vibrant and multiphase cocktail of chemical species which will activate multiple synergetic effects for enhanced combustion, in a smart framework. The targeted performance metrics are outstanding and go far beyond current paradigms: a) Thermal efficiency comparable to conventional diesel engines (~40%) b) Tier 4 NOx emissions (≤7.5 g/kWh). c) > 50% decrease in ignition delay and extension of the flammability limits by >20%. d) Near zero ammonia concentration in exhaust (<10 ppm). The technological feasibility and future potential of CAIPIRINH3A’s concept will be investigated through extensive testing at TRL4 and holistic impact assessment studies. Seamlessly integrated in a future clean ammonia economy and in line with strategic EU action plans (Fit for 55, Green Deal), CAIPIRINH3A holds promise for a sustainable future for our societies with vast environmental and socioeconomic impact in the power generation and all transportation sectors. During the project this promise will be fostered through targeted communication, and dissemination actions as well as the development of tailored business models for future exploitation. Hence, CAIPIRINH3A paves the way for a disruptive solution, which is eminent and urgent, towards the re-orientation of the energy conversion sector from fossil fuel-based to carbon free-based combustion systems and the ultimate goal of climate-neutral Europe by 2050.

Keywords: ammonia combustion,alternative fuels,plasma assisted combustion
Developing self-assembling cyclodextrins to tackle the cytopathic activity of respiratory pathogens (CD-ResVir)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,Hungary,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-11-30
Duration (months): 30.0
Total project cost (EUR): 244893.6
EU funding (EUR): 244893.6
Participants: 3
Project status: SIGNED

The covid-19 pandemic has arisen awareness about the importance of developing tools to fight viral infection. However, there is still a lack of products to be used by the public as preventive systems against respiratory pathogens. Different systems have been developed to target SARS-CoV-2 using its affinity for different ligands. However, a multivalent presentation of these ligands is necessary to overcome their low affinity, which often implies complex structures difficult to synthesise and characterise. CD-ResVir aims to overcome those challenges. Our group has a wide experience in the exploitation of cyclodextrin (CD) conjugates to create self-assembling systems. These can be functionalised with a ligand to target a pathogen, leading to a multivalent supramolecular scaffold. The great advantage of supramolecular assemblies over covalent strategies is their structural adaptability to the target, i.e. the assembly will adopt the most stable state, the one with maximal interactions. It is also very simple to mix self-assembling components to optimise the effect. In preliminary experiments, we have obtained robust data proving that a sialic acid-functionalised CD scaffold could offer protection to cells exposed to SARS-CoV-2, which has never been proved before with a supramolecular assembly. Here, we propose to optimise the system and go beyond, expanding the scope of respiratory infections that could be addressed, targeting different respiratory viruses and bacteria. The Chemical Biology processes behind this application will be studied, from the atomic level (interactions between CD and SARS-CoV-2 receptors) to the microscopic level, (templating effect of a virus for the self-assembly of our CD system). Pursuing a groundbreaking preventive nasal spray against respiratory infections, we have established a strategic partnership with an industrial collaborator. This will facilitate the transition of our research findings from the laboratory to the industrial setting.

Keywords: self assembly,anti adhesion
HARMONY: Harmonised Protocols for Transnational Environmental Impact Assessment & Emergency Management (HARMONY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Innovation actions
Countries involved: Greece,Spain,Italy,Belgium,Austria,Portugal,Bulgaria,North Macedonia,Kosovo
Call: Harmonised / Standard protocols for the implementation of alert and impact forecasting systems as well as transnational emergency management in the areas of high-impact weather / climatic and geological disasters (HORIZON-CL3-2024-DRS-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 3458956.5
EU funding (EUR): 2999943.0
Participants: 16
Project status: SIGNED

The HARMONY project aims to advance excellence in standardization by developing harmonized protocols for comprehensive disaster risk management, encompassing Prevention/Mitigation, Preparedness, Response, and Recovery. Its core vision is to create a unified framework that transcends the current siloed approaches, enabling an integrated and coordinated assessment of impacts, risks, and interactions of climate-related and geological hazards across sectors and borders. By leveraging cutting-edge technologies and fostering collaboration among scientists, emergency responders, and policymakers among others, HARMONY seeks to enhance early warning systems, optimize response mechanisms, and support recovery strategies. This will contribute to building a climate-resilient society, capable of addressing the increasing intensity and frequency of disasters while minimizing their socio-economic impacts. By focusing on transnational collaboration, the project integrates novel technologies such as Earth observation, AI-driven predictive models, and GIS-based decision support systems. Large-scale pilot tests will be conducted in Spain-Portugal, Kosovo-North Macedonia, and Bulgaria-Greece, targeting climate-related and geological disasters including wildfires and floods. In addition, the project will build on a cohesive capacity building programme and replication guidelines to support scaling up of the proposed systemic approach across different areas in Europe.

Keywords: disaster resilience,harmonised protocols,transnational collaboration,climate change,emergency management,vulnerability assessment
Valorising magnetometry in cells (Diamond Sense)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-10-01
End date: 2024-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Magnetic resonance spectroscopy (NMR or ESR) and magnetic resonance imaging (MRI) are widely used. However, magnetic resonance signals are low in energy and thus difficult to detect. These techniques are expensive and typically only offer millimeter down to micrometer resolution. Diamond magnetometry potentially offers a solution. The technique is based on a quantum effect and allows even the detection of single electron spins. While the technique is already used for a few years in physics, during my ERC project this powerful tool was utilised for the first time to measure metabolic activity in living cells. The aim of this project is to explore the commercial potential of these results and - if it is deemed feasible - found a start-up company for exploitation. As a first application we will investigate free radical generation. These molecules play a key role in many biological processes including cell communication, immune responses or ageing. Additionally, they are an indicator for stress and thus play a role in many diseases including cancer, cardiovascular diseases or viral and bacterial infections. Despite their relevance and the fact that free radical generation is often an early sign of disease, they are rarely used as biomarkers since they are notoriously difficult to measure. In this project we will build a prototype (to be patented) that can be used for demonstrations to customers. This will be done on close collaboration with a user committee in order to meet the customer expectations. To demonstrate the usefulness to customers for diagnosis we will conduct test measurements . Further, we will assess whether a business model based on a product or based on services or a hybrid business model containing both is most promising.
Decoding Structural Dynamics of Charge Transfer in Avian Cryptochromes by Time-Resolved Crystallography (CRY TRSX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-01
End date: 2028-04-30
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

Charge transfer is crucial in many biological processes, including photosynthesis, respiration, and DNA repair. While the kinetics of charge transfer are well studied, the associated protein structural dynamics that guide these reactions remain largely unexplored. This proposal aims to uncover, for the first time, the protein structural rearrangements that occur during charge transfer events, with a particular focus on avian cryptochromes involved in magnetoreception. Our primary objective is to reveal the structural response of two cryptochromes during charge transfer events using cutting-edge time-resolved serial crystallography (SX) at X-ray free-electron lasers (XFEL) facilities. We intend to elucidate the structure and dynamics of the radical pair state in non-magnetoactive ClCRY4 from non-migratory pigeon (Columba livia) (Objective 1) and magnetoactive ErCRY4 from night-migratory European robin (Erithacus rubecula) (Objective 2). Through comparative analysis of the two samples, we aim to identify the structural adaptations that correlate with their differing biological responses to magnetic fields. We hypothesize that highly directed structural rearrangements in proteins occur for stabilizing charge transfer states. This contrast current textbook knowledge. By focusing on radical pair states in cryptochromes, our comparative study between ErCRY4 and ClCRY4 will enable us to determine whether and how structural adaptations are aligned with their biological functions. This research is poised to make a significant impact in charge transfer theory, and will provide the first structural basis to understand magnetosensing in crpytochromes. We anticipate establishing a new paradigm in which protein structural fluctuations actively drive charge transfer reactions, and may reveal evolutionary optimizations in how cryptchromes have facilitated this for optimization of their sensing functions.

Keywords: time resolved serial crystallography,protein structural dynamics,avian cryptochromes,magnetosensing,charge transfer
Building Land Degrowth Transitions (BuiLDT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

The Building Land Degrowth Transitions (BuiLDT) research project is a critical analysis of the role of agrarian movements in the creation of forms of livelihood and work that do not contribute to dominant capitalist relations of production, exchange, and consumption. Through an inquiry into the material and ideological aspects of social movements' relations with the land, this research elaborates the potential of movement social relations and economies to ameliorate some of the most pressing challenges of modernity, namely the ongoing exploitation of workers as well as non-human life for industrial food production and extraction of natural resources. BuiLDT integrates ethnographic methods in Indonesia with a comparative analysis of movement organizations in California, Amazonia, and Catalonia, focusing on places of political mobilization that have gone beyond resistance and conflict to establish spaces of alternative production and exchange with strong resonance with theorized post growth and degrowth trajectories of development. Specifically, this research asks how social movements can contribute to building degrowth transitions in the countryside through reworking the forms of access, control, and productive capacities of the land. Drawing on theories from degrowth and social movement studies, BuiLDT uses ethnography and spatial history methods to understand how movements create points of leverage that enable change, and how these movements are then able to establish low-carbon and non-capitalist economies. Supervision by Professor Giorgos Kallis and affiliation with the Institute for Environmental Science and Technology at the Autonomous University of Barcelona (ICTA-UAB) will provide me with leading training and career development in ecological economics, political economy/ecology, and degrowth research. In turn, I will bring expertise in agrarian change, social movements, and ethnographic approaches to ICTA and the European research community.

Keywords: degrowth,agrarian change,social movements,political transformation,alternative economies
Autonomous Longtime Aquatic Biodiversity and Ecology Monitoring Robot (BioDiMoBot)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Austria,Italy,Belgium,United Kingdom
Call: Digital for nature (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 8338518.75
EU funding (EUR): 7999593.75
Participants: 7
Project status: SIGNED

The BioDiMoBot project will deliver a system for autonomous, long-term robotic assessments of aquatic biodiversity and ecology. This project will develop an innovative measurement system to monitor biodiversity and provide insight into the drivers of ecosystem degradation. Additionally, it will assess organismic and environmental stress levels by using novel biohybrid sensors. With the BioDiMoBots' ability to perform autonomous and automated multimodal long-term data collection, the project will create a user-friendly robotic tool that provides detailed insights into the ecological health of aquatic environments. The project will be driven by the needs of potential stakeholders such as researchers, small and medium-sized enterprises (SMEs) in water-related industries and policy makers. Field operations will demonstrate the transformative power of the BioDiMoBot systems by monitoring aquatic ecosystems over a long period of time. The collected data will be highly accessible to enable interdisciplinary collaboration between scientists, society and policy makers. We will respond to the need to disseminate the new methodology to a wide audienThe proposed "BioDiMoBot" project aims to enhance Biohybrid sensors focusing on biodiversity measurement. Key goals include tailoring sensors for comprehensive water column investigation, ensuring long-term autonomy, establishing efficient data transfer, and integrating classical aquatic and biohybrid sensors for ecosystem evaluation. The robotic system comprises a "surface unit" with solar cells for energy and communication, a "ground unit" for microbial activity investigation, ropes connecting these elements, and "rope-climbing modules" with additional sensors for sampling. This integrated system offers a precise and adaptable solution for biodiversity monitoring. Emphasis will be placed on advancing the concept of "biohybrid robots" through market analysis, stakeholder engagement, and company founding.

Keywords: biodiversity,ecology,autonomous robotic systems,biohybrid sensors,mobile sensor solutions,climate change,aquatic environments,aquaculture,life form detection,big data,artificial intelligence
A novel approach for studying biological proton transfer: Protein incorporation of noncanonical amino acids carrying a light-triggered proton donor and proton acceptor (ProtonsInProteins)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2190000.0
EU funding (EUR): 2190000.0
Participants: 1
Project status: CLOSED

Proton transfer (PT) reactions within proteins are fundamental in biological systems, such as within ATP production. To date, there are no direct means to measure specific PT pathways within proteins, and most research is based on following the end-product of the PT reaction across a natural proton pathway. Here, our goal is to develop a novel way to directly measure PT within proteins. Our new approach is based on placing proton donors and acceptors in specific places within proteins, in which the PT will be initiated only after light excitation of the system. To do so, we introduce here two noncanonical amino acids (ncAA) we developed, with a photoacid and a photobase as their residues that serve as the proton donor and acceptor, respectively. Our hypothesis is that the strong light-triggered driving force of PT in the excited-state (of ~11 pKa units) will initiate PT along the pathway from donor to acceptor. In the first objective, we will use our new ncAA with solid-phase peptide synthesis to design several peptide systems that will allow us to decipher the role of specific amino acids, the peptide structure, and the role of water in PT across the peptide using various ultrafast spectroscopy. In the second objective, we aim to design a mutually orthogonal system for the insertion of our two ncAA into a single protein. In our third objective, we plan to use our new experimental system for answering a unique set of questions in the field of biological PT that could not have been answered before, focusing on the systems of ATP synthase transmembrane complex and the soluble carbonic anhydrase enzyme. Our new approach is groundbreaking in the way we study and understand PT in biology and will enable researchers completely new capabilities resulting in fascinating new discoveries. Moreover, our new system can be translated into other fields in biology that require the local change in proton concentration within proteins.

Keywords: biophysics,proton transfer,genetic code expansion,ultrafast spectroscopy