Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sino-EU Soil Observatory for intelligent Land Use Management (SIEUSOIL)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Belgium,Hungary,China,Hungary,Belgium,Poland,Switzerland,Greece,Greece,Latvia,Czechia,Czechia,Czechia,Portugal
Call: Highly efficient management of soil quality and land resources (H2020-SFS-2018-2, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 4985475.0
EU funding (EUR): 4985475.0
Participants: 25
Project status: SIGNED

SIEUSOIL will design, implement and test a shared China-EU Web Observatory platform that will provide Open Linked Data to monitor status and threats of soil and assist in decision making for sustainable support of agro-ecosystem functions, in view of the projected climate change. The Observatory platform will through customizable modules support the wise management of soil at field level and will provide showcase of good practices on soil management both for EU and China. The final target will be to support sustainable management of soil, increase land productivity sustainably, reduce crop yield variability across time and space, and support the policy formulation process. Innovative practices and tools will be tested in SIEUSOIL and their impact will be assessed for improved soil fertility and land suitability.
Active Magnetorheological Elastomers: from Hierarchical Composite Materials to tailored Instabilities (MAGNETO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2021-03-31
Duration (months): 72.0
Total project cost (EUR): 1499206.25
EU funding (EUR): 1499206.25
Participants: 1
Project status: CLOSED

In recent years, there has been an increased effort by scientists to obtain new composite materials with extreme properties. Inspired by natural and biological processes, scientists have proposed the use of hierarchical architectures (i.e., assembly of structural components) spanning several length scales from nanometer to centimeter sizes. Depending each time on the desired properties of the composite material, optimization with respect to its stiffness, weight, density, toughness and other properties is carried out. In the present subject, the interest is in magneto-mechanical coupling and tailored instabilities. Hierarchical materials, such as magnetorheological elastomers (MREs) which combine magnetic particles (at the scale of nanometers and micrometers) embedded in a soft polymeric non-magnetic matrix, give rise to a coupled magneto-mechanical response at the macroscopic (order of millimeters and centimeters) scale when they are subjected to combined magneto-mechanical external stimuli. These composite materials can deform at very large strains due to the presence of the soft polymeric matrix without fracturing. From an unconventional point of view, a remarkable property of these materials is that while they can become unstable by combined magneto-mechanical loading, their response is well controlled in the post-instability regime. This, in turn, allows us to try to operate these materials in this critically stable region, similar to most biological systems. These instabilities can lead to extreme responses such as wrinkles (for haptic applications), actively controlled stiffness (for cell-growth) and acoustic properties with only marginal changes in the externally applied magnetic fields. Unlike the current modeling of hierarchical composites, MREs require the development of novel experimental techniques and advanced coupled nonlinear magneto-mechanical models in order to tailor the desired macroscopic instability response at finite strains.

Keywords: multi physics modeling,magneto mechanical coupling
Uncovering Protein Mechanics in Physiology and Disease (ProtMechanics-Live)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Protein mechanics is a key contributor to the form and function of biological systems by mechanisms that are just starting to be unraveled. An ensuing hypothesis is that alteration of protein mechanics can trigger disease, particularly in mechanical conditions such as cardiomyopathies in which primordial underlying molecular mechanisms remain elusive. Although tempting, this possibility has not been tested due to the absence of methods that can modulate the mechanics of proteins in vivo. My proposal aims to overcome technical barriers to scientific progress by establishing manipulation of protein mechanics in living cells and animals as a new research field. In aim 1, we will address current technological limitations through the generation of genetic, protein-engineering-based mechanical loss- and gain-of-function models to interfere acutely and reversibly with protein mechanics in living systems (mLOF and mGOF, respectively). We will apply these first-of-their-kind tools to the giant protein titin, a major contributor to the force-generating and sensing properties of cardiomyocytes with strong links with heart disease, and a workhorse protein that has been instrumental in the past to understand the biophysics of polypeptides under force. In aim 2, we will exploit cellular mLOF and mGOF to define how perturbations of titin mechanics result in altered cardiomyocyte force generation, mechanosensing, mechanotransduction, differentiation and proliferation. Leveraging on our cell studies, in aim 3 we will use murine mLOF and mGOF to shed light into the contribution of titin mechanics to the onset and progression of genetic and acquired cardiomyopathy. ProtMechanics-Live builds on our unique expertise in protein mechanics and engineering, biophysics, biochemistry and cardiovascular biology to enable investigation of mechanical proteins in their functionally relevant, physiological context

Keywords: mechanobiology,sarcomere,cardiomyocyte,cardiomyopathy
Controlling Electric Signals with Insulating Antiferromagnets and Insulating Ferromagnets (INSULATRONICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Norway
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-12-01
End date: 2020-11-30
Duration (months): 60.0
Total project cost (EUR): 2140502.5
EU funding (EUR): 2140502.5
Participants: 1
Project status: CLOSED

The proposal aims to facilitate a revolution of information and communication technologies by controlling electric signals with antiferromagnetic insulators and ferromagnetic insulators. We recently discovered that antiferromagnets can be active components in spintronics devices despite their lack of a macroscopic magnetic moment, and even when they are insulating. Conventional electronics- and spintronics-based logic and memory devices, interconnects, and microwave oscillators are based on (spin-polarized) charge transport, which inherently dissipates power due to ohmic losses. The research proposed seeks to determine the extents to which “Insulatronics” has the potential to control the electric and thermal signal generation, transmission, and detection in more power-efficient ways. Insulatronics is profoundly different because there are no moving charges involved so the power reduction is significant. We hope to establish the extents to which spin-waves and coherent magnons in antiferromagnetic insulators and ferromagnetic insulators can be strongly coupled to electric and thermal currents in adjacent conductors and utilize this coupling to control electric signals. The coupling will be facilitated by spin-transfer torques and spin-pumping – a technique we pioneered – as well as spin-orbit torques and its reciprocal process of charge-pumping. The core of this project focuses on the theoretical and fundamental challenges facing Insulatronics. Beyond the duration of the project, if we are successful, the use of spin signals in insulators with extremely low power dissipation may enable superior low-power technologies such as oscillators, logic devices, interconnects, non-volatile random access memories, and perhaps even quantum information processing.

Keywords: physics and astronomy classification scheme pacs 75 76 j,72 25 b,75 70 tj,85 75 d,50 ee,76 50 g,75 30 ds,75 70 i,75 78 n,75 60 jk
European Lexicographic Infrastructure (ELEXIS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Ireland,Italy,Austria,Estonia,Israel,Bulgaria,Hungary,Slovenia,Serbia,Czechia,Netherlands,Denmark,Portugal
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2017-1-two-stage, 2017)
Start date: 2018-02-01
End date: 2022-07-31
Duration (months): 54.0
Total project cost (EUR): 4999967.5
EU funding (EUR): 4999967.5
Participants: 19
Project status: CLOSED

The project proposes to integrate, extend and harmonise national and regional efforts in the field of lexicography, both modern and historical, with the goal of creating a sustainable infrastructure which will (1) enable efficient access to high quality lexical data in the digital age, and (2) bridge the gap between more advanced and lesser-resourced scholarly communities working on lexicographic resources. The need for such an infrastructure has clearly emerged out of the lexicographic community within the European Network of e-Lexicography COST Action which will end in 2017. Current lexicographic resources, both modern and historical, have different levels of structuring and are not equally suitable for application in other fields, e.g. Natural Language Processing. The project will develop strategies, tools and standards for extracting, structuring and linking lexicographic resources to unlock their full potential for Linked Open Data and the Semantic Web, as well as in the context of digital humanities. The project will help researchers create, access, share, link, analyse, and interpret heterogeneous lexicographic data across national borders, paving the way for ambitious, transnational, data-driven advancements in the field, while significantly reducing a duplication of effort across disciplinary boundaries. ELEXIS will be carried out by a balanced consortium with distributed geographical origins. It is composed of content-holding institutions and researchers with complementary backgrounds - lexicography, digital humanities, language technology and standardisation - a crucial feature required to address the multi-disciplinary objectives of the project. In cooperation with CLARIN and DARIAH, it will focus on defining and providing common interoperability standards, workflows, conceptual models and data services as well as training and education activities focusing on user needs and cross-disciplinary fertilisations.

Keywords: lexicography,computational linguistics,artificial intelligence,linked open data,semantic web,lesser resourced languages
Functional in vivo analysis of cholangiocarcinoma development, progression and metastasis. (CholangioConcept)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1998898.0
EU funding (EUR): 1998898.0
Participants: 1
Project status: CLOSED

Genetic heterogeneity and complexity are hallmarks of metastatic solid tumors and therapy resistance inevitably develops upon treatment with cytotoxic drugs or molecular targeted therapies. Cholangiocarcinoma (CCC, or bile duct cancer) represents the second most frequent primary liver tumor and has emerged as a health problem with sharply increasing incidence rates, in particular of intrahepatic CCC (ICC). The reason for increased CCC incidence remains unclear, but influences of western lifestyle and a resulting altered hepatic metabolism have been discussed. Surgical resection represents the only curative option for the treatment of CCC, however, many tumors are irresectable at the time of diagnosis. CCC represents a highly aggressive and metastatic tumor type and currently no effective systemic therapy regimen exists. The overall molecular mechanisms driving CCC formation and progression remain poorly characterized and it thus becomes clear that a detailed molecular characterization of cholangiocarcinogenesis and the identification of robust therapeutic targets for CCC treatment are urgently needed. Taking advantage of our strong expertises in chimaeric (mosaic) liver cancer mouse models and stable in vivo shRNA technology, we here propose a comprehensive and innovative approach to i) dissect molecular mechanisms of cholangiocarcinogenesis, with a particular emphasis on Kras driven ICC development from adult hepatocytes and oncogenomic profiling of ICC metastasis, ii) to employ direct in vivo shRNA screening to functionally identify new therapeutic targets for CCC treatment and iii) to characterize the role of the gut microbiome for CCC progression and metastasis. We envision this ERC-funded project will yield important new insights into the molecular mechanisms of CCC development, progression and metastasis. As our work comprises direct and functional strategies to identify new vulnerabilities in CCC, the obtained data harbor a very high translational potential.
Optical imaging of ocular pathology in Alzheimer’s disease (OPTIMALZ)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Austria
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1497000.0
EU funding (EUR): 1497000.0
Participants: 1
Project status: CLOSED

Novel diagnostic techniques and disease models have the powerful potential to provide new insights into pathological and pathophysiological processes. Ocular manifestations of Alzheimer’s disease (AD) emerge as novel and attractive alternative to investigate disease progression in parallel to the brain. Using the eye as a window to the brain, we propose to develop multi-functional optical coherence tomography (OCT) as a noninvasive in-vivo technique for preclinical imaging of AD pathology. OCT is analogous to ultrasound B-mode imaging, using light rather than acoustical waves, and performs high-resolution real time 3D imaging of microstructure in biological tissues in situ. Based on the optical polarization properties or movement of particles, functional OCT methods provide additional contrast channels. In the proposed project, we will unite/join standard and functional OCT for imaging ocular and cerebral pathology in AD mouse models with threefold contrast. Structural changes caused by neuronal cell loss in the retina will be assessed longitudinally and with micron-scale resolution. Beta-amyloid plaques are birefringent and are deposited in both brain and retina in AD. We propose to exploit these intrinsic polarization properties for noninvasive detection and longitudinal characterization/assessment of retinal plaque load. Simultaneously, we will assess AD-related changes in retinal microvasculature. Retinal blood flow will be measured in quantitative units and monitored during disease progression. In addition to the retina, we will perform longitudinal imaging of AD-related lesions in the ocular lens with OCT. By correlating ocular AD pathology as imaged with OCT to cerebral lesions, the proposed research provides a new set of in vivo parameters that potentially shed new light on the pathogenesis and impact early diagnosis of AD in aging populations worldwide.

Keywords: optical coherence tomography,optical imaging,alzheimer s disease,mouse,retina,lens
Advanced Face Recognition and CroWd Behavior Analysis for Next GeneRation VidEo Surveillance (AWARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TERRORIST THREAT has increased in Europe and worldwide since Paris attacks in 2016. High density crowded places, such as critical infrastructures and public open areas, are being particularly targeted by those who instill terror. Both public and private sectors need next generation face recognition systems able to cover such large, crowded and unconstrained environments, and to massively process faces with high performance; altogether with the detection abnormal crowd behaviors such as mass panic, stampedes or bottlenecks. However, computational requirements and highly-priced hardware are hampering these deployments. Also the analysis of faces and crowds arises increasing concerns about privacy, and it is necessary to ensure compliance with the EU General Data Protection Regulation (GDPR) and other local regulations. We will bring an easy-to-install and user-friendly solution, covering cybersecurity needs and market replication. The AWARE PROJECT provides a disruptive solution to solve major pains: (1) First solution able to analyze crowd behavior. (2) Use of an edge computing architecture and Deep Neural Network accelerators to achieve outstanding processing speed and cost-efficiency. (3) Ensuring data privacy and GDPR accomplishment. AWARE is at TRL6, while HERTA is well-positioned worldwide as one of the few face recognition providers in crowded and unconstrained environments. The global face recognition MARKET is becoming very competitive, and expected to increase to USD 7,76 Billion by 2022 at a CAGR of 13,8%, The team involved in the project has over 25 years of experience in the innovation and commercialization of biometrics. COMPETITORS: FaceFirst (USA) and NEC (Japan) solutions are slower and do not provide: crowd behavior analysis, secure databases, hardware scalability and integrated with any type of camera. ACCUMULATED ADDITIONAL REVENUES OF 143 M€ and accumulated additional Profit of 67,9 M€ by the 3rd year; creating 30 new high-quality employments.

Keywords: facial recognition,crowd behavior
Photocatalytic Materials for Cartridge and Microchannel Flow Reactors (PhoMatFlow)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-09-01
End date: 2021-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

During the research of the ERC-funded project UNBICAT (ERC-CoG, contract number 647550), the Principal Investigator, and his research group have developed new photocatalysts and their application in different organic transformations. A recent development of the project has been the preparation of new photocatalysts and their immobilization onto different materials, making them heterogeneous catalysts. These heterogeneous photocatalysts are able to produce chemicals and products of interest to the chemical industry. Therefore, the heterogeneous photocatalysts developed in this project are expected to become valuable tools for the production of chemicals under more sustainable and milder conditions. The aim of the present Proof of Concept (PoC) project is to study their implementation in cartridges and microchannel reactors for flow chemistry. For this purpose, reaction optimization to scale-up the current mg-scale synthesis of the heterogeneous photocatalysts, and their incorporation onto cartridges and microchannel reactors will be carried out. In addition, the photocatalytic performance of the devices in the preparation of chemicals and products of interest to the industry will be validated using flow chemistry. This PoC project will also contain an analysis of the intellectual property and patent filing procedure required to protect the inventions within the field of synthesis and application of the catalyst. Additionally, a market analysis to identify potential industrial partners will be conducted. These photocatalytic cartridges and microchannel reactors will be valuable tools in different fields of the chemical industry for manufacturing chemicals, but also in academia for the preparation of products and to address other novel transformations.

Keywords: catalysis,heterogeneous materials,photocatalysis,chemical industry