Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Controllers and Observers Development for Fuel Cell based Generation Systems (ACOFC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-06-01
End date: 2013-05-31
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Despite current advances in PEM fuel cells based technologies, high costs, moderate reliability and reduced lifetime remain as major limitations. For this reason, together with the continuous improvement of materials and components, the incorporation of advanced control systems embodies a major technological challenge to address, in order to achieve cost reduction, performance improvement and efficiency optimization of these promising power generation systems. The outlook is clear in that that certain relevant features of PEM fuel cells based systems operation are closely related to their control. The activities proposed in this project strive for providing novel and practical responses to the actual requirement of efficiency and lifetime improvement of PEM fuel cells based generation systems. Special efforts will be focused on obtaining innovative and concrete results in the area of PEM fuel cells control oriented models, dynamic estimation of states and new operational variables and nonlinear control based on Higher Order Sliding Modes. Considerable work with new technologies of PEM fuel cells (such as high temperature and open cathode fuel cells) will be also addressed, as well as activities in the area of fuel cells integration into hybrid generation systems. All the proposed modelling, estimation and control tasks will be experimentally validated at the IRI’s Fuel Cells Laboratory.

Keywords: fuel cell technology,automation,process control,hydrogen energy systems,renewable energies,systems theory
Global Statistics of Ocean Currents (GSOC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

We exploit a very large global database of in situ current velocity, and temperature time series at fixed-positions (i.e. not drifting) to create summary statistics of ocean currents. Of principal interest are a decomposition of energy in different frequency bands, and the vertical and horizontal decorrelation length scales, and the interdependence between length scales and timescales. These in situ summary statistics will be complemented with those possible from satellite data (especially low-frequency motions of near surface currents, and their horizontal decorrelation scales.) To the extent possible, we will explore statistics of processes relevant to the mechanical energy budget of the ocean: 1) mechanical energy fluxes, especially the temporal correlation of vertical velocity and pressure believed to play an important role in the vertical transfer of kinetic energy to the abyss, 2) characterization of the bottom boundary layer and its role in dissipated mechanical energy. The summary statistics will include means for the World Ocean, different ocean basins, and estimates of statistical uncertainty and regional variability. For instance, we will estimate the cumulative distribution of fraction of total kinetic energy in the internal gravity wave frequency band, among many other summary statistics. By presenting the cumulative distribution one can find identify both the median and the variability about the median found in the World Ocean. The global summary statistics we explore are useful end products in themselves that are presently largely lacking in the oceanographic literature. They are also useful for many applications including planning new observational programmes such as satellite missions, validating ocean numerical modelling projects, and understanding physical processes and comparison with theoretical predictions. These applications are being pursued in collaboration with colleagues in the United States and Europe.

Keywords: physical sciences,oceanography,current statistics,model validation,internal gravity waves,ocean tides,current meter moorings
The Epistemic Role of Scientific Idealization (IDEALIZATIONS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Romania
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-12-15
End date: 2014-12-14
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

In the contemporary philosophy of science, attention has been increasingly paid to the role of idealization in providing objective and genuine knowledge about natural phenomena, that is, knowledge that ascertains their mind-independent reality and also helps us to understand why they occur in the way they do. The main objectives of the present project are (1) the critical evaluation of the current views about scientific idealization that attempt to account for this role, and (2) the proposal of a new position about the ways in which idealization serves objectivity and understanding in physics, a position that overcomes the shortcomings of the current views. With regard to (1), I focus on two recent influential attempts to accommodate idealization within a causal account of scientific explanation, by Michael Strevens and James Woodward, as well as on one equally recent and influential attempt, by James Ladyman and Steven French, to justify the view that objective knowledge requires that the structure of a theory be invariant. With regard to (2), I build on the work of David Hilbert in the foundations of mathematics and physics. My goal is to explain in what sense idealization may be considered capable of providing objective and genuine scientific knowledge, without revealing the causes of natural phenomena, and without adverting to the notion of structural invariance.

Keywords: humanities,philosophy of science
Role of the vasculature in neuronal migration. 'The neurovascular link' (NEUROVASCULAR LINK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2016-01-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A fascinating characteristic of the anatomy of the vascular system is that blood vessels exhibit a high similarity in their branching pattern and often a remarkable alignment to nerve fibers. This parallel wiring of the vascular and the nervous system might reflect its mutual dependence and also might indicate mutual guidance phenomena, with vessels providing the signals and the scaffold for growing nerves and nerves secreting angiogenic cues to guide developing vessels. The main goal of this project is to elucidate the molecular mechanisms by which blood vessels may lead the neurons to achieve proper positioning at the developing brain and the molecular cues that are involved in this guidance process. More precisely, we will explore the role of the vasculature on neuronal migration via the Reelin pathway. Reelin is a large, secreted glycoprotein that acts as a guidance molecule on migrating neurons to regulate their proper positioning during brain development. Reelin binds to two lipoprotein receptors, VLDLR and ApoER2, and induces the phosphorylation of the adaptor protein Dab1. Mice that lack Reelin expression (Reeler mice) exhibit severe neuropathological abnormalities. Our preliminary data identifies Reelin as an angiogenic factor and is the basis for an exciting project that aims at studying Reelin as a putative angioneurin, a novel concept of molecules that affects both neural and vascular cell processes. To explore this we will design an endothelial specific Dab1 null mice (Tie2Dab1-/-) to study the loss of function of Reelin selectively on endothelial cells and we will study the contribution of the vasculature to the nervous system defects in the reeler phenotype. This project will contribute to elucidate the molecular basis of the neurovascular link in health and disease and further contribute to the emerging research on the neurovascular development.

Keywords: reelin,neurogenesis,endothelial cell,neuron,angiogenesis,neurodegenerative diseases
Depth-Resolved Optical Nanoscopy (DR-NANO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A fluorescence microscope for the noninvasive imaging of the structure and dynamics in thick 3D systems with 3D sub-diffraction-limited resolution and at extended penetration depths would have a broad spectrum of applications in both the physical and biological sciences. Conventional fluorescence microscopy techniques, such as confocal and two-photon microscopy, lack the spatial resolution required for measurements at the nanoscale, whereas state-of-the-art 3D super-resolution optical microscopy methods offer limited penetration depth (<5 microns). In the proposed project, I aim to develop a new microscope that combines molecular photoswitches, fluorescence self-interference and light-sheet microscopy to optically section a thin layer deep in thick semitransparent samples with 3D sub-diffraction-limited resolution. I will then test it for potential physical and biological applications of single molecule detection. The first specific aim is to develop a depth-resolved self-interference photoswitching nanoscope employing novel high-throughput and sub-diffraction-limit fluorescence interferometry. The second specific aim is to map with 3D nanometer resolution the motion of photoswitchable fluorescent probes deep in soft materials. This study will open up new possibilities for precise measurements of the heterogeneity and mechanical properties of the nanoenvironments of soft matter at extended depths and may ultimately assist in developing superior biomaterials and nanomedical therapeutics. The third specific aim is to in situ image with 3D nanometer resolution the muscle thick filament system in fixed Caenorhabditis elegans nematodes at both the ventral and dorsal ends (separated by ~80 microns). This demonstration, if successful, will provide unique 3D super-resolution in situ image data and may assist in developing imaging protocols for in situ nanoscopy of structural changes of the C. elegans body-wall muscle system due to sarcomeric muscle diseases.

Keywords: microscopy,fluorescence,nano-imaging
Optimal Design and Operation of Microbial Ecosystems for Bioenergy Production and Waste Treatment (DOP-ECOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Many microbial ecosystems, as part of their normal activity, have the potential to provide services to society and improve environmental quality. Some can degrade contaminants that pollute water, air or soil. Others can transform waste materials into valuable renewable resources, including bioenergy, biomaterials and high-value products. This generic capability opens the possibility for combining several microbial ecosystems in integrated bioprocesses or biorefineries, where various types of bioenergy or biomaterials are produced and multiple sources of pollution are treated, all at the same time. The focus in the DOP-ECOS project is on bioprocesses that couple a photobioreactor, where microalgae capture sunlight to produce new biomass and lipids, and an anaerobic digester, where bacteria convert biomass into biogas and recover nutrients. The general objective is twofold: (i) optimize the design, operation and control of integrated microalgal/bacterial processes; and (ii) develop the supporting methods and tools for their reliable analysis and optimization. While experimental research and demonstration programs are carried out worldwide to identify suitable algae strains and expand algal biofuel production from a craft to a major industrial process, the DOP-ECOS project is the first of its kind to apply a systematic, model-based methodology in order to determine optimal design and operation strategies. The need to account for operational issues at an early design stage is particularly pressing for integrated microalgal/bacterial systems, where the operation is expected to have a profound influence on the process design, due to the intricacy of the biological and physical processes involved. Because of the large uncertainty and variability inherent to microbial ecosystems, optimization under uncertainty provides a systematic framework to design and operation these processes.

Keywords: process engineering,process control,operations research,biofuels,anaerobic fermentation
Numerical Methods for Nonlocal Problems (NUMERICS4NLP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-12
End date: 2015-09-11
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

We propose to develop scalable solvers for integral equation based nonlocal (NL) problems such as peridynamics (PD). Heterogeneity will also be studied due to utmost importance of composite materials to numerous applications in material science and structural mechanics. Robustness of the solvers with respect to heterogeneity and multiscale finite element discretizations are the subsequent directions to pursue. Since the impact of nonlocality on solvers has never been studied before, this research initiative is unique, transformative, and has great potential to create a solver subfield: nonlocal domain decomposition methods (DDM). We propose to study both the algorithmic and theoretical aspects of DDM. The solver research has the potential to reveal multiscale implications associated to NL modeling. We recently proved fundamental conditioning results indicating that the weak formulation of PD can be bounded independently of the mesh size, meaning that one can increase the resolution without increasing the condition number. Scalable and robust solver technologies will create a great impact on simulation capabilities of nonlocal problems at large. In particular, PD will be used for more complex and realistic NL applications because scalable solvers will directly impact the modeling and simulation capability. There is also imminent need for robust preconditioning in the computational material science community as composite materials become industry standard. For instance, Airbus heavily uses light weight composite materials in modern aircrafts.

Keywords: numerical analysis,computational models
New remote sensing technologies for optimizing herbicide applications in weed-crop systems (TOAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Agricultural production requires the use of herbicides as an essential tool to control weed infestations. Associated environmental and economic concerns have led to the creation of European policy that encourages farmers to optimize their use. These components are part of the agronomical basis of site-specific weed management (SSWM), whose efficient development somehow relies on the use of remote sensing technology for collecting and processing spatial data from sensors mounted in satellite or aerial platforms. Some limitations of this technology have been traditionally attributed to insufficient imagery resolution for mapping weed seedlings in early stages, just when the herbicide application is needed. Nowadays, these problems could be overcame by utilizing the new generation of remote platforms known as unmanned aerial vehicles (UAV), which can operate at low altitudes and, thus, capture images at the spatial resolution needed. This project involves the testing and applications of the UAV technology for effective weed management (or SSWM), mainly accomplished in two different crop systems: 1) Annual crops (i.e., sunflower, maize or tomato) and permanent woody crops (i.e., poplar or olive tree). The specific objectives will concentrate on the evaluation of the specifications (sensor type, imagery characteristics, crop-weed phenological stage) required for each type of crop and on the development of advanced algorithms for crop assessment and weed mapping using the captured remote images. The ultimate objective is to generate geo-referenced weed infestation maps for making in season site-specific herbicide treatments in early weed stages that, consequently, lead to a considerable decrease in the use of herbicide, a reduction in farm costs and an increase in agro-environmental benefits. Further, the potential and opportunities of this technology for other agricultural applications represent a new trend of evident relevance.

Keywords: unmanned aerial vehicle (uav),site-specific weed management (sswm),mediterranean crops,object-based image analysis (obia),early-stage weed map
Regulation of the Fe-S biogenesis in the face of stress: dynamics and involvement of new sRNAs (FESREG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Iron-Sulfur (Fe-S) cofactors containing proteins are key players in a plethora of biological pathways. Despite their essential roles, and because of the vulnerability of Fe/S cofactors, these proteins are not only highly prone to stress induced damage but also are internal “stress inducers” themselves as they can release free Fe2+ which produces toxic radicals by reacting with oxygen. Cells have thus designed multiple intricate ways to maintain Fe-S proteins integrity and to avoid Fe-S proteins to become the Achilles’ heel of the cell. A major stress defense mechanism is the fine control of Fe/S biogenesis under stress conditions. Remarkably, the model bacterium E. coli has the two most conserved Fe-S biogenesis systems, Isc and Suf that share biochemical features, yet differ under many structural and genetic aspects. E. coli thus constitutes an ideal model for the study of Fe-S biogenesis. The main focus of my project is to understand the mechanisms underlying the control of Fe-S biogenesis under stress in E. coli. To do so, this project takes advantage of technological advances to look at the dynamics of Fe-S biogenesis in the face of stress conditions. In addition, preliminary data I gathered during my post-doctoral training strongly suggest that the ensemble of Fe-S biogenesis system is regulated by small regulatory RNAs (sRNAs). In the last decade, sRNAs have emerged as major players in the control of gene expression in all kingdoms of life. Thus, an important part of this project will be devoted to identifying and characterizing the sRNAs regulating Fe-S biogenesis in response to stress. This discovery is unprecedented and could lead to a major breakthrough. The project presented herein thus constitutes an innovative and ambitious study that sits at the crossroad of two domains of investigation, Fe-S biogenesis in vivo and sRNA regulation, of utmost importance. A main objective of this project is to enable me to create my own group in the next five years.

Keywords: microbiology,rna regulation,fe-s biogenesis,genetics,fluorescence microscopy
Chromatin Dynamics In Genome Integrity (CHRODIGI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

I have developed a research program that focuses on the role of chromatin in epigenetic inheritance and genome integrity. I am pursuing three lines of research both in the model organism S.cerevisiae and in human cells: First, I am exploring the role of chromatin regulatory factors in eukaryotic DNA replication. S phase is a precarious phase in the cell cycle and chromosome stability and subsequent cell proliferation depend heavily on the accurate execution of the DNA replication process. Therefore it is of major importance to understand the chromatin-mediated mechanisms that are essential for the maintenance of genome integrity during S phase. Second, I am investigating the mechanisms that control the propagation of the epigenetic information on chromatin. The epigenetic information as defined by chromatin structures influences the state and fate of the cell. My goal is to shed light on the mechanisms that control the proliferation of specialized chromatin structures during S phase. Third, I am investigating the effect of chromatin remodeling factors in aneuploidy in yeast and human cells. Aneuploidy is a hallmark for cancer and promotes tumorigenesis. My goal is to understand the role of chromatin remodeling factors in coordinating chromatin dynamics with cell separation, thus preventing aneuploidy and genetic instability. Focusing my studies on two model factors, the histone variant H2A.Z and the multifaceted ATP-dependent chromatin remodeling complex INO80, and combining high-throughput technology with the power of yeast genetics and the imaging capabilities of human cells, I plan to uncover novel pathways that are essential for genome stability and propagation of epigenetic information.

Keywords: epigenetics,genome stability,chromatin,genomics,dna replication,cytokinesis,s.cerevisiae,human cell imaging