Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
TwinOps and vehicle specific Digital Twin for Software Defined EVs (TWIN-LOOP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Spain,Greece,France,Germany,Sweden,Slovenia,Italy,Türkiye
Call: Advanced digital development tools to accelerate the development of software defined vehicles that enable zero-emission mobility (2ZERO Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 4999502.5
EU funding (EUR): 4999502.5
Participants: 13
Project status: SIGNED

TWIN-LOOP builds on a new opportunity on computational capacity of clouds and vehicles due to the implementation of High-Performance Computing combined with digitisation of EVs under the SDV architecture. State of the art Digital Twin is still far from the complex reality of EVs core performance, somehow too naive. Besides, a given vehicle in all its variants, together with its HW and SW versions, is unique and depends on the actual use and status in terms of health and use of each specific critical components. By considering unicity of a single vehicle and learning from the operational data of a series of vehicles (fleet) and the use of data and digital models across all EV’s lifecycle in an agile and continuous manner, it would be possible to unlock the necessary extra step to reduce energy consumption without compromising comfort and safety, in fact enhancing EV driver experience, safety and cybersecurity. The TWIN-LOOP will develop an Open Framework for TwinOps for EVs along with a suite of digital tools aimed at continuously improving Energy Consumption, Hardware Costs, Driver Experience and Vehicle Resiliency across the four stages of vehicle lifecycle. The project will implement the Open Framework, integrate with EV specific tools and assess their effectiveness in realistic conditions across three different use cases, identified for their relevance to the topic. The initiative will also focus on fostering synergies between various sectors and stakeholders, aligning with European priorities and strategic partnerships like 2ZERO and Chips JU. This alignment ensures the transferability of expected outcomes and underscores TWIN-LOOP’s commitment to innovation management, research ambition, and market acceptance within the automotive industry.

Keywords: digital twin ai driver thermal powertrain model physical data operation devops agile
Introducing the Pulse Permissions Protocol, designed to place trust in data and ethics into AI (Permissions Protocol)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 12.0
Total project cost (EUR): 1607500.0
EU funding (EUR): 1607500.0
Participants: 1
Project status: SIGNED

Smarter Contracts is transforming the future of data privacy with the Pulse Permissions Protocol®, a groundbreaking solution that turns data permissions into smart data, enabling businesses to seamlessly capture, store, and automate any type of data permission, including time-bound, delegated, and multi-party consents. As businesses struggle with outdated systems like spreadsheets and CRMs, Pulse offers a decentralised, immutable infrastructure built on blockchain, ensuring trust, transparency, and efficiency in data sharing. With Pulse, permissions become a new layer of smart data, allowing businesses to streamline operations, enhance customer trust, and unlock the full potential of their data. Unlike traditional systems that introduce friction, Pulse eliminates inefficiencies by providing real-time visibility and granular control over data permissions across networks. We have already achieved Technology Readiness Level 5 and secured 18 software patents, making Pulse the only protocol capable of offering privacy-centric control at scale. However, the blockchain backend requires significant improvements to increase cost-efficiency and scalability. To overcome these challenges, we seek €1,607,500 in grant funding to optimize Pulse’s blockchain infrastructure, enhancing its transaction throughput, reducing costs, and ensuring Pulse is ready to meet the growing demands of the open data economy. This investment will fuel the development of a scalable, decentralised data governance solution that transforms how businesses and consumers engage with their data.

Keywords: open data,smart data,data protection,decentralised permissions management,customer control,real time risk management
Fragmented data, LOst voices and The potential Silences of the digitised Archive: The case of early modern Maritime disability. (FLOTSAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

The digital technologies that shape our present also shape our past. Rapid advances in archival digitisation promise unprecedented access to manuscripts exposing histories of ordinary people across archives at a global scale. However, the way we digitally store, retrieve and analyse historical data can marginalise vital intersectional histories of gender, race, sexuality and disability- casting them adrift as digital flotsam on currents of algorithmic or terminological biases and our under-theorised use of computational methods. Transformative studies of race and gender have shown how we can begin to undo this bias, e.g. redesigning machine learning tools to capture people rendered nameless by the violence of the colonial archive. FLOTSAM’s core aim is to further integrate methods for recovering hidden histories with the digital methods and interoperable systems transforming the humanities and cultural heritage, balancing and raising our awareness of power inequalities and marginalisation in our use of digital technologies. It uses eighteenth-century seafaring disability, impairment and difference to: 1) interrogate the roots and action of intersecting biases –global mobility, gender, class, work and abled-ness– inscribed in the original records and imposed externally by digital tools for data organisation, retrieval and analysis, alongside, 2) developing a method to ethically model historical knowledge as interoperable data without imposing pre-existing or new problematic systems of categorisation on marginalised people. As part of DigitalHistory@Lund and the Lund Assembly for Universal and Global History, I gain critical training in computational methods, produce vital Use Cases and an annotated corpus of maritime impairment/difference, developing my new interdisciplinary method for digital hidden histories with specialists in interpreting subaltern experiences across disparate international sources sensitive to archival power structures and marginalised voices.

Keywords: disability history digital humanities maritime history
Brain Correlates of Socially Interactive Language Learning (BraSILL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-03-31
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 3
Project status: CLOSED

More and more Europeans acquire a second language (L2) during adulthood. However, people greatly differ in their learning success across different learning settings, such as phone apps or in-class. Due to its key role in acquiring our first language during childhood, social interaction might also play an important and underappreciated role in L2 learning. Nevertheless, understanding the role and underlying processes of social interaction in L2 learning has been hindered so far by an enormous technical hurdle: natural social settings have to be translated into the controlled lab environment. With this project, we aim to use a novel approach, combining social cognition, neurolinguistics and ecological valid virtual reality (VR) to tackle this hurdle for the first time. We will design VR environments in which we can control the type of social interaction and the social agent with whom the participant interacts. This will allow us to determine all relevant factors of social interaction that benefit L2 learning success in a natural, yet controlled setting. Furthermore, we will overcome the challenge of combining the VR experience with simultaneous brain measures in the form of electroencephalography (EEG), as well as psychophysical (pupilometry and eye movements) and behavioral measures. This will enable us to measure the effects of social interaction on different cognitive levels and with different temporal resolutions. Our team associates renowned experts in neurolinguistics, L2 learning, social cognition and VR to ensure this project’s success. Furthermore, we will collaborate with a tech company to translate our results to a marketable product, targeted at immigrants who wish to acquire Catalan and Spanish. In sum, our project combines multiple disciplines and state-of-the-art techniques such as VR and EEG to finally gain insight into what is likely one of the most important drivers of language learning: social interaction.

Keywords: eeg virtual reality second language learning
PREVENTING AND DELAYING THE DEVELOPMENT OF DIABETES IN AFRICA: A RANDOMISED PLACEBO -CONTROLLED DOUBLE-BLIND PHASE III TRIAL OF METFORMIN IN HIV-INFECTED PERSONS WITH PRE-DIABETES (The META Trial)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Spain,United Kingdom,Tanzania, United Republic of,Sweden,Ireland
Call: Funding to successfully finalise EDCTP2-funded clinical trials that were negatively impacted by the COVID-19 pandemic (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 1811067.5
EU funding (EUR): 1811067.5
Participants: 7
Project status: SIGNED

Diabetes is a common co-morbidity among people living with HIV. Since Oct 2021, we have been conducting a phase III randomised placebo-controlled trial of metformin among people living with HIV and pre-diabetes in Dar es Salaam, Tanzania (EDCTP RIA2018CO-2513). The aim is to test whether metformin can prevent progression to diabetes among people living with HIV. The primary endpoint is the time to diabetes. We had planned to enrol 2100 participants, follow-up for 3 years, and finish at the end of Dec 2024. COVID-19 resulted in severe delays to regulatory review. HIV care was decentralised away from health facilities to community posts to reduce COVID-19 risk, which led to much slower recruitment. We have now enrolled 1550 participants over the last 20 months. Less than 1% have been lost to follow-up. We will reach our target recruitment in Dec 2023 and will continue follow-up until Dec 2025. This will provide an average follow-up of 3 years per participant. Analyses of aggregated data to date show that glucose levels and weight have fallen over first 12 months among the trial cohort. Thus, we believe that trial will answer the research question by continuing follow-up until Dec 2025. In 2026, we will disseminate the findings to stakeholders and to the international bodies. We are collecting clinical, health economics, and qualitative data. The trial is being done as an equitable partnership between European and African researchers, and in partnership with Ministry of Health policy-makers and African patient representative bodies. We have good links with the African Centres for Disease Control, World Health Organisation (WHO-AFRO and Geneva offices), and Global Fund in order to inform policy considerations. Merck Pharma has provided medicinal products including the placebo.

Keywords: people living with hiv,pre diabetes,metformin
When Biotechnology Meets Chemistry: Metabolic and Chemical Stable Isotope Labelling of RNA Building Blocks for the Modular Synthesis of (2H/13C/15N)-N1-Methylpseudouridine (m1Ψ) compounds (SI-MEPSI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 248353.37
EU funding (EUR): 173847.36
Participants: 2
Project status: CLOSED

The development of processes for the utilisation of renewable resources is one of the main challenges of our society. Autotrophic fermentations, in which CO2 is converted into biomass, constitute a strategy towards sustainable carbon-cycle economy. In its cutting-edge research project, SI-MEPSI will combine biotechnological and chemical approaches to create an efficient route from CO2 fixation to the production of fine chemicals. In the first stage, SI-MEPSI will optimise H2/O2/CO2-based autotrophic fermentations with Ralstonia eutropha to develop an industrial production of stable-isotope-labelled (SI-labelled) RNA under non-explosive conditions. To achieve this objective, a thorough investigation into the dependence of the growth rate on physicochemical parameters, particularly the pressure, will be performed. Subsequently, the obtained SI-labelled RNA products will be employed as building blocks in a three-step, chemo-enzymatic synthesis of novel SI(2H/13C/15N)-labelled N1-methylpseudouridine (m1Ψ) compounds – important targets in the context of RNA stability studies and NMR structural analysis. Preparation of SI-labelled m1Ψ compounds with a range of site-specific isotopic patterns will rely on a modular methodology that introduces SI-labels into the target molecules at three different points. To maximise the efficiency of the research and facilitate knowledge transfer, the fermentation studies will take place at a biotechnology company in Germany, while the chemo-enzymatic synthesis will be carried out at a university in Austria. In addition, a dedicated training program within an already existing EU ITN will further increase the visibility of the applicant and reinforce his career prospects in the EU. Through targeted dissemination activities, SI-MEPSI will also enhance the competitiveness of sustainable industrial autotrophic processes in the European Biotechnology sector, create new job opportunities, and inspire young students to pursue a scientific career.

Keywords: stable isotopic labelling,gas fermentation,chemo enzymatic synthesis,rna production,ralstonia eutropha,carbon dioxide,n1 methylpseudouridine
Performance Precision Annotator (PPA): AI-Assisted Annotation and Analysis of Music Performance (PPA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2024-07-31
Duration (months): 13.0
Total project cost (EUR): 99450.52
EU funding (EUR): 99450.52
Participants: 1
Project status: CLOSED

In the internet era, vast troves of sound recordings and musical scores have become available to virtually anyone, but drawing connections between these two mediums to develop insights about performance style and artistic expression has remained a difficult and time-consuming task. Currently, music scholars rely on general--purpose sound editing tools for annotating musical elements in recordings (such as downbeats, pitch, or note onsets); however, these annotations often must be entered manually, and these tools do not incorporate one vital element needed for analyzing recordings: musical score information. This approach can be labor intensive and inefficient, and limits the scope of the data that can be analyzed. To help address this need, we seek this fellowship to develop PPA, a prototype open--source software tool for annotating and analyzing recorded music performances, bringing innovations from the interdisciplinary Music Information Retrieval (MIR) community to scholars and musicians in the humanities. Provided with a (digital) musical score and a performance of that score, the software will automatically generate meaningful AI--driven annotations about (e.g.) note onsets, dynamics, articulations, or tempo, fully integrated with the score. With an easy--to--use graphical user interface, the software will display and visualize the score, the audio, and the selected annotations in intuitive ways designed to streamline performance analysis. Besides developing the prototype, we propose to conduct use-case studies, gathering evidence to illuminate ways PPA can be used to assist musicology scholarship, and to inform future development of the software.

Keywords: digital humanities,data science,music informatics,performance science
Characterizing the chromatin landscape of Spinal Muscular Atrophy in response to AAV9 mediated gene therapy (EpiAAVTherapy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

Spinal muscular atrophy (SMA) is a fatal neurodegenerative disorder in children, characterized by motor neuron loss and atrophy of muscle. However, SMA affects many organ systems, since the causal gene, SMN1, is expressed in all cells. Recently, an AAV9-mediated gene therapy, Zolgensma, was approved. However, challenges remain. To be effective, the systemically delivered AAV9- SMN1 needs to mimic the native regulation of the genomic SMN1. In fact, recent findings demonstrated that delivery of AAV-SMN1 under the control of the ubiquitous viral promoter CMV found in Zolgensma eventually caused death of neurons in a mouse model of SMA. To date, there has been no systematic categorization of how treatment with SMN1 is regulated in different tissues through development. Furthermore, little is understood about the chromatin changes that occur during SMA, how gene therapy impacts the long-term stability of patient’s epigenomes, or how the AAV-delivered DNA is epigenetically controlled over time. The goal of the proposed work is to understand how the epigenome reacts to gene therapy, using SMA as a model. To do so I will: i) profile the epigenetic changes during SMA disease progression in mice, before and after gene therapy, ii) evaluate the role of various promoter-enhancer structures in the vector on the epigenetic regulation of AAV-delivered episomal DNA and iii) test if endogenous promoter-enhancer combinations can be used to achieved a better tuning of the delivered gene. The proposed project combines the expertise of Dr. Piera Smeriglio in SMA models, neuromuscular disorders and gene therapy with my expertise in epigenetic profiling, gene regulation, functional genomics, and single-cell technologies. AAV gene therapies are poised to have a huge impact on rare diseases, a key priority of the Horizon Europe programme, making now a critical time to understand their effect on the epigenome and cell regulatory networks to increase the efficacy and safety of their use.

Keywords: chromatin,neuromuscular pathology,spinal muscular atrophy,smn1
CO-benefits and Risks of Enhanced Silicate weathering in agriculture (CORES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

CO2 is a potent greenhouse gas and the primary cause of global climate change (GCC). Among others, GCC induces extreme weather events, producing an extensive impact on natural and agricultural systems. Climate change mitigation requires an urgent decrease in CO2 emissions together with active CO2 removal from the atmosphere. Enhanced silicate weathering (ESW) is a promising negative emission technology for CO2 removal but requires further research. ESW accelerates the natural process of weathering-based silicate to carbonate transformation, by increasing the surface area of silicate rocks. During the weathering process, CO2 is sequestered. Agricultural fields are ideal for ESW, due to ease of access, equipment availability and infrastructural capacity. In an agricultural setting, this application can be further beneficial as the silicate rocks like basalt contains elements that promote plant growth and soil health. In addition, GCC endangers crop production by inducing drought and salinity. Approximately 75% of the cropland is subjected to drought-related yield loss while salinity affects around 50-80% of global croplands. Moreover, impacts of drought and salinity are anticipated to rise in the future due to GCC. The negative effects of drought and salinity can be countered by ESW through (i) the preservation of crop yield and quality by the silicon (Si) mediated drought and salt stress tolerance in plants and (ii) the protection of soil microbiota by the stabilization of soil chemistry. Although ESW could contribute to climate change adaptation in agriculture, these promising co-benefits were never assessed, and further research is needed to evaluate this potential in different agricultural settings. In project CORES, I aim to examine the potential of ESW, with silicate mineral basalt, for the protection of yield and quality of major crop maize and associated soil microbiota under drought and saline conditions and establish the groundwork for future field trials.

Keywords: carbon sequestration,negative emission technology,climate change adaptation,plant and soil protection under stress conditions,enhanced silicate weathering