Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nonequilibrium quantum fluctuations in superconducting devices (NEQUFLUX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-03
End date: 2016-03-02
Duration (months): 24.0
Total project cost (EUR): 249242.8
EU funding (EUR): 249242.8
Participants: 1
Project status: CLOSED

In the last fifteen years we have witnessed to an impetuous advancement in the theory of nonequilibrium fluctuations, triggered by the discovery of a number of relations, collectively known as Fluctuation Theorems, which link the full nonlinear response to equilibrium thermodynamic properties. Experimental investigations of these exact relations in the quantum regime is yet in its infancy, while we are currently witnessing a growing interest into these relations by the experimental condensed matter and quantum information communities. In an effort to stay at the forefront of new developments, this project aims at proposing feasible experiments where quantum fluctuation relations can be verified and applied. This will be achieved by pursuing two objectives, the first concerns the verification of fluctuation relations, the second their application. In both cases we will focus on experimental set-ups involving solid state superconducting devices. These are very promising tools for the development of future quantum technologies. Our first objective is to develop concrete and feasible proposals for circuit QED experiments aimed at measuring the work statistics and verifying the fluctuation relations in the quantum domain. Our second objective is to use fluctuation relations as a tool for improving the thermodynamic efficiency of solid state devices. In particular we will focus on a device, the Cooper pair pump, which hold a promise for geometric quantum computation.

Keywords: quantum fluctuation relations,nonequilibrium thermodynamics,circuit qed,cooper pair pump,berry phase
FGF-regulated miRNAs and their roles in skin inflammation and cancer (FGFMIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 199317.6
EU funding (EUR): 199317.6
Participants: 1
Project status: CLOSED

Skin cancers are the most common types of cancer in the caucasian population, and their incidence has reached epidemic proportions. In addition to skin cancer, inflammatory skin diseases are also extremely common. For the development of novel therapies for skin diseases it is essential to unravel the mechanisms that regulate skin homeostasis and pathological alterations. Recently, the host laboratory made the surprising observation that fibroblast growth factor receptor (FGFR) signalling has a tumor-suppressive function in the epidermis, since loss of FGFR1 and FGFR2 in mouse keratinocytes resulted in the development of skin inflammation, followed by spontaneous formation of carcinomas. The goal of the proposed project is to unravel the mechanisms underlying the functions of FGFRs in the epidermis with a particular focus on micro-RNAs (miRNAs). These small RNAs are emerging as new key players in the regulation of cancer-associated pathways in various tissues. However, FGF-regulated miRNAs in the skin remain to be characterized. FGF-regulated miRNAs and their targets will be identified starting from a combination of miRNA and mRNA profiling of RNA samples from epidermis of control and FGFR mutant mice at different stages of postnatal development and of tumors. Preliminary bioinformatic analysis already identified 5 miRNAs that show significant differences in expression between mutant and control mice. Accordingly, the expression level of more than 300 mRNAs was altered. Based on these data, we will identify those miRNAs that are expressed in keratinocytes in an FGF-dependent manner and we will characterize their functions and the relevant targets in cultured keratinocytes and in normal, inflamed and tumorigenic skin in vivo. Since miRNAs have already been proven to be valuable targets for the treatment of many human diseases, the proposed project has the potential to identify new possible targets for the therapy of major human skin diseases.

Keywords: fgf receptors,micro-rnas,skin cancer,inflammation,aging
The Dynamics of Independence and Interdependence in Chinese Children's Development (IIDEV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The aim of the proposed project is to study Chinese children's developmental trajectories in the context of drastic sociodemographic change. The objective is twofold: 1) to produce new empirical knowledge about the childrearing practices and cultural theories of child development in China, which can provide a basis for further cross-cultural and longitudinal comparisons; and 2) to contribute to recent multidisciplinary efforts to theorise the relationship between child development, cultural systems and social change, and to develop mixed-method approaches for research in this field. I will focus on the psychological concepts independence and interdependence that cover various values and behaviours in different sociocultural contexts, such as autonomy, collectivism, self-regulation, responsibility, competition, assertiveness and obedience. I will study the manifestation of these different components, and the way they are structured in relation to each other, in two urban Chinese communities: one of permanent urban residents and one of recent rural-urban labour migrants. The two communities differ in several sociodemographic characteristics that relate to the learning environments of infants and young children, and thus set up diverging developmental trajectories. This study of within-culture variance will allow the testing of recent theoretical formulations about the relationship between sociodemographic characteristics, cultural values and child development. It also responds to the recent calls for more cooperation and integration between anthropology and psychology. Ethnographic fieldwork will be complemented by methods of developmental psychology to address particular aspects of cognitive and social development. The aim is to conduct research that meets anthropological requirements for holism and ecological validity, as well as psychological requirements for systematicity and replicability.

Keywords: anthropology,developmental psychology,sociocultural transformation,child-rearing practices,culture and cognition
Biomass-derived Microporous Carbon Adsorbents for CO2 Capture and Storage (BIOADSORB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

This Marie Curie proposal, BIOADSORB aims the development of new and low cost biomass-derived carbon adsorbents for CO2 capture using the following strategies: (i) a new synthetic route based on hydrothermal carbonization (HTC) process and in situ salt templating for the efficient conversion of waste biomass into functional porous carbon materials (HTCs) for CO2 capture (ii) a theoretical approach based on molecular simulations and density functional theory to model and understand the HTC structure along with the adsorption and transport behavior of CO2 and other gases in those structures. (iii) An in-silico method to demonstrate the potential of HTCs for CO2 capture from real industrial streams in a cyclic separation process. The proposed synthetic path will bring new horizons to the production of biomass-derived microporous carbon materials. The theoretical studies will demonstrate the potential of the as-synthesized materials for CO2 capture from industrial streams in a cyclic separation process. The theoretical studies will also advance the understanding of the mechanism of surface-gas interactions, gas adsorption and transport behaviour inside the complex pore matrix.

Keywords: co2 capture and storage,hydrothermal carbonisation,biomass,functioal materials,salt templating,porous materials,molecular simulation,density functional theory,cyclic sepration process
Prospective Memory in Mild Cognitive Impairment (PMINMCI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-01
End date: 2016-03-31
Duration (months): 18.0
Total project cost (EUR): 231926.4
EU funding (EUR): 231926.4
Participants: 1
Project status: CLOSED

Population in Europe is ageing rapidly. Consequently, there is an urgent need to find ways to help the growing population of older people to live independent lives and preserve well being into old age. To address this pressing issue, PMinMCI will conduct the first systematic and innovative investigation of prospective memory in older adults at risk of Alzheimer’s disease. Prospective memory refers to remembering to do things in future (e.g., remembering to take medication or pay bills on time). Although it is a vitally important skill for one to function independently in everyday life, it has received so far little attention. The project will focus on: 1) identifying the prospective memory deficits that could serve as an early marker of cognitive decline and a predictor of dementia, 2) recognizing everyday memory problems of individuals in the transitional state between normal ageing and Alzheimer’s disease, and 3) proposing early psychological intervention aimed at reducing their anxiety and worry about memory. The expected results will allow practitioners to recognize opportunities for early intervention and help older adults in at-risk population maintain well being and independence in their everyday life as long as possible. The aims and expected outcomes of PMinMC perfectly fit the current and forthcoming research and innovation policy of the European Union. The project will also allow the Fellow to widen the scope of research conducted so far to include abnormal ageing and novel technology for conducting naturalistic studies with portable electronic (smartphone) eDiaries. It will also develop her ability to publish in top international journals, and establish a network of collaborators for future large-scale externally funded European and international research projects. Acquiring these competencies is crucial for attaining two major goals in her academic career: getting a professorship and becoming a top internationally recognized researcher.

Keywords: ageing,abnormal cognitive ageing,alzheimer's disease,mild cognitive impairment,prospective memory,everyday memory failures,involuntary autobiographical memories,smartphone diaries
DOT1L in Osteoarthritis (DOTOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

The DOTOS project will study the role of DOT1L in synovial joint development, homeostasis and disease with specific attention towards osteoarthritis (OA), one of the most common chronic diseases. We identified an association between the DOT1L (DOT1-like histone H3 methyltransferase) gene and OA. Histone methylation is a regulator of gene transcription. Some histone methylations result in increased gene expression, e.g. lysine methylation at lysine 79 in histone 3 (H3K79). DOT1L is the only known H3K79 methyltransferase. We demonstrated that DOT1L plays an important role in the canonical Wnt signaling cascade in a molecular complex involving TCF transcription factors. These observations stimulated us to now investigate the role of DOT1l in joint development and disease, processes associated with Wnt signaling. The key hypothesis for this project states that DOT1L and Wnt signalling are required for joint development and homeostasis but that their increased activation in progressive OA is detrimental to the joint. This project will teach us how DOT1L interacts with Wnts and other signalling pathways in joint biology and disease. In addition, we aim to develop a basis for future therapeutic approaches. Dr. Monteagudo, the candidate for the fellowship, will be trained in animal models and in translational research hypotheses. She will benefit from complementary skills training and interactions with industry to gain further maturity and independence as a researcher. This additional training will be beneficial to her career as well as to the European Research Area as there is a great societal need for translational researcher in the field of chronic joint diseases able to make links between basic biology and clinical questions. The project pays specific attention to cross-sectorial interactions and communication with the scientific community as well as with the primary stakeholders for osteoarthritis: the patients and population at risk.

Keywords: osteoarthritis - cartilage - dot1l - wnt - synovial joint
SYNTHETIC NITRENE CHEMISTRY: NEW REACTIONS AND APPLICATION (SYNIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The paramount importance of nitrogen in life and material sciences makes the search for new C-N bond forming reactions a topic of utmost interest that lies at the heart of organic synthesis and medicinal chemistry. This is a highly competitive domain, and, with the advent of organometallic catalysis, there have been numerous breakthroughs. This proposal resides at the forefront of this field, with the aim to enhance the synthetic understanding of nitrenes and to unveil new methods for the synthesis of nitrogen-containing bioactive molecules. Nitrenes, which are the aza-analogs of carbenes, are useful two-electron oxidants that offer unique synthetic opportunities for the selective functionalization of hydrocarbons, according to click-type reactions. Recently, the synthetic viability of this powerful reagent has considerably expanded, which has led to the development of catalytic C-H amination and alkene aziridination. However, despite these significant achievements, the scope of catalytic nitrene transfers remains mainly confined to these two reactions, and, thus, limited when compared to the chemistry of carbenes. The objectives for this project, which are based on consistent preliminary results reported by the host, include three main concepts. The first involves uncovering new rhodium-catalyzed alkene diamination and carboamination reactions with nitrenes, and, then, developing an asymmetric version for the diamination through the design of chiral rhodium complexes. The second part strategically applies the intramolecular diamination of indoles to synthesize naturally occurring dimeric indole alkaloids. Finally, the cytotoxic properties of the synthesized compounds will be evaluated on site at the ICSN, which could ultimately lead to the discovery of new antitumoral products. This work will be multidisciplinary, involving innovation in methodological advancements in organic chemistry, asymmetric organometallic catalysis, total synthesis and medicinal chemistry.

Keywords: nitrene,c-n bond,alkene difunctionalization,diamination,carboamination,indole alkaloid,rhodium catalysis,asymmetric catalysis,total synthesis,iodine oxidant,cytotoxic compounds
ASAMBA: AsteroSeismic Approach Towards Understanding Massive Blue SupergiAnts (ASAMBA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 177000.0
EU funding (EUR): 177000.0
Participants: 1
Project status: CLOSED

The recent space-born missions dedicated to studying stellar variability providing unprecedented high-precision photometry of variable massive Additionally, we have also monitored a sample of oscillating blue supergiants in high-precision spectroscopy over 7 years. Such rich observational data call for carefully designed methods for astrophysical interpretation. This project aims to develop and provide such methodology. Our tools will be used to enhance the understanding of the physics of massive B-type dwarfs and BA-type supergiants.

Keywords: stellar astrophysics,asteroseismology,massive stars,rotational mixing,overshoot mixing
Zinc Interaction with Phosphorus in Root Uptake (ZIPRU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The overall goal of this project is to understand phosphorus (P) and zinc (Zn) interactions in the mineral nutrition of Brassica oleracea, a species that has been bred into a wide range of crops such as broccoli, cabbage, kale and cauliflower. To achieve this, we will develop a comprehensive understanding of key mechanisms and coordination of P-Zn cross-talk that allows high P-use-efficiency (PUE) plus high Zn accumulation and thereby provide the basis for breeding programmes combining improved PUE and increased shoot Zn concentrations. Selected B. oleracea genotypes with extreme PUE and shoot Zn concentrations identified recently by the host lab and collaborators will be studied stepwise using a multidisciplinary approach including state of the art methods. Firstly, the genotypes will be characterised phenotypically, specifically for yield, root architecture traits and bulk mineral element concentrations. Secondly, root exudates will be characterised biochemically initially using Fourier Transformation Infrared for general overview followed by Liquid Chromatography-Mass Spectrometer for detailed analysis. Thirdly, tissue-specific localization of mineral elements, specifically P and Zn, will be determined using multielemental and quantitative imaging technique micro-Proton-Induced X-Ray Emission. Fourthly, gene expression profiles will be studied using the Brassica Exon Array. The anticipated results will be used to promote sustainable agriculture, through a reduction in fertiliser inputs and to improve dietary mineral intakes by increasing the mineral content of edible crops. Breeding varieties with greater PUE, without having a significant negative impact on shoot Zn content, is one strategy to simultaneously reduce the use of P fertilizers and combat dietary Zn deficiencies. Through the execution of the research, the skills acquired, and the collaborative network developed, the candidate will gain means essential to follow an independent scientific career.

Keywords: mineral interactions,root architecture traits,root exudation,element localisation,transcriptome changes,brassica oleracea
Geo-Spatial Modelling Informing Policy (GEOSINPO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-08-01
End date: 2017-07-31
Duration (months): 36.0
Total project cost (EUR): 364476.9
EU funding (EUR): 364476.9
Participants: 1
Project status: CLOSED

The aim of this fellowship is for the applicant – Dr. Harutyun Shahumyan – to move from University College Dublin (UCD) in Ireland to University of Maryland (UMD) in US for two years and then return and build on his research at UCD for another year, for the purposes of enhancing his training in integrated modelling supporting smart and sustainable growth; and to provide complementary skills training that will assist the applicant in his career path in academia. The research training will be achieved through a project dedicated to emerging techniques centred on the development of Spatial Decision Support Systems (SDSS) and application of state of the art geospatial analytical tools, which are uniquely available within the scientific resource bases of the host institutions. This project will be delivered through practical application of different integrated modelling approaches in two study regions (1) Chesapeake Bay Watershed (CBW) in US during outgoing phase and (2) Greater Dublin Region (GDR) in Ireland during return phase. Strengths and weaknesses of each approach will be explored thoroughly; and the ways of complimenting each other will be suggested taking into consideration policy makers’ needs. The applicant has a remarkable academic track record with an Honour MS degree in Applied Mathematics, a PhD in Engineering followed by 8 years of Post-Doctoral research in statistical and spatial modelling. The applicant has co-authored 15 journal articles, 2 book chapters, 7 conference papers, 4 working papers and 5 research reports and has given poster and oral presentations at 17 international conferences. The outgoing host the National Center for Smart Growth Research and Education at UMD is one of the most prominent interdisciplinary centres of smart growth analysis and modelling with extensive practise in applications supporting policy makers. It has an excellent track record of training experienced researchers and engaging them with scientists & decision makers.

Keywords: land use,model,transport,water quality,spatial,gis,scenario,policy,decision making,urban,regional development,planning,sdss,integration