Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Non-coding RNAs in neurodegeneration (NCRNANEURO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 214800.0
EU funding (EUR): 214800.0
Participants: 1
Project status: CLOSED

Large non-coding RNAs and microRNAs are important regulators of gene expression that may control both physiological and pathological processes such as neurodegenerative disorders. Given the complexity of neurodegenerative disorders, studying the role of non-coding RNAs would be necessary to understand the molecular mechanisms underlying ageing related neurodegeneration. Of particular interest, microRNAs (miRNAs) seem to participate directly in the regulation of Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) related genes. In this regard, microRNA research would be promising for the understanding of the very prevalent and poorly understood sporadic forms of AD and possibly PD. To address the role of specific microRNAs in biological models, the project will consist in determining whether down-regulation of specific microRNAs in zebrafish and mouse models recapitulate neurodegeneration. The identification of mRNA targets of such microRNAs will provide insight into the cellular pathways that are disturbed after microRNA knock-down. To complement the study on microRNAs, another objective of the project will be to determine whether large non-coding RNAs are dysregulated in neurodegenerative diseases similar to what is observed for microRNAs. The study of non-coding RNAs will provide a novel layer of complexity in neuronal cell biology and be exciting tools to probe and discover molecular mechanisms underlying neurodegeneration.
Establishment of a novel CML model using Multi-Hit technology (CMLMULTIHIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-05-17
End date: 2012-05-16
Duration (months): 24.0
Total project cost (EUR): 170981.2
EU funding (EUR): 170981.2
Participants: 1
Project status: CLOSED

The chronic phase of chronic myeloid leukaemia (CML) is characterized by the expression of the chimeric BCR-ABL gene, extended survival, and profligate growth of maturing granulocyte stemline. It provided the rationale for producing first imatinib and then a series of small molecules designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein, all of which can induce complete cytogenetic remissions in the majority of patients with CML in the chronic phase (CP). Selective inhibition of the BCR-ABL tyrosine kinase by imatinib is a promising new therapeutic strategy in patients with CML. Despite significant haematologic and cytogenetic responses, resistance occurs, particularly in patients with advanced disease, accelerated phase and blast crisis. The mechanism by which the transition from chronic to accelerated phase (AP) or blast crisis (BC) occurs remains poorly understood. The AP and BC phase of CML are usually manifested by additionally acquired oncogene aberrations, resistance to therapy, advancing anaplasia, progressive organomegaly, and increased blast count. Abnormal expression of some proto-oncogenes may accompany or even precede AP or BC of CML. Therefore, it is a critical issue to identify the molecule(s) which is (are) involved in the transition from CP to BC. To better understand such a complex clinical course of human CML, the generation of animal models that closely resemble the situation in people is indispensable. Our objective is to reveal the in vivo pathogenesis of CML with advanced phase using a novel mouse model. Moreover, an indispensable molecule for CML transition can be expected to be found in our study, which might be exploited for both prognostic indicators as well as new targets for therapy.

Keywords: genetically modified organisms,chronic myelogenous leukaemia,blast crisis
Micro-textured Surfaces for Boundary Layer Control (MTSBLC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-10-04
End date: 2012-10-03
Duration (months): 24.0
Total project cost (EUR): 172240.8
EU funding (EUR): 172240.8
Participants: 1
Project status: CLOSED

The purpose of the proposed research is to investigate the mechanics of micro-textured surfaces, often referred to as “self- cleaning coatings”, and their influence on the incompressible fluid boundary layer as it undergoes transition from laminar to turbulent flow. Our approach combines Direct Numerical Simulation (DNS) and experimental studies, and will provide a theoretical framework for the use of micro-textured coatings in passive boundary layer control. This has broad applications in fluid mechanics from drag reduction to heat transfer enhancement to turbulent transition control. Control of these characteristics has an important role in a broad range of technologies where fluid interactions occur such as sea and air transport, power generation, electronics cooling, and microfluidic devices. Microfluidics, in particular, has been described as an enabling technology for a broad range of interdisciplinary applications including biological and chemical processes. Surface geometries that provide properties such as laminar stability which will delay the transition to turbulence, reduce turbulent shear stress and reduce drag are of great importance for improving efficiency, hence reducing operating costs and environmental impact. The research will comprise of a detailed analysis of the effects of geometries such as arrays of micro pillars and ribs on boundary layer slip and wetting at the wall. These findings will then be used to generate effective boundary conditions which take into account the dynamics of the underlying slip surface for large scale simulations of the complete transition process. This will illustrate how coating a surface with these features can be best used to influence characteristics desired in particular flow regimes. Using the knowledge gleamed from the simulations, experiments will be performed to demonstrate the efficacy of the coatings and the validity of the boundary conditions at the wall.

Keywords: fluid mechanics,two-phase flow,direct numerical simulation,particle image velocimetry,micro-texturing,computational physics,flow instabilitiy,transition to turbulence,energy saving,drag reduction
Emission Comb Spectroscopy: Development of novel frequency comb spectroscopy methods based on stimulated Raman scattering (EMCOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 166535.2
EU funding (EUR): 166535.2
Participants: 2
Project status: CLOSED

Coherent control of ultrafast lasers results in well-defined frequency combs revolutionizing many aspects in fundamental and applied science. Most recently, frequency comb technology was used to push the performance of Fourier transform spectroscopy to unprecedented levels. Multi-heterodyne spectroscopy is a rapidly growing research field opening new perspectives in terms of sensitivity, spectral resolution and data acquisition time which has been demonstrated in various experiments on absorption spectroscopy. Here, we propose a novel technique for frequency comb based precision spectroscopy based on stimulated Raman scattering. This approach or emission frequency comb spectroscopy in general has not been addressed so far. We describe two schemes for measuring the Raman response of molecular samples and the corresponding proof-of-principle experiments. Based on the pump probe technique, the consequences of the excitation of rotational transitions in molecular hydrogen will be measured by multi-heterodyning with phase-locked frequency combs. The first technique relies on Raman induced Stokes gain and anti-Stokes loss, respectively, experienced by the probe pulse whereas the second is based on the time dependent measurement of the transient index perturbation. As multi-heterodyne spectroscopy is capable to yield the full complex spectrum, both schemes can be studied with a similar setup. Another goal of this proposal is the design of a tailored fibre based dual frequency comb system to be able to fully exploit the potential of this spectroscopic technique. The advances of our scheme will then be utilized for spatially resolved spectroscopy and microscopy which is particularly useful for biological samples. Broadband measurement allows simultaneous analysis of various transitions. The proposed project constitutes a new direction for nonlinear precision spectroscopy with a huge potential for many branches of science and interdisciplinary research.

Keywords: spectroscopy,microscopy,experimental physics,applied optics,molecular physics
Somatosensory signals and the “I” of conscious experience in healthy subjects and neurological patients (SELF-CONSCIOUSNESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-04-01
End date: 2012-03-31
Duration (months): 24.0
Total project cost (EUR): 172565.2
EU funding (EUR): 172565.2
Participants: 1
Project status: CLOSED

The present project will address key questions on how the representation of the body by the brain contributes to the sense of self. I will intend to study the contribution of somatosensory inputs to bodily self-consciousness in healthy subjects and polyneuropathic patients. Virtual reality and cognitive science in combination with muscle tendon vibrations and brain imaging techniques (high density electroencephalography (EEG)) will be used to reach this goal. I propose to investigate this in the context of the recently described “full body illusion” that uses visuo-tactile conflicts to alter crucial aspects of bodily self-consciousness such as “what we feel as our body” (self identification) and “where we experience our body to be” (self-location). The “full body illusion” will be associated with vibrations applied at the lower limbs in order to determine whether bodily self-consciousness is altered by such somatosensory noise in healthy subjects. The vibration technique reproduces to some extent the degradation of proprioceptive inputs that is generally linked with polyneuropathy. In order to further understand the contribution of the somatosensory system to bodily self-consciousness I also plan to carry out the above described experiments in polyneuropathic patients. This proposal is highly original in its combination of high-quality quantitative psychophysical and neuroimaging studies of fundamental body perception with deep neuroscientific and philosophical questions about the neural basis of the self. This research will be of great relevance not just for science, but also for diagnostics in neurology and psychiatry, neurorehabilitation of polyneuropathic patients, virtual reality applications and man-machine interfaces. Finally, the neuroscience of self-consciousness is also of great interest for the general public. The topic of self-consciousness has not only been a mystery for scientists, but naturally intrigues most humans.

Keywords: health sciences,neuropsychology,bodily self-consciousness,eeg,polyneuropathy,virtual reality,somatosensory information,muscle tendon vibration,cross-modal congruency effect
Knowledge Transfer and Innovations in European Cross Border Regions (KTIECBR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-10-15
End date: 2012-10-14
Duration (months): 24.0
Total project cost (EUR): 169888.0
EU funding (EUR): 169888.0
Participants: 1
Project status: CLOSED

Cross-border regional cooperation in education, human welfare , migration, environmental conservation, and tourism has been recently established in the form of supranational alliances supported by EU funding, aimed at decreasing the political barriers created by boundaries and increasing regional competitiveness, European cohesion and economic prosperity for peripheral areas across the union. This collaboration is particularly successful amongst SMTEs and includes marketing, joint promotion, and training programmes for owners and employees. While these and processes of regionalization have been studied, knowledge transfer and diffusion of innovations amongst SMTEs and the contribution of the unique characteristics of cross-border regions to these processes have been ignored. Since border regions host people from different countries, cultures and backgrounds, they may as well be considered a ‘melting pot’ for creativity and innovations hosting that makes than an innovative milieu for the tourism industry. The study will identify knowledge transfer and innovative processes amongst SMTEs in cross-border regions in the context of EU funded initiatives, such as INTERREG, between Finland, Sweden and Norway and the aspects influencing their nature. It questions whether proximity to border intersection influences the levels of innovations and creativity and whether intensive movement of people and tourists influence the transfer of ideas and diffusion of innovations. The study will also identify indicators for monitoring levels of creativity and innovations in these areas and whether cross-border business networks are used as knowledge transfer mechanisms. In-depth interviews with SMTEs owners/manager, tourism officers and programme leaders, will take place in both regions as well as some quantitative data regarding the exchange of products and levels of revenues from the introduction of new tourism facilities and products will be compared.

Keywords: social sciences,economics,cross-border region,tourism innovations,interreg,humanities
Investigation of mathematical models for thin-film flows (TFE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-10-01
End date: 2012-09-30
Duration (months): 24.0
Total project cost (EUR): 172903.2
EU funding (EUR): 172903.2
Participants: 1
Project status: CLOSED

This research project will bring together Dr Roman Taranets, an outstanding young researcher at the Ukrainian National Academy of Sciences, and Professor John King, a leading expert in the theory of thin film flows at Nottingham University, UK. The research will be focussed on flows of thin liquid and polymer films. The combination of Dr Taranets’ background in research methods for the rigorous investigation of the qualitative properties of solutions to nonlinear partial differential equations and the host’s expertise in formal asymptotic methods and contacts with a range of industry-driven applications will be an ideal basis for a successful fellowship. During the research project, we will • study exact asymptotic behaviour travelling wave solutions for the thin film equation with non-zero contact angles; • show the existence of a generalized solution for multi-dimensional coating flow models without surfactant and to investigate the behaviour of support of these solutions; • investigate the asymptotic behaviour of generalized solutions for multi-dimensional coating flows with surfactant; • put in place additional research programmes involving novel areas of application and employing innovative combinations of mathematical techniques. Benefits of this transfer of knowledge will include the implementation of the collaborative research programmes above, the initial training of both early-career researchers in the UK and Dr Taranets in complementary mathematical approaches and the application of these unusual combinations of skills to a host of applications that are representative of the many fields in which high-order parabolic systems are now playing a central role. Moreover, ongoing collaborations between the Ukrainian and UK groups will provide a conduit for the continued expansion of the scope of these research activities. The ERA will benefit from proposed fellowship due to access to new approaches and methods for studying nonlinear PDEs.

Keywords: natural sciences,differential equations
Recognition of viral DNA by the innate immune system (DNA RECOGNITION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-01-01
End date: 2011-12-31
Duration (months): 24.0
Total project cost (EUR): 217241.0
EU funding (EUR): 217241.0
Participants: 1
Project status: CLOSED

Herpes simplex virus 1 and 2 (HSV1/2) are important human pathogens, causing both acute and recurrent infections leading to serious diseases such as encephalitis, herpes keratitis, genital herpes, and potentially fatal disseminated disease in newborns. Pathogen recognition by the innate immune system is mediated via host-encoded pattern recognition receptors, which recognize conserved pathogen-associated molecular patterns (PAMPs) and trigger the production of pro-inflammatory cytokines and chemokines, including the type I interferons and interleukin 1. Recent studies have demonstrated that DNA may be an important PAMP. However, very little is known about the physiological role of viral DNA recognition in the innate immune response. The proposed project will utilise state-of-the-art technology in cell biology, bioimaging and animal models to investigate the physiologic role of virally delivered DNA in immune activation, and identify and classify the pathways and receptors involved, establishing the host laboratory as a world leader in the field. The overall hypothesis of the project is that HSV infection leads to release of DNA in the cytoplasm of host cells, which recognize the DNA through specific receptors, and initiate a protective innate immune response. Specific aims: Aim 1 – Describe the role of cytosolic viral DNA in initiating the innate immune response to HSV and characterise the mechanism of DNA release from the virion into the cytosol. Aim 2 – Determine the contribution of cytosolic DNA receptors to the immune response against HSV in vivo. Results from the proposed project may aid in (i) identifying potential novel drug targets, (ii) improving vaccine efficacy, (iii) and allowing control of the potential side effects of viral gene delivery systems.

Keywords: immunology,infections
Efficient and Effective Evaluation of Information Retrieval Systems (EFIREVAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-05-01
End date: 2012-03-05
Duration (months): 22.0
Total project cost (EUR): 172240.8
EU funding (EUR): 172240.8
Participants: 1
Project status: CLOSED

Information Retrieval (IR) is a ubiquitous technology. The range of tasks and information collections IR systems are applied to is ever growing. However, the ability of researchers and developers to build high quality searching systems for new environments is not keeping up with the growth in potential application areas. As a consequence, search system quality is degrading: users of bespoke systems expect a Google-like experience of swift high quality retrieval; instead they commonly get slow sub-standard results. The key reason for this failing is the profound lack of testing resources that capture the unique and complex environments different retrieval systems are deployed in. The cost of building test resources is prohibitively expensive. Consequently, researchers are unable to assess the effectiveness of new ideas in such environments, search engine vendors struggle to tune their systems to the particular needs of their customers, customers looking to choose between competing search products do not have the resources to measure which system will better serve their needs. This project will address this problem by developing a new evaluation paradigm for search, which will, (1) establish an efficient and reliable test resource construction methodology, (2) develop a framework to adapt such resources to a wide variety of retrieval scenarios, and (3) extend the current evaluation paradigm to incorporate additional information about the different retrieval scenarios and users&apos; activities. With such a methodology, researchers will develop and test a far richer set of approaches to search; companies will provide systems better suited for customer needs; organizations will be able to test more thoroughly their existing installed systems. Ultimately, developing the new paradigm will help ensure that the standard and quality of results common to web search will be available in all searching situations.

Keywords: on-line information services,information systems,information technology