Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PROSTHETIC VALVE BIOACTIVE SURFACE COATING TO REDUCE THE PREVALENCE OF THROMBOSIS (PV-COAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 2367055.0
EU funding (EUR): 2367055.0
Participants: 2
Project status: CLOSED

Heart valve prostheses are currently among the most widely used cardiovascular devices. To maintain enduring optimal biomechanical properties, the mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation, which often leads to adverse reactions, i.e. higher risks of thromboembolism, hemorrhage, and hemolysis. Continuing advances in heart valve prosthesis design and in techniques for implantation have improved the survival length and quality of life of patients who receive these devices. In an ongoing effort to develop a more durable and biocompatible heart valve prosthesis, researchers have used a variety of techniques to determine the suitability of given valve materials for a given implant application. In recent years, advances in polymer science have given rise to new ways of improving artificial cardiovascular devices biostability and hemocompatibility. To date, no polymer coated mechanical prosthetic heart valve exists. The present research project aims to improve the hemocompatibility and long-term in vivo performance of mechanical prosthetic heart valves by reducing contact-induced thrombosis through bioactive polymer prosthetic valve surface coating. These new coated prosthetic heart valves will be designed for hemodynamic performance and durability similar to uncoated materials, combined with a greater thromboresistance, both in vitro and in animal studies. With these promising advances, bioactive surface coated prosthetic heart valves could replace previous generation of prosthetic valves in the near future. The utmost perspective of the current project paves the way for the development of new bioactive coating for other implantable cardiovascular devices or materials.

Keywords: mechanical prosthetic heart valves,coating,valve thrombogenicity
Biomolecular Identification of Ornaments (BIJOU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-30
End date: 2019-03-29
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: TERMINATED

Symbolic material culture and personal ornaments can be used as effective proxies for tracking mobility and identity in the past: prehistoric Europe was interconnected by a network of long-distance exchange routes of shell “jewellery”. The movements of ornaments can thus reveal contact between communities, elucidating cultural dynamics and patterns of migration. In the absence of written documents, reconstructing the journey of ornaments from their place of origin to their final destination requires secure information on the taxonomy and provenance of the shells. BIJOU will develop a novel interdisciplinary approach for shell ornament identification, advancing the traditional morphological methods and exploiting the biomolecules trapped in shells as taxonomic barcodes. Integrating six state-of-the-art techniques (proteomics and amino acid analyses, macro- and micro-morphology, mineralogy, stable isotopes) and focusing on fifteen key archaeological sites across Europe, BIJOU will build the first publicly available reference collection of shells, identify the materials used to make ornaments and determine their local or exotic provenance. This will provide the long-awaited scientific basis for theories on long-distance exchange in prehistory. Building on the complementary expertise of the Researcher (archaeology and ancient proteins) and the Host Institution (shell biominerals), BIJOU will deliver long-term scientific benefits, including an ad-hoc methodology for the investigation of precious artefacts, and the establishment of an international network of archaeologists. The wealth of information on the modes and tempos of interaction between peoples in the past will be the focus of public dissemination and will inform current debate on the fundamental right of freedom of movement and perceived loss of cultural identity, contributing to building a European society that is truly “inclusive, innovative and reflective” (Europe 2020 strategy).

Keywords: personal ornaments,shell,biomineralisation,mobility,identity
Training the Next Generation of European Visual Neuroscientists for the benefit of innovation in health care and high-tech industry (NextGenVis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Israel,Italy,Germany,Germany,Germany,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 3886818.12
EU funding (EUR): 3886818.12
Participants: 15
Project status: CLOSED

The human visual brain can learn and adapt to change, which solves many of the problems posed by an ever-changing visual environment. However, to maintain a consistent overall representation of the visual world, the brain also has to retain previously acquired neuronal mechanisms. The key is to strike a balance between plasticity and stability. Increasing our knowledge about the stability and plasticity of the visual brain has tremendous potential for innovation in health care and high-tech industry: 1) rehabilitation, treatments and detection of disease can be developed and refined based on knowing how the brain changes as a result of visual loss or neural dysfunction; 2) it can inspire the development and implementation of artificial intelligence, such as adaptive automated vision systems. However, our present knowledge of the adaptive capacity of the human brain is incomplete and largely qualitative in nature. This limits translation into significant applications. To overcome this, NextGenVis –Research Network for training the Next Generation of European Visual Neuroscientists – will aim its research and training efforts on teaching young researchers in how to a) acquire new, quantitative knowledge on the adaptive properties of the visual brain in health and disease – with a strong focus on the neurocomputational basis – and b) apply this new knowledge to boost innovation in health care and technology. Our pan-European team of academic, health care and private sector partners is ideally suited to accomplish this as it bundles and focuses unique European expertise and resources in brain imaging, psychology, neurology, ophthalmology and computer science. Importantly, the positive impact of this network will extend beyond the current focus on vision and will last long after the funding period. It will continue to link together a team of highly skilled researchers who will inspire each other to excel in visual neuroscience and its applications.

Keywords: human visual cortex,plasticity,learning,neuro imaging data analysis,functional magnetic resonance imaging,fmri,rehabilitation,adaptive vision systems,ophthalmology,neurology
Eco-innovation in Composites Recycling for a Resource-Efficient Circular Economy (R3FIBER)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Composite materials or FRPs are the construction materials of the future. Due to their excellent properties (light weight and high mechanical performance), FRPs are becoming the material of choice for industries such as aerospace, automotive, construction or wind energy. Market drivers such as regulations on CO2 emissions reduction or increased energy efficiency guarantee this rising trend. However, a new environmental problem is arising since no industrial process exist that allows for material recycling or valorisation. End-of-life composite materials, already considered as an emerging waste, are currently landfilled, the last disposal option in the Waste Directive. A spin-off of the Spanish Higher Council for Scientific Research (CSIC) born in 2016, Thermal Recycling of Composites S.L. (TRC) aims to industrially develop, exploit and commercialise a technology for the recycling of composite materials, allowing for complete valorisation of mass, energy and materials in a zero-residue process. The R3FIBER process, validated at pilot plant scale, provides a disruptive solution to recycle wind turbine blades and other composites, obtaining high quality glass and carbon fibres, heat and energy in a clean and energy-efficient, self-sustained process, thus creating a new global market for raw composite materials. The new process will contribute to address European priorities related to circular economy (COM/2015/0614), resource efficiency (COM(2011) 571) and low carbon economy (2050 Roadmap). During Phase 1, the technical and economic feasibility of R3FIBER will be studied to define key sectors for market introduction, establish strategic alliances with key stakeholders and design the scale-up of the industrial plant for implementation and industrial exploitation during Phase 2.

Keywords: circular economy,waste management,composites,wind turbine,recycling,fprs,resource efficiency,sustainability,raw material,waste valorisation
Multidisciplinary Institute for Ageing (MIA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Framework Partnership Agreement
Countries involved: Netherlands,United Kingdom,Portugal
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-04-29
End date: 2020-04-28
Duration (months): 60.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 5
Project status: CLOSED

This project describes a teaming partnership between the University of Coimbra (UC) (partner in a low-performing country) and the University of Newcastle (UNEW) (partner in a high-performing country) to create, in Coimbra, a new Centre of Excellence in Ageing Research - the Coimbra Multidisciplinary Institute of Ageing (MIA). This flagship project for the Centro Region of Portugal is aligned with the regional RIS3 and will be coordinated by the regional authority CCDRC (strategic coordinator) and by UC (operational coordinator). The Newcastle University Institute for Ageing (NUIA) is one of the largest and longest established institutions in translational ageing research worldwide. In this teaming project, NUIA is supported by two further world-leading centres in translational ageing research; the University Medical Center Groningen (UMCG) and the Mayo Clinic Robert and Arlene Kogod Center on Aging. European Member states are committed to increase human healthy life expectancy by two years on average by 2020. Present increases in healthy life expectancy are largely due to increasing differences in ageing rates between member states, regions, communities and individuals. This massively worsens socioeconomic inequalities. Recent progress in understanding the mechanisms of ageing suggests that social, lifestyle, nutritional and pharmaceutical interventions can, effectively, reduce these differences by targeting the faster ageing members of the population. The overall objective of the new Centre for Excellence is to improve health and wellbeing of an ageing population. It will gain a forefront position in ageing research and develop, validate and deliver interventions that can improve human healthy life expectancy. It will train young researchers and engage the public in support and implementation of innovative good practices. MIA will be integrated into the Ageing@Coimbra Vitality Campus, a European Innovation Partnership on Active and Healthy Ageing Reference Site.

Keywords: centre of excellence,ageing research,multidisciplinary,health and wellbeing,smart specialisation strategy,research and innovation,regional cluster,vitality campus
Natural nEUROactive Mechanical mETAmaterials (NEUROMETA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: India,United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2478140.0
EU funding (EUR): 2435807.5
Participants: 2
Project status: SIGNED

Metamaterials with anomalous and counter-intuitive multiphysics behaviours have been developed during the last two decades to help communication systems, sensing and robotics. Paradigmatic developments in artificial intelligence, Digital Twin approaches and additive manufacturing are pushing the design and production of metamaterials also towards the development artificial equivalent of synapsis and programmability. These advanced metamaterial concepts are however fossil-based and tend to make use of materials with a high carbon footprint and heavy life cycle costs in terms of emissions and environmental sustainability. Sensing/actuation mechanisms are also innate in natural plant fibres, spider silk strands and enzymatic systems, and involve saturation, hygromorphism, piezoelectricity and controlled hysteresis that could provide similar synaptic behaviours. Programmable memory properties could also be mechanically created in solid matter, and similar mnemonic-type architectures abound in natural fibres and related composites. While neurogenesis in electromagnetic metamaterials is at early stages of development, no neuroactive mechanical metamaterial concept and design based on biobased materials has been developed so far. The project aims at developing this paradigmatic new class of metamaterials. We will explore the use of natural fibre composites, bio-based matrices, spider silk strands, 3D printing of bioblock materials and natural piezoelectricity in wood/cellulose combined with metamaterial architectures to develop artificial bio-based and sustainable surrogates of programmable memory with learning/adaptive behaviours similar to artificial neural networks. These metamaterials will autonomously learn from their past loading history and generate resilience in the structures in which they are embedded. The natural materials will also have low carbon footprint and could be further developed by worldwide R&D communities based on the resources locally available.

Keywords: mechanical metamaterials,natural fibres,biobased materials,artificial neural networks,neuroactivity
Green battery-less Tire Pressure Monitoring System (GT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2017-05-31
Duration (months): 26.0
Total project cost (EUR): 803179.29
EU funding (EUR): 562225.5
Participants: 1
Project status: CLOSED

The main objective of the project is the growth and internationalization of FARSENS by the development of a Tire Pressure Monitoring Systems (TPMS), an electronic system in charge of the monitoring of the wheels air pressure, providing a real-time information. This information is very useful in regarding security, but also in terms of gas consumption, and thus in terms of reducing air pollution. Besides the intrinsic interest of this system in relation to security and environment, it is also mandatory by legislation to be installed in all the new cars in the USA and it will be mandatory by the end of 2014 for all new models, what makes an increment of around 50 million vehicles equipped with this system until 2015. Taking into account 4 devices per vehicle, it turns out in 200million TPMS units. This project will lead the company growth for the next years from a high technology solution developer to an important stakeholder in automotive industry. During the last years the main strategy of the company has been focused on creating a reliable structure in order to ensure the success once one of the developed products entries the market. This project is “natural” as it is the next logical step to develop its strategy. FARSENS battery less solution meets all technical specifications and minimizes costs due to: 1-Cost-effectiveness (less subcomponents and the new design makes it half the actual cost). FARSENS solution is based on a battery less system and a 99% of inclusion of the sensor’s functionalities in only one ASIC. These decreases the cost of the components and assembly cost. 2-Saving due to less waste management and easier recycling (there is not battery), without compromising the quality or the service. Thanks to the SME instrument, 2017 could be the year with the first sales, with an estimated 28% profit (0.55 M€) and during 2018 it is estimated an accumulated balance of 0.5 M€, being the ROI only 2 years.

Keywords: tpms,automotive sensors,battery free
Innovative Microalgae Feed Ingredient to improve Animal Health for a more sustainable Food Chain (MiAlFeedIngredients)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Germany,Netherlands
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Problem: Due to excessive application of antibiotics in animal feed multi-resistant bacteria stems emerge, causing thousands of human casualties each year. Globally farmers have strong financial interests to use antibiotics as a growth promoter for livestock. Kang et. al. have shown in an animal feeding trial with 600 chicken, that microalgae have the same growth promoting effect as antibiotics. But so far microalge have been too expensive for application in the animal feed industry. Solution: The consortium has developed a feed ingredient based on microalgae that can deliver these health promoting effects to animal feed with the same value for money for farmers as antibiotcs. The consortium has cut production costs for microalgae by over 50%. Farmers will switch to our product because they face no legal restrictions and meet consumer´s growing demand for sustainable meat. Customers: Customers are companies within the feed industry, who would include our product into their own recipes/products. Consumers are farmers, who face a conflict of interest between growth promotion, strict regulation of antibiotics and consumer behavior. This makes them receptive for innovative alternatives to antibiotics. Project: Having successfully manufactured samples in 2015, the feasibility study will lay the basis for a successful market introduction by confirming the business plan. We will accomplish an in-depth market research and a competitive analysis. As a result we will define the selling price of our product in relation to competing natural additives. Market: The problems of animal mass production and the incentive to use medication as a growth promoter are the same all over the world. The regulatory pressure and the demand for feed for an ever increasing global meat production is the basis for a huge market potential for our product. Example: If 1% of our product is added to all piglet diet which is sold in Europe, the estimated annual market size would be over EUR 600 mio.

Keywords: microalgae,feed ingredient,antibiotics,bioactive ingredient,animal health,feed efficency,immune,system,mycotoxin binding,antioxidants,omega 3,pigs,piglets,poultry,chicken,diary cows