Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improved coordination of national and European bioeconomy research and innovation programmes in the ERA through strengthened SCAR Working Groups (RefreSCAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Ireland,Denmark,France,Netherlands,Spain,Finland,Poland,Portugal,Serbia,Germany,Belgium,Bulgaria,Hungary,Italy
Call: Fostering strategic advice and synergies between national and EU research and innovation agendas, including SCAR foresight (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 3999952.5
EU funding (EUR): 3999952.5
Participants: 18
Project status: SIGNED

The Standing Committee on Agricultural Research (SCAR) is a long-standing committee of EU Member States and Associated Countries presided over by the European Commission. It has become a respected source of advice on European agricultural and wider bioeconomy research and has been a catalyst for the coordination of national research and innovation (R&I) programmes. It is supported in these strategic functions by SCAR Working Groups (WGs), including a Foresight Group, which provide domain-specific expert advice and input. RefreSCAR will strengthen the strategic functioning and capacities of SCAR WGs in order to facilitate the improved coordination of national and European bioeconomy R&I programmes. Through a toolkit of measures, RefreSCAR will provide robust scientific support to SCAR WGs through regular portfolio analysis of projects, expert studies and support for the SCAR Foresight process. Combined with practical administrative support, this will enable a better structured organisation, facilitation and reporting of SCAR WG activities in themes of relevance for Horizon Europe, the Common Agricultural Policy, European Green Deal, Digital Europe and the Farm to Fork and Biodiversity Strategies. In order to boost the participation of under-represented countries in SCAR WGs, a SCAR-Engage Programme will be developed involving tailored action plans, financial and peer-to-peer support, networking and knowledge exchange. Targeted support for communication and dissemination will immerse a broad audience of stakeholders in the activities of the WGs. Furthermore, RefreSCAR will cultivate connections between SCAR WGs, key actors in EU policy, practitioners and relevant EU and international initiatives through dedicated fora, helping to build a bridge between R&I, policy and practice. The outcome will be more impactful SCAR WGs that are better resourced and empowered to deliver strategic advice, contributing to a strengthened SCAR within the European Research Area.

Keywords: research,innovation,bioeconomy,food systems,aquaculture,bio based
Generating Unstable Dynamics in dispersive Hamiltonian fluids (GUnDHam)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1444033.0
EU funding (EUR): 1444033.0
Participants: 1
Project status: SIGNED

This project aims to prove rigorous results on the generation of unstable dynamics in the dispersive Hamiltonian water waves and geophysical fluid equations: I refer to the outstanding open problems of the formation of energy cascades from low to high frequencies, orbital instabilities and extreme rare phenomena such as rogue waves. All these behaviors are well documented in experiments, real world data and numerical simulations, but still lack a rigorous mathematical proof. Accordingly the project has three lines of research: 1) Energy cascades from low to high frequency modes: I plan to construct solutions of water waves and geophysical fluids equations in which energy shifts from low to high Fourier frequencies, induced by resonant interactions, provoking the growth of Sobolev norms. This will be attacked via a novel mechanism based on dispersive estimates in the frequency space, that I have pioneered in the linear setting; 2) Orbital instabilities of Stokes and Rossby waves: I plan to study the linear and nonlinear modulational instabilities of traveling solutions like the Stokes and Rossby waves in the higher dimensional setting, proving long-time conjectures in fluid dynamics and geophysics. This will be attacked by extending a program I have initiated in the one dimensional setting; 3) Extreme phenomena formation: I plan to construct rogue wave solutions of the water wave equations, confirming (or disproving) two of the most renowned physical conjectures regarding their formation. This will be achieved combining deterministic normal forms and probabilistic methods, like large deviation principles applied to PDEs. These goals aim to open new paradigms to understand the long time dynamics of dispersive Hamiltonian partial differential equations originating from fluids.

Keywords: dispersive hamiltonian fluids,energy cascades,modulational instability,rogue waves
Deciphering the role of immunoglobulin classes in shaping Follicular Lymphoma molecular heterogeneity and evolution (FolLyway2HIT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Follicular lymphoma (FL) is the second most common B cell neoplasm, characterized by the t(14;18) chromosomal translocation, resulting in deregulated BCL2 oncoprotein (BCL2tx+). In situ follicular neoplasia (ISFN) represents an early precursor lesion, histologically identified as BCL2+/CD10+ Germinal Centers (GC), that might progress into FL. Spatial and temporal genomic analysis in FL revealed that its transformation into aggressive high-grade MYC/BCL2 Double-Hit lymphoma (DHL) arises predominantly from a common precursor that clonally diverges upon the acquisition of genetic hits through iterative GC transitions. Expansion of FL B cells requires the presence of a functional B cell- receptor (BCR), which can be expressed in either unswitched (immunoglobulin M (IgM) or switched (IgG/IgA) isotype. Preliminary data from the hosting laboratory showed an isotype-dependent regulation of Ig levels in FL and MYC/BCL2 DHLs prompting the hypothesis that specific IgH classes may differentially impact pre-tumoral FL lesions, shaping the transforming trajectory of ISFN cells, overt FL cells and finally giving rise to DHL. Using state-of-the-art technologies, including single-cell and spatially-resolved transcriptomics and genetics analyses, I will define IgH-class dependent transcriptional changes in the transition from ISFN to FL and, eventually, DHL and the influence of specific isotype to shape intra and inter tumor heterogeneity and tumor mutational landscape. Finally, I propose to determine whether the immunoregulatory activity of tumor-infiltrating immune/stromal cells is influenced by the expression of defined Ig-isotypes in lymphoma cells. Overall, this action will establish previously uncharacterized roles for distinct IgH classes to determine transforming trajectories promoting the transformation of BCL2tx+ GC B cells into first FL, and later DHL, providing novel clinically relevant biomarkers predicting patient outcome and tumor evolution.

Keywords: in situ follicular neoplasia,follicular lymphoma,double hit lymphoma,spatial transcriptomics,immunoglobulin classes,b cell antigen receptor signaling
EFFICIENT COMPACT MODULAR THERMAL ENERGY STORAGE SYSTEM (ECHO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Italy,Belgium,Romania,Spain,United Kingdom,Serbia,Türkiye
Call: Thermal energy storage solutions (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 6981698.52
EU funding (EUR): 6169498.0
Participants: 20
Project status: SIGNED

The project’s goal is to develop and demonstrate novel modular, compact, high performances and Plug&Play thermal energy storage (TES) solutions for heating, cooling and hot tap water production. The new concept of TES proposed in the project will provide electricity load shifting with meaningful peak shaving of the thermal and electric load demands. Furthermore, the exploitation of renewable sources will be a key point of the new TES device considering at the same time the cost-effective results in terms of energy, costs and sustainability of the system. The project will provide a TES system able to store energy for heating and cooling in building applications for a period of at least four weeks. The novel TES system will be based on a closed-loop TCM reactor insulated by PCM and equipped with an ice storage, again integrated with PCM, for high cooling energy demand. The thermodynamic cycle has been designed to benefit from a further PCM thermal buffer tank, breaking through the closed-loop concept by compensating the energy for humidification with its latent heat. An advanced heat pump will be finally dedicated to the power conversion during the thermal charging process of reactor and PCMs storages, increasing the overall performance. A dedicated control system will be developed to operate the TES according to the energy production and the end-users’ requirements, adapting to the conditions of use according to the type of air conditioning system and the particular demand for domestic hot water. The TES solution will be adaptable to all the different possible European scenarios, in terms of energy policy and end-users’ requirements. It will be designed to be used both as integrated into the building heating system and in the smart electricity grid, or in buildings not connected to district heating and cooling network. Different characteristics of the system will be taken into account, ranging from storage efficiency and durability to cost reduction and LCA and LCCA.

Keywords: thermal storage,tcm,pcm,heat pump
Feasibility of a multi-panel of epigenetic markers of fish growth (EPISELECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Norway
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-07-01
End date: 2024-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Aquaculture, the process of controlled fish and shellfish cultivation, is a sustainable alternative to fisheries. The sector has seen tremendous growth and Nile tilapia is one of the most important commercially farmed species worldwide. To date, the optimization of production yields is limited to traditional selective breeding programs, that exclusively focus on genetic markers. As a result, unknown variability in growth selection remains, which may be diminished through epigenetic selection. Prof. Jorge Fernandes’ group has found evidence for the direct involvement of multiple categories of epigenetic markers in growth rate and size of Nile tilapia. During the ERC Consolidator project EPIFISH (#683210), Fernandes’ group observed important differences in expression levels of non-coding RNAs (ncRNAs): full-sibling groups of Nile tilapia with distinct growth rates expressed different sets of ncRNAs in muscle, despite being reared under the same environmental conditions. EPISELECT will explore the technical and commercial feasibility of a multi-panel for the assessment of epigenetic markers for fish growth optimization. This multi-panel will assess the newly discovered ncRNAs in combination with the previously identified DNA modification markers. As a result, EPISELECT may improve selective breeding programs, leading to higher profitability and increased sustainability of the aquaculture sector. To reach the proof-of-concept stage, we will: 1) Explore ncRNA markers for growth prediction and validate the multi-panel of epimarkers; 2) Define an IPR position and strategy; 3a) Assess the market size, added value, cost analysis, and commercialisation route of the novel multi-panel of epigenetic markers; 3b) Establish connections with aquaculture industry and embed the project for commercialisation.
Majorana zero mode control and detection platform (MAJOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1997500.0
EU funding (EUR): 1997500.0
Participants: 1
Project status: SIGNED

The non-abelian state of matter has not been experimentally confirmed and remains an important field of research. Its detection and manipulation are critical in order to develop a coherent quantum computer in the future. The overarching goal of this proposal is to build a working topological qbit based on the braiding of Majorana zero modes (MZMs). But there are two main challenges. The first is to create a 2D environment where such states can be adiabatically spatially exchanged, while the second is to detect the presence and the evolution of such a state. To overcome these challenges, I will combine two novel techniques that are currently not widely available: (a) the SQUID-on-tip (SOT) magnetic and thermal microscopy and (b) a platform to manipulate vortices at the nanoscale that was developed by my research group. The research will focus on the MZM, which is one of the candidates for a non-abelian state. In particular, I will consider MZMs predicted to be localized at the center of vortices or skyrmion-vortex pairs (SVP). The project has three work packages: (1) develop a novel platform for vortex and skyrmion manipulation, including the integration of a charge detector to detect the vortex charge in trivial vortices. (2) Investigate different materials and their related heterostructures that could host MZMs at the center of vortices or SVP. These materials include FeTeSe and heterostructures, such as strong spin-orbit semiconductor/superconductor, ferromagnets/superconductors. (3) Combine the results from WP1 and WP2 to detect the presence of MZMs. This includes gapless edge state and fractional vortices detection using the SOT, and charge sensing developed in WP1. This ambitious project has the potential to revolutionize quantum computing and quantum materials physics. By enabling new experiments, it will establish a new field where 2D exchange statistics can be directly controlled and observed.

Keywords: superconducting vortex,topological superconductor,squid on tip microscopy,majorana zero modes
Serotoninergic Regulation of Body Axis Morphology (SeRBoMo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-21
End date: 2025-06-20
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

Idiopatic scoliosis (IS) is a human pathology that affects 1-4% of adolescents worldwide, who suffer from spine deformities for which an effective treatment is not currently available. At present, evidence for genetic causes of IS exist, but the aetiology of this pathology is still not understood. The zebrafish is a powerful organism to model human pathologies that entail body axis misalignment as, by swimming in a viscous liquid, its spine is subject to forces similar to the ones acting on the spine in bipedal position. One essential player in the establishment of embryonic zebrafish longitudinal axis is the Reissner Fibre (RF). The RF consists of SCO-spondin protein, which, during post embryonic life, is secreted by a paraventricular organ, the SCO. Zebrafish scospondin mutants lack the RF and exhibit severe scoliotic phenotype. Remarkably, a similar scoliotic phenotype is observed in the tph2-/- zebrafish, genetically depleted of serotonin. Preliminary observations have shown that serotoninergic projections reach the SCO, in mammals and in the zebrafish. My research objective is to unravel how the neuronal activity of serotoninergic neurons can control the maintenance of a straight longitudinal body axis during the zebrafish post embryonic life. Firstly, a detailed characterisation of spine alignment in correlation to RF assembly will be carried out in the tph2-/- zebrafish. Secondly, the serotoninergic neurons projecting to the SCO will be anatomically located and mapped. Thirdly, the neuronal mechanism by which serotoninergic neurons regulate RF maintenance will be functionally investigated. The long-term goal of this research project is to gain insights in the progression of IS, and to inform preclinical research on the development of diagnostic tools, which are currently lacking.

Keywords: zebrafish,body axis morphogenesis,serotonin
Sustainable, form-stable, and fire-safe phase change materials: from structure design to real applications (SAFEPCM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: CLOSED

Phase change materials (PCMs) has attracted much attention of researchers during the past two decades. However, current PCMs still have seriously potential problems on the fire safety mainly due to the flammability of the PCM substances. In this context, fire safe PCMs offer some advantages over conventional PCMs, leading to safe PCMs become very promising candidate for advanced energy saving field; but they still have a lot of challenges. In this project, aiming at solving some key scientific problems of PCMs and providing theoretical basis to the development of new generation fire safe PCM, based on the sophisticatedly structure design and fabrication the fellow will focus on the study of advanced (Sustainable, form-stable, and fire-safe) PCMs. The main objectives include: (1) To design and realize support materials for phase change materials with low cost, biomass source, good compatibility with organic PCM substances, uniform open pores, and convenience to realize large-scale preparation; (2) To design and prepare biobased phase change materials with fire safety, high thermal conductivity, and form stability: realize adjustable phase change temperature and ultra-high phase change enthalpy; (3) Develop the practical application of this new type of high-performance PCM in solar energy harvesting and storage, energy conservation and temperature regulation abilities; and (4) To expand the application of PLA, ionic liquid, other bio-based molecules (e.g., phytic acid, tannic acid, Chitosan, and Sodium alginate) in the new generation of PCMs. This proposal presents an interdisciplinary and innovative approach with great significance. These original ideas will bring us bran-new multi-functional and sustainable PCMs. It also provides a practical technical approach for the comprehensive design of PCMs.

Keywords: energy storage,bio based,flame retardant
Real and synthetic scenarios generated for the development, training, virtual testing and validation of CCAM systems (SYNERGIES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Spain,Germany,France,Belgium,Austria,Greece,Sweden,Netherlands,Italy,United Kingdom,Croatia
Call: Generation of scenarios for development, training, virtual testing and validation of CCAM systems (CCAM Partnership) (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 18833167.6
EU funding (EUR): 18636667.6
Participants: 36
Project status: SIGNED

SYNERGIES confronts pivotal challenges within the CCAM community, such as the absence of interoperable scenario databases, time-consuming and expensive development cycles, and regulatory ambiguities. It achieves this by implementing the Safety Assurance Framework developed in HEADSTART and SUNRISE. SYNERGIES furnishes stakeholders with interoperable, federated scenario databases, incorporating data from Safety Pool Scenario Database™, ADScene, StreetWise, VV Methods, L3Pilot, Hi-Drive, and more. This facilitates standardized processes, streamlines development cycles, and ensures regulatory compliance. To accomplish this, SYNERGIES will culminate in a European platform designed to enhance the development, training, virtual testing, and validation of CCAM systems. The SYNERGIES Platform comprises a Scenario Dataspace, aligned with Europe's approach to data sharing and competitiveness, and a Marketplace, ensuring continual updates and Dataspace scalability. Furthermore, SYNERGIES encourages the inclusion of new initiatives into the scenario dataspace by offering the requisite tools and guidance, from data processing and scenario identification to scenario database governance. This presents a unique opportunity to amplify investments in research and development, consolidating Europe's leadership in CCAM development, all while prioritizing safety and data protection.

Keywords: scenarios,database,marketplace,dataspace,ccam,validation,safety