Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MANUFUTURE 2019 - Sustainable Smart Manufacturing (MF 2019)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Coordination and support actions
Countries involved: Finland,Finland
Call: Presidency event (conference) in Finland: Sustainable Smart Manufacturing (H2020-IBA-LEIT-NMBP-Finnish-Presidency-2018, 2018)
Start date: 2019-02-01
End date: 2020-01-31
Duration (months): 12.0
Total project cost (EUR): 245702.5
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

The aim of the project is to organize a conference "Manufuture 2019 - Sustainable Smart Manufacturing, MF2019" in cooperation with the Finnish government. The MF2019 conference will be part of European Days for Sustainable Circular Economy 30.9.-1.10.2019 and will be organized at the same time with The sustainable transition to a low carbon, climate-resilient circular economy: Creating the knowledge base, CE2019 and Sustainable innovation (SI). The Manufuture 2019 conference on 30 September to 1 October 2019 has been planned as a flagship event during the Presidency of the Finland of the Council of the European Union. The opening sessions on the first day of the two-day European Days for Sustainable Circular Economy will be organised parallel by the three separate conferences, while the second day programs are conference-specific, taking place at the same time and in the same venue. The second day will end to a joint adjourn, that will summarise and conclude the main findings and messages of the opening session and the three conferences, as well as draft key messages and recommendations for future actions on sustainable transitioning towards low carbon, climate-resilient circular economy in the European Union. Organising the three conferences at the same time with separate costs and is expected to bring several benefits, in particular as regards the visibility, spreading the information and invitations, management of the events, as well as the impact, networking, and sharing and dissemination of knowledge and resulting in common learning. Altogether 650 attendees are expected to the European Days for Sustainable Circular Economy as a whole and around 250 participants will be expected to attend the MF2019 conference.

Keywords: finnish presidency 2019,manufuture 2019
Chimeric antigen receptor (CAR) T-cell therapy against solid tumors by targeting the vasculature (AngioCAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-07-15
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Advances of adoptive cellular therapy and monoclonal antibodies (mAbs) have resulted in unprecedented responses in patients with malignant tumors. Due to the fact that tumor growth and metastasis depend on the formation of new blood vessels, termed angiogenesis, direct targeting of the tumor vasculature provides a universal point of engagement in the battle against cancer. The main objective of this project is the development of chimeric antigen receptor (CAR) T cell approaches to target the tumor vasculature. Although extremely effective in hematological malignancies, success of CAR T cell strategies against solid tumors is lagging behind. It is hypothesized that aiming CAR T cells towards the tumor vasculature will be effective, as (i) the target is readily accessible via the blood stream and (ii) the engineered T cells do not need to enter the immunosuppressive environment of the tumor. Vimentin, which is known as a cytoskeletal protein, was found to massively externalize from tumor endothelial cells and to become deposited in the surrounding matrix, while expression in all other cells is exclusively intracellular. Therapeutic targeting of this extracellular vimentin (eVim) with antibodies – or through vaccination – resulted in pronounced inhibition of tumor growth, in absence of toxicity. AngioCAR is a multidisciplinary project, aimed to develop CAR T cells against eVim for targeting of solid tumors. Newly developed antibodies against eVim will be expressed as the CAR to redirect T cells to the tumor vasculature. This will not only result in direct endothelial cell killing, but will also increase local inflammation and reduce immune suppression. The project also aims for testing the possible synergistic combination with checkpoint inhibitors as well. AngioCAR results have the potential capacity to open new avenues in cancer treatment in terms of enhancing specificity and efficiency.

Keywords: car t cells,vascular targeting,immunotherapy,cancer
The Entrepreneurial Laboratory for teachers’ training. A Capability Approach for Entrepreneurship Education in Vocational education (EntreLab)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 179325.6
EU funding (EUR): 179325.6
Participants: 1
Project status: CLOSED

The aim of this project is to create a model for continuous teachers’ training on entrepreneurship education, provide guidelines and best practices on the pedagogies conductive for entrepreneurship education in vocational education. The Entrepreneurial Laboratory will be composed of workshops with the participation of teachers in vocational education and the various stakeholders that will discuss how to implement entrepreneurship education in the specific vocational setting chosen for the research. The focus will be on the pedagogies teachers will establish in order to encourage, facilitate and support their students being entrepreneurial in and outside the school environment. Within Europe 2020 entrepreneurship is considered particularly important as it can tackle youth joblessness and favour social inclusion. While changing the educational system is not an easy process, steps must urgently be taken to implement short, medium, and long term agendas that a move education in the right direction to match Europe 2020 objectives. The literature on entrepreneurship education and the government documents highlight the need to improve the quality of entrepreneurship education in vocational secondary schools through a switch of the pedagogies (teaching methods and didactics) and the creation of conditions for students to show sense of initiative and entrepreneurship in and outside school.In line with a capability approach the final goal will be increasing students’ autonomy and ability to make choices. With this post doctoral research comprising scientific publications plus experience in teaching and supervising students, as well as more entrepreneurial competencies the Experienced Researcher will be ready for associate professorship.
The role of ubiquitination in stability and plasticity of the GABAergic synapse (UbiGABA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Proper brain functioning requires a balance between inhibitory and excitatory synaptic activity. This balance can be maintained by regulating the number of neurotransmitter receptors in the postsynaptic membrane. A major inhibitory synaptic receptor is the hetero-pentameric GABAA Receptor (GABAAR), which is stabilised in the synapse by the intracellular scaffolding protein gephyrin. Gephyrin, in turn, is recruited to and stabilised at the synapse by the adhesion protein neuroligin-2 (NL2). Regulation of synaptic strength involves lateral diffusion of GABAARs into and out of synapses, endocytic downregulation followed by either degradation or membrane re-insertion, and altering the size of gephyrin clusters. Altered GABAAR trafficking is implicated in neurological and psychiatric disorders, including epilepsy and excitotoxicity in ischemia. The underlying mechanisms, however, remain poorly understood. Ubiquitination is a well-known mechanism that regulates protein trafficking and turnover, however its role in stability and plasticity of the GABAergic synapse remains unclear. Preliminary work from the Kittler lab suggests that: 1) the ubiquitin ligase Unk plays a key role in ubiquitination of the GABAAR; 2) gephyrin can be poly-ubiquitinated and that its proteasomal turnover may be regulated by the de-ubiquitinating enzyme OTUD4; 3) NL2 can be mono-ubiquitinated, potentially directing its trafficking, and that the ubiquitin ligase Nedd4 may regulate this process. Thus ubiquitination may play several key roles in regulating the dynamics of receptor, scaffold, and adhesion molecules at the inhibitory synapse. Using molecular, biochemical, cell biological, and state-of-the-art imaging approaches I aim to study how ubiquitination of GABAARs, NL2 and gephyrin affects GABAAR trafficking, and formation and stability of the inhibitory synapse. This may lead to improved understanding of how ubiquitination regulates neuronal excitability in healthy and pathological conditions.

Keywords: ubiquitination,inhibitory synapse,protein trafficking,gabaa receptor,neuroligin 2,gephyrin,postsynaptic density,protein turnover,synaptic plasticity and pathology,endocytosis
Screening and development of optimized materials for high temperature coils (HTcoils)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Austria,Austria
Call: Screening and development of optimized materials (wires, potting resins and impregnating varnishes) for high temperature coils (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2021-05-31
Duration (months): 39.0
Total project cost (EUR): 685068.75
EU funding (EUR): 498095.26
Participants: 3
Project status: CLOSED

Electrical Environmental Control Systems (E-ECS) feature many low power electromechanical actuators to ensure control and tuning of items such as valves. They also include motorized turbomachines with power electrical motors. In both cases, the temperature class of coils integrated in motors or electromechanical actuators must be increased to minimize requested cooling and thus optimize both integration and mass of the system. So, these high temperature coils can be: A winding of electromagnet, a winding of a torque motor, a winding of a power electrical motor. The main objectives of this topic are: - to develop specific wires, impregnating varnishes and potting ingredients (resins) to have complete solutions for high temperature coil and qualify these ingredients, - to manufacture high temperature coils with these ingredients, integrate them in the Topic Manager’s defined application and demonstrate that the solutions proposed can be industrialized. The solutions shall comply with aeronautical constraints (electrical, vibration, lifetime, manufacturing process, etc.) and sustain a minimal temperature of 300°C. The main objectives of this topic are to develop specific wires, impregnating varnishes and potting ingredients (resins) to have complete solutions for high temperature coil and qualify these ingredients, to manufacture high temperature coils with these ingredients, integrate them in the Topic Manager’s defined application and demonstrate that the solutions proposed can be industrialized.

Keywords: high temperature coils,copper wires,innovative varnishes,impregnation and potting materials
SEaSiDE (Smart Electro-expulsive System for SAT Aircrafts De-Icing) (SEaSiDE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Austria,Italy,Italy,Netherlands,Netherlands,United Kingdom
Call: Low Power De-Icing System suitable for Small Aircrafts (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-02-01
End date: 2022-03-31
Duration (months): 62.0
Total project cost (EUR): 1700000.0
EU funding (EUR): 1190000.0
Participants: 6
Project status: CLOSED

Aviation has become an indispensable part of European transportation system, however, the system as it existstoday is reaching full capacity and beginning to limit mobility. In addition, there is a demand formore people and goods to travel faster and farther, with fewer delays” as defined by the H2050 target to complete door-to-door journey within 4 hours for 90% of travellers One solution to increasing mobility in European transportation system isto exploit the existing small community airports across Europe and to improve safety, comfort and operability (especially in all weather operation - Icing) of the small aircraft community aircrafts. Expand as much as possible the safe operation in all weather , and much more in icing conditions, of the small aircraft is one of the key point. Aircraft De-Icing System is one of the most power demanding onboard systems and for this reason small aircrafts are sometimes limited in icing operation. This is much more true if we consider that small aircraft (SAT) area affected by limited space availability for system installation and that due to the low volume of this general aviation market sometimes is not easy to find the Systems supply chain ready to afford requirements coming from SAT OEMs at a relative low cost (there is a sort of market failure). SEASIDE Project aims at solving the above issues by developing an innovative compact and low cost “Hybrid Electro-Expulsive De-Icing System” for the Piaggio P180 aircraft complying with CS23 Appendix C. Objective of SEASIDE project is to analyze, design, develop, test in an Ice Wind Tunnel Test (IWT) and deliver to the Topic Manager a prototype of Hybrid (thermal and electro-expulsive) De-Icing system having the following expected targets: • A continuous Power demand for meter on wing span of 0.6KW.

Keywords: ice protection,electro expulsive,hybrid ice protection system
Insulin resistance and Tauopathy : Insights from Drosophila models and human brain samples (AlzDiabetes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-12-19
End date: 2018-12-18
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting about 20 million people worldwide. Although aging is considered to be the most important risk factor for Alzheimer's disease, growing evidence from epidemiological studies suggest that type-2 diabetes (T2DM) increases the risk factor of AD. While compelling evidence establishes a link between insulin resistance and amyloid burden, relationships to tau are far from clear. In a recent study, it was shown that dysregulation of brain insulin signaling in both AD and T2DM, correlates to hyperphosphorylation of tau, a key abnormal tau modification leading to neurofibrillary tangles. Recent reports indicated that AD was associated with brain insulin resistance with significant abnormalities in the expression of genes and activation of kinases that are regulated by insulin and insulin-like growth factor signaling. Although a connection has been suggested between AD and diabetes, the mechanisms that link insulin resistance to AD are still unknown. Insulin resistance also leads to the impairment of autophagic pathway needed for clearance of misfolded proteins in neurodegenerative disorders. The objective of this study is to utilize robust Drosophila models of tauopathy and diabetes to decipher the underlying mechanistic pathways connecting these two devastating diseases. Furthermore, this proposal aims to study the effect of autophagy towards clearance of misfolded proteins in the background of insulin resistance and subsequent treatment of disease models with insulin sensitizing/autophagy activating drugs to ameliorate disease phenotypes. The results from this study will be further validated in post mortem brain samples from healthy and diseased patients for future therapeutic studies.

Keywords: alzheimer s disease,type 2 diabetes,glycogen synthase kinase 3 beta,extracellular regulating kinase,autophagy,mammalian target of rapamycin
Living with Radiation: The Role of the International Atomic Energy Agency in the History of Radiation Protection (HRP-IAEA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1999705.0
EU funding (EUR): 1779580.0
Participants: 2
Project status: SIGNED

This project addresses the central question of how the International Atomic Energy Agency, a diplomatic and political international organization, came to dominate scientific institutions with a long tradition in radiation protection. Despite the importance of international organizations for the development of postwar science there is no work on the history of radiation protection in relation to the development of the IAEA. The project addresses this lacuna in a groundbreaking way: it analyses what is usually treated as a strictly techno-scientific issue—how best to protect us from ionized radiation—using methods from history, philosophy, and sociology of science, and in the context of international history. The main hypothesis is that scientific knowledge about radiation protection has been shaped by diplomatic, social, economic, and political concerns. This approach casts new light on important aspects of postwar history of science, combining attention to state actors, science diplomacy, and the roles played by international organizations. Given the enormous interest in radiation protection the time is ripe for providing a comprehensive social, historical, and political study of the role of the IAEA in the field. The main objectives of the project are: • to retrace the international history of radiation protection after World War II, focusing especially on the Technical Assistance Programs of the IAEA; • to investigate the role of the IAEA in sponsoring knowledge production in the field of radiation protection in competition with other regulatory agencies; and • to analyze the standardization of instruments, objects, procedures, and technical vocabulary as the main strategy used by the IAEA for guiding radiation protection worldwide. The project advocates a "diplomatic turn": diplomacy becomes analytical category in history of science. Highly interdisciplinary it brings together expertise from several disciplines, promising a significant advancement across them.

Keywords: history of radiation protection,history of modern physical sciences,iaea,international organizations,standardization,history of nuclear sciences
SEA Applied to the Prediction of High Frequency Vibrations in Aircraft Engines (VibSEA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,Czechia
Call: Prediction of High Frequency Vibrations in Aircraft Engines (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2022-12-31
Duration (months): 45.0
Total project cost (EUR): 848459.38
EU funding (EUR): 848458.0
Participants: 3
Project status: CLOSED

Designed to achieve reduction in fuel consumption, the Ultra-High Bypass and High Propulsive Efficiency Geared Turbofan engine incorporates evolutions likely to produce high frequency (HF) vibration excitations which propagate through the structure. Numerical simulation is an efficient tool to control vibrations hence supporting the mechanical design. Where Finite Element (FE) based approaches show limitations due to computational hardware performances and HF dispersion management, Statistical Energy Analysis (SEA) stand as proven and effective method for this frequency range to predict the vibrational energy transfers across partitions – subsystems – of a structure. Challenges of SEA modelling consist of the structure partitioning which usually requires expertise and the accuracy loss at lower frequencies where the high stiffness of parts or complexity of junctions counter the method initial assumptions. Those statements depend strongly on the studied structure, therefore the objective of the proposed project is to develop and demonstrate a SEA modelling process to predict the vibration propagated in a typical complex engine frame. In this scope, best modelling practices from detailed numerical analysis are engaged to both support an extensive test campaign preparation including test vehicle design and manufacture, and produce models covering the target frequency range: from 400Hz to 10kHz. A crucial phase consists in the validation and update of these models from tests post-processing techniques and known methods such as Experimental SEA, Decay Rate damping estimation or input conductance as well as innovative inverse approaches relying on optimization loops. From the comprehensive comparison of these different methods with tests results, a best methods and associated modelling practices are delivered to the topic leader. CETIM and ESI join their complementary competences to develop the modelling and experimental know how applied to the HF vibrations assessment.

Keywords: statistical energy analysis,experimental,simulation,modelling,high frequency vibrations