Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Water Resources System Safe Operating Space in a Changing Climate and Society (SOS-WATER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Austria,Netherlands,Spain,Italy,Germany,Switzerland,Romania,Viet Nam,Norway
Call: Improved understanding, observation and monitoring of water resources availability. (HORIZON-CL6-2021-CLIMATE-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 4099406.25
EU funding (EUR): 4099405.0
Participants: 13
Project status: SIGNED

Water scarcity, water quality degradation and the loss of freshwater biodiversity are critical environmental challenges worldwide, which have primarily been driven by a significant increase in water withdrawals during the last century. In the coming decades, climate and societal changes are projected to further exacerbate these challenges in many regions around the world. As such, defining a safe operating space (SOS) for water resources in a changing climate and society is urgently needed to ensure a sufficient and reliable supply of water of a quality acceptable for human activity and natural ecosystems. However, defining the SOS for the entire water resources system at spatial scales relevant to decision-making and its projections into the future requires going beyond state-of-the-art water system modelling toward a holistic and participatory assessment framework that includes data gathering, integrated modelling, and working with relevant stakeholders. SOS-Water aims to create the foundation for this framework. It will co-create future scenarios and management pathways with stakeholders in five case studies in Europe and abroad. It will advance water system models and link them with impact models of ecosystem services and biodiversity, to create a novel integrated water modelling system. This integrated water modelling system will be benchmarked against a wide range of state-of-the-art Earth observations and will be used to calculate selected indicators covering all dimensions of water resources systems, to ultimately design a multi-dimensional SOS of policies and water management pathways evaluated across a broad set of scenarios. The results of SOS-Water will help improving the understanding of water resources availability and streamline water planning and management at local to regional levels and beyond, such that the allocation of water among societies, economies, and ecosystems will be economically efficient, socially fair, and resilient to shocks.

Keywords: water systems monitoring,earth observation,risks and vulnerabilities assessment
Deciphering the radiobiology of targeted radionuclide therapy: from subcellular to intra-tumoural analyses (RADIOBIO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1750000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: SIGNED

Background and unmet need Targeted radionuclide therapies (TRTs) are a promising modality to treat patients with metastasized cancer. TRTs function via systemic administration of radiolabelled molecules (α- and β-particle emitters) designed to target tumour cells. However, the radiobiological effects of TRTs are poorly understood, and rational design of new modalities based on underlying cellular mechanisms is therefore not possible, resulting in suboptimal treatment strategies. Since most patients with advanced cancer cannot be cured at the moment, it is therefore my ultimate goal to improve TRT. Aim My ERC project aims to identify and quantitate specific radiobiological mechanisms of TRT-radiation effects in vitro and in vivo. Objectives This unique multidisciplinary project will yield critical information on subcellular and intra-tumoural radiopharmaceutical uptake kinetics, DNA damage response kinetics and dose response simulations, and will profoundly increase our knowledge on TRT to push the field forward. I will determine cellular dosimetric parameters for α-TRT and β-TRT, determine effects of subcellular and intra-tumoural localizations of TRT on DNA damage induction and survival, image in vivo TRT efficacy and define effects of treatment heterogeneity to ultimately perform realistic dosimetric simulations in 2D and 3D cancer models. Besides using previously developed techniques, we will develop an innovative new imaging setup for high resolution imaging of TRT by intravital confocal microscopy to image real-time cellular processes of anti-cancer therapies in a living organism. Expected Outcomes Outcome of my project will not only increase our fundamental knowledge on TRT and yield a novel imaging modality, but additionally has high potential to contribute to improved treatment strategies and ultimately patient outcomes.

Keywords: targeted radionuclide therapy,radiobiology,intravital fluorescence microscopy,dosimetric simulations
Pipeline for Rapid Diagnostics of Emergency Transboundary Infectious Diseases (PREPARE-TID)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Innovation actions
Countries involved: Germany,Austria,France,Italy,Serbia,Spain,Sweden,Finland,Türkiye,Greece,Brazil,Uganda,Senegal,Bangladesh,Hungary,Switzerland
Call: Pandemic preparedness and response: In vitro diagnostic devices to tackle cross-border health threats (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6331715.0
EU funding (EUR): 5999360.0
Participants: 20
Project status: SIGNED

It has become apparent that the ease of travelling, global warming, and changes in the environment accelerate the spread of infectious diseases of zoonotic origin. International collaboration is essential to impact on the control of disease epidemics, and as the COVID pandemic has shown rapid diagnostics are one of the main pillars. PREPARE-TID will target infectious agents of three types: an ongoing neglected epidemic, an ongoing emerging epidemic, and an ongoing elimination drive. The aim is to develop the necessary in vitro diagnostic tools for preparedness needed in case of the emergence of infectious agent X. PREAPRE-TID is a multidisciplinary research consortium drawn from 16 European and 3 international research organisations and SMEs. Biomedical researchers will work alongside epidemiologists, clinicians, veterinarians, and software engineers to implement a pipeline from a mobile suitcase sequencing laboratory with a simple bioinformatics to a fieldable rapid nucleic acid extraction procedure, a mobile smartphone linked molecular point-of-care and a multiplex PCR one-health surveillance platform, and a one health digital platform. These will provide innovative diagnostic solutions for cross-border health threats at international level. PREPARE-TID will increase the accessibility to novel diagnostics for detection of pathogens with pandemic potential. The consortium will deliver point-of-care and mobile diagnostics, which can be easily deployed and mass produced in case of an epidemic or pandemic.

Keywords: infectious diseases epidemics pathogen x digital tools one health
The physical, cultural, and bio-genetic landscape of the last Neanderthals (LAST NEANDERTHALS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Italy,Israel,Germany
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-06-01
End date: 2030-05-31
Duration (months): 72.0
Total project cost (EUR): 12920328.0
EU funding (EUR): 12920328.0
Participants: 5
Project status: SIGNED

Our closest relatives, the Neanderthals, abruptly disappeared 40 thousand years ago (ka) after having endured for 350 thousand years in a territory ranging from the Iberian Peninsula to southern Siberia. Decades-long research attempted to address the cultural aspects and the demographic and environmental factors that triggered their demise. Yet, there are no widely accepted scenarios that satisfactorily explain the extinction of the Neanderthal. These shortcomings are in part because the data available originated from a limited number of sites mainly in western and central Europe, which we now know were peripheral to the range of the last Neanderthals. To compellingly reconstruct the chain of events that led to Neanderthal’s extinction, the scientific community needs new extensive archaeological data, possibly from the core regions of the last Neanderthals’ range. Areas of western and central Asia and eastern and southeastern Europe were at the core of this range, served as gateways to marginal areas, and witnessed Neanderthals’ bio-cultural interactions with Sapiens and Denisovans. For the first time, three PIs with vast expertise on Neanderthals’ culture, biology, and paleoenvironments will synergistically attempt to bridge the knowledge gap between the core and the periphery of their range at the time of their decline between 60-40ka. Project LAST NEANDERTHALS will 1) accurately collect, date, integrate, and model new high-resolution cultural, bio-genetic, and environmental data from understudied areas in western and central Asia and eastern and southeastern Europe; 2) provide an unprecedented perspective on the last Neanderthals’ population dynamics; 3) offer a comprehensive and compelling explanation of the mechanisms that led to their extinction by integrating data from their entire range and formulating and testing nuanced hypotheses using new models and simulations; 4) serve as a proxy for the fate shared by all archaic human groups.

Keywords: middle paleolithic,early upper paleolithic,homo sapiens,ancient dna,neanderthal,western and central asia,eastern and southeastern europe
Instantaneous Infrastructure Monitoring by Earth Observation (IIMEO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Innovation actions
Countries involved: Germany,Serbia,Italy,Belgium
Call: End-to-end Earth observation systems and associated services (HORIZON-CL4-2022-SPACE-01, 2022)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 3328935.0
EU funding (EUR): 2799597.0
Participants: 6
Project status: SIGNED

Critical infrastructures for, e.g. the transport of goods and people or the supply of energy and water, are the lifelines of our globalized society. Impairments can result in enduring supply bottlenecks, significant disruptions to public safety or other dramatic consequences. Currently used monitoring processes for these infrastructures are costly, difficult to implement in isolated areas, nonuniform due to heterogenous technical solutions and poorly scalable or automatable. The project Instantaneous Infrastructure Monitoring by Earth Observation (IIMEO) contributes to an end-to-end solution for the operational real-time, high-resolution monitoring of critical infrastructure by means of an innovative observation payload for a future LEO constellation. Our system concept focusses on data availability within less than 1 hour from user request to information delivery by AI-based processing approaches implemented on space-qualified on-board hardware. To provide a persistent weather-independent monitoring service with an improved spatial resolution of up to 50 cm, we propose a novel sensor configuration consisting of a 35-GHz-SAR sensor in combination with optical cameras. Based on existing technology from scientific institutions and European space industry, hard- and software will be further developed up to TRL 6. Development will be carried out in close cooperation with a railway company as a pilot user to define use cases for commercial applications based on the requirements of industry and public services. The end-to-end prototype service including on-board processing will be demonstrated within a final flight campaign. A roadmap will describe the further exploitation of the project results and outline further applications of the technology to other infrastructure systems. A follow-up demonstrator mission in 2026/27 is envisaged to showcase the monitoring of railways from space on a global scale on TRL 7.

Keywords: instantaneous earth observation,infrastructure monitoring,on board autonomy,persistent observation,end to end eo systems
The role of symbiont diversity in resilience to temperature fluctuations. (SymFlux)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

Beneficial microbes are essential for many animals and mutualistic interactions must be able to withstand environmental changes such as temperature fluctuations. However, with changing ocean temperatures induced by climate change, it is unclear whether symbioses will be able to adapt, leaving marine organisms at risk. Therefore, this proposal will characterize how bacterial symbionts respond to changing temperatures and identify whether microbes can increase symbiotic resiliency to temperature stress. To pursue this topic, the symbiosis between the squid Sepiola affinis and its symbionts (V. fischeri and V. logei) will be used. The project uses a unique squid husbandry facility to pursue three main objectives. The first objective will characterize initial and persistent colonization in the S. affinis light organ. Using confocal microscopy and genetic labelling, strain behaviors during colonization will be described. The second objective will examine how temperature affects colonization. The third objective will screen Vibrio spp. for growth under temperature fluctuations. RNA sequencing and metabolomics will be used to identify molecular mechanisms underlying resilience to temperature fluctuations. Finally, genetic modification and both in-vitro and in-vivo growth assays will test whether molecular candidates promote temperature resilience. The project will have a two-way transfer of knowledge, with the researcher providing knowledge of Vibrio spp. and bacterial genetics with the host institution providing bioinformatics and small molecule analysis. The SymFlux project will position S. affinis as a model for symbiosis research in Europe as well as contribute knowledge of how symbioses can adapt to climate change.

Keywords: symbiosis,host microbe interaction,vibrios,vibrio fischeri,vibrio logei,sepiola affinis,colonization,temperature resilience
SOLUTIONS FOR CIRCULAR WATER AND DECENTRALISATION (SOLUCIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Innovation actions
Countries involved: Greece,Netherlands,Germany,Spain,United Kingdom,Italy,France,Belgium,South Africa,Switzerland
Call: New circular solutions and decentralised approaches for water and wastewater management (HORIZON-CL6-2024-CIRCBIO-02, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 5241313.75
EU funding (EUR): 4994729.13
Participants: 16
Project status: SIGNED

SOLUCIR addresses the need for more widespread uptake and deployment of circular and decentralized water management solutions in the face of expanding urban populations and inadequate infrastructure, particularly in peri-urban areas. The project aims to address key challenges across technical, financial, regulatory, and societal domains that hinder widespread adoption of these solutions, that could offer effective alternatives for, but also resilient upgrades to, existing centralized water systems (where available). The project learns from 23 Inspirational Pilots (IPLs) where novel technologies already exist on the ground and leverages insights and lessons learned to develop 5+1 Pathfinding Studies (PFSs) in collaboration with utilities and local stakeholders to demonstrate the effectiveness, scalability, and benefits of decentralized solutions and directly address barriers for large scale deployment. This process is supported by novel tools and methods for integrating decentralized solutions with centralized systems and by enhancing the operations of decentralised systems through digital innovations. Critical to SOLUCIR is the development of comprehensive risk assessment tools encompassing health, operational, and environmental risks, complemented by targeted policy recommendations and societal interventions. SOLUCIR emphasizes financial sustainability, proposing innovative financial mechanisms and circular business models. The project places a strong focus on capacity building and upskilling at key decision levels (utility, local and regional authorities) and ensures the widespread dissemination of its findings and experiences. To realize its ambitions, SOLUCIR unites a strategic alliance of top universities, advanced research institutions, forward-looking water utilities, and key experts in socioeconomics, business, and innovation, blending cutting-edge knowledge with practical experience to generate tangible impacts.

Keywords: decentralised water systems system resilience water technology water innovation uptake integrated water systems
Towards an Integrative Model of the Relationship Between Episodic Memory and Novelty Detection Through a Behavioural and Neuropsychological Approach (DENOVO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

As memorizing new information relies on distinguishing the new from the familiar, novelty detection is closely tied to memory. Yet, the exact nature of this link remains unclear—are they two sides of the same function or rather distinct yet interacting processes? Critically, there are different types of novelty: absolute (new stimulus) or contextual (familiar stimulus in unexpected context). The ultimate goal of the MSCA "DENOVO" project is to develop an integrative model of the relationships between episodic memory and these novelty types. Specifically, I will test the way novelty types interact with memory: unitary relation for absolute vs. independence for contextual. I will design innovative tasks and use complementary approaches of neuroimaging, neuropsychology, and cognitive psychology in 3 work packages—(i) a correlational study in volunteers aged >55 to examine the relationship between novelty and memory, (ii) a neuropsychological study with memory-impaired patients (probable Alzheimer’s disease (AD) and amnestic Mild Cognitive Impairment) to probe the impact of underlying brains network dysfunction and to characterize the patterns of impairments across novelty types at AD stages, and (iii) analysis of longitudinal data from a cohort of subjects aged >60 to study the temporality of changes in novelty types in relation to memory decline and brain regions atrophy. Beyond ground-breaking advances in understanding memory function, the insights will be of great interest to clinicians for both diagnosis and rehabilitation of memory disorders. Altered precociously in AD, absolute novelty may be an early diagnosis marker while contextual novelty, which boosts memory encoding, may be a compensation strategy. Personally, thanks to the expertise of my host and secondment labs, DENOVO will equip me with essential technical and clinical skills, advancing my long-term career goal of conducting research using neuropsychological approaches to study episodic memory function.

Keywords: episodic memory memory alzheimer s disease aging novelty detection mild cognitive impairment
Campus Iberus International Doctoral Programme of Interconnected Universities (IberusINTERDOC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: MSCA COFUND 2023 (HORIZON-MSCA-2023-COFUND-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2704800.0
EU funding (EUR): 2704800.0
Participants: 5
Project status: SIGNED

IberusINTERDOC is an International Doctoral Programme of 4 Interconnected Universities of Campus Iberus aimed at recruiting 23 Doctoral Candidates (DCs) of excellence to develop Interdisciplinary PhD projects for 48 months in Campus Iberus territories. Campus Iberus is the Consortium of International Excellence of the Ebro Valley bringing together four public universities from neighbouring regions in northeast Spain: Universidad de Zaragoza, Universidad Pública de Navarra, Universitat de Lleida and Universidad de La Rioja. Campus Iberus strategy is set on the principles of aggregation, internationalisation and specialisation on five strategic areas, in line with the priorities of the smart specialization strategies (RIS3) of the four regions involved (Aragon, Navarre, La Rioja and Lleida in Catalonia): 1) Agri-Food & Nutrition; 2) Health Technologies; 3) Energy & Sustainability; 4) Social & Territorial Development; 5) Circular Bio-Economy. DCs will be recruited in 2 calls open for 2 months to apply for a variety of research topics across those 5 areas. Appointments will be no later than M12 (1st call) and M19 (2nd call) to offer 48 months contracts. The last 6 months of the contracts will be fully financed by own funds of Campus Iberus universities to cover 4 years even if exceeding the programme (M60+6). The programme will offer DCs excellent supervision and professional development, counting with preidentified potential supervisors proving experience and work in multidisciplinary projects and large networks of collaborators. A total of 116 academic (48%) and non-academic partners (52%) have associated to this programme to provide secondments, trainings and career enhancing opportunities, besides the networking events and special training programme organised by Campus Iberus. This programme will make an imprint on the internationalisation and excellence that is long lasting at the institutional, regional, national and international levels.

Keywords: sustainability,environment,agro,food,nutrition,health,technology,energy,circular,economy,social,territorial,development