Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Support to RESAVER Pension Fund - Horizon Europe (Horizon Europe Work Programme 2021-2022) (RESAVER Pension Fund)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Other ERA
Destination: Other ERA
Action type: Coordination and support actions
Countries involved: Belgium
Call: Support to RESAVER Pension Fund (HORIZON-WIDERA-2021-RESAVER-IBA, 2021)
Start date: 2022-01-01
End date: 2024-12-31
Duration (months): 36.0
Total project cost (EUR): 1161350.0
EU funding (EUR): 850000.0
Participants: 1
Project status: CLOSED

The RESAVER Pension Fund is a special multi-country, cross-border occupational pension vehicle contributing to the removal of the obstacles of researchers’ mobility in Europe through enabling mobile employees of research institutions to remain affiliated to the same supplementary pension fund when moving between different countries and changing jobs. The RESAVER Pension Fund stands for free movement of workers as a fundamental principle of the Treaty enshrined in Article 45 of the Treaty on the Functioning of the European Union and wants to create a future in which employees, researchers specifically, can move and work in EU without any additional difficulties related to accumulation of occupational and personal pension provisions. The overall aim of the establishment of the RESAVER Pension Fund corresponds to the strategic objectives of the European Union on the creation of the European Research Area to enhance the competitiveness of a knowledge-based Europe. The more research institutions join the RESAVER Pension Fund, the more effective it will be in removing pensions as a barrier to the mobility of researchers in Europe and the more it will fulfil its purpose of supporting the creation of a European research area. The general objective of the RESAVER Pension Fund is to continue expanding its membership in all countries of the European Economic Area and support the third fiscal year of its core operations while the fund grows. Specifically, this means: · To ensure that the service providers carry out their roles effectively and deliver a smoothly operating pension process; · To finance the fees essential for the ongoing running of the RESAVER Pension Fund; · To ensure that the pension fund has the capacity to enroll new potential organisations. The RESAVER Pension Fund was established in Belgium and received its authorisation to operate from the Belgian regulator (FSMA) on October 28, 2016.
Surrealism as Multicultural Experience: The Transatlantic Bonds of the Surrealist Group and the Self-Reevaluation of Latin-American and European Cultural Identities (MULTISURREALISM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-10
End date: 2027-01-09
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 3
Project status: SIGNED

By studying a set of surrealist cultural journals edited during the 1930s and 1940s, MULTISURREALISM will examine the intercultural exchange between surrealist Latin American and European artists and writers, to analyze the way their ideas, agreements, tensions, and debates had an impact on the revalorization of the Latin American artistic and symbolic production, as well as on the understanding of European civilization. With an interdisciplinary approach (Literature Studies, Visual Arts Studies, Graphic Design, Discourse Studies, History of Ideas), the research will focus on the literary and artistic production of the surrealist multicultural network, as it has been manifested in magazines such as Minotaure (Paris, 1933-1939); VVV (New York, 1942-1944); Dyn (Coyoacán, 1942-1944); El Uso de la Palabra (Lima, 1939); Las Moradas (Lima, 1947-1949); Mandrágora (Santiago, 1938-1942) and Leitmotiv (Santiago, 1942). The overall hypothesis states that the surrealist multicultural relation promoted a different glance over Latin American culture since the assumption that Latin America is a land where surrealism arises naturally belongs to an ethnocentric perspective constructed by both European and Latin American surrealists. Still, it simultaneously allowed them to question the assumed subordination of Latin American culture, giving a new shape to its identity and influencing its Literature until the rise of the Latin American Boom. The project aims to connect different archive materials to analyze what this movement wanted to express, and also its unintentional effects and underlying meanings, to study its impact as a multicultural group. The final goal is to broaden the perspective about surrealism's role in the Latin-American culture of the XX Century, which promoted transatlantic bonds that have enriched both cultures and opened them to the world. This plan will be developed at Universitat Pompeu Fabra under the supervision of Dr. Domingo Ródenas de Moya.

Keywords: surrealism literature art multiculturalism cultural identity intercultural exchange internationalism cultural magazines study archive ethnocentrism transatlantic studies
Mix and Match: One-step activation for targeted drug delivery (OatLive)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Current clinically approved drug delivery systems, such as liposome, PEGylated liposome, and polymeric micelle, predominantly rely on passive accumulation within tumor tissues by diffusion through the defective tumor vessels during circulation. The targeting efficacy toward cancer cells is very limited due to their inadequate interaction with cancer cells. The attachment of targeting ligands to nanocarriers has demonstrated its effectiveness in enhancing binding affinity and, consequently, facilitating cellular uptake via receptor-mediated endocytosis. However, the conventional methods employed for ligand attachment suffer from harsh conditions, low efficiency, and limited control over ligand orientation. These drawbacks compromise the targeting performance and are believed to result in the current absence of a targeted drug delivery system on the market. In this project, we propose a simple, efficient, and mild attachment method to spontaneously activate on demand nanocarriers. This innovative approach has the potential to have a multi- level effect, first to revolutionize various fields, including drug delivery, diagnostics, and nanotechnology, by providing advanced tools for targeted therapies and diagnostics. Secondly, by developing novel methodologies that can be applied to existing technologies to enhance uptake, localization, and efficacy while minimizing systemic toxicity thus potentially shifting the health- economic balance for some treatments which were previously inaccessible.
Labour and Practices of Women in Publishing During the Democratic Transitions in Argentina (Ada Korn Editora, 1984-1989) and Spain (Ediciones Torremozas, 1982-1986) (FEMBOOKS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

This research project is framed at the intersection between the history of publishing, sociology and literature studies, with specific focus on gender, bibliodiversity in the creative economy of publishing, and the narrative shaping of democracy. It proposes a comparative study of the yet-to-be-explored archives of two small, independent publishing houses established and led by women in mutual contexts of post-dictatorship transition to democracy: Ada Korn Editora, founded by Ada Korn in 1984 in Buenos Aires, in the immediate aftermath of the 1976-1983 civic-military dictatorship in Argentina; and Ediciones Torremozas, founded by Luzmaría Jiménez Faro in 1982 in Madrid, following Franco’s 36-year dictatorship in Spain (1939-1975). During this period of social effervescence, AKE and ET expanded the limits of the literary field challenging whom and what is considered published literature supporting cultures of democracy within the publishing sector. Scholars have announced the crisis of print culture aggravated with the increasing power of digital platforms and the erosion of the authority of public intellectuals. Nonetheless, the economic and cultural weight of creative industries is significant and the publishing industry remains a privileged space to spread ideas, and affect the social and political landscape. The current democratic deficit various countries experience, such as Argentina following the 40th anniversary of the return of democracy, reinforce inequalities within creative industries that reproduce disparities when deciding which narratives circulate. This endangers bibliodiversity and gender equality. The case studies will be analysed within the transnational field of literature by focusing on material, aesthetical, and social dimensions.

Keywords: sociology of literature history of publishing
Tackling and investigating the South-Kivu mpox outbreak (MBOTE-SK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Belgium,Congo, The Democratic Republic of the,Canada,France,United States,Switzerland
Call: Mobilisation of Emergency funding for Mpox outbreak research response (HORIZON-JU-GH-EDCTP3-2024-Mpox, 2024)
Start date: 2024-08-01
End date: 2027-01-31
Duration (months): 30.0
Total project cost (EUR): 2066281.25
EU funding (EUR): 1263076.25
Participants: 8
Project status: SIGNED

With the Mpox Biology, Outcome, Transmission, and Epidemiology in South Kivu (MBOTE-SK) project, we seek emergency funding to address one of the most alarming mpox outbreaks currently unfolding: the ongoing emergence of a new lineage of monkeypox virus (MPXV, clade Ib) in South Kivu, Democratic Republic of the Congo (DRC). This outbreak is particularly concerning due to its extensive human-to-human transmission through sexual contact in a densely populated region characterized by a large sex industry and significant cross-border movement. Without swift intervention, there is a high risk of the outbreak spreading internationally, penetrating sexual networks worldwide. In this project, we will leverage our extensive experience with mpox outbreaks in the DRC and our current presence in South Kivu to tackle this outbreak through a combined approach of research and response. To achieve this, we will build on local and national expertise and strengthen the DRC's research institutions, and align with the international response. This project has four foundational pillars, each designed to simultaneously strengthen the response and comprehensively describe clade Ib MPXV, including its clinical presentation, mode of transmission, at-risk populations, and virological evolution. Pillar 1 strengthens active case finding and epidemiological surveillance to map and monitor the spread of clade Ib MPXV. Pillar 2 supports real-time genomic surveillance to track the genetic evolution of the strain. Pillar 3 enhances clinical care through an in-depth clinical characterization study. Pillar 4 engages key populations (including sex workers) to study community spread, vaccine hesitancy and stigma. These four pillars eventually feed into Pillar 5, by informing on how to best target the Ministry of Health’s planned vaccination campaign (with the Modified Vaccinia Ankara vaccine) and documenting its impact and real-world effectiveness (using the established platforms of Pillars 1-4).

Keywords: mpox,sti,
Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases (CohesiNet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United Kingdom,Ireland,Austria,Netherlands,Spain,France,Portugal
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2883266.74
EU funding (EUR): 2649823.2
Participants: 22
Project status: SIGNED

Cohesin is an evolutionarily conserved multi-protein complex that belongs to the structural maintenance of chromosomes protein family. It can topologically entrap DNA molecules mediating sister chromatid cohesion, a function important for accurate chromosome segregation and DNA replication/repair. It has been recently discovered that cohesin can generate and maintain DNA loops by an ATPase-dependent in cis DNA tethering activity, called loop-extrusion, critical for organising chromatin architecture and regulating gene transcription, and as such thought to be important for cell differentiation and development. However, the molecular mechanisms by which the cohesin complex achieve these key cellular functions remain to be elucidated. Mutations in genes coding for cohesin and its regulators lead to a class of developmental disorders collectively called “cohesinopathies” and have been found in several types of cancer. Nonetheless, the pathogenesis of these devastating human diseases is poorly understood. CohesiNet aims to answer outstanding questions in the field of cohesin biology by a highly innovative research programme. This consortium will investigate fundamental mechanisms on how cohesin acts during chromosomal cohesion and loop extrusion, identify regulatory modules of cohesin functions and get insights into the molecular bases of cohesin-related diseases. These ambitious goals will be achieved using multi-disciplinary hypothesis-driven and exploratory approaches while promoting a culture of communication and cooperation among academic and private institutions across the European Union. A team of ten PhD students will be trained by the CohesiNet consortium to address these scientific questions and be empowered with skills that will enhance their career perspectives, while experiencing first-hand the value of Open Science and the importance of inclusion, transparency, accessibility and integrity in scientific research.
Atlas of the Human Deep Brain Nuclei, Connections, and Vasculature (DeepBrainVascu)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-03-01
End date: 2024-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Deep-brain stimulation, DBS in short, is one of the most promising surgical treatments for movement disorders such as Parkinson’s disease (PD), and more recently, neuropsychiatric diseases such as obsessive compulsive disorder. During DBS surgery, a microelectrode is lowered deep into the brain with the aim to stimulate small subcortical nuclei in order to alleviate disease related symptoms such as rigidity and tremor as seen in patients with PD. Studies using DBS in PD patients show that a suboptimal placement of electrodes in, for example, the Subthalamic Nucleus (STN) or Globus Pallidus (GP), can yield changes in cognitive processes (e.g., attention, mental speed, response inhibition) and affective states (e.g., depression, hypomania, anxiety, hypersexuality, and hallucinations). These unwanted side effects of DBS are speculated to be the result of the stimulation of subareas other than the motor zone within these nuclei, the stimulation of white matter connections, or the dysregulation of blood flow to neighboring areas. Our aim is to create an atlas of the human Deep Brain nuclei, connections, and Vasculature (DeepBrainVascu) to substantially improve the outcome of DBS by significantly reducing unwanted side effects.
Translational optoelectronic control of cardiac rhythm in atrial fibrillation (TransRhythm)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1999999.0
EU funding (EUR): 1999999.0
Participants: 1
Project status: SIGNED

It’s my conviction that, one day, we will enable the human heart to terminate its own rhythm disturbances and thereby restore its normal rhythm at any place and time. Such acute restoration of cardiac rhythm would not be based on traumatizing electric shocks, but on generation of bioelectricity by the affected heart itself. In order to explore this paradigm-changing approach for ambulatory shock-free control of cardiac rhythm, I will integrate the unique advances of genetic engineering, computer modelling, tissue engineering and micro-optoelectronics. To determine the advanced and translational potential of such optoelectronic heart rhythm control, the most prevalent cardiac arrhythmia will be targeted, atrial fibrillation (AF). To this purpose, we will first engineer human atrium-sized 3D models of AF from fully functional conditionally immortalized human atrial cardiomyocytes expressing light-gated ion channels. To realize and explore optoelectronic rhythm control in these models, customized multi-electrode-LED arrays (MELAs) will be integrated to gain full control over bioelectricity generation by precisely tailored illumination. Such illumination will be accomplished by a modular interactive optoelectronic system allowing continuous, accurate and realtime monitoring-based activation of specific LEDs in the MELAs. Insights from these studies will guide the application of this approach in pig models of AF to determine its feasibility, safety and therapeutic implications. From design to interpretation, all these studies will be supported by advanced computer simulations to realize an iterative process of optimization for maximum project outcome. Establishing translational optoelectronic control of cardiac rhythm is expected to break new ground by revealing unique novel insights into AF mechanisms and management. This project could thus provide distinctively innovative therapeutic options, while generating novel tools and concepts in medical research and care.

Keywords: atrial fibrillation,gene therapy,cardiac arrhythmias,cardiac electrophysiology
SETDEPLOY - Driving the implementation of the SET Plan Action 8 (SETDEPLOY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Sweden,Norway,Spain,Belgium,Italy,Germany
Call: Support to the activities of the SET Plan Key Action area Renewable fuels and bioenergy (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 651873.56
EU funding (EUR): 574473.9
Participants: 6
Project status: SIGNED

Bioenergy and renewable fuels are essential to achieving the EU's zero-emissions target and transitioning to a clean energy system. Bioenergy is essential for decarbonizing energy and transport sectors, especially long-haul modes like aviation, shipping, and road freight, where electrification remains challenging. The Strategic Energy Technology (SET) Plan identifies bioenergy and renewable fuels as indispensable technologies for meeting renewable energy and decarbonization targets. However, achieving these outcomes requires coordinated actions among stakeholders, alignment of priorities across member states, and effective implementation of enabling policies and technologies. The updated Implementation Plan of IWG8 must address emerging priorities, such as those introduced in the Fit for 55 package, REPowerEU, REFuelEU Aviation, and FuelEU Maritime initiatives, as well as ensure alignment with the EU’s 2030 and 2050 climate goals and the recently launched Competitiveness Compass for the EU. The SETDEPLOY project directly responds to these challenges by acting as a facilitator and enabler of the SET Plan’s objectives in renewable fuels and bioenergy. The project will strengthen stakeholder networks, foster innovation ecosystems, and ensure effective collaboration among member states, associated countries, and relevant stakeholders. By supporting the update and implementation of the SET Plan Implementation Plan, SETDEPLOY will address new policy priorities while facilitating the deployment of technologies and solutions at scale. Through its activities, SETDEPLOY will facilitate the critical next steps for advancing deployment, monitoring progress, and fostering cross-border collaboration, ensuring the EU meets its climate, energy, and sustainability targets while securing a competitive and resilient bioenergy and renewable fuels sector.

Keywords: set plan renewable fuels bioenergy climate change biofuels biogas energy security