Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Growing patient-own blood vessels to treat renal and vascular diseases (XS Graft)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Renal and vascular diseases are one of the leading causes of death globally. This includes conditions such as cardiovascular disease, renal failure, and peripheral vascular disease. Vascular grafts are a critical treatment for these conditions. For example, in renal disease (RD) patients, using vascular grafts to maintain a vascular access point is a lifeline that enables them to receive critical dialysis treatments. However, the almost daily cannulations damage the patient’s veins and arteries, and eventually even synthetic grafts can no longer be used to maintain access. A key challenge in vascular graft development is creating a graft that closely mimics the natural properties of human blood vessels. This includes flexibility, durability, the ability to repair itself, and compatibility with the body's biological environment to reduce the risk of clotting, inflammation, infection, and rejection. CuroTis aims to drive the next generation of body-own regenerative medicine. We have developed the XS Graft, a proprietary synthetic polymer rod that directs formation of body-own vascular tissue by triggering a foreign-body response at the precise location. This leads to the formation of a new blood vessel in just 4 weeks, after which the rod can be removed. Because this tissue is body-own and fully mimics a natural blood vessel (including endothelial layer formation), it removes the risk of tissue rejection, inflammation, and thrombosis associated with fistulas and synthetic grafts. The rod has already been safety tested in first-in-human clinical trials. We will first target this technology at late and end stage RD patients where it has the potential to save 26,000 avoidable deaths resulting from failed access points in end stage RD in Europe alone. The XS Graft will reverse the RD patients’ journey, enabling them to continue to receive haemodialysis treatments where current solutions have failed.

Keywords: haemodialysis,renal disease,vascular graft,autologous tissue,vascular access,
2D Nano Hybrid Systems: interfacing biomolecular motors with nanopores in 2D materials (2D-NanoHyb)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Croatia,Switzerland
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 146049.6
EU funding (EUR): 146049.6
Participants: 2
Project status: SIGNED

Interfacing the solid-state electronics with biological systems has been a long-standing challenge in nanobiotechnology. Creating nanobio hybrids would enable harnessing the remarkable capabilities offered by solid-state materials and biological molecules, such as proteins, enzymes, DNA etc., at the same time. Two-dimensional (2D) materials are among the most prospective building blocks for future-generation electronic and biosensing devices due to their exceptional optoelectronic and mechanical properties combined with their atomic thickness. Their ultimate thinness has been considered as a remarkable advantage for nanopore-based sensing, and they have been widely investigated as 2D solid-state nanopore platforms for single-molecule sensing. The goal of this proposal is to push further the development of 2D nanopores by developing new protocols for creating interfaces between 2D materials and biomolecular motors. Attaching the enzyme motor, such as DNA helicase, to a nanopore made in 2D material would introduce an active control in nanofluidic transport of single-molecules and ions. Such hybrid platforms presents a step forward in uniting biological inspiration and nanoscale engineering, offering unprecedented levels of control, precision, and versatility at the nanoscale. The future direction holds promise across a wide spectrum of applications, from fundamental scientific research to transformative technologies that could impact fields as diverse as nanobiotechnology, personalized medicine and diagnostics, environmental sensing, nanorobotics, and many more.

Keywords: nanopore sensing,2d materials,nanobiotechnology,hybrid materials,molecular motors,functionalization,solid state nanopores,sequencing
EpiSyStem - SNLS application (EpiSyStem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Belgium
Call: HORIZON-MSCA-SNLS-2021-IBA (HORIZON-MSCA-2021-SNLS-IBA, 2021)
Start date: 2021-07-27
End date: 2022-01-26
Duration (months): 6.0
Total project cost (EUR): 4285.71
EU funding (EUR): 3000.0
Participants: 1
Project status: CLOSED

“The Marie Skłodowska-Curie actions pay particular attention to physical accessibility and inclusion and foresee financial support for the additional costs entailed by recruited or seconded researchers with disabilities.”
Affordable, efficient, safe and compact solid hydrogen storage to support maritime decarbonisation (MINCATEC ENERGY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Hydrogen will play a vital role in the decarbonisation of hard to abate sectors, especially energy intensive industry, shipping, railway and seasonal energy storage. However, storing hydrogen is notoriously difficult, and raising safety challenges. Mincatec Energy is developing a game changing solution that enables high density hydrogen storage at low pressure at ambient temperature. Working in partnership with leading metal hydride researchers from the Neel Institute in Grenoble, we reached major milestones in bringing this technology from lab to market. In 2022, our technology was successfully integrated in a lightweight vehicle and in 2024, we began work on two large scale stationary storage projects. These achievements have been recognised through numerous awards, and this year, our first equity fund raising will enable us to build our first manufacturing capabilities. Our next major R&D objective is to adapt our technology for the maritime and inland waters shipping sector. This represents a potential market of around 6.5Bn € by 2050, facing strong pressure from European policy to decarbonise. However, R&D investment and risks associated with reaching this market are high. We require investment from the EIC Accelerator to improve storage density, certify our product regarding maritime requirements and build an on-board vessel demonstrator to validate our technology. Following this, we anticipate an additional investment to adapt and grow our manufacturing capability for the shipping industry.

Keywords: hydrogen,storage,metal hydride,decarbonisation,maritime shipping,circular economy,efficiency,safety
First AI based scalable 1-click Plug&Play customs compliance SaaS with fastest (30 to 60 seconds) and cheapest industry-agnostic solution for customs data compliance and strategic trade optimisation (TRAIDE-AI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2210000.0
EU funding (EUR): 2210000.0
Participants: 1
Project status: SIGNED

The global trade market rose above pre-pandemic levels late 2021, having a value of €27.1 T. The global logistics software market, Traide’s TAM, has a current value of ~€11.8B for 2024 growing by ~€17.56B in 2029 (CAGR of 8.3%). 80 % of delayed shipments are linked to missing consignee information, poor descriptions, or incomplete information. International trade law is constantly evolving, e.g. 7,000+ new trade laws were introduced as a consequence of the 2008 financial crisis, Brexit (increased the number of customs declarations by 30%), Russia-Ukraine conflict (sanctions in the form of 10 restriction packages have been implemented till date). This trend is growing further, for example with the Carbon Border Adjustment Mechanism (CBAM) introduced in late 2023. Companies need to increase efforts for managing export control and staying on top of embargos. Thus, the demand for an efficient way to always keep abreast with all these changes is on the rise. Challenges in customs processes harm the European economy, e.g. if companies are not able to keep up with the regulations and choose to not operate internationally as well as millions of backlog in repayment requests (published by customs authorities). Our vision is to become the global leading provider for customs compliance. We provide the only Plug & Play deep learning AI-based tool for customs data creation, regulation and audit that simplifies product classification and enables scaling international trade processes.

Keywords: deep learning,big data,international trade,harmonized commodity description and coding system,hs,customs tariffs,supply chain management,customs,customs clearance
Geometric and harmonic analysis for weights (GEOHARWeights)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: SIGNED

Our research focuses on the study of geometric and analytical aspects of various classes of weight functions that are ubiquitous in harmonic analysis. The main goals of this project are to substantially improve some of the well-known fundamental norm inequalities for Muckenhoupt weights (the Reverse Hölder Inequality) and BMO functions (the John-Nirenberg estimate), to continue developing the theory of Békollé-Bonami weights in all dimensions, and to describe the geometry of the extension domains for both classes of weights. Our methods combine classical tools in harmonic and geometric analysis with more sophisticated probabilistic techniques that have been employed in the theory of Calderón-Zygmund operators in the setting of non-doubling measures, and in sharp maximal inequalities. The proposal is based at the Department of Mathematical Sciences (IMF), NTNU, Trondheim, Norway, with Karl-Mikael Perfekt as the supervisor of the fellowship. In addition to the research outcomes, the plan include lecturing and supervising activities, dissemination of the results in conferences, and participation in outreach activities organized by the NTNU. The research will be carried out within the research group "Fourier Analysis and Multiplicative Analysis", at the same department, whose Principal Investigator is Kristian Seip.

Keywords: weights,functions of bounded mean oscillation,extension domains,reverse h lder inequality,maximal functions
Smart Integration of Waste and Renewable Energy for Sustainable Heat Upgrade in the Industry (SUSHEAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Research and Innovation actions
Countries involved: Spain,Sweden,Norway,Romania,Italy,Slovenia,Greece,United Kingdom,Austria,Hungary
Call: Development and pilot demonstration of heat upgrade technologies with supply temperature in the range 150-250°C (HORIZON-CL5-2022-D4-01, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 4673743.75
EU funding (EUR): 4673743.75
Participants: 15
Project status: SIGNED

SUSHEAT develops and validates, up to TRL 5, 3 novel enabling technologies: high-temperature heat pump (HT-HP), Phase Change Material (PCM) bio-inspired Thermal Energy Storage (TES) system, and Control & Integration Twin (CIT) system; for heat upgrade in top-level labs. It will attain an efficient heat upgrade up to 150-250 °C thanks to the use the innovative Stirling-based HT-HP, working with hellium and enlarging the industrial exploitability of heat upgrade systems, reaching a COP up to 2.8 for temperature ratios of 1.2. The integration of innovative TES will ensure a reliable, flexible, and customizable heat delivery with full decoupling from any waste heat recovery and renewables availability. Moreover, its CIT will provide user-friendly tools and a digital twin for the control system and advising industrial stakeholders, based on smart decision-making algorithms. SUSHEAT will bring an effective self-assessment of the most suited heat upgrade system integration including not only its key enabling components but, beyond, also leveraging on off-the-self RES-based units, particularly solar thermal collectors even enlarging the feasibility of Concentrating Solar Power systems that can extend its operation working at low temperature. Two case-studies are replicated for validation at TRL5, and 4 additional cases are analysed in-depth to cover other sectors as Pulp & Paper, Beverages, Petrochemical, Textile & leather and basic metals. By developing industry-focused self-assessment tools, and directly engaging different industrial stakeholders, SUSHEAT will contribute to identify the target industrial processes and sites which would benefit from the concept, rising awareness of various heat upgrade benefits within the industry and providing solutions to maximize the industrial efficiency while contributing to the sector’s decarbonization, reducing the GHG emissions up to 145 gCO2/kWh (excluding solar contribution and based on EU 2020 intensity and the use NG).

Keywords: high temperature heat pump heat upgrade industry renewables energy sources thermal energy storage digital twin
Innovations for vaccines against helminth infections (WORMVACS2.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Spain,Gabon,Uganda,Australia,United Kingdom,Italy,United States,Switzerland,Croatia
Call: Vaccines 2.0 - developing the next generation of vaccines (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 7475302.49
EU funding (EUR): 7475302.49
Participants: 13
Project status: SIGNED

Infections with parasitic worms (helminths) continue to cause a massive global health burden. Yet, effective vaccines to enable control and elimination of helminth infections do not exist. Primary reasons for this are that target discovery approaches are not well-developed, protective immune mechanisms are only partially clarified at best, production platforms tailored to specific helminth vaccine requirements are not available, and a pipeline for selecting and rapidly progressing pre-clinical and clinical vaccine candidates is generally lacking. Moreover, controlled human infection models are only now being developed and optimized for some of the most important human helminths. These models have not yet been widely implemented in vaccine development programs to date. The objective of WORMVACS2.0 is to establish an effective pipeline to support helminth vaccine development focusing on schistosomes and hookworms, and ultimately the control and elimination of some of the world’s most devastating and persistent Neglected Tropical Diseases (NTDs). We aim to achieve this through the development and application of an innovative approach leveraging controlled human infection models, novel platforms for helminth vaccine/vaccine antigen production, experimental animal models, and improved target discovery methodology applying state-of-the-art immunological profiling to identify correlates and signatures of protection. WORMVACS2.0 will advance scientific and clinical knowledge of host immunity in response to helminth infection, apply innovative and sustainable platform technologies tailored to the next generation of effective vaccines against helminth infections of global importance. The project will produce a diversified portfolio of hookworm and schistosome vaccine candidates ready for progressing to clinical testing and conduct a phase 1 clinical trial to advance an mRNA platform based schistosomiasis vaccine.

Keywords: helminth,vaccine platform,target discovery,immune profiling
Anti-democratic/anti-gender nexus in Bosnia and Herzegovina (AntiGenderInBiH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Slovenia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 171399.36
EU funding (EUR): 171399.36
Participants: 1
Project status: SIGNED

The recent rise in anti-democratic discourses and politics in Europe has been linked with a rise in opposition to women’s and LGBTIQ* rights. I call this link the “anti-democratic/anti-gender nexus” and argue that we need to explain the exact nature of the link, to understand the rise of, and develop strategies to combat, de-democratization processes in Europe. The project AntiGenderInBiH focuses on how gender and sexuality are governed and framed in Bosnia and Herzegovina (BiH). As a potential EU accession candidate, BiH has positively identified the need to promote diversity and equality within its population. Yet opposition to them, and particularly to LGBTIQ* rights, has been increasing. Working with Prof. Roman Kuhar at the University of Ljubljana, I will pursue two connected research objectives. Firstly: to analyse the “anti-democratic/anti-gender nexus” empirically in the BiH context. By applying a triangulation of methods, including Interpretative Policy Analysis and Critical Frame Analysis, I will analyse policies developed on the national and the level of the two entities Federation of BiH and Republic of Srpska relating to the governance of gender and sexuality issues as well as discourses on these issues mobilized by media and activists. Through this, I will identify potential anti-democratic/anti-gender frames, policies and networks, in BiH. Secondly: to conceptualize the “anti-democratic/anti-gender nexus” theoretically, combining my data with a critique of existing theoretical explanations. This will provide novel theoretical explanations that will allow myself and other scientists in the field to identify the links between anti-gender and anti-democratic discourses and politics and explain the rise of the “anti-democratic/anti-gender nexus”. The novel empirical insights and successful conceptualization can serve as a basis for policy- and decision-makers in BiH and the EU to tackle the problem of increasing attacks on democracy and human rights.

Keywords: anti gender,de democratization,bosnia and herzegovina,women s and lgbtiq rights,gender and sexuality policies,framing of gender and sexuality
INTERoperable cloud-based solution for cross-vector planning and management of Positive Energy Districts (InterPED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Spain,Germany,Switzerland,United Kingdom,Serbia,Belgium,Romania
Call: Interoperable solutions for positive energy districts (PEDs), including a better integration of local renewables and local excess heat sources (HORIZON-CL5-2023-D4-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3868866.02
EU funding (EUR): 3299368.22
Participants: 14
Project status: SIGNED

InterPED aims to enable the concept of PEDs via sector coupling, cross-vector integration, demand flexibility and consumer engagement, while improving utilisation of local RES, storage and excess/waste heat (E/WH) sources. InterPED will couple RES, storage and E/WH sources (community assets) available in the pilots with the necessary know-how and ICT expertise to ensure improved operation of PEDs and grid robustness. This will allow InterPED’s end users (aggregators, service providers, urban planners) to deliver benefits to both, grid stakeholders (DSO/TSOs) and final consumers (and prosumers). To do so, InterPED will deliver a scalable and adaptable cloud-based platform composed of analytical, modelling and optimization services for planning, supervision and control of integrated PEDs (including power, heating and cooling, mobility). Optimized PED operations will be demonstrated at pilot sites, while enabling a cooperative demand response (DR) strategy at community/district level. In addition to automated control actions, InterPED intends to engage the consumers via community building (e.g. CECs or RECs), representing a still largely untapped source of flexibility, while enabling them to play an active role in grid balancing. By making it cloud-based and by ensuring system interoperability (both syntactic and semantic), InterPED will enable aggregators and actors positioned to adopt proposed business model (e.g. ESCOs, energy retailers, DSOs) to deploy the InterPED solution immediately almost anywhere, while reducing the cost to its scalability. The key strategy to ensure solutions will work well in an everyday context of consumers, is that InterPED will involve the consumers (community) and service providers in the design of the solutions through participatory co-design processes. InterPED will verify the technical and commercial feasibility of its integrated package in four large-scale pilots, each representing an existing PED.

Keywords: cross vector integration cooperative dr strategy community engagement non energy sector coupling platform integration and interoperability smart grid energy communities community trading