Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative Applications of Extracorporeal Photopheresis in Solid Organ Transplantation (exTra)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Austria,Spain,Netherlands,Italy,United Kingdom,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2613103.2
EU funding (EUR): 2613103.2
Participants: 21
Project status: SIGNED

Organ transplantation remains the only definitive treatment for end-stage heart, lung, liver or kidney disease. Early transplant outcomes are now generally excellent, dramatically reducing patients’ mortality and morbidity. Nevertheless, transplantation still faces significant obstacles, especially long-term immunosuppression-related toxicity and chronic decline of transplant function, which are the leading causes of transplant failure. To break these barriers, which represent a very significant societal and economic burden in the EU, there is a need for innovative therapies to lessen our reliance on conventional immunosuppression and better control non-resolving inflammation. Extracorporeal photopheresis (ECP) is now being investigated as a personalized, adjunct immunosuppressive therapy in some organ transplant settings. However, ECP is regarded as a controversial therapy, primarily because current understanding of its pharmacological actions is incomplete, but also because there remain questions about optimal manufacturing processes, quality-control and personalized clinical indications. The exTra project asks whether a better mechanistic understanding of ECP can guide us more efficiently towards novel applications. Specifically, exTra brings together European experts in clinical transplantation, immunology, pharmaceutical development, computational biology and medical device manufacture to address key questions through a coordinated, interdisciplinary effort. exTra proposes 10 independent doctoral research projects with the ambition of providing its trainees with a comprehensive understanding of basic and translational immunology, especially relating development and licensing of new immunotherapies. Through its research and training activities, the exTra project will contribute to scientific advancement and innovation in Europe, ultimately leading to societal and economic benefits stemming from clinical innovations in transplant immunotherapy and beyond.

Keywords: organ transplantation,immunosuppression,extracorporeal photopheresis,clinical investigation,quality management,medical device development,t cells,macrophages and dc,donor specific antibodies
The role of shared micromobility modes in the resilience of urban transportation systems: New challenges and opportunities (ROMSUR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

Increasing urban traffic and environmental challenges have driven the investigation, development, and diversification of sustainable transportation alternatives globally. The resilience of these alternatives has also been considered equally important in recent research in order to ensure a more safe, accessible, and equitable transportation system during severe disruptions. However, there is a lack of comprehensive evaluation system through which urban and transportation planners can assess and plan for transport resilience in their own geographical contexts. In this regard, this research proposes a model to evaluate an overall resilience of shared micromobillity systems through their commonly available usage patterns in light of current challenges and future opportunities. Specifically, it takes major shared micromobillity programs (e.g., station-based bike-sharing (SBBS), free-floating bike-sharing (FFBS), free-floating e-bike sharing (FFEBS), and free-floating e-scooter sharing (FFESS)) operating in Europe as examples to empirically analyze the mobility patterns of their users across three timescales: before, during, and after the pandemic. As a methodology, this study will utilize a combination of quantitative and qualitative techniques. The expected outcomes will help in improving governance and an appropriate appraisal of sustainable urban transport alternatives, which are still in its infancy. The resilience assessment tool will further help develop long-term systems for measuring and executing mobility plans on both sides of the mobility equation: supply and demand.

Keywords: shared micromobility transport resilience mobility as a service urban sustainable active mobility covid 19 europe
The early sequestered germline of fungi - spatial distribution, mechanism and generality across the kingdom (FunGerm)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2497523.0
EU funding (EUR): 2497523.0
Participants: 1
Project status: SIGNED

The FunGerm-project aims to investigate the phenomenon of an early sequestered germline in the fungi. As of today, it is well known that in unitary animals the germline is defined early during development, while in fungi, plants, and other metazoans, the current dogma is that the germline is defined much later in development, meaning that mutations that have accumulated over growth can enter the germline. Recent, and yet unpublished, whole-genome-sequencing data in my group show the unexpected pattern of an early sequestration of the germline in the basidiomycete fungus Marasmius oreades, suggesting convergence in evolution of this key trait among major eukaryote lineages. M. oreades grows in fairy rings: circular, underground mycelia common in lawns and grasslands across the northern hemisphere. At the edge of the ring, the annual, sexual, fruiting bodies (mushrooms) develop from the mycelium. In recent years, we have developed the system as a natural, long-term evolution experiment to study the rise and fate of new mutations over sexual generations. With an ERC Advanced grant we will be able to use this system to fully explore the finding of an early sequestered germline, and also expand it to identify the breadth of occurrence across the fungal kingdom. Specifically, I propose to use a wide range of approaches and M. oreades as model organism to investigate: I) The spatial distribution of the somatic and germline cell-lines in mycelia, II) The mechanism determining and controlling germline segregation, and III) The mutation rate and spectra of the different cell lines. Furthermore, we aim to investigate IV) the prevalence of an early germline sequestration across basidiomycetes and other fungi. With the FunGerm-project we will thoroughly test if, and how, an early germline sequestration has evolved multiple times independently, in different eukaryote kingdoms, and thereby empirically contribute to the conceptual link between development and evolution.

Keywords: mycology,development,convergent evolution
Semiclassical Spin Dynamics in Condensed Phase (SCSD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Quantum mechanical, spin dynamic calculations for NMR purposes, rapidly becomes very complicated when the studied spin systems increase in size. In this project we aim to study methods in which semiclassical molecular dynamics are explored to tackle this problem. Methods for semiclassical approximations have since long times been established within the fields of radical chemistry and optical spectroscopy research but are little explored within the field of NMR. We intend to explore methods where in addition to a smaller completely quantum mechanically described spin systems are investigated, the complete (large) nuclear surrounding is included in a classical manner. More specifically we will add Hamiltonian terms of the Caldeira-Leggett type and eventually simulate the anharmonic environment with ab initio molecular dynamics or empirical force fields. The benefit of the proposed strategy is that matrix size increases linearly with the number of nuclei included instead of exponentially if the environment can be described classically. This will be done by a step by step project plan in which during the earlier work packages investigations of spin systems without the environment included is done. Then once, we have established suitable quantum dynamics methods, we will proceed to include the environment. If this succeeds and we manage to correctly calculate spin dynamics with the impact of the environment in terms of relaxation taken into account, we will continue to the later work packages and try to use this to aid NMR pulse design. If this is successful, this project will open doors to more efficient NMR simulations and provide quantum physical insights to NMR dynamics.

Keywords: semiclassical molecular dynamics,quantum dynamics,solid state nmr
Peripheral Biomarker Based Combinatorial Early Diagnostics for Dementia (CombiDiag)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Canada,United States,Luxembourg,China,United Kingdom,Austria,Denmark,France,Italy,Spain,Türkiye
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 2410693.71
EU funding (EUR): 2160201.6
Participants: 22
Project status: SIGNED

CombiDiag DN aims to develop an AI-data-driven peripheral biomarker based combinatorial diagnostic protocol for early stages of Alzheimers disease (AD), a major form of dementia, and to train a new generation of fellows for this interdisciplinary field. Dementia, a devastating disease of older age, is the challenge of our lifetime and one of the Societal Challenges listed by the UN Sustainable Development Goals and Horizon Europe. CombiDiag responds to this challenge to establish a much-needed DN to carry out an integrated study of minimally invasive and cost-effective peripheral biomarkers, including body fluid markers from blood, urine and saliva, and digital markers from speech, motor functions and sleep for developing the combinatorial early AD diagnostics. The consortium comprises nine academic and eight non-academic institutions across Europe, USA, Canada, and China. It synergises leading academic and industrial experts worldwide to build a triple-i research and training platform for the training of a new generation of Fellows to take early AD diagnostic research to a new level. Fellows will be trained under the Vitae Researcher Development Framework innovatively combined with the CombiDiag platform for triple-i scientific and transferable skills as well as personal quality, creative thinking, and business mind-set. The DN has a highly innovative research programme for the discovery of peripheral AD biomarkers, detection techniques, AI/data driven technology, clinical validation, and integration into trial designs. The advances in CombiDiag research will enable a case finding tool at primary care level for helping achieve improved drug discoveries, disease-modifying treatments, preventive strategies and care provision for AD. CombiDiag will deliver 10 highly-skilled, creative and entrepreneurial Fellows, setting them on a path to successful careers in academia or industry to ensure that the medical and societal challenges imposed by AD are met.

Keywords: alzheimer s disease,early diagnosis,peripheral biomarkers,non invasive,blood,saliva,urine,speech,motor function,biosensors,bioinformatics,business model
Social Prescribing to promote and improve access to health and care services for people in vulnerable situations in Europe (SP-EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Germany,Austria,United Kingdom,Poland,Spain,Croatia,Belgium,Slovenia,Denmark,Switzerland,Portugal
Call: Access to health and care services for people in vulnerable situations (HORIZON-HLTH-2024-CARE-04-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7300532.24
EU funding (EUR): 6970269.74
Participants: 25
Project status: SIGNED

Social Prescribing (SP) is an innovative solution to bridging the gap between primary health care and non-clinical supports and services within the community. SP enables general practitioners who identify health-related social problems to refer patients to a so-called link worker. The link worker provides personalized support and helps these patients to access community resources by addressing any barriers that may exist. SP is an approach to integrate health and social care and strengthen community orientation. SP thereby mitigates the effects of social determinants of health on health outcomes. However, SP has not been tailored to the needs of people in vulnerable situations yet and the effectiveness of SP to improve their access to health and care services remains unknown. The overall objective of SP-EU is to assess the potential of SP to promote and improve access to health and care services for people in vulnerable situations, focusing on three primary target groups: LGBTIQ persons, refugees and first-generation immigrants and older adults living alone. SP-EU follows a mixed-methods approach: SP adaptations will be co-created with the target groups, to adapt them to their specific needs and social contexts. A pragmatic randomized controlled trial will assess the effectiveness of the adapted SP to improve access by randomizing 1,776 patients in eight EU countries to receive SP or care as usual. A qualitative analysis in five European countries will explore enabling and limiting factors to the implementation of SP from different stakeholders’ perspectives. Additionally, we will communicate and disseminate results and translate them into policy action. SP-EU will enable health care systems to implement SP as a scalable, safe, cost-effective and people-centred solution to provide equal access to sustainable care. Thus, SP-EU will enable the transformation of European health care systems to equitable, community-based, people-centred and integrated health care.

Keywords: social prescribing lgbtiq refugees immigrants older adults general practice family medicine primary care community randomized controlled trial co creation qualitative analysis
ENabling Intelligent Omni-surfaces for Smart and efficient wireless communication (ENIOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Wireless technology has become a fundamental component of human daily life in societies. It is expected that by 2030, the demand for data rates will reach 1 Tb/s due to the increase in simultaneous wireless connections: almost 1000 times more than 5G technology. Although 5G wireless networks are now a reality and, undoubtedly, a transformative factor for both society and the economy by delivering an unprecedented fabric of massive connectivity to millions of users and interconnected devices, they cannot efficiently support such high data traffic in the future due to their limited spectral efficiency (around 30 bps/Hz). To tackle this issue, 6G technology is envisioned to attain spectral efficiencies of around 100 bps/Hz with ultra-low latency to support diverse applications. One of the most promising approaches to enable true Smart Radio Environments with 360º coverage is based on the concept of simultaneous transmitting and reflecting intelligent omni-surfaces (STAR-IOSs). In STAR-IOSs, the incident wireless signals on a patch-array or a metasurface-based structure can be (at the same time) reflected by and transmitted through the STAR-IOS. While STAR-IOS technology has the potential to be a key enabler for new use cases in 6G, it is yet to be understood how its true electromagnetic nature will affect the fundamental limits of STAR-IOS communications and impact their practical applications. The key goal of ENIOS project is to create and validate physically-motivated mathematical models and tools for STAR-IOS communications, that can be used for realistic system design in 6G communications. This will be accomplished by integrating tools from multivariate statistics, electromagnetics, and information theory. Aspects like (i) Accurate modeling for practical STAR-IOS communications;(ii) Mathematical tools for performance analysis and system design of practical STAR-IOS communications; and (iii) New architectures for STAR-IOS communication, will be addressed in ENIOS.

Keywords: communication theory,information theory,6g communications,intelligent communications,metasurfaces
Implementing Cationic Paths in Aliphatic C-H Oxidation (ICAT-PACHO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

Finding new reaction paths and establishing new frontiers in C-H bond oxidation represent breakthroughs in organic chemistry. Going beyond preliminary findings discovered by the fellow Dr. Marco Galeotti, this project will focus on the unprecedented implementation of cationic paths in C-H bond oxidation, diverging from the ubiquitous radical paths. The proposed objective represents a change of paradigm in C-H functionalization from a mechanistic perspective and in a broad perspective in organic chemistry, because it will deliver a novel methodology to access unique and intriguing cyclobutane structures by single-step functionalization of aliphatic C-H bonds. These transformations will be carried with a view to sustainability through the employment of earth abundant 3d catalysts and an eco-friendly oxidant such as hydrogen peroxide. This proposal will benefit from the accumulated wealth of experience of Marco Galeotti in organic chemistry and in the mechanistic aspects of the factors governing reactivity and selectivity on aliphatic C-H bond functionalizations. This, in combination with the supervision of Prof. Miquel Costas, an internationally recognized expert in the chemistry of biologically inspired oxidation catalysis applied to organic chemistry, will offer the possibility to uncover valuable mechanistic insights of this new oxygenation pathway. The proposed project will represent a milestone in synthetic organic chemistry because it will deliver a wide variety of stereo- and enantioselective four-membered carbocycles in the oxidation of cyclopropyl derivatives for a broad spectrum of aliphatic C-H bonds. This transformation will be also applied in late-stage C(sp3)-H diversification of natural product and pharmaceutical, by placing this proposal in the realm of society-changing outcomes.

Keywords: aliphatic c h oxidation,cationic paths,bioinspired catalysts,high valent oxo species,cyclopropane
Digital Twin Anomaly Detection Decision-Making for Bridge Management (DTADD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway,Netherlands,Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 3
Project status: CLOSED

Bridge infrastructure in Europe has great economic, social and cultural value. Nevertheless, many of the assets which are part of this network are in poor condition, which has been recently evidenced by the collapse of several bridges. The available human and economic resources are simply not enough to repair, maintain or replace all bridges - part of the European network. Therefore, improvements on the current bridge management and operation system is urgently needed. During this fellowship an open-source digital twin anomaly detection decision-making (DTADD) tool will be developed to support the preventive conservation of existing bridges in Europe. This innovative tool will improve the bridge management by aiding the implementation of a reliability-based bridge management approach (RBBMA), thus contributing to bridge cultural heritage (CH) conservation and sustainability by extending their service life and reducing management costs. The DTADD fellowship has two specific objectives. The first objective is to build digital twin (DT) models of heritage/conventional bridges to assess and identify the highest performing anomaly detection algorithm (ADA) for damage and/or significant decay detection. Its second objective is to develop an ADA-informed open-source decision-making tool based on a RBBMA, to assess the need for bridge intervention while explicitly considering the bridge’s CH value. This fellowship will be carried out mainly at OsloMet, Norway, with a six-month secondment at TU Delft, Netherlands. The research experience, skills and knowledge obtained during the fellowship will help the experienced researcher to become a leading international expert on the conservation of bridges and will aid him to achieve his goal of becoming an independent researcher and obtaining a tenure track position. Furthermore, this fellowship is aligned with the Transport action of the European Green Deal as well as with the UN Sustainable Development Goals (SDGs).

Keywords: structural health monitoring,cultural heritage,assets management,finite element methods,damage detection,anomaly detection,bridge management