Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cryo-EM structural analysis of small nuclear ribonucleoprotein particles (snRNP) biogenesis (StructuRNP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

The spliceosome is a multi-megadalton enzyme that catalyses the excision of non-coding introns from nuclear pre-mRNA. It is assembled from five small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors, while each snRNP contains a unique small nuclear RNA (snRNA, U1-U5) and is bound by the heptameric Sm-ring. Acquisition of the Sm-ring is a key quality control step in snRNP biogenesis, defects of which are linked with several human diseases. In humans, snRNP biogenesis requires at least 15 proteins, including the 9-subunit survival of motor neuron (SMN) complex. The SMN complex carries out the regulated and specific loading of the Sm ring onto snRNA. Recent studies have revealed the structure of several key proteins that play a role in snRNP assembly, however the complete structures of either the SMN complex alone or with interacting Sm ring and or the snRNP as a whole, are lacking and culminate to a big gap in our knowledge of the snRNP assembly. In this proposal, I will reconstitute key steps in snRNP biogenesis in humans and will determine their structures using cryo-electron microscopy and cross-linking mass spectrometry. I will study how the SMN complex specifically loads the Sm-ring onto U1 snRNA, as a model snRNP. Additionally, purification and structural analysis of endogenous SMN complex will reveal SMN complex stoichiometry and validate the in vitro work. The structures will reveal the interacting partners and the structural transitions within the assembled snRNP and will enable structure-guided biochemical and tissue culture validation of SMN complex function, while my background in protein biochemistry and human tissue culture makes me ideally suited to carry out this high-impact project. StructuRNP will provide first insights into the molecular events and choreography of the spliceosome, providing a leap in our understanding of spliceosome function and thus will have far reaching implications for RNA and spliceosome fields.

Keywords: cryo em,snrnp,snrna,protein nucleic acid interaction
Disentangling the multitrophic interactions of the supervector Bemisia tabaci to potentially use its symbiotic communities to reduce plants viral-vectored diseases. (GuardSym)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Agriculture is facing constant pressure to increase food production to fulfill human population demands. This has been accomplished by the use of intensive agricultural techniques. The increase of global temperatures together with intensive techniques like worldwide movements of plant material, use of monocultures, and abuse on insecticides have modified the trophic chains in agricultural systems. As a consequence, there is an unprecedented increase in emergent plant viral diseases in the last decades. Most of these viruses require an insect vector for their transmission. Unfortunately, some vector insects have been favored by intensive agriculture. Indeed, the whitefly Bemisia tabaci has become a worldwide supervector and is the cause of the global emergence of begomoviruses and criniviruses. This whitefly has developed resistance to many insecticides and developing new control techniques is a must. Recently, a population modification strategy has been applied to mosquitoes, displacing natural populations and replacing them with virus-resistant ones that are no longer able to transmit human diseases. This success has been achieved using Wolbachia, a bacterial symbiont present in many insects, that can confer virus-resistance phenotypes to its host. Interestingly, B. tabaci presents a rich bacterial symbiotic community, including Wolbachia, that can be naturally manipulated through hybridization. This offers the unique opportunity to unravel the multitrophic interactions that occur between B. tabaci, its symbionts, the vectored virus, and the plant. Using integrative frameworks to study the insect and the plant physiology, the virus transmission, the symbionts dynamics, and the cross-talks between them (their transcriptomes) can lead to the discovery of new symbiotic virus-resistant phenotypes in B. tabaci. If this is achieved, it will be a keystone to develop further population modification strategies to spread symbionts conferred virus-resistances.
Patient Empowerment through Predictive PERsonalised decision support (PEPPER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Spain,Romania,United Kingdom,United Kingdom
Call: Self management of health and disease and decision support systems based on predictive computer modelling used by the patient him or herself (H2020-PHC-2015-single-stage, 2015)
Start date: 2016-02-01
End date: 2020-03-31
Duration (months): 50.0
Total project cost (EUR): 3548071.25
EU funding (EUR): 3548071.25
Participants: 6
Project status: CLOSED

This proposal is for a personalised decision support system for chronic disease management that will make predictions based on real-time data in order to empower individuals to participate in the self-management of their disease. The design will involve users at every stage to ensure that the system meets patient needs and raises clinical outcomes by preventing adverse episodes and improving lifestyle, monitoring and quality of life. Research will be conducted into the development of an innovative adaptive decision support system based on case-based reasoning combined with predictive computer modelling. The tool will offer bespoke advice for self-management by integrating personal health systems with broad and various sources of physiological, lifestyle, environmental and social data. The research will also examine the extent to which human behavioural factors and usability issues have previously hindered the wider adoption of personal guidance systems for chronic disease self-management. It will be developed and validated initially for people with diabetes on basal-bolus insulin therapy, but the underlying approach can be adapted to other chronic diseases. There will be a strong emphasis on safety, with glucose predictions, dose advice, alarms, limits and uncertainties communicated clearly to raise individual awareness of the risk of adverse events such as hypoglycaemia or hyperglycaemia. The outputs of this research will be validated in an ambulatory setting and a key aspect will be innovation management. All components will adhere to medical device standards in order to meet regulatory requirements and ensure interoperability, both with existing personal health systems and commercial products. The resulting architecture will improve interactions with healthcare professionals and provide a generic framework for providing adaptive mobile decision support, with innovation capacity to be applied to other applications, thereby increasing the impact of the project.

Keywords: decision support,mobile health
Mechanisms of synaptic growth and plasticity (Neuronal Trafficking)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 2
Project status: CLOSED

My long-term goal is to understand the cellular and molecular mechanisms that govern synaptic growth and plasticity, and how dysfunction in these pathways contributes to disease. Neurons are the most morphologically diverse cell type whose morphology determines many functional aspects of a neuronal network. The primary shape of a neuron is established during axon and dendrite outgrowth and synapse formation, but is subject to subsequent modifications by physiological events. In response to changes in synaptic activity, neurons can alter both pre and postsynaptic elements of the synapse. Defects in synaptic morphology and in activity-dependent plasticity are a hallmark of several neurodegenerative and cognitive disorders. It is therefore critical to know the basic mechanisms by which neurons acquire their shape and change it in response to activity, and to dissect the genes that regulate these processes. To address these questions, this proposal is divided in the following aims: 1) To dissect the postsynaptic role of the Ral/exocyst pathway in synaptic growth and activity-dependent plasticity 2) To uncover novel regulators of neuronal membrane trafficking . My strategy is to use the relatively simple nervous system of Drosophila to uncover novel cellular and molecular mechanisms that control synaptic development and plasticity, in order to understand how membrane traffic is regulated to form and modify neuronal structures. Because 75% of all human disease genes have related sequences in Drosophila and nearly a third are predicted to have functionally equivalent counterparts, I expect that these studies in Drosophila will contribute to the dissection of the mechanisms that, when disrupted, may lead to disease. This will help identify points of intervention, therefore directing novel therapies to help curing or ameliorating the symptoms present in many neurological disorders.

Keywords: synapse,membrane trafficking,exocyst,rab gtpases,synaptic plasticity,synaptic growth,drosophila
A novel approach to determine canopy nitrification in the phyllosphere of European forests: combining multiple isotope tracers and proteogenomic techniques (NITRIPHYLL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-06
End date: 2018-06-05
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Forest canopies play a significant role in regulating carbon and water exchanges with the atmosphere, with profound effects on our climate. However, their role in altering the chemical composition of precipitation and, consequently, the nutrient cycling within a forest has been less investigated. This is particular relevant for nitrogen (N)-limited forests in the Northern hemisphere, which have been exposed to a rapid human-induced increase in Ndep over the last decades. Much of the scientific attention has been focused on the role of Ndep in enhancing forest C-sink, while we still need to elucidate the fate of Ndep when entering forest and its contribution to N cycling. In particular, it is still not clear whether Ndep is retained, taken up and/or altered by biological transformations when interacting with tree canopies. By applying a quadruple isotope approach I recently demonstrated the occurrence of in-canopy biological nitrification of atmospheric N for UK forests at high Ndep. Hence, NITRIPHYLL intends to extend the multiple isotope approach a) to enlarge the range of conditions under which the process is demonstrated to occur, b) to investigate difference between species in the proportion of microbiologically-derived NO3 and c) the reasons of these differences. Furthermore, by using proteo-genomic techniques we aim to characterize phyllosphere microbial communities involved in canopy nitrification. We will consider i) forests along a gradient of climate and Ndep within the well established EU-ICP forest network and ii) existing N manipulation experiments. NITRIPHYLL for the first time merges two separate research avenues, i.e., the investigation of canopy nitrification with the study of the occurrence, abundance and diversity of bacteria communities in the phyllosphere. Thus, the project will contribute to providing a deeper understanding of how the phyllosphere affects the N, and consequently C, cycling within forests in relation to climate and Ndep.

Keywords: atmospheric nitrogen deposition,nitrification,stable isotopes,forests,carbon cycle
FERROHUB (FERROHUB)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Sweden,Sweden
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

Today’s energy grids are moving from a concentrated model to a distributed model. Renewable energy sources like solar PV and wind power systems are becoming increasingly popular, but also represent a challenge for energy grids. As a result, new more efficient energy structures are emerging, like Smart Grids, Micro Grids and Virtual Power Plants (VPP’s), but inverters on the market are not suitable, since they lack features such as integrated storage capabilities and bidirectional power flow. Another challenge the grid is facing is the spreading of electric vehicles and the electrification of transport in general, which calls for safe and quick vehicle charging. Ferroamp Elektronik (Sweden) is proposing the FerroHub, an innovative electronic hub leveraging several patents, which fully supports smart grids. The solution incorporates a PV inverter, energy storage and the necessary hardware and software to handle power flow to and from the network, as well as other innovative technologies developed by Ferroamp that augment the stability of the power network and empower the users to gain control of their energy costs. Big loads (in the case of EV charging for example) will not be a problem anymore, since FerroHub can use the integrated storage to provide the excess power needed. Another advantage is the absolute scalability and flexibility of the FerroHub system with only three types of modules required for any installation. The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy and to plan all activities for deploying a large scale pilot supported by an energy utility company/energy service provider. The SME Inission partners with FerroAmp as manufacturer of all electronic components in the FerroHub.

Keywords: energy grids,electronic hub,pv inverter,energy storage
Triaxial Magnetic Fields for the Control of Bioactive Materials in Bone Engineering (MATRIX-B)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Magnetic tissue engineering envisions the development of complex systems in which magnetic elements are exploited as remotely controlled multidimensional tools with potential for diagnostic and therapeutic actions. Such a magnetic material can be imagined as a fixed “station” that offers a long-living assistance to tissue engineering, providing thus a unique opportunity to adjust the material activity to the personal needs of the patient. In the development of biomaterials for bone repair one of the major concerns is to increase their integration and remodeling rate. The possibility of favoring bone tissue engineering applications by magnetic stimulation in patients with reduced endogenous potential is a key issue, in consideration of the progressive ageing of the population for which more effective and personalized regenerative therapies will be increasingly demanded in the incoming decades. The original main driving idea of this project is the use triaxial magnetic fields for the creation of a conceptually new type of bioactive materials able to be manipulated directly in situ. To date all studies with magnetic biomaterials have been carried out only in presence of uniaxial fields. The very novelty of this project is the enhanced magnetic susceptibility in three dimensions by applying a triaxial magnetic field to a magnetic particles suspension. In principle, with such a configuration it is possible to magnetically drive the self-assembly of the particles producing extraordinarily well-controlled structures at the microscale. This novel approach, involving the use of triaxial fields, is expected to culminate in a new generation of materials with a specific, continuous and reloaded control from an external supervising center and new characteristics in tissue engineering, such as multiple uses, possibly multipurpose delivery and, furthermore, improved mechanical properties since magnetorheology under triaxial fields is still completely unexplored field of research.

Keywords: triaxial magnetic field,magnetic biomaterial,magnetorheology,self assembly,bone regeneration
GatE-coNtrollEd Superconducting TransIStors (GENESIS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-05-01
End date: 2022-07-31
Duration (months): 15.0
Total project cost (EUR): 119285.71
EU funding (EUR): 100000.0
Participants: 2
Project status: SIGNED

The global internet traffic is expected to grow by 55% year-over-year until 2030, reaching more than 5.000 exabytes at 1Tb/s. Current telecommunication (TLC) infrastructures are facing an impossible challenge: indeed, the limitation of current technology is basically due to the speed of current generation TLC networks, and the huge amount of data processed at network nodes. The key features expected for the 5th and 6th generation communication networks require ultra-high throughput and ultra-low latency, assuming the capacity to deal locally and externally with Tb/s bitrate. While the improved transmission bitrate will be granted using microwave (GHz) or teraHertz (THz) radio frequency signals, dealing with data sorting will, in turn, become harder and harder. GENESIS aims to pave the way to solve this TCL infrastructure problem proposing a new paradigm for electronics in which the fundamental building blocks rely on gate-controlled superconducting transistors. The foreseen superior performances for superconducting devices such as, for instance, radiation sensors and radiofrequency (RF) switches based on the application of a local electric field to superconducting weak-links will be assessed with a laboratory-scale experiment that will test the operating frequency up to 20 GHz with the pre-industrial configuration (device + pulse tube + packaging and electronics). On the business side, the project aims to perform a stakeholder analysis to validate the system’s functionalities, and the main requirements for the integration of the technology in selected application scenarios. Finally, with the support of an IP studio that will carry out a Freedom To Operate analysis, such action will result in a patentability study to determine the possibility to file new patent applications (one is expected to be submitted early in 2021) covering discoveries made during the FET Launchpad project.

Keywords: josephson effect,supercurrent,low temperature physics,quantum technology,quantum computing,supercomputing
Nanometre scale imaging of magnetic perovskite oxide thin films using scanning transmission electron microscopy (MAGIMOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

Magnetic materials are a vital part of modern society, being important components in technologies such as magnetic resonance imaging machines and hard disk drives. A common strategy to both improve existing technologies and develop new ones, is miniaturization. The most striking example being the billion-fold increase in silicon semiconductor transistor density, which fundamentally changed society since its invention in the 60ies. However, this miniaturization trend now seems to come to a slow-down as devices are shrinking to sizes where hard physical limits are setting in, and being able to image these nanoscale devices becomes ever more important. Scanning transmission electron microscopy (STEM) is a widely used imaging technique used to study such nanometre scale devices, however it does not readily provide imaging of the magnetic properties at this scale. The perovskite oxides form a materials family, which exhibits a wide range of properties including magnetism. A similar miniaturization process has been used for these materials, where making them as nanometre thick films revealed new phenomena. The most exciting being multiferroics, where an applied electric field can change the magnetic structure, and vice versa. This has attracted much interest in both making and studying these oxide materials, especially their magnetic properties, due to the great potential for new device concepts. However, due to the small sizes of these films they're often very hard to study, especially when it comes to their nanoscale magnetic structure. This action will take advantage of recently developed fast electron STEM detectors to image the nanometre scale magnetic structures of these materials directly with unprecedented resolution. Using a high-end STEM equipped with such a detector, both the magnetic and crystal structure will be studied in the same microscope. This will enable highly correlated studies of the perovskites, giving a deeper understanding of these new phenomena.

Keywords: transmission electron microscopy