Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Lipids as promising BRidge between novel disease InsiGHts and improved Therapy (LipidBRIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Belgium,Germany,Sweden,France,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 3291008.55
EU funding (EUR): 3017023.2
Participants: 26
Project status: SIGNED

Recent insights revealed new, decisive roles for lipids in cardiovascular disease, chronic kidney disease, cancer and chronic inflammation. Lipid targeting may offer novel treatment opportunities for these four high-impact diseases, complementary to the currently available, insufficiently effective therapies. However, developing effective diagnostic, preventive and therapeutic solutions requires deeper insights into lipid metabolism in disease as well as improved methods of lipid detection and imaging. Furthermore, an increasing interest in lipids in clinical applications, demonstrated by our associated partners, generates job profiles requiring novel, lipid-focused, interdisciplinary training. LipidBRIGHT is the first lipid-focused ITN designed to address the unmet medical need to i) better understand lipid metabolism in disease and ii) train young scientists in the emerging lipids field, associated technologies and clinical applications, this to speed-up understanding of lipid-associated diseases and translation into novel strategies for disease diagnosis, prevention and treatment. LipidBRIGHT comprises 6 forefront-running, interdisciplinary and intersectoral research institutes and 2 SMEs with complementary expertise in lipid-associated diseases, technology and translation, supported by 4 academic and 1 international research institute, 3 SMEs, 4 international companies, 2 stakeholder-representing organisations and 1 international organisation of mixed academic/private members. With established cooperations, we will train doctoral students around three pillars: (i) Lipid biomarkers, artificial intelligence and disease modelling, (ii) Lipid-associated pathology & disease mechanisms, and (iii) Lipid application in clinics & industry. This will provide excellent scientific, technological and transferable skills to generate innovative insights in the opportunities of lipid research, and boost EU competitiveness in lipid research, translation and application.

Keywords: lipids,fatty acids,lipidomics,biomarkers,cellular signaling
The BIOarchaeology of SOCIO-POLitical changes in AmphipolIS: Exploring the impact of broad historical trends and status quo transitions on human lifeways and deathways, through a multi-proxy approach (BIOSOCIOPOLIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece,Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-03
End date: 2024-12-02
Duration (months): 26.0
Total project cost (EUR): 153486.72
EU funding (EUR): 153486.72
Participants: 2
Project status: CLOSED

This project will develop a new interpretive model to reveal the extent to which multiple socio-political transitions, representing different forms of urbanism, affect human lifeways and deathways, in a diachronic perspective. This is achieved by implementing an interdisciplinary methodology combining archaeological and historical theory, macroscopic bioarchaeological approaches and stable isotopes. The diachronic case of Amphipolis in Northern Greece experiencing many different political models between the Late Archaic/Classical and Roman periods is an ideal case study. Human skeletal remains from 300 inhumation and 100 cremation burials, spanning between the 5th c. B.C. to 1st c. A.D. will be analyzed. Methods will include: 1) studying funerary practices and deathways, 2) investigating health and lifestyle and 3) exploring biodistance and human mobility. I will also initiate an open access collaborative morphological biodistance database to create long term impacts on human mobility studies. By moving to AUTh, I will work closely with Sevi Triantaphyllou, a top-leader in funerary practices and osteoarchaeology. Her expertise, along with resources and specialties of other distinguished staff members of School of History and Archeology provide the perfect environment for the multi-dimensional contextual training, necessary for the project and for my career metamorphosis. A period of secondment is included at BB-LAB (VUB), with Christophe Snoeck, an expert on isotopic geochemistry and a global pioneer on the topic of isotopic study of cremated human remains. My career goal is to be a research leader in Social Bioarchaeology, which this project will enable by developing an integrated method for the combined analysis of mortuary environment with lived experience. Through a multi-faceted training in core skills, along with supervision, teaching and public outreach, I will develop key resources to maximize the impact of my career advancement.

Keywords: social bioarchaeology,socio political bioarchaeology,lifeways,deathways,funerary practices,health and lifestyle,mobility,biodistance,ancient greek world,classical world
COoperative Real-Time EXperiences with EXtended reality (CORTEX2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Innovation actions
Countries involved: Germany,France,Greece,Estonia,Ireland,Belgium,Spain
Call: eXtended Collaborative Telepresence (IA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-09-01
End date: 2025-09-30
Duration (months): 37.0
Total project cost (EUR): 8787512.5
EU funding (EUR): 7997197.25
Participants: 10
Project status: SIGNED

The mission of CORTEX² is to bridge the divide between widespread video-conferencing tools and state-of-the art XR-based solutions, democratising the uptake of next-generation eXtended Reality tele-cooperation among a large number of industrial segments and SMEs. To this aim, our project will provide: (1) Full support for AR experience as extension of videoconferencing systems when using heterogeneous services end devices through a novel Mediation Gateway platform (2) Resource-efficient teleconferencing tools through innovative transmission methods and automatic summarization of shared long documents (3) User-friendly and powerful XR experiences with instant 3D reconstruction of environments and objects and simplified use of natural gestures in collaborative meetings (4) Fusion of vision and audio for multi-channel semantic interpretation and enhanced tools such as dialoguing virtual conversational agents and automatic meeting summarization (5) Full integration of IoT devices in XR experiences to optimize interaction with running systems and processes (6) Optimal extension possibilities and wide uptake opportunity through the delivery of the core system with open APIs and the the organisation of Open calls for extensions towards more technical modules and more use cases in various segments. In order to ensure large adoption and fast scaling of our extended remote cooperation solution, we will use the widespread teleconferencing solution Rainbow from Alcatel Lucent Enterprise as a backbone for our innovative extended reality based tele-cooperation concept, which counts today more than 3 million users worldwide. CORTEX will extend Rainbow to allow for fully interactive XR-based cooperation and will be demonstrated in three pilots: industrial production, business meetings and remote training. Wide uptake will be guaranteed by financement of third-party projects to allow for more technical extensions, wider use-cases and deeper evaluation and assessment.

Keywords: augmented reality,virtual reality,telecooperation
Reconstructing the Pagan Religion of Tibet (PaganTibet)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2492375.0
EU funding (EUR): 2492375.0
Participants: 1
Project status: SIGNED

Buddhism was introduced to Tibet in the 7th century CE and became the official national religion in the 8th. A small percentage of Tibetans are followers of a religion called Bön, which its adherents (Bönpos) and Buddhists alike consider to be the country’s indigenous faith. Bön came to acquire many Buddhist features but retained a strand of more archaic traditions. Since there is no evidence that these traditions were actually called Bön prior to the establishment of Buddhism, we refer to them collectively as Tibetan Pagan religion. Until now, all we knew about this religion came from a small number of early (mainly 8-11th c.) manuscripts from the Silk Road, a small cache from southern Tibet, and some ritual narratives in the literature of “reformed” Bön. This situation changed dramatically in 2005 with the discovery of a large number of manuscripts constituting the ritual repertoire of a class of priests, called Leyu, in the Sino-Tibetan borderlands. Although facsimiles of some 35,000 folios of these manuscripts have now been, or are due shortly to be, published in China, other than the PI and members of his team no one has worked on them owing to difficulties of script, language and the concepts conveyed. Preliminary investigations suggest that these texts contain genuinely archaic non-Buddhist rituals and narratives closely resembling those of the early sources that are already known. Using state-of-the-art computational humanities tools such as Handwritten Text Recognition and Natural Language Processing in conjuction with the methods of philology, comparative religion and anthropology, PaganTibet proposes to undertake a systematic study of the Leyu manuscripts, producing a searchable database of the entire corpus, an annotated catalogue of its contents as well as translations and extended summaries of a selection of its works, to provide the first-ever reconstruction of Tibetan Pagan religion.

Keywords: tibetan studies,tibetan bon religion,digital humanities,natural language processing,reconstruction of religion
Smart modular mobile biorefining of manure to zero-waste maximising resource and nutrient recovery for feed and fertiliser bioingredients in rural areas (MANUREFINERY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Spain,Belgium,Netherlands,Greece,Romania,Slovenia,Ireland,Italy,Czechia,United Kingdom,France
Call: Small scale biorefining in rural areas (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 9337440.0
EU funding (EUR): 7236512.5
Participants: 25
Project status: SIGNED

Livestock farming is a crucial pillar of the rural economy in Europe. However, it also causes pollution with a significant impact on air quality and climate change. Europe annually produces over 1.4 billion tonnes of manure, with cattle contributing 75%, and pig and chickens representing 12% each. Livestock is by far the main primary European sub-sector responsible for NH3 (~1.5Mt/y) and CH4 (~166Mt/y) emissions. Despite many efforts in the past decades, current manure management and disposal on farmland as fertilizer still poses significant pollution problems such as soil degradation, eutrophication of surface waters and pollution of groundwater. In this vein, new opportunities are foreseen for small-scale biorefineries, which have the potential to provide diversification opportunities to the rural actors. In this context, ManuREfinery aims at deploying a smart, modular, mobile and sustainable small-scale decentralised biorefinery that will convert livestock manure into added value biobased feed (microbial protein, caproic acid, protein-enriched grass cake) and bioingredients (sodium nitrate, ammonium bicarbonate, p-rich ashes) for fertilisers. The Manurefinery solution exhibits high scalability/replicability potential by integrating: 1) Advanced thermo- and bio-chemical modular and mobile feedstock conversion units. 2) Digital twin and data science for multicriteria decision making and process optimization, upscaling and replicability. 3) Sustainability (economic, social, environmental) and circularity assessment framework. 4) Strategies to boost the engagement of livestock stakeholders and enhance social acceptance of the solution. 5) New, sustainable and replicable business models for income diversification in the livestock sector. ManuREfinery will be demonstrated at TRL 6-7 in 2 pig farms (Romania and Spain), 1 cow farm (Slovenia) and 1 poultry farm (Romania), thus fostering the transition of CEE regions towards a sustainable bieconomy.

Keywords: anaerobic digestion,biorefineries,gas phase fermentation,manure,resource recovery
Evaluation of the Quality of Experience of Cochlear Implant Users Listening to Live Music Performances through Augmented Reality (ARM4CI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

Hard-of-hearing (HoH) individuals are greatly limited in their interpersonal communications leading them to social isolation and loneliness. To mitigate the communication gap, cochlear implants (CI) were invented to improve speech intelligibility. However, music perception remains severely distorted due to its innate complex acoustical properties. Since music is a ubiquitous means for socio-cultural interactions, the inability to listen to it significantly degrades the quality of life of CI users. ARM4CI aims to enable CI users to perceive and appreciate music holistically through augmented reality (AR). Its objectives include organizing a database containing multimodal data of live music performances, utilizing the database to implement an intelligent system that transforms music that will be more perceivable by CI users, and integrating it into an AR system for evaluation of the quality of experience (QoE) of CI users. ARM4CI has the potential to impact the scientific community by providing a database that enables the development of machine learning algorithms, the CI users by improving their quality of experience in music consumption, and the music industry by introducing a new paradigm of listening to live music through AR. ARM4CI will be implemented in University College Dublin under the supervision of Dr. Andrew Hines. Through this project, a two-way transfer of knowledge is achieved since it combines my experience in multimodal data gathering and analysis of music performances, Dr. Hines' experience in designing algorithms to improve speech intelligibility for HoH individuals, and UCD's capacity to host AR-driven research. The fellowship is a timely opportunity for me to achieve my career goals of securing a tenure faculty position and setting up my own research laboratory for music technology in the future.

Keywords: cochlear implants
Research on Embodied Perception and Intelligent Interaction Methods Driven by Multimodal Large Models (Embodied Perception)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

With the rapid development of artificial intelligence technology, embodied intelligence has shown tremendous potential in fields such as home robotics, medical robots, and industrial design. This research focuses on open-world embodied perception and intelligent interaction methods driven by multimodal large models, aiming to develop advanced models that achieve accurate 3D visual grounding and intelligent reasoning, thereby enhancing the perceptual and interactive capabilities of robots in complex environments. The study will explore how to utilize multimodal large models to process and integrate various sensory inputs, enabling robots to accurately perceive 3D environments, understand context, and make intelligent decisions. Additionally, this research will strive to improve robots' natural interaction capabilities with humans and the environment, including language understanding and situational adaptation. This research not only holds significant academic value and profound implications for advancing artificial intelligence and robotics technologies, but also provides innovative solutions to challenges in practical applications, contributing importantly to improving production efficiency, enhancing medical services, and elevating quality of life.

Keywords: embodied intelligence multimodal learning spatial perception 3d visual grounding intelligent reasoning
Non-invasive Enhanced Omics and AI-Led Insights in Fetal-maternal hEalth (NEO-LIFE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Greece,Estonia
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 2185791.43
EU funding (EUR): 1803600.0
Participants: 6
Project status: SIGNED

According to Eurostat, fertility rates in the EU follow a progressive decline and thus are major contributors to EU’s demographic transformation with a drop at 1.46 live-births per woman (lbw), which is well below the 2.1 lbw needed to preserve the population size. Importantly, couples pursue parenthood at progressively older ages with maternal age at childbirth increasing to 30 years. While the epidemiological link between advanced maternal age and increased risks of subfertility, aneuploidy, adverse obstetric outcomes and perinatal complications is well established, conditions such as pregnancy loss, preterm delivery, low birth weight, hypertensive disorders and diabetes continue to pose significant acute and chronic health risks. There is an unmet need for maternal/fetal medical solutions to safeguard prenatal, perinatal and the lifelong health of the mother and the child. To improve reproductive healthcare in alignment with requirements set SDG3.1 we need to develop preventive over reactive medical solutions. However, progress in this domain is hindered by the siloed nature of expertise in reproductive medicine, genomics and machine learning. Barriers such as fragmented data formats, lack of standardized protocols for data collection/storage and limited integration of genomic data into broader research efforts further impede interdisciplinary collaboration along with the fact that clinicians, researchers and engineers operate within their own specialized domains. NEO-LIFE aims to tackle these challenges via implementation of a cross-disciplinary and collaborative approach, recognizing that the complexities of reproductive health, fetal-maternal medicine and precision genomics cannot be effectively addressed within isolated sectoral silos. By bridging expertise across clinical medicine, genomics, bioinformatics and AI, NEO-LIFE fosters a synergy that accelerates innovation and ensures that cutting-edge advancements translate into tangible healthcare solution.

Keywords: reproductive genomics,non invasive prenatal diagnosis,maternal fetal health,pregnancy loss,augmented reality,artificial intelligence,decision support systems,federated data resources
Cell size as driver of stem cell aging and cancer (StemCellSize)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The failure to regenerate tissue underlies a challenging health issue in elderly. A main contributor to this decline is the loss of stem cell function during aging. Despite the essential role of stem cells, it is unclear how they fail to maintain their functions during aging and disease. I discovered a new aspect of stem cell aging in vivo: cellular enlargement. With age, stem cells increase in size leading to their functional decline. However, it is unclear how size impacts stem cell fitness. Moreover, the physiological importance of this process remains unsolved. My team at the University of Helsinki will address these questions by: (1) identifying pathways that promote stem cell dysfunction during enlargement, (2) assessing the effects of size reduction on stem cell rejuvenation, and (3) illuminating the effects of stem cell size on cancer. Supported by preliminary data, I hypothesize that cell size is a driver of stem cell aging and cancer. Using hematopoietic stem cells (HSCs) of mouse models, I will identify the molecular mechanisms impairing fitness of large HSCs. I will also perform a screen to identify pathways that modulate the size of HSCs to test for rejuvenation. These will allow me to establish how HSC size affects other cellular aging pathways, organismal health and whether this relationship is causal or correlative. I hypothesize that cellular size impacts HSCs to transform into cancerous cells. To test this, I will use differently sized, oncogenic HSCs from mice and humans to test their potential to facilitate leukemia in vivo and to investigate the underlying mechanisms of this process. The novel concepts outlined here have exceptional potential for scientific impact as they add a new paradigm to stem cell aging, provide transformative treatment perspectives and examine cancer from a new dimension.

Keywords: cell size,hematopoietic stem cells,metabolism,leukemia