Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Leveraging CRISPR-Cas for fast and accurate point-of-care diagnostics (SCOPE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Transition Challenge: Full scale Micro-Nano-Bio devices for medical and medical research applications (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 2498125.0
EU funding (EUR): 2498125.0
Participants: 1
Project status: SIGNED

In the healthcare sector, rapid and precise point-of-care diagnostics is indispensable for enhancing patient outcomes, particularly in critical scenarios such as sepsis and organ transplantations. Present In Vitro Diagnostic technologies often strike a compromise between accuracy, speed, portability, and cost-effectiveness. Immunoassays offer rapidity but sacrifice accuracy, while molecular diagnostics like PCR deliver accuracy at the expense of time and ease of use. Isothermal molecular tests, on the other hand, are swift but lack specificity. Hence, a pressing need persists for point-of-care diagnostic tools that embody user-friendliness, cost-efficiency, high accuracy, and adaptability to diverse applications. At Scope Biosciences, a spin-off from Wageningen University, we have developed and patented a CRISPR-Cas diagnostic technology (scopeDx) that harnesses the precision of PCR and the speed of isothermal amplification, delivering rapid results within approximately 30 minutes at the point of care. Futhermore, the scopeDx platform can be rapidly adapted to new applications. Our objective is to complete the pre-clinical validation of our solution to offer user-friendliness, robustness, portability, and cost-effectiveness, providing swift results directly at the point-of-care. Besides, we aim to prove the versatility of our platform, which can be extended to the detection of various pathogenic microbes (viruses, bacteria, fungi) and genomic applications (stem-cell & tissue transplantations). In essence, scopeDx constitutes a modular platform technology with the potential to revolutionize the point-of-care diagnostics market comprehensively.

Keywords: point of care,crispr cas,hla
Mobile Eukaryotic Chromosomes in Fungal Pathogens (MobiChrom)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499995.0
EU funding (EUR): 1499995.0
Participants: 1
Project status: SIGNED

Horizontal gene transfer (HGT) has significantly shaped the evolution and biology of prokaryotes. In eukaryotes, however, the dynamics, mechanisms and consequences of HGT are less well understood, mostly due to its comparatively low frequency and especially the lack of experimental model systems. Recently, I described a model system for studying eukaryotic HGT, consisting of entomopathogenic fungi of the Metarhizium genus. In this taxon, HGT occurs frequently for entire accessory chromosomes. This massive transfer of genetic material is highly specific, always involving the same chromosome, and is likely regulated by the chromosome itself. Using this unique model system, the MobiChrom project addresses key knowledge gaps of HGT in general and horizontal chromosome transfer specifically: What are the evolutionary dynamics of horizontal chromosome transfer? What are the consequences for the recipient fungus's interaction with the insect host? And what are the mechanisms mediating this specific horizontal transfer? First, I will evaluate the distribution of accessory chromosomes across five co-existing Metarhizium species to understand their transfer frequencies and the involved evolutionary dynamics, while identifying candidate genes involved in HGT or host interactions. Next, I will examine how these acquired accessory chromosomes influence the recipient fungus's interaction with the host, functionally analysing how genes on these mobile chromosomes affect pathogenicity. Finally, I will investigate the genetic mechanisms underlying horizontal transfer, identifying the signals responsible for the specific transfer of the mobile chromosome and the genes that regulate this process. Through these complementary study approaches, the MobiChrom project will advance our understanding of the impact of HGT on the biology of organisms and yield fundamental knowledge on the processes, dynamics and functional relevance of the HGT of entire chromosomes in microbial eukaryotes.

Keywords: horizontal gene transfer hgt,horizontal chromosome transfer hct,fungal accessory chromosomes,mechanisms of hct and hgt in microbial eukaryotes,entomopathogenic fungi
Brain organoid-on-chip: a microfluidic platform to study neocortical development (BROOC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

A human model of neocortical development to understand neurodevelopmental disorders such as autism spectrum disorders or intellectual disability is urgently needed. Neural 2D cultures derived for example from induced pluripotent stem cells (iPSC) have been used for many years but lack the complexity of the tissue environment essential for the functionality of the developing neocortex. A promising approach to provide controlled microenvironments that generate physiological conditions and allow controlled 3D spatio-temporal structuring is the use of Organ-on-chip (OoC) technology. This BROOC proposal aims to establish a new generation of Brain Organoid-on-Chip. To study neocortical development and test pharmaceutical interventions, this project will construct new cerebral organoid model with multi-layered cortical structures on microfluidic chip system within integrated electrode array. Moreover, the Brain Organoid-on-Chip platform has the potential to transform the field and will have many applications especially for studying neurodevelopmental disorders. By overcoming several drawbacks of currently available cerebral organoid models, it will impact on the emerging field of organoids in general spanning from organoids used as alternative methods for animal experiments to cerebral organoids generated from diverse species used as a tool to study the molecular mechanisms of brain evolution.

Keywords: organ on chip,brain organoid,3d cell culture,hydrogel
STE(A)M for Home economics And Research ExchangE (SHAREE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Estonia,Finland,Ireland
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1221388.76
EU funding (EUR): 1221388.76
Participants: 3
Project status: SIGNED

STE(A)M for Home economics And Research ExchangE (SHAREE) aims to develop a European-scale research and innovation based hub at Tallinn University - Science Kitchen, with a sustainable management and research performance, strong networking and finance generation capacity to become an independent and internationally recognised actor in the field of Home Economics. Science kitchen will be a new product, a new environment that unites classroom, kitchen and lab. Science kitchen bridges various disciplines through collaboration and initiates dialogues between stakeholders for the benefit of wider society (in the context of e.g. climate, public health and educational challenges). Thereby Science kitchen helps to up-cycle the Home Economics area in Estonia and develop the awareness and the use of its results to tackle several international modern challenges. STE(A)M is a corner stone for interdisciplinary collaboration inside and above the boarders of Tallinn university in SHAREE. Home Economics implementation in the EU countries will be mapped and connected with STE(A)M subjects to give policy recommendations for home economics education. Various disciplines are invited to co-design interdisciplinary Science kitchen activities. This Twinning provides the capacity to create new and impactful research and innovation in the field of Home Economics. SHAREE enables to advance the quality and volume of Home Economics research in Estonia and the EU in cooperation with the international project partners and increase the impact of the research locally, nationally and internationally, with a specific focus on the policy relevance of the research ideas. So far mainly feminine subject area advantages through SHAREE as STE(A)M fosters gender equality by uniting experts and researchers from various disciplines. The interdisciplinary experience in SHAREE will be analysed and recommendations will be put together for working across disciplines.

Keywords: home economics,ste a m,education,interdisciplinarity
Bioinspired Oxidation of Hydrocarbons in Confined Spaces (ConfiMet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

Selective functionalization of C-H bonds in hydrocarbons is a grand challenge that chemists have tried to address for decades drawing inspiration from enzymatic oxidation reactions, with limited success. The mimicry of metalloenzymes has typically focused on the metal center, overlooking crucial aspects of the enzymatic machinery: secondary coordination effects, molecular recognition, and confinement within the isolated active site of the protein. Herein, well-established coordination manifolds for Fe- and Mn-based oxidation of C-H bonds will be melded to a synthetic molecular receptor. The novelty of the resulting metallo-cavitand receptors lies in the positioning of the reactive metal center in close proximity to a binding pocket with robust molecular recognition features. The proposed reactions will exploit a structured microenvironment based on carefully designed non-covalent interactions. The designed hosts will bind hydrocarbons and related substrates in a confined space in close proximity to a reactive metal species, promoting site-selective oxidation dictated by the orientation of the substrate within the receptor rather than by the innate reactivity of the different C-H bonds in the structure. ConfiMet will deliver unprecedented site-selective functionalization reactions in molecules with multiple chemically equivalent C-H bonds, of important impact in the development of sustainable production methods for drugs and other chemical specialties. This project is a unique opportunity for the researcher to combine existing skills in coordination chemistry and transition metal catalysis with supramolecular chemistry concepts. The stimulating environment provided by the Institute of Computational and Catalysis, a research unit of excellence at Universitat de Girona (Spain), will allow the candidate to develop leadership, communication, and independent thinking skills, enhancing her career prospects in the transition to an independent academic position.

Keywords: transition metal catalysis,bioinspired oxidation,molecular recognition,cavitand receptors
Revealing multi-scale community dynamics supporting species coexistence in threatened oceanic liverwort-rich communities (LIVCOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-23
End date: 2028-03-22
Duration (months): 24.0
Total project cost (EUR): 267418.56
EU funding (EUR): 267418.56
Participants: 2
Project status: SIGNED

The microbial communities living in and on plants (microbiomes) are key drivers of plant success and community composition. This interaction between macro- and micro-communities is rarely incorporated into ecological theories about species coexistence, but the advancement of sequencing technologies now opens up opportunities to build experimental models for these complex feedbacks. The small size and haploid dominance of bryophytes (mosses, liverworts, and hornworts) make them prime candidates for tractable, compact models of plant community microbiome dynamics. LIVCOM focuses on understanding the diversity of rare and threatened oceanic liverwort-rich communities (OLCs) and developing resources to use them as just such a model. LIVCOM integrates ecological, phylogeographic, and genomic methods to characterize the community, intraspecific, and microbial diversity of OLCs. Beyond new scientific knowledge and resource development, LIVCOM will also be able to inform conservation efforts for the rare plants found in OLCs. LIVCOM will be implemented at the Natural History Museum of the University of Oslo (UiO), with a secondment to the Royal Botanic Garden Edinburgh. LIVCOM will prepare the fellow for a career as a bryophyte microbiome expert in the European academic sector by increasing her international networks, breadth and depth of biological expertise, and intersectoral experience.

Keywords: microbiome,bryology
A new European blueprint for circular bioplastics upcycling solutions (ReBioCycle)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Ireland,Netherlands,Italy,Spain,Finland,Germany,Malta
Call: Recycling bio-based plastics increasing sorting and recycled content (upcycling). (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 10416832.6
EU funding (EUR): 7497001.0
Participants: 20
Project status: SIGNED

ReBioCycle proves a portfolio of bioplastic sorting and recycling technologies within 3 complementary waste-processor-centric HUB at DEMO scale and in the real operational environment the effective and efficient recycling of 3x types of bioplastics (PLA, PHA, Mater-Bi) to demonstrate higher impact of obtaining the same or superior grade recycled polymers and other higher value applications. - NL HUB chemical technology upscaling to TRL 6. Using TORWASH technology to recycle PLA & PHA polymers (500 kg each. KPI: at least 1 m3 solution of monomers from each of PLA/PHA free of solids. The NCTP Group waste sorting site of Heerenveen (Friesland, NL) and TEC, PBM, Corbion will be involved. - IT HUB chemical technology upscaling to TRL 7. NOVAMONT technology will be used to recycle 600 kg of mixed composites including Mater-Bi. Also PHA from the NL and ES Hub will be tested in the IT HUB to blend into further Mater-Bi bioplastic formulations. IREN Group waste sorting site of Borgaro Torinese (Piedmont, Italy) and NOVAMONT’s new dedicated bioplastics recycling section within its Terni (IT) plant will be involved. - ES HUB Enzymatic recycling technology brought to TRL 6 , producing 50 kg within reactors of 200 litre s (CSIC (supported by AIMPLAS pre-treatment). Microbial recycling technology (by the AD “short-circuited” technology of GPB and UCD via pure culture fermentation ) brought to TRL 7 resulting outcomes 100kg rPHA (PHBV & PHBHx) and 20 kg rPHBV. Mechanical Technology upscaling to TRL 7 with the KPI level to be achieved 250 kg bioplastic recycle (TCD, AIMPLAS involved). HUB activities in SAV waste sorting site of Manises (Valencia, Spain). ReBioCycle will verify the industrial grade specifications by biopolymer brand owners and via demonstration of real-world products: durable (ARAPAHA: PLA) and multi-use packaging (SULAPAC: PHA and Mater-Bi). The LCA analysis by ARCHA and tailored D&E plan by partners EUBP and MAGFI will facilitate KER uptake.

Keywords: portfolio of sorting and recycling technologies for pla,pha,pef and mixed bioplastic composites,such as mater bi
Forecasting and observing the open-to-coastal ocean for Copernicus users (FOCCUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Germany,France,Italy,Spain,Netherlands,Norway,Sweden,Portugal,Belgium,Romania,Denmark
Call: Copernicus for Marine Environment Monitoring (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 5304227.05
EU funding (EUR): 4999655.62
Participants: 19
Project status: SIGNED

The main ambition of FOCCUS is to improve and advance the coastal dimension of the Copernicus Marine Environment Monitoring Service (CMEMS) by enhancing existing capability, developing innovative coastal products. Designing and demonstrating the integration of Copernicus and Member State coastal services will allow a seamless and fit-for-use monitoring and forecasting of the ocean from global to regional and coastal scales. Co-production of coastal services will reinforce the quality, efficiency and exploitation of Copernicus research and specific applications will demonstrate FOCCUS’s progress beyond the state of the art for challenges such as the protection of the coastal zone, the development of a sustainable blue economy, and the building of coastal zone resilience to climate change, anthropogenic pressures and natural hazards. At the heart of the proposed methodology is the use of new space (such as Sentinels) and in-situ coastal observations, innovations in data fusion, data processing and visualisation together with seamless numerical coastal prediction (including interfaces for downscaling from CMEMS) from the regional to the near-shore, also connecting to the estuarine scale. Novel approaches will be used to ensure CMEMS evolves at the forefront of modern research and technology, in-line with the innovation and digitalisation required for the European digital ocean and water knowledge system. FOCCUS will ensure credible pathways for effective uptake and exploitation of key outcomes and research results by the CMEMS and the wider user community, thereby fostering the acceptance and efficient application of novel information products by society. This will include demonstrations of the technical readiness of the proposed evolutions and active dialogue with European and international initiatives to ensure the global community is aware of FOCCUS, and that results contribute to wider efforts.

Keywords: copernicus marine coastal dimension new coastal products,sentinel data,seamless and fit for use forecasting member states coastal systems,sustainable blue economy
Numerical Investigation of Two-Phase flows for ORC applications (NI2PhORC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-10-31
Duration (months): 26.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

With this proposal I aim to develop an accurate and robust numerical tool for the simulation of compressible two-phase flows for Organic Rankine Cycle (ORC) applications. Recent studies have shown that the power output of ORC systems may be increased up to 30% by implementing a wet-to-dry turbine expansion, which starts in the two-phase regime and ends in the dry vapor. Advanced numerical tools are required to confirm these predictions, and to investigate more accurately these flows. To ensure an adequate level of reliability, I propose to develop a numerical tool based on the non-equilibrium Baer and Nunziato (BN)-type model. The suggested model naturally takes into account non-instantaneous mass and heat transfer. By using an adaptive strategy based on non-standard criteria to predict the local flow topology, the model will also be able to deal with the different flow topologies that occur in a wet-to-dry expansion. Finally, the effects of the finite relaxation scales will be investigated through a parametric study, and specific empirical indications for two-phase ORC systems will be delivered to the community involved in their optimization and design. The developed simulation software will be released under an open-source policy within the SU2 simulation toolkit, a choice that will help engineers solve transient two-phase fluid dynamics problems. The ensuing availability of an adaptive diffuse interface method will also contribute to answer the need for advanced numerical methods able to effectively deal with the multiscale nature of two-phase flows. The inter-disciplinary character of the NI2PhORC project, which blends techniques of fluid dynamics, applied mathematics, and scientific computing, represents an invaluable opportunity for me to develop a solid and comprehensive scientific background to advance my scientific career within an engineering department.

Keywords: non equilibrium two phase flows non ideal compressible fluid dynamics mass and heat transfer orc applications thermochemical relaxation