Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards Next-generation Eco-efficient PHOTO and EMULSION Polymerisations Imparting Synergy to Process, Products and Applications (PHOTO-EMULSION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany,Germany,Spain,Germany,Germany,Ireland,Slovenia,Poland,Sweden,France,France
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-10-01
End date: 2022-01-31
Duration (months): 52.0
Total project cost (EUR): 2012205.24
EU funding (EUR): 2012205.24
Participants: 13
Project status: CLOSED

The polymer industry is going through one of the most significant periods of change in its history. Driven by new environmental regulations, the development of eco-efficient processes and zero-VOC products has become an absolute necessity. In this field, 2 technologies stand out: Polymerisation in dispersed media and Photopolymerisation. To maintain EU leadership in this sector, PHOTO-EMULSION aims at training a creative, entrepreneurial & innovative next-generation of 8 Early-Stage Researchers (ESRs) who can push towards new eco-friendly polymerisation processes. Our primary strength is a demanding technical knowledge base bringing together, for the first time, all disciplines related to these 2 strategic fields. Secondly, we will broaden traditional doctoral training by targeting transferable and specialized skills sought after by the employers, and learned through innovative methods: tandem ESRs, distance language learning, ESR as itinerant science educator, online courses, ESR-led subproject, highly interactive meetings, and industrial secondments. In research, we will develop a “hybrid” next-generation technology based on thiol-ene photopolymerisation in dispersed media. Advanced manufacturing based on photoreactor promises a wave of high sulfur content dispersed products (films, nanoparticles, porous network). Their outstanding properties open the door to applications responding to current Industral needs such as non-leaching materials, O2 barrier and biobased waterborne coatings, biologically-active particles, hybrid nanosensors and monolithic chromatography column. PHOTO-EMULSION involves a high-quality research network including 8 internationally reputed academic institutions, 4 leading companies and 2 non-profit organisations. Balanced & EU-wide, our diversity expresses through the participation of 8 countries (Austria, France, Germany, Ireland, Poland, Slovenia, Sweden & Spain), 50% female scientists-in-charge, and structures supporting gender equality.

Keywords: photopolymerization,emulsion polymerization,green chemistry,sulfur,uv light
Development and use of an integrated in silico-in vitro mesofluidics system for tissue engineering (INSITE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium,Belgium
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 2161750.0
EU funding (EUR): 1435375.0
Participants: 2
Project status: SIGNED

Tissue Engineering (TE) refers to the branch of medicine that aims to replace or regenerate functional tissue or organs using man-made living implants. As the field is moving towards more complex TE constructs with sophisticated functionalities, there is a lack of dedicated in vitro devices that allow testing the response of the complex construct as a whole, prior to implantation. Additionally, the knowledge accumulated from mechanistic and empirical in vitro and in vivo studies is often underused in the development of novel constructs due to a lack of integration of all the data in a single, in silico, platform. The INSITE project aims to address both challenges by developing a new mesofluidics set-up for in vitro testing of TE constructs and by developing dedicated multiscale and multiphysics models that aggregate the available data and use these to design complex constructs and proper mesofluidics settings for in vitro testing. The combination of these in silico and in vitro approaches will lead to an integrated knowledge-rich mesofluidics system that provides an in vivo-like time-varying in vitro environment. The system will emulate the in vivo environment present at the (early) stages of bone regeneration including the vascularization process and the innate immune response. A proof of concept will be delivered for complex TE constructs for large bone defects and infected fractures. To realize this project, the applicant can draw on her well-published track record and extensive network in the fields of in silico medicine and skeletal TE. If successful, INSITE will generate a shift from in vivo to in vitro work and hence a transformation of the classical R&D pipeline. Using this system will allow for a maximum of relevant in vitro research prior to the in vivo phase, which is highly needed in academia and industry with the increasing ethical (3R), financial and regulatory constraints.

Keywords: in silico modeling,computational modeling,tissue engineering,mesofluidics,in vitro,bioprocess engineering,systems biology,bone regeneration
Keelcrab the Drone for an automated hull cleaning: fast & essential (Keelcrab)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The underwater drone KeelCrab SailOne is the first R.O.V vehicle for the care of your hull entirely designed and built in Italy. Fast, lightweight, practical, user friendly, you can easily reduce the consumption of your boat keeping your hull in a perfect state with top performance. KeelCrab will contribute to stop usage of polluting antifouling paints and open the way for green solutions with a safe respect for the environment and your wallet.

Keywords: hull cleaning,underwater drone,sailing performance,keel,hull,inspection,hull cleaning tecnhology,fouling prevention,nautic innovation
EU routes for High pEnentration of solaR PV into lOcal nEtworkS (EU HEROES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Germany,Spain,Poland,Greece,Lithuania,Netherlands,United Kingdom
Call: Market uptake of renewable energy technologies (H2020-LCE-2017-RES-CSA, 2017)
Start date: 2017-09-01
End date: 2020-08-31
Duration (months): 36.0
Total project cost (EUR): 1230557.5
EU funding (EUR): 1230557.5
Participants: 7
Project status: CLOSED

The overall aim of the project is to enable the continued development of community-owned PV by developing viable business models that address the concerns of network operators. The project will work with communities and network operators to develop approaches that will enable subsidy-free solar PV projects that have a neutral or positive impact on network management. The project will: 1. Identify and develop social enterprise models that enable increased deployment of solar PV in grid-constrained areas. 2. Carry out cost-benefit analysis and economic feasibility assessment and develop business models that enable community groups to store, utilise, aggregate and trade solar electricity within localities as well as simply exporting excess energy to the grid. 3. Empower citizens to have greater ownership over their energy supply, through removing key barriers to community PV, democratising energy and recycling profits from energy generation into host communities.

Keywords: community solar,high pentration pv,grid integration,sustainable business models beyond net metering,new solar market segments
Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients (MyNano)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1724168.97
EU funding (EUR): 1724168.97
Participants: 1
Project status: CLOSED

Research on anticancer therapies has provided little progress towards improved survival rates for patients with metastatic disease. The intrinsic advantages of polymer conjugates can be optimised to rationally design targeted combination therapies, concept I pioneered that allows enhanced therapeutic efficiency. Early clinical trials involving conjugates showed activity in chemotherapy refractory patients and reduced drug-related toxicity. However, there is a growing concern on patient variability regarding tumor patho-physiology that underlie successful therapeutic outcome. Specific biomarkers are required to select those patients most likely to show good clinical response to these therapies. The objective of MyNano is to engineer polymer-based combination therapies designed to treat metastatic breast cancer in a patient personalised manner. Therefore, novel multicomponent polymer conjugates with precise control over size, shape, solution conformation, multifunctionality and bioresponsiveness will be obtained while in parallel their structure activity relationships to underlying proposed mechanisms of action in clinically relevant models will be studied. Polyglutamates obtained by controlled polymerisation and self-assembly strategies will be the carriers. Primary breast cancer patient tissue will be used to generate cell and in vivo models representing different clinical molecular subtypes. MyNano will also investigate new combination strategies using current treatments together with inhibitors of tumor-derived exosome release pathways, phenomenon related to metastasis and resistance mechanisms. The aim is to provide a novel methodological approach that would allow by reiterative design to optimise the design of the next generation nanoconjugates for the treatment of specific metastatic cancer clinical subtypes. MyNano will be a breakthrough as it introduces a paradigm shift in the strategy to design nanomedicines in areas of unmet clinical need.

Keywords: polymer therapeutics,nanomedicine,targeted drug delivery,structure activity relationships
Multidisciplinary and multi-context demonstration of EGS exploration and Exploitation Techniques and potentials (MEET)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Germany,Iceland,Germany,Germany,Croatia,Belgium,France,France,France,France,France,France,France,France,France
Call: EGS in different geological conditions (H2020-LCE-2017-RES-IA, 2017)
Start date: 2018-05-01
End date: 2022-10-31
Duration (months): 54.0
Total project cost (EUR): 11720348.39
EU funding (EUR): 9972818.879999999
Participants: 19
Project status: SIGNED

The main objective of MEET is to capitalize on the exploitation of the widest range of fluid temperature in EGS (Enhanced geothermal systems) plants and abandoned oil wells. The aim is to demonstrate the lower cost of small-scale production of electricity and heat in wider areas with various geological environments, in order to support a large increase of geothermal-based production sites in Europe in a near future. In order to boost the market penetration of geothermal power in Europe, MEET project main goal is to demonstrate the viability and sustainability of EGS with electric and thermal power generation in all kinds of geological settings with four main types of rocks: granitic (igneous intrusive), volcanic, sedimentary and metamorphic with various degrees of tectonic overprint by faulting and folding. MEET brings together 16 European partners: Industrials, small and medium enterprises, research institutes and universities, but also several geothermal demonstration sites in Europe located in the various geological environments described above. The project aims at the optimization of the reservoir productivity and stimulation techniques, taking advantage of the existing infrastructures, the understanding of the various geological contexts, necessary to transfer the current known EGS technology to other typical basement rock situations in Europe, the demonstration and optimization of electric and thermal power generation in different geological settings. The assessment of the technical, economic and environmental feasibility of EGS is an integral part of the project, as well as the mapping of the main promising European sites where EGS can or should be implemented in a near future. Thus, MEET will provide a roadmap of next promising sites where demonstrated EGS solutions could be replicated in a near future for electricity and heat production with an evaluation of the technology and its economic feasibility and environmental positive impacts.

Keywords: enhanced geothermal systems,heat,electricity production,stimulation,corrosion,upscaling,egs mapping
iManageCancer - Empowering patients and strengthening self-management in cancer diseases (iManageCancer)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Greece,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Self management of health and disease: citizen engagement and mHealth (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-02-01
End date: 2018-07-31
Duration (months): 42.0
Total project cost (EUR): 4856174.0
EU funding (EUR): 4856174.0
Participants: 11
Project status: CLOSED

Chronic cancer treatment places new demands on patients and families to manage their own care. The iManageCancer project will support this challenge and provide a cancer disease self-management platform designed according to the specific needs of patient groups and focusing on the wellbeing of the cancer patient with special emphasis on psycho-emotional evaluation and self-motivated goals. The platform will be centred in a Personal Health Record that will exploit recent advances on Health Avatars for the individual cancer patient surrounded by mHealth applications designed to encourage the patient, enhance clinician-patient communication, maximise compliance to therapy, inform about drug interactions, and contribute to the management of pain and other side-effects of cancer treatment. The Health Avatar PHR will regularly monitor the psycho-emotional status of the patient and will periodically record the everyday life experiences of the cancer patient with respect to the therapy side effects, while different groups of patients and their families will share information through diaries and clinicians are provided with clinical information. The PHR will help assess adherence to therapy, physiological and psychological status while the platform will recommend targeted informative applications and serious games according to the disease type and psycho-emotional status of the patients in order to promote a positive and healthier psycho-emotional state. The disease management platform will be further complemented by an integrated expert system with formal self-management models that will be oriented to decision support, the management of side-effects, adherence to therapy and guidance for patients including drug dose self-adjustments. The iManageCancer platform will be designed on clinical evidence and in close collaboration of clinical experts, IT specialists and patients and will be assessed in clinical pilots with adult and paediatric cancer patients.

Keywords: patient empowerment,mhealth,self management,personal health systems,serious games,decision support,disease management
Repurposing clinically approved antibacterial drugs for treponematoses therapy (Trep-AB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain,United States
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1498790.0
EU funding (EUR): 1150678.81
Participants: 2
Project status: SIGNED

Current therapeutic options for human treponematoses, syphilis and yaws, are, broadly speaking, restricted to one antibiotic: injectable penicillin. The drug susceptibility profile of Treponema pallidum (T.p) is unknown because the microorganism could not be grown in culture. Treatment failure after penicillin has been related to syphilis bacteria that survive in the central nervous system (CNS) and the potential of strains to acquire resistance to penicillin has recently been recognized. Yaws can be treated with azithromycin but there is a real risk that macrolide-resistant strains disseminate widely and jeopardize the global eradication campaign. I propose a research program to have other validated treatment options with good CNS penetration that are efficacious for all the stages of treponemal infection. Our preliminary results using computational prediction of drug activity based on similarity to drugs with known activity against T.p. and other spirochetes shows several candidate antibiotics. I will take advantage of recent developments in culture methods for determination of drug susceptibility to test 20 prioritized drugs. These results will be confirmed in experimentally infected rabbits treated with the investigational drugs and assessed for lesion development and T.p. burden. My second approach will exploit the established expertise of my team conducting randomized clinical trials to evaluate the efficacy of the 2 most promising candidates compared to standard treatment to cure patients with syphilis/yaws. Such studies will incorporate in-depth studies of recurrent events among study participants, to further clarify the biological basis and identify mutations that confer resistance to B-lactams. New antibacterial oral drugs for the treatment of treponematoses will be a tremendous resource in case of penicillin treatment-failure, resistance, shortage, allergy, or for use in yaws combination regimens to reduce the likelihood of resistance selection.

Keywords: syphilis animal model,difficult clinical management in syphilis,antimicrobial equivalence trial in syphilis,syphilis whole genome sequencing,mass azithromycin treatment of yaws
Graphene Flagship Core Project 2 (GrapheneCore2)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Graphene Flagship
Action type: Specific Grant agreement
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Spain,Estonia,Ireland,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Israel,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Ireland,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Spain,Spain,Italy,Italy,Italy,Austria,Germany,Spain,Spain,Italy,Italy,Italy,Switzerland,Switzerland,Switzerland,Switzerland,Switzerland,Belgium,Belgium,Finland,Greece,Greece,Poland,Sweden,Sweden,Switzerland,Belgium,Sweden,Sweden,Belgium,Bulgaria,Hungary,Norway,Sweden,France,France,France,France,France,France,France,France,France,France,France,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Graphene FET Flagship core project (H2020-SGA-FET-GRAPHENE-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 88000000.0
EU funding (EUR): 88000000.0
Participants: 215
Project status: CLOSED

This proposal describes the third stage of the EC-funded part of the Graphene Flagship. It builds upon the results achieved in the ramp-up phase (2013 - 2016) and the first core project (2016 - 2018), and covers the period April 2018 - March 2020. The progress of the flagship follows the general plans set out in the Framework Partnership Agreement, and the second core project represents an additional step towards higher technology and manufacturing readiness levels. The Flagship is built upon the concept of value chains, one of which is along the axis of materials-components-systems; the ramp-up phase placed substantial resources on the development of materials production technologies, the first core project moved to emphasise components, and the second core project will move further towards integrating components in larger systems. This evolution is manifested, e.g., in the introduction of six market-motivated spearhead projects during the Core 2 project.

Keywords: graphene,composite materials,energy applications,electronics,photonics,sensors,biomedical technologies,basic research
Supporting smart financing implementation for energy efficient Balkan Buildings (SMAFIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Greece,Romania,Croatia,Bulgaria,Greece
Call: National roundtables to implement the Smart Finance for Smart Buildings initiative (H2020-LC-SC3-EE-2020-1, 2020)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 695206.25
EU funding (EUR): 695206.25
Participants: 7
Project status: SIGNED

The overall aim of this proposal is to set up permanent discussion forums on energy efficiency investment topics gathering government, local and regional authorities, financial sector, ESCOs, homeowners, industry sector, construction sector and SME sector. The focus of the roundtables should include existing private and public buildings, industry and SME’s. The forums will gather and upscale existing best practices from the national and European level, develop strategies, and action plans, propose improvements in the national policy frameworks and measures, and follow their implementation, develop jointly template documents and contracts leading to a better functioning of the market. The roundtables will act as a forum where all stakeholders can learn from successful market initiatives, and can provide input into the policy making process

Keywords: energy efficiency,buildings,roundtables,financi