Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SYMBIONICA - Reconfigurable Machine for the new Additive and Subtractive Manufacturing of next generation fully personalized bionics and smart prosthetics (Symbionica)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Italy,Switzerland,Greece,United Kingdom,United Kingdom
Call: Manufacturing of custom made parts for personalised products (H2020-FoF-2015, 2015)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 7305000.0
EU funding (EUR): 4908750.0
Participants: 12
Project status: CLOSED

Medtech products belongs to a huge expanding market, in which Europe hosts some of the biggest global player, accounting for 30% of the world market and for more than 575,000 people employed by nearly 25,000 medical technology companies – 95% of which are SMEs. Symbionica project focuses on the manufacturing of personalized bionics, smart endoprosthetics and exo-prosthetics that require geometric and functional customization. The Symbionica concept integrates an innovative machine performing deposition of advanced materials and subtractive processes along with a supply chain distributed co-engineering platform for advanced design and full personalization involving all relevant stakeholders, design and engineering of the products and through-life services. Symbionica manufacturing solution is conceived as a multi-material AM machine for material deposition and ablation, flexible and reconfigurable in the working cube, the material processing, the technology and the manufacturing strategy, with an advanced closed loop control methodology for product and process quality monitoring. This way Symbionica products are manufactured in one processing step, complex in shape, 3D structured and joint free. The Cooperative Design Platform will guarantee seamless data integration, reverse engineering from patient and parametric design to couple patient specific parts to standard ones. At the end, a Bionic Through-life Sensing System will support the patient to approach and gradually become comfortable with the prosthesis by assisting him with an exercise plan, a physiology monitoring platform and an on-line prosthesis data collection. The Symbionica consortium involves 3 LE, 6 SME and 2 RTD partners from 5 EU countries embracing the Medtech value chain from the patient and prosthetist to the technology providers of the mechatronics modules, IT solutions and control platforms.

Keywords: personalized bionics and smart prosthetics,additive and subtractive manufacturing,reconfigurable machines,medtech effective value chain
FACCE-Evolve - Agriculture, Food Security and Climate Change Coordination and Support Action 2 (FACCE-Evolve)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Coordination and support actions
Countries involved: Germany,Italy,Germany,Spain,Finland,Romania,France,Netherlands,Denmark,United Kingdom
Call: Coordination action in support of the implementation by participating States of a Joint Programming Initiative on Agriculture, Food Security and Climate Change (H2020-ISIB-2014-1, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 3328035.92
EU funding (EUR): 2000000.0
Participants: 11
Project status: CLOSED

The Joint Programming Initiative on Agriculture, Food Security and Climate Change (FACCE-JPI), launched in October 2010 by the European Council, brings together 21 countries committed to “building an integrated European Research Area addressing the challenges of agriculture, food security and climate change” (FACCE-JPI Strategic Research Agenda). The JPI aims at aligning research programming among its members in the long run, so as to increase the efficiency of research funding, cover gaps, avoid duplications and provide high-level innovative research on the European scene. The FACCE-Evolve Coordination and Support Action is designed to solidify foundations that will ensure long-term durability of joint programming and actions. FACCE-Evolve will thus continue to support the successful development of the FACCE-JPI and allow it to develop a set of means destined to ensure its self-sustainability. The FACCE-Evolve will therefore provide support to JPI members in order to: • Investigate different options for self-sustainability and test the most suitable ones. • Investigate and develop novel processes and tools to support uptake of the SRA and its updates as well as the bi-annual implementation plans and monitor effective harmonisation, integration and alignment of national research programming, to enable evidence-based policy making and effective cross-policy actions • Implement and oversee the increasing number of joint actions • Pursue ongoing coordination with Horizon 2020 objectives with a scale and scope of action that should go well beyond what either the EU or Member States can achieve on their own • Ensure the perpetuation of an effective, enriching dialogue with European and international stakeholders • Strengthen the international dimension and visibility of the JPI through a strong communication and dissemination strategy and links with other initiatives.

Keywords: strategic research agenda,implementation plan,self sustainability,agriculture,food security,climate change
Geometry of Nonnegative Rank (NonnegativeRank)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 166603.2
EU funding (EUR): 166603.2
Participants: 3
Project status: CLOSED

This proposal is centered on nonnegative rank - a notion that modifies the definition of matrix rank. This project is basic research aimed to better understand the geometry of matrices and tensors of nonnegative rank at most r, how this knowledge can be employed to improve exact and numerical nonnegative matrix algorithms, obtain an algorithm for nested polytopes in dimension three, and address questions about mixture models in statistics. Computing and understanding nonnegative rank is truly interdisciplinary. Completing this project requires techniques from polyhedral geometry, real algebraic geometry, optimization, statistics, symbolic algebra, and numerics.

Keywords: nonnegative rank,applied algebraic geometry,algebraic statistics,real algebraic geometry,algebraic boundary,polytopes,zero patterns,maximum likelihood estimation,em algorithm
Effort and Social Inequality: Advancing Measurement and Understanding Parental Origin Effects (EFFORT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Spain,Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-02-29
Duration (months): 72.0
Total project cost (EUR): 1499572.0
EU funding (EUR): 1227359.5
Participants: 3
Project status: SIGNED

This project aims to understand the role of effort in the reproduction of social inequality. While large-scale test programs like PISA have produced impressive amounts of data on the determinants of cognitive abilities, there is scant evidence on socio-economic differences in cognitive effort. Better understanding the social origins of effort pushes the frontier of knowledge on intergenerational mobility and allows improving equality of opportunity. Specifically, the aim of the project is to answer three research questions: 1. To what extent do children’s effort levels differ by parental socioeconomic background? (descriptive component) 2. Can existing disparities in effort by social background be explained by (a) the intergenerational transmission of effort from parents to children, and (b) varying motivations and differential susceptibility to incentives? (analytical component) 3. What are the best techniques to measure cognitive effort and what are the strengths and weaknesses of measures routinely used in different scientific disciplines? (methodological component) The project will develop and exploit cutting-edge methods of effort measurement such as real-effort tasks and psychophysiological techniques like pupillometry. Their immense potential has remained untapped in inequality research thus far. Experimental data will be collected for a large sample of school-age children and their parents in Spain and Germany. Subjective effort dispositions will be further analyzed using (inter)national surveys. The triangulation of carefully chosen methodologies will provide the first reliable evidence on socioeconomic differences in effort and stimulate new research (e.g. on gender or ethnic differentials in effort). Cross-validation analysis will detect possible biases of commonly used effort measures. The research findings will provide valuable insights for educational practitioners and decisive evidence for normative debates about social inequality and policy design.

Keywords: equality of opportunity,measurement,learning
Long-retention liposomic drug-delivery for intra-articular osteoarthritis therapy (OAlipotherapy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-07-01
End date: 2019-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Osteoarthritis (OA) is the most widespread joint disease, affecting millions and imposing a huge individual and socio-economic burden. The creation of liposomes functionalised with novel (IP-protected) molecules that greatly extend (by almost an order of magnitude) their half-life in joints following IA injection, relative to existing approaches, and the alleviation of OA that may arise through exploiting this longer retention, is the basis of this proof of concept project. The main innovation step is functionalizing liposomes with our novel molecules to provide much longer retention drug-delivery vehicles, which therefore provide greater benefits in therapy relative to existing approaches, and so should be preferred by patients. Its practical implementation, to advance and investigate the potential for long-retention IA drug-delivery and other uses, will be carried out both through validation on animals (proof-of-concept), through suitable pre-commercialisation studies, networking and identifying potential partners, and developing a business plan. Hence, we propose to validate the concept of creating new products that will be available commercially for IA delivery, implementing the long-retention in the joints which greatly enhances their usefulness and which is the basis of the present innovation step.

Keywords: liposomic drug delivery vehicles,intra articular injection,retention time
Soft and Tangible Organic Responsive Materials progressing roBOTic functionS (STORM-BOTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Italy,Germany,Spain,Finland,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2025-01-31
Duration (months): 49.0
Total project cost (EUR): 3459886.2
EU funding (EUR): 3459886.2
Participants: 10
Project status: SIGNED

Soft responsive materials and new fabrication schemes are key ingredients to develop new disruptive technologies for robotic elements and devices. Such devices are anticipated to revolutionize the fields of minimally invasive surgery, targeted drug delivery, material sampling and manipulation, responsive functional surfaces and human-machine interfaces. The use of soft responsive, instead of hard inert, matter in these areas provides unique features such as the material being able to sense the environment and autonomously perform complex tasks – “the material is the machine”. In this scenario, liquid crystal elastomers are receiving an increasing deal of attention as they exhibit large, programmable mechanical deformations in response to different stimuli. Europe has played a leading role in liquid crystal science since its birth. To be at the forefront also tomorrow, we aim at harnessing the full potential of liquid-crystal-based responsive surfaces, soft actuators and smart machines. Encompassing aspects from chemistry, physics, materials science, advanced manufacturing and robotics, we will train 13 science-educated and engineering-minded young pioneers to advance the state of the art of this exciting research field. STORM-BOTS will count on academic and non-academic leaders from top research institutions and with unique scientific and technical expertise, in order to provide the next generation of scientists and engineers the best possible research environment for developing new materials and manufacturing tools to enable advanced robotic functions. Based on innovative individual research projects, STORM-BOTS will provide the students with a transnational, comprehensive, highly integrated, multidisciplinary and multi-sectoral training programme. Through local and network-wide training activities, the students will learn the many faces of this cutting-edge research area, as well as a variety of relevant transferable skills needed for their future careers.

Keywords: liquid crystal elastomers,responsive polymers,additive manufacturing,soft actuators,soft robotics,computational engineering
International Cooperation on Quantum Technologies (InCoQFlag)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Tackling grand interdisciplinary science and technology challenges
Action type: Coordination and support actions
Countries involved: Spain,Poland,France,Netherlands
Call: International Cooperation on Quantum Technologies (H2020-FETFLAG-2020-01, 2020)
Start date: 2020-09-01
End date: 2024-02-29
Duration (months): 42.0
Total project cost (EUR): 592400.0
EU funding (EUR): 592400.0
Participants: 4
Project status: SIGNED

International competition in Quantum Technologies has become a major challenge in the recent years. Europe has world-leading researchers in all Quantum Science areas: Communication; Sensing; Metrology; Computing; and, Simulation. However, it would be unrealistic to maintain such a strong position without considering the worldwide battle of communication launched by private and public companies on quantum technologies. To take advantage of such international competition, the InCoQFlag project proposes to provide a roadmap to international partnerships, which can be used by the EU to set up winning partnerships with countries that are massively investing in Quantum Science and Technologies. This would strengthen Europe’s position at an upper level, avoid brain drain and favour IP protection to support Member States’ economic growth. Within the InCoQFlag project, we will assess quantum standardization, infrastructures and IP protection issues. Furthermore, the necessity of an innovative framework to take advantage of Quantum Technologies is assessed by a global policy. Most of the InCoQFlag members are involved in the Flagship coordination and support action. Hence, they will benefit from their experience in the QFlag project to elaborate new actions related to International Collaborations in the scope of targeted countries efficiently. These targeted countries are the USA, Japan and Canada. To this end, InCoQFlag will ensure a smooth communication and coordination between both CSA projects in order to maximize their impact and favour European academic and public/private research organisations with their top-level counterparts outside Europe.

Keywords: quantum technologies,roadmap,win win collaborations,competencies,recommendations,international cooperation,japan,canada,europe
DeVelopment of a Universal seLeCtive stripping solution for Aircraft coatiNgs (VULCAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France
Call: Development of an eco-friendly selective stripping for exterior surfaces of airframe structures (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2022-10-31
Duration (months): 48.0
Total project cost (EUR): 554921.25
EU funding (EUR): 554920.0
Participants: 2
Project status: CLOSED

The VULCAN project aims to develop an innovative dry selective stripping process using laser shock for airframe surfaces. The process will allow a layer by layer stripping on metallic and composite substrates thanks to a fine tuning of process parameters. The VULCAN project objective is to go beyond traditional laser IR or UV stripping using laser shock in order to fulfill all requirement of aerospace industry that are: • Development of a dry stripping process • Environmental friendliness: no use of chemicals and liquid solutions, reduction of production of hazardous wastes, no water consumption, limited worker exposure to toxic and hazardous substances, reduction of hazardous material disposal costs • Universal solution that can be applied on metallic and composite substrates • Selective = controlled stripping of a thin layer without affecting the surface treatment or the prime - For metals = corrosion protection stays intact, for composites = no top coat or fibers damages - No deformation or any kind of damage - Automated for productivity benefits (cost effective, reproductibility, efficient speed The consortium is composed of 2 partners who have a long track record in laser technology, coating development and aerospace materials testings.

Keywords: laser,selective stripping,metals,composites
The Homeostatic Regulation and Biological Function of Sleep (Somnostat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2374999.0
EU funding (EUR): 2374999.0
Participants: 1
Project status: SIGNED

Sleep is vital and universal, but its biological function remains unknown. This project will seek to understand why we need to sleep by studying how the brain responds to sleep loss. My previous work in Drosophila showed that rising sleep pressure activates two dozen sleep-inducing neurons in the dorsal fan-shaped body (dFB) of the central complex. Sleep need is encoded in the electrical excitability of these neurons, which fluctuates because two potassium conductances, voltage-gated Shaker and the leak channel Sandman, are modulated antagonistically. As a consequence, dFB neurons are electrically silent during waking and persistently active during sleep. The key open question addressed in this project is the nature of the molecular changes that drive dFB neurons into the electrically active state. My preliminary data point to two dFB-intrinsic transducers of sleep pressure. First, the Shaker β subunit Hyperkinetic responds via a bound nicotinamide cofactor to oxidative by-products of mitochondrial electron transport, revealing a potential connection between energy metabolism, oxidative stress, and sleep, three processes implicated independently in lifespan, aging, and disease. To strengthen this connection, we will monitor sleep and the biophysics of dFB neurons after perturbing mitochondrial respiration or cellular redox chemistry and vice versa. Second, Rho GTPases relay currently unknown signals to the machinery responsible for the regulated endocytosis of Sandman, whose extraction from the plasma membrane is a prerequisite for switching the sleep-promoting activity of dFB neurons on. To identify these signals, we will investigate cell-autonomous, synaptic, and non-synaptic mechanisms of GTPase control. Because clear parallels exist between dFB neurons and sleep-active neurons in the mammalian hypothalamus, mechanistic insights that can currently be gained only in Drosophila are expected to have broad validity for understanding sleep and its disruptions.

Keywords: sleep,sleep homeostasis,potassium channel,mitochondria,neuronal circuits,drosophila melanogaster