Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improving community Resilience through Experimentally validated tools for assessing the performance of Structures under Earthquake and Tsunami hazards (iRESET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-01
End date: 2025-06-01
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Several coastal communities across Europe and the entire globe are exposed to earthquake triggered tsunami hazards. Past EU projects on the tsunami risk assessment highlighted the significant gaps in existing knowledge in the relatively new tsunami engineering field regarding the fragility of buildings and critical infrastructures to such hazards. The iRESET project looks at filling the gaps in fundamental knowledge about the physical behaviour of buildings hit by tsunami flows and by sequential earthquakes and tsunami (E&T). iRESET is conceived in a multi-hazard vision, combining load-histories from hydraulic tests with an innovative quasi-static structural testing procedure (with novel test set-up and load protocols) able to simulate the tsunami-induced loads on large-scale sub-structures and to experimentally investigate the performance of structures under sequential earthquake and tsunami loads. The project covers aspects of multi-hazard risk assessment, fluid dynamics and civil/structural/coastal engineering. Furthermore, the proposed new testing methodology is highly transversal and could be adopted for other natural hazards such as floods, slow landslides and storm surges, representing a unique experimental resource for the EU. This proposal includes a strong two-way transfer of knowledge between the experienced researcher (ER) and the host institution, a wide dissemination plan and will have a strong impact on the ER future academic career, giving the chance to achieve a strategic position among the international scientific community, becoming a leading expert in the tsunami engineering field in Europe and worldwide. The results will contribute to an improved European capacity for the assessment and management of tsunami and E&T risk. This is in line with the EU policy priorities focusing on creating a resilient and stable society against disasters toward a successful implementation of the Sendai Framework for Disaster Risk Reduction 2015-2030.

Keywords: tsunami engineering,structural capacity assessment,quasi static experimental testing,risk assessment,cascading events
Human Lung Microbiota And Innate Immunity (HUMANITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-25
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Human lung microbiota research is in its infancy, but has already provided compelling evidence that lung bacteria have key roles in human health. However, how lung bacteria interact with the host immune system and influence lung health is poorly understood. I am an infection biologist and immunologist who carried out his PhD on the human pathogen Staphylococcus aureus. I now aim to investigate the cross-talk between resident lung bacteria and the host immune system. I will focus on the lung microbiota of transplant patients, because different bacterial communities have been associated with different immune states in transplanted lungs indicating that microbiota-host interactions are vital for allograft health. My specific objectives are to (i) establish the first culture collection of primary lung bacterial isolates, (ii) characterize their cross-talk with the immune system, and (iii) analyse underlying mechanisms through a combination of bacterial culturing, cell culture and mouse infection experiments, immune system transcriptomics, comparative genome analysis, and metabolomics. This multidisciplinary approach will be conducted with two research groups at University of Lausanne (Prof. P. Engel and Prof. B. Marsland), which provide a unique scientific environment to carry out this project. None of the proposed objectives has previously been addressed. Thus, the project will provide many novel insights relevant for both basic and applied sciences. I will be able to apply my profound knowledge in infection disease and immunology to an emerging field of microbiota research and transfer my expertise to the host groups. In turn, I will expand my scientific breadth by learning advanced concepts of microbial ecology, acquiring methodological skills in community analysis, genomics, transcriptomics, and metabolomics, and obtaining training in project management and science communication. I envision that this project will present the basis for my future research career.

Keywords: human microbiota,lung microbiota,microbial diversity,immunology,macrophages,innate immunity,high throughput sequencing,nanostring,gene expression,transcriptomics,mouse models
Development of a High Voltage Lithium BATtery (LiBAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany
Call: Development of a High Voltage Lithium Battery (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 584225.0
EU funding (EUR): 584225.0
Participants: 2
Project status: CLOSED

Hybrid and electric propulsion systems for aeronautics represent an enormous potential for innovation, especially with regard to CO2 savings. In order to achieve a reliable, efficient and safe operation of such battery systems, they must be optimized in terms of energy storage capacity, electrical power, total mass and volume, Thermal requirements for materials and construction. The main goal is to design and assemble a prototype of a entire battery pack with state-of-the-art energy density. A clear definition of the interfaces will insure the easy integration of the demonstrator into current aircraft architectures. The prototype will be developed to reach TRL4 and will be validated in laboratory conditions.

Keywords: lithium battery,high voltage
Practical Autonomous Cyberhealth for resilient SMEs & Microenterprises (PALANTIR)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Germany,Spain,Cyprus,Greece,Greece,Greece,Slovenia,United Kingdom,Luxembourg
Call: Digital Security and privacy for citizens and Small and Medium Enterprises and Micro Enterprises (H2020-SU-DS-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 5194978.87
EU funding (EUR): 4046908.38
Participants: 18
Project status: SIGNED

SMEs and MEs constitute a very large part of the economy and are thus integral to the EU’s economic growth and social development. However, they often have no systematic approach for ensuring digital security and 60% of them not being able to recover economically from a cyberattack. PALANTIR aims at bridging the gap between large enterprises and SMEs/MEs, by providing multi-layered, infrastructure-wide threat monitoring, cyber-resiliency and knowledge sharing in a heterogeneous ecosystem, while at the same time being able to market these services to third parties in the form of Security-as-a-service (SECaaS). PALANTIR will implement a coherent privacy assurance, data protection, incident detection and recovery framework, focusing on the case of highly dynamic service-oriented systems and networks, taking advantage of their inherent programmability features and abstractions. PALANTIR will also focus on cyber-resiliency leveraging the features of service-oriented systems key building features by a) applying and exploiting Network Functions Virtualization (NFV) and Software-Defined Networking (SDN) technologies; b) considering emerging paradigms such as the application of scalable artificial Intelligence, standardization and threat-sharing techniques to risk analysis, network operation, monitoring and management and c) ensuring the SME’s compliance with the relevant data privacy and protection regulations in the data breach age, implementing the «Privacy by Default» and the «Privacy by Design» principles on how personal data is collected, used, transferred and stored between 3rd party businesses and entities. The end result will be an evolving, expandable and unified framework, tailored to the individual needs of every SME and ME, reducing the complexity level of usual security tools while still being affordable and thus attractive for adoption.

Keywords: risk analysis,threat intelligence,scalable artificial intelligence,software driven networks,security as a service,service oriented infrastructures,network functions virtualization
Modelling of the early agricultural spread in south of the Eastern Europe (FUZZFARM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-15
End date: 2023-03-14
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

The project aims at modeling of the early agricultural spread, the process that brought agriculture and the settled way of life to large portions of Europe in VII-V mill. BC. It is focused on the archaeological record of south of Eastern Europe and it will employ innovative way of agent based modeling based on the fuzzy sets approach. Fuzzy logic appeared extremely fruitful in modeling processes of multi-criteria decision-making. Early farmers faced various ecological, economic and social constraints in order to select a certain micro-region for colonization. These conditions will be studied in the course of the project by means of database approach for the whole south of Eastern Europe (roughly modern south-eastern Poland, Ukraine, Moldova, and eastern Romania); taking additional samples for research on paleo-soils in the three focus micro-regions which evidenced several waves of early agricultural colonization. The criteria will be formulated for a site selection by Neolithic farmers. They will be incorporated into agent-based model "Fuzzy Farmers" using a fuzzy sets approach to combine the criteria of various character in a single model (for example, type of soil needed and a need of a similar site in geographical proximity for exchange of marital partners). Agents will be represented by communities of early agriculturalists. The model will simulate the process of early agricultural expansion in actual geographic space (modelled in GIS). I plan to seek the conditions of ceasing the expansion pace and in such a way try to explain the frontiers of early farmers' spread known from archeological record of the south Eastern Europe. The archaeological record of Eastern Europe is still badly integrated into pan-European theoretical context. This process was hampered by differences in organization of science, financial background and research methodologies. The project will work towards the more general aim of building a unified European archaeology.

Keywords: early farmers,neolithization,agricultural spread,agent based modelling,fuzzy sets,paleoecology,paleosoils
E Pluribus Unum: Principles and Plasticity of Electrical Coupling in a Neuronal Network (TOGETHER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Sweden
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2222161.0
EU funding (EUR): 2222161.0
Participants: 1
Project status: SIGNED

The complex network activity patterns of the CNS result from an interplay between intrinsic neuronal properties and the connections formed by component cells. Connectivity is most commonly considered in terms of the classical chemical synapse. It is now clear, however, that electrical synapses formed by intercellular connexin channels in gap junctions (GJs) are widespread in the mammalian CNS and critically influence circuit activity. But exactly how GJs shape brain output, and how electrical coupling is regulated over different time-scales remains elusive. In the proposed project, we will take advantage of a recently discovered species difference between hypothalamic tuberoinfundibular dopamine (TIDA) neurons in the rat and mouse, to address these issues. In the rat, TIDA neurons are connected by strong GJs and exhibit a slow network oscillation; in the mouse the same cells completely lack electrical synapses and oscillate faster, a difference that ultimately leads to different male parenting phenotypes. Using the TIDA system as a platform, we will examine: I) What happens to TIDA neuronal properties and the male paternal circuit when GJs are removed from the coupled circuit, or when uncoupled cells are joined by electrical synapses? II) Does the pregnant dam prepare for motherhood by decoupling the TIDA network? III) Does electrical coupling fluctuate across neuronal oscillations? What are the mechanisms and consequences for circuit output? IV) Which organizing principles are conferred onto a network by the presence of GJs? These issues will be addressed by a combination of in vitro electrophysiology, imaging, voltammetry, behavioural paradigms and molecular analysis for a comprehensive investigation of GJ function and modulation. By leveraging the unique “experiment of nature” offered by the rodent TIDA system, the proposed project will address core issues of electrical coupling that have long remained out of reach for experimental scrutiny.

Keywords: dopamine,electrical synapse,gap junction,neuroendocrinology,neuronal network,oscillation,parental behaviour
Homologous recombination and its application in manipulating animal mitochondrial DNA (Mito-recombine)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 1473732.0
EU funding (EUR): 1473732.0
Participants: 1
Project status: SIGNED

Mitochondrial DNA (mtDNA) is a multi-copy genome that works with the nuclear genome to control energy production and various cellular processes. To date, disorders associated with mutations in mtDNA are among the most common genetically inherited metabolic diseases1. However, our knowledge regarding many aspects of mtDNA biology remains limited, and we know even less about how it influences development and organismal traits. This is largely due to our inability to manipulate mtDNA. Recently, a colleague and I developed novel genetic tools in Drosophila that allowed us to isolate animal mitochondrial mutants for the first time, and to create heteroplasmic organisms containing two mitochondrial genotypes2,3. These advances make Drosophila a powerful system for mtDNA studies. Importantly, I showed that Drosophila mtDNA could undergo homologous recombination. Furthermore, I established a system to induce recombination at specific sites and select for progeny containing only the recombinant genome4. Thus, my work has demonstrated the existence of recombination in animal mitochondria, and opens up the possibility of developing a recombination system for functional mapping and manipulating animal mtDNA. Here I propose to 1) identify components of the mitochondrial recombination machinery by a candidate RNAi screen; 2) develop a recombination toolkit to map trait-associated mtDNA sequences/SNPs; and 3) build a site-directed mutagenesis system by establishing robust ways to deliver DNA into fly mitochondria. Given the essential functions of mitochondria and their involvement in incurable diseases, the genetic tools developed in this proposal will transform the field by making it possible to link mtDNA variations to phenotypic differences and introduce specific mutations into mtDNA for functional studies at organismal level. These advances will open many possibilities to accelerate our understanding on how mtDNA impacts health, disease and evolution.
X-Europe (XEUROPE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Ireland,Hungary,Latvia,France,Netherlands,United Kingdom
Call: Startup Europe for Growth and Innovation Radar (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2022-04-30
Duration (months): 28.0
Total project cost (EUR): 1798473.21
EU funding (EUR): 1428918.75
Participants: 7
Project status: CLOSED

The X-Europe Consortium brings together leading training, acceleration, events, and media companies from across Europe. Together we will link the developing regions of the Baltics and the Visegrad region to the wider European ecosystem, rebalancing the flow of socio-economic capital. Through the delivery of training, matchmaking & promotional services X-Europe will support 150 deeptech startups and help them to internationalise, grow across borders, and into developing frontiers. The consortium has been selected carefully to ensure that each aim can be well attained. We have chosen a leading international training organisation (Growth Tribe), a strong ecosystem builder working to connect the Visegrad region through acceleration & connecting activtities (Design Terminal). Two companies (TNW & F6S) have large databases of startups, investors and job/talent communities. Finally, 2 leading international event orgnaisations in TNW and Techchill have been selected to boost the program exposure and put ecosystem connecting activities central to the programme. The programme will last 26 months and create positive feedback loops to ensure sustainable and mutually supportive impact on developing ecosystems and their deeptech beneficieries. After the completion of the project we expect higher levels of investment and partnership in developing regions and greater awareness of the opportunities and innovations available within the Visegrad and Baltic regions. X-Europe will be an iconic and flagship programme creating high levels of exposure, engagement and be a leading example on how to connect ecosystems and distribute opportunties and growth across the European Union.

Keywords: matchmaking,ecosystem building,events,training,service provision,deeptech
HIGH-VOLTAGE LITHIUM STORAGE - secure + efficient battery storage solution of the next generation (HiVOLT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 3078500.0
EU funding (EUR): 2154950.0
Participants: 1
Project status: CLOSED

The share of renewable energies such as wind and solar energy, which is fed into the electricity grids, is constantly increasing worldwide. This type of energy is highly volatile, and depending on the time of day and the weather they supply different amounts of energy. This causes two problems: 1. the energy grids are being burdened more and more - the blackout danger is growing! 2. The electricity is not available as required. That is why we need a highly flexible system in the future to compensate these fluctuations, to be able to guarantee a secure energy network and the provision of electricity on demand. Technologically, battery storages can provide this flexibility, but the price/performance ratio is still the biggest obstacle for a full market penetration. HiVOLT describes a newly developed battery system based on high-voltage technology, which offers significant cost and efficiency advantages compared to conventional systems. Savings are achieved, among other things, by eliminating transformers and reducing system costs through lower currents. The impact of the technology is outstanding and has the potential to revolutionize the storage market. This is reflected in the outstanding economic efficiency of the high-voltage lithium storage. It is at least 33% higher compared to TESLA, BYD, E3DC and results from the following factors: Higher number of charge cycles (8,000), max. depth of discharge, higher energy efficiency (92%), low investment costs (570 €/kWh) and low system costs (50% reduction). In SME Phase 2, the product is to be made ready for series. Serial production and commercialization are to be carried out. Commercial enterprises in i.a. Europe, East Asia and USA are to be reached (market size: 1.1 bn €). The high-voltage lithium storage (TRL7) was developed by TESVOLT GmbH. The global challenge of establishing renewable energies as the main pillar of energy supply can only be met with intelligent energy storages. TESVOLT -The energy storage experts.

Keywords: energy storage,renewable energies,high voltage battery management system