Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structural Neuroimaging in ADHD – Brain Development from Childhood to Adulthood (NeuroADHD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2026-10-31
Duration (months): 46.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, with 5% of children and 2.5% of adults being affected. Core symptoms include inattention, hyperactivity, impulsivity, and cognitive dysfunctions, causing a significant burden in multiple domains of daily life. Delayed brain maturation in childhood and adolescence is suggested as neurobiological underpinning of ADHD, but longitudinal studies are scarce and have partly revealed divergent results. The aim of the present project is to investigate the neurobiological mechanisms underlying the developmental course of ADHD within an independent, closely monitored, and well-characterized longitudinal sample (Dutch NeuroIMAGE cohort). Brain anatomical scans of initially 1,069 children (with and without ADHD) will be analysed with regard to the development of cortical thickness, surface area, and subcortical volumes, from childhood over adolescence into adulthood. An additional ultra-high field (7 Tesla) brain scan acquired in young adulthood will be used to precisely investigate cortical myeloarchitecture. All measures will be analysed with respect to clinical outcomes, that is, comparing patients with persistent ADHD, patients with ADHD in childhood who have remitted into adolescence or adulthood, and healthy controls. To further understand what mediates or moderates individual differences in ADHD-associated brain maturation, the role of genetic and environmental risk factors will be considered. This project is expected to lead to an enhanced overall picture on the developmental trajectories of ADHD. Identification of interindividual differences between individuals with persistent ADHD and those who recover as well as influencing factors will not only provide further insights into the neurobiological underpinnings of ADHD, but could also have high value for individualization and optimization of treatment approaches.

Keywords: adhd,brain structure,development,longitudinal,intracortical myelin
Improving outcoMes and imPact from scenArio based licensing: Classical_Crisis and Co-creaTed IP (IMPAC3T-IP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Italy,Spain,Ireland,Finland,Germany,Netherlands,United Kingdom,Belgium
Call: Toolbox for efficient IP licensing for market uptake and societal value creation (CSA) (HORIZON-CL4-2023-HUMAN-01, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 2299131.03
EU funding (EUR): 1823772.77
Participants: 10
Project status: SIGNED

IMPAC3T-IP is an ambitious coordination and support action that aims to develop, pilot and support the sustainable adoption of a scenario based licensing tool-box through a certified user and trainer programme, for efficient IP licensing for market uptake and societal value creation. IMPAC3T-IP aims to identify current gaps and shortcoming in available licensing tools for 3 main scenarios, stakeholders, IP assets and licensing outcomes; investigate new and emerging technology trends to support licensing and evaluate the feasibility of incorporating them into the tool-box either now or in the future; develop, test, pilot and refine the tool-box through stakeholder engagement and launch, disseminate and sustain the toolbox through a sustainable accredited and certified ‘user’ and ‘trainer’ training programme (IMPAC3T-IP Academy). These objectives are pertinent to the Destination of the HORIZON-CL4-2023-HUMAN-01-31 work program to deliver a human-centred and ethical development of digital and industrial technologies, particularly by enabling a wider range of desired licensing outcomes alongside pure economic benefit e.g. impact, and socially responsible licensing, as well as by systematically expanding the range of IP assets to be supported for licensing beyond the traditional industrial rights for inventions (patents and trademarks), into more modern bundles of rights needed to license digital technologies, including IoT, AI and ML and mobile technologies e.g. data sharing and standards essential patents (SEP). The objectives are also pertinent to the work-programme KSO of creating a more resilient, inclusive and democratic European society, prepared and responsive to threats and disasters, addressing inequalities and providing high-quality health care, and empowering all citizens to act in the green and digital transitions.

Keywords: ipr licensing,tool box
Conjugated polymers with interchain aromaticity (INTERCHAIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1499103.0
EU funding (EUR): 1499103.0
Participants: 1
Project status: SIGNED

INTERCHAIN aims to develop and investigate a ground-breaking new molecular design concept for conjugated polymers. The concept is expected to enable the occurrence of stacked-ring aromaticity between polymer chains, drastically advancing our fundamental understanding of stacked-ring aromaticity and introducing a route to exploit this effect for the development of conjugated polymers with excellent charge transport properties. For conjugated polymers with excellent charge transport properties, strong intermolecular interactions are needed, which is difficult to achieve without compromising processability. However, as an emerging class of organic molecules, conjugated macrocycles provide an exciting playing field for the discovery of effects and properties that cannot usually be achieved. In contrast to other molecules, conjugated macrocycles can sustain global aromatic or antiaromatic ring currents, offering exciting prospects to enhance the properties of conjugated materials by enabling exceptionally strong intermolecular interactions. If the macrocycles used are antiaromatic, the interactions between two macrocycles can even result in stacked-ring aromaticity. Integrated into the backbone of conjugated polymers, such macrocycles may enable interchain stacked-ring aromaticity and interchain π‐electron delocalisation, in addition to intrachain π‐electron delocalisation. However, the inherent instability of the required antiaromatic molecules poses a tremendous challenge for the investigation of stacked-ring aromaticity and prevents the development of polymers that exploit this effect. INTERCHAIN proposes a ground-breaking new molecular design concept that overcomes this challenge by eliminating the need for antiaromatic molecules to achieve stacked-ring aromaticity. The project will drastically advance our fundamental understanding of stacked-ring aromaticity, but it will also yield highly stable conjugated polymers with excellent properties for applications.

Keywords: conjugated polymers,conjugated macrocycles,molecular design of organic materials,stacked ring aromaticity,structure property relationships,organic polymer semiconductors
FINE-TUNING T CELL NETWORKS OF EXHAUSTION BY SYNTHETIC SENSORS (T-FITNESS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,France,Italy,Switzerland,Spain,Slovenia
Call: Emerging Technologies in Cell and Gene therapy (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 4387825.75
EU funding (EUR): 4387825.75
Participants: 9
Project status: SIGNED

Cell and gene therapies offer a massive paradigm shift from current treatment options and hold the potential to cure previously untreatable diseases. Naturally-occurring and genetically modified T cells with chimeric antigen (CAR) or T cell receptors (TCR) have demonstrated remarkable curative capacities against advanced hematologic malignancies but have shown limited efficacy in treating solid tumors. Major barriers hindering the full antitumor potential of T cells are the immunosuppressive signals and persisting antigenic stimuli within the tumor microenvironment that inexorably push T cells into a highly dysfunctional state called “exhaustion”. Herein, we propose a groundbreaking technology, T-FITNESS, which will enable antitumor T cells to become refractory to exhaustion. At the core of the platform are microRNA (miRNA)-based synthetic logic circuits capable of rewiring the transcriptional networks orchestrating T cell exhaustion. By harnessing the power of CRISPR/Cas genome editing, we will integrate sensors of miRNAs upregulated in exhausted cells into untranslated regions of one or more transcription factors driving T cell exhaustion, to enable their fine-tuned downregulation. We will validate the reprogramming efficacy of T-FITNESS by performing extensive functional analyses in vitro and in vivo and advance the best circuits towards the clinic by developing an automated cGMP-compliant manufacturing process for point-of-care production of T-FITNESS-edited CAR-T cells. To develop this innovative platform, we will bring together a multidisciplinary consortium of academic and industry partners that combine their unique expertise in T cell therapy and immunology, synthetic biology, genome editing, cGMP manufacturing, bioinformatics, and communication. Easily integrable within CAR-T, TCR-T, and tumor-infiltrating lymphocyte (TIL) platforms, T-FITNESS will unleash the curative potential of T cell therapy for the benefit of an ever-growing number of cancer patients.

Keywords: car t therapy t cell exhaustion synthetic circuits crispr cas micrornas transcriptional regulation cgmp manufacturing
Unravelling the role of neuronal antibodies and innate immunity partnership in human autoimmune encephalitis (ImmuBRAIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: SIGNED

Autoimmune encephalitides (AE) are severe brain disorders mediated by antibodies against neuronal proteins, such as the N-Methyl-D-Aspartate receptor (NMDAR). The antibody effects are reversible, explaining recovery after antibody-depleting therapies. However, it is unknown why many patients have incomplete recovery and persistent deficits. In these cases, additional immune mechanisms might be at play. The objective of ImmuBRAIN is to define how the adaptive immune response (autoantibodies) cross-talks with innate immune-mechanisms, resulting in neuronal dysfunction or death, by using NMDAR encephalitis as a disease model. Cutting-edge antibody engineering will define the unexplored contribution of antibody glycosylation (which modulates innate functions) to neuropathology. ImmuBRAIN combines human studies with experimental models. Human studies will extensively profile patients’ NMDAR antibodies using a novel antibodyomics platform; characterize the compartmentalized antibody responses between brain and periphery using B-cell receptor repertoire analyses; define the distribution of brain innate infiltrates and quantify neuronal death using advanced microscopy. In vitro models will determine the effects of patients’ and glycan-modified antibodies on neurons using confocal microscopy and electrophysiology; explore the neuron-microglia interactions during trogocytosis using super-resolution and live cell imaging. Finally, a new mouse model of NMDAR encephalitis will serve to define the dynamics of antibody and innate responses over time and at different disease stages, and explore the therapeutic role of in vivo antibody glycan modifications in reversing the observed behavioural and molecular alterations. These findings will revolutionize the current understanding of innate immune mechanisms in AE and other inflammatory brain disorders, and will provide novel antibody-modulating therapies (e.g., glycan modifications) that will ultimately improve patients’ outcomes.

Keywords: autoimmune encephalitis pathogenic immune mechanisms antibody and innate immunity neuronal death clinical outcomes
A circular economy platform for treatment of wastewater by blue green microalgae (WWTBP-by-Microalgae)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-11-30
Duration (months): 26.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

Water pollutions and increasing atmospheric CO2 levels are two critical environmental issues causing significant harmful effects on the environment and human health. Biological wastewater treatment using microalgae has been intensively studied in recent years. However, its implementation has been hindered due to challenges associated with the high costs of harvesting and drying steps. Therefore we aimed to design an integrated platform utilizing microalgae with the minimized cost of harvesting without any drying step. In our designed system, we will harness the power of blue-green microalgae due to their high capacity to sequester CO2, digest wastewater, and accumulate high concentrations of pigment (phycocyanin, a blue pigment). We will encapsulate cells in the first reactor to protect the cells from high concentrations of pollutants, while in the secondary reactor, filamentous microalgae can treat partly treated wastewater and then be flocculated by adjusting mixing speed. The growth of microalgae will be monitored by a respirometer, which estimates the algal growth kinetics based on the oxygen production and proton consumption rate. Subsequently, the flocculated biomass will be harvested and will undergo pigment extraction in water, as phycocyanin is a water-soluble pigment. The high phycocyanin price (approximately 221 Euro/kg) adds additional economic viability. The wet pigment-free biomass still contains compounds that can be anaerobically digested to biogas. The generated biogas can be utilized to provide energy for the system, while the emitted CO2 can be recycled back for microalgae cultivation. The digestate of microalgal biomass still contains carbonic material, which can be further transformed into high-value compounds such as bio-crude oil, biochar, and liquid phase through hydrothermal liquefaction. Thus, this project offers a circular economy platform that offers conversion of waste (wastewater and CO2 emissions) to high-value products.

Keywords: wastewater treatment,microalgae cultivation,circular economy,biomass conversion
Neural Stem Cell Coordination: a Developmental, Evolutionary and Circuit perspective (NSC-CoDEC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1497575.0
EU funding (EUR): 1497575.0
Participants: 1
Project status: SIGNED

The adult mammalian brain exhibits a remarkable capacity of adaptation, which has long been thought to result from synaptic remodeling of neurons born during development. Importantly, the discovery that new neurons can be generated in the adult by neural stem cells (NSCs) revolutionized our understanding of brain plasticity. In the adult mouse brain, NSCs reside in two specialized niches: the dentate gyrus (DG), and the ventricular-subventricular zone (V-SVZ) lining the lateral ventricles. Although anatomically and functionally different, these two neurogenic regions share several cell types, including the glial NSCs and their lineage, and are sensitive to similar environmental stimuli. This raises the exciting possibility that NSCs within and between niches could coordinate their behavior under specific contexts. I recently showed that in the V-SVZ, regionally-distinct NSC pools can selectively and transiently respond to specific physiological states. However, such spatial and functional stem cell diversity in the DG remains to be investigated. Here, we hypothesize that the two brain niches form a single plasticity-generator system, comprising multiple stem cell subpopulations, some of which may be inter-dependent. We will first investigate whether some NSC pools across both niches share unexpected molecular features and developmental trajectories. To determine whether and how this V-SVZ/DG system evolved to sustain a plasticity-oriented, regionally-restricted, and transient process in mammals, we will perform comparative transcriptomics with a contrasting model of adult neurogenesis in Zebrafish, which is regeneration-oriented, widespread and continuous. Finally, we will test whether the recruitment of specific adult NSCs in the mammalian brain is orchestrated by neuronal circuit activity outside the niche. Altogether, our work will uncover the molecular, cellular and circuit logic of adult mammalian neurogenesis in light of NSC heterogeneous identities.

Keywords: adult neurogenesis,molecular neuroscience,transcriptomics
ENcouraging Farmers towards sustainable farming SYstems through policy and business Strategies (ENFASYS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Belgium,Serbia,Greece,France,Norway,Ireland,Italy,Germany,Switzerland
Call: Uncovering lock-ins and levers to encourage farmers to move to and stay in sustainable, climate-neutral and biodiversity-friendly farming systems: from experiments to systemic mechanisms (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 3997625.0
EU funding (EUR): 3997625.0
Participants: 12
Project status: SIGNED

ENFASYS aims to stimulate a just and robust transition to sustainable, productive, climate-neutral, biodiversity friendly and resilient farming systems (SFS) by improved policies and business strategies that encourage farmers to change their production systems. In current food systems, farmers are challenged by multiple lock-ins that prevent them to move to SFS. To overcome this and thus to support the Green Deal and in particular the Farm to Fork ambitions, strengthening public strategies (policies) should go hand in hand with strengthening private strategies (business models, social innovations). To reach this aim, ENFASYS goals are (1) an improved understanding of lock-ins and levers in farming and food systems;(2) an improved understanding of behavioural factors of farmers, consumers and other food chain actors;(3) more and better evidence on the potential effectiveness of interventions;(4) a more structured approach to link knowledge to action. To do so, ENFASYS will frame current transitions to SFS and screen 160 cases for current interventions. Through systems analysis, behavioural and experimental studies, ENFASYS will uncover lock-ins from a systemic and behavioural point of view. The potential of policy and business interventions will be tested in 12-15 countries across Europe through experimental studies (discrete choice experiments, framed field experiments and randomized trials) and system dynamic modelling. To link systemic and behavioural insights to action and to understand the impact of the interventions on systems level, results of these studies will be combined into system and behavioural based theories of change. Together with stakeholders and enriched by the research results, ENFASYS will co-design policy mixes, business strategies and social innovations and stimulate their implementation. Strategic communication, dissemination, exploitation and tailored capacity building towards all our target groups, will maximize ENFASYS’ impact.

Keywords: experimental studies,systems approach,behavioural approach