Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
STRONGLY INTERACTING 1D BOSE GASES (INTERACT1DBOSON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2010-08-31
Duration (months): 16.0
Total project cost (EUR): 164208.45
EU funding (EUR): 164208.45
Participants: 1
Project status: CLOSED

The physics of interacting one-dimensional systems is very different from that of ordinary three-dimensional configurations. In systems where the dynamics is constrained to only one dimension, interactions play a special role since particles can not avoid each other. As a result, the behaviour of 1D systems turns out to be very peculiar and often counter-intuitive, making them very interesting to study. For example, interacting 1D bosons have the fascinating property to “fermionize” as strong interactions mimic the Pauli exclusion principle. It has been proposed that such one-dimensional systems could be obtained by loading degenerate atomic gases in optical dipole potentials. The scientific interest for the realization of strongly correlated systems goes beyond the field of cold atoms as it might shed new light on long-standing issues in condensed matter physics. Some first experiments have been realized to manipulate such strongly interacting 1D Bose gases. Here, we propose to use optical dipole potentials (a red-detuned 2D lattice and a blue-detuned beam controlling the longitudinal curvature) to create strongly correlated degenerate 1D Bose gases. Such a setup will allow us to continuously tune our 1D gases from the mean-field regime to close to a “fermionized” Bose gas (Tonks-Girardeau regime). We plan to implement a Bragg spectroscopy scheme with a tunable angle and to make use of the noise correlation technic to quantitatively characterize the correlations in the 1D gases, including the spatial extent of correlation functions and their scaling with the strengh of interactions. In addition we propose to study metal-insulator quantum phase transitions induced by the presence of an optical lattice (Mott transition) or a disordered potential (Bose Glass phase) in the strongly interacting regime. A clear identification of these new insulating quantum phases should be provided by the use of the Bragg spectroscopy and noise correlation technics.

Keywords: atomic physics,bose-einstein condensate,one-dimensional,correlations,spectroscopy,metal-insulator phase transition
Metal-containing Functional Polymers through Subcomponent Self-Assembly (MECOFUPO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-01
End date: 2011-04-30
Duration (months): 24.0
Total project cost (EUR): 171300.62
EU funding (EUR): 171300.62
Participants: 1
Project status: CLOSED

This research proposal comprises two projects grouped around the idea of generating new polymeric materials using the technique of subcomponent self-assembly, which allows the preparation of complex structures from simple building blocks that come together around metal-ion templates via coordinative and covalent bond formation. The success of Part A will result in the preparation of double-helical polymers consisting of two self-assembled organic polymer strands that wind around a linear array of copper(I) ions. Initial studies have validated the concepts behind our synthetic strategy, and electrochemical measurements together with DFT calculations indicate a high level of electronic delocalization between the copper ions indicating that these polymers could serve as electrically conductive “molecular wires”. Part B will generate a different series of modular metal-organic polymers, consisting of a poly(imine)chain built up using a high-yielding imine exchange reaction. This chain will be bound to and stabilised by copper(I) ions that are also linked to ancillary ligands that fit snugly around the polymer chain using the idea of “steric complimentarity”. Once we have worked out the scope of the chemical reactions underpinning the formation of these polymers, a wide variety of different polymeric materials are predicted to be accessible. Key properties of these materials, such as strength, flexibility, and conductivity, will be tuneable through the incorporation of different monomer units. The self-assembly reactions used to generate these polymers will be carried out in aqueous solution. Water will be the only by-product of many of the condensation reactions that generate polymers. Our objectives in undertaking this project are twofold: to generate new polymeric materials that might possess useful properties (such as electrical conductivity and the ability to self-repair through dynamic reassembly), and to advance the knowledge of molecular self-assembly.

Keywords: polymer chemistry,inorganic chemistry,self-assembly,coordination chemistry,electrochemistry
Role of mitochondria-shaping proteins in T cell development and migration in vivo. (DYNA-MITO IN THYMUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-01-01
End date: 2011-12-31
Duration (months): 24.0
Total project cost (EUR): 180801.44
EU funding (EUR): 180801.44
Participants: 1
Project status: CLOSED

Mitochondria are highly dynamic organelles that continuously move, divide and fuse in a highly regulated fashion. The balance between the opposing processes of mitochondrial fusion and fission is controlled by a growing family of “mitochondria-shaping” proteins. Evidence is accumulating on the role of these proteins in several functions, from apoptosis to Ca2+ signaling, to morphogenesis of dendritic spines and synapses, to regulation of migration of leukocytes. The knowledge of the regulation of mitochondrial dynamics, as well as its impact on tissue development and homeostasis is currently limited. This project hypothesizes that changes in mitochondrial morphology are crucial events in determining migration and development of T cells in the thymus. We will capitalize on the mouse models available in the host laboratory to (i) address whether mitochondrial dynamics regulates motility of lymphocytes in intact mouse thymic lobes; (ii) understand whether pro-fusion or pro-fission proteins regulate T cell development; (iii) dissect the role of fusion vs. antiapoptotic effect of pro-fusion protein in T cell migration and development. Our project is expected to clarify the role of mitochondrial dynamics in a complex immunological scenario like thymic development.

Keywords: mitochondria,thymocyte,dynamics,fusion-fission,apoptosis
Study of magnetic responsive biopolymer based materials (MAGBIOMAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 165444.54
EU funding (EUR): 165444.54
Participants: 1
Project status: CLOSED

The aim of the proposed project is to synthesize and characterize new nanostructured magneto-responsive biopolymer-based materials by the introduction of functionalized magnetic nanoparticles in biogel and foam to gain a deeper understanding of two fundamental aspects: - The understanding of the formation mechanisms of such structures: magneto-responsive networks. - The correlation between the behaviour of the nanostructured composite biopolymer-based materials under the change of external conditions, such as magnetic field, shear, ionic strength, pH and composition of polymer and magnetic nanoparticles or the chemical structure of the constituents. The research project will involve different aspects. On one hand, it will include the elaboration of new magnetic-responsive biopolymer-based materials. On the other hand, the project will try to develop specific dedicated apparatus, allowing the measurements of mechanical properties under magnetic field to determine structure and dynamical properties at different external conditions as well as kinetics of structure transformation of such systems controlled by magnetic field. The combination of synthesis, characterization and theory will allow a synergy for the elaboration and optimization of novel magnetic-responsive biopolymer based materials with fine tuned properties and for their future application in industry (vehicle for drug delivery, intelligent materials for medical and structural applications).

Keywords: chemical physics,surface physics,magnetic fluids,biogel,rheology
Significance of TDP-43 in the population in relation to dementia (STPRD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-04-04
End date: 2011-09-03
Duration (months): 29.0
Total project cost (EUR): 182484.78
EU funding (EUR): 182484.78
Participants: 1
Project status: CLOSED

The incidence and prevalence of dementia is rising as the world-wide population ages. Determining biomarkers for the early detection of underlying biology that will predict dementia progression reliably or, the monitoring of biological processes once present to track progression and treatment is necessary. Furthermore, these biomarkers will aid in the differentiation of dementia from normal ageing and between its subtypes, and in the development of sensitive and specific diagnostic and treatment methods. The current study will be the first to assess a new protein-aggregating biomarker of dementia, TAR-DNA-binding-protein-43 (TDP-43), in a population-based sample. TDP-43 was implicated in the biology of dementia in 2006 however its relevance to the population is unknown. This study will assess the significance of TDP-43 in relation to dementia in a population sample of older people who have undergone brain donation. The sample (n=350) is from the European Clinicopathological Studies in Europe (EClipSE). Each participant has been tracked longitudinally for up to twenty years (dependent on date of death), with clinical (e.g., dementia and other diagnoses such as diabetes, cognition and psychological symptomatology) data available. The three study objectives are: • The determination of the prevalence of pathological TDP-43 expression in a population-based sample of older people as a whole and relative to dementia status. • The determination of the relationships between pathological TDP-43 expression and other neuropathological markers of dementia as well as longitudinal cognition and psychological symptomatology. • The development of clinical criteria which are sensitive and specific to the presence of pathological TDP-43 expression during life. These investigations will have significant implications for the diagnosis, management and treatment of dementia syndromes, with the aim of decreasing the social and economic costs of dementia.

Keywords: degenerative diseases,dementia,neurobiology,population
Sequential encounters as the evolutionary drivers of choice mechanisms (SEEDCM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-04-01
End date: 2011-03-31
Duration (months): 24.0
Total project cost (EUR): 174702.68
EU funding (EUR): 174702.68
Participants: 1
Project status: CLOSED

Introspection often creates the perception that our decisions are driven by the evaluation of each alternative, and as a consequence we assume that animals also choose by evaluating alternatives. If this were true, choosing would take information-processing effort and time: more options, more time. However, in starlings, this pattern does not hold. The Sequential Choice Model (SCM) was proposed to deal with this curious finding. Its main feature is that it predicts behaviour in choice situations using data from no-choice encounters with each alternative. Its premises are: (1) When an animal faces a single option, it doesn’t take it immediately (the “latency”). Each alternative faced on its own elicits a specific probability density function of latencies. Latencies are not reaction times: they exceed RTs duration by an order of magnitude and have different properties; (2) Latencies to take single options are decreasing functions of the improvement in state-dependent fitness that the decision maker expects from that option relative to the context; (3) Expectations about each option depend on both the subject’s state and the average properties of the environment during learning; (4) When more than one option is met simultaneously, each elicits a sample from its original distribution of latencies. The shortest sample is expressed as a choice. There is no comparative evaluation at choice time: each option elicits a candidate latency just as in sequential encounters. This cross-censorship between latency distributions means that latencies for each option are shorter when picked out of a choice than when picked in the absence of alternatives. The SCM was proposed for a system with pairs of options, where its predictive performance was very successful. To investigate its generality, I will now test it in a wide variety of choice paradigms, including multi-alternative choice, the time-left procedure, risky choice and comparative valuation scenarios.

Keywords: natural sciences,social sciences,sequential choice model,latency,choice,multi-alternative scenarios,time-left,risky choice,comparative valuation,starlings.
DNRG-1 as a marker to develop better models for characterising human and mouse dendritic subsets and for analysing their functional role in vivo. (CD8DC FUNCTIONS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 180783.75
EU funding (EUR): 180783.75
Participants: 1
Project status: CLOSED

The dendritic cell (DC) system of antigen-presenting cells controls immunity and tolerance. The unresolved issues on DC heterogeneity represent an important hurdle in the development of DC-based immunotherapies. The identification of the DNGR-1 marker by the host lab allows us to develop better models for characterising human and mouse DC. In the mouse, this marker is selectively expressed in mouse CD8+DC and then, we believe that it constitutes a better marker for CD8+DC in vivo and, therefore, will carry out a detailed analysis of the distribution of DNGR-1+ cells. We plan also to extend our work to imaging CD8+DC and their interactions in vivo with T and B cells, and other DC as langerhans cells. This aim will be achieved by using and constructing knock-in (KI) mice that express a green or red fluorescent protein specifiquely to tag the CD8+DC. The function of CD8+DC remains speculative, in part because of the lack of models in which only one DC subtype could present a given antigen to T cells. We aim to circumvent this limitation by restricting the ability to present a given antigen to the CD8+DC. They are also a lack of models in which DC subtypes can be selectively ablated. The host laboratory has constructed mice to deplete, transiently or constitutively the CD8+DC. This model will allows us to assess the effect of ablation of CD8+DC on the immune system. In humans, it has been argued that CD8+DC are not present but this could simply reflect the fact that they have been overlooked. The host lab showed that DNGR-1 is also expressed by a small subset of human blood, sharing markers with mouse CD8+DC. Then, we plan to characterise the functional properties of human DNGR-1+DC in detail and determine whether they match those expected from the study of murine CD8+DC. Based on our results, strategies that aim to define cancer immunotherapies could refine their approach, as our work will transpose mouse data to a better understanding of human DC.

Keywords: dendritic cells,mouse,human,functions,cd8alpha+ dc,in vivo models,reporter knock-in mice,depletion,vaccine
THE EMERGENCE OF A BIOSOCIETY. Toward an "anthropology of the contemporary" (BIOSOCIETY2008)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 173185.81
EU funding (EUR): 173185.81
Participants: 1
Project status: CLOSED

This research project aims at providing a detailed description of the powerful hegemony of leading intellectual enterprises like neuroscience and molecular biology and their current impact on society. Its major objective is an analysis of the fundamental shift, over the last thirty years, from culture to biology, from language to the brain, from ethics to genes, in the explanation of what makes us specifically human. The present age is one in which the intimate boundary between biology and history is being renegotiated: although human beings are certainly not more biological beings than they were thirty years ago, they tend to identify themselves, explain themselves, see their image, more and more through the lens of neurobiological, genetic and molecular terms. At the dawn of the 21st Century, the discourse of biology has become the basic vocabulary through which describe the human condition, rapidly absorbing any potentially alternative language, both at the level of the individual and that of society. Clearly, this shift has a direct impact on how Modernity is conceptualised in terms of what one may call &apos;Biosociety&apos;. In the vein of Michel Foucault’s “history of the present” (Foucault 1986), Paul Rabinow’s “anthropology of the contemporary” (Rabinow 2003, 2007), and Nikolas Rose’s “cartography of the present” (Rose 2007), the project will address this phenomenon mainly according three lines of enquiry: I) a genealogical reconstruction in terms of intellectual history of the main factors that have contributed to the return of a biology-centered paradigm at the turn of the century II) a sociological analysis of the emergence of new forms of subjectivities and identities that are currently built in a biological, and molecular, style of thought III) a theoretical study of the current process of biologization and naturalization of human identity and its impact upon the European culture, and its philosophical, anthropological and Humanistic legacy

Keywords: social and critical theory,social effects of science and technology,new forms of subjectivity,life sciences,naturalism,continental thought,neuroscience,conceptual metaphor analysis
Novel polymeric ionic liquids dor environmental sensing and purification (PIL-4-E-S&P)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-04-15
End date: 2011-04-14
Duration (months): 24.0
Total project cost (EUR): 154102.06
EU funding (EUR): 154102.06
Participants: 1
Project status: CLOSED

The target of this project is to develop novel materials for new electrochemical sensors and for purification of the environment. Success in this area will open up new frontiers for detection and protection of environment from hazardous chemicals. The material research will focus on preparation of polymer ionic liquids and its evaluation as materials for electrode modification for sensors and as porous absorbers for hazardous chemicals. This fellowship will bring together a strong portfolio of skills from Dr. Vasko Jovanovski (Slovenia) (Ionic Liquids, organic synthesis, academic research), with excellent training opportunities and high level research skills in complementary fields (polymers, electrochemical sensors, industrial research) at CIDETEC, Centre for Electrochemical Technologies (Spain). This will create a unique combination of expertise that will be beneficial to both parties. Together, this team will acquire key skills and insight to deliver significant breakthroughs in the European environmental sensing and protection area.

Keywords: macromolecular chemistry,instrumental analysis,environmental science
The identification and mapping of Essential Fish Habitats using Geographic Information Systems (EFH-GIS) (EFH-GIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-01-01
End date: 2012-05-01
Duration (months): 24.0
Total project cost (EUR): 146876.08
EU funding (EUR): 146876.08
Participants: 1
Project status: CLOSED

Effectively managed fisheries are more likely to be sustainable and combine a healthy biodiverse marine ecosystem with an economically viable and competitive fisheries industry. Such fisheries management goals cannot be achieved if, for instance, the managed fish species do not have access to sufficient suitable habitat. The identification and spatiotemporal mapping of Essential Fish Habitats (EFHs) represent fundamental scientific tasks of the spatial component of fisheries management, a component that has often been neglected in previously enforced fisheries policies. The EFH-GIS (‘Essential Fish Habitats - Geographic Information Systems’) project aims to support the spatial component of fisheries management, by applying an interdisciplinary environmental approach to the mapping and designation of EFHs in the eastern Mediterranean Sea, an area that supports commercially important fisheries. Through five main research objectives, this two-year fellowship will see (1) the updating and enrichment of an existing GIS database, which (2) will be used to map ocean processes (e.g. eddies) to be fed into (3) the modelling of habitat for several commercially important species of fish. This knowledge will then be used (4) to identify over- and under-exploited fishing areas and also in a preliminary study to design a network of Marine Protected Areas (MPAs), which are sanctuaries to protect EFHs. The project intends to contribute to the long-term preservation of fisheries resources, as well as (5) increasing scientific knowledge and public awareness of the eastern Mediterranean marine ecosystem. The specialised training received as part of the fellowship, as well as the contribution made to scientific knowledge in this field, will greatly contribute to the fellow in terms of career and professional development, but also to Europe in terms of excellence and competitiveness.

Keywords: fisheries management,modelling and modelling tools (fisheries science),pelagic ecosystems,sustainable exploitation,biological oceanography