Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REgenerative therapy of intervertebral disc: a double blind phase 2b trial of intradiscal injection of mesenchymal stromal cells in degenerative disc disease of the lomber SPINE unresponsive to conventional therapy (RESPINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Ireland,Italy,Spain,France,France,France,France,France,France
Call: Clinical research on regenerative medicine (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2023-06-30
Duration (months): 78.0
Total project cost (EUR): 5555836.25
EU funding (EUR): 5555836.25
Participants: 20
Project status: SIGNED

The World Health Organisation (WHO) has included low back pain in its list of twelve priority diseases. Notably, Degenerative disc disease (DDD) presents a large, unmet medical need which results in a disabling loss of mechanical function. Today, no efficient therapy is available. Chronic cases often receive surgery, which may lead to biomechanical problems and accelerated degeneration of adjacent segments. Our consortium partners have developed and studied stem cell-based, regenerative therapies with encouraging results in phase 1 and 2a trials. Patients exhibited rapid and progressive improvement of functional and pain indexes by 50% within 6 months and by 65% to 78% after 1 year with no side effects. In addition, MRI T2 relaxation measurements demonstrated a significant improvement. To develop the world’s first rigorously proven, effective treatment of DDD, RESPINE aims to assess, via a multicentre, randomized, controlled, phase 2b clinical trial including 112 patients with DDD, the efficacy of an allogenic intervertebral mesenchymal stem cell (MSC)-based therapy. This innovative therapy aims to rapidly (within 3 months) and sustainably (at least 24 months) reduce pain and disability. In addition, the consortium aims to provide new knowledge on immune response & safety associated with allogeneic BM-MSC intradiscal injection. This simple procedure would be cost-effective, minimally invasive, and standardised. The transfer to the clinic will be prepared at a cost below 10k€ thanks to the strategy of production of allogenic cells, automation & EU standardisation. At the end of the RESPINE trial, we aim to propose a broadly available and clinically applicable treatment for DDD, marketed by European SMEs.

Keywords: degenerative disc disease,allogeneic msc therapy
Antiferromagnetic straintronics: towards an non-volatile all-voltage controlled memory device (PiezoSpin)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The holy grail of magnetic storage research is the discovery of novel all-voltage controlled magnetic metamaterials that enable to develop a universal memory device that simultaneously meet high-power-efficiency and ultra-high storage capacity. Antiferromagnetic (AFM) materials could represent the future of spintronic applications as a result of the numerous interesting features they combine, e.g. they are robust against perturbation due to magnetic fields, produce no stray fields, display ultrafast dynamics and are capable of generating large magneto-transport effects. However, the truly distinctive feature posed by AFM materials when compared to ferromagnetic ones is its modulated magnetic order, which is marginally exploited in spintronics applications. The PiezoSpin project seeks to demonstrate a novel proof-of-concept for an innovative universal ultra-high power-efficient AFM-based spintronics memory device, which has the potential for transforming the ferromagnetic-dominated magnetic data storage technology. We will produce hybrid FeRh-based alloy/ferroelectric (FE) heterostructures, where the FeRh-based alloy overlayer will act as a resistive-switch driven by the FE underlayer acting as a voltage-controlled actuator. We will investigate the strain-dependent electrical resistivity of the FeRh-based alloy on the applied voltage. This piezo-magnetoresistivity effect will be optimized by chemical doping of the FeRh-based alloy to maximize that strain-dependent resistivity change at room temperature. This novel hybrid device concept exploits the strain-dependent giant magnetoresistance that appears in spin-orbit coupled (anisotropic) AFMs. Its origin resides in the superzones band-gap effect as a result of the onset of modulated magnetic order. Such piezo-magnetoresistivity effect is shared by numerous AFMs, opening up a new research field, i.e. AFM-based strain-electronics, where the material combinations and functionalities to explore are immense.

Keywords: antiferromagnets,bulk like giant magnetoresistance,spintronics,nanomagnetism,straintronics,memory devices
Algebraic Group Actions in Geometry, Arithmetic, and Physics (AGAGAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-17
End date: 2019-08-16
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Geometry, arithmetic, and quantum physics historically have had many points of intersection. This project will use recent techniques in algebraic group actions, especially those of Kirwan, to address problems of overlapping interest to distinct research groups at the University of Oxford – Algebraic Geometry, Number Theory, Mathematical Physics, and the Centre for Quantum Mathematics and Computation. Consider the following long-standing, a priori unrelated, questions. What is the minimal degree curve that passes through n points in general position in the plane (Nagata conjecture)? What is the growth rate of the number of integer lattice points in a variety (for us, universal torsor over a Fano variety) with respect to a height function (Manin conjecture)? How can one work with quantum entanglements of different qualitative character and associated entropies in a rigorous yet experimentally friendly way? These open questions turn out to admit a common source, at least in a large class of problems of interest. The crucial ingredient is a suitable "homotopic replacement for a universal torsor" -- arising, in nice cases, from a key difference with topology, since in algebraic geometry algebraic affine line bundles needn't be vector bundles -- that often allows one to reduce to studying a simpler problem in group actions attached to an affine space rather than to a complicated variety or even more complicated universal torsor.

Keywords: geometric invariant theory,quotients,polytopes,unirational varieties,rational points of bounded,height,effective cycles,quantum entanglement
Edible Cities Network Integrating Edible City Solutions for social resilient and sustainably productive cities (EdiCitNet)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Innovation actions
Countries involved: Germany,Spain,Austria,Spain,Germany,Spain,Germany,Uruguay,Austria,Cuba,Tunisia,China,Norway,Slovenia,Slovenia,Norway,France,Netherlands,Netherlands,United Kingdom,United Kingdom,Togo
Call: Demonstrating innovative nature-based solutions in cities (H2020-SCC-NBS-2stage-2017, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 11763163.52
EU funding (EUR): 11254912.879999999
Participants: 40
Project status: SIGNED

The systemic use of urban landscapes for food production is a major step towards more sustainable, liveable and healthier cities. A multitude of initiatives around the World, however fragmented, are prospering, forming a global movement of Edible Cities. Their products, activities and services – the Edible City Solutions (ECS) - empower local communities to overcome social problems by their inclusive and participatory dynamics and to create new green businesses and jobs, and thereby generating local economic growth and fostering social cohesion. EdiCitNet will leverage the substantial benefits that ECS effect today at local level and catalyse their replication EU- and world-wide by launching a fully open and participatory network of cities, empowering their inhabitants by a common methodology a) to systematically explore the wealth and diversity of existing ECS, b) to adapt, plan and implement successfully proven ECS in their specific urban context. To make this happen, EdiCitNet will close knowledge gaps in the effective implementation of ECS and their transformation into sustainable, innovative business models. This new insight will feed into a openly shared and globally accessible knowledge base and methodology to enable sustainable and evidence-based integration of ECS into the long-term urban planning of cities covering a large spectrum of urban, climatic, social, environmental and cultural contexts. 5 Front Runner Cities (FRC), supported by a highly interdisciplinary consortium of city authorities, SME, NGOs and academia, will demonstrate their unique experience with own Living Labs and transfer their knowledge to 7 dedicated Follower Cities (FC), determined to replicate ECS for the benefit of their inhabitants. The carefully selected group of FRC and FC allows to study and monitor implementation in large variety of environments and also ensures truly global outreach with city partners based in Central America, Africa and East Asia

Keywords: edible city
Exploring Neutrinos: Cosmology, Oscillations, REactors (ENCORE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Neutrinos are the most promising sector where to look for something new in particle physics. Neutrino properties can be studied using two different approaches: with terrestrial experiments or complementary probes, such as cosmology. In this proposal we will explore both possibilities. Concerning terrestrial experiments, we will consider the problems related to the theoretical calculation of the flux of reactor antineutrinos, in light of the recent reactor anomalies and the so-called 5 MeV bump. The results will be applied to constrain the three-neutrino mixing parameters and the properties of a potential light sterile neutrino that could explain the short-baseline anomalies. A new calculation of the reactor antineutrino spectra will also have direct applications to the monitoring of nuclear power plants to prevent the development of nuclear weapons, following the efforts of the International Atomic Energy Agency. Considering cosmology, we will study the dynamics of light sterile neutrinos in the early Universe and its implications for future experimental results, as well as the clustering of relic neutrinos in the Milky Way and the consequences for their direct detection. The obtained results will be compared with all available experimental data in order to improve the current constraints on neutrino properties. Dissemination will be implemented through the publication of articles in high-impact journals, contributions to international conferences and outreach activities, including blog articles, a YouTube video and participation in open-door initiatives at the host institute. The strong network of collaborations, the importance of the treated aspects and the timeliness of the results, well justified by the current status of experimental results and the need of more precise theoretical calculations for the incoming ones, will reinforce the leading position of Europe in the international scientific community devoted to neutrino physics.

Keywords: early universe,relic neutrinos,neutrino clustering,nuclear reactors,sterile neutrinos,short baseline anomaly
University education as a driver for sustainability transitions (UNI4ST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2024-01-01
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

UNI4ST aims to create empirically grounded knowledge on how university education can be designed and performed in such a way that it becomes a fruitful driver for Sustainability Transitions (STs). Learning is considered a vital means of realising STs, but an empirical knowledge base that offers adequate guidance for the improvement of teaching and learning practices is lacking in the available literature. We address this research gap by developing a tailored analytical toolbox (methods, research instruments) for empirical investigations, inspired by pragmatist didactic research. Next, we apply the analytical tools to 3 pilot case studies of university education practices where academics, students and societal stakeholders jointly address sustainability challenges in the local community. This results in knowledge of how the design and performance of teaching and learning practices produce outcomes that promote STs. Furthermore, it allows to develop a much-needed, systematic research agenda by formulating hypotheses for future investigations. Through open access journal articles, academic conferences, a handbook, lectures, seminars, an opinion piece, workshops, a self-assessment manual for university teachers and a web-database with quality-assured practices, the results of UNI4ST are communicated and disseminated to varied audiences. Applications for follow-up research projects and a business plan facilitate the exploitation of the results. Through creating state-of-the-art knowledge and the reinforcement of methodological, management, communication and entrepreneurial skills, the experienced researcher will strengthen her international profile, visibility and network in the fields of sustainability transition studies and sustainability education research and become an internationally recognised expert on this topic. This will substantially advance het scientific maturity and strengthen her capacity to obtain a position as an indepentend researcher.

Keywords: sustainability education,sustainability transitions,transition studies,university,higher education,didactics,pragmatism,analytical methods
Efficient forestry by precision planning and management for sustainable environment and cost-competitive bio-based industry (EFFORTE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Sweden,Finland,Finland,Sweden,Sweden,Sweden,Sweden,Switzerland,Finland,Sweden,France,France,France,France,France,France,United Kingdom,United Kingdom
Call: Practices increasing effectiveness of forest management (H2020-BBI-PPP-2015-2-1, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 4203421.25
EU funding (EUR): 2230221.0
Participants: 23
Project status: CLOSED

EFFORTE draws a red line through critical, cost/benefit driving processes, and environmentally concerns of today´s forestry. Starting with efficient fulfilment of various customer demands the red line goes along efficient utilization of Big Data sources, present knowledge and critical new knowledge foreseen as outcomes from this project. Technical development and mechanization has been a winning concept for high productivity now emphasizing more gentle methods and just in time deliveries to different industry customers. This is possible to reach if new knowledge, improved methods and technical development are combined with better transfer of information and data from different sources (e.g processes, geo data from LiDAR scanning, other conditions such as weather data etc).These Big Data sources have been available for some years, but it is not until recently that hardware, data communication and merging possibilities enable full potential for a revolution of new applications. In the EFFORTE proposal we have identified three main subjects that have specific importance for efficiency, productivity and environmental concern in forest practice. Two of these implies to increasing crucial knowledge and the third, Big Data applications, combines the new knowledge with high resolution information sources into practice increasing efficiency in forest management and the connected value chains. The main objectives of EFFORTE are: i) To develop scientifically firm and techno-economically feasible methodology to predict trafficability prior to forest operations. ii) To increase forest growth and productivity of tree planting and young stand management iii) To develop, customize and pilot modern ‘Big data’ solutions that will increase productivity and decrease negative environmental impact (e.g. soil, water and reduced fuel consumption). By EFFORTE we expect to make difference in efficiency, productivity and sustainability for a growing Bio-based economy in Europe.
Investigation of adaptive design and rewiring of Survival-Apoptosis-Mitogenic (SAM) signalling transduction network (SAMNets)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

Cell life is not the property of any single protein or gene; rather it emerges from concerted actions of multiple molecules in cellular networks. Current proposal is focused on Signal Transduction Networks (STN) connecting the environment to cell responses. A major challenge is to understand how STN integrate and process environmental signals in a robust and reliable way and how they “compute” cell fate decisions depending on genetic background. To answer this question, the study will be focused on three interconnecting STNs: the Survival (PI3K/PTEN/AKT), Apoptotic (RASSF1/MST/LATS) and Mitogenic (EGFR/RAS/RAF/MEK/ERK) pathways, the SAM network. In the scope of current proposal the methods of signalling network reconstruction will be improved and the SAM network topology will be reconstructed in the panel of cell lines. Based on available data and reconstructed network topology the mechanistic site-specific dynamic model of SAM network will be developed and validated. Model predictions of dependence of signalling outputs behaviour on different perturbations (like small molecule inhibitors and their combinations) and background (mutations and protein expression levels) will be validated. The signalling outputs will be experimentally correlated to the cell fate decisions. The developed models will relate mutational information to treatment responses in the context of different expression landscapes and they will explain and predict mechanisms of intrinsic and acquired drug resistances, which often cannot be picked up by only intuitive reasoning. During the project the applicant will get training in a range of modern computational modelling, biochemical and molecular biology techniques used to study intracellular signalling networks. As a result, he will acquire skills of efficient integration of wet and dry parts of systems biology which will uniquely qualify him in the field significantly enhancing his career prospects.

Keywords: systems biology,map kinases,signalling transduction networks,cell fate,apoptosis,mathematical modelling,network reconstruction,nonlinear dynamics
Co-Translational Chaperone Action at the Single-Molecule Level (COTCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

The mechanism of protein translation by ribosomes has been the focus of recent single molecule investigations. Understanding translation at a single-molecule level is of particular interest to the life sciences and relevant for various degenerative diseases. Although protein translation and folding are well studied subjects, cotranslational folding has been proven difficult to observe. How proteins adopt their native structure with efficient fidelity while being synthesized by the ribosome remains largely unexplored. Using optical tweezers we recently measured the mechanics of synthesis and simultaneous folding in real-time, in the absence of chaperones. We found that cotranslational folding occurs at predictable sequence locations, exerting forces on the nascent polypeptide chain. We showed that transient pauses of translation occur in particular locations along the protein sequence, facilitating native secondary structure formation. Several crucial mechanistic questions concerning the effects of chaperones on co-translational folding remain unanswered: How do the chaperones trigger factor (TF), the major bacterial heat shock protein 70 (Hsp70/DnaK) and the GroEL/ES chaperonin system affect cotranslational protein folding? Do they affect the translation rate? What effect do the chaperones have on initial hydrophobic collapse? When and how often do they (un)bind? How do these chaperones assure reliable and fast native folding during protein synthesis? Here, I propose a combined optical tweezers and laser scanning confocal microscopy study to investigate the effects of chaperones on cotranslational folding in real-time, using the host's instruments, chaperones and collaboration network, as well as my previously developed cotranslational assay and collaboration network. The group of Prof. S. J. Tans at AMOLF with its expertise and experience in single-molecule chaperone investigations is ideally suited for me to pursue this study of cotranslational chaperone activity.

Keywords: cotranslational protein folding chaperones ribosome translation trigger factor tf hsp70 dnak groel,es optical tweezers force spectroscopy instrumentation fluorescence gfp gfpem dhfr htau40 mbp