Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Correlations in Large Quantum Systems (CLaQS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1876050.0
EU funding (EUR): 1876050.0
Participants: 1
Project status: SIGNED

This project is devoted to the mathematical analysis of important physical properties of many-body quantum systems. We will be interested in properties of the ground state and low-energy excitations but also of non-equilibrium dynamics. We are going to consider systems with different statistics and in different regimes. The questions we are going to address have a common aspect: correlations among particles play a crucial role. Our main goal consists in developing new tools that allow us to correctly describe many-body correlations and to understand their effects. The starting point of our proposal are ideas and techniques that have been introduced in a series of papers establishing the validity of Bogoliubov theory for Bose gases in the Gross-Pitaevskii regime, and in a recent preprint showing how (bosonic) Bogoliubov theory can also be used to study the correlation energy of Fermi gases. In this project, we plan to develop these techniques further and to apply them to new contexts. We believe they have the potential to approach some fundamental open problem in mathematical physics. Among our most ambitious objectives, we include the proof of the Lee-Huang-Yang formula for the energy of dilute Bose gases and of the corresponding Huang-Yang formula for dilute Fermi gases, as well as the derivation of the Gell-Mann--Brueckner expression for the correlation energy of a high density Fermi system. Furthermore, we propose to work on long-term projects (going beyond the duration of the grant) aiming at a rigorous justification of the quantum Boltzmann equation for fermions in the weak coupling limit and at a proof of Bose-Einstein condensation in the thermodynamic limit, two very challenging and important questions in the field.

Keywords: many body quantum mechanics,bogoliubov theory,bose einstein condensation
Unraveling the mystery of preferential degeneration of midbrain neurons in neurodegenerative diseases (oxDOPAMINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The identification of numerous genetic forms of Parkinson's disease (PD) has highlighted the importance of mitochondrial and lysosomal pathways in disease pathogenesis. In my recent work, I discovered that oxidized dopamine (DA) and alpha-synuclein serve as key mediators of mitochondrial and lysosomal dysfunction in midbrain DA neurons that preferentially degenerate in PD. It has been well established that cytosolic DA oxidizes to reactive quinones and accumulates in neuromelanin in midbrain neurons, but my data demonstrated that the process of DA oxidation was dramatically increased in disease. Importantly, oxidized DA was detected only in iPSC-derived DA neurons from familial and sporadic PD patients, but not in PD mouse models. This may at least in part explain why preclinical studies in animal models have not translated to clinical trials in PD patients. oxDOPAMINE will go one step beyond and explore the origin and nature of DA oxidation that predisposes human neurons to selective vulnerability and degeneration. Based on my preliminary work and recent genetic data implicating synaptic genes in PD pathogenesis, I hypothesize that defective synaptic DA metabolism and iron dyshomeostasis play a critical role in the oxidation of cytosolic DA early in disease pathogenesis. Since iron participates in the formation of oxidized DA in normal neurons, my project will include the examination of ‘Neurodegeneration with Brain Iron accumulation’ (NBIA) disorders that share pathological hallmarks of iron accumulation and progressive DA neuron degeneration with PD. A unifying feature of these pathogenic mechanisms is that impaired handling of DA contributes to toxicity of DA neurons. oxDOPAMINE will be of broad significance to a large cohort of patients with neurodegenerative diseases as it will advance our understanding of whether restoration of synaptic dysfunction and iron metabolism may prevent midbrain DA neurodegeneration, to represent a potential therapeutic target.

Keywords: parkinson s disease,neurodegeneration with brain iron accumulation,induced pluripotent stem cells,dopaminergic neurons,selective vulnerability of the human substantia nigra,dopamine oxidation,synaptic dysfunction,iron dyshomeostasis
Pathways to math difficulties -A longitudinal study from birth to school-age (EARLYMATH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1999608.0
EU funding (EUR): 1999608.0
Participants: 1
Project status: SIGNED

EARLYMATH is an early-onset longitudinal research program with multiple longitudinal studies that cover birth to nine years of age in order to pursue an integrative understanding of early math development and pathways to math difficulties (MD). EARLYMATH investigates the roles of individual factors (i.e., neural, cognitive, affective and motivational), as well as environmental factors in the home and early childhood education and care (ECEC) and processes of intergenerational transmission of MD. A carefully selected range of measures, including cognitive assessments, parental and teacher questionnaires, interviews, parent-child and classroom observations, and brain electrophysiology measures, will be used. The findings will produce novel understanding of the dynamics of the environmental and constitutional factors that affect the development of early-onset developmental difficulties, as well as inform theory and preventive and remediation practices.

Keywords: math difficulties,early math development,cognitive skills,motivational and emotional factors,intergenerational transmission,home math environment,ecec
Topological Mechanical Metamaterials (TopMechMat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1999264.0
EU funding (EUR): 1999264.0
Participants: 1
Project status: SIGNED

Mechanical metamaterials are man-made structures with tailored vibrational properties geared towards applications such as earth-quake protection, energy harvesting, or medical imaging. Recently, we promoted a new design principle for such materials: topological band-theory known from quantum condensed matter physics. To date, the use of topology in mechanical materials has been largely restricted to one or two dimensions, a central shortcoming for applications. The objective of TopMechMat is to address this challenge (i) by establishing a theoretical framework for topological mechanical metamaterials in three dimensions, (ii) by developing a novel algorithm enabling the sample design, and (iii) by experimentally validating the proposed materials. The current approach to topological mechanical systems is based on lcoal symmetries unnatural to classical mechanics. Crystalline symmetries, on the other hand, are ubiquitous in metamaterials and are known to stabilize topological phases. Using group cohomology techniques we will establish a theoretical framework for topological phonons in three dimensions. Translating a theoretical model into an actual sample requires extensive finite element simulations. However, the complexity of topological phonon models precludes the application of known design algorithms. We plan to use a neural network to address this challenge. This will allow us to exploit the power of genetic algorithms in executing the required large-scale parameter scans. The successful implementation of this design algorithm will present us with an exciting opportunity: Mechanical systems might enable the discovery of yet unobserved topological phases of matter. We plan to build a three-axis scanning vibrometer to investigate additively manufactured metamaterial samples. This will allow us to validate our ideas and to provide proof-of-principle results emphasizing the feasibility of our designs for concrete applications.

Keywords: metamaterials
Enhancing the innovation management capacity of SMEs in Bavaria (InnoBavaria_4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Germany,Germany
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 257448.75
EU funding (EUR): 251432.0
Participants: 9
Project status: CLOSED

Overall objective of this proposed project is to contribute to smart growth in the European Union by increasing the efficiency and effectiveness of investments in research, development and innovation (both private or public), and by contributing to a better and more efficient connection of actors along the value chain. Specifically, this proposal will contribute to increase the efficiency and effectiveness of innovation projects in SMEs in the region of Bavaria. This will be achieved by the delivery of well-defined services packages to the SMEs, targeting specifically the enhancement of their innovation management capacity and the removal of potential innovation gaps and bottlenecks.Target groups of the service packages will be 1) SME beneficiaries in Bavaria participating in Phase 1 and/or Phase 2 of the Horizon 2020 SME Instrument (“Key Account Management” KAM) 2) Other internationally oriented SMEs in Bavaria with strong ambitions in innovation and growth (“Enhancing Innovation Management Capacity” EIMC). 'Innovation management’, as addressed by this project comprises a company’s complete innovation process from idea generation to innovation result. It includes internal enabling factors like leadership, management skills, financial situation, market knowledge etc, as well as external cooperation with third parties like suppliers, R&D partners, potential clients, and investors. This understanding of innovation management follows the specifications of innovation management systems provided by the European Committee for Standardisation in CEN/TS 16555-1.For implementation, KAM case tracker and IMP³rove assessment will be used for delivering KAM services and IMP³rove as well as IHC tool will be used for delivering EIMC services, respectively.

Keywords: innovation,management,capacity,key account,sme instrument,improve,horizon 2020,cosme,enterprise europe network,bavaria2europe
Standard Collagenous ORgans-on-chip ENvisaging Advanced Biological Researches (SeCtOR ENABleRs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

SeCtOR ENABleRs aims to develop a convenient kit for the production of partially customizable organs-on-chip. The main motivations that lead us to get involved in this effort are to provide the scientific community of an easy-to-use, economically convenient and standardized microfluidic platform. This is expected to facilitate and promote the diffusion of advanced 3D cell culture systems in routine analyses and make results obtained from different experiences/laboratories more comparable. In this view we envisage possible applications in the field of stem cell biology, personalized medicine, toxicology as well as advanced pre-clinical trials. The kit main components are an ad hoc designed thermoplastic chip and a set of collagenous formulations. The chip design will allow the integration of a thermo-controller device compatible with live cell imaging techniques. A biomimetic approach and a cell-friendly crosslinking strategy will allow to control the composition and the mechanical properties of the collagenous formulations, thus approaching the complexity of natural cell environment. The flexibility of the kit will be demonstrated by obtaining vascularized neuronal and bone models using commercially available cells. Although some risky steps areforeseeable, the innovation in this project is more represented by the concept of organs on chip platform standardization than in significant disruptive breakthroughs. We are convinced that the accessibility to a convenient, standardized and flexible platform is the key to exploit the huge potentialities demonstrated by microfluidics organs on chip. The implementation of the proposed multidisciplinary work plan in an industrial environment will contribute to obtain unconventional complementary skills; understanding of the industrial perspective and needs and will finally guarantee the full exploitation of the project outcomes by establishing future SME/academics collaboration projects.

Keywords: organs on chip,collagenous hydrogels,microfluidics
EUROPEAN NUCLEAR EXPERIMENTAL EDUCATIONAL PLATFORM (ENEEP) (ENEEP)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Action type: Coordination and support actions
Countries involved: Austria,Hungary,Slovenia,Slovakia,Czechia
Call: Availability and use of research infrastructures for education, training and competence building (NFRP-2018, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 1495250.0
EU funding (EUR): 1495250.0
Participants: 5
Project status: SIGNED

The aim and the overall objective of the project is to build European Nuclear Experimental Educational Platform (ENEEP) which will fulfill needs of European users in order to significantly enhance their experimental education and hands-on activities in nuclear curricula, particularly in the field of nuclear safety and radiation protection. ENEEP will be established as an open platform for any European university or European research institute that are actively involved in experimental nuclear education, training and competence building. The ENEEP founding members will be all five partners of this project, i.e. STU, CTU, TU Wien, JSI, and BME. All partners are heavily involved in experimental nuclear education, training and competence building. Four project partners, namely STU, CTU, TU Wien and BME, established in 2003 the Eugene Wigner course which put together three research nuclear reactors and offered experimental reactor courses for master students in nuclear engineering using these reactors. The main goal will be achieved through specific objectives of the project. Each specific objective will be achieved through the implementation of particular or multiple work packages and are strongly interconnected. As a result, the ENEEP will be established as well as its education and training capabilities will be demonstrated. The project will contribute to the expected impacts set out in the work programme, under the relevant topic - NFRP-2018-7: Availability and use of research infrastructures for education, training and competence building. The proposed project will enable the establishment of the ENEEP platform, aimed at becoming the leading European platform offering experimental nuclear education and training activities. Based on the experience from the last years, we expect that the number of students and trainees during five years after the project end will reach up to 1300 persons.

Keywords: eneep,platform,training,education,competence building,nuclear
ENgineering COMPASS (ENCOMPASS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Spain,Ireland,Germany,Italy,Belgium,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Photonics Laser-based production (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2020-02-29
Duration (months): 41.0
Total project cost (EUR): 4040371.25
EU funding (EUR): 4040371.25
Participants: 11
Project status: CLOSED

The ENCOMPASS project principally aims to create a fully digital integrated design decision support (IDDS) system to cover the whole manufacturing chain for a laser powder bed fusion (L-PBF) process encompassing all individual processes within in. The ENCOMPASS concept takes a comprehensive view of the L-PBF process chain through synergising and optimising the key stages. The integration at digital level enables numerous synergies between the steps in the process chain and in addition, the steps themselves are being optimised to improve the capability and efficiency of the overall manufacturing chain. ENCOMPASS addresses the three key steps in the process chain: component design, build process, and post-build process steps (post-processing and inspection). The links between these stages are being addressed by the following five interrelations: 1. Between the design process and both the build and post-build processes in terms of manufacturing constraints / considerations to optimise overall component design 2. Between the design process and build process component-specific L-PBF scanning strategies and parameters to optimise processing and reduce downstream processing 3. Between the design process and the build and post-build processes in terms of adding targeted feature quality tracking to the continuous quality monitoring throughout the process chain 4. Between the build and post-build processes by using build specific processing strategies and adaptation based on actual quality monitoring data (for inspection and post-processing) 5. Between all stages and the data management system with the integrated design decision support (IDDS) system By considering the entire AM process chain, rather than the AM machine in isolation, ENCOMPASS will integrate process decision making tools and produce substantial increases in AM productivity, with clear reductions in change over times and re-design, along with increased ‘right-first time’, leading to overall reductions in production costs, materials wastage, and over-processing. This will lead to higher economic and environmental sustainability of manufacturing, and re-inforce the EU’s position in industrial leadership in laser based AM.
ONLINE PORTAL FOR E-LEARNING AND SUPPORTING SOCIAL INCLUSION OF PEOPLE WITH DYSLEXIA (LITERACY)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for Health, Ageing Well, Inclusion and Governance
Action type: Collaborative project
Countries involved: Spain,Czechia,Austria,Hungary,Israel
Call:  (FP7-ICT-2011-7, 2011)
Start date: 2012-03-01
End date: 2015-02-28
Duration (months): 36.0
Total project cost (EUR): 3331635.0
EU funding (EUR): 2570000.0
Participants: 8
Project status: CLOSED

The objective of the LITERACY project is to create an advanced online portal, which will aid both dyslexic youths and adults. The Portal will provide personalized e-learning programs, useful tools and methods for helping people with dyslexia to improve their abilities in reading, writing and then function in society. The Portal will also provide entry to an accessible online community of peers. Employing novel modelling algorithms the system will assess the users' level of literacy and particular strengths/weaknesses in learning. It will on this basis automatically adjust to provide the required personalized services for that specific user. A specialized interface and Community Zone with programs and services will improve users' skills, drastically simplifying otherwise complicated tasks. This will be done by utilizing advanced novel tools which will be integrated with both existing and adapted ICT tools and hardware. Dyslexic users will be able to access this portal independently and receive real-time feedback on their progress. The Portal will be based on input of content by educational professionals in both EU and Associate countries, providing an array of levels and in several languages. The Portal will empower and support dyslexic youth and adults to help themselves succeed in literacy related achievements, ultimately strengthening their success and inclusion in school, university, work and their social lives.

Keywords: dyslexia,learning disabilities,personalised e-learning,multi-dimensional statistical models,personalised interface,online assessment tools,assistive technologies,special education