Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modern numerical methods for high-fidelity simulation of geohazards (MONUGEO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,China,Australia,Korea, Republic of,United Kingdom,Macao,France,Spain,Ukraine,Poland,Netherlands,Italy,Germany,Nepal,Japan
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 1285371.43
EU funding (EUR): 1269600.0
Participants: 15
Project status: SIGNED

Geohazards, such as rock avalanches, landslides and debris flows, are commonly recoganized as the slow-to-rapid gravitationally-driven processes that typically occur in mountain regions, such as Alps in Europe, Himalaya in Asia, Rocky in North Americas and Snowy in Australia, possessing potential hazards societies. With the advancement of computer science, numerical simulations of geohazards have become crucial in the modern geomechanics and geotechnical engineering. The fragmentation of current research into local national projects often falls short in comprehensive understanding of the evolution mechanisms. This gap results in a grey area in modern numerical methods for high-fidelity simulations, limiting accessibility for both scientific researchers and engineering practitioners. MONUGEO brings together the complementary expertise of our consortium members to develop a better understanding of triggering initiation, run-out and deposition (and/or interaction with protective obstacles) processes, and in turn to produce the ground-breaking numerical tools for the high-fidelity predictions. Our international and interdisciplinary consortium will also prefer to an integrated research approach, involving laboratory experiments, scaled centrifuge physics modelling tests, and region-scale application with geological survey. This integrated methodology will serve to validate our developed computing paradigms and numerical toolbox, and to apply them to realistic scenario.

Keywords: mountain geohazards rock avalanches landslides modern numerical methods multiscale simulations
Integrated Models for the Development and Assessment of High Impact Chemicals and Materials (INSIGHT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Finland,Cyprus,Greece,United States,Korea, Republic of,Brazil,Belgium,Spain,Slovenia,Germany,Switzerland,Australia,United Kingdom,Netherlands,Luxembourg,Austria,Italy
Call: Integrated approach for impact assessment of safe and sustainable chemicals and materials (RIA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 4130318.75
EU funding (EUR): 4130318.75
Participants: 21
Project status: SIGNED

Safe and sustainable by design (SSbD) chemicals and materials are crucial to address the challenges of modern society. However, lack of stakeholders’ coordination, limited access to relevant data, and absence of standardised methods have thus far hampered the emergence of a comprehensive approach to SSbD. INSIGHT will overcome these challenges by developing an innovative framework for mechanistic impact assessment of chemicals/materials. The INSIGHT framework will consist of a multi-layered approach that integrates data, models, and impact outcome pathway (IOP) graphs. INSIGHT will also provide curated and user-friendly FAIR data and computational models/workflows. INSIGHT aims to foster a paradigm shift in the assessment of sustainability and safety of chemicals and materials, from a fragmented situation to a holistic and integrated approach. INSIGHT will provide decision maps as a part of its integrated framework to guide users through the decision-making process, aiding them in evaluating the social, economic, health and environmental impacts of chemicals/materials in a more efficient and comprehensive manner. The INSIGHT project is fully aligned with the EU principles of safety and sustainability and the European Green Deal. INSIGHT will support the development of policies in the areas of neutrality, biodiversity protection, public health, and circular economy, thus aiding the development of a dynamic economy respecting planet Earth as a whole, avoiding harm to humans and the environment. By democratising the use of cutting-edge AI methods to SSbD, INSIGHT will drive innovation towards a digital, circular, climate-neutral and sustainable economy. INSIGHT will help the industry to optimise development and production of chemicals/materials and derived products, support regulators and policymakers in informed decision-making towards safer and more sustainable society, and pave the way for a comprehensive approach to SSbD.

Keywords: ssbd,knowledge graph,fair data,models integration,pfas,2d materials,antimicrobial materials,ai based modelling,mechanistic modelling,aop
The molecular foundation of cervical mucus plug protection from intrauterine infection during pregnancy (MUCPLUG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1999461.0
EU funding (EUR): 1999461.0
Participants: 1
Project status: SIGNED

During pregnancy, the cervix undergoes dramatic remodelling characterised by the emergence of mucus secreting goblet cells (GCs) that generate a cervical mucus plug (CMP) in the cervical canal. The CMP is thought to act as a barrier that is crucial for maintaining uterine sterility, thereby protecting the foetus from ascending bacterial infections. However, this view is based on relatively little experimental evidence and our knowledge of specific endogenous or exogenous factors that may regulate cervical GC functions and CMP properties is virtually non-existent. This knowledge gap has significant clinical implications, as preterm birth is a common consequence of intrauterine bacterial infections and is associated with up to 0.6 million annual infant deaths. Over the previous decade, significant research efforts have been made to dissect GC and mucus protective functions in the gut and lungs, while the female reproductive tract has been largely neglected. Fortuitously, much of the knowledge and tools developed by this research can be repurposed to study cervical GCs and the CMP. These include transgenic mice with tagged cervical GCs, null mutant mouse models, targeted mucus biochemical and barrier property analytics, ex vivo mucosal methodologies and large-scale mutagenesis libraries of bacteria that can cause intrauterine infection. In this proposal we will repurpose these tools to: 1) Define GC and CMP gestational dynamics in pre-clinal mouse models; 2) Identify causal links between endogenous and exogenous factors that regulate GC and CMP functions; 3) Screen for bacterial virulence factors associated with breach of the CMP during pregnancy; 4) Isolate CMP alterations associated with human preterm birth. Addressing these aims will provide new insights into GC and mucus biology, host-pathogen interactions and develop a deeper understanding of female reproductive biology that can applied to the development of precision interventions to reduce infant mortality

Keywords: pregnancy,preterm birth,goblet cell,mucus,intrauterine infection
A Coupled Finite Element Framework for Multi-Physics Environmental Flows (HYDROCOUPLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 2
Project status: CLOSED

HYDROCOUPLE proposes to develop (1) a new coupled finite element (FE) method for environmental flows, (2) goal-oriented adaptive mesh refinement strategies, and (3) to apply the new techniques to physical watersheds for verification of its capabilities as well as to demonstrate these. The project is a collaboration between three researchers, the applicant Eirik Valseth (currently at The University of Texas at Austin), Prof. Kent-Andre Mardal (The University of Oslo) and Prof. Ethan Kubatko (The Ohio State University). Many current approximation techniques for multiphysics phenomena, where two or more models (partial differential equations) govern the physics, focuses on the approximation of these as separate phenomena and prescribe appropriate interface conditions to exchange information between the models. Recent attention has been given to monolithically coupled methods (Kuchta et al. 2021), where all models are approximated simultaneously thanks to careful algorithm design and numerical analysis. HYDROCOUPLE will extend the theory of these monolithic coupling schemes to environmental flow problems and develop a FE framework for their corresponding numerical approximation. This developed framework can subsequently be applied in flood prediction and hydropower production planning as the models in environmental flows govern both overland and riverine flows which are critical in both applications. HYDROCOUPLE will also develop mesh-adaptive refinement techniques based on goal-oriented error estimation to ensure the high fidelity of its numerical approximations. Finally, the proposed framework will be verified against available data for existing watersheds to demonstrate its efficiency and accuracy to end users in industry and government. Working in the Section of Mechanics at the Department of Mathematics with a world renowned scientist will provide a perfect setting to integrate my knowledge and start my research career in Europe.

Keywords: finite element methods,hydraulic flows,multiphysics,flood prediction,hydropower production prediction,
Bioengineering novel post-harvest traits in Brassica crops (Post-Harvest-Boost)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-02-01
End date: 2027-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Food security and nutritious diets for all are major challenges for a rapidly growing global population and for healthy aging. To feed the global population in the coming years, the production of agricultural crops has to sharply increase, yet up to 50% of harvested vegetables are currently wasted along the supply chain from growers to retailers to consumers. Food waste also produces greenhouse gases that contribute to climate change and their diminishing nutrition upon storage compromise healthy diets. Especially leafy vegetable crops have relatively short-shelf lives: after harvest they rapidly lose nutritional value, suffer from dehydration, and often end up rotting as diseases strike. Thus, there are urgent public health, net zero and economic needs to improve the post-harvest shelf-lives of vegetables. In our ERC-CoG project UbRegulate, we discovered that post-harvest tissues experience extensive changes in their ability to launch immune responses. Further study showed that after harvest, Brassica crops such as cabbage, broccoli and salad rocket, undergo dramatic cellular changes to cope with post-harvest stresses. These findings demonstrate that post-harvest crops respond differently to their environment compared to unharvested crops. Thus, bioengineering harvest-inducible traits – rather than constitutive traits – to improve post-harvest health and longevity is preferable and avoids deleterious side-effects during the on-soil growth phase. Here, we will provide proof-of-concept that synthetic bioengineering approaches can introduce novel traits specifically in harvested tissues. By using synthetic gene circuits, we will specifically express desirable traits only after harvest to extend the healthy shelf-lives of Brassica crops. Improving post-harvest longevity, quality and health of crops will result in large financial gains, food security and dramatically reduce food waste for growers, retailers and consumers.
Innovative mucus secretion stimulation for inflammation control in Inflammatory Bowel Disease (MucusIBD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-10-01
End date: 2026-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Inflammatory bowel diseases (IBDs), such as Crohn’s disease and ulcerative colitis, are chronic, debilitating conditions affecting millions worldwide. There is currently no cure for IBD, only treatments aimed at inducing long lasting remission. These treatment options act mainly by inhibiting the patient’s immune system, leaving patients immunocompromised, and come with a high annual direct cost. Even with advanced treatment, most IBD patients will require surgery during their lifetimes. Thus, more affordable treatment option which are not focused on immune suppression are needed. While the etiology of IBDs is not clear, it is thought that breakdown of gut barrier function is a major driver of chronic intestinal inflammation. Indeed, penetrance of luminal microbes into the mucus layer which covers the intestinal epithelium is a hallmark of IBDs. This penetrance and contact of microbes with the host’s immune system drives a proinflammatory response and prevents tissue healing. While performing our ERC-funded research project we found a way to induce excess intestinal mucus secretion in mice. We found this excess mucus secretion protected mice from development of colitis in a model of IBD. We also uncovered the mechanism which controls intestinal mucus secretion and discovered a cheap and reproducible way to pharmacologically induce excess mucus secretion using a bile acid. Our goal is to determine whether pharmacologically inducing intestinal mucus production in preclinical mouse models of IBD can induce and sustain remission. The project's methodology encompasses preclinical trials utilizing three distinct mouse models to rigorously test the efficacy and safety of our innovation. A comprehensive market analysis, informed by stakeholders including healthcare professionals and patient advocacy groups, will guide the development process, ensuring the therapeutic approach meets the real-world needs of IBD patients.
European Partnership One Health AntiMicrobial Resistance (OHAMR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: COFUND actions
Partnership: One-Health Anti-Microbial Resistance (co-funded)
Countries involved: Sweden,France,Estonia,Italy,Portugal,Germany,Belgium,Poland,Lithuania,Denmark,Spain,Austria,Israel,Moldova, Republic of,Finland,United Kingdom,Ireland,Türkiye,Latvia,Czechia,Bulgaria,Netherlands,Malta,South Africa,Norway,United States,Switzerland,Canada,Hungary,Slovakia
Call: European Partnership: One Health Anti-Microbial Resistance (HORIZON-HLTH-2024-DISEASE-09, 2024)
Start date: 2025-06-01
End date: 2035-05-31
Duration (months): 120.0
Total project cost (EUR): 253440336.79
EU funding (EUR): 75065263.92
Participants: 53
Project status: SIGNED

Antimicrobial resistance (AMR) is a global health challenge with an estimated 67% increase in global deaths attributable to AMR by 2050. The European Partnership One Health AMR (EUP OHAMR) is aiming to reduce the burden of AMR with an integrated One Health (OH) approach, recognising that human, animal and plant health are interdependent and interlinked with the environment. The partnership will boost AMR research and innovation (R&I) addressing the current knowledge gaps with the aim to improve surveillance of resistant pathogens and provide better diagnostics and more effective treatments of drug-resistant infections. It will support implementation research on prevention measures reducing the use of antimicrobials and spread of AMR and launch an ambitious work programme of joint activities to coordinate R&I investments, facilitate the use and re-use of R&I data, strengthen AMR R&I capacities and facilitate both knowledge translation and uptake of research results and innovations by industry, society, and policy makers. The EUP OHAMR builds on the long-standing collaboration of the partners from the Joint Programme Initiative on AMR (JPIAMR) but with a bigger ambition and a broader scope. The partnership consists of 53 partners from 30 countries from the European Union (EU) and beyond. With active engagement of key stakeholders across the AMR landscape, the partnership will strengthen European and global synergies through alignment of research priorities, policies, and investments. Furthermore, EUP OHAMR will support multisectoral and multidisciplinary collaborations to break the existing silos in AMR research. It will result in increased knowledge and solutions and provide an evidence base for uptake into policy and practice to prevent and tackle AMR. Thus, the EUP OHAMR will deliver towards to the priorities set in the European One Health Action plan against AMR, thereby strengthening the European Research and Innovation Area ecosystem and contribute to making the EU a best-practice region on AMR.

Keywords: one health,research,prevention,therapeutics,diagnostics,implementation
Mitochondria-Inflammation crosstalk and EXercise-induced pathways in cachexIA (MIEXIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-08-31
Duration (months): 26.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Cancer cachexia (CC) affects 50-80% of patients with cancer and is characterized by accelerated loss of muscle mass, which is directly linked to reduced quality of life, treatment toxicity, and lower survival. With no pharmacological treatment options, key to improving life expectancy is to understand the molecular determinants of CC, however, these are poorly defined. Mitochondrial dysfunction and inflammation can cause muscle atrophy and are considered as emerging hallmarks of CC. Exercise is the most potent approach to improve mitochondrial and muscle function, and to reduce inflammation, yet, implementing it in CC is challenging because of fatigue and pain of patients with cancer. Elucidating the molecular underpinnings of exercise’s beneficial effects represents a major scientific challenge and an untapped opportunity for medical exploitation. In this regard, unpublished data from my host lab show that muscle protein levels of the mitochondrial (mt) RNA stabilizer LRPPRC (Leucine-rich PPR motif-containing protein) are induced upon exercise and reduced in cachectic muscles. Thus, mtRNA metabolism could be a new target for CC. mtRNA metabolism is key to maintain levels of mtDNA-encoded proteins to promote mitochondrial function. Yet LRPPRC´s role in muscle mitochondrial function and CC is unexplored. I hypothesize that reduced LRPPRC is key in CC-associated muscle mitochondrial dysfunction and inflammation. Stimulation of LRPPRC could promote exercise-like benefits, establishing a new pharmacological target for CC. I aim to determine the molecular link between mitochondrial dysfunction, inflammation, and muscle atrophy in preclinical CC models and patients with CC. I will unravel the molecular pathways involved in LRRPRC’s exercise-induced effects and I will appraise LRPPRC’s therapeutic potential in CC. Results have the potential to provide crucial insights on the molecular events underlying CC and likely identify new pharmacological strategies to tackle it.

Keywords: mitochondria,inflammation,exercise,mtrna metabolism,cancer cachexia
CO2 Removal. The Technopolitics of Negative Emissions Technologies (CORE TENET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-01
End date: 2028-07-31
Duration (months): 36.0
Total project cost (EUR): 289407.84
EU funding (EUR): 289407.84
Participants: 2
Project status: SIGNED

The project analyzes the Technopolitics of Negative Emissions Technologies (NETs) in global climate action. It is a sociological project inspired by interdisciplinary approaches from Science and Technology Studies. NETs should mitigate global heating by removing CO2 from the atmosphere. They not only offset residual emissions to achieve “net-zero” but promise to contribute to “net-negative” emissions by removing enough CO2 from the atmosphere to reduce warming to 1.5 or 2°C after a temperature overshoot. Though many NETs are not yet fully developed, prohibitively costly, and hard to scale up, they already figure prominently in climate scenarios by the Intergovernmental Panel on Climate Change (IPCC). This tension between assigned role and current reality of NETs calls for an inquiry that looks at NETs as “socio-technical imaginaries” (Jassanoff) that shape and are shaped by “imagined futures” (Beckert). Drawing on qualitative social research methods, the project will in a first step look at the framing of NETs in climate scenarios and ask if and how they justify the delay of climate action. In a second step, the project will analyze the development of NETs in oil and gas companies. It will ask how NETs allow the companies to envision a future where they can continue their current business model despite stricter climate regulation. The project will thus analyze how the mutual reinforcement between calculative devices (scenarios) and technical devices (NETs) turn NETs into attractive climate action options. The “technopolitics” lens the project adopts stresses that these seemingly innocuous devices embody and effectuate political stances that have significant consequences for the direction of climate politics. This perspective helps to engender a reflexive discussion on NETs that not only narrowly focuses on the cost-efficiency of carbon removal but also on their effectivity for climate mitigation and their potential contribution to questions of equity.

Keywords: critical theory technopolitics climate change environmental sociology politics of anticipation fossil fuels oil and gas companies carbon imagined futures calculative devices,climate justice