Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tuning brain fate through modulation of chromatin remodelling (SWItchFate)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2009474.0
EU funding (EUR): 2009474.0
Participants: 1
Project status: SIGNED

The mammalian SWI/SNF chromatin remodellers, the BAF complexes, are critical regulators of gene expression by modulating the accessibility of regulatory regions, especially of cell identity genes. Their importance for cellular maintenance and differentiation is emphasised by the fact that they are frequently associated with disease. Mutations in genes encoding BAF subunits are found in over 20% of cancers and are causative for neurodevelopmental disorders (NDD). The prevalence for specific NDD with unique clinical features depends on the mutant subunit. The molecular changes leading to the disease phenotypes are largely unresolved. The functions of BAF complexes and specific subunits during human brain development are also still unclear. SWItchFate thus aims to systematically identify the role of individual BAF subunits and their mutations in brain development and abnormalities. To this end, isogenic wild type, mutant and engineered human induced pluripotent stem cell (hiPSC)-derived cerebral organoids will be used in combination with various bulk and single-cell epigenomics and proteomics tools. SWItchFate will investigate gene regulatory mechanisms altered during brain development with CRISPR/Cas-based loss-of-function screens for all BAF subunits. Using protein degradation tools targeting specific BAF subunits, SWItchFate will pinpoint vulnerable processes and adaptation mechanisms. In addition, cell type- and BAF subtype-specific composition, interaction partners and target sites along brain development will be mapped to decipher BAF-dependent gene regulatory networks. Finally, the molecular changes in BAF mutation-induced NDD that cause the phenotypic changes in patients will be examined and conserved mechanisms across different genotypes will be deciphered using patient-derived hiPSC. Thus, SWItchFate will decode the regulatory functions of BAF complexes in the context of cell fate decisions in development and disease, paving the way for new therapeutics.

Keywords: brain development,cerebral organoids,neurodevelopmental disorders,baf complexes,swi snf,chromatin remodelling,cell fate control
Enabling Homomorphic Encryption of Deep Neural Network Models and Datasets in Production Environments (HomE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2680195.0
EU funding (EUR): 2680195.0
Participants: 1
Project status: SIGNED

Deep learning (DL) is widely used to solve classification problems previously unchallenged, such as face recognition, and presents clear use cases for privacy requirements. Homomorphic encryption (HE) enables operations upon encrypted data, at the expense of vast data size increase. RAM sizes currently limit the use of HE on DL to severely reduced use cases. Recently emerged persistent memory technology (PMEM) offers larger-than-ever RAM spaces, but its performance is far from that of customary DRAM technologies. This project aims at sparking a new class of system architectures for encrypted DL workloads, by eliminating or dramatically reducing data movements across memory/storage hierarchies and network, supported by PMEM technology, overcoming its current severe performance limitations. HomE intends to be a first-time enabler for the encrypted execution of large models that do not fit in DRAM footprints to execute local to accelerators, hundreds of DL models to run simultaneously, and large datasets to be run at high resolution and accuracy. Targeting these ground-breaking goals, HomE enters into unexplored field resulting from the innovative convergence of several disciplines, where wide-ranging research is required in order to assess current and future feasibility. Its main challenge is to develop methodology capable of breaking through the existing software and hardware limitations. HomE proposes a holistic approach yielding highly impactful outcomes that include novel comprehensive performance characterisation, innovative optimisations upon current technology, and pioneering hardware proposals. HomE can spawn a paradigm shift that will revolutionise the convergence of the machine learning and cryptography disciplines, filling a gap of knowledge and opening new horizons such as DL training on HE, currently too demanding even for DRAM. HomE, based on solid evidence, will unveil the great unknown of whether PMEM is a practical enabler for encrypted DL workloads.

Keywords: deep learning inference heterogeneous memory systems high performance computing homomorphic encryption persistent memory
EMpowering CCIs to boost systemic INNOvation for sustainable climate transition (EMCCINNO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: France,Belgium,Spain,Hungary,Portugal,Germany
Call: Cultural and creative industries for a sustainable climate transition (HORIZON-CL2-2024-HERITAGE-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 3097491.65
EU funding (EUR): 2987798.6
Participants: 13
Project status: SIGNED

Climate change is a pressing threat, and Europe faces a significant challenge to address it urgently. The EU has set ambitious climate goals, such as the Green Deal's target to reduce net greenhouse gas emissions by at least 55% by 2030. But this challenge also involves deep social and cultural transformations. Within this context, the Cultural and Creative Industries (CCIs) play a crucial role in the climate transition by raising awareness, changing imaginaries and contributing to economic sustainability and innovation. However, CCIs, particularly small and medium-sized organisations, are vulnerable due to limited resources and fragmentation, emphasized by the negative consequences of climate change. They urgently require tested tools to enhance their capacity for rapid adaptation and making meaningful contributions to the climate transition. Cultural and Artistic Social Enterprises within CCIs, work in close proximity to citizens and cooperation with local actors, which makes them uniquely able to identify emerging social and environmental demands. Based on this citizen and creative-driven knowledge, they propose innovative and creative solutions, having a unique potential of influencing values and attitudes and inspiring blueprints within the sector and beyond. The EMCCINNO project (EMpowering CCIs to boost systemic INNOvation for sustainable climate transition) brings together the fields of CCIs, climate transition, and social enterprises. It aims to refine, test, validate and scale sustainable business models, implementing them into prototypes for real-world impact within small and medium-sized CCIs. Focusing on cultural and artistic social enterprises, the project involves five diverse organisations from five EU Member States that will design, and test prototypes based on their sustainability transition needs, supported by researchers throughout the process, thus contributing to the EU's climate goals.

Keywords: culture and creative industries,social enterprises,sustainable climate transition,business models,arts and culture
O-Glc-NAc modifications of RNA-binding proteins (OMRP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Slovenia,Croatia,United Kingdom
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-07-01
End date: 2025-08-31
Duration (months): 26.0
Total project cost (EUR): 168522.64
EU funding (EUR): 168522.64
Participants: 3
Project status: SIGNED

O-GlcNAcylation is a post-translational dynamic modification of proteins that is becoming more widely recognized as a modification that can protect proteins from pathological aggregation in neurodegenerative diseases. However, it is unknown how this modification influences the RNA binding properties of the protein and its function. In the proposed project I will study the O-Glc-NAcylation of RNA-binding proteins (RBPs) associated with amyotrophic lateral sclerosis (ALS), and its effects on the RNA binding properties and thereby on the regulation of RNA processing. I will find O-GlcNAcylation sites of TDP-43, Fused-in-sarcoma (FUS), Ewing sarcoma protein (EWS), and TATA-box binding protein associated factor 15 (TAF15) and I will assess the increased amounts of modification after stimulation of the cells with high glucose or with O-Glc-NAcase inhibitor. I will study if their RNA interaction profiles change with increasing amounts of O-Glc-NAc modifications in differentiated cortical neurons. Later, I plan to implement in the company, a mass spectrometry method adapted to analyse the ALS-liked RBPs proteins, which will help the glycoscience community. This project will expand our understanding of the molecular mechanism of transcription regulation through protein O-Glc-NAcylation and can provide the necessary knowledge to understand ALS-related proteinopathies.

Keywords: o glc nac,o glc nacylation,rbps,als,rna interactions,rna splicing,iclip,glycosylation
Safety assUraNce fRamework for connected, automated mobIlity SystEms (SUNRISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Spain,Germany,Sweden,France,Netherlands,Belgium,Austria,Italy,Hungary,Croatia,Türkiye,United States,United Kingdom,Greece
Call: Common approaches for the safety validation of CCAM systems (CCAM Partnership) (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 13087426.25
EU funding (EUR): 13087426.0
Participants: 29
Project status: SIGNED

Safety assurance of Cooperative, Connected, and Automated Mobility (CCAM) technologies and systems is a crucial factor for their successful adoption in society, yet it remains to be a significant challenge. CCAM must prove to be safe and reliable in every possible driving scenario. It is already acknowledged that for higher levels of automation the validation of these systems by real test-driving would be infeasible by conventional methods. Furthermore, certification initiatives worldwide struggle to define a harmonized approach to enable massive deployment of highly automated vehicles. Building from HEADSTART and other initiatives, SUNRISE (Safety assUraNce fRamework for connected, automated mobIlity SystEms) will develop and demonstrate a commonly accepted, extensible Safety Assurance Framework for the test and safety validation of a varied scope of CCAM systems. This will be achieved by: 1) Bringing the needs of heterogeneous CCAM use cases; 2) Defining a scenario-based database framework that will broaden the HEADSTART methodology; 3) Holistically addressing the CCAM test scenario generation; 4) preparing the required tools for comprehensive testing (virtual and physical), taking into account robustness, scalability, interoperability, quality and standardization; 5) integrating functional safety and cybersecurity; 6)involving the use cases from the initial stages, acting as a guiding principle within the project. The project will define, implement and demonstrate the building blocks of this Safety Assurance Framework: harmonized and scalable safety assessment methodologies, procedures and metrics taylored for use cases, a federated European Scenario Database framework and its necessary data interfaces, a commonly agreed simulation framework including tools and interfaces. SUNRISE will work closely with CCAM stakeholders as policy makers, regulators, consumer testing, user associations and all relevant stakeholders.

Keywords: safety,validation,verification,ccam,automation,cooperative systems,testing,simulation
Cryptogam biodiversity dynamics under climate change in the Arctic and Antarctic poles (BIPOLAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-05-01
End date: 2027-10-31
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 3
Project status: SIGNED

Earth’s polar regions are warming at unprecedented rates. Antarctica is experiencing rapid regional warming, and the Arctic has warmed up to four times the global average. In response, vascular plants have experienced shifts in species’ abundance and distribution. Polar regions host large richness of cryptogam species (bryophytes and lichens), which are essential ecosystem regulators that contribute to nutrient cycling, soil moisture and energy balance. Despite these crucial roles and expectations that cryptogams can be seriously affected by climate change, taxonomical challenges hinder our understanding of their current trends. BIPOLAR will tackle this knowledge gap by quantifying polar cryptogams’ climatic niches to understand their potential for climate change adaptation. Both poles contain similar habitats shaped by extreme conditions, but the Arctic is warming more rapidly than Antarctica, and ecological processes have been more extensively documented there. BIPOLAR is an interdisciplinary project that will provide a window into the future of Antarctic cryptogams by using the Arctic as a sentinel region via bipolar cryptogam species (i.e., present at the two poles). BIPOLAR will combine a variety of methods and data (i.e., palaeoecology, open-access datasets, fieldwork and Bayesian statistics), and employ historical and current data to inform future projections. The three objectives of BIPOLAR are: 1) Compiling and standardising bipolar cryptogam data from multiple sources, 2) Quantifying past, present and future macro- and micro-climatic niches, and identifying winner and loser cryptogam species, and 3) Validating species occurrence and climate data through fieldwork. This research will provide a foundation for conservation as these regions become progressively more ice- and snow-free, while strengthening currently fragmented Arctic and Antarctic research links and bringing together the polar research community.

Keywords: climate change,bryophytes,lichens,polar regions,arctic,antarctic,climatic niches,conservation,cryptogams
The European Data Union: European Security Integration through Database Interoperability (DATAUNION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1499750.0
EU funding (EUR): 1499750.0
Participants: 1
Project status: SIGNED

EU policy-makers are constructing a European Data Union. Its ambition is database interoperability with information stored in autonomous databases becoming interconnected and available to authorities across Europe. However, database interoperability is not a mere technical fix, but an inherently political process. In the design of existing and future databases lays the foundations of future European security integration and the redefinition of some of its core dimensions: security practices, institutional governance, and relation to fundamental rights. Despite its political importance, little is known about how database interoperability actually structures and re-arranges modern power relations. The construction of the European Data Union, as one of the largest real-life experiments of database interoperability, represents a fascinating opportunity to unpack this issue. Hence, the DATAUNION project will pursue four objectives: (1) Theorizing the socio-material practices that underpin database interoperability through the innovative notion of security tinkering, defined as the processes through which conflicts and solutions related to database interoperability are addressed, dodged or solved; (2) Developing a ground-breaking multi-modal approach bringing Critical Making Practices to the study of security practices in order to retrace how database interoperability is implemented on the ground; (3) Delivering new empirical knowledge on the processes and challenges of all three main European interoperability initiatives, and how they shape the future of European security integration; and (4) Evaluating the ethico-political implications of the construction of the European Data Union. Overall, the DATAUNION project will transform Critical Security Studies’ conceptual and methodological repertoire and will have a major impact on International Relations’ and EU Studies’ understanding of the role of digital technologies in European security integration.

Keywords: critical security studies international political sociology area of freedom,security and justice europol eu lisa
AN ELECTRON BEAMLINE AT THE European-XFEL (ELBEX)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,United Kingdom,Spain
Call: Consolidation of the RI landscape – Individual support for evolution and long-term sustainability of pan-European research infrastructures (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 5309225.0
EU funding (EUR): 4247380.0
Participants: 5
Project status: SIGNED

One of the highlights of the European research infrastructure landscape is the world's most powerful X-ray-laser, the European XFEL. The ELBEX (Extracted Lepton Beam at the European XFEL) proposal builds on this strength and will set up new opportunities for European scientists and innovators, by providing an extracted high energy electron beam for experiments. With ELBEX we propose a pathfinder project to demonstrate the feasibility of such a facility at the European XFEL. This unique new possibility would strengthen the global competitiveness of the European Research Area and create opportunities for new user groups. The high energy, high charge density and excellent quality of the electron beam, if brought into interaction with a strong laser beam, opens up the study of a range of scientific topics, most prominently, of strong field Quantum Electrodynamics (QED). For the first time, the Schwinger limit for the electromagnetic field strength, at which non-perturbative QED effects become relevant, could be reached experimentally in this facility. Studying the particles created in the photon beam dump opens up the possibility to search for feebly interacting particles, complementing current or planned experiments like FASER II or SHiP. In addition, the electron beam itself is at the centre of a range of highly relevant and ambitious experiments in the area of accelerator science and detector science. Within the ELBEX project, the installation of a facility to extract an electron beam from the European XFEL using a fast kicker magnet and to transport it into a multi-purpose experimental area will be prepared. On the condition that a positive decision by the European XFEL council is reached to grant an extended 12-week XFEL shutdown, the installation of the ELBEX facility is an option.

Keywords: qed,european xfel,desy,strong field qed,bsm physics,feebly interacting particle searches,beam dump experiments,electron beam facility
Renewable Energies System for Cities (RES4CITY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Portugal,Spain,Denmark,France,Sweden,Belgium,Switzerland
Call: Sustainability and educational aspects for renewable energy and renewable fuel technologies (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2499933.75
EU funding (EUR): 2499933.75
Participants: 18
Project status: SIGNED

A carbon-neutral European Union by 2050 is an ambitious target that presents technical and societal challenges. While technical research is advancing rapidly to reach a net-zero target, the overall skillsets of the working force are lagging behind in understanding, employing and mastering sustainable technologies for the business models. Therefore, the RES4City project envisions a codesigned educational framework for upskilling the workforce to integrate, influence and combine the current sustainability best practices for renewable energies and fuel technologies. The main pathways to reach this objective are the definition of microprogrammes, the development of serious games for learning and training, the establishment of the industry-academy programme and the analysis of industry-based case studies for the fast track towards sustainability and circular economy. In addition, the program will focus on developing and testing the program in coordination with different stakeholders such as public governance, industry, NGOs, and citizens. Within the program, a separate task on inclusivity and gender balance will promote and ensure the participation of a representative cohort of students. The thematic area selected for the project is the cities. The link between these sectors is intrinsically defined, and they have extensive unexploited opportunities for renewable energy deployment and fossil fuel substitution to improve their sustainability and the massive potential of circularity implementation.

Keywords: sustainable business models,smart city,decarbonisation,positive energy district,sustainability,circular economy,codesign,open innovation,educational framework,