Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigating manual dexterity in healthy people and patients after stroke using multi-locus transcranial magnetic stimulation (DEXTSTIM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: SIGNED

Upper limb dexterity is a unique human ability commonly compromised by stroke. I suggest that the upper limb dexterity after stroke may be compromised as a result of dysfunctional inhibition of the nearby muscles. In patients with mild motor impairment, this results in a lack of independent finger movements. In moderately-to-severely affected patients, the pathological synergies pose a major problem, affecting both proximal and distal joint movements. I will develop methods for evaluating the neural origins of the upper limb dexterity and its recovery after stroke, and for improving compromised motor control by transcranial magnetic stimulation (TMS) combined with electroencephalography, electromyography, and structural magnetic resonance imaging. I will perform multi-muscle cortical mapping using a novel neuromodulation technology, namely multi-locus TMS (mTMS), which allows stimulation of the nearby cortical targets with millisecond-scale delays between the pulses without moving the stimulator. This unique feature of mTMS will enable us to determine local excitation/inhibition (E/I) interactions among the cortical representations of different upper limb muscles. I will evaluate whether abnormal control of independent finger movements can be structurally and functionally explained in terms of the local E/I balance at the motor cortex. Then, I will utilize this information to develop unprecedented mTMS protocols that take into account the individual organization of the motor cortex and the possibility of its selective neuromodulation. In summary, I aim to demonstrate that (1) the intricate patterns of local E/I balance at the motor cortex are involved in the orchestration of muscle synergies, (2) the malfunctioning of this complex circuitry after stroke can lead to abnormal muscle-specific corticospinal excitability and impaired upper limb motor function, and (3) the local E/I balance can be manipulated with physiologically tuned multi-site mTMS protocols.

Keywords: transcranial magnetic stimulation tms,manual dexterity,stroke,upper limb,rehabilitation,motor cortex,excitation inhibition balance
Novel and systematically controlled surface modification on gastrointestinal corona formation (GUTCORONA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-08
End date: 2027-09-07
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

It is now well recognized that the protein corona formed on particles in physiological fluids has a strong impact on their performance in vivo. Therefore, this project aims to design and develop systematically controlled surface-modified nanoparticles for the formation and on-demand modification of protein corona in plasma or gastrointestinal environments. Firstly, the initial hypothesis is that the structure and composition of the corona formed on nanoparticles will be different with varying temperature-responsive surface functionality. Then, the second hypothesis is that using an alternating magnetic field (AMF) or near-infrared laser (NIR) as two different methods to activate the particles, these nanoparticles will act as internal heating sources generate localized high temperatures to modify the nature of the surface functionality, disrupting the corona structure, thereby enhancing cellular uptake and biological activity. Using this information, the nanoparticles will be optimized for use as theranostic agents, offering preferential accumulation, enhanced drug efficacy, and serving as contrast agents for in vivo and preclinical MRI/CT imaging. Through this Fellowship I will pass on my materials expertise to the host group while gaining new skills and experience at the intersection of colloid science and biology.

Keywords: gastrointestinal,nanoparticles,corona,surface modification,thermoresponsive
Aalborg: From Grey to Green – Europe’s Testbed for Sustainable Innovation (AAL-G2G)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: Other destinations
Action type: Recognition Prize
Countries involved: Denmark
Call: The European Capital of Innovation Awards (Rising) (HORIZON-EIC-2025-PRIZE-2, 2025)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

Aalborg: From Grey to Green – Europe’s Testbed for Sustainable Innovation Aalborg has undergone a profound transformation—from a heavy industrial hub into a dynamic innovation city, driving the green and digital transitions in Europe. With decades of strategic reinvention behind it, Aalborg now leads in three key domains: climate innovation, space technology, and future production. Central to this transformation are three flagship initiatives: • CO2Vision: A regional innovation platform of European relevance. Supported by the Just Transition Fund and Innovation Fund Denmark, CO2Vision brings together major industrial players—like Aalborg Portland, one of Europe’s top CO2 emitters—to pilot and scale breakthrough carbon capture and green fuel technologies. Our Vision - CO2Vision • Space Connect North: Born from Aalborg’s telecom legacy, this cluster now develops next-gen satellites, orbital robotics, and earth monitoring systems, making Aalborg a strategic contributor to the EU’s space infrastructure and autonomy. https://spaceconnectnorth.com/ • Future Production: A network of testbeds and maker labs enabling SMEs and corporates to co-create smart, automated, and sustainable manufacturing solutions—anchoring new jobs and tech capabilities in the region. AddSmart | European Digital Innovation Hubs Network

Keywords: sustainability,space,children s rights,co2,industry
Revealing the wiring rules of neural circuit assembly with spatiotemporally resolved molecular connectomics (SpaRC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

The human genome contains several thousand genes that play a key role in the development of the brain’s connectome, a precise assembly of neural connections with billions of neurons and trillions of synapses. How is genomic information translated into synapse-specific connectivity underlying behavior and cognition? Answering this fundamental question will provide important insights about the principles underlying nervous system development and is relevant for neurodevelopmental disorders such as autism. However, current approaches to measure neuronal connectivity have intrinsic limitations that prevent combined analysis of connected neurons, and their gene expression profiles at a scale that matches the complexity of the mammalian nervous system. Here I propose to develop a novel approach for massively parallel neural circuit tracing with barcoded rabies virus and 3D intact-tissue RNA-sequencing. This will permit a comprehensive understanding about neural network architecture via the large-scale measurement of molecular, cellular, and circuit-level mechanisms in the mouse brain. Compared to current efforts that require vast scientific resources to map synaptic connectivity among a few cells or small tissue volumes, my approach will enable routine measurements of connections among thousands of single neurons with molecular detail. Based on my expertise in in vivo barcoding I will conduct a longitudinal study to reveal the wiring rules underlying the spatiotemporal development of neural circuits from diverse neuron types in the mouse prefrontal cortex, a brain region that plays a key role in cognition. I will follow a cross-sectional approach to unravel the effects of distinct mutations on neuronal wiring in the prefrontal cortex in two mouse models of autism (Cntnap2-/-, Syngap1+/-). My work will provide an innovative experimental platform and provide mechanistic insights into the developmental algorithms that the genome uses to encode the connectome.

Keywords: molecular connectomics,cellular barcoding,spatial transcriptomics,neural circuit development
Unrevealing the mechanisms involved when producing biodiesel from waste oil using a combined experimental and theoretical methodology (UNPRECEDENTED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway,Portugal,Argentina
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 174800.0
EU funding (EUR): 174800.0
Participants: 3
Project status: SIGNED

40% reduction on emissions should be achieved by 2030 within EU with the outstanding goal for Europe to become the first climate neutral continent by 2050. These goals need to be reached without jeopardizing economic development and growth, and simultaneously fulfilling the UN goals for sustainability. One of the main contributors to climate change and global warming is emissions from our vehicles as these mainly use petroleum-based fuels. To address this, new approaches, methodologies, and technologies must be developed. Biodiesel is one option to substitute diesel; however, its production has been controversial since it requires the use of edible oils and thus creates conflicts with the production of food crops, making it less attractive. Because of this problem, newer technologies are being developed to treat lower quality nonedible oils. However, as yet, these are not economically viable. To address these problems, UNPRECEDENTED will focus on the use of waste oil. This new raw material has been tested experimentally with promising results. However, how the reaction is taking place and the steps involved is far from being understood. This lack of knowledge has a negative effect when selecting new technologies or testing new feedstocks. UNPRECEDENTED will use a combine methodology of experimental data and theoretical modelling (DFT based calculations) to study and fully comprehend the biodiesel production reaction. This methodology will permit a full understanding of the reactive steps involved, the reaction pathway that is followed as well as the energies involved in each reactive step. This methodology will assess for the conversion of waste oil in the presence of renewable alcohols to produce biodiesel when using new catalytic materials that are biobased, produce from renewable sources, and enriched with glycerol.

Keywords: dft modeling,reaction pathways,catalysts selection,biofuel production
Heritage Ecologies: culture, resilience and development in Island States (ECO-HERITAGES)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Malta
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-02-13
End date: 2025-02-12
Duration (months): 24.0
Total project cost (EUR): 161411.52
EU funding (EUR): 161411.52
Participants: 1
Project status: CLOSED

This proposal investigates the role of cultural heritages in promoting local economic development and social and environmental resiliences, in the context of Small Island States (SIS), Small Island and Developing States (SIDS) and Sub- National Island Jurisdictions (SNIJs) located in Europe, the African continent and in the Indian Ocean. Small islands are extremely vulnerable to climate change due to their small size and exposure to sea level rise, affecting their social and economic development. Crossing anthropology, heritage, environment, development and island studies, this research aims at integrating institutional heritagization processes and indigenous knowledge systems in actions for sustainable futures. This project will be hosted by the Islands and Small States Institute (ISSI) of the University of Malta, one of the few European entities in island studies and insular development, and supervised by Dr Stefano Moncada, specialist in development economics, climate change and sustainable development, and by Professors Lino Briguglio and Godfrey Baldacchino, world leading scholars in small states and islands studies. Addressing the challenges, at European and global level, of informing effective responses to mitigate social, economic and ecological consequences of climate change, this project will focus on the SIS of Malta, the SIDS of Comoros, Mauritius and Seychelles and the SNIJs of the French island territories of Reunion and Mayotte. Through an innovative interdisciplinary methodology, this research contributes with ethnography and cultural studies to sustainable development theories and brings socio-economic resilience analyses to heritage studies. This research will contribute, overall, to the role of Malta and of SIS in the UN actions for Sustainable Development, the EU Development and Cooperation actions and the Missions of the Horizon Europe 2021-2027 Framework.

Keywords: small island states,small island and developing states,sub national island jurisdictions,africa,europe,heritage,ethnography,indian ocean,mediterranean,ecology,sustainability,resilience
INNOVATIVE SOLUTIONS FOR SUSTAINABLE URBAN SOIL RESTORATION THROUGH LIVING LABS (URSOILL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Sweden,Netherlands,Spain,Germany,Belgium,Italy,Luxembourg,Greece
Call: Living Labs in urban areas for healthy soils (HORIZON-MISS-2024-SOIL-01, 2024)
Start date: 2025-09-01
End date: 2030-02-28
Duration (months): 54.0
Total project cost (EUR): 11999806.25
EU funding (EUR): 11999806.25
Participants: 34
Project status: SIGNED

In the face of rapid urbanization, with 70% of the global population expected to live in cities by 2050 , urban soils have become critical in providing essential ecosystem services (ESs) supporting healthy urban ecosystems. Among the ESs urban soils are essential for regulating the carbon and water cycles, mitigating flooding risk and heat islands, provide provisioning services, such as supporting biodiversity and urban food production, and enhancing urban green spaces that improve mental and physical well-being, and landscape aesthetics. Despite their importance, urban soils are often degraded by anthropogenic activities, including sealing, contamination with heavy metals, and compaction, which hinders their ability to provide ESs. This degradation poses risks to human and environmental health and worsens the effects of natural disasters like floods and heatwaves. URSOILL aims to address these challenges by establishing a network of five Living Labs (LLs) across EU cities to serve as interactive platforms where local stakeholders collaborate to co-create, test, and implement innovative solutions for urban soil restoration. Each LL will focus on improving soil health, enhancing ecosystem services, and promoting sustainable land management through the use of innovative technologies and nature-based solutions (NBSs). URSOILL will adopt a multi-actor, interdisciplinary approach, engaging different stakeholders. By placing urban communities at the core, the project ensures that the solutions developed are not only scientifically validated but also socially and economically viable. The co-creation of solutions in real-world settings will allow for effective knowledge transfer, fostering long-term cooperation and facilitating the replication of successful practices in other urban areas. By restoring urban soils and enhancing their capacity to deliver essential ESs, URSOILL will help cities become more climate-resilient, sustainable, and livable.

Keywords: soil health,living lab,urban,mission soil,ecosystem services,soil monitoring,stakeholder engagement,business models,real world testing,copernicus,soil reuse
Switching Polytypes and Symmetries by Discrete vdW Sliding (SlideTronics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2061775.0
EU funding (EUR): 2061775.0
Participants: 1
Project status: SIGNED

While the artificial design of pristine crystalline structures and the construction of dedicated periodic playgrounds for atoms and electrons in a solid have transformed our world, much is yet to be explored. I posit that the marvels of van der Waals polytypes should go much beyond and suggest that they offer a remarkable opportunity to rapidly, efficiently, and distinctively swap between numerous different crystals, symmetries, and dispersions at will. We have recently reported several new crystals made from identical 2D layers that differ only by their stacking symmetry. These perfectly commensurate and periodic di-atomic polytypes result in distinct electric potential steps and exclusive ladder-like polarizations owing to their various combinations of broken inversion and mirror symmetries. Our current research focus is mono-atomic polytypes that break both symmetries and offer further fundamental insight into the purely geometric impact of the atomic positions in the unit cell. Our preliminary experiments on graphitic polytypes detect novel internal polarizations, placing us in a great position to explore its interplay with superconductivity and orbital magnetization. The key challenge is to break the polytypes out of their commensurate meta-stable stacking and force the layers to slide at particular interfaces, only along armchair lattice orientation and for discrete inter-atomic distances. We have recently observed that such switching is possible using external electric fields, but only in the case of polar di-atomic bilayers. The swapping involves a thin incommensurate boundary wall encompassing a single stacking fault, which may slide rapidly in a super-lubric manner. Building on our ability to construct and distinguish adjacent polytypes, we aim to develop methods to efficiently switch between many distinctive polytypes and properties. With robust nano-meter and nano-second swapping capabilities, we envision ground-breaking SlideTronic technologies.

Keywords: van der waals interface,ferroelectricity,excitons in transition metal dichalcogenides,superlubricity
Assessing and improving access to health and social care SErvices for children RENdered vulnerable by Abuse (SERENA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: France,Germany,Denmark,Greece,Ireland,Portugal,United Kingdom,Austria,Sweden,Netherlands,Romania,Switzerland
Call: Access to health and care services for people in vulnerable situations (HORIZON-HLTH-2024-CARE-04-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 6619971.68
EU funding (EUR): 6363250.97
Participants: 23
Project status: SIGNED

SERENA will accelerate efforts to improve access to health and social care (HSC) for child victims of maltreatment (physical, sexual, psychological abuse and neglect) throughout Europe. The major ambition of SERENA is to identify and promote the means of improving the detection of child maltreatment (CM), of limiting its consequences (recurrence, severe conditions), and reducing the induced burden for victims, families, and society. This ambition will be supported by assessments of current care pathways (HSC services), the barriers and inequalities when accessing these services (before and after the recognition of CM, including children's physical and mental health conditions), as well as the financial burden on a societal level. Our assessments will rely on a mixed-method approach combining qualitative analyses in 3 EU countries (interviews with adult survivors of CM (ASCM) and HSC professionals) and quantitative analyses (longitudinal cohort study based on HSC administrative data in 7 countries, but also aggregated CPS data in 26 countries). An interdisciplinary participatory synthesis of the findings (with stakeholders and ASCM) will deliver a co-constructed assessment of the situation and the definition of priority actions. Finally, we will design and promote, through the consortium's extensive network, operationally and economically viable recommendations with potential for transposability across the EU for policy makers and HSC services. The SERENA recommendations will encourage changes in policies in all EU member states so that HSC daily practice can i) be assessed in terms of validity and availability of the services in all areas, ii) identify necessary evolutions to be encouraged through legislative measures (data collection and exchange between HSC services), and iii) provide an awaited shift in CM management. The resulting effects of these changes will include improved detection of CM cases and HSC access, improved management and reduced overall costs.

Keywords: child maltreatment,healthcare,social care,care inequalities,longitudinal cross national analysis,quantitative and qualitative analysis,health economics,mixed method participatory approach