Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bounded Rationality under Uncertainty (BRU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-07-16
End date: 2010-07-15
Duration (months): 24.0
Total project cost (EUR): 157831.18
EU funding (EUR): 157831.18
Participants: 1
Project status: CLOSED

The research project Bounded Rationality under Uncertainty deals with decision theory under uncertainty an is located at the frontier between formal philosophy, theoretical economics and applied logic. The Bayesian orthodoxy in choice under uncertainty, axiomatized by L. Savage in the fifties, is currently disputed by two very different research strands : the bounded rationality program which stresses the crucial role of cognitive limitations in choice, and the Non-Expected Utility (NEU) models like those based on non-additive probabilities (Schmeidler, 1989) that try to improve behaviorally the Bayesian model. Unfortunately, there is no unification between these two research strands : usually, the boundedly rational choice models deal with choice under certainty and the NEU models abstracts from cognitive limitations in the same way that the Bayesian model does. Our general research objective is to build a bridge between these two strands of research and construct models that take cognitive and informational limitations into account. As bounded rationality manifests itself in numerous ways, one can study it with different methods. Our project will (i) focus on one type of cognitive limitations, imperfect reasoning abilities (failures of logical omniscience) and (ii) favor one general method, the axiomatic method ,that is much used in the NEU field but much less in the bounded rationality tradition. To achieve such a general objective, we will adopt a syntactic and logic-based approach and import from philosophical logic (more precisely from epistemic logic) a modeling technique known under the name of impossible worlds. This technique allows oneself to represent cognitive limitations ; we will use it to devise a boundedly rational choice model under uncertainty and provide of this model an axiomatization in termes of agent’s preferences.

Keywords: social sciences,philosophy,logic,economics,economic theory,microeconomics,behavioral science,cognitive science,psychology,epistemology,philosophy of science
Geometric Aspects of Integrable Nonlinear Systems (GAINS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-10-01
End date: 2010-09-30
Duration (months): 24.0
Total project cost (EUR): 161225.98
EU funding (EUR): 161225.98
Participants: 1
Project status: CLOSED

The issues of the research project are focused on the theory of integrable systems and its relation to the field theories. The first objective is further development of the theory of the integrability preserving dispersive deformations of integrable dispersionless systems. Next is the formulation of the classical R-matrix approach to the Frobenius manifolds. Another objective is the revision of the theory of Whitham hierarchies related to the moduli spaces of Riemann surfaces of all genera. The last research objective is to begin the programme on quantization of Whitham hierarchies of all genera, i.e. construction of dispersionful Whitham hierarchies. In our research we are going in general to apply methods of differential algebraic geometry. If the Marie Curie Intra-European Fellowship will be awarded, the proposed research will take place in the research group Integrable Systems and Mathematical Physics at the Department of Mathematics of the University of Glasgow. Scientists from the host institution are leading scientists in the subjects considered in this project. The scientist in charge of the supervision of the project is Dr. Ian Strachan. Training in the above broad perspectives will give me possibility of improving of my knowledge of the theory of integrable systems and its relations with other branches of mathematical physics like Frobenius manifolds. The experience gained will bring me closer to become a fully professional and independent scientist. All these together will contribute to completion and diversification of my expertise.

Keywords: mathematical physics,differential equations,algebraic geometry
A Systems Biology Approach to Elucidate the Yeast Metabolic Network (MRM-YEAST METABOLISM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-01
End date: 2010-04-30
Duration (months): 24.0
Total project cost (EUR): 178163.71
EU funding (EUR): 178163.71
Participants: 1
Project status: CLOSED

The ultimate goal of systems biology is to generate mathematical models to comprehensively describe the dynamics of a biological system. Among all biochemical and informational systems that operate in cells, metabolism is unique because the composition and topology of the network of metabolic reactions is almost completely known. What is currently poorly understood, is how this system operates, how it is controlled and how it adapts to changing conditions of supply and demand. Most current models of metabolism and of biological processes in general are limited by the incompleteness and the restricted diversity of the data they are based on. In this project I propose to generate, for the first time, quantitative data sets of all metabolic proteins and their regulatory phosphorylation sites in the model organism yeast Saccharomyces cerevisiae, under a defined set of conditions. Such a comprehensive proteomic analysis will be achieved by means of a novel targeted proteomics approach, pioneered in the host group and which I preliminarily developed in the first months of my work. In the context of a well-established collaboration with metabolomics and computational systems biology groups at ETH Zurich, the generated proteomic and phosphoproteomics data on metabolic enzymes will be coupled to quantitative data of the associated mRNA transcripts, metabolites and metabolic fluxes. Integration of these different quantitative data types will be done with a genome-scale mathematical model of the whole yeast metabolism. The data generated will be unprecedented and the research will set us on a path towards the understanding of the control structure of S. cerevisiae metabolism and the identification of key regulation sites that actively control metabolic processes, advancing both the science of systems biology as well as our understanding of a universal biological system.

Keywords: targeted proteomics,mrm,systems biology,yeast,metabolic network
Nonlinear Pricing in Vertically Related Industries (NONLIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 170142.1
EU funding (EUR): 170142.1
Participants: 1
Project status: CLOSED

Instances of nonlinear pricing in vertical industries typically involves discount schemes where higher volume purchases or those that involve a larger selection of the supplier’s products lead to lower prices. Some of these discount schemes can generate incentive effects that are often associated with exclusive dealing. In absence of efficiency rationale these are often seen as potential mechanisms to exclude competitors and therefore carry a negative connotation in competition law. Disentangling the underlying motivations for loyalty discount schemes is essential for the capability of competition policy enforcement to separate anticompetitive instances from benign ones. This project aims to generate output that serves this end. Its benefits are likely to diffuse into competition law and policymaking. The applicant has received her PhD at Universitat Autonoma de Barcelona, and holds an assistant professorship at the University of Alicante. She conducts research on industrial economics, and is a dynamic researcher with numerous achievements. To accomplish the project the applicant would spend two academic years in the Economics Department at University College London, a research department in economics. UCL has vast scientific expertise and facilities required for conducting top quality academic research. In addition, its active involvement in interdisciplinary collaborations is valuable for this project. The proposal would contribute to applicant’s academic career. It would help improve her analytical skills and research training, diversify her knowledge, deepen her project management skills, create opportunities for long-lasting collaborations and get in touch with timely antitrust issues. Through the accomplishment of this project, the applicant aims to build a sound publication record, to make relevant research contributions, to advance knowledge, and to achieve professional independence.

Keywords: industrial economics,microeconomics,economic theory
Determination of molecular dynamics in membrane proteins and protein fibrils using novel solid-state NMR methods (DYNAMIC PROTEINS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 159828.87
EU funding (EUR): 159828.87
Participants: 1
Project status: CLOSED

Structural data obtained from X-ray crystallography as well as from NMR spectroscopy has clearly provided evidences that many proteins have intrinsic disorder either locally or globally. Emerging evidence suggests that these small or large-scale deformations occur at various time scales and provide important hints for the regulatory mechanisms of the proteins. In this view protein plasticity is becoming an important parameter for molecular organization and recognition. In this project, we aim to probe the molecular dynamics of membrane proteins and protein fibrils at residue level and atomic detail using novel solid-state NMR methods. Using a combination of NMR pulse schemes that probe relaxation and anisotropic interactions in a residue-specific level, our goal is to understand the molecular level assemblies of fibril proteins and various intermediate states of the fibrilization process. The same methods will be used to elucidate the protein plasticity when embedded in lipid bilayers, providing novel possibilities to probe signaling and cellular uptakes in a functional state.

Keywords: structural biology,solid-state nmr,protein fibrils,membrane proteins,protein dynamics
Impact of the ionic channel and NOS1AP SNPs on the risk of cardiac events in Long QT Syndrome (RISK FACTORS FOR SCD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2009-04-13
End date: 2011-04-12
Duration (months): 24.0
Total project cost (EUR): 164777.73
EU funding (EUR): 164777.73
Participants: 1
Project status: CLOSED

Cardiovascular disease is a leading cause of death worldwide. A number of these deaths are due to severe disturbances in cardiac rhythm (ventricular tachycardia or fibrillation) that lead to a fatal cardiac arrhythmia or sudden cardiac death. Ventricular tachycardia or fibrillation can occur during exercise or excitement, and has been associated with an underlying disorder called Long QT Syndrome (LQTS). The clinical course of LQTS is variable, some patients remain asymptomatic while others develop ventricular tachycardia or fibrillation, resulting in sudden death. LQTS is characterised by an abnormally long heart-beat length (QT interval) by ECG. The QT interval corrected for heart rate (QTc) is variable in the general population and has been shown to be highly predictive of a person’s risk of ventricular tachycardia or fibrillation and sudden cardiac death. ~75% of all LQTS cases have mutations in genes regulating QTc. However, there is large variation in the penetrance of these mutations on QTc, even within single affected families. Recent studies have shown that common genetic variants (SNPs) in genes coding for ionic channels, or neuronal nitric oxide synthase 1 regulator, NOS1AP, can affect QTc in the normal healthy population. Therefore SNPs within LQTS loci may modulate the effect of known mutations in LQTS patients. We will study SNPs in a large cohort of LQTS families with known mutations and predict that SNPs which prolong QTc are associated with a higher risk of cardiac events in the probands compared to asymptomatic LQTS patients. We will confirm the link between QTc and cardiac events in a large population, and that genotype is a determining factor for the age of occurrence of the first cardiac event. This research will help to explain the partial penetrance and high variability of QTc and risk of sudden death in LQTS families, and will have important implications for the early identification and prevention of arrhythmias and sudden cardiac death.

Keywords: cardiology,medical genetics,molecular biology,molecular genetics,cell biology
Reactive oxygen species production and reactive oxygen species mediated signalling (ROS SIGNAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 162509.69
EU funding (EUR): 162509.69
Participants: 1
Project status: CLOSED

Oxygen plays the important role not only in respiration of the organisms. The interaction of oxygen molecules with cell components produces the reactive oxygen species (ROS). ROS is always present in biological cells and their concentration is maintained in continuous level under normal conditions. But the level of ROS increases significantly under stress conditions which may leads to the cells death. However besides the destructive processes in biological structures ROS do execute the role of signal molecules, providing a co-ordination of intercellular processes as well as the adequate response of organism to a disease and environment changes. Hydrogen peroxide is the stable mobile ROS was recognised as most important signal-transducing molecule. The photosynthetic electron transport chain of chloroplast thylakoids is one of the main sources of ROS production in plants but the detailed mechanism of the process remains unknown. Thereby the understanding how these ROS serve as signal molecules and which step of this signal is limit for cells live may help to save the plants from premature death. The main aim of the proposed work is to study how ROS are produced in plants and to understand how these ROS function as the signalling molecules in plants. The site and the molecular mechanism of singlet oxygen, superoxide and hydrogen peroxide formation in the photosynthetic electron transport chain will be investigated in vitro and in plants in vivo. Also the amount of ROS and ROS localization in vivo and the ROS signaling pathways will be investigated in the proposed work.

Keywords: reactive oxygen species,plants,photosynthetic electron transport chain,redox-signalling
Retrieval of global surface mass variations from space measurements (GRAVIMASS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-10-01
End date: 2011-09-30
Duration (months): 36.0
Total project cost (EUR): 230963.71
EU funding (EUR): 230963.71
Participants: 1
Project status: CLOSED

The circulation of geophysical fluids (atmosphere, oceans, continental hydrology) at the Earth’s surface induces global mass redistribution, and therefore gravity changes, as well as global deformations. Since its launch in April 2002, the GRACE (Gravity Recovery And Climate Experiment) mission is measuring time-variable Earth’s gravity field, with spatial and temporal resolutions of a few hundreds of kilometres and 10 to 30 days, respectively, and allows the recovery of global mass variations within the entire climate system. The ESA mission GOCE (Gravity field and steady-state Ocean Circulation Experiment), to be launched at the end of 2007, will improve the knowledge of the smaller wavelengths of the Earth’s gravity field. Thanks to several decades of radar altimetry, elevations changes of the oceans and ice-sheets are mapped with a high precision (at the cm level) and a high sampling rate (from 10 days with Jason-1 to 35-days for ENVISAT). However these missions only allow the retrieval of volume changes rather than mass. For example, sea level variations are not only due to fresh water inputs (from ice-sheet or glacier melting) but also to thermal expansion (steric effects). Continental water storage (soil moisture, groundwater, snow, etc.) cannot be completely mapped from space, as only the top soil layer (few centimetres) can be deduced from radiometer measurements. The analysis of time-variable gravity field (in addition to other remote sensing techniques) will allow closing the mass balance of the climatic system, both on a global scale and regional scales (river or oceanic basins). This project involves the collaboration between two well recognized institutions, with complementary expertises, the Institut de Physique du Globe, hosted at the University Louis Pasteur of Strasbourg in France, and the NASA Goddard Space Flight Center in the USA.

Keywords: earth science,geodesy,geophysics,hydrology,water system modelling
Genetic regulation of protein trafficking pathways: the transport of storage proteins in Arabidopsis (TRAFFIC CONTROL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-12-01
End date: 2010-08-31
Duration (months): 21.0
Total project cost (EUR): 151369.07
EU funding (EUR): 151369.07
Participants: 1
Project status: CLOSED

Trafficking pathways in eukaryotes, their regulatory mechanisms as well as the molecular machinery involved are relatively well understood. However, the underlying genetic regulation has been largely overlooked. The question how cells adapt to various trafficking requirements, and to which extent this regulation is transcriptionally controlled, is of great importance to the field of cell biology and development. In this project, I want to address this question using Arabidopsis seed storage protein trafficking. Late in embryogenesis, large quantities of storage proteins are transported into a novel type of organelle, the storage vacuole. This process is most likely transcriptionally regulated, as it occurs only during this stage of development. Recently, genes involved in this event have been identified in the host laboratory and other groups. I aim to identify the transcriptional regulation of these in order to decipher common cis-regulatory elements, their transcription factors and/or epigenetic regulators. The identified regulators will be first analyzed for functional significance in storage vacuole trafficking. Further analyses will shed light on the fundamental question whether all these responses are developmentally programmed, or whether cells can actually sense their current transport requirements. The proposal is, to my knowledge, the first specifically aimed at the interface between transcriptional control and a cell biological phenomenon. Thus, the proposed project will not only be of interest to plant storage protein trafficking, but also lead to a better understanding of the genetic regulation of plant protein trafficking in general and even other eukaryotic systems, exploring potentially conserved mechanisms. Eventually, identifying the main regulators of storage protein trafficking may also enable altering the storage capacity in vegetative tissues, a trait much sought after in applied plant research to utilize crop plants as biofactories.

Keywords: plant cell biology,transcriptional control,vesicle trafficking,storage proteins,vacuolar transport,plant embryogenesis
The Space of Crisis: Towards a Critical Geography of Complex Humanitarian Emergencies (THE SPACE OF CRISIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2009-12-22
End date: 2012-12-21
Duration (months): 36.0
Total project cost (EUR): 221830.31
EU funding (EUR): 221830.31
Participants: 1
Project status: CLOSED

This research project seeks to develop a radical geographical critique of contemporary humanitarian emergencies within the context of contemporary globalisation. It seeks to do so via an explicitly theoretical approach that is rooted in historical geographical materialism and critical theory, and in theories of the production of space in particular. The project’s principal objective is to elaborate a theoretical platform for the analysis of these crises as explicitly geographical phenomena, in which particular configurations of socio-spatial and political-ecological relations that stretch form the global to the local and back again, are reconfigured through violent processes of contest and struggle to produce particular spatial, social and material configurations of people, institutions and things in particular places to produce ‘The Space of Crisis’. The space of crisis, it will be argued, represents a particular configuration of space and power that is characterised both by the suffering body-subject of the humanitarian victim-beneficiary, and by a particular set of political ecological and socio-spatial conditions that exhibit stunning similarities wherever they are found. These spaces and subjects, occupy a significant position within the overall logic of neoliberal globalisation in that they act as materializations of particular forms of power struggle in place, and occupy the nexus between the conflicting logics of violence and protection which lies at the heart of neoliberal governmentality. This project will examine the particularity of these spaces and subjects through a detailed analysis of the complex relations that produce them.

Keywords: social sciences,humanitarian,space,geography,uganda,sudan,sri lanka,theory,neoliberalism,globalization,capital,sovereignty,biopower