Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rapid, cost-effective, multiplex point of care diagnostic immunoassay system (MultiDiag)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our overall project is to develop and prepare to commercialise a rapid, cost-effective platform for near-patient diagnosis using multiplex immunoassays. Development of a cost-effective system for diagnosis by multiplex biomarker analysis at the point-of-care is essential to enable the delivery of modern, stream-lined healthcare systems in the EU and globally that rapidly and accurately assesses patient needs at the earliest opportunity. Immunoassays are a mainstay of clinical diagnoses. ELISA tests provide sensitive, accurate and quantitative diagnostic data for a large number of disease biomarkers. The technology has not changed for decades and requires central laboratory facilities. Each test measures only one biomarker and takes up to 2 hours to perform. NALIA Systems’ technology provides multiplexed ELISA tests in which panels of 10-15 biomarkers can be tested in parallel, whilst retaining the sensitivity, accuracy and quantification benefits of standard ELISA tests. The first NALIA Arrays are now being made available for use in laboratories. Standard ELISA technology cannot be adapted for use at point-of-care due to the time to result and the complex liquid handling needed. In contrast, the inherent characteristics of NALIA’s array technology mean that it can be incorporated into disposable cartridges and dramatically reduce the time to result. This project will develop a bench-top device and disposable cartridge system for biomarker arrays for diagnosis at the point of care. Initial arrays will be for autoimmune disorders, allergy and infectious diseases, followed by oncology and other diseases. In Phase 1 we intend to confirm the feasibility of achieving a result in <20min; to prepare a product development plan that will lead to a manufacturable device and series of cartridges; to complete a business plan covering all aspects of the commercial opportunity, pricing, market size, competition and route to market; and submit an application for Phase 2 funding.

Keywords: elisa early diagnosis allergy autoimmunity infectious disease oncology multiplex immunoassay
Galactic cosmic RAy Propagation: an Extensive Study (GRAPES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Where do Cosmic Rays (CRs) originate? How do CRs interact with the environment during their journey to Earth? GRAPES aims at revealing the origin of galactic CRs, 100 years after their discovery, by achieving the most accurate description of CR propagation in the interstellar medium (ISM). More specifically: 1) What is the mechanism of propagation in the Galaxy? Measurements show fine structures in the observed CR spectra, but we have exceedingly simplified transport models. In view of the challenges that recent observations posed to conventional homogeneous CR diffusion models, we will develop the first self-consistent simulation of interstellar CR propagation, including non-linear processes, anisotropic diffusion and galactic winds. 2) Where do CR become extra-galactic? Understanding propagation at the end of the galactic CR spectrum is compelling towards the identification of galactic sources. We will provide an innovative approach able to describe at once the CR spectrum and anisotropy up to the knee energy attacking the pending theoretical and observational challenges. These questions are profound, challenging and appealing and can be efficiently pursued only through a new advance in the complex numerical modeling of galactic CR transport and by establishing a tight collaboration between communities involved in CR physics. We live in exciting years, since for the first time experimental techniques allow (or are going to allow) forefront questions to be tackled with the necessary sensitivity. The enormous discovery potential is further witnessed by the fact that the two most advanced experimental projects categorized by the European Astroparticle priority roadmap are specifically tailored to map the high-energy gamma (CTA) and neutrino (KM3NeT) sky with unprecedented level of detail. It is then the perfect time for a motivated and internationally experienced researcher (ER) to connect theoretical modeling and observations at a high level of physical complexity.
ERA Chair in E-Governance and Digital Public Services (ECePS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Estonia
Call: ERA Chairs (H2020-WIDESPREAD-2018-04, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 2486637.5
EU funding (EUR): 2486637.0
Participants: 1
Project status: SIGNED

The aim of the ECePS project – the ERA Chair in E-Governance and Digital Public Services is to strengthen the Center of IT Impact Studies (CITIS), a research unit within the Skytte Institute of Political Studies at the University of Tartu (UTARTU) so that it can act as a world leader in the field of research on e-governance, public e-services and data driven public innovation. We will do so by recruiting a leading expert in the field to serve as an ERA Chair for E-Governance and Digital Public Services who will in turn create a top-level research team capable of conducting cutting edge research that examines the fundamental questions of scientific and practical importance. The ERA Chair will trigger structural changes within UTARTU to support this effort by: • Initiating changes to CITIS research unit, including creation of a CITIS Supervisory Board, formation of advisory groups with members from industry, government and scientific community, and a Professorship position for the ERA Chair. • Integrating researchers from other departments relevant for e-governance research into the CITIS structure, including the SoBigData Research Infrastructure, the Institute of Social Studies, the School of Economics and the Faculty of Law as well as UTARTU’s High Performance Computing Center. • Building partnerships with governments and leading technology companies to create new models for attracting public and private research funding. The ERA Chair will also act as a role model to produce spill-over benefits for UTARTU to modernize rules and practices regarding the recruitment and performance measurement of researchers and professors, systematically implement processes to address RRI priorities and improve UTARTU’s gender policies and practices.

Keywords: e governance,digital public services,data driven policy innovation,3rd generation e services
Monitoring functional traits by combining multi-scale and multi-temporal remote sensing data to assess biodiversity across Europe (BioScal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Biodiversity is a critical indicator of ecosystem functioning and health. Greater native biodiversity enhances ecosystem function, productivity, resilience, variability of the genetic pool, and a multitude of other ecosystem services. With the technology available now, remote sensing is the only efficient tool to assess biodiversity over regional to global scales because it can provide measurements at appropriate spatial and temporal resolutions. Recent studies have started to explore the potential of remote sensing to estimate biodiversity attributes and patterns in natural and managed ecosystems. Most studies to date have used moderate resolution satellites to investigate species richness with somewhat mixed results. Few studies have had access to image spectroscopy data, which allows greater power in determining the relationships between spectral variability and biodiversity. While it is crucial to measure biodiversity across systems and scales, achieving this goal is challenging. Metrics or indicators are necessary for measuring and monitoring biodiversity at regional to global scales. In this line accurate information on functional traits can provide a baseline for monitoring biodiversity. The main objective of this study will be to assess biodiversity based on functional trait monitoring on a diversity of forest communities along Europe. The proposed study will exploit the high spectral, spatial and temporal resolution data obtained from multiple remote sensing instruments. From a remote sensing point of view, the novelty or this research will be to take advantage of each sensor’s capabilities and extend our analysis in both space and time; and from an ecological point of view the novelty could be to develop a workflow for both downscaling and upscaling biodiversity across multiple forest types along Europe.

Keywords: biodiversity monitoring from space,functional traits,ecosystem functioning,biodiversity change
first RESponder-Centered support toolkit for operating in adverse and infrastrUcture-less EnviRonments (RESCUER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Germany,Germany,Italy,Germany,Spain,Greece,Greece,Greece,Slovakia,Greece,France,France,France,United Kingdom,Portugal
Call: Technologies for first responders (H2020-SU-SEC-2020, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 6984803.75
EU funding (EUR): 6984803.75
Participants: 21
Project status: SIGNED

RESCUER aims to design and develop a First-Responder-centered technology toolkit that will empower the next-generation of First Responders (FR) by enhancing their operational capacity and safety, specifically in adverse conditions, both environmental and infrastructure-wise. Adopting the “HERO” (enHanced nEw eRa first respOnder) concept, RESCUER will deliver a toolkit offering (1) sense augmentation through enhanced sensorial input, (2) precise and infrastructure-less self-positioning, (3) cognitive support and multi-sense AR interfaces, improving their focus and capability to utilise information and (4) robust ad-hoc intra-team communications for both verbal and data exchanges, all delivered over enhanced power and communication autonomy features. Extending the above capabilities, through the concept of a building black box, RESCUER will also introduce the capability of extracting environment information “in situ and infrastructure-wise”, during a disaster. The project will achieve these goals using lightweight, non-obtrusive, and natural interaction with devices and sensors that offer additional information layers augmenting human sensing and operational capabilities, rendering FRs better aware of their surrounding conditions and able to make fast and efficient decisions to remain safe in the line of duty. RESCUER will employ a rigorous process for validating the tools developed, through field tests and three distinct pilots, supervising progression to new technologies and ensuring their adoption by FRs through iterative feedback acquisition and a dedicated provision for reducing cognitive overload. The ultimate goal of RESCUER is to introduce the next generation of FRs, who will be better protected, connected and situationally aware, with enhanced operational capacity and able to efficiently operate in infrastructure-less environments without power and communications network.

Keywords: sense augmentation,cognitive support,infrastructure less support,wearables,smart sensing,adverse conditions
Novel neurophysiological techniques to quantify pain and stratify patients (PAINSTRAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy,United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2022-12-31
Duration (months): 84.0
Total project cost (EUR): 1627825.0
EU funding (EUR): 1181995.86
Participants: 2
Project status: CLOSED

In the last 15 years the advances in understanding the molecular mechanisms of pain have been spectacular. However, despite the >200 genes identified and the dramatic insights on transduction and transmission of nociceptive signals, very little has changed in the diagnosis and treatment of pain, at least in terms of analgesic drugs. Therefore, pain remains a major burden for the society (chronic pain alone costs the EU >€250 bns/yr). The reason is that pain is not a pattern of gene expression, but a state of neuronal activity. Therefore, the translation of mechanistic insights into effective treatments will depend critically on a better understanding of the electrophysiological changes that occur. For this reason, the European Federation of Neurological Society has called for a particular effort to identify reliable laboratory measures of pain, and having an objective biomarker for pain quantification and patient stratification would constitute a major breakthrough in medicine. To date, this need has not been satisfied. The project has two main objectives: (1) Developing neurophysiological biomarkers of pain perception: the main aim being quantification of spontaneous pain for patient management and clinical trials. (2) Developing neurophysiological biomarkers of the susceptibility to develop chronic pain: the main aim being patient stratification, development of prevention strategies, and personalised medicine for pain. We will apply novel analysis techniques to the neurophysiological information obtained using a range of techniques from a large number of healthy volunteers and patients with different types of chronic pain. Importantly, we will longitudinally study patients at high risk of developing chronic pain. We are fully confident that these goals - early diagnosis, identification of high risk patients and facilitating the development of new efficacious treatments through useful clinical trials - will positively impact the well-being of chronic pain patients.

Keywords: personalized medicine,patient stratification,chronic pain,neurophysiology
Epigenetic control of retinoic acid-dependent genes during heart development (EPIGENHEART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

EPIGENHEART proposes a unique and competitive training for heart development research centred on congenital heart diseases (CHD), a leading cause of death in Europe . Defects in the pathways involved in myocardial lineages at the venous pole of the heart are found to be the origin of CHD and atrial arrhythmias. Epigenetic gene regulation has influence in maintenance of cellular identity, differentiation, and is deregulated in many diseases. The involvement of epigenetic dysregulation in CHD is poorly described, much of the mechanistic detail involved in triggering these events in the context of heart development remains unclear. RA signalling is preferentially active in the venous pole region of the embryonic heart. A deregulation of the retinoic acid (RA) has been implicated in venous pole defects in patients. How RA signalling takes part in the genetic and epigenetic network regulating the venous pole lineage decisions needs to be studied in details. With the use of in vitro, ex vivo and in vivo approaches in transgenic and deficient mouse embryos combined with transcriptomic and chromatin profiling, the two interacting research lines of EPIGENHEART fulfils this goal. EPIGENHEART is expected to increase the knowledge on the genetic and epigenetic network regulating the formation of the venous pole, which will contribute to better understand the associated heart diseases. Apart from the impact on human health, the project will contribute to ER´s future career prospects and European scientific excellence and competitiveness.

Keywords: congenital heart disease,heart development,transgenic mice,retinoic acid,venous pole
Heating Appliances Retrofit Planning (HARP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Germany,Italy,Italy,Spain,Italy,Belgium,France,France,France,Portugal,Portugal
Call: The role of consumers in changing the market through informed decision and collective actions (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-05-01
End date: 2022-07-31
Duration (months): 39.0
Total project cost (EUR): 1992608.06
EU funding (EUR): 1992608.06
Participants: 19
Project status: CLOSED

Consumers do not think about heating until their system breaks down. When it does, the replacement is always an urgent process, hindering the possibility to look for the best solutions in the market and making smarter choices regarding a heating system that will likely be in operation for the next 20 years. In Europe, there are more than 300 million heaters (space, water or combi) that have, on average, been installed more than 20 years ago. Considering the heating energy label framework, market assumptions are that more than 50% of these equipments perform as C or lower. Old and inefficient, this is the status of the installed heating stock. Now is the time to act and raise consumers’ awareness about the opportunities of a planned replacement. Taking advantage of the energy label for space and water heating, we can mainstream the labelling concept to the installed heating stock, allowing to use a well-known support decision tool to communicate and motivate the consumer to replace its heating system with modern high-efficiency and renewable solutions. HARP accompanies the consumer decision process, providing an impartial message, based on the energy label and presenting the market solutions that respond to the consumer’s heating needs, providing a quantified approach for economic and non-economic benefits and bridging the gap with the market providers and available national incentives. HARP is promoted by key knowledgeable partners in the fields of consumer behaviour, energy efficiency, heating solutions and business models, working directly with the consumer, or indirectly via professionals who are critical multiplying agents. Promoting dynamic efficient heating communities, where all the agents, from the supply to the demand side are committed to an efficient heating market, supporting the consumer to make smarter choices. This allows HARP to build a solid concept that will succeed in the participating countries and within the EU reach.

Keywords: space and water heating,energy label,consumer journey,renewables,energy efficiency
Oceanic Carbon Cycling Response to Global Temperature Changes (CYCLOCARB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2023-05-01
Duration (months): 36.0
Total project cost (EUR): 277061.76
EU funding (EUR): 277061.76
Participants: 1
Project status: CLOSED

Human-caused emissions of carbon dioxide are disrupting the natural variations of the carbon cycle. Past climatic variations provide essential information on the carbon cycling and its associated climate changes to explore different scenarios from unrestrained to even decreased emissions of CO2. In the CYCLOCARB project, we will develop a semi empirical model of carbon cycling and climates over the last glacial cycle, a unique dampened natural analogue for expected anthropogenic forcing’s. This semi-empirical model will be constrained by an extensive database including indicators for temperature and ice volume (δ18O of foraminifers, sea surface temperature proxies) and proxies for global carbon cycling and partitioning between ocean, atmosphere and solid earth (δ13C of foraminifers, carbonate, organic carbon content in marine sediment). Temperature proxies’ records will help refining climatic sensitivity to greenhouse gases, and the temporal evolution of temperature pattern will shed light on the response of the oceans to climate forcing’s. The δ13C of the climatic system will be reconstructed and the effect of the biological pump quantified for the last 150ka, encompassing both a major emission event at termination II and some decreased CO2 intervals. Altogether, our climatic reconstructions and the semi-empirical model will improve our understanding of the natural response of the carbon cycling to anthropic changes. Moreover, CYCLOCARB will permit the quantification of carbon stocks in Exclusive Economic Zones, which could affect Europe national greenhouse gases inventories and marine carbon stock management.

Keywords: paleoclimatology,paleoceanography,paleoecology,sedimentology,palaeontology,biogeochemistry,biogeochemical cycles,geochemistry,isotope geochemistry,limatology,climate change,oceanography,marine science