Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Blockchain-based Middleware Platform for Food Tracking Ledger Builder (FOrLedger)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-04-01
End date: 2019-07-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FOrLedger, an innovative low-code development platform that allows software companies oriented to agrifood supply chain businesses to develop blockchain-based software quickly with minimal coding, minimizing the need for extensive coding experience. These applications support growers in the traceability and in the certification of food products by using the Blockchain technology and Smart Contracts. It helps them build transparency beyond the “one step down, one step up” traceability principle. Furthermore, it improves the integrity of product data and drives efficiencies for stakeholders. The novelty of FOrLedger lies in blockchain technology togetherwith model-driven techniques which is provided “as-a-service” facilitating its integration in any software application within supply chain environment. The blockchain technology allows to make safe and automatic all the transactions along the supply chain, increasing the high-quality production (in particular organic products), improving the environmental sustainability and guaranteeing transparency and safety to the final consumer. The blockchain was developed as a decentralised ledger which records transactions and stores this information on a global network in a manner which prevents it being changed at a future point. While initially adopted for its financial implications, the blockchains’ decentralised system has huge potential for the traceability of supply chains. The blockchain provides a neutral open platform, there is no third party needed to authorise transactions, but rather a set of rules all participants, both users and the operators of the system, must abide by. Blockchain technology is used as a form of proof: proof of existence, proof of ownership, proof of transaction, proof of exchange and proof of value. The blockchain has the potential to take the power of information from Big Food and place it into the hands of the direct customer.

Keywords: supply chain,agrifood,blockchain
Ancient Drivers of Adaptations in Plant Traits (ADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-09-03
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The world has recently seen the worst wildfires in human living memory, including the ongoing siege of California wildfires and 2019-2020 Australian bushfires, which burnt 72,000 square miles. Predictions that global warming will enhance the number of high fire risk days in fire-prone regions highlights the importance of understanding the relationship between plants, climate and fire. Plants that live in fire-prone regions often possess distinctive traits that allow them to thrive following wildfires. However, it remains a major ecological debate if such trait acquisition has actually been driven by fire itself. To understand the drivers of trait acquisition and their continued function in modern ecosystems, we have to look to the past. ADAPT will examine the evolution of the earliest proposed fire-adapted trait, branch shedding in conifers, which emerged in the Permian (280 Mya). To date no research has established the conditions surrounding the origin of this important trait. Therefore, whether this trait emerged as a response to fire or the otherwise changing climate is unknown. ADAPT will test the hypothesis that fire-proneness is a prerequisite for the evolution of fire-adaptive traits, where it will uniquely examine whether a shift in fire-regime post-dates the appearance of branch shedding, suggesting that the trait was the result of multi-agent selection co-opted to improve fitness of some conifers; or prior to the evolution of branch shedding, suggesting that the trait evolved in response to selection by fire and that fire has been a selective force over 100s of millions of years of Earth history. Fire-adapted traits are what continue to ensure survival of plants in Earth’s fire-prone ecosystems. As such, the results of ADAPT are critical if we are to understand the continued functioning of fire-adaptive traits in the changing environmental conditions of the modern world and assess the resilience of Earth’s ecosystems to climate-driven changes in wildfires.

Keywords: paleobotany,late paleozoic,fire ecology,conifer evolution,plant innovation,wildfire,euramerica
Visualisation of translation initiation reaction on single mRNA molecules in vivo (smTI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Translation initiation is a key step in the regulation of protein synthesis and is regulated by at least 12 different initiation factors in eukaryotes (eIFs). However, the underlying dynamics of this process remain unclear. I propose to develop a single-molecule live-cell imaging method that can be broadly applied to study the dynamics of translation initiation on individual mRNAs in human cells. The aim of the project is to visualise the binding and release of eIFs and ribosomal subunits on single mRNA molecules in real-time during translation initiation. This method, combined with imaging the synthesis of a nascent polypeptide on a single mRNA, will address the role of dynamic eIFs assembly in heterogeneous mRNA translation events, such as translational bursting and start site selection. The project will uncover the real-time dynamics of translation initiation, reveal the key mechanism of translation regulation, and provide a powerful and generally applicable method to study translation initiation and other RNA-binding protein interactions with mRNAs. The project will be developed with a leading research group for translation imaging. I introduce single-molecule imaging techniques that would facilitate new research in the group and enable transfer of ideas. The project will expand my research experience, skills, and professional networks, thereby enhancing my career development as an independent researcher.

Keywords: mrna translation,single molecule
Between Social Values and Profitable Performance: The Case of B-Corporations (BCorp)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

How entrepreneurs could profit from social responsible investments? This issue implies a balance between entrepreneurs’ investments in profitable business models and their engagement in non-profit social actions. To address this question, the project studies the B-Corporations as a new legal business form of corporations (private and public) pursuing benefits for society and shareholders. A non-profit certifying organization, B-Lab, analyses the impact of these companies on society, with particular attention to their ability to provide to ‘communities’ beneficial products or services. Although first established in US, now they are present in 34 countries across 121 industries. Employing this legal form of social companies, the proposal exploits the notion of community-focused strategies (CFS) to refer to the actions that entrepreneurs should pursue to establish links with communities to fulfill reciprocal social values. If people join communities to satisfy their identity needs, entrepreneurs might seek to align their ventures’ strategy to them to improve entrepreneurial performance. Building on social identity theory, entrepreneurial and strategy research, this project adopt mainly a demand-oriented approach. First, it tries to explain differences in new ventures’ performance investigating how B-Corps interact with their communities and through them access customers’ information and gaining loyalty. Second, it explores and profiles the B-Corps as new examples of social entrepreneurial ventures. Finally, it studies entrepreneurs’ strategies to develop long-term interactions with the communities. The statistical evidence is drawn from secondary data, surveys to entrepreneurs, and lab experiments. Implications on ventures’ success rate, growth and drawbacks of the interplay between social entrepreneurship and CFS are discussed.

Keywords: social entrepreneurship,communities of social values,social oriented actions,entrepreneurial performance
Power of Algorithms in Discrete Optimisation (PowAlgDO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1437367.0
EU funding (EUR): 1437367.0
Participants: 1
Project status: CLOSED

Convex relaxations, such as linear and semidefinite programming, constitute one of the most powerful techniques for designing efficient algorithms, and have been studied in theoretical computer science, operational research, and applied mathematics. We seek to establish the power convex relaxations through the lens of, and with the extensions of methods designed for, Constraint Satisfaction Problems (CSPs). Our goal is twofold. First, to provide precise characterisations of the applicability of convex relaxations such as which problems can be solved by linear programming relaxations. Secondly, to derive computational complexity consequences such as for which classes of problems the considered algorithms are optimal in that they solve optimally everything that can be solved in polynomial time. For optimisation problems, we aim to characterise the limits of linear and semidefinite programming relaxations for exact, approximate, and robust solvability. For decision problems, we aim to characterise the limits of local consistency methods, one of the fundamental techniques in artificial intelligence, which strongly relates to linear programming relaxations. Recent years have seen some remarkable progress on characterising the power of algorithms for a very important type of problems known as non-uniform constraint satisfaction problems and their optimisation variants. The ultimate goal of this project is to develop new techniques and establish novel results on the limits of convex relaxations and local consistency methods in a general setting going beyond the realm of non-uniform CSPs.

Keywords: discrete optimisation,linear programming,convex relaxations,constraint satisfaction problems
Sloshing Wing Dynamics (SLOWD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Italy,South Africa,Germany,Belgium,United Kingdom,United Kingdom,United Kingdom
Call: Multidisciplinary and collaborative aircraft design tools and processes (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-09-01
End date: 2023-08-31
Duration (months): 48.0
Total project cost (EUR): 3156751.25
EU funding (EUR): 3156751.25
Participants: 10
Project status: SIGNED

SLOshing Wing Dynamics (SLOWD) aims to investigate the effect of sloshing on the dynamics of flexible, wing-like structures carrying a liquid (fuel), through the development of experimental, numerical and analytical methods, and to use sloshing to reduce the loads occurring from gusts and turbulence. Its main goal is to provide a holistic approach (both experimental and numerical) in order to quantify the energy-dissipation effects associated with the liquid movement inside the fuel tanks, as the wing undergoes dynamic excitations. An increase of the order of 50% in the damping characteristics of the structure is expected.

Keywords: sloshing,wing,dynamics,experimental,numerical
PRE-DISposal management of radioactive waste (PREDIS)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Italy,Germany,Spain,Italy,Italy,Ukraine,Germany,Germany,Bulgaria,Finland,Hungary,Romania,Switzerland,Norway,Belgium,Greece,Hungary,Lithuania,Belgium,Hungary,France,France,France,France,Czechia,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Developing pre-disposal activities identified in the scope of the European Joint Programme in Radioactive Waste Management (NFRP-2019-2020, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 23743742.75
EU funding (EUR): 14000000.0
Participants: 51
Project status: SIGNED

The PREDIS project targets the development and implementation of activities for pre-disposal treatment of radioactive waste streams other than nuclear fuel and high-level radioactive waste. Member States will profit from measurable benefits including the further development and increase in Technological Readiness Level of treatment and conditioning methodologies for wastes for which no adequate or industrially mature solutions are currently available, including metallic material (WP4), liquid organic waste (WP5) and solid organic waste (WP6), and by testing and evaluating innovations in cemented waste handling and pre-disposal storage (WP7). These technical Work Packages align with priorities formulated within the Roadmap Theme 2 of EURAD and with those identified by the project’s industrial End Users Group (EUG), and follow the 50% co-funding principle. Furthermore, PREDIS will produce tools guiding decision-making on the added value of the developed technologies and their impact on the design, safety and economics of waste management and disposal (WP2). PREDIS will also liaise with EURAD to provide complementarity on areas including the adaptation and update of the reference founding documents of the EJP (vision, roadmap, governance and implementation mechanisms) (WP2), and the organisation of training courses and mobility training schemes to enhance sharing and transfer of knowledge and competences as part of knowledge management activities (WP3). The PREDIS consortium, which includes 47 partners from 18 Member States, and EUG, which specifically targets Radioactive Waste Producers (RWP) as a separate group within the radioactive waste management process. PREDIS also encompasses the wider European Community, allowing cross-fertilisation and interaction between different national programmes. Numerous dissemination activities (WP1), including with Nugenia, IAEA and NEA, will be undertaken to maximize PREDIS’s impact to all the identified Stakeholders in the field

Keywords: waste,treatment,pre disposal,safety,radioactive,radionuclides,nuclear,science and technology,monitoring,packages,material science
PERtussIS COrrelates of Protection Europe - Sofia ref.: 115910 (PERISCOPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Spain,Ireland,Germany,Switzerland,Belgium,Finland,Belgium,Switzerland,Belgium,France,France,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Pertussis vaccination research (H2020-JTI-IMI2-2015-03-two-stage, 2015)
Start date: 2016-03-01
End date: 2022-08-31
Duration (months): 78.0
Total project cost (EUR): 29926687.0
EU funding (EUR): 21000000.0
Participants: 27
Project status: SIGNED

Pertussis vaccines have been very successful in reducing the global burden of pertussis-related disease. However, in the last decade there has been a rise in pertussis incidence, particularly in vaccinated adolescents and adults in industrialized countries. The increased circulation of B. pertussis (Bp) constitutes a risk for transmission to vulnerable infants and older adults. Additionally, immunity in humans has been shown to wane rapidly after immunization with pertussis vaccines, especially with acellular pertussis (aP) vaccines, suggesting that the improved reactogenicity profile of aP compared to whole cell pertussis vaccines, may be accompanied by differences in duration of immunity. The key objectives of PERISCOPE are to 1. identify biomarkers of protection against Bp colonization and disease; 2. foster scientific innovation and rebuild the ecosystem and technical infrastructure needed in Europe to allow the future evaluation of novel pertussis vaccine candidates and 3. improve understanding of the pathogenesis of Bp infection and its potential impact on the recently observed changes in pertussis epidemiology. To reach these objectives, PERISCOPE brings together a selected group of internationally recognized public and EFPIA partners with strong expertise in clinical trials, immunology, molecular microbiology, human and animal challenge models and bioinformatics. We will initiate a series of (pre)clinical studies and develop harmonized human and animal challenge models, standardized assays and cutting-edge techniques to unravel the innate and adaptive responses to Bp. This will allow us to identify biomarkers of protection and durable immunity. PERISCOPE will thus facilitate the accelerated development and registration of novel pertussis vaccines and/or guide optimal use of vaccination strategies. The introduction of improved pertussis vaccines will help to reduce the global burden of pertussis.

Keywords: bordetella pertussis,vaccines,biomarker discovery,systems vaccinology,pathogenesis,regulatory
Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases (CaSR Biomedicine)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Italy,Spain,Austria,Italy,Switzerland,Hungary,Hungary,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 3657194.64
EU funding (EUR): 3657194.64
Participants: 18
Project status: CLOSED

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2+ ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling. The objectives of CaSR Biomedicine are: 1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective. 2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general; 3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders. 4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area. Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).

Keywords: calcium,g protein coupled receptor,signalling bias,calcimimetics,calcilytics,pathophysiology