Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
De novo design of an UpConverting metalloProtein (UCLnProt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Herein, we propose to design de novo (“from scratch”) the first upconverting metalloprotein. This will be achieved by exploiting a new class of lanthanide coiled coils (LCC), to generate bimetallic derivatives. These will, for the first time, combine the attractive photophysical properties of Ln complexes, with de novo designed coiled coil scaffolds capable of selectively binding different Ln ions at well-defined and tuneable distances. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology, such as upconversion. The complementary expertise of Dr Sinha (bioinorganic synthesis and computational modeling) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full potential of multimetallic LCCs, and will, in conjunction with two planned short secondments, provide Dr Sinha with new and cutting-edge research training.

Keywords: bioinorganic chemistry,peptide design,lanthanides,upconversion
New Super Resolution microscopy solution for living cell imaging (LiveCODIM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France,Czechia
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-07-01
End date: 2021-09-30
Duration (months): 39.0
Total project cost (EUR): 3601250.0
EU funding (EUR): 2499999.0
Participants: 2
Project status: CLOSED

In the last years, major advances in imaging have significantly contributed to the improvement of EU citizens’ quality of life, from research to diagnostic and therapy. Super Resolution microscopy (SR) is a milestone discovery which goes beyond the limits of optics, typically around 250nm, or ¼ of a μm (one can see inside a virus!). Nevertheless, SR has yet to become a standard imaging modality, like the confocal or the widefield microscopes. Dissemination is still slowed by three critical challenges - damage to the biological tissue – it’s almost impossible to observe live cells - technical complexity – only highly skilled operators can use the instruments - cost of ownership – typically around half million euros for a complete solution BioAxial, a Paris-based company, has developed the CODIM family of SR microscopes, using proprietary and well-patented technology. After proof of concept, a 1st generation system has been acquired and is used by major players (Pasteur Institute, Sanofi, Konica Minolta). Leveraging our core technology, LiveCODIM changes the game, scaling up SR microscopy, with a breakthrough solution: - specifically designed for the study of living cells - a plug and play system requiring neither extensive, multi-skill staff training nor complex sample preparation - 3x more cost-effective than the few other comparable solutions, with higher resolution - which turns any fluorescence microscope into the latest generation SR system. Not just an evolution, but a genuine revolution, LiveCODIM initially addresses the life science imaging market, a 1Bn€ playground, and has many other potential applications, in diagnostic (human tissue) and outside life science. This project brings multiple benefits to EU citizens, by its contribution to life and environmental improvement.

Keywords: fluorescence imaging,single cell imaging,particle tracking,living cell imaging,super resolution,microscopy,biomedical engineering,image processing,tissue diagnostic,neurology,cancer
Enhance driver behaviour and Public Acceptance of Connected and Autonomous vehicLes (PAsCAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Estonia,Belgium,France,France,France,United Kingdom,United Kingdom,United Kingdom,Luxembourg
Call: Driver behaviour and acceptance of connected, cooperative and automated transport (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 3974041.25
EU funding (EUR): 3974041.25
Participants: 15
Project status: CLOSED

The 36-month PAsCAL project proposes an awareness-driven and large-scale penetration approach to address all issues raised by the majority (if not all) of the general public that hinder the wide market uptake of Connected and Autonomous Vehicles (CAV). It will not only focus on the interaction of the “users” in or near CAV, but also assess the impact of connected transport on people’s well-being, quality of life, and equity. PAsCAL will use of a strongly interdisciplinary mix of innovative tools from both human science and technology, to capture the public’s acceptance and attitude, analyse and assess their concerns, model and simulate realistic scenarios for hand-on practices, and validate the research innovation in a number of trials in the real world. The association to the consortium of special categories of users, such as disabled persons, and of service providers with a global outreach of millions of members and several thousand customers across the EU will ensure results consistency, taking into account major social obstacles/barriers that may hinder the acceptance of CAV and would allow their reuse in new businesses, services and applications.
Innovative Future-Proof Testing Methods for Reliable Critical Components in Wind Turbines (INNTERESTING)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Belgium,Finland,Belgium,Finland
Call: Developing the next generation of renewable energy technologies (H2020-LC-SC3-2019-RES-TwoStages, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 4751413.75
EU funding (EUR): 4751413.75
Participants: 8
Project status: SIGNED

The future wind turbines will require flexible and economically affordable PDPs to obtain reliable and validated new concepts for bigger wind turbines or already installed turbines. One of the most critical components that have a high contribution to wind farms OpEx costs are the bearings (selected Case Studies 1 and 3 during INNTERESTING) and gearboxes (selected Case Study 2 during INNTERESTING). Since both components transfer high loads and have high failure rates, they are considered as critical components inside the wind turbine. Although the percentage of the total Capex cost of bearings (2% ) is not as high as other structures (e.g. blades 22% and gearbox 13%) , their role is not insignificant.However, the role of bearings and gears in the OpEx is higher due to the major impact of early. The fatigue requirements that must be assured for the lifetime is a key factor to reduce the negative effect of reparations. New wind energy key concepts and uses which are faster to commercialisation have been prioritised: INNTERESTING project aims to accelerate wind energy technology development and increase lifetime extension of wind turbine components by developing a disruptive methodology to demonstrate reliability of larger wind turbine critical components without the need of building larger test-benches in the future by overcoming size dependent issues during design process and testing. In this matter, INNTERESTING project pursues the development of innovative virtual and hybrid testing methods for prototype validation of pitch bearing and gearboxes components (Selected Study Cases Components). The new methodology will help saving time and money during the product development process (PDP) by integrating virtual testing and hybrid testing: including innovative non-physical and scaled/simplified physical testing. In comparison with current methodologies INNTERESTING will reduce considerable environmental and economic impacts, and improve social acceptance.

Keywords: wind turbines,pitch bearing,gearboxes,lifetime extension,virtual and hybrid testing
Feasibility study for the further development and market launch of the Archimedes Universal Decision Support System for irrigated crops growers (ARCHIMEDES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Bulgaria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the language of irrigated agriculture, the word ‘water’ means ‘problem’, and that problem is often a crucial one. This argument may sound pathetic but it is not at all exaggerated, particularly given the range of challenges, both economic and environmental, faced by the farmers engaged in this domain. So the need for universally applicable measures addressing the water misuse problem in agriculture is here and, obviously, the world has already realized it: various attempts are made to find a solution in different parts of the globe, including in Europe. The fact is, however, that the problem persists, and this is largely due to the lack of a verified scientific approach to ensure its effective yet inexpensive solution. Thus far. With this Project Proposal the applicant Archimedes UDSS LLC presents the scientific basis, already tested and proven on-field, together with the business concept for transforming it into a user-friendly decision support system (DSS) for irrigated crops growers. Practically, our prospective product is designed to answer all the key questions left open by the present alternatives, through: - A universal approach to the problem applicable to any crop, anywhere on Earth; - A solution underlying a complex of verified biophysical equations in line with the laws of nature, eliminating the need for additional measuring equipment on-field; - A DSS allowing precise scheduling the yield amounts by crops yet at the start of the growing season; - And last but not least, a green technology sparing both the freshwater as a resource and the nature as a whole. All this potential turns the future Archimedes product into an innovation able to disrupt the agro-consulting solutions market and change the very way irrigated farming is done. So we are up to shape the brighter future of agriculture – and will be happy to have the EU by our side in the struggle with the harmful environmental effects of farming on a global scale.

Keywords: farming,irrigation,decision support system dss,crop yields planning
Researchers for European Green Growth And Education (REGGAE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal,Portugal
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-05-01
End date: 2021-11-30
Duration (months): 7.0
Total project cost (EUR): 153881.25
EU funding (EUR): 153881.25
Participants: 3
Project status: CLOSED

REGGAE will showcase the role of scientists in the achievement of a greener, more resilient and innovative European society, by involving researchers and public side by side in lively activities. By engaging adult citizens and showing how innovation and knowledge can lead to growth and to a more sustainable future, the project will also contribute to reinforce trust in science and its methods. Young researchers, as role models for students, will be involved in activities specifically designed for youngsters and schools, in order to promote STEM careers. The topics addressed in the activity programme will cover the main areas of the European Green Deal, namely, climate ambition; clean energy; circular economy; energy and resource efficient buildings; sustainable and smart mobility; farm to fork; biodiversity and ecosystems; zero-pollution and toxic free environments. The programme of ERN and warm-up events will include lively formats like hands-on activities, workshops, science shows, science cafés, demonstrations, informal talks with researchers and guided tours, specifically designed according to the age-group and social background of the participants. The detailed programme will be developed by a consortium that includes research centres - IBMC and ITQB - and science communication institutions closely connected to universities (science centres of the Ciência Viva National Network). All the participating institutions have a large experience in organizing both face-to-face and online engagement activities, enabling to ensure an extensive impact of the project even if health contingencies still apply. Both the research centres and the Ciência Viva network provide extensive dissemination channels that will ensure the engagement of a wide range of stakeholders and publics.

Keywords: researchers,citizens,public engagement,interaction,non formal education,green growth
Solution-phase lighting-emitting devices for optogenetic control of the peripheral nervous system (solLED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Delivering light deep into tissue is an important open challenge in biomedical engineering, with particular relevance for optogenetics. One feasible solution is the application of miniaturized bio-implantable light-emitting devices. Such devices should be able to adapt to stimulate cells in tissues with different shapes, sizes, stiffness, and mechanical characteristics. OLED is the most successful light application in current display technologies with many advantages but it cannot adapt to the extreme requirement in three-dimensional structures. The limitations come from the multi-layered device architecture and manufacturing process of vacuum evaporation. Here, we propose a radically different device concept, a solution-phase light-emitting device (sol-LED) with a simple structure that can readily adapt various form factors and thus is of particular relevance to novel applications in the biomedical context. The sol-LED consists of electrodes and a solution that adopts the exciplex host-dye guest system. The fabrication is based on the process under liquid-state such as injection and capillary processes to fill the space in pre-formed devices. The proposed sol-LED will take advantage of existing state-of-the-art OLED materials and established OLED device physics and translate them to the liquid state by dissolving solid-state materials in suitable solvents. Apart from developing this entirely novel type of light source, the use of sol-LEDs as light-source for optogenetics will be developed and tested. Sol-LED with a needle-like shape will be produced by injection of the solution into a hollow microneedle. The resulting devices will be implanted into muscles of the posterior thighs of mice. The motor function will then be mimicked by alternating stimulation of the muscle cells responsible for contraction of the left and right legs. With this, we will test if the device can stimulate cells in vivo with constant intensity and frequency despite strong muscle movements.

Keywords: organic electronics,optoelectronics,bio implantable device,solution phase device,device fabrication,optogenetics,peripheral nervous systems,neuroscience
Computation of cOmpouNd rotorCraft latEral RoTor nOise (CONCERTO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,France
Call: Lateral rotor noise prediction dedicated to low noise footprint optimisation of a compound helicopter (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2021-09-30
Duration (months): 43.0
Total project cost (EUR): 634936.25
EU funding (EUR): 634936.25
Participants: 2
Project status: CLOSED

The main objective of the CONCERTO project is to provide the topic leader (Airbus Helicopters) of the Clean Sky 2 IADP Fast Rotorcraft with a new computational tool enabling the noise modelling and prediction of lateral rotors installed on the future LifeRCraft demonstrator. This tool, enabling both fast prediction and high fidelity approaches, will include 3 modules: aerodynamics, free field acoustic and scattering effects. All three will be, implemented in a chaining process, based on a seamless workflow and software environment that will be created during the project. While aerodynamics module relies on PUMA code (Free Wake) as Fast aerodynamic solver and TAU code (CFD) as High fidelity solver, free field acoustic solver will use the KIM code (FW-H). KIM code will also be implemented for fast scattered acoustic prediction, while BEMUSE code (BEM) will be implemented for high fidelity scattered prediction. The overall tool will be validated and applied to a subset of the LifeRCraft flight domain. The project will be implemented through 6 WPs: WP1 Workflow definition and implementation; WP2 Aerodynamics module; WP3 Free-field acoustic module; WP4 Scattered field acoustic module; WP5 Validation; WP6 Project Management, dissemination and exploitation. CONCERTO consortium, ONERA and DLR, will deliver and install the necessary tools at the topic leader location including documentation, support and possible updates during the 3 years of the project. With a total budget of about € 635,000, the project will go beyond the state of the art (investigating unsteady flight cases, capturing quadripole noise sources, solving efficiently the multi-frequency problem of combined main rotor and lateral rotors, etc.), and will fully address user needs, contribute to the maturation and future commercialization of a new aircraft vehicle satisfying new mobility roles, thus contributing to the competitiveness of the European aeronautics sector.

Keywords: compound helicopter,rotorcraft,acoustic,noise,aerodynamic,rotor,propeller
Neuron-based Monitoring Electrochemical Bio-Sensor Interface System (NeMESIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Reliable, real-time detection systems for in-vivo, continuous monitoring of biological and chemical processes consist a crucial aspect in personalised healthcare. Nevertheless, even nowadays, the medical practice still lacks of systems providing a rapid, reliable and ultra-sensitive sensing in a continuous way. Meanwhile, inflammatory markers consist a pivotal tool in clinical practice since they may be indicators of specific diseases, along with signalising the response of a patient to a specific medical treatment. Nanotechnology-based devices exhibiting memristive electrical properties show great potential for delivering highly scalable, resilient, power efficient and reconfigurable electronic systems. In addition, when those particular nanodevices are subjected to appropriate surface treatments and implemented in the role of bio-inspired sensors, they can bring solutions and introduce novelty to the bio-sensing field regarding highly sensitive and robust detection of biomarkers, while expanding and broadening the research field and applications involving memristive phenomena. In the framework of this fellowship, a flexible, low-cost miniaturised minimally invasive sensing platform will be developed, implementing memristive nanoscale devices as intelligent bio-interfaces, allowing reliable, continuous and real-time monitoring of inflammatory markers. This scheme will be accomplished by the fabrication of a memristor-based sensing platform conjugated with a sensing membrane and an accordingly designed binding assay. Validation of the sensing platform for continuous monitoring will be followed by the integration on flexible substrates for in vivo measurements and integration with readout circuitry enabling the sensing data readout and the wireless transmission to a tablet or smartphone. Finally, the sensing platform will be applied for in-vivo, real-time monitoring, for the detection of inflammatory markers and for indicating the response to an applied treatment.

Keywords: memristors,continuous monitoring,inflammatory markers,nanoscale devices,in vivo bio detection