Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Critical solutions for elderly well-being (RISE-WELL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Slovakia,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-03-01
End date: 2024-04-30
Duration (months): 50.0
Total project cost (EUR): 2691279.36
EU funding (EUR): 2691279.36
Participants: 7
Project status: SIGNED

Mental health and emotional well-being during old age (60+) should be regarded as important as at any other time of a persons’ life. Older people are more likely to experience events that affect emotional well-being, such as bereavement or disability. Unfortunately, mental health problems are under identified in older people, whom themselves are also less likely to seek help as compared to other people in the population. It is estimated that over the next 30 years, the proportion of elderly people (aged 60 or above) is estimated to increase from 12% to 22%. This would mean that there is expected to be 2 billion people of 60+ by 2050 in absolute terms. Older people are confronted with a variety of physical and mental health challenges and unfortunately these are not always, if indeed at all, thoroughly addressed. If we only focus on the mental health issues, then more than 20% of adults aged 60+ suffer from a mental disorder and 6.6% of all disabilities that occur is attributed to those same disorders. The disability caused by mental disorders account for 17.4% of a persons' living years. The assessment of our elderly population, with respect to mental health, therefore requires an understanding of the full spectrum of the mental health continuum, and not to categorise everything into a ‘neurological disease’ or ‘dementia’ category. In particular, we would need to dissect the complex interaction between specific medical conditions, mental stress as part of the ageing process and social circumstances. To be able to offer effective support to tacking this issue, our project aims to carry out three important objectives: a) to implement novel scientific and technological innovations, including strengthening of information systems, b) to initiate care strategies for the short-term, including lifestyle interventions and promotions, to improving the quality of life of older people and c) to build a sustainable long-term infrastructure for elderly care.

Keywords: elderly,mental health,sensors,quality of life,well being
DEVELOPMENT OF A SPIRAL LAMINAR FLOW INDUCING ENDOVASCULAR STENT FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE (SpiraStent)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project is focused the medical device sector and specifically peripheral vascular (PV) devices. A large, unmet, and growing patient population will require treatment for Peripheral arterial disease (PAD) and revenue in this market will continue to grow driven by the aging population and the increased incidence of obesity and diabetes. Percutaneous transluminal angioplasty (PTA) is the most widely used non-surgical treatment, however when used in areas of long calcified stenosis, PTA does not show satisfactory results at long term follow up. Stenting has become the most obvious choice to overcome the limitations of PTA. Unfortunately, long term performance of stents appears to be problematic as they do not prevent (and may to a certain extent even cause) a failure mode known as restenosis. Whilst covered stents have tackled the problem of restenosis within the stent the stent itself interrupts the bloods natural spiral laminar flow (SLF) and increases laterally directed forces and wall shear stress downstream of the implantation causing downstream disease progression. Re-institution of the bloods SLF reduces the forces and turbulence caused by stenting, and reduces neointimal hyperplasia (NIH) distal to the stent which can lead to occlusion distal to the stent. The global objective of the project is to develop an innovative endovascular stent that will reintroduce the natural spiral laminar flow both through the stent and distal to the stent that can be manufactured to be deployed using standard delivery system profiles. With the long term post project target of increasing patency rates to greater than 80% and reduce restenosis of the stent by greater than 20% and distal stenosis by greater than 20% at 2 year follow up. As a result of the proposed project, we expect to improve our collective competitiveness and generate increased sales by capturing at least €25M p.a. of the European market for endovascular stents

Keywords: vascular surgery,peripheral arterial disease,stent,re stenosis,blood flow patterns
Identification of insulin signalling factors that delay age-related memory impairment (AGE-MEMORY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Greece
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 164653.2
EU funding (EUR): 164653.2
Participants: 1
Project status: CLOSED

Elucidation of the biological mechanisms that govern ageing can facilitate the discovery of evolutionarily conserved factors, which denominate physiological deterioration in humans. Here we will study the effect of insulin/insulin like growth factor signalling (IIS), shown to delay ageing in several organisms, on age-related memory impairment (AMI). We will use both C. elegans and Drosophila as experimental platforms, to test evolutionarily conservation of findings. Longevity combined with memory experiments will be applied in several IIS mutants. We will dissect IIS to find putative mediators of IIS effects on cognitive function. To identify relative mechanisms we will measure activity of known AMI regulators in IIS mutants. Depending on our results, our study will expand on transcription profiling worms and flies IIS mutants of different ages. Neuronal genes differentially affected by IIS will be further studied. We will use novel imaging techniques to characterize morphological changes that occur through ageing in the nervous system. This study is a first step to identify universal mechanisms that underlay cognitive function decline. Pharmacological manipulation of such mechanisms could delay AMI in humans.
Finite Element Resonant Ultrasound Spectroscopy to Characterize Maturation of Cortical Bone Elastic Properties (FE-RUS-Blast)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 2
Project status: CLOSED

Osteoporosis has become a major public threat with high costs to the health system. As an important issue of research on osteoporosis, tissue elasticity, i.e. the whole set of the anisotropic stiffness constants on millimeter scale, that directly decides the bone resistance and fracture risk, is still poorly assessed by prevailing biomechanical methods. The state-of-art approach to determine bone elasticity is the ultrasonic pulse method by measuring acoustic velocities along various directions of a specimen with a major drawback of sample size limitation, typically larger than 5 mm. However, studies on bone metabolism greatly relies on small animals, e.g. rabbit, rat, and mouse, with cortical thicknesses close or smaller than 1 mm. Resonant ultrasound spectroscopy (RUS) has been well established to measure the anisotropic elasticity of small metallic samples. However, it was known to be not suited to high-damping materials like bone, due to complicated extraction of resonant frequencies from overlapping resonant peaks. We aim to develop a new RUS method for the accurate elasticity determination of small animal bones (femora and tibiae). New strategies of a non-linear optimization and Bayesian formulation of the inverse problem, recently proposed by the host lab, will be used to overcome the material limitation of bone attenuation. Moreover, the novel combination of the finite element (FE) method and RUS will be used to relax the regularly-shaped sample restriction for the practical application. The applicant will perform an extensive methodology development, including theoretical analysis, numerical simulation, signal processing, and inversion scheme. The new technology will be validated by measuring elastic maturation of cortical bone in rabbit model. The originality comes from the multidisciplinary combination of innovative technologies towards the bone elasticity determination in response to current technical deficiency of small animal bone quality evaluation.

Keywords: resonant ultrasound spectroscopy,cortical bone,anisotropic elasticity,maturation
Centre for ExcelleNce in TerRItorial management and Cadastre (CENTRIC)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Italy,Germany,Belgium,Romania,Luxembourg
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 498500.0
EU funding (EUR): 498500.0
Participants: 8
Project status: CLOSED

Unlike most European countries, Romania does not have yet a general cadastre. Such a deficiency represents a critical element for the economy of the country, since it makes legal contracts, such as land purchasing, very difficult to be implemented. Starting from such a complex scenario, CENTRIC aims –in the long term- at the creation in Romania of the new Centre of Excellence on territorial management and cadastre. The future Centre will focus on related domains of great relevance, such as: 3D/4D geospatial data, linked geospatial data, land classification, remotely sensed data, etc. In particular, the goal of phase 1 of the project (the 12 months CSA) is to prepare a very detailed business plan leading, during phase 2, to the establishment of the Centre including: a long-term vision and the mission of the Centre, a detailed SWOT analysis of the domain of territorial management and cadastre in Romania, a long-term scientific and innovation strategy, a market analysis, the Business Concept of the Centre, the analysis of possible cooperation, strategic alliances and long-term partnerships, the operational and financial plan of the Centre, to define a strategic growth roadmap. Furthermore the project will also aim at the creation of a suitable ecosystem at the national Romanian and EU level, through a number of capacity building and dissemination activities. The whole project has been based on the creation of long-lasting (beyond the 5-years duration of the overall “Teaming” project) joint venture between partners from both advanced and low performing countries, including institutional cooperation among the Romanian Cadastre agency and the counterpart in Trentino Italy considered as a best practice at the EU level. The project is aligned with the Romanian Smart Specialisation Strategy and it has received a clear commitment from the Romanian Government to provide financial resources for infrastructural and equipment costs for phase 2.

Keywords: cadastre,territorial management,3d geospatial data,capacity building,research and innovation agenda,strategic growth roadmap
Smart technology for analysis and monitoring of Cultural Heritage materials (SmARTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-07-28
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The recent advances in open-source and low-cost software and hardware are increasing the number of technologies based on the ‘sharing-knowledge’ philosophy, allowing users to develop their own instruments according to their analytical needs. The aim of SmARTS is to develop a device for inspection, monitoring and analysis of Cultural Heritage materials (objects and structure surfaces) by means of multi-analytical approaches based on a low-cost apparatus. The SmARTS device will be tested by monitoring the conservation state of a set of stained glasses from the Sagrada Familia church of Barcelona (Spain), as well as related metal frames. The device will be equipped with multiple sensors to acquire environmental data (temperature, humidity, etc.) as well as analytical data (UV-IR, thermal signals, colorimetric, etc.), and micro-cameras in order to integrate the collected data with real-time imaging. A software for signal processing and data mining completes the design. The innovation lies in the use of low-cost, open-source hardware and software, which allows a sustainable approach to Cultural Heritage preservation. The originality lies in the device’s modular architecture, conceived as a hub controlling different sensors modules which can be easily assembled or disassembled, so ensuring an extremely flexible analytical instrument, adaptable to different materials and contexts. SmARTS is highly committed to EU's strategy endorsed in the field of Cultural Heritage preservation, by promoting an interdisciplinary approach, and by proposing the application of cutting-edge science and technology . Moreover, SmARTS integrates the applicant’s knowledge in conservation science into a top level research team of the University of Vic (Spain), the MECAMAT, whose research focuses in material science and mechatronics with a strong commitment with the private sector. This will enhance the capacities to convert the research results into commercial opportunities.

Keywords: cultural heritage conservation science,material analysis,mechatronics,low cost technology,open source,sustainable cultural heritage
Baltic Biomaterials Centre of Excellence (BBCE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Switzerland,Latvia
Call: Teaming Phase 1 (H2020-WIDESPREAD-04-2017-TeamingPhase1, 2017)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 399573.75
EU funding (EUR): 397623.75
Participants: 6
Project status: CLOSED

The Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre (RBIDC) is a part of Rigas Tehniska Universitate, Latvia (RTU). The RTU RBIDC research team is composed of chemists, chemical engineers and materials scientists. RTU RBIDC scientists are working on well-defined materials science research areas for bone tissue replacement and regeneration. There has been a long lasting cooperation between RTU RBIDC and the Latvijas Organiskas Sintezes Instituts (LIOS) on investigations of biomaterials developed in RTU RBIDC. LIOS has vast experience in preclinical testing of biological/pharmacological activity in in vitro and in vivo systems. Biomaterials developed at RTU RBIDC, in cooperation with clinicians from the Rigas Stradina Universitate, Latvia (RSU) and Riga Stradins University Institute of Stomatology (RSU IS), which starting from 15 June, 2018 has been added to project as a new partner, have been tested in clinical practice in more than 400 patient cases. RTU RBIDC research fields and scientific capacity will be the core for establishing a new Baltic Biomaterials Centre of Excellence (BBCE) and by adding the crucial experience of RSU, RSU IS and LIOS research fields, full-cycle development of biomaterials will be covered. Establishment of Centre of Excellence will provide an opportunity to combine expertise and infrastructure, to create critical mass and excel at specific field and create spill-over effects between different fields. Within the formation of critical mass in research and development, also the cooperation between industry and research organisations will be encouraged, leading to technology transfer and delivery of new products in the market. Hence BBCE project´s main objective is to establish a joint Baltic Biomaterials Centre of Excellence for advanced biomaterials development based on the long-term strategic cooperation between AO--Forschungsinstitut Davos, Switzerland (ARI) and Friedrich-Alexander-Universitaet Erlangen Nuernberg, Germany (FAU) on the one hand and RTU RBIDC, LIOS, RSU IS and RSU on the other hand.

Keywords: excellence centre,business plan,biomaterials,medical devices,roadmap
A quantum network for distributed quantum computation (QUNET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1499910.0
EU funding (EUR): 1499910.0
Participants: 1
Project status: SIGNED

A key question for quantum science is: Can quantum systems be protected from decoherence? This is not just a fundamental question; if we can reliably control large quantum states, it becomes possible to perform precise tests of quantum mechanics and computational tasks that go beyond classical physics. A promising approach is to protect quantum states by distributing quantum error correction over quantum networks. These networks consist of nodes that contain quantum bits to store and process quantum states, and that are connected by entanglement links based on photons. This approach is naturally scalable to larger sizes by connecting independent modules, and a wide variety of fascinating error correction codes is enabled by different network topologies. Pioneering experiments have demonstrated basic elements of quantum networks in various systems. However, due to the required precise understanding and control of complex quantum systems, protecting quantum networks against decoherence remains a major outstanding challenge in quantum science. The goal of this proposal is to demonstrate the detection of quantum errors over a 4-node quantum network. This network forms a unit cell that demonstrates all key principles for larger error-corrected quantum networks. This ambitious goal can now be pursued due to two advances by my colleagues and me using NV centers in diamond: (1) Entanglement of two NV centers through photons and (2) Complete control over multiple nuclear spins coupled to single NV centers. To realize the network, I will develop robust quantum memories, non-destructive spin measurements, and a precise microscopic understanding and control of coupled spin systems in diamond. Reaching this goal will be a potentially decisive step towards large quantum networks and distributed quantum computations: we will enter a new territory in which quantum states can be made more stable by making networks larger and larger, ultimately completely overcoming decoherence.

Keywords: the nv center in diamond,spin qubits,quantum information,quantum networks,quantum error correction
Unravelling the enigmatic origin of venom secreting cells in sea anemone (TentaclesOfVenom)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 182509.2
EU funding (EUR): 182509.2
Participants: 1
Project status: CLOSED

Evolution of venom, nature’s most complex cocktail, has underpinned the predatory success of venomous animals. Till date, research on venom has mainly focused on how genes encoding them evolve, and our knowledge regarding the evolutionary origin of venom-secreting cells (VSCs) and their secretions, has been limited. Understanding how venom and VSCs evolve in cnidarians - one of the simplest and probably the first venomous animals, such as sea anemones is not only fascinating as it sheds light on the evolution of their ancient venom-system, but may also be instrumental in the development of efficient nematocyte (stinging-cells) based drug-delivery tools. Identifying variation in venom-composition and sites of expression across various developmental stages and between the sexes (gender-specific expression) is also an understudied topic. The former is particularly intriguing in sea anemones, as their larval stages do not feed and yet synthesize toxins. Hence, in this project I propose to: trace the evolutionary origin of known VSCs (nematocytes and gland cells) in the starlet anemone, Nematostella vectensis, by constructing transgenic reporter lines; characterize venom-secretomes of VSCs using Fluorescence Assisted Cell Sorting (FACS) to determine the contribution of each VSC towards the venom arsenal; examine variation in venom-profiles and expression sites across the developmental stages and between the sexes using ‘omics’ technologies, in situ hybridization and immunostaining; test the biochemical activities (pharmacological assays) of the major and novel toxins identified; and examine the phylogenetic histories and the molecular evolutionary regimes of the major sea anemone toxins to understand the recruitment of genes into the envenoming function in one of the first venomous animals.

Keywords: venom secreting cells,evolution,cell differentiation,sea anemones,animal venoms