Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Learning from social scents: from territory to identity (sociOlfa)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-05-01
End date: 2025-10-31
Duration (months): 66.0
Total project cost (EUR): 1498875.0
EU funding (EUR): 1498875.0
Participants: 1
Project status: SIGNED

Olfaction is a central sensory modality in most Mammals as it supports vital functions such as feeding, mating and social interactions. Social chemosignals (olfactory cues from urine or body secretions) are efficient communication cues carrying important information such as territory ownership, resources’ locations and identity. Remembering such information is a key advantage for individuals allowing them to adapt their behaviors based on prior experience. However, how social chemosignals are processed and stored in the brain for future recall is still unclear. This project aims at identifying the brain-wide mechanisms underlying the contribution of social chemosignals to spatial and social memory in the mouse. The hippocampus is a key brain region for these two fundamental memory functions and it shares direct anatomical connections with the olfactory system that processes social odors. Using advanced computational methods and cutting-edge technologies that enable recording and manipulating large neuronal ensembles in freely moving mice, we will: - shed light on the mechanisms of spatial memory consolidation: we hypothesize that a dialog between the olfactory cortex and the hippocampus during sleep underlies the memory of an environment marked by social scents. - track the brain substrates of individuals’ identity in mice and their dependence on olfactory inputs: we hypothesize that during social learning, the response of neuronal circuits (1) reflects the unique olfactory signature of the encountered individual, and that (2) it changes as this individual becomes familiar. - test whether a coordination between olfactory and memory networks is essential to the formation of social recognition memory. Overall, this project will provide important insights on the network mechanisms of memory function and will contribute to our understanding of social behaviors.

Keywords: olfaction,social recognition,identity,memory,oscillations,spatial memory,consolidation,sleep,sharp wave ripples,hippocampus,piriform,lateral entorhinal cortex,population coding,electrophysiology,optogenetics
Gating mechanism and pharmacological modulation of nicotinic acetylcholine receptors (nAChR PAM-to-gate)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Pentameric ligand-gated ion channels (pLGICs), including nicotinic acetylcholine, 5HT3, glycine, and GABAA receptors, are membrane proteins specialized in the communication between neurons. These neurotransmitter receptors are the target of general anaesthetics, anxiolytics, alcohols and nicotine. In particular, enhancing the activity of neuronal nicotinic receptors holds promises in the treatment of pathologies including nicotine addiction, schizophrenia and Alzheimer’s disease. The current project aims at deciphering the molecular and pharmacological determinants of positive allosteric modulators of neuronal nicotinic receptors. We will over-express and purify these proteins, study their pharmacology through electrophysiology in cell lines and planar lipid bilayer, and surface plasmon resonance binding studies. Our study will provide insights into the molecular mechanisms of allosteric regulation, paving the way for the rational design of allosteric modulators with therapeutic potential.
Metal impacts on deep-sea microbial communities and function (MIDFun)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: SIGNED

Deep-sea mining of earth minerals is expected to grow in the next decades. The increase in deep-sea mining activities may lead to the release of toxic concentrations of metals into the surrounding seabed. Increased concentrations of heavy metals can disturb important ecosystem services provided by microbial communities, such as growth, nutrient cycling activity, and microbial diversity. However, the consequences of metal exposure on microbial ecosystem functions in deep-sea conditions are currently unknown. The overarching goal of this project is to evaluate the impacts of heavy metal exposure on microbial growth, metabolism, and diversity in deep-sea conditions. We propose the following specific objectives: 1. Determine the effects of heavy metal exposure on growth and N2O reduction metabolism in a model bacterial culture, under deep-sea conditions. 2. Examine the effects of heavy metal exposure on the transcriptome of a model bacterial culture, under deep-sea conditions. 3. Determine the impacts of heavy metal exposure on overall N2O fluxes from deep-sea sediments. 4. Evaluate the impacts of heavy metal exposure on the biological and functional diversity of deep-sea complex microbial communities. This research will apply a mixed experimental approach in controlled conditions to address the stated objectives. We will combine the use of bacterial axenic cultures with the study of complex microbial communities under deep-sea conditions (low temperature and high hydrostatic pressure). We will use pressurized bioreactors and hyperbaric chambers to test the effects of two representative metals (copper and cadmium) on bacterial growth, metabolic reduction of N2O, expression of functional genes, and functional diversity. The mining of the deep seafloor is still at an early stage of implementation. This research presents a unique opportunity to assess the environmental risks of an anthropogenic activity before it begins to shape the ecosystem.

Keywords: environmental microbiology,deep sea,metal pollution,nitrogen cycle,functional diversity
Making European research careers more attractive by developing new services and enhancing the current services of the EURAXESS network – EURAXESS TOPIII (EURAXESS TOP III)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Italy,Israel,Iceland,Albania,Germany,Spain,Ireland,Cyprus,Malta,Slovakia,Bosnia and Herzegovina,Switzerland,Serbia,Belgium,Bulgaria,Finland,Norway,Croatia,Lithuania,Slovenia,Moldova, Republic of,Türkiye,Greece,Poland,Romania,North Macedonia,Hungary,Latvia,France,Czechia,Netherlands,United Kingdom,Montenegro,Denmark,Luxembourg,Portugal,Portugal,Faroe Islands
Call: Trans-national operation of the EURAXESS Service network (H2020-SEAC-2014-1, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 3958271.19
EU funding (EUR): 3559043.0
Participants: 45
Project status: CLOSED

The EURAXESS TOP III consortium includes partners from almost all EURAXESS countries (either as beneficiaries or associated partners, from altogether 39 countries), in order to ensure the widest possible coverage as well as increased impact. The project has been divided into eight work packages. Two WPs are devoted to the development, testing and pilot introduction of new services on career development within the EURAXESS network. The remaining WPs will focus on the environment of researchers including the institutional context, the integration of third country researchers and reaching out to researchers beyond the EU; researchers within and outside academia, most notably industry; the consolidation of the ongoing services portfolio, be it personal or electronic; the further capacity building of the EURAXESS network members and meeting the challenge posed by staff turnover by trainings, twinning and study visits; networking and knowledge exchange with a wide range of other networks; implementation of a consistent quality assurance and monitoring system operating on several levels on the project, and working out a future vision for EURAXESS in light of the policy goals of the EC set for the period up to 2020. The project will significantly contribute to matching research talents with R&I needs and capacity on a European scale and it will help the circulation of researchers within Europe and among sectors. As a result of the project, members of the EURAXESS network will have better and broader knowledge and more integrated good practices regarding service provision for researchers. EURAXESS national portals throughout the EURAXESS member countries will offer tailor made information in line with Horizon 2020 objectives on making science careers attractive for researchers, especially young researchers.

Keywords: mobility of researchers,career development,euraxess,gender,jobs and funding opportunities
Multi-platform application toolkit (MPAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Italy,Italy,Germany,Germany,Finland,France,United Kingdom
Call: Technologies for creative industries, social media and convergence (H2020-ICT-2015, 2015)
Start date: 2015-12-01
End date: 2017-12-31
Duration (months): 25.0
Total project cost (EUR): 3295480.0
EU funding (EUR): 2980517.5
Participants: 8
Project status: CLOSED

The project will deliver MPAT – an extensible platform for the simple creation of interactive multi-media applications. In recent years the convergence of TV and online media has been increasing with dramatic pace. The boundaries between TV and personal media are dissolving rapidly. HbbTV is a key driver in this; enabling media companies to deploy interactive services for TV to a wide audience by building on top of a single standard. In many European markets, over 90% of Connected TVs, sold today, are HbbTV-enabled. Features including catch-up TV and interactive advertisements have already proved to be a great success because of their accessibility to the consumer and integration with the TV. Another recent milestone was the publication of HbbTV release 2.0, moving to state-of-the-art HTML5 and offering built in support for bi-directional multi-screen services as well as media and application synchronisation. Developing HbbTV applications from scratch requires considerable resources and for this reason they are often simply too costly for single formats or shows to contemplate. MPAT is the solution; motivated by a WordPress-like technical and business approach, MPAT makes application development affordable and sustainable while creating a new eco-system for content creators, theme and plug-in developers alike. With MPAT, media companies can semi-automatically author their set of customised applications that are then populated with content by the editorial staff or by linking MPAT to existing content management solutions. The open-source MPAT core will provide all the essential features to create compelling multi-screen experiences for HbbTV and other HTML5-based devices. The Consortium comprises key stakeholders from the HbbTV and media domain who will jointly deliver a sound and close-to-market solution thoroughly validated through an exhaustive set of pilots.

Keywords: application toolkit,hbbtv,production environment,creative industries
Increasing the security of access to urban critical infrastructure with a Near Field Communication micro SD smart card for mobile devices using on-chip state of the art technology (OneCard)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Slovakia
Call: Critical infrastructure protection topic 7: SME instrument topic: Protection of Urban soft targets and critical infrastructures (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-05-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

R-DAS, Ltd. presents OneCard, a microSD (uSD) card, and offers a full replacement of the classic NFC smart card by integrating the NFC antenna and secure elements (SE) into one uSD card. It maintains the memory of the uSD card and offers the highest (hardware) security for its users. The protection of critical infrastructure is a significant objective of the EU, and access control systems represent a considerable part of it. A major part of electronic access control systems use smart cards, which however are very impractical due to the number of these cards people use every day. Two SEs in OneCard assure hardware separation of application domains requiring extra safety, therefore it can be used instead of several smart cards. The NFC antenna and communication of our product are patented. There is no need to buy an expensive phone with NFC which results in great independence. With OneCard R-DAS can significantly advance together with the progressive growth of the NFC and access control market. Our business concept is based on B2B – our customers are providers of access control services and systems. Owing to OneCard, they may offer higher quality and cheaper services without the need of changing their technology and infrastructure. The final user of the card gains a more comfortable and safer way of access to tangible or virtual systems. The EU, as the third involved party due to safer access control gains a more protected critical infrastructure and earns goodwill of users adapting these systems.

Keywords: near field communication,access control and authentication systems,acaas,electronic access control,microsd card
The Genetics of Morbidity and Survival in Response to Significant Life Stressors (StressGene)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Iceland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2022-11-30
Duration (months): 66.0
Total project cost (EUR): 1998545.0
EU funding (EUR): 1998543.75
Participants: 1
Project status: SIGNED

Significant life stressors – including death of loved ones, being diagnosed with a life-threatening illness, and exposure to natural disasters or violence – are well-documented risk factors of ill health, disability and premature mortality. Why some individuals remain healthy while others remiss to adverse symptoms, disease or death after exposure to such life stressors remains unclear. The overarching aim of this research program is to advance current understanding of the potential genetic contribution to varying trajectories of health following exposure to significant life stressors. The program leverages the registries of major diseases and mortality covering the whole Icelandic nation (N=330.000) and the unique genetic- and genealogical resources at deCODE Genetics to perform genome-wide association studies (GWAS) on the varying risks of overall mortality and major diseases (including psychiatric disorders and cardiovascular disease) after loss of a family member or after receiving a cancer diagnosis. We will further seek to identify sequence variants associated with variation in symptoms of posttraumatic stress disorder (PTSD) in two highly traumatized cohorts: the SAGA cohort of 30.000 Icelandic women with high lifetime prevalence of violence exposure, as well as a cohort of 5.000 Swedes exposed to the 2004 SA-Asian Tsunami. This research program represents the first major attempt to address the potential genetic basis of varying somatic health outcomes after exposure to significant life stressors and, to our knowledge, one of the first comprehensive GWAS on PTSD in European populations. Virtually everyone is at some point in their life exposed to significant life stressors or trauma; the knowledge gained from this comprehensive research program may facilitate early identification and refined, personalized interventions for the most vulnerable individuals of the large populations worldwide that inevitably will continue to be exposed to trauma.

Keywords: stress,trauma,ptsd,survival,mortality,genetics
Grocerybot – AI-supported text dialog agent for communication with grocery stores in European languages (Grocerybot)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project will develop a business plan for the commercialisation of Grocerybot – a novel Artificial Intelligence (AI) powered chat bot supporting grocery shopping on-line. In recent months, the market has witnessed an exponential growth in the popularity of chatbots. This has been triggered by the actions taken by technology giants like Microsoft and Facebook who made it possible to release bots in their messengers such as Facebook Messenger. The market is dynamic and includes a number of still non-occupied niche areas where chatbots can solve unmet needs of business and technological nature. One such niche is on-line grocery shopping. Grocery shopping online continues to lag behind other domains, mainly due to issues with convenience. Typically, customers shopping for groceries on-line are required to fill their carts by clicking the products and defining the quantities. This process (ubiquitous in e-commerce) is very cumbersome in on-line grocery shopping. This is because of large number of items typically purchased and the need to define and review the quantities and weights of the products. A chatbot powered by AI technologies featuring machine learning, natural language processing and knowledge engineering could solve those problems by offering adequate customer assistance. However, no such technology has been proposed on the market to date. Loglab has been created to address this niche. We have a strong proof-of-concept of a grocerybot capable of guiding the user throughout the entire shopping journey online - a human-like assistant while shopping in an online grocery. The innovativeness of this concept has already been acknowledged by The National Centre for Research and Development in Poland which granted Loglab EUR 360K to develop the first commercial version of the bot for the Polish market. As a part of the Phase 1 project, we will develop a roadmap for scaling this innovation across the EU, powering the growth of online grocery retail in Europe.

Keywords: chatbot,on line grocery shopping,dialog systems techniques
RECYCLING BUSINESS MODELS (RBM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Sweden,Portugal
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2019)
Start date: 2019-10-01
End date: 2021-05-31
Duration (months): 20.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

An eco- industrial park is an area where businesses work together to optimize the use of resources. Waste from one company provides the raw material or energy for another. This synergy between industries fosters economic benefits while contributing to sustainable development. The main purpose of the project Recycling Business Models – RBM is indeed to investigate and analyse the possibility to transform traditional science and technology parks in more sustainable areas, to establish the basis of models of Eco science and technology parks. The principal objective of the project is indeed to create a methodology and a specific strategy to impulse especially the creation of new business opportunities for SMEs and the creation of new companies, based on the revalorisation of the wastes, equipment and its reincorporation in the life cycle of the companies located in science and technology parks. More than 80% of the companies located within technology park in Europe are SMEs, which create the majority of new jobs in the economy of these countries. The development and improvement of ecosystem of innovation support to SMEs is indeed crucial for the scale up of the companies and the creation of new jobs, including the recruiting of talent. RBM is based specifically on the opportunities for SMEs and companies the Circular Economy (CE) perspective can bring. New business models within this concept are beginning to deliver success and impact in terms of driving competitive benefits. Creating enterprises around sustainable models can improve both their environmental impact and competitiveness. Great opportunities are arising due to new consumer demands, environmental regulatory pressures and innovation challenges, and early SMEs adopters are likely to enter the market and attract investment so the project will investigate on the establishment of new strategies for the design and delivery of more adequate innovation support programmes for SMEs within the field of CE.

Keywords: innovation support programmes for smes,new business models based of circular economy,improvement of the economic and productive ecosystems