Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Vibrating carbon nanotubes for probing quantum systems at the mesoscale (MesoPhone)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 2748271.0
EU funding (EUR): 2748271.0
Participants: 1
Project status: SIGNED

Many fascinating quantum behaviours occur on a scale that is intermediate between individual particles and large ensembles. It is on this mesoscopic scale that collective properties, including quantum decoherence, start to emerge. This project will use vibrating carbon nanotubes – like guitar strings just a micrometre long – as mechanical probes in this intermediate regime. Nanotubes are ideal to explore this region experimentally, because they can be isolated from thermal noise; they are deflected by tiny forces; and they are small enough that quantum jitter significantly affects their behaviour. To take advantage of these properties, I will integrate nanotube resonators into electromechanical circuits that allow sensitive measurements at very low temperature. First, I will study the motional decoherence of the nanotube itself, by using it as the test particle in a new kind of quantum interferometer. This experiment works by integrating the nanotube into a superconducting qubit, and will represent a test of quantum superposition on a larger mass scale than ever before. It will answer a longstanding question of physics: can a moving object, containing millions of particles, exist in a superposition of states? Second, I will use the nanotube device as a tool to study superfluid helium 3 – the mysterious state of matter that may emulate the interacting quantum fields of the early universe. By measuring an immersed nanotube viscometer, I will be able to measure the behaviour of superfluid excitations on a scale where bulk superfluidity begins to break down. Third, I will add to the device a nanomagnet on nanotube springs, creating an ultra-sensitive magnetic force sensor. This offers a way to perform nuclear magnetic resonance on a chip, ultimately creating a microscopy tool that could image for example single viruses.

Keywords: carbon nanotubes,quantum optomechanics,superconducting devices,magnetic resonance
NEW MODELS FOR MACROPRUDENTIAL POLICY AND FORECASTING: THE EURO CRISIS (NAUTILUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2016-12-31
Duration (months): 18.0
Total project cost (EUR): 129357.9
EU funding (EUR): 129357.9
Participants: 1
Project status: CLOSED

As outlined in the Van Rompuy Report (2012), various potential models of monetary and fiscal union for Europe should be investigated and assessed, including different forms of shock-absorption mechanisms. In this context we explore new macroprudential policies for monetary and fiscal consolidation in the EU after the recent financial and sovereign debt crises, also in comparison with other major world economies in order to ensure long-term sustainability and the effective stabilisation of the Eurozone. Novel economic models are introduced and their applicability, forecastability, institutional characteristics and societal impact are evaluated.

Keywords: sovereign crisis,dynamic monetary union,macro financial spillovers,optimal regulation,moral hazard,dsge models,financial frictions,forecasting
Cavity Cooling of Nanosilicon for Quantum Interference Experiments (NANO-Q)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-16
End date: 2017-05-15
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

The ability to control and exploit the virtues of quantum physics is expected to revolutionize many areas of science and technology, from quantum information processing to quantum enhanced metrology. However, it is still a great challenge to observe quantum effects, such as superposition, in truly macroscopic objects. Matter-wave interferometry with very massive particles is a promising route towards testing the notions of macroscopicity and the still speculative limits of linearity in quantum physics. An intriguing goal in the community is to control the motion of mesoscopic nanoparticles, from 10^7 to 10^10 a.m.u., to the point where quantum interference can be observed. In this mass range collapse models and the role of gravity in quantum theory can be explored. It is a great challenge to control the motion of objects larger and more complicated than atoms and simple molecules. Recent proposals and experiments have begun the task, using optical cavities to cool the motion of nanoparticles, aiming to reach the level at which quantum effects are evident. The feasibility of this goal has been demonstrated experimentally by the Host Group, the Experienced Researcher and others, driven and supported by theoretical work. The NANO-Q project aims to create a source of free cavity cooled nanoparticles suitable for mesoscopic matter wave interferometry. It would be a great scientific breakthrough to observe quantum effects with such massive objects. Cooled nanoparticles will also be of great technological importance, as quantum transducers and precision force sensors .

Keywords: cavity cooling,optomechanics,nanotechnology,quantum physics,macroscopic quantum physics
Implantable nitinol net to combat pathological corneal shape deformations (HUMANeye)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Ireland,Italy,Spain,France
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2019-11-01
End date: 2023-12-31
Duration (months): 50.0
Total project cost (EUR): 1979801.84
EU funding (EUR): 1632797.0
Participants: 4
Project status: SIGNED

The global costs from visual refractive errors will reach some €1.2 trillion in 2019. This type of disability is on the increase and it is predicted that it will affect 10% of the World population by 2050. Pathological corneal shape deformations (PCSD) are a common cause of severe refractive error that tend to occur in young adults, considerably reducing both their quality of life and work productivity. Current treatment options are severely limited. The compromised cornea cannot withstand aggressive reductive laser surgery. Corneal transplantation gives highly unpredictable results, necessitating multiple operations that lead to spiraling treatment costs of over €14k per patient. HUMANEYE is a breakthrough dome-shaped corneal net fashioned in medical-grade titanium. Implanted deep within the cornea, it potently corrects refractive error and halts disease progression in PCSD. It uniquely matches the natural architecture of tissue layers throughout the entire tissue, leading to simple reproducible implantation, 70% higher success rates and 66% stronger refractive correction than current ring-shaped implants on the market today. The HUMANeye project unites two hi-tech SMEs, to manufacture the technology and push it to market, with two leading European ophthalmic care centres to prove its worth in the clinic. From HUMANEYE launch in 2023 until 2027, our SME partners will together generate €103.6m in cumulative revenues and €54.9m in profits. Rollout with an established commercial license partner will generate 21 internal and 48 external jobs in our value chain. 938k successfully operations will help 295k patients to better employment and save €20.1bn in direct public healthcare and indirect productivity costs.

Keywords: cornea,pathological corneal shape deformation,keratoconus,refractive error,myopia,laser eye surgery,corneal transplant,implant,titanium,laser micromachining,clinical trial
Informal Judicial Institutions: Invisible Determinants of Democratic Decay (INFINITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Czechia
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1999750.0
EU funding (EUR): 1999750.0
Participants: 1
Project status: SIGNED

Mainstream literature on courts focuses on formal rules. Yet informal judicial institutions, ranging from bureaucratic norms to clientelism, often shape judicial performance strongly. These institutions may even facilitate democratic decay. For example, various “gentlemen’s pacts” between judicial associations may substitute formal rules governing selection of judges, entrenching patronage and vertical gender segregation. Politically savvy chief justice can tweak the formal rules and forge alliances with politicians. Other informal judicial institutions may counteract democratic decay. For instance, judges may team up with journalists and mobilize the public to defend the judiciary. Recent literature has acknowledged these phenomena. However, the range of informal intra-judicial and extra-judicial institutions and their effects are not yet fully understood, as the traditional doctrinal and normative scholarship is not able to capture them. INFINITY fills this gap and addresses the implications of this phenomenon for the “new” and “old” EU member states, and the neighbouring countries. The central research question of INFINITY is: How do informal judicial institutions affect functioning of the judiciary and under what circumstances they counteract or contribute to democratic decay? INFINITY builds on a comparative legal perspective combined with sociological and political science approaches. It consists of 4 interrelated research aims: The first aim is to identify the most important informal judicial institutions in 16 European jurisdictions. The second aim is to assess their impact, positive or negative, on the domestic judiciaries, including their gender aspects. The third aim is to analyse supranational influence of EU and CoE on informal judicial institutions. The fourth overarching aim is to synthetize previous findings on the dynamics of informal judicial institutions into an overarching theory on the role of informal judicial institutions in democratic decay.

Keywords: courts,judges,informal institutions,judiciary,democratic decay,populism,judicial corruption,post communist countries,europe,court packing,gender,european union,council of europe
DISCOVERing treatment from biomedical research (DISCOVER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Denmark
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 3905280.0
EU funding (EUR): 1952640.0
Participants: 1
Project status: SIGNED

DISCOVERing treatment from biomedical research (DISCOVER) is a doctoral programme, to be led by the Biotech Research and Innovation Centre (BRIC) at the University of Copenhagen. BRIC is a Centre of Excellence, with a primary goal of performing cutting-edge basic biomedical research in an open and diverse environment fostering interdisciplinarity and collaboration. Further, BRIC aims to offer outstanding research training of young scientists and translate research findings into societal value. In DISCOVER, we will recruit 24 outstanding international fellows to perform their PhD-projects in our state of the art laboratories in collaboration with a number of clinical environments. Our VISION is to empower diverse research talent to become creative and responsible researchers, with an ability to translate their biomedical research into clinical value. The past decades have presented great breakthroughs in the fundamental knowledge required for understanding and diagnosing many diseases. However, the ability to move basic discoveries towards new treatments is lagging behind the pace of discovery. DISCOVER’s ambition is to inspire and enable fellows to a research career bridging basic and clinical research. This will be done as a joint venture between BRIC and a number of clinical partner organisations. Three programme CORNERSTONES are central to pursue the vision: • Build bridge across ‘bed and bench’ • Discover approaches and tools to stimulate creativity and translation of research • Explore and implement sustainability in biomedical research With DISCOVER we will address an unmet need for closer ties between basic research and the clinic, through education of translational researchers with abilities move basic biomedical research findings down the path towards treatment. To widen their career perspectives, fellows will reflect on own competences and career goals and individually choose translational skill training and career activities to reach their goals

Keywords: biomedicine,translational research,cancer,neurobiology,metabolic diseases,laboratory sustainability,research creativity
Quaternary Amino Acids on Scale for Medicine and Agroscience (QUATERMAIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2016-11-01
End date: 2018-04-30
Duration (months): 18.0
Total project cost (EUR): 149918.0
EU funding (EUR): 149918.0
Participants: 1
Project status: CLOSED

Enantiopure quaternary amino acids, carrying two carbon-based substituents at the α carbon, are one of the most important groups of modified α amino acids, of great commercial value in the development of new pharmaceuticals and agrochemicals. Certain of these quaternary amino acids are readily available by stereoselective α alkylation of available amino acids, but not those functionalized by the addition of α-aryl groups. In this project, we propose to develop an industrially scalable, practical method for the synthesis of α-arylated quaternary amino acids in enantiomerically pure form by streamlining, optimization and scale-up of a reaction we discovered while working on the synthesis of quaternary amino acids as conformational controllers within an ERC-funded Advanced Grant. The method is operationally simple and employs only inexpensive commodity chemicals as precursors. It uses no chiral auxiliary or catalyst, and exploits both structure and stereochemistry of the starting amino acid to make the quaternary amino acids in enantiomerically pure form. It avoid the use of transition metals, freeing the method from the potential problems associated with their toxicity, cost and volatility of supply. The nearest competitive methods are either limited in scope to electron-deficient aryl rings, or they employ toxic and expensive transition metal catalysts. Interest in the method has been garnered from the fine chemical, pharmaceutical and agrochemical industry, but further work on scale-up and practical issues are needed for the technology to become industry-ready. In parallel with this main thrust of the project, we will carry out preliminary work on related chemistry, developing a new, simple route to analogues of arogenate into a practical method for the synthesis of a new agrochemical targets of potentially very great commercial interest. The ready availability of these compounds will offer significant potential for future agrochemical innovation.

Keywords: amino acid,peptide,synthesis,quaternary,aromatic,chemistry,agrochemical,pharmaceutical,medicinal,arogenate,biosynthesis,tyrosine
Collaboration Network for Industry, Manufacturing, Business and Logistics in Europe (NIMBLE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Israel,Italy,Italy,Italy,Austria,Sweden,Türkiye
Call: Digital automation (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2020-03-31
Duration (months): 42.0
Total project cost (EUR): 7994750.0
EU funding (EUR): 7994750.0
Participants: 21
Project status: CLOSED

NIMBLE: collaboration Network for Industry, Manufacturing, Business and Logistics in Europe will develop the infrastructure for a cloud-based, Industrie 4.0, Internet-of-things-enabled B2B platform on which European manufacturing firms can register, publish machine-readable catalogs for products and services, search for suitable supply chain partners, negotiate contracts and supply logistics, and develop private and secure B2B and M2M information exchange channels to optimise business work flows. The infrastructure will be developed as open source software under an Apache-type, permissive license. The governance model is a federation of platforms for multi-sided trade, with mandatory interoperation functions and optional added-value business functions that can be provided by third parties. This will foster the growth of a net-centric business ecosystem for sustainable innovation and fair competition as envisaged by the Digital Agenda 2020. Prospective NIMBLE providers can take the open source infrastructure and bundle it with sectoral, regional or functional added value services and launch a new platform in the federation. Internet platforms need fast adoption rates and the work plan reflects this: we start attracting early adopters from day one and develop the initial, working platform in year one. Added-value business functions follow in year two and final validation at large scale, involving hundreds of external firms, will happen in year three. Our adoption plan is designed to enable two or more platform providers at the end of the project, and to have 1000 to 2000 enterprises connected to the overall ecosystem at that point. NIMBLE has 17 partners grouped around 3 main activities: developing the infrastructure, running a platform adoption programme, and validating the platform with 4 supply chains (white goods, wooden houses, fashion fabrics, and child care furniture). NIMBLE will give manufacturing SMEs in Europe a stable and sustainable digital ecosystem.
Identification of genes and pathways regulated by the HAT activity of MOZ (HAT-MOZ-sphere)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The research programme will comprise the study of the Histone acetyl transferase (HAT) MOZ (Monocytic leukaemia Zinc finger) a critical player in the development and maintenance of the haematopoietic system. In addition, translocations of MOZ are associated with Acute Myeloblastic Leukaemia. Given the importance of this protein in haematopoiesis and leukaemogenesis, it would be essential to further understand the function of MOZ and in particular to identify the genes regulated by its HAT activity of MOZ. A mouse line specifically mutated to abrogate the HAT enzymatic activity of MOZ has been developed in the host laboratory, and represents a powerful and unique tool for the study of MOZ HAT activity. Using Chromatin ImmunoPrecipitation followed by sequencing (ChIP-seq), genome wide targets of MOZ will be determined and the consequences of the deletion of its HAT activity on the epigenetic landscape will be investigated through the survey of several histone modifications and RNA polymerase II recruitment. The non-histone targets of MOZ will be identified through the SILAC technique. Finally a MOZ murine leukaemic model has been developed, based on the transduction of bone marrow cells with a retrovirus encoding MOZ-TIF2, one of the fusion proteins involving MOZ. ChIP-seq will be performed in these leukaemic cells to identify genes targeted by MOZ-TIF2 and changes in epigenetic marks at these loci. Overall, this project will provide a better understanding of MOZ HAT activity in haematopoiesis and leukaemogenesis. Crucially, this project will enable Dr Anne Largeot to obtain and develop a wide range of new and transferable skills through a variety of multidisciplinary training programs. Relying on the knowledge and expertise of her supervisor and the exceptionally high calibre of the Cancer Research UK Manchester Institute, this project will enable Dr Anne Largeot to achieve her long-term objective of obtaining a leadership position in a competitive European Institute

Keywords: moz hat haematopoiesis leukaemogenesis