Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next generation Sepsis pathogen diagnostics: Revolutionary device for rapid detection of Sepsis (SepTec)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-04-01
End date: 2023-12-31
Duration (months): 33.0
Total project cost (EUR): 3455250.0
EU funding (EUR): 2418675.0
Participants: 1
Project status: SIGNED

49M patients are diagnosed with Sepsis and 11M die annually worldwide and costs over €30 billion to treat. This is a senseless tragedy as 80% of sepsis deaths could be prevented with rapid diagnosis and treatment. SepTec is the groundbreaking, cost-effective technology required to provide the solution. SepTec is a patent-pending in-vitro diagnostic device that screens blood for the diagnosis of sepsis infection, detecting and identifying pathogens within 15 minutes at very low concentrations (<10 CFU/ml) without the need complicated lab tests. Preliminary health economics research shows that our rapid Sepsis infection diagnosis will result in patients receiving the correct treatment between 2 and 4.5 days earlier than in current protocols (resulting in a consequent 50% reduction in mortality rate), 25 times fewer patients receiving unnecessary antibiotics and a healthcare saving between €17-40m per 5m population. The global point of care market is expected to be valued €50.51bn by year 2026, (CAGR of 9.6%). Within this market, the market for point-of-care tests (POCT) for infectious diseases (including sepsis) is €3.7bn annually and sepsis specific POC diagnostics testing market is expected to grow from €1bn by 2026. To exploit this lucrative market opportunity, we must complete an innovation project to progress our highly promising results into a product suitable for a large-scale clinical validation, mass manufacturing and subsequently commercialization.

Keywords: sepsis,infection diagnostic,near patient,cell biology,bacteriology
Redefining the carbon sink capacity of global forests: The driving role of tree mortality (TreeMort)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Sweden,Netherlands,United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1493970.0
EU funding (EUR): 480460.29
Participants: 4
Project status: SIGNED

Everything that lives must die. Yet when it comes to the world's forests, we know much more about the processes governing their life than those governing their death. Global forests hold enormous amounts of carbon in their biomass, which has absorbed about 20% of anthropogenic carbon dioxide emissions over recent decades. Whether the size of this sink will persist, intensify, decrease or even become a source is highly uncertain, yet knowing this is crucial to the calculation of carbon emission budgets consistent with limiting global temperature rise. One of the most compelling explanations for this uncertainty is a lack of knowledge of how tree mortality affects forest carbon storage on a global scale. Mortality rates and mechanisms are closely tied to forest structure and composition, and thus the storage of carbon in biomass, but mechanistic complexity and the difficulty of measurement have hindered understanding, resulting in a striking lack of consensus in existing assessments. TreeMort will remedy this, combining newly available sources of data with appropriate conceptualisation and innovative modelling, to provide quantifications of the rates and causes of tree death, and their relation to environmental drivers, that set new standards for robustness, comprehensiveness and consistency at the global scale. This breaking-out of the narrower foci of previous work will be a game-changer, finally enabling globally-comprehensive investigation of the extent to which whole forest structure and function are governed by and interact with mortality, and their likely evolution under environmental change. TreeMort will assess this using state-of-the-art ecosystem modelling, which will then be employed to make a fundamental reassessment of the current and future carbon storage capacity of global forests. TreeMort will thus bring us significantly closer to understanding fully how forests interact with the global carbon cycle, assisting efforts to mitigate climate change.

Keywords: terrestrial carbon cycle,terrestrial carbon sink,tree mortality,vegetation dynamics,forest structure,global,terrestrial biosphere modelling,carbon turnover
Bile acid, immune-metabolism, lipid and glucose homeostasis (ImmunoBile)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 5
Project status: CLOSED

The role of chronic inflammation in obesity, metabolic and cardiovascular diseases is increasingly recognized. Bile acids (BA), synthesized in the liver and modified by the gut flora, facilitate lipid absorption in the intestine. BA modulate lipid and glucose homeostasis by activating the nuclear receptor FXR and the GPCR TGR5. Intriguingly, peripheral BA concentrations are elevated in type 2 diabetes (T2D) and FXR mediates the beneficial metabolic response to gastric bypass in mice. The immune system plays an important role in the cross-talk with metabolic tissues, such as liver, intestine and adipose tissues. However, whether BA modulate immune cell function is unknown. Our unpublished results identifying FXR and TGR5 expression in lymphoid cells, prompt us to study their role in the regulation of glucose and lipid metabolism through immune cell modulation. Using reporter mice and specific ligands, we will characterize the immune cells expressing active FXR and TGR5. We will determine their role in metabolism and inflammation by immune cell-specific gene inactivation in models of obesity, T2D and elevated peripheral blood BA concentrations. Mass cytometry, cell sorting and single cell transcriptomic analysis will allow the identification of gene networks regulated by BA and their receptors. As microbiota generate biologically active secondary BA, we will assess the impact of microbiota depletion and subsequent BA acid pool modifications on immune cell populations. Translational studies in humans with altered BA metabolism and pharmacological treatment with anti-diabetic BA sequestrants will allow assessment of alterations in immune functions. This project aims to identify an hitherto unexplored role of BA through modulation of the immune system on T2D, NAFLD and dyslipidemia. Success of the project critically depends on an integrative approach uniquely undertaken in my laboratory through its unique multidisciplinary expertise in basic and translational biology.

Keywords: bile acid,nuclear receptors,inflammation,lymphocytes,type 2 diabetes,obesity,liver diseases
Ant navigation: how complex behaviours emerge from mini-brains in interaction with their natural habitats (EMERG-ANT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2024-06-30
Duration (months): 78.0
Total project cost (EUR): 1439893.0
EU funding (EUR): 1439893.0
Participants: 1
Project status: SIGNED

Navigation is one of the most crucial and most challenging problems animals face. Behavioural analyses have shown that animals make use of a number of different mechanisms to navigate, but very little is known of how spatial information is processed and integrated by the brain. This project will exploit the stunning ability of ants in learning long visual routes to investigate the mechanisms of navigation in a brain numerically much simpler than vertebrate. We will combine an ecological approach with state-of-the-art technologies to enable a thorough control of sensory-motor cues while the ant is navigating in virtual-reality reconstructions of its natural environments. This new and powerful method will enable us to dissect the mechanisms underlying the emergence of navigational behaviours by performing straightforward manipulations. The results will be modelled in the light of insect neurobiology and integrated into an increasingly complete neural architecture. This neural architecture will be embedded into an agent navigating in the same virtual-reality environment as the real ants for testing. The advantage of such an inter-disciplinary approach is that failures of our agent will help us identify gaps in our knowledge and thus fuel new experimentation. Reciprocally, our agent will become increasingly refined in the light of incoming experimental results. This will create a positive feedback towards a complete, multi-level understanding of navigation in the wild. The findings will inspire new robust solutions for navigational problems that can be applied to bio-robotics.
Open data: improving transparency, reproducibility and collaboration in science (OPTIMISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 265606.08
EU funding (EUR): 265606.08
Participants: 2
Project status: CLOSED

Science is facing a reproducibility crisis, whereby many research results, including landmark studies, cannot be independently reproduced. As a consequence, scientific progress is slowed and entire research fields can be misguided. Finding a meaningful solution to this crisis requires increasing transparency and collaboration among researchers to ‘OPTIMISE’ how we conduct science. I will study the role and importance of open data as a means of achieving this goal. Making research data openly accessible to other scientists and the public has many societal benefits, including validating research results and accelerating discoveries. However, open data is controversial among researchers, mainly because of perceived individual costs. Furthermore, we lack empirical research on the efficacy of open data practices at resolving the reproducibility crisis. By combining approaches in social and natural sciences, this action will address this knowledge gap in an interdisciplinary fashion via two overarching objectives: A) Assess whether open data policies result in high-quality data sharing and reduce poor scientific practices; B) Investigate the barriers and motivations behind decisions to adopt open data practices. I will focus on the field of ecology and evolution (my background) and examine: 1) the efficacy of editorial policies mandating open data, 2) the influence of open data practices on the quality of research results, 3) challenges and solutions to sharing sensitive data, 4) barriers to good open data practices, and 5) individual motivations for sharing data. The data to answer these questions are readily collectable and reciprocal knowledge transfer will directly benefit both the hosts and the candidate. Deliverables will help elucidate the barriers and benefits of open science practices to improve research transparency, reproducibility and discovery. These goals support H2020’s objective to facilitate innovation and growth while maintaining scientific integrity.

Keywords: data sharing,open science
Effects of multi-scale rough patches on hydrodynamics and scalar dispersion in turbulent boundary layers (Turb. Bound. Layers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-11-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The objective of the proposed research initiative is to experimentally investigate the effects of irregular multi-scale wall roughness on turbulent boundary layers. It is widely understood that wall roughness has a significant effect on turbulent boundary layers, however the majority of the existing research on this complex mechanism has been limited to homogeneous distributions of roughness covering the entire surface. Current models fall short for the majority of real-world flows that develop over surfaces with natural irregularities such as flows over ship hulls containing barnacles or atmospheric flows over cities or forests. In this proposed research, a range of experiments will be carried out to investigate the flow around custom-manufactured patches of wall roughness placed within a turbulent boundary layer. Wall roughness elements will be designed using fractal patterns in order to isolate the multi-scale effects of the roughness geometry. Measurements will be performed in a wind tunnel and in a water channel at the University of Southampton (UoS), using a force balance to directly measure the wall friction, particle image velocimetry to measure the local flow structure, and planar-laser-induced fluorescence to measure the local dispersion for a variety of different patch topologies. This work will further the fundamental understanding of turbulent boundary layer flows and will have practical relevance to environmental, transportation, and energy engineering by setting the groundwork for the understanding and parameterization of multi-scale roughness effects. This ambitious research initiative will be achievable by leveraging the combined expertise of the proposed Fellow in experimental fluid dynamics and turbulent shear flows and the expertise of the UoS in aerodynamics and turbulent boundary layer research.

Keywords: experimental fluid dynamics,turbulence,boundary layers,drag reduction,wall roughness,turbulent dispersion,wind tunnels,particle image velocimetry
Self-installable device that converts intercoms into a smart keys to allow access from anywhere. (Nello One)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A rising number of customers are becoming increasingly accustomed to convenience. People are buying more and more online – the e commerce market reached €1.9 trillion worldwide in 2018, a 26% jump from 2016. As such, retailers now need to compete on convenience as well as price. Nevertheless, delivery is the biggest challenge to e-commerce. Though access control is seen to be more convenient for delivery options, it is fraught with difficulties. Nello One is the only plug and play smart lock solution that gives hallway access at a highly affordable price. It is a smart upgrade for intercoms that works with a Wi-Fi-enabled chip to transmit the bell and door buzzer signals of intercoms via Wi-Fi to the cloud. The Nello One app is connected with our cloud so the app informs users when someone has buzzed and after they give permission, Nello One instantly opens the hallway door – no matter where they are. Nello One is uniquely placed within the housing access market -there are 220M households in Europe giving us huge potential market. Our management team is made of the 5 co-founders and a new employee. This product idea originally started in November 2014 followed by a successful Kickstarter campaign in 2015 and in 2017 we registered an annual turnover of €192,540 with a balance sheet showing €1.68M. Prior to this, we raised capital from a range of different investors. We are now seeking for a further investment of €1.5M to further develop the technology, run a large pilot test and redefine value chain in order to optimise the production and penetrate a larger market. The proposed work in Phase 1 of the SME Instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of Nello One and its market uptake.

Keywords: smart locks,intercoms,access control
REVEALING THE ROLE OF GEOSS AS THE DEFAULT DIGITAL PORTAL FOR BUILDING CLIMATE CHANGE ADAPTATION & MITIGATION APPLICATIONS (EIFFEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Germany,Greece,Greece,Lithuania,Finland,Switzerland,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Integrated GEOSS climate applications to support adaptation and mitigation measures of the Paris Agreement (H2020-LC-CLA-2020-2, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 4999466.25
EU funding (EUR): 4999466.25
Participants: 20
Project status: SIGNED

EIFFEL will offer the EO-based community the ground-breaking capacity of exploiting existing GEOSS and external datasets, with minimal new data collection activities. Added-value services interoperable with GEOSS will be designed, using cognitive search and metadata augmentation tools based on Artificial Intelligence (AI), including Natural Language Processing. These tools will leverage advanced cognitive features to extract meaningful information from and enrich GEOSS metadata. Moreover, novel methods (super resolution, data fusion) for augmenting the spatiotemporal resolution of explored EO data will be proposed, in order to address the needs of the diverse EIFFEL CC adaptation and mitigation applications. The latter will cover: (i) a set of five different GEO Societal Benefit Areas (SBAs), namely in Water and Land Use Management, Sustainable Agriculture, Transport Management, Sustainable Urban Development and Disaster Resilience domains; (ii) various EU geographical and climatic regions, at local, regional, national, cross-border and pan-European scales. Further, the value of using explainable AI techniques for improving the credibility and comprehensiveness of such CC applications, so that they can offer actionable insights to the decision makers, will be showcased. EIFFEL will foster the co-design of CC adaptation policies and mitigation strategies and monitor CC effects in the respective regions. The project, in line with EuroGEO’s emphasis on early engagement with stakeholders and their participation in the application design, has ensured that they are active consortium members. EIFFEL complies with the framework of results-Oriented GEOSS, to improve the delivery of applications tailored to decision making centres and will actively participate in the GEO Work Programme post-2019. Last, it provides tangible proof of the value of GEOSS data for creating CC applications and encourages projects and initiatives to offer their data through the portal.

Keywords: climate change adaptation and mitigation,geoss,eurogeo,copernicus,paris agreement,sendai framework,un sdgs,artificial intelligence,spatiotemporal resolution,clms,communities of practice
Microcontact. Language variation and change from the Italian heritage perspective. (MicroContact)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1996250.0
EU funding (EUR): 1996250.0
Participants: 1
Project status: CLOSED

This project aims to add an important block to syntactic theory, by developing new theoretical tools to account for microvariation and change. The central idea is that change and microvariation are necessary parts of grammar, and that they are in fact constrained by Universal Grammar (Chomsky 1957 ff.); in order to understand them we need not focus on the starting point and endpoint of change only, but also on the process itself. Observing change in progress can offer insights into its causes and the mechanisms underlying it. We aim at getting snapshots of change in progress by examining endogenous, diachronic change and change in contact for a number of genetically and typologically related varieties. Between the end of the 19th c. and the 1920s, many Italians migrated to the Americas. After World War II, a third wave of migration took place: around 400.000 people left Italy between 1950-1960. Interestingly, most of these Italians did not speak Italian as their native language: they all spoke some “dialect”. With this term we traditionally refer to those Romance languages spoken in Italy that evolved from Latin, and are sister languages to standard Italian. When these immigrants moved across the Atlantic, their languages entered in contact with other Romance varieties, like Argentinian Spanish, Brazilian Portuguese, or Québécois French, as well as with English. The languages spoken by these 1st generation immigrants, who are now very old, are extremely important, as they potentially give a unique window into the mechanisms of language change in general, and of syntactic change in particular.

Keywords: microvariation,language variation,syntactic theory,language change,diachrony,italian dialects