Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Manipulating Arm movement Preparation via a comPuter Interface for Neural decodinG (MAPPING)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

Our daily behaviors critically depend on our ability to execute carefully planned movements. While motor planning is known to rely on the motor cortex, the logic by which specific patterns of neural activity in the motor cortex contribute to the planning of a movement remains unknown. Addressing this issue is not only central to our understanding of the brain, but may also lead to concrete advances in neuroprosthetics. A recent theory of motor planning proposes that neural dynamics in the motor cortex acts as a dynamical system whose state is optimized via a putative “corrective” mechanism during the planning phase of the movement. While this theory has had a profound impact on the field, empirical evidence corroborating the existence of such a mechanism is crucially lacking. In this proposal, I devise a 3-step approach to fill this experimental gap and test key predictions of the theory. First, I will design a behavioral task in non-human primates to probe the neural basis of motor planning. Second, using this task, I will characterize baseline motor cortical dynamics during normal movement preparation. Finally, I will selectively perturb neural dynamics to assess the existence of a corrective mechanism within the motor cortex. This manipulation will rely on a highly innovative approach based on brain-computer interfaces (BCIs) to perform targeted perturbations of neural activity. The project will combine the technical expertise of the host laboratory in motor control with my own expertise in complex neural data analyses acquired during my PhD. Both the host and I will benefit from the project. I will acquire technical and managerial skills I intend to leverage in my future research. In turn, I will bring a set of new analytical tools in the host team to complement and expand their existing research. The project will be a major step in the direction of my future scientific agenda, and will strengthen my application for a permanent research position in France.

Keywords: neural population dynamics,electrophysiology,non human primates,motor cortex
Multifaceted stability behaviour of a HYperloop vehicle at high SPEED (HySpeed)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-15
End date: 2025-12-14
Duration (months): 30.0
Total project cost (EUR): 254330.4
EU funding (EUR): 254330.4
Participants: 2
Project status: SIGNED

With a target speed of 1000 km/h, Hyperloop holds the promise of being a fast, clean and energy efficient mode of transportation. The speed is unprecedented for ground-borne transport; the magnetically suspended Hyperloop vehicle offers travelers the speed of an aircraft combined with the convenience of a train. It can carry time-sensitive goods as well, providing a sustainable alternative to airfreight. The understanding and control of the interaction between the vehicle and the surrounding environment (magnetic suspension, infrastructure, air) is fundamental to the technical feasibility of Hyperloop and will be thoroughly addressed in this project. More specifically, the project will examine the vibration of the vehicle while travelling at very high speeds through a tube, to guarantee safety and comfort. Three forces – the magnetic interaction force, the aeroelastic force and the reaction force delivered by the supporting infrastructure – act simultaneously and may destabilize the vehicle vibration through complex nonlinear interactions, creating a multifaceted stability problem. This project will investigate the multifaceted stability behavior in depth to gain understanding regarding the interplay of the destabilizing forces (which becomes particularly pronounced at the very high speeds envisioned), to evaluate the suitability of the state-of-art control (stabilization) measures, and to devise an improved, optimal controller. The project comprises model development as well as experimental validation, which will be done during a non-academic placement at Hardt Hyperloop. Access will be given to the European Hyperloop Centre, a unique 2.6 km long test facility which enables testing at high speeds. Results of this project will be very relevant for the design of the Hyperloop suspension and infrastructure, for magnetically levitated train systems, as well as for high-speed rail. The results will also advance the scientific field of nonlinear dynamics in general.

Keywords: nonlinear dynamics,vibration,wave propagation,interacting instability mechanisms,stability transition,electromagnetism,aeroelasticity,structural dynamics
Automated Mass Production of SOC Stacks (AMPS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Finland,Estonia,Germany,Netherlands,Czechia,Italy
Call: Design and industrial deployment of innovative manufacturing processes for fuel cells and fuel cell components (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 8711520.0
EU funding (EUR): 6606098.26
Participants: 12
Project status: SIGNED

AMPS project brings together the leading European companies in Solid Oxide Fuel Cell and Solid Oxide Electrolyzer manufacturing value chain. The project includes automation companies (Rocksoft, Smartal) and manufacturing equipment producers (SITEC, Haikutech, Dosetec) as well as cell manufacturer (Elcogen AS) and stack manufacturer (Elcogen oy). The project is motivated by their strong commitment to develop their products and services and commence real mass-manufacturing. The industry partners are supported by research institutes VTT, Polito and VUTS. The high-level AMPS objectives are: 1. Automated high-speed cell production with integrated quality control 2. Automated high-speed interconnect plate production and coating with integrated quality control 3. Automated high-speed stack assembly with integrated quality control 4. Complete component tracking and optimized mass-manufacturing by using virtual twins 5. Assessment and demonstration of target stack manufacturing cost of <800 €/kWel at production volume of 100 MW/year 6. Establish European supply chain of SOC manufacturing equipment Successful dissemination of the AMPS results is in the core of the participating companies business, as they are selling stack components and associated manufacturing equipment for many other companies than just AMPS partners and therefore want to spread the knowledge of the developed solutions and manufacturing methods and equipment.

Keywords: hydrogen,fuel cells,electrolyzer,manufacturing,quality control
Mechanisms and Functions of Brain- Body- Environment Interactions in C. elegans (elegansBrainBodyEnvi)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 3500000.0
EU funding (EUR): 3500000.0
Participants: 1
Project status: SIGNED

Recent large-scaRecent large-scale neuronal activity recordings in awake, behaving animals revealed a new, unexpected neuroscientific principle: widespread neuronal activity patterns across the brain encode parameters of movement. Surprisingly, these brain-wide behavior representations even extend to areas that are implicated in the processing of sensory information (e.g., the visual cortex in mice). Thus, a large fraction of the brain’s activity seems to be dedicated to representing the animals current, ongoing behavior. These observations have been made across the animal kingdom including worms, flies and mammals, suggesting a universal principle; however, the underlying mechanisms and functions remain unknown. In this proposal, we take advantage of the tractable model organism C. elegans to tackle this problem, combining brain-wide single cell resolution Ca2+-imaging in freely behaving animals with genetic circuit manipulation tools. It was previously recognized that the brain operates in a closed loop, actively sensing its body and its environment and making predictions of movement outcomes to optimally control behavior. Here, we propose to reconcile these long-standing concepts with the new observations of brain-wide behavior representations. Our core hypothesis is that sensory to motor transformation is a distributed process incorporating multiple functions like gain-control, re-afference prediction and predictive processing. Our team is at the forefront of scientific innovation and discoveries in this field, and we thereby are making substantial contributions to this currently ongoing paradigm shift in our understanding of how the brain operates. Studying these phenomena in worms offers a unique and timely opportunity to rapidly uncover the universal functions of brain wide behavioral representations. We therefore aim to make fundamental predictions and to formulate new working hypotheses for similar studies in larger model organisms with more complex brains.

Keywords: calcium imaging,neuronal network dynamics,motor control
Development and evaluation of Radical Oxygen Species (ROS)-responsive drug delivery systems to prevent and cure inflammatory and hypoxic diseases. (ROSCURE-O2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

The evolving landscape of medical research demands innovative breakthroughs to enhance disease treatments. Smart drug delivery systems (DDS) are at the forefront of these innovations, offering precise drug release while combatting oxidative stress and harmful species. ROSCURE-O2 (Radical Oxygen Species (ROS)-responsive drug delivery systems to prevent and cure inflammatory and hypoxic diseases), is a pioneering proposal focusing on engineering ROS-responsive DDS with anti-inflammatory and anti-hypoxia properties.Inflammation profoundly affects global health, contributing to various skin and wound conditions, including radiation-induced skin injuries (RISI). RISI arises from healthy cells' exposure to ionizing radiation used in cancer radiotherapy, leading to issues ranging from mild skin reactions to severe burns, ulcers, infections, and necrosis, impacting the quality of life for over 95% of radiotherapy patients. ROSCURE-O2 aims to develop innovative treatments for inflammatory conditions by targeting ROS and hypoxia precisely. The hypothesis posits that multifunctional DDS can (1) scavenge ROS, (2) selectively release anti-inflammatory drugs, and (3) deliver oxygen in ROS-rich environments, thus preventing and curing inflammatory diseases. This triple therapeutic approach seeks to overcome the limitations of conventional treatments. Within ROSCURE-O2 the development of a Smart DDS platform that can synergistically address ROS and hypoxia. This involves polymeric DDS with ROS-responsive properties, provided by sulfur-based chemistries and/or antioxidant crosslinkers and the incorporation of oxygen-releasing and ROS-scavenging nanoparticles, like Cerium Oxide. These nanoparticles can be combined with anti-inflammatory active pharmaceutical ingredients to increase treatment efficacy and reduce costs. ROSCURE-O2's outcomes have the potential to advance our understanding of ROS-responsive drug delivery and tissue regeneration through oxygen delivery.

Keywords: drug delivery,stimuli responsive drug delivery,ros quenching,antioxidant treatments,oxygen delivery
Bridging epidemic modelling and phylogenetic methods to understand avian influenza transmission in poultry trading networks (EPHYFLU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-02
End date: 2026-10-01
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

Poultry production has risen as the main livestock sector worldwide, with this growth being primarily driven by low and middle income countries such as Bangladesh. Unfortunately, the high circulation of avian influenza in domestic flocks undermines economic and societal benefits of poultry production in this country and raises significant concerns for human health. Nonetheless, avian influenza transmission in Bangladeshi poultry remains poorly characterised. To fill this gap, the EPHYFLU project will shed light on the transmission patterns of H9N2 avian influenza virus, the most common strain in Bangladesh, by combining state-of-the-art mechanistic models and high quality sequence data. In particular, this project will develop novel methods to leverage genomic data to inform epidemic models, which will be used to assess the effectiveness of a range of veterinary public health interventions aiming to reduce H9N2 avian influenza transmission. This program will result in novel policy recommendations for avian influenza control in Bangladesh, and contribute to the integration of phylogenetic and mechanistic modelling.

Keywords: avian influenza,epidemiology,agent based models,phylogenetics,phylodynamics,bayesian inference
ecO-evolUTionary dynamics in COMmunitiEs (OUTCOME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: TERMINATED

Host-parasite communities compose networks of interacting individuals of different species. These communities are constantly coevolving, i.e. reciprocal selective pressures. Coevolution produces ecological changes, such as dynamics in demographies or in the distribution of interactions. Such ecological changes may feedback to drive further evolution in the communities. However, coevolutionary research usually focuses on isolated host-parasite pairs, assuming that the ecological effects can be ignored. Similarly, ecological studies argue that coevolution is not fast enough to affect ecological processes. Hence, the reciprocal effect, or eco-evolutionary feedback, is generally ignored by both evolutionary and ecological studies when evaluating host-parasite interactions. These assumptions possibly lead us to inaccurate understanding of the processes driving host-parasite communities and ecosystem dynamics in general. I aim to infer and predict coevolutionary outcomes in communities of several host and parasite species from host-parasite interaction networks and demographic histories. I will develop a unique combination of coevolutionary footprints in whole-genome sequences with dynamic network analysis (i.e. the network changes the distribution of interactions according to selected genotypes over time). I will use theoretical models and simulated data to link population genetics with interaction establishment and specificity at the ecological community level. Using the theoretical models, I will finally build statistical inference tools to infer and predict changes in real-world ecosystems based on empirical genome and network data. OUTCOME brings together studies on genomic coevolution (Prof Tellier, TUM), eco-evolutionary dynamics in empirical communities (Dr Möst, UIBK), and communities as complex networks (Dr Llopis-Belenguer). It will result in an enriching two-way transfer of knowledge and a complete development of the candidate as an independent researcher.

Keywords: community ecology genomes
EU TalentON Katowice 2024 - European Union Contest for early-career researchers (EU TalentON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Other ERA
Destination: Other ERA
Action type: Coordination and support actions
Countries involved: Poland
Call: European Union Contest for early-career researchers (HORIZON-WIDERA-2023-EU-CECR-IBA, 2023)
Start date: 2023-12-01
End date: 2024-11-30
Duration (months): 12.0
Total project cost (EUR): 499691.5
EU funding (EUR): 499691.5
Participants: 1
Project status: CLOSED

EU TalentON Katowice 2024 - European Union Contest for early-career researchers (EU TalentON) is the contest for early career researchers. A pilot took place for the first time in Leiden – European Capital of Science 2022. This event will challenge young talented researchers to find solutions contributing to the most pressing global issues. The four-day contest in 2024 will take place in Katowice in Poland. It will be one of the flag events during Katowice - European Capital of Science 2024 proceedings and will bring together more than 100 early career researchers from across EU and feature an extensive programme, co-created with academia, innovators and industry. Divided into small teams, talented early career researchers will receive the necessary tools (such as workshops, lectures, master classes, personal guidance and cultural experiences) to create innovative and marketable solutions to challenges, which are based on EU Missions. At the end of the event, each team will pitch their solution to a professional jury and the public. Winners will receive sponsored prizes. The EU TalentOn, directly contributes to the actions set out in the ERA Policy Agenda. Specifically, the contest helps bring science closer to citizens by inviting them to co-create solutions for our most pressing challenges.

Keywords: early career researchers,contest,competition,scientific solution,global issues,interdisciplinary cooperation
Privacy for Smart Speech Technology (PSST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,France,Portugal,Germany,Netherlands,Greece,Spain
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 4067942.4
EU funding (EUR): 4067942.4
Participants: 21
Project status: SIGNED

The unabated rise of smart speech technology, much of which is operated by entities outside of the European Union, has revolutionised consumer access to information and applications using the most convenient interface of all - the human voice. Recently, however, we have come to understand that smart speakers, smartwatches and other voice-operated devices may expose their users to privacy risks. Service operators and hackers alike can access not only spoken words but may also exploit sensitive non-lexical information contained within speech signals (such as health status) for nefarious purposes without the users’ knowledge or consent. However, innovative privacy-preserving smart speech technologies may mitigate these risks and help to create sustainable business models that are well aligned with EU regulations such as the GDPR and the forthcoming EU Artificial Intelligence (AI) Act. Therefore, the PSST joint doctoral training network will train a new cohort of researchers to develop these urgently-needed technologies using cutting-edge deep learning methods. PSST will focus on the suppression of speaker traits in speech signals, on enhancing usability in interactions between smart devices and cloud services, and on novel evaluation schemes that consider the most relevant threats. The PSST consortium is composed of world-leading research labs in speech processing, privacy and usability, and a larger number of innovative industrial partners. The joint academic-industrial partnership will establish a high-impact training programme that provides doctoral researchers with expertise in speech processing, machine learning and comprehensive knowledge of privacy threats and privacy-enhancing technologies. PSST partners and researchers will jointly create not only a unique, user-centred view of smart speech technologies but will also promote innovative business models for responsible and sustainable privacy-aware technologies in the EU.

Keywords: privacy in speech communication,speech processing,machine learning
Developing the world’s first quantum modem (QModem)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 3738125.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

We are in the midst of a quantum revolution. Quantum computers will bring unprecedented capabilities to scientists and engineers. Quantum communication networks now stretch for kilometres, enabling unhackable communication protocols. Remarkably, these technologies have evolved independently from one another. Quantum technologists are well aware of the immense potential of bringing communication and computing together. However, they have been unable to overcome a critical technical challenge: quantum computers and quantum channels operate at vastly different frequency regimes. We have solved this challenge. Our quantum modem is the first device in the world to implement high-fidelity quantum transduction and bridge the 100,000x frequency gap between the GHz-frequency typical of quantum processors and the THz telecom range. With our modems, quantum information is no longer confined to cryostats and can be routed via optical fibres across vast distances at room temperature.

Keywords: quantum modem,quantum computing,quantum internet