Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
QUantum-device Engineering with novel STates of matter (QUEST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-04-01
End date: 2018-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The goal of the proposed project is to employ novel states of matter for the development of new devices for quantum technologies, optoelectronics and ultrafast nanoelectronics. Speeding up and miniaturization of the existing electronics are approaching their physical limits. Novel states of mater are a rapidly growing field of science including quantum condensates and superconductors. One of the topics in the proposed project explores devices based on condensates of exciton-polaritons in semiconductors, representing both: ultrafast low-dissipation electronics due to their light-matter superfluid properties, as well as extremely nonlinear optics useful for quantum photonics. Another approach in the proposed project, which can provide a new direction in optoelectronic devices, is based on combining superconductors with semiconductors. The project takes advantage of the recent progress in high-temperature superconductors, which makes these technologies significantly more practical. Lately, a novel paradigm for finding new properties in the solid state has emerged - through the sudden change in topological invariants rather than breaking of symmetries. These topological phases of matter have been demonstrated to exist at the surface of some materials with strong spin-orbit coupling, revealing novel physical properties, including dissipationless spin currents with potential applications in spintronics and quantum technologies. A part of the proposed research focuses on devices based on proximity-induced high-temperature superconductivity in such topological insulators. This proximity effect has been predicted recently to produce the elusive Majorana fermion, which is of great interest for condensed-matter physics and quantum computation.

Keywords: quantum technology devices,optoelectronics,ultrafast,nanoelectronics,quantum condensate,high-tc superconductor,exciton-polariton,topological insulator,proximity,novel states of matter
Exploring pericyclic reactions for bioorthogonal imaging of biological processes with molecular precision (PERBIOIMAGE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-04-01
End date: 2018-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Bioorthogonal reactions have become essential tools for Chemical Biology and Drug Discovery. Despite recent advances in the development of bioorthogonal reactions, there still exists a need for reactions with improved kinetics and selectivities. Alkenes have been exploited in the context of site-specific protein modification and labelling, for example in cross-metathesis, photochemical 1,3-dipolar cycloaddition and tetrazine Diels-Alder cycloaddition strategies. Pericyclic reactions are a class of reactions where alkenes are suitable partners to achieve selectivity. These reactions are particularly attractive for applications in biological systems because their often-accelerated rate in polar media and their concerted mechanisms reduce undesired reactivity with biological nucleophiles and electrophiles. This project aims to 1) explore the reactivity of alkenes in benign aqueous conditions for site-specific ligand/protein labelling using a photoinduced [2+2] cycloaddition strategy, 2) site-specific incorporation of bioorthogonal group norbornadiene via genetic code expansion for directed site-specific cellular protein labeling, 3) the design and synthesis of ligands of ligands of oncogenic IL7R in T-cell acute lymphoblastic leukaemia (T-ALL) and 4) the use of a bioorthogonal approach for live cell imaging of oncogenic IL7R in T-ALL.

Keywords: bioorthogonal chemistry,peryciclic chemistry,bioimaging,photochemistry,cancer
MULTIFUNCTIONAL COMPOSITE AEROSTRUCTURES UTILISING CARBON NANOTUBE WEBS (MAGNUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The aim of this research is to create multifunctional lightweight composite aerostructures utilising the unique properties of recently-developed carbon nanotube webs (CNTWs), produced from directly spinnable CNT forests (highly aligned CNTs grown on a silicon substrate). These webs will be strategically introduced into laminated carbon-fibre material to mitigate the current limitations primarily associated with poor impact damage resistance and poor electrical conductivity for lightning strike protection. The piezoresistive properties of CNTWs will also be exploited for structural health monitoring of bonded joints and their thermal conductivity investigated for potential anti-icing applications. Remarkably the inclusion of CNTWs would add negligible weight to the overall composite structure but a number of challenges will need to be overcome for their effective utilisation. This research proposal details a body of work which will address these challenges. A successful outcome will deliver a disruptive technology in the design and construction of the next generation of composite aerostructures. It will yield a significant weight reduction in future airframes and potentially lower maintenance costs, which will contribute to the overall aims of the European Union to reduce the environmental impact of aviation. Some of the additional functionalities, arising from the use of CNTWs, will also be of interest to other transport sectors and the wind energy industry.

Keywords: composite materials,carbon nanotubes,multifunctional materials,fracture toughness,lightning strike protection,anti-icing,structural health monitoring,bonded repairs,fatigue,impact damage
Mechanisms of Mismatch repair inactivation and identification of genes suppressing mutations (IMMR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-04-01
End date: 2018-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The fidelity of DNA replication, and therefore the stability of the genome, relies on the DNA Mismatch repair (MMR) pathway, which recognizes DNA replication errors and promotes repair by an excision and re-synthesis mechanism. Mutations that inactivate MMR are associated to Lynch Syndrome, an early-onset cancer disorder characterized by accumulation of mutations at repetitive sequences or microsatellite instability (MSI). Interestingly, a significant number of tumors with MSI have not been correlated with MMR defects, suggesting that additional factors may influence MMR proficiency or DNA replication fidelity The current proposal aims to investigate alternative molecular mechanisms that result in MMR inactivation and to identify unrecognized genes that are essential for suppression of mutations. We will characterize a subset of Msh6 dominant mutations that abolishes MMR function by inactivating the partially redundant Msh2-Msh3 pathway. Furthermore, we will carry out a genetic screen to identify dominant mutations on the MMR-related genes: MSH3, MLH2 and MLH3 that result in MMR inactivation. Finally, we will carry out a genome-wide screen in budding yeast, to identify mutants that results in increased mutation rates. The human homologs of the identified yeast genes will be further characterized in human cell lines by knock-down experiments and in vivo mutator assays. This proposal is directed to achieve a better understanding of mechanisms preventing accumulation of mutations and will provide relevant information for diagnosis of cancer susceptibility syndromes.

Keywords: mismatch repair,mmr,mutations,dna repair,genome stability,cancer susceptibility
Summarisation and Sentiment Analysis for Evolving Multilingual Media Content (MEDIAGIST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

News aggregators gather thousands of news articles every day from across the world and cluster them into news stories comprising large numbers of articles about the same event. This is even augmented by the increasing amount of information in social media (e.g., Twitter, Facebook) where mass opinions about news events can be monitored. A promising way to reduce this bulk of highly redundant data is offered by the language technologies known as multi-document text summarisation and sentiment analysis. A major problem is that news articles are in many languages while current technology has mostly dealt with English, and the question of how current research can be applied in a heavily multilingual context has barely been addressed. Most multi-document summarisation research has focused on the news domain and MediaGist will do likewise in order to build on existing techniques and resources. However, summarising posts in social media, representing complementary and unbiased information, will be considered as well. Media professionals, however, will want to go beyond summaries from sources in one language and consider how news events are reported in other countries and from other perspectives. Identifying differences in opinion towards entities and events may provide some clues as the disagreements in reporting across languages. MediaGist will perform multilingual sentiment analysis and will thus make possible the generation of summaries that reveal these disagreements. The goal of MediaGist is to make significant advances in multilingual research so as to extract and present the GIST (the main content and opinions) of online multilingual news and the corresponding content in social media.

Keywords: automatic text summarisation,sentiment analysis,opinion mining,reputation management,opinion summarisation,news,social media,media monitoring,media analysis,multilingual processing
The role of gene regulatory elements in forebrain development and epilepsy (FB-REGULOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The human forebrain plays critical roles in cognition, motor function, and emotion. Impaired forebrain development and function are associated with neurodevelopmental disorders, including epilepsy. Early onset of epilepsy is a spectrum of disorders with strong genetic components that could be difficult to precisely diagnose and provide effective treatments. A major and underexplored cause of complex disorders could be mutations in gene regulatory elements. For example, disruption of these elements and subsequently the gene regulatory networks that are involved in brain development can lead to epilepsy subtypes such as infantile spasms (IS). However, the regulatory elements of forebrain expressed genes involved in IS are unknown. Using ChIP-Seq with enhancers and repressors marks, I will identify regulatory elements in the mouse embryonic day 16.5 (E16.5) developing forebrain. In order to determine which genes physically interact with these potential regulatory elements, I will carry out chromatin interaction analysis followed by paired-end tag sequencing (ChIA-PET) on E16.5 mouse forebrains. The interacted elements that are associated with IS genes will be tested for forebrain activity using zebrafish and mouse transgenic assays. Furthermore, the activity of positive enhancer sequences will be dissected using massively parallel reporter assays in a single nucleotide resolution to discover essential transcription factors required for forebrain activity. Altogether, these results will unravel a gene regulatory network of the developing forebrain, highlight functional IS-associated enhancers and determine the effect of mutations on their activity. This study will provide novel functional noncoding DNA sequences that play a role in epilepsy and other neurodevelopmental disorders.

Keywords: ggene regulation,gene regulatory elements,forebrain development,infantile spasms,epilepsy,enhancer,repressor,chromatin interactions,massively parallel reporter assay,chip-seq,chia-pet.
Assessing Temporally and Spatially Resolved PM2.5 and Air Temperature Exposures For Epidemiological Studies Using Satellite Based Methods (STRPM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-05-01
End date: 2018-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Exposure to PM2.5 has been associated with increased risk of myocardial infarction, reduced birth weights, cardiovascular and respiratory disease. Climate changes will lead to warmer air temperatures (Ta) and more extreme weather events,which are associated with increased morbidity and mortality in sensitive populations. Current epidemiological studies on the health effects of PM2.5 and Ta have many limitations.They are conducted using large geographical areas (potentially biasing the health effect risk estimates due to exposure measurement error) and are focused only in urban areas where the monitors are placed.There is also an increasing recognition that risk estimation must recognize that people are exposed to multiple risk factors simultaneously. Thus, there are huge methodological and knowledge gaps that must be filled.We need to identify the sources of heterogeneity in the short and long term exposure to air pollution and Ta effects across territories and across sub-populations as well as identify the risks associated with multi-threat exposure.To address this I aim to develop better statistical exposure assessment methods to handle the currently exposure datasets, which are misaligned in both time and space.Building on my previous work, I aim to develop and validate computationally efficient models that will allow me to more accurately estimate PM2.5 and Ta at a very high spatial (1×1 km) and temporal (daily) resolutions for Italy and France for 2000-2013. I will then make use of these generated PM2.5 and Ta estimations in a study assessing the effects of maternal exposure to PM2.5 and Ta on fetal growth. This study will dramatically advance environmental exposure assessment by producing high resolution spatio-temporaly resolved exposure models. These models will allow us to estimate both short and long term exposure effects in both urban and rural areas, reducing exposure measurement error and provide a sound epidemiological base for the magnitude of risks.

Keywords: air pollution,aerosol optical depth,epidemiology,pm2.5,exposure error,environmental health,air temperature
New Frontiers in Quantum Simulation (NEWFQS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Quantum Simulation has evolved into an active multidisciplinary field in physics, involving experimentalists and theorists working at the interface of Quantum Optics, Condensed Matter physics, and Quantum Information Science. In particular, an increasing experimental effort is focused in new technologies to scale up current setups, such as arrays of ion microtraps and arrays of coupled microwave cavities. A leap in complexity will be achieved in the fowollowing years, since new experiments will be able to enter into the true many-body regime. NewFQS (New Frontiers in Quantum Simulation) is a theoretical project that will explore the possibilities opened by emerging new technologies for analogical quantum simulation with many-body quantum optical systems. Our focus will be on trapped ion systems and ensembles of qubits coupled to optical or microwave cavities. In particular we will: (i) Study the idea of "ion-cluster" quantum simulation, in wich qubits are replaced by ensembles of ions, and its potential impact in the study of quantum glasses and lattice gauge theories. We will study the collective enhancement of atom-atom interactions in the ion-cluster scheme, and how it may allow us to design robust one and two-dimensional quantum simulations. (ii) Investigate dissipative quantum phase transitions that can be implemented with trapped ions and arrays of microwave cavities, in particular the quantum lattice analogs of the lasing phase transition. (iii) Design applications of many-body phases of quantum simulators for quantum metrology. The sensitivity of those systems near quantum phase transitions to external perturbations will be exploited as a basic principle for quantum sensing. We will design many-body atomic clocks with quantum simulators, in which entanglement and correlations in quantum systems are used to enhance the precision of interferometric measurements of time and frequencies.

Keywords: quantum optics and quantum information science. quantum simulation of many-body physics. quantum open systems. quantum metrology and sensing. numerical algorithms for quantum many-body problems.
Polycystic ovary syndrome (PCOS) and the gut microbiome (PCOS MICROBIOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-06-01
End date: 2018-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The polycystic ovary syndrome (PCOS) consists of anovulation, acne, hirsutism (resulting from hyperandrogenism), and reversed serum LH to FSH ratio and two hallmarks that include low grade inflammation and insulin resistance. These features place women with PCOS as a group of patients related to the metabolic syndrome. Baranova et al. even stated that "it seems appropriate to consider polycystic ovary syndrome as the ovarian manifestation of metabolic syndrome". Following the known evidence on the involvement of the microbiota in inducing low grade inflammation, the involvement in insulin resistance, how the gut microbiota and diet affect each other and a recent study on the favorable effect of diet even in lean PCOS patients, it is tempting to study gut microbiota primarily in lean PCOS patients, since this would neutralize the effect of obesity and the metabolic syndrome. It is possible that gut microbiota population, as the relevant "environment" of the patients, could bridge the gap and explains much of what has remained enigmatic in PCOS. This can also contribute significantly to treatment modalities, as interventions to alter gut microbial population profile have been shown to provide benefits in other situations.

Keywords: polycystic ovary syndrome (pcos),gut microbiota,germ free mice,diet,metabolic syndrome
Probing the role of sulfation (PROBING SULFATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The aim of the research proposed here is to investigate the role of sulfation in general, and more specifically in the context of chemokine signaling. For this purpose, tools will be developed that can be used to study and to interfere with sulfation. First of all, activity-based probes (ABPs) will be synthesized for both sulfotransferases and sulfatases by modifying known inhibitors with a (photo)reactive group. The resulting ABPs will be used to establish the activity of the different enzymes in the presence and absence of chemokines. Furthermore, a protein modification strategy will be developed that will allow the preparation of cells containing a well-defined sulfation pattern. The heterogeneous set of sulfated molecules that is presented by cells under normal conditions hampers the study of specific sulfation reactions in chemokine signaling. Affinity of chemokines for their cognate receptor is regulated by sulfation. The ability to introduce a homogeneous sulfation pattern that can be modified at will, should facilitate the study of sulfation’s importance in a systematic fashion. Although these tools will be used initially to investigate the role of sulfation in chemokine signaling, they may also be useful to study other processes that involve sulfation, like host-pathogen interactions, hormone-dependent cancers and lysosomal storage diseases

Keywords: sulfation,activity-based protein profiling,probes,chemical tools,protein labelling,chemokine signalling