Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of cellular mechanical stress in the pathogenesis of neurodegenerative disorders (NEUROMECH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Netherlands,United Kingdom,France,Luxembourg,Hungary,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 2880579.34
EU funding (EUR): 2647674.72
Participants: 14
Project status: SIGNED

NEUROMECH aims to establish a new generation of skilled, entrepreneurial, and innovative scientific leaders that will integrate the currently isolated fields of mechanobiology and neurodegenerative diseases. Mechanobiology explores the effects of physical forces on cell physiology. Evidence indicates that key mechanisms of neurodegeneration – cytoskeletal alterations, protein aggregation, protein phase transitions, DNA damage accumulation, and metabolic alterations – can be a consequence and cause of mechanical alterations. Mechanobiology may therefore be a unifying process in a broad spectrum of neurodegenerative diseases, which have rarely been approached from the mechanobiology prospective. NEUROMECH will bridge this gap and address the need for disease modifying therapies focusing on Alzheimer's and Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. NEUROMECH is an international and synergistic network of key scientific experts in mechanobiology and neurodegenerative diseases. Its ambitious research program ranges from atomic force microscopy to in vivo investigations using magnetic resonance imaging. The consortium includes industrial partners and a top European business school to provide training on managerial and strategic skills. These tools will allow Doctoral Candidates to fully understand and navigate both the complex landscape of neurodegenerative diseases research and the value chain of the very different organizations operating in this domain. Overall, NEUROMECH will provide Doctoral Candidates with multidisciplinary, intersectoral training that will enhance their career perspectives in academic and non-academic sectors.
Building Performance Digitalisation and Dynamic Logbooks for Future Value-Driven Services (CHRONICLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Spain,Greece,Italy,Denmark,Norway,Lithuania,Switzerland,Ireland
Call: Advanced energy performance assessment and certification (HORIZON-CL5-2021-D4-01, 2021)
Start date: 2022-07-01
End date: 2025-12-31
Duration (months): 42.0
Total project cost (EUR): 5995525.0
EU funding (EUR): 4950775.0
Participants: 19
Project status: SIGNED

CHRONICLE will deliver a holistic, life-cycle performance assessment framework and tool-suite for different building variants, supporting sustainable design, construction and/or efficient renovation and investment decision making. It will be methodologically integrate ongoing initiatives, like EPCs, Level(s), SRI, under the umbrella of the Digital Building Logbook concept. Performance will be assessed by means of well-defined KPIs, based on both static (by design) as well as dynamic information (sensor measurements) appropriately tailored to different types of use and building life-cycle phases (new or existing buildings under refurbishment). Continuous monitoring and analysis of the actual building performance over its lifetime, will be based on a powerful digital twin framework. The proposed data availability and accessibility within CHRONICLE will extend the limits of the EU energy related policies while the aggregated EPC advanced information will facilitate efficient energy planning. To this end, CHRONICLE will allow all stakeholders to realize in quantified terms the short- and long-term impact of the project activities, from policy to practice, and across the whole building life cycle. It will therefore promote evidence-based impact assessment practices to support policy coherence, design of smart penalties and reward schemes towards motivating energy consciousness, while also paying attention to the voice of market stakeholders (AECs, ESCOs, FMs) but also building owners and tenants/occupants, who are directly impacted by future regulatory decisions. CHRONICLE’s building performance assessment framework and tool-set will be demonstrated and validated in five pilot sites spanning the geographic diversity of Europe, namely in Spain, Ireland, Denmark, Greece and Switzerland.

Keywords: digital building logbook,whole life carbon,climate neutral buildings,building performance assessment,smart readiness indicator,energy performance certification
Decoding economy of the Leylatepe communities in the Chalcolithic Caucasus through functional analyses of ground stone tools (StoneCau)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 3
Project status: SIGNED

The project sheds light on socio-economic developments in the southern Caucasus during the Late Chalcolithic – a turning point on the pathway of human development, marked by the emergence of complex societies and early states within south-eastern Europe and south-western Asia. The study focuses on the nature and origins of the Leylatepe cultural phenomenon, which conveyed new trajectories in social differentiation, specialized craft industries, and interregional product exchange within the southern Caucasus and likely beyond, into the northern Caucasus, eastern Anatolia, and Syro-Mesopotamia. Despite that, the current state of research on the phenomenon is troubled by a narrow scope of reliable fieldwork data, lack of well-dated contexts, and publication scarcity. The research is based on the analysis of ground stone tools retrieved from four sites located in present-day Azerbaijan and Armenia: Alkhantepe, Leylatepe, Janavartepe, and Teghut, which emerged as Leylatepe settlements at the onset of the Late Chalcolithic period, in different environmental settings. Late prehistoric ground stone tools remain greatly underinvestigated, even though they were integral to various subsistence and craft-related activities of agro-pastoral villages in transition to social complexity. An integrative approach is employed, encompassing complementary (microwear, experimental, technological, contextual) methods of functional analyses of the tools. The high-resolution excavations of German Archaeological Institute (Berlin) and the Institute of Archaeology, Ethnography and Anthropology (Baku) at Leylatepe and Janavartepe grant an unprecedented insight into the phenomenon. The project is designed to tap into that potential and, consequently, it will be the first to yield insights into daily lives, food choices, and technological preferences of the Leylatepe phenomenon, illuminating socio-economic dynamics within the Caucasian communities and their interactions with ancient Mesopotamia.

Keywords: caucasus,chalcolithic,leylatepe,ground stone tools,functional analysis,microwear,use wear analysis,experimental archaeology
On-Antenna Multi-Analyte Biochemical Sensing (ASense) (Asense)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: CLOSED

Lab-on-chip (LOC) devices are useful for manipulating, analyzing, and interacting with small samples in a wide range of applications. Wireless LOC devices have been developed for remote and distributed analysis purposes where wired measurements are not feasible or cost-effective. The devices consist of a miniaturized array of biochemical sensors connected to a low-power radio transceiver. The current trend in wireless LOC devices is to miniaturize the sizes, lower the power consumption, and increase the processor capacity while driving down costs which are rapidly approaching their practical and theoretical limits. These raise the need for a new design to support the future sustainability of these devices to facilitate the current and upcoming massive deployments for use in various applications. Triggered by this, the project explores the revolutionary secondary use of the wireless antenna for multi-analyte active sensing purposes by deploying case-tailored sensing nanomaterials on the antenna surfaces current spots with each targeting a specific analyte using a Molecular Imprinting Polymer (MIP) layer grown above a highly conductive 2D transduction nanomaterial layer. The idea is to move the complexity from the wireless LOC to the computation of the gateway station, where signal processing and machine learning techniques are employed to remotely sense the targeted analytes. This is done by detecting changes on the radiation characteristics of the antenna caused by the applied sensing materials. The idea of using the antenna as a multi-analyte active sensor is an absolute novelty. If successful, the approach will have a huge contribution in reducing the hardware complexity of standard wireless LOC devices by at least 50% (no need to sensor integrated circuits, microcontrollers, and their associated power consumption), resulting in more than doubling their battery lifetime due to less power consumption, making large-scale mass deployment economically feasible.

Keywords: antenna design,sensor antennas,wireless biochemical sensors,lab on chip devices,nanomaterials,sensitive materials,wireless communications,signal processing,machine learning
Filling the Behavioral Gap in Disaster Risk Reduction and Climate Change Adaptation (FiBeGa)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1998950.0
EU funding (EUR): 1998950.0
Participants: 2
Project status: SIGNED

Do only foolish people drown and only compulsive gamblers suffer flood losses? Conventional wisdom is based on flawed underlying assumptions and the EU vision of a disaster- and climate-resilient society cannot be achieved by relying on “behaviour-blind” assessments and policy. Whilst the behaviour of individuals, businesses and public services before, during and after a crisis has a significant impact on damages, recovery and resilience, current assessments fail to include such critical factors because they are hardly understood. Floods and weather hazards are affecting 2bn people and exposure is expected to grow due to climate change. Despite trillions of public funds invested, current flood reduction and planning policies are failing to reduce risks and losses of lives. This is due to a mismatch between the rising application of risk, vulnerability and resilience assessments and the understanding of their empirical validity. The overreaching goal of this proposal is to move from “behaviour-blind” to “behaviour-aware” assessments, indicators and policies to save lives and public money. Lifting the current barriers to predicting and simulating risk perception and behaviour will create forefront knowledge and open new horizons. Social and technological changes have widened the gaps in our knowledge making new empirical research essential to refine or replace existing theories. This project will provide four demonstrators representative of the European and Mediterranean context, graded in size, wealth and exposure to reach general considerations: Paris, Barcelona, Bucharest and Algiers. It is aiming at cross-validation on floods and transferability to other emergencies (technological disasters, epidemics, terrorism, etc). It will launch a new line of research by providing “behaviour-aware” participatory assessments and indicators, spatially-explicit interactive short- and long-term simulation tools enabling decision-makers to refine their strategies and policies.

Keywords: perception behaviour resilience policy data science economy geography political science psychology sociology risk management
Medieval Placebo Effect: Hope and Belief in Healthcare in Christian Southern Europe 1100-1500 (MedPlaceboEffect)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1487500.0
EU funding (EUR): 1487500.0
Participants: 1
Project status: SIGNED

This project sets out to recover how hope and expectation for cure, belief, and trust configured late medieval medicine and the healing encounter. The therapeutic power of these sensibilities is recognized today by the modern clustering concept, placebo effect. This integrative project will identify the intellectual, social, and cultural forces in the medieval past that articulated and applied the idea that health may be improved by evoking certain sensibilities. In a triangular approach that examines ideas, practices, and organizing structures of healing activity, I analyze the medieval placebo effect as a paradigmatic attribute of the healing of the period. The project brings into dialogue current debates on the curative role of “symbolic aspects of a therapeutic intervention” with medieval perceptions of the soul’s impact on the body. By so doing it will shed new light on the salient engagement of medieval healing practices with hope, expectations, belief, and trust as critical elements of therapy. It will demonstrate the pervasiveness of placebo effect sensibilities. It will view the breadth of the engagement with the soul/mind as a formative aspect of healing theory and technique, and will show the dynamics between ideas, practices, institutions, and networks in procuring hope, belief, and trust in late medieval Southern European healing. By looking beyond the term to the components that link the phenomena, this historical project will enable the examination of a health system that is simultaneously alien to and part of the underlying legacy of European medicine and will offer a new path for thinking about these issues, essential for effective healthcare. MedPlaceboEffect will thus lay the groundwork for examining the ways these sensibilities are negotiated in the 21st century as healing practices face substantial challenges such as the growing distrust of medical services, and the increasing difficulty of overcoming placebos in pharmaceutical research.

Keywords: medieval medical theory and practice,medieval ritual and miracles,medieval emotions
Unveiling oceanic bacterivory through gene expression (BYGENEX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2498215.0
EU funding (EUR): 2498215.0
Participants: 1
Project status: SIGNED

Oceanic bacterivory is the process through which marine bacteria are grazed by microbial eukaryotes. It consumes a large fraction of bacterial production, transfers bacterial biomass to upper trophic levels, and completes the inorganic nutrient recycling needed for regenerated primary production. Global estimates indicate that ~15% of the Earth's primary production circulates through this process. Despite its central role in marine food webs, the identity of the dominant grazers is not well known, and in situ bacterivory rates are seldom measured as they require laborious techniques. Consequently, it is impossible to predict how oceanic bacterivory will react in light of the dramatic anthropogenic change we are facing. The aim of BYGENEX is to fill this gap and develop a quantitative approach to study oceanic bacterivory by using emerging omics-based tools that target marker genes for phagocytosis, the cellular mechanism behind bacterivory. We will first prepare an exhaustive collection of genomes from the main bacterivores in the global ocean. Then, we will identify highly expressed genes involved in phagocytosis in cultured and uncultured species across taxonomic lineages. We will perform in situ expression analysis of phagocytosis marker genes to quantify bacterivory rates of the community and of the dominant species, after calibration with direct activity measures. Finally, data from cruises will benchmark the present state of bacterivory in a range of oceanic regimes, and we will simulate bacterivory using a global ecosystem model to analyse ecosystem-wide effects of this process. BYGENEX will provide new tools to quantify oceanic bacterivory at unprecedented large scales and open the way to improve our current understanding of the structure and function of the microbial component and its role in the global marine system.

Keywords: bacterivory,ecosystem models,functional genes,gene expression,immunochemistry,microbial food webs,metatranscriptomics,phagocytosis,single cell genomics
Firms in (a) Greener Economy (FiGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 2
Project status: SIGNED

The proposed project addresses the growing importance of stringent environmental regulations as tools to mitigate greenhouse gas (GHG) emissions and improve environmental performance. While there is broad consensus on the need for decarbonization, the economic impact and effectiveness of these policies remain debated. Building on Nunez-Rocha & Silberberger (2021), this project will develop environmental stringency indicators using legal documents from FAOLEX and ECOLEX, focusing on Germany and France. These countries, with distinct energy approaches—Germany favoring renewables and France prioritizing nuclear energy—provide a unique basis for comparative analysis, both operating under EU regulations. The first objective (O1) is to create indicators of environmental regulation stringency for Germany and France. This will enable an in-depth assessment of how stricter regulations impact firms and will also evaluate the effectiveness of these regulations in enhancing environmental performance. The second objective (O2) explores the effect of environmental regulations on trade, focusing on how stricter policies impact imports, exports, and the comparative advantage of firms. The research will investigate the existence of a Pollution Haven Effect, where stricter regulations may push industries to relocate abroad. The third objective (O3) examines the impact of regulatory stringency on firm productivity, considering both short-term compliance costs and long-term innovation gains. This analysis will explore how different industries respond to regulations and whether innovation offsets potential productivity losses. The project aims to provide policy recommendations to design regulations that balance environmental protection with economic stability, enhancing environmental performance without displacing pollution or harming productivity.

Keywords: environmental regulation,environmental stringency,firm productivity,international trade,environmental quality,firms,pollution haven effect,pollution have hypothesis
SUSTAINCELL: Durable and Sustainable component supply chain for high performance fuel cells and electrolysers (SUSTAINCELL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Norway,France,Switzerland,Germany,Denmark,Spain,Finland
Call: Addressing the sustainability and criticality of electrolyser and fuel cell materials (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-01-01
End date: 2028-12-31
Duration (months): 72.0
Total project cost (EUR): 9993652.0
EU funding (EUR): 9993652.0
Participants: 11
Project status: SIGNED

The SUSTAINCELL project aims at supporting the European industry in the development of the next generation electrolyser and fuel cell technologies (both low and high temperature) by developing a sustainable European supply chain of materials, components and cells, significantly less reliant on critical raw materials (CRM), with lower environmental footprint and costs, and higher performance and durability than existing technologies. This will rely on scientific breakthrough innovations with the development of eco-design guidelines and environmentally friendly manufacturing routes applied for the production of new CRM-lean and/or CRM-free materials and architectures designed for maximising functionalities and durability, while decreasing CRM content per unit cell. The new flexible and scalable processing routes will exhibit higher productivity, as well as reduced utilities consumption and greenhouse gas emissions. The development of enhanced recovery and treatment processes for optimising both recovery and reuse of PGMs/CRMs and ionomers extracted from end-of-life stacks and production processes will furthermore reduce the reliance on import of materials. The novel solutions will be validated at cell level for all technologies using harmonized testing procedures. This ambitious work will be supported by the development and implementation life cycle thinking tools addressing environmental and economic dimensions to drive the research and development work using quantifiable sustainability criteria. The project is led by SINTEF and gathers CEA, CNRS, VTT, Forschungszentrum Juelich, TECNALIA, DTU, DLR, EPFL and HESSO world leading experts in the value chain of alkaline, proton exchange membrane, anion exchange membrane, solid oxide ion conducting and proton ceramic conducting electrolysers and fuel cells. The open innovation research will be actively communicated to European academia and industry to exploit the results of SUSTAINCELL for the benefits of the society.

Keywords: fuel cell,electrolysis,hydrogen production,power production,circularity,sustainability,environment,component value chain,critical raw materials