Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Geosphere INfrastructures for QUestions into Integrated REsearch (Geo-INQUIRE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,France,Norway,Spain,Netherlands,Portugal,Belgium,Greece,Iceland,Italy,Ireland,Poland,Switzerland,United Kingdom
Call: Research infrastructures services advancing frontier knowledge (HORIZON-INFRA-2021-SERV-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 13923475.77
EU funding (EUR): 13923475.77
Participants: 52
Project status: SIGNED

Geo-INQUIRE will provide and enhance access to selected key data, products, and services, enabling the dynamic processes within the geosphere to be monitored and modelled at new levels of spatial and temporal detail and precision. Geo-INQUIRE aims to overcome cross-domain barriers, especially the land-sea-atmosphere environments, and will exploit innovative data management techniques, modelling and simulations methods, developments in AI and big data, and extend existing data infrastructures to disseminate these resources to the wider scientific community, including the EOSC landscape. Geo-INQUIRE benefits from a unique partnership of 51 partners consisting of major national research institutes, universities, national geological surveys, and European consortia. Geo-INQUIRE will enhance and make interoperable the activities of the involved partners and conduct dedicated training programs for their optimal use. A portfolio of over 150 Virtual Access (VA) and Transnational Access (TA, both virtual and on-site) installations will be offered to the scientific community. While many such resources are already available at a high level of maturity, Geo-INQUIRE will ensure that they not only reach the highest level of scientific excellence through targeted actions on availability, quality, and spatial and temporal resolution, but also that they follow FAIR principles, adopt proper standards and open licenses, and aim at cross-disciplinary interoperability. Furthermore, the integration of different data, including new observables, products, and services will be optimized through TA activities via 6 test beds, which will also host workshops and summer schools dealing with the available resources. Ultimately, Geo-INQUIRE, with its enhanced data, product, and service portfolio, will enable the next generation of scientists to carry out leading-edge research addressing societal challenges from a multidisciplinary perspective, making intelligent use of these resources.

Keywords: geoscience data,services and data products,high performance computing,curiosity driven research,geohazard,georesources,virtual access,transnational access,fair,enhanced access provision
Sustainable Seafood Production (Bluegrove Welfare Shield)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Norway
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-07-01
End date: 2024-12-31
Duration (months): 30.0
Total project cost (EUR): 3567486.55
EU funding (EUR): 2497240.59
Participants: 1
Project status: CLOSED

Bluegrove Welfare Shield tackles an unresolved major issue in aquaculture: fish welfare; by introducing the most advanced salmon welfare monitoring and prediction solution. The system monitors fish behaviour 24/7 gathering data, which are combined with environmental models (e.g. water temp., oxygen & current speed, sunlight effects, weather conditions) and farming data (e.g. fish size & count, feeding area) to detect significant patterns that correlate with welfare issues. Obtained data is presented in a user-friendly dashboard (accessed both locally and remotely) providing live analysis of fish behaviour and appetite, fish welfare tracking, and alerts of potential conditions that could lead to welfare issues. Early detection of welfare issues enables farmers to take preventive actions to avoid an outbreak, and thus reducing mortality rates by 25% and improving fish growth up to 15%. It also provides advice on best practices, and benchmarking against the most productive fish cages.

Keywords: aquaculture,fish welfare,fish behaviour,hydroacoustic,artificial intelligence,salmon aquaculture
SoFtwarE DefinEd vehicle suppoRt And coordinaTion projEct (FEDERATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Coordination and support actions
Partnership: CHIPS (JU-JTI)
Countries involved: Austria,Germany,Türkiye,France,Netherlands,Finland,Lithuania
Call: Coordination of the European software-defined vehicle platform (CSA) (HORIZON-KDT-JU-2023-3-CSA-IA, 2023)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 1999996.25
EU funding (EUR): 1999996.25
Participants: 30
Project status: SIGNED

The automotive industry faces tremendous challenges in addressing decarbonization through electrification, developing future solutions for inclusive, safe and affordable mobility. Many of these changes require a radical re-thinking of existing development processes, with the share of software in modern mobility solutions continuously increasing. The rising importance of the software layer results in the so-called software-defined vehicle (SDV). Automotive software will be developed and adapted in continuous cycles. Therefore an abstraction from the underlying hardware needs to be implemented. As a result, the automotive industry is transitioning to an agile software development process. The dramatic increase of software and complexity, along with the advances of international competition in this domain, calls for an approach, in which non-differentiating software is developed jointly as open source. To address these challenges, the EU, together with industry, governments, and research institutions, have launched the European SDV Ecosystem. To turn this into reality, this proposal outlines the vision and activities for a Coordination and Support Action. FEDERATE (Software-Defined Vehicle Support and Coordination Project) aims to bring together all relevant stakeholders to accelerate the development of an SDV Ecosystem, to foster a vibrant European community and orchestrate the SDV R&D&I activities. The consortium of FEDERATE is formed by major European OEMs, automotive tiers, semiconductor companies, relevant industry associations and industrial SDV initiatives, including the Eclipse SDV WG, and supported by a scientific board. FEDERATE will work towards a common understanding on the vision of the SDV program and create an orchestrated advice for current and future projects in the SDV program. In addition, recommendations for future calls are prepared in alignment with a Roadmap and Joint Vision Document for accelerated SDV R&D&I, created as part of the CSA

Keywords: software defined vehicle sdv open source sdv ecosystem sdv hw platform,coordination support
UPSCALE OF AN INNOVATIVE AND SUSTAINABLE BIOMATERIAL FOR THE LEATHER INDUSTRY (BacLEATHER)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Turning animal skin into leather requires significant energy, and harmful chemicals, and releases substantial amounts of greenhouse gasses. Alternative synthetic leather is not an option since it is a highly polluting industry. We are using biotechnology to address the development of high-performance, animal-free, and more sustainable materials for the fashion, automotive, and home goods industries. We produce BacLEATHER, an eco-friendly material from microorganisms through an efficient and low-cost bio-production and proprietary process. Our technology provides solutions to the problems facing the leather industry, as our biomaterial has the same performances as the animal ones but are cleaner to produce (independent from animals, fossil-derived, and toxic chemicals), safer to wear, and ready to be used for manufacturers. BacLEATHER belongs to the nascent “next-gen materials industry” with a CAGR of 80% annually (2020-2026). Willingness to pay has already been confirmed with potential clients and we have established a collaboration with TEMPE, from GRUPO INDITEX (one of the most important brand footwear companies, owner of ZARA brand, among others) to prepare and validate the material for its market-fit within the footwear vertical. In 2022, Next-Gen Leather was funded by seed capital investors BeAble to exploit the technology previously developed by Patent Shoes,SL. Next step to develop this innovation will be to set up a pilot manufacturing plant so we are applying for Horizon Europe EIC Accelerator calls. But also we need to deploy our market positioning strategy to achieve the maximum visibility of our product and technology among all relevant stakeholders, clients and the public. In this sense, the support offered by Women TechEU Program will allow us that to design and execute a comprehensive communication and marketing strategy in a time-sensitive manner to target both potential B2B customers as well as future investors.

Keywords: bioprocessing technologies,bioreactors,industrial bioengineering,environmental and green technologies,novel materials,production technology,process engineering,sustainable fashion,bioproducts
A Paradigm Shift in Health Monitoring with Electrospun Enzymatic Neomaterials (WOUNDSENS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Germany,France
Call: EIC Pathfinder Challenge: Towards the Healthcare Continuum: technologies to support a radical shift from episodic to continuous healthcare (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 2934318.75
EU funding (EUR): 2934318.75
Participants: 4
Project status: SIGNED

Global healthcare associated with chronic non-healing wounds can be considered a main public health problem as affects up to 2% of the world population. A novel approach is needed mainly to support the quality of life of the people suffering from this silent epidemic and additionally, alleviate the impact in costs and resources for the healthcare system. Up to date, no smart bandages have made it to the real market and research state is still going on for a reliable and sensitive inspection method. The main goal of WOUNDSENS project is to lead the development of a novel generation of wearable biosensors with a synergy of technological breakthroughs in transversal fields of knowledge. Sensor elements, for the first time, will directly become a compatible part of the wound dressing material itself resulting in enhanced wearing comfort and operability. Accordingly, they will be integratable into manufacturers' existing standard processes (suturing, embroidery, roll-to-roll). Our proposal presents a parading shift in smart wound dressings constructed on novel hollow fibers with radial bio-signaling based on engineered novel enzymes. WOUNDSENS presents a leading-edge new technology with the design and development of innovative electrochemical materials with step forward advances in CONDUCTIVE MATERIAL, the development of electrospun neofibers and processes with leading edge methodologies on ELECTROSPINNING and the ENZYME ENGINEERING of a new family of detection biocatalysts (resurrected and extant enzymes) to secure a sensitive and reliable signal. WOUNDSENS proposal accepts the challenge of pushing forward the new technological platform to design a new concept in continuous wound control and monitoring improving the life of millions of people.

Keywords: wound dressing,electrospinning,carbon materials,graphene,enzyme engineering,directed evolution
Multi-Omics Brain Organoid dissection of Dravet Syndrome (MOBODS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Dravet Syndrome (DS) is one of the most severe developmental epileptic disorders in children, characterized by spontaneous recurrent seizures, developmental delay, and high risk of premature death. While approximately 80% of patients carry loss-of-function mutations in the SCN1A gene, clinical outcomes vary significantly, suggesting that other molecular and cellular factors influence disease manifestation. Although we know this mutation impairs inhibitory neuron function, it remains unclear 1) which other brain cell types are affected and 2) how these cells respond to the pathogenic environment by altering their genome regulation and cellular metabolism. MOBODS aims to map disrupted molecular pathways in DS at single-cell resolution, using a multidisciplinary approach that integrates brain organoid models, time-series multi-omics data, and computational methods. This research tackles three key challenges: identifying cell type-specific transcriptional changes, mapping gene regulatory network perturbations, and characterizing metabolic dysfunctions. By linking the genetic basis of DS with its clinical variability, these results can help develop in the long term more personalized therapies, particularly important as over 50% of DS patients are currently resistant to conventional treatments and require multiple anti-seizure medications. Furthermore, improved molecular characterization of DS symptoms can help reduce the stigma associated with epilepsy. Standardizing and validating the terminology used to describe symptoms can support patients in overcoming both interpersonal and institutional stigma, such as challenges in social interactions or discrimination in employment and insurance policies. Through this project, I will gain independence in experimental research, expertise in large-scale genetic studies, and leadership skills—all crucial for securing a tenure-track position in molecular and computational biology and effectively managing research resources.

Keywords: multi omics,single cell analysis,brain organoids
Candidatus Symbiodolus in Cryptocephalus beetles: unveiling the nature of this novel insect generalist symbiont (CUNNING)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Insects host various bacterial symbionts that can positively or negatively affect their fitness. While many symbionts coevolved within narrow host ranges, only a few generalist symbionts can colonize diverse insect taxa and tissues, with Wolbachia being the only well-studied example. The main aim of this project is to clarify the symbiotic nature of Symbiodolus (Enterobacterales), a newly discovered generalist symbiont infecting insects from six orders and colonizing various tissues. To investigate Symbiodolus' relationship with insects, the genus of phytophagous beetles Cryptocephalus (Coleoptera, Chrysomelidae), including both Symbiodolus-infected and uninfected species, will be used as a model. Specifically, the first project objective is to determine the prevalence and phylogenetic distribution of Symbiodolus within Cryptocephalus to define if it is a phylo-symbiont or if its association with the host is linked to other factors. It will be achieved by characterizing the bacteria hosted by different Cryptocephalus species and testing the phylogenetic signal of Symbiodolus presence/absence across the genus. The second objective is to determine Symbiodolus transmission mode by localizing it in Cryptocephalus body across developmental stages and within its excretions using fluorescence in situ hybridization. The third objective is to assess Symbiodolus impact on Cryptocephalus fitness by analyzing the genomes of strain/s infecting six Cryptocephalus species to determine the presence of genes related to host benefits, pathogenicity, and reproductive manipulation. Symbiosis manipulation experiments will also test the effects of selectively removing or introducing Symbiodolus on the host phenotype. Beyond clarifying Symbiodolus' symbiotic nature, this project will provide insights into the mechanisms governing the establishment and maintenance of associations between insects and generalist bacterial symbionts, as well as the evolutionary adaptations sustaining them.

Keywords: insect bacteria interactions,insect symbiosis,symbiont transmission mechanisms,bacterial genomics
Decoding the dynamics of NAD-Capped mRNAs: translational regulation of defense genes induced by plant intracellular immunity (DynaCapETI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Plant diseases critically impact global agriculture, economies, and society, underscoring the imperative for deeper insights into plant disease resistance and sustainable protective strategies. Recent pivotal findings from my host lab reveal a synergistic enhancement between plant cell-surface and intracellular immune systems. These findings suggest a complex system where intracellular immunity intensifies cell-surface immunity via sophisticated defense gene regulation. My central goal is to discern the intricate transcriptional and translational regulations of defense genes in plant immunity and to uncover how pathogenic effectors might potentially disrupt these processes during the dynamic dance of plant-microbe co-evolution. I will be addressing three objectives: 1) the crucial role of the NAD+ cap in defense gene dynamics; 2) the intricate translational dynamics of defense genes during immune responses; and 3) how pathogens cunningly alter mRNA decapping to weaken plant defenses. Leveraging advanced sequencing tools, I am poised to comprehensively map and profile defense gene regulation during effector-triggered immunity, known as intracellular immunity. This engages multiple disciplines including biochemistry, genetics, molecular biology, and bioinformatics. I aim to probe the roles of plant NAD-RNA, Nudix hydrolases, and Nudix effectors in defense gene modulation. The overarching outcome is to elucidate the intricate gene regulation framework of intracellular immunity, placing emphasis on the dual layers of plant immunity, and thereby redefining our grasp of pathogenic effector dynamics. This project will not only enrich my academic insights into plant immunity but will also refine my research skills, promise valuable networking and personal growth in project leadership, pave the way for publication opportunities, and significantly bolster my professional trajectory. Furthermore, it has great potential to make a meaningful contribution to global food security.

Keywords: plant innate immunity,effector triggered immunity eti,defense gene regulation,nad rna capping,mrna decapping,nudix hydrolases,nudix effectors,translational regulation,plant disease
ELectrOlysis of BIOmass (ELOBIO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: France,Spain,Germany,Netherlands,Estonia
Call: Novel routes to green hydrogen production (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4395570.63
EU funding (EUR): 4395570.38
Participants: 8
Project status: SIGNED

The ELOBIO consortium aims at advancing biomass electrolysis as a novel technological mean of green H2 production. ELOBIO will demonstrate that electrocatalytic oxidation of biomass-derived molecules offers the possibility to simultaneously reduce the energy cost and improve the chemical value of H2 production compared to the current water splitting technology. ELOBIO targets the development of low-temperature functional electrolysers capable of a large-scale production of H2 and value-added decarbonized chemicals, originating from the cellulosic biomass renewable exploitation. The project will design, build-up, test and improve a lab-scale prototype electrolysis cell at TRL4 involving a selective electrocatalytic cathode for the hydrogen evolution reaction and an electrocatalytic anode capable of selectively oxidizing biomass-derived compounds. Aldose-type sugars and furanic compounds were selected as model biomass for the validation of the concept. These molecules will be selectively converted to value-added chemicals which can be valorised in various sustainable chemical processes such as the production of biopolymers. Furthermore, several emerging technologies rely on electrolysis assisted with an additional renewable source of energy (ultrasound, magnetic field) or coupled with the concept of electrochemical promotion of catalysis will be explored to further enhance the energy efficiency of the green hydrogen electrolytic production. The technological advancements achieved in ELOBIO will scrupulously follow the EU recommendations on critical material avoidance, circularity and decarbonation objectives. A precise and detailed social life cycle will allow to pinpoint and reduce the sources of negative social, environmental and economic impacts of the proposed technology and thus improve its sustainability.

Keywords: biomass electrolysis,lignocellulose,decarbonised molecules,sono electrolysis,magneto electrolysis,over faradaic h2 production