Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bi-directional Force Communication on Cell-Matrix (BiFCCM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-10-13
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bi-directional mechanical exchange is crucial for many cell functions, is remains poorly understood, mostly since the majority of ECMs, both natural and synthetic, are difficult to control or lack biological relevance. A new synthetic polyisocyanide (PIC) gel is the first material that is an excellent mimic of the ECM (porous network architecture and nonlinear mechanics, including stiffening) and can independently tailor mechanical and biological properties. The gel is developed at Radboud University Nijmegen, where I finished my PhD. In this action, I want to study how forces from the cell or the ECM change the mechanical properties of the matrix and, more importantly, how this change affects biological functions. To this end, I will combine the unique, highly tunable PIC gels as synthetic ECM and study the matrix and cell behavior using advanced microscopic imaging techniques and spatial proteomics. Through PIC functionalization, I can tailor the size and number of focal adhesions (FAs), i.e. the protein complexes that link cells to the ECM. The forces generated by cells will be quantified both on cellular and single FA level by traction force microscope (TFM) and molecular tension sensor-based FRET. In addition, proteomic analysis will be performed to evaluate the effect of gels with different mechanical properties in the proteome. These results will have a high impact for understanding how cells interact with matrix through forces. Beyond my knowledge in biomaterials, I will gain new expertise in super-resolution microscope and mechanobiology at KU Leuven. This project highly matches the mission of the Marie Skłodowska-Curie Individual Fellowships to achieve two-way knowledge transfer and to promote my future career prospects.

Keywords: mechanobiology,cellular force,biomimetic hydrogels
Role of the SWI/SNF complex in the Androgen Receptor cistrome regulation (RegARcis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-31
End date: 2022-03-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The significance of epigenetic deregulation is a very hot topic in current prostate cancer (PC) research. New mutations have been identified in several epigenetic regulators known for their interaction with the AR. In fact, the role of chromatin remodeling factors facilitating enhancer-promoter cooperation in the formation of the AR transcriptional complex has long been demonstrated. Accordingly, the marked redistribution of AR binding sites (cistrome) during tumorigenesis is arguably the most recurrent genetic or epigenetic alterations in PC. Thus, this MCSA project aims at elucidating the role of the SWI/SNF chromatin-remodeling complex in the emergence of resistance to anti-AR signaling inhibitors. This is of utmost importance as resistance to AR signaling inhibition is arguably the principle hallmark of lethal prostate cancer. To this end, I aim at (i) investigating the SWI/SNF dependent chromatin accessibility and AR cistrome; and at (ii) assessing the actionability of SWI/SNF interacting partners in castration resistance prostate cancer (CRPC). In short, this MSCA proposal will help to define the repertoire of SWI/SNF coregulators in CRPC and to determine the extent of AR cistrome remodeling to envision new therapeutic strategies and help predict treatment response.

Keywords: prostate cancer,epigenetic deregulation,ar cistrome,snf complex,anti ar signaling inhibitors and castration resistance prostate cancer
Development of a potent dual GCS/GBA2 inhibitor as a best in class Gaucher therapeutic (Sphingolead)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-09-01
End date: 2018-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Gaucher disease (GD) is an autosomal recessive disorder caused by deficient activity of acid glucosylceramidase (GBA1). Most patients feature a non-neuronopathic (type 1) course of disease and are treated by either enzyme replacement therapy (ERT – administration of recombinant GBA1) or substrate reduction therapy (SRT – treatment with the iminosugar, Zavesca or the ceramide mimic, Eliglustat – inhibitors of glucosylceramide synthase (GCS)). These therapeutic agents do not prevent neurological symptoms in patients suffering from neuronopathic Gaucher forms (types 2/3) and there is thus an unmet medical need for these patients. Potent GCS inhibitors reduce glucosylceramide (GlcCer), the substrate of GBA and the storage material in Gaucher, and also higher glycosphingolipids including gangliosides and globosides, the causative storage materials in Tay-Sachs disease, GM1 gangliosidosis and Fabry disease. We have found a highly attractive lead, BiPheDNM 7 (Figure C below), which we plan to further develop towards a phase I/II clinical candidate. This proof of concept project will result in a packet comprising this lead molecule, accompanied by all the relevant data and tools to start phase I/II clinical development together with a pharmaceutical partner.

Keywords: glucosylceramide synthase,gaucher disease,gba1,gcs inhibitors
implementAtion anD OPeration of the gateway for healTh into BBMRI-ERIC (ADOPT BBMRI-ERIC)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Estonia,Italy,Germany,Italy,Malta,Cyprus,Switzerland,Norway,Türkiye,Sweden,Sweden,Switzerland,Belgium,Finland,Greece,Poland,Latvia,France,France,Czechia,Netherlands,Netherlands,United Kingdom
Call: Individual implementation and operation of ESFRI projects (H2020-INFRADEV-1-2015-1, 2015)
Start date: 2015-10-01
End date: 2019-03-31
Duration (months): 42.0
Total project cost (EUR): 4949448.91
EU funding (EUR): 4949448.899999999
Participants: 28
Project status: CLOSED

BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical research. The ADOPT BBMRI-ERIC proposal aims at boosting and accelerating implementation of BBMRI-ERIC and its services. Its main deliverables are designed to complete or launch the construction of key Common Services of the Research Infrastructure as required for ESFRI-projects "under implementation", reflecting the targets of the European Research Area (ERA). One of the challenges in the post-genomic era is the research on common complex diseases, such as cancer, diabetes and Alzheimer’s disease. Revealing these diseases will depend critically on the study of human biological samples and data from large numbers of patients and healthy individuals. The EU’s ageing population is will result in an increase in many of those diseases and consequently an increased healthcare expenditure for senior citizens. BBMRI-ERIC is a specific European asset having become a fundamental component in addressing the ongoing and future requirements particularly of Europe's health service frameworks, including competitiveness and innovativeness of health-related industries. Its implementation is essential for the understanding of the diversity of human diseases, biological samples and corresponding data, which are required for the development of any new drug or diagnostic assay and are, therefore, critical for the advancement in health research, ultimately leading to personalised medicine. BBMRI-ERIC will provide a gateway access to the collections of the European research community, expertise and services building on the outcome of ADOPT BBMRI-ERIC.

Keywords: biobank collection biospecimen data biomolecular analyses it ethics
Poetry Standardization and Linked Open Data (POSTDATA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Spain
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1131413.0
EU funding (EUR): 1131413.0
Participants: 2
Project status: CLOSED

This project aims at bridging the digital gap among traditional cultural assets and the growing world of data. It is focused on poetry analysis, classification and publication, applying Digital Humanities methods of academic analysis -such as XML-TEI encoding- in order to look for standardization. Interoperability problems between the different poetry collections are solved by using semantic web technologies to link and publish literary datasets in a structured way in the linked data cloud. The advantages of making poetry available online as machine-readable linked data are threefold: first, the academic community will have an accessible digital platform to work with poetic corpora and to contribute to its enrichment with their own texts; second, this way of encoding and standardizing poetic information will be a guarantee of preservation for poems published only in old books or even transmitted orally, as texts will be digitized and stored as XML files; third: datasets and corpora will be available and open access to be used by the community for other purposes, such as education, cultural diffusion or entertainment. To accomplish such a ground-breaking approach, I have a hybrid profile, combining a strong philological background, specialized in poetry and metrics, with a deep knowledge of Digital Humanities proven by my leadership and experience in interdisciplinary projects. Since 2011, I am the Principal Investigator of the first Digital Repertoire of Medieval Spanish Poetry (ReMetCa), an innovative project that combines traditional metrical analysis with digital text encoding, and since 2014 I am the Academic Director of LINHD, The Digital Humanities Innovation Lab created at UNED as a research interdisciplinary centre.

Keywords: digital humanities,linked open data,text encoding initiative,metrics,poetry,semantic web,interoperability,standardization
A cutting edge transcription process and technology revolutionizing the transcription industry. (Verbatizer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Israel
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In today’s business environment, an endless string of meetings, interviews, conferences and seminars are being conducted. In this scenario, deaf people often lack access to information, being this considered as indirect discrimination. Companies shall provide reasonable accommodation for deaf and hard of hearing people since they are at high risk of becoming unemployed and remaining unemployed, drifting into long term unemployment. Moreover, it is a fact that the majority (56%) of deaf or hard of hearing employees have experienced discrimination during their career, leading to one out of four deaf people leaving a job because of a difficult environment. Verbatizer makes transcription services easier and more profitable. With an overall accuracy of 95%, it is the most accurate technology in the transcription industry. Verbatizer guarantees the fastest turnaround time at any volume and a highly experienced team of transcribers, which make possible the most competitive price per value in transcription market. The breakthrough behind Verbatizer are its processing modules, able to discriminate between different languages and speakers, improve recognition sensitivity regardless the environmental noise and recognise the topic of the audio for improved accuracy. To date, we have raised €650K from the Israeli OCS and €3.4M from top tier Venture Capitals and private investors, of which €1.92M have been invested into the development of our ASR engine and ensure its robustness and efficacy. Within the overall project, we intend to finalise software engineering and conduct a multi-customer pilot trial within Europe. Current IP portfolio will be expanded to EU. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of Verbatizer and its market uptake.

Keywords: transcription,language,speakers,translation,machine learning
ECCSEL ERIC – accelerating user access, growing the membership and positioning internationally to ensure long-term sustainability (ECCSELERATE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Italy,Norway,Norway,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 4877668.41
EU funding (EUR): 3529568.75
Participants: 21
Project status: SIGNED

ECCSEL ERIC was established on 1 June 2017 and is on track to gain recognition as a world-class research infrastructure (RI) based upon leading European Carbon Capture and Storage (CCS) institutions and knowledge centres. It is now an approved European RI Consortium legal entity with its statutory seat in Trondheim, Norway. Under the financial support of the European Union, coordinated by the Norwegian University of Science and Technology (NTNU), ECCSEL has been implemented by a consortium of leading European CCS research institutes over two previous preparatory phases, and two years of initial phase operations supported by the ECCSEL Implementation Phase INFRADEV3 project (GA 675206, 2015-2017). ECCSELERATE builds on these solid foundations. ECCSEL is currently in its early operational phase as an ERIC, and needs to ramp-up to an advanced stage of operation. Based on recommendations from EC stakeholders and the ECCSEL ERIC General Assembly, ECCSELERATE will focus on: •increasing use and ensuring the long-term sustainable operation of ECCSEL ERIC RI; •cost-effective sharing and use of ECCSEL ERIC RI by industry and SMEs; •developing marketing, access and service models for industry and SMEs; •increasing international collaboration and visibility; •exploring the scope for extension to CO2 utilisation technology developments and potential synergies, thereby extending ECCSEL ERIC activities from CCS to CCUS; •expanding ECCSEL ERIC membership and developing its national nodes; and •increasing ECCSEL ERIC’s involvement with ongoing industrial CCS projects. This will enable ECCSEL ERIC to play its key role as specified in the SET-Plan TWG9 CCS and CCU Implementation Plan: ’a world-class research infrastructure facilitating ambitious R&D activities, European industrial initiatives, and education of specialists for the new CCUS industry.’

Keywords: co2 capture,transport,storage,utilisation,ccus,research infrastructure,eric,growth,long term,funding,access,accelerate,increased use,promote,expand,climate change
fRamework for Actual Cooperation on Energy on Sites and Parks (R-ACES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Italy,Italy,Belgium,Belgium,France,Netherlands,Denmark,Denmark,Denmark
Call: Business case for industrial waste heat/cold recovery (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-06-01
End date: 2023-03-31
Duration (months): 34.0
Total project cost (EUR): 1980376.25
EU funding (EUR): 1980376.25
Participants: 12
Project status: SIGNED

R-Aces means a step-change in the contribution of European Industry to the climate targets of the EU. The sector after all represents 25% of all energy demand – and 50% of all cooling and heating - on the continent; yet only 16% comes from renewables. By focusing on collective measures and clustering, the efficiency of industry can be drastically increased. The focus of R-Aces therefore is to turn high-potential, high-impact industrial clusters into Ecoregions that achieve at least a 10% reduction in emissions. An Ecoregion is an area where energy, material and information exchanges occur between various companies and actors to reduce waste and energy/material consumption. Each region is centered on an (eco-)industrial park or (eco-)business park, linked to its surroundings by a 4th/5th generation district heating/cooling network. The consortium sees this project as a capping stone, condensing the knowledge and experience gathered throughout H2020 into a set of three focused tools embedded in selected support actions. The tools consist of an assessment tool; legal decision support for joint contracts; and a smart energy management platform for clusters. The support actions are built around peer-to-peer learning, more formal coursework and serious games. Together they enable a cluster to really become an EcoRegion and set up meaningful energy collaboration. The entire package of tools and support is aimed at the high-potential clusters identified in the European Thermal Roadmap. It will be validated in three of them (all are part of the consortium); actively deployed in another seven; and disseminated to ninety of them. In addition, the tools and support methodology will be made available to third parties in a sustainable way after the end of this two-year project. The project consortium consists of the entire value chain needed for energy collaboration – suppliers, ESCO, cluster managers, support – and represents many years of proven experience in this field.

Keywords: industrial symbiosis,heat exchange,eco region
Applying state of the art smart sensor technology and Structure from Motion (SfM) photogrammetry for quantification of large wood (LW) movement processes and accumulation assessment in fluvial systems (SmartWood_3D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Large wood (LW) plays an important role in fluvial systems as it moderates stream power, regulates sediment transport and provides habitat for fish and other living organisms. Besides the beneficial effects of a balanced wood budget in rivers, challenges arise for abundant quantities of accessible LW. Large quantities of wood show negative effects on stream ecology, river-crossing infrastructure and flood mitigation. The sudden and disastrous occurrence of LW during floods regularly affects communities and stream systems all over the world. Due to a lack of applicable methodologies in LW research little is known about transport dynamics of wood in rivers to date. In order to expand the current understanding of flow-sediment-wood interaction processes, especially at higher flow rates, specific and profound research is required. This project aims to utilise state of the art technologies for the application in nature sciences. Nine-degree of freedom (9-DoF) smart sensors are implanted into wood logs ‘SmartWood’, to capture complex movement processes in-situ. Furthermore, Structure from Motion photogrammetry is applied for the generation of 3D LW accumulation models, on a basis of 2D images, for precise volume, porosity and surface texture evaluation. The innovative methodologies allow for novel insights into LW movement behaviour and for quantification of wood deposits, which are often obstructing and diverting the flow. An improved understanding of LW movement processes is essential to better predict arising impacts on channel morphology, river-crossing infrastructure and environment. Gained results will contribute in a more reliable risk assessment for wood prone stream systems, advanced river and forestry management strategies under consideration of LW conveyance and filtering of critical key-logs, and to realize a concept that allows wood in rivers, as a natural and environmentally important element, consistent with modern land use and infrastructure.

Keywords: large wood lw research,quantification of lw movement and accumulation processes,lw jam assessment,structure from motion sfm photogrammetry,nine degree of freedom 9 dof smart sensors