Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FGF1: a novel metabolic regulator involved in insulin sensitization and glycemic control (FGF1T2D)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-08-01
End date: 2015-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Type 2 diabetes (T2D) and obesity are leading causes of mortality and are associated with the Western lifestyle, which is characterized by excessive nutritional intake and lack of exercise. A central player in the pathophysiology of these diseases is the nuclear hormone receptor (NHR) PPARγ, a lipid sensor and master regulator of adipogenesis. PPARγ is also the molecular target for the Thiazolidinedione (TZD)-class of insulin sensitizers, which command a large share of the current oral anti-diabetic drug market. Despite their efficacy in glycemic control, TZDs are associated with various adverse side effects, including weight gain, edema, and liver and cardiovascular toxicity, which limits their clinical use. During my postdoctoral research in the laboratory of dr Ronald M. Evans, at The Salk Institute, I have developed a novel screening tool for the functional analysis of complex transcriptional pathways. Using this technology, we have identified Fibroblast Growth Factor 1 (FGF1) as a novel target of PPARγ. In experiments with FGF1 knockout mice, we further demonstrated that these mice develop high-fat diet induced insulin resistance and hepatic steatosis, underscoring its significance in the development of T2DM. The studies proposed here aim to investigate the pharmacologic effects of FGF1 on energy metabolism and the development of T2D. This novel pathway defines a previously unrecognized mechanism for the insulin sensititizing actions of TZDs. Therapeutic targeting of FGF1 could serve as an improved strategy for the treatment of T2D, eliminating some of the adverse effects of TZDs that are mediated through direct activation of PPARγ.

Keywords: type 2 diabetes,insulin resistance,ppargamma,fibroblast growth factors
Single-molecule junction capabilities to map the electron pathways in redox bio-molecular architectures (SINGLE-BIOET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2012-03-09
End date: 2016-03-08
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposal presents a novel methodology to explore the mechanisms of different electron pathways in redox bio-molecular architectures at the single-molecule level. Single-molecule contacts have been shown to be experimentally realizable at room temperature. Scanning Probe Microscopies are the most employed techniques for creating contacts due to the high spatial resolution. A huge variety of molecular systems has been already explored bringing a more robust understanding of the critical parameters required to build and measure charge transport through single-molecule devices; stable molecule-electrode chemical binding, univocal detection of a single-molecule contact formation or the elucidation of the effect on charge transport by different chemical groups. Single-molecule junctions with more complex bio-molecular systems are less explored but their feasibility has been already demonstrated on well-know structures like DNA or alpha-helices. Sulfur-content chemical groups are targeted in these systems to allow long-lived electrical contacts to the metal electrodes. Here we propose to use the above methodologies to achieve a complete picture of the electron pathways on an individual bio-molecular redox structure. Different electron pathways can be selected by forming single-molecule junctions at different positions of the outer shell of the protein structure. Site-directed mutagenesis can be used for creating the specific sites. A step further in this project will be to explore the dominant parameters involved in the sequential-step hopping electron transfer (ET). Such a study will provide clues for the understanding of the structural effects on the long-range ET in living organisms. This proposal assures a novel pioneering research particularly designed for the present host institution specialized in Biochemistry to be led by an expert researcher in the field of Molecular Electronics.

Keywords: single-molecule junctions,single-bio-molecule junction,electron transfer,et on bio-molecules,metalloproteins,hopping et
Unraveling the circuits of locomotion with opto-genetic manipulation of neuronal activity in awake behaving animals (OPTO-LOCO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-11-01
End date: 2016-05-02
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. The manipulation of electrical activity and cell signaling in specific neuron type using light gated receptors enables us today to dissect the specific neuronal circuits forming the CPGs, and understand the dynamic role of sensory inputs in awake behaving animals. During my work in UC Berkeley, I developed the use of light gated receptors in vivo (Szobota 2007, Pautot 2008 and Wyart 2009). This novel approach enables us to test directly the role of specific pattern of activity in genetically identified neurons for shaping the complex locomotor behaviors. Using a combination of targeted gene expression and optical tools for monitoring and manipulating neuronal activity (“optogenetics”) in awake behaving animals, we have revealed the role of mysterious cells present at the interface between the spinal cord and the central canal: the cerebrospinal fluid (CSF) contacting neurons. I demonstrated that during early development in low vertebrates these cells provide the positive drive to the spinal central pattern generators for spontaneous locomotion (Wyart et al 2009). My future plan focuses on investigating further the circuits of locomotion in the healthy and severed spinal cord. My project consists in three distinct aims: Aim 1. To examine the chemo- and mechano-sensory functions of spinal CSF-contacting neurons Aim 2. To elucidate the role of dynamic sensory feedback for triggering transitions during locomotion Aim 3. To improve recovery of function after spinal cord injury using optogenetics

Keywords: natural sciences,technological sciences
European integration process in the new regional and global settings (EUINTEGRATIO)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Socio-economic sciences and Humanities
Action type: Coordination and support actions
Countries involved: Poland
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2011-01-19
End date: 2012-01-18
Duration (months): 12.0
Total project cost (EUR): 199616.0
EU funding (EUR): 149618.0
Participants: 1
Project status: CLOSED

The core of the project is planned conference that will be organized on the issue of the European Integration process in the new regional and global settings with a focus on three main policy areas: social reforms and social cohesion, the new financial perspective, the single market with special attention to such areas as the capital movement, financial services and the labor mobility within the single market. Thus the conference will attempt to highlight the contribution of an open European Research Area to effectively address these challenges. This project is aimed at activating the academic community and policy makers in Poland as well as in other EU Member States to conduct the important role in policy making in executing the Strategy 2020 for Europe. The project will result in a systematic approach to integration processes, what means an analysis of the presence and future challenges. It is unavoidable to embedded the Polish Presidency within the EU strategy “Europe 2020”. The project will be composed on three main phases: I.The establishment of the Thematic Working Groups (4) which will be responsible for preparing the key topics of the Presidency conference in cooperation with the International Advisory Board and the Project Steering Committee which will act as the Conference Programme Committee. II.The second phase will be based on two types of activities: - organization of the Thematic Working Groups meetings - organization of the two-day International Presidency Conference which will be based on the input and recommendations generated by Thematic Working Groups. III.The follow up of the project is to create post-conference proceedings and report. It is intended to issue the final report that will present the forward-looking perspective recommendations of the integration process within the EU for policy makers and will present the research needed to be conducted in different spheres of these process

Keywords: integration process,polsh presidency,crisis,policy makers,social challenges,financial system banking system,energy,environment,europe 2020 strategy,security
Turboprop and Propfan-Equipped Aircraft Noise Emission Model (FLIGHT-NOISE-II)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-12-01
End date: 2014-09-30
Duration (months): 34.0
Total project cost (EUR): 348870.0
EU funding (EUR): 261652.0
Participants: 1
Project status: CLOSED

This project aims at delivering a multi-disciplinary computer program capable of simulating the noise emission and propagation of modern airplanes powered by turboshaft engines coupled to conventional propellers or advanced propellers (propfan). This document describes existing computer programs (FLIGHT and FLIGHT-NOISE) that comply substantially with the requirements of the Call for Proposals (Call). More specifically, the proposal has the following objectives: • To produce state-of-the-art aircraft noise, emissions & propagation software. • To validate the software with clear benchmark test cases. • To provide support technical beyond the duration of the project. The main project deliverables are: 1. The Software, including an “Airframe Module”, a “Propulsion Module” and “Noise Propagation Module”. 2. Database of turboprop engine performance (flight envelopes). 3. Validated prediction tools. 4. Software documentation, including user’s manuals (20 deliverables). The project is expected to deliver benefits in other areas, such as: 1. Multi-disciplinary approach to aircraft noise and flight operations. 2. Flexibility in predicting sources of noise, noise perception, noise propagation. 3. Engineering advancements in the areas of advanced propeller noise. 4. Prediction of combustion emissions. This project is proposed to compensate for the imbalance between the requirements of the aviation industry and the technology currently implemented in Aircraft Flight and Noise Prediction programs. In particular, noise propagation tools are currently unavailable to the industry.

Keywords: aircraft noise,aircraft operations,environmental emissions,propellers,advanced propellers (propfans),turboshaft engines,software engineering,flight performance
Coordination action in support of the implementation of a Joint Programming Initiative (JPI) on Cultural Heritage and Global Change : a new challenge for Europe (JHEP)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Environmental technologies
Action type: Coordination and support actions
Countries involved: Italy,Netherlands,Cyprus,Türkiye,France,Ireland,Belgium,Romania,Slovenia,Spain,United Kingdom,Poland
Call:  (FP7-JPROG-2011-RTD, 2011)
Start date: 2011-10-01
End date: 2015-03-31
Duration (months): 42.0
Total project cost (EUR): 2242800.0
EU funding (EUR): 1999830.0
Participants: 15
Project status: CLOSED

Europe’s cultural heritage is the world’s most diverse and rich patrimony attracting millions of visitors every year to monuments, historical city centres, archaeological sites and museums. Moreover, heritage is an important component of individual and collective identity. In both its tangible, intangible and digital forms, it contributes to the cohesion of the European Union and plays a fundamental role in European integration by creating relations among citizens. The JPI on Cultural Heritage and Global Change: a new Challenge for Europe has recently defined a common vision which needs to be translated into a Strategic Research Agenda. A CA is needed to allow Member States and Associated Countries to implement the Joint Programming for jointly providing areas where public research programmes can respond to major societal challenges. This, in turn, will need to be implemented under an adequate management structure, with associated activities to both disseminate the objectives and initial achievements, and provide an evaluation framework for addressing its impact. JHEP intends to structure and support this JPI to implement the action programme for the area of research on cultural heritage in a changing world. The main objectives of JHEP are therefore: - Providing necessary administrative and logistical support to the meetings of the Governing Board, Executive Board, Scientific Committee and Advisory Board required for the development and implementation of the SRA and Action Programme. ‐ definition of strategic and scientific priorities to develop the scientific research agenda ‐ implementation of joint and coordinated research activities - extension of the partnership, cooperation at global levels and with international and NG organizations, ‐ evaluation and monitoring of the joint activities, - engagement of stakeholders through a communication plan to ensure the translation of research outputs into practice and policy.

Keywords: cultural heritage,global change,cultural identity,intangibile,tangibile and digital heritage,societal challenge,protection. security,climate change economic environmental and social impact
Time-resolving electron dynamics in molecules by time-dependent many-electron theory (TDMET)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Denmark
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-12-01
End date: 2016-11-30
Duration (months): 60.0
Total project cost (EUR): 1330305.0
EU funding (EUR): 1330305.0
Participants: 1
Project status: CLOSED

The interaction of atoms and molecules with new light sources such as attosecond and free-electron lasers is under strong current experimental investigation. Within the next few years the interest will shift from relatively simple systems with a few atoms and electrons to bigger systems with many atoms and may electrons. The aims will be to study time-resolved dynamics and chemical reactions on the natural timescales for these processes. To fulfill this ambitious goal, there will be a strong need for the development of new theory to guide the experiments and to analyze and understand the results. Currently there is no satisfactory theory in this research area that can treat more than the nonperturbative response of a single electron in a model potential. It is the purpose of the present project to develop such theory.

Keywords: attoscience,free-electron laser,time-resolved dynamics,molecular movie
Developing predictors of the health benefits of exercise for individuals (META-PREDICT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Sweden,Denmark,United Kingdom,Denmark,Finland,Spain,United States,United Kingdom,Canada,United Kingdom
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-12-01
End date: 2016-05-31
Duration (months): 54.0
Total project cost (EUR): 7928824.85
EU funding (EUR): 5998406.0
Participants: 12
Project status: CLOSED

Physical activity is a powerful lifestyle factor that on average reduces risk for development of diabetes and cardiovascular disease. Nevertheless, we have demonstrated that following supervised endurance exercise training, 20% of subjects show no change in fitness and 30% demonstrate no improvement in insulin sensitivity or worse-still an adverse response. Our concept is that by using molecular profiling of blood/muscle samples we will develop personalised lifestyle intervention tools. Further, revealing the biological basis for a variable metabolic or cardiovascular response to exercise will enable us to propose new targets and biomarkers for drug discovery efforts directly in humans. Using our established OMICS approaches (RNA, DNA and Metabo-) we will generate classifiers that predict the responses to exercise-therapy (fitness and insulin sensitivity). Classifier generation is a statistical strategy for diagnosis or prognosis. Critically, we have a large human tissue biobank, including subjects with insulin-resistance; young to elderly males and females, as well as twins. Our SME partners have significant intellectual property and capacity in the field of bio-prediction, with a proven track-record of collaboration with the team and product development. We will add to the diversity of our biobank by carrying-out an exercise intervention study using a novel time-efficient strategy that we have recently proven to be effective in reducing insulin resistance in sedentary young people and in middle aged obese subjects. A time-efficient protocol is a critical as lack-of-time is a key reason for not maintaining physical activity levels. Finally, we have a novel out-bred rodent model that replicates high and low exercise training responses and we will establish its suitability for future drug screening purposes. Because of these substantial pre-existing resources we believe that our project has a very high probability of delivering on its goals of improving the healthcare of European citizens

Keywords: personalised medicine,insulin resistance,cardiovascular fitness,life-style,metabolomics,genomics,transcriptomics,molecular classification,aerobic and resistance exercise training
Single-atom-resolved detection and manipulation of strongly correlated fermions in an optical lattice (FERMILATT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2016-09-30
Duration (months): 60.0
Total project cost (EUR): 1392800.0
EU funding (EUR): 1392800.0
Participants: 1
Project status: CLOSED

I propose to realize single-atom- and spin-resolved in-situ imaging of strongly correlated fermions in an optical lattice. Whereas very recently strongly correlated bosonic systems could be imaged in an optical lattice at the single atom level, an experimental proof of single-site-resolved detection of fermions is still lacking. My project will allow to fully exploit the potential of ultracold atoms as a quantum simulator, especially for the Fermi-Hubbard model, which is a key model in condensed matter physics. Gaining access to the in-trap atom distribution of the fermionic 40-potassium with single-atom and single-site resolution will allow for a new generation of experiments in the field. Direct observation of individual atoms and analysis of their quantum states and their spatial order in the lattice, including individual defects, are then possible. I will use this novel detection method to characterize, e.g., temperature or entropy distribution of the quantum phases such as fermionic Mott insulators, Band insulators or metallic phases. Together with the possibility of local spin manipulations, I will investigate the effect of local perturbations on the system by spatially resolving the ensuing dynamical in-trap evolution. In this way, propagation and healing of artificially created defects can be studied. Local scale density modulations such as Friedel and Wigner oscillations of one-dimensional systems with hard boundaries will become observable. The local manipulation of the trapped atoms will be the key to implement novel cooling schemes that can remove regions of high entropy from the system. In this way much colder temperatures can be realized, where antiferromagnetic ordering is setting in. In a harmonic trap, these magnetically ordered phases are predicted to form ring-like structures, which can be ideally characterized by my novel spin-sensitive in-situ imaging techniques.

Keywords: quantum gases,optical lattices,quantum simulation
Implant Disposable Antibacterial Coating (I.D.A.C.): a Novel Approach to Implant-Related Infections in Orthopaedics and Trauma Surgery. (I.D.A.C.)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: France,Italy,Greece,Netherlands,Germany,Belgium,Belgium,Finland
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2015-06-30
Duration (months): 42.0
Total project cost (EUR): 4029693.33
EU funding (EUR): 3000000.0
Participants: 12
Project status: CLOSED

With a share of 38%, orthopaedic and traumatology (O&T) are the worldwide leading markets of implanted biomaterials, involving millions of new patients each year at an increasing trend. Infection related to implanted medical devices is directly related to bacterial capability to establish multilayered, highly structured biofilms on artificial surfaces. Bacterial infections due to implanted biomaterials represent the most devastating complication in O&T, involving millions of European citizens. Aim of the present research is to develop, validate and bring to the market a disposable coating of implanted biomaterial (Implant Disposable Antibacterial Coating, I.D.A.C.). The device, based on a novel, proprietary, resorbable hydrogel, would act as a fast resorbable local delivery carrier of antibiofilm and antibacterial compounds. The active drug (antibiofilm and antibiotic agents) will be mixed at the time of the hydrogel application, allowing the correct choice for any given patient, reducing regulatory requirements, improving storage life and versatility. In particular, I.D.A.C. will be tested as a resorbable carrier of drugs (e.g.: N-acetylcisteine and its derivatives, serratia peptidase and other peptides, etc.) already known from our studies for having excellent antibiofilm properties, while others are able to by-pass the intact biofilm barrier and kill the underlying bacteria, when locally administered. The final purpose of the present research is to set a novel approach to early control of biofilm formation,to prevent bacterial colonization of implanted material and to treat established implant-related infections and chronic wounds, without any risk of inducing new drug resistance and alter the environment. The research will be conducted under the aegis of the European Bone and Joint Infection Society and the European Hip Society, through a network of upper standard European research and clinical centers and experienced SMEs from eight Countries around Europe.

Keywords: hydrogel,coating,orthopaedics,traumatology,implants,wounds,infection,biofilm