Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reactor-based enhanced rock weathering system with measurement, reporting and verification for Carbon capture and storage (React Carbon)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The escalating global emissions of greenhouse gases threaten our planet's foundation. Atmospheric CO2 levels have reached 422 ppm, with an annual increase of 2.5 ppm; we are already witnessing the catastrophic effects on ecosystems, economies, and human societies worldwide. The main challenge for CO2-emitting industries is complying with the EU Emissions Trading System (EU ETS) and thus, quickly deploying cost-effective solutions that will ensure this compliance. The actual price in 2024 corresponds to €65 per ton of CO2 equivalent. BloombergNEF expects the price will stay at this average during this year, before more than doubling to €146/t by 2030. Planeteers has developed an innovative solution, to store CO2, that mimics the natural weathering of limestone but accelerates it from thousands of years to just a few minutes using the same natural ingredients. CO2 from biogenic or fossil point sources is dissolved in water through our scrubber and mixed with a limestone (CaCO3) solution in our alkalinity reactor. During the reaction, CO2 is converted into bicarbonate (HCO3-) and stored in the water. After equilibration with the atmosphere and the local aquatic environment in our diffuser system, it can be released in a controlled way to water bodies which transport the mineralized water to the ocean. There, the CO2 is stored as bicarbonate on a long-term basis (10,000-100,000 years) helping at the same time to reduce the water acidification locally. The Compliance carbon market (CCM) is our target for entry supported by the EIC Accelerator. The REACT CARBON project lays the foundation for our expansion into the CCM, emphasising its strategic importance. We will focus initially on cement and limestone industries emissions: they currently emit around 160 million tons of CO2. Considering the EU Fit-for-55 reduction targets and CCS prices increasing to €146 per ton, Planeteers market value in the EU is conservatively estimated to be at least €2.0 billion.

Keywords: co2 removal,reactor based enhanced weathering,ocean alkalinity enhancement,alkalinity reactor
InterGENerational Youthful Narratives: ARTs-Based Approaches to Digital Citizenship and Civic EngageMENT (GENARTMENT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 191343.12
EU funding (EUR): 191343.12
Participants: 1
Project status: SIGNED

This project explores how arts-based methods and community-based research principles can strengthen civic engagement among young people and enhance the digital participation of older adults. Positioned at the intersection of sociology of childhood/youth, ageing and cultural sociology, the study focuses on youthful narratives to facilitate two-way knowledge transfer through intergenerational communication, using a life course perspective. The main objectives are: exploring children's digital citizenship experiences by understanding the interaction between analog and digital realms; strengthening intergenerational relations through arts-based methods to foster solidarity; and enhancing civic participation and participatory culture among young people as a crucial democratic heritage. The first two objectives are interconnected through arts-based methods, while the second and third are linked through intergenerational communication and collaboration. The first and third objectives promote democratization through digitalization and use art as a tool for emancipation. Art and literature aim to evolve perspectives on childhood and empower participatory culture by sharing reciprocal youthful narratives. GENARTMENT targets small communities, including children, youth, and older adults, engaging them in the research process through co-design and co-implementation with a citizen science approach. The project involves several stages: creative data collection, integrating participatory and arts-based research methods, enhancing methodology through collaboration with children, conducting interviews to explore their digital experiences, and story collection with children and their elders through creative workshops. These stages aim to develop tools for building connections between people of various ages, exploring their past and present childhood experiences, memories, and adult imaginaries of the present and the future.

Keywords: sociology of childhood childhood and youth studies qualitative research participatory research
Clinical validation and preparation for regulatory approval of the Psyros (TM) high-sensitivity point-of-care troponin test. (DigiPOC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 1470000.0
EU funding (EUR): 1470000.0
Participants: 1
Project status: SIGNED

Over 10 million patients attend emergency departments across Europe each year with chest pain and suspected heart attack. However, the vast majority (>90%) are not having a heart attack and are blocking up already crowded emergency departments. A significant proportion of these patients can be safely discharged after having a blood test for a molecule called troponin that leaks from the heart muscle when it is starved of oxygen. If the troponin concentration in the blood is low enough, then a proportion of patients can be ruled out immediately (SINGLE-POINT RULE-OUT). If not ruled out immediately, then a second test is run after 1 hour to measure whether the troponin concentration is rising or not (0-1 HOUR ALGORITHM). Measuring troponin using a point-of-care device would bring many benefits, but the troponin concentration is so low that this is technically very challenging. There are no point-of-care high-sensitivity troponin tests that have been fully validated for single-point rule-out or the 0-1 hour algorithm based on the most recent recommendations from the International Federation of Clinical Chemistry. Prolight are developing a point-of-care immunoassay platform (reader and disposable cartridge) that allows single molecule counting to be carried out in whole blood, without separation of the cells. Each binding event is used to bleach a dark spot in a fluorescent sensor surface, and the sensor is then imaged using a miniaturized optical module. The technology is simple, yet very powerful and amenable to cartridge manufacture at low cost. The team are very experienced and have taken product from concept to market previously. Deliverables from this project will include the finalization of the assay design freeze, system validation and initiation of stability studies. This will be followed by clinical study set-up and execution, then preparation of the technical file for regulatory approval by a notified body. Commercial launch is planned for 2026.

Keywords: in vitro diagnostics troponin cardiology
Optimized Production And Trials Of Innovative Macrophage Drug Conjugates For Solid Tumors (OPTIMAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Poland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Solid tumors, including glioblastoma, head and neck cancer, uterine cancer, bladder cancer, and lung cancer, are notoriously difficult to treat due to drug resistance, tumor heterogeneity, and an immunosuppressive microenvironment, resulting in poor patient outcomes. Current cell-based therapies offer hope but face challenges like autologous limitations and small manufacturing batch sizes, which increase costs and complicate logistics, limiting accessibility and scalability. Our project aims to revolutionize cancer treatment with the Macrophage Drug Conjugate (MDC) platform, which employs the TRAIN mechanism to deliver therapeutic agents directly into cancer cells. This technology targets even hypoxic and resistant tumor regions, transforming the tumor microenvironment to enhance immune response and potentially prevent recurrence. The project's dual focus is to optimize the large-scale manufacturing of these allogeneic, off-the-shelf macrophages, ensuring their availability and affordability, and to establish clinical evidence of their efficacy in treating solid tumors. This innovative approach seeks to overcome the significant barriers in cancer therapy and cell-based treatment production, providing a new, scalable solution for patients globally. By advancing MDC technology, we aim to make groundbreaking cell-based therapies more accessible and effective, ultimately transforming the treatment landscape for solid tumors.

Keywords: macrophages,solid tumors,cell based therapies,glioblastoma,head and neck cancer,uterine cancer,bladder cancer,lung cancer
Sensing and Model-based Approach for Reliable and Timely bridge rehabilitation enhancement (SMART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Ireland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

Effective and timely bridge maintenance is critical to ensure their long-term structural integrity and safety. This project presents an innovative approach to bridge maintenance that integrates acceleration data collected via smartphone from vehicles crossing the bridge daily into the continuous process of updating finite element models (FEMU). The project develops a strategic maintenance plan for bridges that optimizes resource allocation and improves the overall performance of bridge structures. The integration of acceleration data with the continuous FEMU enables a comprehensive assessment of the structural condition of a bridge and real-time monitoring. Acceleration data collected using smartphones is used to extract the dynamic response of the bridge under different load conditions and integrated into a finite element model of the structure and its continuous updating. The model is updated to accurately represent the current state and performance characteristics of the bridge. By combining real data with computer models, this project provides engineers and maintenance professionals with deep insight into structural behavior. This information serves as the basis for developing a strategic maintenance plan. The plan includes recommendations for inspections, repairs, and maintenance actions based on the actual condition of the bridge, prioritizing critical areas that require immediate attention. This innovative approach improves safety by enabling proactive maintenance and reducing the risk of unexpected structural failures. It also optimizes government budgets for maintenance by efficiently allocating resources to areas where they are most needed, thereby extending the life of bridge structures and minimizing downtime for repairs. In summary, it represents a significant advance in bridge maintenance practice, ensuring the long-term durability and safety of critical infrastructure while optimizing the use of resources.

Keywords: structural health monitoring,drive by bridge monitoring,finite element model updating,brigdes,rehabilitation
Understanding and PreDicting the Rapid development of storms: A new ForecasTing framework (UPDRAFT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-04
End date: 2027-08-03
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Developments in numerical weather forecasting have been of great benefit to many sectors of society. However, state-of-the-art weather forecasting and climate models still struggle to predict the onset and development of convective storms over land. Such storms are associated with many destructive weather events including floods, hail, and lightning, and thus, any improvement in addressing these events remains keenly sought after. UPDRAFT will develop a new method for the representation of convective storm clouds in forecasting models, building a completely new theoretical framework that can overcome many of the problems with the current modelling approach. Recent studies by the ER have shown that some key physical mechanisms responsible for the initiation of convective storms are neglected by current models, which might explain the large biases associated with the prediction of these storms. In the new model to be developed during the fellowship, these missing mechanisms will be represented in a more physically-based picture for the development of convective clouds. The main objective of the project is to produce concrete evidence that the new framework can lead to much-improved forecasts of storms. Besides the immediate potential impact for weather prediction, the outcome of the fellowship will also help in improving our understanding of storms and their response to climate change. Convective clouds play an important role in the Earth’s radiative and hydrological budgets, so the project might help in improving climate models as well, supporting decision-making on adapting to climate change and mitigating the risks associated with many severe weather events.

Keywords: convection,clouds,storms,weather forecasting,climate modelling
AI powereD characterization and modelling for GREEn STeel technology (AID4GREENEST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,Finland,Germany,Poland
Call: Advanced materials modelling and characterisation (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 5334182.5
EU funding (EUR): 5334182.5
Participants: 11
Project status: SIGNED

The fourth industrial revolution and market demands for advanced steels are driving the research towards transformation of the manufacturing processes and to ever-more sustainable steel compositions. The conventional ‘trial and error’ approach traditionally used to develop metallurgical processes still prevails in the industrial steel plants. However, it is a time-consuming, labour-intensive process entailing high material waste and associated carbon emissions. Also, it can ultimately lead down to a repetitive path that consists of creating a process design, putting it into production, and detecting possible process design flaws too late, resulting in high component rejection rates. Ascertaining the inadvertent flaws in the manufacturing approach before its implementation on industrial lines could be the key to major cost savings. With the introduction of AI- and simulation-driven design, back-and-forth interaction between part and process designs can be significantly diminished. The main objective of AID4GREENEST is to develop six new AI - based rapid characterization methods and modelling tools. AID4GREENEST tools’ scope will cover the steel design (chemistry and microstructure), process design (processing parameters), product design (processing and heat treatments) and product performance (creep) stages. Proposed tools will be complemented with a roadmap designed to enable model-based innovation processes, from materials design to product development, while considering the industry needs: enhanced material quality, reduction of carbon emission and waste generation, and reduced supply risk of critical raw materials. In order to facilitate the knowledge transfer of the characterization and modelling data generated in this project and across the wider European characterization and modelling community, the project will also develop an open online platform, based on a standardized and interoperable data management system and following the EMMC, EMCC and EMMO approach.

Keywords: artificial intelligence computational screening tool characterization data interoperability open repository
Disentangling the early-life environmental determinants of pediatric LIVER injury: An eXposome-wide approach (LIVER-X)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

LIVER-X addresses an important question: how does the environment impact the developmental origins of liver health and disease? Poor liver health in childhood represents a major public health problem with long-term consequences. Elevated alanine aminotransferase, a marker of liver injury and screening tool for pediatric non-alcoholic fatty liver disease (NAFLD) risk, is increasingly reported at young ages, currently being detected in almost one out of ten children living in Europe and the western world. Although it is well known that an obesogenic diet and genetic predisposition play a role in the development of liver injury and disease, the contribution of the complex environment in which we grow up and live remains unclear. LIVER-X addresses this knowledge gap. The project will leverage the resources of the population-based HELIX and Generation R cohorts and follow an exposome-wide approach to the study of environmental impact by using rich biomonitoring and geospatial exposure data collected at the vulnerable early stages of the lifecourse (pregnancy and childhood). Advanced analysis techniques will be used to provide novel evidence on the individual and combined effects of a wide array of early-life ubiquitous environmental factors, including industrial chemical pollutants, toxic metals, air pollution, and characteristics of the urban natural and built environment, on liver injury markers in childhood and adolescence. The project will also assess whether children’s diet quality and polygenic risk for NAFLD modify vulnerability to environmental impact, and thus aid in identifying susceptible subpopulations and environmental priorities. LIVER-X fosters research cooperation across disciplines and knowledge transfer. The project aligns with urgent challenges related to environmental pollution, the urban environment and the health of future generations, and thus its results are expected to be of high relevance for researchers, policy makers, and European citizens.

Keywords: exposome,early life,environmental pollutants,urban environment,pregnancy,childhood,child health,liver injury,nafld risk,gene environment interactions,diet quality
Targetting neutrophil-mediated neurotoxicity for the treatment of Alzheimer's Disease (NeutrAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

With the NeutrAD ERC PoC project, we present the first disease-modifying Alzheimer’s Disease (AD) drugs that abrogate leukocyte-mediated neurotoxicity and represent a novel class of drugs in the treatment of AD. AD is a neurological disorder characterized by progressive deterioration of cognitive function and leads to death within 3-9 years after diagnosis. AD is highly prevalent in elderly, and it is estimated that 35M patients suffer from the disease worldwide. As a result, AD has tremendous social and economic impact. This is aggravated by the lack of disease-modifying drugs, as current therapies only provide short-term symptomatic benefit. Hence, novel therapeutic approaches are of critical importance to resolve this urgent and growing health crisis. Our novel anti-AD drug candidates use a neutrophil-targeted approach and unlock a novel avenue for the millions that suffer from AD. Growing evidence supports the role of inflammation in the development of neurodegeneration in AD. For example, our previous research has demonstrated a role for neutrophils in the induction of memory decline and neuropathological hallmarks of AD. Furthermore, our data shows that a highly activated and degranulating neutrophil phenotype induces neurotoxicity in an in vitro AD context. Preliminary results have also demonstrated that our novel drug candidates rescue neuronal death and have disease-modifying potential in AD-like mouse models. In NeutrAD, we will explore the technical and commercial potential of our drug candidates as the first disease-modifying drugs against AD. Specifically, we will optimise and subsequently test the technical feasibility of our two drug candidates in AD-like in vitro and in vivo models. In parallel, we will explore the commercial opportunity of our novel AD drugs and analyse the IP position and strategy, as well as the market and (existing and emerging) competitors. Finally, we will consolidate the project outcomes in an investor-ready business plan.