Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Integron Cassette Dynamics and the Integrase Gene Expression (ICADIGE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 193594.8
EU funding (EUR): 193594.8
Participants: 1
Project status: CLOSED

Bacterial antimicrobial resistance has become one of the major concerns in modern medicine. It is currently responsible in Europe for 15 times as many deaths as AIDS every year. Not surprisingly this phenomenon is one of the Top Six Health Topics for the eCDC. Bacteria have shown a remarkable evolvability towards resistance. One of the most worrisome mechanisms observed, is the integron, a highly efficient gene-recruitment platform. In addition to rising resistance, there are no encouraging perspectives in the drug discovery field. Thus, containment is the major asset in combating resistance. Nevertheless new and creative approaches are being assessed. A good example is the study of molecules against the integrase. A deep knowledge on the integrase’s activity and its regulation is at the basis of any major achievements in the field. This project aims to better understand integrons and to acquire new knowledge that will ultimately help combat antimicrobial resistance. The first set of experiments will unravel the behaviour of integrons in vivo. By developing a mouse model, we will study the influence of antibiotic therapy in the integrase induction through SOS response in the gut. Further work will be focused on the in vivo integron/plasmid synergy, as single stranded DNA transmission during conjugation can trigger integrase activation in vitro through SOS response. Such interaction is especially worrisome as many resistance plasmids carry resistance integrons.This data will help understand the behaviour of integrons and the dynamics of integrases in their natural environment. Altogether, the results of this project will mean a breakthrough in understanding the evolutionary potential integrons confer to bacteria. This knowledge will definitely help develop efficient tools to fight antimicrobial resistance.

Keywords: medical microbiology,antimicrobial resistance,bacteriology,integron,integrase,sos-response,rivet,in-vivo,gut microbiome,bacteria-host interaction
The role of TREM proteins in inflammatory lung disease (ALLOSERGON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-02-01
End date: 2016-12-23
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

• Both asthma and pneumococcal infection independently affect millions of people world-wide causing significant mortality/morbidity and an associated high economic burden. It is indicated that pathogenesis in asthma is due to enhanced bacterial replication and invasiveness in the lung rather than a worsening of asthma itself. • The overall scientific objective is to combine established models of respiratory bacterial infection and house dust mite induced asthma in the mouse. This project is a new approach to identify the molecular mechanisms and the involvement of the novel surface receptor proteins TREM. Airway macrophages of the asthmatic lung will be analysed by high throughput flow cytometry, cell sorting, immunohistochemistry and cytokines measured by ELISA to identify innate immune alterations. It is indicated that the bacterial complications that occur in patients with underlying lung disease are due to an up-regulation of anti-inflammatory TREM-2 or a loss (via secretion) of membrane bound TREM-1. The main aim is to provide the key tools to reduce the severity of bacterial complications in asthma and identify targets for prophylactics/therapeutics. • High level supervision, specific training by experts in the set up of in vivo respiratory infection models, access to state-of-the-art equipment will enhance my position at the forefront of advances in this field. Strong interaction with other international researchers will enable transfer of knowledge and contribute to a sustainable network. The unique opportunity to attend leadership and management courses will allow me to reach scientific maturity and gain independence as a researcher. • This project fulfils all the ERA criteria and will notably contribute to Europe’s Vision 2020. The resultant publications in high impact factor journals will contribute to the worldwide recognition of European research and significantly strengthen the EU over US competitors in pulmonary chronic disease and infection.

Keywords: health sciences,chronic diseases,bacteriology,cell biology,lung,bacteria,cellular mechanisms,immunology,asthma,innate immunity,toll like receptors,respiratory bacterial infection
Women Practitioners of Tibetan Medicine and the Modernisation of Health Care (TIBETANMEDICA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-12-31
Duration (months): 24.0
Total project cost (EUR): 208353.6
EU funding (EUR): 208353.6
Participants: 1
Project status: CLOSED

Since the 1980s there has been a growth in the numbers of female Tibetan medicine practitioners, the so-called amchi, in areas where the Tibetan ‘science of healing’ (sowa rigpa) is practiced: Tibetan areas of China, the Tibetan exile community in India, in Bhutan, Ladakh, Nepal, and in Buryatia and Mongolia. It is currently little understood how the increasing numbers of women amchi have come about, what challenges and opportunities this growth has fostered for themselves and their patients, and what its health outcomes are. Using a combination of historical and ethnographic methods, and a case study approach based on research in the Tibet Autonomous Region (TAR), Bhutan and the Tibetan exile community in India, this project will document and analyse the life stories and medical work of modern day female amchi. The research will investigate and analyse the effect of amchi’s gender on patients and overall community health, in particular through the opening up of a new field of women and children’s health care within Tibetan medicine. The proposed project is firmly situated in the context of rapid modernisation of traditional health care. It will identify important features of gendered sowa rigpa knowledge and practice beneficial to patients, as well as possible transformations through developments in the modernisation of sowa rigpa. The results of this study are expected to provide a solid basis for any academic, political or medical engagement with Tibetan medicine and with health care and community medicine in the areas under study. The outcomes may have the potential to guide future health policy in the domain of women and children’s health in Tibet, Bhutan and among exile-Tibetans. This endeavor is highly innovative. There is no comprehensive study of professional female amchi so far, nor is there research on the impact of their work on community health. Yet it has been shown that gender is a crucial factor in the delivery and outcome of health care.

Keywords: tibetan medicine,sowa rigpa,female medical practitioners,gender,modernisation of health care,community health,social sciences,medical anthropology,medical history,asian medicine
Microbial community nano-ecotoxicology: interplay between effects on structure and the consequent effects on function. (MICRONANOTOX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-01
End date: 2014-04-30
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Nanotechnology is already used in a huge variety of applications with a resulting potential environmental exposure. However, we are still lacking sound scientific knowledge on the ecological consequences for natural environmental systems of exposure to man-made nanoparticles (NPs). While standard ecotoxicity tests can be modified for hazard assessment of such NPs, the tests and therefore the conclusions address the wrong endpoints such as high-dose effects on survival and reproduction. This may have little relevance to possible effects on structure and function of natural ecosystems predicted to be exposed to low doses. Therefore the overall aim of this project is to link modern molecular biology and nano-ecotoxicology to address the interplay between effects of engineered NPs on microbial community structure and function and the consequent effects on their ecosystem function roles and rescilience. By joining the disciplines of community ecotoxicology, modern molecular biology, high end NP characterisation techniques together and bringing their combined abilities to bear on natural microbial comunities collected from both aquatic and soil environments this project will contribute to an environmentally more realistic hazard and risk assessment of NPs for microbial communities. This project will use both true commercial and purpose designed examples of silver (Ag)- and zinc oxide (ZnO)-NPs both NP types being among the commercially most important NPs these days. An additional focus will be set on systematic investigations of how effects are governed by the NPs fate and behaviour in relation to the respective environmental matrix and crucial abiotic key factors. The data will be submitted into a broader research context through major EU and UK-US projects analysing the environmental effects and hazards of NPs to contribute to the development of suitable hazard and risk assessment strategies for the special demands of NPs.

Keywords: ecotoxicology,freshwater and terrestrial ecosystems,microbial communities,genetic diversity,ecosystem functioning,metal nanoparticles,environmental hazards,bioavailability,biogeochemisty
Exploring the role of mitochondrial dynamics in tumor regulation by Cop1 (COP1-DRP1)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 256364.2
EU funding (EUR): 256364.2
Participants: 1
Project status: CLOSED

The Constitutive morphogenetic protein 1 (Cop1) is an E3-ubiquitin ligase regulating stability of a broad group of targets with pleiotropic functions. Cop1 emerged as a tumour suppressor in T-cell lymphomas and in prostate cancer. During tumour formation, mitochondria are key organelles regulating cell death and proliferation. This multiplicity of functions is mirrored by the complex morphology of the organelle, resulting from the equilibrium between fusion and fission, events controlled by a set of mitochondria-shaping proteins. Fission depends on the large GTPase dynamin-related protein 1 (DRP1), essential for embryonic development and involved in the control of apoptosis and cell cycle.We found that loss of Cop1 results in increased cell death, DNA damage, mitochondrial fragmentation, and accumulation of D1, highlighting a potential connection between a tumour suppressor and mitochondrial morphology. We therefore hypothesize that Drp1-mediated regulation of mitochondrial morphology participates in tumour suppression by Cop1. To address this hypothesis, we will verify if (i) Drp1 is epistatic to Cop1 in accumulation of DNA damage and sensitivity to cell death; (ii) Drp1 is required for lymphomagenesis in Cop1h/h mice . Our project is expected to establish the role of mitochondrial morphology in Cop1 regulated tumour development.

Keywords: cancer,mitochondria,ros,cell death,cop1,lymphoma,t-cell,drp1,fragmentation,metabolism,apoptosis,dna damage
B-reactable: multimodal tabletop system for collaborative physiology monitoring and training (B-REACTABLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2013-02-22
End date: 2015-02-21
Duration (months): 24.0
Total project cost (EUR): 188323.8
EU funding (EUR): 188323.8
Participants: 1
Project status: CLOSED

Rapid development within the biomedical engineering field, especially Brain-Neural-Computer Interaction (BNCI) area, provides a solid technological base for new applications aimed at improving health and quality of life. In this project, aimed at combining research and training components, Dr. Valjamae will design, validate and optimize a novel multimodal system - B-Reactable - linking a tangible musical tabletop interface with BNCI technology for collaborative physiology monitoring and training in future health and professional applications. This interdisciplinary research project is based on the joint pilot work with Prof. Jorda, University of Pompeu Fabra, Barcelona in 2010-11. The project is designed to be a vehicle for the training and consolidation of the research outcomes for further exploitation in the EU. In the envisioned B-Reactable applications, users will explicitly or implicitly learn to monitor and control their physiological signals using tangible objects, and hence, understand and influence their cognitive or emotional states. The project will reinforce the international dimension of applicant’s scientific career by giving him the opportunity to be trained and acquire new knowledge in the Russian Federation, under direct guidance of Prof. Kropotov at the “Institute of Human Brain”, Russian Academy of Science (IHB-RAS) and Dr. Ossadtchi at St. Petersburg’s State University (SPSU). Prof. Kropotov is one of the leading neurofeedback scientists, with over 30 year research in computational models, normative databases, new paradigms and analysis methods, and extensive work on healthy adults, children and various patient groups. After training at IHB-RAS, Dr. Valjamae will bring his new experience and tangible outcomes to the renowned Swedish Institute for Disability Research at Linköping University, where together with Prof. Vastfjall he will test and further refine B-Reactable, targeting cognitive aging for improving users quality of life and wellbeing

Keywords: biomedical engineering,neuropsychology,interactive surfaces,neurophysiology
Fate and effects of Pharmaceuticals in Soil-Plants System (PHARMASOILS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2016-03-03
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Large amounts of pharmaceutical compounds, from a wide spectrum of therapeutic classes, are used and prescribed in human and veterinary medicine worldwide. Following use, pharmaceuticals may be metabolised and will then be excreted in the urine and faeces. The resulting manure, slurry and sewage sludge will then typically be applied as a fertiliser to agricultural land. A wide range of pharmaceuticals (hormones, antibiotics and parasiticides) has been detected in manure, sewage sludge and soils throughout the year and some substances may also persist in the environment for months to years. A number of pharmaceuticals have been shown to be accumulated by plants and could result in negative effects. Therefore this study will employ a systematic approach to investigate the mechanisms of uptake and toxicity of medicines in plants and the implications of these in terms of crop productivity and the safety of plant-derived foodstuffs to humans.

Keywords: pharmaceuticals,plants,uptake,metabolites,modelling,biochemistry,toxicity
Predictive ecology of global species extinction risk for conservation (PRESERVATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2013-03-01
End date: 2015-08-14
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

While there is no doubt that biodiversity is seriously at risk across the globe, there are considerable gaps in the geographical and taxonomical coverage of existing knowledge on species at risk. Thus, one of the most pressing issues currently facing the global conservation community is how to efficiently predict which species are most at risk, while the information at hand is often incomplete, and concentrate the limited resources available on those priority species. It is thus urgently needed to test if existing knowledge that has been accumulated for a particular species in a particular region can be used effectively to predict extinction risks of other species in other regions. This project aims to develop predictive models of species extinction risk and test the interregional applicability of the developed models globally. Waterbirds will be used as the study species because both population count data and information on species characteristics and habitats are available for most species across the globe. Thus, focusing on waterbirds would provide a rare opportunity to estimate extinction risks in different regions and for over 700 different species, and test the effects of different predictors on the estimated extinction risks across the globe. The project consists of three steps: (1) estimating the extinction risk for waterbird species using hierarchical Bayesian models, (2) developing models to predict extinction risks in each region, (3) cross-validating models between different regions and exploring factors that explain the difference in model performance among regions. This project will represent the first global-scale scientific effort to estimate the extinction risk for waterbird species with a dataset derived from a systematic survey. More importantly, the project aims to establish a novel predictive framework for assessing species extinction risks and provide a breakthrough to tackle the lack of information on global biodiversity status.

Keywords: biodiversity status and trends,biodiversity loss,extinction risk,hierarchical bayesian models,incomplete information,predictive models,phylogeny,species traits,2010 biodiversity target
Towards Enhanced III-V Tunnel Transistors (TETTRA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

Tunnel transistors are currently considered promising candidates for future low-power high performance information processing applications. The proposed project TETTRA – Towards Enhanced III-V Tunnel TRAnsistors – is dedicated to the fabrication and characterization of III-V nanowire tunnel field-effect transistors (FETs). III-V semiconductor heterostructure nanowires, grown on Si substrates by means of the selective-area-epitaxy method, serve as basis for the tunnel FETs. The project concentrates on n-type tunnel FETs and furthermore focuses on one specific realization with regard to the choice of materials involved; i.e. n-type tunnel FETs consisting of a p-type GaSb source, an InxGa1-xAs channel, and an n-type InAs drain. This sequence of III-V materials is grown in the form of vertical heterostructure nanowires directly on silicon substrates, with InAs being in contact with the substrate and GaSb forming the nanowire tip. The heterostructure nanowires are then processes into vertical, gate-all-around tunnel FETs. The fabrication of the nanowire heterostructure and the processing of the III-V nanowire tunnel represent one of two main objectives of the project. Investigations on the growth of GaSb on InxGa1-xAs, on the p-doping of GaSb, and on metal contacts to GaSb are preceding the tunnel FET fabrication. The second objective of the project comprises the electrical characterization of the nanowire-oxide interface properties and the electrical characterization of III-V tunnel FETs. For characterizing the nanowire-oxide interface properties two independent techniques will be employed: capacitance-voltage measurements and the charge-pumping technique. Both deliver the interface trap level density, Dit, and both have been demonstrated to be applicable to single nanowire capacitors and FETs, respectively. Characterization is complemented by detailed investigations of the electrical properties of the III-V nanowire tunnel FETs.

Keywords: physical sciences