Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Monitoring of Environmental Practices for Sustainable Agriculture Supported by Earth Observation (ENVISION)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Innovation actions
Countries involved: Cyprus,Serbia,Belgium,Lithuania,Belgium,Greece,Slovenia,Serbia,Greece,Greece,United Kingdom,United Kingdom
Call: Development of commercial activities and services through the use of GEOSS and Copernicus data (H2020-SC5-2019-2, 2019)
Start date: 2020-09-01
End date: 2023-11-30
Duration (months): 39.0
Total project cost (EUR): 3162606.25
EU funding (EUR): 2735856.25
Participants: 13
Project status: SIGNED

ENVISION aims to fulfil the need for continuous and systematic monitoring of agricultural land, shifting the focus from fragmented monitoring limited to specific fields and dates to territory-wide and all-year-round monitoring. It will make use of heterogeneous types of available data (EO-based, in situ, open data, and historical on-field check data) and state-of-the-art technologies and methodologies (automatic pixel/texture/object oriented change detection and classification methods, machine learning, data fusion, multi-source and multi-temporal data management) for providing a fully-automated and scalable toolbox of services, built in close interaction with its future customers. ENVISION will fully exploit the wealth of data made available through GEOSS and Copernicus and its synergetic use with other data to develop data products such as: Cultivated crop type maps; Soil Organic Carbon; Vegetation status; Crop growth (distinction of organic – conventional farming); Grassland mowing/ploughing; Soil erosion. The ENVISION toolbox will be comprised of: a monitoring service of sustainable agricultural practices, tools that PAs & CBs can provide to farmers for adhering to environmentally friendly agricultural practices, an Add-on Development Tool. The project will be tested and validated in a pre-operational environment by potential future customers of its products and services. ENVISION will have three categories of business cases (Monitoring of: multiple environmental and climate requirements of CAP, soil condition, organic farming requirements) and will also be tested by a group of Lighthouse Customers. A market analysis, business model experimentation techniques and appropriate decision-making tools will determine the commercially viable business models for the services and products of ENVISION, and define alternative business models, understand their implications and identify those that will create the greatest value.

Keywords: common agricultural policy,earth observation,commercial services and products,environmentally friendly agricultural practices
Exoplanet Adaptive Characterization with the ELT (EXACT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France,France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2744119.0
EU funding (EUR): 2744119.0
Participants: 2
Project status: SIGNED

This proposal’s objective is to mature two novel technological developments to push the limits of high-contrast imaging at high-spectral resolution with the near-future extremely large telescope (ELT). I will replicate in the laboratory the observing conditions of the ELT, and the expected spectra of a variety of planets and stars using tunable lasers. First, the high-contrast imaging system of HARMONI will be emulated to produce realistic datacubes onto which post-processing algorithms will be applied to extract as best as possible the planet signal to prepare for the real observations in 2025, which will be key to understand how planets form. I will then develop two complementary technologies. The first one is a novel type of spectrometer specifically designed to characterize an exoplanet at a high spectral resolution with a high throughput, and it will be tested on sky by being coupled to state-of-the-art direct imaging instruments (KPIC & SPHERE) both to validate this concept and to provide the highest resolution spectra of young giant planets ever obtained. A very innovative variation of this spectrometer will turn it into an integral field spectrograph with a FoV perfectly suited for the characterization of planets in the habitable zone of nearby M-dwarves. The second one is an adaptive coronagraph based on an achromatic amplitude control system, which, coupled with an adaptive optics system, will maximize the SNR of the planet by creating contrast only where it is required, in spite of ever-changing amplitude and phase aberrations due to the ELT and its instruments. These technologies will be combined together on the ELT testbench to test its ultimate capability, and lead a consistent proposition for a dedicated ELT instrument design to characterize faint planets in the HZ of nearby stars, and assess the habitability.

Keywords: high contrast imaging,high resolution spectroscopy,coronagraphy,moems,molecular mapping
EndoMapper: Real-time mapping from endoscopic video (EndoMapper)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,France,United Kingdom,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 3693477.5
EU funding (EUR): 3693477.5
Participants: 5
Project status: SIGNED

Endoscopes traversing body cavities such as the colon are routine in medical practice. However, they lack any autonomy. An endoscope operating autonomously inside a living body would require, in real-time, the cartography of the regions where it is navigating, and its localization within the map. The goal of EndoMapper is to develop the fundamentals for real-time localization and mapping inside the human body, using only the video stream supplied by a standard monocular endoscope. In the short term, will bring to endoscopy live augmented reality, for example, to show to the surgeon the exact location of a tumour that was detected in a tomography, or to provide navigation instructions to reach the exact location where to perform a biopsy. In the longer term, deformable intracorporeal mapping and localization will become the basis for novel medical procedures that could include robotized autonomous interaction with the live tissue in minimally invasive surgery or automated drug delivery with millimetre accuracy. Our objective is to research the fundamentals of non-rigid geometry methods to achieve, for the first time, mapping from GI endoscopies. We will combine three approaches to minimize the risk. Firstly, we will build a fully handcrafted EndoMapper approach based on existing state-of-the-art rigid pipelines. Overcoming the non-rigidity challenge will be achieved by the new non-rigid mathematical models for perspective cameras and tubular topology. Secondly, we will explore how to improve using machine learning. We propose to work on new deep learning models to compute matches along endoscopy sequences to feed them to a VSLAM algorithm where the non-rigid geometry is still hard-coded. We finally plan to attempt a more radical end-to-end deep learning approach, that incorporates the mathematical models for non-rigid geometry as part of the training of data-driven learning algorithms.

Keywords: visual slam,deformable visual slam,machine learning for endoscopy
Multidisciplinary approach to multilayer monumental sites studies: the case of the Quirinal Hill in Rome (MuMoSiSt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The multiplicity of different historical phases can be considered one of the most singular characteristics of cultural heritage. Until today it has been clear that the scientific approach to this issue should use the developmental process as the main tool for both defining the historical phases and understanding the current state of historical heritage. Generally, it is necessary to distinguish between the diachronic and the synchronic studies, but at the same time it is mandatory to evaluate the connection between different historical layers. These opposing needs still represent a big problem that historical sciences are not always able to manage. The desirable multidisciplinary approach often produces mediocre results, while individual research generally lacks the complexity that always characterizes conservation and valorisation issues. Thus, the research project aims to discover a methodological approach that can bridge the gaps that are now often apparent between different studies. The main research goal is to define a specific digital platform for the management and consulting of the outcomes provided from the different scientific fields involved. This structure will allow to share the data collected easily, giving information about the different historical phases of a site as well as a global assessment based on its most significant transformations. The area of the ancient Temple of Serapis on the Quirinal Hill in Rome should be a good case study, that's mainly because of its complex stratigraphy. The research aims at covering the whole development period of the area by means of systematic data collection. The analysis of all different temporal phases will be fundamental for the implementation of a methodological strategy, able to involve different experts. The benefit of a web accessible digital platform able to collect all the diverse data, would be evident in the final step, when digital drawings based on new multimedia technologies will be produced.

Keywords: computer humanist,digital heritage
Understanding the relationship between mother-tongue and father-land among German-Jewish thinkers of the XX century (HOME-LANG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

National identities are, broadly speaking, built on the historical correspondence between homeland and language. Still, this combination does not apply to Diaspora communities and notably to Jews, whose identity along centuries was rooted in a displaced homeland and spread over distinct languages. How should the bond between homeland and language among German-Jewish thinkers of the XX century be conceptualized? Specifically, what is the exact relationship between mother-tongue and father-land and which role does the gender dimension play in this conceptual pair? How did historical events, such as the Shoah and the foundation of the state of Israel, reshape this relationship? With the aim of examining the bond between language, identities and exile, the HOME-LANG (acronym of the project) will build on my expertise in Jewish contemporary philosophy on the one hand, and on the skills in archival methodologies developed at the University Pompeu Fabra of Barcelona (UPF) on the other. The results of the project will boost my scholarly profile at the international level; they will consolidate UPF as an interdisciplinary hub for cutting-edge research on Diaspora and Jewish studies; finally, they will foster communication between scholars, practitioners and general public at the core of contemporary debates on migration, multiculturalism and the construction of a shared European identity.

Keywords: jewish contemporary philosophy,language,diapora,homeland,gender,shoa
Novel pressure relieving and sensing mattress and an intelligent control system that predicts and prevents pressure ulcers in bedridden patients (Qone)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Denmark
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ReQbo is developing a disruptive system for preventing pressure ulcers (PU) in bedridden patients by intelligently and continuously assessing a personalized risk score for each patient. This system is the first market solution offering active preventive care, instead of the reactive care that is enabled by competing technologies. Accordingly, the system will be capable of contributing to a steep reduction in PU incidence in long-term care units, both in hospitals and nursing homes. Treating pressure ulcers is very costly, accounting for more than €20 billion per year supported by EU public healthcare systems. Prevention and early detection are the main priorities to reduce this current healthcare burden. Despite improvements in healthcare systems and technologies, patients are still at risk of developing pressure ulcers, because of ineffective and incomplete routine care to assign preventive measures. With current technologies and clinical practices, patients in need of prevention cannot be accurately and reliably detected, which lead to PU development. While the treatments options are well established once a patient has been diagnosed with high PU-risk, the method for assessing that risk has not evolved significantly in 20 years. In order to tackle this challenge, ReQbo has developed and patented its Qone system: a pressure relieving mattress, with integrated temperature and pressure mapping sensors, that synchronizes data with a highly accurate screening algorithm. This algorithm assesses a PU risk score based on individual patient parameters and a long-term record of how pressure and temperature have been distributed in the patient’s body, allowing a reduction of approximately 75% on the overall number of new pressure ulcers in bedridden patients. The result of each risk score assessment is communicated wirelessly to the accompanying app and to the hospital monitoring system in order to inform the caretaker that a preventive measure needs to be implemented.

Keywords: pressure ulcers,pressure sores,personalized prevention,intelligent system,bedridden patients,long term care
Resolving spinal cord cell type evolution with single cell sequencing (ScLamprey)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2025-01-08
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The emergence of vertebrates was accompanied by a major increase in nervous system complexity, as a sophisticated brain and spinal cord evolved to process enhanced sensory input and direct co-ordinated motor output. Such complexity is achieved by an increase in cell number, a greater diversity of cell types and sophisticated mechanisms to organise them. Is has long been debated whether the “2R” whole genome duplications, which occurred just before the vertebrate split, contributed to the vertebrate increased complexity. To address this, we will focus on the lamprey spinal cord –a representative of the first branching vertebrates – and relate gene duplication events to the emergence of new neural cell types. Bulk RNA sequencing and developmental studies have started to shed light on neural patterning mechanisms in lamprey, but they do not provide cellular resolution in this complex tissue. This proposal combines traditional molecular methods with cutting-edge single cell mRNA profiling, to explore (1) the cellular diversity of the lamprey spinal cord, (2) the molecular mechanisms that specify those cell types and (3) the evolutionary origins of these mechanisms. First, I will identify marker genes that define specific cell types in lamprey embryonic spinal cord. Second, I will characterise each cell type transcriptional profile at single-cell resolution. Third, I will manipulate pattering signals and assesses the effect on gene expression, particularly on 2R paralogs. Finally, I will compare the lamprey spinal cord to that of other chordates, and relate gene duplication to the evolution of new cell types. This project will generate a cellular atlas of the lamprey spinal cord, which will be the framework for future studies, and shed light onto whether the 2R genome duplications supported the evolution of vertebrate complexity.

Keywords: gene regulation,evolution,vertebrate nervous system,spinal cord,single cell transcriptome
Exploring Visual Processes with Two-Photon Ophthalmoscopy (TrackCycle.2P)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2026-01-31
Duration (months): 72.0
Total project cost (EUR): 1852298.0
EU funding (EUR): 1852298.0
Participants: 1
Project status: SIGNED

In vivo methods to objectively assess retinal physiology are rare among existing imaging techniques. To accelerate the diagnosis of progressive outer retinal disease and the development of treatment before vision is seriously impaired, there is a need for such methods that can quantify visual cycle kinetics in the living eye. Two-photon ophthalmoscopy shows potential to provide new information in this regard paired with microscopic resolution of retinal morphology. The technique can noninvasively track the visual cycle via the transient fluorophore all-trans-retinol in rods and cones separately. In this proposal, we aim to establish two-photon ophthalmoscopy as a method to assess outer retina function and to explore its prospect towards clinical application. An adaptive optics scanning laser ophthalmoscope optimized for safe two-photon imaging in the human eye will be developed. With this instrument, we will quantify the visual cycle in rods versus cones in response to stimulation in healthy human subjects. Particularly the cone visual cycle is not yet fully understood and requires further study. Further, the visual experience of subjects exposed to two-photon ophthalmoscopy will be investigated. The technique uses a pulsed laser as imaging source aimed to evoke nonlinear processes in the retina that can potentially be perceived by the subjects. A detailed understanding of these pathways will provide greater insight into the first steps of vision and help to design suitable stimulus paradigms to test visual cycle function. Successful implementation of two-photon ophthalmoscopy in the human eye promises to deepen our knowledge of normal and abnormal visual cycle function and further our understanding of retinal biochemistry in health and disease.
NESME Inn (NESME Inn)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 22500.0
EU funding (EUR): 18000.0
Participants: 2
Project status: CLOSED

Key account management for Instruments seeking to enhance innovation management capacities in the North East of England

Keywords: enhancing innovation management capacity of smes in the enterprise europe network
Presynaptic calcium channels distribution and impact on coupling at the hippocampal mossy fiber synapse (MF-Synapse)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

This proposal will focus on the hippocampal mossy fiber (MF) synapse, formed between the axons of dentate gyrus granule cells and CA3 pyramidal neurons. The hippocampus plays an important role in learning and memory formation and MF synapses are involved in processing, storage and recall of spatial information. The MF tract connects the entorhinal cortex to CA3 pyramidal neurons. MF presynaptic terminals are large in size, forming giant synapses on proximal dendrites of CA3 pyramidal neurons. Based on this structure, the MF synapse is proposed to have a key role in hippocampal function as a “detonator synapse” that reliably discharges the postsynaptic target neurons. Additionally, it is thought to be involved in storage of information in the CA3 region network by triggering synaptic plasticity between these pyramidal neurons. Despite its important role in hippocampal function and plasticity, there is still very limited information about this key synapse. This proposal will investigate the nanoscale location and distribution of presynaptic voltage-gated calcium channels (VGCCs) at the hippocampal mossy fiber synapse and how it influences coupling at this presynaptic terminal. The opening of VGCCs at presynaptic terminals leads to calcium entry and a subsequent rise in concentration in the vicinity of the channels. The spatial volume occupied by this increased calcium concentration is referred to as calcium domains. The coupling distance between these domains and calcium sensors at the release machinery of docked synaptic vesicles is critical as it determines speed and precision of fusion of vesicles and, thus, release of neurotransmitters. Results from these observations would form the basis for a quantitative understanding of mechanisms underlying time-course of transmission and presynaptic plasticity at this synapse and thus, how it relates to their particular network function in hippocampus.

Keywords: hippocampus,mossy fiber bouton,calcium channel distribution,coupling distance,calcium,microdomain