Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
e-Rescue System: the next level in Post-Accident-Safety. Saving time and lives during the Golden Hour (ERESCUE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Road safety is a major societal issue. Each year around 30,000 people die on the roads of the European Union, i.e. the equivalent of a medium town. Additionally, for every death on Europe's roads there are an estimated 4 permanently disabling injuries such as damage to the brain or spinal cord, 8 serious injuries and 50 minor injuries. Many of the casualties or injured could have been avoided by saving time during the immobilisation and extrication of the victims from the vehicle. In this field of expertise, emergency services speak of the Golden Hour, the estimated maximum time for getting road-accident victims to hospital. After this time, the most seriously injured have very little chance of survival. Additionally, there are experts who estimate that 15% of spinal cord and similar injuries in road accidents are provoked by incorrect immobilisation and extrication of victims. e-Rescue system, like e-Call, has been developed to solve this problem. It is a patented system to be incorporated in the seats of any vehicle which, in case of an accident, prevents unnecessary movement of the patient and it saves precious time for the immobilisation and extrication of the victims. Additionally, the system can be implemented in a cost-effective manner and become a competitive advantage for the EU automotive industry.

Keywords: road safety,golden hour,extrication,automotive industry,emergency,seats
Exploring Laser Interaction with Matters in the Quantum Electrodynamics Regime (ELIQED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-11-16
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

With the next-generation laser facilities at the 10-100 petawatt (PW) level, e.g., the EU-funded Extreme Light Infrastructure (ELI) facilities, the physical picture of relativistic laser-plasma interaction found so far with PW scale lasers may not be valid anymore. It enters a new regime, where at least the following distinct features are expected to appear: 1) Dense electron-positron pairs and high energy γ-photons production via quantum electrodynamics (QED) processes; 2) Significant radiation recoil during electron and positron quiver motion in laser fields; 3) As large relativistic electron mass as proton mass, representing a unique plasma state. To fully exploit and understand this highly complex system, we will investigate some fundamental problems including the propagation of ultra-relativistic laser pulses in plasma, their energy dissipation and allocation to energetic particles and photons, and their scaling to laser and target parameters. Understanding of these problems is essential in order to manipulate QED effects for advanced applications, e.g., generation of high peak flux 10GeV protons, modelling of some energetic astrophysical phenomena, etc. This system is compound with collective and kinetic nonlinearities through wave-wave interactions, wave-particle interactions, and new particle generation and annihilation via QED processes. All these will be treated in a self-consistent way by developing an advanced particle-in-cell (PIC) code with QED processes included. The researcher Wei-Min Wang has nearly 10 years of experience in developing PIC codes for various applications. He was awarded the prestigious IUPAP Young Scientist Award in Computational Physics in 2015. The proposed research and training will further bring the researcher to an independent and matured theoretician. The research achievements will provide significant support to European projects associated with the ELI facilities, which will be ready for experiments in the near future.

Keywords: laser plasma interaction,qed effects,particle in cell simulation
Design, synthesis and biological evaluation of PROteolysis-TArgeting Chimeric (PROTAC) molecules as anticancer agents (PROTACs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-04
End date: 2024-04-03
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: TERMINATED

Cancer diseases are critical medical problems - according to the International Agency for Research on Cancer and European Commission estimates, globally there were more than 18 million new cases and 9.5 million cancer-related deaths in 2018, what indicates that tumors are among the leading causes of death, worldwide. Traditional anticancer drug design based on small molecules continues to be a powerful strategy for the development of novel chemotherapeutics. However, these anticancer therapies are facing major problems such as drug resistance, especially in advanced cancers. This is mainly due to the alterations in the target, ineffective apoptosis or activation of different pathways, among others. The use of PROteolysis-TArgeting Chimerics (PROTACs) has become a promising approach to overcome resistance since they act degrading instead of inhibiting the target, with the advantage of reducing the systemic drug exposure and to counteract the protein expression that often accompanies inhibition of protein function. This approach uses bivalent molecules that possess a target protein recruiting group linked to an E3 ligase interacting moiety for protein degradation. The main goal of this project is to design, synthesize and evaluate a series of new small-molecule PROTACs, which will be able to degrade enzymes and receptors that are responsible for tumor development and progression. To address this aim, I shall carry out a fellowship at Universidad San Pablo CEU under the supervision of Prof. Beatriz de Pascual-Teresa and Irene Ortín from Faculty of Pharmacy. As part of this research, I shall carry out a secondment in the Department of Molecular Biotechnology and Health Sciences at University of Turin (Italy), and another one at the company CsFlowChem S.L. It is worth noting that the design and synthesis of new PROTACs will be based on our wide experience in the development of compounds responsible for inhibition or regulation of the selected target proteins.

Keywords: cancer,anticancer agents,protacs
The role of microbial and invertebrate activities in shaping Alpine Soil Respiration: current state and future scenarios (ALSORES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

The belowground production of CO2 in soil (soil respiration, SR) represents an important terrestrial carbon source. Being correlated with soil temperature, SR is expected to exacerbate climate change. In addition, SR is expected to change considerably and in a patchy manner especially within the Alpine area, reflecting the effects of altitude, land use and climatic conditions. Previous studies measuring SR along altitudinal gradients, however, struggled with strong differences in environmental influences and with distinct unique faunal and microbial communities among samples. The grand ambition of ACTI-RESP is to provide in-depth knowledge and quantitative information on how microbial and invertebrate communities are influenced by altitude, land use and climate change, and on how microbial activity shapes SR. To quantify the pure effect of altitude and to investigate the effects of climate and land use, I will combine field observations and a manipulative experiment within terraXcube, a facility allowing manipulations of multiple conditions including air pressure to mimic different elevations. Thereby, I aim to further test the advantages of studying intracellular DNA (iDNA) as opposed to the generally studied environmental DNA (eDNA). Being composed by considerable amounts of extracellular DNA, eDNA does not only contain information about intact and active cells (intracellular DNA, iDNA) but also about extracellular DNA from species that might not be recently present. Here, I will study microbial agents actually shaping SR by extracting iDNA, by performing qPCR and 16S rRNA sequencing and by comparing the results to eDNA as well as RNA-based results. In doing so, I aim to - define climate change-related alterations in SR - jointly examine soil invertebrates and microorganisms - firstly describe the pure altitude effect on microbial SR, activity and community patterns - test iDNA quantification as a proxy for microbial activity and SR

Keywords: intracellular dna,environmental dna,soil respiration
REfactoring Parallel Heterogeneous Resource-Aware Applications - a Software Engineering Approach (RePhrase)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Israel,Austria,Hungary,United Kingdom,United Kingdom
Call: Tools and Methods for Software Development (H2020-ICT-2014-1, 2014)
Start date: 2015-04-01
End date: 2018-03-31
Duration (months): 36.0
Total project cost (EUR): 3574027.0
EU funding (EUR): 3574027.0
Participants: 9
Project status: CLOSED

The RePhrase project directly meets the challenge of ICT-09-2014, by studying the critically important issue of improving software development practice for parallel data-intensive applications. Data-intensive applications are among the most important and commonly encountered kinds of industrial application, and are increasingly important with the emergence of "big data" problems. Emerging heterogeneous parallel architectures form ideal platforms to exploit the massive-scale inherent parallelism that is usually implicit in such applications, but which is often difficult to extract in practice. Solving this problem will bring major economic benefits to the software industry. To address this challenge, RePhrase brings together a team of leading industrial and academic researchers, software engineers, systems developers, parallelism experts and domain experts from large companies, SMEs and leading universities. It aims to develop a novel software engineering methodology for developing complex, large-scale parallel data-intensive applications, supported by a very high-level programming model. We will exploit advanced pattern-based programming, refactoring, testing, debugging, verification and adaptive-scheduling technologies to build an interoperable tool-chain supporting our methodology, based on but significantly extending existing industrial and research tools. These tools will significantly ease, and even automate, all phases of typical software development, from design and implementation to long-term maintenance and software evolution. The generality of our approach will be ensured by targeting C++ and the most popular low-level parallel programming models, such as the C++11/14/17 standards, pthreads, OpenMP, Intel TBB, OpenCL and CUDA. We will demonstrate our approach on a range of large-scale data-intensive applications, taken from different domains, including bio-medical image processing, data analysis, machine learning, computer vision and railway diagnosis.

Keywords: data intensive applications,parallel patterns,heterogeneous architectures,just in time compilation,dynamic adaptivity,software refactoring,quality assurance analysis,verification
Trusted Apps for open CPS (TAPPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Italy,Germany,Greece,France,France
Call: Smart Cyber-Physical Systems (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3885484.0
EU funding (EUR): 3885484.0
Participants: 11
Project status: CLOSED

Open and smart cyber-physical systems (CPS) are considered to be the next revolution in ICT with enormous economic potential enabling novel business models for integrated services and products. In many areas of CPS devices, there is a strong trend towards open systems, which can be extended during operation instantly adding functionalities on demand. The main goal of the TAPPS (Trusted Apps for open CPS) project is the development of a platform for CPS Apps, which can also access and modify device internals. Therefore, the solution will address all necessary layers from hardware over software to an app store concept always ensuring security and full real-time support for the applications. The extensibility and the pervasive trusted environment of TAPPS are important differentiators that will enable new market extensions to keep pace with user expectations and latest technology. As current, rich execution platforms for apps are limited in security, the project will develop a parallel, real-time Trusted Execution Environment (TEE) for highly-trusted CPS Apps. The TEE is located separately from existing the execution environment inside the System Control Units and exploits functionalities provided by the novel hardware-, processor- and network-centric security mechanisms as well as a hypervisor for virtualization. Furthermore, TAPPS will provide and validate an end-to-end solution for development and deployment of trusted apps, including an App Store and a model-based tool chain for trusted application development including verification tools. This multi-level trusted Apps platform and tool chain are matured and validated in health and automotive application domains using industrial, realistic use cases paving the way for future exploitation in further demanding application domains.

Keywords: trusted app
Large-scale analysis of neuronal population activity (NEUROPOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2023-03-31
Duration (months): 78.0
Total project cost (EUR): 2499131.0
EU funding (EUR): 2499131.0
Participants: 1
Project status: SIGNED

The brain works through the activity of large, spatially distributed neuronal populations. Recent technological advances enable recordings of thousands of neurons from multiple brain structures, offering an unprecedented opportunity to understand neuronal population activity. However, mathematical and computational advances are also required to turn the resulting flood of data into concise principles summarizing brain function. Ideally, these principles would be not just be qualitative, but quantitative: simple formulae that capture the dynamics of neuronal populations, the underlying circuit mechanisms, and their behavioral impact. We will combine large-scale neuronal recording with novel data analysis techniques to study the structure of population activity within and between areas. We will use twelve 960-site probes simultaneously to record from several regions of cortex, hippocampus, thalamus and other structures in awake mice, complemented by recordings combining single high-count probes with wide-field calcium imaging. Optogenetic stimulation of excitatory and inhibitory populations will probe the mechanistic basis of population activity, and experiments in mice performing a discrimination task will probe its effect on behavioral output. We hypothesize that population activity can be quantitatively summarized by a two-level model: first, a low-dimensional dynamical system that captures the macroscopic activity of excitatory and inhibitory populations in each area as a function of brain state; and second, models predicting each neuron’s activity from the interaction of macroscopic variables with specific signals such as sensory inputs. We will validate our models mechanistically by their ability to predict of the effect of optogenetic perturbations on neural firing and behavioral output. The resulting models will form a compact summary of the mechanisms underlying neuronal population activity across multiple brain areas, and their relation to behavior.
Goodmill - Operational Security Through Ensured Connectivity (OpSec)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Finland
Call: Engaging SMEs in security research and development (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-02-01
End date: 2020-01-31
Duration (months): 36.0
Total project cost (EUR): 1939625.0
EU funding (EUR): 1357737.5
Participants: 1
Project status: CLOSED

Goodmill Systems is a global market leader in critical broadbandc onnectivity for vehicles enabling Public Safety and Security (PSS) professionals to utilise mission-critical applications and information on the go. The Goodmill w24e router meets the challenges defined in EC report on the suitability of Commercial Cellular Networks for Mission Critical Broadband, which are reliability, resilience, extensive coverage and price stability. The w24e router utilises commercial networks alongside dedicated networks and wifi to ensure continuous data connectivity. Goodmill is the first in the world to provide seamless and reliable switching between the best available broadband data networks. This ensures uninterrupted connectivity even on moving applications PSS are using increasingly. For the European PSS end user this is a low capex and low opex market-ready solution that provides unparalleled reachability and uninterrupted connectivity to all data crucial for a successful mission. The need for faster data connections will increase and create strain for public administrations to invest into a solution. Traditionally this has meant a new dedicated network that can cost upwards to billions of Euro per EU state. Goodmill router is an alternative that guarantees connectivity now. Through the use of the dedicated networks, commercial networks, WiFi connections, and other routes for data transfer, the availability up to 99.9% can be ensured at all times on the field, depending on the country and available networks. The OpSEC project aims at bringing an updated version of the router to market to answer the challenges in breaking to the North and South America markets. Through technological development and piloting, a successful market entry will be guaranteed and a market share of 20% will be obtained by year 2020 and European standing is obtained on the US-dominated market.

Keywords: multi channel router,public safety and security,availability,connectivity
The evolutionary and developmental origins of Joint Attention: a longitudinal cross-species and cross-cultural comparison (JOINTATT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-07-01
End date: 2022-12-31
Duration (months): 66.0
Total project cost (EUR): 1989611.0
EU funding (EUR): 1989611.0
Participants: 1
Project status: SIGNED

Humans frequently coordinate and share attention about objects and events. Our basic ability to engage in joint attention (JA) is thought to underpin our uniquely complex cooperation skills and language, raising the possibility that the emergence of JA was a ‘small change that made a big difference’ in the evolution of human cognition. Despite the theoretical importance of JA for understanding human social cognition, we know surprisingly little about JA across species and cultures. Methodological shortcomings limit our understanding of the extent to which JA is uniquely human or shared with our primate cousins, and we lack data on how this ability develops in non-western cultures, which aspects of the social environment are necessary for JA to emerge and how JA is related to the emergence of cooperation. The JOINTATT project will address these four key issues by collecting longitudinal data on mother-infant dyads over the first 2 years of the infant’s life, across four different study groups: Ugandan and British humans; wild chimpanzees and crested macaque monkeys. The project will develop novel tasks and measures that allow the same set of data to be collected in directly comparable ways across species and provide the first valid, rigorous test of whether engagement in JA is a uniquely human trait. Data from the two human groups will test how different elements of JA are related and whether JA develops in a uniform way across cultures. Longitudinal data on mother-infant interactions and the infant’s environment will be related to performance on JA tasks across all four groups, enabling us to identify conditions that are likely necessary for JA to emerge. Performance on JA and cooperative tasks will be compared to assess whether engagement in JA predicts the later emergence of cooperation. This project will provide ground-breaking insights into JA and its evolutionary origins, and is likely to challenge current theories of how human social cognition evolved.