Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of amphidial drug uptake in the mode of action and resistance to ivermectin in nematodes of livestock (IDRAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: TERMINATED

The macrocyclic lactones such as ivermectin are the cornerstone for the treatment of key nematode infections of livestock, crops and man. Resistance to many of these broad-spectrum anthelmintics is becoming commonplace, while new classes of active compounds are increasingly difficult to find, threatening food supplies and public heatlh worldwide. The exact molecular and biochemical mechanisms of resistance, particularly to the widely used macrocyclic lactone class, are still poorly understood, impeding the development of efficient strategies to control drug resistance. I hypothesize that the amphidial sensory organs of nematodes are the major route of macrocyclic lactone drug uptake and that mutations in this uptake mechanism represents the primary source of drug resistance. In the first phase of the project, I will develop laboratory methods for testing amphid function in two parasitic nematodes of veterinary significance, the trichostrongyles Haemonchus contortus and Teladorsagia circumcincta. These techniques will be applied on drug resistant and sensitive isolates to evaluate the role of amphids in ivermectin uptake. In the second phase, I will use the C. elegans model to generate mutants resistant to three major classes of anthelmintic drugs, ivermectin, the benzimidazole albendazole and the imidazothiazole levamisole. I will then apply genomic tools to identify alleles responsible of this multi-drug resistance phenotype. This project aims to understand the link between amphid defects, anthelmintic drug uptake, and development of resistance, and will generate a thorough knowledge of this unexplored and apparently widespread resistance mechanism in nematodes. These results will also pave the way to the implementation of a fast and reliable measurement of drug resistance in the field. On the whole, the project will bring a direct contribution to current veterinary and public health challenges by suggesting new strategies to limit the emergence of drug resistance.

Keywords: anthelmintic resistance,ivermectin,nematodes,drug uptake,amphids,macrocyclic lactones,mulit drug resistance,trichostrongyle nematodes
INtelligent solutions 2ward the Development of Railway Energy and Asset Management Systems in Europe (IN2DREAMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Italy,Italy,Italy,Belgium,Greece,Belgium,Slovenia,France,France,France,United Kingdom,United Kingdom
Call: Smart metering and asset management of railway systems (H2020-S2RJU-OC-2017, 2017)
Start date: 2017-09-01
End date: 2019-10-31
Duration (months): 26.0
Total project cost (EUR): 2195715.0
EU funding (EUR): 2195715.0
Participants: 15
Project status: CLOSED

The predicted growth of transport, especially in European railway infrastructures, is expected to introduce a dramatic increase in freight and passenger services by the end of 2050. To support sustainable development of these infrastructures, novel data-driven ICT solutions are required. These will enable monitoring, analysis and exploitation of energy and asset information for the entire railway system including power grid, stations, rolling stock and infrastructure. IN2DREAMS will address these challenges through two distinct work streams: WS1, focusing on the management of energy-related data and WS2, focusing on the management of asset-related data. IN2DREAMS will develop and demonstrate a modular cloud-based open data management platform (ODM) facilitating ubiquitous support of both energy and asset services. WS1 will provide energy metering services through a dynamically reconfigurable platform offering improved reliability, ease of monitoring and on-the-fly optimisation for the entire railway system. This will include a heterogeneous secure and resilient telecommunication platform comprising both wireless and wireline technologies converging energy and telecom services. This infrastructure will interconnect a plethora of monitoring devices and end-users to the railway control centre and will include an ODM platform for data collection, aggregation and analysis, able to scale with the railway operators needs. This platform will be non-intrusive exploiting advanced signal processing and intelligent learning algorithms. Within WS2, IN2DREAMS will concentrate on defining IT solutions and methodologies for business-secure decision support in the field of data processing and analytics for railway asset management. The general aim is to study and proof the application of smart contracts in the railway ecosystems, by addressing also legal and regulatory implications, and advanced visual and rule-based data analytics, including metrics for performance assessment.

Keywords: energy management,asset management,integrated communication platform,sensing devices,monitoring devices,data management platform,smart contract,knowledge extraction,user application
A ground-breaking, nanotechnology sensor-based platform for highly accurate predictive maintenance of industrial equipment. (RetroFeel)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Equipment maintenance is a crucial factor in determining efficiency of industrial plants. Equipment breakage or improper functioning not only impact on product quality and production capability, but also determine huge expenses. Maintenance of industrial plant equipment accounts up to 70% of total production costs, and about 30% of maintenance costs are related to clearly controllable factors, such as improper execution or bad planning of maintenance. In fact, current solutions for industrial equipment monitoring cannot directly measure the status of the single components in the industrial plants (e.g., valves, pipes, pumps, fittings, etc.) and rely on a reactive maintenance approach for fixing or replacing parts after breaking. FeelIT provides RetroFeel, a next-generation platform for analysis, monitoring and predictive maintenance of industrial equipment. RetroFeel is based on nano-sensors that measure the structural integrity of all the single components within the industrial plant in real time, enabling the simultaneous measurement of multiple parameters (e.g. pressure, temperature, humidity, open-close cycles, micro-cracks, leakages, etc) with high accuracy and sensitivity. Data are processed by a proprietary smart analytical software and displayed via a simple user interface to the technician, providing information in real time on the health status and risk of malfunction of all the equipment within the whole industrial line. RetroFeel offers a unique predictive maintenance platform to optimize the maintenance strategies and overall performance by providing the most accurate real-time monitoring of the whole industrial equipment. During the phase 1 feasibility study, FeelIT will establish a sound go-to-market strategy and supply chain, and will outline further development plans. During the innovation project, the Company will optimize the software analytics and sensing system, prepare an in-field test, and obtain certification to commercialize the product.

Keywords: sensors,industrial equipment,predictive maintenance,smart valves,nano sensors,factories,smart analytics
Cofund on Biotechnologies (ERA CoBioTech)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: ERA-NET Cofund
Partnership: ERA CoBioTech (ERA-NET)
Countries involved: Germany,Estonia,Germany,Germany,Germany,Spain,Italy,Israel,Argentina,Germany,Russian Federation,Switzerland,Norway,Belgium,Poland,Slovenia,Türkiye,Romania,Latvia,France,France,Netherlands,Portugal,United Kingdom
Call: ERA-NET Cofund on Biotechnologies (H2020-NMBP-ERA-NET-2016, 2016)
Start date: 2016-12-01
End date: 2022-11-30
Duration (months): 72.0
Total project cost (EUR): 30303030.0
EU funding (EUR): 9999999.24
Participants: 30
Project status: SIGNED

The ERA-Net “Cofund on BioTechnologies” (ERA CoBioTech) aims to better use synergies between current mechanisms of biotechnology research funding in Europe, to highlight the benefits of a bio-based economy for society, and to thus maintain and strengthen Europe’s global lead in modern biotechnology. The co-funded call will focus on application-oriented research in: a) Synthetic biology approaches to design and construct new biological parts, devices and systems b) Systems biology approaches to metabolic engineering and optimisation of biological processes c) Identification and use of the metabolic potentials of genomic data d) Chemical and biotechnological approaches to transform bio-based molecules into molecules with high added value. Bundling three predecessor ERA-Nets in the area of biotechnology, ERA CoBioTech significantly increases public funding (call volume ~ 30 Mio €), intensifies collaboration across relevant sectors and countries, and thus - advances RD&I in industrial biotechnology - establishes systems and synthetic biology as technology drivers in applied biotechnology, and - enhances the potential for exploitation through active industry involvement. Necessary steps and measures to achieve these goals will be encompassed in a joint Strategic Agenda. With a “European Biotechnology Hub”, ERA CoBioTech realises an entirely new concept, reaching out to key actors and stakeholders from multiple biotechnology-related areas in order to align different European strategic instruments with the goals of the KET biotechnology programme under Horizon 2020 and to increase public awareness of biotechnology for industrial uses. ERA CoBioTech will implement additional funding activities without EC co-funding, which will advance RD&I in industrial biotechnology in line with the Strategic Agenda and the outcomes of the "European Biotechnology Hub." ERA CoBioTech thus provides biotechnology stakeholders with tailor-made support regarding information, communication, networking and funding.
APTOS: industrial scale–up of an Advanced tube forming -Process through Thermal Optimization, enabling energy and manufacturing costs Savings (APTOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project aims at the up scaling and industrial exploitation of the APTOS manufacturing process which innovatively combines hydroforming and hot tube gas forming of light-metal tubes of titanium, aluminium and magnesium alloys, enhanced with optimized pre-thermal treatment and temperature gradients respectively. In many forming processes of tubes made by low-formability alloys and/or with complex geometries, about 5 forming stages has to be performed to achieve the final shape, each one requiring the production of different dies and additional pre-heating steps. Within APTOS project, economic and energy savings of the overall manufacturing process (up to 30%) will be achieved by MASPERO, with the suppression of one step in the forming cycle. MASPERO will exploit in APTOS the results of on-going and previous research projects, for accelerating the innovation and market uptake of the APTOS manufacturing process, which will allow producing pieces with increased geometrical complexity. A fully operational up scaled process will be set up in Phase 2, which will lead for future pre-production series. A partnership is already supporting MASPERO in Phase 1 and some additional partners will be identified during Phase 1: Politecnico di Milano, Mechanic Department, with great and long experience in advanced forming processes, Fraunhofer IWU of Chemnitz, with a remarkable experience in hot gas forming, and CiaoTech, an European firm active in Economic services for industry. The potential market of the proposed fully optimized process is enormous as structural and functional shaped light-alloy tubes are used in all kinds of vehicles (bicycles, motorbikes, cars, trains, airplanes, helicopters) and household appliances, kitchenware and other industrial design items, where the lightweight design is a plus. Nowadays, the motorbikes sector is about 19% of Maspero total turnover, automotive 9%, trains 6%, aerospace 2%, kitchenware 3%, with lower percentages for other sectors.

Keywords: advanced tube forming process,hydroforming,hot tube gas forming,complex shape,aluminium magnesium titanium alloys,high strength steels
urbisphere - coupling dynamic cities and climate (urbisphere)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Greece,United Kingdom
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-04-01
End date: 2027-03-31
Duration (months): 84.0
Total project cost (EUR): 12720904.0
EU funding (EUR): 12720904.0
Participants: 4
Project status: SIGNED

urbisphere will change how the scientific community conceptualises, characterizes and forecasts cities in the climate system and in urban planning, by developing a radically new approach to integrate multiple dimensions of urban change, their interaction and feedbacks. It aims to forecast and project urban futures and climates in a dynamic framework considering weather, air quality, differential exposure and vulnerability of people at neighbourhood to city scale. It will provide new insights into existing and emerging risks, based on a synergistic effort across disciplines which currently work mostly in parallel. Urban-Surface Models (USM) and Human Exposure and Vulnerability models (HEV) will be developed and coupled to improve the forecasting of exposure, emissions, and intervention potentials in cities. This will transform emergency/risk management, atmospheric forecasting and long-term urban development/adaptation strategies in the urban sphere. The system will use a real-time 4D Smart Urban Observation System (SmUrObS) to provide targeted urban form/function/emissions/exposure data using novel ground and remote sensing technology. The USM-HEV-SmUrObS system will equip us with: 1) a deep understanding of socio-economic dynamics and human behaviour and responses to weather and climate, economic (and other) drivers that transform cities’ exposure and vulnerability to climate change-related hazards (like heat); 2) a consistent method that can be scaled from detailed high-resolution modelling of intra-neighbourhood scale characteristics, to climate and socio-economic modelling and assessment at city, regional and global scales; 3) an approach that can inform global climate and global vulnerability and risk modelling; will allow consistent downscaling to the city for decision making for local urban risk and resilience management; and provide information on the dynamic nexus of exposure and vulnerability of people in cities.

Keywords: urban climate,dynamic systems modelling,urban surface models,human exposure and vulnerability,smart urban observation systems,energy,water,carbon and air quality exchanges
Dissecting the mechanistic basis of moon-controlled monthly timing mechanisms in marine environments (Mari.Time)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Austria,Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1975000.0
Participants: 2
Project status: SIGNED

The correct timing of biological processes is crucial for organisms. The moon is an important timing cue for numerous marine species, ranging from brown and green algae to corals, worms and fishes. It acts either directly or via the synchronization of monthly (circalunar) inner clocks. Such lunar timing mechanisms typically control the gonadal maturation and behavioral changes associated with reproductive rhythms, including spectacular mass-spawning events. Despite their biological importance, the mechanisms underlying circalunar clocks, as well as their responses to naturalistic stimuli are unknown. My lab has spearheaded research into the mechanisms underlying circalunar timing systems, establishing tools and resources for two well-suited, complementary animal models: Platynereis dumerilii and Clunio marinus. We unraveled first principles of the circalunar clock, e.g. its continuous function in the absence of oscillation of the daily (circadian) clock. Recent unpublished work revealed the first gene that functionally impacts on circalunar rhythms. By capitalizing on these powerful tools and key findings, my lab is in a leading position to dissect the mechanisms of circalunar clocks and their interaction with other rhythms and the environment via three objectives: (1) A reverse genetic approach to unravel how nocturnal light sets the phase of the monthly clock. (2) A forward genetic screen to identify molecules involved in the circalunar clock, an experimental strategy that was the key to unravel the principles of animal circadian clocks. (3) By growing animals in outside tanks and subjecting them to established analyses, we will test our lab-based results in more naturalistic conditions. This project will substantially deepen our mechanistic insight into marine rhythms – ecologically important phenomena – and provide a first basis to predict how environmental changes might impact on timing systems of crucial importance to many marine species and likely beyond.

Keywords: chronobiology,photobiology
Advanced RoBOTic Technology for Handling SOFT Materials in MANufacturing Sectors (SOFTMANBOT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Albania,Germany,Spain,Italy,Italy,France,France
Call: Handling systems for flexible materials (RIA) (H2020-NMBP-FOF-2019, 2019)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 7558651.25
EU funding (EUR): 7558651.25
Participants: 12
Project status: SIGNED

SOFTMANBOT is an industrial-end-user driven project that will provide an innovative and holistic robotic system for the handling of flexible and deformable materials within labour-intensive production processes. The robotic system will be composed by three main pillars including a generic robotic perception system (perception of the product and the human operator), a multi-sensor control and planning platform (advanced control algorithms for shape and contact servoing, AI based task generalization) and smart dexterous grippers (smart mechanical design which will embody grasping/manipulation skills and integrate sensors – mainly tactile – for identifying precisely the contact state between the product and the gripper) able to handle soft components with high-levels of robustness and flexibility. The automation solution is aimed to work in close collaboration with human operators in order to help them in the execution of contact-based challenging tasks so that the productivity and job quality will be boosted which will highly contribute to bring back production to Europe. Special attention will be paid to the integration of novel robotic concepts based on aspects of safety, ergonomics, adaptability, acceptance and user experience. In order to facilitate the assessment of the performance, transferability, scalability and large scale deployment of these solutions, the demonstrations will be conducted under real industrially relevant environments in four pilot demonstrators involving four key manufacturing sectors – toy, textile, footwear and tyre –. The project is not just aiming at quantitative improvements brought by cutting-edge technologies in a specific sector, but to use technology innovation to support a change of paradigm where handling of soft materials with the involvement of robots become a feasible and widespread alternative for European factories, specially SMEs.

Keywords: robotic perception,multi sensor control,smart dexterous grippers,artificial intelligence vision,human robot collaboration,contact based tasks,deformable objects
Encouraging CUlture of REsponsible RoboticS (ECURES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-08-22
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

This project brings a sociological perspective to the field of roboethics and Human-Robot Interaction (HRI). The focus is on robots defined as physically embodied artificial agents, particularly new types of robots such as social robots that are designed in appearance and functionality to communicate with humans and engage them in social interactions. In order to ensure that robotics technologies are beneficial for society it is important to develop frameworks for ethical robot design and responsible robotics. Yet, from the roboticists’ perspective, the existing approaches and initiatives dedicated to ethics in robotics have been considered as largely inadequate as they often cannot be easily translated into the engineering and computer science terms, and implemented into the actual robot design. Thus, the question is how to facilitate integration of ethics into the actual roboticists’ thinking and work. We propose here that one way to achieve such a goal is by fostering the emergence of a ‘culture of responsible robotics’. The aim of the project is to investigate which strategies and measures would need to be undertaken in order to facilitate the emergence of such a culture of responsible robotics, which primarily and ultimately would pertain to the considerations and practices of robot developers and users, but also will need to begin with the HRI research community.

Keywords: roboethics,qualitative sociology,human robot interaction,social robots