Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanisms of cell plasticity in the liver (PlasticLiver)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

The liver can regenerate thanks to a unique cell plasticity in which “terminally differentiated cells” change identity. Hepatocytes, the most abundant cell type sustaining liver metabolism, can transdifferentiate into a completely different cell type to repair the bile duct epithelium, which entails not only a fate switch but also a conversion of epithelial polarity. Despite this regenerative capacity, bile duct diseases present a major clinical challenge, often requiring a liver transplant. Activating and controlling endogenous regenerative programs, which preliminary data suggest are liver region-specific, is thus a promising therapeutic strategy but requires a deeper understanding of the underlying mechanisms. Based on regional differences in the quality of regenerated bile ducts in a mouse model of Alagille syndrome, I hypothesize that bile ducts in the hilar region regenerate via cholangiocyte proliferation, yielding well-formed epithelia, while bile ducts at the organ periphery develop de novo via hepatocyte transdifferentiation, yielding malformed bile ducts with aberrant polarity. Because there are multiple cell sources for liver repair, PlasticLiver aims to account for spatial and within-cell type heterogeneity in the liver during bile duct regeneration. Taking advantage of a novel cutting-edge approach for high resolution barcode lineage tracing and gene expression profiling co-developed in my host lab, I will resolve region-specific cell sources and mechanisms in developing and regenerating livers of a mouse model of Alagille syndrome. Moreover, combining generated single cell gene expression data and microscopy analysis of healthy and regenerated tissues, I will identify molecular mechanisms and potential targets to improve epithelial polarity in regenerated peripheral bile ducts. Ultimately, PlasticLiver will yield fundamental mechanistic insights into cell fate decisions and why liver, but no other organs, uses this type of cellular plasticity.

Keywords: single cell high resolution lineage tracing
Right to Housing: The Production of Spaces of Everyday Life in Yugoslavia (1945-1991) (Housing. Yu)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: Croatia
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 2370438.0
EU funding (EUR): 2370438.0
Participants: 1
Project status: SIGNED

Housing.Yu researches the production of spaces of everyday life in Yugoslavia (1945–1991), which still constitutes about 60–70% of the current housing stock of Bosnia and Herzegovina, Croatia, Macedonia, Montenegro, Serbia, and Slovenia. The project will employ a comprehensive, interdisciplinary, and methodologically innovative approach to the government’s actions, urban planners, architects, contractors, and citizen-users. The project aims to understand the critical phenomena of mass housing in a socialist state, including its policies, estate development, citizen participation and related knowledge exchange between Western and Eastern Europe. Housing policies were an essential part of the development of the self-management of socialist Yugoslavia, in which the workers decided on housing. Yugoslavia carried out three political-economic and housing reforms with an aim to generate legislation and implementation, as well as material and professional frameworks for mass housing, experimenting with different forms of standards, financing, organization of production, and ownership. In these overlapping processes, it relied on the inherited pre-war and then-contemporary practices from the East and the West, mediated by dynamic knowledge exchanges. Investigating the housing production through the relationship among social processes, construction and knowledge exchange, project transcends the traditional field of art history by using digital tools. It valorizes the housing project of socialist Yugoslavia and its contribution to the Pan-European Project Homes for all People, which ended with Right-to-buy. Housing.Yu will generate a valuable, open-access repository of knowledge of interest to the scientific, educational and professional community, both in the countries where it is implemented and at the European level. The project’s results warrant a social impact at a time when Europe is facing yet another housing crisis and broader social and environmental challenges.

Keywords: housing estates development,citizen participation,housing policies,knowledge exchange
DNA-based Infrastructure for Storage and Computation (DISCO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Ireland,Germany,France
Call: EIC Pathfinder Challenge: DNA-based digital data storage (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 3993665.0
EU funding (EUR): 3993665.0
Participants: 3
Project status: SIGNED

Throughout evolution, Biology has found an almost-perfect molecule to pass information down through the millennia. Whether for a simple bacterium or the largest whale, DNA achieves high information density while permitting cellular machinery rapid random-access retrieval to decode everything from a single protein to the development of an entire human brain. Humanity's rapidly-growing data storage and computing needs make it is tempting to exploit optimised biological molecules and processes, but biology is messy, poorly-understood and much more specialised for life than it is for our needs -- we propose to use DNA for storage together with a rationally designed, well-characterised and robust molecular computing architecture. The DISCO project will address the challenge of engineering a programmable and robust DNA storage and computing platform. DISCO combines powerful molecular-algorithmic ideas from DNA computing with notions of thermodynamic stability from DNA nanostructures, to provide an expressive and robust system design. The project proposes the use of long DNA scaffold strands, upon which hundreds of smaller strands bind to store data, which can be later read, erased, rewritten and computed upon. DISCO begins with the aim of trialing a small, but thoroughly characterised and modelled prototype, that facilitates storage and computation on 10 bits. Then, DISCO will scale-up the system to hundreds of bits by leveraging recent technological advances to enable high-throughput techniques at both the experimental and data-readout stages. Finally, DISCO will be extended to two-dimensional DNA origami structures, each carrying about a hundred bits, but with millions of structures in the same test tube, exhibiting DNA storage and computation in a distributed system at a massively parallel scale.

Keywords: dna computing,dna storage,dna nanotechnolgy
Hyperoxic MRI of Perivascular Spaces (HERMES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 172874.24
EU funding (EUR): 172874.24
Participants: 1
Project status: TERMINATED

HERMES aims to develop more effective strategies that increase our understanding of the brain in health and disease. The ability of magnetic resonance imaging (MRI) to study brain fluids noninvasively offers a unique opportunity for revealing how cerebrospinal fluid promotes waste clearance from the brain. Perivascular spaces are key structures involved in this process. They are gaps surrounding small blood vessels along which cerebrospinal fluid can move. A comprehensive understanding of the anatomy and function of perivascular spaces is lacking, but it could ultimately uncover important mechanisms of brain disease and lead to novel treatments harnessing cerebrospinal fluid movement for drug delivery to the brain. Building on my expertise in structural MRI and my proposed supervisor’s expertise in functional MRI coupled with supplemental gas inhalation, I will use MRI to track oxygen movements in brain fluids, thus developing inhaled oxygen as an image contrast agent for perivascular spaces. I will characterise the anatomy and function of perivascular spaces in a healthy population from 20 to 60 years old. Then, leveraging my proposed clinical co-supervisor’s expertise in neuroinflammation, I will investigate the role of impaired perivascular space function in multiple sclerosis, the leading cause of neurological disability among young and middle-aged adults, affecting more than 700,000 people in Europe. During this fellowship, I will deepen my scientific expertise by learning how to conduct MRI experiments with multiple image contrasts and supplemental oxygen. The training provided by my supervisors, the scientific and transferable skills provided by the fellowship and the excellence of the host institution will all be essential to deliver the goals of this project. Ultimately, HERMES will help me to establish my own research group and create a long-term impact by sharing my expertise with academic and industrial partners.

Keywords: magnetic resonance imaging cerebrospinal fluid perivascular spaces multiple sclerosis gas challenge brain neurological disease functional mri
Healthier diets and sustainable food and feed systems through employing microbiomes for soya production and further use (MICROBIOMES4SOY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Austria,Netherlands,Ireland,Iceland,Belgium,Italy,Canada,United States,France,Germany,Spain
Call: Microbiomes in food production systems (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 5633542.5
EU funding (EUR): 5523171.0
Participants: 20
Project status: SIGNED

Animal-based proteins constitute a significant ingredient in European food systems. Dependence on animal-based proteins comes with substantial environmental and health impacts. Hence, the transition toward plant protein-based food systems is now more critical than ever. MICROBIOMES4SOY is an interdisciplinary and intersectoral project that employs a Multi-Actor Approach to ensure that food system actors' needs and key components relevant to the FOOD 2030 priorities are addressed. MICROBIOMES4SOY aims to enable transition pathways by delivering a comprehensive understanding of the microbiomes along the food and feed chains. Exploiting the microbiomes' full potential is essential to ensure sustainable and nutritious food and feed as they are important players throughout the food system, ranging from primary production, where microbes improve plant growth and health, to food production based on microbial processes and ultimately linking to the interactions between animal/human microbiomes and host health. MICROBIOMES4SOY focuses on the soya bean model system, an important protein-rich crop. The project will develop second-generation microbiome applications that sustain crop productivity and improve soya bean seeds' nutritional value and safety under different environmental conditions. MICROBIOMES4SOY will test the effect of dietary intervention based on soya bean-derived protein on the human gut microbiome and health and elaborate microbiome-informed dietary recommendations. The project will also employ microbiome-based solutions to develop novel aquafeeds and establish their effects on the fish gut microbiome and health. MICROBIOMES4SOY consortium comprises 19 partners from 11 countries contributing complementary expertise on soil, plant, human and animal microbiomes, bioinformatics, modelling, crop production, aquaculture, food/feed production, food systems mapping and scientific communication.

Keywords: microbiome,soya,food system,protein,health,feed
Dissect cargo selectivity in autophagy (AUTO-SELECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1993750.0
EU funding (EUR): 1993750.0
Participants: 4
Project status: SIGNED

(Macro)autophagy is an evolutionarily conserved catabolic process induced to preserve cellular homeostasis under conditions of stress, such as nutrient starvation. Upon autophagy activation cellular components are engulfed by autophagic vesicles, which then fuse with lysosomes for substrate degradation. Despite the unquestionable physiological and medical relevance of nutrient- and pharmacological-induction of autophagy in human health, the precise identity of autophagy substrates and the rules governing their selection in vivo are largely unknown. AUTO-SELECT’s goal is to provide a framework to identify physiologically relevant autophagy substrates in different organs and to determine the signaling events that govern their selection. This proposal relies on (1) newly generated mouse models to genetically manipulate autophagy and key autophagy regulators, (2) tools to quantitatively measure autophagy substrate delivery to lysosomes and subsequent degradation in vivo, and (3) -omic technologies and bioinformatic tools to dissect the molecular events that govern substrate selection in response to diverse stimulations in a tissue-specific manner. In addition, AUTO-SELECT will develop new strategies to modulate selective autophagy and test their therapeutic relevance in connective tissue disorders characterized by the intracellular accumulation of misfolded procollagen molecules. AUTO-SELECT has the potential to discover new rules governing cargo selectivity during autophagy and, hence, to provide new links between energy metabolism and cellular quality control that might be exploited for autophagy modulation to treat human diseases.

Keywords: autophagy,selective autophagy,lysosome,nutrient sensing,mtor
Making access to the ocean affordable through our SeaSprings mooring solution (TfI SeaSprings)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 3465620.5
EU funding (EUR): 2425934.35
Participants: 1
Project status: SIGNED

TfI SeaSprings is a novel mooring solution for floating offshore structures, e.g. floating offshore wind turbines (FOWTs). State-of-the-art mooring systems mainly approach the complex offshore mooring challenge by increasing the system's strength. Our patent-pending TfI SeaSprings innovation changes mooring system response to reduce peak loads by ~50% and wear and tear by ~30%. As a result, mooring systems can be significantly lighter, their lifespan can be extended, and it allows use of smaller deployment vessels with greater availability and a reduction of ~€170k/day on vessel hire. These factors all lower CapEx and OpEx, which can support FOWTs in reaching target levelised cost of energy (LCOE) of €90/MWh from €160/MWh. This makes SeaSprings a very attractive solution to FOWT developers and energy consumers. The smaller footprint, lighter chains and use of a semi-taut rather than catenary system, reduces environmental impact and crucially opens up new locations for deployment.

Keywords: environmental protection,sustainability,carbon footprint,lcoe,offshore energy,floating offshore wind turbines,aquaculture,ocean resources
Advancing knowldge for Long-term Benefits and climate Adaptation ThRough hOlistic climate Services and nature-based Solutions (ALBATROSS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Italy,Belgium,Germany,South Africa,Ghana,Kenya,Tanzania, United Republic of,Madagascar,Finland,France,Slovakia,Spain,Switzerland
Call: Needs-based adaptation to climate change in Africa (HORIZON-CL5-2023-D1-01, 2023)
Start date: 2024-03-01
End date: 2027-08-31
Duration (months): 42.0
Total project cost (EUR): 5031896.25
EU funding (EUR): 4999646.25
Participants: 18
Project status: SIGNED

Increasing vulnerability due to climate change requires cross-sectoral management of the territories with bottom-up approaches based on active community participation. Climate change intensifies territorial risk and impacts severely on human migration and displacement, particularly in sub-Saharan Africa. Avoiding maladaptation associated to internal migration as well as to other adaptation actions which do not adopt a nexus approach (e.g. water-food-energy nexus) requires effective planning and management of migration hot spots. At the same time, it calls for more integrated strategies which simultaneously support sustainable development growth pathways and climate resilience development in the African context. ALBATROSS aims at addressing these challenges by delivering novel, innovative and decision making-relevant tools and knowledge which will support the adoption of feasible, effective, and sustainable need-based adaptation strategies into AF policies and programs. It will do that by co-creating climate services and tools which will enable the weighting of compound and cascading impacts (benefits and threats) on ecosystem health, food security, socio-economic vulnerability while addressing specific natural hazards (e.g., drought or flood) or sectoral climate adaptation needs (e.g., agriculture) through nature-based solutions (NBS) and other climate adaptation measures. The methodological approach of ALBATROSS will be tested ad validated in different Sub-Saharan countries, leading to the co-creation and co-evaluation with key stakeholders of need-based adaptions options and plans. By combining participatory approaches with fundamental research grounded on the latest generation of observational data and modelling techniques, ALBATROSS will provide robust and science-based evidence on the degree at which NBS may perform as multifunctional adaptation strategy for counteracting forced migration, biodiversity loss and hydrometeorological risk in Sub-Saharan Africa.

Keywords: community driven climate services climate adaptation policies nature based solutions indigenous knowledge stakeholders engagement
Integration of innovative and reliable socio-ecological models and user-driven solutions into the Digital Twin Ocean, to facilitate what-if scenarios and decision support, under a co-creation approach (SURIMI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Research and Innovation actions
Countries involved: Norway,Spain,Belgium,Greece,Italy,Ireland,United Kingdom
Call: Integration of socio-ecological models into the Digital Twin Ocean (HORIZON-MISS-2023-OCEAN-01, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 3026332.5
EU funding (EUR): 3026332.5
Participants: 8
Project status: SIGNED

SURIMI’s overall objective is to develop social-ecological models and user-friendly solutions that will be integrated in an interoperable and standardized manner within the DTO to generate policy analysis rooted in management strategy evaluation (MSE) principles. The project will develop the SURIMI toolbox which will 1) provide open-source interchangeable socio-ecological, assessment and policy models including protocols and standards for model and data interoperability, 2) ensure the collection and harmonization of data informing these models across EU waters as well as ensuring long-term accessibility of the data and 3) package models, data and a visualization interface with a set of accessible and informative user-centric decision support tools, including the use of natural language processing (NLP) artificial intelligence for policy analysis and implementing a MSE framework to thoroughly account for benefits and costs of policy implementations. The project will integrate every element of the SURIMI toolbox (models, data, interoperability layer, graphical user interfaces) as core elements of the DTO infrastructure and model lab. SURIMI will cover and generalize broadly across the EU waters while providing input interfaces for users to tailor scenarios to their specific use-cases and local twins by inputting their own data and assumptions. Throughout the entire project lifetime, SURIMI will engage a wide community of stakeholders from research, industry, advocacy, policy and society, to co-create, co-design and co-assess the SURIMI toolbox in a demand-driven and responsive development cycle. All this, 1) expanding the DTO to covering ecology, economy and society and thus complementing its capacities and uses, 2) enabling better management of human activities, 3) facilitating what-if scenario analysis, decision support, and policy implementation both at European and regional/local scales, and 4) contributing to the EU Mission Ocean Restore our Ocean and.

Keywords: co creation,community building,user centric interfaces,management strategy evaluation,decision support,nlp,socio ecological modelling,what if simulation,data interoperability,dto integration