Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Flow and Iron for Pharma (FI4P)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-16
End date: 2022-05-17
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

The demand for sustainable methods to build chemical bonds has led to the rise of catalytic reactions, especially using abundant and benign metals. In this context, iron has emerged as a powerful catalyst to mediate various transformations including cross-couplings between (pseudo)halide electrophilic partners and organometallic nucleophiles, usually Grignard reagents. We aim to develop a modular and versatile Flow-enabled Iron-catalysed cross-coupling protocol for Pharmaceutical applications (FI4P), leveraging the unique properties of flow chemistry to implement cross-couplings between organolithium derivatives and electrophiles. Building on the significant expertise of the academic host in this field, we will seek to harness flow technology to exert spatiotemporal control over reactive intermediates, thus ensuring the functionalisation of halide precursors with reactive lithium organyls generated in situ. The particularly high reaction rates observed in iron-catalysed cross-couplings will allow the incorporation of valuable functional groups usually incompatible with organolithium derivatives. This approach will deliver a sustainable method to assemble relevant molecular scaffolds of interest to the pharmaceutical industry. With the involvement of NovAliX, an industrial partner specialised in transferring academic innovations into industrial processes, we will eventually apply our synthetic protocol to the large-scale manufacture of valuable APIs and the generation of a small collection of molecules designed to complement our existing library for Fragment Based Drug Design.

Keywords: flow chemistry
Autonomous Infrastructure Inspection via Vortex Robot Climbers (VORTEX)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Sweden
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-06-01
End date: 2022-11-30
Duration (months): 18.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: SIGNED

Existing EU policies aiming on strengthening and growth are mainly focused on new developments, omitting investments in inspection and maintenance operations due to traditionally high costs. To overtake this, VORTEX aims to commercialize the Vortex Robot (VR) technology developed in Η2020 FETOPEN CompInnova, which will increase the inspection efficiency in terms of lower execution times, lower operational costs and higher worker safety. VORTEX will focus on the creation of its brand name and expand the dissemination/communication activities implemented in CompInnova to focused industrial events and wider media/press channels, for maximizing societal and market acceptance of autonomous multi-robot systems tackling inspection and maintenance tasks. VORTEX will use as the base the identified aerospace maintenance market and the end-users/customer base formed during CompInnova from within the aerospace industry, to expand on potential stakeholders and customers in wider inspection and maintenance areas. Through the implementation of a commercialization plan, analysis of potential markets, technology assessment and consolidation of intellectual property rights, the envisioned activities will lead to the development of the VORTEX business case. The planned dissemination and exploitation activities will stimulate the formation of an open and proactive mindset towards exploiting innovative tools in infrastructure inspection and maintenance, which are beyond the technical capabilities of existing companies, for addressing the demands for higher human safety and reduced downtime costs.

Keywords: climbing robots,autonomous inspection,collaborative robotics
Combining wood and polymers to produce a translucent, reinforced and ecological material (POLYWOOD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: France
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 79375.0
EU funding (EUR): 79375.0
Participants: 1
Project status: CLOSED

The project POLYWOOD (Combining wood and polymers to produce a translucent, reinforced and ecological material) is mono-partner, lead by French startup WOODOO, and responds to the call topic “Coordination and support actions, H2020 SME Innovation Associate”. WOODOO has developed a breakthrough patented technology, focusing on wood modification at the cellular and molecular scale. It starts from native wood, removing lignin and impregnating the cellulosis matrix with selected monomers, polymerizing in situ to create much stronger bonds between the wood native fibers. The result is a translucent wood, three times stiffer than natural wood, much more durable, water and fire resistant. Research has been done before on de-lignification and on the monomeric impregnation of wood, but never have they been combined in the way WOODOO does, with a direct and highly promising application potential across various industries. The industrial development of this process could establish Europe as a world leader on the market of bio-based materials. In alignment with the new EU forest strategy (EC, 2013), WOODOO will help unfold the potential of the European forest. This bio-based, low-carbon material will help tackle the urgent need of lowering the carbon footprint in the building industry. WOODOO offers a 12 month position to a European material science researcher, with a strong knowledge of functional monomers, wood structure, and industrial processes, in order to reach its next objective: bringing the technology from the lab to the market. The research associate will take full advantage of WOODOO international team, as well a use an occasion to show polyvalence, leadership and commitment in the exciting environment of a booming startup, awarded with multiple innovation awards. The POLYWOOD total grant request to the EC is 79 375 € and the total eligible project budget is of equal amount. The project will be conducted over 12 months in close alignment with the overall WOODOO needs

Keywords: translucent and reinforced wood,functional polymers,bio based materials,ecological material,lignin
Origin: Development of a compact, time efficient and safe medical diagnostic machine (Origin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Current tissue processors on the market take up to 24 hours to process samples for diagnosis and leave the operator exposed to chemical fumes. They also use different kinds of chemicals, in large volumes, which leads to cross contamination of chemicals and samples. This results in more plastic packaging to dispose of, making the process both costly and environmental unfriendly. Our company, DIAPATH SpA, is developing an innovative solution to these problems - the E-Processor. DIAPATH has been in the tissue processing industry since 1997 and currently has a turnover of €12Million and 100 employees. The E-Processor reduces the number of processing steps, and reduces the number of chemicals used. The operator will be safeguarded from chemical fumes and chemical containers will now be disposed of in a safe and environmentally friendly way. Our value proposition is, less operating costs due to reduced chemicals and packaging, faster diagnosis and results for patients. Our target users are Hospitals and Diagnostics Laboratories. The current global diagnostics market is estimated at €243.59 Million and expected to reach €378 Million by year 2025. Our entry point for our innovation will be the European market, where we already have significant market share. We will be using our extensive distribution chain to bring our innovation to international markets. Our innovation is currently at prototype stage with a compact functional machine. Further validation and tests remain to be done to bring it to market. The purpose of the phase 1 is to carry out feasibility studies before commercialisation. This will allow us to come up with a detailed business plan covering a projected five-year period. This innovation will grow our market share from 30% and increase our turnover to €50million by 2023. It will also create 15 new jobs.

Keywords: cancer diagnostics,tissue processor,diagnostic machine,histopathology,laboratory diagnostics,human tissue,tissue fixative,pathology
Search for light Dark Matter with a Spherical Proportional Counter (DarkSphere)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The aim of DarkSphere is to shine a light on the nature of Dark Matter (DM), with the NEWS-G direct detection experiment that focuses in the low mass region. Through the novel detector concept of Spherical Proportional Counters, the experiment will provide for the first time access to the 0.1 - 10 GeV mass region, which is highly motivated by the Higgs boson discovery and the non-observation of supersymmetry at the CERN Large Hadron Collider. The innovative detector concept offers a number of advantages, including: very low energy detection threshold, background rejection capabilities, and construction of large volume using solely radiopure materials. Furthermore, in contrast to other direct detection experiments, using a choice of light target gases, including hydrogen, helium, and neon, allows the NEWS-G experiment to kinematically match the target to the DM candidate mass, and thus maximise its sensitivity for each mass in the region of interest. Within the project a number of advances will be achieved in terms of detector optimisation and simulation through original measurements, background measurement methods, physics analysis with novel classification and statistical inference methods, and advances in DM phenomenology. Beyond use in fundamental physics research, the detector concepts relevant for DarkSphere have potential for industrial and medical applications, which are also explored.

Keywords: dark matter direct detection,gaseous detectors,spherical proportional counter,fast neutron spectroscopy
Degradable Polyolefin Materials Enabled by Catalytic Methods (DEEPCAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2494829.0
EU funding (EUR): 2494829.0
Participants: 1
Project status: SIGNED

Plastics are essential to virtually any modern technology and therefore ubiquitious. However, when released to the environment they can persist for centuries. One pillar of a responsible future economy is therefore to endow important plastics with a non-persistent nature. Polyethylene (PE) is the largest scale synthetic material, used in transportation, energy storage, water cleaning, clothing and many other fields. However, it is most problematic concerning degradability. This proposal addresses this major challenge by introducing photo- and hydrolytically degradable groups in the PE chain. Directly during catalytic PE synthesis, isolated keto groups will be generated by incorporation of small amounts of carbon monoxide. This yet unachieved goal is targeted via catalysts with extreme shielding and rigid ligand environments in heterobimetallic Ni(II) / main group metal complexes. A compartmentalized aqueous polymerization with precise control of high ethylene/CO ratios will yield the in-chain functionalized PE as nano- and microscale particle dispersions. Living catalytic polymerization in nanoparticles is pursued to achieve ultra high molecular weights and gradient PE chains forming nanodomains varying in ketone density. Aqueous heterophase oxidation with benign oxidants on all these nanoparticle will yield in-chain ester groups. Further types of hydrolytically cleavable groups are targeted via the complementary synthetic approach of step growth from seed- or microalgae-oil derived PE-telechelics. This yields linear PE with in-chain carbonate, acetal and anhydride groups. Basic materials properties of all polymers are determined by tensile tests. Degradation studies reflecting a marine environment will indicate the persistency behaviour and fate of microfragments, using macroscopic specimens and the above particles as models. Knowledge of the particle and bulk morphologies will be instrumental to understand the materials and degradation properties.

Keywords: polymerization catalysis,renewable feedstocks,sustainable polymers,functionalized polyethylene,organometallic mechanisms,polyethylene like materials,long chain polyesters
Quantitative Surgical Guidance for Colorectal Surgery using Endogenous Molecular Contrast (QuantSURG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland,France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2024-01-31
Duration (months): 84.0
Total project cost (EUR): 1584250.0
EU funding (EUR): 418827.85
Participants: 2
Project status: SIGNED

Despite significant advances in medical imaging technologies, there currently exist no tools to effectively assist healthcare professionals during colorectal surgery. Surgeons mainly rely on their own senses, vision and touch to identify diseased tissue that should be removed or healthy tissue that should be avoided. In turn, surgery remains subjective and dependent on the experience of the surgeon, resulting in unacceptable failure, recurrence and morbidity rates, as well as in significant quality of care disparities across hospitals. The hypothesis underlying our study is that near-infrared light travels deeply into living tissues and interacts with endogenous molecular constituents, namely oxy- and deoxy-hemoglobin, water and lipids, providing key information regarding tissue perfusion, oxygenation, hydration and metabolism. In turn, such information can be used to differentiate diseased from healthy tissue. We recently introduced a novel concept that enables the quantitative imaging of endogenous molecular information over large fields-of-view. Because this concept can be implemented in real-time, it is amenable to provide video-rate endogenous information during colorectal surgery. In this study, we propose to push the limits of this concept by developing ground-breaking theory & technology, and creating a novel surgical guidance device capable of real-time imaging of key endogenous information for colorectal surgery. Correlation between endogenous contrast measurements and histological tissue status will be investigated onto bowel ischemia and colorectal cancer animal models. Finally, a clinically-compatible imaging device will be fabricated and translated into a first-in-human study in patients undergoing colorectal surgery. If successful, this study has the potential to solve a longstanding clinical problem by providing real-time objective feedback during colorectal surgery.

Keywords: image guided surgery,endogenous molecular contrast,diffuse optical imaging,cancer margin,detection,ischemia imaging,colorectal surgery,clinical translation
Seed mucilage envelope as a new structural model in cell wall research (MuCellWall)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The plant cell wall is dynamic, complexes structure composed of polysaccharides divided into fibrillar (cellulosic) fraction and extracellular matrix (hemicelluloses and pectins). All the components are arranged in a network structure characteristic of the cell wall. The proposed, general spatial models of the cell wall based mostly on various biochemical and/or microstructural analysis, which have usually been invasive by treatment with enzymes or chemicals, which can destroy the cell wall organization and allow to visualize a selected components. Despite of extensive research our knowledge about the cell wall is still incomplete and restricted mostly to the biochemical or genetic studies. The main aim of this project will be the determination of the cell wall components i.e. polysaccharides, glycoproteins, and the determination their spatial distribution in a special type of cell wall of the mucilage secreting cells (MSCs). The obtained results will allow creation a direct spatial cell wall model. The used material e.g. seeds of Arabidopsis thaliana mutants and wild type, Artemisia leucodens or Lepidium sativum will be an excellent and so far not examined study model due to characteristic loose spatial structure of the MSC cell wall. The use of modern techniques (in a quite new combinations) e.g. antibodies with attached gold particles and precise visualization in divers microscopes (e.g. SEM, LCSM) available at the host laboratory (Kiel University) will allow to overcome invasive procedures and let to detect the exactly location of the components. The realistic, representative cell wall spatial model will be created allowing for better understanding the different processes taking place within the cell wall. The project will be implemented at an interdisciplinary level opening a new possibilities for various cell wall studies. The project will give a new insight into the cell wall structural studies and lead to significant advances in this field.

Keywords: arabidopsis thaliana,cell wall,mucilage,cellulose,pectins,hemicelluloses,seeds,cell wall model
Take control! Towards novel training regimes enhancing inhibition and impulse control in health and psychiatric disease (Self-Control)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-08-01
End date: 2022-01-31
Duration (months): 66.0
Total project cost (EUR): 1498625.0
EU funding (EUR): 1498625.0
Participants: 1
Project status: SIGNED

Self-control is at the heart of human nature and enables us to resist temptations. Several clinical disorders are characterized by an inability to control oneself, e.g. addiction and other impulse-related disorders. Since these psychiatric diseases are highly debilitating and cause substantial economic costs, any means of enhancing self-control is of high value for society at large. To date the view prevails that inhibition and therewith self-control is untrainable. Contrary to this, the applicant has gathered data demonstrating that healthy older participants can be trained in inhibition using a game-like self-control training. Trained participants showed transfer to an untrained inhibition task and brain structural plasticity in right inferior frontal gyrus, a brain region associated with inhibition of prepotent actions. The main goal of this research program is, to develop and optimize this promising self-control training and investigate its effectiveness in real-life self-regulation problems in the healthy population (dieting and quitting to smoke) as well as in patients suffering from alcohol addiction. The expected impact of this innovative research program is high. Its results will be ground-breaking for basic science as well as for the treatment of patients with alcohol addiction. The final outcome of this project is going to be a freely distributed app encompassing the optimized self-control training, adaptable to the temptations that the trainee wants to gain control about, and therewith enable the general population to counteract self-regulation problems. Since self-control has sparked the interest of multiple disciplines, that have unfortunately so far developed their concepts fairly independently, the results of this research proposal will pave the way to integrate the knowledge gained from experimental, clinical, and social psychology. But most importantly, this self-control training will enable everyone to improve their capacity for self-regulation.

Keywords: self control,self regulation,inhibition,brain plasticity,training,neuroimaging,addiction