Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Regional Ecosystems FOR Multiple-Energy Resilient Systems (REFORMERS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Belgium,Netherlands,Austria,Greece,Spain,Poland,Sweden,Italy,Germany,Switzerland
Call: Renewable Energy Valleys to increase energy security while accelerating the green transition in Europe (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 23207069.0
EU funding (EUR): 19649625.13
Participants: 29
Project status: SIGNED

The EU energy system strongly relies on centralised electricity generation and on fuel imports, with 95% of its oil and 84% of its gas consumption sourced from outside the EU. The REPowerEU Plan proposes a set of actions to reduce the EU’s dependence on fossil fuels and diversify its energy supply ‘well before 2030’. The three pillars of the plan are to ramp up the production of green energy, diversify our energy supplies, and reduce our demand for fossil gas, coal and oil. Renewable energy valleys are understood as decentralised renewable energy systems that offer a viable and efficient solution to these challenges mentioned above. By implementing a high degree of renewable energy sources as well as storage technologies and intelligent management algorithms for synergetic use of a wide variety of technologies, they can be 100% self-sufficient on a yearly basis. For the next 5 years, the REFORMERS project aims to develop, implement an exploit such an energy valley in the Boekelermeer next to the city of Alkmaar in the Netherlands, that serves as a living lab for testing and validating technologies, business models, stakeholder ecosystems, including industrial partners, DSO, the municipality, and residents, and user acceptance in real-life circumstances, in a peri-urban and industrial environment. Furthermore, the project aims to support the deployment of multiple self-sufficient energy valleys throughout Europe beyond the flagship in the Netherlands. Therefore, it will deliver a roll-out blue print and replication toolbox that encompass: (i) Energy System Design, (ii) Environmental Impact Assessment, (iii), Stakeholder Engagement and Social impact assessment, (iv) Governance and policy assessment, and (v) Business modelling, and allow other sites and regions to develop a pathway towards a carbon neutral and self-sufficient energy valley, that can be fed into e.g., a Sustainable Energy and Climate Action Plan.

Keywords: renewable energies energy system integration citizen science energy communities energy valleys
Developing RNA-editing based therapy for renal cystic ciliopathies (KidneyGenRx)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Chronic Kidney Disease (CKD) is a significant global health burden, affecting approximately 10% of the adult population worldwide. It is estimated that 10-20% of advanced CKD cases are caused by genetic kidney diseases, with renal cystic ciliopathies being the most common genetic contributors. In the Israeli Druze population, we have identified a novel homozygous mutation in the WDR19 gene as the leading cause of end-stage kidney disease (ESKD), particularly leading to renal failure in young adults. Currently, kidney failure caused by renal cystic ciliopathies can only be treated through renal replacement therapies, such as dialysis or transplantation, as no specific therapeutic interventions are available. This project aims to establish proof of concept that RNA editing can serve as a viable therapeutic strategy for genetically driven kidney failure. By employing Site-Directed RNA Editing (SDRE) through the action of Adenosine Deaminase Acting on RNA (ADAR) enzymes, we aim to correct the pathogenic WDR19 mutation (c.878G>A) at the RNA level. Our efforts will focus on optimizing guide RNA (gRNA) design and improving delivery mechanisms to maximize editing efficiency and therapeutic outcomes. The efficacy of this approach will be evaluated by its ability to rescue the disease phenotype in patient-derived induced pluripotent stem cell (iPSC)-derived kidney organoids and further validated in murine models. If successful, this proof-of-concept project could pave the way for RNA editing-based therapies as a transformative treatment for genetic kidney diseases.
Starting Grant (PriME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499892.0
EU funding (EUR): 1499892.0
Participants: 1
Project status: SIGNED

Efficient anticancer immune effects are a prime medical discovery of this century. Molecular alarms drive such immune responses, signaling priming and effector cells to action. Several approaches are studied or clinically used to initiate or support such action. Yet, the perhaps evolutionary old and most conserved mechanism has been mostly off the map so far: reactive oxygen species (Physical-technical applications extend into medicine for diagnostics and also therapies, such as: cancer treatment. Tumor cells present various receptors on the cell surface, and immune cells can interact with these receptors to decide whether a cell should be eliminated or not. Therapies or other external influences can change the spectrum of the presented receptors and thus the interaction, aiming to stimulate an immune response. Once a tumor cell gets identified as harmful, an immune response is initiated to recruit cytotoxic T cells and other adaptive immune cells to reduce tumor growth. Physical plasmas are therapeutic and have antimicrobial efficacy and cancer-killing effects. Plasmas can be generated to operate at low temperatures, which enables them for medical applications, and produced reactive oxygen and nitrogen species (ROS) mainly induce biomedical effects. In tumor cells, plasma treatment leads to redox stress, followed by altered surface marker expression, which has immune-stimulating properties. However, ROS are not absent when the tumor cell dies, and further ROS-mediated mechanisms, such as oxidation of released biomolecules, continue. I hypothesize that immune-stimulatory properties of plasma are combinatory effects of molecular changes and biomolecule oxidation, suggesting that a standardized plasma treatment with maximized ROS, more precisely radical production, optimizes biomolecule oxidation and immunological consequences. My vision is to establish a novel approach to plasma-treated cancers by oxidizing cancer lysates with plasma for use as a therapeutic vaccine.

Keywords: cap free radical chemistry gas plasma technology low temperature plasma mass spectrometry non thermal plasma oncology plasma medicine ros redox chemistry
Competitive production of HMF and derivatives for an Eco-designed and Resilient Industry towards Sustainable European Autonomy (CERISEA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: France,Spain,Austria,Germany,Netherlands
Call: Bio-based dedicated platform chemicals via cost-effective, sustainable and resource-efficient conversion of biomass (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-04-01
End date: 2029-03-31
Duration (months): 48.0
Total project cost (EUR): 40487246.25
EU funding (EUR): 19999795.42
Participants: 16
Project status: SIGNED

In pursuit of offering solutions that are respectful of both human health and the environment, and supporting the resilience of European economy, Michelin Engineered Polymers and its partners join their forces to launch the CERISEA Flagship, aiming to produce for the very first time on industrial large scale, the highly important bio-based chemical platform: 5-HMF (5-Hydroxymethylfurfural), from fructose and advanced fructose from non-food side streams. HMF is a key intermediate between biomass and biochemicals and is known as the “Sleeping Giant”, due to its versatility and ability to replace a broad range of conventionally produced building blocks. However, today, there are no large scale industrial and profitable processes to produce HMF. CERISEA aims to be the first to awaken the Sleeping Giant. The project will demonstrate the broad range of bio-based sustainable applications for HMF including araminolic resins, crop science, functionalised bio-polymers (modified starch), functionalised compounds, polyesters, polyamides, polyurethanes and plasticizers. CERISEA bio-based products will meet market and technical performance requirements, facilitating the adoption of these solutions in the market. The project will be fully circular, with the valorisation of by-products called humins in 2 applications (araminolic resins and crop science). Also, the integration of HMF and humins (produced using a Process using fructose coming from wheat crops) in crop science and more specifically in biostimulants that will be tested on grains, including wheat, will demonstrate the creation of a truly circular system “from grain to grain”. The consortium includes 15 partners, of which 9 members of the Bio-based Industry Consortium (BIC) and 5 brand owners. It covers the entire value chain, from feedstock supply up to the end-users who have provide Letters of Intent. CERISEA will also implement synergies with the CBE Flagship PEFerence which is producing FDCA from a blend made of HMF.

Keywords: 5 hmf,humins,resins,crop science,functionalised bio polymers,functionalised compounds,polyesters,polyamides,polyurethanes,plasticizers,advanced fructose
Implementation of new machine learning algorithms for the optimisation of drug formulations (MACHINE-DRUG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Luxembourg
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Correctly developing and predicting crystalline forms with specific physico-chemical properties is essential to the pharmaceutical industry. The main challenge this industry faces is the fact that most active pharmaceutical ingredients in most drugs can interconvert into a different (usually more stable) polymorph, potentially reducing the solubility of the drug, slowing down the release of the API and affecting the pharmacokinetics, bioavailability and efficacy of the drug. For instance, due to the complex interplay between thermodynamics and kinetics, it often happens that unexpected polymorphs emerge either in development (best case scenario) or long after the drug has been approved for market (worst case scenario). A previously known stable form that disappears or the sudden appearance of an even more stable form can have grave consequences. For instance, the new form may have new properties that are not suitable for the intended purpose of the drug, leading to significant economic and public health repercussions. This ERC Proof of Concept project aims to implement new machine learning approaches that would allow to accelerate the process of predicting crystal structures by a factor of 100, thereby making it sustainable and enabling industry to investigate other crystal structures of the same drug to find the most suitable formulation (e.g. hydrates, salts, co-crystals, etc). Beyond pharma (which is our target application for MACHINE-DRUG), polymorphism of chemical structures has significant importance across many other different industries. For instance, the polymorphism of a pigment can generate a different colour, or the polymorphism of a chemical structure can lead to a material with significantly different properties (thermal, plastic, etc.). As such, MACHINE-DRUG is a lean, targeted project with a clear scope, but its potential applications are limitless.
Converting methane into green fuels using electrochemical devices (COMFUELS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-07
End date: 2026-08-06
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

This proposal titled "Converting methane into green fuels using electrochemical devices (COMFUELS)"will achieve efficient electrochemical methane conversion in a gas diffusion methane conversion cell through few-layer 2D materials-supported, transition metal oxide catalysts. We will exploit our expertise in the preparation of metal nanostructures by electrodeposition, preparation and modification of few-layer 2D materials, and electrocatalysis. This will provide a new generation of high-performing catalysts for sustainable methane conversion into value-added fuels, enabling the scientific community to exploit the potential of gas diffusion methane electrolyzers. The fellow, Manila Ozhukil Valappil, is an expert on 2D nanostructures and electrocatalysis. The supervisor, Prof. Maria Escudero Escribano at the Catalan Institute of Nanoscience and Nanotechnology, ICN2 in Barcelona, has long-standing expertise in (spectro)electrochemistry, electrocatalysis, materials science and surface nanostructuring for various electrochemical applications, and has secured an ERC-Consolidator Grant (June,2023-present) on tailored materials for electrochemical methane activation and conversion into valuable chemicals such as methanol. Well-established advanced materials and electrochemical characterization facilities at ICN2 ensure the project’s success and will provide a unique environment for the development of MOV.

Keywords: electrochemical methane conversion,electrocatalysis,transition metal oxides
Impact of Protected Areas and REDD+ Projects on Deforestation and Development in Low- and Middle-Income Countries (CARBONDEV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 191343.12
EU funding (EUR): 191343.12
Participants: 1
Project status: SIGNED

Relocating efforts to mitigate CO2 and other greenhouse gases (GHGs) emissions to low- and middle-income countries (LMICs) seems like an appealing strategy to help contain global warming below 1.5°C. The CARBONDEV project explores how socio-political factors in developing countries affect the effectiveness of carbon offset projects, particularly REDD+ (Reducing Emissions from Deforestation and Forest Degradation) programs and studies the broader social and political consequences of conservation projects. The project will collect data from diverse sources such as REDD+ project geographical boundaries, satellite imagery, household surveys, and conflict datasets to study the effectiveness and socio-economic impacts of forest conservation programs. This action, unfolding at Nova SBE in Portugal under the guidance of Prof. Alex Armand will explore these research questions while offering training and career development and greatly enhancing my skills and fostering my career prospects. By conducting the project at Nova SBE, I'll broaden my network, strenghten my scientific skills at the intersection of development and environmental economics, and leverage my expertise in impact evaluation, econometrics, and spatial data analysis to expand their research capacity.
The evolution of human gut microbiomes in the plastics era (plasticOME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

The gut microbiome (GM) is essential to human health and its dynamics allow for compositional and functional changes, giving it the potential to help hosts to adapt to rapidly changing environments. Although there is growing concern and public pressure to understand the impacts of increased plastic pollution on human health, a detailed assessment of this xenobiotic’s impacts on GMs is a major gap in research that this proposal seeks to bridge. I hypothesize that given (a) human exposure to plastics began very late in human evolution at the turn of the 20th century, (b) this exposure is ever increasing, and (c) preliminary results from my previous research show associations between plastic ingestion and changes in GM diversity and compositions, then plastics likely play a role in shaping GMs and their functions in modern humans. I aim to test this hypothesis by (1) determining the prevalence of plastic-degrading (PD) microbes and functions across modern GMs in order to (2) validate and characterize in vitro a subset of candidate gut microbes’ capacity for previously unidentified PD to finally (3) investigate plastics as a modulator of modern GMs. This will unveil unexplored factors behind the evolution of human gut microbiomes that could lead to the discovery of new plastic degrading microbes relevant for plastic pollution remediation strategies. This project takes an unconventional and multidisciplinary approach by exploiting advances in microbiome research encompassing bioinformatic tools and databases, applying these to the plastics field, and targeting humans. By building on my existing skills in wildlife and microbial ecology and plastics research and expanding them into human and computational metagenomics (strengths of the host), I am confident that plasticOME will enhance my academic profile at the unique crossroad between metagenomics and plastics research, allowing me to grow into an independent group leader.

Keywords: human gut microbiome,computational metagenomics,metagenomic plasticity,plastics,plastic pollution,xenobiotics,ecology,anthropogenic disturbances
Developing a ground-breaking chemical-free train wash system that recycles up to 99% of water, reduces energy consumption by 90% and is manufactured in the EU from recycled and recyclable materials (OrangeTWS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2497250.0
EU funding (EUR): 2497250.0
Participants: 1
Project status: SIGNED

Trains continuously operating in all weather conditions require regular washing to enhance safety, facilitate inspection, reduce wear/corrosion to mechanical components & coachwork, and present a professional image to customers. Existing washing systems use harsh chemicals, lots of water and energy and trains must be driven to and from them, often distant depots for cleaning. This is time-consuming, wasteful and can have a huge negative environmental impact. This project directly addresses the clear need to transform water and energy usage, whilst drastically reducing the carbon footprint and environmental damage caused by this essential process. Rail industry experts Dura Composites Ltd will develop and demonstrate the performance of a groundbreaking sustainable system that: •Uses zero chemicals, up to 99% less water & up to 90% less energy than alternatives; cleans carriages 22 times faster. •Recycles ≥90% of water used (no water run-off). •Is 78% cheaper to buy & ≥90% cheaper to operate. •Is manufactured sustainably using recycled & recyclable GRP composites (low carbon footprint) and advanced energy-efficient production technology. •Has a smart IoT platform for remote monitoring, reporting, maintenance & demonstrating carbon savings offsetable by carbon credits. •Has modular design for rapid construction (3-4/month increasing to ≥7-8/year), on-site installation (3-5 days permanent, 1-day temporary) & maintenance. The proposed technology will have significant positive socio-economic & environmental impacts. However, demonstrating its performance in a live rail environment is critical to accelerate route to market, capitalise on huge interest already shown by key stakeholders and enable business growth. This system will revolutionise the rail/transport and benefit train, underground & tram companies and operators across the EU & worldwide, with increasing demand as more emphasis is put on energy & environmental conservation by governments and stakeholders.

Keywords: chemicals free,water and energy saving train washing system,low carbon footprint,demonstrable carbon savings,groundbreaking technology for rail transport industries,recycled and recyclable