Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
THE LANDSCAPE AND FUNCTIONAL IMPACT OF TUMOUR-SPECIFIC GENOMIC INSERTIONS OF 1,000 CANCER GENOMES (CANCER INSERTOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Somatic structural variation (i.e., those structural rearrangements arising in a tumour) is found in almost all cancer genomes studied in detail. Current next-generation sequencing (NGS) strategies allow the identification of genomic structural variation with an unprecedented base pair resolution, revealing a complex landscape of somatic rearrangements in several cancer types. The studies carried out so far have focused upon four main types of rearrangement, namely deletions, amplifications, inversions, and translocations, but the complement of somatic insertions that characterizes cancer genomes remains mostly unexplored. These genomic insertions are mainly caused by transposable elements (TEs) and exogenous viruses, and despite the fact that these sequences can lead to disease little is known about the extent they can generate diversity in somatic cells and contribute to cancer development. Thus, taking advantage of the availability of the sequencing data generated by the international cancer genome consortium (ICGC), the purpose of this project is to use NGS data to explore and characterize the landscape of somatic insertions attributable to TEs and exogenous viruses in human cancer. TASK 1 of this project aims to identify the somatic insertions due to TEs and exogenous viruses in a total of 1,000 human cancer genomes for breast, bone and blood. A unique bioinformatics pipeline will be developed to identify the entire complement of somatic insertions by the analysis of whole-genome sequencing data of these cancers. TASK 2 aims to determine if somatic insertions in Task 1 impact gene function, by investigating the presence of aberrant splicing and/or gene expression and aberrant methylation profiles using RNA sequencing data and whole-genome methylation data. This project will provide essential insights into structural and functional impact of genomic insertions in cancer. This will lead to a better understanding of molecular mechanisms involved in oncogenesis.

Keywords: l406 cancer and its biological basis,l201 genomics - comparative genomics - functional genomics,l210 bioinformatics
Characterizing the risk of pesticide use on amphibian and reptile populations based on multiple, ecologically relevant responses (HERPESTI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 223778.4
EU funding (EUR): 223778.4
Participants: 1
Project status: CLOSED

Environmental pollution is recognized as one of the major causes involved in amphibian global declines, in spite of which amphibians are not considered in risk assessment of some pollutants like pesticides, being supposedly protected through data retrieved from other vertebrate taxa. This proposal has two focuses; on the one hand, I will identify the impact of pesticides on amphibian populations using novel, ecologically relevant endpoints indicative of population status and viability, such as reproductive behaviours, immune response and pathogen resistance. On the other hand, I will use these ecologically relevant endpoints to check whether protocols of risk assessment of pesticides are effective in protecting amphibians and reptiles from their impact; with this purpose I will compare the pesticide effects on native amphibians and reptiles based on reproductive, immunological and behavioural studies, with effects on surrogate taxa. A field monitoring in areas of pesticide use will serve to characterize the exposure in realistic scenarios. The relevance of the proposal lies in that it i) deals with a recognized major environmental problem (i.e. amphibian and reptile declines) from the perspective of multiple stressors, ii) presents a clear multidisciplinary scope combining zoology, ecology, toxicology, immunology and analytical chemistry, iii) shows many possibilities for transfer of knowledge to governmental agencies through the identification of relevant guidelines for conducting pesticide risk assessment, and to the industrial sector through the development of the best models to be used in such risk assessments; and iv) has potential for further development as validated models will be useful in extended taxonomical, geographical or chemical scales

Keywords: v307 environmental toxicology,v304 conservation biology - ecology - genetics,l601 innate immunity,l602 adaptive immunity,v301 animal behaviour,v405 agroindustry
The 1429 Catalan Translation of Giovanni Boccaccio’s “Decameron:” Tracing the Making of a European Classic (DECAMERONTRANSLATED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Composed in the wake of the Black Death (1348), the Decameron is a foundational text in the construction of European cultural identity. It profoundly influenced the form and content of narrative fiction in diverse western European traditions, in a process in which translation played a major part. This proposal seeks to analyse the 1429 Catalan translation of Boccaccio’s Decameron through a set of interrelated studies, including a partial digital edition. The Catalan text will be considered both in its own right and in its relations with readings and rewritings of the Decameron across different countries (France and Italy) and social milieus (the courtly nobility and rising urban bourgeoisie). The Catalan Decameron poses distinctive problems to scholars, since it is the result of a dynamic, and particularly complex, process of textual and linguistic sedimentation. To do justice to this process, DecameronTranslated draws on a multidisciplinary approach that brings codicology, palaeography and textual criticism together with digital resource development, and that is informed by key insights from reception theory and translation studies. Study of the complete Catalan text, its process of composition and its relationship with the Italian and French tradition of the Decameron, will generate a digital edition of Day 10 and a short monograph on the complete work. By building on my existing competencies, and by giving me high-level skills in applying digital tools to studying and editing pre-modern texts, the DecameronTranslated project would enable me to deliver expertise that is increasingly in demand throughout Europe, including in my home institution. This will equip me to take on research leadership roles, and to have an impact on scholarship across an unusually wide range of medieval romance literary studies.

Keywords: s412cultural heritage,s205 computational linguistics,s206 historical and comparative linguistics,s301 classics,s304 textual philology and palaeography,s303 literary theory and comparative literature
Alternative promoters as biomarkers in Inflammatory Bowel Disease (MARKIBD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Duration (months): 24.0
Total project cost (EUR): 221154.6
EU funding (EUR): 221154.6
Participants: 1
Project status: CLOSED

Inflammatory Bowel Disease (IBD) affects up to 1 in 200 individuals in Europe. Current diagnosis of the two main subtypes of IBD (Crohn’s disease and ulcerative colitis) is based on endoscopy, radiology and the examination of biopsies with a high degree of uncertainty: 20% of patients are not classifiable or are rediagnosed later. The uncertainty in diagnosis extends also to medication, which is to a large degree based on trial and error. The use of molecular biomarkers could allow for an earlier and more specific diagnosis of disease type and more targeted therapy; this is the aim of my project. My hypothesis is that differences between inflamed and non-inflamed tissue and between disease subtypes may not only be due to differential gene expression but also to alternative promoter usage, which may lead to altered protein products with modified or aberrant function. I will apply genome-wide experimental and computational methods to study differential promoter usage i) in colon tissue biopsies from IBD patients and ii) in the model system Caco-2, where we can investigate the effect of inflammation and perform functional validation of the promoters found in patients. The aim of this is to identify alternative promoters as biomarkers for diagnostics. As one of very few research groups worldwide, my host group uses a novel technique, Cap Analysis of Gene Expression, to identify transcription start sites genome-wide, which will allow me to quantify promoter usage and to find alternative promoters. Through the project I will obtain expertise in the growing field of high-throughput sequencing analysis, while my background in bioinformatics and immunology will contribute to the success of the project. As a result, the project will provide biomarkers for diagnosis of disease subtype with the aim to make diagnosis of IBD easier and more precise, allowing for better treatment and thereby improving the quality of life for patients as well as reducing health care costs.
Improved biological treatment of acid mine drainage and nitrogen impacted waters from mining industries (BIOTREATMIW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-01-01
End date: 2016-12-31
Duration (months): 36.0
Total project cost (EUR): 282226.8
EU funding (EUR): 282226.8
Participants: 1
Project status: CLOSED

The overarching objective is improved treatment of mine effluent, thereby mitigating its impact on ecosystems of recipient waters and surrounding environments. This will be achieved through a multidisciplinary approach that integrates microbiology, analytical chemistry and environmental engineering for the application and development of methods for functional analysis of biogeochemical reactors treating acid mine drainage (AMD) and nitrogen impacted waters from mining industries. For AMD-treatment, microbially driven sulfate reducing bioreactors are suitable and nitrate removal from mine discharge may be achieved using denitrifying microbial biofilms. The processes are promising but require improved understanding and monitoring tools to allow for optimization, prediction, performance sustainability and evaluation of greenhouse gas emissions (CH4 and N2O respectively). Optimization of these processes will be achieved using molecular microbiological- and advanced biogeochemical analyses. Spatial distribution and dynamics of microbial functional genes for the processes of importance will be assessed in full- and lab-scale. Together with analysis of biogeochemical zonation and monitoring of greenhouse gas emissions, this will provide a diagnostic tool for evaluation and prediction of treatment performance. Lab columns for manipulation of influent and substrate concentrations will allow for performance optimization.

Keywords: v408 biotechnology - bioreactors - applied microbiology,v201 biogeochemistry - biogeochemical cycles - environmental chemistry,v201 pollution (water - soil) - waste disposal and treatment,v305 ecology
New trends in microwave spectroscopy (MWSPEC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-06-01
End date: 2016-05-31
Duration (months): 36.0
Total project cost (EUR): 261627.6
EU funding (EUR): 261627.6
Participants: 1
Project status: CLOSED

The available microwave technique can supply precise information on conformation, structure, bond energy, internal motions and, sometimes, on charge distribution within molecules and molecular complexes. A lot of improvements are now possible in MW spectroscopy with the chirped-pulse Fourier transform microwave spectrometer (CP-FTMW) invented by Prof. Brooks Pate in recent years. The objectives of this project are to progress significantly in this field. The evolutionary improvements applied to the instruments will allow to get new information about: 1) Biomolecule Microwave Spectroscopy: the topic will develop techniques that have the potential to expand the use of microwave spectroscopy as a diagnostic tool for biomolecule structure (up to 50 heavy atoms) and to provide additional structural characterization when the rotational spectrum is insufficient to unambiguously determine the structure; 2) Atmospheric and astrophysical molecules millimiter-wave spectroscopy: improve the sensitivity of the method by taking full advantage of recent advances in technology and develop an analytical instrument for trace gas analysis; 3) Rotational Spectroscopy Probes of Molecular Dynamics: develop a project that would use rotational spectroscopy to probe chemical reaction dynamics following laser excitation, using the line shape analysis of the dynamic rotational spectrum. All this experience will be later on used to the final set-up molecular beam MW spectrometers combined with laser ablation, electrical discharge and 2D resonance. It will allow the study of rotational spectra of various molecules of astrophysical interest and biological interest. Moreover the main activity will be the design of a CP-FTMW spectrometer which will introduce in Europe new spectroscopic techniques.

Keywords: c101 physical chemistry,c103 spectroscopic and spectrometric techniques,c107 chemical physics,c108 chemical instrumentation
Novel semiconductor Optical sources for Metrology, Signal PrOcessing and Space applications. (NOMOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 202405.8
EU funding (EUR): 202405.8
Participants: 1
Project status: CLOSED

The purpose of this study is to review and assess novel technique of stabilized sub-picosecond optical pulse production based on compact and efficient semiconductor mode-locked lasers for application in LIDAR via the design, manufacturing and performance characterization. The design and assessment of selected semiconductor mode-locked laser architecture is based on considerations and trade-offs of the state-of-the-art technologies and device concepts enabling high relative accuracy of 10-9 in optical distance measurements. Mode-Locked Semiconductor Lasers systems (MLSCL) are the most compact, efficient and reliable sources of ultra short optical pulses, with high repetition frequency. They find nowadays applications in various domains ranging from optical telecommunications to fluorescence lifetime imaging. Historically the laboratory demonstrations in 70-th started at first with GaAs/AlGaAs devices emitting in the NIR range. Later on the emphasis shifted to quaternary InGaAsP alloys with the target objective on optical telecommunication wavelength ranges at 1.33 and 1.55 µm. Today several technologies, among which are SESAM based VECSELs and monolithic cavity edge emitting lasers, have found a niche in telecom market. At the same time novel application domains appear related to expansion of the wavelength range due to novel material systems such as group-III nitrides and advance in optical frequency comb technology. The project aims at developing the Mode-Locked Semiconductor Laser technology which have the best potential for LIDAR applications, especially in terms of pulse duration / repetition rate and shape, pulse energy, laser wavelength and beam quality.

Keywords: g205 micro- and nanoelectronics - optoelectronics,g206 communication technology - high-frequency technology,g301 aerospace engineering,p207 semiconductors
Micro-foundations of Entrepreneurial Dynamics (MED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Entrepreneurship is recognized as important for growth. European policies to facilitate entrepreneurship, however, have been less successful than expected and the EU continues to lag other advanced economies. This may reflect an incomplete understanding of the underlying processes affecting firm creation. The incoming fellow will enhance the potential for identifying economic and social factors associated with the creation and survival of new firms. While the primary context will be the UK, elements of the project will involve other EU countries. The focus--the micro foundations of entrepreneurial development--will be on the interaction of entrepreneurial characteristics, ambitions, business strategies, and environmental factors, including policies, institutions and social context. Aston Business School (ABS) excels in economic aspects of entrepreneurship research, and will benefit from synergies drawing upon the incoming fellow’s background in sociology and management research. ABS has been a key player in the major international entrepreneurial research programme, the Global Entrepreneurship Monitor (GEM). The incoming fellow was not only the founding principle investigator of GEM, but also had a central role in developing longitudinal studies of the entrepreneurial process; Panel Studies of Entrepreneurial Dynamics (PSED) have been implemented in nine countries. The methodological expertise of the incoming fellow will facilitate expanding the GEM programme with a complementary longitudinal study, a UK–PSED. This will provide more precise information about factors preceding and accompanying the birth and growth of firms and will form the basis for improved theoretical analysis and fact-based policy recommendations around four specific research issues: the role of local social capital in entrepreneurship, informal versus formal businesses, commercial versus social objectives of entrepreneurs, and the successful transitions of start-ups to profitable new firms.

Keywords: e102 microeconomics,e107 industrial economics,e108 behavioural economics,e109 organization studies - strategy,e113 urban and regional economics,e112 social economics,entreprenurship,institutions
Optimization of the corrosion resistance of Friction Stir Welds in High Strenght Aluminium Alloys (COFRICTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-10-21
End date: 2015-10-20
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

This project will seek to establish the corrosion mechanism of friction stir welds in 7075 alloy and develop technical solutions and guidelines for improving the corrosion resistance of FSW welds in 7075 alloy. These objectives will be achieved through FSW process optimisation, mechanical testing, corrosion testing and microstructure characterisation. FSW welding trails will be carried out to develop procedures for achieving high quality welds in 7075 alloy and establish the effects of process parameters on the microstructure and mechanical properties of the weld. Different corrosion tests will be carried out to establish corrosion mechanism and generate technical data on corrosion and stress corrosion cracking behaviour of FSW welds in 7075 alloy. Microstructural evolution during FSW welding will be examined to establish characteristics of microstructures in different regions of the welded joint and their responses to corrosions/cracking. Technical solutions and practical guidelines for improving the corrosion resistance of FSW welds in 7075 Al alloy will be produced based on the results achieved.

Keywords: stress corrosion cracking,corrosion testing,friction stir welding,heat treatment.