Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of peroxisomal fatty acid β-oxidation in vessel sprouting (PerMet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

MAIN GOAL: To characterize the role of peroxisomal fatty acid oxidation (pFAO) and its relative importance in the differently active endothelial cell (EC) subtypes during blood vessel sprouting (angiogenesis). BACKGROUND & RATIONALE: Activation of ECs by growth factors such as VEGF induces vessel sprouting, requiring a switch from quiescent phalanx ECs to a leading tip EC and proliferating stalk ECs. The host lab recently showed that this angiogenic switch requires a metabolic switch, with specific roles for glycolysis and mitochondrial fatty acid oxidation (FAO). ECs also have peroxisomes, which metabolize very long chain fatty acids (VLCFAs), but nothing is known about the possible role of peroxisomes/pFAO in ECs. Multifunctional protein 2 (MFP2) is the key enzyme of pFAO. Initial data from the host lab indicates that MFP2 silencing in ECs impairs vessel sprouting in vitro. I hypothesize that pFAO regulates the tip/stalk/phalanx EC subtypes differently during sprouting and will examine the underlying (peroxisomal) metabolic mechanisms. METHODOLOGY: I will use a multidisciplinary approach, combining molecular and cellular biology, in vitro and in vivo angiogenesis models, and conditional mouse genetics, to characterize the role of MFP2 in vascular sprouting. I will use scRNA-seq to define the (peroxisomal) metabolic gene signature of the 3 EC subtypes and explore whether MFP2 loss results in population shifts of tip, stalk and phalanx ECs. Furthermore, I will use state-of-the-art metabolomics and 13C tracing to define the metabolic fate of peroxisomally metabolized VLCFAs, with the ultimate goal of evaluating their physiological relevance in ECs. NOVELTY AND TRANSLATIONAL IMPACT: The data promise first insights in pFAO’s role in vessel sprouting and the first (peroxisomal) metabolic gene signature of tip, stalk & phalanx EC subtypes at single cell level, and may identify pFAO genes as potential novel targets in strategies to inhibit pathological angiogenesis.

Keywords: angiogenesis,tip and stalk cells,peroxisomes and endothelial cells
Evolution of Physiology: The link between Earth and Life (EvolPhysiol)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Austria
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-07-31
Duration (months): 66.0
Total project cost (EUR): 1499998.0
EU funding (EUR): 1499998.0
Participants: 1
Project status: SIGNED

The history of life is a subject that attracts the interest from both researchers and the society in general - it is in the human nature to wonder about our own history. Our only sources of information about microbial evolution reside in genomic data and geological records. Major advances in sequencing techniques are overwhelming databases with rich and novel insights into microbial taxonomic diversity, in particular about new uncultured lineages. Through metagenomics we now know that they are there but we still do not understand what they are doing.The key to that understanding is not genomics, it is physiology.Our main impediment to understand environmental microbial life is our lack of insights into the physiology of newly discovered lineages, how they harness and conserve energy.While phylogenetic trees based on universal genes can be generated for thousands of lineages at a time, they do not represent the genome as a whole and, most importantly, due to lateral gene transfer, branching patterns in the tree of life have never correlated well with key physiological traits.The goal of this proposal, whose focus is physiology, is to better understand how microbes harness energy from available environmental sources, how they learned to use new ones, and how this process unfolded during microbial evolution.This will involve i) large-scale comparative phylogenetic analysis of genes involved in and genomically associated with physiology combined with ii) experimental data, using as evolutionary constraints geochemical records of available environmental energy sources.With a top-down approach this work will successively eliminate among extant biological traits ones that cannot be ancient, constraining the physiological space of older microbial solutions.This proposal will lead to testable predictions regarding the order of events in evolutionary bioenergetic transitions, the focus on biological energy harnessing will narrow the gap between geochemistry and microbiology.

Keywords: physiology,bioenergetics
CObalt-free Batteries for FutuRe Automotive Applications (COBRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Austria,Germany,Germany,Germany,Germany,Spain,Italy,Germany,Spain,Spain,Germany,Sweden,Sweden,Norway,Türkiye,Belgium,Norway,France,France,Netherlands
Call: Research and innovation for advanced Li-ion cells (generation 3b) (H2020-LC-BAT-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 11857352.5
EU funding (EUR): 11857352.5
Participants: 24
Project status: SIGNED

COBRA aims to develop a novel Co-free Li-ion battery technology that overcomes many of the current shortcomings faced by Electrical Vehicle (EV) batteries via the enhancement of each component in the battery system in a holistic manner. The project will result in a unique battery system that merges several sought after features, including superior energy density, low cost, increased cycles and reduced critical materials. To achieve these ambitious targets we will: upgrade the electrochemical performance by focusing on Co-free cathode, advanced Si composite as anode and electrolyte/separator; cell manufacturing and testing for electrical and electrochemical performance; leverage the use of smart sensors and advanced communication to optimise the system control; battery-pack manufacturing that deliver cost-effective and environmentally sustainable battery over its lifetime. The proposed Li-ion battery technology will be demonstrated at TRL6 (battery pack) and validated it on an automotive EV testbed. The involvement of several leading organisation for battery manufacturing ensure easy adaptation to production lines and scale up to contribute to a higher market adoption while helping to strengthen Europe’s position in the field. Overall, the project includes the participation of 3 universities, 7 RTOs, 4 SMEs and 5 enterprises covering the entire value chain and strongly engaging EU battery industry.

Keywords: crm free,high energy density next generation li ion batteries for ev
Populist nationalism in 'global' western India, 1920-1939 (GLOB-POP-NAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,India
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-06-30
Duration (months): 33.0
Total project cost (EUR): 193758.96
EU funding (EUR): 193758.96
Participants: 3
Project status: SIGNED

GLOB-POP-NAT proposes a new study of the transnational links between emerging Hindu nationalism (Hindutva) and contemporary European fascism in the 1920s-30s. Comprehending Hindutva as a form of populist extremism, through examining these thinks the project aims at a better understanding of the transnational nature of the radical populist right in the interwar period; and through this it seeks a better understanding of the radical right in comparative and historical perspective, and of global fascism as a concept. This project speaks to areas of vital current concern for the European Union. It reflects the Horizon 2020 Work Programme’s response to the challenge of fostering ‘inclusive, innovative and reflective societies’, itself a response to the remarkable growth in populist movements in Europe and globally in recent years. It refers in particular to the European Union policy on 'Racism and Xenophobia’ under its strategic priority of Justice and Fundamental Rights. The relationship between Hindutva and fascism, which emerged at the same time, has been subject to recent work, not least because of its timeliness to India’s own politics, and rise to power of the Hindu Nationalist Bharatiya Janata Party (BJP) since 2014. But this work lacks a focus on the geographical and cultural area which gave birth to Hindutva: Maharashtra, its western Indian heartland, which gave rise to its major institutions and founding ideologues. GLOB-POP-NAT fills this major gap in knowledge exhibited in the current state-of-the-art, proposing a vernacular study to offer in-depth insights on this relationship in Hindutva’s birthplace for the first time, and which the Experienced Researcher is expertly placed to undertake. The project is also innovative in blending regional and linguistic expertise with an interdisciplinary study of other aspects of vernacular culture to form a totalizing, holistic understanding of its regional political culture in the 1920s-1930s.

Keywords: populism,extremism,global fascism,hindu nationalism,transnational,radical right
Computing the Face Syntax of Social Communication (FACESYNTAX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 1490050.0
EU funding (EUR): 1490050.0
Participants: 1
Project status: SIGNED

Social interactions are critical to all societies. One of the most powerful tools for social interaction is the face – a complex system comprising variations of movement (expressions), morphology (shape/structure) and complexion (color/texture). Consequently, the face can elicit myriad rapid social judgments (e.g. personality, emotion, group membership, age, health, social status) with significant consequences (e.g. sentencing/voting decisions, social isolation, job offers). Yet, little is known about how the complex, dynamic face transmits the myriad messages that regulate social interactions in different cultures, how these complex face signals map onto psychological processes (e.g. categorical/dimensional perception) or which signals facilitate or hinder cross-culture communication. This is largely due to fragmented research on social concepts (mental states, personality, emotions), face signals (morphology, movements, complexion) and culture, which, consequently, has overlooked a possible latent algebraic, syntactical structure to social face signals across cultures. My own work hints at such a structure. My ambitious program will unify these fragments to derive the first generative, algebraic and syntactical model of social face signals using innovative methods combining social/cultural psychology, 3D dynamic computer graphics, vision science psychophysical methods, and mathematical psychology. It will thus test and validate a new theoretical framework of social face signals that will unite both categorical/dimensional and universal/culture-specific accounts of social face perception. This framework is highly relevant in the context of globalization and cultural integration where social communication using virtual agents is integral to modern society. It is thus imperative to equip digital agents with the tools to flexibly generate socially and culturally sophisticated face signals. FACESYNTAX will thus transfer the generative model to social robotics.

Keywords: social communication,face perception,culture,psychophysics,modelling,dynamic signals
European Microkelvin Platform (EMP)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Switzerland,Finland,Slovakia,Sweden,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2018-1, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 9984192.66
EU funding (EUR): 9941065.75
Participants: 17
Project status: SIGNED

The European Microkelvin Platform (EMP) provides access to the ultralow temperature frontier approaching absolute zero. The Platform is continuously evolving by extending its reach, building on the integration achieved through previous infrastructure calls. Europe already has a significant research lead in the microkelvin regime and we will reinforce this by encouraging the further exploitation, in both the shorter and longer term, of ultralow temperatures for the development of new concepts, new applications and new devices, especially in the fields of nanoscience, materials research and quantum technology in all its forms. The EMP is a consortium of 17 partners which provide an extensive portfolio of capacities and expertise in ultralow temperature physics. Since this is a fast evolving and expanding frontier field, we also lay considerable weight on improving and upgrading our infrastructure, since the lowest accessible temperatures are continuously falling. These advances allow us, and our users from across Europe, to study new phenomena, thereby generating new knowledge, applications and commercial opportunities. We have a particular interest in the benefits of ultralow temperature physics for driving forward the inter-related areas of quantum materials, nanoscience, and quantum technology. The activities of the EMP hold enormous potential for innovation. A more extensive description of the Platform and its philosophy can be found in Nature Reviews Materials, The European Microkelvin Platform, Nat. Rev. Mater. 3, 18012 (2018).

Keywords: matter under extreme conditions,ultra low temperatures
Integrated Refractory and Steel Recovery (ReStoRe)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-03-01
End date: 2022-02-28
Duration (months): 36.0
Total project cost (EUR): 4073157.5
EU funding (EUR): 2851210.25
Participants: 1
Project status: CLOSED

The steel industry is a strategic production sector, however it puts strong pressure on the environment because of the nature and quantity of material involved, gas emissions and waste. Of particular concern are 1) the huge volume of landfilled spent refractory, about 80-90% of total ladles and furnaces demolition material; and 2) the massive lime consumption, generating large amounts of CO2 emissions. To date no technology existed in the steel industry that achieved recycling rates higher than about 50%, can be performed in situ and permit the use of the vast majority of treated waste within the same production cycle. These assets would significantly reduce economic and environmental costs of steel production. Deref S.p.a. ( ‘DEmolizione REFrattari’) has a solid and long-lasting experience in the steel sector, and even more in steel refractory demolition, industrial waste management and metallurgical additives production. It developed a proper solution, tested it industrially at an Electric Arc Furnace plant for stainless steel production, and achieved a 95% recycling rate with 80% reuse in the same production plant and very high cost savings. It now sees a high potential to capitalise these huge achievements by focusing the entire steel production market - consisting in more than 18 relevant sized steel plants in EU and much more in the rest of the world. Hereto, Deref will optimise and adapt its patented and proven technology to all types of steel production cycles and steel grades and validate results within large-scale trials and demonstrations, performed with at least 7 big steel producers, to obtain confirmation on the suitability of the treatment cycles in different use cases and to provide for evidence to the market. It will also standardise protocols and designs, and obtain an ETV certification. Lastly, it will widely inform and convince the market by a well targeted communication and dissemination strategy and update the commercialisation plan.

Keywords: recycling,steel,refractory,circular economy,environment,lime,saving production costs
N-point statistics as a bridge between cosmological observations and the underlying physics (Cosmo-Bridge)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 264669.12
EU funding (EUR): 264669.12
Participants: 2
Project status: SIGNED

Over the last decades, we have established a standard cosmological paradigm by combining the information from complementary cosmological probes. However, many intriguing questions remain to be answered: the nature of dark energy, the driving mechanisms of the cosmic inflation, and masses of neutrinos. In this proposal, I will focus on the cosmological information content of the large-scale structure (LSS) of the Universe. Different physical processes leave their unique imprints on the clustering pattern of LSS at different scales, and N-point statistics act a bridge between the observables and the underlying physics. In the coming years, new large-volume galaxy surveys will probe the LSS of the Universe with exquisite detail. However, traditional analysis methods, based mostly on 2-point statistics alone, are not adequate for these new surveys and must urgently be revised to ensure their full potential. This proposal aims to maximise the information to be extracted from the upcoming surveys. With the Marie-Curie fellowship, I will carry out a consistent joint analysis of the 2- and 3-point statistics, and develop a complementary but simplified treatment of the N-point statistics. These tools will be applied to the new data to constrain the cosmological models, with special focus in understanding the properties of the primordial signatures and models beyond the standard cosmological paradigm. In the outgoing phase, I will work at Univesity of Florida (US) to benefit from the expertise in the leading algorithms to estimate higher-order statistics, their theoretical modelling, and knowledge about high-performance computing. In the incoming phase, I will work at the Max Planck Institute for Extraterrestrial Physics (Germany), I will delve into the data from the real surveys and understand potential systematic errors. With the help of the experts at MPE, the experience and techniques acquired in the US will be applied to the datasets to extract more precise information.

Keywords: galaxy redshift survey,n point statistics,modified gravity,neutrinos
Cold Atmospheric Molecules on a Chip (CAtMolChip)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2021-11-30
Duration (months): 66.0
Total project cost (EUR): 1985553.0
EU funding (EUR): 1985553.0
Participants: 1
Project status: CLOSED

Highly excited electronic states of small atmospheric molecules play an important, but as yet little explored, role in the reactivity, and in the evolution of plasmas, including the Aurora Borealis, in the upper atmosphere of the Earth. Processes involving these highly excited states are very challenging to investigate theoretically because of the high density of states close to the ionization limits where they lie. Therefore, experimental input is essential for the identification of the reaction and decay mechanisms, and the quantum states of importance in future studies. However, experimental techniques that can be exploited to provide this input have only become available very recently. These techniques permit gas-phase molecular samples in these highly excited states to be confined in traps for sufficient lengths of time (e.g. 1 ms – 10 ms) for detailed studies to be performed in a controlled laboratory environment. They include resonance-enhanced and non-resonance-enhanced multiphoton excitation of long-lived high angular momentum Rydberg states of small molecules, and chip-based devices for efficiently decelerating, transporting and trapping these samples. With the support of this Consolidator Grant a new experimental research program will be developed in the Department of Physics and Astronomy at University College London involving laboratory based studies of (1) inelastic scattering processes, and (2) the decay mechanisms of gas-phase atmospheric molecules, including N2, O2 and NO, and their constituent atoms, in high Rydberg states. The planned experiments will be directed toward understanding the effects of static and time-dependent electric and magnetic fields, and blackbody radiation fields on slow dissociation processes that occur in highly excited states of N2, O2 and NO, investigations of collisional energy transfer processes, and studies of the role that these excited electronic states play in the evolution and reactivity of atmospheric plasmas incl

Keywords: rydberg states of atoms and molecules