Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Generative idleness and gestures of reparation: the resurgence and promises of intentional fallowing practices in European regenerative agriculture (FALLOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: CLOSED

This project proposes to investigate the resurgence of intentional fallowing as a practice for soil regeneration and as a tool for sustainability policies in Europe. It will deploy an interdisciplinary approach grounded in philosophy and multispecies ethnography to analyse the contemporary resurgence and mutations of intentional fallowing practices in European agriculture and policies, as well as the cultural, social, and scientific consequences of this shift. It combines qualitative research on European farms conducting experimental intentional fallowing, a genealogical analysis of the historical and political context in which these practices are re-emerging, and an exploration of the adjacent spaces in which fallowing and fallowness are studied, such as microbiology, conservation biology, and bioengineering. By combining these three lines of inquiry, the project demonstrates that fallowing is a marginalised practice currently under re-evaluation and potential re-integration into projects and policies that go beyond agricultural concerns. It will analyse the biopolitical and cosmopolitical dimensions of this renewed interest in alternatives to synthetic fertilisers and intensive agriculture by showing that fallowed soils are a site where a variety of interests and projects converge, and by tracing how these practices take up, replay, and extend questions of productivity and idleness, growth and alternatives to economic expansion. This project will combine qualitative methods, in particular in-depth interviews with practitioners in the field, with an extensive engagement with literature in agricultural science, microbiology, conservation biology, and ecology, producing an analysis of fallowing that cuts across what is usually deemed “cultural” and “biological” domains and studies the role, promises, and implications of fallowing practices in times of mass extinction and soil depletion.

Keywords: interdisciplinary soil studies,cosmopolitics,fallowing,environmental humanities,science and technology studies,regenerative agriculture,biopolitics
Massive 2 to 3 two-loop amplitudes in asymptotic limits for collider phenomenology (BBJAmps)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 292118.88
EU funding (EUR): 292118.88
Participants: 1
Project status: SIGNED

The data taken at the Large Hadron Collider (LHC) at CERN and its future High-Luminosity upgrade enables the study of the fundamental interactions of matter at unprecedented precision and energy. After the discovery of the Higgs boson one of the major goals of the LHC is the precise measurement of its properties. In order to achieve the needed theoretical precision, two-loop corrections to many scattering amplitudes have to be computed. A crucial process to precisely determine the coupling of the Higgs boson to the bottom quark is the production of a Higgs, a Z-boson, and a jet. This process receives large contributions and accompanying uncertainties from the sub-process of gluon fusion, which only starts contributing at the one-loop level but is enhanced by the large gluon luminosity at hadron colliders. To improve the theoretical description of this sub-process and enable the most precise determination of the Higgs-bottom coupling, the two-loop five-point amplitudes of this sub-process will be computed in this project. The results of this project can also be applied to double Higgs production, which the crucial experimental signature to determine the Higgs self-interaction at hadron colliders in the future. The computation of five-point amplitudes with massive internal and external particles is a tremendously difficult task, due to the algebraic complexity of the amplitudes and the appearance of new classes of special functions. To tackle and circumvent some of the difficulties I will explore the systematic approximation of these complicated amplitudes in various kinematic limits, like small Mandelstam variables or the high-energy limit. This methodology has already proven successful for two-loop four-point amplitudes previously. The results of this project will, therefore, significantly enhance our ability to obtain precise theory predictions for high-multiplicity processes and simplify their calculation and numerical evaluation.

Keywords: scattering amplitudes,qcd,perturbative qcd,lhc,collider physics,high energy phenomenology
Air Traffic Control Trajectory Based Operations (ATC-TBO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Belgium,France,Bulgaria,Poland,Netherlands,Italy,Germany,Spain,Romania,Ireland,Denmark,Switzerland,United Kingdom,Sweden,Austria,Croatia,Portugal
Call: Industrial Research & Validation for Connected and Automated ATM (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 25730681.75
EU funding (EUR): 11808172.62
Participants: 32
Project status: SIGNED

The Air Traffic Control - Trajectory Based Operations (ATC-TBO) project proposes to validate TBO SESAR Solutions for flights in the tactical execution phase for en-route and TMA operations, thus contributing to the finalisation of the SESAR Phase C developed in SESAR 2020 and the realisation of the Digital European Sky vision in SESAR Phase D. The results are expected to contribute to capacity, operational efficiency, safety, environment and cost efficiency. The SESAR Solutions, with the TRL/EOCVM levels at the start and end of the project are: • Solution #4: Improved automation in sector planning and separation management via enhanced trajectory predictions and controller tools, including the completion of Solution 53A from SESAR 2020 to V3 (Initial = TRL4/V2; Target = TRL6/V3) • Solution #5: Improved air/ground trajectory synchronisation via lateral and vertical complex CPDLC clearances to support TBO, including completion of Solution 56 from SESAR 2020 to V3 (Initial = TRL4/V2; Target = TRL6 /V3) • Solution #6: Advanced separation management function concepts and tools, making use of more reliable trajectory information and advanced use of datalink/CPDLC (Initial = TRL1/2 (V0/V1); Target = TRL4/V2) The ATC TBO project consortium - with EUROCONTROL as the project coordinator, and steering from the PMB and the SJU - brings together 14 ANSPs, 1 airspace user, 10 airborne and ground industry partners, 5 research establishments, and 1 university. 14 EU member states, Switzerland and the UK are represented. The proposal describes 21 validation exercises including real-time simulations, fast-time simulations, and expert groups. The 'design', 'development & validation', and 'data pack & maturity gate' phases are planned for the second half of 2023, 2024, 2025 and the first half of 2026.

Keywords: tbo,cpdlc,automation,sesar,trl,atc tbo,conflict detection and resolution
On the Prosodic Interface: Towards the Typology of Prosody in Tonal Language (ITFprosd)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Prosody is the melody and rhythm of speech. All languages use prosody in one way or another. English uses falling or rising tune (also known as intonation) in the expression of communicative functions such as making a statement, asking a question, and highlighting part of the utterance. Different tunes (also known as tone) are also used in tonal language to distinguish lexical and/or grammatical meanings along with intonation. Cross-linguistic examination of the prosodic patterns sees problems in analysing prosody and its dynamics with grammar and information structure in tonal languages where tone and intonation entangled by using the same acoustic parameter of pitch. Among tonal languages, Tibeto-Burman languages are significant in understanding prosodic typology because they are outliers in Asia, with tone functions and patterns that resemble African-type tone languages. ITFprosd will investigate the typology of prosody of tonal language and examine the prosodic interfaces through a fine-grinded analysis of an endangered Tibeto-Burman language of Tsum. ITFprosd innovatively integrated fieldwork-based data collection with theoretical data analysis and will contribute three theoretical innovations addressed to the prosodic interface studies literature, the prosodic typology, and Lexical Functional Grammar (LFG). It employs a mixed method to provide empirically rich, granular analyses of prosody through the investigation of natural speech data in Tsum. One aim of the project is to understand how prosody interacts with other grammatical aspects in tonally complex language. The second contribution lies in its implication for prosodic typology. By conducting a comprehensive examination of the prosody in Tsum, what does Tsum tell us about the typology of Tibeto-Burman language and beyond? Thirdly, ITFprosd will enrich current theoretical perspectives on and advance the field of prosodic interface study with novel empirical data from Tsum using the framework of LFG.

Keywords: prosodic interface,tonal typology,endangered language,lexical functional grammar,himalayan language
Development of brain-permeable masked nanobody-drug conjugates to eliminate glioma stem cells (ADC2GBM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Glioblastoma multiforme (GBM) is one of the most prevalent brain tumours and is currently incurable. Patients die from tumour recurrence after resection and chemotherapy. New treatments need to overcome two great challenges: reaching the tumour margins, where the blood-brain barrier (BBB) is intact, and eradicating glioma stem cells (GSCs), which cause tumour relapse. Targeting receptors overexpressed on cancer cells with antibody-drug conjugates (ADC) has shown great promise in cancer treatment. However, most receptors on GSCs are also present in normal stem cells. Thus, targeting these receptors with antibody-drug conjugates may lead to severe side effects. The main objective of this proposal is to develop a masked nanobody-drug conjugate with the capacity to overcome the BBB and to be activated only in the tumour to selectively target GSCs. Nanobodies have increased capacity to penetrate tissues and biological barriers but none is yet available to target the GSC marker CD133. Therefore, I will generate new nanobodies against this receptor. Subsequently, I will set up a phage display platform to develop masked nanobodies that can be selectively unmasked by tumour proteases. The masked nanobody will be conjugated to a drug and then to a BBB-shuttle peptide. A panel of conjugates will be screened in vitro for target selectivity, efficient activation and BBB transport. Finally, the efficacy of the most promising candidates will be tested in a GBM mouse model. Our unique combination will generate the first bispecific nanobody-drug conjugates targeting GSCs to treat GBM. The concept of GSC-targeting with activatable ADC may change the current paradigm for the treatment of brain tumours. Furthermore, our workflow may be applied to dramatically enhance the efficacy of other biotherapeutics with on-target off-site dose-limiting effects.

Keywords: glioblastoma,therapeutic antibodies,drug discovery,phage display,nanobody,antibody drug conjugate,blood brain barrier,bioorthogonal chemistry,site specific protein modification
Dual Mn/Ni-catalysed functionalization of unreactive sites of amines (DualCatAmine)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

With most bioactive molecules, such as pharmaceuticals, and agrochemicals, being complex amines, efficient synthesis and functionalization is of crucial importance. Although much progress has been achieved, conventional strategies, especially those targeting the functionalizations of less reactive sites, are particularly ineffective. The current methods typically require forcing conditions, such as strong oxidizing agents and stoichiometric organometallic reagents or the installation of directing groups and N-protected functionalities, that jeopardize their utility in practical synthesis. To address these limitations, herein, we propose a new strategy for the direct and efficient functionalization of amine frameworks at their otherwise unreactive sites. Specifically, I will explore the dual Mn/Ni-catalytic systems, where the unique features of the Mn complexes drive the temporary activation of an amine generating a transient reactive imine intermediate, which in turn undergoes the functionalization step enabled by the Ni complexes. Attractively, the overall transformation employs Earth-abundant metals and occurs directly in ‘one pot’ without any stochiometric activating reagents, thereby underscoring the high atom economy enabled by multicatalysis. The mechanistic studies will be used to untangle catalytic aspects assisting the rational methodology development. Attractively, a range of functionalizations, including arylation, alkylation, olefination, and halogenations at different sites can be achieved, which will open up innovative routes to industrially important and value-added chemicals. This highly original project combines the strengths of complex systems chemistry with the power of catalysis to address the current limitations of organic synthesis, yielding a project of excellent, innovative science that will exploit my unique expertise in Mn catalysis while providing me extensive training in multicatalysis, reaction networks, and computations.

Keywords: multicatalysis,functionalization of amines,c h functionalization
Examining victim-blame and rape proclivity toward male sexual minority victims of rape (VictimPro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-05
End date: 2027-11-04
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

According to a recent report of the European Commission (EC), the feeling of discrimination among sexual minorities is rising, with many experiencing hate speech and violence, including rape. An EU survey of LGBT individuals showed that many of rape incidences go underreported. Victim-blaming by bystanders has been considered as a key driver for why victims remain silent. While previous research has focused on victims’ experiences, there has been less attention on bystanders’ perspectives, despite their potential impact on victims. Therefore, my proposal will address this gap by examining bystanders’ perspectives regarding sexual minority victims of rape. VictimPro will examine the mechanism of victim-blame and the drives behind rape proclivity toward heterosexual, bisexual, and gay male victims of rape by testing the role of the defensive attribution and sexual attraction hypotheses. My research will adopt an interdisciplinary approach involving psychology, criminology, and victimology. The findings will contribute to improve victim support, reduce underreporting, identify vulnerable groups, and inform rape prevention programs. The methodological novelty of my project lies in proposing a model on the overlap between victim-blame-rape perpetration using advanced statistics. This model will deepen our understanding of the perceptions toward rape victims and can be tested with further research examining public perceptions toward other victims of rape. This project aligns with the EC's current strategy (2020-2025) to fight discrimination and ensure the safety of LGBTIQ people. Beyond the project’s timeliness, benefits, and innovative aspects, this fellowship will expand my theoretical and methodological expertise in the field of sexual violence, provide mobility experience as well as strengthen my international academic network and transferable skills essential for a successful academic career.

Keywords: rape victimization sexual violence victim blame rape proclivity sexual minorities criminology psychology
Advancing Hybrid Implant Technologies: Integrating Titanium and Magnesium-Based Innovations (HITECH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

Aseptic loosening, responsible for about 55.2% of hip arthroplasty revision surgeries globally, is primarily caused by stress shielding. While biomedical titanium (Ti) alloys offer high specific strength, they are bioinert and contribute to stress shielding. Conversely, magnesium (Mg) alloys, with their lower Young’s modulus, reduce stress shielding and offer better biocompatibility, although they suffer from issues of uncontrolled degradation. Therefore, combining Ti and Mg in composites holds promise for improving bone repair by harnessing the benefits of both materials. However, the contact between dissimilar metals (Ti and Mg) in body fluids can cause galvanic corrosion, which accelerates the degradation of Ti-Mg hybrid implants. To address this issue, the HITECH project proposes using a bioactive magnesium oxide (MgO) coating at the Ti-Mg interface. The project aims to advance hybrid implants for hip arthroplasty by achieving four key objectives: (1) Developing a fabrication process that incorporates additive manufacturing, bioactive coatings, acid etching, and capillary-assisted pressure-less infiltration techniques; (2) Controlling galvanic corrosion through surface modification of Ti; (3) Evaluating mechanical behaviors under in vitro corrosion conditions; and (4) Enhancing in vitro biocompatibility by integrating osteoblast-type cells. The project seeks to merge Dr. Dutta’s extensive material knowledge and experience, combined with the biomedical expertise, diverse backgrounds, and broad collaboration networks of the supervisors, supported by the state-of-the-art infrastructure at Helmholtz Zentrum Hereon. This interdisciplinary research spanning metallurgy, advanced coatings, bio-laboratory work, and modeling will broaden Dr. Dutta’s expertise and significantly enhance career opportunities. Helmholtz Zentrum Hereon will benefit from the researcher’s contributions to its research initiatives and industrial applications.

Keywords: composite,titanium,magnesium,corrosion,biocompatibility,implants
De novo formation of the generative plant meristem in 4D (DeNovoMeristem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 262287.09
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

Meristem formation is essential for continuous and organised growth in all land plants. The meristem is a multicellular generative centre that produces the plant body and is maintained by spatially restricted gene expression domains throughout a plant’s lifespan. However, little is known about how these stable patterns are established de novo from a single cell. This is because embryonic meristem formation in flowering plants is enclosed within the seed and fruit and therefore live imaging, chemical treatments and gene interaction studies are technically difficult. The bryophyte Marchantia polymorpha has emerged as a powerful model to investigate meristem formation in real time. The single-celled Marchantia haploid spore is exposed and undergoes defined patterns of cell division to ultimately produce a highly organised meristem. In the proposed project, spatial and temporal gene expression changes will be observed live during meristem formation, and the molecular interactions driving these changes will be identified. As well as revealing how gene expression patterns and feedback loops can form de novo, this work will reveal key innovations during meristem evolution and identify the fundamental requirements for meristem formation in land plants.

Keywords: plants,meristems,stem cells,patterning,gene expression,marchantia,spores