Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional assays for membrane protein on nanostructured supports (ASMENA)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Switzerland,Sweden,Germany,France,Hungary,Netherlands,United Kingdom,Sweden
Call:  (FP7-NMP-2007-SMALL-1, 2007)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 5435545.2
EU funding (EUR): 3940098.0
Participants: 14
Project status: CLOSED

More than 50% of all drug targets are membrane proteins; new research tools to screen function of membrane drug targets are therefore expected to open up new avenues for original drug development. The proposed project addresses the need of the pharmaceutical industry for new technologies for reliable and efficient screening of membrane proteins as drug targets. Most critical current aspects of membrane protein assays are (a) the lack of reliable procedures to immobilize membrane proteins on sensor surfaces in a format suitable for label-free high-throughput screening of drug candidates; (b) the need for downscaling assay formats to accelerate functional screening; and (c) the feasibility of reading out the diverse functions of membrane proteins. The partners – with highly complementary expertise and experience of working together – will develop platforms for functional membrane protein assays by integration of the most recently gained knowledge and techniques. The key concepts of the platforms include (a) exploitation of nanoporous substrates to enhance the stability of supported proteolipid membranes and their integration in a sensor chip format; (b) nanoscale surface modifications for directed self-assembly of proteolipid structures on chip; and (c) self-assembly of proteolipid membranes onto nano-sized sensor structures from proteoliposomes, and demonstration of the functionality in quantitative drug candidate screening assays suitable for commercial applications. The project is expected to make a substantial contribution to (a) improved understanding of lipid membrane and membrane protein interaction with designed nanoenvironments; (b) development of prototype products and intellectual property related to membrane protein sorting and handling; (c) new compounds for functionalization of biosensor applications; (d) cost-effective array-based concepts for nanoplasmonic and electrochemical sensing; and (e) functional assays for membrane protein drug targets.

Keywords: membranes,supported lipid bilayers,nanopores,transmembrane proteins,aquaporins,ion channels,responsive polymers,nanoplasmonics,electrochemistry,drug targets,drug screening,self-assembly
Self reconfigurable intelligent swarm fixtures (SWARMITFIX)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: New production
Action type: Collaborative project
Countries involved: Italy,Italy,Poland,Slovakia,Italy,Sweden
Call:  (FP7-NMP-2007-SMALL-1, 2007)
Start date: 2008-10-01
End date: 2012-01-31
Duration (months): 40.0
Total project cost (EUR): 3695367.4
EU funding (EUR): 2649045.0
Participants: 6
Project status: CLOSED

A step beyond flexible/reconfigurable fixtures for higher continuous adaptation of production resources respect to production objectives and technical conditions in the knowledge-based factory is achievable today by synergic convergence of the NMP themes of flexible fixtures, parallel robots and new/smart materials with the ICT themes of robot swarms with networked embedded control. Today’s smartest adaptable fixtures have limited adjustment capability, are mostly operated manually, are usually setup off-line with help of external measuring equipment, e.g. laser. Significant increase in effectiveness and decrease in cost may come from on-line fully actuated configuration/reconfiguration, large adaptability to different shapes and the capability to dynamically concentrate the support in the region where manufacturing is actually performed, doing that on-line and without moving/removing the part from the fixture. We propose the new concept of self adaptable swarm fixtures composed of mobile agents that can freely move on a bench and reposition below the supported part behaving as a swarm, all without moving/removing the part from the fixture. Each fixture agent is composed of: *A mobile platform, *a parallel robot fixed to the mobile platform, *an adaptable head with phase-change fluid and an adhesion arrangement, to sustain/clamp the supported part perfectly adapting to the part local geometry. A hybrid control system is adopted and each robot is treated as an autonomous agent exhibiting its own behaviours. Behaviour based translocation of the robots to destination positions is adopted to reduce planner complexity, with *no need to plan exact trajectories and *no significant increase in complexity when extra units are removed/added. The area of manufacturing of thin metal sheets is considered (aircrafts and automotive bodies). The project objective is to develop a swarm fixture for a large range of sheet shapes to fully replace the specialized fixtures today used.

Keywords: flexible fixture,adaptive fixture,multi-agent swarm system
Context-aware data-centric information sharing (CONSEQUENCE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: United Kingdom,Italy,United Kingdom,Germany
Call:  (FP7-ICT-2007-1, 2007)
Start date: 2008-01-01
End date: 2010-12-31
Duration (months): 38.0
Total project cost (EUR): 4619299.4
EU funding (EUR): 2899895.0
Participants: 7
Project status: CLOSED

An efficient, fast and seamless data exchange is vital for today’s society. At the same time such exchange should not create risks of violating confidentiality and privacy that may be associated with the data. To deliver a technology that would effectively fit both of these strategic needs is an important technological as well as economical and social challenge. The Consequence project will deliver a Data-centric information protection framework based on data-sharing agreements. In particular the project intends to: 1) Define a generic, scalable, context-aware, secure and resilient architecture within a framework to enable dynamic management policies based on agreements that ensure end-to-end secure protection of data-centric information incorporating: - Models, algorithms, and tools for specification/authoring, elaboration, analysis, and management of multiparty data sharing agreements; - Models and implementation of Risk and context-aware policy refinement mechanisms; - Secure mechanisms for enforcement of controlled data sharing. 2) Engineer an interoperable software implementation of the architecture. 3) Evaluate the technical and business benefits of the implementation and framework via two test beds. 4) Widen the use of agreements and policy enforcement, and improve best practices in secure data and information sharing through a significant impact on the community. The Consequence Framework will help to fill the gap between today’s business requirements in the area of controlled data sharing and currently available technology offerings. It will also exceed the functionality of today’s solutions that are usually focused on commercial content licensing rather than dynamic data sharing. The project Consortium combines strong industry players and academic institutions which will deliver high quality research and development. The project outcome will be evaluated via two industrial test beds. The proposal is relevant to the objectives of ICT-2007.1.4

Keywords: consequence,data sharing,data sharing agreement,policy refinement,policy enforcement,data dissemination,privacy,context-aware data access,secure data access
Integrated approaches to study gene regulation during cellular differentiation (INTEGER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece,Netherlands,Germany,United Kingdom,United Kingdom,Italy,United Kingdom
Call:  (FP7-PEOPLE-2007-1-1-ITN, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 2300000.0
EU funding (EUR): 2300000.0
Participants: 8
Project status: CLOSED

Cellular differentiation from stem cells to fully functional mature cells is a multi step process executed by complex transcription programs. Once differentiated, cells must faithfully maintain their identity through cellular memory mechanisms. The utilisation of genetic information stored in linear DNA sequence occurs within the three dimensional context of chromatin, chromosomes and the nucleus, all of which contribute to gene regulation mechanisms. The main aim of this ITN is to get a comprehensive view on the mechanisms controling gene expression during cell differentiation by integrating studies on multiple regulatory levels from DNA binding transcription factors through to nuclear organization. We will take a multi-faceted approach addressing the functions of: (i) transcription factors and their co-factors (ii) chromatin domains and histone variants, (iii) epigenetic mechanisms of cellular memory and identity, (iv) global gene interactions in nuclear space and (iv) nuclear territories of gene activity. Genomics approaches will be employed to describe global changes in gene target networks and gene interactions in the nucleus during ES cell differentiation into the hepatic, neuronal and hematopoietic lineages. Proteomics will be employed for the characterization of transcription factor and epigenetic modifying complexes and of the in vivo protein composition of specialized chromatin domains. The research activities of this ITN are organized in the context of a multidisciplinary Training Program, which provides unique opportunities for the training of early stage researchers to address fundamental biological questions with far reaching implications in biotechnology and human health.

Keywords: stem cells,transcription factors,chromatin,epigenetics,genomics,nuclear structure
Extended Large (3D) Integration TEchnology (ELITE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: France,United Kingdom,Sweden,Italy,Germany,Germany
Call:  (FP7-ICT-2007-1, 2007)
Start date: 2007-11-01
End date: 2011-08-31
Duration (months): 46.0
Total project cost (EUR): 5628834.0
EU funding (EUR): 3600000.0
Participants: 6
Project status: CLOSED

For developing complex next-generation chips which include a combination of disparate technologies, the circuit integration exclusively in two dimensions has proved to be a seriously limiting factor. Utilising the third dimension for integration of complex chips is a promising technique for removing the bottlenecks in two-dimensional (2-D) integration. Advantages of third-dimension (3-D) integration are in first order form factor and power dissipation. The proposed project ELITE aims at miniaturization and density increase beyond Moore by means of exhaustive die stacking. It takes as development vehicle an advanced solid state drive which will widely substitute traditional hard disk drives for purpose of mobile and hand-held applications and which is considered as the enabler of the up-coming era of mobile data. The system architecture will include a large amount of non-volatile flash memory, one or more microcontrollers and external analog high-speed interface. One of the main topics of ELITE will be the development of a technology for vertical die stacking and for vertical interconnect. Starting from the expertise and experience of the consortium new technology modifications or alternative technologies will be investigated. Also assembly technology will be investigated considering possible later usage in mass-production with its specific requirements on manufacturability and cost. Conceptual and physical simulations will be deployed for planning and ensuring the system architecture and specifying a demonstrator which will prove the feasibility of the concept. Firmware inside the chip will be used to optimize performance by means of parallel tasks, guaranty highly reliable data access as well as controlling power dissipation. As a final step, generalization of the results which are reached with the solid-state drive vehicle will be generalized in order to be re-used for applications from different technical domains and markets.

Keywords: mass storage,die stacking,three-dimensional integration,3-d integration,miniaturisation,nanoelectronics,system-on-chip,solid-state memory,processors,portability,ambient intelligence
Compliance-driven Models, Languages, and Architectures for Services (COMPAS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: Austria,Netherlands,France,Germany,Netherlands,Italy,France,Poland
Call:  (FP7-ICT-2007-1, 2007)
Start date: 2008-02-01
End date: 2011-01-31
Duration (months): 36.0
Total project cost (EUR): 5602803.0
EU funding (EUR): 3917723.0
Participants: 9
Project status: CLOSED

The COMPAS project will design and implement novel models, languages, and an architectural framework including required software components and services to ensure dynamic and on-going compliance of software services to business regulations and the stated user service-requirements. This is achieved using the model-driven software development (MDSD) approach to enable organizations developing custom business compliance solutions faster, cheaper, and with less required programming skills. We devise a “design-for-compliance” technology framework which will be used to ensure compliant composition of business processes and services and that will allow specification, validation, and enforcement of comprehensive compliance policies related to these processes and services. To provide a framework for satisfying compliance concerns pertaining service compositions and permit re-use of this, we will enhance business process languages, such as (but not limited to) the Business Process Execution Language (BPEL), with enforceable compliance concepts and policies. Furthermore, we will develop specification languages and models for expressing typical compliance concerns. A formally grounded and implemented behavioural model for services and service composition will be provided enabling the formal validation of compliance of composed services to the behaviour and process constraints specifications. With our contributions, compliance concerns can be checked statically as well as dynamically. Finally, we will develop monitoring and management tools for tracking and validating those compliance concerns that can only be verified at runtime, thus enabling governance of compliance concerns. These tools will be complemented with reasoning and mining tooling that will help to “discover” compliant instances services and processes. COMPAS is a NESSI Project and plans standardization of some parts of its contributions.

Keywords: service-oriented computing,service-oriented architectures,web services,service compliance,model-driven development
Service Oriented Architectures for All (SOA4ALL)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: Spain,United Kingdom,United Kingdom,Germany,Austria,Italy,France,Ireland,France,Spain,Netherlands,Germany,Bulgaria,Spain,Austria
Call:  (FP7-ICT-2007-1, 2007)
Start date: 2008-03-01
End date: 2011-04-30
Duration (months): 38.0
Total project cost (EUR): 13386634.0
EU funding (EUR): 9474415.0
Participants: 21
Project status: CLOSED

Computer science is entering a new generation. The emerging generation starts by abstracting from software and sees all resources as services in a service-oriented architecture (SOA). In a world of services, it is the service that counts for a customer and not the software or hardware components which implement the service. Service-oriented architectures are rapidly becoming the dominant computing paradigm. However, current SOA solutions are still restricted in their application context to being in-house solutions of companies. A service Web will have billions of services. While service orientation is widely acknowledged for its potential to revolutionize the world of computing by abstracting from the underlying hardware and software layers, its success depends on resolving a number of fundamental challenges that SOA does not address today. SOA4All will help to realize a world where billions of parties are exposing and consuming services via advanced Web technology. The outcome of the project will be a comprehensive framework and infrastructure that integrates four complimentary and revolutionary technical advances into a coherent and domain independent service delivery platform: • Web principles and technology as the underlying infrastructure for the integration of services at a world wide scale. • Web 2.0 as a means to structure human-machine cooperation in an efficient and cost-effective manner. • Semantic Web technology as a means to abstract from syntax to semantics as required for meaningful service discovery. • Context management as a way to process in a machine understandable way user needs that facilitates the customization of existing services for the needs of users. SOA4All is endorsed by the NESSI constituency as an Strategic Project and will contribute significantly to the NESSI Open Framework, which is one of the main challenges of the European Platform on Software and Services.

Keywords: semantics,dynamic composition,dynamic context-awareness,wsmo,web services,web 2.0,internet,open environments,mediation,discovery,service providers,service consumers,nessi
Extending Professional Active Life (EPAL)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for Independent Living, Inclusion and Governance
Action type: Coordination and support actions
Countries involved: Portugal,Netherlands,Spain,United Kingdom,Spain
Call:  (FP7-ICT-2007-1, 2007)
Start date: 2008-02-01
End date: 2010-01-31
Duration (months): 27.0
Total project cost (EUR): 1120124.9
EU funding (EUR): 800000.0
Participants: 5
Project status: CLOSED

Project ePAL aims to explore innovative ways to best facilitate the development of the active ageing process and to ensure an improved transition for the elderly citizen as they cope with the onset of age. In order to find appropriate ways towards this goal, a strategic RTD roadmap is proposed focused on innovative solutions and ensuring a balanced post-retirement life-style. The ePAL vision – addressing new levels of quality of life – is that of an effective transformation of the current situation regarding retirement and the barriers to active ageing in Europe by introducing new approaches and ways to create actively contributing professional communities in society, which provides the elderly citizen with a supporting framework for leverageing their talents and expertise and creates value for the benefit of the Europe’s economy. Moreover, such a framework would also support a balanced transition towards retirement. The ePAL vision will do much to place Europe as the leader in promoting active ageing worldwide. ePAL aims at identifying and characterizing the key research challenges, required constituency, and the implementation model for a comprehensive approach to support in innovative ways the increasing numbers of professional retirees in Europe. ePAL proposes a feasibility study and development of the roadmap covering a comprehensive approach for discovering new ways to promote a balanced active life for retired professionals and a sustainable new notion of silver economy with a wide societal impact.

Keywords: active ageing,silver economy,affective computing,evolving behavior,roadmap
COntinuous MOnitoring of Medication Overuse Headache in Europe and Latin America: development and STAndardization of an Alert and decision support System (COMOESTAS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Towards sustainable and personalised healthcare
Action type: Collaborative project
Countries involved: Italy,Denmark,Germany,Argentina,Chile,Spain,Italy
Call:  (FP7-ICT-2007-1, 2007)
Start date: 2008-01-01
End date: 2010-12-31
Duration (months): 36.0
Total project cost (EUR): 1971386.0
EU funding (EUR): 1600000.0
Participants: 10
Project status: CLOSED

Appropriate delivery of quality healthcare requires constant monitoring of the patient during follow up, particularly in the presence of chronic diseases. This approach can be further improved if leading edge tools supporting diagnosis, as well as prediction, identification and monitoring of adverse events are available. COMOESTAS aims to develop an innovative ICT system that allows patients with a chronic condition to receive continuous and personalized treatment. The whole system is based on an advanced, “all-in-one” Alerting and Decision Support System that follows patients from the diagnosis and supports the physician in managing the therapy, controlling relevant events impacting on patient safety and activating specific procedures if selected thresholds are exceeded. In the frame of chronic neurological disorders, Medication Overuse Headache (MOH) is a common condition and a major cause of disability. MOH is curable, but its outcome is hampered by a high risk of relapse. It is, therefore, a perfect example of a disorder that can benefit from an ICT-assisted approach developing innovative systems and services for monitoring chronic conditions. COMOESTAS goals will be achieved by improving and integrating the traditional paper headache diaries and calendars into an innovative ICT tool taking into account the complex issues that accompany this peculiar form of headache, which will make the patient a key node in the entire process (Patient-centric Health Care System). This will be achieved through an EU-LA consortium incorporating, in addition to the ICT component, top-level centres for headache and pain management. The project will ensure the appropriate transfer of technology and the uptake of EU standards in healthcare informatics, clinical protocols, patient treatment and management, as well as a better healthcare quality and improved cost-effectiveness.

Keywords: patient safety,alerting and decision support system,electronic health records,eu standards,neurological chronic disorders,medication overuse headache,quality healthcare,personalised treatment.