Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Autonomous Patch for Real-Time Detection of Infectious Disease (A-Patch)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Israel,Switzerland,Belgium,Finland,Latvia,France,France,Netherlands
Call: Flexible and Wearable Electronics (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 4009087.5
EU funding (EUR): 4009087.5
Participants: 10
Project status: CLOSED

The A-Patch Research & Innovation project will research, innovate, push technology barriers, and demonstrate innovative use of Flexible and Wearable Electronics in the medical and well-being sectors, validate its prototype devices in lab and hospital environments (TRL 4-5). Industrial exploitation of the A-Patch applications will be clearly identified. The project will develop non-invasive autonomous wearable diagnostic patches for real-time remote monitoring of infection status. The A-Patch will use a novel intelligent hybrid sensor array with multiplexed detection capabilities to detect disease-specific volatile organic compounds (VOCs) from the surface of the skin, enabling rapid and highly-accurate diagnosis using a small device. Product innovations for professionals and consumers will be incorporated, and benefits demonstrated. Integration of electronic devices in connected wearable, flexible and stretchable settings, low-power interconnection, compatibility with low-cost manufacturing, efficient energy scavenging and storage, functional performance, and durability will be successfully demonstrated. To ensure reliability and enable extended usage periods, the sensor array will be self-repairing and the device will be self-powered, by advancing cutting-edge research on chemical hybrid sensors and materials. A-Patch will incorporate secure transmission to enable privacy-ensured diagnosis monitoring by physicians, national health systems and worldwide health organisations. The project partners include a health-maintenance organisation, a diagnostic test implementer with in-depth understanding of end-user needs, technology developers, academic / research institutes and a system integrator. The project is planned for a 36-month duration and is estimated to require total funding of 4 M€.

Keywords: sensing patch,skin,tolae,pilot production,self healing,self powering,medical diagnostics,disease detection
Fear reduction strategies relevant for exposure therapy: Devaluation and extinction learning in anxiety disorder patients and their neurobiological basis (ReduceFear)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2024-01-17
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

My ambition is to become an independent PI and clinical psychologist with a novel research line focusing on treatment optimization and personalization for anxiety disorders and post-traumatic stress disorder (PTSD). The MSCA-IF will provide the essential building blocks for this research line, and provides the opportunity to develop generic skills necessary to transfer from a postdoc position to an Assistant Professor position. Training through research: I will bring my expertise in neuroimaging and clinical psychology to the host, and the host’ PI will train me in experimental task development. The aim of ReduceFear is to examine fear reduction strategies that play a role in exposure therapy, the gold standard therapy for anxiety disorders and PTSD. These disorders are highly common, and up to 50% of patients do not benefit from the therapy. The project will concurrently assess (a) extinction learning, a process that reduces the over-expectation of harm but is highly fragile and dysfunctional in anxiety patients, and (b) threat (US) devaluation, a highly-understudied process that has potential to more robustly reduce excessive fears by reducing the perceived aversiveness of the threat. Overall objective: to examine for the first time (1) the neurobiological mechanisms of US devaluation compared to extinction learning to identify (pre)clinical targets for therapy augmentation, and (2) US devaluation mechanisms in patients with anxiety disorders. If anxiety patients not show any deficits in US devaluation, exposure-based therapies may be adapted to enhance focus on US devaluation. Hands-on training: As identified by a Gap Analysis, I will work on the following competences in order to reach scientific maturity and to successfully lead my own research group in the future: (1) Networking, (2) Time-management / Self-management, (3) Grant Writing, (4) Leadership, (5) Teaching, and (6) Communication/Dissemination.

Keywords: functional mri,psychological therapy,experimental psychology,anxiety,ptsd
A Multiscale Analysis of Bacterial Predation (JAWS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2370352.0
EU funding (EUR): 2370352.0
Participants: 1
Project status: SIGNED

Predation arguably impacts the evolution and shape of ecological systems. This process occurs at all scales from mammals to viruses. Predatory bacteria remain poorly studied despite their biological importance and often versatile experimental tractability. In this project, we propose to remedy this gap and study the molecular, cellular and ecological aspects of a collective bacterial predatory behavior. Specifically, capitalizing from previous molecular studies on motility, we will investigate how Myxococcus xanthus invades prey colonies and directly feeds on the prey cells by contact-dependent killing. We will then explore how the Myxococcus cells disseminate throughout the prey colony as concerted waves, thus preparing the next predatory cycle. While these experiments will be conducted in laboratory context, we will link molecular mechanisms of predation to ecological dynamics that actually occur in the wild directly by genomic analyses of environmental isolates and experimental evolution of predator-prey interactions. The feasibility of the project is guaranteed by the development of a new imaging tool (Bacto-Hubble) that captures the entire predatory cycle at single cell resolution. In addition, our laboratory recently identified for the first time the Myxococcus genes that promote contact-dependent killing, paving to molecular studies of prey killing and consumption. This project is uniquely multiscale and its realization requires true interdisciplinarity. For this, we will assemble a large collaborative network to connect approaches from the realms of genetics, structural biochemistry, theory and modeling and large-scale genomics. At the end of the project, we expect to obtain a first spatially resolved molecular blueprint of the Myxococcus predatory cycle, which will provide a framework to understand other multicellular predatory processes and well as their evolutionary trajectories.

Keywords: bacterial predation,cell motility,evolution of predator prey interactions,multicellular patterns,contact dependent killing
Unraveling long-term soil organic matter dynamics under drought in forest soils and their link to ecosystem properties (DRYSOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2023-03-24
Duration (months): 28.0
Total project cost (EUR): 237007.68
EU funding (EUR): 237007.68
Participants: 1
Project status: CLOSED

Severe drought periods are predicted to increase in Central Europe. The increasing frequency of drought will affect the growth and carbon (C) storage in forests. While drought effects have intensively been studied for plants, much less is known about their impact on soil processes. Soils store more C than atmosphere and vegetation together, and contribute to CO2 removal and thus to mitigate climate change. The proposed project aims to estimate how reoccurring summer drought affects long-term dynamics of soil organic matter (SOM) in forest soils. Our research will be carried out in a unique 15-year-long irrigation experiment in a dry oak and pine forest. The project will advance the knowledge and improve its transfer between disciplines by (1) tracing C inputs and fluxes from roots and mycorrhiza into soils and losses of ‘old’ SOM by applying novel isotopic approaches, and relating these changes to soil microbiota analyzed by DNA, (2) determining drought impacts on SOM stability and its sources by innovative marker molecules approaches in SOM pools, and (3) linking these results ecosystem properties measured by collaborating research groups. The use of a long-term experimental set up, together with novel techniques, will offer a unique opportunity to identify the unknown drought-induced effects on belowground C cycling at long time scales. These results will be important for facing current climate change impacts, and will be communicated not only to scientists but also to policy makers and to a wider public. The project will enhance the researcher’s skills in cutting-edge methodologies and techniques, boost teaching and writing skills and increase communication competences, through an ad-hoc spectrum of training activities. As such, future career opportunities will highly improve and the fellowship will be a key milestone for the researcher to become an independent and leading scientist in research on SOM dynamics in forests under long-term drought.

Keywords: soil carbon,climate change,molecular markers,radiocarbon,stable isotopes,soil microbiota,rhizosphere
Optimal Orchestration of Virtualized Network Functions for Improved Quality-of-Service (OTIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-07-01
End date: 2024-07-11
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Telecom networks provide vital communication infrastructure and play a key role in promoting the economic and social well-being. Network Function Virtualization (NFV) is an emerging, promising and cost-efficient technology for future Internet by decoupling the traditional network functions from dedicated hardware and running them as software-based virtualized instances, known as Virtual Network Functions (VNFs). To effectively support the emerging NFV technology, how to orchestrate VNFs and achieve improved Quality-of-Service (QoS) has become a timely burning challenge faced by the networking research community. This project aims to develop a new suite of optimal VNF orchestration schemes to boost the network performance and enhance the QoS. To this end, I will firstly design innovative Service Function Chains (SFCs) that are built from a set of chain-ordered VNFs in a parallel pattern to accelerate the network performance. Secondly, I will develop an optimal QoS-aware VNF placement approach to map the parallel SFCs into the underlying network infrastructure, which considers the important QoS metrics as a multi-objective optimization problem. Finally, I will establish a software package with two components for SFC parallelism and VNF placement and develop an experimental testbed to evaluate the proposed solutions. The scientific breakthroughs to be made in this project will contribute to provide the effective design and solution implementation of NFV network innovations. The originality of this research lies in its advocate of designing a parallel SFC paradigm and the optimization of VNF placement to satisfy the QoS requirements of ever-increasing network services. Furthermore, a series of research, training, and knowledge transfer activities will be conducted to accomplish the scientific objectives and enable me to receive professional training, broaden an interdisciplinary research background, and gain more experiences in project management and collaborations.

Keywords: computer networks,software defined networking,network functions virtualization,service function chains
UK150330_Support to the provision of services Enhancing the innovation management capacities of SMEs by the Enterprise Europe Network in 2014 (UK150330_IMCpilot)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom,United Kingdom
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-05-01
End date: 2014-12-31
Duration (months): 8.0
Total project cost (EUR): 56000.0
EU funding (EUR): 44800.0
Participants: 2
Project status: CLOSED

The overall aim is to ensure that Scottish SMEs with international innovation and growth ambitions are empowered by unlocking their full growth potential through better internal innovation management capability. The underpinning objective of this proposal is therefore to pilot the development of a quality and workable Enterprise Europe Network delivery service in Scotland that supports SMEs to increase their innovation management capacity and to innovate successfully and profitably. This requires not only a focused SME targeting strategy, but also qualified staff trained on appropriate tools and methodologies, delivering the right support to the right SMEs, coordinated with other delivery teams with the Enterprise Europe Network Scotland (EES) host organisations. This proposed pilot project will cover the whole of Scotland, through the two innovation focussed partners of the EES consortium: Scottish Enterprise (SE) and Highlands and Islands Enterprise (HIE). The majority of the activity will be carried out in the Scottish Enterprise region, which accounts for 91% of the population.

Keywords: enhancing client smes capacity to manage innovation processes,key account management of successful sme instrument applicants
Transition-Metal Mediated Chemistry in Cells (MetalCell)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-12-01
End date: 2017-11-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Over the past decade, metals which were previously restricted to conventional organic synthesis have begun to be used in an increasing number of biological settings. This has been dominated by copper mediated catalysis of the azide-alkyne Huisgen cycloaddition (1,3-dipolar addition) chemistry (the well know “click reaction”) but other, less toxic, metals such as palladium are now beginning to establish themselves in the chemical biology/ chemical medicine arenas. In this proposal, building on chemistry from the Bradley group (see Nature Chemistry, 2011 and Nature Communication, 2014) the potential of palladium mediated chemistry in living systems will be exploited. This will cover three main avenues of exploration: (i). The fabrication of active palladium catalysts conjugated to antibodies and small targeting peptides; (ii) Development of assays to allow the activity of the active catalysts to be determined both in vitro and inside cells and (iii). The application of these active palladium catalysts enable the conjugation of two drug “halves” to allow the in situ synthesis (inside cells) of active anticancer drugs. This fellowship will bring together chemistry, biology and medicine, with potential longer-term biomedical applications with the training of the applicant in learning new chemistry and biological technique. This will be tied into an improvement of my independent thinking and leadership skills, gain of experience in writing grants and research articles and peer-reviewing and working in a multidisciplinary manner, with major opportunities to broaden my “soft-skills” set.

Keywords: chemical biology,palladium catalysts,in vivo synthesis,targeting peptides,nanoparticles,targeted drug therapy,cancer
An integrative analysis of shifting trends in dental traits in human populations from Neolithic to Iron Age (ANCIENT_TEETH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-06
End date: 2018-06-05
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

The transition to an agriculture lifestyle is one of the most important events in human evolution, resulting in significant biological, cultural and health changes. This shift started in the Great Hungarian Plain (GHP) around 6,000 cal BC, followed by several cultural and technological transitions during the next several millennia. The objective of the present project is to characterize, for the first time, the changes in dental traits of past European populations and the factors influencing these transitions, integrating data from several multidisiciplinary, state-of-the-art approaches. These will include: 1) Training in and obtaining high-resolution μCT data of upper and lower molars from a unique unstudied Hungarian time-series; 2) The characterisation of internal and external dental morphology trait changes through geometric morphometric and occlusal complexity methods; 3) The use of stable isotope analyses to analyse these populations’ diet; 4) The use of modern ancient DNA techniques (Next Generation Sequencing, NGS) for sexing individuals and subsequent study of sex differences in morphology and dietary regimes through time. This project will not only expand the knowledge of the consequences of adopting agriculture, but will also explain the origins of dental health problems in contemporary populations. More importantly, it will constitute the starting point for developing a long term project characterising the dental trait changes caused by dietary shifts and will provide insight into how these transitions took place throughout the continent. The project will enable the successful collaboration between the School of Archaeology and School of Medicine in University College Dublin, under the supervision of Drs. Ron Pinhasi and Robin Feeney, worldwide experts on the agricultural transition and μCT data processing, respectively. This project will broaden the multidisciplinarity of the prospective fellow and will propel her research career in the EU and worldwide

Keywords: cultural transitions,neolithic,iron age,great hungarian plain,diet,stable isotopes,wear,tooth morphology,geometric morphometrics,microtopography,past pospulations,ancient dna,molecular sex
Vaccine development against variable pathogens (VIVA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1750000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: SIGNED

Vaccination is the most effective strategy to prevent infectious diseases but despite years of research there are no vaccines against variable pathogens such as HIV-1. Contrary to what is required for non-variable pathogens, vaccines against genetically variable pathogens need to elicit antibodies specific for conserved epitopes to protect against the majority of strains. These antibodies are termed broadly neutralizing antibodies (bNAbs). bNAbs against the genetically variable HIV-1 surface protein Env are highly somatically mutated and develop in a fraction of infected individuals, but have thus far failed to be elicited by vaccination. For a vaccine to elicit antibodies against a specific epitope of a variable pathogen, it needs to specifically expand rare precursor cells in the presence of a polyclonal B cell response that bind other parts of the same antigen. Furthermore, it needs to guide the rare precursor cells through repeated germinal center reactions to induce high numbers of somatic mutations, a critical characteristic for the potency of HIV-1 bNAbs. To develop such vaccines, we need to understand the regulation of antigen-driven affinity maturation of B cells in a polyclonal immune system in response to complex antigens. To study this, we will perform immunization experiments of wild type mice, adoptively transferred to include a limited pool of naïve B cells from novel HIV-1 Env-specific human antibody knock-in mice. In contrast to conventional antibody knock-in mice that have been used to study B cell activation previously, naïve precursor B cells from these knock-in mice are specific for a complex pathogen-derived antigen. Detailed characterization of the immune responses that develop in response to Env- and non-Env-based antigens, will enable us to generate vaccines that more efficiently drive protective immune responses against variable pathogens such as HIV-1 and Influenza, as well as potential emerging diseases.

Keywords: b cell,germinal center reaction,hiv 1,broadly neutralizing antibodies,vaccine