Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next-generation haptic platform for advanced driver-assistance and mitigation of car accidents (Tactronik)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Driver distraction due to the use of mobile phones and other technologies is one of the main causes of road crashes, accounting for approximately 30% of road accidents, and causing about 21 deaths and 111 injuries per day on average only in Europe. The automotive and tech industries are pushing development and increasing adoption of Advanced Driver-Assistance Systems (ADAS) to enhance driver’s safety and to mitigate the consequence of distracted driving. Unfortunately, most ADAS are too slow in triggering the correct driver’s response to the impeding hazard, and often distract more the driver with annoying sounds or unpleasant and rudimentary effects. Moreover, they are currently very expensive and difficult to integrate in the vehicles, which makes them unsuitable for mainstream production. Actronika has developed Tactronik, an advanced driver-assistance platform integrated into the seat of a vehicle that predicts impending hazards and intelligently alerts the driver to prevent accidents and increase driving safety. Tactronik connects seamlessly to the vehicle ADAS sensors and delivers appropriate attention-grabbing tactile sensations through advanced haptic technologies, thus eliciting fast and accurate driver responses to the impending hazard. Tactronik integration is “plug-and-play”, making it suitable for mainstream commercialization. During the feasibility assessment, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. During the innovation project, Actronika will optimize Tactronik platform, validate its performance through in vehicle testing with automotive partners, and establish a partner ecosystem for Tactronik market entry.

Keywords: haptic technology,advanced driver assistance systems,distracted driving,driving safety,car accidents,hd haptic effects
Methane oxidative conversion and hydroformylation to propylene (C123)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Azerbaijan,Germany,Belgium,Belgium,Norway,France,France,France,Netherlands,United Kingdom
Call: Catalytic transformation of hydrocarbons (RIA) (H2020-NMBP-ST-IND-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 6353373.74
EU funding (EUR): 6353373.74
Participants: 15
Project status: SIGNED

Propylene production is classified as the 4th largest emitter of greenhouse gases among the major chemical compounds. As the polypropylene market is huge and still growing, it is essential to find alternatives to current, energy-intensive production processes to meet the European environmental challenges. Other C3 derivatives, more specifically propanol and propanal, are also very high added-value chemicals with growing markets, obtained via waste-generating and energy-consuming processes. Today, unused carbon resources are widely available and most of the time wasted.The C123 project’s main goal is the validation in a relevant environment (TRL5) of an efficient and selective transformation of current generally accessible, unexploited, cheap methane resources (stranded gas (CH4) and biogas (CH4+CO2)) to propylene in particular and C3 products in general. To this aim, C123 will develop new catalytic materials in novel process configurations and related operating procedures allowing the conversion of these resources to propylene through Oxidative Conversion of Methane, leading to an ethylene, carbon monoxide, and hydrogen mixture with an optimised composition for further HydroFormylation into propanal and/or propanol, ultimately being dehydrated into propylene, either in an integrated manner or as a stand-alone step. C123 will adopt an integrated approach, not studying each step separately but considering the process as a whole, optimising recycling, avoiding separation, using variable feedstocks, and increasing resource and carbon efficiency. The process will be evaluated and validated for implementation both as decentralised localised units (~10 kt/y) – the modular route, and in existing large facilities (>140 kt/y) –the add-on route. Throughout the development and thanks to the perfect complementarity of the partners and the very strong industrial commitment, emphasis will be put to maximise further exploitation of the results through industrial implementation.

Keywords: catalyst,metal organic framework,oxidative conversion of methane,propylene,hydroformylation,high conversion,micro kinetic modelling,thermal control,reactor design,modular
Algorithmic Approaches to Spatially-Informed Information Visualization (ALGOVIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2016-10-31
Duration (months): 14.0
Total project cost (EUR): 107015.3
EU funding (EUR): 107015.3
Participants: 1
Project status: CLOSED

We propose a fellowship that will propel an outstanding young researcher and provide him with the skills, experiences and contacts that will enable him to develop into a key contributor to international and interdisciplinary research in an important emerging field that has wide application in commerce, government and industry. Computational Geometry is largely theoretical whilst Information Visualization is broadly applied. The proposal focuses on a talented computational geometer, who has already begun working with colleagues and commercial organizations across the world to develop his research in an applied context with some success. It embeds him in a renowned Information Visualization group at CITY University London—an institution that is uniquely positioned both academically and geographically, with its portfolio of professional education and proximity to one of the world’s leading centres of technology-fuelled creative industry. The fellowship will provide access to academic expertise in a complimentary discipline, experience and training in research and entrepreneurship, and close collaboration with partners in industry and government. This interdisciplinary research and training will equip an experienced researcher with the skills, experience and contacts to move an important applied discipline forward in the future. With a programme that draws upon formal provisions within CITY and takes advantage of existing contacts with partners in London from the commercial sector, the fellowship will: (1) add algorithmic rigour to Information Visualization design; (2) inform algorithmic design through access to other disciplines and practitioners; (3) provide the researcher with experience of new fields and practices; (4) bring two complimentary fields together and change disciplinary mindsets; (5) develop the researcher through experience and training in research, teaching and entrepreneurship and by developing his international network across disciplines and sectors.

Keywords: information visualization,set visualization,spatial nonspatial trade off,stability
Scriptores Iuris Romani. Texts and Thought. (SIR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-12-01
End date: 2022-07-31
Duration (months): 80.0
Total project cost (EUR): 2025000.0
EU funding (EUR): 2025000.0
Participants: 1
Project status: CLOSED

The goal the PI intends to reach, in cooperation with scholars of the Universities of Roma 'La Sapienza', Pavia, Siena, Bologna, Cassino and others Italian and European Universities, is to create the basis – in texts and in interpretation - for a new approach to the remains of the ancient Roman jurists. What we suggest is an advanced paradigm in considering the most important part of Roman law: the Justinian Digesta, and other juridical Late antique anthologies. A change of perspective of great impact not only for the scholars in Antiquity, but also for a educated audience, interested in law and history. An historiographic model that will overturn current outlooks, making way for a different view, which seems to us of great interest today, both for legal and historical studies. No more the institutes, the norms and the rules of Roman Law –in the misleading form of the Code- but the effective legal thinking of its authors, the ancient iuris prudentes. Our aim is to focus the attention on their thought in the context of the time they belonged to. The achievement of the objective will be carried out through a reconstruction, and annotated edition, in several volumes, of the writings of jurists handed down in the Digesta and in other anthologies: an undertaking that has never been attempted. We will proceed by author and by work. A collection, entitled Scriptores iuris Romani (also available in e-book format) will gather the annotated editions. Each volume will consist of four parts (Introduction dedicated to the jurist considered and to his reconstructed work(s); Latin text (or Greek); Italian translation; commentary). The edition will be progressive and cover the entire period of the project.With regard to the choice of jurists to be edited, we will proceed by dealing with multiple authors and types of texts. About ten volumes are already anticipated. Another objective will be the creation of a website in which the texts will be published: thus for the first time, there will be a database on Roman legal thought.

Keywords: history of roman legal science,roman law,history of ancient ideas
Textiles and the Making of Israeli Modernism: From the Zionist Bauhuas to Feminist Art (TMIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-08-30
Duration (months): 24.0
Total project cost (EUR): 185464.32
EU funding (EUR): 185464.32
Participants: 1
Project status: CLOSED

The development of Israeli visual culture in the twentieth century was underscored by artists’ search for local roots, counterbalanced with their desire to dialogue with an international artistic arena. As in other settler societies such as the United States and Australia, the attempt to produce a distinguished idiom of Israeli modernism oscillated between "nativism" and "universalism"––two seemingly opposed tendencies that were actually interrelated. Indeed, the historiography of Israeli visual culture has emphasized the ongoing tension between local versus global/universal influences. Nevertheless, scholars continue to debate which sources shaped Israeli modernism, and what political implications followed the incorporation of Middle Eastern traditions, European Jewish heritage, or international avant-garde movements into an Israeli national style. The proposed study would contribute to such debates by investigating a medium that has received little scholarly attention––textiles. Textiles and the Making of Israeli Modernism: From the Zionist Bauhaus to Feminist Art (TMIM) will focus on textiles produced in Israel during the 1940s–1970s within three separate yet overlapping fields of practice: an art and craft academy, a government-owned fashion brand, and the fine art establishment. TMIM will draw and expand on recent scholarship that addressed the marginalization of textiles within art history due to its association with "low," commercial, or "feminine" work, as well as the innovative field of object-oriented anthropology that considers "things" as agents of cultural and social meaning. TMIM aims to establish the significance of a group of highly prolific artists-designers, all female, whose work has been entirely overlooked. It is precisely its position at the crossroads of art, craft, and commerce that makes the field of textiles fertile ground for examining the construction of modernist perceptions during this formative period of Israeli nation-building.

Keywords: textiles,israel,cross cultural influence,women artists,modernism
Synthetic Viral Nanosystem for Highly Efficient AAV Manufacturing for Gene Therapy (AAV-FACTORY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Gene therapy is one of the most innovative and fastest growing fields in the pharmaceutical industry. The first approved gene therapy utilized a recombinant AAV vector (rAAV), and dozens of additional rAAVs for gene therapy are presently in clinical trials. rAAV gene therapy drugs have been priced in the region of € 500’000 and above, which is partially a result of them being manufactured by highly complex processes combining multiple components, requiring 5-7 separate GMP production runs. We intend to introduce the first scalable, single-virus rAAV production platform to resolve this bottleneck. The resulting significant reduction of manufacturing complexity will both lower the price of future rAAV gene therapies, and also deliver additional, currently unaddressed or unaffordable rAAV treatments for genetic diseases into the clinic by providing scientists operating at the laboratory R&D stage with more user friendly and productive tools. The proposed project also develops for PoC purposes an rAAV gene therapy candidate to treat the devastating childhood congenital disease known as steroid resistant nephrotic syndrome SRNS.

Keywords: adeno associated virus aav,viral vector,gene therapy,synthetic viral nanosystem snv,recombinant production,manufacturing,upscaling
A non-surgical and long-lasting treatment to substantially reduce back pain (StayAble)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Stayble Therapeutics AB is a Swedish life science SME developing an injectable treatment (STA-363) for chronic low back pain (cLBP) caused by spinal disc degeneration. STA-363 aims to considerably reduce the patient´s pain in the long-term. CLBP affects the lives of over 50 million people in the EU and U.S., with the total costs for society in the U.S. alone estimated at 100 B$-200 B$ (80 B€ - 160 B€), making cLBP one of the costliest and most disabling conditions globally. Over two thirds of patients with discogenic cLBP are not helped by the conservative treatment options of painkillers and physiotherapy; and only a small fraction are eligible for a spinal fusion surgery, the last line of treatment. Stayble’s patent-pending solution STA-363 offers a cost-effective disease modifying long-term treatment option to bridge this gap in available treatment options. The treatment is currently in Phase Ib clinical trial with final results expected in Q3/2018. Stayble will lead the development of STA-363 through Phase II proof of concept study, and thereafter partner with pharma companies for further development and global commercialisation. The feasibility study, performed under this SME Phase 1 project, will focus on gaining in-depth market understanding on the patient side as well taking a better look at the potential partners and partnering models. The results will strengthen and provide future innovative direction for company’s business plan and commercialization strategy.

Keywords: degenerative disc disease,low back pain
Probabilistic Assessment of Reduction and Transfer of Natural Earthquake Risk (PARTNER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Seismic risk management in fast-growing populated seismic areas is a challenge for governments and communities in case of catastrophic events. Seismic resilience options are considered to mitigate risk, by either reducing the risk through vibration-control designs of risky assets, or by transferring the risk into the capital markets, through disaster financing options or (re)insurers. Both strategies require a good understanding of the seismic risk, which can be achieved only through thorough ground-motion uncertainty quantification and propagation to structural response, and accurate estimates of damage, cost and downtime estimates of the affected assets. The current proposal presents a compete framework to analyze the effects of resiliency measures on the overall risk of communities by (1) developing novel probabilistic model to characterize local seismic hazard by using site-specific records, (2) characterizing the exposed assets accurately at high resolution, (3) developing novel and efficient seismic vulnerability models consistent with the seismic hazard and (4) calculating probability distributions of seismic-performance metrics rather than just mean values for a better characterization of the risk. This methodology will be applied to study the risk reduction and transfer effects on communities. Seismic risk-reduction will be achieved through implementation of seismic control devices to structures and risk-transfer is achieved through financing mechanisms, such as catastrophe bonds and other parametric models, used to carry over risk to risk-takers.

Keywords: seismic resilience,earthquake engineering,seismic fragility,exposure,catastrophe modelling,risk assessment,disaster risk financing,probabilistic seismic hazard analysis
The role of maternal microbiota in offspring lung development and function (ProLung)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

In early life, interactions between our microbiota and our bodies are key elements to health and disease prevention. While it is known that microbiota drives development of the gut mucosa, it is unknown which influence microbiota has on the development of the lung in early life. I have recently discovered large biologically and statistically significant effects between maternal probiotic treatment during pregnancy, maternal gut microbiota changes and alveolar development in mouse offspring. This type of effect has never been shown before and modulation of microbiota with probiotic bacteria thus appears to support lung development and could possibly intercept lung diseases. With “ProLung”, I want to reveal the mechanisms behind this effect on lung development. I will do that by determining; the timing of the effect, which microbiota is more important and what genes are differently regulated in dams and their pups. I will show causation by transferring microbiota and phenotype to germ-free mice. Finally, as a “proof of concept”, I will develop and employ an oxygen driven disease model of infant lung dysplasia and show if modulation of microbiota can enhance breathing and could be used to intercept this early life lung disease. The proposed “ProLung” action will be conducted under world-class supervision at University of Copenhagen, Denmark with strong partners, in a highly cross disciplinary international collaboration with University of Oxford (UK), University of Michigan (US) and co-funded by the world second largest chemical company Dupont. I have a unique background and track record suited to perform the proposed research. Furthermore the action will allow me to pursue several training objectives that will be instrumental for my future career in the cross-section between academia and industry.

Keywords: mouse models of lung disease,lung,probiotics,microbiome transplants