Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Collective Action and Memory in the French Environmental Movement (CAMFEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 222047.2
EU funding (EUR): 222047.2
Participants: 1
Project status: CLOSED

This project investigates transformations in environmental protest strategies since the 1970s, placing them in the context of changing configurations of state power and legal and political norms. Undertaken within the CRAPE research centre on political mobilisation at the IEP in Rennes, the project focuses on the opposition to the construction of nuclear power plants in north-west France, comparing current mobilisations with the widespread opposition to reactor siting in the late the 1970s and early 1980s. The objectives are to (i) develop an updated approach to political opportunity, (ii) collect and provide empirical data for and theorise ‘judicial opportunities’, and (iii) embed movement strategies within an understanding of activist memory and identity. Empirical data will be gained through qualitative, actor-centred research, including the observation of meetings and a comprehensive series of semi-structured interviews with activists from current campaigns and those of the 1970s, and through local newspaper, police, and court archival searches. The data will enable us to explore the social, cultural, and political impacts over a generation of (i) norms of illegality and violence; (ii) the development of EC law and European institutions; (iii) the effects of global environmental change on the brokering of public consent; and (iv) the performance and representation of movement memory and identity in activist strategies. We anticipate that the findings will be valuable for the specific French case, and will further be testable across movements and states. The host will integrate the Fellow into the CRAPE research centre, and provide multi-disciplinary training in journalism methods and in interview fieldwork. The expected impact is enhanced career development: the training and collaborative experience will enable significant project/network funding bid development in the project’s final stage, preparing the Fellow for future international research leadership.

Keywords: social sciences,environmental politics,social movements,nuclear power,climate change,violence,legality,memory
Molecular-genetic approaches to study the role of FT in photoperiodic flowering of Arabidopsis (FT AND FLOWERING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 162161.0
EU funding (EUR): 162161.0
Participants: 1
Project status: CLOSED

Proteins related to FLOWERING LOCUS T (FT) strongly induce flowering of many plant species. In Arabidopsis thaliana FT is a component of the photoperiodic pathway and its transcription is activated under long days characteristic of summer. Recent studies showed that FT protein is expressed in the leaf vascular tissue and then moves through the phloem to the shoot apex, where it causes changes in gene expression that reprogram the shoot apical meristem to form flowers instead of leaves. Although transgenic experiments suggest FT protein is sufficient to induce flowering, it may nevertheless act together with other mobile components and genes induced by FT in the leaf might facilitate FT movement or function. In addition, molecular analysis of the pathways that regulate flowering-time in response to environmental signals suggests that many components of these pathways remain to be identified. This project proposes the use of molecular genetics and genomics approaches to reach three major objectives: (1) to identify genes involved in FT function or transport (2) to study the effect of the identified genes on flowering time and position them within the flowering pathway network (3) to study the effect of identified genes on FT transport by confocal microscopy. Preliminary results support the feasibility of the proposal, such as the identification of interesting genes whose expression is affected by FT in leaves and isolation of early-flowering mutants in genetic backgrounds null for FT activity. Training will take place at the MPI for Plant Breeding, Cologne and will complement the researcher`s existing skills in molecular biology by adding expertise in bioinformatic approaches, next generation sequencing and confocal microscopy. The technical expertise gained, the materials generated in the project and the expertise in project management obtained will assist the applicant in reaching his goal of starting an independent research group in his home country.

Keywords: flowering locus t,arabidopsis,photoperiod,flowering time,global transcriptome analysis,tiling array,next generation sequencing,forward genetics.
Role of Mitochondrial Physiology in Tumor Stem Cell Resistance to Chemotherapeutics (MITOCANCERSTEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-08-01
End date: 2012-07-31
Duration (months): 24.0
Total project cost (EUR): 147283.6
EU funding (EUR): 147283.6
Participants: 1
Project status: CLOSED

Although many advances in cancer research have heightened cases of long term survival, tumor re-growth is still a major concern. One hypothesis of the driving force behind tumor re-growth is the subpopulation of cancer stem cells found in varying types of tumors. Cancer stem cells have emerged as an important chemotherapeutic target over the past decade, as their ability to evade treatments provides a likely source for tumor re-growth. Like organs, tumors are composed of a mixture of cells at varying states of differentiation and arise from cells with the ability to proliferate indefinitely and differentiate into multiple lineages. In healthy organs, the cells responsible for organ development are stem cells, suggesting that tumors also have a subset of cells with stem-like characteristics known as cancer stem cells. Over the past decade, support for the existence of cancer stem cells has grown, suggesting that cancer stem cells are a driving force in tumorigenesis.This project is devised to investigate mitochondrial characteristics of cancer stem cells that allow them to survive the effects of chemotherapeutic drugs, especially those targeting apoptotic pathways. Our working hypothesis will be that the differential physiology of mitochondria in tumor stem cells and differentiated cells result into a different susceptibility to chemotherapeutics.To pursue the objective of the present work we will use mouse P19 embryonal carcinoma cells (TSC), which are a unique system on the basis that cancer stem cells can be compared with more differentiated cancer tumor cells in the same cell line under two different conditions. Preliminary data from the host group clearly demonstrates that mitochondrial differentiation accompanies cell differentiation. The consequences for cell metabolism and resistance to pro-oxidants, chemotherapeutics and mitochondrial inhibitors of the different mitochondrial subtypes are not known and constitute the basis of this proposal.

Keywords: mitochodria,oxidative stress,cell biology,anticancer therapy,tumor stem cells
To See or Not to See: The Metabolic Cost of Having Eyes and its Role in the Evolution of Vision (VISUALEYES COST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-10-01
End date: 2013-01-15
Duration (months): 24.0
Total project cost (EUR): 179169.4
EU funding (EUR): 179169.4
Participants: 1
Project status: CLOSED

The evolution and regression of vision in animals has long interested scientists, and researchers have strived to identify the proximate (how did eyes evolve or regress?) and ultimate (why did eyes evolve or regress?) explanations for the appearance and disappearance of eyes. This Marie Curie proposal will use the Mexican blind cavefish to test whether the metabolic cost of the eye has been a significant selective force in the evolution and regression of vision. The Mexican blind cavefish is model species used in developmental biology, and is useful in the study of visual evolution as it has eyed, surface-dwelling ecomorphs, and non-eyed, cave-dwelling ecomorphs. I will measure the energy demand (oxygen consumption rate) of the eye in eyed ecomorphs using both in vivo and in vitro techniques. In vivo oxygen consumption measurements of the eye will be performed on anaesthetised individuals using oxygen microsensors. The energetic demand of the eye will be compared to the whole body metabolic rate of eyed and non-eyed individuals to infer a metabolic cost of vision. The in vitro oxygen consumption measurements of isolated retina will be performed on a specially constructed device where the incoming light intensity can be varied. The retinal oxygen consumption rate will be measured over a range of light intensities to quantify how the cost of the eye changed as Mexican blind cavefish diversified from surface habitats into caves. It is hypothesised that the energy requirements of the retina will be higher in the dark than that in the light. This project will offer an energetic explanation as to why eyes would be disadvantageous in the absence of light, and why selection would act to regress eyes in dark habitats. By understanding the metabolic cost of eyes, we can also learn about the energetic advantages that must have been gained by evolving vision.

Keywords: natural sciences,evolution,regression,vision,energetics,mexican blind cavefish
Space-based analysis of the relationship between vegetation functioning and atmospheric CO2 and CH4 greenhouse gases (SPACECO2VEG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-02-01
End date: 2012-03-31
Duration (months): 14.0
Total project cost (EUR): 165540.8
EU funding (EUR): 165540.8
Participants: 1
Project status: CLOSED

Vegetation physiological activity and atmospheric CO2 and CH4 greenhouse gases are key factors in the regulation of the carbon cycle. Atmospheric CO2 is linked to vegetation functioning by a bidirectional process in which vegetation modulates the seasonal amplitude of CO2 concentration through photosynthesis and respiration processes, while CO2 affects vegetation growth by the so-called fertilization process. In addition, the role of plants as a non-negligible CH4 source is currently under active discussion. The research presented in this proposal is aimed to the analysis of the correlation between green vegetation functioning and atmospheric CO2 and CH4 concentrations at regional and global scales by the exploitation of satellite data. Data acquired by the Greenhouse gases Observing SATellite (GOSAT) launched in January 2009 by the Japanese Space Agency will be used to derive space and time-resolved atmospheric and vegetation variables for this multidisciplinary analysis. The quantitative and global assessment of (a) the link between vegetation functioning and atmospheric CO2 concentration and (b) CH4 emission by plants are the two main goals of this proposal. The researcher would benefit from the broad experience in the field of the host Atmospheric, Oceanic and Planetary Physics department of the University of Oxford for the achievement of the proposed research objectives. The topic of the space-based assessment of the carbon cycle is considered of major importance by European research directives. In particular, this topic perfectly fits into the Environment (including climate change) and Space themes of the Cooperation specific program of the EU-FP7, and into the Coordination Action COCOS (COordination action Carbon Observation System).

Keywords: earth science,ozone and atmospheric composition,environmental physics,carbon cycle (climate change),greenhouse gases (climate change),remote sensing
Shaping Conical Intersections for Intramolecular Proton Transfer (SCIIPT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-20
End date: 2012-09-19
Duration (months): 24.0
Total project cost (EUR): 172740.8
EU funding (EUR): 172740.8
Participants: 1
Project status: CLOSED

Excited-state intramolecular proton transfer (ESIPT) - where proton transfer occurs after the absorption of a photon - is an important topic for the understanding of photoreactions in organic systems. The central aim of this proposal is to apply a unique combination of novel computational tools to understand such processes. We will study methyl salicylate (MS), a ‘floppy’ molecule with a slow proton transfer. Computationally, our first objective will be to map out the reaction paths and conical intersection seams accessible to excited states, characterised as critical points linked by minimum energy paths that preserve the degeneracy of the two states. Having determined the molecular geometries at which decay to S0 takes place, we will be able to suggest strategies to control the dynamics on the excited state. Multiple decay pathways make MS and related systems suitable for coherent control investigations; experiments which are planned by the experimental group of Prof. Fielding at University College London. MS is a challenge for quantum methods in which the dynamic electron correlation is cruzial for obtaining accurate excitation energies and realistic barrier heights. Our second objective is to compare the CASPT2 approach - which the applicant knows from his PhD- with the RASSCF one. Calculating CASPT2 energies at CASSCF geometries is a state-dependent approximation: there is the potential with RASSCF to go beyond this. There is scope to develop the projects further including environmental effects (QM/MM), or to study quantum dynamics. This fellowship proposal combines the experience of excited state calculations developed by the applicant with the complementary experience in computational methods of the host group. It will lead to new insights into the mechanism of ESIPT and greater experience in crossing seam mapping. Furthermore, there is scope for developing long-term collaborations between both computational &amp; experimental groups in the UK &amp; Spain.

Keywords: theoretical chemistry,photochemistry,non-adiabatic processes,proton transfer
TRansferring ACademic Knowledge (TRACK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-01
End date: 2011-11-30
Duration (months): 18.0
Total project cost (EUR): 125030.6
EU funding (EUR): 125030.6
Participants: 1
Project status: CLOSED

Over the past thirty years, Knowledge Transfer Activities (KTA) have come to be considered as a natural stage in the evolution of the modern university, in addition to the more traditional mandates of education and research. KTA by academics are accomplished in different forms. Some of them, more discovery-driven, are characterized by the enforcement of intellectual property right, such as patenting, licensing and creation of new business based on patent. Some others, such as consulting and collaboration with industry, are more construction driven and are undertaken outside the Intellectual Property system (IP-system). The vast majority of studies on KTA examine entrepreneurial activities generated as a result of a formal disclosure process that occurs within the IP-system. Thus, very little is still known on the breadth and depth of KTA, on the impact that these activities have on academics&apos; research productivity, as well as on the effectiveness of university support mechanisms in fostering them. In order to fill part of this void, aim of TRACK is to: a) gather new primary and secondary data on KTA undertaken by a representative sample of the academics in the U.K.; b) complement this information with empirical evidences on their research productivity and highlight the trade-offs (if any) between KTA and research; c) identify the support mechanisms put in place by universities as well as the TTOs’ business models, spotting the best practices in the support of KTA. Adopting a multilevel approach and relying on advanced econometric technique, TRACK will characterize the depth and breadth of KTA undertaken by academics in U.K, assessing the impact that KTA have on individuals’ research productivity and exploring the impact that different institutional characteristics have on KTA undertaken by academics. Results will have implications for efforts to develop and test theories of academic entrepreneurship, as well as efforts to develop science-policies.

Keywords: knowledge transfer,academic entrepreneurship,individual characteristics,multi-level research design
Connectivity in Complex Networks of interacting stochastic nonlinear systems. Applications in neuroscience (COCONET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2011-03-01
End date: 2014-02-28
Duration (months): 36.0
Total project cost (EUR): 205983.2
EU funding (EUR): 205983.2
Participants: 1
Project status: CLOSED

The context of the project is the study of networks of interacting nonlinear systems with application to neuroscience. The project adresses two timely and innovative questions: - Are we able to estimate the connectivity/directivity graph from the observation? - What is the influence of the network topology on the information processing of the network? To answer the questions we develop four tracks of research: 1- Practical inference for connectivity and directivity in complex networks (statistics, kernel methods, information theory) 2- Synthesis of multivariate signals interacting according to a complex network. (stochastic processes) 3- Information processing by pooling networks (information theory, modeling of neural of spiking neurons) 4- Taking into account directionality : directed information theory in neural networks (feedback/feedforward in neural networks) Outgoing phase of the project hosted by the University of Melbourne, Dept. of Mathematics and Statistics with collaboration with the neuroengineering group and the Center for Neural engineering. Return phase hosted by CNRS/ GIPSAlab, Grenoble, France. Expected outcomes and benefits for the EU includes: 1- The design of a practical methodology for inference of connectivity/directionality between signals with nonproperties (nonstationarity, nonGaussianity, ...). Designed for neuroscience applications, but easily extended to other scientific domains. 2. Enriched understanding of the influence of the topology of networks onto information processing. 3. Enriched understanding of the importance of feedback/feedforward onto the information processing of neural networks. Anticipated related outcome includes improvements in prostheses, brain computer interfaces, better understanding in diseases such as epilepsy. Expected experience acquired in management of mulidisciplinary project through the collaboration with Math/stat dept and Center for Neural Engineering

Keywords: information theory,signal processing,statistics,nonlinear systems,computational neuroscience,complex networks
Analytic approaches to planar growth processes (CROISSANCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-11-08
End date: 2013-08-07
Duration (months): 33.0
Total project cost (EUR): 222547.2
EU funding (EUR): 222547.2
Participants: 1
Project status: CLOSED

Many important phenomena reveal stochastic geometrical objects and shapes. Among them are fluctuating domain boundaries in statistical mechanics, growing patterns in non-equilibrium processes, and fluctuating surfaces studied in random matrix theory. These geometrical objects naturally arise in the theory of 2D growth processes, disordered systems and random media. In many interesting cases they are fractal in nature. The project focuses on a wide class of processes involving stochastic geometry in two dimensions and the related deterministic objects arising in free-boundary problems, such as Laplacian and elliptic growth. In spite of discovery of many deep connections between the theory of moving interfaces in two dimensions to a number of modern branches of mathematics such as advanced complex analysis, deformations of Riemann surfaces, integrable systems and theory of random matrices, there are many important questions to be addressed. For instance, complete analytic description, classification and universality of random growth processes and their deterministic counterparts on the plane as well as theory of singularity formation and regularisation are far from being complete. The project goal is to apply novel analytical and numeric techniques and combine ideas from different disciplines, in order to attack the above problems. Remarkable developments in Laplacian and elliptic growth due to recent achievements in theory of integrable systems and random matrices as well as revitalization of the study of 2D critical phenomena as a stochastic evolution of geometry due to recent discovery of the Stochastic Loewner Evolution make feasible further significant advances in the field. Multi-disciplinarity of the present project is addressed to combine the most recent advances in the named adjacent topics to shed light on the nature of fascinating interaction amongst phenomena both of pure physical and mathematical origin.

Keywords: mathematical physics,applied mathematics,stochastic processes,free boundary problems for pde,growth processes