Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Natural Food formulation for the prevention and treatment the Obesity and Metabolic syndrome obtained with herbal extracts (INNOPREFAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-10-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

After a four-year program of research and development MONTELOEDER has identified highly active components in well-known and safe herbal extracts (Hibiscus sabdariffa and ; Lemon verbena) that preclinical results shows to modulate triglyceride accumulation, oxidative stress and inflammation in insulin-resistant adipocytes and their capacity to decrease body weight, serum cholesterol and triglycerides levels and hepatic steatosis signs in a hyperlipidemic mouse model subjected to high-fat diets. Based on this results, MONTELOEDER will put in the market a natural functional food ingredient, based on the selected combinations of the two herbal extracts that exhibit synergy in their ability to activate AMPK –enzyme, for the treatment and prevention of overweight and conditions associated with Metabolic Syndrome (MetS). The new formula is characterized because of its high polyphenolic content, high water solubility and produced under the main “Green Extraction” principles. One of the most evident health concerns worldwide is the obesity and other pathologies related with the metabolic syndrome (MetS), which is is a growing epidemic throughout the world. It has been estimated that in people over 50 years of age, metabolic syndrome affects more than 40% of the population in the United States of America and nearly 30% in Europe. And this number is expected to double over the next 15 years. There are economical and health issues in the necessity for developing food ingredients for the prevention and/or treatment the obesity and Metabolic syndrome. Despite the large number of products classified as functional foods ingredients, there are only two natural products targeted to MetS, which are not allowed in Europe and U.S.A. markets. The new product could reach a sales volume during 2017 of 75,000 daily doses, what would be 0.04% of the global market (200million people), and with an important growth impact on the invoicing and Company profit.

Keywords: natural functional food ingredient,metabolic syndrome,overweight,ampk enzyme,herbal extracts,hibiscus sabdariffa,lemon verbena
Internet of Things Air Tester as a new standards based wearable monitoring station for personalized indoor and outdoor air quality real-time assessment (habITAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Portugal
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We are a Portuguese SME, which provides Indoor Air Quality (IAQ) and Sick Building Syndrome (SBS) audits, and Environmental analysis services. We have been working in the development of a disruptive way to improve the monitoring of indoor and outdoor air quality using the Citizen Observatories model as the strategic approach for our business. To this end we aim to prototype, test and commercialise an IoT wearable air quality monitoring system for both professional auditors and citizens. IAQ audits are a key tool to prevent health risks and spur productivity, while supporting energy efficient measures. Auditing IAQ involves various unknown variables which impact on the cost, the time and the effectiveness of the audit. We have a clear and disruptive business opportunity, as an IoT IAQ system that would enable easy and fast monitoring of physico-chemical IAQ indicators in whole buildings using its own occupants as mobile monitoring stations, will increase the efficiency and effectiveness of audits at a lower cost. habITAT addresses priorities of the EC aligned within Europe 2020 Flagship Initiatives , the Environment Action Programme , the Eco-innovation Action Plan and the EU Expert Group on Indoor Air Quality. Objectives of the feasibility study: 1) Examine the technical feasibility of the solution to achieve a good problem-solution fit that will enable jump-start product adoption, and bridge innovators with early adopters; 2) Examine the commercial feasibility to achieve a good product-market fit that will enable bridging early adopters with early majority in the product life cycle.

Keywords: internet of things,indoor air quality,sick building syndrome,citizen observatories,wearable,device,ogc standard,iee 1451 standard,iee 802 standard,fiware
Smart Composites for Additive Technology (SCAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Goal of the SCAT feasibility study proposal is to complete the technical, commercial and financial assessment of a new additive manufacturing technology which has demonstrated to have the potential to disrupt dentistry. In the common practice there are a lot of materials that can be used to manufacture denture superstructures: Zirconium oxide, Titanium, Chrome-cobalt. An alternative to metal supported and or ceramic restorations in removable and fixed dentures is provided by Fiber Reinforced Components, which represent a low-cost alternative to metal-alloy, metal–ceramic, all-ceramic restorations, and providing a superior resistance to fractures. Today, all the commercial 3D printers for dental applications do not make use of Fiber Reinforced Composite (FRC), all of them are using metallic materials, ceramic and resin materials. Thus, the current practice to fabricate FRC dentures suffer of serious drawbacks due to the specific manufacturing methods: either loss of the mechanical proprieties and production of a lot of waste materials, or when hand-made the result is imprecise and dependent by the operator. The SCAT project aims at overcoming the today fabrication limits by additive manufacturing using FRC materials.

Keywords: robotics and healthcare,advanced additive manufacturing,mass customisation
Phylogenetic association mapping and its application to secondary metabolite variation in Brassicaceae species (INTERACT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 1494214.0
EU funding (EUR): 1306714.0
Participants: 2
Project status: SIGNED

During the past years, great progress has been made in connecting phenotypes to genotypes based on within-species variation. However, the more dramatic variation that can be found between species has not been explored for phenotype/genotype associations so-far. Using classical genetics to mine between-species variation is mostly impossible, because crosses between distinct species hardly work and their genomes are usually highly rearranged. The goal of this project is to develop unprecedented genomics-based methods for inter-species (phylogenetic) association mapping, which can find signals even in highly re-arranged genomes of different species. To ensure that these methods are also useful in practice, we will apply them to the variation in secondary metabolites within the Brassicaceae plant family. Secondary metabolites are highly variable, genetically controlled, easy to measure and have broad application in cancer prevention, pest control and food design. Given the great potential of phylogenetic association mapping in general and secondary metabolites in particular, our work promises to be ground-breaking and have profound impact on many different fields of genetic research. Specifically, our work plan includes the following points: I) We will develop strategies for phylogenetic association mapping and implement them in publicly-available software. II) We will establish a panel of inbred lines from ~200 Brassicaceae species and generate whole-genome assemblies for each of them. III) We will exemplify the usefulness of phylogenetic association mapping by correlating the diversity of secondary metabolites to the differences in the respective genomes and validate the results by transforming or mutating candidate genes in appropriate species.

Keywords: association mapping,association statistics,inter species variation
Quantifying the global patterns and trends of the illegal wildlife trade: from artificial intelligence to financial market analysis (WILDTRADE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Finland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 1499900.0
EU funding (EUR): 1499900.0
Participants: 1
Project status: SIGNED

Illegal wildlife trade is one of the major threats driving the global extinction crisis. Despite political will to halt the problem, the magnitude and scale of illegal wildlife trade have been relatively poorly studied compared to other threats affecting biodiversity conservation. Lack of data and complexities in determining illegal trade volumes and the availability of illegal wildlife products in the marketplace have thus far limited progress in research. The socio-ecological and economic drivers underlying the illegal wildlife trade remain unclear. The goal of this project is, for the first time with this extent and detail, to quantify global patterns and trends of the illegal wildlife trade and how market forces shape them. The deluge of information from digital technologies in the ‘Information Age’ combined with the development of new artificial intelligence techniques will allow me to quantify the global patterns and trends of the illegal wildlife trade at an unprecedented spatio-temporal detail. Illegal wildlife trade is booming online and I hypothesize that Big Data mined from social media platforms can help identify which wildlife products are traded and to assess motivations behind the trade. I plan to combine such novel, geotagged and temporally accurate, information with other spatio-temporal datasets on law enforcement and human pressure, to identify the global hotspots under pressure from illegal wildlife trade and quantify the flow of wildlife products between these hotspots and the marketplaces in demand countries. I also plan to investigate how pervasive market forces underline the global patterns and trends of the illegal wildlife trade. The proposed research will provide (i) novel concepts and methods for conservation science and identify (ii) species and areas most under pressure from illegal wildlife trade globally, (iii) the trade routes and flow of wildlife products; and (iv) the drivers underlying the illegal wildlife trade.
OncoSeq: an innovative single-cell system for immunomonitoring (OncoSeq)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany,France
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-11-01
End date: 2018-10-31
Duration (months): 12.0
Total project cost (EUR): 150000.0
EU funding (EUR): 41250.0
Participants: 2
Project status: CLOSED

Host immunity plays a central and complex role in tumour progression, and the quality and quantity of immune infiltrate at the tumour site is used as a prognostic marker of cancer progression. Therefore, detailed single-cell analysis of tumor infiltrating immune cells, and ultimately liquid biopsy of circulating immune cells, is of vital importance for the development of new and improved immunotherapy strategies, and for diagnosis, prognosis, patient stratification and follow-up. We propose in OncoSeq to adapt the droplet barcoding microfluidics system, an output from the ERC EVOEVO project, to develop a novel “molecular cytometer” for high-throughput transcriptomic and phenotypic analysis, at the single-cell level, of tumor infiltrating or circulating immune cells. Readout of genotype and phenotype will be entirely based on next generation sequencing (NGS) allowing higher phenotypic multiplexing capacity (100s of phenotypic markers) than fluorescence (Flow cytometry) or mass spectrometry (CyTOF) based approaches (≤40 markers) and simultaneous RNA-sequencing (RNA-seq), allowing the creation of high-resolution phenotype-transcriptome maps for tens of thousands of single cells. This will be a powerful tool for cancer prognosis, clinical decision making and monitoring of disease progression, especially in the context of immunotherapy. So far, no such diagnostic instruments, enabling high-throughput single-cell phenotypic and transcriptomic analysis, exist. The technology developed will be transferred to our industrial partner through licensing for internal development of novel immunotherapies. In addition, once the prototype system is fully validated, we plan, with our industrial partners, to create a new company specialising in the sale of instruments and associated consumables for clinical single-cell immuno-monitoring for the research and clinical oncology markets.

Keywords: single cell,phenotyping,transcriptomic,next generation sequencing,droplet based microfluidics,immunomonitoring,immunooncology
Support for the Intergovernmental Panel on Climate Change (IPCC) to facilitate the preparation of its next Assessment Report (IPCC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Coordination and support actions
Countries involved: Switzerland
Call: H2020-Adhoc-2014-20 (H2020-Adhoc-2014-20, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 2634537.5
EU funding (EUR): 700000.0
Participants: 1
Project status: CLOSED

The Intergovernmental Panel on Climate Change (IPCC) is the key global climate science-policy interface, underpinning European and international climate change policy-making and is the leading global body responsible for the scientific assessment of climate change. In preparation of the next Assessment Report, support will be provided to increase the participation of experts from developing countries and EU countries, should their governments be unable to provide appropriate funding, consistent with IPCC practices, to the IPCC process and enhance visibility of the IPCC goals in Europe.

Keywords: climate change,physical science,impact,adaptation,vulnerability,mitigation
PHAGENET: PHAge GEnetic NETworking in the microbiome (PHAGENET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1999988.0
EU funding (EUR): 1999988.0
Participants: 1
Project status: SIGNED

Horizontal gene transfer (HGT) is one of the primary forces driving rapid adaptation and long term evolution of complex microbial communities such as the human microbiome. The same process is involved in the dissemination of virulence and antimicrobial resistance genes and emergence of “superbugs”. The precise mechanisms and role of HGT in the structure and function of the microbiome remain largely unexplored. Bacteriophages are ubiquitous and highly abundant members of the human microbiome, accounting for ~5% of total microbial DNA. Many of them, such as crAssphage, are highly prevalent and have evolved complex relationships with their microbial hosts. At the same time their role in microbiome composition and function is unclear. Recently we observed the accumulation of considerable amounts of bacterial genomic DNA in the phage-encapsulated fraction of human faeces (up to 50% in some instances). Analysis of this chromosomal fraction reveals that it does not appear to be due to contamination, but rather represents phage-mediated mobilisation and transfer (transduction) of DNA from specific bacterial taxa and specific genomic regions. PHAGENET argues that phage-mediated transduction plays a significant role in the genetic plasticity of the human microbiome, and that the phageome provides individual microbes with access to a wider pangenome and enables dissemination of genes both within and across individual human microbiomes. I propose to thoroughly test this hypothesis at molecular, cellular and organismal levels. This will involve an array of approaches, including long-read high-throughput sequencing, faecal chemostat models, random transposon insertion libraries in gut bacteria and animal models. By addressing an important gap in our understanding of the microbiome, PHAGENET will impact across the research areas of microbiology, virology, gastroenterology, evolutionary ecology and epidemiology.

Keywords: phageome,virome,bacteriophages,crassphage,horizontal gene transfer,phage transduction,mobile genetic elements,human gut microbiome,pangenome
Endothelial RNA Modifications in Vascular Homeostasis and Disease (MODVASC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-06-01
End date: 2024-03-31
Duration (months): 70.0
Total project cost (EUR): 1499250.0
EU funding (EUR): 65477.5
Participants: 2
Project status: SIGNED

Endothelial cells cover the entire arterial and venous tree, and play a pivotal role in vascular and organ homeostasis. In general, cardiovascular risk factors induce endothelial cell activation towards a pro-inflammatory phenotype leading to atherosclerosis, a major cause of mortality in the Western world. Understanding the mechanisms that orchestrate endothelial cell functions and response to environmental stimuli is essential for the discovery and development of novel biomarkers and therapeutic strategies in vascular disease. RNA base modifications increase the RNA alphabet from the 4 canonical nucleotides to more than 140. Adenosine methylation at the N6 position (m6A) is the most prevalent RNA modification in eukaryotic mRNA and is catalyzed by a multiprotein methyltransferase complex. Accumulating recent evidence suggests that m6A RNA methylation is a critical posttranscriptional regulator of RNA metabolism. In preliminary unpublished work we have identified methylated RNA targets, which may critically regulate endothelial cell functions. Since the impact of m6A RNA methylation on vascular function is completely unknown, MODVASC aims to explore the role of m6A RNA methylation in vascular growth, homeostasis and disease. By m6A-RNA immunoprecipitation followed by RNA-sequencing we will identify the transcriptome-wide m6A RNA methylation in endothelial cells under basal and stress conditions. With the help of advanced molecular biology and biochemical methods, we will describe in single nucleotide level the impact of m6A RNA methylation on mRNA fate and RNA-protein interactions and define its functional consequences in endothelial cell functions. In vivo studies will consolidate the impact of endothelial RNA methylation on vascular growth and homeostasis as well as its contribution to atherosclerosis. Finally, MODVASC will evaluate the clinical relevance of our findings in patients with cardiovascular disease.

Keywords: endothelial cells,mrna stability,rna modifications,vascular barrier function,vascular disease,atherosclerosis