Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Middle East Research and Innovation Dialogue (MERID)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Iran, Islamic Republic of,Iraq,Germany,Spain,Italy,Egypt,Italy,Belgium,Jordan,Palestine, State of,Greece,Slovenia,Lebanon,United Kingdom
Call: Encouraging the research and innovation cooperation between the Union and selected regional partners – proposals targeting Black Sea, Middle East, Africa (H2020-INT-INCO-2014, 2014)
Start date: 2015-01-01
End date: 2018-06-30
Duration (months): 42.0
Total project cost (EUR): 999750.0
EU funding (EUR): 999750.0
Participants: 14
Project status: CLOSED

The MERID project (Middle East Research and Innovation Dialogue) proposes a comprehensive action to intensify and encourage research and innovation cooperation between the EU and the Middle East region, directly involving partners from Egypt, Iran, Iraq, Jordan, Lebanon and Palestine, directly involving partners from Egypt, Iran, Iraq, Jordan, Lebanon and Palestine. The project intends to build upon the experience carried out in countries of the region that have already participated in the previous framework programmes, and therefore are at a relatively advanced stage of research cooperation with Europe, like Egypt and Jordan. Attention is paid to calibrating in the most appropriate way the intervention logic of the project, adapting actions to the specific needs of the target countries and their research constituencies. The needs of Iran and Iraq will for sure prove different from those of countries where cooperation with the EU has a proven track record behind. The project is the first attempt to systematise support to the policy dialogue and involvement of research communities of Iran and Iraq in the H2020 programme, as well as an initiative that seeks to give continuity to collaboration frameworks already established between the EU and Middle East countries. The project has high potential to deliver long-lasting impact and structuring effects on cooperation between the EU and the Middle East region. It focuses on enhancing direct cooperation among researchers and on laying or consolidating preconditions, in the region, fostering joint research projects and initiatives with the EU, establishing optimal framework conditions for international cooperation and increasing coordination between policies and programmes. These objectives will be achieved through series of different on-line and in-person activities, among which are meetings of researchers, brokerage events, info-days, training and coaching, webinars and other tools, relevant for this project proposals.

Keywords: researchandinnovation cooperation,middle east science diplomacy,eu middle east policy dialogue
Uncovering New Phenomena at the TeV Scale With Top Quarks (NPTEV-TQP2020)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy,United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1971841.0
EU funding (EUR): 1581831.12
Participants: 3
Project status: CLOSED

Our understanding of the subatomic world and of the very fabric of the space-time is encompassed in a theory which is the result of all past experimental observations and theoretical developments: the Standard Model of Particle Physics. Yet cosmological observations and theoretical arguments lead us to conclude that new phenomenology, new particles, forces, or a new space-time structure is waiting to be uncovered. Naturalness of the recently discovered Higgs boson suggests that new phenomena should appear at the tera-electronvolt (TeV) scale, and will be accompanied by modifications to the dynamics of the heaviest elementary particle known: the top quark. The aim of this proposal is to perform five measurements involving top quarks with the data that will be collected by the ATLAS experiment at the upcoming Run II (2015-18) of the Large Hadron Collider (LHC): the top quark mass, the CP violation in B hadron decays from the top, the top-Z boson couplings, the search for the top's Flavour Changing Neutral decays, and the search for heavy resonances decaying to top pairs. While measuring these properties is nothing new, the measurements are performed coherently using novel techniques beyond state-of-the-art to push the boundaries on the sensitivity of the limited Run II data, hence allowing the discovery of new phenomena at the LHC before 2020.

Keywords: atlas,top physics
Optimized Mesophilic Anaerobic Digestion Mixing (OptiMADMix)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-05
End date: 2018-01-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The aim of this innovative Fellowship is to provide a robust numerical framework, based on novel developments in the fields of CFD and biokinetic modelling, to optimize mesophilic anaerobic digester (MAD) performance, by reducing energy consumption whilst maximising biogas production. By 2030 the world will have to produce 50% more food and energy and 30% more water. Consequently, most countries are implementing programs to reduce carbon emissions and enhance renewable energy production. MAD is the most widespread technology for the treatment of sewage sludge, the by-product of sewage treatment. This natural process uses bacteria to break down biodegradable material and produces a biogas rich in methane. The current drive to maximise energy recovery means that biogas from MAD is increasingly harnessed by combined heat and power technology. Thus, there exists the need to optimise digester performance to maximize energy recovery. The benefits of improved performance go beyond CO2 reductions, as they will facilitate environmental improvements, reduce operating costs and improve the financial performance of the European and global wastewater industry. The challenge is to improve digester control to minimize excessive mixing, so eliminating additional, unnecessary environmental and financial costs whilst maximising biogas output. We will simulate for the first time the complex relationships between hydrodynamic and microbiological processes in a MAD environment, whilst also recognising the potential for grit sedimentation within digesters. We will extend significantly previous work and use coupled CFD/MAD modelling as an innovative and robust technique to monitor and control the hydraulic and biochemical performance of MAD. Meeting the project aim will deliver an appropriate methodology to improve MAD design and control, thereby offering tangible environmental and financial benefits and assisting the meeting of EU Directive requirements.

Keywords: anaerobic digestion,computational fluid dynamics,biokinetic modelling,energy,wastewater,treatment
Genetic and Lifestyle Origins of Inflammation in Depression (GLOID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2016-10-31
Duration (months): 18.0
Total project cost (EUR): 133199.11
EU funding (EUR): 133199.1
Participants: 2
Project status: CLOSED

Depression produces substantial societal costs. Its cause is unknown and treatments are suboptimal. Inflammation may be involved in depression. People with depression have elevated levels of inflammatory mediators in the blood, although it is unclear whether the source is genetic, environmental, or some interaction. A likely environmental source is unhealthy lifestyle behaviours. To progress the field, studies must more directly test the causal status of the inflammatory hypothesis of depression; specifically, whether inflammation-related genetic polymorphisms or whole polygenic risk scores interact with unhealthy lifestyle in depression and its remission. I will address these unanswered questions in a Marie Skłodowska-Curie European Fellowship with Professor Penninx’s research group at VU University Amsterdam; world-leaders in the investigation of psychobiological causes of depression. I will collaborate with experts in genetic epidemiology and the inflammatory hypothesis of depression and complete sophisticated statistical analysis of data from the longitudinal Netherlands Study of Depression and Anxiety (NESDA; PI Professor Penninx). It will result in at least four peer-reviewed research articles, related conference presentations, and opportunities to more broadly disseminate the findings. Undertaking this research along with formal training and mentoring will enhance my academic profile, scientific experience, and content expertise in the psychobiological causes of depression, to enable me to develop into an independent, leading researcher. The proposed research contributes to the EU priority of addressing “societal challenges” to improve lifelong health and wellbeing of all. Providing evidence for the contribution of genetics, inflammation and unhealthy lifestyle to depression will provide opportunities for identifying people at risk of depression, treating depression, and developing individual and public health prevention strategies.

Keywords: determinants of disease,unhealthy lifestyle,depression
Personalised Airport Systems for Seamless Mobility and Experience (PASSME)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Ireland,Italy,Greece,Netherlands,Netherlands,United Kingdom,Portugal
Call: Seamless air mobility (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 4639086.25
EU funding (EUR): 4631211.75
Participants: 12
Project status: CLOSED

PASSME aims to deliver industry-driven, passenger-centric novel solutions (up to TRL6) for passengers, airports and airlines to address the anticipated increase in demand for commercial flights in Europe by 2050. The goal is to reduce travel time by at least 60 minutes by integrating information between all stakeholders and transforming airport and aircraft operations and interiors to make the passenger journey time efficient, seamless, robust and accessible. This requires significant breakthrough solutions, such as: a real-time passenger-centric system for managing passenger flows that use input from the airport and passenger to provide predictive analytics on passenger flows 20-30 minutes ahead of time; a passenger independent system for managing luggage flows that reduce the time in arrival/departure airports by at least 30 minutes and increases the control passengers have over their luggage; radically redesigned passenger-centric airport and airplane processes and facilities that enable highly personalised and less stressful experience through key touch points (check-in and boarding); and a personalised device and smartphone application that measures physiological/psychological state and links with airport/airline services to provide relevant and timely information to support the passenger in decision-making. The research institutes (TUD, UNott, ICCS, TUHH, NLR, DLR) with interior design partners (Alma, Optimares) and communication experts (CARR) will work closely with Amsterdam and Hamburg airport clusters and KLM airlines to drive the user-centred design and evaluation methodology; to ensure the success of the solutions and that benefits will be shared with passengers, airlines and airports to have the necessary impact on the air transport system. Linking with the Airport Council International Europe (a selection of the 450 airports) and airport service SMEs will guarantee the results will have the maximum dissemination and exploitation across EU industries.

Keywords: human factors,passenger centric,passenger flow,luggage flow,seamless,time efficient,less stress,airport interiors,smart boarding,personalised information,personalised experience
The role of three-dimensional genome architecture in antigenic variation (3D_Tryps)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 1498175.0
EU funding (EUR): 1498175.0
Participants: 1
Project status: SIGNED

Antigenic variation is a widely employed strategy to evade the host immune response. It has similar functional requirements even in evolutionarily divergent pathogens. These include the mutually exclusive expression of antigens and the periodic, nonrandom switching in the expression of different antigens during the course of an infection. Despite decades of research the mechanisms of antigenic variation are not fully understood in any organism. The recent development of high-throughput sequencing-based assays to probe the 3D genome architecture (Hi-C) has revealed the importance of the spatial organization of DNA inside the nucleus. 3D genome architecture plays a critical role in the regulation of mutually exclusive gene expression and the frequency of translocation between different genomic loci in many eukaryotes. Thus, genome architecture may also be a key regulator of antigenic variation, yet the causal links between genome architecture and the expression of antigens have not been studied systematically. In addition, the development of CRISPR-Cas9-based approaches to perform nucleotide-specific genome editing has opened unprecedented opportunities to study the influence of DNA sequence elements on the spatial organization of DNA and how this impacts antigen expression. I have adapted both Hi-C and CRISPR-Cas9 technology to the protozoan parasite Trypanosoma brucei, one of the most important model organisms to study antigenic variation. These techniques will enable me to bridge the field of antigenic variation research with that of genome architecture. I will perform the first systematic analysis of the role of genome architecture in the mutually exclusive and hierarchical expression of antigens in any pathogen. The experiments outlined in this proposal will provide new insight, facilitating a new view of antigenic variation and may eventually help medical intervention in T. brucei and in other pathogens relying on antigenic variation for their survival.

Keywords: genome architecture,antigenic variation
Towards programmable cyber-physical systems: a symbolic control approach (PROCSYS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1266731.0
EU funding (EUR): 1266731.0
Participants: 1
Project status: SIGNED

Cyber-physical systems (CPS) consist of computational elements monitoring and controlling physical entities. The main objective of the PROCSYS project is to propose a general framework for the design of programmable CPS that will allow engineers to develop advanced functionalities using a high-level programming language for specifying the behaviours of a CPS while abstracting the details of the physical dynamics. Controllers enforcing the specified behaviours will be generated from a high-level program using an automated model-based synthesis tool. Correctness of the controllers will be guaranteed by following the correct by construction synthesis paradigm through the use of symbolic control techniques: the continuous physical dynamics is abstracted by a symbolic model, which is a purely discrete dynamical system; an interface consisting of low-level controllers is designed such that the physical system and the symbolic model behaves identically; a high-level symbolic controller is then synthesized automatically from the high-level program and the symbolic model. We will develop a high-level programming language, based on the intuitive formalism of hybrid automata, which will enable to specify a rich set of behaviours while enabling the development of efficient controller synthesis algorithms. The project will also tackle the two main bottlenecks in the area of symbolic control, which will enable its use in challenging real-life applications. Firstly, scalability of symbolic control will be achieved by the computation of more compact symbolic models and by controller synthesis algorithms that require only partial exploration of the symbolic models. Secondly, robustness will be ensured at all levels of control by developing novel algorithms for the synthesis of robust interfaces and of symbolic controllers. The algorithms developed in the project will be implemented in a symbolic control toolbox, which will enable the use of our approach by systems engineers.

Keywords: hybrid dynamical systems,symbolic control
Innovative and worldwide unique heat pump based condensation drying technology for drying and preservation of food products (AIRGENEX-food)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-10-01
End date: 2019-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Harter GmbH (Harter) was founded in 1991 and is still a family-owned company. Harter is Europe-wide known as specialist for heat pump based condensation drying systems, which are applicable in various sectors. By the companies’ unique expert knowledge and the high innovative strength, Harter developed to one of the most innovative companies for drying systems and gained an excellent reputation in recent years. Within the European society, conscious and healthy nutrition as well as gentle and sustainable processing and preservation are becoming increasingly important. To perfectly meet this trend, Harter developed the worldwide unique AIRGENEX®food chamber drying system for a reliable, gentle and energy-efficient drying process. The flexible adjustable process enables perfect drying of various foods and because of the closed air circuit, aroma, appearance and bioactivity retain in the food. By using variable and low temperatures a gentle way of drying food products, which is absolutely stress-free for the products, is guaranteed. An optimum air conditioning and air routing ensure high energy and cost savings compared to competing drying technologies. Moreover, by AIRGENEX®food the valuable condensate, which contains flavour and colour, can be collected and is available for further use. The new technology primarily addresses the food sector, which is a continuously growing market with an expect CAGR of 5.6% in the common years. Besides the food sector, another promising market is the drying market for medical plants, e.g. medical cannabis, which is expected to grow rapidly at a CAGR of 21.11%. By the innovative drying technology, Harter expects to generate additional cumulative turnover of 15 million € and an increase in staff headcount of 18 employees in 2023.

Keywords: cost saving,superfood,energy efficiency,flexibility,gentle process,healthy,organic,chamber drying,dehumidification,quality,aroma,appearance,bioactivity,closed air circuit,co2 reduction
Deciphering intrarenal communication to unvail mechanisms of chronic kidney diseases (DIE_CKD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 266345.28
EU funding (EUR): 266345.28
Participants: 2
Project status: CLOSED

Chronic kidney disease (CKD) is a major cause of morbidity and mortality, affecting over 10 % of the adult population. Regardless of the primary case, the progressed stage is characterized by scarring of all anatomical elements of the kidney - glomeruli, tubulointerstitium, and vasculature, referred to as renal fibrosis. Tubulointerstitial fibrosis has largely been viewed as a consequence of glomerular scarring, reflecting hypoxia downstream from the scarred glomeruli. Novel data suggest that an ongoing communication between the glomerular and tubular compartments (tubuloglomerular feedback) plays an important role in the progression of renal fibrosis. Particularly, injury to the tubular compartments leads to more pronounced glomerular injury in the future. DIE_CKD is designed to uncover the range and mechanisms of tubular injuries involved in the pathogenic tubuloglomerular feedback. To achieve the project objectives, double/quadruple transgenic mice with the possibility of time-dependent, subsequent injury to different compartments of the kidney will be used. This unique approach will enable a direct study of how the injury to tubular compartments predisposes glomeruli to more severe injury. Detailed analysis of the mechanisms behind these effects will be performed. The experimental data will be further confirmed in human renal biopsies of patients with Fabry disease with progressed CKD and renal fibrosis. Comprehensive histopathological assessment of long-term prognosis of sequential biopsies will be performed to analyze the involvement of individual compartments over time.

Keywords: chronic kidney disease,renal fibrosis,pai 1,fabry nephropathy