Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Language of the Arts in Italy between the Middle Ages and the Renaissance. The re-editing of documents from the Milanesi corpus and the compiling of a Dictionary of Historical-Artistic Italian (ITALART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

ITALART is a project for the creation of an Italian historical dictionary of the arts and architecture between the Middle Ages and the Renaissance. As sources for the compilation it uses documents of a practical nature produced within the context of art workshops and architectural sites: contracts, surveys, payment notes, letters, corporation statutes, technical instruction manuals, etc. It is mainly these types of documents, providing examples of everyday use of language, otherwise unobtainable, which provide valuable information on the use and spread of a technical language in Vulgar Italian during the period under consideration. An important documental contribution can be found in the two XIX anthologies on historical-artistic topics: "Documenti per la storia dell’arte senese" (Siena, Porri, 3 voll., 1854-1856) and "La scrittura di artisti italiani (secoli XIV-XVII)" (Firenze, presso l’Editore Carlo Pini, 1876), published by Gaetano Milanesi (1813-1895), a scholar from Siena. Numerous unedited materials left unused in various archives found in Tuscany and several cities in central Italy will be added to the already edited materials contained in these anthologies. These materials, however, will need to be re-edited according to modern philological criteria. The completed dictionary will be produced both in a paper and digital version, the latter published online on a dedicated website. The text corpus, digitised in its entirety and fully searchable, will also be published on the same site. Along with each transcribed text of the corpus there will be a scanned reproduction of the original document, a codicological record, and a set of philological notes, as well as brief annotations for further historical and artistic study.

Keywords: history of the italian language,italian philology,historical lexicography,italian of the arts and architecture,digital humanities
Characterizing the clinical relevance and the mechanism underlying TRIB2-mediated drug resistance to MEK inhibitiors in the context of melanoma (TRIBBLES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

Melanoma is the most aggressive form of skin cancer resistant to all standard therapies. Currently, the established treatment of metastatic melanoma includes dacarbazine (DTIC) administration associated with response rates of between 10-20% with severe side effects during treatment. Recently, the BRAF inhibitors (vemurafenib and dabrafenib) and the MEK inhibitor (trametinib) were approved for the treatment of melanoma patients with mutated BRAF (about 50% of patients) while there are several PI3K, AKT, mTOR and MEK inhibitors being tested in clinical trials. However, the effectiveness of all these treatment modalities is limited by intrinsic or acquired resistance. The host lab has discovered a novel mechanism of resistance to a broad spectrum of drugs in clinical trials/use for melanoma therapy mediated by the kinase-like protein TRIB2. This means that TRIB2 could be used as a biomarker to select melanoma patients for specific treatment options and to develop co-treatment strategies to overcome drug resistance. This project pretends to (1) understand the mechanisms underlying TRIB2-mediated resistance to MEK inhibitors and to (2) further develop TRIB2 as a prognostic and predictive biomarker for melanoma. Ultimately, the expected results will be highly relevant for the clinic as they might allow to select melanoma patients for specific treatment options and to develop co-treatment strategies to overcome TRIB2 mediate resistance.
Training experts in antigen processing to deliver new drug prototypes for cancer and autoimmune diseases (CAPSTONE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Cyprus,Greece,Greece,France,France,Czechia,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3968735.76
EU funding (EUR): 3968735.76
Participants: 11
Project status: SIGNED

Current trends in immunotherapy are to develop immuno-modulatory small molecules for intracellular targets for single therapy or combination with existing treatments. CAPSTONE scientists have recently identified the key pathway of intracellular antigen processing for modulating the immune response. ERAP enzymes that generate antigenic peptides have thus emerged as promising targets for the cancer immunotherapy and autoimmune diseases treatments. Our innovative research approach based on ERAP, targets the upstream molecular events that cause these diseases. We aim at fully understanding this pathway, deciphering the mechanisms of antigen processing dysfunctions in diseases, and developing innovative therapeutic drugs. This will provide unique opportunities for future treatment of unmet medical needs and innovative immunotherapies. CAPSTONE will thus be an excellent scientific environment to train the next generation of 15 Early Stage Researchers (ESRs) and establish an innovative cross-fertilisation between oncology and auto-immunity. Our fellows will be able to perform outstanding research at the forefront of transdisciplinary science within a high-calibre international network of academics, industries and patient associations. CAPSTONE brings together an intersectorial and multidisciplinary group of researchers in medicinal chemistry, X-Ray crystallography, cellular biology, oncology, autoimmunity, bioanalysis, mass spectrometry imaging, formulation, systems biology, personalised medicine that will expose the ESRs to key R&D stages, from basic research to pre-clinical development. CAPSTONE will prepare the ESRs for exciting career perspectives in academia, the pharmaceutical industry, biotechnology SMEs, and provide them with scientific and transferable skills and high-value professional connections. Industrial secondments and public engagement will add to a broad skill set to ensure employability in the higher ranks of academia and industry.

Keywords: antigen processing,inhibitors,small molecules,cancer,immunotherapy,innate immunity,adaptive immunity,ankylosing spondylitis,systems biology,structural biology,personalised medicine
DYNAMICS OF THE DURABLE. A History of Making Things Last in the Visual and Decorative Arts. (DURARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: SIGNED

Our cultural heritage comprises many art objects that are hundreds, some thousands of years old. How did they survive this long? While many factors determine if and how art can be preserved, one has fundamentally impacted its long-term survival: the desire to make and own artefacts that withstand the test of time. This project—DURARE—will undertake the first comprehensive study of the impact of the artisan and patron’s ambitions to craft, own and theorize durable objects on the long-term development of the visual and decorative arts. To achieve durability, artisans have worked stone and metal, created dyes and pigments thought never to fade, made surface coatings ensuring the protection of more brittle materials, and transformed soft clay into long-lasting ceramics. Patrons coveted physically stable objects; yet stability does not always ensure durability: culturally fragile gold can be melted and re-used. Beyond how the durable was made, DURARE will map the social practices influencing durability. We will also establish how, through artistic and social pursuits for durable art, humans acquired knowledge of the stability and behavior of materials over time, thus impacting knowledge traditions outside art history. Finally, we will elucidate the created practices and institutions facilitating durability, such as cultural heritage conservation and museums. Studying the history of durability in art requires hands-on experience with the materials and processes used to make and explore permanence. This project therefore uses an innovative methodology, combining historical research into art objects and textual sources with hands-on reconstructions of materials and techniques. DURARE will achieve a fundamental understanding of durability in art by charting: 1. Variations and concepts of durability in art and patronage; 2. The role of durability in the development of art and craftsmanship; 3. The impact of artistic expertise in durable materials on the history of knowledge.

Keywords: durability,craftsmanship,materials knowledge,cultural heritage,arts patronage
Twinning for an Offshore Wind Energy Partnership (TWIND)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Spain,Netherlands,United Kingdom,Portugal
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-07-01
End date: 2022-12-31
Duration (months): 42.0
Total project cost (EUR): 795825.0
EU funding (EUR): 795825.0
Participants: 4
Project status: CLOSED

The Portuguese Government has approved the Industrial Strategy for Ocean Renewable Energies (EI-ERO) with the aim of developing the country’s offshore wind potential. According to EI-ERO, offshore renewable energies have the potential to supply 25% of the electricity consumed annually in Portugal and create a new export chain in these new technologies. The government envisages that potential exports in this field could increase up to ten times the current employment in the active sectors, with the greatest potential for exports seen in the development of the floating wind technology. The overall objective of TWIND is to create a network of excellence that will dynamize a pool of specialized research professionals and trainers in the domain of offshore wind energy to support an emerging industry in Portugal in a field with a very strong anticipated growth and no dedicated existing training curriculum. WavEC will be the pivot research institution of the low performing Member State (Portugal) coordinating efforts with internationally-leading counterparts at the EU level (Spain, UK and The Netherlands) and enhancing its excellence and innovation capacity through the exchange of knowledge with these leading research organizations. The combining capabilities of partners will open the grounds to exploit existing research results and invest in developing more knowledge. These objectives will be fulfilled through a set of strategic activities well-structured throughout the project including specific training programmes on thematic topics, short-term scientific meetings, long-term staff visits, networking meetings, attendance to relevant conferences in the field, knowledge transfer workshops with stakeholders and an annual event. The networking activities and exchange of knowledge will stimulate research activities and highly qualified services that impact the economy and the society, thus benefitting not only WavEC and the partner organisations, but in general Portugal.

Keywords: offshore wind energy
Mister Maginky The new product which solves men’s incontinency problem (MM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Croatia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Mister Maginsky is a revolutionary underwear product brand that allows men more comfort and hygiene by organising and following men’s genital anatomy. Besides that it has patented the underware made for the problem of men’s urinary incontinence, by bringing a small diaper pad into the special compartment (separate space for genitals) of the underwear which would prevent urine leaking. The incontinence solution that shall be commercialized under different brand and distribution channels shares the patented underwear solution as foundation but is also separately patented together with the incontinence pads as a unique product. In November, 2016 USPTO issued a new patent for the complete incontinence product. This means the company will have exclusivity on the under-wear supporting the incontinence pad and on the pads also. This is substantial from the business model point of view as the incontinence pads are removable, expandable and used in large quantities (no need to buy the supporting underwear each time, but new pads are needed thus being more affordable to customers). The incontinence solution also has pending registration in EPO countries, Australia and Canada with first positive answers by the examiners. The product is recognized to be set as a unique business model that works on global and mass market, with the target group of men different ages.

Keywords: increasing selfconfidence,dignity of elder men
Computational and functional annotation of genomic elements during development of the model vertebrate zebrafish (ZENCODE-ITN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Spain,Belgium,Sweden,United States,Denmark,United Kingdom,United Kingdom,United Kingdom,Japan,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3724035.89
EU funding (EUR): 3724035.89
Participants: 15
Project status: CLOSED

The recent explosion of next generation sequencing (NGS) data has caught Europe unprepared and led to a critical shortage of computational biology expertise. As NGS methods are expected to become pervasive from basic science to personalised medicine there is an urgent need for highly skilled young scientists trained in both computational biology and experimental wet lab biology. Our network addresses this important problem of the postgenomic era. We aim to provide multi-disciplinary skills for a solid foundation in computational biology and developmental genomics. Developmental genomics is central to understanding of ontogeny and many genetic and congenital anomalies, but was outside the scope of the landmark ENCODE and FANTOM projects. ENCODE highlighted the need for an in vivo vertebrate model that enables high throughput in vivo functional testing of hypotheses generated from genome scale annotation. Zebrafish is an ideal model for extending the scope of genomics to vertebrate development. We aim to comprehensively annotate functional elements, decipher genomic codes of transcription, as well as coding and non-coding gene function during development and enhance zebrafish as an attractive developmental, comparative and disease model. The participants include 7 non-academic members (2 of which are beneficiaries), major zebrafish genomics laboratories, eminent computational biologists and world class genomics technology experts active in FANTOM and ENCODE. The training program involves 15 ESRs, more than 40 intersectoral and interdisciplinary secondments totalling 19 months, 7 training courses and 2 workshops/conferences. The main outcome of this programme is a cohort of researchers with computational, experimental laboratory and transferable skills ready to further their career in academia, public health and the private sector.

Keywords: zebrafish,embryology,promoter,enhancer,transgenic,cage seq,chip seq,rna seq,non coding mutation,developmental epigenomics,chromatin,non coding rna,non coding functional
Universal, mobile-centric and opportunistic communications architecture (UMOBILE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Italy,Greece,Greece,United Kingdom,United Kingdom,Portugal,Portugal
Call: Smart Networks and novel Internet Architectures (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-04-30
Duration (months): 39.0
Total project cost (EUR): 3013043.75
EU funding (EUR): 3010742.0
Participants: 11
Project status: CLOSED

Cars, sensors, home appliances, every device in the daily life of citizens is becoming a constituent in Future Internet, adding to the need to reconsider requirements and assumptions in terms of network availability and affordability to support the ever increasing traffic demand. Still, the current Internet can only evolve adequately, if its infrastructure can be devised to accommodate the emerging services. The increased cost of adding new infrastructure and capacity has a drastic effect on rural and remote communities as well as nomadic users as they become marginalized by not gaining access to crucial Internet services. Our goal is to make the Future Internet universally pervasive supporting a diverse set of services. To achieve this, we develop a universal mobile-centric and opportunistic communications architecture, which integrates the principles of Delay Tolerant Networking (DTN) and Information Centric Networking (ICN) in a common framework. We utilize the benefits of both ICN and DTN to enable resource exploitation at minimal bandwidth, opportunistic access to information and more localized access to information through novel caching strategies. UMOBILE focuses on assisting users in getting access to the content they want or content that may be of shared interest to their trust circles. By relying on an instance of the UMOBILE architecture, users are able to share information directly with other peers without relying on infrastructure or expensive connectivity services. The proposed architecture targets the mobile part of the networks, extends Internet connectivity to regions that are not typically covered enhancing network resilience and is fully backward compatible with the current Internet architecture. We will validate our architecture in a real world trial as well as participate strategically in carefully planned dissemination, standardization and exploitation activities to ensure that our architecture transcends from the lab to real world deployments.

Keywords: delay tolerant networking,information centric networking,free internet access
Physiological significance of the glucocorticoid and mineralocorticoid receptor signalling in the innate immune system (MeRGeR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Glucocorticoids, such as cortisol, play an essential role in our stress response. Cortisol signals through two receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), and it has profound effects on the immune system. To date, much of the research on cortisol action has focused on the function of GR, but almost no work has been done on the function of MR. My main aim is to unravel the role of MR in mediating the effects of cortisol on the immune response, and I would like to answer two questions: 1) How does MR activation modulate the inflammatory response? 2) How do MR and GR functionally interact to alter gene transcription? I will use an interdisciplinary approach. The first question will be answered using the zebrafish animal model, and I will determine the role of MR in wounding-induced leukocyte migration in zebrafish larvae and study the mechanism of action of MR in activated macrophages. The second question will be answered using cultured macrophages, and I will determine the occurrence of MR/GR heterodimers using biophysical approaches, and establish a functional role of the heterodimers. The outcome of this project will have a considerable impact on the current paradigm of glucocorticoid action in the immune system, and extend our understanding of the molecular actions of immune-modulating glucocorticoid drugs. My training objectives are: 1) Broadening my expertise in endocrine research using the zebrafish model system. 2) Expanding my toolbox using cell culture-based approaches and biophysics. 3) Developing complementary skills required for the management and organization of an academic research group. Furthermore, I will strengthen my scientific track record and network. The project will be performed at the Institute of Biology of Leiden University, and implementation of the project in that environment will ensure a unique position for me to run this project successfully, receive appropriate training and advance my career.

Keywords: cortisol,stress,mineralocorticoid receptor,glucocorticoid receptor,zebrafish,leukocytes
Enhancing innovation management capacities of SMEs in Montenegro (MontEENegro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Montenegro
Call: INNOVATION-02 for SGA EEN (H2020-EEN-SGA-2015-01-1, 2015)
Start date: 2015-07-01
End date: 2016-12-31
Duration (months): 18.0
Total project cost (EUR): 23419.2
EU funding (EUR): 23419.199999999997
Participants: 4
Project status: CLOSED

Enterprise Europe Network is a main support instrument for innovation in SMEs. It will provide innovation support services as well as information and advisory services such as mentoring, coaching and partner search activities for SMEs wishing to develop cross-border innovation projects. Innovation support, as a new service that EEN Montenegro will deliver, will be offered through two packages - Key Account Management (KAM) to support the innovation capacity of successful “SME instrument” applicants benefiting from Horizon 2020 specific supporting mechanism, and Services to enhance the innovation management capacity of SMEs in Montenegro in order to improve their effectiveness and efficiency, in particular aimed at those with significant innovation activities and a real potential for international growth.