Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Screening to improve Health In very Preterm infantS in Europe (SHIPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Estonia,Italy,Belgium,Poland,Sweden,France,Netherlands,United Kingdom,United Kingdom,Portugal,Denmark
Call: Evaluating existing screening and prevention programmes (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-09-01
End date: 2019-01-31
Duration (months): 41.0
Total project cost (EUR): 2993175.0
EU funding (EUR): 2993174.75
Participants: 15
Project status: CLOSED

Very preterm birth is a principal determinant of motor and cognitive impairment in later life. About 50 000 infants in the EU survive very preterm birth annually and are at much higher risk of cerebral palsy, visual and auditory deficits, impaired cognitive ability, psychiatric disorders and behavioural problems than infants born at term. However, the long term prognosis at initial discharge from hospital for each individual infant is unknown. Follow-up screening and prevention programmes aim to identify health problems early, enable interventions to improve outcome and to allow optimal management of health care. Despite the recognised importance of these programmes, little is known about their actual application and impact. These programmes consume significant resources because of the multidisciplinary staff required for clinical and developmental assessments and interventions, the coordination required to maintain contact with children after discharge and the time input from families. This project uses a unique resource – the EPICE cohort of 6675 babies born before 32 weeks of gestational age and surviving to discharge home in 18 geographically diverse regions in 2011/2012 – to assess the impact of these screening programmes on health, care and quality of life for very preterm infants and their families as well as on coverage, ability to meet needs, health equity and costs at the population-level. It will also generate new knowledge about assessment tools and methods. Four inter-related studies will be carried out in 11 EU countries by a multi-disciplinary consortium of clinicians (in obstetrics, paediatrics, and child development), researchers (in epidemiology, health services research and health economics) and a user organisation. Partners have the expertise to implement this project and the national and international renown to translate its result into better programmes and policies.

Keywords: very preterm infants,neonatal intensive care,health inequalities,childhood impairment,disabilities
Sexual Humanitarianism: understanding agency and exploitation in the global sex industry (SEXHUM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: France,United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2020-09-30
Duration (months): 48.0
Total project cost (EUR): 1600000.0
EU funding (EUR): 1341765.0
Participants: 2
Project status: CLOSED

The humanitarian fight against trafficking in the sex industry legitimizes the enforcement of increasingly restrictive migration laws and controls, which often exacerbate sex workers’ vulnerability to being trafficked. SEXHUM adopts an art-science interdisciplinary approach bringing together visual anthropology, sociology, gender and queer studies and human geography to study the relationship between migration, sex work, exploitation and trafficking. It contextualizes this relationship within the global onset of sexual humanitarianism, a concept coined by the PI. It refers to the ways migrants are increasingly represented, understood and targeted by the media, policymakers and social interventions as vulnerable to exploitation and abuse in relation to their sexual orientation or behaviour. SEXHUM adopts a migration studies perspective and a participative approach to focus on migrant sex workers addressed by sexual humanitarianism as victims of trafficking. It reappraises the concepts of exploitation, slavery and trafficking through the lens of how they are understood and experienced by migrants. The project analyses the global emergence of humanitarian migration governance by examining the impact of sexual humanitarianism across six strategic urban settings in Europe (France – Marseille and Paris), the US (New York and Los Angeles), Australia (Sydney) and New Zealand (Auckland) that are characterized by different policies on migration, sex work (criminalisation, regulation, de-criminalisation) and trafficking. The innovative method developed by the PI combines ethnographic observations, semi-structured interviewing and participative filmmaking to address the narrated as well as the affective, relational and performative dimensions of migrants’ experiences of agency and exploitation. The research will generate needed user-based data on the impact of anti-trafficking initiatives that will be highly relevant to policymaking.

Keywords: migration,prostitution,trafficking,social interventions,agency,exploitation
Multidisciplinary ADjoint-based Enablers for LArge-scale INdustrial dEsign in aeronautics (MADELEINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Italy,Greece,Sweden,France,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Maintaining industrial leadership in aeronautics (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-06-01
End date: 2021-11-30
Duration (months): 42.0
Total project cost (EUR): 5815181.25
EU funding (EUR): 5815181.25
Participants: 16
Project status: CLOSED

MADELEINE will increase the TRL and demonstrate the benefits of high-fidelity (HiFi), adjoint-based multi-disciplinary optimisation (MDO) to address the objectives of industry in terms of: - Competitiveness: by reducing time and cost of aircraft or engine development; - Environment: by finding more efficient multi-disciplinary compromises and fostering the integration of greener technologies. More specifically MADELEINE will: - Upgrade the Capability of MDO, enhanced by HiFi simulations, to capture the essential interactions between disciplines and faster identify better designs or evaluate the potential of new technologies and disruptive configurations; - Improve the Efficiency of MDO, because the efficient identification of designs, satisfying all disciplines’ constraints, requires the exploration of large design spaces; - Enhance the Usability of MDO for industrial design, through dedicated modelling, which will reduce the time to setup an MDO problem and exploit the results; - Extend the Impact of MDO on cost reduction by including requirements from manufacturing. The technologies (Multi-physics adjoint solvers, parameterisations, MDO formulations, High Performance Computing, manufacturing oriented design) will be demonstrated for airframe and engine design: aero-structure wing design, aero-acoustic fan and propeller design, manufacturing oriented aero-structure fan design and manufacturing oriented aero-thermal high-pressure turbine design. The TRL of MDO on large design spaces, with hundreds or thousands of parameters of optimisation, is expected to increase from 2-3 to 4-6. MADELEINE will last 36 months (EC requested contribution of 5 815 182€), gathering partners from 6 EU countries: 5 universities, 4 research centres, 2 software companies (including 1 SME) and 3 large industries. Their complementary expertise is essential for the realisation of the technical work, for achieving a broad dissemination and a large impact on all industries.

Keywords: adjoint based multi disciplinary optimization mdo,high fidelity hifi simulations,high performance computing hpc,multi physics adjoint solvers,manufacturing oriented design
Mechanisms of adverse effects of Beta-Agonists in Asthma (MaeBAia)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Beta2 agonists (B2as) such as the short acting salbutamol, used to relieve acute wheeze, and the long acting salmeterol used to control asthma with inhaled steroids (ICS), are almost universally used in asthma. However, there is significant concern over morbidity and mortality related to adverse effects, particularly when used without ICS, and/or in excess at exacerbation (mostly caused by rhinovirus [RV] infection). The mechanisms of adverse effects are not understood. This proposal will rock the asthma world by revealing the mechanisms of these adverse effects, thus reducing asthma morbidity and mortality. I discovered that B2as induced, and augmented RV induction (to mimic exacerbation), of the pro-inflammatory mediator IL-6 in bronchial epithelial cells (BECs) in vitro, via a cAMP dependent mechanism. ICS suppressed this induction. Hundreds of asthma-related pro-inflammatory mediators and airway mucins have potential for induction by cAMP, and for suppression by ICS. I hypothesise that adverse effects of B2as are mediated by cAMP-dependent induction of pro-inflammatory mediators/mucins in BECs and macrophages and that ICS protect against induction. I will use RNA-seq to identify all mediators induced by B2as (±RV), and suppressed by ICS, in commercially sourced human BECs and macrophages (Mφ) and in primary BECs and Mφ from 8 mild asthmatics. I will develop qPCR/protein assays for these mediators, to confirm RNA-seq data, and identify mediators to study in vivo. I will study 24 mild asthmatics at baseline, after 14 days inhaled salmeterol and after 14 days inhaled salmeterol/ICS. To mimic B2a overuse at exacerbation, I will study 10 mild asthmatics to investigate the effect of high dose salbutamol. Clinical responses will be comprehensively assessed and airway inflammation will be studied using state of the art methods. It is essential that these studies are executed urgently to inform safest use of current asthma medication, and future drug development programs
European Doctorate in Indium Phosphide PIC Fabrication Technology (EDIFY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-10-01
End date: 2022-09-30
Duration (months): 48.0
Total project cost (EUR): 1003619.52
EU funding (EUR): 1003619.52
Participants: 6
Project status: CLOSED

Photonic integration (PI) is a new standard for providing cost effective and high-performance miniaturized optical systems for a wide range of applications. However, higher adoption of photonic IC-based products and services across a wide range of verticals still calls for several optimizations namely at the level of active material for the lasers, decrease of the overall waveguide loss and development of better predictive performance methodologies implemented in the Process Design Kits (PDK). EDIFY will overcome this challenges by providing cutting-edge training to young researchers on the emerging field of integrated photonics and its translation into circuit fabrication and commercialization. EDIFY will train three ESRs at two world-leading European academic institutions and four industrial companies, thus forming a strong interdisciplinary network between industry and technical sciences to overcome specific barriers of the integrated photonics sector. Skilled in a multidisciplinary background (i.e. photonics fundamentals, circuit design and dedicated software and nanofabrication modalities) EDIFY ESRs will jointly contribute for significant improvements in the performance, power consumption and predictive methodologies of current PICs technologies with direct impact in: data communications, fibre-tothe- home, fibre sensors, gas sensing, medical diagnostics, metrology and consumer photonics. The availability of professionals combining the EDIFY ESRs skills will directly fuel emerging PIC-based innovation and ensure its exploitation by the photonic industry. Importantly, with these emerging opportunities unique career opportunities will arise for the professionals involved in this technological step change in Photonic ICs segment.

Keywords: photonic integration,photonic integrated circuits,generic photonic foundry concept,multi,project wafer,indium phosphide inp,semiconductors,process design kits
Learning to remember: the development of the neural mechanisms supporting memory processing. (DEVMEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2020-03-01
End date: 2025-12-31
Duration (months): 70.0
Total project cost (EUR): 1999520.0
EU funding (EUR): 1999520.0
Participants: 1
Project status: SIGNED

The ability to form and store memories allows organisms to learn from the past and imagine the future: it is a crucial mechanism underlying flexible and adaptive behaviour. The aim of this proposal is to identify the circuit mechanisms underlying our ability to learn and remember, by tracking the ontogenesis of memory processing. Importantly, we are not born with a fully functioning memory system: generally, adults cannot recollect any events from before their third birthday (‘infantile amnesia’). There are several accounts as to the source of this mnemonic deficit, each placing emphasis on impairments of specific processes (encoding, consolidation, retrieval). However, a general weakness in the study of memory ontogeny is the lack of neural data describing the activity of memory-related circuits during development. To directly address this knowledge gap, we propose to study the ontogeny of brain-wide hippocampus-centred memory networks in the rat. We will study to which extent memory expression relies on spatial signalling, delineate the role of sleep in memory consolidation, determine how hippocampal planning-related neuronal activity influences memory processing, understand whether the rapid forgetting observed in development is due to interference, and explore interactions between the hippocampus, pre-frontal and striatal circuits in orchestrating memory emergence. We are best placed to deliver this ambitious experimental plan due to our extensive experience of in vivo recording in developing rats which we will couple with the application of recently emerged technologies (2-photon imaging, high density electrophysiology, chemogenetic manipulation of neural activity). As our studies of the development of hippocampal spatial representations have delivered powerful insights into their adult function, we expect the work outlined here to critically advance our understanding not only of development, but also of healthy memory processing in adulthood.

Keywords: hippocampus,navigation,learning,memory,development
Herbivore-induced emissions of biogenic volatiles from arctic plants under climate warming (HIVOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-04-01
End date: 2020-08-14
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Biogenic volatile organic compounds (BVOCs) play important roles in biosphere-atmosphere interactions. However, it remains unexplored how climate warming and concomitant increase in insect herbivory interact to influence emissions of BVOCs from arctic plants. This greatly limits the current understanding of the complex abiotic and biotic processes controlling BVOC emissions in arctic ecosystems, and hampers the development of appropriate BVOC emission models. Here, I propose a project that will assess 1) how climate warming influences insect herbivory on dominant woody plants in the Arctic, 2) how insect herbivory, both alone and in conjunction with warming, influences plant BVOC emissions, and 3) how to integrate herbivory effects into the existing emission model to estimate these effects at the landscape scale. The project takes an interdisciplinary approach involving insect science, environmental science, chemical ecology and ecosystem modeling, and it combines my research experience on biotic control of BVOC emissions and the expertise that the host has on the bidirectional exchange of BVOCs between the ecosystems and the atmosphere in the Arctic. This forms a strong basis for making the project a success. The importance of biotic control of BVOC emissions in the Arctic is unknown and this project will generate pioneer results that are awaited in the scientific community. The outputs of this project will lead to important scientific breakthroughs and improve our comprehension of the factors driving BVOC emissions as well as the ecological and atmospheric functioning of BVOCs in the rapidly changing Arctic. The project will also lead to novel collaborations due to the strong complementarity between my own research and the research of the host and collaborators. The expected high-quality publications, practice training and interdisciplinary collaborations will be valuable assets that support my career development towards full independence.

Keywords: arctic,climate warming,insect herbivore,plant insect interaction,volatile organic compound
OvCa for Precision Medicine: Personalized Ovarian Cancer Treatment using High-Throughput and Microfluidic Drug Screening. (OvCaPreMed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,South Africa
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-22
End date: 2024-03-21
Duration (months): 36.0
Total project cost (EUR): 200992.32
EU funding (EUR): 200992.32
Participants: 2
Project status: CLOSED

OvCa for Precision Medicine: Personalized Ovarian Cancer Treatment using High-Throughput and Microfluidic Drug Screening. The main issue with current Ovarian Cancer (OvCa) treatments is the eventual resistance to standard platinum-based chemotherapy, which ultimately leads patients to relapse. Identifying drugs and drug combinations that overcome platinum resistance by new treatment strategies is an unmet medical need in OvCa patients that I plan to address with our technology pipeline as a Proof-of-Concept. I, Deepak Balaji Thimiri Govinda Raj, under the supervision and mentorship of Dr. Dalu Mancama (Precision Medicine) and Dr. Janine Scholefield (Synthetic Biology) at CSIR South Africa along with Prof. Nicholas Dunne and Dr. David Kinahan at Dublin City University (DCU), propose developing a cutting-edge technology pipeline with which I will identify and screen drugs and drug combinations for relapsed OvCa patients who have exhausted all other treatment options. I will use OvCa patient samples to validate the drug screening pipeline as a Proof-of-Concept. Our technology pipeline includes strategies where I will combine tissue engineering (Prof. Nicholas Dunne’s team) with microfluidic technology (Dr. David Kinahan, DCU), Chemstress platform (Dr. Jerry Clifford, ValitaCell) and my expertise in chemical biology accumulated during my PhD and three post-doctoral placements. Using this pipeline, we aim to identify drug combinations that can overcome platinum resistance and ultimately provide tailored-specific therapy options for OvCa patients. We intend our technologies to provide clinically relevant drug combinations information to oncologists.
Harnessing Hopping in Molecular-Scale Electronics: Approaching New Devices 'One Step at a Time' (HOPELEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 170419.2
EU funding (EUR): 170419.2
Participants: 2
Project status: SIGNED

With feature sizes of integrated circuits rapidly approaching molecular length scales, historical motivations to pursue the use of individual molecules in electronic circuits can no longer be justified based on their size alone. Instead, the focus has shifted towards the identification and exploitation of unusual transport phenomena unique to molecular materials (dominated by quantum mechanics) which can complement or supplant current silicon-based technologies. With the large majority of previous studies centered around the study of organic, redox-inactive molecules - typically transporting charge via single-step tunnelling processes - investigations of analogous systems that explicitly involve multi-step tunnelling, or ‘hopping’, behaviour are comparatively rare. In this project I propose to systematically study hopping processes in molecular-scale electronics (HOPELEC), with two primary objectives: (i) to construct the first single-molecule current oscillator; and (ii) probe under-explored current rectification mechanisms for single-molecule diodes. This highly interdisciplinary research area will involve the synthesis of new multi-site redox-active metal complexes capable of binding between nanoscale electrodes. Transport through these systems will be studied both at the single-molecule level using the scanning tunnelling microscope-based break junction technique, and in large area measurements using the eutectic Ga−In method. This work will expose new molecular-scale device mechanisms at the intersection of Marcus and Landauer theories, and contribute to our understanding of related processes in biology and materials science. Project results will be actively promoted through Outreach workshops on electronics/computation (translated also to YouTube). The extensive training, enhanced international profile, networks, and new experiences provided by this Fellowship will function as a 'springboard' in propelling me from Ph.D. student to independent research scholar.