Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REGional Innovation pOlicy, knowledge Spillovers, Productivity, and INstitutions (REGIO_SPIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-09-02
End date: 2015-09-01
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

The main aim of the REGIO_SPIN project is that of increasing the capacity of policy makers to design appropriate regional innovation policies in the European Union (EU). Regarding innovation policies, a paradigm shift in regional policy has occurred over the last decade in the EU, bringing innovation at the core of the regional agenda. The availability of Structural Funds, as the instrument for the EU cohesion policy, has provided regions substantial resources for innovation policy. The emphasis on the contextual nature of policy has led towards a differentiated territorial innovation policy approach or place-based policies also in EU regional policy. In fact, regional policies are still far away from being place-based: they are often similar and based on policy imitation of 'best practices’. Furthermore, their effectiveness has been questioned. Some key questions arise: Is the region the optimal scale for innovation policy? Do regions have the necessary institutional capability to manage innovation policy? Are regional institutions learning? According to which criteria policies encouraging University-Industry linkages should be designed? These are questions which go at the hearth of the place-based approach of the EU cohesion policy. The REGIO_SPIN project proposal aims to respond to these questions on the ground of empirical evidence. It will take an interdisciplinary perspective bringing together policy-oriented research with the geography of innovation and system of innovation, and the role of institutions. The empirical analysis, covering the European regions in several countries, is divided into three objectives: i. To explore the relationship between quality of the institutions and innovation policy impact; ii. To explore the extent to which policy leads to institution building; and iii. To explore the connection between different the nature of University-Industry linkages and types of Regional Innovation Systems.

Keywords: innovation policy,regional innovation,clustering,institutions,knowledge spillovers,university-industry linkages
Active Gurney Flap (AGF)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Portugal
Call:  (SP1-JTI-CS-2011-02, 2011)
Start date: 2012-05-01
End date: 2015-04-30
Duration (months): 36.0
Total project cost (EUR): 299577.0
EU funding (EUR): 202422.5
Participants: 1
Project status: CLOSED

A huge effort has been dedicated to improving the performance of aircraft propellers, as well as of aerodynamics surfaces, having in mind the maximization of the overall efficiency and reduction of the fuel consumption. In that sense, blade morphing technologies have become a must for long term developments. In meanwhile, however, the effects of several smaller changes have been investigated with very good preliminary results, such as, Gurney flaps and other trailing edges. In this project, Active Space Technologies (AST) proposes to develop a new concept of an Active Gurney Flap (AGF) in collaboration with the Green Rotorcraft Consortium (GRC1). The project scope is the complete design and manufacturing of the controller, actuator and Gurney flap mechanism, which will be assembled in a set of four scaled model helicopter blade and tested in a wind tunnel. The AGF system must be compliant with a set of challenging system requirements related with the actuation frequency (60Hz), the required maximum deployed extension (3% of the blade chord), the limited available room at the flap location (about 1.5 mm) and the Gurney flap movement perpendicular to the blade surface.

Keywords: gurney flap,helicopter,mecatronic,miniaturization,increase lift force,reduce fuel consumption
Extracellular adenosine role in energetic metabolism during immune response (IMMUNE ENERGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-09-27
End date: 2015-03-26
Duration (months): 30.0
Total project cost (EUR): 283229.75
EU funding (EUR): 283229.75
Participants: 1
Project status: CLOSED

Immune response is energetically demanding process and although an improper regulation of energetic metabolism during immune challenges leads to various complications in human patients it is largely unknown how is the energetic metabolism regulated during the immune response. Extracellular adenosine is a strong candidate for this type of regulation; nevertheless it has never been studied for such role. Our work using Drosophila as a model strongly supports the view of adenosine being the signal connecting energy reallocation with immune response. The regulation of extracellular-adenosine levels and its signaling are now well defined in flies and the model allows various manipulations with the adenosine system in vivo. Therefore the model is now perfectly suitable for a systematic analysis of the adenosine regulation of energetic metabolism during various infections which should lead to a better understanding of the energetic costs of mounting an immune response. Results of such analysis could greatly contribute to our knowledge of host-pathogen interactions and some highly important biomedical problems. Goal of this project is for the applicant to learn the complex methodology of Drosophila infections and use these obtained skills for the systematic analysis of the adenosine role during immune response.

Keywords: immunology,bioenergetics,functional biology,molecular genetics
Advanced Pylon Noise Reduction Design and Characterization through flight worthy PIV (ACCTIOM)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: France
Call:  (SP1-JTI-CS-2011-02, 2011)
Start date: 2012-02-01
End date: 2016-06-30
Duration (months): 53.0
Total project cost (EUR): 570160.0
EU funding (EUR): 390860.0
Participants: 2
Project status: CLOSED

It is proposed in this research programme to optimize the pylon shape of a Counter Rotating Open Rotor (CROR) propeller and its embedded flow control system, in order to reduce the noise emission through pylon wake attenuation, by means of advanced experimental methodology, such as 3CHD-PIV, adapted to in-flight tests. It is proposed to decompose the project into subtasks of increasing complexity. Each task falls within the scope of either ISAE or AAE. Thus, ISAE and AAE offer to join their different skills to elaborate a work-plan based on well-defined responsibilities. The subtasks are summarized below: 1.Optimization of the flow control device for the 2D pylon. 2.Detailed design and manufacturing of the 2D type pylon wind tunnel model and its instrumentation. 3.Low speed wind tunnel tests of the 2D pylon without open rotor, in a non vibrating environment, including parametric studies on the advanced flow control devices parameters and boundary layer transition effects. 4.Comparison between experimental results and numerical prediction. Analysis of the results, physical understanding and recommendation for further improvement of the concept. 5.Definition of vibration environment simulators (VES), in compliance with Airbus inputs from in flight tests. 6.Detailed definition and manufacturing of VES applicable to the different PIV subsystems (cameras, laser, laser sheet generation devices) as implemented in the wind tunnel. 7.Characterization of the limits of the vibration spectrum supported by the PIV subsystems, beyond which vibration-induced errors on PIV measurements impose corrections on raw data or on PIV subsystems attitude. 8.Definition of correction methodology to correct PIV measurements, through raw data manipulation or PIV subsystems vibration attenuation, in order to recover a non disturbed PIV measurement. 9.Validation of the correctiion methodology in wind tunnel by replicating subtask 3.

Keywords: flow control,shape design optimization,pylon wake,noise reduction,in-flight measurements,particle image velocimetry,vibration-induced errors correction methodology
Design and Synthesis of Novel Bilayered Scaffolds for Periodontal Tissue Regeneration (BIODENTISSUE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-06-16
End date: 2014-06-15
Duration (months): 24.0
Total project cost (EUR): 167390.4
EU funding (EUR): 167390.4
Participants: 1
Project status: CLOSED

Current data concerning the use of scaffolds in Periodontal Tissue Regeneration are far from sufficient for successful tissue-engineering therapeutics in the periodontology field. Consequently, we have identified the need for the development of advanced biomimetic scaffold materials, which are versatile enough to be targeted for tooth-specific applications and capable to drive the growth and functional differentiation of stem/progenitor dental cells into matured organized periodontal tissues in a controlled manner. The aim of this project is the design, synthesis and optimization of an advanced bilayered composite scaffold based on glass-ceramic foams combined with electrospun collagen-based meshes that mimics the complex structure of periodontium, i.e. the hierarchical structure of cementum and alveolar bone, the periodontal ligament and the continuous, fibrous interface between these tissues. The implementation of this project is designed through the integration of three objectives, which involve: i) the synthesis and optimization of glass-ceramic scaffolds for cementum/alveolar bone regeneration, ii) the development and characterization of tailored collagen-based fibrous scaffolds for periodontal ligament regeneration, and iii) their innovative combination for the construction of novel bilayered scaffolds to regenerate the complex tissue interface at the periodontium.

Keywords: materials engineering,biomedical engineering
Application of Lithiated Carbamates to the Asymmetric Synthesis of Sulfolipid-I (ALCLASS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Mycobacterium tuberculosis, the causative agent of human tuberculosis, is unique among bacterial pathogens. Sulfolipid-I (SL-I) is the major constituent metabolite of thick cell wall present in Mycobacterium Tuberculosis (M-TB). SL-I comprises of a disaccharide and four chiral hydrophobic lipid substituents, the overall structure of which is responsible for the resistance of M. Tuberculosis to antibiotics. While SL-I has been shown to elicit specific responses from immune cells, the mechanistic basis of these effects, biosynthesis and biological activities are unknown. Although a number of studies have been reported on the synthesis of disaccharide core and hydrophobic lipids of SL-I, major challenges reside in the synthesis of chiral hydrophobic lipids, which comprise multiple stereocenters. It is aimed to synthesis the enantiopure sulfolipid-I in a short synthesis by utilizing the recent methodology developed by the Aggarwal group involving the reactions of chiral lithiated carbamates with boronic esters. This new strategy is a potentially powerful tool for the iterative asymmetric synthesis of complex molecules in short order.

Keywords: sulfolipid,carbamate,borane,homologation
Substrate-induced phases of discotic liquid crystals (DISCO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-05-01
End date: 2014-04-30
Duration (months): 24.0
Total project cost (EUR): 177000.0
EU funding (EUR): 177000.0
Participants: 1
Project status: CLOSED

The structure of ordinary liquids is altered near a solid surface. The symmetry breaking leads to positional and orientational ordering of molecules. The ordering effect extends generally up to a few molecular dimensions only. A solid interface also plays a well-documented role on the nucleation and growth of crystals. But probably the richer physical situations are observed in the case of liquid crystals, notably anchoring and orientational wetting effects. Liquid crystals are ideal systems to study surface effects for many reasons. First, their fluid character allows reaching thermodynamic equilibrium easily. Second, surface-induced orientational and positional ordering effects can be selectively studied. Third, liquid crystals display several phase transitions around which peculiar phenomena occur. Fourth, liquid crystalline phases are highly symmetrical and allow an easy structural characterization by powder X-ray diffraction. Fifth, liquid crystalline compounds are generally more soluble and easier to process into thin films than crystals. In case of discotic liquid crystals, unusual and interesting phases appear in the vicinity of solid substrates. Such “thin film” phase differs from those for crystalline compounds, where surface induced polymorphism occurs. Such thin film phases in crystals are thermodynamically unstable since a perturbation of the system leads to its transformation into a more stable polymorph that exists also in bulk. The substrate-induced phases observed in discotic liquid crystals are more ordered than the bulk ones and exhibit a three-dimensional order whereas the bulk ones are liquid crystalline and have a two-dimensional order. This project aims to gain a fundamental understanding of the physical and chemical parameters that governs the formation of substrate-induced phases in discotic liquid crystals through a combined theoretical and experimental approach.

Keywords: surface chemistry,chemical physics,soft matter and polymer physics
Two-Step-Strategy towards an Orthogonal Bio-System (MAZPROTEC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-03-01
End date: 2014-02-28
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

The integration of orthogonality is a crucial research strategy in the rational design of biological systems for novel applications. In order to produce such highly predictable orthogonal systems, we propose to employ cell-free systems of highly engineered composition generated from living cells, which are complex enough to reproduce the major synthetic capabilities of living cells - such as the synthesis of natural and artificial saccharides - but are simplified enough to come close to truly engineerable systems. We propose a two-step-strategy: In a first step, the protein synthesis of a growing bacterial cell will be channeled solely to a limited set of system components with the help of the RNA-interferase MazF. In a second step, the cells will be homogenized and the resulting cell-free extract, already enriched in the required protein components, will be subjected to selective hydrolysis of predefined proteins, which otherwise would connect the designed system to the remaining protein background, which would make the performance of the complex system unpredictable. As a proof-of-concept, we propose to implement a preparative 12-step synthesis from cheap glucose and N-acetyl-glucosamine to a valuable antiviral-precursor, N-acetyl-neuraminic acid.

Keywords: health sciences,natural sciences,technological sciences
A NOVEL TRI-GENERATION SYSTEM POWERED BY SOLAR ENERGY (ANTSPSE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-11-01
End date: 2014-10-31
Duration (months): 24.0
Total project cost (EUR): 270145.8
EU funding (EUR): 270145.8
Participants: 1
Project status: CLOSED

This International Incoming Fellowship will bring a leading Chinese researcher to work in the Europe. The project has been carefully chosen to match Dr Huang's expertise in heat and mass transfer and solar energy systems with the expertise in renewable energy application in power supply and HVAC technologies at the University of Nottingham so as to maximise the benefit to the Europe. The project aims to develop a tri-generation technology that can be used to provide decentralized electricity, heating and cooling powered by solar energy. The tri-generation is achieved by integration of steam engine with desiccant cooling/heating technology. The desiccant cooling/heating system will use an innovative membrane technology to maximise heat and mass transfer between the air and the desiccant solution and also eliminate the carryover issue associated with liquid desiccant systems. The proposed research investigates electricity output, heat and mass transfer properties through theoretical and experimental measures. A small scale prototype system will be designed and constructed and tested under a range of conditions. The proposed programme of work will take a maximum of 24 months to complete. The training of the researcher will be achieved through regular supervision and mentoring and a carefully managed research programme including computer modelling of heat and mass transfer, development of a prototype system and primary test as well as economic and environmental analyses.

Keywords: thermal engineering,hybrid energy systems,solar thermal technology,trigeneration,self-cleaning
Paleomagnetism of extraterrestrial materials: a clue to early magnetic fields in the solar system and asteroids differentiation (EXTRAMAG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-08-01
End date: 2014-08-31
Duration (months): 25.0
Total project cost (EUR): 164684.98
EU funding (EUR): 164684.98
Participants: 1
Project status: CLOSED

The study of the remanent magnetization (paleomagnetism) of extraterrestrial materials gives clues as to the history of the primitive solar system and its evolution. Indeed, paleomagnetic studies of meteorites provide a unique window into understanding early solar magnetic fields generated externally from planetesimal bodies (by the young sun during its putative T Tauri phase, or within the protoplanetary nebula), as well as magnetic fields generated within the planetesimals through convection of a molten core (dynamo field). After nearly two decades of relatively dormant activity, the field of extraterrestrial magnetism has recently reactivated, but many questions remain unanswered: Did the Sun pass through a T Tauri phase? How common were differentiated planetesimals with a convective core in the Early solar system? What was the timing of the differentiation of these planetesimals? Did the Moon, or Vesta have a core dynamo? What was the timing of these dynamos? The aim of this project is to participate to the current effort in answering those questions. More precisely we will focus on: 1) primordial fields in the solar nebula; 2) differentiation processes in asteroids; 3) Lunar magnetism We will address these questions through detailed paleomagnetic studies of selected samples, using good practices that have up to now only seldom been applied to meteorites (like the determination of the nature of the natural remanence, with tests for shock and viscous remanence), advanced instrumentation (like small-scale magnetic mapping), and the interpretative framework provided by the recent progresses in the field of meteoritics (in particular thermochronology). Studied samples, that are already in our hands, will be carbonaceous (CV, CK, CM, CO, CI), enstatite and Rumuruti chondrites, aubrites, basaltic eucrites, and Apollo lunar rocks. They have all been carefully selected on the basis of their age and petrography, to provide answers to the above-mentioned questions.

Keywords: paleomagnetism,meteorites,lunar samples,differentiation and dynamos,magnetic fields in solar nebula