Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Maximising the bioactive potential of flowers for applications in nutritional hybrid products (FlowerPower)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 1
Project status: SIGNED

There is an urgent necessity to develop new nutritional products with enhanced functionality to meet the global need for healthy and sustainable foods. Although edible flowers are sustainable rich sources of vitamins, minerals and antioxidant compounds, they have been underutilized in human nutrition and remain underexplored by the food industry. FlowerPower will go beyond the state-of-the-art by unlocking the nutritional and techno-functional potential of edible flowers naturally found in Ireland and other European countries. To this end, this project aims to develop hybrid dairy products fortified with carotenoid-rich flowers. Plant proteins will be used as delivery systems to improve carotenoid stability and enhance the technological and digestive functionality of the product. Additionally, combining animal and plant ingredients in hybrid foods contributes to bridge the gap between nutritional needs and sustainability, supporting plant-based dietary choices while addressing new rising market demands, e.g. flexitarian consumers. The multidisciplinary research programme is comprised of four parts. (1) Characterization of the composition of petals from 2 flowers and structural and technological properties of 4 plant proteins (WP1). (2) Characterization of carotenoid-protein interactions in 2 flower/plant-protein combinations and assessment of their impact on carotenoid stability (WP2). (3) In vitro digestion of hybrid dairy foods in 2 model food structures with selected flower/plant protein combinations to assess carotenoid bioaccessibility (WP3). (4) Selection of hybrid dairy foods with enhanced technological and/or digestive features to develop prototypes for instrumental analysis and sensory evaluation (WP5). This project addresses Pathway 4 - EU's FOOD 2030 aimed at encouraging a dietary shift towards plant-based diets. Knowledge and concepts from this work are expected to increase competitiveness of the dairy sector by creating opportunities for new markets.

Keywords: alternative proteins in vitro digestion carotenoids
Full qualification in France of large-scale HYdrogen underground storage and replication from Germany to all European countries (FrHyGe)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: France,Germany,Spain,Belgium
Call: Large-scale demonstration of underground hydrogen storage (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 27240481.25
EU funding (EUR): 19994886.4
Participants: 19
Project status: SIGNED

If the solution for integration of intermittent renewable sources to decarbonate the industry and mobility is hydrogen, for example with European Hydrogen Backbone initiative, large-scale storage of H2 technical feasibility and economic viability is still hampering wide EU market uptake. FrHyGe main goal is to demonstrate and qualify in industrial environment in France the injection and withdrawal of H2 in a current natural gas commercial storage site. But FrHyGe will also deliver the conversion process and up-scale strategies to foster EU replication of H2 storage in caverns, starting with an ongoing project in Germany to accelerate know-how transfer and economic viability. FrHyGe objectives are: • To develop and implement two conversion processes from natural gas or brine cavern to hydrogen storage • To demonstrate H2 storage and cyclability in a 3000 tons potential cavern with 100 cycles from 1h to 1 week • To study the local hydrogen value chain and the techno-economic impacts on local actors and to upscale and deploy H2 storage along European Hydrogen Backbone • To assess the risks and environmental impacts of H2 cyclic storage in salt caverns and provide guidelines for safety, regulation and normative adaptations in Europe FrHyGe will open a path towards a potential of commercial 38 ktons of H2 storage in several EU countries as soon as 2030, and up to 1.5 Mtons in 2050 through conversion and creation of caverns, leading to a CAPEX below 10 €/Kg of H2 stored. To succeed, FrHyGe gathers EU leading H2 industries and research centres, led by worldwide underground storage actor Storengy, willing to make happen large-scale and multi-site H2 storage in caverns.

Keywords: h2 underground storage,cavern to h2 storage conversion process,hourly cyclability
Targeting Amino acid uptake into NK cells to limit pathogenesis in sepsis (TANK_Sepsis)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

Sepsis is a global health challenge, accounting for around 20% of deaths worldwide. While sepsis is induced by uncontrolled dissemination of infection, significant contribution to disease pathogenesis is made by overwhelming production of proinflammatory mediators, a so-called “cytokine storm”. There is a pressing need for new target therapies to dampen this immunopathogenesis while still allowing bacterial clearance. Although Natural Killer (NK) cells are vital for host innate responses, they are important contributors to the tissue damage during bacterial sepsis, in particular, via production of excessive amounts of IFNg. Therefore, dampening NK cell IFNg production represents a promising tool for sepsis treatment. Recent studies from the host institution have shown that metabolic processes are essential for NK cell functions. In particular, certain amino acid transporters are key to support IFNg expression by NK cells. I thus hypothesize that limiting amino acid supply to NK cells will restrict production of IFNg, dampen the cytokine storm, and improve the course of bacterial sepsis. To prove this idea, I will combine my experience in mouse models of septic shock with host institution’s background on immunometabolism and bacterial infections. First, I will employ a powerful “metabolic toolbox” established at the supervisor’s lab to characterize metabolic phenotype of NK cells in bacterial sepsis. Next, I will use mice with genetic ablation of key amino acid transporters specifically in NK cells to study their role in “cytokine storm” during sepsis. Finally, I will test pharmacological compounds, able to limit amino acid availability, for their potential to prevent excessive inflammation during sepsis. At the end of the project, I will acquire key professional skills, including “metabolic toolbox” and bacterial infection model, that will benefit my further career, as well as characterize new potential therapeutic opportunity for treatment of sepsis.

Keywords: immunometabolism nk cells sepsis
Sharing and caring of informal and non-formal learning environments (xFORMAL IRIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Italy
Call: HORIZON-MSCA-SNLS-2021-IBA (HORIZON-MSCA-2021-SNLS-IBA, 2021)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 10625.0
EU funding (EUR): 10625.0
Participants: 1
Project status: SIGNED

The Marie Skłodowska-Curie actions pay particular attention to physical accessibility and inclusion and foresee financial support for the additional costs entailed by recruited or seconded researchers with disabilities.

Keywords: epub3 digital skills soft skills inclusive research community storytelling
Exotic phases in Raman-coupled quantum gases (Epiquant)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

The physical properties of materials are determined by the interactions of their constituents and the emerging band structure. Ultracold atoms have emerged as a powerful tool to simulate these quantum many-body processes in a highly controlled environment. In this project, I will explore exotic phases in bosonic mixtures of ultracold potassium by engineering the interplay of single-particle dispersion relation and interactions via Raman dressing. My research will focus on two distinct scenarios: the continuum and discretized chains. In the continuum case I will focus on the celebrated supersolid stripe phase, which simultaneously displays superfluidity and a spontaneous breaking of translational symmetry. I will characterize the collective crystal modes of the phase, a smoking gun for supersolidity, as well as realize a novel quantum liquid with supersolid characteristics. In the discretized case, I will explore the effects of strong interactions in artificial gauge fields by realizing semi-synthetic flux ladders, a minimal instance of the Hofstadter model. This model is famous for capturing the fractional quantum Hall effect, but displays a myriad of strongly interacting, yet experimentally scarcely explored phases. The project will demonstrate the vast potential of Raman-coupled systems by deepening our understanding of supersolids and providing new insights into strongly correlated systems in the presence of artificial gauge fields. By using a common mechanism that gives rise to both supersolidity and artificial magnetic flux, the project will, at large, reveal connections between these two important topics.

Keywords: ultracold potassium,spin orbit coupling,supersolidity,raman dressing,artificial gauge fields
Astral Automation: A Modular and Scalable Lab Automation Platform for Drug Discovery (AAS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 18.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Astral Automation is developing a modular and scalable lab automation platform to accelerate early-stage drug discovery. The project aims to remove the key bottlenecks in the physical experimentation required as part of the drug development cycle by integrating robotics, software, and Digital Twin (DT) technology into a single, intelligent system. Our objective is to enable fully automated, 24/7 research laboratories that can plan, simulate, and optimise workflows before physical deployment. Through the use of DT technology, laboratories will be able to design and validate their layouts and processes virtually, reducing capital risk, operational inefficiency, and environmental waste. The modular design allows flexible scaling and easy integration with existing laboratory infrastructure, supporting a faster, more cost-effective transition to automated research environments. Astral will achieve these goals by advancing its proven TRL6 prototype to a commercially deployable platform (TRL8–9). Funding will be used towards establishing development facilities, hiring key personnel and building out the product portfolio. This will allow us to accelerate commercialisation and early customer deployments. The project aligns with the objectives of the Horizon Europe Work Programme by promoting industrial innovation, digital transformation, and sustainability in the European life sciences sector. It will help accelerate access to new medicines, strengthen Europe’s technological leadership in automation and AI-driven research, and create high-value jobs in engineering and biotechnology.

Keywords: lab automation,ai drug discovery,robotics and software,digital twin,scheduling and orchestration
EPIGENETIC MEMORY BY COMMUNICATION ACROSS CHROMOSOME SCALES (EPICHS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

The ability of cells to specialize and maintain their identity through multiple cell divisions is critical for development, tissue renewal and diseases avoidance. A key frontier is therefore to understand how genome organization and function is inherited to daughter cells. EPICHS targets a new paradigm for how epigenetic information is propagated, in which communication between the 2D epigenome and 3D genome organization maintains cellular identity. Inheritance of epigenetic states involves the copying of modifications on DNA and histones in cis on replicated DNA. However, this model lacks a spatial dimension, integrating that similar chromatin types separate spatially in the nucleus and replicates in a coordinated fashion. DNA replication severely disrupts the 2D epigenome, but it is unknown how replication locally impact on 3D organization and how spatial context shapes replication of the epigenome. EPICHS will interrogate chromosome replication across scales; we will develop new technology to address the interplay between 2D and 3D epigenome in epigenetic inheritance across replication. We will combine these technologies with machine learning, proteomics and fast-acting degrons to manipulate chromatin replication. Functionally, we will explore replication-induced 2D/3D dynamics and inheritance mechanisms in regulation of transcription and stem cell plasticity. Together, this will 1) provide the first knowledge of interdependencies and directionality in propagation of 2D and 3D organization, 2) reveal functions of DNA replication-induced plasticity in cell fate transitions, and 3) unveil spatio-temporal epigenetic mechanisms and their synergy with cis-based memory in maintaining cell identity.

Keywords: chromatin replication,3d genome organization,cell fate decisions,proteomics,transcriptional regulation
Agents of Logistics and Infrastructure in Eighteenth Century Alpine Transit Traffic (ALPINNKONNECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2499921.0
EU funding (EUR): 2499921.0
Participants: 1
Project status: SIGNED

ALPINNKONNECT centres on operating trans-European commercial traffic as engine and manifestation of eighteenth-century prosperity. The project focuses on the interplay of agents, material prerequisites and natural impacts along main Alpine transit routes, applying an approach of socio-material-natural interconnectedness. It advances the hypothesis that transportation required a broad participation to cope with the enormous efforts and provided an important source of income. Hence, seen through the lens of transit traffic, new light will be shed on local social fabrics. Among the key figures, ALPine INNKeepers acted as cONNECTing agents and inns operated as multipurpose hubs of transit traffic. Considering the fundamental importance of transit traffic, the fragmented and dated state of research is striking. ALPINNKONNECT breaks new ground by adopting approaches of New Materialism and a relational concept of logistics and infrastructure, focusing on innkeepers, hauliers, carters, raftsmen, muleteers and rod cooperatives as protagonists and integrating households, marriage, kinship, property and gender as factors in this economic key sector. The main goal is to arrive at a comprehensive and empirically verified understanding of the preconditions, processes, implications and dynamics of transit traffic and its changes. ALPINKONNECT argues that transit routes remained vital during the eighteenth century, not despite, but complementary to, the economic rise of north-western Europe and its maritime traffic. The principal research question is: how did the interplay between the different agents, the built materiality and Alpine nature work? How did the flows of goods, which accounted for a significant share of the early modern European economy, cross the continent on Alpine routes? How was their transit maintained, facilitated or hindered? ALPINNKONNECT proposes to reconceptualise social history by symmetrically linking historical anthropology with New Materialisms.

Keywords: socio material natural interconnectedness,historical anthropology,new materialisms,operating transportation,local participation,maintenance,administration,innkeepers,hauliers,cooperatives
Nano- and colloidal plastics in soil: input, plant uptake and risk assessment (NanoSoil)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1420836.0
EU funding (EUR): 1420836.0
Participants: 1
Project status: SIGNED

Plastic pollution has been identified as a key to soil health. Yet, information on inputs and concentrations in agricultural soil is limited to microplastics (> 1 µm-5 mm) or larger particles, but nothing is known about submicron plastics, including colloidal plastics (CPs; 1-1000 nm) and nanoplastics (NPs; 1-100 nm), due to a lack of analytical methods. This is critical because mainly submicron plastics harm soil biota, are taken up by plants, and thus pose a risk to human health via the food chain. As plastic pollution is rising, we urgently need to quantify submicron plastics in agricultural soils and the resulting plant uptake and contamination of our food to safeguard our food production. Hence, the NanoSoil project is designed to test the following hypotheses: i) submicron plastics can be routinely detected using Field Flow Fractionation (FFF) with adaptions from environmental colloid tracing, ii) agricultural practices (compost and sludge application, wastewater irrigation, plastic mulching) are main pathways for submicron plastics into soil, as well as iii) the use of so-called biodegradable foils in agriculture. I further hypothesize that iv) uptake and accumulation of CPs and NPs in crops are polymer- and plant-specific, temperature- and humidity-dependent, with mainly NPs reaching edible parts. To quantify submicron plastics, I will i) optimize a recently developed method using FFF and pyrolysis gas chromatography. This method will then ii+iii) be used on soil samples from agricultural fields with known plastic input pathways for conventional and biodegradable plastics, including an Europe-wide survey and existing controlled field trials. Finally, iv) plant uptake will be assessed for representative crops. With my combined expertise in nanoparticle and plastic analysis in soil, NanoSoil will for the first time generate data that will form the basis for all future environmental fate and ecotoxicology studies of plastics and a robust risk assessment.

Keywords: microplastic,environmental pollution,soil pollution
Exponential Motives and Arithmetic Gevrey Series (EMOTIVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1605475.0
EU funding (EUR): 1605475.0
Participants: 2
Project status: SIGNED

Exponential motives are a powerful tool for the study of a host of objects attached to an algebraic variety along with a regular function, ranging from exponential sums over finite fields in analytic number theory to Landau-Ginzburg models in mirror symmetry. This project revolves around applications of the abstract theory of exponential motives to concrete problems pertaining to arithmetic Gevrey series, after my recent breakthrough in solving a 1929 question by Siegel. Arithmetic Gevrey series are power series with algebraic coefficients that satisfy a differential equation and certain growth conditions of arithmetic nature. Depending on the specific shape of these conditions, they come into three main flavours: G-functions, E-functions, and Э-functions. We plan to make significant progress on three interrelated questions about arithmetic Gevrey series: What are the transcendence properties of their special values? What is the nature of the differential equations they satisfy? Do they admit integral representations coming from geometry? The most important examples of G-functions arise from period functions of one-parameter families of algebraic varieties. A geometric interpretation of E-functions and their differential equations was lacking until exponential motives entered the scene. We will systematically exploit the new possibilities they offer to make the differential Galois group act on special values of E-functions, elucidate the local-to-global nature of index theorems for E-operators, prove general structure results for Hodge loci of exponential motives, and reconcile the Siegel-Shidlovsky theorem with Wüstholz’s analytic subgroup theorem, with a view to separating special values of E-functions and G-functions. We will also advance our understanding of the relation between G-functions and hypergeometric series, as well as the arithmetic of regularised special values of Э-functions.

Keywords: periods,motives,kontsevich zagier conjecture,motivic galois group,g functions,e functions,transcendence of special values,hypergeometric functions