Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Osmotic Wearable Bolus Injector (oWBI) for viscous drug delivery (oWBI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Denmark
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-04-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With more drugs coming onto the market as combination products, i.e. drug products paired with delivery devices pharmaceutical companies are paying closer attention to integrated delivery systems. Due to: 1) the trend in the change in drug formulations, in order to migrate from intravenous to a more cost-effective and convenient subcutaneous (SC) drug administration; and 2) the trend in moving from synthetic derived drugs to biologically drugs that are more complex and have higher viscosity and therefore require delivery of larger doses; resulted in the need for a new class of injection devices - wearable bolus-injectors (WBIs). WBIs are prefilled, disposable devices that are worn on the body of a patient during the SC self-administration of a large dose of medication. The WBI market is estimated to grow in CAGR of 170% between 2015 – 2020 and achieve €6.9Bn by 2025, and pharmaceutical companies are actively seeking for reliable and cost-effective WBIs, providing optimal injection performance at an attractive unit cost and low cost of customization. Subcuject ApS (SCJ) is a medical device company set to commercialize a new class of WBIs - Subcuject - that makes use of the simple, predictable and strong force of nature: osmotic pressure. Unlike the current WBIs, Subcuject is fully mechanical, bearing no electronic components, resulting in a more flexible, reliable and eco-friendly device at a remarkably lower cost than competitor’s (75 - 86% cost reduction). SCJ business strategy is based on establishing multiple licensing deals (depending on the drug type, disease, region) with pharmaceutical companies. The Subcuject device is expected to significantly enhance SCJ’s profitability, with an expected accumulated profit of €97M, 5 years after project completion. Moreover, the successful achievement of the project objectives will assist SCJ to be a leading company in the WBI device segment in a market today dominated by U.S. companies.

Keywords: medical device,wearable bolus injector,cost effective,disruptive,subcutaneous drug delivery device,self administration
Personalised Medicine for Intervertebral Disc Regeneration- Integrating Profiling, Predictive Modelling and Gene Activated Biomaterials (INTEGRATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1999543.0
EU funding (EUR): 1754543.0
Participants: 2
Project status: SIGNED

Lower back pain is a global epidemiological and socioeconomic problem. Biomaterial and cell-based therapies have been pursued for the treatment of degenerated intervertebral disc (IVD), with a number of clinical trials underway. However, the degenerated intervertebral disc has a distinct environment (e.g. altered oxygen, glucose, acidity, inflammatory cytokine levels) that is unique to an individual (i.e. patient-specific) and will ultimately determine the likelihood and rate at which regeneration can occur. A “one size fits all” approach will lead to the failure to demonstrate efficacy of advanced therapies, as they are not being designed or personalised for individual patients. This proposal envisions a future whereby advanced gene activated cell therapies are personalised (targeting regeneration or modulating inflammation) to treat back pain based on knowing the individuals unique disc microenvironment. This will be achieved through profiling of individual patient disc microenvironmental factors, with in vitro screening and in silico modelling to design cell therapies and predict regeneration outcomes (Aim 1) combined with the development of tailored functionalised gene activated biomaterials (Aim 2), to enhance matrix formation and modulate the inflammatory processes (Aim 3). Gene-based therapy offers several advantages over direct delivery of proteins or small molecules, among them the possibility of sustained efficacy and endogenous synthesis of growth factors or suppression of inflammatory factors and pathways. The platform technology (personalised gene activated biomaterials to regulate regeneration and inflammation) and knowledge (tailoring cell therapies to suit patient-specific microenvironments) generated through this research are beyond the current state-of-the-art and will provide a significant transformative scientific and clinical step change opening new horizons in minimally-invasive therapeutic strategies.

Keywords: injectable hydrogels,tissue regeneration,spine,stem cells
Characterisation of permissive and non-permissive phagosome environments during Salmonella systemic infection (SalPhagoHet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Infectious diseases represent a major threat to global human health today. Antibiotic misuse has induced rapid emergence of resistant bacteria and it is becoming increasingly challenging to identify new, efficient drugs. Novel control strategies are urgently required. This project intends to uncover key host immune factors determining the outcome of a bacterial infection with the aim to identify strategies to synergise with the immune system. Emerging evidence suggests that heterogeneous host-pathogen encounters play a key role in disease outcome. To investigate the role of distinct tissue microenvironments during infection, I will use Salmonella enterica to study the immune properties of neutrophils and resident tissue macrophages, previously shown to be non-permissive and permissive environments, respectively. Specifically, I will use a novel approach of phagosome isolation by fluorescence-activated cell sorting and will combine it with sensitive high-resolution mass spectrometry. With this state-of-the-art technology, I will identify key host factors required for phagosome formation by proteomics, which will provide relevant insights into the biology of two key professional phagocytes with important applications in infection biology and immunology. Secondly, I will analyse Salmonella responses to these host determinants using proteomics and stress-inducible promoter fusions to reporter genes. This will highlight key bacterial strategies for intracellular survival and thus novel antimicrobial targets. Finally, I will confirm the in vivo role of identified key factors using a murine infection model. This integrated approach, investigating the host and the pathogen, will be broadly applicable to study other important infectious diseases. This project will highlight specific host and pathogen responses with the aim to close permissive niches where suboptimal antimicrobial exposure allows pathogens to survive and spread.

Keywords: salmonella,infection,heterogeneity
Numerical Restoration of Historical Musical Instruments (NEMUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy,United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1497265.0
EU funding (EUR): 1497265.0
Participants: 2
Project status: SIGNED

The conservation, restoration and maintenance of rare and precious musical instruments is currently problematic, and will become increasingly so in the future: most instruments in museum collections are already out of playing condition, and deteriorating to the extent that their unique sounds will eventually be lost. Curators are well aware of the ethical problems associated with restoration and maintenance, and digital technology offers a solution to the problem of saving the sound of historical musical instruments. However, current digitisation practices are largely inadequate for a deeper understanding of musical instruments, as they have so far been limited to photogrammetric or sampling techniques. The applicant believes that museum collections would benefit from a new approach to digitising musical instruments. A comprehensive understanding of musical instruments can only be achieved by a focused acoustical and mathematical study, ultimately yielding a wealth of efficient and realistic simulation techniques which could be used for real-time emulation: this is the context in which NEMUS will operate. By developing the most advanced mathematical models yet describing sound propagation and transmission in musical instruments, NEMUS will create sustainable, durable and realistic digital emulations of historical musical instruments that are currently out of playing condition. NEMUS will also generate computer-aided simulation studies of a number of harpsichords of the Ruckers/Couchet tradition, to complement organological studies on Ioseph Ioannes Couchet craftmanship. For the first time, complex musical systems will be solved under real-time, on standard consumer hardware, using mainstream numerical methods such as finite difference schemes, including the player’s interaction with the instrument. Appropriate controllers with haptic feedback will be devised, so as to facilitate use in virtual and augmented reality environments.
Race, Church, and Colonial Government in the Atlantic: the case of Angola in the age of Enlightenment (ATLANTIC_ANGOLA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

ATLANTIC_ANGOLA seeks to address the issue of race by analyzing its intersections with religion/church and colonial government in Angola in the second half of the 18th-century/beginning of the 19th century. Being the main provider of slaves to Brazil, Angola had a significant role for the economic success of the Portuguese South American colony, but also in the broader context of the Portuguese empire, due its privileged geographic position in the way between Asia and Brazil. That explains the increasing attention it started to receive from the Portuguese Crown after c. 1750.The aim of ATLANTIC_ANGOLA is to understand the role of the Catholic Church in disciplining and controlling the population, and instilling ideas of racial difference. The project hypothesis is that at least part of the population resisted the disciplining aims of the rulers. That resistance took different forms, but the result was the constitution of a creolized society, mainly in the city of Luanda and its hinterland. The project will contribute to the discussion of the relations between races and perceptions of the “other” in the context of the Portuguese empire. Doing so, ATLANTIC_ANGOLA proposes a path-breaking approach to problems still understudied concerning the history of European colonization of Africa before the 19th century. It will help to develop a better understanding of the historical dynamics of the relations between Europe and Africa over the longue durée. It will also contribute to the historical explanation of the long-term effects of the colonization and the formation of the post-colonial societies, but also to the perception both of the Europeans towards Africa and Africans, and those towards Europe. As to the more tangible outcomes of this project, they include 2 books, 3 articles in major peer-reviewed journals, 1 international conference, a talk series, and the setting-up of an online project.

Keywords: race relations,angola,portugal,18th century,colonial powers,catholic church,creolization,atlantic world,enlightenment,cultural exchanges
willpower – make your own fuel from CO2 (willpower)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 2442500.0
EU funding (EUR): 1709750.0
Participants: 1
Project status: CLOSED

Our vision: we want Europe to be independent of fossil fuels. To turn this ambitious dream into reality, Gensoric targets in a first step a sector which accounts for more than 73% of the fossil fuel usage and 57% of all CO2 emissions in the EU: heating! To overcome this situation, Gensoric aspires to empower private uses to change things actively by themselves. As a means for that, the company introduces ist willpower system: the worldwide first residential CO2 utilization system. It empowers its users to their produce fuel at home from the surrounding atmospheric CO2. The core technology is a patent protected and widely validated electro-biocatalytical process and process technology that runs under ambient conditions. As it uses primarily energy from renewable sources such as installed solar panels or micro wind turbine, the system can also be used as an effective way to store energy from the renewables, but it has a greater capacity than power packs and batteries. During the previous SME-1project its potential to disrupt the conventional energy supply chains was confirmed. Moreover, the market potential of more than 7 bln Euro in alone in Western Europe and the underlying business model (‘ink cartridge’) attracted strategic partners such as one of Germany’s leading energy and utility company, with access to 30 million customers across Europe, who will take over the market introduction once the pilot project has been completed successfully. Outcome of the here proposed SME-2 project is a market ready system with an overall efficiency of 45% and an average capacity to reduce 11kg of CO2 emission per day and user.

Keywords: co2 conversion,renewable energy,independent from fossil fuels,residential heating
Thermal treatment for radioactive waste minimisation and hazard reduction (THERAMIN)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Action type: Research and Innovation actions
Countries involved: Germany,Slovakia,Belgium,Lithuania,Finland,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Research and innovation on the overall management of radioactive waste other than geological disposal. (NFRP-2016-2017-1, 2016)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 3972539.5
EU funding (EUR): 3899939.5
Participants: 12
Project status: CLOSED

Safe management of radioactive waste is challenging to waste producers and waste management organisations. Deployment of thermal treatment in an optimised waste management lifecycle can provide significant volume reduction, waste passivation and organics destruction, with benefits for waste storage and safety cases for geological disposal. Relevant technologies include in-container vitrification, gasification, plasma treatment and hot isostatic pressing. THERAMIN aims in utilisation of all these methods. THERAMIN will provide an EU-wide strategic review and assessment of the value of thermal technologies applicable to a broad range of waste streams (ion exchange media, soft operational wastes, sludge, organics and liquids). THERAMIN will compile an EU-wide database of thermally treatable wastes, will document the strategic benefits of thermal treatment, and will identify the opportunities, synergies, challenges, timescales and cost implications to improve radioactive waste management. THERAMIN will evaluate the applicability and achievable volume reduction of the technologies through ‘first-of-a-kind’ active and non-active full-scale demonstration tests, and will assess the disposability of residues. The project benefits from the large investments made by partners in thermal treatment R&D facilities, which will be used to maximise the benefit across Member states. THERAMIN will benefit from close engagement with an End User Group (waste producers and waste management organisations). The partners will encourage the mobility and training of staff for the development of the next generation of engineers and scientists, and the proposal includes a technical training workshop, a scientific conference, and use of other dissemination tools. THERAMIN will establish a pan-European network of expertise on thermal treatment, will provide for cross-European technology transfer, and will identify prospects for sharing of facilities between countries facing similar problems.

Keywords: innovation,thermal treatment,radioactive waste management,waste minimisation,safety,hazard reduction,interim storage,geological disposal,non standard waste,passive wasteforms
Unveiling Planet Formation by Observations and Simulations (UFOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-06-01
End date: 2023-05-31
Duration (months): 60.0
Total project cost (EUR): 1618125.0
EU funding (EUR): 1618125.0
Participants: 1
Project status: SIGNED

With each newly detected exoplanet system, the planet formation theory is constantly gaining weight in the astrophysical research. The planets origin is a mystery which can only be solved by understanding the protoplanetary disks evolution. Recent disk observations by the new class of interferometer telescopes are challenging the existing theory of planet formation. They reveal astonishing detailed structures of spirals and rings in the dust emission which have never been seen before. Those structures are often claimed to be caused by embedded planets, which is difficult to explain with current models. This growing discrepancy between observation and theory forces us to realize: a novel disk modeling is essential to move on. Separate gas or dust evolution models have reached their limit and the gap between those has to be closed. With the UFOS project, I propose an unique and ambitious approach to unite gas and dust evolution models for protoplanetary disks. For the first time, a single global model will mutually link self-consistently: a) the transport of gaseous disk material, b) the radiative transfer, c) magnetic fields and their dissipation and d) the transport and growth of the solid material in form of dust grains. The development, performing and post-analysis of the models will initiate a new age for the planet formation research. The project results will achieve 1) unprecedented self-consistent precision to answer the question if those novel observed structures are caused by embedded planets or by the gas dynamics itself; 2) to find the locations of dust concentration and growth to unveil the birth places of planets and 3) to close the gap and finally unify self-consistent models of the disk evolution with the new class of observations. Only such advanced models combined with multi-wavelength observations, can show us the process of planet formation, and so explain the origin of the various of planets and exoplanets in our solar neighborhood and beyond.
Providing air traffic data for the drone revolution (OneSkyConnect)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Despite the huge potential of drones to disrupt the global economic, civil and social landscape due to their better endurance, range, safety and cost efficiency over manned aircraft, their full deployment is hindered by restrictive air traffic regulations and misfit air traffic management systems, not designed for the new use case of autonomous drones. OneSky is a multi-award winning Swiss company with a mission to safely and efficiently open the sky to all flying objects. OneSky builds the infrastructure allowing tomorrow’s drone revolution, ensuring their safe integration into today’s aviation world. We offer an online platform, which gathers data from a network of scaled-down control towers collecting maximum of information on the position of every flying object in the sky, manned or unmanned. Our technology will allow virtually everybody to see the air traffic surrounding them and take the most appropriate measures. Thus, what OneSky brings to the aviation world is intelligent air traffic instruments and automatic collision avoidance tools, enabling low-risk flight plans and avoidance strategies and creating a safer smarter sky for all. This will unlock the full potential of drones across many sectors such as Infrastructure, agriculture, mining, surveying, film and industry as well as disaster management among other sectors. OneSkyConnect will facilitate the opening up of lower airspace for drone operation unlocking their full potential which will in turn result in massive economic, environmental and social benefits. Professional drone users lose on average €25k per year per drone because of current restrictions. OneSkyConnect will result in the lifting of these restrictions and opening up of the lower airspace for a multitude of drone applications. The use of drones will reduce complexity, optimise costs and create new business opportunities for the operators unlocking a business potential of €120 billion by 2020.

Keywords: drone,autonomous,collision avoidance,air traffic management,control tower,lower airspace,geo fencing,algorithms,navigation,automatic,network,infrastructure