Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Trapping and Killing Glioblastoma (TrapKill)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1499938.0
EU funding (EUR): 1499938.0
Participants: 1
Project status: SIGNED

Glioblastoma Multiforme(GB) is an aggressive brain cancer associated with a 2% 5-year survival rate and 250,000 new diagnoses globally.Gold standard treatment includes surgical resection and radiotherapy coupled with Temozolomide(TMZ) chemotherapy that promote cancer cell death.Resistance to TMZ and radiotherapy develops rapidly due to DNA repair mechanisms, indicating that targeted disruption of them can potentiate these therapies. TrapKill combines cancer mechanobiology, microfabrication and biomaterials engineering to develop a pioneering therapeutic trifunctionalised hydrogel,physically modified to present 3D microchannels,and chemically functionalised with GB chemoattractant CXCL-12 and TMZ.These promote durotaxis/chemotaxis-mediated GB cell infiltration,constraining cells into elongated morphologies,stressing the nucleus,disrupting DNA repair mechanisms,and rendering cells susceptible to therapies. I have shown that 3D patterned hydrogels promote GB GL261 cell infiltration,forcing cells to adopt a filamentous conformation and subjecting the cell nuclei to significant shear/tension/compressive forces.Following microchannel sequestering,preliminary data indicate that cells upregulate stress-related signalling processes and lose the protective effects of cell agglomeration.It is envisaged that TrapKill glioblastoma therapy will significantly enhance the efficacy of gold standard chemo-radio-therapy approaches. TrapKill objectives include: •A chemoattractant-TMZ functionalised and micropatterned hydrogel to create TrapKill therapy •Analysis of microchannel dimensions on GB cell morphology,nuclear stress and cell sensitivity to TMZ/gamma radiation in vitro •Assess transcriptome changes in mechanically stressed GB cells and in DNA repair gene transcription •Pre-clinical resection-radiation murine GB model assessment TrapKill will create a transformative GB treatment,with a combined approach to significantly revolutionise existing/next-generation GB therapies.

Keywords: biomaterials,mechanobiology,glioblastoma,biomedical device,patterning,neural interfaces
Entangled Histories of the Proximal Senses (1350-1650): A Mediterranean History of (Subjective) Knowledge (PROXISENSES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1999567.5
EU funding (EUR): 1999567.5
Participants: 1
Project status: SIGNED

The proximal senses—taste and touch—were linked historically to the body, femininity, and subjectivity. This both fed adverse socio-cultural, religious, and gender stereotypes and allowed the voices of women, subaltern subjects, and Mediterranean people to be dismissed as irrelevant to knowledge-making. It also influenced modern scholarship, which has given undue weight to sight and the observation practices of seventeenth-century Northern European men as signals of the advent of modern science. PROXISENSES challenges this narrative, arguing that other forms, eras, and practitioners of experimental practices also contributed much to the production of knowledge about the natural world. Building on histories of the senses, food, knowledge, and the Mediterranean, it breaks new ground with three key questions, each tied to a research objective (RO). RO1 Practices: What was the epistemic value of the proximal senses before the alleged Scientific Revolution (i.e., 1350–1650)? RO2 People: To what extent did manual workers (e.g., fruit sellers, farmers, fishmongers, miners, winemakers) contribute to a better understanding of plants, minerals, and animals? RO3 Knowledge: What impact did a millennium of cross-cultural encounters in the Mediterranean have on the construction of sensory knowledge? To address these issues, PROXISENSES uses three food subprojects to investigate touch and taste across the Mediterranean. Each food represents a main category used to classify the natural world: salt (minerals), grapes (plants), and fish (animals). Explored through diverse, scattered primary sources using digital and archival methodologies, the subprojects offer both transversal joint food histories and detailed microhistories. By unearthing previously invisible knowledge-makers, PROXISENSES contributes to the urgent need to decolonise histories of science by offering a transformative vision of the genesis of empirical practices that are central to our view of natural sciences today.

Keywords: sensory history history of touch history of taste history of knowledge food history mediterranean history
Innovation Residues – Modes and infrastructures of caring for our longue-durée environmental futures (INNORES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2497210.0
EU funding (EUR): 2497210.0
Participants: 1
Project status: SIGNED

Innovation residues designate those left-behinds of innovations that profoundly shape human lives as they stay with us for a long time–well beyond moments of production and consumption, and well beyond the time horizons considered when assessing the worth of innovations. Residues are material witnesses to culture and practice of innovation, to diverse politics at work, and to the limited attention to long-term sustainable futures in a world predominantly shaped by short-term impact thinking. Today, as technological innovations are seen as foundational to the future development of contemporary societies, the entanglements of innovation and society require closer scrutiny more than ever. INNORES offers a novel, empirically and theoretically rich approach to do so through a radically switched perspective. It does not put innovations themselves centre-stage, assigning to residues the role of potentially disruptive side-effects, but takes residues as the lens to study democratic innovation societies. It investigates how societies conceptualise, make sense of, live with, and care for innovation residues, and how this shapes their relations to innovation. Studying innovation societies through the complex networks and manifestations of residues, INNORES opens up new perspectives on how local choices and global impacts relate, on intergenerational justice and responsibility, on whose future imaginaries, values, and knowledges count when making choices, on how benefits and risks are distributed, and on modes and infrastructures of care for environmental futures. INNORES engages with three very different kinds of residues–nuclear waste, microplastics and data waste. Using a specifically tailored qualitative, comparative mixed-method approach, it investigates them in different arenas spanning three European countries and the EU. Studying these particular sites in detail will then allow to trace out connections to and implications for innovation societies more generally.

Keywords: responsible innovation valuation waste innovation residues anticipation futures matters of care
Engineering an integrated platform for generation of human blood stem cells from pluripotent sources (MakingBlood)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,Netherlands,Finland
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-07-01
End date: 2031-06-30
Duration (months): 72.0
Total project cost (EUR): 9919393.0
EU funding (EUR): 9919393.0
Participants: 5
Project status: SIGNED

Life-saving blood cell replacement depends on voluntary donors. Availability is a challenge for specific groups, and 25% of patients needing blood stem cell transplants lack a compatible donor. The ideal alternative is clinical-scale production of Haematopoietic Stem Cells (HSC) from laboratory-maintained tissue-compatible sources, to provide an off-the-shelf source of blood cells. HSC are generated in the aorta/gonad/mesonephros region of the embryo, expand in the foetal liver, and are maintained in the bone marrow of adults. Current attempts to generate HSC in vitro do not consider the changing cellular, chemical, and physical characteristics of the different environments met by HSC in vivo from embryo to adult, and have been unable to reliably produce functional HSC. MakingBlood aims to establish a proof-of-concept platform for robust generation of human HSC from pluripotent stem cells by developing a self-organising gastruloid model of embryonic HSC generation without genetic manipulation, and successively recapitulating the natural foetal and adult HSC development environments. MakingBlood brings together an expert in HSC embryonic development, a national blood bank research director with expertise in adult HSC, an expert in molecular regulation of cell fate choices, and a bioengineer with expertise in mechanical and chemical integration for tissue production to deliver this breakthrough platform. By using state-of-the-art technology and multidisciplinary approaches, we will systematically detangle cellular, chemical, and physical properties of natural HSC generation, amplification and maintenance microenvironments, and iteratively identify essential elements that enable and promote HSC function. We will integrate key elements into modular scalable engineered niches to establish a HSC production platform, which can be developed as a bioreactor for on-demand blood production, and eventually replace donations as the clinical source of HSC and mature blood cells.

Keywords: gastruloids,engineered stem cell niches,mechanobiology,hematopoietic stem cells,developmental hematopoiesis
Identifying future capabilities for Community Policing (KOBAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Research and Innovation actions
Countries involved: Netherlands,Poland,Spain,Portugal,France,Czechia,Belgium,United Kingdom,Cyprus,Estonia,Greece,Finland
Call: New methods and technologies in service of community policing and transferable best practices (HORIZON-CL3-2023-FCT-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 3626353.75
EU funding (EUR): 3626353.75
Participants: 19
Project status: SIGNED

Across Europe society is changing due to demographic, technological and economic developments. Communities are getting more diverse, both in real life and online. This challenges Law Enforcement Agencies (LEAs) to engage with, and to reassure, communities about safety and security matters in a trustful way. The changing status quo is significantly shaping perceptions of policing, requiring adaptive strategies. To address these challenges, the KOBAN project will create an innovative, research and practice-based Community Policing (CP) initiative, adopting an evidenced based approach.It will focus on co-creation and collaborative security between LEA and non-LEA community members, leading to mutual trust and respecting each other’s contributions. This results in a greater sense of security, whilst contributing to an overall increase in the efficiency and effectiveness of securing all communities including those who are often considered hard to reach and engage. KOBAN’S Capability Model will identify proven methodologies, models, technologies, tools and best practices, and use them as a foundation for future proactive, co-active and reactive CP capabilities. This knowledge will help to build the AI Assistant as well as the App Factory for the development of further CP tools, methods and solutions tailored to the needs of stakeholders and adhering to social, legal, cultural, ethical and gender equality standards. These will be tested and validated in six pilot projects throughout Europe. KOBAN will support capacity building, embedding knowledge, skills and capabilities within organisations and communities leading to bespoke training for both police personnel, municipalities and citizens. In short, KOBAN will lead a cultural and organisational transformation that address current fundamental barriers to effective community policing. With its Capability Driven Approach, KOBAN is setting the stage for future-proof community policing, both online and in the real world.

Keywords: community policing,evidence based approach,capability driven approach,co creation,best practices,transferability,ai assistant,lea citizen collaboration,field tests,crime prevention
Prefabricated Mature Blood Vessels and Tools for Vascularized 3D Cell Culture (Vasc-on-Demand)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: EIC Transition Challenge: Full scale Micro-Nano-Bio devices for medical and medical research applications (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 2488750.0
EU funding (EUR): 2488750.0
Participants: 1
Project status: SIGNED

In 2020, the cell culture market was valued at $19 billion USD, with consumables comprising more than 60% of the market. The emerging 3D cell culture provides lucrative business opportunities for consumables and tissue test models, but current technology and market supply lack an easy and reliable tool for the uncomplicated creation and cultivation of vascularized and perfusable artificial 3D tissue. The current 3D cell culture consumable market offers only well plate inserts and organ-on-a-chip systems for generating 3D tissues, which are limited regarding tissue mimicry and complexity. Bioprinting, while promising, is still unreliable for reproducible vascularized tissue engineering. The EIC Transition Proposal Vasc-on-Demand aims to fill this gap by providing three easy-to-use laboratory products for the generation and cultivation of perfusable vascularized 3D tissue: 1. BasicVasc: An all-in-one bioreactor consumable for generation and cultivation of perfusable tissue culture 2. EasyVasc: Prefabricated ready-to-use vessel channel networks without cells 3. CompleteVasc: Prefabricated matured cell-containing vascularization EasyVasc and CompleteVasc both build on the BasicVasc technology. Therefore, BasicVasc will be advanced for high-throughput production of precisely manufactured structures to be ready for the market. The other products will be fully developed and characterized to allow improved vascularized tissue production with even more advanced and simpler ready-to-use systems. This grant will be carried out by a highly motivated team with synergistic expertise in technology, product engineering, and business development, working towards the foundation of a start-up for the commercialization of the technology. The proposed Vasc-on-Demand has the potential to simplify the development of sophisticated test models for research and pharmaceutical approaches like drug testing, leading to reduced animal trials and development costs.

Keywords: tissue engineering,vascularization,perfusion,organ on a chip,3d cell culture,biofabrication
Acorai Heart Monitor - Non-invasive multi-sensor device for heart failure monitoring (AHM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-10-01
End date: 2025-05-31
Duration (months): 20.0
Total project cost (EUR): 3358822.91
EU funding (EUR): 2299633.0
Participants: 1
Project status: CLOSED

Heart Failure is a progressive clinical syndrome with multiple etiologies. It is associated with nearly three million hospitalizations in the EU annually, representing 30% of all readmissions, and accounts for up to 5% of the entire healthcare expenditure. Despite modern medical treatment, HF is a life-threatening and debilitating condition with a poor prognosis. The Acorai Heart Monitor (AHM) is a monitoring device designed to detect and estimate hemodynamic parameters non-invasively. AHM is a handheld electronic device that features multiple sensors to collect data from 4 sensor types based upon patented the SAVE sensor system to estimate the absolute pressure of the heart failure patient's cardiac system. The sensor data are processed within the medical device with machine learning (ML) methods, the results are then displayed to be read by a qualified healthcare professional (HCP). Delivering Intracardiac pressure to HCPs to guide the treatment of patients with HF leads to improved quality of life. It lowers the frequency of hospital admissions, yet all current tools require an invasive procedure. AHM is a multi-patient non-invasive device that would dramatically disrupt the paradigm of HF treatment and lead to significant cost saving in the EU whilst improving the overall prognosis of patients who suffers from HF. With the growing prevalence of HF globally the AHM is a tool with applicability in multiple workflows and represents a first-of-its-kind device to revolutionise HF management. AHM has already been validated in 300 patients in a Swedish proof of concept study and now needs the support to bring this device to market and collect data via a large multi-national study to prove its effectiveness. The AHM is fully patent protected with three granted patent families and four patents pending covering the core components of the device and its clinical application. This is additionally protected by large proprietary datasets and a unique ML model.

Keywords: non invasive intracardiac pressure monitoring icpm for heart failure hf management
Development of heating technologies for the Efficient renewable Energy COnsumption of CO2-neutral DOWNSTREAM-processes (E-ECO Downstream)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Clean Steel (co-programmed)
Countries involved: Sweden,Italy,Germany
Call: CO2-neutral steel production with hydrogen, secondary carbon carriers and electricity OR innovative steel applications for low CO2 emissions (Clean Steel Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 4940583.76
EU funding (EUR): 4940583.75
Participants: 8
Project status: SIGNED

The aim of E-ECO Downstream is to enable a clean steel production by developing advanced and breakthrough technologies for the steel making downstream processes. This will decisively support the EU in achieving its goal towards climate neutrality by 2050. E-ECO Downstream focuses on the efficient utilization of hydrogen, biogas, and electricity to substitute carbon-based fuels and drastically lower the carbon footprint of the steel production. Energy efficiency is pursued to enable sustainable utilization of volatile green energy. Currently installed burners of reheating furnaces will be enabled to utilize green H2 by integration of newly designed and 3D-printed burner components instead of replacing entire burner systems. To increase fuel flexibility hybrid heating concepts (H2 and electricity) will be investigated in a pilot walking beam furnace. Since the mentioned solutions will change the waste heat streams and their heat recovery in future downstream processes must be reevaluated. This will be done by analysing the partners processes and plants, development and testing of waste heat recovery concepts and recuperators regarding their suitability to new fuels and their off gases, while considering their impact on materials/product. Energy efficiency potentials of downstream processes will be evaluated by case studies for the application of hot charge from casting to hot rolling by covering of the slabs with passive and active panels. The elaborated solutions will be assessed by techno-eco-environmental analysis to evaluate their applicability and to increase their acceptance in the steel community. The E-ECO Downstream consortium has a deep and shared knowledge of iron and steel making, downstream processes and heating technology, materials engineering, numerical simulation, experimental investigations, economy, and life cycle analysis.

Keywords: decarbonization of steel production,downstream processes,heating furnaces,h2 usage,hybrid heating,waste heat recovery,hot charging