Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From Research Optoacoustic Novelty To Imaging Established in Routine diagnostics (FRONTIER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 3581601.23
EU funding (EUR): 2451121.0
Participants: 1
Project status: CLOSED

Multispectral optoacoustic tomography (MSOT) is an innovative biomedical imaging technology that allows for molecular imaging in deep tissue. This noninvasive technology enables assessment of the concentration and distribution of a variety of clinically important molecules in the body and uniquely delivers information of e.g. oxygenation, inflammation, and fibrotic changes. MSOT has already demonstrated significant scientific and clinical value across a range of diseases and applications, making it a promising tool to diagnose diseases and monitor treatment response. Despite these early successes, the technology is not yet commercially viable on the broad clinical market and currently remains effectively confined to a research environment. FRONTIER will provide iThera Medical the means to translate an optimized MSOT system (MSOT Frontier) from a research environment to application in routine clinical imaging, thereby providing clinicians worldwide a powerful new diagnostic tool.

Keywords: optoacoustic imaging,biophotonics,biomedical imaging,breast cancer,neuromuscular disease,inflammatory bowel disease,noninvasive imaging,molecular imaging
Allogeneic Macrophages for Cancer Therapy (ONCOMAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-05-01
End date: 2023-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Macrophage cell therapy can become an attractive example of a cell therapy, with numerous potential applications, among them cancer therapy. While T-cell based therapies – so successful for the treatment of hematological malignancies! – have yet failed to demonstrate effectiveness in the treatment of solid tumors, macrophages are a key component of the tumor microenvironment (TME), and in principle they are capable of killing solid tumor cells. However, wildtype macrophages commonly respond to the TME by acquisition of a M2-like polarization state, in which state they rather support tumor growth and metastatic spread. This is a first problem for macrophage cell therapy against cancer. Besides, unlike T-cells, human macrophages cannot be expanded in cell culture, resulting in insufficient numbers of obtainable macrophages and thus limiting their utility for cell therapy. We have generated genetically engineered human macrophages, which have proliferative potential, are resistent to tumor-induced repolarization and thus demonstrate oncolytic activity. We want to translate these exciting findings into a cell-therapy against cancer. ONCOMAC relates to the preparation for and design of a preclinical proof-of-concept study for these genetically engineered human macrophages, so that we will have a sound basis for the translation of our genetically engineered macrophages into clinical trials. In particular, ONCOMAC will establish the numerous complex analytical procedures which are required by the European Medicine Agency's regulatory framework for “First-in-human” studies of an ATMP (Advanced Therapy Medicinal Product).
Building a climate-resilient safe operating space for coral reef fisheries to tackle malnutrition in the global tropics (SAFEReefs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Coral reef fisheries prominently feature in the delivery of nutritional benefits (e.g., essential amino acids, fatty acids, vitamins and minerals) throughout the tropics, with over 500 million people, mostly in low and middle-income countries, estimated to depend on reefs for food and income. However, our lack of understanding on how to effectively manage reef fisheries in the context of environmental change is leading to unsustainable reef-based food systems and reduced income for dependent populations, exacerbating malnutrition in tropical coastal communities. Innovative fisheries management tools are needed that simultaneously enhance ecosystem resilience and the multiple ecosystem services coral reefs provide to human populations. SAFEReefs aims to empirically develop, for the first time, a climate-resilient safe operating space (SOS) for data-poor reef fisheries so reefs can be sustainably managed in multiple dimensions (e.g., ecologically, economically and nutritionally) under a rapidly changing environment. Using a global dataset covering >2000 reefs worldwide and capturing community composition shifts experienced under climate change, this project will (i) estimate sustainable reference points for reef fisheries that account for the interconnections between nutrient supplies, ecological stability and economic gains; and (ii) conduct the first global assessment of coral reef fisheries sustainability and climate-resilience, pinpointing the ecosystem, nutrition and economic potential of applying climate-resilient reef fisheries globally. Overall, SAFEReefs will generate new knowledge, contribute towards an evidence-based online decision support tool to help end-users (e.g., fisheries stakeholders) manage their reef fisheries, and reveal novel interdisciplinary solutions to help tackle the ongoing climate and health crisis experienced by many coastal populations around the globe.

Keywords: ecosystem based management,coral reefs,climate resilience,safe operating space,human dimensions,sustainable exploitation,marine systems modelling,reef fishes,solution based research
CARNIvoran MORPHological and Functional Diversity (CARNIMORPH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-01
End date: 2028-11-30
Duration (months): 36.0
Total project cost (EUR): 420966.72
EU funding (EUR): 420966.72
Participants: 2
Project status: SIGNED

The CARNIMORPH project aims to unravel the evolutionary and ecological dynamics shaping carnivoran craniodental diversity by investigating form-function relationships and modularity/integration. Teeth are crucial for acquiring and processing food, offering a valuable window into predator-prey interactions, dietary specializations, and ecological adaptability over time. Despite the significance of carnivoran teeth, no comprehensive ecomorphological study has yet been undertaken to quantify the modularity and functional efficiency of their diverse dental forms. To address this gap, CARNIMORPH will employ cutting-edge methodologies, including high-density 3D geometric morphometrics, advanced digitization techniques, and experimental mechanical testing, to study the biomechanical, dietary, and phylogenetic factors underlying the evolution of carnivoran dentition. By quantifying tooth shape with unprecedented accuracy, CARNIMORPH will disentangle the relative contributions of diet and phylogeny to tooth form, while also investigating ecomorphological convergence across extinct and extant species. Furthermore, a new protocol for conducting slicing and crushing simulations will be developed to assess the efficiency of carnivoran teeth and quantify the trade-offs between these two critical functions. The project will be hosted at UC Berkeley and Universidad de Málaga, leveraging state-of-the-art facilities and expertise in functional anatomy, evolution, and biomechanics. CARNIMORPH's findings will advance our understanding of the diversification and adaptive strategies of carnivorans across macroevolutionary timescales, contributing valuable insights into the evolutionary mechanisms that shaped current biodiversity. The outcomes will align with key priorities of the MSCA Work Programme by fostering innovative research, promoting international collaboration, and addressing important scientific questions on the intersection of evolution, ecology, and biomechanics.

Keywords: carnivorans,ecomorphology,functional morphology,macroevolution,palaeobiology,biomechanics,fossil record
Increase the Synergy among different ENERGY NETworkS (SENERGY NETS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Germany,France,Italy,Belgium,Slovenia,Sweden,Spain,Austria
Call: Energy Sector Integration: Integrating and combining energy systems to a cost-optimised and flexible energy system of systems (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 9938450.75
EU funding (EUR): 8223108.66
Participants: 20
Project status: SIGNED

SENERGY NETS aims at demonstrating the technical and economic capability of multi-energy systems to decarbonize the heating and cooling, power and gas sectors through renewable energy sources produced locally as well as sector integration, by primarily focusing on promising infrastructure and business models. To do so, SENERGY-NETS will develop a set of tools and platforms (up to TRL7/8) aimed to optimise the planning of District Heating and Cooling as well as distribution grids with sector coupling consideration and allow the provision of flexibility services to Distribution and Transmission System Operators. These solutions will be implemented on three pilot sites located in Milan (IT), Ljubljana (SI) and Paris (FR) and their replicability will be tested in two additional real case studies presenting alternative climatic, economic and geographic conditions in Västerås (SW) and Cordoba (ES). The SENERGY NETS solutions will be adapted to the main stakeholders at the different phases of the projects development involving sector coupling: long term planning, design and simulation, operational planning, valorisation, evaluation and replication. The project will evaluate the benefits through a consolidated methodology developed to estimate the overall value created by sector integration, relying on the current economic, regulation and market rules and assess the impacts on the European power system. SENERGY NETS relies on a strong trans-disciplinary consortium involving 17 organisations located in 7 European countries, involving renowned experts from public authorities, infrastructure providers, research institutions, entrepreneurs and consumers associations. Altogether, they will provide the necessary knowledge, expertise and capacities to develop, demonstrate and evaluate developed tools and services enabling the integration of multi-energy systems to provide flexibility to the power system, and ultimately enable the decarbonisation of the energy system.

Keywords: multi energy systems,sector integration,sector coupling,flexibility services,decarbonisation of the district heating and cooling,power and gas sectors
Revealing the BActerial Response to Temperature and Antibiotics Stress via multiscale imaging (BARTAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Antibiotic resistance is one of the biggest scientific and health challenges of our time. If actions are not taken, antibiotics resistance infections will become the first cause of death by 2050. One of the most common signs of bacterial infection is a rapid increase of the host temperature that exposes bacteria to a heat shock (HS). To survive and quickly adapt to this new environment, bacteria activate the synthesis of specific proteins, called heat shock proteins (HSPs). In E.coli, HSPs expression is mediated by the alternative sigma factor sigma32 (Sig32). The molecular processes that are associated with the bacterial stress responses induced by a combination of change in temperature and presence of antibiotics have not yet been investigated in detail due to the technical challenges of monitoring this combination of stresses with the necessary temporal and spatial accuracy. Cell-to-cell fluctuations in protein expression could affect single cells survival. Therefore, these processes should be studied with single cell precision. I propose to investigate bacterial responses to the combined stresses of temperature increase and antibiotics at single cell level in live E.coli using a combination of microfluidics and single molecule/super-resolution imaging. I will design and build a microfluid system able to control the stress landscape of temperature and antibiotic concentrations. This will allow me to study Sig32 expression during HS using fast-maturating fluorescent protein fusions. Next, I will monitor how HS affects proteins synthesis by measuring the diffusion changes of single ribosomal subunits (S30 and S50) during HS, using single particle tracking PALM. Finally, I will quantify the interplay between HS response and antibiotic susceptibility by monitoring Sig32 levels and the diffusion of ribosomal subunits. Taken together my results will provide for the first time a quantitative picture and a new framework to study bacterial response to multiple stresses.

Keywords: bacterial stress response,single molecule microscopy,super resolution microscopy,heat shock,antimicrobial resistance
Real Time 2D Polymerization studied using Atomic Force Microscopy (RAPID-AFM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium,Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: TERMINATED

Two-dimensional polymers are a crucial category of low-dimensional materials that have garnered significant attention from both academia and industry. Despite the synthesis of various types of 2D-COFs reported in the literature, there remains a significant gap in our fundamental understanding of their nucleation and growth mechanism on the surfaces. High-Speed atomic force microscopy (HS-AFM) offers the potential to observe molecular processes in real-time, providing valuable insights into single-molecule dynamics. This project aims to develop scientific and technical methodologies for investigating 2D polymerization processes using HS-AFM on solid surfaces. I target the acquisition of qualitative as well as quantitative data in relation to the nucleation, growth and ripening phenomena transpiring during 2D polymerization. This research will shed light on numerous unknown aspects of dynamic covalent chemical reactions occurring on solid surfaces, which often differ substantially from those in solution or bulk. Complementary techniques such as XPS and AFM-IR will be employed to chemically characterize the material. This comprehensive approach will enhance our understanding of surface-based 2D COF design. The quantitative insight obtained into the 2D polymerization processes will be used to fabricate large domains of defect-free polymer films on various surfaces such as SLG-Si/SiO2, h-BN and mica. The high quality polymer films formed on dielectric substrates would pave way for the direct characterization of their electrical properties such as charge carrier mobility.

Keywords: scanning probe microscopy,covalent organic framework,boronic acid,thin film,2d polymer,molecular dynamics,solid liquid interface
Unraveling the relative location of mixed-metals in multivariate metal-organic frameworks for tailor-made photocatalytic tandem reactions (MUVCATMOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Photocatalytic reduction of carbon dioxide (CO2) is a promising approach for mitigating CO2 emission and transforming it into chemical energy and value-added chemicals. In this context, porous materials, particularly metal-organic frameworks (MOFs), have emerged as tailor-made solids with desired structural arrangement representing the most attractive candidates due to their high tunability compared to traditional inorganic solids. These structures are ideal platforms for introducing heterogeneity to enrich the chemical environment in multivariate (MTV) frameworks. Among them, mixed-metal MOFs are of high interest due to the inherent properties of each metal that can be incorporated and combined into the same material. Herein, MUVCATMOF proposes using MTV-MOFs composed of mixed-metals for tailor-made photocatalytic tandem reactions to transform CO2 into value-added chemicals. The idea is based on creating a highly active catalytic pore environment in the structure where the chemical activity of each metal will be exploited towards each catalytic reaction and coupled the products synergestically. In this specific case, three active sites will be designed for tandem reactions of the CO2 photoreduction into carbon monoxide (CO), hydrogen (H2) generation, and subsequent coupling of CO and H2 into hydrocarbons or alcohols. This research project consists of three individual objectives. The first objective is to develop new methodologies for the controlled synthesis of MTV-MOFs. The second objective is to establish novel characterisation techniques to understand the relative location of mixed-metals in MTV-MOFs. The third objective is demonstrating the photocatalytic CO2 reduction and subsequen tandem reactions of tailor-made MTV-MOFs. This research's originality will provide novel rational design tools and characterisation techniques for the controlled formation of MTV-MOFs, contributing to a higher activity and selectivity of catalytic tailor-made materials.

Keywords: metal organic frameworks,reticular materials,multivariate,mixed metal,co2 photoreduction,tandem reaction
Inverse Design of Metal-Organic Framework Catalysts (IMOCAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 2
Project status: SIGNED

Metal-organic frameworks (MOFs) are a class of crystalline porous materials composed of metal nodes connected by organic linkers. The atomically precise structures of most MOFs offer the opportunity to use them as catalysts that can be fine-tuned for a specific chemical transformation. However, the primary challenge is their near-infinite combinatorial design space resulting from the large variety of possible building blocks and the diverse ways they can be assembled. This complexity makes it extremely difficult to identify a MOF catalyst tailored to a given application. Computational modeling has emerged as a key tool to sort out this myriad of possibilities and guide experimental efforts. However, straightforward computational screening approaches, the most widely used strategy thus far, often prove impractical for exploring the vast combinatorial space of MOF catalysts. To address this challenge, the research project IMOCAT will devise a protocol to efficiently search the massive chemical space of possible MOFs which will enable the inverse design of new and better catalysts for selective ethylene oligomerization, an important reaction in the petrochemical industry. To this end, cutting-edge computational tools will be integrated with a genetic algorithm that allows for simultaneous optimization of MOF building blocks to achieve the desired activity-selectivity tradeoff. The overarching goal of the IMOCAT project is to derive pragmatic and experimentally relevant catalyst design principles by analyzing the lead MOF candidates. These principles will then guide experimental researchers in synthesizing MOF catalysts with improved performance for selective ethylene oligomerization.

Keywords: metal organic frameworks,computational catalysis,inverse catalyst design,genetic optimization of catalysts,ethylene oligomerization