Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Window to the brain: a game changer in the discovery of human neuronal circuitry, cellular heterogenicity and biomarker profile indicative of early Alzheimer's disease -related pathology (HUMANE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1998389.0
EU funding (EUR): 1998389.0
Participants: 1
Project status: SIGNED

The molecular mechanisms leading to Alzheimer's disease (AD) are poorly understood. This is due to lack of human tissue samples for research representing early changes of AD pathology. The accumulating pathology, including beta-amyloid and tau proteins, are manifested by concomitant neuroinflammatory reactions geared by malfunctional microglia. Microglia in the human and mouse AD brain exist in various subpopulations from which a specific, disease-associated microglia population is thought to be involved in AD pathogenesis. However, there is no evidence on whether and how these specific microglial subpopulations actually impair neuronal functions in human AD brain. I will now assess neuron-glia network activities and functions indicative of early AD pathology in humans. I hypothesize that early AD pathology selectively impairs neuronal circuits and that glial cells, especially specific microglia subpopulations, contribute to neuronal dysfunction and cognitive decline. These events contribute to a detectable vesicle-based biomarker profile in cerebrospinal fluid and blood prior the clinical disease. Due to early AD pathology present in a subpopulation of idiopathic normal pressure hydrocephalus (iNPH) patients, the brains of the iNPH patients offer a unique window to evaluate cellular and molecular events occurring during early AD. I combine a series of state-of-the art techniques to answer how and what glial cell subpopulations are associated with altered neuronal network activities at subcellular and spatial resolution in human brain impacted by early AD-related pathology. Novel methodologies established in my lab, knowhow and access to unique brain samples make me uniquely positioned to form a holistic view on how early AD-pathology impacts cellular functions at multiple levels. This will pinpoint novel molecular targets for further validation and new fluid biomarkers.
Catalysation of institutional transformations of Higher Education Institutions through the adoption of acceleration services (CATALISI)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Italy,Ireland,Belgium,Lithuania,Spain,Poland,Greece,Netherlands
Call: Acceleration Services in support of the institutional transformation of Higher Education Institutions (HORIZON-WIDERA-2022-ERA-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 3219156.25
EU funding (EUR): 3219156.25
Participants: 12
Project status: SIGNED

The overall aim of CATALISI is to help and support Higher Education Institutions to successfully implement a strategy and individual pathway for institutional transformation through the adoption of acceleration services. These are designed to facilitate and accelerate institutional transformations in the field of Research and Innovation which will strengthen European Universities collaborations and alliances as lighthouses of European values. CATALISI will analyse how the governance of Higher Education Institutions can be changed, considering the governance as a way in which societal and state actors intentionally interact in order to transform Science Technology and Innovation systems, by regulating issues of societal concern. WP1 will ensure the co-design and implementation of Acting-LL throughout the project. The knowledge and information produced in the WP1 will serve as a basis for the creation of the Knowledge sharing and mutual learning programme in the framework of WP2. The knowledge and information produced in WP1 will also support the activities of WP3 that will guarantee the design, the implementation and the sustainability of the institutional transformations. The whole process will be constantly monitored and assessed through WP4 that will develop monitoring and assessment toolkits to keep track of the progress related to the Institutional Transformations through the adoption of acceleration services, along the 3 Domains defined by CATALISI. WP4 will also provide strategic information and guidance, through policy recommendations about the structural and institutional changes that are needed to maximize the value of research and its impact within the European region.WP5 and WP6 are cross-cutting and linked to all other WPs’ activities (communication and management). CATALISI will be carried out by a consortium integrating 11 partners from 8 EU Member States, covering different geographical areas of Europe, 3 of them from Widening countries.

Keywords: acceleration services,rri,open science,gender,research carrers,higher education institutions,institutional transformation
Evolutionary feedback between traits and species diversification: convergence and divergence in sympatric butterflies of the Amazonian rainforest (OUTOFTHEBLUE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1991768.0
EU funding (EUR): 1991768.0
Participants: 2
Project status: SIGNED

This project will bridge gaps between micro and macro evolution by ascertaining the evolutionary feedbacks between trait and species diversification, focusing on closely-related species living in sympatry. Sympatric species often differ in suites of traits involved in niche partitioning: how do ecological interactions induce the sequential evolution of series of traits? In turn, how does phenotypic divergence open up new niches and fuel sympatric speciation? The project focuses on the neo-tropical butterfly genus Morpho where multiple behavioural and morphological traits strikingly differ between sympatric species living in the canopy vs. understorey. Studying trait variations within and among these closely-related species living in sympatry allows reconstructing the evolutionary steps leading to the divergence in suites of traits linked to niche specialization. Within the understorey clade, striking parallel geographic variations are observed among sympatric species, resulting in repeated local convergences in iridescent blue wing patterns, that may be driven by mimicry among these fast-flying, conspicuous butterflies. Such evasive mimicry may induce costly reproductive interferences, favouring segregation of circadian activities between species and thus contributing to the speciation process. The project relies on the original combination of both up-to-date and field-based approaches: (1) cutting-edge phenotypic characterisation of complex traits (eg. iridescence, flight) (2) empirical estimations of selective forces with wild butterflies (3) machine learning-based population genomics applied to demographic inferences (4) and mathematical modelling of density-dependent processes with stochasticity. These innovative approaches will shed light on unrevealed ecological interactions between species, impacting diversification of traits and species, therefore bringing major scientific breakthrough and attracting society attention on biodiversity loss in Amazonia.

Keywords: mimicry,speciation,phenotypic diversification,mate choice,reproductive interference
Study and interpretation of historical natural dye formulations for the modern textile design (SCARLET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499697.0
EU funding (EUR): 1499697.0
Participants: 1
Project status: SIGNED

The textile industry faces significant environmental challenges. In response to the increasing demand for sustainable practices and the European Union’s Sustainable Development Goals, SCARLET project aims to revolutionise the textile community by optimising historical recipes for eco-friendly applications. By investigating historical dyeing techniques, SCARLET aims to bridge the gap between traditional practices and modern sustainability standards. This research will validate the eco-friendliness of these recipes and provide practical solutions for SMEs, designers, artists, and the wider textile community seeking alternatives. This will be addressed in the following key points: 1) Heritage and Innovation: SCARLET will combine traditional knowledge with contemporary research to create sustainable dyeing practices. 2) Community Empowerment: The project empowers the textile community to incorporate natural dyes into their work by developing accessible resources. 3) Environmental Impact Reduction: SCARLET will address the oversight of colourants in current sustainability guidelines, offering solutions that significantly reduce the ecological footprint of textile production. SCARLET will undertake a comprehensive approach that begins with an in-depth study of historical dyeing recipes from the 15th to the 18th century across Iberia, Italy, England, and France. The project will focus on interpreting, reconstructing and analysing historical recipes and assessing their suitability for contemporary use. Finally, recognising the gap between historical knowledge and contemporary practice, SCARLET will establish a creative hub, which will provide accessible resources and workshops, empowering the textile community to harness the full potential of natural dyes. By combining historical insights with cutting-edge research, SCARLET addresses the sustainable transformation of textile production while fostering a deeper appreciation for cultural heritage.

Keywords: wool natural dyes sustainable design eco friendly formulations
Reuse of excavated soil in 3D printing of sustainable earth-based mixtures for low energy buildings (RePrintCLAY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-09-30
Duration (months): 25.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

Modern construction materials are energy-intensive, and therefore, the construction industry can reduce emissions by developing alternate building materials and adopting innovative construction technologies. There is an upsurge of interest in earth building technologies, but there are associated limitations such as labour cost and construction time. On the other hand, the construction and demolition of infrastructure produce a surplus of excavated soils that ends up at landfills. In this scenario, processing these soil wastes locally and integrating them in buildings as earth-based construction materials using 3D printing technology is an ideal solution. Therefore, the project assesses the technical feasibility of reusing the excavated soil, for producing earth-based composites, with sustainable additive combinations for enabling 3D printing. An industrial by-product such as Ground Granulated Blast-furnace Slag (GGBS) is proposed as an additive with other inorganic admixtures in trace quantities for treating the soil. The rheological parameters, the time-dependent green strength development characteristics and the long-term compressive strength characteristics of the soil treated with additives will be studied. The microstructure of the hardened earth mixes will be used for explaining their mechanical performance. The project will deliver promising earth mix combinations that are environmentally friendly, printable and made from by-products resources and excavation soil wastes. The outcomes of the project will be instrumental in delivering the decarbonization goals of the construction industry. This project is supported by the excellent research environment provided by the host, Dr Perrot at UBS and Prof. Habert at ETH Zürich, with state-of-the-art facilities for research development, testing and training. This project offers unique scientific opportunities that enable the candidate to return to mainstream research and excel in future career perspectives.

Keywords: clay minerology,3d printing,rheology,lca,sustainable engineering,excavated soil,reuse,geotechnical engineering,microstructure,testing of materials
Impact of Climate Change on Pavement Durability: Role of Ultraviolet Radiation Ageing of Bitumen (Climate-Pave) (Climate-Pave)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 3
Project status: SIGNED

The Climate-Pave project aims to train a researcher through interdisciplinary research focused on understanding the ultraviolet (UV) radiation ageing mechanisms of bitumen, the key binding material in pavements. This initiative addresses the challenges posed by climate change by enhancing the durability and performance of road infrastructure under increasing UV exposure. The project will investigate the impact of UV radiation on bitumen ageing and develop innovative UV-resistant materials and technologies, ensuring longer-lasting and more sustainable pavements. The main outcomes of Climate-Pave will include a comprehensive understanding of the ageing processes accelerated by UV radiation, a performance prediction framework for UV-aged bituminous materials, and the development of advanced UV-resistant bitumen blends and technologies. This research will lead to updated protocols for applying these novel materials in road construction, contributing to creating more resilient and sustainable infrastructure. Additionally, the project will provide the Fellow with extensive training in material science, chemistry, and experimental characterization, enhancing his expertise in pavement engineering. Complementary skills training in project management, intellectual property, networking, and teaching will also be provided, promoting collaboration between academia and industry. By strengthening the EU’s leadership in developing climate-resilient infrastructure, Climate-Pave will contribute to reduced maintenance costs, resource conservation, and lower greenhouse gas emissions associated with the pavement. The fellowship will equip the Fellow with interdisciplinary expertise and complementary skills, fostering a successful independent research career in sustainable infrastructure materials, with strong connections to European academic and industrial networks.

Keywords: climate change,pavement durability,ultraviolet radiation,bitumen ageing,sustainable infrastructure,uv scattering materials
Optimal Power Conversion and Energy Storage System for Safe and Reliable Urban Air Mobility (OPENSRUM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: CLOSED

The research proposal addresses the design challenges in the power conversion and the energy storage systems in the electric aircraft used for urban air mobility (UAM). The success of UAM as an alternate transportation system is strongly dependent on designing the overall system to be safe, efficient and reliable. This proposal focuses on improving the power conversion efficiency and designing a smart wireless battery management system (BMS) with accurate battery state-of-charge (SoC) and state-of-health (SoH) estimations. Another desirable aspect in the UAM aircraft is improving the overall payload capacity, which is impacted by the weight of the batteries, interconnection wiring and power conversion efficiency. The proposal aims to improve it by increasing the voltage of the Li-ion battery packs above the current state-of-the-art, which would reduce the current rating and cable weight, while identifying a power converter topology to maximize the overall efficiency. The design optimisation will consider the impacts of higher insulation requirement with higher voltages and overall cost. The power converter topology and the accompanying filters are optimised to reduce electromagnetic interference that can affect the sensitive electronics on the aircraft. The proposal explores data-driven machine-learning based methods to improve the accuracy of the SoC and SoH estimations and reduce the gap between peak error and the root-mean-square error (RMSE). A reduction in the gap between peak and RMSE will provide a reliable upper bound unlike for the case when estimation methods show a lower RMSE but a wide variation in the peak error. The wireless BMS will provide the advantage of easier maintenance and elimination of the conventional wiring weight. This is a timely and innovative project that will help in novel technology development for UAM industry. It will help the applicant gain additional technical and managerial skills that would ensure a successful research career.

Keywords: power conversion and storage,electric aircraft,battery management systems,machine learning algorithm applications
START: Start Talking About Research Today (START)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Ireland
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 346949.44
EU funding (EUR): 346949.44
Participants: 4
Project status: SIGNED

Trinity College Dublin has co-ordinated European Researchers’ Nights every year since 2013. Building on this rich experience of public engagement and researcher development, the START project team will once again coordinate an event across multiple partners and locations in 2024 and 2025. START will spark deeper, more impactful engagement with the public and bring researchers and citizens together in dialogue about the role research and research careers play in our everyday lives. Based on the idea Start Talking About Research Today, the START partners will create a project that will activate various sites around Ireland to highlight the fact that research happens everywhere and takes many forms. START will provide an opportunity for the general public and researchers to engage with each other in new ways. Through a combination of in-person and virtual activities, demonstrations, tours, talks and more, START will promote the idea that research is a living, fundamental part of our society that impacts on and involves everyone. START will work to achieve a number of specific goals: 1. Create new dialogues between researchers and the general public that will lead to a deeper, more profound and sustained engagement with each other; 2. Raise awareness of research and research careers as positive forces in our society; 3. Highlight the role of the European Union in supporting research and discovery. Public engagement and communications workshops will be offered to all MSCA-funded researchers in the first instance, as well as other participants in the events on the Night. A series of activities and showcases will be held across a variety of locations to raise awareness in the months preceding European Researchers’ Night. The START project group has a wealth of talent and experience in public engagement activities, including previous ERN events, and the project team will draw on this expertise to ensure that START 2024/25 is grounded in best practice.

Keywords: public engagement,citizen science