Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Global and local impacts on Atlantic RHODOlith beds: Implications for estimates of blue CARbon ecosystem services (RHODOCAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Rhodolith beds are one of the most extensive benthic ecosystems along the Atlantic coasts and key environments to continental shelf resilience. Besides providing substrate and habitat for numerous other algae and sessile invertebrates, their ability to calcify, their high abundance and biomass, makes rhodoliths major carbonate producers. Recent empirical estimations suggest that the carbonate marine deposits generated by these organisms represent a total potential carbon sink of 0.4 x 109 t C yr-1. Hence, giving the increasing role of marine ecosystems in the storage of blue carbon, rhodolith beds may represent a not yet considered significant carbon store. Regarding carbon sequestration, studies on rhodolith bed community metabolism are scarce and so far only available for two temperate beds that indicate that they can act both as CO2 source and organic carbon sink. As many marine ecosystems, rhodolith beds are currently under threat related to global climate change (GCC), with local impacts due to increasing coastal urbanization, potentially lowering even further their resilience. Thus, by using a physiological approach, this project will provide much needed information on the basic mechanistic understanding of rhodolith metabolism (photosynthesis, calcification), rhodolith responses to global and local stressors, and rhodolith bed community metabolism and carbon storage along a latitudinal gradient. Taken together, this information will allow assessing the importance of rhodolith beds as natural carbon sinks, thus, help ascertain whether these ecosystems meet the requirements to be integrated into climate mitigation policy, and will further allow quantifying the effects of GCC on their carbon sequestration and storage ability. In addition, it will help recognizing potential interactions between global and local stressors, hence, aid in the development of effective local conservation and management strategies.

Keywords: carbon sequestration,calcareous algae,carbon storage,community metabolism,carbon flux,blue carbon
New Strategies For Therapeutic Antibodies – Synthetic bispecific antibodies & Antibody-Drug Conjugates with controlled drug loading. General methods for unexplored ADCs and personalised therapies. (NSFTA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-15
End date: 2022-03-09
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Antibody-Drug Conjugates (ADCs) are revolutionary next-generation therapeutics. The number of ADCs in the clinic is constantly growing with four of them having now reached the market. Despite this great promise, the complex structure of antibodies results in drawbacks for their reliable modification to construct ADCs, thus impairing the full potential of ADCs. One of the major reasons for clinical failure is that it is hard to control the drug to antibody ratio (DAR) to obtain homogeneous structures. Furthermore, current synthetic methods give access to ADCs with a DAR limited to values of 2, 4 and 8, thus lowering the variety of species being tested and possibilities to balance their toxicity. Hence, new synthetic methods giving access to homo- or hetero-functional ADCs with a high control of the DAR would be tremendous progress; being highly impactful to the ADC field and related patient outcomes. Here, we propose innovative methods to functionalise antibodies. Based on a well-established, patented disulfide bond re-bridging method, and orthogonal click ligations, we will finely control antibody modification. This will yield: 1) Mono-functional ADCs with highly controlled DAR, including odd DARs (DAR 1, DAR 3...). This is fundamental to determine the optimal ratio between drug loading and hydrophobicity to obtain the best therapeutic activity. 2) Hetero-functional ADCs with controlled amount and site of functionalisation with different payloads. This includes production of DAR 1+1, DAR 1+1+1…several combinations of payloads are possible, paving the way to promising multi-therapies. 3) Fully synthetic bi-specific antibodies. Our method provides an unprecedented way to obtain bi-specific antibodies in a controlled and adaptable fashion from native antibodies, i.e. without requiring bioengineering. The project addresses unmet needs in the therapeutic antibody field and could bring unprecedented outlooks to this booming sector.

Keywords: antibody drug conjugate adc,antibody modification,drug antibody ratio dar,organic chemistry,thiol re bridging,click chemistry,bispecific antibody,therapeutic application
Launching the First Non-Invasive Brain-Monitoring System for the Early Detection and Management of Encephalopathy In Preterm Babies (BabyLux)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Over the last two decades preterm babies (neonates with less than 37 weeks of gestational period) have rise tremendously reaching 15 million births worldwide in 2014, and the figures are growing. Anyhow, despite we have been successful at maintaining alive premature babies until their live it’s not at risk, we are failing at solving important side-problems. Preterm babies are at high risk of suffering encephalopathies (brain damage) during the artificial gestational stage on the neonatal intensive-care units (NICUs). In fact, about 20% of babies born before 6.5 months gestation experience lasting brain damage. This leads to lifelong disorders such as attention deficit, autism, cerebral paralysis, and hearing or visual impairments. To early detect cerebral damage in a precise manner it’s necessary to provide real time and accurate measures of cerebral oxygen metabolism and blood flow in the brain. This problem remains unsolved since current commercial solutions provide partial measurements or are extremely invasive. BabyLux will be the first device allowing early detect and manage encephalopathies in preterm-babies in a non-invasive and affordable manner by combining two leading photonic techniques. Our product fall within the sub-segment of “monitoring equipment” for NICUs, which is a € 1.200M market growing at a CARG of 6.5%.BabyLux will be sold at a first commercialization stage to pre-clinical markets (research institutions studying brain damage in neonates). We will proceed in such way since to gain credibility among scientific community, easing the entrance to clinical segments. At a second commercialization stage we will approach clinical segments, in particular hospitals with NICUs. This mixed business model will allow HemoPhotonics to achieve a turnover of € 13 M at 5 years after the project compilation. We are requesting a SMEI Phase 1 to further define and corroborate our business assumptions.

Keywords: early detection,brain damage management,preterm babies,neonatal intensive care units,encephalopathies,brain damage,time resolved spectroscopy,diffuse correlation spectroscopy
Artificial Intelligence for Emergency Medical Services: a smart digital assistant for faster and more accurate cardiac arrest recognition during emergency calls (AI4EMS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2020-01-31
Duration (months): 18.0
Total project cost (EUR): 2055976.25
EU funding (EUR): 1439183.0
Participants: 1
Project status: CLOSED

Out-of-Hospital Cardiac Arrest (OHCA) is one of the leading causes of death worldwide. It is a time-critical condition with survival chances decreasing by 10% with every minute of delay from collapse to defibrillation. Currently, Emergency Medical Services (EMS) dispatchers use guidelines to recognise OHCA during emergency calls prior to activating the emergency response system. EMS are struggling as emergency calls have increased in Europe from 100 million calls in 2003 to 320 million in 2016. Thus, assistant decision tools will be necessary to help EMS to faster identify OHCA situations. Our solution, AI4EMS, is the first and only smart digital assistant for EMS dispatchers that supports the triage decision-making by: 1) processing and analysing emergency calls in real-time; 2) recognising OHCA in an evidence-based process from large amounts of historical data (unfeasible to humans); and 3) presenting the most important insights to the EMS dispatcher in a user friendly manner. AI4EMS allows for faster (reducing almost 3 minutes on average) and more accurate (increase from 73.9% human accuracy to 95%) OHCA recognition by leveraging advanced speech analytics and AI. We offer a user-friendly and secure SaaS solution capable of communicating using Natural Language, accessed via a Nvidia TX1-based device. We are directly supporting the eHealth Action Plan 2012-2020 and Digital Single Market (DSM) strategies, by providing a disruptive ICT technology to improve EMS dispatch efficiency and triage accuracy – which will impact the economy and society at large. With the upgrade and commercialisation of AI4EMS we will disrupt the Artificial Intelligence (AI) market for healthcare taking a step further on our goal to become world leaders in EMS artificial intelligence. Forecasted sales will render revenues of €86.7 million in the first five years of commercialization and a total of 127 new jobs will be created by 2024.

Keywords: artificial intelligence,healthcare,machine learning,decision making tool,speech analytics,realtime,smart digital assistant,emergency call dispatcher,control room,cardiac arrest,triage
Spatial and Temporal Analysis of Modern and Past Elephant DivErsity (STAMPEDE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

The proposed project aims to investigate novel ways of bridging the study of evolutionary history of extinct populations with the study of conservation genetics of populations threatened by extinction. I plan to use a multidimensional approach by studying populations across time, space, and scientific fields. Combining the spatio-temporal and cross-disciplinary aspects, I plan to create a unique source of genetic information about African elephants in the past and present. I will do this by generating low-depth genomic data for 500 African elephants from across the current range, which will be used for analyses of present-day genetic diversity and connectivity. In addition, this genomic catalogue will be used to identify the provenance of ancient ivory from the Bajo de la Campana shipwreck that sank near the Iberian coast ~600-500 BCE. This ivory is assumed to have originated in North Africa, and thus, represents a rare opportunity to generate first data of an extinct population of elephants. These were likely the elephants that were used as war elephants during the Punic Wars, but there is an ongoing discussion about which species they belonged to. Using ancient DNA techniques to recover DNA from the shipwreck ivory, I will test if they represent a genetically distinct lineage or show affinity to any of the modern populations. Although the goals of this project are ambitious, all pieces required for its successful realization are already in place, including a network of collaborators providing access to samples, expertise of the supervisor and host institute in conservation projects and bioinformatics, and my expertise in palaeogenomics and conservation genomics. The findings of this project have the potential to yield important scientific achievements and serve as a valuable resource for conservation management, while I will be able to use the acquired experience and training to profile myself as an independent research leader.

Keywords: ivory,shipwreck,african elephant,genomics,ancient dna,palaeogenetics,conservation,population genetics
Automated cooking for tasty and healthy meals in a convenient way (MealHero)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2020-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Over two-thirds of consumer’s report that they enjoy healthy and delicious meals but lack the necessary cooking skills or passion for cooking. Consumers are looking for more convenient food solutions, but existing options are either not healthy or not that convenient. Mealhero has developed and patented the solution to provide healthy, delicious and personals meals cooked at home with zero effort. Our fully personalised meal kits consisting of freshly frozen ingredients are delivered at home; MealHero’s smart steam cooker prepares them with less than 1 minute of work. MealHero uniquely bridges two big consumer wishes: 1) healthy and personalized meals and 2) Busyness is damaging our eating habits: we spend less time cooking and we resort more often to junk-food. There simply is not enough time to prepare a healthy home-cooked meal. We have developed a method for everyone to prepare home-made healthy meals in a simple and convenient way: we deliver freshly frozen ingredients to our customers and all the cooking is done autonomously by our smart steamer. It takes less than one minute of work to prepare a home-made meal. We target people that either who don’t have the time or don’t feel like cooking and who want to live a healthier lifestyle. These people’ needs are unmet by current market offer. For example, meal kits can only deliver the convenience of home-delivery, users still have to spend time cooking. And most people don’t have the time, the cooking skills nor the passion for cooking. Nevertheless, the global meal kit delivery service market was valued at €2.2bn and forecasted to grow at 17% CAGR to reach €8bn by 2025. This confirms that consumers want to eat healthy meals at home. At MealHero, our challenge is to make this option convenient, delicious and affordable. In this project, we will carry the feasibility study: particularly we will validate our business model and solution market fit. We plan to reach €140m revenues by 2027 with 300 FTEs employed.

Keywords: food as a service faas,smart devices
Building planetary systems: linking architectures with formation (BuildingPlanS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2021-11-30
Duration (months): 66.0
Total project cost (EUR): 1945720.96
EU funding (EUR): 1945720.96
Participants: 1
Project status: CLOSED

The last few years have seen an explosion in our knowledge of extra-solar planetary systems. However, most exoplanetary systems look nothing like our own: we see “hot Jupiters” which take just days to orbit their parent stars, planets which meander across entire solar systems on highly eccentric orbits, and even planets orbiting twin, binary suns. These planets formed in relatively homogenous discs of cold dust and gas around young, newly-formed stars, but we do not yet understand how this extraordinarily diverse range of planetary architectures was assembled. BuildingPlanS will establish how the observed architectures of exoplanets link to the physics of their formation. My team will build comprehensive models of the assembly of planetary systems, in order to: 1) understand how systems of giant planets are built. 2) understand the assembly of compact, tightly-packed planetary systems. 3) determine where and when planets form around binary stars. By focusing on the three main types of known planetary systems we will determine how key physical processes operate in a wide variety of different environments, and build up a detailed understanding of how planetary systems form and evolve. Recently I have played a key role in developing a robust theory of how young, gas-rich protoplanetary discs evolve; this project will establish how these new ideas shape the formation and evolution of planetary systems. My team will consider how forming and newly-formed planets interact with their parent discs, in order to understand the architectures of young planetary systems. We will then follow how these young systems evolve to maturity over billions of years, and test our results against both new observations of planet-forming discs and our ever-growing census of exoplanetary systems. The overall aim of BuildingPlanS is to link exoplanet architectures with their formation and establish a global picture of how planetary systems are built.
Palladium catalyzed C(sp3)‒H late-stage diversification of biologically active molecules (LATE-STAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Aliphatic amines are central to the function of many biologically active molecules as evidenced by their prevalence in a large number of pharmaceutical agents. The groups appended to these nitrogen atoms are crucial in determining the physical properties of the amine and are linked to how well it interacts with a biological target. Despite the apparent simplicity of the aliphatic amine motif, the number of general methods that allow their late-stage functionalization directly on the bioactive compound is surprisingly limited, and so the development of directed catalytic methods remains an important challenge. Metal catalysed C–H activation represents a versatile tool for late-stage functionalization. It mostly relies on directing functional groups to functionalize C–H bonds. Recently, Professor Gaunt at the University of Cambridge has uncovered a new C–H activation mode that enables the conversion of hindered amines into β-lactams and aziridines. The first objective of this proposal aims to directly apply the transformations developed by Gaunt, e.g. carbonylation, aziridination and acetoxylation reactions, to a precise class of drugs that contain the secondary amine motif as central function, i.e. β-adrenergic drugs. The use of the oxidative Pd(II)/(IV) catalytic cycle will then allow the development of a novel fluorination. The second objective relies on a new methodological concept, which seeks to merge palladium catalysis with radical chemistry, opening a route to develop novel perfluoroalkylation, amination and methylation reactions via a new Pd (II)/(III)/(IV) catalytic cycle. Finally, the third aim will be to apply all the methods developed to four important anticancer drugs, in collaboration with the new AstraZeneca oncology unit in Cambridge, to prepare novel analogues for biological testing.

Keywords: late stage,c h activation,palladium catalysis,radical chemistry
Bio-pesticide from a strain of Bacillus licheniformis for the control of major pests in different cultures (ASALVO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of Asalvo is to develop all the necessary stages to introduce in the market a bio-pesticide with a proved efficacy in different major pests affecting some of the most important cultures in the world. This bio-pesticide is able to replace the chemical pesticides that currently dominate on the market, providing a bio-product with improved environment and food safety features that avoids also the problems that legal restrictions on the use of chemicals are causing on farmers’ practices. The use of this product will provide farmers with effective and environment-friendly alternatives to cope with pests like aphids and trips even under more restricted environmental regulations. On the other hand, consumers would have healthier and safer food products available. This bio-pesticide has been developed from a strain of Bacillus licheniformis, which is property of Symborg, who has started the patent process. It has a huge pest control capacity, especially for aphids, tryps and whiteflies, being highly innovative due to its multiple action level. Symborg is a technology-based SME, based in Murcia (south of Spain) and founded in 2009. Its main line of business is the design, development, production and marketing of bio-products, based on the functionality of microorganisms for use in highly-intensive and environment-friendly agriculture. This work is interactively done through the articulation of feedback from the marketing activity, direct experience gained in the production processes and the reactivity of his R&D&I department. Symborg is a leader in agricultural biotechnology research, development and innovation. The company is dedicated to the development and commercialization of bio-fertilizers for use in intensive agricultural, while overcoming the challenges of environmental sustainability.

Keywords: bio pesticide,pest management,bacillus licheniformis,aphids,tryps,whiteflies,food safety,environment