Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Epistemic and Dynamic Aspects of Polarization. (EDAPOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Group polarization is a collective phenomenon that typically occurs when an initial tendency of individual group members toward a given direction is enhanced following group discussion. For example, a group of members of the same party will get more convinced of their opinion after an internal debate. The most convincing explanation provided for polarization by social psychologists is based on Persuasive Arguments Theory. The explanation holds that individuals become more convinced of their view when they hear novel and persuasive arguments in favor of their position. Therefore group discussion causes an individual to shift in a given direction to the extent that the discussion exposes that individual to persuasive arguments favoring that direction. However, the exact mechanisms by which this process unfolds are still unclear. The main aim of the EDAPOL project is to unveil the deep structure of the process of information flow and opinion change that generates polarization in a group. To this end, two main tools are combined: argumentation frameworks (AF) – mostly used in artificial intelligence – and logics of information change (LIC) – developed by logicians. The combination of such analytical tools allows to model the knowledge base of an individual (AF), its modification by the successive steps of information exchange (LIC) and, subsequently, to analyze all critical points where polarization can arise in a debate. Understanding polarization on a rigorous basis meets an important societal challenge in the era of social media. Indeed, virtual online discussion witnesses a more pronounced tendency for groups to polarize towards opposite directions than face to face discussions, with a detrimental impact on the associated life of our society. The project will widen Dr. Proietti skillset and provide an important added value towards Dr. Proietti's professional aim of becoming a distinguished researcher in the area of logical research applied to social sciences.

Keywords: epistemic actions,abstract argumentation,group polarization,dynamic epistemic logic,argumentation frameworks
Solving the unsolved Rare Diseases (Solve-RD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Italy,Germany,Spain,Germany,Belgium,France,France,France,Czechia,United States,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Diagnostic characterisation of rare diseases (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2024-03-31
Duration (months): 75.0
Total project cost (EUR): 15361621.25
EU funding (EUR): 15361621.25
Participants: 26
Project status: SIGNED

The main ambitions of the Solve-RD proposal are (i) to solve large numbers of RD, for which a molecular cause is not known yet, by sophisticated combined Omics approaches, and (ii) to improve diagnostics of RD patients through a “genetic knowledge web”. Solve-RD will pursue a clear visionary and integrated “beyond the exome” approach. The entire Solve-RD proposal has been motivated, designed and put together by a core group of four ERNs, but also reaches out to all 24 ERNs. To tackle diseases which are unsolved by applying cutting edge strategies, Solve-RD has thus formed a consortium that comprises (i) leading clinicians, geneticists and translational researchers of these ERNs, (ii) RD research and diagnostic infrastructures, (iii) patient organisations, as well as (iv) leading experts in the field of -omics technologies, bioinformatics and knowledge management. Solve-RD will deliver 7 main implementation steps: (i) Collect Phenotypes, (ii) New phenotype patterns, (iii) Re-analyse exomes / genomes, (iv) Novel molecular strategies, (v) Functional analysis, (iv) Clinical utility and (vii) Towards therapy. For analysis Solve-RD will apply data driven and expert driven approaches. We anticipate to increase diagnostic yield from 19.000 unsolved exomes/genomes by about 3-5%. Cohort specific innovative -omis strategies will be pursued, also addressing cost-effective issues. Analysis of more than 800 patients with highly peculiar (ultra-rare) phenotypes will highly increase the chance to find novel disease genes and novel disease mechanisms. We anticipate to solve more than 2.000 cases. Finding further matching patients will be secured by newly developed matchmaking approaches and by screening using MIPs technology in the more than 20.000 unclassified patients of the ERNs. For the first time in Europe we will also implement a novel brokerage structure connecting clinicians, gene discoverer and basic researcher to quickly verify novel genes and disease mechanisms.

Keywords: european reference networks,solving the unsolved,expert driven and data driven approaches
A Community-based HPV screening implementation in Low-Income countries (CHILI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ethiopia,Germany,Uganda,Spain,Belgium,Belgium,Portugal,Mozambique,Cambodia,United Kingdom
Call: Global Alliance for Chronic Diseases (GACD) - Prevention and/or early diagnosis of cancer (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2999688.75
EU funding (EUR): 2999688.75
Participants: 12
Project status: SIGNED

Cervical cancer is the 4th most common cancer in women worldwide, with up to 85% of the burden in resource-restricted countries. Early detection of precancer has shown to be successful in reducing cancer incidence and mortality. However, a global implementation of this approach is hampered by culture and resource differences between countries. We propose to evaluate the acceptability, feasibility and cost-effectiveness of the ELEVATE cervical cancer screening tool in low-income countries (LIC). The tool is a portable, battery-powered device compatible with self-sampling and comprises an HPV DNA test as well as a proteomic biomarkers detection sensor and will be offered to women in Cambodia, Mozambique and Uganda. This multidisciplinary consortium, led by Ghent University (Belgium), brings together social scientists, health economists and biosensor experts from Europe and the selected countries with industry partners. The approach is three-fold: social science investigations will be conducted to understand current screening practices and to define a tailored strategy, including the ELEVATE tool, embedded in the current health system. Secondly, engineers will validate the self-testing device and will adapt it to reduce the unit price and to enable large-scale manufacturing at an affordable cost. Finally, public health specialists and health economists will evaluate the implementation of the new screening tool to assess its appropriateness and cost-effectiveness. For the latter objective, an intervention will be implemented: in the first arm, the different steps of current cervical cancer screening practices will be optimized (awareness, pre-and post-counseling and referral). In the second arm, the same strategy will be applied in combination with the new point-of-care screening device. Integral part of CHILI is to maximize the use of the new screening tool in low-resource settings in collaboration with national stakeholders and health care providers.

Keywords: cervical cancer,screening,low income countries,community based implementation,self sampling,point of care,hpv dna genotyping,proteomics,cost effectiveness,uptake,acceptability,referral
Remote Rehabilitation Service for Isolated Areas (ROSIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Pre-Commercial Procurement
Countries involved: Ireland,Spain,Spain,Netherlands,Portugal,Denmark
Call: Pre-commercial Procurement for Digital Health and Care Solutions (H2020-SC1-DTH-2020-1, 2020)
Start date: 2021-01-01
End date: 2025-06-30
Duration (months): 54.0
Total project cost (EUR): 5520871.75
EU funding (EUR): 4968784.59
Participants: 12
Project status: SIGNED

Some pathologies like stroke, heart attack, COVID-19 or hip-replacement, may have a dramatic impact in the people health and well-being. Rehabilitation has the potential to reduce, and even reverse these impacts. However, it is a long, intensive in clinical resources, and painful process. Rehabilitation is already insufficiently used, and the ageing population is increasing its demand. Remote areas in some European regions face depopulation. It increases the need of age-related care, and that includes rehabilitation, while resources keep limited and inconveniences of traveling makes the treatment painful and even unfeasible. ROSIA proposes to generate a flexible and scalable value-based model of care, organized around self-management, or self-care. of rehabilitation at home, designed from a tailored integrated care model which optimizes the quality of care and the use of clinical resources. Also a strong implication of the community is needed. This model of care is extensive in its use of technology: (i) disruptive solutions at home, (ii) data driven interventions, and (iii) an open platform for third party solutions that integrates timely and effective communication. To make it feasible ROSIA plans to unlock the current market of disruptive solutions for home rehabilitation by the development of the ROSIA Innovation Ecosystem, to enable clinicians prescribing certified solutions, and facilitating to SMEs and researchers the access to health care system. Patient experience and ethics plays a main role in our methodology for development. ROSIA buyers’ group represents three different European healthcare systems: SALUD, a regional authority from Spain; Coimbra Univ. Hospital from Portugal and National Rehabilitation Hospital from Ireland. Validation will take place in two shires/localities per country. ROSIA includes specialized partners in: integrated care, data management and open platforms,value-based health, patient experience, PCP, coordination and dissemination.

Keywords: telerehabilitation,community interventions,co creation,open platform,remote areas,value based care,self management,patient experience,behavioural change,innovation ecosystem
COVID eXponential Programme (COVID-X)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Ireland,Cyprus,Lithuania,Sweden,Luxembourg,United Kingdom
Call: Medical technologies, Digital tools and Artificial Intelligence (AI) analytics to improve surveillance and care at high Technology Readiness Levels (TRL) (H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT, 2020)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 7911316.96
EU funding (EUR): 7203362.5
Participants: 12
Project status: CLOSED

COVID-X will bridge the collaboration divide between eHealth solution providers -with emphasis on lean startups and small and medium-sized enterprises (SMEs)-, and the healthcare professional system to fight COVID-19. The purpose is to boost an end-to-end agile validation programme of cutting-edge technology in three real-world clinical scenarios, located in hotspots of the pandemic: Italy, Spain and Sweden. The project will fast-track value streams between the two poles under consideration: 1) attract, invest and empower a community of European eHealth SMEs –the beneficiaries of an acceleration program, selected by open calls- that will provide market-ready fast, cost-effective and easily deployable sampling, screening, diagnostic and prognostic systems and/or data-driven services and tools, already certified with -or close to receive- the CE marking (type 1 of the call); 2) actively involve some of the most relevant hospitals of Europe that have the resources, critical mass and ambition to scale-up their capabilities in the COVID-19 response; thanks to the support of an innovative data sandbox, released as an in-house asset of COVID-X, to facilitate access easily, uniformly and securely to various health data sources, and providing data services including Artificial Intelligence (AI)-based decision support systems, data security, visual analytics and intuitive dashboards capabilities. The project will invest dedicated efforts to enforce data privacy and security, ethical compliance and user acceptance. Besides a solid consortium to access world class startups/SMEs, deliver highly valuable technological & business services, provide an innovative data Sandbox with AI capabilities for COVID related services and access 3 piloting sites, COVID-X targets to attract +155 applications and select 31 to undertake through the COVID-X Programme, investing a total of €4.0mil in high impact solution providers.

Keywords: tech startups and smes,piloting,hospitals,technology transfer
Overcoming stellar activity in radial velocity planet searches (GPRV)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1999833.0
EU funding (EUR): 1999833.0
Participants: 1
Project status: SIGNED

Radial velocity (RV) planet searches are a key exoplanet detection method, and one of the only ways to measure a planet's mass. The best RV instruments today reach precisions well below 1 m/s, something which would have seemed impossible 30 years ago. The key factor limiting the sensitivity of RV surveys now is stellar activity. Regions of enhanced magnetic flux on the stellar surface alter the shape of absorption lines in the stellar spectrum, and perturb the measured RVs. I have developed physically motivated but flexible, data-driven methods to disentangle planets from activity in RV data, which are critical to the success of future surveys. I now propose to apply these state-of-the-art techniques to the very large sample of multi-epoch spectra collected by HARPS and HARPS-N, the leading RV spectrographs of the past decade, and then to the forthcoming Terra Hunting Experiment (THE), which will use a copy of HARPS on a dedicated telescope to search for Earth-analogues around nearby stars. The combined HARPS(N) archives are a treasure trove of information on activity-induced perturbations to spectra and RVs, which is currently under-exploited. This project have a transformative effect on our understanding of different types of activity effects, their dependence on stellar properties, and their signatures in the spectra and RVs. It will reveal planets that were missed by previous analyses, particularly around active (young) stars. Finally, it sets out a clear route to the efficient mitigation of activity effects that the THE survey requires to achieve its goals. THE will discover some of the best exoplanet characterisation targets for the next 15-20 years, and my ERC-funded team will be central to its success.
Research Infrastructures Consortium for Horizon 2020 (RICH)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Austria,Germany,Spain,Italy,Switzerland,Belgium,Greece,Poland,France,Czechia,Portugal,Portugal
Call: Network of National Contact Points (H2020-INFRASUPP-2014-1, 2014)
Start date: 2014-12-01
End date: 2019-05-31
Duration (months): 54.0
Total project cost (EUR): 2145266.0
EU funding (EUR): 1996828.5
Participants: 14
Project status: CLOSED

The National Contact Points perform valuable services in guiding and supporting national applicants in preparing proposals for Horizon 2020 funding. We expect that through an enhanced transnational cooperation and networking between National Contact Points for research infrastructures, a higher quality of their consulting services and thus of proposals and projects can be achieved. Therefore, the specific objective of RICH (Research Infrastructures COnsortium for Horizon 2020) is to facilitate trans-national co-operation between NCPs for research infrastructures with a view to identifying and sharing good practices and raising the general standard of support to programme applicants, taking into account the diversity of actors that make up the constituency of the Research Infrastructures Part. By involving 11 formally nominated National Contact Points RICH will be able to will extensively involve the NCPs that have decided to become “associated partner” also thanks to the setting up of a liaison office. Concretely, activities of RICH towards this goal include, amongst others, multi-level trainings and tripling schemes, experts seminars, simposia and wide promotion of Transnational Access and Service (TAS) as well as a wide range of other communication and dissemination tools and platforms. RICH work programme is designed to achieve an improved and professionalised NCP service across Europe, thereby helping simplify access to Horizon 2020 calls, lowering the entry barriers for newcomers, and raising the average quality of proposals submitted.

Keywords: national contact point,research infrastructures,e infrastructures,network
Fascinating World of Researchers in the Age of Technology – Cultural Heritage & the New Generation of Innovators (FAWORIT 2018-2019)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Hungary
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-12-31
Duration (months): 20.0
Total project cost (EUR): 238375.0
EU funding (EUR): 238375.0
Participants: 5
Project status: CLOSED

The main objective of our proposal is to present researchers from several aspects in order to get them closer to the general public and to encourage the youth – with a special focus on girls – to embark on scientific careers. We will apply a mission-oriented, impact-focused approach in our project in which interdisciplinary challenges, innovative solutions, (young) researchers, their work and hobbies will be presented in an interactive, educating and entertaining way to stimulate the interest of citizens towards R&I and to bring it closer to their expectations and concerns. A special attention will be given to the role of R&I in discovery, preservation and demonstration of cultural heritage; the bridges between STEM and cultural heritage will be demonstrated. As the consortium and the cooperating partners represent well the relationship of the knowledge triangle, the involvement of many different actors across various disciplines and sectors will achieve a high impact and make researchers and innovators' work familiar to various age groups. Our main target group is students of age 6-26, but we aim to address all age groups – siblings, parents & grandparents – with attractive programmes. The target audience can thus discover that being a researcher is cool and creative and not only researchers, but young innovators are also amongst us. Our objective is to have at least 30000 visitors on our 24 venues on the two-day event, but a multiple of that number (at least 1000000) will see, hear or read about the NIGHT. Our venues cover the whole country. We expect at least doubling them by organisations joining the NIGHT – the most important science communication event in Hungary – as the result of the awareness raising campaign. We intend to raise awareness of the European engagement in R&I through the participation of H2020 projects with a special focus on MSCAs. In the European Corners and at each venue related programmes of the European Union will be visible.

Keywords: stem,steam,responsible research and innovation,cultural heritage,public recognition,researchers carreer,mission oriented and impact focused approach,societal chall,women in science,edutainment
Evolutionary Consequences of Arrested Genomic Conflict in Asexual Species (No Sex No Conflict)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 1989769.0
EU funding (EUR): 1989769.0
Participants: 1
Project status: SIGNED

Genomic conflicts are major drivers of evolutionary innovation and play an increasingly recognized role in human disease. Intra-genomic conflicts arise because self-promoting elements such as driving centromeres or transposable elements (TEs) can spread in a population without increasing the fitness of their carriers. Inter-genomic conflicts arise when genes have opposite fitness effects in different carriers, as is the case for genes underlying traits with distinct optimal values in males and females. Here I propose to use asexual species as a novel system to studying intra- and inter-genomic conflicts. Because there is no recombination or segregation under asexual reproduction, intra-genomic conflict disappears as the interests of all genetic elements become aligned with those of their host. This allows us to test the predictions that intra-genomic conflict drives the evolution of TE virulence, centromeres, and centromere-binding proteins. Furthermore, because asexual species are comprised of only females, male phenotypes are no longer under selection and sexual conflict over optimal trait values therefore disappears. This proposal leverages the replicated loss of conflicts in independently evolved asexual lineages of Timema stick insects to identify conflict driven aspects of genomic and phenotypic evolution in sexual species. Because Timema have an XX:XO sex determination system, males can be recovered from asexual lineages via X-chromosome losses. This allows for the study of male reproductive traits, sexual dimorphism and sex-biased gene expression in species where selection has been acting solely on females for prolonged time periods, and for the identification of traits and biological processes subject to sexual conflict. By combining phenotypic, experimental and next-generation sequencing approaches, we will generate a cohesive understanding of how intra- and inter-genomic conflict shape phenotype and genome evolution.