Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Accounting for Climate Change in Water and Agriculture management (ACCWA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Spain,Argentina,Spain,Tunisia,France,France,Morocco,Niger
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-03-01
End date: 2024-12-31
Duration (months): 70.0
Total project cost (EUR): 1518000.0
EU funding (EUR): 1518000.0
Participants: 11
Project status: SIGNED

The Mediterranean and Sahel regions are among the most sensitive areas to climate change as demonstrated in many studies (IPCC, 2013). Increased rainfall variability and ET rates will compromise irrigation potential and expansion plans and increased competition and conflict over limited water resources. There are significant knowledge gaps and uncertainties about how much water will be available for a complete growing season, how much should be used for scheduling irrigation efficiently and extracted from these regions. More information regarding water use is necessary to improve agricultural planning and to manage water more efficiently at different scales: farm and catchment/irrigation district level. Over both regions, the temperature increase will cause higher evaporation and transpiration rates, decreasing soil moisture and increasing crop water requirements. The expected impact in rainfed agriculture is a decrease in yield due to heat and water stress and an increase in the likelihood of crop failure in rainfed crops for maize, millet and sorghum (Parkes et al. 2018). Ongoing changes in the socio-economic and environmental background of rainfed farmers combined with the expected population growth make timely and reliable information on rainfed crop yield and its spatial variability essential in decision-support for improving food security and livelihoods. To this end, both understanding of the long term changes (inter-annual variability) and short-term changes (intra-annual variability) are needed. Temperature and precipitation changing patterns will also increase hazards linked to environmental conditions such as droughts, floods or crop pests like locust swarms. ACCWA aims to develop the remote sensing based monitoring tools for agriculture and water and management that help risk guidance in a climate change context.

Keywords: irrigation,water use,food security,drought,yield,management tools,remote sensing
RITHMI: THE SMART MONITOR THAT TAKES CARE OF YOUR HEART (Rithmi)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-10-01
End date: 2019-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Arrhythmia Algorithm S.L. (https://rithmi.com) is a privately held company with the mission to support people to take care of their heart and prevent health problems as the stroke. Our aim is to revolutionize the way Auricular fibrillation is diagnosed through a comfortable, compliant and innovative method. After successfully piloting the prototype version of RITHMI technology, the team can confirm the capability of its breakthrough product to open new markets in Europe with the potential for rapid growth. Rithmi is a pioneer in arrhythmia detection technologies and the leading company in Computational Predictive Care™. By pursuing the present feasibility study, RITHMI’s management team aims to improve its understanding of international market conditions and the associated risks that need to be considered as the company develops a deeper business plan for rolling out, and scaling up RITHMI as a marketable innovative solution. SME Instrument Phase-1 and Phase-2 will be extremely beneficial in helping the company to accelerate development and market penetration of the RITHMI solution in target segments, boosting the company’s growth to 40-50 employees and over € 18,395,412 revenues by 2023.

Keywords: wearable,prevention,stroke,auricular fibrillation
Structural Dynamics of Protein Complexes by Solid-State NMR (complexNMR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-10-31
Duration (months): 66.0
Total project cost (EUR): 1999044.0
EU funding (EUR): 1999044.0
Participants: 1
Project status: CLOSED

Multidrug resistant bacteria that render worthless the current arsenal of antibiotics are a growing global problem. This grave challenge could be tackled by polyketide synthases (PKSs), which are gigantic modular enzymatic assembly lines for natural products. PKSs could be developed for industry to produce chemically difficult to synthesize drugs, but cannot be harnessed until we understand how they work on the molecular level. However, such understanding is missing because we cannot easily investigate large complexes with current structural biology and modeling methods. A key puzzle is how the function of these multicomponent systems emerges from atomic-scale interactions of their parts. Solving this puzzle requires a holistic approach involving measuring and modeling the relevant interacting parts together. Our goal is to develop a multidisciplinary approach rooted in solid and solution state NMR that will make possible studies of complexes from PKSs. The two main challenges for the NMR of PKSs are increasing sensitivity and resolution. Recent innovations from our lab allow application of solid-state to study large complexes in 2–10 nanomole quantities. Building on this approach, with a protein-antibody complex as a test case, we will develop new NMR methods that will enable a study of structure and motions of domains in complexes. We will probe, for the first time, the structural dynamics of PKSs of enacyloxin and gladiolin, which are antibiotics against life-threatening multidrug resistant hospital-acquired Acinetobacter baumannii infections and tuberculosis. These studies will guide rational engineering of the PKSs to enable synthetic biology approaches to produce new antibiotics. If successful, this project will go beyond the state of the art by: enabling studies of unknown proteins in large complexes and providing unique insights into novel mechanisms for controlling biosynthesis in PKSs, turning them into truly programmable synthetic biology devices.

Keywords: solid state nmr,protein complexes,magic angle spinning,protein structure and dynamics
Genomic and epigenomic signatures of climate-mediated selection in cattle (AdaptClim)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Official assessments of climate change impacts in Europe predict substantial economic losses due to the progressive upward trend in average temperatures over the next century, and the decrease in annual accumulated rainfall. Global warming will lead to a decreased forage production and quality, and an increased disease risk, which will significantly change conditions for livestock production. Therefore, increasing climate resilience and enhancing sustainable production for animals in harsh environments are important goals for the livestock industry. Fortunately, a natural experiment already exists where a rapid adaptation to extreme climatic conditions was imposed on a limited number of livestock, Columbus’ arrival in the Americas, which therefore provides a model system to study adaptive selection. Given the accumulating evidence that epigenetic processes may increase the evolutionary potential of organisms to respond to stress and other challenges, the aim of this project is to compare the genomes and methylomes of two tropical Creole bovine breeds, their main Spanish ancestors, and one taurine breed from Africa, to understand rapid adaptation to extreme climatic conditions and identifying biomarkers of resilience. The anticipated outcomes from this project will help in designing management systems to improve productivity, thermal and stress tolerance, and disease resistance in cattle.

Keywords: epigenomics,genomics,rapid adaptation,climate change,biomarkers of resilience,cattle,livestock production
Armoring multifunctional T cells for cancer therapy (ARMOR-T)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-02-29
Duration (months): 72.0
Total project cost (EUR): 1636710.0
EU funding (EUR): 1636710.0
Participants: 1
Project status: SIGNED

Adoptive T cell therapy (ACT) is a powerful approach to treat even advanced cancer diseases where poor prognosis calls for innovative treatments. However ACT is critically limited by insufficient T cell infiltration into the tumor, T cell activation at the tumor site and local T cell suppression. Few advances have been made in the field to tackle these limitations besides increasing T cell activation. My group has focussed on these unaddressed issues but came to realise that tackling these one by one will not be sufficient. I have developed a panel of unpublished chemokine receptors and innovative modular antibody-activated receptors which have the potential to overcome the limitations of ACT against solid tumors. This ground-breaking portfolio places my group in the unique position to address combination of synergistic receptors and enable cellular therapies in previously unsuccessful indications. My project will provide the rationale for provision of an effective cancer treatment. The goal is to develop the next generation of ACT through T cell engineering both by forced expression of migratory and activating receptors and simultaneous deletion of immune suppressive molecules by gene editing. ARMOR-T will provide the basis for further preclinical and clinical development of a pioneering cellular product devoid of the limitations of available products to date. I will prove 1) synergy between migratory and modular activating receptors, 2) feasibility to integrate gene editing into a T cell expansion protocol, 3) synergy between gene editing, migratory and modular receptors and 4) efficacy, safety and mode of action. The main work of the project will be carried out in models of pancreatic cancer. The ARMOR-T platform will subsequently be translated to other cancer entities where response to ACT is likely such as melanoma, breast or colon cancer, providing less toxic and more effective therapies to otherwise untreatable disease.

Keywords: adoptive cellular therapy,t cell engeneering,cancer immunotherapy
Perception of voices that do not exist: Tracking the temporal signatures of auditory hallucinations (ONOFF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Norway
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2021-12-31
Duration (months): 64.0
Total project cost (EUR): 2413371.0
EU funding (EUR): 2413371.0
Participants: 1
Project status: CLOSED

One of the most perplexing phenomena of the human mind is the conviction of perceiving a "voice" in the absence of an external auditory source. This is called an auditory hallucination (AH), and is the most characteristic symptom of the most severe mental disorder, schizophrenia. Understanding the phenomenology, cognitive, and neurobiological underpinnings of AHs will not only provide new insights for explaining schizophrenia, but will also provide new insights into the "complexities of the mind". In my previous research, I have uncovered the neurocognitive markers of the initiation of an AH, focusing on what causes the onset of a hallucinatory episode. The current proposal further narrows the focus, asking a single question; why do AHs spontaneously come-and-go over time, or stated otherwise, why are they not permanently present once initiated? If we believe that the onset of an episode has neurocognitive markers, which all evidence supports, then we must also acknowledge that the offset must have corresponding markers. This question has to my knowledge never been addressed, although it is vital for the understanding of the underlying mechanisms, and for new treatment strategies. I will track the fluctuations of AH episodes in real-time with iPhone app technology, going beyond interview questionnaires. I will track how cognition modulates the onset and offset with an experimental dichotic listening paradigm, going beyond standard tests. I will track what happens in the brain the few seconds before the onset and, in particular the offset of an episode, using component-based fMRI analysis, going beyond "blobology". I will track with MR spectroscopy the interaction of excitatory and inhibitory transmitters that are hypothesized to mediate episode onsets and offsets, respectively, going beyond systems imaging. Thus, I will track AH episodes from the clinical to the receptor level, working vertically through a “levels of explanation” model, from higher to lower levels

Keywords: auditory hallucinations,perception,attention,smartphone app,cognition,neuroimaging,neurochemistry
Global trends in social inequalities in Europe and Latin America and exploring innovative ways to reduce them through life, occupational and educational trajectories research to face uncertainty (INCASI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Spain,Spain,Spain,Italy,Italy,Argentina,Uruguay,Finland,France,United Kingdom,Chile,Brazil
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 2344500.0
EU funding (EUR): 2205000.0
Participants: 20
Project status: CLOSED

The overall aim of this project is to create an International Network for Comparative Analysis of Social Inequalities (INCASI) with 19 universities, 10 from Europe and 9 from Latin America. The purpose is to conduct comparative research in the area of social inequalities. Through this network we hope to foster a space for collective reflection and the development of synergies between network partners that allow us to undertake innovative studies whose outputs have an impact on academic and policy debates on the subject. The project will also contribute to informing the design of public policies to tackle social inequalities. In so doing, we aim to contribute innovative solutions that improve citizens’ living standards, reduce social inequalities and promote social justice. This is in line with Horizon 2020’s objectives. From this perspective, the whole project is structured on the basis of the following four pillars: 1) Substantive background and explanatory models of social inequalities which comprises eight thematic axes integrated in a model of analysis called AMOSIT (Analytical Model of Social Inequalities and Trajectories). 2) Methodology for the analysis of social inequalities 3) Social policies to counteract social inequalities 4) Gender inequalities’ transversal perspective To achieve our objectives we organize the proposal chronologically through five work packages: 1) Compilation: to review the accumulated scientific capital that exists among network’s members. 2) Construction: AMOSIT model. 3) Innovation: to propose a new theoretical and methodological perspective on social inequalities. 4) Projection: to planning the sustainability of the network through two specific lines of action in research and teaching, and to disseminating-communicating project outcomes. 5) Management: Organization and coordination of INCASI network activities.

Keywords: trajectories,uncertainty,gender
The politeness system and the emergence of a Sprachbund (SOUTHWEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

This research aims to fill the gap about the 18th and 19th- Spanish and Portuguese spoken in the Iberian Peninsula, by analysing the emergence and development of their own pragmatic system in forms of address. Both languages underwent deep changes from 1700’s onwards, but these have been hardly researched although some of them affected both sides of the Atlantic. This project attempts to shed light on the arising of a politeness pronouns system that is only attested in the south-western part of the Peninsula and which does not follow the standard or any other system elsewhere in Spain and Portugal. By collecting private correspondence and juridical documents that show real language use, this investigation intends to find why this phenomenon emerged in the south-west, what type of speaker prompted or disfavoured it, what evolution it underwent until establishing itself and what linguistic behaviour it has been characterised by. Likewise, the study of this feature may also underpin the theory about a Sprachbund formed in the south-western Iberian Peninsula between Spanish and Portuguese and how its relation with America prompted common linguistic developments in both the European and American varieties. This study represents pioneering research, since more and more authors are drawing attention to the importance of the 18th and 19th centuries as turning points in the evolution of Spanish and Portuguese, and how these centuries can help understand the current state of both languages and the differences witnessed not only on both sides of the Atlantic, but also within the Iberian Peninsula.
Development of Integrated Web-Based Land Decision Support System Aiming Towards the Implementation of Policies for Agriculture and Environment (LANDSUPPORT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Italy,Spain,Italy,Germany,Hungary,Belgium,Hungary,Hungary,Slovenia,Malaysia,France,Lebanon,United Kingdom
Call: Towards 2030 - policies and decision support tools for an integrated approach to the management of land as a resource (H2020-RUR-2017-2, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 6999771.25
EU funding (EUR): 6999771.0
Participants: 22
Project status: CLOSED

The objective of LANDSUPPORT is the construction of a web-based smart geoSpatial Decision Support System (S-DSS), which shall provide a powerful set of tools devoted to (i) support sustainable agriculture/forestry, (ii) evaluate trade-off between land uses (including spatial planning) and (iii) contribute to implementation, impact and delivery of about 20 European land policies and also selected 2030 UN Sustainable Development Goals including climate change resilience goals and the key SDG 15.3 “achieving a land degradation-neutral world”. This objective is achieved by the integration of already existing databases (interoperability) at different scales with the development of high performance modelling engines simulating agriculture & forestry (e.g.crop growth), land degradation and environmental issues (e.g.fate of pollutants, ecosystem services). All the above, including their validation by remote sensed data will be ensured by a technology at the state of art for the developing environment (i.e.COMPSs), high-performing computing (e.g.GPU) and massive raster data management (e.g.RASDAMAN). LANDSUPPORT will be applied at four geographic scales: EU; 3 Nations (Italy, Hungary, Austria); 2 European Regions in IT and HU; 3 pilot sites in AU, IT, HU; and 2 pilot sites in Tunisia and Malaysia. By doing that, LANDSUPPORT will reconcile grand agriculture/environmental sustainability policy ambitions with operational reality as required by RUR-03-2017 call such as the evaluation of “land use trade-offs” and “incentivizing real actions/behaviour/investments”; all requiring activities at detailed spatial scale. LANDSUPPORT fits with the priorities of this work programme, as LANDSUPPORT S-DSS is (i) scientific and technology innovation as driver for rural development, (ii) a framework for innovation and new business models adapted to the rural context, (iii) support for skills development in rural communities, (iv) a new approach towards policies and governance (subarea 1).

Keywords: land policies implementation,climate change resilience,sustainable agriculture and forestry,multifunctional agriculture,land planning and management,land degradation neutrality,modelling