Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Testing the Large-Scale Limit of Quantum Mechanics (TEQ)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Italy,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 4371473.75
EU funding (EUR): 4371473.75
Participants: 9
Project status: SIGNED

Microscopic systems can be prepared in quantum configurations with no classical counterpart. Such a possibility seems precluded when the 'complexity' of the system grows towards the macroscopic domain: so far we have no evidence of non-classical behavior of the macroscopic world. Why is it so? How is quantumness lost as we abandon the microscopic domain? These questions, which remain to date largely unanswered, address interesting and challenging goals of modern research in physics, and serve the overarching goal of this project. TEQ will establish the large-scale limit of quantum mechanics by pursuing a novel research programme that aims at surpassing the current approach based on matter-wave interferometry. Specifically, the TEQ Consortium will 1) Trap an ad hoc manufactured nanocrystal in a radio-frequency ion trap, cooling it by optical parametric feedback, so as to let it operate in ultra-low noise environments. 2) Determine quantitatively all the major sources of decoherence affecting the nanocrystal, and control them experimentally so as to prepare high-quality quantum states of its motional degrees of freedom. 3) Analyse the light scattered by the nanocrystal to test the quantum predictions for the motion of the particle against those of spontaneous collapse and non-standard decoherence mechanisms, and thus pinpoint/rule-out key quantum-spoiling effects, beyond all the studies performed so far. This roadmap will enable the test of quantum effects for systems whose mass is orders of magnitude larger than that employed in the most successful quantum experiments to date, thus closing the gap with the macroscopic world. Moreover, it will entail significant technological impact: the device that will be built will exhibit exquisite sensitivity to frequency and displacements, thus embodying a significant contribution of explicit technological nature to the design of quantum empowered metrological sensors.

Keywords: quantum decoherence foundations of quantum mechanics quantum technologies
Judicial Conflict Resolution: Examining Hybrids of Non-adversarial Justice (JCR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 1272534.0
EU funding (EUR): 1272534.0
Participants: 1
Project status: CLOSED

In the past few decades, the role of judges has changed dramatically and its nature has remained largely unexplored. To date, most cases settle or reach plea-bargaining, and the greater part of judges’ time is spent on managing cases and encouraging parties to reach consensual solutions. Adjudication based on formal rules is a rare phenomenon which judges mostly avoid. The hypothesis underlying JCR is that the various Conflict Resolution methods which are used outside the courtroom, as alternatives to adjudication, could have a strong and positive influence, both theoretical and practical, on judicial activities inside the courts. Judicial activities may be conceptualised along the lines of generic modes of conflict resolution such as mediation and arbitration. Judicial conflict resolution activity is performed in the shadow of authority and in tension with it, and crosses the boundaries between criminal and civil conflicts. It can be evaluated, studied and improved through criteria which go beyond the prevalent search for efficiency in court administration. Empirically, JCR will study judicial activities in promoting settlements comparatively from a quantitative and qualitative perspective, by using statistical analysis, in-depth interviews, mapping and framing legal resources, court observations and narrative analysis. Theoretically, JCR will develop a conflict resolution jurisprudence, which prioritises consent over coercion as a leading value for the administration of justice. Prescriptively, JCR will promote a participatory endeavour to build training programs for judges that implement the research findings regarding the judicial role. Following such findings, JCR will also consider generating recommendations to change legal rules, codes of ethics, measures of evaluation, and policy framings. JCR will increase accountability and access to justice by introducing coherence into a mainstream activity of processing legal conflicts.

Keywords: judicial conflict resolution,alternative dispute resolution,mediation,therapeutics jurisprudence,non adversarial justice
Low Cost Real-time Multi-Physics Virtual Reality Training System For In-vitro Fertilisation Microinjection Tasks (CellTrainer)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United States,United Kingdom
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-06-01
End date: 2019-11-30
Duration (months): 18.0
Total project cost (EUR): 149995.01
EU funding (EUR): 128029.0
Participants: 2
Project status: CLOSED

The ability to operate on cells is a fundamental capability when developing novel cell based therapies. In this context, the skills needed to manually inspect, prepare and modify cells in-vitro with repeatable micro-nano precision are essential; enabling the creation of new biomedical solutions to fight disease more effectively. Highlighted by the Innovate UK Cell Therapy Catapult, the market opportunity for improved micromanipulation techniques is valued to be >€4.5billion in 2017 and applicable to a wide range of fields from biotechnology, pharmacology to embryology. To realise this opportunity, it is vital to have a well-trained workforce capable of performing repeatable high precision manipulations at a cellular level. However, current training techniques are laborious, vary in quality, and do not take advantage of the inexpensive technologies available today that can improve the expertise of the clinical operators without the need for expensive learning facilities. To address these unmet needs, we present CellTrainer, a virtual reality simulation based training system. Based on the empirical data and biomechanical models gained through our novel micro/nano telehaptic systems that were developed as part of our ERC-AdG grant, in this ERC-PoC project we propose to develop a real-time Virtual Reality (VR) physics engine to simulate different micro/nano training environments and objectively monitor user performance whilst providing clinical learning feedback. In collaboration with spin out company Yantric, UCL Business and identified first customers, we will conduct the necessary commercial activities to translate CellTrainer into the real world. At first, we envisage CellTrainer to be an indispensable tool in reducing the time needed to train up expert clinical users for the in-vitro fertilisation (IVF) market. Lessons learnt here will then be used to access the broader cell based therapy domain and overcoming challenges related workforce productivity.

Keywords: microinjection,virtual reality training,simulation for cellular therapies
Rapid crystallization design platform based on a novel stereo-imaging probe with anti-fouling system (CrystalEyes)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 149963.0
EU funding (EUR): 149963.0
Participants: 1
Project status: CLOSED

The aim of the project is to develop a novel low-cost intelligent crystallization visualization tool that enables the collection of real-time stereo (or combined visible and infrared) images as well as prevents probe fouling by using a specially designed anti-fouling control system. With the additional software interface, with efficient image analysis approaches incorporated in the crystallization process informatics systems, the tool will be the first low-cost, real-time and in situ intelligent imaging tool, with built in crystallization control and design capabilities. With the specially designed anti-fouling system the probe will prevent encrust formation on the probe window, which is a typical problem for all imaging tools currently available on the market. Besides being an efficient and robust monitoring tool, the system will also enable users to readily apply state-of-the-art crystallization design and control approaches developed as part of the ERC CrySys: Crystallisation Systems Engineering – Towards a Next Generation of Intelligent Crystallisation Systems project, for the rapid design of crystallization processes, broadening the potential impact of the control technologies developed in the research.

Keywords: crystallization,image analysis,crystallization monitoring,process analytical technologies
In-depth support for innovation and exploitation in Smart Systems Integration (inSSIght)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Italy,Austria,Germany,Germany,Germany,Germany,Germany,Spain,Germany,Italy,Italy,Germany,Belgium,France,France,United Kingdom
Call: SSI - Smart System Integration (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 1498857.5
EU funding (EUR): 1498857.5
Participants: 18
Project status: CLOSED

The objective of the proposed CSA is to support and complement R&I activities in Smart Systems Integration (SSI) by structuring industrial cooperation and facilitating end-user adoption for the next generations of miniaturised smart objects and systems. Previous CSAs have revealed the immense breadth of SSI in its technology demands, its application sectors, its business ramifications, its provider and user communities, and have commenced the task of joining all these aspects for concerted action. They have also developed support tools, whose proven value can continue to be instrumental in the new CSA. Building on the above and supporting the strategic activities of EPoSS, the role for inSSIght is to deepen and implant this understanding through a cadre of influential partners from SSI-related clusters, research institutes and industries who will define and encourage actions to unlock and exploit innovation opportunities, provide practice-oriented support to the SSI ecosystem, underline the vital position of SSI as a Key Enabling Technology for competitive advantage and future innovation, and give credit to their enabling role as building blocks in sectors with high potential for growth and high return on investment, such as IoT, Industry 4.0, electric mobility, automated driving, smart medical devices etc. Very practically, inSSIght • organises 4 thematic conferences, two of which on MNBS, 7 demonstration sessions, 2 brokerage events, 11 expert and information workshops and 11 webinars • publishes 5 White Papers on Customised Innovation Priorities • leads a marketing campaign for SSI based on a trademark inSSIght addresses all 5 activities required in the scope description of ICT-03-2016b, considering them as inseparable and most efficiently tackled in a single concerted action.

Keywords: smart systems integration,innovation opportunities,visibility,users and procurers needs,stakeholders involvement,strategy development,ecosystem,mnbs,showcasing,training,trademark,strengthen
Bacterial Adhesion Control through Surface TArgeted Regulation (BAC-STAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-12-18
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

Fundamental investigations of bacterial adhesion will create the knowledge base to advance surface engineering approaches. Directed mutagenesis of adhesin genes in several oral pathogens will be used to create a library of knockout strains. Recombinant adhesins will also be over-expressed in E.coli. Assays will be developed to test the interaction of the resulting strains (wild-type, knockouts, over-expressing E.coli clones) with a range of materials, covering the entire spectrum of surface properties with defined roughness, hydrophobicity, porosity, charge and composition. Adhesion kinetics will be monitored in real time, using flow cells to mimic the shear stress and nutrient exchange on implants in vivo. This will complement plate-based fluorescence adhesion assays, western blotting, immunofluorescence microscopy, and ELISAs. Adhesion trends will be tested with targeted surface modifications in pure and mixed culture, creating a feedback-loop for assay improvement with gradually specialised surface functionalization. The ultimate goal is to develop surfaces that promote the adhesion of host tissue, such as human osteoblast cells or gingival cells, whilst still preventing pathogen adhesion. Understanding the fundamental interactions of bacteria with surfaces facilitates the transferability of the results from this project to a variety of further applications (e.g. adhesion of electrogens to microbial fuel cell electrodes; antifouling surfaces etc.). My proposal therefore has the potential to be high impact research, and generates the framework for future interdisciplinary projects.

Keywords: bacteria,adhesin,adhesion assay,surface engineering,antibacterial surface,implants,osseointegration
Pre-transplant Renal Ex vivo Imaging and Multi-omics for Advanced Graft Evaluation (PRE-IMAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 1499961.0
EU funding (EUR): 1499961.0
Participants: 1
Project status: SIGNED

There is a considerable shortage of deceased donor kidneys. Hence, more organs of marginal quality need to be considered for transplantation. Transplant centers are increasingly utilizing ex vivo normothermic machine perfusion to better preserve donor kidneys prior to transplantation. Little is known about molecular pathways that are active while the organ is perfused ex vivo. Also, there is hardly any data on which molecular processes are relevant to assess organ quality during perfusion. I aim to determine the molecular mechanisms of ex vivo kidney perfusion prior to renal transplantation in order to develop breakthrough pre-transplant perfusion-based diagnostic markers that can indicate kidney transplant outcomes. First, a series of normothermic ex vivo porcine kidney perfusions will be conducted with repeated tissue and perfusate sampling. Ex vivo measurements will be contrasted with the contralateral kidney that remains in vivo. Genomics, transcriptomics, proteomics and metabolomics, as well as ex and in vivo magnetic resonance imaging followed by radiomics will be employed. Distinct molecular pathways will be identified which characterize an ex vivo perfused kidney, compared to the organ’s behaviour in vivo. Second, the discovered molecular pathways will be validated for human donor kidneys by performing ex vivo perfusions of discarded human organs followed by the same multi-omics approach. Finally, a prospective clinical study will be conducted with human kidneys that are perfused ex vivo prior to transplantation. With artificial intelligence analysis, tissue and perfusate multi-omics measurements and standard clinical variables will be associated with transplant results, to create advanced prediction models for post-transplant outcome. The high gain of my project will be a better understanding of molecular mechanisms during ex vivo kidney perfusion and advanced, personalized pre-transplant prediction models for post-transplant outcome.

Keywords: kidney transplantation,ex vivo machine perfusion,multi omics analysis,prediction models,artificial intelligence
Fast-tracking ROOTStock breeding in olive (FROOTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-05-01
End date: 2023-08-20
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Adaptation to environmental conditions is key to maximise crop productivity under limited water and other stresses related to climate impacts. Combining stress resistance with desired agronomic characteristics through regular plant breeding in fruit trees such as olive requires a huge amount of time and resources and might not be feasible by just using the current available genetic pool. However, the use of rootstocks could overcome some of these stresses that are challenging tree crops worldwide and allow to unlock the genetic potential of wild relatives of olive. The objective of FROlive is to speed up the rootstock breeding process in olive trees by developing accurate, fast phenotyping and grafting methodologies for the early selection of new olive rootstocks, in first instance for drought resistance. This will be done by using techniques that are known to the applicant due to his background in plant breeding and disease resistance screening and analysis techniques, in collaboration with the hosting group, which has a strong track record in the study of olive germplasm resources, genetics and breeding, as well as proven ability to train students and scientists. The approach and techniques used in FROlive will allow a faster development of rootstocks resilient to new challenging environments and pests, therefore reducing the environmental impact and future proofing our olive orchards. The training will allow the applicant to be trained as a fruit tree breeder, increasing the capability in this research area. The project presents a multidisciplinary approach as it brings together plant propagation, germplasm resources, genetics and statistics. It also represents a collaboration of five different partners, the University of Córdoba, the Swedish University of Agricultural Sciences, the University of Málaga, the Institute for Sustainable Agriculture and the company Plantas Continental, S.A., opening the possibility for further collaboration between the institutions.

Keywords: drought resistance,olea europaea,rootstock scion interaction,grafting
From Planet-Forming Disks to Giant Planets (Origins)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-12-31
Duration (months): 63.0
Total project cost (EUR): 2474252.5
EU funding (EUR): 2474252.0
Participants: 1
Project status: SIGNED

Planet-forming disks around young stars display a large variety of spatial structures indicating pattern formation by gas-dust dynamics and planet-disk interactions. The diversity of planetary properties point to different physical and chemical conditions in their parental disks and a range of formation pathways. Currently, there is no unifying approach which connects disk physics and chemistry with exoplanet properties. The development of such a link remains a considerable challenge as long as fundamental disk properties are uncertain. The objective of this project is to close the gap between the conditions in planet-forming disks and the properties of giant planets and their atmospheres. We will constrain fundamental disk properties - mass, turbulent state, and molecular content - by dedicated infrared and (sub)millimetre observations combined with comprehensive modeling efforts and experimental studies of ice-grain surface chemistry. The second very demanding project goal is to discover young giant planets in their birth environments and to characterize their properties, applying innovative techniques to analyze the results of approved imaging surveys with AO instruments at the VLT/LBT. These data will be supplemented by ALMA observations tracing gas kinematic signatures induced by embedded planets. The results of these studies will lead to major progress in understanding the timescale for planet formation and will reveal the nature of planet-disk interactions. The most challenging objective of the project is to build a connection between disk properties and the atmospheres of giant planets. Planet formation and evolution models will be coupled with a description of the chemical and accretion history to predict planetary elemental abundances, setting the scene for the thermal and chemical structure of giant planet atmospheres. Synthetic spectra will be provided using state-of-the art atmospheric codes and will be compared to observed planet spectra.

Keywords: planet forming disks,formation of giant planets,planetary properties