Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Neuropeptidergic modulation of synaptic circuits in fear and anxiety (PeptidesAndFear)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 1499725.0
EU funding (EUR): 1499725.0
Participants: 1
Project status: SIGNED

Fear and anxiety are Fear and anxiety are essential for survival. Adequate reactions to anticipated and perceived threats strongly depend on the current state, context and previous experience. What are the neurobiological mechanisms that underlie these adaptive behaviors? While synaptic circuits are the backbone to process threat signals and transform them into behavioral responses, increasing evidence suggests that neuropeptides tune these synaptic circuits in a state- and context-dependent manner, thus allowing for temporal control of excitability and plasticity. Neuropeptide receptors are abundantly expressed in neuronal circuits that regulate fear and anxiety. In fact, recent evidence suggests that most neurons synthesize multiple neuropeptides and, in turn, are regulated by multiple neuropeptide receptors that are expressed in highly cell type-specific patterns. Indeed, genetic alterations in humans as well as pharmacological and genetic experiments in mice indicate important roles for multiple neuropeptides in regulating fear and anxiety and, if dysfunctional, increasing the risk for multiple neuropsychiatric disorders. However, due to the lack of specificity of existing tools, the circuit mechanisms underlying these effects are largely unknown. In this proposal I aim to reveal cell type-specific neuropeptidergic signaling mechanisms for context-dependent regulation of cortical circuit activity, cellular excitability and synaptic plasticity. I will use cutting-edge in vivo imaging and circuit manipulation tools combined with region- and cell type-specific CRISPR/Cas9-mediated genetic ablation to reveal how these neuropeptidergic signaling mechanisms regulate behavioral responses in the context of fear and anxiety. This multidisciplinary approach will allow me to gain unprecedented mechanistic insights into how neuropeptides drive adaptive circuit computations and how their dysfunction underlies maladaptive behavioral and emotional responses to external cues.

Keywords: neuropeptides,prefrontal cortex,crispr cas9,g protein signaling,fear and anxiety,gabaergic neurons,ion channels,synapses,neuronal activity,plasticity
NExt-generation MOdels for advanced battery electronics (NEMO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Belgium,Austria,Italy,Germany,Switzerland
Call: Physics and data-based battery management for optimised battery utilisation (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-05-01
End date: 2026-10-31
Duration (months): 42.0
Total project cost (EUR): 4903103.75
EU funding (EUR): 4903103.75
Participants: 8
Project status: SIGNED

NEMO project aims at advancing the state of the art of battery management systems (BMS) by engaging advanced physics-based and data-driven battery models and state estimation techniques. Towards achieving this goal, the consortium tends to provide efficient software and hardware to handle, host, process, and execute these approaches within high-end local processors and cloud computing. NEMO benefits from a wide range of sensor information acquired at high frequencies in addition to dedicated electrochemical impedance spectroscopy (EIS) sensors which allow for the identification of ongoing electrochemical reactions inside each individual battery cell. Capable hardware for storing and processing such measurements will be provided by the tier1 members of this industry onboard the consortium. The availability of such diverse physical information on batteries onboard makes room for developing cutting-edge performance, lifetime, and safety battery models and state estimators within NEMO, and validating them on two different BMS configurations. Physics-based performance model parameters continuously get updated as the battery ages, so that performance and safety state indicators maintain the least possible error. The data-driven approaches exploit mathematical algorithms to be trained upon the large datasets made available from historical or laboratory-generated battery information. Combinations of coupled physics-based and data-driven approaches are also foreseen to be implemented within NEMO as another innovation of the project to propose next-generation BMS. Solutions offered by NEMO considerably extend battery life and make the battery system safer within long-term operation since every individual cell is monitored, controlled, and studied. NEMO’s ambitious solutions for stationary and automotive use cases are expected to be validated by industrial partners and to take a considerable share of the market in later years.
European Core Technologies for Next Generation Communication-Computing Hardware (COREnext)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Sweden,France,Belgium,Netherlands,Italy,Greece,Austria,Switzerland
Call: European Enabling technologies for Beyond 5G/6G RAN disaggregated architectures (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 12988081.25
EU funding (EUR): 12988081.0
Participants: 24
Project status: SIGNED

The COREnext project aims to build a computing architecture and digital components for sustainable and trustworthy B5G and 6G processing. This architecture must support an open, multi-vendor and multi-tenant disaggregated RAN by employing virtualization technology. A step forward in digital component design must be made to address the compute throughput and energy-efficiency requirements. This is addressed by the development of powerful and efficient heterogeneous accelerators, purpose-built for RAN computation and signal processing, as well as ultra-high-speed and low-power interconnects to support disaggregation of compute resources. A cornerstone of the project is trustworthiness. The pervasiveness of B5G and 6G use cases requires deeply embedded hardware trust anchors to fulfil the vision of secure disaggregated compute systems. To realize these goals, the project brings together major telecommunications and microelectronics players as well as academic research partners. A strategic roadmap will offer a transparent path towards future exploitation of the generated research results, fostering a continuing European strategy for the emergence of European digital capabilities in this communication-computing domain.

Keywords: computing architecture,digital components,trustworthiness,disaggregated architecture,virtualization,heterogeneous accelerators,high speed interconnects,analogue fingerprinting
Rebuilding Joint Surface to Prevent Pain and Immobility (RePace)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-01-01
End date: 2024-06-30
Duration (months): 30.0
Total project cost (EUR): 3570000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: CLOSED

A healthy layer of articular cartilage at the end of bones in joints is essential for painless movement. When cartilage is damaged, it has minimal innate regenerative properties and there is no effective medical cure. Cartilage damage seriously reduce quality of life and has severe economic impact since loss of cartilage leads to osteoarthritis (OA) that causes hundreds of billions of Euros healthcare and related costs annually. Many attempts have been made to restore joint surface cartilage, but the tissue has shown to be extremely difficult to rebuild. Askel has developed a unique way to rebuild joint surfaces for pain-free movement. COPLA® is a biodegradable implant that creates a weight-adaptive microenvironment in the damaged site enabling quick rehabilitation and cartilage regeneration to prevent OA. COPLA® will become the Gold Standard for early cartilage repair with rapid recovery and long-term results, ensuring pain-free movement, high quality of life and prevention of OA.

Keywords: cartilage regeneration,tissue engineering,cell biology
Diaspora Claims for Representation in Europe (DIASPOREP-EU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

In a time of democracies’ crisis of legitimacy, new faces of political representation are renewing our understanding of democratic representation. Among them, Diaspora organisations (DOs) have emerged as key transnational actors engaging with public and private institutions, governments, and civil societies at all levels. This research examines the contemporary building of diaspora claims for representation at the European level. It aims at shedding light on the framing process of the demand for non-elective political representation expressed by umbrella organisations, networks and platforms of European citizens and residents with migrant ancestries and diasporic ties, within the EU institutional bodies and multi-level and multi-actors arenas led by the EU. To address it, my research explores three closely connected research objectives: (1) The diverse faces of diaspora civil society representative organisations in Europe today (2) The framing process of the diaspora organisations representative claims (3) The legitimizing of non-elective representation of diasporas in Europe. Anchored in political sociology, my research framework is cross-disciplinary and brings together diaspora studies and democratic representation studies. It builds on a mixed-methods design with a strong qualitative leaning, and is partly co-designed and disseminated in collaboration with the European instrument EUDiF. My research addresses a topical issue and aims at offering both empirical and theoretical contributions to academia (7 communications, 3 articles, 1 special issue), and to practitioners, activists and policy-makers (Web publications, conference, non-academic communications, fact sheet, policy brief, outreach meeting). This 2 year project will be supervised by Pr Jean-Michel Lafleur, hosted at the CEDEM research unit, ULiège, and builds on two strong research collaborations with the IMISCOE research network and the EU Diaspora Facility (EUDiF).

Keywords: diaspora organizations,non elective political representation
Safe and sustainable LOW-Carbon fuels for heavy-duty, aviation, and maritime sectors – Hop On (4LowC)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Norway,Greece
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 34.0
Total project cost (EUR): 589375.0
EU funding (EUR): 589375.0
Participants: 2
Project status: CLOSED

LowC is characterizing and quantifying air pollutant emissions from low- or zero-carbon fuels in heavy-duty, aviation, and maritime sectors to ensure that solutions to reduce CO2 emissions are safe and sustainable. The proposed Hop-On Facility project called 4LowC with the inclusion of the widening partner FORTH, will extend the objectives of LowC and assist it in achieving its goal by contributing new measurement and modeling capabilities. Objectives of 4LowC: 1. Improve the emission characterisation in LowC by contributing state-of-the-art instruments and techniques for the measurement of volatility distribution of the emissions, ultrafine particles, and chemical composition of the emitted particles. 2. Provide complete volatility distributions of the emitted organic material (gas and particle phase). 3. Use these volatility-resolved emissions in the state-of-the-art chemical transport model PMCAMx-UF to simulate the effects of different emissions scenarios on ultrafine particle levels but also PM2.5 mass concentrations over Europe. 4. Improve access of FORTH to networks of excellence through cutting-edge research activities, and good management and dissemination/exploitation practices. FORTH will bring high-level expertise and cutting-edge instruments and chemical transport models. The complete volatility distribution of the emitted organic pollutants (from extremely low volatility to semi- and intermediate volatility compounds) which is key to understanding their environmental impacts, will be determined combining thermodenuding, GC-MS, PTR-MS, isothermal dilution, and aerosol dynamics models. This will make the LowC results suitable for direct inclusion in state-of-the-art chemical transport models based on the Volatility Basis Set. FORTH will incorporate these results in their chemical transport model PMCAMx-UF to investigate the effects of the various technologies on ultrafine particle concentrations but also on fine particle mass (PM2.5) over Europe.

Keywords: air pollution climate change climate drivers aerosol chemistry particulate matter ultrafine particles chemical transport modeling public and environmental health
Making the Ariane Rocket: Negotiating relations between European integration and the future of Europe in space (FutureSpace)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1476276.25
EU funding (EUR): 1476276.0
Participants: 1
Project status: SIGNED

When we think about practices of European integration, we rarely think about how they may extend to outer space. Yet, a new global space race is in full swing, in which commercial and government actors worldwide are putting forward bold visions of human futures in outer space. Europe is at the cusp of deciding which role to play in this new space age. Do we witness the emergence of shared European visions for outer space, and how would these build on and inform current European integration practices? These questions are at the center of FUTURESPACE. They will be investigated using the joint European rocket Ariane as a case study. While Ariane was heralded as a symbol of European integration since its first launch in 1979, the rise of commercial companies like SpaceX has spurred profound debates about the future of the European Ariane program. My project will be unique in its attempt to expand questions of European integration to outer space by asking: Which kind of space futures are projected onto and realized through Ariane, and how do these futures relate to ideals and tensions of European integration? By exploring the intricate relations between large-scale technological projects, practices of European integration, and envisioned space futures, my project will provide empirically and theoretically rich insights into how the future of European integration in space is imagined and enacted in the global space race. Methodologically, FUTURESPACE conducts an interdisciplinary ethnography that links social science and engineering to better understand the material and imaginative aspects of this unique space infrastructure. With the increasing relevance of outer space for societies on Earth, such a project is much needed. FUTURESPACE will offer highly relevant and timely insights into how future visions of space shape forms of European collaboration in the present and how, conversely, geopolitical relations on Earth shape how, and by whom these futures are imagined.

Keywords: outer space european integration sociotechnical imaginaries new space,infrastructures,technopolitics
Genomic observation and perturbation: genetic modifiers to untangle disease mechanisms of RFC1 repeat expansion (GEMREX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Biallelic repeat expansion in RFC1, an essential gene involved in DNA replication and repair, are a leading cause of ataxia and neuropathy in the adult population. Nonetheless, the exact mechanism linking RFC1 repeat expansion and neurodegeneration remains elusive. The prevailing hypothesis is that the repeat may lead to a partial loss of function of RFC1, by affecting expression of neuron specific RFC1 isoforms or by impairing its fine regulation in terminally differentiated neurons, including sensory neurons and Purkinje cells. The objective of proposal is to leverage state-of the-art genomic medicine methods, including the observation of the naturally occurring genetic variation and controlled genome perturbation, to unravel disease relevant pathways. We will perform a genome-wide association (GWA) analysis complemented by long read sequencing to identify genetic modifiers of onset, phenotype and progression of RFC1 disease. We will take advantage of the Crispri technology in genetically engineered iSensoryNeurons to further investigate the effect of GWA loci and to identify additional factors which can modulate RFC1 expression and ameliorate or exacerbate the molecular phenotype. As modifiers are likely to act at cell specific and dynamic level, genetic data will be paralleled by single-cell approaches in post mortem cerebellum and dorsal root ganglia, as well as IPSC sensory neurons and cerebellar organoids. Finally, given a high carrier frequency of RFC1 expansion nearing one out of ten people, we will try to understand whether the repeat itself can act as a modifier of common health and disease traits at population level. The results will hopefully lead to a better understanding of disease causing mechanisms and identify potentially druggable targets. The study output may also have broader implications considering the central role of DNA repair in neuronal functioning and ageing.

Keywords: repeat expansion diseases,ataxia,neuropathy,genetic modifiers,gwas,crispri screening,long read sequencing
Smart 4D biodegradable metallic shape-shifting implants for dynamic tissue restoration (BIOMET4D)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Belgium,Germany,Ireland,Poland
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-07-01
End date: 2026-12-31
Duration (months): 54.0
Total project cost (EUR): 4039541.25
EU funding (EUR): 4039541.25
Participants: 9
Project status: SIGNED

Reconstructive surgeries frequently require multiple, often complex, procedures at high social and economic costs. A shape-morphing implant that can be implanted using less invasive procedures and that then undergoes predesigned shape changes, leading to tissue expansion and allowing for complete degradation coupled with tissue regeneration, is a radically new treatment concept. BIOMET4D aims to create a new generation of shape-shifting and load-bearing implants for dynamic tissue restoration and to introduce a revolutionary paradigm in how actuators can be implemented in biomedicine. Science-towards-technology breakthroughs will be demonstrated with new shape-morphing metamaterials, 4D smart metallic actuators, advanced multi-domain optimization tools, and finally proof-of-concept for two potential clinical applications. Technologically, this vision also goes beyond existing paradigms because of the step-by-step actuation mechanisms, enabled through the additive manufacturing of multi-material degradable metallic structures, that are targeted for an order of magnitude improvement compared to the state-of-the-art. A futuristic long-term vision of this breakthrough technology is to dynamically regenerate entire tissues, such as a nose or an ear, and proof-of-concept will be demonstrated for craniosynostosis treatment and skin expansion. This long-term vision can only be achieved through an interdisciplinary approach and will likely have high social and economic impact as well as provide a new line of research for applications of smart metamaterials in medicine and engineering.

Keywords: metamorphic lattices,4d printing,biodegradable metals,craniosynostosis,skin expansion,computational modeling,multi domain optimization,actuators,powder bed laser fusion,animal models