Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Border Change and Local Development in Europe and Beyond (BORDERS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499956.0
EU funding (EUR): 1499956.0
Participants: 1
Project status: SIGNED

Border changes through secession, unification, and territorial transfers have reshaped almost all states in Europe since 1815 and revisionism continues to threaten states worldwide until today. While the causes of border change are well-studied, its consequences for local development have been much less scrutinized. BORDERS therefore analyzes the mechanisms through which border change has affected local development in Europe and beyond over the past two centuries using new theory, data, and methods. BORDERS’ central contributions are delivered by four work packages (WP). WP1 develops a theory of the impact of border change on socio-economic development through changes in local ethnic demography, economic market exchange, state capacity, and ethnic politics. WP2 produces unparalleled longitudinal data on local development across Europe since the 18th century by using machine learning to measure village-level development from historical survey maps. Additional data from historical administrative and geographic sources will be collected to capture the relevant causal mechanisms. WP3 empirically examines the theory and mechanisms developed in WP1 across the more than 200 border changes in post-1815 Europe using methods for causal inference in geographically disaggregated panel data. WP4 tests the applicability of the theory across a global sample of border changes since 1945, examines contextual factors that explain variation over time and across cases, and investigates divergences with effects observed in historical Europe. In times of renewed border contestation, BORDERS contributes new theory and robust evidence on the local effects of border change in Europe and beyond. The project enriches debates on long-run development and provides data on historical development in Europe of unprecedented detail. Innovations in map digitization and methods to gauge the generalizability of causally identified micro-level effects contribute to the social sciences more generally.

Keywords: border change,local development,socio economic development,europe,historical political economy,infrastructure,ethnic geography,state formation,state building,machine learning,gis,causal inference
The organization of the archaeal cell (ARCHCELLORG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2498000.0
EU funding (EUR): 2498000.0
Participants: 1
Project status: SIGNED

Archaea are microbes that form one of the three domains of life. While sharing similarities with both Bacteria and Eukarya, archaea possess unique features such as atypical lipid membranes, the archaellum motility apparatus, and exclusive metabolic pathways like methanogenesis. Studies over the last decade have substantially expanded the archaeal tree of life, revealing the tremendous diversity, widespread distribution and vital ecological roles mediated by these organisms, as well as their crucial evolutionary placement as close relatives of eukaryotes. Despite these major advances regarding archaea diversity, ecology and evolution, our knowledge of archaeal cell biology remains limited, particularly due to the scarcity of model systems and suitable genetic and imaging tools. In ARCHCELLORG, we propose to explore recent methodological advances, including the ability to perform live cell imaging on the model archaeum Haloferax volcanii, combined with genetics, physiology, biochemistry and structural approaches, to unravel the mechanisms governing three fundamental aspects of archaea cellular organization: cell division, polarity, and shape regulation. In Aim 1, we will elucidate the molecular composition of the archaeal division machinery and the mechanisms involved in its organization and placement at the division plane. In Aim 2, we will identify the main regulators of cell polarity and characterize their modes of action. In Aim 3, we will investigate regulators of shape transition and define the mechanisms by which they coordinate shape changes and motility. Elucidating these processes will not only contribute to further our understanding of archaeal cell organization but will likely also provide valuable insights into the evolution of cellular life on Earth, including the processes that led to the emergence of eukaryotes.

Keywords: archaea,molecular microbiology,cell division,ftsz,septum,cell polarity,cell morphology,cell shape,haloferax,euryachaea
NEXT-GEN URBAN FREIGHT LOGISTICS FOR NET ZERO EMISSIONS THROUGH INNOVATIVE SOLUTIONS (NEXTLOGIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Innovation actions
Countries involved: Luxembourg,France,Czechia,Italy,Germany,Slovakia,Poland,Netherlands,Spain,Denmark,Ireland,Belgium,Switzerland
Call: Rethinking urban spaces towards climate neutrality (HORIZON-MISS-2024-CIT-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 16096814.08
EU funding (EUR): 14837694.49
Participants: 35
Project status: SIGNED

NEXTLOGIC is a collaborative, digitally empowered platform that drives the co-design and co-creNEXTLOGIC is a collaborative, digitally empowered platform that drives the co-design and co-creation of transport, mobility, and logistics solutions for cities and their stakeholders, including citizens, businesses, and authorities. It leverages an advanced Digital Twin (DT) enhanced with eXtended Reality (XR) and gamification to simulate, assess, and present urban scenarios in an immersive, data-driven environment, fostering informed decision-making. By integrating real-time data from Floating Car Data, IoT sensors, and historical datasets, NEXTLOGIC will dynamically models traffic, logistics, and urban space usage. It will optimize urban planning through geospatial analytics and adaptive space management, transforming logistics with smart loading zones and mobile microhubs with electric cargo bikes, enhancing last-mile delivery efficiency through dynamic and multi-functional urban space. NEXTLOGIC will enhance accessibility and optimize city-wide logistics by integrating multimodal transport hubs, real-time data, and urban surroundings, reimagining cities as a hub-and-spoke system that connects services within a 15-minute radius. Additionally, it will incentive mechanisms and reward schemes aiming at better urban public space connectivity and accessibility, use of the infrastructure and the vehicles, reduced need and better management of public space, and creation of smart energy solutions that will close the gap between where the (green) energy is produced and where and when it is consumed. NEXTLOGIC will deploy pilots in eight European cities, bringing together 34 multidisciplinary partners from 13 countries to create more connected, accessible, and efficient urban environments. By optimizing infrastructure, reducing public space demand, and enabling sustainable, data-driven mobility solutions, NEXTLOGIC aims to transform urban logistics and mobility across Europe.

Keywords: urban logistics
Novel AI-Powered Magnetic Navigation Platform for Spine Surgery…and beyond (Neevut.AI System)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Spinal surgeries, with over 7 million performed globally each year, demand precise instrument and implant placement to prevent serious complications. Traditional approaches, relying heavily on surgeons' anatomical expertise and fluoroscopy, risk misplacement and expose patients and staff to high levels of radiation. Recent innovations in computer-assisted surgery (CAS) and navigation systems have improved precision but come with significant drawbacks, including high costs, line-of-sight limitations, and restricted tracking ranges. These systems also often require compatibility with specific implant brands, reducing their flexibility. This project presents Epidutech's groundbreaking magnetic camera technology, designed to overcome these limitations. Our system employs advanced magnetic tracking combined with deep learning algorithms, offering several key advantages over traditional optical systems. Unlike optical tracking, our magnetic approach does not require a direct line-of-sight, allowing for continuous tracking even with obstructions or patient movement. This technology extends tracking capabilities deep into the patient's body, enhancing accuracy and reducing errors associated with tool deformations. Furthermore, Epidutech's solution is highly cost-effective, eliminating the need for substantial capital investment and ongoing service costs typically associated with traditional CAS systems. This not only makes the technology accessible but also reduces overall procedural costs. With these advancements, our system has the potential to reduce surgical complications by up to 30%, thereby enhancing both safety and efficiency in spinal surgeries.

Keywords: spinal surgery magnetic tracking computer assisted surgery cas navigation systems fluoroscopy deep learning algorithms surgical precision radiation reduction patient safety cost effectivenes
AlzoSure® family tests: towards accurate, non invasive and cost-effective prognosis of cognitive decline to dementia (AlzoSure)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

At Diadem we are determined to solve one of the biggest problems in dementia drug development and patient care: early, accurate, predictive, fast, non-invasive and cost-effective diagnosis of dementia. We are developing simple and low-cost non-invasive blood tests that use a unique biomarker to provide early prediction of the potential to decline into dementia due to AD, as well as being able to differentiate between different types of dementia. Commercialisation of our tests not only represent a highly attractive business opportunity but aalso hold the potential to revolutionise a) the patient journey to a dementia diagnosis b) the development, approval, and use of disease modifying treatments (DMTs) designed to slow the decline of individuals by identifying, early on, who are the patients who should be prioritized to receive treatment.

Keywords: dementia diagnosis alzheimer s disease
A novel click chemistry-based, universal radiolabelling platform revolutionizing the generation of theranostic radiopharmaceuticals (TETRAKIT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 3512429.0
EU funding (EUR): 2458700.3
Participants: 1
Project status: SIGNED

TetraKit Technologies (TT) is developing the TetraKit Platform, a universal radiolabelling platform that enables the synthesis of novel therapeutic and diagnostic (theranostic) radiopharmaceuticals (RPs). By overcoming the limitations of currently available radiochemistry solutions, TT will address the unmet need for an innovative approach that makes radiolabeling, specifically with radiohalogens, simple, rapid, effective and scalable. Based on an ultrafast next generation tetrazine ligation and linker technology, the TetraKit Platform allows labelling of any biomolecule (target vector) with any radiohalogen or radiometal, according to a versatile ‘plug-and-play’ principle. As such, TT will facilitate unleashing the full potential of novel theranostic RPs to serve the need of millions of cancer patients worldwide. To validate the TetraKit Platform, TT seeks EIC Accelerator blended financing to advance the clinical development of the lead asset emerging from the platform, 131I-DualFAPi, an iodine-131-labelled therapeutic RP that targets the fibroblast activation protein (FAP) – THE ‘next billion-dollars theranostics target’. Initially to be developed for the treatment of metastasized Triple Negative Breast Cancer (TNBC), an aggressive type of cancer with poor survival chances, TT’s lead asset will be the first radiohalogenated FAP-targeting therapeutic RP in clinical development, made possible by the TetraKit Platform. Completion of a Phase 1/2 program in TNBC patients will present a significant value inflection point for TT, which is anticipated to result in a strategic partnership for the final development and commercialization steps. Successful development of 131I-DualFAPi will be an essential milestone that will allow TT to fully exploit the TetraKit Platform, bringing immense commercial and societal value.

Keywords: radioligand therapy,radiohalogenation,theranostics,radiolabelling platform,radiopharmaceuticals,cancer,precision oncology
The Macroeconomics of Managers (MACROMGR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Austria,Hungary
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1782794.0
EU funding (EUR): 1782794.0
Participants: 3
Project status: SIGNED

There are enormous differences in productivity both across countries and across firms within the same country. Not only is the average firm less productive in poor countries, the allocation of resources across firms is also less efficient. Good management is understood as one of the key determinants of firm performance. Why don't management best practices spread from good firms to bad ones and from rich countries to poor ones? In order to explain management practices and productivity at the macroeconomic level, we need to understand where good managers come from and how they are allocated across firms. I propose a new research agenda of the macroeconomics of managers. I will build three quantifiable theories to describe the market for manager skills and estimate them in new longitudinal data on the universe of firms and top managers in Germany (1991-2021) and Hungary (1980-2021). I will study the increased demand for manager skills after economic liberalization of the 1990s, the geographic and other frictions stopping managers from reaching their full potential at their ideal firm, and the spread of trading practices between firms as managers move. My research will show how the misallocation of manager skills across firms, space, and time can contribute to lower aggregate productivity.

Keywords: development accounting,management,assignment model,overlapping generations model,linked employer employee data
SMART EUROPEAN SHIPBUILDING (SEUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Countries involved: Norway,Germany,Netherlands,Finland,Spain
Call: Computational tools for shipbuilding (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 8590667.5
EU funding (EUR): 6992201.5
Participants: 12
Project status: SIGNED

The Smart European Shipbuilding project (SEUS) aims to create a framework for European shipyards by architecting and developing an integrated platform for a combined solution incorporating CAE, CAD, CAM, and PDM software and testing it at shipyards. The new platform solution will be built with the best EU shipbuilding expertise provided by academic and industrial consortium participants. It will develop novel practices for human-centric knowledge management, data-driven AI design elements, intelligent technology, and Industry 5.0 concept for shipbuilding. The consortium partners represent state-of-the-art development in three main areas: computational tools development, industrially applied research, and the end-users of the new technology – shipyards. The ambition is to achieve up to a 30% time-saving in engineering and up to 20% time-saving in assembly and construction at European shipyards. The elimination of gaps in digital information flows and the optimisation of work processes present the area for time and cost optimisation, providing significant economic impacts on shipbuilding. Identified impacts include development of computational platform solution, facilitation of digital transformation of shipbuilding, traceability and integration of early design impact the design process, competitive advantage for EU shipbuilders through time savings in design and production stages, expansion of shipyard’s exposure to ship’s life cycle: for retrofit, revitalisation, use of data from operation and maintenance, human-centric shipbuilding knowledge management, and EU workforce skills and expertise development. Each work package contributes to the main goal – the development of the new computational toolset, taking into account the target user groups’ needs, new research in industry and technology, integration and interoperability aspects of the platform, the novel human-centric approach, and the needed support processes for project management and dissemination.

Keywords: computational tools,shipbuilding,industry 5 0
Structure and functioning of novel seed-dispersal networks as a result of climate change (NETNOVO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Climate change is altering species distributions across the globe. Because in mutualistic interactions, as the ones between plants and seed dispersing animals, species rely on each other to persist, climate-driven species shifts have been shown to reduce areas of cooccurrence between mutualistic partners, breaking interactions, reducing ecosystem service provision, and causing co-extinction cascades. But so far, we have overlooked the ecological communities that species may face in their new distributions, and the novel ecological networks these communities may form. For instance, seed-dispersal interactions are mediated by species traits, such as the gape width of animals and seed sizes of plants, so that the climate-driven rearrangement of species traits may present new interaction partners, offering novel interaction opportunities through interaction rewiring, ultimately resulting in novel seed-dispersal networks. The aim of NETNOVO is to build and assess the structure, resilience and functioning of novel seed-dispersal networks under climate change. I will combine species trait data with climate, species distribution, and network assembly models to: O1) map the global loss and potential gain of seed-dispersal interactions under climate change, O2) predict the resulting novel seed-dispersal networks, and estimate their structure, and resilience, and O3) assess the seed-dispersal service that novel networks may provide. NETNOVO will not solely focus on interaction loss; instead, NETNOVO aims to shed light on the formation of novel ecosystems, an urgent enterprise which is beyond the state-of-the-art. Whilst increasing my international mobility and career development, expected NETNOVO results include three scientific publications, outreach activities to promote societal awareness on the effects of climate change on mutualistic interactions, and meetings with conservation agencies to discuss strategies to restore interactions.

Keywords: novel ecosystems,seed dispersal,species distributions,climate change