Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative high-sensitivity avalanche field-effect transistors designed for cancer diagnosis (HSAFE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Türkiye,Czechia,Hungary,Ukraine,Portugal,Poland,Azerbaijan
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 1807178.57
EU funding (EUR): 1618230.0
Participants: 9
Project status: SIGNED

The focus of the HSAFE project, which aligns with the specific objectives of the Marie Curie SE-2024 call, is to develop an ultrasensitive diagnostic tool necessary for the identification and detection of lung and lymphoma cancer cells at an earlier stage of development. Early detection significantly increases the chances of a complete cure for the patient. The project proposes to produce a new biosensor based on an avalanche FET array and innovative 2D materials to overcome some disadvantages of traditional cancer detection methods, such as being time-consuming, expensive, and lacking in sensitivity and specificity. The successful implementation of the project will be ensured by sharing the experience and knowledge gained in the fields of physics, technology, and engineering in a coordinated manner. Strengthening modern knowledge in the field of sensors and applying modern technological approaches and methods will be achieved through the international cooperation of highly qualified scientists and engineers from Azerbaijan, the Czech Republic, Hungary, Portugal, Poland, Turkey, and Ukraine. This consortium will address both technological (e.g., micro-sized sensor design, biosensor reader production) and fundamental (e.g., innovative material synthesis, internal avalanche amplification mechanisms of ultra-weak signals, biomarker immobilization process) issues.

Keywords: field effect transistor based biosensors,cancer diagnostic,diagnostic tools,and public health
Accelerating scale up and commercialisation of 100% bacteria free eggs for use in production of vaccines (Ovavax2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 3571428.75
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Ovagen is aiming to transform the egg-based production of vaccines and other biopharmaceutical medicines by producing the world’s first Germ Free egg and bringing it into mass production. The proposed programme of work will build on the groundwork initiated as part of the 30 month OvaVax project (GA 858390) and provides a logical expansion of this disruptive, innovative technology to the challenges facing the world as it comes to grips with COVID-19 and future pandemics with the need for rapid scale-up of vaccine production Ovagen is applying for EIC Accelerator funding to broaden the project scope of their existing H2020 SME Instrument Phase 2 to expand and accelerate the existing influenza project, to include COVID-19, Yellow Fever, Newcastle Disease and to include readiness for production and accelerated international scaleup of germ free egg production to increase global vaccine manufacturing capacity in readiness for future pandemics similar to COVID-19.

Keywords: global scale up,yellow fever,influenza,coronavirus,vaccine production,germ free eggs
Super-resolved stochastic inference: learning the dynamics of soft biological matter (SuperStoc)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1477856.25
EU funding (EUR): 1477856.0
Participants: 1
Project status: SIGNED

The dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in microscopy and tracking, there is today an abundance of experimental trajectories reflecting these dynamical laws. Inferring physical models from noisy and imperfect experimental data, however, is challenging. Because there are no inference methods that are robust and efficient, model reconstruction from experimental trajectories is a bottleneck to data-driven biophysics. I will bridge this gap by developing practical algorithms that permit robust and universal inference of stochastic dynamical models from experimental trajectories. To this aim, I will build data-efficient tools to learn stochastic differential equations and discover physical models, employing methods from statistical physics and machine learning. The main focus of SuperStoc will be in resolving models with high precision from limited trajectories. To assess the efficiency of the methods I develop, I will design information-theoretical frameworks to quantify how much can be inferred from trajectories that are short, partial and noisy. The convergence of the resulting algorithms will be backed by mathematical proofs and numerical simulations in realistic conditions. I will apply these new tools to several key open biophysical problems where existing methods are failing: condensate-mediated interactions between genomic loci, cellular mechanosensing in confined environments, pattern formation in embryo development, and visual interaction between fish leading to collective motion. The resulting algorithms will be implemented into a software designed to be useful for the broad soft biological matter community. By proving that one can do more with the same data and providing tools to do so, SuperStoc will help bridge the inference gap towards data-driven biophysics.

Keywords: stochastic processes dynamics of biological systems inference and inverse methods data analysis algorithm development cell dynamics
Microbial activity at the Bentonite barrier in a deep geological nuclear waste repository (MicroBent)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-16
End date: 2025-03-15
Duration (months): 34.0
Total project cost (EUR): 201714.48
EU funding (EUR): 201714.48
Participants: 2
Project status: CLOSED

Management of nuclear waste is a serious worldwide environmental problem all. Deep geological repositories have been internationally proposed as the safest option for the disposal of these hazardous materials. The concept is based on a multi-barrier storage system with waste containers, surrounded by a bentonite buffer buried deeply within a stable geological formation. The bentonite formations in Almeria were characterized as a bentonite buffer reference material. However, few studies have described the influence of the microbes in the repository under in situ conditions, although its safety can be compromised not only by physical and chemical factors, but also by biogeochemical activity. Therefore, the hypothesis to be tested in this proposal is that indigenous microorganisms may play an important role for the safe disposal of nuclear waste. The main objective of this proposal is to study the microbial diversity and activity of the bentonite buffer under in situ conditions for a repository of radioactive waste. To address these points the following objectives will be carried out under in situ conditions: 1) to characterize the mineralogical and geochemical composition of the bentonite buffer 2) to determine the microbial of the incubated bentonite buffer 3) to determine the microbial activity of the incubated bentonite buffer. This proposal will extend the state-of-the-art for nuclear waste repositories by identifying active microorganisms in compacted bentonites and natural deep groundwaters and active microbial metabolic pathways. These vital questions need to be addressed to ensure the safety of the deep geological repository of nuclear waste, but also for other biotechnological uses like bioremediation of contaminated sites.

Keywords: rna,dna,deep geological repository,highly radioactive waste
Carbon Neutral Milk (CANMILK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: Finland,Belgium,Netherlands,Germany,United Kingdom,Portugal
Call: Technologies for non- CO2 greenhouse gases removal (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2027-02-28
Duration (months): 54.0
Total project cost (EUR): 2572693.5
EU funding (EUR): 2572693.25
Participants: 8
Project status: SIGNED

The challenge of agricultural GHG emissions is that they are highly diluted and originate from more than 10 million European farms. Thus, local emissions are small but the combined contribution on European level is ca. 10% of total GHG emissions. A significant portion of these is methane (ca 43 %), and most of that is produced by enteric fermentation, i.e. by belching cattle. Viable technical solutions do not exist for methane abatement, and new developments are urgently needed to meet the targets set by Methane Strategy, Farm to Fork Strategy and Fit for 55 legislation package for agricultural carbon neutrality in 2035. They must have high potential for commercialization, be efficient in methane abatement and costs must be affordable for the farmers. CANMILK will develop technology that is simple to use and has low maintenance, with overall cost below 80 €/t CO2-eq. A non-thermal plasma, or cold plasma, is today in everyday use e.g. in fluorescent lamps and ozone generators. CANMILK project will utilize this technology in a novel and innovative way in the fight against methane. The work is focused on the methane activation by plasma derived oxygen or hydrogen species enabling methane decomposition with the help of catalysts at mild conditions. As a result we expect to get 1) a simple and efficient equipment for methane abatement in dairy and meat cattle barns, 2) a good view of the socio-economic and environmental feasibility of plasma-based methane abatement and 3) increased public, scientific and industrial awareness of feasible solutions available for GHG abatement in agriculture. Our estimate for the efficiency of the CANMILK technology is 90% methane conversion, which in case of maximum utilization in barns would lead to total GHG abatement of ca. 140 Mt CO2-eq/a in Europe. This would have significant positive impacts to farmers, rural communities, consumers and industry in the transition of the European economy towards more carbon neutral, sustainable future.

Keywords: methane abatement,plasma,catalysts,agriculture,enteric methane,dairy industry
Post Born-Oppenheimer Approximation for Semiclassical Spectroscopy Investigation of Proton-Coupled Electron Transfer Processes (NEOSC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2027-01-31
Duration (months): 37.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 2
Project status: SIGNED

The Born-Oppenheimer Approximation (BOA) has determined how chemists describe molecules since 1927. BOA separates electronic and nuclear degrees of freedom, considering that the electron timescale is much shorter than the nuclear one. This assumption does not hold in Proton Coupled Electron Transfer (PCET) processes. PCET is the key to efficiency in biological photosynthesis. Time-Resolved Infrared spectroscopy (TRIR) assists PCET investigations but it is usually interpreted with harmonic frequency calculations or classical nuclear dynamics simulations on a BO potential energy surface. To gain further physical insights into PCET it is necessary to revise the theoretical framework for spectroscopy, going beyond the BOA and including a quantum treatment for all nuclei. To reach this goal, this project unifies two cutting-edge methods. One is the Nuclear Electronic Orbital (NEO) approach that goes beyond the BOA by including into the electronic structure calculations the PCET transferred proton. The other is the Semiclassical Initial Value Representation technique that simulates IR spectra by accounting for quantum effects, such as the zero-point energy, overtones, or tunneling, for all nuclei, even in large molecular systems. The project will introduce a new post-BOA conceptual picture for vibrational spectroscopy. Specifically, semiclassical nuclear density calculations will be used to tailor new basis sets to efficiently simulate large molecular systems, gradually including many protons and other nuclei in the NEO wavefunction. In this way, a new spectroscopy theory will be developed for the simulation of TRIR spectra at semiclassical accuracy on NEO post-BOA PESs. These advances will be implemented in an open-source code that we employ to study prototypical PCET systems and gain accurate mechanistic information. This new knowledge will foster applied research by exploiting a deeper understanding of the PCET processes.

Keywords: non adiabatic processes pcet semiclassical dynamics neo vibrational spectroscopy
UTOPCYCLE: THE SOCIAL MOVEMENT OF PLATFORM COOPERATIVES IN BIKE DELIVERY (UTOPCYCLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: SIGNED

In delivery sector, in contrast to the platform utopia of a “data-driven business”, cooperative platforms oppose the utopia of delivery without exploitation nor carbon emissions. This project focuses on two cooperatives: Rayon9 in Liège and Les Cargonautes in Paris along with one international network Coopcycle. Its originality lies in understanding them both in the light of the concept of « embedding ». These cooperative platforms are at the forefront of the “counter-movement” by which society is defending itself against “uberisation”. But this complex and multi-directional process not only engages public authorities and regulation at a local, national or international level. It is also emerging from below, thanks to alternative socio-economic forms such as bike delivery cooperatives. This project mobilizes the tools of the sociology of work and social movements in the theoretical framework of a political economy of (re-)embeddedness. It makes the choice of an interdisciplinary approach to break down barriers between the fields of labour studies and social movement studies. It goes beyond the state of the art by intending to operationalize the concept of embeddedness in the context of "cyclologistical revolution". It proposes an European investigation in a participatory-design research where the problematization is built from the field. This research protocol targets Rayon9 and Les Cargonautes both specializing in the last-mile sector e.g. deliveries by cargo bike with electric assistance. This last link in the chain is also the most expensive and the most polluting, creating a real logistical headache. This comparative ethnographic study is composed of two research axes. First, it analyses the cyclologistical transformation of bike delivery in platform cooperatives highlighting its political dimensions. Second, it aims to understand what makes re-embedding of bike delivery possible or not, addressing the challenge of inter-cooperation.

Keywords: platform cooperativism uberisation workplace democracy cyclelogistic
Innovative Value Chains for European Ceramic Oxide Fibres (InVECOF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Germany,France,Netherlands,Austria,Czechia
Call: Building innovative value chains from raw materials to sustainable products (IA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-05-01
End date: 2025-10-31
Duration (months): 42.0
Total project cost (EUR): 8759238.75
EU funding (EUR): 7110470.25
Participants: 11
Project status: SUSPENDED

Oxide fibre reinforced ceramics, so-called oxide ceramic matrix composites (O-CMC) have to be considered as strategic materials from now to the future, e.g. for use in next generation aero-engines, stationary gas turbines, power-to-X processes with concentrated solar power CSP, chemical industry, batch carrier for high temperature processes, etc. Today such high-end O-CMC components and the key raw material, the ceramic fibres as reinforcement component, are mainly exclusively produced in the United States. But as these are key components for the European manufacturing, energy and aerospace industry, there is a need to develop a European oxide fibre and O-CMC component industry, decreasing dependence on non-EU producers. The InVECOF project addresses this need and provides a substantial contribution to sustainable product innovation action through the two following key activities: 1. to develop a European oxide ceramic reinforcing fibre equivalent to US fibres and to establish it among end users (ROF fibre) and 2. to develop and validate a next-generation fibre in parallel with improved thermos-mechanical properties (NGO fibre). The ROF fibre will present an equivalent to the dominant 3M Nextel fibres with better availability, without dual-use restrictions from the US and possibly lower price is needed and the NGO fibre will have improved thermo-mechanical properties compared to the benchmark fibres in order to make processes, plants, turbines, etc. more energy efficient through higher application temperatures. The project InVECOF Innovative Value Chains for European Ceramic Oxide Fibres covers the whole process chain beginning from fibre development and production over weaving these fibres to fabrics to O-CMC manufacturing, coupons and demonstrators for every end-user application, up to testing Ox-fibers and O-CMC components in relevant environments with project partners for every step from three countries in Europe.

Keywords: oxide fibres,oxide ceramic matrix composites,key raw material
ARISE - Advanced RNA Inhalation Solutions anchored in Evolved dry powder technology. (ARISE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 3459283.93
EU funding (EUR): 2421498.75
Participants: 1
Project status: SIGNED

One of the main challenges in the domain of respiratory RNA delivery has been administration. Today, while 15 RNA therapeutics are undergoing clinical trials for pulmonary diseases, none has yet secured regulatory approval. Our nano-embedded microparticles (NEMs) represent a disruptive approach and paradigm shift in the field of RNA therapeutics for the treatment pulmonary diseases. Our IP-protected NEM technology comprises therapeutic RNA, which is encapsulated in lipid nanoparticles (LNPs) and formulated as an inhalable dry powder. This innovation builds the foundation to RNhale's two-pronged business concept: in-house drug development and RNA formulation in R&D partnerships. In brief, we have developed a standalone approach, pioneering an RNAi-based drug candidate for the treatment of moderate and severe allergic asthma. Additionally, our scalable, and indication independent production technology of RNA-loaded dry powders will be a second mainstay of our commercialization strategy.

Keywords: biotech,asthma,inhalation,pulmonary indications,lnp rna,spray drying technique,dry powder inhalers,manufacturing process
Desmoplastic Small Round Cell Tumor on the spotlight: introducing CAR-T cell therapy. (DSRCT-CAR)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: SIGNED

Desmoplastic small round cell tumor (DSRCT) is an aggressive rare sarcoma that occurs in adolescents and young adults. DSRCT has a dismal prognosis: despite aggressive therapy, 3-year overall survival has been estimated at 44% and the 5-year survival rate remains around 15%. Current therapeutic approaches, including chemotherapy (remain highly toxic) and surgery, are yet to achieve complete disease control. The development of safe and efficient molecularly targeted-therapies, as well as a comprehensive understanding of the molecular driver of the disease, are highly needed to ultimately improve patient outcome. The originality of this proposal relies on intersecting complementary scientific areas, as the high level of maturity I have acquired both on the molecular basis of DSRCT and on the corresponding cellular and animal models, and a novel form of immunotherapy, as CAR-T cells (which the host group is actively working on), for the treatment of DSRCT. It will be carried out under the guidance of Prof. Moreira from CNC/UC, who holds more than 25 years of experience in the field of targeted delivery to solid tumors and successful entrepreneur. This Fellowship, in line with Europe Mission on Cancer, is a life time opportunity that will enable me to become a highly qualified researcher, with differentiated background (combining – existing - molecular cancer pharmacology with targeting strategies to solid tumors) and novel transferable skills, among the post-doc universe entering the job market. It will enable me to generate and integrate interdisciplinary knowledge with added economic value, with know-how on how to translate it towards the market and the patients. Overall, these are relevant features to support the sustainability of any organization. As such, approval of this Marie Sklodowska-Curie European Fellowship will give me a wide avenue of opportunities to further pursue a career either in Academia or Pharmaceutical Industry.

Keywords: sarcoma target discovery targeted therapy car t cells