Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated evolutionary analyses of genetic and drug interaction networks in yeast (NETWORK EVOLUTION)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Hungary
Call:  (ERC-2007-StG, 2007)
Start date: 2008-07-01
End date: 2013-06-30
Duration (months): 60.0
Total project cost (EUR): 1280000.0
EU funding (EUR): 1280000.0
Participants: 1
Project status: CLOSED

The ability of cellular systems to adapt to genetic and environmental perturbations is a fundamental but poorly understood process both at the molecular and evolutionary level. There are both physiological and evolutionary reasonings why mutations often have limited impact on cellular growth. First, perturbations that hit one target often have no effect on the overall performance of a complex system (such as metabolic networks), as perturbations can be adjusted by reorganizing fluxes in metabolic networks, or changing regulation and expression of genes. Second, due to the fast evolvability of microbes, the effect of a perturbation can readily be alleviated by the evolution of compensatory mutations at other sites of the network. Understanding the extent of intrinsic and evolved robustness in cellular systems demands integrated analyses that combine functional genomics and computational systems biology with microbial evolutionary experiments. In collaboration with several leading research teams in the field, we plan to investigate the following issues. First, we will ask how accurately genome-scale metabolic network models can predict the impact of genetic deletions and other non-heritable perturbations. Second, to understand how the impact of genetic and drug perturbations can be mitigated during evolution, we will pursue a large-scale lab evolutionary protocol, and compare the results with predictions of computational models. Our work may suggest avenues of research on the general rules of acquired drug resistance in microbes.

Keywords: metabolic networks,flux balance analysis,mutational robustness
Emergence of Research Driven Clusters in Central Europe (ERDC)

Framework: FP7 — Capacities
Programme: Regions of Knowledge
Destination: Facilitating the emergence of new regional research driven clusters and mutual exchange of information
Action type: Coordination and support actions
Countries involved: Slovakia,Slovakia,Austria,Slovakia
Call:  (FP7-REGIONS-2007-2, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 212598.14
EU funding (EUR): 190000.0
Participants: 8
Project status: CLOSED

The project aims to contribute to the development of research driven clusters in Europe with specific focus on convergence regions in central Europe. The objectives of the project are: a) Development of a methodology for establishment of research driven clusters in new member states in the Central European region and in other convergence regions; b) Dissemination of the developed methodology through out the European convergence regions and c) Establishment of a research driven cluster in Slovakia focused to specific sector. The project will consists from analytical part carried out in the specific region, targeted activities will be carried out in order to launch research driven cluster in the region. Based on local experience, the methodology for research driven cluster establishment in convergence regions will be prepared for dissemination in other convergence regions in Europe. In the framework of the project the workshops will be carried out in 4 Central European countries in order to collect feedback on proposed methodology and Central European dissemination event will be organized to present final methodology of the project. The project also aims to contribute to co-ordination activities in the area of research driven clusters emergence which will be reflected in dissemination plan for proposed methodology and in this respect will benefit from expertise of experienced Austrian partner in the project.

Keywords: clusters,smes
Flow visualization inspired aero-acoustics with time-resolved Tomographic Particle Image Velocimetry (FLOVIST)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: Netherlands
Call:  (ERC-2007-StG, 2007)
Start date: 2008-08-01
End date: 2013-07-31
Duration (months): 60.0
Total project cost (EUR): 1498000.0
EU funding (EUR): 1498000.0
Participants: 1
Project status: CLOSED

The recent developments of the Tomographic Particle Image Velocimetry technique and of the non-intrusive pressure field characterization method, by the applicant at TU Delft Aerospace Engineering, now opens unforeseen perspectives in the area of unsteady flow diagnostics and experimental aero-acoustics. As a result of this work it is now possible not only to quantify complex flows in their three-dimensional structure, but also to extract quantities such as pressure. The current research proposal aims at the development of an innovative approach to experimental aero-acoustics and flow control making use of the recently developed Tomographic-PIV technique. The objective is to fully describe and quantify the flow pattern and the related acoustic source term at its origin, which is of paramount importance to understand and control the processes like acoustic noise production and flow separation dominating aerodynamic drag. This is relevant for the improvement of aircrafts design as far as drag reduction and noise emission is related and should enable the development of "greener" aircrafts for a sustainable growth of aviation in populated areas, in harmony with the technology innovation policy in Europe (7th Framework Programme) and TU Delft sustainable development focus (CleanEra, Cost-Effective Low emission And Noise Efficient regional Aircraft) at Aerospace Engineering. To achieve this step it is required that such new-generation diagnostic approach by the Tomo-PIV technique is further developed into a quadri-dimensional measurement tool (4D-PIV), enabling to extract the relevant acoustic information from the experimental observation invoking the aeroacoustic analogies. A wide industrial and academic network (DLR, AIRBUS, DNW, NLR, LaVision, EWA, JMBC Burgerscentrum) developed in recent years is available to exploit the results of the proposed activity.

Keywords: particle image velocimetry,tomography,aero-acoustics
European Centre of Excellence in Microwave, Millimetre Wave and Optical Devices, based on Micro-Electro-Mechanical Systems for Advanced Communication Systems and Sensors (MIMOMEMS)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Romania
Call:  (FP7-REGPOT-2007-1, 2007)
Start date: 2008-05-01
End date: 2011-04-30
Duration (months): 36.0
Total project cost (EUR): 1233645.6
EU funding (EUR): 1100000.0
Participants: 1
Project status: CLOSED

The aim of the MIMOMEMS project is to bring the research activity in RF and Optical-MEMS at IMT-Bucharest to the highest European level and create a European Centre of Excellence in Microwave, Millimetre Wave and Optical Devices, based on Micro-Electro-Mechanical Systems (MEMS) for Advanced Communication Systems and Sensors The main objectives of the project support high level research activities in RF and Optical MEMS, through the following objectives: i. Know-How and Experience Exchange: Twinning actions with two research centres: a) LAAS-CNRS Toulouse with a strong expertise in silicon based millimetre wave microsystems and photonic devices, and b) FORTH-IESL-MRG Heraklion with excellent knowledge of IIIV’s ii. Recruitment by IMT:. Post-Docs. with expertise in nanophotonics and microwaves, will be hired for increasing IMT s human potential iii. Development and Upgrade of Research Equipment: About 50% of project founds will be used for the upgrading and purchasing new equipments (on wafer characterization up to 110GHz, new nano-characterization equipment –SNOM, etc) iv. Workshop, Conference Organisation and Policy Development. Organize of scientific events, thematic sessions and seminars supporting knowledge transfer and research policy development v. Dissemination and Promotional Activities: Promotion of activities and results through a project website; publication in reviewed journals and conferences; organization of workshops, FP7 proposals. The MIMOMEMS project will directly address research objectives from FP7 Work Programmes: 1.Capacities - Part 4 - Research Potential. Activity: 4.1.Unlocking and developing the research potential in the EU´s convergence regions and outermost regions 2.Cooperation – Theme 3 - ICT. Challenge 3: Components, systems, engineering:3.1; 3.5; 3.6 Objective.3.1: Next-Generation Nanoelectronics Components and Electronics Integration Objective.3.5: Photonic components and subsystems Objective 3.6: Micro/nanosystem

Keywords: silicon,gaas,micromachining,membranes,receivers,saw,baw,filters,antenas,optical mems,workshops,seminars,upgrading equipment
ERA-NET for Nuclear Physics Infrastructures (NUPNET)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: France,Germany,Germany,Italy,Spain,Belgium,Bulgaria,Czechia,Finland,Greece,Hungary,Netherlands,Poland,Romania,United Kingdom
Call:  (FP7-INFRASTRUCTURES-2007-1, 2007)
Start date: 2008-03-01
End date: 2011-11-30
Duration (months): 45.0
Total project cost (EUR): 1482084.63
EU funding (EUR): 1300000.0
Participants: 19
Project status: CLOSED

To face the increase in the complexity of facilities, and the cost and technical demands in a global context of international user groups and expertise, 18 European Funding Agencies representing 14 countries have decided to submit an ERA-NET project to provide Europe with a more coherent funding of its Nuclear Physics Infrastructures and equipments. The project will ensure exchange of information, the definition of joint activities, and their launch through one or more concrete pilot actions. The success of the activities within the scope of the project will be a major achievement in the field and will have a strong impact on the present and future European landscape of Research Infrastructures.

Keywords: infrastructures nuclear physics eranet
Keratin Intermediate Filaments as Regulators of Epithelial Intracellular Organization Keratin intermediate filaments are cytoskeletal proteins regulating the polarity and intracellular organization (KIFREIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-01-01
End date: 2011-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Keratin intermediate filaments are cytoskeletal proteins regulating the polarity and intracellular organization of epithelial cells, influencing interactions of epithelia with the surrounding environments. This is particularly relevant in the intestine, where a single cell layer of epithelial cells form a barrier between the luminal content and the underlying tissues. Keratin 8 (K8) null mice develop an ulcerative colitis-like inflammatory bowel disease (IBD) that responds to antibiotic therapy. K8 null colonocytes also mistarget ion transporters in association with abnormal chloride transport and diarrhea. The unexpected connection between K8 and colitis led to a proteomic approach, showing decreased expression of the ketogenic enzyme mHMG-CoAs in K8 null colonocytes. K8 null mice also develop autoantibodies against mHMG-CoAs. These findings raise the hypothesis that colonic keratins modulate ketone body metabolism, which is relevant to the IBD phenotype, since bacteria regulate mHMG-CoAs through butyrate, a major colonocyte energy source. The aims are to use microarray data to identify differences in K8 null ketone body metabolism and verify findings by inducing ketogenesis and measuring the ramifications of a blunted pathway. Mistargeting of butyrate transporters will also be investigated. K8 mutations predispose to liver disease but the role in IBD is unknown. Apart from contributing to the understanding of the biological roles of keratins, including ketone body metabolism, the study has broad ramifications for patients suffering from the common and incapacitating IBD-conditions, for patients with keratin mutations, and may aid in developing diagnostic/therapeutic modalities. I wish return to Europe and establish myself as a Finnish investigator after advanced training at Stanford University. The Turku-BioCity environment combined with my unique skills and collaborative networks with Stanford University provide excellent prospects for a fruitful synergy.

Keywords: keratin,intermediate filament,cytoskeleton,epithelia,colon,digestive tract,inflammatory bowel disease,ketone body metabolism,lipid metabolism,ion transport,animal model,membrane targeting
Nano fibrous materials - structure, design and application (NANOFIB)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: Belgium
Call:  (ERC-2007-StG, 2007)
Start date: 2008-07-01
End date: 2013-06-30
Duration (months): 60.0
Total project cost (EUR): 1228736.0
EU funding (EUR): 1228736.0
Participants: 1
Project status: CLOSED

The performance and physical attributes of a material and product can be tailored to so far unmatched material strengths and properties by creating new nano fibrous structures from polymers by electrospinning. The electrospinning process uses an electric field to produce charged jets of polymer solutions or melts. Bending instabilities of the jet, caused by the surface charge, lead to extremely high local extension rates of the jet and produce fibres with diameters of the order of a few nanometer that consist of highly aligned polymer strands. However, the biggest unsolved problem of the electrospinning process is the sensitive equilibrium between surface tension, viscosity, elasticity and conductivity of the polymer solutions. These are controlled by molecular parameters as the molar mass, chemical microstructure, conformation in solution or supramolecular structures via intermolecular interactions. The optimal combination of these parameters is, as yet, unknown. Within this project, a novel and unique technical platform will be developed and installed, that is generally capable to image and analyse high speed free surface flows in miniaturised dimensions. This platform will then be utilized to analyse electrospinning process parameters and to connect them to the material properties and the molecular structure of the polymer solution. Only such a fundamental understanding of the relation of these properties to the flow and mass transfer phenomena on the micro-time and -dimensional scale will allow to design in the second part of this project the required structural and material properties of nano-scale fibres for: -novel fibre/matrix composites for the creation of ultra-high-strength hydrogel membranes; -short fibre morphologies created by a novel controlled disruptive spinning process at the boundaries of the parameter space; -tailoring of fibre properties from renewable resources by modification of the chemical side-chain structure of polysaccharides.

Keywords: electrospinning,nano fibres,composite materials,polymer alignment
Contour dynamics and singularities in incompressible flows (CDSIF)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Spain
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2013-08-31
Duration (months): 60.0
Total project cost (EUR): 650000.0
EU funding (EUR): 650000.0
Participants: 1
Project status: CLOSED

The search of singularities in incompressible flows has become a major challenge in the area of non-linear partial differential equations and is relevant in applied mathematics, physics and engineering. The existence of such singularities would have important consequences for the understanding of turbulence. One way to make progress in this direction, is to study plausible scenarios for the singularities supported by experiments or numerical analysis. With the more sophisticated numerical tools now available, the subject has recently gained considerable momentum. The main goal of this project is to study analytically several incompressible fluid models. In particular solutions that involve the possible formation of singularities or quasi-singular structures.

Keywords: partial differential equations,incompressible fluids,euler equations.
Tarski’s Revolution: A New History. Semantics and Axiomatics from Bolzano to Tarski against the background of the Classical Model of Science (TRANH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Environment and society
Countries involved: Netherlands
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2013-08-31
Duration (months): 60.0
Total project cost (EUR): 897472.0
EU funding (EUR): 897472.0
Participants: 2
Project status: CLOSED

This project aims at rewriting the history of Tarski’s revolution in semantics by taking into account the development of axiomatics from Bolzano to Tarski. Bolzano’s extraordinary work in semantics has been especially significant for the Polish tradition to which Tarski belongs, and Tarski’s ideas in turn changed the course of contemporary analytic philosophy. Tarski’s work represents a crucial turn in the history of semantics and related fields. The research project aims to establish that the turn at issue must be interpreted in connection with the development of axiomatics in Poland. In particular, the project proposes to interpret Tarski’s turn on the basis of a new framework, the Classical Model of Science, which systematises a general axiomatic ideal of scientific knowledge. The ideal goes back to Aristotle’s “Analytica Posteriora” and has been highly influential for more than two millennia. The interpretation proposed is radically new with respect to existing ones. It is also the only one to offer a convincing account of elements of both continuity and discontinuity in the historical tradition under investigation. The project divides into three subprojects: (I) 'Semantics and Axiomatics in Bolzano against the background of the Classical Model of Science'; (II) 'Semantics and Axiomatics in Tarski against the background of the Classical Model of Science'; (III) 'Semantics and Axiomatics from Bolzano to Tarski against the background of the Classical Model of Science'. The research will be carried out on the basis of original Polish and German sources by a team formed by myself (Project III) and two new members to be appointed, one at PhD level (Project I) and one at Postdoc level (Project II). The project will set a new course in the fragmented field of research on Tarski’s work and its roots and open new perspectives for neighbouring fields. It will also bring to the spotlight the Eastern European analytic tradition, still largely unexplored today.

Keywords: axiomatics,semantics,tarski,polish philosophy,lesniewski,bolzano,frege,austrian philosophy
Bimanual Rehabilitation System for Distal Upper Extremity Therapy (REHAB-DUET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-07-01
End date: 2012-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Assistance of repetitive and physically involved rehabilitation exercises through use of robotic devices not only helps eliminate the physical burden of movement therapy for the therapists, but also decreases application related costs. Moreover, robot mediated rehabilitation therapy allows quantitative measurements of patient progress and can be used to realize new treatment protocols. In the literature, beneficial effects of robot assisted rehabilitation over conventional therapy have been shown through clinical trials. In this project, development and testing of a robot assisted rehabilitation system for treatment of upper extremity motor dysfunction secondary to neurological problems is proposed. The project involves a) design and manufacturing of powered exoskeletons to assist forearm and wrist rotations, b) derivation and implementation of bilateral control techniques, c) synthesis of bilateral and tele-operated control/assistance methods that will allow users to practice self-induced therapy through use of their healthy arms, and d) design of human subject experiments to test efficacy of the developed assistance methodologies. The primal novelty of the proposed project comes form the system design that allows bilateral and teleoperated assistance schemes. The design is aimed to serve as an investigation and development platform for new treatment and assessment techniques while also being capable of implementing conventional treatments. A self-assisted therapy concept is proposed that has the potential to have a profound and lasting influence the way rehabilitation therapies are delivered. Targeting the distal parts of upper extremities, the proposed bilateral system is first of its kind in the literature. Moreover, the proposed exoskeleton has a novel parallel kinematic structure that allows independent control and monitoring of wrist rotations about a specified axis.

Keywords: rehabilitation robots,bilateral control and teleoperation,exoskeletons,hapic interfaces,force feedback assistance,human subject experiments