Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Partitioning And Transmuter Research Initiative in a Collaborative Innovation Action (PATRICIA)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Italy,Germany,Spain,Italy,Italy,Belgium,Sweden,Sweden,Korea, Republic of,Russian Federation,Romania,Switzerland,Switzerland,Belgium,Belgium,Finland,France,Czechia,Netherlands,United States,Netherlands,United Kingdom,United Kingdom
Call: Safety Research and Innovation for Partitioning and/or Transmutation (NFRP-2019-2020, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 8415315.63
EU funding (EUR): 6499979.5
Participants: 28
Project status: SIGNED

Climate change is one of the main issues facing humanity. Due to its low CO2 emission, nuclear power is part of a sustainable energy mix. However, safety and waste issues cannot be taken lightly. For the latter the way forward is to recycle spent fuel with the goal to close the fuel cycle. This eases ultimate radioactive waste management, increases proliferation resistance and drastically improves economy and sustainability by better use of fuel resources. The SNETP deployment plan describes a technical needs fuel recycling including partitioning of spent fuel, fabrication and characterisation of minor actinide bearing fuel and the development of transmutation systems. This proposal follows that plan and answers to NRFP7 of the 2018-2019 EURATOM call: Research and Innovation for Partitioning and/or Transmutation. It focusses on research on advanced partitioning to efficiently separate Am from spent fuel, on experimental and fuel performance code development work studying the behaviour of Am bearing fuel under irradiation and on the safety related research supporting the licensing process of MYRRHA in its role in the development trajectory for a dedicated accelerator driven transmuter. It may be noted that for first time, the communities working of partitioning, transmutation and the development of MYRRHA are joint in one project. Besides the technical work described above, dedicated work packages deals with education focussing on pre-and post-graduate students, and with dissemination where besides the specific stakeholders also high school pupils and the general public is targeted. A further task on knowledge management includes the both foreground data as well as metadata to so ensure proper QA for V&V is possible. The project is performed using a combination of experiments, theoretical studies and numerical simulations for which the expertise of 25 research centres and universities from 11 EU countries, Switzerland and the US is pooled.

Keywords: partitioning,transmutation,nuclear waste,myrrha
In Vivo Spectral Photon Counting CT Molecular Imaging in Cardio- and Neuro-Vascular Diseases (SPCCT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Israel,Belgium,France,Netherlands,United Kingdom
Call: Development of new diagnostic tools and technologies: in vivo medical imaging technologies (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 6441663.75
EU funding (EUR): 6441663.75
Participants: 11
Project status: CLOSED

The objective of the SPCCT project is to develop and validate a widely accessible, new quantitative and analytical in vivo imaging technology combining Spectral Photon Counting CT and contrast agents, to accurately and early detect, characterize and monitor neurovascular and cardiovascular disease. Spectral Photon Counting Computed Tomography (SPCCT) is a new imaging modality, currently in development, with a totally new type of detection chain designed to provide high count-rate capabilities while offering energy discrimination with high spatial resolution of 200µm. Based on this discrimination, SPCCT can detect and quantify accurately a large variety of atoms (including Gadolinium, Gold, Bismuth…) by using the K-edge technique. SPCCT, by a more accurate, less invasive (in comparison with IVUS and coronary angiography) and reliable evaluation of vascular inflammation will allow earlier disease diagnosis such as plaque inflammation before rupture, leading to improved clinical decisions and outcomes. This will be achievable with a high spatial resolution combined to the newly developed vascular inflammation specific contrast agent detected with high quality K-edge technique that can only be provided by a multi-spectral X-ray system. The project will therefore provide a complete tool (acquisition system and specific probes) dedicated to CV imaging. It will finally contribute to: Improved early diagnosis of atherosclerosis, prevention of acute event (MI, stroke) and personalized preventive treatment; Improved management of patient presenting with an acute CV event and clinical validation of treatment efficiency; Sustainability and harmonization of healthcare systems, as costly disorders of heart failure and stroke-related disability would be better prevented and efficiently treated; Economic growth in the EU diagnostics sector, through the development of new targeted contrast materials for SPCCT by SMEs.

Keywords: imaging,contrast agent,atherosclerosis,stroke,acute myocardial infarction,spectral photon counting computed tomography,nanotechnology
Enhancing CHO by Mammalian Systems Biotechnology (eCHO systems) (eCHO Systems)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Ireland,Germany,Germany,Estonia,Austria,Belgium,Netherlands,United Kingdom,Denmark,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 4044794.43
EU funding (EUR): 4044793.68
Participants: 18
Project status: CLOSED

Chinese hamster (CHO) ovary cells are the production host for a +50 billion €/yr biopharmaceuticals market. Current CHO production platforms dates to 1980 and are based primarily on media and process optimisation with little consideration to the optimization of the cellular machinery. Fortunately, with the recent sequencing of the CHO genome, an opportunity has opened to significantly advance the CHO platform. The benefit will be advanced production flexibility and a lower production cost. This ITN graduate training programme - eCHO Systems - will blend conventional molecular, cellular, and synthetic biology with genome scale systems biology training in ‘omics data acquisition, biological network modeling, and genome engineering in three interdisciplinary topics: 1) Acquisition of large scale ‘omics data sets and their incorporation into genome-scale mathematical models 2) Development of genome engineering tools, enabling synthetic biology 3) Application of systems and synthetic biology and genome engineering to improve performance of CHO producers The training projects are supported by 15 industrial participants, which will participate in the research and test the results. ESR training will include intense courses focused on computational systems biology, cell biology, business and entrepreneurship. The three universities bring unique complementary skills in systems and synthetic biology, ‘omics technologies, cytometry, and molecular cell biology which will provide depth and breadth to this training. The eCHO Systems will produce four major outputs: General knowledge to improve the productivity, quality, and efficiency of CHO platform cell lines, new systems models for CHO cells, new CHO cell line chassises generated through synthetic biology approaches, high quality education at the graduate level, and a cadre of interdisciplinary graduates poised to transform biopharmaceutical biotechnology.

Keywords: systems biology biopharmaceuticals industrial biotechnology,synthetic biology
Translation and Commercialization of a QSOX1-inhibitory Antibody Targeting the Tumor Microenvironment in Breast Cancer (CONQR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-12-01
End date: 2020-05-31
Duration (months): 18.0
Total project cost (EUR): 149998.0
EU funding (EUR): 149998.0
Participants: 1
Project status: CLOSED

The high number of cancer cases worldwide points to the large global demand for therapeutics for adenocarcinomas (the majority of lung, breast, and pancreatic cancers). Cancer metastases cause more than 90% of cancer patient deaths. There is thus great need to develop more targeted cancer therapies, as well as therapies that enhance the delivery and penetration of chemotherapies to reduce side effects and increase efficacy. A specific societal need is improved therapies for triple-negative breast cancer (TNBC), to which the targeted therapies developed for other breast cancers are not applicable. TNBC treatment, particularly for women with BRCA1 gene mutations, typically involves aggressive chemotherapy, mastectomy, and radiation treatment, with preventive oophorectomy also recommended. The physical and psychological impact of this regimen on young mothers and their families is unquantifiable, and the risk of relapse imposes continuing psychological stress. We have made a revolutionizing discovery that significantly controlled cancer cell adhesion, cell migration, primary tumor growth, and metastasis. We found that inhibition of the secreted enzyme QSOX1 by a monoclonal antibody inhibitor counteracts extracellular matrix ECM matrix stiffening and prevents tumor cell adhesion and migration. The QSOX1 inhibitor showed an added benefit in controlling primary tumor growth and metastasis when provided together with standard chemotherapy in a TNBC model in mice. The antibody drug we are developing based on these exciting discoveries has great promise for commercialization as a new therapeutic agent for TNBC and for other oncology indications. The goal of the CONQR project is to perform key preclinical experiments and explore market entering opportunities for commercialization of a novel QSOX1-inhibitory reagent against ECM remodeling in cancer. The intended outcome will be a development and commercialization plan to best position the product for out-licensing.

Keywords: commercialization,monoclonal antibody,qsox1 inhibitory reagent,therapeutics,adenocarcinoma,triple negative breast cancer,tnbc
Intercultural Theatre And Cultural Appropriation (ITACA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2023-03-31
Duration (months): 30.0
Total project cost (EUR): 199760.16
EU funding (EUR): 199760.16
Participants: 2
Project status: CLOSED

The ITACA project (Intercultural Theatre And Cultural Appropriation) intends to explore the complex phenomenon of cultural appropriation in contemporary theatre with the aim of setting up a form of theatre aesthetics. The objective is to probe the themes constituting and defining the very origin of theatre, so as to discover their aesthetic and ethical categories, using the lens of cultural appropriation: i.e. the way a historically dominant culture uses and transforms features of a marginalized culture. Cultural appropriation is considered in the context of Quebec theatre and compared to some examples of intercultural theatre in Italy. In the belief that theatre is an ideal philosophical tool by which to explore the relationship between identity and otherness, ITACA proposes to explore that relationship as found in our post-colonial, globalized society and insofar as Europe compares with North America. To achieve its objective ITACA foresees a research and training project between Canada and Italy combining philosophical theory with theatre practice in an interdisciplinary framework. ITACA is open to a multidisciplinary approach, ranging from political science to new media, the study of Quebec culture and digital globalization, and understanding the urgent and relevant theme of cultural appropriation. These theoretical studies are anchored to a programme of Research-creation allowing one to work practically alongside Canadian and Italia stage artists. Multidisciplinary and practical approaches come together in a perspective that observes the theatre first and foremost from an aesthetic angle. The results, presented via international conferences, lectures and publications, will be disseminated in the EU and CANADA, thanks to the support of the respective host institutions UMIL and UQAM, and will be decisive for the experienced researcher’s career development in the academic field.

Keywords: philosophy,theatre,aesthetics,cultural appropriation,identity politics
You will never drive alone (SHERPA-CAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 2049312.5
EU funding (EUR): 1434518.75
Participants: 1
Project status: CLOSED

The automotive sector is in a moment of industrial revolution derived from the technological immersion in which it finds itself. In this new era, the chassis takes a back seat, and the technology and infotainment systems of the automobile gain strength as a means of optimizing the user experience. SHERPA, the predictive personal assistant based on powerful artificial intelligence algorithms will make the experience in your car unique, more enjoyable, safer and more productive. SHERPA was founded in 2012 in Bilbao (Spain) by Xabi Uribe-Etxebarria, who after years of knowledge and ample experience in the world of Virtual Personal Assistants (VPA) and Natural Language Processing (NLP) decided to start SHERPA and build a team composed by highly qualified members, fundamentally engineers and Doctors in Artificial Intelligence (AI). In its short period of life, SHERPA app has become the Spanish-speaking leader in personal assistants hosting one of the most powerful machine learning systems for predicting information, competing directly with those developed by tech giants such as Google, Apple or Microsoft. Furthermore, SHERPA has raised the largest round of seed funding (Series A round) of the year in 2016 in Spain (5.8 M €) to develop vertical solutions such as SHERPA-CAR. This project aims to enter the global automotive infotainment market (expected USD 37.62 billion by 2025), with a business of cumulative 29.7 M € EBITDA in five years and 240% CAGR. Proof of its success is the distribution agreement with SAMSUNG in May 2015 to pre-install the latest version of the SHERPA app on Samsung Galaxy S6 y S7 smartphones and Samsung Galaxy S6 edge handsets. Due to its remarkable achievements, SHERPA has been recognized worldwide with international awards and has received great recognition from high-tech figures such as former Apple’s co-founder, Steve Wozniak, and from leading technology advisory firms such as Gartner, which has frequently included SHERPA in its special reports

Keywords: connected car,infotainment system,virtual personal assistant
Hydrogen isotopes in plant-derived organic compounds as new tool to identify changes in the carbon metabolism of plants and ecosystems during the anthropocene (HYDROCARB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-11-01
End date: 2023-10-31
Duration (months): 72.0
Total project cost (EUR): 1999941.0
EU funding (EUR): 1999941.0
Participants: 1
Project status: SIGNED

HYDROCARB is motivated by the enormous potential that stable hydrogen isotope ratios (δ2H values) in plant compounds have as hydrological proxy, but in particular as new proxy for the carbon metabolism in plants. Current conceptual models suggest that δ2H values in plant organic compounds are composed of (i) hydrological and (ii) metabolic signals. The hydrological information that is contained in δ2H values of plant material is now well understood and is often applied in (paleo-) hydrological research. In contrast, the metabolic information that is contained in plant δ2H values is mostly unknown. Intriguing recent research suggests, however, that metabolic signals in the δ2H values of plant organic compounds reflect the balance of autotrophic and heterotrophic processes in plants. This suggests that exciting and previously unknown opportunities exist to exploit δ2H values in plant compounds for information on the carbohydrate metabolism of plants, which would be relevant for a broad range of biological and biogeochemical disciplines. The goal of HYDROCARB is to perform the experimental work that is now needed to identify the key biochemical and physiological processes that determine the metabolic information that is recorded in the δ2H values of plant organic compounds such as leaf wax lipids, lignin and cellulose. With this HYDROCARB will provide the basis for semi-mechanistic models that will allow (i) disentangling hydrological from metabolic signals in plant δ2H values and (ii) identifying the precise physiological processes with respect to a plants carbohydrate metabolism that can be deducted from the δ2H values of different plant compounds. If successful, HYDROCARB will establish with this research δ2H values in plant organic compounds as a powerful new proxy that will allow ground-breaking and innovative research on plant and ecosystem carbon cycling, which has implications for plant biology, biogeochemistry and the earth system sciences.

Keywords: stable isotopes
Impact of invasive alien true bug species in native tropich webs (INVASIoN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Italy,Greece,France,United Kingdom,Canada
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 252000.0
EU funding (EUR): 238500.0
Participants: 7
Project status: CLOSED

Insects can be accidentally introduced into non-native ecosystems by humans, or expand their geographical range toward the poles as a consequence of global warming. As they invade new environments, exotic species interact with local species, modifying the structure of local food webs. New associations arising from with biological invasions can impact the strength of existing links with effects cascading through trophic levels. When invasive species are herbivores that can attack economically important crops, they can cause serious economic losses. For example, recent invasion of the brown marmorated stink bug (BMSB) (Halyomorpha halys) in Europe and North America has the potential to interfere with local trophic webs and poses a serious threat to several agro-ecosystems. In this project, we will adopt a multidisciplinary approach to study the ecological consequences of BMSB invasions. In particular, we will focus on the effect of alien herbivore invasion on local natural enemies using the following work packages: 1) the impact of exotic herbivores on infochemical communication between plants, herbivores and natural enemies; 2) Learned responses of parasitoids to infochemical evolutionary traps in a climate change context; 3) Contest behaviour of local egg parasitoids for possession of co-evolved and non-coevolved hosts; 4) Patch time allocation of local egg parasitoids after alien herbivore invasion: behavioural and modelling approaches; 5) Molecular aspects of indirect plant defences against invasive and local species 6) Genetic structure of invasive alien herbivores across Europe and North America The proposed research will be of great relevance for the RISE call as it will be an unparalleled opportunity for complementary European and Canadian research groups to join forces, resulting in the development of lasting research collaborations, the transfer of knowledge between research institutions and improving research potential at the European and global levels.

Keywords: indirect plant defense,semiochemicals,insect parasitoids,exotic herbivore insects