Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Artificial Intelligence Roadmap for Policing and Law Enforcement (ALIGNER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Coordination and support actions
Countries involved: Germany,Spain,Belgium,Sweden,United Kingdom
Call: Developing a research roadmap regarding Artificial Intelligence in support of Law Enforcement (H2020-SU-AI-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 1499960.0
EU funding (EUR): 1499960.0
Participants: 7
Project status: SIGNED

ALIGNER aims to bring together European actors concerned with Artificial Intelligence, Law Enforcement, and Policing to collectively identify and discuss needs for paving the way for a more secure Europe in which Artificial Intelligence supports LEAs while simultaneously empowering, benefit-ing, and protecting the public. To achieve this, ALIGNER will (1) Facilitate communication and cooperation between actors from law enforcement, policing, policy-making, research, industry, and civil society about the changing dynamics of crime patterns relevant to the use of AI by establishing a workshop series; (2) Identify the capability enhancement needs of European LEAs; (3) Identify, assess, and validate AI technologies with potential for LEA capability enhancement by implementing a technology watch process that includes impact and risk assessments; (4) Identify ethical, societal, and legal implications of the use of AI in law enforcement; (5) Identify means and methods for preventing the criminal use of AI via the development of a taxonomy of AI-supported crime; (6) Identify policy and research needs related to the use of AI in law enforcement by mapping practitioner needs and emerging crime patterns with identified AI technologies; and (7) Employ the gathered insights in order to incrementally develop and maintain an AI research roadmap. ALIGNER ensure that project results are applicable and relevant by not only including three LEA organisations as full partners of the project, but also establishing two external advisory boards, one for LEA practitioners and one for researchers, industry professionals, ethicists, and civil society. The members of these boards will build the core stakeholders participating at ALIGNER workshops.

Keywords: ethics assessment,legal assessment,societal impact assessment,technology risk assessment,technology impact assessment,stakeholder engagement
Challenges on the road to genome duplication: Single-molecule approaches to study replisome collisions (REPLISOMEBYPASS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Faithful duplication and transmission of genetic and epigenetic information is the most vital cellular function for the preservation and proliferation of life. In cells, this process is conducted by large macromolecular complexes, known as replisomes, that coordinate the sequence of enzymatic events during chromosome duplication. While recently developed single-molecule techniques promise unprecedented access to the complex inner workings of these sophisticated machines, most studies conducted have focused on individual factors, operating on non-physiological substrates, which has provided an incomplete molecular picture. My recent development of a multidimensional, single-molecule imaging approach that allows for real-time visualisation of coordination during replication represents a significant breakthrough in our ability to study macromolecular machines in vitro. Building on this success, here I describe single-molecule imaging approaches to address one of the long-standing questions in chromosome biology: How do replisomes maintain efficiency and coordination during collisions with obstacles on the chromosome? Our objective is to develop a complete molecular understanding of the consequences of replisome collisions and the underlying mechanisms that allow for bypass or trigger replication fork collapse. We will begin this long-term research effort by addressing several issues fundamental to chromosome replication: How does replisome coordination and composition change during encounters with topological barriers in chromosomes? What are the dynamic events that underlie nucleosome disassembly by histone chaperones during replication? How does the eukaryotic replisome collaborate with histone chaperones to ensure faithful inheritance of epigenetic information encoded on histones? These studies will provide a framework for understanding the dynamics of replisome collisions and the molecular origin of chromosome damage underlying many diseases.
MIcrovascularizED Tumour-on-chip for Cellular ImagiNg of Drug Response and Cell moTility (MImETIC INDiRECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

MImETIC INDiRECT aims to develop a standardised, accessible, versatile organ-on-chip toolkit for cancer biology and drug discovery research, compatible with microscopy-based (live imaging and confocal) techniques. The project is expected to facilitate academia and industry adoption of microfluidic 3D cell culture systems for comparable and reproducible results in a complex biomimetic animal free model for cancer drug discovery, toxicology, advanced (pre)clinical as well as personalized medicine. The toolkit components will consist of an integrated temperature controller dual-chamber chip, the Cherry Biotech CubiX system and growth factor optimized collagenous solutions for each chip chamber. The dual chamber chip, with cellular migration lanes, will have two tailored collagen-based formulations, designed per chamber. The CubiX platform is a compact flow and temperature controller, allowing optional sensor (e.g. O2) integration, compatible with single chips or 24-well plates. The cancer(s) sub-types to be used toolkit standardization will be dictated by market needs, where commercial cell lines (cancerous and non-cancerous) will be used to create the microvascularized complex tissue model. Potential project risks have been identified with appropriate mitigation strategies, where the project promotes adoption of standardized, cost-effective and versatile cancer organ-on-chip platforms in the market, rather than disruptive academic findings. Access of the aforementioned system to a worldwide growth market will fully exploit the project results, disseminated by direct and indirect marketing and scientific approaches. Project implementation will be an academic-industry collaborative and multidisciplinary manner providing the acquisition of diverse and unconventional complementary skills, leading to an understanding of both sectors requirements. We envision the above-mentioned to facilitate future academic and industry collaborations.

Keywords: microfluidics,organs on chip,biomaterial hydrogels,cancer biology,drug discovery,cell motility
Project on Exercise for Fatigue Eradication in Advanced Breast cancer to improve quality of life (PREFERABLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Australia,Germany,Germany,Spain,Poland,Sweden,Netherlands,Netherlands
Call: Novel patient-centred approaches for survivorship, palliation and/or end-of-life care (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 4121130.0
EU funding (EUR): 3983347.0
Participants: 12
Project status: SIGNED

Despite the tremendous improvement in early diagnosis and treatment of breast cancer, a large proportion (up to 40%) of patients with breast cancer will eventually develop metastases. Patients with metastatic breast cancer (MBC) have a median overall survival of 2-3 years, and a relative 5-year survival of 34%. Current advances in therapy have extended the life of those patients with MBC, however these patients still suffer (for longer periods) from deleterious side-effects (either related to the disease itself or to the treatment) such as fatigue, pain, nausea and vomiting, insomnia, dyspnoea, emotional, social and cognitive dysfunction. Among all these side-effects, fatigue is the most common and distressing treatment-related side-effect, as up to 90% of patients with MBC experience fatigue over the course of treatment. All these symptoms negatively affect patients’ QoL and thus an urgent solution is needed to help those with advanced breast cancer to “live well” for as long as possible. PREFERABLE’s vision is to improve the standard of care in MBC by improving the quality, effectiveness and cost-effectiveness for patients in a palliative setting using a non-pharmacological intervention combining supervised and unsupervised app-based exercise. Based on the results from a multinational randomised controlled phase 3 clinical trial (EFFECT trial; (cost)- effectiveness study), the different perspectives of patients with MBC on exercising (PERSPECTIVE study), and through mapping the differences in the European healthcare systems, the PREFERABLE project will generate solid and conclusive evidence of the beneficial effect of exercise on cancer-related side effects and patients’ quality of life in the palliative setting. By this, PREFERABLE will contribute towards reshaping medical practice and improving clinical guidelines and recommendations.

Keywords: exercise intervention,fatigue,palliative care,supportive care,metastatic breast cancer
Budapest Smart City Centre of Excellence (smartpolis)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Hungary
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 388688.0
EU funding (EUR): 388688.0
Participants: 4
Project status: CLOSED

The primary objective of the proposed project is to prepare the establishment of the Budapest Centre of Excellence for Smart Cities built on the innovation capacity, know-how and expertise of the project partners. The new organization, SMARTPOLIS, should contribute with knowledge creation, knowledge transfer, as well as with research, innovation and deployment projects in the Central-Eastern- European region to reach the European goals defined by Horizon 2020. The consortia organized for this proposal will be strengthening the research and innovation capabilities of the Budapest University of Technology and Economics (BME), the operator of the new Centre, in this promising multidisciplinary scientific and technological field. The coordinator of the project the Hungarian Intellectual Property Office, a Government Agency, plays a very active role in Hungary as well as in the broader region in respect of innovation management and the facilitation of communication and cooperation between industry and academia. The advanced, highly reputable European partners, Fraunhofer FOKUS (FFI) and the Urban Software Institute, are forming a consortium for their cooperation in this project. They contribute organisatory and operational know-how, technical and scientific knowledge as well as project and implementation expertise which will be the foundation of the new Centre. The accomplishment of the short term goals, elaboration of the operating principles and associated business model of the new Centre, will be the target of this first phase of the TEAMING project. The work plan of the initial 12 months will comprise: • Status assessment • Forecasting future trends • Elaboration of the operating concept of the Centre, including its scientific program and administrative model • Development of the business model of the Centre for the initial 5 year period • Establishment and implementation of a proper framework for communication

Keywords: smart cities,knowledge transfer,innovation,centre of excellence,regional scope,best practice,quality of life,sustainability,emission control,mobility,ict technologies
Land-Based Solutions for Plastics in the Sea (LABPLAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Germany,Germany,Spain,Spain,Belgium,France,Netherlands,Netherlands,Netherlands,Brazil,United Kingdom,United Kingdom,Portugal,Portugal
Call: Plastics in the environment: understanding the sources, transport, distribution and impacts of plastics pollution (H2020-SC5-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 5039333.75
EU funding (EUR): 5011111.0
Participants: 19
Project status: SIGNED

There are 5,250 billion plastic particles floating on the surface on the world's seas and oceans, equivalent to 268,940 metric tons of waste. These fragments move with the currents before washing up on beaches, islands, coral atolls or one of the five great ocean gyres. Because MP cannot be removed form oceans, proactive action regarding research on plastic alternatives and strategies to prevent plastic entering the environment should be taken promptly. Despite the research increasing, there is still a lack of suitable and validated analytical methods for detection and quantification of small micro- and nano plastics (SMNP) evidencing a huge obstacle for large-scale monitoring. There is also a lack of hazard and fate data which would allow their risk assessment. LABPLAS is a 48-months project whose vision is creating capacities (sampling, analysis and quantification techniques, new materials and new models) to evaluate rapidly and precisely the interactions of plastics with the environmental compartments and natural cycles leading to the development of effective mitigation and elimination measures, as well as, making management decisions. It will assess reliable identification methods for more accurate assessment of the abundance, distribution and toxicity determination of SMNP in the environment, giving the opportunity of new developments of cutting edge technologies. It will also develop practical computational tools that up-scaled should allow European agencies to map plastic-impacted hotspots. The project will have a multi-actor approach, creating scientific knowledge with a partnership of scientists, technicians, research organizations and enterprises, working together towards the recognition at different levels (society, industry, policy) of the main issues (sources, potential biodegradability, ecotoxicology, ingestion, environmental assessment) related to the presence of plastics in ecosystems.

Keywords: freshwater environment,marine environment,microplastic,nanoplastic,modelling,plastic dispersion,plastica transport
Increasing in vitro fertilization success rate by turning embryo analysis from qualitative to quantitative (Embryospin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland,Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-02-01
End date: 2023-03-31
Duration (months): 26.0
Total project cost (EUR): 2302410.0
EU funding (EUR): 1611687.0
Participants: 2
Project status: CLOSED

EmbryoSpin is a proprietary sensor for μNMR, capable to increase the sensitivity by an order of magnitude (10x) with respect to the state-of-the-art, thus allowing the analysis of cells and materials from a completely new viewpoint. Among the host of applications for this technology, the introduction of EmbryoSpin as a fast and effective embryo selection tool during In Vitro Fertilization (IVF) treatments has proven to represent a huge business opportunity. In fact, in more than 1.69 million IVF procedures performed globally each year, embryologists adopt visual inspection to select the embryo that has most chances to be successfully implanted to the uterus, often leading to long time to pregnancy due the selection of the wrong embryo and repeated fertilization cycles. With Embryospin, embryo’s metabolic activity is measured through μNMR and is used as a reliable quantitative marker of embryo’s vitality, thus increasing the chance of pregnancy after a single treatment cycle. This is valuable for women that undergoes less fertilization cycles, and to the clinics that can enhance the number of IVF performed each year. EmbryoSpin equipment and disposable μNMR sensors will serve up to 3,500 IVF treatments, generating 33 M€ of revenues by 2025.

Keywords: embryo assessment,nuclear magnetic resonance
Mid Infra-Red near-field control by Adiabatic frequency Generation Enabling 20fs/15nm resolution (MIRAGE 20-15)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 1493250.0
EU funding (EUR): 1493250.0
Participants: 1
Project status: CLOSED

The goal of this proposal is to allow observing and controlling ultrafast phenomena in a spatio-temporal window of 20fs-15nm at mid-IR by merging the extreme temporal resolution of the recently developed single-cycle mid-IR pulses with the spatial resolution of near field scattering optical microscope (aSNOM). The mid-infrared wavelength regime is of particular importance to materials science, chemistry, biology and condensed matter physics, as it covers the fundamental vibrational absorption bands of many gaseous molecules and bio-molecules. Adiabatic frequency conversion, a recent advance in nonlinear optics based on my PhD research and my current collaboration with MIT, generates ultrashort pulses in this important wavelength regime, which outperform the currently available mid-IR ultrashort sources, and unlike other techniques allows complete control of the temporal evolution by amplitude and phase manipulation of the NIR input. Combining these capabilities with aSNOM will allow one-of-a-kind route to perform active coherent control of quantum dynamics and allow single shot spatio-temporal observation of fast dynamical processes at nanoscale-resolution. Moreover, mid-IR ultrashort pulses delivered to the nanoscale can produce the high peak power needed to observe the nonlinear properties of the material under examination. Together with the richness of pulse shape manipulation it stands to enable, the currently impossible capability of intra-pulse multidimensional mid-IR spectroscopies at the nanoscale. This will open a gateway to all-optical, non-intrusive and label-free in situ studies of ultrafast processes in 2D materials and topological insulators, peptide evolution, photo-induced surface femtochemistry and protein folding. In particular, I plan to utilize these capabilities to explore nanoscale surface femtochemistry and to study energy pathways of hot carriers following the plasmonic decay in 2D materials and plasmonic nanostructures.

Keywords: femto chemistry,nonlinear optics,ultrafast physics,pulse shaping
Enhanced Physical Internet-Compatible Earth-frieNdly freight Transportation answER (ePIcenter)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Spain,Germany,Germany,Spain,Lithuania,Poland,China,Colombia,Switzerland,Belgium,Belgium,Finland,Poland,Sweden,Sweden,Latvia,Netherlands,United States,United Kingdom,Canada,Montenegro,United Kingdom,Portugal
Call: InCo Flagship on Integrated multimodal, low-emission freight transport systems and logistics (H2020-MG-2019-TwoStages, 2019)
Start date: 2020-06-01
End date: 2024-05-31
Duration (months): 48.0
Total project cost (EUR): 7373575.0
EU funding (EUR): 6848575.0
Participants: 41
Project status: SIGNED

ePIcenter will create an interoperable cloud-based ecosystem of user-friendly extensible Artificial Intelligence-based logistics software solutions and supporting methodologies that will enable all players in global trade and international authorities to co-operate with ports, logistics companies and shippers, and to react in an agile way to volatile political and market changes and to major climate shifts impacting traditional freight routes. This will address the ever-increasing expectations of 21st century consumers for cheaper and more readily available goods and bring in Innovations in transport, such as hyperloops, autonomous/robotic systems (e.g. “T-pods”) and new last-mile solutions as well as technological initiatives such as blockchain, increased digitalisation, single windows, EGNOS positional precision and the Copernicus Earth Observation Programme. ePIcenter thus addresses MG-2-9-2019 of H2020 Mobility for Growth “InCo Flagship on Integrated multimodal, low-emission freight transport systems and logistics”, particularly in what refers to new logistics concepts, new disruptive technologies, new trade routes (including arctic routes and new Silk routes) and multimodal transfer zones. ePIcenter will speed up the path to a Physical Internet and will benefit peripheral regions and landlocked developing countries. ePIcenter will reduce fuel usage (and corresponding emissions) by 10-25%, lead to greater utilisation of greener modes of transport reducing long distance movements by trucks by 20-25% and ensure a smoother profile of arrivals at ports which will reduce congestion and waiting/turnaround times.

Keywords: intermodal logistics,synchromodality,physical internet,arctic,silk road,belt and road initiative,hyperloop,autonomous vehicles,marine wildlife,environment,artificial intelligence