Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Heat Shock Protein 70 in the regulation of plant cell wall function (PLANT CELL WALL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Plants respond to diverse signals by substantial changes in their morphogenetic plan. Changes in cell shape and size require remodeling of the existing plant cell wall to allow turgor-driven growth to occur. An important question is how plant cell wall remodeling is regulated to accommodate to a changing environment. In our preliminary results, HEAT SHOCK PROTIEN 70-1 (HSP70-1) was identified as novel regulator of cell wall function. Three semi-dominant hsp70-1shou5 alleles were identified as suppressors in fei1fei2 background. The FEI receptor-like kinases regulate cellulose biosynthesis in root tips, etiolated seedlings and seed coat mucilage. HSP70s act as ATPase-dependent chaperones and have diverse functions during plant growth and development and in plant response to different environmental signals. In the proposed research, we will further characterize the effect of the hsp70-1shou5 mutations on cell wall composition and the mechanism of cellulose biosynthesis. The effect of hsp70-1shou5 on plant transcriptome and metabolome will be studied in different developmental contexts (i.e. elongating roots and seed coat). Genetic interactions between hsp70-1shou5 and other cellulose related mutants will be examined. Downstream targets of HSP70-1 will be identified by EMS-induced mutagenesis of fei1fei2hsp70-1shou5 screened for enhancers and suppressors and by yeast two-hybrid screen for HSP70-1 interacting proteins. For a subset of candidate genes identified, their effect on HSP70 activity and cell wall function will be studied. In the proposed research we utilize the hsp70-1shou5 alleles to overcome functional redundancy and assign a new role for HSP70 in the regulation of cell wall remodeling and plant adaptation to changing environment. Improved understanding of the mechanism employed in cell wall remodeling will set the stage for the development of biotechnological tools aimed at the modification of industrial and agricultural traits-of-interest.

Keywords: plant,cell wall,heat shock protein 70,hsp70,cellulose,adaptation to changing environment
Magnetic Particle Imaging for Safe Angiography (MPI-ANGIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Magnetic Particle Imaging (MPI) is a new imaging modality with the ideal image contrast for angiography that uses completely different hardware from X-ray, CT, or MRI. MPI is now at an exciting stage of development similar to where MRI was in the early 1980s. Currently, there are no commercially available MPI scanners. Only a handful of prototype small animal MPI scanners have been constructed worldwide in research environments. Yet, there is already great promise for diagnostic application of MPI for the three top mortality diseases in the world: cardiovascular disease (25% of all deaths), cancer (23%), and stroke (5%). MPI angiography shows great promise as a noninvasive, non-ionizing replacement for the millions of high-risk iodinated contrast studies performed annually. The contrast agent used in MPI, Super-Paramagnetic Iron Oxide (SPIO) nanoparticles, has been found to be extremely safe, even for chronic kidney disease (CKD) patients whose kidneys cannot safely excrete iodine contrast agents of X-ray and CT angiography. Indeed, SPIOs are now EU approved to treat anemia in CKD patients. With this proposal, Dr. Saritas will begin development of Turkey’s first MPI laboratory, and transfer her MPI expertise acquired at University of California, Berkeley to the scientific community in Europe. MPI-ANGIO project proposes several innovations in MPI hardware, contrast agent and pulse sequences to improve MPI’s spatial and temporal resolutions, now ~2 mm pixels and 7-minute scan time, to a much sharper 300-micron resolution at 2-4 frames/second.

Keywords: medical imaging,magnetic particle imaging,mpi,safe contrast,contrast agent,super paramagnetic iron oxide,spio,magnetic nanoparticles,angiography,cancer imaging
Neural bases of visually guided walking in the fly (SENSORIMOTORFLY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Knowing how to get to a food source, approximate towards conspecifics or avoid a predator, are orientation behaviours with remarkable consequence for the success of an individual and the fitness of the species. They all depend on the brain’s ability to process sensory stimuli and integrate this with ongoing behaviour to generate spatial information that guides actions. Although much is known about how sensory neurons process incoming stimuli, or how motor neurons generate movements, it remains unclear how other neurons in our brains represent more integrative processes that lead to the transformation of sensation into action. For visual animals, visually guided locomotion is an ethologically relevant behaviour that is easy to reproduce in a laboratory environment, and depends on the integration of visual motion signals with ongoing locomotion. Through the identification of interconnected neurons, and analysis of their activity patterns in simultaneous with quantitative measurements of visually guided locomotion, we aim to determine the functional organization of visuomotor circuits essential to orientation behaviours. In particular, we would like to understand how self-generated motion vision provides information to guide the animal’s orientation behaviours. To transcend the experimental limitations found in mammalian model systems, such as the numerical complexity of their brains, or the more limited resources available to systematically identify and perturb neurons of a circuit, we employ the fruitfly, Drosophila melanogaster, as our model organism. Her rich repertoire of visually guided behaviours combined with her unparalleled arsenal of genetic tools, and with head-fixed physiology in behaving animals, provide an ideal platform for a multilevel research program to study the neural bases of orientation behaviours while establishing conserved principles of sensory-motor processing.

Keywords: neural circuits,motion vision,sensorimotor integration,neural tracing,functional connectivity,optical imaging,electrophysiology,behavior,drosophila melanogaster
New Light on Chemical Dynamics (NEWLIGHT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

New theory and computational methods are crucial to unlock the full potential of new ultrafast experiment soon to be made possible by light sources currently under construction, such as the European XFEL in Hamburg and the LCLS in Stanford. This proposal focuses on ultrafast diffraction imaging, either by x-rays or electrons, and a new intense-laser technique, high harmonic spectroscopy. The distinct advantage of diffraction based techniques is that they allow a direct interpretation of molecular dynamics in terms of the motion of atoms, while the high harmonic spectroscopy is spectacularly sensitive to the electronic changes that accompany chemical transformations and which often govern the outcome of photochemical reactions. In short, these two sets of techniques have the potential to revolutionize our ability to observe and control photochemistry and ultrafast dynamics, but the theoretical tools to interpret them are missing. I will develop these tools and significantly advance the state-of-the-art in quantum simulations by making realistic start-to-finish simulations of the experiments possible. This can only be achieved by adapting cutting-edge techniques from atomic, molecular and optical physics.

Keywords: theoretical and computational chemistry,chemical physics,photochemistry,spectroscopic and spectrometric techniques,reaction mechanisms and dynamics
Pathways between Children’s Behavior problems and Parental Stress and Parenting among Parents of Children with Autism Spectrum Disorders (PARENTING STRESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-02-01
End date: 2018-01-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Children with Autism Spectrum Disorders (ASD) experience a complex range of social, emotional, and behavioural difficulties that present significant, ongoing concerns for parents. A well-accepted sequel of children's ASD is increased parenting stress. Despite consistent evidence demonstrating significant ongoing associations between behavioural difficulties among children with ASD and parenting stress, few studies have examined potential underlying processes that link children’s behaviour problems to parenting stress. Several longitudinal studies have demonstrated a bidirectional relationship between child behaviour problems and parenting stress and well-being. However, over and above the caregiving demands placed on parents of children with ASD, little is known about parenting behaviours of parents of children with ASD, let alone whether they are impacted by parenting stress. The first Study of the proposed project will examine the mediating role of mothers' cognitions regarding their parenting and mothers’ executive function abilities between child behaviour problems and parenting stress. The second will investigate the relations between parental stress, parenting negativity, and parent-child interaction among mothers of children with ASD in comparison to mothers of typically developing children. In addition, it will examine whether child behaviour problems moderate these relations; and the link between parenting stress and parental involvement among mothers of children with ASD

Keywords: behavior problems,parental stress,parenting,parental cognitions,executive function,parent-child interaction autism spectrum disorders
Individualized Implant Placement (IIP)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Germany
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-01-01
End date: 2014-12-31
Duration (months): 12.0
Total project cost (EUR): 168224.4
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The goal of the Proof of Concept (PoC) project is a licensing software (e.g. within a spin-off) that provides a framework to compute a suited (individualized) implant placement for patients: E.g. for hip or knee replacements, during an operation planning phase, a surgeon selects an implant and determines its placement and possible motion range. Since humans are highly individual, factors such as gender, age, height or weight, among many other parameters influence the implant type and placement. Indeed the implant placement is always sub-optimal as the decision is solely based on the surgeons experience. A wrong placement can reduce the quality of life of the patient after the operation. Our software will close this gap and provide surgeons with the required key-information to make a high accurate individualized surgery planning: Our method will exploit statistical information about human shape and motion to extract this information. The software needs to be fast and accurate and must allow to take into account semantic meta information about the patient, e.g. by exploiting information such as gender, weight, height, age, etc. Based on our knowledge from the ERC starting Grant Dynamic MinVIP, this can be done in a statistical setting by training a PCA-model and by linear regression on the semantic parameters. Whereas our concept focuses on knee and hip treatment, it should be emphasized, that the concept is very general and has similar applications for e.g. hearing aids, aesthetic surgeries (e.g. breast cancer or burn patients), face/limb reconstruction or for the design of other orthopaedic devices, such as thrombosis stockings. We further expect insights which will help surgeons and engineers for the design of implants, which again will be of major importance for a company.

Keywords: 277729
MAssive MiMO for Efficient Transmission (MAMMOET)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trusted Network and Service Infrastructures
Action type: Collaborative project
Countries involved: Austria,Belgium,Sweden,Sweden,Sweden,Spain
Call:  (FP7-ICT-2013-11, 2013)
Start date: 2014-01-01
End date: 2016-12-31
Duration (months): 36.0
Total project cost (EUR): 4384904.0
EU funding (EUR): 3047000.0
Participants: 8
Project status: CLOSED

The Internet of the future will to a large extent rely on mobile networks. Mobile data grew with 70% in 2012 and is predicted to grow 13-fold in the next 5 years. This puts very high demands on the development of mobile access technology. MAMMOET will advance the development of Massive MIMO (MaMi), a new and most promising direction in mobile access. MaMi makes a clean break with current technology by using several hundreds of base station antennas that operate phase-coherently together, simultaneously serving many tens of low-complexity single-antenna terminals in the same time-frequency resource.MAMMOET will demonstrate that MaMi can increase both data rates and the overall spectral efficiency by up to ten times, while decreasing the transmitted radiofrequency (RF) power by many orders of magnitude. Other benefits of MaMi include the extensive use of inexpensive low-power components, reduced latency, simplification of the multiple-access layer, and robustness to interference. The drastically reduced emitted RF power can reduce the total energy consumption of a mobile network, when implemented with simple, low power hardware developed in MAMMOET. Consequently, MaMi can, with proper system design, facilitate entirely new deployment scenarios, with wind or solar powered base stations. MAMMOET will substantially contribute to the development of practical MaMi systems and secure a leading position for European industry in its exploitation. Specifically, MAMMOET will investigate the practical limitations of MaMi, and develop complete technological solutions leveraging on innovative low-cost and drastically more efficient and flexible hardware.The academic and research institute partners in MAMMOET include pioneers in MaMi and groups with extensive experience in circuit design for wireless communications. The industrial partners are leaders in their fields and cover the entire chain from component manufacturing to system development and service provisioning.

Keywords: mobile access,mobile broadband,wireless communications,multiple antennas,mimo,rf hardware,baseband signal processing,energy efficient communications
Demonstrating Managed Aquifer Recharge as a Solution to Water Scarcity and Drought (MARSOL)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Improving resource efficiency
Action type: Collaborative project
Countries involved: Germany,Greece,Portugal,Spain,Italy,Germany,Germany,Portugal,Israel,Malta,Spain
Call:  (FP7-ENV-2013-WATER-INNO-DEMO, 2013)
Start date: 2013-12-01
End date: 2016-11-30
Duration (months): 36.0
Total project cost (EUR): 8022150.55
EU funding (EUR): 5176078.0
Participants: 23
Project status: CLOSED

Southern Europe and the Mediterranean region are facing the challenge of managing its water resources under conditions of increasing scarcity and concerns about water quality. Already, the availability of fresh water in sufficient quality and quantity is one of the major factors limiting socio economic development. Innovative water management strategies such as the storage of reclaimed water or excess water from different sources in Managed Aquifer Recharge (MAR) schemes can greatly increase water availability and therefore improve water security. Main objective of the proposed project MARSOL is to demonstrate that MAR is a sound, safe and sustainable strategy that can be applied with great confidence and therefore offering a key approach for tackling water scarcity in Southern Europe. For this, eight field sites were selected that will demonstrate the applicability of MAR using various water sources, ranging from treated wastewater to desalinated seawater, and a variety of technical solutions. Targets are the alleviation of the effect of climate change on water resources, the mitigation of droughts, to countermeasure temporal and spatial misfit of water availability, to sustain agricultural water supply and rural socio-economic development, to combat agricultural related pollutants, to sustain future urban and industrial water supply and to limit seawater intrusion in coastal aquifers. Results of the demontration sites will be used to develop guidelines for MAR site selection, technical realization, monitoring strategies, and modeling approaches, to offer stakeholders a comprehensive, state of the art and proven toolbox for MAR implementation. Further, the economic and legal aspects of MAR will be analyzed to enable and accelerate market penetration. The MARSOL consortium combines the expertise of consultancies, water suppliers, research institutions, and public authorities, ensuring high practical relevance and market intimacy.

Keywords: water resources management,improving water availabilty,water scarcity,drought mitigation,water technology,artificial groundwater recharge,managed aquifer recharge,mediterranean
Integrated Reconfigurable silicon photonic based optical Switch (IRIS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Alternative Paths to Components and Systems
Action type: Collaborative project
Countries involved: Italy,France,Austria,Spain,Korea, Republic of
Call:  (FP7-ICT-2013-11, 2013)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 5631000.0
EU funding (EUR): 3350000.0
Participants: 8
Project status: CLOSED

IRIS aims at fabricating a highly integrated, scalable, transparent and high capacity WDM Photonic Switch used as an Transponder Aggregator (TPA),a novel function which will be added to existing ROADM nodes without disrupting their architecture while adding attributes such as colourless, directionless and contentionless. For Metro networks, this switch will provide flexibility, energy efficiency, very small footprint,low cost and faster reconfigurability (microsecond regime) as they are particularly required in this segment of the network and, in conjunction with an intelligent control and management plane, it will empower future software defined networking (SDN).This novel integrated switch architecture is also suitable for Data Center networking due to its capability to manage large throughput in a single chip with low cost, low footprint and low power consumption.The new TPA will be based on a fully integrated electro-photonic device realized by using Silicon Photonics with an unprecedented density of photonic components (>1k on <30 mm2 chip area) controlled by >2k electronic building blocks. The TPA target product is an optical sub-system for Metro applications driving 48 optical channels, with 100 GHz spacing in the C-band, 4 different directions and 12 add/drop channels. A fully packaged prototype will be implemented with 12 wavelengths, 4 directions and 8 A/D ports, it will be integrated with a commercial transport node and tested with 10G and 100G signals. The TPA proposed has the competitive advantage, with respect to existing solutions, of more than an order of magnitude lower cost (few hundreds $) and overall device volume a factor of 60 smaller (only a few cubic centimetres). IRIS is strongly oriented toward industrialization as it is led by a major European telecom equipment manufacturer (Ericsson) and participated by a major European Silicon manufacturing company (STMicroelectronics), already committed to the industrialization of Silicon Photonics.

Keywords: wdm networks,optical networks,silicon photonics,photonic integration,transponder aggregator,cdc roadm,large scale pic,optical metro transport networks,optical networks for data centers