Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Realizing designer quantum matter in van der Waals heterostructures (GETREAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Finland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2498623.0
EU funding (EUR): 2498623.0
Participants: 1
Project status: SIGNED

Conventional materials hosting exotic quantum phases typically have complex atomic structures, inhomogeneities from defects, impurities, and dopants making it difficult to rationally engineer their electronic properties. This can be overcome using van der Waals (vdW) heterostructures that allow an almost arbitrary selection of the heterostructure building blocks, including metals and insulators, charge-density wave systems, superconductors, magnets, correlated insulators, and ferroelectrics. In a vdW heterostructure, the layers interact only through vdW forces and can keep their intrinsic properties. However, proximity effects cause properties to “leak” between the adjacent layers and allow creating exotic quantum mechanical phases that arise from the interactions between the layers. These key features have recently made it possible to realize exotic quantum phases by design and engineer responses that do not occur in natural materials. I will now exploit these features and fabricate heterostructures using molecular-beam epitaxy (MBE) to target artificial heavy fermion heterostructures realizing unconventional superconductivity, artificial 2D multiferroic materials, and 2D quantum spin liquids. The atomic scale geometry and electronic properties of the resulting heterostructures will be characterized using low-temperature scanning tunnelling microscopy (STM) and spectroscopy (STS). These designer heterostructures will have engineered electronic phenomena with atomically precise structures and controlled interactions. This will lead to exciting new opportunities in fundamental condensed matter physics and subsequently, in quantum devices realizing completely new functionalities. They answer the pressing need for novel quantum materials with tuneable properties to enable completely new types of approaches in quantum technologies. This will keep Europe at the forefront of the second quantum revolution and create yet unimagined future breakthrough technologies.

Keywords: van der waals heterostructures,scanning tunneling microscopy stm,scanning tunneling spectroscopy sts,molecular beam epitaxy mbe,multiferroic heterostructures,quantum spin liquids,artificial heavy fermion heterostructures
Designing synthetic regulatory domains to understand gene expression (SYNREG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

How the genome controls precise, cell-type specific gene expression is crucial for cell identity and differentiation. Short cis-regulatory elements, such as enhancers, are distributed in extended regulatory domains surrounding their target gene, which in mammals typically span hundreds of kilobases. Although all evidence indicates that gene regulation is controlled by the combined action of large domains, our current understanding mostly focuses on enhancers. If and how intervening DNA sequences, enhancer order, or spacing within regulatory domains contribute to gene regulation is unknown. The reason for this largely unexplored aspect lies in our limited ability to systematically alter large genomic regions. In this study, we will use recent advances in synthetic biology to overcome this limitation. From synthetic DNA, we will create variants of entire gene regulatory domains and integrate these into mouse embryonic stem cells. We will test synthetic regulatory domain function in tailored gene expression analyses using cell culture, organoid, and in vivo models. By investigating regulatory elements with respect to their surrounding regulatory domain, we will uncover hidden rules of gene regulation. In variant regulatory domains we will systematically assay understudied parameters, such as enhancer spacing, order, or inter-enhancer sequences. We will use single-molecule methods to measure gene expression level; use organoid and in vivo systems to profile cell-type specific changes in expression patterns, and we will use the unique potential of synthetic DNA to understand the fundamental link between DNA sequence and chromatin composition of regulatory domains. With this interdisciplinary approach, we aim to uncover previously hidden layers of genomic information. The insights generated from this work will provide a novel and unique view on the organization of the non-coding genome, with the potential to expand our ability to read and write genomic DNA sequences.

Keywords: gene regulatory landscape,synthetic dna,super enhancer,regulatory domain,enhancer interaction,genome engineering
Golexanolone: A First-in-Class Therapeutic Targeting Neuroinflammatory Mechanisms in Parkinson’s Disease (PD-Golexanolone)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Parkinson’s disease (PD), the second most common neurodegenerative disorder, affects over 10 million people globally, with 1.2 million in Europe. Beyond motor symptoms like tremors and bradykinesia, PD is characterized by debilitating non-motor symptoms such as cognitive impairment, fatigue, and excessive daytime sleepiness, which significantly diminish quality of life. Current treatments, focused primarily on motor symptoms, fail to address these non-motor issues, leaving a critical gap in care. Umecrine Cognition is developing golexanolone, a first-in-class GABA-A receptor-modulating steroid antagonist, to address this unmet need. By selectively targeting neuroinflammation and neurosteroid-induced GABAergic dysregulation, golexanolone reduces non-motor symptoms without the severe side effects associated with traditional therapies. Its dual mechanism, addressing both symptoms and underlying disease processes, positions golexanolone as a novel solution for improving outcomes in PD. This project will advance golexanolone through Phase I/IIa clinical trials to evaluate its safety, tolerability, and efficacy in treating non-motor symptoms like EDS and cognitive impairment. Building on successful clinical outcomes in hepatic encephalopathy and primary biliary cholangitis, this trial will establish golexanolone’s potential for treating PD and strengthen Umecrine Cognition’s position for strategic partnerships and outlicensing. Golexanolone offers transformative benefits for patients, caregivers, and healthcare systems by improving patient independence, reducing caregiver stress, and lowering healthcare costs. By aligning with EU priorities for innovative and sustainable therapies, golexanolone has the potential to redefine PD treatment and improve quality of life for millions worldwide.

Keywords: parkinson s disease,non motor symptoms,gaba a receptors,gamsa,neuroinflammation,cognitive impairment,excessive daytime sleepiness,cns disorders,neurosteroid dysregulation
Understanding resilience of seed dispersal in insular systems to climate change (ECORISC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 170856.96
EU funding (EUR): 170856.96
Participants: 2
Project status: CLOSED

Global biodiversity loss is disproportionately rapid on islands, which despite being hotspots of biodiversity, comprise ~ 80% of world’s species extinctions. The vulnerability of insular ecosystems to global change has been historically related to the introduction of invasive species. Yet, we still lack a quantitative understanding of how other major threats such as climate change will jeopardise, not only species, but pivotal ecosystem functions derived from trophic interactions such as animal-mediated seed dispersal. To date, the scarce data and methodological limitations have entailed a lack of studies on the effect of climate change on seed dispersal in entire island communities. ECORISC implies a major step ahead previous work with its integration of a new global dataset on ~65 insular seed-dispersal networks, alongside methodological approaches from the fields of interaction networks, ecological niche modelling and future climate change projections. The combination of empirical knowledge on the structure and vulnerability of current insular communities with future climate, species extinctions and interaction rewiring simulations will provide an integrated understanding of the resilience of seed dispersal in insular systems to climate change. The main outcome of ECORISC (i.e. the quantification of structural and functional consequences derived from climate-driven biodiversity loss) will provide essential knowledge needed to restore Europe’s ecosystems and biodiversity, one of the main issue mainstreamed in the first Horizon Europe strategic plan. During the course of this project, I will receive essential training by world leading experts of the fields of island ecology, niche modelling and complex systems at three outstanding institutes from the disciplines of Ecology and Physics, thus paving my way towards establishing an independent and distinct research profile in the fields of global change and community ecology.

Keywords: island ecology,global change forecasting,functional traits,ecological modelling,frugivory and seed dispersal
Salvador Technologies OT/ICS Cyber Attack Recovery Platform (SalvadorGuard)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The digital transformation of industries has brought unprecedented opportunities and efficiency to the modern world. However, these technological advancements also bring significant cybersecurity challenges, including ransomware attacks, wiper attacks (disk erasure), physical disk damage, software glitches, and more. The standard approach to industrial cyber recovery, which involves detection, forensics, and restoration, is no longer sufficient to address evolving threats and the crucial need to maintain operational continuity in critical assets. We are at the forefront of a new approach to industrial cyber recovery. We are doing so by introducing a pioneering security technology that bypasses traditional cyber-attack recovery protocols of downtime & forensics. Our method involves creating a protected, bootable backup that enables regaining operations within a 30-second timeframe. We accomplish this by developing our unique Cyber Attack Recovery Platform, which consists of 3 key sub-systems: 1. Bootable Cyber Recovery Unit (CRU); 2. Centralised immutable storage Network Recovery Server (NRS); 3. Security Posture Management (SPM) software.

Keywords: critical infrastructure cybersecurity recovery cyber resilience
Advanced Studies in Transfusion Epidemiology: Using ‘Big Data’ to safeguard the blood supply of the future (ASTUTE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1995048.0
EU funding (EUR): 1995048.0
Participants: 1
Project status: SIGNED

The lifetime risk of receiving a transfusion is almost 20%, meaning that close to 100 million EU citizens will receive a transfusion at some point in their lives. Consequently, the issue of blood transfusion safety—in a wide sense—are highly relevant for population health. It is therefore disconcerting that blood safety is often narrowly defined, focusing almost exclusively on the elimination of known transfusion-transmitted disease, ignoring donor health and failing to consider unconventional pathogens. In this comprehensive research program, proposing a series of Advanced Studies in Transfusion Epidemiology, I will lead research within four distinct work packages, first creating a nationwide vein-to-vein database, with detailed data on blood donors and transfused patients in Sweden between 1968 and 2023, linked to detailed outcomes registers, and then making a version of this database publicly available through anonymization. We will then exploit this database in a series of applied studies divided into three work packages. In the first of these, we will conduct a careful, hypothesis-based investigation where we follow-up a previous publication from my research group, showing possible transfusion transmission of an agent causing intracerebral hemorrhage, seeking to establish the etiology of these hemorrhages, and testing whether it might have been driven by transmission of amyloid β. In the second work package we will perform a series of studies of blood donor health, investigating aspects on donor health behavior, short term risks of donating blood, and the risks of negative intergenerational effects from the iron-depletion suffered by many female blood donors. Lastly, we will perform a comprehensive, phenome-wide study where we search for unknown transfusion-transmitted disease using both traditional epidemiological and state-of-the-art machine learning methods. Together, these tasks have the potential of making important gains for transfusion safety in Europe.

Keywords: blood transfusion
Next-generation AAV vectors for liver-directed gene therapy (AAVolution)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,France,Spain,Germany,Hungary
Call: Emerging Technologies in Cell and Gene therapy (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 4500000.0
EU funding (EUR): 4500000.0
Participants: 10
Project status: SIGNED

Liver-directed gene therapy has undergone significant development in the last two decades. Recombinant adeno-associated vectors (AAV) are the vectors of choice for liver gene transfer and have recently achieved remarkable successes in clinical trials. However, there are still large groups of patients who have limited access to therapy. The major hurdles toward expanding the indication of AAV-mediated liver gene therapy are: i) transient AAV-mediated expression in proliferating hepatocytes, i.e. newborn or regenerating livers, due to dilution of episomal AAV genome in proliferating cells; ii) dose-dependent hepatotoxicity and immune response against AAVs; and iii) pre-existing immunity to AAV capsids, which currently preclude its systemic delivery in about 50% of individuals. AAVolution gathers renowned European experts in the field of AAV vectorology, gene therapy, genome editing and immunology, with the ambitious goal to develop and implement innovative therapeutic tools to effectively address these challenges. To this aim AAVolution proposes: i) to seek novel small Cas nucleases for in vivo AAV-mediated genome editing ii)to develop self-replicating episomal AAVs to avoid transgene dilution in proliferating livers; iii) to generate synthetic AAVs characterized by enhanced potency and reduced toxicity, by screening of novel AAV capsid libraries; iv) and to develop improved technologies to overcome pre-existing immunity to AAVs by transiently reducing the levels of circulating anti-AAV neutralizing antibodies. AAVolution will significantly expand the toolkit for AAV-mediated liver gene therapy, developing novel and improved molecular instruments to address the most relevant hurdles toward safer and more effective therapies, and provide access to treatment to patients that are currently excluded from clinical trials. Moreover, these novel tools will constitute an innovative platform with a potential for broad expansion of disease indications beyond the rare diseases.

Keywords: aav vectors,liver,genome editing,pre existing immunity
Smart City Innovations and Experiments using New Climate and Energy Simulations (SCIENCES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2026-02-28
Duration (months): 41.0
Total project cost (EUR): 296296.32
EU funding (EUR): 296296.32
Participants: 2
Project status: SIGNED

As most of the world’s population lives in urban areas, cities play a key role in the use of energy resources and public well-being. The quality of life in cities, as well as the consumption of energy, is highly compromised by the heat they release and the Green House Gases (GHGs) they emit. For this reason, Horizon Europe and other international organizations are committed to supporting research and innovation for the development of climate-neutral and smart cities. Solutions to improve outdoor thermal comfort and reduce GHGs in cities could be more comprehensively studied if physically-based models simulating interactions between buildings and the outdoor environment were integrated into Smart City Digital Twins (SCDTs). The integration of physically-based models into SCDTs is still encountering difficulties, however, and in my research, I propose to overcome these by: 1) automatically configuring a physically-based model from a 3D city model and an Internet of Things (IoT) platform; 2) using statistical models in concurrence with the physically-based model; and 3) simulating temperature, air flow, humidity, and GHGs in the outdoor air, using the physically-based model. While conducting my research at Carnegie Mellon University and Technical University of Delft, I will diversify my skills and competencies through training activities and through the transfer of knowledge from my supervisors. Together, these will enable me to become a world leader in applying urban microclimate modelling to SCDTs. I will also gain experience in team management and teaching to achieve my career goals in academia. Finally, the collaboration with host organizations and one company in Europe will allow me to extend my professional network in the United States, Europe, and industry.

Keywords: climate neutral and smart cities smart city digital twins physically based modelling 3d city modelling internet of things statistical modelling
Responsible tEerritories and Institutions eNable and Foster Open Research and inClusive Innovation for traNsitions Governance (REINFORCING)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Italy,Austria,Finland,Germany,Spain,Belgium,Serbia
Call: Stepping-up institutional and territorial changes towards open and responsible research and innovation (HORIZON-WIDERA-2022-ERA-01, 2022)
Start date: 2023-01-01
End date: 2027-02-28
Duration (months): 50.0
Total project cost (EUR): 5000082.5
EU funding (EUR): 5000082.5
Participants: 14
Project status: SIGNED

The objective of REINFORCING is to become the ORRI (Open and Responsible R&I) central point of knowledge and expertise, easily accessible, up-to-date and tailored to community needs. It will do so by reviewing and exploiting the richness of 10 years of ORRI-related initiatives, including the RRI Tools database. It will make this know-how available in the REINFORCING One-Stop Source platform, together with new community-led resources, and pathways to support navigation through them. REINFORCING is committed to capitalize on EU-funded actions and the proven expertise of its partners in both the theory and the practice of ORRI implementation. REINFORCING will act as catalyzer of quadruple-helix community members, who will co-develop services, including policy recommendations; of ORRI-related initiatives (regional and EU), to support efficient cooperation and adaptation rather than replication; and of ORRI expertise through the creation of a European map of Ambassadors and Facilitators. A key focus is on financial support of institutional and territorial changes towards Fair Transitions governance through cascading grants. REINFORCING will award 96 grants dedicated to boost institutions scaling up their ORRI experience, and to incubate newcomer territories experimenting with ORRI for the first time. Mentoring and matchmaking services and training modules are part of the REINFORCING wide offer. Reducing disparities is also a key focus of REINFORCING. Three key gaps (Balkan territories, Open Innovation and Mission projects) have already been identified and addressed through specific actions, while the overall project contribution to their reduction will be thoroughly assessed. The engagement of the Global ORRI Network will guarantee wide international cooperation. These efforts will result in a number of medium and long-term impacts, such as over 150 sustainable, individual institutional changes and mainstreaming of excellent, open and responsible R&I across the ERA.

Keywords: open science,open innovation,fair transitions,randi governance,societal engagement,ssh