Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unrevealing dry season Plasmodium falciparum replication biology (NotToKill-NotToDie)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Plasmodium falciparum is responsible for over 200 million yearly malaria cases and the major burden is upon African children. Public health strategies to control and ultimately eradicate malaria are very much needed. In Africa, seasonal transmission of this mosquito-borne parasite is very common. Infections in adults are clinically silent whilst in children it generally leads to clinical disease with nearly half a million deaths each year. The dry season represents a major challenge for the parasite’s survival due to the absence of the transmission vector; yet, P. falciparum seems to be capable of maintaining low parasitemias just enough not to kill but not to die. During the dry season, an important fraction of these children remains clinically silent for months despite the decrease in P. falciparum-specific antibody levels. This low parasitemia reservoir is indispensable to spread transmission in the following rainy season. How do parasites not increase to the point of causing clinical malaria in these children during the dry season? We hypothesize that during the dry season with no mosquitoes available to transmit, continuous rounds of P. falciparum blood stage replication lead to a differential gene expression related to cell cycle progression allowing the maintenance of low levels of parasitemia. The Center for Infectious Diseases, University Hospital Heidelberg has an interdisciplinary and translational orientation and is embedded in partnerships with groups in malaria endemic countries, representing a unique environment to execute the objectives of this project. I offer translational expertise in the malaria from my previous experience in malaria endemic areas of Brazil as well as in state-of-the-art laboratories in the US. This ambitious yet feasible project also offers the opportunity for me to broaden my expertise in malaria by acquiring knowledge in new area, which will allow me to build a solid background from which to become an independent researcher.

Keywords: malaria,plasmodium falciparum,seasonal transmission,parasite replication
RISE International Network for Solutions Technologies and Applications of Real-time Systems (Rising STARS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Australia,Spain,Italy,Switzerland,France,France,France,France,France,Japan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-02-01
End date: 2025-11-30
Duration (months): 70.0
Total project cost (EUR): 634800.0
EU funding (EUR): 634800.0
Participants: 12
Project status: SIGNED

The main goal of Rising STARS is to enable a parallel programming framework for the development and execution of advanced large-scale Cyber Physical Systems (CPS) with High Performance Computing (HPC) and real-time requirements. Overall, there is an urgent necessity to develop run-time parallel frameworks, compatible with HPC, capable of guaranteeing that decisions made at run-time maintains the guarantees about system correctness and timing behavior. These new run-time capabilities however, cannot preclude the ability of run-times to dynamically adapt the execution to new working conditions or changing modes of operation of CPS to maximise the utilisation and performance capabilities of parallel heterogeneous architectures. A key element of the Rising STARS framework will be the incorporation of a unified, efficient and highly configurable data acquisition strategy fully integrated in the parallel programming models with the objective of improving productivity in CPS software development. Exposing the data-acquisition to the programmer (by including it into the parallel programming model) is also key to overlap data-transfers with computation. Another objective of the project is to add this capability in existing programming models for HPC and to investigate new parallel programming extensions to allow developers to define the real-time properties of the system in terms of periodicity and timing constraints. Finally, one of our main objectives is to implement several demonstration platforms to promote the main technological developments of this R&I action and their performance under realistic conditions, including Adaptive Optics for giant telescopes and SSA experiments, data processsing for SKA, and critical real-time embedded systems.

Keywords: parallel programming models,time predictability,energy efficiency,data transfer and acquisition,heterogeneous high performance computing,cyber physical systems,adaptive optics
SMART WAYS FOR IN-SITU TOTALLY INTEGRATED AND CONTINUOUS MULTISOURCE GENERATION OF HYDROGEN (SWITCH)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Italy,Switzerland,Poland,Netherlands,Netherlands
Call: Continuous supply of green or low carbon H2 and CHP via Solid Oxide Cell based Polygeneration (H2020-JTI-FCH-2019-1, 2019)
Start date: 2020-01-01
End date: 2024-03-31
Duration (months): 51.0
Total project cost (EUR): 3746753.75
EU funding (EUR): 2992521.0
Participants: 7
Project status: SIGNED

Solid Oxide Cells are efficient ways to convert variable electricity from renewables in green hydrogen. At the same time, they can be used in a reversible mode to enable the use of other sources (e.g. methane, bio-methane) to match a variable energy production with continuous and guaranteed production of hydrogen for contracted end uses. Switch will focus on the development of this specific solution and realize a mostly green and always secured production of hydrogen, heat and power. Core of the system is a reversible Solid Oxide module based on anode supported electrolyte, supported by an advanced fuel processing unit able to manage steam generation and methane reforming reactions at high efficiency and a purification unit to guarantee highly pure hydrogen in compliance with the main industrial and automotive standards. SWITCH project focuses on the demonstration of a 25kW (SOFC)/75kW (SOEC) system operating in a relevant industrial environment for at least 5000 hrs. Part of the activities will be focused on the issue of cost competitiveness and environmental impact, with the target of the hydrogen price lower than 5 €/kg. The basic solution will be designed to be up scalable to bigger sizes and thus reaching target applications in other different sectors such as industrial, residential and grid services. The modularity, low transient times, an integrated gas treatment unit and different modules combined in between SOFC and SOE mode will set a solution able to modulate between different sources and a flexible production of hydrogen, heat and power, with specific use cases considered.

Keywords: green hydrogen generation,polygeneration of hydrogen,power and heat,reversible soc system
A FIRST STEP TOWARDS AVIATION DECARBONIZATION WITH SMART LITHIUM BATTERIES (ORION PROJECT)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: France
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 3233750.0
EU funding (EUR): 2038597.0
Participants: 1
Project status: SIGNED

With the Orion project, Limatech wishes to accelerate the market launch of its 28V lithium battery range, enabling it to address the largest aeronautic battery market, replace toxic batteries, and generate savings of 1M tons of Co2 within the next 8 years. Limatech develops lithium batteries for cleaner yet safe energy that can revolutionize the aviation sector. Led by a female CEO, Limatech originates from the CEA (French national research laboratory) and benefits from the expertise of an experienced researcher. At a time of commitment to fighting pollution, and the use of toxic products in particular, European directive 2006/66/EC encourages the replacement of dangerous substances in batteries (Cadmium & Lead) by less polluting products. Lithium batteries are currently one of the most relevant responses for replacing these harmful substances. They are also 3 times lighter, last twice as long and require little maintenance. Limatech has succeeded in meeting the challenge of securing lithium batteries for aviation, by developing protective electronics that integrate all the safety functions required with exceptional reliability and precision. Awarded the Airbus Aeronautical Innovation Award in 2019, the technology is now being demonstrated in a real environment and several patents have been filed. The Lithium starter battery is a first strategic step, which will then help decarbonize aviation via the transition to hybrid or electrically-powered aircraft. This innovative technology is highly anticipated by key players in the aviation industry, as it represents a real challenge for European technological sovereignty. Targeting the global market for low-voltage aeronautic batteries, estimated at 850 M€/year, Limatech has already generated significant interest from major European clients. Through the EIC project and our unique selling points, we offer our clients a return on investment in under 1 year and contribute to their carbon reduction objectives.

Keywords: lithium batteries,aeronautics,aviation,industry,transport
Structural basis of Cullin-RING ligase regulation by the COP9 signalosome (EMCOP9CRL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-12
End date: 2017-10-11
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The components of the Cullin-RING Ligase (CRLs) E3 ubiquitin ligase family play key roles in a wide range of cellular processes including stress response, signal transduction, apoptosis and cell cycle progression, and accordingly, defects in their function and/or regulation are prominent in many pathologies including cancer. The modular CRL architecture is centred upon one of seven different cullin scaffold proteins which associate on one side with a RING protein that acts as receptor for an E2 ligase and, on the opposite side, with a substrate receptor (SR) that confers specificity to the complex. The multiplicity of SRs allows the recognition of many different substrates by the same CRL catalytic core. CRL-mediated ubiquitination modulates the substrate´s biological activity and in many cases targets them for proteasomal degradation. The COP9 signalosome (CSN) complex plays a fundamental role in CRL regulation both by forming stable inhibitory complexes with the CRLs where the E2 ligase and substrate binding sites are occluded, and by enzymatically removing Nedd8 (a homologue of ubiquitin) from the cullin scaffold subunit, in a process termed deneddylation, that leads to inactivation of CRLs. CRL regulation by CSN is still an incompletely understood topic mostly because of the lack of high resolution CSN/CRL structures due to the challenge that the crystallization of multi-protein assemblies of such complexity represents. Fortunately, recent technological developments in another structural technique, cryoelectron microscopy, now allow structure determination of relatively small protein complexes (< 500kDa) to near-atomic resolution. Hence, we propose to use this powerful technique to reveal very high-resolution structures of several different CSN/CRL holocomplexes and shed light on the mechanistic aspects of their function.

Keywords: cryoelectron microscopy,single particle,image processing,ubiquitin proteasome system,cop9 signalosome,cullin ring ligase
Imaging SPECtral deconvolution specialist (ISPEC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 95250.0
EU funding (EUR): 95250.0
Participants: 1
Project status: CLOSED

Stand-off trace detection of chemicals in vapour, liquid and condensed phases in real world cluttered and environmentally varied conditions has a range of applications, e.g. oil & gas security & defence and environmental services. Optical detection methods are the most promising solution as they can offer highly sensitive, non-destructive and remote sensing capabilities. Practical systems must be eye safe, compact format, highly sensitive and have an imaging capability. Laser-based, hyperspectral sensing and imaging in the infrared (3-12 µm) offers these benefits but with current technology, the detection limits are too low to address all market requirements. Recently, an active, coherent laser spectrometer that meets these needs was developed by the Rutherford Appleton Laboratory (RAL) and has been developed into a prototype at M Squared Lasers Ltd (MSL). Although the practical elements have been demonstrated there are significant improvements possible in the detection algorithms. Heterodyne IR imaging produces significant volumes of data at high repetition rates that must be interpreted in real-time. Coupling this with inherent changes in intensity and alteration of spectra from heat, moisture and background interferents make this a challenging task. Spectral deconvolution is a niche field in which a unique skill set spanning spectroscopy, programming and photonics is required to tackle the task effectively. MSL have found it hard to source a candidate with the computer programming expertise in search and fitting algorithms and with the practical background in experimental spectroscopy to effectively design and implement a real-time spectroscopic deconvolution method. To meet this innovation opportunity MSL needs to overcome barriers to recruitment by widening its recruitment pool from UK to EU and increasing visibility. This project provides the framework to overcome these barriers and deliver the envisaged project results and impacts.

Keywords: signal processing,spectral deconvolution,imaging
In vivo engineering of monocytes loaded with nano-chemotherapeutic formulations: a novel live-cell mediated drug delivery system for the treatment of cancer (MONONANOCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The success of current antitumoural therapies largely depends on the availability of appropriate drug delivery strategies, which have to allow the penetration of these drugs through the tumoural microenvironment. The knowledge related to the cellular heterogeneity of the tumours has advanced enormously in the last years. Tumour associated macrophages (TAM) can represent up to 50% of the tumour mass. TAM are derived from circulating monocytes, which are recruited from the peripheral blood towards the tumour in response to a broad range of molecular signals (i.e. cytokines). Recently several studies are focused on the development of therapeutic strategies targeting TAM, however, the possibility to use monocytes, with excellent ability to infiltrate the abnormal tumoural tissue, to deliver chemotherapeutic drugs into the tumour has been hardly explored. Here, we aim to use the host monocyte/macrophage cells, with high ability to infiltrate the tumoural tissues, to deliver nano-chemotherapeutic formulations into the bulk of the tumour. We will develop Nano-Formulations consisting in Hyaluronic Acid (HA) nanostructures decorated with beta-glucans, allowing the targeting of specific receptors on the host circulating monocytes (Dectin-1), and at the same time, the loading of chemotherapeutic drugs into these cells. Cytotoxic drugs inducing immunogenic cell death (i.e. bortezomib), and thus the recruitment of new monocytes, will be used to enhance the efficacy of the therapy. Overall, we will use Monocytes loaded with Nano-ChemoTherapeutic Formulations (MNCTFs) as a new strategy to deliver cytotoxic drugs towards the tumoural cells, taking advantage of the infiltration ability of the monocytes/macrophages into tumour microenvironment. The MNCTFs will be tested using appropriate in vitro 2D and 3D tumour models and in vivo murine tumour models. We expect that this new live-cell mediated drug delivery system will provide greater progress in the treatment of cancer.

Keywords: cancer immunotherapy,monocyte,macrophages,nanomedicine,live cell mediated drug delivery
New generation of offshore turbine blades with intelligent architectures of hybrid, nano-enabled multi-materials via advanced manufacturing (Carbo4Power)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Spain,Austria,Estonia,Belgium,Greece,Greece,France,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Materials for off shore energy (IA) (H2020-NMBP-ST-IND-2020-twostage, 2020)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 7898457.5
EU funding (EUR): 6996860.75
Participants: 19
Project status: SIGNED

Carbo4Power will develop a new generation of lightweight, high strength, multifunctional, digitalized multi-materials for offshore wind and tidal turbine rotor blades that will increase their operational performance and durability while reducing the cost of energy production (bellow 10 ct€/ kWh for wind turbines and 15ct€/kWh for tidal), maintenance and their environmental impact. The innovative concept is based on nano-engineered hybrid (multi)materials and their intelligent architectures which breaks down as follows: i) Nanocomposites based on dynamic thermosets with inherent recyclability and repairability and tailored nano-reinforcements to enhance mechanical properties. ii) Multifunctional nano-enabled coatings to improve turbine protection (e.g. against lightning and biofouling (eg. 50% fouling release). iii) Blade segments will be designed and fabricated by advanced net-shape automated multi-material composite technologies that will allow ca. 20% scrap reduction. The approach for WTB is to deliver innovative design of modular rotor blade, while the approach for TTB is aimed towards an optimal design for 'one-shot' manufacture. v) Recycling of blade materials will be increased up to 95% due to the advanced functionalities of 3R resins and adhesives with debonding on demand properties. The strategic goal is to provide the frame which will create new pathways for manufacturing of FRPs for multiple processing life cycles, and explore the emerging valorisation opportunities in offshore energy sector. A multidisciplinary team of 18 partners (8 SMEs) from 8 countries provides technological know-how and industrial leadership, with well-balanced dissemination, communication & exploitation impact.
Previz for On-set Production - Adaptive Realtime Tracking (POPART)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Germany,Norway,Norway,France,France
Call: Support the growth of ICT innovative Creative Industries SMEs (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 1300382.5
EU funding (EUR): 999934.0
Participants: 6
Project status: CLOSED

European film makers are well-known for their creative innovation in selecting themes, their original way of storytelling and their art of cinematography. Like elsewhere in the world, they use computer-generated visual effects to achieve the intended visual experience and quality. To achieve the best interaction between the creative team on set and the post-production team, it is important to achieve the best common understanding between the team filming real scenes and the team working on visual effects. For this, previz has been developed. Previz today contributes to film making from the planning stage to filming with actors on set, where the final composition of mixed reality scenes can be reviewed during and right after the shoot. Large film studios that produce films with the highest budgets take the final step and integrate previz with the final post-production. For this, they develop in-house tools or cooperate with a company that is dedicated to the previz concept. This integration remains unavailable to most film makers and provides a strong competitive advantage. Without the integration, a gap remains between the team filming real scenes and the team working on visual effects in post-production. POPART will introduce an affordable and highly customizable solution that will disrupt the market and overcome this lack of competition. It will democratize the access to a complete previz solution integrated into the pipeline from shooting preparation to post-production, that doesn’t exist on the market. In contrast to the market lock-in solutions, all core elements required for real-time previz will be released in open source and will be based on open standards to provide an highly customizable solution. The product released by POPART will comprise hard- and software components. It will be available at an affordable price, help improve the processes for creative teams in Europe directly, and will stimulate research by providing core libraries in open source.

Keywords: film production,previz,open source