Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PRInted Symbiotic Materials as a dynamic platform for Living Tissues production (PRISM-LT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Sweden,Netherlands,Italy,United Kingdom,Portugal
Call: Engineered Living Materials (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 2805403.82
EU funding (EUR): 2805403.82
Participants: 7
Project status: SIGNED

The PRISM-LT aims at creating a flexible platform for next generation living tissue manufacturing based on Hybrid Living Materials. We plan to design a novel bio-ink where stem cells are integrated in a support matrix enriched with engineered helper cells (either bacteria or yeasts, depending on the application and requirements). Tuning the operational parameters of the bioprinting process, we will cast down the material controlling the mechanical properties of each “voxel”, to get to a 3D patterned structure where stem cells are locally induced to initiate their differentiation towards different lineages. As far as stem cells proliferate, the helpers remain in a quiescent state. However, when the stem cells get stimulated by the local (printed) mechanics and enter a differentiation pathway, they start secreting a pool of lineage-specific metabolites. The helper cells are designed to sense these early markers of differentiation, and to respond by producing in-situ the corresponding growth factors, providing the relevant chemical guidance. Helper cells within the platform amplify the initial lineage commitment in each area and dynamically sustain differentiation on a longer term. During the project we will implement this strategy and develop two independent symbiotic materials, targeting biomedical and food applications, respectively.

Keywords: bioprinting
Towards Cryogenic Applications of Al/Ta Co-doped NiCoCr Medium Entropy Alloy Enabled by Selective Laser Melting (TCAMEASLM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: SIGNED

High/medium entropy alloy (HEA/MEA) with multi-component elements is a novel alloy system developed beyond the traditional metallurgical design. The newly developed foreign-element-doped NiCoCr MEA has demonstrated greater potentials to achieve excellent mechanical performance at low temperatures due to the strengthening effect resulting from the foreign elements. As an important component of Industry 4.0, selective laser melting (SLM), as a branch of additive manufacturing, has become a major industry in EU and worldwide. However, to date, few to no efforts have been devoted into the investigation of NiCoCr MEA fabricated by SLM. Thus, the fundamental knowledge associated with the microstructures and properties of SLMed NiCoCr is still lacking. It is clear that such lack of critical knowledge is a hard barrier for the further development of NiCoCr parts used in cryogenic environment. Seeing this potential, this project proposes a novel alloy design strategy by incorporating nano-sized Al/Ti co-doped NiCoCr powder into the SLM process. This proposal will focus on: (1) Alloy composition design used for SLM; (2) Investigation of layer-by-layer twinning mechanism; (3) Temperature-induced mechanical response upon tension deformation; (4) Tailoring of cryogenic strength-ductility synergy. The combination of Al/Ti co-doping and SLM process create a possibility for SLMed NiCoCr to enable different microstructures and superior properties over its conventionally manufactured counterparts. It is expected that the new knowledge generated from this project will allow the 3D printing of complex MEA parts with excellent strength-ductility balance in cryogenic environment. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. Results have the potential capacity to increase the competitiveness and provide room for further studies at the fundamental and applied levels in additive manufacturing.

Keywords: unlike conventional material removal processing method,selective laser melting enables realizing quick production of three dimensional parts with any complex configurations directly from powders
Accurate diagnosis and prognosis of Alzheimer’s disease in primary care (ADetect)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: CLOSED

The overall objective of ADetect is to improve early diagnostics and prognostics of Alzheimer's disease in primary care by utilising novel plasma biomarkers and digital cognitive tests. Misdiagnosis of AD can reach >50% in primary care, which has important consequences both at the personal and societal level. Misdiagnosis, however, can be reduced by measuring AD-related pathology. The novel plasma biomarkers may be a cost-effective alternative given their low invasiveness and costs. However, they have not been validated in primary care yet, where much more diverse groups of people are managed. Further, the addition of brief cognitive digital tests that do not require involvement of a specialist may further improve the diagnostic accuracy. Based on the most cost-effective biomarkers, collected in unique prospective study performed in primary care, we will develop algorithms for diagnosis and prognosis of AD in a diverse population, and share them in the form of open and freely available apps. The algorithms will be validated against current standard of truth biomarkers and enhanced to give personalized risk assessments based on patient’s characteristics. Finally, we will investigate whether prospective use of these algorithms will improve treatment, management and care of patients. The development of easy-to-use tools, built on novel cognitive tests and plasma biomarkers, has huge potential to increase the diagnostic accuracy in primary care. A more accurate and timely diagnosis will lead to earlier initiation of currently available AD treatments. Further, when disease-modifying treatments become globally available, there will be an immense pressure on the healthcare system to identify eligible patients. Given the high prevalence of AD, its identification will primarily take place in primary care. With the easy-available proposed biomarkers, we have a great opportunity to develop the necessary tools for primary care to undertake this important task

Keywords: alzheimer s disease diagnosis prognosis primary care plasma biomarkers digital cognitive tests algorithms personalised medicine patients management screening tests
Sustainable Technologies for Reducing Europe’s bAttery raw MaterialS dependance (STREAMS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Austria,Norway,Türkiye,Poland,Greece,Ireland,Ukraine,Australia,United States,United Kingdom,Finland,Spain,Belgium
Call: Technologies for sustainable, cost-efficient and low carbon footprint downstream processing & production of battery-grade materials (Batt4EU Partnership) (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6108632.62
EU funding (EUR): 6094993.25
Participants: 19
Project status: SIGNED

In STREAMS, a comprehensive portfolio of at least 12 scalable and flexible technologies and pilot scale solutions for the sustainable production of battery-grade precursors and their respective anode and cathode active materials will be developed, evaluated and successfully demonstrated. These technological processes will be applied to materials from primary and secondary sources including recycled battery mass and photovoltaic waste. This will strengthen Europe’s domestic battery materials supply chain and reduce Europe’s dependency on imported critical and strategic raw materials supplies. The production technologies will also increase Europe’s resilience, competitiveness and strategic autonomy in the global battery manufacturing industry. STREAMS’ technological solutions will meet EU requirements for environmentally responsible design, and scale up, and anticipate regulatory compliance by conducting techno-economic, environmental, social impact and integrated risks assessments combined with life cycle sustainability and circularity assessments. The cathode and anode active materials synthesized in STREAMS will be used to manufacture 10 Ah battery cells at pilot scale using sustainable electrode processing. Prototype cells will be tested according to established standards and subjected to advanced post-mortem characterization. STREAM will also identify optimal conditions for future exploitation of the project results.

Keywords: battery grade intermediates,recovery,recycling,reconditioning,sustainable processing,purification processes,raw materials,primary and secondary sources,black mass
Recycling plastic waste into high-value materials- Closing the Loop (Plastics2Olefins)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Spain,Norway,Thailand,France,Germany,Finland,Denmark
Call: Plastic waste as a circular carbon feedstock for industry (Processes4Planet Partnership) (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 28208658.5
EU funding (EUR): 18084895.0
Participants: 14
Project status: SIGNED

Globally 359 million metric tons of plastic were produced in 2018 and Europe produced 17% of this amount. In the same year, 29.1mio tons of plastic waste was generated in the EU and only a third was recycled. While sorted and pure plastic waste can be recycled relatively well, a major problem is recycling of unsorted waste, which still holds a large share of valuable carbon feedstock but is currently either landfilled or energetically valorised, i.e., incinerated, both producing greenhouse gases (GHG) emissions instead of recovering the precious carbon feedstock contained. Hence, there is an urgent need to develop new technologies that can not only valorise unsorted plastic but also other waste in large amounts to yield material streams that can replace fossil material streams. One promising technology to recycle unsorted heterogeneous plastic waste is pyrolysis. While the low to medium temperature pyrolysis (400C) produces mainly liquid oil that needs to be fed into the furnace of the steam cracker unit (at higher temperature than 900C) to produce olefins, with our proposal, at high-temperature pyrolysis (<850C) syngas stream (light olefins rich) is fostered and could be integrated downstream the furnace of the steam cracker. However, the use of high-temperature pyrolysis for plastic waste recycling has not yet become an industrial practice since gas treatment and integration present a great challenge. Plastics2Olefins project will address this challenge - it will design, build, and run a demonstration plant for recycling of unsorted plastic waste at Repsol's plant Puertollano (Spain), which will be digitalised and run on 100% renewable (electric) energy. The project estimates to reduce the lifecycle GHG emissions by 70-80% compared to incineration and existing plastics recycling processes providing an important contribution to the EU reaching climate neutral by 2050 and set a pathway for commercialisation of renewable plastic feedstock replacing fossil fuels.

Keywords: mixed unsorted plastic waste,recycling,pyrolysis,olefins,reducing ghg emissions
The Rise and Decline of a Solidarity Movement: Palestinians and the Radical Left in West Germany, 1950s-1980s (PalSol)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

This project studies the shifting trajectory of pro-Palestinian activism in West Germany, between the 1950s and 1980s. At its center is the question of how we can explain that contemporaries in West Germany began to support Palestinian politics and later withdrew their solidarity. In order to answer this question, the project will study for the first time Palestinian and German archives together. With this approach, it proposes a new focus on the role of migration and ties to the Middle East for solidarity politics in the West German left. The reasons for the rise of Palestine solidarity movements during the 1960s and their decline in the 1980s are a much-discussed topic in the history of the Western European left. With the legacy of the Holocaust and an earlier support for Israel in the West German left, this trajectory is particularly puzzling in the case of the Federal Republic. Historians have sought to explain this puzzle by focusing on continuities in the history of Antisemitism and a changed perception of Israel after the Six-Day War of 1967. PalSol breaks new ground by studying Palestinian sources on the solidarity movement in West Germany. These sources provide a fresh vista on everyday interactions and the role of the Palestinian diaspora in bridging leftist politics between places like Beirut and Bonn. Pursuing a transregional approach, the project promises to shed light on how political struggles in Europe and the Middle East became integrated and disintegrated between the 1950s and 1980s

Keywords: german history,palestinian history,european history,history of the middle east,history of the left,transregional history,migration history,oral history
Identity, Nation and Treason in Turkish Concept of Authority. (IhaNeT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland,Türkiye
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 412700.52
EU funding (EUR): 412700.52
Participants: 3
Project status: SIGNED

Discourses surrounding “enemies within”, traitors, and “fifth columns” are prevalent in public discourse, creating negative archetypes that can be stigmatized based on political stances, cultural behaviors, or belonging to a particular religious or ethnic group in every society. Concurrently, these narratives reinforce boundaries of collective identities, delineating us/them, majority/minority, and hero/traitor dichotomies. While hate speech has been repeatedly addressed by the EU commission, the mechanism that guide the construction of negative dehumanized stereotypes are still not adequately analyzed. IhaNeT is an interdisciplinary project that aims to improve the understanding of the concept of treason (ihanet in Turkish), in its collective dimension, in Türkiye. This country represents a compelling case study due to the pervasiveness of the concept of treason in public discourse, media, and memory throughout history. Covering the period from the collapse of the Ottoman Empire (1918) to the failed military coup of 2016, IhaNeT aims to elucidate the evolution of treason in its legal, discursive, and subjective dimensions, thereby contributing to the understanding of the concept of political authority. To achieve this overall objective, I will adopt a strongly interdisciplinary approach, drawing on history, cultural studies, media studies and discourse studies. Accordingly, I will use methods such as archival research, content analysis and discourse analysis to examine a corpus of legal, media and autobiographical sources. I will be supervised by three top-rank scholars, Fabio Grassi (Sapienza University of Rome, Beneficiary), Serena Tolino (Universitait Bern, Outgoing) and Ayhan Aktar (Hrant Dink Foundation, Secondment) who will offer me optimal research environment and training opportunities. The activities conducted within IhaNeT will allow me to establish myself as an internationally recognized and independent scholar with developed project management skills.

Keywords: turkey,treason,public discourse
Investigating glucocorticoids as regulators of lipid-mediated metastatic spreading of triple negative breast cancer (GlucoDrop)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 217076.16
EU funding (EUR): 217076.16
Participants: 1
Project status: SIGNED

Triple negative breast cancer (TNBC) is the most aggressive and lethal breast cancer subtype, but it lacks expression of the estrogen receptor, the canonical driver of breast cancer development and progression. This indicates that there may be other molecular drivers in this context. The glucocorticoid receptor (GR) is a candidate oncogenic factor in TNBC, that has been shown to support TNBC cell proliferation and metastatic spread. Therefore, GR antagonism may be a viable strategy to attenuate TNBC aggressiveness, however, the precise molecular mechanism of GR action in TNBC cells remains to be determined. Recent experiments performed in the host laboratory demonstrated that GR activation induced lipid droplet (LD) accumulation, and shifted the balance of the metabolic mTOR signaling complexes, promoting mTORC2 activity, in breast cancer cells. Given that mTORC2 is a regulator of lipid metabolism, and has been implicated in the aggressiveness of TNBC, these observations are compelling and may be linked. Therefore, this project aims to investigate the role of these changes in regulating TNBC metastatic spread, by determining the precise molecular mechanism to explain these effects. To achieve these aims, I will firstly determine the interactome of the GR-induced mTORC2 and investigate the consequences of these specific interactions in TNBC cells, including on LD accumulation. Subsequently, I will use patient-derived organoids to determine the contribution of the GR-induced LDs to TNBC metastatic capacity and oncogenic phenotypes. The successful completion of this project will answer key questions relating to the role of GR as an oncogenic factor in TNBC, and define a novel interaction between the GR and mTORC2 signaling axes, which has never been described. In the long term, these findings could facilitate the design and implementation of novel therapeutic options for TNBC, to improve the outcomes for patients diagnosed with this aggressive breast cancer subtype.

Keywords: glucocorticoid receptor,mtorc2,lipid droplets,triple negative breast cancer,metastasis
Metal-Organic-Framework Kinetic Array for Diabetes Detection (MOFKADD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-11-01
End date: 2026-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Diabetes mellitus is a global health concern affecting 537 million people and resulting in over 6.7 million deaths yearly. Diagnosis currently relies on blood analysis, which is expensive, time-consuming, and invasive. Breath analysis based on the detection of volatile organic compounds (VOCs) is a promising non-invasive alternative. However, selectively measuring specific VOCs in breath is challenging due to their low concentrations and the presence of interfering compounds. Since current miniature sensors cannot efficiently distinguish between VOCs, there is a need for a novel technology capable of distinguishing a VOC of interest from a complex background. This project aims to address this challenge by combining a highly promising class of porous crystalline materials, metal-organic frameworks (MOFs), with sensor technology. A novel sensing concept based on the kinetic selectivity in the pores of the MOFs will be leveraged to mimic nature’s approach to olfaction and enable selective sensing. A demonstrator will be established to enable diabetes mellitus diagnosis and prove the breakthrough potential of this disruptive sensing platform.