Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
proactive monitoring of cancer as an alternative to surgery (PRISAR2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Germany,Italy,Italy,Germany,Germany,Germany,Slovakia,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 2484000.0
EU funding (EUR): 2484000.0
Participants: 25
Project status: SIGNED

From 2016 -2019, the “first” PRISAR consortium implemented the first Dutch RISE project of H2020 to investigate the use of imaging technologies and hybrid fluorescence/radionuclide probes for the surgical intervention of cancer. This PRISAR project provided a career-enabling human resource plethora of inter-disciplinary and inter-sectoral secondments, which resulted in the development, of not only a hybrid probe for image-guided surgery, but also a variety of tools and instruments. We now propose a new project, PRISAR2, to implement the next logical phase of this work, which is to clinically translate new and innovative monitoring technologies from industry. This will provide better patient selection and increase the surveillance window to allow for better treatment options over time and avoid surgery. This will involve developing new ‘watch and wait’ strategies to study the behaviour of the cancer so that any risks can be minimized. This would lead to a better clinical outcome and quality of life (QOL) for the patient and maximize the benefits of an active monitoring policy for both the patient and the healthcare system. When a patient is discovered to have cancer, one of the primary goals is to have the tumour removed by surgery. Here, however, we aim to (a) develop new monitoring technologies from industry so that the surveillance window can be increased to allow for better treatment options over time and to avoid surgery, (b) develop new ‘watch and wait’ strategies in order to study the behaviour of the cancer so that any risks to the patient can be minimised leading to a better clinical outcome and (c) train a new generation of preclinical and clinical scientists to be able to implement this new concept as standard of care and to maximise the benefits of an active monitoring policy.

Keywords: tool development,physical sciences,rectal cancer,active monitoring,surveillance,imaging,watchandwait,diagnostics
Biomolecule Sensing with Graphene-Integrated Nanogaps (BioGraphING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Monitoring the DNA and protein composition of cells is key to understanding most biological processes, including the molecular origins of specific diseases. To this end, the emerging field of molecular electronics offers unique opportunities for label-free single-biomolecule sensing. In particular, tunnelling current modulations caused by trapping an individual molecule in a nanoscopic gap between two electrodes can be used to discriminate species based on their electronic structure. The junction conductance is highly sensitive not only to the structure of the molecule, but also to the gap size, the voltage applied, the bonding arrangement inside the gap and the immediate molecular environment. Mechanically controlled break junctions (MCBJs) that allow the formation of closely-spaced electrodes with picometer resolution, can exert a degree of control over each of these parameters and therefore represent an ideal platform for in-situ studies at single-molecule level. In BioGraphING, I will develop the first graphene MCBJ, a unique device that will be both a model system for studying charge transport in molecular junctions at room temperature, and a sensing platform for biomolacular fingerprinting. Graphene’s atomic thinness, chemical inertness and strong in-plane bonds will lead to a device architecture with superior mechanical stability and measurement resolution. Given that a robust and reliable contact to single molecules is crucial for high junction conductance, various anchoring modes of the molecules to the graphene electrodes will be investigated (e.g. covalent bonding, π-π stacking). I will monitor the molecular conductance as a function of electrode distance and bias voltage in air, vacuum and in liquid. Combined with quantum transport simulations and statistical data analysis my final goal is to establish molecular fingerprints for amino acids and peptides with specific biological functions, an important challenge in single-molecule biophysics.
Fate and Toxic Effects of Silver Nanoparticles and Its Transformation Products in Soil Applied with Biosolids (TESNinSAB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Türkiye
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-01
End date: 2019-08-28
Duration (months): 24.0
Total project cost (EUR): 145845.6
EU funding (EUR): 145845.6
Participants: 1
Project status: CLOSED

Sewage sludge management is one of the most challenging waste issues in Environmental Engineering field due to their highly polluted nature and high volume. On the other hand, sewage sludge, which is also called as biosolids, can be a nutrient resource for the agri-foods which leads to their usage in agriculture as fertilizers. Usage of biosolids as fertilizer is the most desirable management strategy since it provides resource recovery and prevents the usage of synthetic chemicals which can be harmful for human and environment health. Therefore, after the treatment of biosolids to meet the required quality criteria, their ultimate disposal as fertilizer has to be sustained. Up to date, organic, metallic or hazardous pollutants were addressed to be removed from biosolids before land spreading and standards were defined in regulations. However, there are new concerning pollutants for biosolids application to agricultural lands. One of the most recent and biggest concerns is the presence of silver nanoparticles (AgNPs), which are widely used as biocides in the consumer products and are shown to occur in wastewater treatment plants, mostly, in biosolids. They are, as a source of ionic and nano Ag, among the emerging pollutants which are known to have potential to pose threat to human and environment health and have not been included in monitoring lists, yet. Therefore, the aim of this research is to advance the state of the art in land spread of biosolids through the investigation of the toxic effects and bioacculumation of AgNPs and its transformation products in soil organisms. For excellence in research, the knowledge about the toxic effects is integrated with environmental risk assessment which will enable necessary actions such as proposing guidelines for biosolids applications.

Keywords: agglomeration,agriculture,bioaccumulation,enchyrtaeus crypticus,engineered nanoparticles,environmental risk assessment,pore water,public health,resource recovery,transformation product
References to Environs are Coordinated to be Heard and Seen (REaCHeS): an investigation of multimodal spatial referencing in Eastern Chatino (REaCHeS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

To locate objects in the world, speakers typically use two linked indicating behaviours: spatial deictic expressions and pointing gestures. A growing body of research focuses on both of these indicating types, asking how semantic information is encoded in each modality, and investigating the factors that condition speakers’ use of indicating strategies in isolation and in combination. The proposed research programme will explore these questions by examining multimodal indicating behaviours in speakers of Eastern Chatino (Zapotecan, Otomanguan). The language presents an ideal system for examination because of its typologically unusual demonstrative system; its manual pointing system with distance-encoding formational distinctions; and its additional lip pointing system. The planned research programme comprises two studies that probe the semantic encodings of demonstratives and lip- and manual pointing, as well as the factors that motivate speakers to combine them. In Study 1, semistructured interviews will be performed in which speakers describe features of the landscape while walking familiar routes. Video and audio recordings of the multimodal talk in these interviews will be analysed using traditional tools of descriptive linguistics, along with a GIS tool adapted expressly for the research programme to encode the relative geospatial positions of speakers, addressees, and referents. Analysis will generate hypotheses about semantic distinctions encoded in various demonstrative and pointing forms. These, in turn, will be tested In Study 2, a more controlled quasi-experiment (a referential communication task) designed to isolate factors like distance and in/visibility of referent that are often coupled in discourse environments. The research programme is ambitious in its use of new tools to examine multimodal behaviour in a lesser-studied language. Expertise of Chatino speakers and researchers from multiple linguistic subdisciplines will inform its design.

Keywords: spatial reference,spatial cognition,multimodality,demonstratives,pointing,lip pointing,semantic encoding,co organization of cues,language description,research tools
Material Minds: Exploring the Interactions between Predictive Brains, Cultural Artifacts, and Embodied Visual Search (XSCAPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Spain,United Kingdom
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-11-01
End date: 2027-10-31
Duration (months): 72.0
Total project cost (EUR): 10279971.0
EU funding (EUR): 10279971.0
Participants: 3
Project status: SIGNED

Do the worlds we build alter our own minds and the ways we process information? Do the material structures of our settlements, buildings, roads, and artefacts actively change patterns of thought and attention, so that understanding change in these ‘material codes’ becomes part and parcel of understanding the emergence of the modern mind? To answer these questions XSCAPE brings together a unique team from archaeology, vision science, and cognitive philosophy. Using a carefully curated set of materials, spanning a range of cultures and a wide sweep of historic and contemporary settings, we aim to test, for the first time, the hypothesis of materiality-driven cognitive change. To this end we will use a new synergistic methodology that combines multiple real-world case studies with state-of-the-art visual neuroscience, and simple agent-based simulations. The practical core of the project comprises a series of 41 different world-wide case studies. Together, these will constitute the largest ecological experiment on embodied visual perception ever attempted. A successful Pilot Study (described in detail in the main text) using eye-tracking analysis as applied to the visual exploration of archaeological artefacts already demonstrates the scientific and practical feasibility of our approach. For the simulations, we will use the emerging paradigm known as ‘active inference’ which describes a principled means of linking perception, attention, and actions (including eye-movements) with cognitive change and learning. This will deliver insights into the fundamental principles that may be guiding materiality-driven cognitive change. Using this unique combination of archaeological materials, visual neuroscience, and simulation- based studies, XSCAPE will deliver the first fully-integrated framework for understanding the potent yet ill-understood cycles by which we humans make and transform the landscapes, practices, and artefacts that make and transform our minds.

Keywords: archaeology,cognitive sciences,predictive brain,situated cognition,mind,visual cognition,material culture,agency,visual statistics,cognitive primitives,perception,inference,causality,attention,visual search,gestural exploration,human behaviour,social complexity,architecture,landscape perception
BEhavioral and Adherence Model for improving quality, health outcomes and cost-Effectiveness of healthcaRe (BEAMER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Spain,Ireland,Germany,Germany,Germany,Spain,Italy,Germany,Spain,Norway,Switzerland,Belgium,Switzerland,Norway,Greece,Belgium,France,Netherlands,Netherlands,Netherlands,Netherlands,Portugal,Portugal,Denmark,United Kingdom
Call: Behavioural Model of Factors Affecting Patient Adherence (H2020-JTI-IMI2-2020-23-two-stage, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 11794911.75
EU funding (EUR): 5948903.25
Participants: 31
Project status: SIGNED

The main objective of the Project is to create BEAMER, a disease-agnostic behavioral and adherence model for improving quality, health outcomes and cost-effectiveness of healthcare, through improving the quality of life of individuals, enhance healthcare accessibility and sustainability. The model will allow for tailoring to individual?s needs, using Real World Data captured from patients? behaviors and health system information, transforming the way healthcare stakeholders engage with patients to optimize understanding of their condition and adherence levels throughout their patient journey. BEAMER is driven by a set of Ontology, Epistemology and Methodology principles, supported by Artificial Intelligence, Natural Language Processing, and Machine Learning. BEAMER will optimize the disease-agnostic adherence model by real-life testing proof-of-concept in 18 different pilots in Norway, Spain, the Netherlands, Germany, Portugal, and Italy, including over 18,000 patients (3000 patients in each thematic area). BEAMER will be embodied in an open source European searchable database, continuously updated, validated and optimized by empirical evidence and new insights, available to all stakeholders and adaptable for future developments in healthcare. Finally, extensive efforts will be directed to develop and implement dissemination and communication activities that increase exploitation and sustainability of BEAMER.

Keywords: comprehensive behavioural theoretical framework for patients adherence to treatment
NEURODIVERSITY BETWEEN LAW AND SCIENCE (NEDBELS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 159034.56
EU funding (EUR): 159034.56
Participants: 2
Project status: CLOSED

The aim of the research proposal “Neurodiversity between Law and Science” (NEDBELS) is to inquire into the legal impacts and socio-political implications of the concept of neurodiversity. This term pertains to individuals diagnosed with neurodevelopmental disorders such as Asperger’s Syndrome and Autism and hypothesizes the emergence of a new category of difference in the human population. NEDBELS explores how this concept challenges the constitutional principle of equality, as well as how it fosters the need to accommodate new principles in criminal and civil law. This proposal has risen from a need for heightened communication between law and science. Scientific theories, concepts and methods widely permeate law and adjudication, and legal and ethical frameworks intimately drive applied sciences, as in education and health care systems. Therefore, one might reasonably expect that these two worlds would cooperate on a regular basis. However, lawyers, scientists and health care professionals operate largely insulated from one another in research, formal training and daily practice. This divergence prevents vulnerable minorities, such as people with neurodevelopmental disorders, from reaping the full socio-political potential of scientific advancements. NEDBELS’s goal is to increase communication between law and neurosciences through interdisciplinary research methodologies and scientific training-through-research as well as by enhancing the synergy among legal experts, policy makers and scientists in the field of neurodiversity

Keywords: comparative constitutional law,comparative constitutional adjudication,discrimination,principle of equality,human diversity
The first automatic conductive charger for electric vehicles (DazePlug)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 3979375.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Daze Technology, an Italian high-tech start-up, has developed DazePlug, the first totally autonomous conductive charging system for Electric Vehicles (EV) to automate EV recharge. EV are the future of mobility and 2022 is expected to represent an important turning point for electric mobility, as the price of EV is forecasted to be on par with the price of their combustion engine counterparts. Studies by Deloitte, PwC and McKinsey have pointed out that there are two basic issues that are keeping a share of customers away from the adoption of EV: 1) the “range anxiety”, which basically reflects in the question “Will I manage to reach my destination and come back?”;2) the “User Experience”, which deals with the complexity of the charging operations. We all know how to refuel our combustion engine cars, but charging an electric vehicle is a completely different story. Despite the wider availability of public charging stations, 90% of users are adopting and will still adopt home charging. However, who had the chance to perform manual EV charging knows that the cable is bulky and heavy and to avoid accidents the driver must be sure that the cable is dry and not coiled before starting the charge. Besides, once finished, the cable must be unplugged and stored safely. DazePlug solves this problem through a robotic connector, placed on the ground and connected to an electrical power supply network, and an on-board device installed under the car and directly connected to the vehicle’s battery. The off-board robot automatically reaches the plug and connects itself to the vehicle once the parking is completed, allowing the complete automation of the charging process through a simple plug&play socket kit, dramatically enhancing the user experience. This EIC Accelerator project will allow Daze to take the technology to the industrial stage, cooperating with a prominent OEM (Maserati), an energy utility (Engie) and a TIER-1 supplier (Zollner).

Keywords: automatic charging,electric vehicles
Wireless with Increased Network Density, Antennas, Spectrum and Heterogeneity (WINDASH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-12
End date: 2019-11-20
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

The H2020 "Digital Agenda for Europe” Flagship Initiative has the goal of providing all EU citizens with Internet speeds above 30Mbps and above 50% households above 100Mbps. Delivering such speeds and reaching so many households will require the creation of a new generation of wireless access networks. This action will study Wireless with Increased Network Density, Antennas, Spectrum and Heterogeneity (W.I.N.D.A.S.H.). Wireless communications increasing these resources received little attention in the past due to technical difficulty. However, traditional wireless systems with not-so-large bandwidth, antenna arrays and density are operating close to the capacity limit and research must move on to higher frequency bands, antenna architectures with massive numbers of elements, and increased device density, in order to deliver new significant increments in capacity. Such ambitious redesign of classic wireless systems will require simultaneous innovation in multiple fields, including the signals in the physical layer and the wireless network architectures and behaviors. This project follows a cross-layer interdisciplinary approach with collaboration between two excellent research groups that contribute complementary expertise: The Wireless System Group at Stanford University (communications), and the SIGNET group at University of Padova (networks). The main research objectives of this action are 1. To study the fundamental properties of the relation between a wireless network capacity, its architecture and increased bandwidth, antenna dimensions and density. 2. To bridge the gap between the physical and network layers on this research field. 3. To design wireless network architectures that maximize the potential benefit of increased resources. 4. To develop optimal resource allocation schemes that maximize network performance in these architectures. 4. To create simulation and demonstration tools that verify the results and ease transfer of solutions to industry.

Keywords: wideband,mmwave,massive mimo,multi hop networks,scheduling