Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New insights on Earth’s formation and differentiation processes from in situ analyses of halogens (F, Cl, Br and I) in meteorites and mantle samples (HAMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2023-07-01
Duration (months): 36.0
Total project cost (EUR): 304724.16
EU funding (EUR): 304724.16
Participants: 1
Project status: SIGNED

Halogens (F, Cl, Br and I) are involved in key processes of the Earth and Planetary sciences. However, some crucial challenges of halogens’ geochemistry are unsolved. They include (i) halogen abundances in the Earth’s primitive mantle (PM) with implications on their origin and evolution during Earth formation and early differentiation; (ii) their behaviour during subduction to the Earth’s mantle; and (iii), their magmatic-volcanogenic fluxes from the mantle to the crust at subduction zones (SZ). Halogen geochemistry is currently hampered by analytical and sampling limitations. The suitability of reference halogen values in glass standards for in situ analysis is disputed. It has been also shown that indirect inferences from the whole-rock compositions of magmas are limited for fully assessing the chemical geodynamics of halogens. Technique and methodology leaps are needed to allow the in situ analysis (i.e. in minerals) of mantle and crust rocks, and to address fundamental questions in halogen geochemistry. I propose to analyse halogens in the minerals of meteorites, and unique PM-like intraplate, SZ and cratonic mantle rocks. This research will enable to define new benchmark values for meteorites and PM and determine how halogens are recycled to SZ magmas and to the deeper mantle. I will produce new standards, which in combination with analytical developments, will provide unique data about the volumetrically important mantle reservoir. In the final phase of the project, I will study halogens in the mineral-hosted melt inclusions of magma-percolated mantle and crust rocks to derive partitioning coefficients and model their SZ magmatic-volcanogenic fluxes. The research will settle in an interdisciplinary, collaborative network to stimulate breakthrough outcomes in geochemistry, cosmochemistry, volcanology and economic geology. It will significant upgrade my technical and scientific capabilities and will allow me to reach a leading position in volatile geochemistry.

Keywords: halogens,fluorine,chlorine,bromine,earth s mantle,earth s crust,earth formation,earth s mantle differentiation,meteorite,primitive mantle,intraplate mantle,subduction zone mantle,arc magma
Non-linear, control-informed optimisation of innovative wave absorbing structures using highly-efficient numerical methods (InWAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-10
End date: 2023-12-12
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Throughout the InWAS project, the experienced researcher (ER) will apply computationally efficient numerical techniques to the non-linear, control-informed optimisation of innovative wave absorbing structures (InWAS). The project will accelerate the integration of wave energy into the European electricity mix, by developing more efficient designs. It will also help in disseminating innovative numerical methods amongst fluid dynamicists for other pertinent applications. The fellowship will be carried out at the ESPCI Paris within the PMMH lab (Physics and Mechanics of Heterogeneous Media), with the Biomimetics and Fluid-Structure Interaction group, under the supervision of Dr Ramiro Godoy-Diana and co-supervision of Dr Benjamin Thiria. The project will benefit from PMMH’s renowned expertise in theoretical and experimental hydrodynamic modelling, and the ER will make the most of this ideal working environment to extend his own skills and his research network. Two secondment periods, through stays at the Centre for Ocean Energy Research (COER), Maynooth University, Ireland, will be carried out under the supervision of Prof. John Ringwood. The secondments will ensure that the control-related aspects of the project are handled in a state-of-the-art fashion, based on COER’s leading academic status in system dynamics and control applied to wave energy. The project will yield novel licensable ideas with significant commercial prospects. By the end of the fellowship, the ER will have progressed on his way to become a recognised researcher, able to initiate and supervise his own projects at the intersection of fluid mechanics and non-linear system analysis and control.

Keywords: wave energy,ocean energy,design optimisation
INVESTIGATING THE IMPACT OF NUTRITIONAL METABOLISM ON DNA DAMAGE REPAIR IN CANCER (METAREPAIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

Preclinical and epidemiological studies indicate that some dietary patterns, such as high-fat diet (HFD), are associated with increased risk for many cancers, including prostate cancer (PCa). However, our mechanistic understanding of the link between diet and cancer remains limited. To help deconvolute the connection between nutrition and tumorigenesis, METAREPAIR will investigate the role of genomic instability in mediating the effect of nutritional metabolism on PCa aggressiveness. I hypothesize that the oncogenicity of ‘HFD-like’ diets is in part due to a diet-induced erosion of DNA repair capacity caused by altered epigenetic and epitranscriptomic landscapes. Based on enticing preliminary data indicating that diet-dependent alterations of one carbon metabolites can impact DNA damage repair efficacy and DNA repair-pathway choice, I present a model whereby changes in nutritional metabolism affect the activity of writers and erasers of histone and RNA methylation marks and consequently impair their role in orchestrating DNA damage repair. I will test this model by manipulating in vitro the levels of key metabolites and then use an innovative experimental toolkit to assess the dynamics of DNA repair in PCa cells. The effect of metabolic manipulation onto DNA repair will be studied through the mechanistic lens of RNA and histone methylation. This diet-DNA damage link will be tested in vivo as a tool for precision nutrition intervention to sensitize PCa tumours to DNA-damaging therapies. The findings of METAREPAIR could unveil a yet-unexplored link between metabolic perturbations and genomic stability, with far reaching implications at fundamental as well as translational level. By allowing me to deliver innovative science in both the applied and basic aspects of DNA repair and RNA role in it, METAREPAIR represents a career-changing opportunity that will place me in a strong position to pursue my next career step of becoming an independent researcher.

Keywords: cancer metabolism,high fat diet,dna damage response,dna repair,epigenetics,epitranscriptomics
Fully Integrating Atomistic Modeling with Machine Learning (FIAMMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1998015.0
EU funding (EUR): 1998015.0
Participants: 1
Project status: SIGNED

Computer simulations of molecules and materials are undergoing a profound transformation. Machine learning (ML) has become essential to extend the reach and increase the predictive power of atomic-scale modeling. The potential of ML in association with quantum mechanical (QM) and statistical mechanical (SM) methods has been shown, but the link has been rather superficial, due to the complex, interdisciplinary effort needed to combine the three approaches. Without full convergence, ML-powered simulations cannot address modern modeling challenges, which involve complex materials in realistic conditions, and require increasingly predictive accuracy. The objective of this project is to create a “plug and play” framework by which ML can be seamlessly combined with physics-based modeling, substituting individual steps of a QM calculation, or making direct predictions across complex SM workflows. Full integration of the three approaches will greatly extend the reach of atomistic simulations, and allow an insightful critical comparison of the role of inductive and deductive paradigms in theory and modeling. The development of an open-source software that unifies QM, SM and ML shall facilitate early adoption and broaden impact. We will demonstrate the benefits of our integrated framework through two challenging and compelling platform problems: (i) investigating stabilities and properties of flexible drug-like molecules and assemblies, and (ii) discovering fundamental structure-activity relationships of porous aluminosilicates for clean chemical technologies. Critical knowledge gaps that will be filled include: (1) the description of long-range physics within the same conceptual framework that has been used for short-range interactions; (2) the symmetry-adapted representation of input and outputs of each step of a QM calculation; and (3) the rigorous characterization of SM ensembles to enable end-to-end predictions of equilibrium properties with uncertainty quantification.

Keywords: atomistic modeling,machine learning,molecular dynamics,molecular materials,zeolites,catalysis
On the financialisation of green: Chinese operations along the Belt and Road Initiative (BRI). (CHINGREEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Singapore
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2024-10-31
Duration (months): 36.0
Total project cost (EUR): 267282.24
EU funding (EUR): 267282.24
Participants: 2
Project status: SIGNED

CHINGREEN is an in-depth qualitative study of Chinese "green-finance" operations along the Belt & Road Initiative (BRI). The project explores the increasing expansion of Chinese green finance by asking to what extent this is (re)shaping the definitions of global green financial practices and thus the relationship between nature and finance. The issuance of Green Bonds and the adoption of green financial securitisation for the funding of green infrastructures are among the main tools China has adopted in its global extraversion. In this unprecedented expansion, it is now clear that the extent of Chinese-led green credit along the BRI will have a make-or-break role in meeting the Paris agreement’ emissions targets. However, as a common “green” language is yet to be established, the way financial products are defined and capitalised as “green” remains contingent and unclear. Challenges remain concerning processes of standardisation and measurement of green financial practices at a global level. This research aims to address this knowledge gap by investigating the special characteristics of Chinese “green” financial capital and how it deploys out of the Chinese domestic borders. The research will consist of an in-depth qualitative inquiry of Chinese green finance. It will investigate the issuance of a Chinese green bond by the Chinese bank ICBC in Thailand, and a case of green securitisation by Chinese multilateral bank AIIB in Turkey. These two different financial instruments will shed light on the diversity of green financial regulations and standards in two of the regional environmental/biodiversity hotspots of the BRI corridors: South East Asia and Western Asia. The overall aim of the project is to collect empirical evidence to contribute to the larger process of financialisation of nature in its global and spatial variety.

Keywords: financialisation of nature,green finance,belt and road initiative,china
BoneFix: A Paradigm Shift in Fracture Fixations via On-Site Fabrication of Bone Restoration Patches (BoneFix)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Norway,Sweden,Switzerland,France,Denmark
Call: FET Proactive: emerging paradigms and communities (H2020-EIC-FETPROACT-2019, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 3983468.13
EU funding (EUR): 3983468.13
Participants: 7
Project status: SIGNED

As Europe’s population rapidly ages so too does the socioeconomic cost of bone fractures. According to WHO, the total number of osteoporosis-related fractures in EU patients will rise to 4.5 million in 2025, which translates to 8.5 incidents per minute. Unfortunately, clinically used metal fixators are old-fashion solutions and their rigid design combined with open surgery and general anaesthesia, make them poor fixators for fractures on thin, fragile, inaccessible and shattered bone. Our solution is BoneFix, a novel class of bone adhesives that will allow for personalized surgical treatment of bone fractures via minimal invasive surgery under local anaesthesia. This will be accomplished by developing a novel library of biocompatible, biodegradable triazine monomers, linear polycarbonates and multi-purpose dendritic materials, capable of binding to wet bone, together with strong biodegradable organic/ceramic composites. Building from the bottom up, the concept involves three domains: a bone substitute void filler, topological mechanical fixation patch, and a protective anti-bacterial hydrogel layer. The components will be delivered through narrow gauge needles and solidify “on fracture site” via High Energy Visible Light Off-Stoichiometric Thiol-Ene Coupling chemistry (HEV-OSTEC). Collectively, these will form a Bone Restoration Patch (BRP) - a customizable, universal solution for fractures that upon complete healing will be fully resorbed. The BRPs will be thoroughly evaluated by stakeholders in order to assess relevant properties, both ex vivo and finally in vivo on relevant animal models. The ultimate goal is to cement a new disruptive technology and a paradigm shift in clinical interventions of bone fractures in which BoneFix heals, fixates and protects complex fractures making screws, plates and open surgery obsolete.
Role of Epithelial Apoptotic Force in Morphogenesis (EPAF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 2311843.75
EU funding (EUR): 2311843.75
Participants: 1
Project status: CLOSED

Contrary to previous beliefs, recent studies have suggested that apoptotic cells play an important dynamic role during morphogenesis. Nonetheless, the mechanisms whereby dying cells drive tissue shape modification remain elusive. Using the Drosophila developing leg as a model system to study apoptosis-dependent epithelium folding, we have recently shown that apoptotic cells produce a pulling force through the unexpected maintenance of their adherens junctions that serves as an anchor to an apico-basal Myosin II cable. The resulting apoptotic apico-basal force leads to a non-autonomous increase in tissue tension and apical constriction of surrounding cells, leading to epithelium folding. These results reveal that, far from being passively eliminated as generally thought, dying cells are very active until the end of the apoptotic process. The objective of the present proposal is to understand how apoptotic cells influence their surroundings from the micro-environment to the macro-scale level. Our first aim is to dissect the cellular mechanisms governing the generation of the apoptotic force and its transmission to the tissue, both apically through planar polarity and basally through the extra-cellular matrix (ECM), in parallel with the identification of the network of genes orchestrating apoptosis-dependent morphogenesis through a powerful genetic screen. Interesting preliminary results have already identified the epithelio-mesenchymal-transition gene Snail as essential for the progression of apoptosis, thus validating our approach. Therefore, the second aim of this project is to compare Snail function in the control of adhesion and ECM dynamics and in the generation of tissue tension in both EMT and apoptosis. This original comparative study should bring novel insight into these two fundamental processes. To perform this work, we will use elegant genetic tools combined to state-of-the-art live imaging techniques, together with robust biophysical modelling.

Keywords: cytoskeleton dynamics,cell adhesion dynamics,cell shape dynamics
Modelling Environmental Tax Reform in Spain (METRES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-07-01
End date: 2018-12-31
Duration (months): 30.0
Total project cost (EUR): 199158.6
EU funding (EUR): 199158.6
Participants: 2
Project status: CLOSED

The METRES (Modelling Environmental Tax Reform in Spain) project aims to evaluate the “double dividend hypothesis” for environmental taxation in Spain. To do this, the researcher would develop an Intertemporal General Equilibrium Model (IGEM) to assess the economic and the environmental effects of an Environmental Tax Reform (ETR) and of some of the main environmental taxes in Spain at different administrative levels, as well as various proposed policy reforms. In a first phase of the research project, conducted at Harvard University (United States), the IGEM would be built, and a comprehensive ETR for Spain would be tested through the development of scenarios that consider the reduction of labour taxes in favour of environmental taxes. In a second phase, conducted at the policy-oriented (and research-oriented) consultancy and SME Serveis de Suport a la Gestió, SL (ENT Environment and Management) (Spain), three currently existing environmental taxes in Spain, at three different administrative levels, would be tested in the developed model. After that, one scenario that improves the effects for each tax would be developed. Finally, some policy measures would be proposed, including possible changes to configuration and regulation of the analysed taxes. The three environmental taxes assessed would be: at national level, the tax on electricity; at regional level, the tax on landfill and incineration of waste in Catalonia, and at local level, the vehicle circulation tax. In the first case, taxation on electricity was recently modified and these changes need to be evaluated. In the second case, this municipal solid waste tax at regional level has become a successful case study and has received international attention. Finally, the Spanish Parliament already in 2007 passed a resolution asking for the revision of the local vehicle circulation tax. This methodology is widely used by the US Environmental Protection Agency (EPA) and improves previous existing CGE methods.

Keywords: environmental tax reform,environmental taxation,intertemporal general equilibrium model
Towards climate-smart sustainable management of agricultural soils (EJP SOIL)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: COFUND actions
Partnership: EJP SOIL (EJP-COFUND)
Countries involved: Austria,Estonia,Ireland,Italy,Germany,Germany,Spain,Italy,Italy,Italy,Slovenia,Slovenia,Sweden,Switzerland,Türkiye,Belgium,Norway,Belgium,Belgium,Finland,Hungary,Lithuania,Poland,Slovakia,Latvia,France,France,Czechia,Netherlands,Netherlands,Denmark,United Kingdom,Portugal
Call: European Joint Programme on agricultural soil management (H2020-SFS-2019-1, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 79999999.89
EU funding (EUR): 40000000.0
Participants: 47
Project status: SIGNED

The main objective of EJP SOIL is to create an enabling environment to enhance the contribution of agricultural soils to key societal challenges such as climate change adaptation and mitigation, sustainable agricultural production, ecosystem services provision and prevention and restoration of land and soil degradation. The EJP SOIL will build a sustainable European integrated research community on agricultural soils and will develop and deploy a roadmap on climate-smart sustainable agricultural soil management. The EJP SOIL roadmap is based on a knowledge framework with 4 interacting components. Knowledge development is set out in project calls with internal and external partners. Knowledge sharing & transfer is framed in capacity building for young scientists, enhancing general public awareness and fostering societal understanding and appreciation of agricultural soil management and its contribution to society. Knowledge harmonization, storage & organization supports harmonised soil information and reporting practices. Knowledge application deals with ways to overcome barriers for adoption of novel practices in a European context, co-developing adequate tools and providing evidence-based recommendations for EU policies. EJP SOIL activities in interaction with stakeholders, MSs and DG AGRI will pursue the long-term goal of promoting farmers as stewards of land and soil resources and support policy development and deployment, in particular the CAP and Climate policies. The EJP SOIL addresses 6 expected impacts with targeted activities in response to societal, scientific, policy and operational challenges. A first annual workplan based on the roadmap is provided as part of the proposal. The EJP Soil consortium unites a unique group of 26 leading European research institutes and universities in 24 countries. The consortium has developed this proposal in close collaboration with its programme owners and has secured over 40M€ in co-funding and 10M€ for external calls over 5 years.

Keywords: soil,agriculture,management,climate change,soil quality,data harmonization