Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Settlement and Landscape Organisation of the Persepolis Region (SELOPERSE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 193726.8
EU funding (EUR): 193726.8
Participants: 1
Project status: CLOSED

The SELOPerse project aims to study the ancient Achaemenid occupation in the vicinity of the prestigious Unesco’s classified site of Persepolis (Iran, Fars province), one of the sumptuous royal residences built by King Darius I (520-486 BC). The project based on a new vision of the site organisation scheme as a kind of “garden city”. It means widespread settlement blocks ensuring the administrative and economic functions of what it was a provincial capital and sheltering the numerous inhabitants. The buildings blocks were probably located within a landscaped area of gardens, parks, fields and orchards. Farther in the wide and fertile Persepolis plain the exploitation of the natural resources and cultivation were managed by a network of local administrative centre and farms. Due to the present day human pressure and intensive cultivation the remains of the Achaemenid landscape disappear gradually. Traces of ancient settlements or infrastructures are difficult to find. The only way to study the still preserved remains is to carry out large scale studies by combining multiple survey methods (field walking and geophysical surveys) and excavations on selected points. The multidisciplinary and multiscale approaches will allow to rescue the archaeological information and to demonstrate our renewed hypothesis. The SELOPerse project will be host by the Ravenna department of heritage studies of the University of Bologna (Italy), centre of excellence in archaeology. It will be supervised by Prf. P. Callieri, the Italian co-director of the Iranian Italian excavation and restoration project in Persepolis carried out by a collaborative team. Involved in this multidisciplinary team, I will manage and carry the surveys. As underline by this existed project of the University of Bologna, archaeological cooperation between Italy and Iran is very developed and Italy is an internationally recognized main actor of the Iranian studies and a stimulant research environment in archaeology.

Keywords: humanities,history,archaeology,iran,fars,persepolis,achaemenid,royal residence,settlement,hinterland,city,organisation scheme,survey,field walking,geophysics,magnetic survey,topography
A combined approach of cryo-electron tomography and protein tagging for elucidating the structural organization of the human Nuclear Pore Complex (NPCCRYOET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-12-01
End date: 2014-11-30
Duration (months): 24.0
Total project cost (EUR): 174475.2
EU funding (EUR): 174475.2
Participants: 1
Project status: CLOSED

Nuclear Pore Complexes (NPCs) represent the exclusive passageway in and out of the nucleus but also function in gene regulation and nuclear organization. NPCs serve as docking sites for many viruses and were associated with several human diseases, e.g. leukemia. Understanding the nuclear transport mechanism will have a huge impact on human health research of such diseases. Multiple copies of ~30 different protein components, termed nucleoporins (Nups), form the major building blocks of NPC. Nups are organized as repetitive modules, called subcomplexes. The subcomplexes, in turn, form the scaffold of NPC in an unknown arrangement. Despite their importance, structure determination of NPCs is a considerable challenge, primarily due to their sheer size. To generate an atomic model of the human NPC, data at the different resolution levels have to be systematically collected and integrated. Determining the position of Nup subcomplexes within the NPC will be a critical step to bridge the resolution gap between different structural techniques. Since the precision of 2D-immuno-gold labeling techniques is insufficient to associate individual Nups with distinct features of the NPC structure from cryo-electron tomography (cryo-ET), alternative strategies are needed to achieve this goal. Here I propose to improve the resolution of the human NPC structure to allow assigning subcomplexes into the overall assembly. This will be achieved by cryo-ET, subtomogram averaging and further development of algorithms correcting for NPC plasticity. Furthermore, I will determine the precise positioning of subcomplexes by obtaining 3D structures of NPCs containing tagged Nups. This will contribute significantly to our understanding of the overall organization of the NPC and thus, nuclear tranport mechanism. This proposed project will give me the opportunity to learn new skills, acquire competencies and, thus pave the way towards an independent career.

Keywords: cryo-electron tomography,nuclear pore complex,protein tagging,immune-gold labeling,subtomogram averaging
Development of Multiscale Analysis of Pancreatic Beta-Cell Function by Imaging Islets in situ within the Intact Pancreas (MULTI-ISLET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-03-01
End date: 2014-02-28
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Type 2 diabetes is a global and costly healthcare problem associated with impaired insulin secretion from pancreatic beta-cells as well as peripheral insulin resistance. The range of complications associated with aberrant glucose homeostasis is vast, and some severely impact the ability of diabetes-sufferers to lead a normal life. Despite significant research funding over the past three decades, the incidence of diabetes continues to grow. The finding in recent years that genes predispose to diabetes has ignited a search for the mechanisms through which diabetes-associated genes predispose to diabetes. At the single cell level, gene-silencing/transduction studies using cell cultures have shown that gene polymorphisms consistently associated with diabetes, such as those for TCF7L2, lead to defects in insulin processing, storage and secretion. At the whole-animal level, beta-cell specific deletion of TCF7L2 leads to marked glucose intolerance. Yet, directly extrapolating findings between these two levels is complicated by the dependence of beta-cells on their tissue context for proper function. To overcome this obstacle, and adequately reconcile these observations, further studies are required to assess how type 2 diabetes-associated genes alter beta-cell function at the single cell and population levels in the intact tissue. By applying multiphoton imaging and optogenetics to murine models of type 2 diabetes, new insights into the influence of identified risk genes on beta-cell behavior at multiple levels can be obtained. It is hoped that the findings stemming from these studies will allow new therapeutic targets to be identified in the future.

Keywords: health sciences,endocrinology,diabetology,physiological biophysics
The International Law of Offshore Construction: Cutting Through Fragmented Legal Regimes Towards Better Governance (OFFSHORELAW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-03-01
End date: 2014-04-30
Duration (months): 24.0
Total project cost (EUR): 183805.8
EU funding (EUR): 183805.8
Participants: 1
Project status: CLOSED

Offshore constructions rise in numbers and importance. They promise high economic and scientific benefits, but they also increase risks of accidents and environmental damage. The incident of the offshore oil rig “Deepwater Horizon” in the Gulf of Mexico poignantly illustrates the limits of the existing legal framework that is fragmented along the lines of different geographical areas, different sectors of activities, and, notably, different fields of law. No international treaty specifically deals which the issue and academic research has shown little attention in spite of the multiplication of offshore constructions. The proposed research project intends to fill this gap and wishes to contribute to better ocean governance. More specifically, it aims at clarifying the international legal framework that regulates the life of offshore constructions in order to provide useful legal tools to both private investors and policy makers. The research will start with an analysis of multilateral treaties that do already contain obligations in the fields of environmental protection as well as maritime safety and security. Against this background, it then studies the practice of states both at the regional and bilateral level, placing particular emphasis on the role of the EU and the practice of EU member states. With the Marie Curie Programme, the candidate could carry out her research project at the Netherlands Institute for the Law of the Sea (NILOS) at Utrecht University, one of the very best institutions in her field. The research project would train the candidate and consolidate the development of her academic career in a profound and lasting fashion. Her level of skills and expertise could now be expanded further at NILOS. The candidate would advance towards a senior academic position within 2-5 years upon completing the proposed project.

Keywords: offshore construction,law of the sea,european law,protection of marine environment,renewable energy,eu maritime policy,eu energy policy,eu environmental policy
Comparison of analytic and topological torsion on singular spaces (COMPTORSING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 260758.8
EU funding (EUR): 260758.8
Participants: 1
Project status: CLOSED

The aim of this project is to provide a comparison result between analytic and topological torsion in the presence of singularities. Comparison theorems between analytic and topological torsion on smooth manifolds have been an object of intensive study during the last 40 years in Mathematics. More recently, the study of analytic torsion on singular spaces has gained interest. It is therefore natural to look for its topological counterpart, i.e. the right object on the topological side of the comparison. The idea of this project is to approach the question using the Witten deformation. This approach in the singular context is new and is based on the generalisation of the Witten deformation to singular spaces obtained by the applicant in a series of papers. Ursula Ludwig, the researcher of the proposal, is an expert in the geometry, topology and analysis of singular spaces. Jean-Michel Bismut, the scientist in charge, is one of the world leading experts in local index techniques and questions of analytic and topological torsion. The problem of comparing torsions for singular spaces will be addressed in this project by joining these two competences.

Keywords: geometry,topology and analysis of singular spaces,witten deformation,local index techniques,comparison of analytic and topological torsion
Integrated Risk Governance via Spatial Complexity Inspired Models and Algorithms (IRGSCIMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-06-01
End date: 2015-05-31
Duration (months): 36.0
Total project cost (EUR): 363182.1
EU funding (EUR): 363182.1
Participants: 1
Project status: CLOSED

Based on the concept of Spatial Complexity Inspired Models and Algorithms (SCIMA), this proposed research aims to develop a methodological platform of models and algorithms for the study of Integrated Risk Governance (IRG) problems. The methods to be developed will take into account important spatial and/or temporal features in real-world risk systems, and integrate risk management considerations into the model development stage, in order to develop more effective and efficient tools to analyze risk systems and improve risk management. The overall aim of this study is to, through intensive, systematic training and study of IRG knowledge, develop appropriate SCIMA methods as a natural form of representation for IRG problems that has good compatibility with optimization algorithms. This will be achievable based on two overarching hypotheses: (i) Efficiency, robustness and even intelligence may exist in many natural spatial processes and phenomena, and learning from nature will lead to innovative modelling and algorithms for complex systems such as IRG problems; (ii) Separating the modelling and the design of algorithms in two isolated stages is the main cause of ineffectiveness and inefficiency in the optimization of complex systems, and therefore incorporating the compatibility to optimization algorithms into the modelling stage of complex systems may bring ground breaking results. Under the above two hypotheses, the proposed study has two major research themes. One is, inspired by natural ripple-spreading phenomenon, to design some problem-specific RSMA methods for some risk systems, the other is a spatial extension of temporal RHC to develop an more effective risk management strategy in terms of optimality and scalability. They are two distinct yet complementary strands to this proposal.

Keywords: environmental science,computational models,modelling networks,algorithms
NAnomics in vitro DEvelopmental TOXcology (NADETOX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-19
End date: 2014-10-18
Duration (months): 24.0
Total project cost (EUR): 183805.8
EU funding (EUR): 183805.8
Participants: 1
Project status: CLOSED

The progress made in improving the development and the production of nanoparticles (NPs) is enormous. Metallic nanoparticles (mNPs) are among the most widely used types of NPs in electronics, foods, containers, pharmaceutical drugs, cosmetics and paints. This trend will lead to an ever-increasing presence of NPs in the environment. This scenario means that humans and the environment will be exposed to more and more nanotechnology-based products whose health risks and environmental impacts of NPs might outweigh their benefits. In order to promote prevention and safety in manufacturing and handling of NPs, NADETOX aims at evaluating the nanodevelopmental toxicity of selected metallic cobalt, silver and gold NPs extensively used in nanomedicine for cancer therapy. This novel and multidisciplinary research project is based on the 3Rs in vitro approach (Reduction, Refinement, Replacement), involving the development of a mechanistically-based alternative method, Frog Embryo Teratogenesis Assay-Xenopus (FETAX), and the combined use of peculiar advanced spectrochemical, radioanalytical, biochemical and molecular biology techniques. These methods offer the opportunity to label NPs, avoiding surface modification, to localise and quantify them in organisms. NADETOX aims at the following goals: (i) characterisation of NPs establishing their size and morphology, (ii) study of stability and of the eventual release of metal ions from radiolabelled NPs in the reconstituted water medium suitable for the culture of Xenopus embryos (FETAX medium), (iii) evaluation of embryolethality and teratogenicity of NPs by FETAX assay, (iv) biokinetics studies to measure uptake, metabolic fate and biopersistence of NPs in Xenopus at embryo and larva stages and structure diagnosis at DNA level, to get information on the genomic stability following formation of DNA-adducts.

Keywords: manufactured nanoparticles,nanotoxicology,developmental toxicology,embryotoxicity,teratogenicity,toxicokinetics,3rs,in vitro alternative methods,xenopus,fetax,radioanalytical methods
Chemical AMPylomics: targeting a novel host-pathogen interaction (CHEMAMP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

In 2009 protein AMPylation, the reversible post-translational adenylation of target proteins with adenosine monophosphate (AMP), was first revealed as a novel mechanism for pathogenic bacteria to target and disrupt interactions of host GTPases with their cognate binding partners. Furthermore, there is growing evidence that AMPylation also operates as a general intracellular signaling mechanism in normal cell function. This novel post-translational modification is catalyzed by AMP transferases containing a so-called Fido motif that has been found across prokaryotes and eukaryotes, in over 2700 putative bacterial and mammalian proteins. Consequently, AMPylation is rapidly emerging as a fundamental mechanism to regulate protein-protein interactions and cell signaling in normal cells and in host-pathogen interactions, providing an opportunity for the discovery of new biology and targets for new antibiotics with novel mode of action. However, without robust tools to identify and manipulate both AMP transferases and their AMPylated protein substrates, our understanding of this complex signaling network will remain superficial. This Fellowship project aims to develop and apply chemical probes and technologies that will enable for the first time high-throughput analysis and exploration of the complex biological networks involved in protein AMPylation. These chemical tools will be applied to mapping the changes in AMPylation that occur during bacterial infection in the host and the pathogen, with the ultimate objective of identifying and validating cellular mechanisms that can be targeted for future antimicrobial therapy.

Keywords: post-translational modifications,chemical proteomics,activity-based probes,ampylation,host-pathogen interactions,antimicrobial therapy
Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases (D-BOARD)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,Belgium,Netherlands,Netherlands,Germany,Israel,Hungary,Netherlands,Germany,United Kingdom,Denmark,Denmark
Call:  (FP7-HEALTH-2012-INNOVATION-1, 2012)
Start date: 2012-10-01
End date: 2017-09-30
Duration (months): 60.0
Total project cost (EUR): 7982003.41
EU funding (EUR): 5993459.09
Participants: 15
Project status: CLOSED

Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in joint space width (JSW). However, radiographic evidence is seen only after significant cartilage degradation has already taken place. The early stages of the disease may remain latent and asymptomatic for many years. Therefore, there is an acute need for reliable biomarkers and diagnostic tests that can facilitate earlier diagnosis of OA, and inform the prognosis, monitoring and therapeutic strategies for chronic and disabling forms of this disease. However, there is currently a lack of reliable, quantifiable and easily measured biomarkers that provide an earlier diagnosis of OA, inform on the prognostic of the disease and monitor and predict responses to therapeutic modalities. Biomarkers of tissue turnover in joints can reflect disease relevant biological activity and provide valuable information that may be useful diagnostically and therapeutically, potentially enabling a more rational and personalized approach to healthcare management. The proliferation of omic technologies has facilitated rapid progress in biomarker research. Combinations of omic technologies are dominating the biomarker research arena and are playing increasingly important roles in the identification, validation and qualification of new biomarkers. The aim of the D-BOARD consortium is to bring together leading academic institutions and European Small and Medium Enterprises (SMEs) to focus on the identification, validation and qualification of new combination biomarkers and the development of diagnostic tests capable of subclinical disease diagnosis for degenerative and inflammatory diseases of joints.

Keywords: osteoarthritis,ageing,early diagnosis,biomarker,combination biomarkers,aggregate biomarkers,imaging,proteomics,genomics,lipidomics,metabolomics,bioinformatics,data modelling,immunoassays