Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SPARC –Sustainable Parasite Control in Grazing Ruminants (SPARC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Belgium,Italy,Spain,Poland,France,Germany,United Kingdom,Greece,Netherlands,Ireland
Call: Thematic networks to compile and share knowledge ready for practice (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 2673154.56
EU funding (EUR): 2538181.88
Participants: 15
Project status: SIGNED

Ruminant farming is critically important in maintaining the viability of rural communities and ensuring food security. Because grazing ruminants are permanently exposed to helminth parasites, efficient worm control is a requirement to guarantee their health, welfare and productivity. Worm control is largely based on preventive use of anthelmintic drugs, but excessive use of anthelmintics has led to anthelmintic resistance, which has become a global threat for effective parasite control. To mitigate anthelmintic resistance in ruminants, sustainable worm control (SWC) strategies should be adopted. The SPARC Community of Practice of farmers, farm advisors and veterinarians will identify needs, practices, barriers and drivers for adoption of SWC practices, develop a list of good practices for SWC in different production systems and regions and demonstrate them on pilot farms. National and international stakeholder networks will share SWC practices among farmers, across borders and production systems (beef and dairy cattle, meet and milk sheep and goats). Dissemination of experiences and results will be facilitated by a Knowledge Exchange Platform on the SPARC website, hosting testimonies, case studies, videos, practice abstracts and decision support tools, available in local languages. SPARC activities and results will be communicated on social media and in professional journals. Overall, SPARC will initiate a lasting European-wide multi-actor community that develops solutions together to curb anthelmintic resistance, aiding in the green transition of European agriculture.

Keywords: parasites,resistance,network,ruminants,grazing,sustainability,control
HARMONISED NUTRIENT LOAD REDUCTION APPROACHES WITHIN SAFE ECOLOGICAL BOUNDARIES IN CATCHMENTS LOCATED IN NW EU (NEW-HARMONICA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Coordination and support actions
Countries involved: Netherlands,United Kingdom,Belgium
Call: Regional nitrogen and phosphorus load reduction approach within safe ecological boundaries (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 4
Project status: SIGNED

In 2015, the ecological status of 75-90% of surface waters in NW Europe was reported to be less than good. Diffuse pollution with nitrogen (N) and phosphorus (P) from agriculture, together with point sources of N and P pollution from wastewater plants and industry, are a major cause of this failure to achieve good ecological status. Climate change is likely to exacerbate the pollution risk. Clearly, there is a huge challenge to implement effective mitigation measures to reduce nutrient loadings to air and water to meet desired environmental targets against the background of a changing climate. The synergies and tradeoffs between management actions to mitigate climate change and those to mitigate N and P pollution need to be clarified to develop effective local, regional and national policies. Governance arrangements to implement and monitor the necessary actions need to be better integrated, requiring a consistent and coherent set of environmental indicators. The overall objective of NEW-HARMONICA is to assess and co-develop a harmonised systemic approach to prioritizing an effective suite of N and P pollution mitigation measures and indicators to meet local to regional environmental targets. To achieve this objective, an experienced NEW-HARMONICA consortium (4 partners from 3 countries) with complementary expertise, skills and networks will work on 4 N and P-polluted cross-border river basins in NW Europe. All partners are involved in an established NW Europe Policy-Science Working Group (PSWG) who together with local catchment stakeholders play a central role in NEW-HARMONICA. NEW-HARMONICA’s approach is based on a combination of technical assessments, including quantification of N and P flows and load-reduction targets in the study catchments, assessments of governance arrangements, and policy support for the co-development of harmonised environmental policies, based on a strong evidence base and interactions with the PSWG and local stakeholders.
Nanobodies to prevent hematopoietic stem cell bias and hyper-inflammation. (UNBIAS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-08-01
End date: 2025-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

With a growing ageing population, there is an imminent demand to develop new therapeutic strategies to ameliorate disorders of the hematopoietic system. Our innate immune system can remember its previous encounters with inflammatory triggers. Epigenetic memories of previous inflammatory experiences throughout an individual's lifetime are imprinted in hematopoietic stem cells (HSCs), a small pool of bone marrow progenitors that give rise to all our blood cells. Inflammation harms HSCs causing their functional decline and premature ageing. It also causes long-term differentiation bias, and a heightened basal inflammatory status, known as “inlfammageing”. The most striking characteristic of aged HSCs is their increased expression of platelet and megakaryocyte markers and their commitment towards platelet biogenesis, referred to as “Platelet-bias." Platelet bias has important consequences to human health. In our ERC starting grant project PLAT-IL-1 (714175), we discovered that platelets boost the inflammatory capacity of innate immune cells and are essential for the cytokine production of human monocytes. Our findings support that a dangerous combination of myeloid and platelet bias in inflammation-exposed HSCst results in a heightened innate immune activation. The injuries to HSCs are persistent and continue even after the clearance of the inflammatory insult, indicating that remnants of inflammatory events accrue and prolong damage to HSCs. Hence, if we could “erase" these harmful remnants, we could UNBIAS HSCs differentiation and prevent hyper-inflammation. In our ERC-funded project, we developed novel nanobodies that efficiently eliminate remnants of inflammation in vivo. In this PoC project, we will test the ability of nanobodies to erase memories from previous inflammatory events and prevent hyper-inflammation. This project will be a stepping stone to licensing our nanobodies to industrial partners.
An innovative non-contact and harmless screening modality set to change the course of breast cancer detection and patient monitoring (ThermoBreast)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Lithuania,Israel,Ireland,Germany,Slovenia,Switzerland,Netherlands,Belgium,France,Italy,United States
Call: Develop new methods and technologies for cancer screening and early detection (HORIZON-MISS-2021-CANCER-02, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 11432044.75
EU funding (EUR): 11432043.75
Participants: 17
Project status: TERMINATED

Female breast cancer is the most diagnosed cancer worldwide. In 2020, the International Agency for Research on Cancer estimated more than 2.26 million new cases of breast cancer. Early detection is crucial to survival; recovery rates approach 90% when detected in early stages. National population-based cancer screening programmes in Europe currently implement 3 standard imaging modalities: mammography, ultrasound and MRI. The downsides of these screening methods include ionising radiation, high costs and high false positive rates in screening results. Our multidisciplinary consortium of 16 partners from 10 countries aims to contribute to EU’s Mission on Cancer and Beating Cancer Plan by drastically improving the prevention, diagnosis and monitoring of breast cancer while reducing the burden on women and female patients and their families, health care professionals and others who are directly or indirectly affected by breast cancer. ThermoBreast proposes a new solution for accurate, harmless and non-contact screening, equally applicable for all age groups and breast densities and capable of detecting pre-cancerous states. This risk-free screening technology, recently patented by the project coordinator ThermoMind LTD, can detect vascular anomalies and asymmetry, caused by cancerous growth. It combines innovative screening through multiple sensitive infrared sensors with advanced AI analysis of temporal dynamic thermal patterns. Through its patient-centred integrated diagnostics approach, this project converges intelligent computer vision, blood vessel extraction and tissue analysis with advanced information technology to deliver a medical class 1 device that will be validated in an international multicentre clinical study. To enhance stakeholder participation, ThermoBreast involves end users, SSH experts and a patient organisation in the co-creation of the new screening solution and assesses its health and socio-economic benefits as well as its cost effectiveness. This action is part of the Cancer Mission cluster of projects on ‘Prevention, including Screening’.

Keywords: dynamic thermography,breast cancer screening,early detection,computer vision,vessel map extraction,thermal patterns
Fluidic Shaping of Optical Components on Earth and in Space (Fluidic Shaping)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 2340000.0
EU funding (EUR): 2340000.0
Participants: 1
Project status: SIGNED

We propose to develop and demonstrate a new concept that leverages the fundamental physics of interfacial phenomena to rapidly fabricate complex optical components of any size (from millimeters to meters) with sub-nanometer surface roughness, without the need for any mechanical processing such as grinding or polishing. We term our approach ‘Fluidic Shaping’ to describe its core principle – the ability to take a volume of liquid, shape it into a desired form, and finally cure it to obtain a solid object. The method relies on negating gravitational forces that act on the liquid, which we achieve on Earth using buoyancy forces, and which can be naturally achieved in space flight. By dictating the boundary conditions of the liquid, we vary the minimum energy state of the system, and drive the liquid interface into a desired shape. The proposed project is composed of five main aims: (1) development of a theoretical framework that would describe the range of optical surfaces that could be produced and provide engineering guidelines for the rest of the project, (2) development of a stand-alone device for fabrication of high quality corrective lenses, (3) development of methods for fabrication of high precision optics, and expansion of the range of materials that could be used, (4) demonstration of in-space manufacturing of optical components, and (5) development of approaches for deployment of very large (meters) fluidic lenses. These aims serve to put in place the basic and foundational knowledge that could enable transformative changes in multiple fields: (a) rapid prototyping of optical components – by enabling fabrication of custom, high precision optics in minutes, (b) access to corrective eyewear in low resource settings – by enabling fabrication of quality lenses without heavy infrastructure, (c) space exploration – by enabling in-space manufacturing of optics, and (d) astronomy – by enabling large space telescopes that overcome current launch constraints.

Keywords: interfacial phenomena,optical components,microgravity,hydrostatics,freeform optics,lenses,rapid prototyping,in space manufacturing,space telescopes
Enhanced silicate weathering in agricultural rice paddies: maximisation of soil carbon sequestration and crop production, while reducing the overall greenhouse gas emissions (EWRECA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

In order to limit global warming to the well below 2°C of the United Nations’ Paris Agreement, model projections indicate that both rapid decarbonisation and the implementation of negative emission technologies (NETs) that ensure long-term stable carbon (C) sequestration will be required. Among NETs, enhanced weathering (EW) of silicate rocks can remove CO2 from the atmosphere, while potentially delivering co-benefits for agriculture (e.g. reduced nitrogen losses, increased yields, increased drought and salinity resistance) and reducing the overall greenhouse gas (GHG) emissions from this activity. Thus, EW application may be of special interest on rice paddies since they: emit large quantities of methane (up to 11 % of global CH4 emitted); have high water demands and might face drought episodes due to climate change; and are exposed to salinity stress in Europe since they are cultivated in coastal areas. Although some studies have studied the effects of silicate waste on rice paddies, none of them have combined natural silicate rocks and waste simultaneously. Moreover, quantification of inorganic C sequestration through EW and the potential risks in terms of heavy metal contamination have rarely been assessed. The main goal of EWRECA is to develop an agricultural management practice for rice paddies that (i) minimises the GHG emissions, while maximising (ii) rice production (biomass and quality), and (iii) C sequestration. Moreover, EWRECA aims to re-use crushed concrete fines, an artificial silicate from construction waste, thus enhancing material circular economy. To achieve this objective, a mesocosm field experiment will be set up applying different agricultural management treatments. Responses on GHG emissions, plant biomass and soil microbial communities will be assessed over two growing seasons. Overall, this project will generate valuable scientific results that will be of interest for national, European and global strategic actions in agricultural systems.

Keywords: enhanced weathering,greenhouse gas emissions,soil carbon sequestration,sustainable agriculture,microbial communities,circular economy
Lifetime Metabolomics for Paediatric Liver Cancer Detection and Therapy Assessment Using Organ-on-Chip Platforms (LIFETIME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2499318.0
EU funding (EUR): 2499318.0
Participants: 1
Project status: SIGNED

Understanding cancer metabolism at the individual patient level is central to making accurate early-stage diagnoses and providing effective patient-specific treatments. While some methods do exist to study intra-cell metabolomics and inter-cell metabolic flux alterations (e.g., PET, MRI), their scalability and sensitivity is limited, hindering reliable investigations long-term. LIFETIME aims to develop a single platform for "lifetime metabolomics", where the metabolic fingerprint of a disease is traced throughout patient onset in vivo, analysis ex vivo, and through to treatment. Technologically this involves rapid metabolomic profiling of the cancer model, using microfluidic 3D-cell-cultures in organ-on-chip (OoC) structures and magnetic resonance spectroscopic imaging (MRSI). Scientifically, the disease-specific case study chosen is hepatoblastoma (HB), the most common liver cancer in children, where the platform could improve patient survival rate and quality of life. Metabolic contrast in three phenotypes of HB mouse models (intrahepatic, intravenous, subcutaneous) and their OoC counterparts will be assessed. A unique benefit of the platform will be its capability for parallel, repeatable measurements on samples to track therapeutic-induced metabolic alterations over time. This will unveil tumours' detailed molecular phenotypes and shed light on their correlation with tumour heterogeneity and interactions within tumour microenvironment. Overall, LIFETIME will enable the definition of new reliable biomarkers of HB that propel the development of targeted therapies. If successful, the scalability of the platform will hold the important ability to bridge in vivo and in vitro assessment, from biopsy-derived cell cultures (parallelised screening) to patients (correlating with current clinical MRSI). Long term, LIFETIME will empower assessment of the benefits and constraints of OoC technology in cancer and other aggressive disease research.

Keywords: hyperpolarization,mri,organ on chip,spectrometry,imaging tools,metabolic sensors,parallelised detection
Spatial miRNomics in Glioblastoma: Mapping the Unseen and its Clinical Significance (Spatial miRNomics)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-16
End date: 2028-03-15
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

Glioblastoma is the most common and aggressive brain tumour, with an 85% mortality rate within two years of diagnosis. In Europe, tens of thousands of people die from glioblastoma every year, and currently there are no effective treatments. Glioblastoma tumours exhibit high genetic and phenotypic heterogeneity with numerous cancer subclones. This complexity complicates the identification of useful clinical features across patients, highlighting the importance of studying glioblastoma from the perspective of its heterogeneity. MicroRNAs are small, non-coding RNA molecules that regulate gene expression post-transcriptionally. They play an important role in glioblastoma, where their dysregulation can drive tumour development. In addition, microRNAs hold potential as biomarkers, with the unique duality of acting both as targetable molecules and deliverable drugs, offering new opportunities for diagnosis and treatment. However, to date, no imaging method has achieved multiplexed mapping of microRNAs in tissues, resulting in a gap in understanding their spatial distribution within key tumour regions and how they contribute to glioblastoma heterogeneity. Spatial miRNomics is a pioneering concept that will, for the first time, map the spatial distribution of microRNAs in single cells and across glioblastoma tissues. Funded by the Marie Skłodowska-Curie Actions, Spatial miRNomics will extend spatial biology to microRNAs to close that gap, revealing their landscape in brain tissues, and their clinical significance in glioblastoma. This multidisciplinary effort will be performed at Mats Nilsson's Group (Stockholms Universitet), pioneers in spatial biology, and conducted at SciLifeLab, in the Karolinska Science Park. SciLifeLab excels in spatial omics with strong research, clinical and industrial collaborations and exceptional infrastructures. Aligned with the European Cancer Mission, Spatial miRNomics aims to strengthen European leadership in health innovation.

Keywords: micrornas spatial biology spatial transcriptomics in situ sequencing gene regulation brain cancer glioblastoma