Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Strength Bearing for Large-Bore LEAD FREE Engines (BeLEADFREE)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Spain,Belgium,United Kingdom,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 3908690.0
EU funding (EUR): 2963412.88
Participants: 5
Project status: CLOSED

Lead (Pb) is a heavy metal very harmful to health and the environment. Lead is particularly harmful to children resulting in 600,000 new cases of children with intellectual disabilities every year due to Lead exposure. Cost-benefit analysis suggests that, in France alone, overall benefit of €22.72 billion/year could be achieved in terms of avoiding future medical interventions, limiting the need for special education and increasing future productivity by reducing Lead exposure. The European Commission has been working on reducing Lead exposure in different areas. Despite this, the large-bore engine industry still heavily relies on Lead-based journal bearings. 7 tonnes of Lead will be released to the environment from large-bore engines manufactured in 2015. This amount of Lead would be enough to potentially poison 2 times the global population. BeLEADFREE aims to deliver novel Lead-free journal bearings to large-bore engine builders worldwide, ranging from medium and heavy-duty diesel engines (e.g. commercial road vehicles) to large four-stroke medium-speed engines (e.g. ships, engine generators or gensets). This will be achieved by optimising novel manufacturing approaches that have proven successful at TRL6 and designing and building a pilot line to manufacture Lead-free journal bearings to be validated in real engine working conditions. The completion of the project will ensure the initial market take-up of the new product and its implementation in manufacturing businesses in EU. The proposed project will be conducted by a multidisciplinary consortium with two industrial partners, Daido Industrial Bearings Europe Ltd. (1st time industry applicant and project co-ordinator) and Elsyca NV (SME), who will be supported by academic partners IK4-Tekniker and Coventry University who have a strong experience in applied research and knowledge transfer from Academia to Industry.

Keywords: engines,journal bearings,lead free,environmental impact,eco toxicological impact,high strength,enhanced performance,market introduction,pilot line,product validation
Controlling and resolving rotational quantum states in a molecule-surface collision: Matter-wave magnetic interference experiments with ground state molecules. (Rotational Waves)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-08-01
End date: 2024-01-31
Duration (months): 66.0
Total project cost (EUR): 2230400.0
EU funding (EUR): 2230400.0
Participants: 1
Project status: SIGNED

The interaction between a molecule and a solid surface is fundamental to a huge variety of research fields and applications, ranging from industrial heterogeneous catalysis and atmospheric chemistry on ice particles, to ultra-cold astrochemical reactions on cosmic dust. One molecular property that is essential for molecule surface interactions, but also particularly difficult to control and resolve, is the orientation & alignment of the rotational axis of the molecule i.e. the quantum rotation projection states. The existing paradigm is that control over this molecular property can be obtained either by photo-excitation schemes and/or by deflecting experiments using strong electric or magnetic fields. Using these approaches valuable insight was obtained, and the crucial role the rotation projection states have on the outcome of molecule-surface collision was demonstrated. However, the two approaches mentioned above can only be applied to a very small sub-group of systems, (typically on excited/paramagnetic species). Here, we propose a completely different approach which utilizes the rotational magnetic moment, which is a general molecular property, to control and resolve the projection rotation states of ground-state molecules. Our matter-wave approach involves passing a molecular beam through a specific series of magnetic fields, where the different wave components interfere and produce Rabi-oscillations characteristic of the molecular wave function before and after scattering. We present proof-of-principle results demonstrating the validity of our general approach, and describe the novel molecular interference and molecular spin echo measurements we will perform to obtain the much-awaited experimental benchmarks in this field.

Keywords: molecular beams,magnetic manipulations,reactions at surfaces,surface dynamics
Inorganic therapeutic nanoparticles for osteoporosis (INTO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The aim of the proposed interdisciplinary project is to design, make and test novel nanoparticles that will have direct and rapid impact in osteoporosis. The unique aspect of these injectable nanoparticles is that they will deliver active therapy locally, to where it is needed, and that the cargo is not a conventional drug, but a sustained delivery of a combination of active inorganic cations and rare earth nanoparticles. Certain cations can promote bone growth and inhibit resorption and nanoceria can scavenge free radicals that would otherwise accelerate osteoporosis. Systemic concentrations of active agents will be much smaller that caused by taking oral drugs. Delivery will be sustained because it is controlled by the dissolution rate of biodegradable mesoporous silica nanoparticles, which will improve over biodegradable polymer capsules that often deliver a burst release of their drug cargo. Beyond the project, long-term impact could include slowing metastasis of tumours into bone (e.g. breast cancer to the sternum). The biodegradable mesoporous silica nanoparticles will be synthesised by sol-gel, while the nanoceria will be synthesized by co-precipitation method and microwave treatment and entrapped within the silica network. Key aspects will be: incorporation of active ions and nanoceria within monodispersed silica nanoparticles of controlled size; ensuring the particles remain dispersed in body fluid (control of surface chemistry); testing efficacy in cell co-culture (uptake and cell stimulation) and investigating the effect of the presence of the particles on immune cells. The effect of process variables on composition, particle size, bioactivity, degradation rate, radical scavenger ability and the cellular response will be investigated.

Keywords: rare earth nanoparticles,osteoporosis,radical scavengers,mesoporous silica nanoparticles
Water - Sustainable Point-Of-Use Treatment Technologies (WATERSPOUTT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Ireland,Ireland,Ethiopia,Uganda,South Africa,Austria,Spain,Italy,Ireland,Switzerland,Türkiye,Netherlands,United Kingdom,United Kingdom,Malawi
Call: Development of water supply and sanitation technology, systems and tools, and/or methodologies (H2020-WATER-2015-two-stage, 2015)
Start date: 2016-06-01
End date: 2020-05-31
Duration (months): 48.0
Total project cost (EUR): 3571945.83
EU funding (EUR): 3084351.25
Participants: 18
Project status: CLOSED

The WHO estimates that in 2015 in Africa ~156 million people relied on untreated sources for their drinking water. WATERSPOUTT will design, develop, pilot and field-test a range of, sustainable point-of-use solar disinfection (SODIS) technologies that will provide affordable access to safe water to remote and vulnerable communities in Africa and elsewhere. These novel large-volume water treatment SODIS technologies will be developed in collaboration and consultation with the end-users, and include: 1. HARVESTED RAINWATER SODIS SYSTEMS for domestic and community use. (South Africa, Uganda). 2. TRANSPARENT 20L SODIS JERRYCANS. (Ethiopia) 3. COMBINED 20L SODIS/CERAMIC POT FILTRATION SYSTEMS. (Malawi) These are novel technologies that will create employment and economic benefits for citizens in both the EU and resource-poor nations. WATERSPOUTT will use social science strategies to: a. Build integrated understanding of the social, political & economic context of water use & needs of specific communities. b. Examine the effect of gender relations on uptake of SODIS technologies. c. Explore the relevant governance practices and decision-making capacity at local, national and international level that impact upon the use of integrated solar technologies for point-of-use drinking water treatment. d. Determine the feasibility & challenges faced at household, community, regional and national level for the adoption of integrated solar technologies for point-of-use drinking water treatment. WATERSPOUTT will transform access to safe drinking water through integrated social sciences, education & solar technologies, thus improving health, survival, societal well-being & economic growth in African developing countries. These goals will be achieved by completing health impact studies of these technologies among end-user communities in Africa. Many of the consortium team have worked for more than 15 years on SODIS research in collaboration with African partners.

Keywords: solar disinfection ethiopia south africa malawi uganda
Regulation of bone metastases by age-associated angiocrine signals (METANICHE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1496613.0
EU funding (EUR): 1496613.0
Participants: 1
Project status: SIGNED

Blood vessels form a versatile transport network and provide inductive signals called angiocrine factors to regulate tissue-specific functions. Blood vessels in bone are heterogeneous with distinct capillary subtypes that exhibit remarkable alterations with age. Bone is the most prevalent site of metastasis, and ageing is linked to the reactivation of dormant tumor cells (dorTCs) and metastatic relapse. Bone remodeling processes are also associated with metastatic relapse. Here, I will define the role of distinct vascular niches in regulating the fate of DTCs in bone. Finally, I will unravel the age-related angiocrine factors and identify key angiocrine signals that drive the reactivation of dorTCs. I will employ a powerful combination of advanced 3D, intravital, and whole body imaging, cell specific-inducible mouse genetics, transcriptional profiling and bioinformatics in an unprecedented manner to achieve my goals. New cutting-edge techniques such as advanced 3D and 4D bone imaging are important aspects of my proposal. I will also define the role of highly promising novel candidate age-related angiocrine signals with sophisticated inducible endothelial-specific humanised mouse models. My work will break new ground by unraveling a repertoire of age-related angiocrine factors and will contribute to a wider scientific community in bone, blood, and age-related diseases. This interdisciplinary work at the frontiers of bone, cancer and vascular biology will provide the first conceptual link between vascular ageing and bone metastasis and will contribute towards the development of therapeutic strategies for targeting DTCs in bone.

Keywords: bone angiogenesis,angiocrine factors,bone marrow microenvironment,metastatic relapse
Fracture mechanics testing of irradiated RPV steels by means of sub-sized specimens (FRACTESUS) (FRACTESUS)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Spain,Lithuania,Slovakia,Switzerland,Finland,Hungary,Belgium,France,France,Czechia,United States,Netherlands,United Kingdom,United Kingdom,Canada,United Kingdom,Japan
Call: Innovation for Generation II and III reactors (NFRP-2019-2020, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 4666061.25
EU funding (EUR): 2986814.61
Participants: 23
Project status: SIGNED

Fracture mechanics testing of irradiated RPV steels by means of sub-sized specimens (FRACTESUS). The European Union has defined clear short and long term objectives to achieve its energy transition towards sustainable energy and climate neutral economy by 2050. The success of this transition relies on the combination of energy efficiency and low carbon energy in all sectors of the economy. In particular, the industry and transport sector will need to rely more heavily on electricity to achieve this goal. In all electricity mix scenarios up to 2050, one needs to rely on one or a combination of existing nuclear power plants, long term operation, new nuclear build and future nuclear systems. Safety and operability of any nuclear systems heavily relies on a defense in depth strategy where the integrity of structural material plays an essential role. Due to material availability and/or irradiation constraints, the use of small size specimen to obtain reliable measurement of the resistance to fracture is needed by the nuclear industry to comply with the amended Nuclear Safety Directive. Small size specimen fracture toughness measurement has already been shown possible. However, some effort is still requested to achieve European regulatory acceptance of this approach. The goal of this project is to join European and International effort to establish the foundation of small specimen fracture toughness validation and demonstration to achieve change in code and standards allowing to address the various national regulatory authority concerns. FRACTESUS is involving in a very early stage regulatory bodies, code and standardization committee, the industry and the international community in order for the consortium to optimize available resources and expertise.

Keywords: miniaturisation,fracture mechanics
Weight Maintenance by AgRP neurons (Yoyo-LepReSens)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1999976.0
EU funding (EUR): 1999976.0
Participants: 1
Project status: SIGNED

Obesity and its comorbid sequelae are major health burdens across European nations. Many citizens would greatly benefit from permanent weight loss, but only a few succeed. They rather suffer from weight regain after dieting, often referred to as Yoyo effect. Delineating the largely unexplored, CNS-driven molecular events that impede sustainable weight loss and drive the Yoyo effect is a prerequisite for future therapies, and a major goal of my proposal. Recently, my lab demonstrated unprecedented weight loss in diet-induced obese mice treated with the plant-derived leptin sensitizer celastrol. Our data suggested breakthrough potential for therapeutic anti-obesity strategies built upon leptin re-sensitization, and pointed towards a key role for orexigenic circuitry and AgRP neurons residing in the hypothalamic arcuate nucleus. As 1st objective, we will 1) establish if leptin resistance originates in AgRP neurons, 2) delineate the molecular underpinnings of leptin resistance and leptin resensitization in AgRP neurons, 3) verify novel drug-able leptin signalling components in murine and human iPSC-derived cells and 4) identify leptin sensitizing weight loss drugs. AgRP neurons will also be in the focus of my 2nd objective that targets epigenetic mechanisms of Yoyo dieting. Building upon our own data on epigenetic mechanisms that drive weight re-gain through hyperphagia, we will 1) establish if an epigenetic memory for obesity in AgRP neurons exists, 2) explore by Crispr-Cas9-based trans-epigenetic modulation of AgRP neurons in mice whether resetting the epigenetic memory for obesity can prevent weight regain and 3) demonstrate the human relevance of our new weight regulatory genes in post-mortem human hypothalami of lean, obese or type 2 diabetic donors. Overall, my proposal will establish hypothalamic AgRP neurons as crucial drivers for leptin resistance and Yoyo dieting. My translational aims are further providing the groundwork for future anti-obesity therapeutics.

Keywords: obesity,weight loss,yoyo dieting,epigenetics,hypothalamus,agrp,leptin
Next-Generation Quantum Light-Matter Interfaces based on Atom Arrays and Nanophotonic Waveguides (LuMiNouS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

The fellow will investigate the use of atom arrays as next-generation quantum light-matter interfaces. He will be hosted by the Institute of Photonic Sciences in Barcelona, Spain. At ICFO, he will be integrated in the Theoretical Quantum-Nano Physics group under the supervision of Prof. Darrick Chang. Quantum atom-light interfaces have the potential to significantly impact all four domains of Quantum Computation, Communication, Metrology, and Simulation prioritized by the European Quantum Technologies Roadmap. All these future quantum technologies require the ability to efficiently interface light and matter at the level of single quanta. However, despite decades of research in quantum optics, current light-matter interfaces still struggle to meet this requirement at the level needed for robust applications. LuMiNouS is a multidisciplinary, theoretical study of a novel approach based on one-dimensional subwavelength arrays of atoms near nanophotonic waveguides, which are now becoming available experimentally. We aim to show that the spatial ordering and low dimensionality give rise to powerful, previously unexploited interference effects. This new paradigm promises exponential improvements in the fidelity of quantum information processing protocols. LuMiNouS on one hand aims to develop novel protocols with dramatically better error scalings than currently known approaches, and on the other hand will remove the disconnect between theory and experiment by understanding and exploiting real-world complexities. To reach the first objective, we will, in particular, focus on using atom arrays to significantly improve the performance of quantum repeaters, and on realizing high-fidelity interactions between individual photons, a prerequisite for realizing coherent photon-photon gates. Our efforts towards the second objective will be focused on mitigating imperfect lattice filling, and exploiting the atoms' quantized motion as a powerful, previously untapped resource.

Keywords: subwavelength atom arrays
Unique technology to turn on-site paper waste from the printing industry into high-quality PHA bioplastic (PAPER-P)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-09-01
End date: 2016-11-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

PAPER-P is a novel technology to synthetize very high quality PHA bio-plastics (98% purity) from on-site paper waste. Through an extremely cost-effective process, PAPER-P is the unique technology able to use as rough material printed waste, waste solvent and ink, with a price of €0.1/Kg, and transform it into PHA, a 60 times more valuable product worth €6/Kg, thus quadruplicating printers’ ROI, from current 2-8% up to 30%.Thanks to Mr. Giacomelli, CEO of BIO-PRO with more than 27 years of experience in the sector, this Italian SMS has developed PAPER-P in collaboration with Bologna University, as a strategic approach to find new markets for the printing industry, currently experiencing a severe decline.European PHA packaging market is forecasted to reach €25 million by 2018, the highest among bioplastics, with an impressive 25% growth. By contrast, PHA production in Europe is marginal in a global market dominated by China and US (90%).BIO-PRO has developed a tested a TRL6 prototype plant processing 400 kg/year of paper waste. Full integration & automation (turn-key), and upscale to industrial rates (4,000 ton/year) are next steps of project development to TRL9.We have the support from our main key stakeholders: Coptip IndustrieGrafiche (printer), Softer Group (plastic compounder), Loacker SpA (food sector) and COOP Italy (large retailer).BIO-PRO revenue will be increased to €16.5 million with accumulative profit of €3.8 million in 2021. BIO-PRO will incorporate at least 8 new employers. At the same time, PAPER-P will increase 30% the ROI of its first end-users, printing industries, but non-recyclable paper (greasy paper or already recycled paper with short fibbers), can also be converted in PHA by PAPER-P, so the recycler’s sector is a second big potential market that BIO-PRO intends to address in the middle term (in about 10 years), when regulatory conditions in Europe will be much more favourable for PAPER-P exploitation in this market segment.

Keywords: bioplastic,paper waste,printing industry,paper recycling,pyrolysis,anaerobic digestion,bioreactor