Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Antibody engineering by natural selection and by design (ENGRAB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 2478125.0
EU funding (EUR): 2478125.0
Participants: 1
Project status: SIGNED

Antibodies represent a powerful defense mechanism due to their capacity to link specific antigen recognition with effector functions and are currently developed as drugs for prophylaxis and therapy of infectious diseases. The generation of antibody diversity represents a remarkable example of protein engineering that is coupled to a stringent mechanism of clonal selection. In the ENGRAB project we propose first to develop an integrated bioinformatics platform to unravel the clonal dynamics of antibody responses and use it to formulate and test hypotheses on the factors that drive antibody selection in primary and recall responses, thus providing a rational basis for vaccination strategies. Second, we will establish the general relevance and impact of receptor-based antibodies, a new type of naturally engineered antibodies generated by templated DNA insertions into immunoglobulin genes. Third, we will use different bispecific antibody formats, including those produced by templated insertions, to engineer, in the same molecule, two binding sites for the HIV spike in order to increase neutralization potency and breadth. Fourth, we will engineer the Fc portion of antibodies to HSV, S. aureus and M. tuberculosis to increase their effector function through loss-of-binding to pathogen Fc receptors or gain-of-binding to human activatory Fc receptors. The program is strongly supported by preliminary findings and will deliver an innovative platform to interrogate natural antibody repertoires and new strategies to engineer antibodies to improve their therapeutic efficacy. The ENGRAB project deals with mechanisms of antibody diversification and engineering with implications for vaccination and immunotherapy. It is therefore submitted to LS6. Given its translational potential it also falls within the scope of LS7.

Keywords: antibody engineering,neutralizing antibodies,bispecific antibodies,memory b cells,plasma cells,somatic mutations,affinity maturation,vaccines,templated insertions
CROATIA: INNOVATIVE ENTERPRISE WEEK 2020 (HAMAG-BICRO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Access to risk finance
Theme: Debt facility
Action type: Coordination and support actions
Countries involved: Croatia
Call: 13. Innovative Enterprise Week 2020 (H2020-IBA-ARF-InnoWeek-2020, 2020)
Start date: 2020-01-15
End date: 2020-11-14
Duration (months): 10.0
Total project cost (EUR): 365000.0
EU funding (EUR): 350000.0
Participants: 1
Project status: CLOSED

Access to finance for innovative SMEs Small and medium-sized enterprises (SMEs) are the backbone of the European economy with strong contributions to employment, innovation, growth, and social cohesion. They therefore deserve special attention and true support to enable them to further contribute to a prosperous Europe. Sufficient access to external finance - with the main goals of filling the gaps in funding for early-stage, high-risk research and innovation by SMEs, as well as stimulating breakthrough innovation - for SMEs is crucial to obtain economic growth, job creation and competitiveness of enterprises. It is one of the central elements in the European economic policy debates. To improve access to finance for SMEs, the EU as well as most EU Member States support SMEs with a wide range of loan, guarantee and/or equity instruments to mitigate market failures in SMEs finance. In addition, in the past years the EU initiated both the Investment Plan – of which SME-financing is an important part – and the Capital Markets Union Action Plan aiming at establishing an integrated capital market in the EU to boost the creation of jobs and economic growth. Objective of the project is to organize a 2 full day international conference CROATIA: INNOVATIVE ENTERPRISE WEEK 2020 (year 2020), including a restricted VIP-dinner/reception in the evening prior to the conference (year 2020). Objective of the conference is to raise awareness of the potential for the financial instruments, facilities and accompanying measures launched, in particular, under Horizon 2020 to enhance access to finance for research and innovation. The conference will focus on financing and financial tools for developing innovative products and services in highly innovative Small and medium-sized enterprises. (SMEs) Horizontal topics: Artificial Intelligence (AI), ICT / Energy sector

Keywords: eu innovation enterprise accesstofinance ai energy ict
From hydrocarbons to original chiral building blocks: new solutions for sustainable & asymmetric CH functionalization of alkanes (AlCHIMIE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1499800.0
EU funding (EUR): 1499800.0
Participants: 1
Project status: SIGNED

Over the last decade, major environmental concerns, a growing worldwide population and an increasing energy demand, combined with the depletion of natural resources, have become crucial issues. Sustainable chemistry-ably to supply society with key chemical products in an eco-compatible manner-has therefore rapidly become an urgent challenge. The AlCHiMIE aims at providing new solutions towards this important defy by developing a set of complementary approaches to convert hydrocarbons, the simplest feedstock, into high value-added chiral alkanes-essential building blocks for medicinal chemistry. Two approaches are thus proposed. First, undirected, metal-free functionalization of hydrocarbons will be achieved by means of regio- and stereo-selective hypervalent bromine-enabled C-H functionalization. This unique reactivity will be attaint by discovering a largely uncharted, yet extremely appealing field of bromanes. The second approach concerns earth-abundant metal-catalyzed C(sp3)-H activation. To obviate the inherent difficulties of this field, namely the low reactivity of alkanes and arduous stereoinduction while using 3d metals, I will develop bifunctional ligands for Co- and Ni-catalyzed C-H activation. In addition to the role of metal coordination, these ligands featuring a second coordinating motif, will enhance the metallation event and will promote the substrate’s activation, thus unlocking the door towards previously inaccessible modes of reactivity. The combination of both strategies will allow unprecedented hydrocarbon valorization by means of undirected, hypervalent bromine-enabled first functionalization followed by exploiting the newly installed coordinating motif to promote directed, asymmetric Co- and Ni-catalyzed C-H activations. Finally, I will also endeavor in establishing new reactivities arising from the application of diversely substituted hypervalent bromines as coupling partners in enantioselective Co- and Ni-catalyzed C-H activations.

Keywords: c h activation,direct functionalization,bifunctional ligands,3d metals,bromonium,hypervalent,asymmetric catalysis
Structural safety improvement of offshore tall wind turbines under wind and wave loadings (OFFSHORE TALL TOWER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-14
End date: 2021-02-13
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Wind energy has rapidly developed as a clean and renewable energy source in recent years in order to meet the increasing demand for power. The European Union has already installed over 50GW of wind power generating capacity and has planned to increase the use of wind energy in order to reduce carbon dioxide emissions by 20% by the year 2020 (Tabassum et al., 2014). The use of wind turbines is nowadays the principal technology for generating electrical power from wind, and therefore wind energy converters need to be thoroughly investigated with respect to their capacity, effectiveness and integrity. It is widely known that wind energy potential (greater wind speeds) is greater in higher atmospheric levels, where wind flow is smooth enough as is far from the disturbed built environment. Therefore, higher towers are needed in engineering practice as the technology develops. The space used for offshore wind farms is also more flexible than that on land. For offshore wind turbines, their environmental loads are more complex than onshore ones including higher average wind velocity and wave loadings. Thus, this makes the development of a new tall offshore tower configuration imperative for the construction of offshore structures under wind and wave loadings.

Keywords: offshore wind turbine tower,wind and wave loading,fatigue performance,experimental study,scaled down model,wind tunnel test
Low-cost and high-performance pocket Automated Vehicle Monitoring system for Public Transport (CELSO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

AVM (Automated Vehicle Monitoring) systems are a key ITS technology for Public transport, guaranteeing real-time control of bus fleets on the network. They support ticketing and user information systems and report service performances. However, existing AVM present 3 key weaknesses that prevent them from being fully implemented and exclude smaller transport operators from equipping their fleets: a. complex technical features; b. significant resources needed for purchase and implementation; c. lack of an automatic data validation process. CELSO has been developed to address these 3 weaknesses. It is a low-cost, pocket AVM solution. It uses large diffusion technologies for provide all the functions of existing systems via a smartphone/tablet–based APP (CELSO MOB). Moreover, it enhances performance of conventional AVM, thanks to a specific module (CELSO Validator) which validate data collected by the system automatically. The target users of CELSO are not only Transport Operators (small and large), but also Public Transport Authorities s and other Authorities in charge of service contract monitoring/management. The simple and light architecture of the system can be easily customised to specific users needs, allowing CELSO to reach a large EU and international target market. CELSO is currently a prototype product, which has been tested and proved to be effective, yet it requires further engineering and commercialisation analysis before being placed on the market. For this reason, the Feasibility Analysis to be developed in this project aims to enhance CELSO specifications (determining any needed software and hardware improvements) and develop the product business model. Special attention will be paid to the needed adjustments at Company organisation level to manage CELSO commercialisation and post-sales activities efficiently.

Keywords: avm automated vehicle monitoring system,public transport,low cost,its intelligent transport,systems,service efficiency
Enable RPAS Insertion in Controlled Airspace (PJ13 - W2 ERICA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Spain,Ireland,Italy,Germany,Italy,Belgium,Croatia,Hungary,Lithuania,Romania,Slovakia,Sweden,Norway,Belgium,Poland,Poland,France,France,France,France,France,Czechia,Czechia,Czechia,United States,Netherlands,Denmark,United Kingdom
Call: PJ.13 W2 IFR RPAS (H2020-SESAR-2019-1, 2019)
Start date: 2019-12-01
End date: 2023-03-31
Duration (months): 40.0
Total project cost (EUR): 27119491.96
EU funding (EUR): 13150435.87
Participants: 52
Project status: SIGNED

Remotely Piloted Aircraft Systems (RPAS) have positively impacted civil and military applications. RPAS access to non-segregated airspace is essential to exploit their full capabilities, offering new services to the community and enabling market opportunities with huge economy benefits. To make insertion of RPAS into the ATM system a success, key challenges have to be addressed: to design a harmonised way to operate in nominal and emergency conditions; that RPAS do not adversely impact operations of existing airspace users; to ensure interoperability with current safety nets; to develop common standards and procedures. ERICA will assess operational and technical capabilities to allow RPAS to safely operate (in nominal and emergency conditions) in controlled airspace (class A to C) and will develop and validate solutions without negative impacts on air traffic. A Detect and Avoid system for the “collision avoidance” and “remain well clear” functions will be developed. A framework for inserting RPAS into the non-segregated airspace will be developed in two streams: “Accommodation”, with platforms, missions and applications to meet the initial demand, exploiting existing capabilities, and “Integration”, to reach the final objective. The benefits expected from the project are: developing recognised European RPAS operations in non-segregated airspace; enabling civil and military RPAS, fixed and rotary wing aircraft, to operate mixed with the manned traffic under a single European sky; increasing RPAS access to the airspace and equity with conventional traffic; contributions to regulatory and standardisation bodies; assuring interoperability with ATM system within and outside Europe; Safety, Human Performance and Cyber Security KPAs will also be investigated. The ERICA partnership, which consists of expert ANSPs, Industry and R&D stakeholders, brings the essential assets to deliver the RPAS integration with a common European view, the key for the success of the Project.

Keywords: rpas,unmanned aircraft,air traffic insertion,detect and avoid,air traffic management,accommodation,integration,controlled airspace,regulation,collision avoidance
Scale-Free Control for Complex Physical Network Systems (Scale-FreeBack)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France,France,France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2873601.0
EU funding (EUR): 2873601.0
Participants: 3
Project status: CLOSED

Technology achievements were typically built upon fundamental theoretical findings, but nowadays technology seems to be evolving faster than our ability to develop new concepts and theories. Intelligent traffic systems benefit from many technical innovations, for example. Mobile phones, radars, cameras and magnetometers can be used to measure traffic evolution and provide large sets of valuable data. Vehicles can communicate with the network infrastructure, as well as each other. However, these huge technological advances have not been used to the full so far. Traffic lights are far from functioning optimally and traffic management systems do not always prevent the occurrence of congestions. So what is missing? Such systems affect our daily life; why aren’t them on pace with technology advances? Possible because they have become far more complex than the analytical tools available for managing them. Systems have many components, communicate with each other, have self-decision-making mechanisms, share an enormous amount of information, and form networks. Research in control systems has challenged some of these features, but not in a very concerted way. There is a lack of “glue” relating the solutions to each other. In the Scale-FreeBack project, it is proposed to approach this problem with a new holistic vision. Scale-FreeBack will first investigate appropriate scale-free dynamic modeling approaches breaking down system’s complexity, and then develop control and observation algorithms which are specifically tailored for such models. Scale-FreeBack will also investigate new resilient issues in control which are urgently required because of the increasing connectivity between systems and the external world. Road traffic networks will be used in proof-of-concept studies based on field tests performed at our Grenoble Traffic Lab (GTL) and in a large-scale microscopic simulator.
Improving access to digital cultural heritage for multiple users and uses via a disruptive cloud based software as a service (COMWORK)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Italy
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The highest priority for around 17.000 European SMMs in the next few years is to implement a digital age shift in order to find a new and sustainable business model that works within the context of our changing society. Going digital for SMMs, with few paid staff and limited resources, is challenging. A recent survey highlights that most significant barriers to digital development in Museums are slow or limited IT systems and network (52%), lack of time (80%) and lack of resources (66%).CoMwork srl an innovative and social start-up, spin off of TAI: has been created to further proceed with the market readiness of CoMwork's solution, a game-changing platform for museum collection management that fosters a new business model for the sector. Being 64% lower cost than alternative solutions, Small and medium museums (SMM) will avoid upfront investments for licencing or high annual fees and costs for additional modules. Through the project we expect an increase of around 700.000 new digital content pages available on the web from SMMs by 2020, meaning an increased revenue of target museums of around 20%. In combination, expected revenues for CoMwork are estimated to be around 4,2M€ in 4 years from market launch.

Keywords: reflective societies,small medium museums,digital cultural heritage,cloud based,software as a service,new business models
Counting as a Human Being in the Era of Computational Law (CoHuBiCoL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium,Netherlands
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 2559916.25
EU funding (EUR): 1963445.0
Participants: 2
Project status: SIGNED

This project will investigate how the prominence of counting and computation transforms many of the assumptions, operations and outcomes of the law. It targets two types of computational law: artificial legal intelligence or data-driven law (based on machine learning), and cryptographic or code-driven law (based on blockchain technologies). Both disrupt, erode and challenge conventional legal scholarship and legal practice. The core thesis of the research is that the upcoming integration of computational law into mainstream legal practice, could transform the mode of existence of law and notably of the Rule of Law. Such a transformation will affect the nature of legal protection, potentially reducing the capability of individual human beings to invoke legal remedies, restricting or ruling out effective redress. To understand and address this transformation, modern positive law will be analysed as text-driven law, enabling a comparative analysis of text-driven, data-driven and code-driven normativity. The overarching goal is to develop a new hermeneutics for computational law, based on (1) research into the assumptions and (2) the implications of computational law, and on (3) the development of conceptual tools to rethink and reconstruct the Rule of Law in the era of computational law. The intermediate goals are an in-depth assessment of the nature of legal protection in text-driven law, and of the potential for legal protection in data-driven and code-driven law. The new hermeneutics will enable a new practice of interpretation on the cusp of law and computer science. The research methodology is based on legal theory and philosophy of law in close interaction with computer science, integrating key insights into the affordances of computational architectures into legal methodology, thus achieving a pivotal innovation of legal method.

Keywords: rule of law,algorithmic regulation,philosophy of technology