Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel activity-based proteome and lipidome profiling of Arabidopsis in response to a changing environment: An opportunity to identify new key players in plant lipid metabolism (LIPIDQUEST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2013-02-28
End date: 2017-12-26
Duration (months): 36.0
Total project cost (EUR): 257610.0
EU funding (EUR): 257610.0
Participants: 1
Project status: CLOSED

LIPIDQUEST is based on new cutting edge developments in the area of proteomics and mass spectrometry and focuses on identifying new key players in lipid biology in the model plant Arabidopsis thaliana. Short term output will advance our understanding of lipid biosynthesis and turnover and has the potential to contribute to medical applications; ultimately, such research will increase the world’s chances to become less dependent on fossil fuels and thus fight the threatening energy crisis as well as climate change. 3 different approaches have been chosen to deliver new gene candidates combining uniquely Dr. Kelly`s skills in the area of storage and membrane lipids in higher plants, Associate Prof Wenk’s multidisciplinary approaches using lipidomics as well as Prof Feussner’s proficiency in lipidomics and plant lipid biochemistry: 1- A novel screen based on protein-lipid interactions is targeted at capturing lipases and other lipid-binding proteins by a combination of proteomics and subsequent mass spectrometry. 2- Alternatively, a suppressor screen of a mutant impaired in ß-oxidation will identify key components between membrane lipid degradation and ß-oxidation. 3- In a forward genetic approach state-of the art lipidomics will be performed on a selected subset of Arabidopsis mutants and on the large genetic pool of intercrossed Arabidopsis accessions which will be exploited to reveal the genetic grounds for functional differences in the lipidome in response to a changing environment. This project will add to the European expertise within state-of the art lipidomics and applied plant biology and will establish the grounds for long lasting collaborations between the University of Göttingen and the National University of Singapore. In addition, it will allow Dr. Kelly to substantially deepen her technical skills necessary for a successful completion of this project and will provide her with the scientific grounds to continue with her very own line of research.

Keywords: bioenergy,climate change,increasing oil content,lipase inhibitor screen,orlistat,proteomics,lipidomics,qtl analyses,natural variation,membrane homeostasis,lipid transport,arabidopsis
Stable Unsaturated Silicon Clusters as Nucleation Sites in Solution and the Gas Phase (CASI-CVD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 174475.2
EU funding (EUR): 174475.2
Participants: 1
Project status: CLOSED

Amorphous silicon (a-Si) is an important industrial material. It is used widely in electronic devices such as thin-film transistors (TFTs). Solar energy generation also relies heavily on a-Si for mass produced photovoltaic cells. Amorphous silicon is prepared via chemical vapour deposition (CVD) from silanes (e.g. SiH4), in which small, unsaturated silicon clusters are short-lived gas-phase intermediates. Significantly, such clusters are incorporated into the bulk a-Si and are critical in determining fundamental properties of the material, such as optical and electronic band-gaps. Crucial details of structure and bonding in these clusters are elusive. We propose to build on the emerging chemistry of isolable, stable unsaturated silicon clusters. Using a novel systematic synthetic approach, we will prepare stable unsaturated silicon cluster compounds as models for the unsaturated clusters present in CVD processes. We will exploit the reactivity of these compounds to use them as solution-phase nucleation sites for cluster expansion. The electronic and photo-physical characteristics of these compounds will be investigated, shedding light on the analytically elusive clusters present in a-Si. We will use unsaturated silicon clusters as gas-phase nucleation sites for the CVD of a-Si (Cluster Assisted Silicon CVD - CASi-CVD). By depositing a-Si from gas phase mixtures of silanes and our novel clusters we will be able to control the concentration and properties of the residual unsaturated clusters in the a-Si produced. Improved control over these parameters is directly relevant to industry: it would allow improved materials for semi-conducting electronics and solar-energy generation. Such advances would increase the global competitiveness of the EU. The fellow will gain high quality training in main group chemistry and materials chemistry (deposition of a-Si) as well as complementary skills training that will equip the fellow for a top level independent research career.

Keywords: inorganic chemistry,organometallic chemistry,main group chemistry,cluster compounds,low valent,silicon,chemical vapour deposition,cvd
EFFECT OF SOIL ARCHITECTURE ON TRANSPORT AND RETENTION OF SILVER NANO-LITTER (SOILARCHNAG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-11-01
End date: 2014-10-31
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

A lack of understanding of the human and environmental health implications of nano-materials has deterred public and scientific support for nanotechnology evolution across industries. Nano-silver in particular has gained increasing popularity due to its biocidal properties in the garment industry to create odor-free clothing. An increase in “nano-litter” release to the environment is expected from erosion by product use and land application of nano-litter enriched wastewater sludge. This project will investigate the transport of nano-silver in soils through laboratory experiments using a novel 3-dimensional soil model technique that creates reproducible replicates of real soil pore networks, and simulations that combine non-equilibrium statistical physics of particle-solid interactions with information of Lattice-Boltzmann flow fields. The objectives are to: i) determine the effect that soil structure has on the transport of nanoparticles, ii) assess the capacity of soils under different land management practices (and therefore different soil architectures) to filter out suspended nano-litter from groundwater, and iii) develop a modeling tool to help industry forecast the propagation of nano-enabled products and their derivatives through soil environments from product use and disposal. The findings of this study are expected to directly impact environmental policy in the host country as well as worldwide.

Keywords: natural sciences,physical sciences,nanotechnology,environmental policy
Space Debris Evolution, Collision risk, and Mitigation (SPACEDEBECM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 185763.6
EU funding (EUR): 185763.6
Participants: 1
Project status: CLOSED

Space debris is internationally recognised as hazard to current and future space activities. This proposal will investigate the orbital dynamics of space debris through semi-analytical models of their motion under the effect of orbit perturbations. The long-term evolution will be investigated through formulations obtained by averaging techniques of the dynamics equations. This will allow a deeper insight into orbit debris evolution under the effect of natural orbit perturbations in the Earth environment. It will be possible to identify resonance conditions for quasi-equilibrium orbits for space debris objects. In the current state of the art particular focus is given to Geostationary Earth Orbits and Low Earth Orbits region, as space activities are mostly concentrated in these areas. In this research we aim at building a general catalogue of families of frozen orbits for debris fragment. The definition of these orbits will potentially suggest novel ways of active debris removal by identifying natural sinks orbit where debris can be naturally collected. Moreover, techniques previously developed for the deflection of Near Earth Objects will be extended to design optimal trajectories for interception and deflection or active removal of space debris. A formulation of the debris problem will be developed, which allows assessing the effectiveness of any proposed mitigation strategy. Methodologies for the design of optimal transfers to the interception of space debris will be studied. Once first guess solutions for the overall mission have been identified, a selected number of refined trajectories can be optimised, using a more accurate model of the system dynamics. In this context, this research aims to study and develop techniques for the solution of the optimal control problem associated to the design of low-thrust trajectories, in order to fully exploit the problem dynamics within the optimisation process, and to provide robustness in convergence.

Keywords: astrodynamics,gravitation,classical mechanics,mathematical physics,flight physics,aerospace engineering,applied mathematics,flight mechanics,space debris,orbit perturbation,system dynamics,mitigation
Discovery of Atherosclerosis Microbiome: Systems Biology of Cardiovascular Pathogenesis (CARDIOMICROBIOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-06-04
End date: 2014-06-03
Duration (months): 24.0
Total project cost (EUR): 226548.4
EU funding (EUR): 226548.4
Participants: 1
Project status: CLOSED

The target for this project is a novel approach addressing the infectious component of atherosclerosis, a disease which leads to myocardial infarction and stroke. Using immunology, cellular microbiology, genomics/metagenomics and fluorescence microscopy, our multidisciplinary team was the first to demonstrate vascular cell transmission of bacterial pathogens, the first to show association of dormant invasive bacteria with atheromatous tissue and, most importantly, the first to develop a technology to isolate and identify previously uncultivable bacterial pathogens from such tissues from patients. The objectives of this innovative proposal are to describe for the first time a critical for public health segment of the human microbiome, the atherosclerosis microbiome, to cultivate and identify its members and to determine the prevalence of these species in patients’ tissues. Further, we will examine the physiological capability of the pathogens to modulate 1) the lipid metabolism, 2) the pro-inflammatory response and 3) the viability of atheromatous tissue resident cell types, human phagocytic, endothelial and smooth muscle cells (SMCs). This will allow us to reveal the functional significance of the members of the atherosclerotic microbiome that may be critical for atherogenesis. This proposal builds on the excellence in the field of atherosclerosis research of the ICCC and of the Columbia University Medical Center in New York City. The deliverables of this project include much-awaited clarification of an entirely novel risk factor for atherogenesis that will benefit the majority of the EU population, at risk of number one cause of death. This focused project will define entirely novel targets for theragnostic clinical developments in the critical area of cardiovascular disease. Notably, bacterial infections can be a modifiable risk factor, making the accomplishment of this project a significant advancement, opening a new field in vascular medicine.

Keywords: health sciences: atherosclerosis,microbiome
The coordination of dendritic spine morphogenesis and function during synaptic plasticity and pathology (MORPHINGSYNAPSES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-12-01
End date: 2015-11-30
Duration (months): 36.0
Total project cost (EUR): 283568.1
EU funding (EUR): 283568.1
Participants: 1
Project status: CLOSED

Long-term synaptic plasticity is believed to underlie learning and memory and also the tuning of neural circuitry during development. Plasticity of excitatory synapses involves both changes in the function and morphology of dendritic spines, small actin-rich, dynamic protrusions that are the sites of excitatory neurotransmission. The coordination of the structure and function of dendritic spines is essential for proper cognitive function, however the molecular mechanisms that link these processes remain elusive. This project will investigate how the remodelling of excitatory synapses in the brain is controlled by members of the small GTPase family of molecular switches and their regulators, and how these signalling pathways are disrupted in mental disorders. Specifically, I will investigate the regulation of spine structure and function by Epac2, a newly characterised synaptic guanine-nucleotide exchange factor (GEF) that activates the small GTPase, Rap. Recently identified coding mutations in the EPAC2 gene detected in autistic subjects cause functional impairment of this protein, producing abnormal synaptic phenotypes. Therefore, elucidating the roles of Epac2 signalling in controlling synapse morphology and function will be essential to our understanding of the potential role of this pathway in this mental disorder. To accomplish this, I have developed an exciting multidisciplinary project focused on the role of Epac2 in spine morphology in vivo and how this impacts on synaptic connectivity and behaviour. I will use state-of-the-art in vivo techniques to examine spine morphology in EPAC2-/- knock-out mice and mice expressing autism-associated Epac2 mutants. I will then decipher the molecular mechanisms that link Epac2 function and shrinkage of dendritic spines to reduced synaptic function, and how this process is altered in the context of autism.

Keywords: neuroscience,gtpases,ampareceptors,synapse,ltd,plasticity,endocytosis,dendritic spine,epac2,autism
Biogeochemistry of erosive material deposition in streams: Impact of particulate deposition upon biofilm carbon cycling. (BIO-ERODS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 187888.2
EU funding (EUR): 187888.2
Participants: 1
Project status: CLOSED

Inland waterways are an important component of the global carbon cycle, receiving an annual carbon input of ~ 4.8 Pg of carbon per year. Of this approximately 0.6 Pg is buried, entering the lithosphere, whilst 3.3 Pg is recycled through aquatic food webs. These numbers highlight the global importance of streams, rivers lakes and other inland waters but provide little detail regarding the dynamics of organic matter burial and remineralisation. A poorly defined aspect is the relationship between organic matter burial and remineralisation of organo-mineral complexes. Organo-mineral particles form by adsorption of dissolved organic matter to freshly-eroded mineral surfaces, and are thought to greatly control the fluxes of particulate organic carbon at the watershed scale. The unique physico-chemical properties of these particles may enhance their deposition onto and subsequent burial into the sediments of inland waters. However, the metabolic fate of these particles at the water-streambed interface remains poorly studied. Particle deposition at the streambed is enhanced by benthic microbial biofilms. As such, understanding the potential role of organo-mineral complexes in the preservation and burial of organic matter, requires investigation of the interactions with biofilms. Bio-ERODS aims to experimentally investigate biophysical mechanisms driving biofilm-particle interactions and mechanisms that potentially alter the organo-mineral complexation and thus contributing to stream biogeochemistry. Bio-ERODS will thus elucidate, at the fine scale, fundamental mechanisms of the controls on carbon fluxes in streams and rivers.

Keywords: natural sciences,ecology,stream,biofilm,carbon cycling,fresh water ecosystems,biogeochemistry
Nanostructured & Biomimetic Ceramic-Polymer Composites for Bone Tissue Regeneration (NBC-REGEN4)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

The interdisciplinary proposal NBC-ReGen4 is based on the existing expertise in materials science of the incoming European Fellow (Dr. Piergiorgio Gentile) in combination with the host laboratories knowledge of biocompatibility assessment and medical device development (University of Sheffield-Scientist in charge: Prof. P.V. Hatton). NBC-ReGen4 is a timely project with respect to the scientific and technological advance on the state-of-the-art and with clear translational relevance to industry and ultimately patients. It aims to produce, characterise and evaluate a series of nanostructured composites with significantly improved properties compared to the existing state-of-the-art, specifically including suitable membranes for guided bone regeneration. Conceptually, the adaptation of nanostructured composite membranes for the development of functional devices in different applications represents a major step forward in the increasingly competitive field of tissue engineering and regenerative medicine. It is also an ideal time to train a talented materials scientist in new methods related to biological evaluation of a biomaterial, as well as transferable skills that will significantly boost his career prospects and opportunities to contribute to society. In detail, in NBC-ReGen4 the innovative composite membranes will be based on commercially available or in-house fabricated calcium phosphate particles incorporated into a resorbable medical polymer matrix (polyglycolic acid or poly(lactide co-glycolide)) further processed by electrospinning. The obtained composite membrane will consist in bilayered structures that can be modified and characterised for specific applications where bone tissue regeneration is required on only one side. Surface functionalization of the different layers to enhance specific properties (such as biomimetic and anti-inflammatory properties) by low-risk and environmentally-friendly techniques, will be also implemented.

Keywords: biomimetic,guided bone regeneration,layer-by-layer,plasma treatment,surface modification,tissue engineering
Mediating Semi-Authoritarianism: The Power of the Internet in Russia (MESAPORUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

How – and with what consequences – has the emergence of new modes of internet-mediated (i.e. networked, interactive) communication changed our societies in recent years? This is a question that is central to a growing body of communications literature that is often referred to as “mediatization” or “mediation” research. However, while being based on a wide array of disparate theoretical assumptions and methodical approaches, virtually all the current studies on “mediatization” have one feature in common: Their empirical focus lies on western, developed, democratic societies. In the face of this “western bias” of extant research on mediatization, the primary goal of this project is: to take under close scrutiny the mediatization of the political sphere in contemporary semi-authoritarian Russia. To accomplish this goal, this project will seek, for instance, to fathom how common Russians have integrated blogs into their daily news diets and how oppositional politicians make use of blogs as new tools of political communication in the elections in 2011/12. Investigating the Russian case appears intriguing and relevant not only because the country remains a major nuclear and energy power, but also because the Russian internet – in sharp contrast to its Chinese counterpart – is currently not at all being technically filtered. Moreover, at the level of interpretation, a comparative perspective with other (semi-)authoritarian regimes (primarily in Asia and the Arab world) is aspired. Thus, the project will also add valuable and nuanced contributions to the currently ongoing, intense academic debate on the broader question whether the internet in the context of non-democratic regimes is to be seen rather as a “technology of liberation” or as a "technology of control".

Keywords: social sciences,communication sciences,political science,social psychology,new media,democracy,democratization,internet-mediated communication,blogs,russia,web 2.0,political communication