Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Clinical studies on the precursor condition monoclonal gammopathy of undetermined significance - with focus on complications and prognosis (MGUS PROGNOSIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Iceland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Multiple myeloma (MM) is an incurable hematological malignancy characterized by an M-protein shown in electrophoresis of the blood. Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant asymptomatic condition in which an individual has an M-protein, but no underlying malignancy. MGUS is present in 5-10% of the elderly and precedes all cases of MM, however, not all MGUS patients will progress to MM. An accurate method to predict which patients will progress to MM and related diseases is lacking. Thrombotic issues have recently become a major clinical problem in MM. In addition, we have found that individuals with MGUS have an increased risk of both venous and arterial thrombosis. The underlying mechanisms for the thrombosis risk in MM and MGUS patients remain unknown. In this research project, we will study the well-defined, population-based AGES-RS, a longitudinal cohort study of 5,764 men and women in Iceland who have been screened with extensive clinical, laboratory and radiological examinations with focus on cardiovascular risk profile and diseases, bone disease, as well as all clinical events during follow-up. We will screen all individuals in the AGES-RS study for M-protein. The overall aims of the study proposal are to analyse morbidity and mortality among individuals with and without MGUS. We will then compare specific outcomes in individuals with M-protein (MGUS patients) versus those without. We aim to determine; what is the survival pattern for MGUS patients, what risk factors for malignant transformation (to MM or other malignancies) can be determined, and what risk factors for cardiovascular and bone disease do MGUS patients carry? By improving the prognostic models for MGUS we hope to be able to define high and low risk patients. Our results will hopefully shed light into several important aspects on MGUS and MM with special focus in the pathogenesis of thrombotic disease in MGUS and MM.
A Single Dose, Cytomegalovirus-based Vaccine to Induce Heterosubtypic Protective Immunity to Influenza A Virus (MAJARVISCIG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-07-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

There are 16 known avian IA virus serotypes, which are further subdivided phylogenetically into group 1 and group 2 viruses. IA 'pandemics' with the possibility for high mortality result from 'antigenic shift' following introduction of a virus with a new hemaglutinnin (HA) serotype into an immunologically naïve population. In contrast, IA 'epidemics' are a consequence of 'antigenic drift' caused by mutation of the HA serotype already circulating within the human population. Seasonal flu vaccines induce antibodies primarily against the globular highly variable head region of HA, and target only a single serotype (homosubtypic immunity). There are currently no commercially available vaccines that are able to induce immunity against multiple IA subtypes and thereby provide heterosubtypic immunity for a pandemic IA vaccine. This CIG project will be run in parallel of a larger collaborative study that is under review at the BBSRC focused on antibody (Ab)-mediated protection. The primary aim of this CIG proposal is to investigate the role of T cell responses (and particularly ‘effector’ T cell memory TEM responses that have immediate effector function and are enriched in lung tissue) in providing protection against pandemic flu. To enable the role of TEM in IA protective immunity to be assessed we will compare the protective efficacy of T cell immune responses induced against IA nucleoprotein (NP) by using 2 distinct vaccine vector platforms that differ in their induction of TEM responses. This is an area of flu vaccine development that has been largely overlooked. By running alongside the larger BBSRC study, this CIG project will take advantage of the infrastructure provided by the BBSRC proposal. The strategic goal of all these studies is development of an effective, safe, inexpensive, single dose universal vaccine against all serotypes of IA

Keywords: lif cytomegalovirus-based vaccines,influenza a,infactious disease,antibodies,immunology,virology,herpesviruses
European human Pluripotent Stem Cell Registry (EU-HPSCREG)

Framework: FP7 — Cooperation
Programme: Health
Destination: Health
Action type: Coordination and support actions
Countries involved: Germany,United Kingdom,Spain,United Kingdom
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2013-01-01
End date: 2015-12-31
Duration (months): 36.0
Total project cost (EUR): 549112.66
EU funding (EUR): 500000.0
Participants: 4
Project status: CLOSED

Human embryonic stem cell (hESC) research holds promise for regenerative therapies, offers a tool for drug discovery and toxicity tests, for studying human development, disease physiology and gene control. hESC lines are derived in an increasing number of laboratories accompanied by a widening scope of usage and application. This trend has not diminished since human induced pluripotent stem cells (hiPSC) became available as research and use of hESC and hiPSC rapidly co-develop. The advancing scope of the field, the increasing count of researchers, laboratories and institutions working with pluripotent stem cells (hPSC) and the ever growing number of hESC and hiPSC lines poses novel challenges, while further justifying the recognized need for a registry of hESC. This need has been addressed by establishing the European hESC registry (EU-hESCreg). The proposed project aims at sustaining and improving operability of EU-hESCreg, and to expand its content and usability in order to respond to the existing and anticipated challenges in the field. The European human pluripotent stem cell registry (EU-hPSCreg) will adapt its registration content and requirements to accommodate hESC and hiPSC. The inclusion of these most relevant pluripotent stem cells (hPSC) will broaden comparability and standardization of cell lines, advance knowledge dissemination and hence reduce the need for generating new hESC lines. The objective of the EU-hPSCreg is to promote access to hPSC lines and to provide transparency about their characteristics, to contribute to the harmonization of hPSC usage and develop it into an international hub. The project will (i) implement transparent criteria for registration, qualification and validation of hPSC, (ii) establish efficient means and tools for internal and external communication and dissemination of information , (iii) provide a reliable technical and regulatory basis for operation and (iv) establish efficient and strategic management.

Keywords: human embryonic stem cell pluripotent stem cellstem cell registry cell database
Systemic Risks and Macroprudential Regulation in Banking (MACROBANK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The current financial crisis raises fundamental questions concerning macroeconomics, banking stability, and economic policy. As standard macroeconomic models provide insufficient guidance on how to respond to the crisis, policy makers in Europe and elsewhere have repeatedly intervened with a combination of largely untested monetary and fiscal policy measures that comprise liquidity provision, quantitative easing, nationalisation, as well as other subsidies. While the microeconomics of banking is well understood, standard macroeconomics has failed to allow adequately for a financial sector. Systemic risks in the banking sector cannot be analysed in a dynamic framework. MACROBANK closes this gap by developing a novel dynamic macroeconomic model with a micro-founded banking sector. It aims at developing a theoretical foundation and a tool box for policy makers to analyse and assess the effectiveness of possible crisis intervention strategies to improve the overall understanding of crisis intervention and their effects on the economy. Extending Gersbach and Wenzelburger (2011), MACROBANK’s novel model allows to investigate the effectiveness of new crises intervention measures dynamically and to simulate policy strategies. It focuses on debt reduction, inflation control, and on how central bank activities can be restored to pre-crisis levels. Welfare distributional aspects of interventions are also considered. The novelty and expected impact of the proposed research will increase the EU’s excellence, and the applicants teaching activities will train young researchers exposing them to cutting-edge research in economics. Thus, the proposed project leads to knowledge transfer within and into the ERA, integration of a researcher, and introduction of a promising new research approach in Europe,

Keywords: e101 macroeconomics,e104 financial markets,banking crises,systemic risks,macro-prudential regulation
Mathematical Theory of Kinetic Equations and Applications to Coagulation and Fragmentation processes (KINETICCF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2018-02-27
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The work we propose focuses on the rigorous mathematical development of kinetic theory and the applications of its techniques to the study of models of population dynamics and cell fragmentation and growth in biology, to the dynamics of coagulation and fragmentation processes in physics, and to more recently developed models in the field of collective behavior. The aim is then twofold: to advance the understanding of basic equations in kinetic theory, such as the Boltzmann equation, and to employ known or newly developed techniques in this field to the rigorous treatment of models in the above mentioned areas, such as the Becker-Döring equation for nucleation, the growth-fragmentation model for cell populations, or individual-based models for collective behavior. The proposed work on the Boltzmann equation is a continuation of previous works of the applicant in collaboration with M. Bisi, B. Lods and C. Mouhot, mainly based on perturbation and entropy techniques in the study of asymptotic behavior of the elastic or inelastic Boltzmann equation.The work on applications builds on recent advances showing the successful applicability of techniques form kinetic theory in some models involving coagulation and fragmentation. In particular, we expect to obtain improved results on the asymptotic behavior of the growth-fragmentation equation, including the development and analysis of computer code to calculate the asymptotic profile; to apply entropy techniques to the full coagulation-fragmentation equation in order to study its speed of convergence to equilibrium; and to be able to apply perturbation techniques in the study of the scaling hypothesis for coagulation.

Keywords: m112 partial differential equations,m113 mathematical physics,m119 application of mathematics in sciences,l303 cell cycle and division,p117 statistical physics (gases),p218 phase transitions - phase
European Agencies and Epistemic Communities: Engines of European Integration in Internal Security? (EPISC-EU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2018-01-13
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

This project examines an important, but under-researched topic, namely the role of the growing number of European agencies dealing with internal security matters in European integration. More precisely, it investigates whether European agencies are 'engines' of European integration in internal security and, if yes, how and to which extent they fulfil that role. Pollack (2003) has emphasised that the European Commission, the European Parliament and the European Court of Justice have all played an important, albeit varied, role as engines of European integration alongside the governments of the Member States. It is true that the powers of agencies are more limited than those of these three institutions. They do not propose, adopt or annul legislation, but are specialised and 'depoliticised' administrative structures that perform the generally technical tasks that have been delegated to them (Majone 2006). However, they should not be readily dismissed as possible engines of European integration. Indeed, agencies have knowledge and knowledge is a form of power. It is therefore important to examine the extent to, if any, and the ways in which the growing number of European internal security agencies have influenced policy-making and European integration in internal security matters. In order to answer these questions, the project develops an analytical framework drawing upon the literature on 'epistemic communities', which are particular networks of knowledge-based experts. The project examines whether each of the nine European internal security agencies belongs to an epistemic community and, if yes, the extent to which this epistemic community has sought and managed to influence policy-making - thereby enabling the agency to act as an engine of European integration through its membership of the epistemic community. It is expected that the project will generate highly original and relevant findings, which will have a major impact on academic and policy debates.

Keywords: european union,european agencies,internal security,epistemic communities,european integration
Identification of novel regulators of growth and wood formation by studying natural variation in Arabidopsis and Betula pendula, a novel model tree (BETWOOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

My research aims to understand molecular mechanisms controlling growth and wood formation in plants. I will identify novel genes functioning in the regulation of cambial meristem activity by exploring its natural variation. I will use two complementary model species: herbaceous Arabidopsis and forest tree silver birch (Betula pendula). In Arabidopsis, I will identify genetic quantitative trait loci (QTL) associated with wood formation through a genome-wide association (GWA) study of sequenced accessions (ecotypes). I will further functionally study the role of causative genes in secondary development. I will also introduce a novel, second generation model species, B. pendula, into tree genetics. This tree is monoecious (both female and male flowers at the same tree), and tolerates inbreeding well. Even six months old trees can be induced to flower under greenhouse conditions, making advanced crossing schemes possible. Its small genome is currently being sequenced. Betula will bring the power of inbreeding and short generation times into tree genetics. A great resource for my Betula research is a collection of tree morphology and wood formation mutants established by my collaborator, Finnish Forest Research Institute. These mutants include trees with atypical tension wood formation, cambial activity, stem branching, branch morphology and secondary metabolite content. I will identify the causative mutations behind these phenotypes, and functionally study their role in tree development. For my future research, I will further explore natural variation in tree morphological and wood formation related traits. I will establish a collection of inbred tree lines, a QTL mapping population, a common garden of diverse birch ecotypes and a hybrid collection of interspecies crosses between different species of Betula genus. With Betula as a model tree, my project represents a novel approach of tree genetics, which has potential for ground-breaking insights into wood development.

Keywords: plant biology,plant development,tree research,betula,arabidopsis,secondary development,cambium,cambial development,wood formation,natural variation,xylem development,tree breeding
Multisensory processing in cortical networks underlying the formation of supramodal percepts (BRAINSENSE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-11-01
End date: 2016-10-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The neocortex underlies higher cognitive functions in mammals and humans. Its computational function is essential for categorizing external objects into supramodal percepts. This natural categorization depends on multisensory integration to become largely independent of the modality through which relevant input is acquired. In contrast, this remarkable cognitive ability is poorly emulated by artificial systems. The anatomical cortical architecture shows extensive connectivity across its different sensory areas, departing from the classically assumed hierarchical processing scheme. Recent studies demonstrated that primary sensory cortical areas coding for distinct modalities are already interconnected, but the computational role of these heteromodal connections is unknown. My goal is to test whether heteromodal interactions in primary sensory cortical areas transmit inferences about the identity of behaviorally relevant objects perceived across multiple sensory channels. The working hypothesis is that these interactions modify the primary representation of unimodal sensory stimuli, resulting in supramodal perceptual invariance, even in ambiguous unimodal contexts. This study will be carried out in awake behaving rodents trained to discriminate between two multimodal objects, which require the two sensory modalities to be fully distinguished. State-of-the art techniques (two-photon calcium imaging and multisite electrode arrays) to record from large scale neural assemblies, will be combined with modern analysis of neural population dynamics and network simulations. Underlying mechanisms will be explored by optogenetic targeting of specific neuronal populations. My long-term aim is to quantitatively explain encoding and classification of multisensory cues across primary sensory cortical areas. I hope to derive novel generic computational principles by which brain circuits build invariant representations of the environment from ever-changing multisensory input streams.

Keywords: l510 neuroimaging and computational neuroscience
Bottom-up Nanowires as Scanning Multifunctional Sensors (NWSCAN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Switzerland
Call:  (ERC-2013-StG, 2013)
Start date: 2013-11-01
End date: 2018-10-31
Duration (months): 60.0
Total project cost (EUR): 1480680.0
EU funding (EUR): 1480680.0
Participants: 1
Project status: CLOSED

Advances in growth and fabrication of semiconductor nanostructures have led to both the production of exquisitely sensitive force transducers and the development of solid-state quantum devices. Force transducers, typically monolithic Si cantilevers, are central to techniques such as AFM, and MFM. On the other hand, quantum devices including quantum wells, quantum dots (QDs), and single electron transistors are essential to technologies like lasers, optical detectors, and in experiments on quantum information. These two types of devices have – until now – occupied distinct material systems and have, for the most part, not been combined. New developments in the growth of inorganic nanowires (NWs), however, are set to change the status quo. Researchers can now grow nanoscale structures from the bottom-up with unprecedented mechanical properties. Unlike traditional top-down cantilevers, which are etched or milled out of a larger block of material, bottom-up structures are assembled unit-by-unit to be almost defect-free on the atomic-scale. This near perfection gives NWs a much smaller mechanical dissipation than their top-down counterparts, while their higher resonance frequencies allow them to couple less strongly to common sources of noise. Meanwhile, layer-by-layer growth of NWs is rapidly developing such that both axial and radial heterostructures have now been realized. Such fine control allows for band-structure engineering and the production of devices including FETs, single photon sources, and QDs. NWs are also attractive hosts for optical emitters as their geometry favors the efficient extraction of photons. These properties and the fact that a NW can be integrated as the tip of an SPM make NWs extremely promising devices. We propose to develop the use of NWs as scanning multifunctional sensors. We intend to 1) use NW cantilevers as force transducers in high-resolution scanning force microscopy, and 2) use NW quantum devices as scanning sensors.