Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Selective Inhibition of Bacterial Intramolecular Trans-Sialidases via a Multidisciplinary Computational/Experimental Approach (SELECT-IT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Netherlands,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 3
Project status: SIGNED

SELECT-IT aims to develop small molecules that specifically target bacterial intramolecular trans(IT)-sialidases. IT-sialidases from Ruminococcus species have been related to progression of inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Following elucidation of the yet unknown mechanisms of action of IT-sialidases, I will rationally design candidate inhibitors, synthesise and characterise them, and assess their binding modes, inhibition efficacy and target selectivity. Inspired by strategies previously successful for antiviral drugs like Tamiflu, SELECT-IT will modify existing molecules such as Siastatin B, DANA, and 2,7-anhydro-Neu5Ac, as starting points to develop candidates that selectively inhibits bacterial sialidases while sparing human ones. The inhibitors will undergo systematic refinement through computer simulation (molecular dynamics, QM/MM and metadynamics) and experimental techniques (biochemical assays and NMR spectroscopy) to ensure high specificity. SELECT-IT aims to develop targeted inhibitors for managing bacterial infections linked to IBD and CRC, contributing directly to the creation of new therapeutic options.

Keywords: drug design,enzymatic reactions mechanism,cazymes,neuraminidases
Building charge-MOSAIC nanofiltration membranes for removing micro-pollutants from surface and drinking water (MOSAIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Our surface and drinking water sources are increasingly threatened by the presence of organic micropollutants (OMPs). OMPs are small molecules (100-1000 Da) that originate from industrial, agricultural and pharmaceutical residues, and can cause long-term harm to humans and ecosystems. While OMPs can be removed from water with existing membrane technologies (e.g., reverse osmosis), these methods have significant limitations: they are energy-intensive and lead to problematic brine waste streams, due to their low water and salt permeability. In this project I aim to solve these limitations by building charge-mosaic membranes; membranes with small (nm2) oppositely charged patches that allow coupled passage of negative and positive ions. This design, aimed at reducing salt retention, was conceived over 90 years ago, but was never realized in a scalable manner due to its challenging design. Here, I propose a simple and fully scalable approach to achieve such membranes, using polyelectrolyte multilayers (PEMs) of oppositely charged polymers. I will build these charge-mosaic membranes using ultrathin, ultradense layers in an asymmetric PEM approach to achieve a very high (> 99%) retention of OMPs and a high water permeability. Combined with state-of-the-art modelling, this project will also provide new fundamental insights into membrane mass transport. Moreover, the project will directly lead to membranes with unique separation properties, allowing the design of completely new processes to effectively remove OMPs from waste water and drinking water. ter.

Keywords: polyelectrolyte multilayers,nanofiltration,contaminants of emerging concern,membrane surface science
RObust and Sustainable Additive Manufacturing of Amorphous Metallic Alloys (ROSAMA2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2025-06-30
Duration (months): 32.0
Total project cost (EUR): 218160.27
EU funding (EUR): 218160.27
Participants: 2
Project status: CLOSED

Bulk metallic glasses (BMGs) are promising materials to support the goal to make EU climate-neutral by 2050, and promote the growth of many industrial sectors such as biomedical. Thanks to their amorphous nature, BMGs offer an outstanding combination of high strength, corrosion/wear resistance and biocompability. Recently, Additive Manufacturing (AM) has been proposed as a solution to tackle the size limitation of the conventional casting production of BMGs. Still, many challenges remain to develop defect-free parts with mechanical performances comparable to their as-cast counterparts. In addition, to date, no post-processes can be applied to close porosity and improve quality without altering the amorphous state of the material. The project ROSAMA2 hosted by SIMaP in Grenoble aims to develop a RObust and Sustainable Additive Manufacturing of Amorphous Metallic Alloys by laser powder bed fusion. In situ X-ray microtomography will enable the 3D reconstruction of the deposited material layer-by-layer using a unique miniature system designed for usage at synchrotrons. The high brilliance of the radiation will reveal the quality of the powder bed, the morphology of the deposited material, the presence of defects in its volume and their evolution upon processing. Doing so, strategies to eliminate porosity in situ will be proposed. The printed BMGs will be evaluated to determine the role of defects, structural and chemical heterogeneities on the mechanical performances, by means of X-ray nanotomography, advanced thermal analyses, high resolution microscopy, nano-indentation and compression testing. In a final effort, strategies to enhance powder recyclability and limit pick-up of oxygen, harmful to the glass forming ability, will be developed, and the role of process atmosphere composition will be considered. Besides strengthening EU’s position on the AM market, ROSAMA2 will develop and consolidate Dr. Pauzon’s profile and secure future position in academia and industry.

Keywords: bulk metallic glasses amorphous additive manufacturing powder bed fusion robust sustainable in situ x ray tomography synchrotron defects oxygen impurity mechanical performance recyclability
INCOming MARSEILLE22 (INCOming MARSEILLE22)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Other ERA
Destination: Other ERA
Action type: Coordination and support actions
Countries involved: France
Call: Presidency event - Conference on international cooperation in research and innovation (HORIZON-WIDERA-2022-CONF-RI-IBA, 2022)
Start date: 2022-01-10
End date: 2022-07-09
Duration (months): 6.0
Total project cost (EUR): 399026.5
EU funding (EUR): 399026.5
Participants: 1
Project status: CLOSED

The aim of this project is to organise the Marseille Conference for International Cooperation (#INCO) under the upcoming French Presidency of the Council of the European Union during the first semester of 2022. This two-day Marseille Ministerial Conference being held on the 8th and 9th of March 2022, is an ambitious initiative to promote a Global Approach for Research and Innovation. The event aims at fostering exchanges and good practices setting off a new cooperation framework with partners based on the European Union’s values and objectives. This one of a kind initiative will encourage Europe’s Global Approach towards Research and Innovation. This CSA, will be managed by IRD (French National Research Institute for Sustainable Development) and will contribute to the success of the Marseille Conference which shall involve delegates, both European and International, along with selected external experts. As monobeneficiary of the grant, IRD will liaise with the MESRI (The French Ministry of Higher Education, Research and Education) and the MEAE (The French Ministry of Europe and Foreign Affairs) for the overall organisation of the Conference, . These two days shall be hosted across two different venues – The famous Palais du Pharo Conference centre and the MuCEM museum premises (Musée des Civilisations, de l’Europe et de la Méditerranée) in Marseille, south of France.

Keywords: french presidency of the council of the european union,global approach to research and innovation,international cooperation
Synergistic Advanced Carbon Capture Technologies for ConvERsion of Industrially Emitted CO2 to sustainable Production of biofuels and chEmicals (STEROPE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Greece,Spain,Belgium,Italy,Cyprus,Netherlands,Serbia,United Kingdom
Call: CCU for the production of fuels (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 8004112.94
EU funding (EUR): 6997520.0
Participants: 16
Project status: SIGNED

STEROPE integrates advanced Carbon Capture and Utilisation (CCU) technologies with innovative conversion processes to establish a circular economy model. By leveraging cutting-edge membrane and catalytic systems, it enhances the efficiency and scalability of CO2 capture and conversion into renewable e-fuels under real-world conditions. The project targets significant GHG emissions reduction and fossil energy displacement, aligning with the EU’s climate neutrality goals through cost-effective CO2 valorisation, green hydrogen integration, and energy optimisation. STEROPE demonstrates industrial symbiosis by deploying its prototype system within a refinery, enabling resource sharing and reuse. The project advances CCU technologies to deliver a first-of-a-kind TRL 7 system capable of producing e-methanol, e-DME, and sustainable aviation fuels (e-jet), offering viable decarbonisation solutions for hard-to-abate industries. The initiative develops and integrates three CCU units, which will be installed and tested at the Eleusis refinery (Greece) as part of a demonstration plant. The DEMO including the three prototypes will be integrated into the regular operation activities of the refineryA digital twin approach will enhance operational efficiency and optimise renewable e-fuel production. To ensure market readiness, STEROPE includes end-use testing of e-methanol and e-jet for compliance with shipping and aviation sector requirements, guaranteeing performance, safety, and regulatory approval. A comprehensive LCA and TEA will evaluate environmental and economic feasibility, while stakeholder engagement will drive market adoption and policy alignment. By fostering industrial symbiosis and innovative business models, STEROPE accelerates the transition towards a circular, low-carbon economy.

Keywords: co2 utilisation,efuels,ejet,emethanol,edme,industrial symbiosis,demo plan,circular economy,industrial symbiosis
Navigation for Visually Impaired Persons Regardless of Physical Location and Urban Interference Challenges (VIPER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2416684.0
EU funding (EUR): 2416684.0
Participants: 1
Project status: CLOSED

This application is centred on visually impaired persons (VIP) and the challenges they face during navigation. Today VIP navigation is still dominated by a white cane and, for those that can access them, a guide dog. Commercial providers have developed a range technical solutions to guide VIPs. However, none of the solutions can match the efficacy, intuitive nature and practicality of a guide dog and cane. MakeSense Technology is pioneering the world’s first ultra-precise mobility system for blind and visually impaired people. Our handheld device, the Vector, enables spontaneous and independent navigation through unfamiliar environments by delivering intuitive kinesthetic guidance with centimetre-level accuracy. The Vector is driven by an advanced pedestrian positioning system, which combines RTK-GNSS and iPhone-based Visual-Inertial Odometry. Developed from a research breakthrough at Imperial College London, the system has reached TRL 6, with proven feasibility in outdoor environments and commitments from major distributors across the UK and EU. EIC support is critical to bridge the gap between MakeSense’s validated prototype and full commercial deployment across Europe. The project requires substantial investment to complete large-scale field validation, secure certification, and harden our localisation engine. Given the lack of prior successes in the blind navigation market, our activities are too capital-intensive and high-risk for private investors alone. As a deep-tech assistive innovation with major societal impact but a niche early market, it perfectly fits the EIC’s mission to de-risk breakthrough technologies that deliver both economic value and social inclusion for Europe’s citizens.

Keywords: visually impaired persons,navigation,positioning
Shaping Hellenic National Identity between 18th and 19th centuries: how European intellectuals steered Greek and European History (HeNaId)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Switzerland,Greece
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 412700.52
EU funding (EUR): 412700.52
Participants: 3
Project status: SIGNED

What role did textual exchanges (epistles, journal essays and newspaper articles) between Italian philhellenes and (Italian)-Greek intellectuals refugeed in Italy (due to long-term cultural/political bonds) and Switzerland (as host country for many Greek exiles) play in setting ground for the 1821 Greek Revolution? How did the reflections of these intellectuals on the idea of Greekness, on contemporary historical events and on the illuministic ideas contributed to the process of national identity negotiation underlying the Revolution? Answering these questions is crucial to fully understand the role of the Greek Revolution in shaping modern Europe. HeNaId will offer the first in-depth study of these textual exchanges, focusing on texts by major (Italian-)Greek intellectuals with a focus on the poet Ugo Foscolo as a leading figure among those. While the ideological roots of Greek Revolution are generally studied from historical-philosophical or iconographic perspectives, HeNaId will fill a gap in scholarship by adopting an interdisciplinary approach combining archival and bibliographical research with a philological-literary investigation to 1) map out the political and cultural networks of (Italian)-Greek intellectuals between 18C and 19C across Greece, Italy and Switzerland; 2) study the texts exchanged within these networks to understand their degree of influence; 3) highlight the so-far neglected role played by Foscolo in promoting and orientating these cultural networks. Employed methodologies will be greatly improved through an outgoing phase at the leading Foscolo study group of the University of Fribourg, a secondment at the Laboratory in Italian History and Historiography at the Kapodistrian University of Athens and thanks to the main host University of Bergamo’s commitment to textual criticism. Working at these institutions will deepen my skills in Italian/Neo-Hellenic studies, thus accelerating my career goal of obtaining a tenure at an EU University.

Keywords: cultural networks textual exchanges ugo foscolo philhellenism greek revolution italian literature neo hellenic literature
Hair In the Middle- A Unique Tool For Planar Polarity Disruption In Arabidopsis Root Cells (HIM)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,Austria,Germany
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 191918.16
EU funding (EUR): 191918.16
Participants: 3
Project status: SIGNED

In the plant root or stem, cells orient themselves along the basal and apical axis. This polarity determines incorporation of important proteins such as plant hormone transporters or structures such as root hairs, which always emerge at the basal pole of the root hair cell. What mechanism governs this polarity is unknown. The source of polarity signal, referred to as the Unknown Polarity Cue (UPC), has stumped the scientific community for decades, largely attributed to the failure to reliably and significantly disrupt the planar polarity of the plants. The host laboratory pioneered the method to interfere with the UPC by ectopically expressing polarity cues from the root columella - NGR proteins. Resulting plant lines exhibit a previously unachievable root hair displacement to the middle of the trichoblast- HIM phenotype and other phenotypes consistent with full loss of the planar polarity. I will use targeted NGR expression and subcellular targeting as a tool to understand how plant planar polarity is established. By investigating and functionally characterising the NGR family proteins and how they interrupt the UPC, I will unravel the origin and character of the UPC, as well as mechanisms driving its manifestation. Successful delivery of the project will equip the scientific community with fundamental knowledge on plant planar polarity establishment and generate innovative tools for directional membrane targeting, complemented by optogenetic control over membrane domain assembly. Furthermore, experience, skills and networking opportunities gained through the implementation of the MSCA Action will elevate my postdoctoral experience and build a strong career foundation, positioning me as an expert in the field of cell polarity.

Keywords: planar polarity,gravitropism,root development,membrane domains,trichoblasts,auxin
Modulation of Liver Metabolism/Inflammation at Different Disease Stages by Leveraging ADAR-based RNA Editing (HepaModulatoR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Israel
Call: ERC SYNERGY GRANTS (ERC-2025-SyG, 2025)
Start date: 2026-03-01
End date: 2032-02-29
Duration (months): 72.0
Total project cost (EUR): 9969748.0
EU funding (EUR): 9969748.0
Participants: 2
Project status: SIGNED

RNA base editing, catalyzed by ADAR enzymes, is a natural process that diversifies protein function by modifying mRNA. Redirecting ADAR activity with RNA-based drugs holds significant promise for correcting genetic mutations and uniquely enables precise modulation of protein function. However, major challenges remain to fully unlock this potential. In this collaborative effort, we present a target discovery platform and demonstrate in vivo proof-of-concept (PoC) that targeted RNA base editing can mitigate chronic liver disease. Our team combines its groundbreaking insights and tools to predict functional editing computationally (PI Levanon), efficiently screen for effective edits (PI Stafforst), and establish functional PoC in animal models of liver disease (PI Heikenwälder). Chronic liver disease stems from disturbances in the liver microenvironment caused by chronic viral infections, alcohol intake, sedentary life-style/high-calorie diets or autoimmunity, all disrupt hepatocyte metabolism and regulatory signalling. This ultimately leads to liver inflammation, fibrosis, and liver cancer. We suggest that targeted RNA base editing is well-suited to counteract liver disease by modulating protein function and upregulating hepatoprotective proteins. To maximize the likelihood of success, our team addresses three Focus Areas, each representing a distinct stage of liver disease: In Focus Area 1, we aim to modulate liver metabolism (promoting catabolism) at an early disease stage. In Focus Area 2, we seek to reduce chronic inflammatory signalling at the mid-stage. Finally, Focus Area 3 focuses on generating highly immunogenic neoantigens in cancerous liver tissue to stimulate immune therapies at advanced stages. Overall, this project will push far beyond the current state-of-the-art in this field, significantly advancing this innovative therapeutic modality. We aim to make a substantial impact on Europe’s society, healthcare systems, and pharmaceutical industry.

Keywords: adar,rna editing,rna drugs,base editing,chronic liver inflammation,mouse models liver disease,spatial metabolomics,masld,mash,liver cancer,neoantigen,rna editing prediction,rna structure prediction,computational biology,genomics transcriptomics,large language models,machine learning