Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ZebraZoom: Kinematic analysis for drug and genetic screening in zebrafish (ZebraZoom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-12-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

With millions of European citizens suffering from chronic pain and neurodegenerative disease, there is an urgent need for efficient solutions for drug screening in animal models. Discovery of new drugs and functions of genes involved in these human diseases relies on efficient ways to screen effects on animal behavior and at low cost. Zebrafish emerged in the last decade as an essential model for drug discovery as it is: i) a low cost genetic model organism whose genome shares 70% homology with human’s. ii) well-suited to fast and high throughput investigation of genes and molecules. iii) an ideal platform to study genes and pathways of relevance to disease in humans. Consequently, several companies are exploiting zebrafish research to devise new drugs for motor and neurological disorders. However, the current state of the art in commercial analysis of zebrafish behavior is limited to the analysis of crude parameters. In these conditions, the fast kinematics indicative of specific types of sensory and motor defects cannot be resolved. A fine kinematic analysis efficiently performed over large population of animals is crucial to reliably quantify defects in strength, posture or speed in mutant animals with and without with drug treatment. This accuracy is critical for concluding on the effects of drugs involved in motor functions, posture or pain. During her ERC starting grant OptoLoco, Dr. Wyart has developed ZebraZoom to resolve kinematic data with the necessary degree of resolution required for interpretation of motor defects. This approach enables the quantitative measurement of defects in speed, posture, and movement strength. In the ZebraZoom PoC, we will evaluate the market potential for a high-throughput method to quantify and categorise behavioural movements of zebrafish larvae/juveniles in response to drug administration and genetic manipulations and elaborate a marketing plan and business plan targeting for pharmaceutical companies and research labs.

Keywords: high throughput drug and genetic screening,zebrafish,locomotion
Tracking the Effects of Amyloid and Tau Pathology on Brain Systems and Cognition in Early Alzheimer’s Disease (TRACE-AD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

Alzheimer’s disease (AD) is a tremendous burden and there are still no therapies available. Most clinical trials have focused on the late disease stages where neuronal damage is already severe and irreversible. To intervene in earlier stages, it is essential to understand how AD pathology affects brain systems early in the disease. Beyond that, we need better markers to identify individuals at an early asymptomatic stage that will likely deteriorate in the coming years as well as measures of treatment response to assess the benefit of a treatment. I focus on two functional brain systems that are critical for memory in humans and are very early affected by AD pathology. With the powerful and novel combination of positron-emission-tomography and ultrahigh-field magnetic resonance imaging, I will unravel the early effects of AD pathology on brain connectivity and activity, grey matter loss and memory function within both brain systems. I will use a pseudo-longitudinal design to study changes in brain system integrity and memory during disease progression in the very early stages of AD. To identify predictive markers of progression, I will use monthly repeated smartphone-based assessments throughout one year to i) define cognitive trajectories of individual memory decline, ii) characterize stage-specific decline rates, and ii) determine the best cognitive and imaging markers for prediction of cognitive decline. Taken together, this proposal will result in a more profound understanding of the earliest stages of AD and provide novel markers that will improve patient selection as well as assessment of treatment response in future clinical AD trials. This will advance the development of new disease-modifying therapies and early clinical diagnosis. Importantly, realizing this proposal will provide critical training of scientific and transferable skills that are required to follow my research interests and to set up my own research group in the future.

Keywords: early alzheimer s disease,tau and amyloid pet imaging,ultrahigh field mri at 7t,mobile cognitive assessments,human object and scene memory,medial temporal lobe,hippocampus,entorhinal cortex
Dissecting GLP-1 receptor internalization pathways using genetic and pharmacological tools (INTERGLP1)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-17
End date: 2022-02-16
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Glucagon-like peptide-1 is a key regulator of insulin and blood glucose release. The cognate receptor, the glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR is a major drug target for type 2 diabetes. Agonist-induced internalization is a major regulatory mechanism for GPCR signalling. Interestingly, GLP-1R internalizes via a mechanism that is distinct from the canonical beta-arrestin mediated pathway. However, the details of the exact mechanism is largely conflicting and poorly understood for GPCRs in general. The present project aims to develop genetic and pharmacological tool box to dissecting the intracellular pathways leading to GLP-1R internalisation. To do this, I will generate a series of HEK293 cells where key proteins involved in a range of GPCR internalization pathways have been systematically removed by CRISPR/Cas9 genome editing. These cell lines will complement the already existing G protein alpha subunit and beta-arrestin knockout HEK293 cell lines to generate a highly efficient toolbox to study pathways and mechanisms involved in GPCR signalling, internalization and regulation. In the present project, I will utilise theses cell lines to dissect pathways leading to GLP-1R internalization and endosomal signalling. To understand the role of bias in the complex signalling profile of GPCR, I will also develop conformationally selective nanobodies using the yeast surface display platform. Importantly, we will make the cell lines and pharmacological tool compounds available to the scientific community enabling similar studies on a much wider range of GPCRs.

Keywords: gpcr,glp 1r,crispr,cas9 genome editing,internalization,endosomal signalling,nanobody
Evolution of Xylan Utilization Loci 's enzymes for the design of enzymatic assemblies (EvoXUL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-11
End date: 2023-01-10
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Lignocellulosic biomass (LCB) is a renewable and inexhaustible carbon source on Earth and its valorisation will drive sustainable circular bioeconomy. Microorganisms involved in LCB deconstruction produce a huge repertoire of carbohydrate active enzymes (CAZymes) in order to utilize LCB as carbon source. Specifically, Bacteroides, encode fine-tuned gene clusters dedicated to polysaccharide metabolism called Polysaccharide Utilization Loci (PUL). The host team recently discovered a xylan PUL from termite gut whose enzymes showed promising activity on different LCB. In EvoXUL project an original co-evolution strategy will be deployed to simultaneously engineer XUL’s enzymes towards wheat bran and wheat straw hydrolysis. In addition, a combination of enzyme assemblies will be created thanks to the Bio Molecular Welding Jo-In system to further maximize the synergy between the catalysts and to unravel the impact of enzyme spatial organization with the goal of developing more efficient enzyme cocktails for bioeconomy. The fellow and members of the French National Institute for Applied Sciences of Toulouse (INSA Toulouse) will establish a successful collaboration plan on the basis of their respective backgrounds in hydrolases involved in biomass valorisation (biochemistry, applied enzymology, bioprocess engineering) and protein evolution, engineering, and functional characterization of glycoside hydrolases, respectively. The acquired knowledge in structure and synergism of modular enzymes will provide rules for tailor made enzyme assemblies for future industrial applications related with lignocellulosic feedstock biorefinery. The project will provide an in depth training in molecular biology, protein engineering and structure-function of carbohydrate modifying enzymes.

Keywords: glycosyl transferases,enzyme co evolution,enzyme assemblies,xylan,lignocellulosic biomass
Disruptive Radar Positioning System for trains (RPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Knowing the exact location of trains is extremely important for railway industry, as it increases security, passenger safety and traffic capacity as well as reducing energy consumption and pollutant emissions. Our technology is more economical, more accurate, and safer than the current available train positioning solutions such as Eurobalises, odometers or Doppler Effect Cinemometers. The RPS solution is based on two devices, the RPS Radar which is a high-frequency radar installed on the train that obtains a detailed ground profile and the RPS Balises, a set of plastic pieces attached in certain railway sleepers. We seek to exploit RPS technology by marketing 2 different services. The first is our Efficient Speed Control service that will allow metro and railway operators to establish an optimal map of speeds for their trains. With this tool they will be able to adapt train speed to the optimal energy consumption instead of using sections at a constant speed as is currently done. The second is our Target Braking service that will allow signalling companies a smooth deceleration of the trains in stations until they stop at a precise point. With this tool they will be able to provide a greater comfort and safety to passengers, improve energy efficiency and deploy Platform Screen Doors reliably and at a low cost. Up to now, thanks to the effort and commitment of our valuable professional team, we have raised €720,000 from different agencies of the Spanish Government, we possess 9 patents, we have tested the core of our technology in a real environment with renowned customers such as Madrid Metro and Talgo, we have received awards from the technological and entrepreneurship sectors and we have established strong alliances and received the support of key stakeholders such as Indra and Renfe.

Keywords: radar positioning system,ertms,etcs,target braking,energy efficiency
Establishing services enhancing the innovation management capacity of Croatian SME's through the Enterprise Europe Network (SSBI-CRO-KAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Croatia,Croatia,Croatia,Croatia
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-05-01
End date: 2014-12-31
Duration (months): 8.0
Total project cost (EUR): 22542.5
EU funding (EUR): 18034.0
Participants: 5
Project status: CLOSED

Establishing services enhancing the innovation management capacity of SME's in the Enterprise Europe Network Croatia

Keywords: key account management,innovation coaching,sme instrument,enterprise europe network
First Operational, Secured and Trusted galilEo Receiver for ITS (FOSTER ITS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Innovation actions
Countries involved: Italy,Germany,France,France
Call: EGNSS applications (H2020-Galileo-2014-1, 2014)
Start date: 2015-01-01
End date: 2018-07-31
Duration (months): 43.0
Total project cost (EUR): 2590461.25
EU funding (EUR): 1813322.87
Participants: 5
Project status: CLOSED

The primary objective of FOSTER ITS is to design and develop the first secured GNSS module available on the market for ITS application. The FOSTER ITS products will be Galileo, EGNOS, GPS and GLONASS enabled and will offer greater resilience against the increasing range of GNSS threats by: • Detecting signal attack attempts (spoofing, meaconing and jamming); • Providing indicators to users about confidence of the positioning; • Providing proof of the integrity and origin of the PVT data (digital signature). The other ambition of FOSTER ITS project is to create a new ecosystem merging GNSS and Security. To reach these objectives, the FOSTER ITS secured GNSS module will: • Implement and enhance the Level Of Confidence IP (Intellectual Property) developed in the FP7 TACOT project; • Implement and enhance the Spoofing, Meaconing and Jamming detection IP developed in the FP7 TACOT project; • Add a secure Micro Controller Unit (MCU) to increase speed and robustness of security functions and ensure easiest security evaluation; • Implement Galileo OS Navigation Message Authentication Capability; • Target automotive grade and security evaluation; • Provide interface to support EDAS (EGNOS Data Access Service). In addition, the design of this secured module will natively allow further ITS security features in particular certificate and key cabinet that will be used in Vehicle-to-Vehicle and Vehicle-to-Infrastructure (V2X) communication (IEEE 1609.2 protocol). The FOSTER ITS Team consists of experienced companies and organisations which provides the most efficient background for the performance of the project. This consortium is composed of FDC, ST Microelectronics (Automotive and Security divisions), Novacom services and NavCert.

Keywords: galileo early services,security,trust,confidence,gnss module,authentication
Climate monitoring and seasonal forecast for global crop production (CLIM4CROP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-09
End date: 2020-11-08
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

When provided in a climate-services context, seasonal climate forecasts can enable a more effective adaptation to climate variability and change, offering an under-exploited opportunity to minimise the agricultural impacts of adverse climate conditions. However, the development of seasonal prediction systems of climate-driven impacts on agriculture is still largely in the early stages, especially on a global scale. CLIM4CROP is designed as a multidisciplinary project aimed at exploring how to best exploit seasonal forecasts for crop management decision making on a global scale. This goal will be achieved through three specific supporting objectives: a) characterising the uncertainties in global datasets of climate observations covering the last three decades and providing data in near-real time; b) understanding the role of climate as underlying mechanisms driving crop yields, and thereby developing statistical models linking climate and yields; c) exploring the seasonal predictability of crop yields with the above-mentioned developed models and implementing a model suite operationally using the data available in near-real time. These objectives will be addressed by making use of the latest advances in climate information, including the most complete and up-to-date sets of seasonal forecast systems. The expected outcomes of this project are an improved understanding of the interaction between climate and crop yields, and new insights allowing more efficient crop management. This could prove useful to policy-makers and commercial entities in their decision-making processes. To this end, the transfer of knowledge to impact users is envisaged.

Keywords: climate monitoring,crop yields,seasonal forecasts
OpenSMESearch (OSS) (OSS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

OSS (OpenSMESearch) aims to provide a platform to the online visibility problem facing by millions of micro SMEs in Europe. Despite they are regarded as the backbone of the European economy, important source for jobs, SMEs are losing online visibility with massive explosion of big data in the Internet era. This phenomenon is caused by two main factors: 1) more than 40% do not have a website yet and 2) they are not transparently shown in web searches, as the order of results is influenced by optimized, sponsored and paid business results. Therefore, small local businesses are suffering clear erosion in their individual sales, taxable sales for government revenue, which is based on local consumers (B2C) and services to other business (B2B). This problem is of vital relevance for the EU. OSS is our future flagship product based on pool of public and private data. OSS will be a dedicated search ecosystem for European SMEs, will provide transparent, relevant and global online visibility, facilitating the matching of business to consumers (B2C) and business to businesses (B2B), eliminating any disintermediation’s. OSS is crowd sourcing, ads free search model coupled with semantic database technologies built on the combination of both open and our private data sources. This product also has potential to extract commercial value from open data and increase private data profitability. The goal of OSS is to make local micro, SME knowledge globally visible in big data internet world. In this line, we present an analogy of our ambition. Wallet verses internet analogy: Big companies are like "Bank cards & bills" where as micro SMEs are like "coins". Most of the wallets are not having provision for coins likewise SME results are not getting enough visibility on global search platforms. Therefore, our aim is to be as a "SME source for global search engines (our existing clients)" (wallet: cards+coins) and at the same time as a "dedicated SME search platform" (just as a coin pocket wallets). The idea behind this project is to make OSS a global success, able to revolutionize the online visibility and search for SMEs, while allows us penetrate into the BIG DATA market, which is skyrocketing at a 35% CAGR. OSS is for the people by the people and to the people to make European SME local knowledge globally available.

Keywords: b2b search ecosystem,local businesses support,small and medium enterprises,data commercialization
Quality Management Investments for Energy Efficiency (QUEST)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Germany,Belgium,Sweden,France,Denmark
Call: Mainstreaming energy efficiency finance (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-06-01
End date: 2022-05-31
Duration (months): 36.0
Total project cost (EUR): 1502677.5
EU funding (EUR): 1502677.5
Participants: 9
Project status: CLOSED

The main goal of QUEST is to promote investments in Sustainability and Energy Efficiency by identifying and empirically risk-grading factors that influence performance. QUEST will develop a simple toolkit to evaluate these investments. It may be easily applied to all types of Sustainability and Energy Efficiency investments and covers project design-construction-operation risks. Financial institutions applying the QUEST toolkit will be able to reduce risk while significantly increasing investment. QUEST will identify and statistically classify Project Risk Factors (ex. energy consumption) as well as Quality Management service features (ex. energy measurement) to reduce the gap between predicted and real performance in operation by exploiting existing databases (e.g. De-risking Energy Efficiency Platform). QUEST will then create and promote a data-driven decision-making process, certifiable to ISO EN 17065 standards. This will help financial institutions improve risk premium calculations reliability. The core element will be a “Quality Management Impact” factor that represents the added value of quality management. QUEST facilitates risk-securitization of investments by: - Reducing loan costs by identifying the risk profile of investments and also reducing transaction costs - Reducing insurance costs via improved risk identification - Transparently securing funding scheme requirements for Energy Efficiency QUEST’s proposal aims at reaching 880 financial institutions and other stakeholders. Working on 12 pilot projects, QUEST seeks to trigger 1.5 GWh per year (4.000 GWhPE/per year 5 years after project ends) primary energy savings and generate 1 M€ (80M€ per year 5 years after project end) in additional finance for Energy Efficiency investments.

Keywords: quality management investments