Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Extending Coherence for Hardware-Driven Optimizations in Multicore Architectures (ECHO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2026-01-31
Duration (months): 77.0
Total project cost (EUR): 1999955.0
EU funding (EUR): 1999955.0
Participants: 1
Project status: SIGNED

Multicore processors are present nowadays in most digital devices, from smartphones to high-performance servers. The increasing computational power of these processors is essential for enabling many important emerging application domains such as big-data, media, medical, or scientific modeling. A fundamental technique to improve performance is speculation, a technique that consists in executing work before it is known if it is actually needed. In hardware, speculation significantly increases energy consumption by performing unnecessary operations, while speculation in software (e.g., compilers) is not the default thus preventing performance optimizations. Since performance in current multicores is limited by their power budget, it is imperative to make multicores as energy-efficient as possible to increase performance even further. In a multicore architecture, the cache coherence protocol is an essential component since its unique but challenging role is to offer a simple and unified view of the memory hierarchy. This project envisions that extending the role of the coherence protocol to simplify other system components will be the key to overcome the performance and energy limitations of current multicores. In particular, ECHO proposes to add simple but effective extensions to the cache coherence protocol in order to (i) reduce and even eliminate misspeculations at the processing cores and synchronization mechanisms and to (ii) enable speculative optimizations at compile time. The goal of this innovative approach is to improve the performance and energy efficiency of future multicore architectures. To accomplish the objectives proposed in this project, I will build on my 14 years expertise in cache coherence, documented in over 40 publications of high impact.

Keywords: cache coherence,processor design,synchronization mechanisms,compiler infrastructure,heterogeneous architectures
ADvanced Validation of A Novel TB Active disease diagnostic to address Global unmet needs: a European consortium approach (ADVANTAGE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Ireland,United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2019-03-31
Duration (months): 45.0
Total project cost (EUR): 3893307.5
EU funding (EUR): 3583396.0
Participants: 2
Project status: CLOSED

Tuberculosis (TB) remains an EU and global healthcare priority resulting in over 1.4 million deaths each year. Despite this and efforts to reduce TB by the EU commission, the WHO and others, a simple, rapid, diagnostic test for active tuberculosis (TB) remains elusive. Current diagnostic procedures, while accounting for over $1 bn globally, are poorly selective for active TB, hold risks for healthcare personnel, are slow to yield results and costly. The large potential and high unmet need provide a clear target for commercialisation of a point-of-care (POC) test. Using over 400 clinical samples, ProteinLogic (a UK based diagnostics company) have demonstrated proof of concept for a ground-breaking approach using a panel of protein biomarkers on human serum samples that profile the cell mediated patient response to TB. The objectives of the eight structured work packages within this three year project are to build on the validation of the biomarker TB panel transitioning from a laboratory assay to Biosensia’s novel microfluidic POC platform that has already been successfully proven with a variety of human analytes. Reagents will be developed as part of this project to ensure reduced costs and security of commercial supply. A unique instrument reader plus TB cartridge-based product will be developed to meet EU regulatory standards. The products will be validated in order to confirm analytical and clinical performance, and to provide evidence of major time, cost & performance improvements compared to current TB testing practises. Successful commercialisation will lead to the creation of over 30 new jobs and will stimulate further private investment in each of the companies. In summary, ADVANTAGE has the potential to deliver a disruptive POC TB diagnostic test that can help eradicate the massive TB burden not only in EU but also globally.

Keywords: active tuberculosis,biomarker
Detecting and characterizing exoplanets around evolved stars with NASA's TESS mission (PULSATION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

The Transiting Exoplanet Survey Satellite (TESS) is a NASA space mission, with launch scheduled for March 2018, that will perform an all-sky survey for planets transiting bright stars. Furthermore, TESS's excellent photometric precision, combined with its fine time sampling and long intervals of uninterrupted observations, will enable asteroseismology (i.e., the study of stars by the observation of their natural, resonant oscillations). Asteroseismology is proving to be particularly significant for the study of red-giant stars, while maturing into a powerful tool whose impact is being felt across different domains of astrophysics. A noticeable example is the synergy between asteroseismology and exoplanetary science. TESS hence offers the exciting prospect of conducting asteroseismology of evolved exoplanet-host stars. The research goal of this action is to use TESS photometry to systematically detect and characterize planets transiting oscillating evolved stars. To that end, we propose an interdisciplinary research project combining transit photometry, asteroseismology and radial-velocity/spectroscopic ground-based follow-up. The proposed research project is expected to provide new insight into some of the outstanding problems in exoplanetary science, namely, on the occurrence rate of gas-giant planets as a function of stellar mass, on the correlation between stellar metallicity and giant-planet occurrence around evolved stars, and on the structural aspects of gas-giant planets. Finally, we are also committed to improving public awareness of the increasingly engaging topic of exoplanets in the host organization's home country and, as part of this action, will develop an educational/outreach program in collaboration with a non-academic partner.

Keywords: asteroseismology,nasa tess satellite,transiting exoplanets,radial velocity follow up
Long-term molecular nanoscale imaging of neuronal function (MoNaLISA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 1725000.0
EU funding (EUR): 1725000.0
Participants: 1
Project status: CLOSED

Synaptic function is difficult to analyze in living neurons using conventional optics, since the synaptic organelles and protein clusters are small and tightly spaced. The solution to this problem can come from the field of super-resolution fluorescence microscopy, or nanoscopy. However, the current approaches to nanoscopy are still far from reaching this goal. Single molecule-based approaches (including STORM and PALM) provide high spatial resolution, but slow recording, insufficient for live imaging. Ensemble approaches (including SSIM and STED) are able to record faster, but with poorer resolution or with high, potentially toxic, laser powers. It is currently impossible to image the same neuron for hours and days, with both high spatial (~30 nm) and temporal (10-1000 Hz) resolution, and with minimal photodamage. My aim is to fill this gap, by developing, for the first time, a microscope that combines the advantages of both single molecule-based and ensemble approaches. I will base the microscope on RESOLFT, a low-photodamage ensemble approach that I have pioneered recently. I will use line patterns to speed up the recording and 2photon-switching for 3D ability. I will combine this with sensitive detection schemes that allow single-molecule detection and counting, relying on my previous expertise with PALM and GSDIM. The new set-up, termed molecular nanoscale long-term imaging with sequential acquisition (MoNaLISA), will track neuronal organelles and proteins on different time scales, spanning from milliseconds to days, with a resolution close to the molecular scale. To obtain the first proof-of-principle results, I will address several issues still open in the synaptic transmission field, relating to synaptic vesicle recycling, biogenesis and degradation. Overall, my project will introduce a novel paradigm to imaging in the life sciences, which will enable fast and quantitative nano-imaging of cells and tissues.

Keywords: super resolution fluorescence microscopy,nanoscopy,imaging,synaptic vesicle,resolft,fluorescence
Fundamental Studies in Catalysis – Reactivity Design with Experimental and Computational Tools (FunCatDesign)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1491875.0
EU funding (EUR): 1491875.0
Participants: 1
Project status: CLOSED

Catalysis is ubiquitous in modern academic and industrial chemistry as well as an integral and indispensable discipline that may contribute to solutions of current global challenges. While the field has grown significantly over the past few decades, with numerous transformations that were previously unthinkable now being possible, progress has frequently relied on serendipitous discoveries or elaborate screening efforts. Although it is indisputable that high-throughput screening is an extremely lucrative approach to generate a wealth of chemical information, the next frontier in the development of innovative approaches to meet the high demand for predictable, selective and sustainable processes will likely arise from fundamental insight. However, owing to the complexity of catalytic processes, the fleeting and frequently highly sensitive nature of intermediates and the associated challenges in gaining fundamental mechanistic understanding, insight-driven developments and especially reactivity designs have so far been extremely rare. The objective of this proposal is to capitalize on the tools of experimental and computational chemistry as a powerful means to gain access to the fundamental mechanistic details of key catalytic steps that are required to allow reactivity design. The specific subject for study will focus on the most significant challenges in nickel-catalysis - a highly promising area in the context of sustainability and synthetic diversity owing to nickel’s relatively large abundance and also high reactivities towards relatively inert bonds. The proposed studies will address challenges in relation to Ni-catalyzed C-H activation, cross-coupling and trifluoromethylation reactions, as well as the exploration of novel avenues in catalysis at multinuclear sites.

Keywords: catalysis,mechanistic studies,organometallic,reactivity design,physical organic chemistry,synthesis,nickel,c h activation,trifluoromethylation
Mining Sandboxes for Automatic App Protection (BOXMATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-09-01
End date: 2019-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Today’s industry is more vulnerable to cyberattacks than ever. The biggest threat comes from advanced persistent threats that targets the sensitive data of a specific company. Such a threat may come along as an innocuous app that starts its malicious behavior only when the mobile logs into the corporate network. At the same time, such threats can be made undetectable through testing or code analysis. The ERC SPECMATE project has developed a technology named BOXMATE that protects against unexpected changes of app behavior and thus drastically reduces the attack surface of mobile applications. The key idea is to mine app behavior by executing generated tests, systematically exploring the program’s accesses to sensitive data. During production, the app then is placed in a sandbox, which prohibits accesses not seen during testing. This combination of test generation and sandboxing effectively protects against advanced persistent threats. To access sensitive data during production, the app already must do so during testing—where tracing makes it easy to discover and assess. BOXMATE neither does not need to collect user data: All app behavior is assessed during testing already. Finally, BOXMATE requires no knowledge about source or binary code, and thus easily handles arbitrarily obfuscated or obscure third-party apps. BOXMATE is currently being patented worldwide. We want to turn the BOXMATE approach into a full mobile security solution for corporate and end users. This proposal aims at producing a full-fledged prototype that can be demonstrated to potential customers, most notably app vendors and mobile infrastructure providers; as well as developing an adequate marketing strategy exploring and responding to the needs of the market. This proposal is fueled by the principal investigator, Andreas Zeller, one of the world’s leading experts in software test generation and specification mining.

Keywords: mobile apps,access policies,sandboxes,policy inference,test generation
Virtual Environments for Social Training (VEST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Cyprus
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-04-01
End date: 2016-09-30
Duration (months): 18.0
Total project cost (EUR): 147687.5
EU funding (EUR): 147687.5
Participants: 1
Project status: CLOSED

Autism spectrum disorder (ASD) is a clinical diagnostic label used to characterize a wide array of individuals exhibiting some common degree of core difficulty in the domain of social communication. This difficulty is reflected in contextually inappropriate social behavior, limited understanding of social norms, expectations, and others’ mental states, eye gaze abnormalities, etc. Such impairments often lead to social exclusion and failure to develop age-appropriate peer relationships. Although current behavioral interventions for autism show some effectiveness, their generalizability is limited insofar as they are often set in structured settings that are decontextualized from situations of everyday life. Also, most of the interventions that have been effective tend to train skills that do not pertain to core areas of social communication where individuals with autism encounter difficulties (e.g. they target improvements in language, IQ etc.). To overcome the shortcomings of traditional interventions we have begun exploring how to train social skills through interactive role-playing scenarios experienced through immersive Virtual Reality (VR). With VR autistic individuals can practice, in realistic but safe environments, useful and typical tasks from everyday life. We have designed a prototype software package with a number of tasks embedded in virtual environments aiming at (1) capitalizing on known cognitive strengths of autistic individuals (e.g., good skills in visual search) and generalizing them to social settings, and (2) improving the transfer of skills across tasks that are conceptually similar despite surface differences. This software runs on a variety of platforms including low-cost Head-Mounted-Displays and 3D TVs. Based on what we know about autism and current interventions, with this PoC grant we aim to explore the potential of commercializing affordable software/hardware VR systems for social skills training in clinical settings and at home.

Keywords: virtual reality,virtual environments,autism
Space made easy. A personal satellite communication system for those who just need to stay connected. (SPACELOOP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Space Loop will be the first commercial personal satellite communication system in Low Earth Orbit developed and built in Europe. At Orbitare we realized that by circumventing the need for real time voice along with its technical complexities, we can create a new satellite communication solution much more efficiently than the conventional set-ups. Designed for those who just need to stay in touch, it will deliver messaging, email and file transfer capabilities to any location in the World, at the most competitive price and ease of use. Space Loop will give access to satellite communications to people who consider that the offering of Inmarsat, iridium or Globalstar is complex and prohibitively expensive. We see a business opportunity in entering the large market of satellite communications and challenging the few but big incumbents. We understand that the risks are of parallel magnitude and have a realistic plan to overcome them.
Photo/magnetic stimulated nanocargos for superior cancer treatments (NANOCARGO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Poland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 146462.4
EU funding (EUR): 146462.4
Participants: 1
Project status: CLOSED

Breast cancer (BC) accounts for 28 % of the total cancer cases in the European Union (EU) and is the leading cause of cancer-related mortality of European women. The stratification of individual BC sub-types for corresponding therapy modalities is poor. Therapy outcomes in several BC sub-types are unsatisfactory. Its diagnosis is marred by high proportion of false positives and the economic burden to healthcare systems is very high. To overcome this NANOCARGO will develop a simultaneous diagnosis and therapy (theranostics) approach based on a multimodal nanocomposite termed as nanocargos. The battle against cancer is much more effectively fought if it is aided by early detection and, potentially concurrent, efficient treatment. NANOCARGO, introduces a new paradigm that theranostics can be made far more effective if a multimodal action can be integrated by adding a plasmonic shell to a magnetic nanoparticle core. The plasmonic shell can be functionalized with the chemotherapeutic drugs and aptamars. Magnetic@gold and magnetic@silver type core/shell nanocargos can be conjugated with anticancer aptamer. These nanocargos can be stimulated by simultaneous application of magnetic hyperthermia and photonic therapy. Cellular delivery can benefit from photoporation. Anticancer therapy can thus be made much more effective through the multimodal actions of these nanocargos exposed to endo-luminal, minimally invasive optical stimulation and extra-corporeal magnetic resonance imaging based excitation. Such a combined will maximise the delivery of these nanocargos into tumor cells. The magnetic core is advantageous for a controlled delivery of aptamer through an externally applied magnetic field. Gold and silver shell will support aptamer attachment. X-ray computed Tomography (CT) imaging contrast of absorbing tumors will be better due to higher X-ray absorption of gold and silver.

Keywords: biomedical nanotechnology,magnetic nanoparticles,photothermal effect,photodynamic therapy,mri imaging,cancer therapy