Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Galileo Advanced features for Maritime domain: Breakthrough Applications for Safety and Security (GAMBAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Greece,Greece,France
Call: EGNSS applications fostering green, safe and smart mobility (H2020-SPACE-EGNSS-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2316363.75
EU funding (EUR): 1621454.63
Participants: 5
Project status: SIGNED

Galileo-based solutions for a better surveilled, safer and more secure sea Maritime transportation is a backbone of the worldwide economic growth, representing 80% of the worldwide merchant traffic, and a major domain of human and nature activity. The improvement of maritime safety and security has always been a major concern for the global community, and, in the last decades, the protection of environment and the resilience to climate change effects have also appeared in the overall scope. Considering the size of the maritime domain and the potentially large distances to coasts, the GNSS is a core technology of maritime systems. Getting the best possible information from on-board GNSS receivers and more generally GNSS applications (including Search-and-Rescue payloads and short-messaging capabilities of GNSS satellites) is then beneficial to the maritime community for a minimum additional investment. Galileo system is bringing new assets and functionalities, in particular compared to other GNSS constellations, which appears to be particularly relevant for the maritime community. The objective of the GAMBAS project is to highlight how Galileo specific features can benefit to maritime domain, to propose implementations and to support demonstrations and disseminations of associated services, for the benefit of maritime domain in terms of security, safety, protection of environment and resilience to major catastrophic events. The project will in particular address the modernization of SSAS Cospas-Sarsat anti-piracy beacon, with unique Galileo return-link features, and the development of solutions for rescue operators and for the vessels to use Galileo robustness to jamming and spoofing (including authentication) and the expected future Emergency Warning Service. The solution will be supported by demonstration at sea, in Europe (Greece and Spain) and outside Europe.

Keywords: maritime safety,maritime security,search and rescue sar,authentication os nma,ship security alert system ssas,return link service rls,emergency warning service ews
Mobilization of Olive GenRes through pre-breeding activities to face the future challenges and development of an intelligent interface to ensure a friendly information availability for end users (GEN4OLIVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Italy,Germany,Spain,Greece,Türkiye,Türkiye,France,Morocco
Call: Genetic resources and pre-breeding communities (H2020-SFS-2020-1, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 7385558.36
EU funding (EUR): 6998282.51
Participants: 16
Project status: SIGNED

Problems related to biodiversity loss are seriously affecting the olive sector, one of the most important cultivars from the cultural and economic point of view. Emerging diseases and climate change effects daily threaten this sector. The last dry seasons have caused the decrease of olive oil production up to 57%. The genetic erosion risk is present: there are more than 1,200 olive varieties worldwide, but just a 5% represent the total harvested area. Olive GenRes could be the key to solve these problems, but they remain largely unexplored. Big handicaps still hinder their exploitation, such as poor characterisation of olive varieties, scarce development of pre-breeding activities, and lack of collaboration between the Germplasm Banks (GBs) and breeders/farmers. GEN4OLIVE encompasses a wide, interdisciplinary and transdisciplinary consortium, which aims to leverage olive GenRes by bringing them to a higher level closer to breeders and markets. The overall goal of GEN4OLIVE is to accelerate the mobilization of olive GenRes and to foster pre-breeding activities by (1) developing a smart and user-friendly interface that will implement Artificial Intelligence utilities to leverage the olive GenRes resources; and (2) enhancing breeders and growers’ participation through the implementation of two open calls for supporting pre-breeding activities and breeding plans. GEN4OLIVE will develop collective pre-breeding activities aiming to in-depth characterize more than 500 worldwide varieties and 1000 wild and ancient genotypes around 5 topics: climate change, pests and diseases, production and quality, and modern planting systems. After integrating all results in the GEN4OLIVE interface, breeders and other end-users will have an effective tool for speeding up all kind of breeding programs. The combination of pre-breeding results with modern ICTs will enable the access of end-users to this valuable information.

Keywords: pre breeding,breeding,varieties,olive genetic resources,germplasm banks,wild olives,ancient olives,genotyping,phenotyping,progenitors,smart interface,machine learning
Five-Dimensional Localization Microscopy for Sub-Cellular Dynamics (5D-NanoTrack)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2024-04-30
Duration (months): 66.0
Total project cost (EUR): 1802500.0
EU funding (EUR): 1802500.0
Participants: 1
Project status: SIGNED

The sub-cellular processes that control the most critical aspects of life occur in three-dimensions (3D), and are intrinsically dynamic. While super-resolution microscopy has revolutionized cellular imaging in recent years, our current capability to observe the dynamics of life on the nanoscale is still extremely limited, due to inherent trade-offs between spatial, temporal and spectral resolution using existing approaches. We propose to develop and demonstrate an optical microscopy methodology that would enable live sub-cellular observation in unprecedented detail. Making use of multicolor 3D point-spread-function (PSF) engineering, a technique I have recently developed, we will be able to simultaneously track multiple markers inside live cells, at high speed and in five-dimensions (3D, time, and color). Multicolor 3D PSF engineering holds the potential of being a uniquely powerful method for 5D tracking. However, it is not yet applicable to live-cell imaging, due to significant bottlenecks in optical engineering and signal processing, which we plan to overcome in this project. Importantly, we will also demonstrate the efficacy of our method using a challenging biological application: real-time visualization of chromatin dynamics - the spatiotemporal organization of DNA. This is a highly suitable problem due to its fundamental importance, its role in a variety of cellular processes, and the lack of appropriate tools for studying it. The project is divided into 3 aims: 1. Technology development: diffractive-element design for multicolor 3D PSFs. 2. System design: volumetric tracking of dense emitters. 3. Live-cell measurements: chromatin dynamics. Looking ahead, here we create the imaging tools that pave the way towards the holy grail of chromatin visualization: dynamic observation of the 3D positions of the ~3 billion DNA base-pairs in a live human cell. Beyond that, our results will be applicable to numerous 3D micro/nanoscale tracking applications.

Keywords: fluorescence microscopy,single particle tracking,3d microscopy,localization microscopy,chromatin dynamics,live cell imaging
Clinical validation of the DiviTum assay in key European markets (CVDTEU)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Many cancer therapies fail due to inadequate prediction of patient-specific treatment responses. In addition, a large number of clinical trials fail due to a lack of predictive tools for optimal cohort selection. Biovica has developed a sensitive and precise assay for the measurement of a biomarker thymidine kinase (TK) from serum as an indicator of cell proliferation. Our assay technology has been clinically tested and has demonstrated beyond state-of-the-art capability compared to existing solutions due to its unprecedented sensitivity. This allows for previously unrealized capabilities in monitoring and prediction of therapy response for most common cancers. The unique selling point of our technology is the documented ability to reliably measure solid tumor proliferation from serum, thereby making it cheaper, more scalable and less invasive for the patient than industry standards. Our key customers are drug developers and clinicians who will use it for optimal cohort selection for clinical trials, and prediction of treatment response for patients respectively. However, in order to reach these customers, we require carrying out extensive clinical validations to demonstrate technological soundness. Europe represents the largest market for biomarker diagnostics due to a growing ageing population. We therefore aim to conduct clinical studies in key European markets with access to relevant bio-banks. In phase 1 of the proposed project, we will perform a feasibility study with focus on market related activities in Europe. Thereafter we aim to conduct clinical studies in selected European countries in partnership with clinicians. Our ambition is to become the industry standard for cancer proliferation measurement worldwide.

Keywords: cancer,serum
An integrated mulTidisciplinary appRoach towards a new generAtIon of aNtibiotics: Targeting function and cross-talk of bacterial Envelope proTein machineries (Train2Target)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Italy,Switzerland,Belgium,Switzerland,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 3931378.2
EU funding (EUR): 3931378.2
Participants: 17
Project status: CLOSED

Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens. The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads. The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification. Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.

Keywords: bacterial cell envelope,peptidoglycan,outer membrane,outer membrane proteins,lipopolysaccharide,protein protein interactions,antibiotics,antimicrobial resistance,antibacterials,lead compound
In search for endothelial mechanisms of TPO-induced neuroprotection (TONEURENDO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Poland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 146462.4
EU funding (EUR): 146462.4
Participants: 1
Project status: CLOSED

Ageing is recognized as one of the greatest social and economical challenges of the 21century for European societies. With, Vascular Cognitive Impairment (VCI) being one of the leading causes of age-related cognitive impairment and one of the major causes of disability in the elderly. Although, the concept of VCI was introduced in 1993, current treatment is limited to management of vascular risks and symptomatic pharmacotherapy targeting vascular dementia. The overall objective of this project is to fill the significant gap in early detection, prevention and treatment of VCI. This will be achieved by explaining microvascular mechanism of protective effects of thrombopoietin (TPO) in a novel unique mixed-risk animal model of VCI- specific to hypertension plus carotid-artery hypoperfusion (HH-VCI). Given increased number of progenitor endothelial cells after TPO treatment, it is hypothesizes that protective effect of TPO is mediated by endothelium. Furthermore, protective effect of TPO is expected to be caused by activation of neoangiogenesis, anti-inflammatory and vasoprotective mechanisms driven by TPO action on endothelial. This hypothesis will be tested in two stages first, in-vitro and second, in-vivo. In-vitro models, will be used to investigate endothelial response to TPO in terms of its modulation of inflammatory response angiogenic potential and vasoprotective mechanisms. In-vivo models of TPOR KO mice and HH-VCI mice will be used to validate and confirm mechanisms identified in in vitro stage of experiments.

Keywords: vascular cognitive impairment vci
Pan-European system with an efficient coordinated use of flexibilities for the integration of a large share of RES (EU-SysFlex)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Spain,Estonia,Ireland,Germany,Germany,Germany,Germany,Spain,Estonia,Italy,Italy,Spain,Belgium,Norway,Finland,Poland,Poland,Sweden,Belgium,Slovakia,Latvia,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,Portugal,Portugal,Portugal,United Kingdom
Call: Demonstration of system integration with smart transmission grid and storage technologies with increasing share of renewables (H2020-LCE-2017-SGS, 2017)
Start date: 2017-11-01
End date: 2022-02-28
Duration (months): 52.0
Total project cost (EUR): 26489895.25
EU funding (EUR): 20279863.72
Participants: 62
Project status: CLOSED

The overall objective is to ensure an efficient and sufficient level of system services are provided to facilitate meeting world leading levels of RES-E while maintaining the level of resilience that consumers and society have come to expect from the European electricity system. This requires defining the right amount of flexibility and system services to support transmission system operators using a threefold approach. Firstly, the technical needs of the pan-European system will be defined for scenarios with more than 50% RES-E in will be identified and translated to services and products to be delivered in an enhanced market design. Secondly, the electricity market design and regulation needs to be augmented to efficiently and effectively procure the appropriate combination of these system services. Thirdly, implicit and explicit barriers to competitive forces being applied need to be removed. This requires an in-depth understanding of all stakeholders’ roles (Generation and flexibility providers, Transmission system operators (TSO) and Distribution System Operators (DSO) and regulators) at all system levels (interconnected system, national transmission and distribution sub-systems and consumers). For doing so, EU-SysFlex joins a multidisciplinary team of 34 partners from 14 European countries, led by the (Transmission System Operators) TSOs representing four different synchronous systems that integrate the pan-European interconnected electricity system: EirGrid & SONI (Ireland), PSE (Poland), AST (Latvia), Elering (Estonia), supported by the necessary (Distribution System Operators) DSOs, technology providers, and research & experienced entities. In addition, a group of three other European TSOs: Fingrid (Finland), LitGrid (Lithuania) and Ceps (Czech Republic), will join the advisory board of the project, in addition to EDSO for Smart Grids and USEF, in order to help the project maximising its impact.

Keywords: flexibility system services and products,data management and ict technologies,cross border collaboration,electricity market design,needs of regulation,codes and standards
FUNCTIONAL BIOLOGY AND ECOLOGY OF PLANKTONIC MARINE FUNGI – Revealing the mechanistic basis of the roles of mycoplankton in the marine carbon cycle (MYCO-CARB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1960141.0
EU funding (EUR): 1960141.0
Participants: 1
Project status: SIGNED

Marine planktonic fungi (mycoplankton) have been largely ignored compared to other plankton groups, such as phytoplankton, especially the roles that they fulfil in marine ecosystems. My research has shown that mycoplankton are a major structural and functional component of coastal ecosystems that have been almost completely overlooked. I have shown that mycoplankton are a substantial proportion of plankton biomass and that saprotrophic mycoplankton are active in coastal ecosystems. Mycoplankton are also a major plankton group in the open ocean and dominate on marine snow particles. These studies demonstrate that fungi have potential roles in the marine carbon cycle including the biological carbon pump. The absence of fungi within a general view of the structure and function of the marine carbon cycle, including a lack of mechanistic understanding of saprotroph functional biology and ecology, represent major knowledge gaps in our understanding of marine ecosystems that must urgently be addressed. MYCO-CARB will address these knowledge gaps through an innovative programme of research. Research cruises at established marine observatories will make an unprecedented assessment of active mycoplankton diversity and abundance across a range of ecosystems; from surface coastal waters to the deep open ocean. Innovative approaches, including molecular ecology tools and ecosystem modelling, will establish the impact of fungal saprotrophs on the marine carbon cycle. A culture collection will be developed, informed by the field-based surveys of natural assemblages to produce ecologically-relevant model fungi. Complementary culture-dependent and -independent systems biology methodologies will determine the underpinning biological machinery of saprotrophic marine mycoplankton. Through the MYCO-CARB research programme, I will open the marine fungal ‘black box’, revealing marine mycoplankton functional biology and ecology, and establishing their roles in the marine carbon cycle.

Keywords: marine microbial ecology,fungal ecology
A 1Gpixel Camera to Open the Markets of Aerial Data Acquisition (Aerial BCP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France,United Kingdom
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-11-01
End date: 2020-04-30
Duration (months): 30.0
Total project cost (EUR): 2402922.5
EU funding (EUR): 1682045.7599999998
Participants: 2
Project status: CLOSED

IMAO is the current European leader in the aerial data acquisition market. Resolve Optics is a small company internationally recognised in lenses development and manufacturing. IMAO has developed for its own needs the largest worldwide camera, for aerial data acquisition. Its patented design, which associates three optical chambers, matrixes of sensors and specifically adapted lenses, represents a disruption in the field of aerial data acquisition. With such a design, IMAO has created a camera prototype with a 660Mpixel resolution, which can be further improved to reach 1Gpixel by 2020. Other large format cameras are limited to 250Mpixels and their design, due to optics and mechanical constraints, cannot allow a better resolution. This resolution opens up the market of aerial data acquisition. Flight time is reduced by 2. Data acquisition cost is cut by 4. Images can be shoot at higher altitude. Flights over cities will not need special authorisations any longer. Images for Google maps, construction sites and other needs will be more frequent, refreshed more frequently. Flights over large areas will be facilitated for mapping and surveillance. This resolution represents a technological and a usage gap in the market of aerial data acquisition. IMAO has already received several letters of interest from worldwide stakeholders in aerial data acquisition to participate in our Very Interested People program to benefit from our camera. The AERIAL BCP project objectives are to develop IMAO and Resolve Optics production and test capacities to supply cameras according to market demand. Pilot tests will be performed to optimise it and bootstrap our market access.

Keywords: camera,aerial data acquisition,optics,photogrammetry