Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
IT tools and methods for managing migration FLOWS (ITFLOWS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Strengthen security through border management
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Ireland,Italy,Germany,Germany,Belgium,Bulgaria,Greece,Greece,United Kingdom
Call: Human factors, and social, societal, and organisational aspects of border and external security (H2020-SU-SEC-2019, 2019)
Start date: 2020-09-01
End date: 2023-09-30
Duration (months): 37.0
Total project cost (EUR): 4871832.5
EU funding (EUR): 4871830.75
Participants: 15
Project status: SIGNED

Prediction and management of migration are a major challenge for the European Union and also for many different stakeholder groups that provide resources and assistance to migrants along their journey. Yet, in order to develop better strategies and instruments among policy makers and practitioners in the field of migration, we still need a deeper understanding of this phenomenon. ITFLOWS will generate novel insights on migration. The purpose of ITFLOWS is to provide accurate predictions and adequate management solutions of migration flows in the European Union in the phases of reception, relocation, settlement and integration of migration, according to a wide range of human factors and using multiple sources of information. These insights will be provided by an evidence-based ICT enabled solution (the EUMigraTool) and precise models. All solutions will have fitness for purpose continually validated by policy-makers and practitioners in cooperation with civil-society organisations in a dynamic and iterative process. ITFLOWS will propose tailor-made solutions for practitioners and policy makers for managing migration. On the one hand, the EUMigraTool targets first-line-practitioners, second-level reception organisations and municipalities. It will provide modular solutions based on the prediction of migration flows and the identification of risks of tensions between migrants and EU citizens. On the other hand, an in-depth analysis on drivers, patterns and choices of migration as well as public sentiment towards migration will lead to the drafting of adequate recommendations and good practices for policy makers, governments and EU institutions.

Keywords: prediction,migration flows,models,management,digital solutions,tool,research,policy recommendations,tension reduction,public sentiment,asylum,practitioners
NanoBio-inorganic generators for conversion of renewable chemical energy into electricity (NANOBIOENER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-07
End date: 2017-07-06
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Focused in the secure, clean and efficient energy challenges of Horizon 2020, NANOBIOENER (this project) proposes the development of novel bio-inorganic nanogenerators which produce electricity from renewable fuels. These systems are presented as an alternative to electrochemical-based fuel cells in order to generate electrical energy in an autonomously and efficient manner. In this context, a new hybrid system will merge biological machinery, which is able to transform a fuel into mechanic energy (pressure and vibration), with a piezoelectric nanogenerator (zinc oxide nanowires), which transforms mechanic energy into electricity. The mechanical stimuli of pressure and vibration will be generated through gas production from fuel. This reaction will be catalyzed by a biological machinery (coupled multi-enzymatic systems), integrated into the nanogenerator. These devises will produce electricity at microscopic scale, employing renewable fuel sources such as carbon dioxide and biomass, creating a zero-emissions process. This power generation system will allow several advantages over the current nanobiogenerators, namely: i) the employment of renewable fuels; ii) the independent and continuous production of electricity, in comparison with existing nanogenerators that depend on voluntary actions or random environmental stimuli; iii) the regulation of the production potential by the control of the enzymatic activity which is responsible for the mechanical stimuli. NANOBIOENER’s success will produce the first report of a bio-inorganic nanogenerator powered by renewable fuels to produce clean energy thus benefiting the sustainable development of the human society. This research program will provide to Dr. Velasco-Lozano a state-of the art training at the interface between chemistry and biology.

Keywords: biocatalysis,piezoelectric,multi enzyme systems,energy production
Resilience and Trigger Factors in Cardiac Arrhythmia: Risk Stratification and Drug Design (MOLEC ANTI-ARRHYT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2026-01-31
Duration (months): 71.0
Total project cost (EUR): 1499998.0
EU funding (EUR): 1499998.0
Participants: 1
Project status: SIGNED

Up to 30% of individuals with inherited cardiac arrhythmias such as Long QT syndrome are not protected from sudden cardiac death despite state-of-the-art treatment. A major hurdle for effective risk stratification and treatment of inherited cardiac arrhythmias is the poor correlation between genetic variant and clinical manifestations. Affected individuals, who harbour the same arrhythmia-causative mutation, paradoxically display a spectrum of clinical phenotypes ranging from a lifelong asymptomatic state to sudden death in infancy. Up to 40% of genotype-positive individuals, depending on type of arrhythmia, do not display clinical manifestation. Based on our unpublished observations, I propose that an important, yet unexplored, underlying cause of the diverse clinical manifestations are endogenous resilience and trigger factors, which interact with mutated cardiac ion channels to alter arrhythmia severity. MOLEC ANTI-ARRHYT utilizes front-line experimental and computational approaches and the cardiac IKs potassium channel, which is strongly linked to lethal arrhythmias and sudden cardiac death, as a prototype. We aim to: (i) identify major classes of endogenous ligands with therapeutic (resilience factors) or pathological (trigger factors) effects on the IKs channel, (ii) provide proof of mechanism for how the effect of resilience and trigger factors is determined by arrhythmia-causative mutations in the IKs channel, (iii) utilize resilience mechanisms to develop a fundamentally novel concept of anti-arrhythmic drug development: Resilience-Mimetic Drug Development. The successful completion of this project will open up new avenues for personalized risk stratification and clinical management, which ultimately will improve the clinical outcome for individuals with inherited arrhythmias.

Keywords: anti arrhythmic drug,electrophysiology,ion channel,long qt syndrome,molecular dynamics,voltage gated potassium channel
Discovering the cellular landscape of the airways and the lung (discovAIR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Switzerland,Sweden,Hungary,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Pilot actions to build the foundations of a human cell atlas (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2022-06-30
Duration (months): 30.0
Total project cost (EUR): 4958682.5
EU funding (EUR): 4958682.5
Participants: 18
Project status: CLOSED

Lung diseases are a leading cause of death, with increasing incidence and lack of curative interventions. The development of novel therapeutic interventions is hampered by our incomplete knowledge of the cellular complexity of the lung, as evidenced by the recent identification of the CFTR-expressing ionocyte. To overcome this limitation, we urgently need to acquire detailed knowledge of the cells of the lung, their fixed and variable molecular features, their interactions and their organization into macroscopic tissue architecture in health and disease. To achieve this, discovAIR aims to establish the first draft of the Human Lung Cell Atlas. Herein, discovAIR will combine multimodal molecular profiling of lung tissue cells with a detailed spatial mapping of the identified cell states, 3D reconstruction of lung tissue architecture, and in-depth molecular phenotyping of local cellular neighbourhoods. We will develop novel computational approaches to integrate the multilevel data of the spatial and the cellular branches of discovAIR. To identify the molecular phenotypes of cells in disease, discovAIR will include lung tissue from patients with asthma, COPD and IPF in the molecular profiling and spatial mapping effort. Moreover, discovAIR will chart cell state transitions from health to disease in a novel experimental approach, the lung cell perturbation map. The discovAIR results will be shared with the basic, translational and clinical scientific community as well as diagnostic and pharmaceutical industry through and open-access data visualization and exploration platform. For sustainability, this platform will be embedded in the Human Cell Atlas infrastructure. The discovAIR results will facilitate progress in regenerative and precision medicine and identify novel candidates for precision diagnostics and curative interventions in lung disease, thereby contributing to healthy ageing and active living in Europe.

Keywords: spatial mapping,cellular mapping,human lung cell atlas,technological,biological platform,precision medicine
Encoding, Absorption and Abandonment of Cultural Material during Migration: : The Case of Judeo-Spanish Songbooks (MigrEnAb)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

Since the 18th century throughout the Mediterranean basin Judeo-Spanish men and women have notated songs they want to remember in personal songbooks. Both Oriental (Ottoman Empire) and Occidental (North Africa & Gibraltar) Judeo-Spanish communities still have an enormous sung repertoire which plays a core function as identity marker. It is also centrally positioned for symbolic roles and gender negotiations. Historically, this repertoire was notated in songbooks which were created both for personal use or for transmission to their descendants. The porousness of repertoire found within these private books which function as objects of orality demonstrate the continued absorption and interpenetration of languages and cultural references during various centuries. Songbooks served as cultural reminders of the layered identities that Judeo-Spanish speakers sought to preserve. While keeping traditional repertoire, the writers of these songbooks simultaneously absorbed important musical elements from their surroundings, demonstrating a multiplicity of cultural codes that coexist dynamically. This continual construction of their seemingly opposing roles as preservers and innovators of repertoire breaks all attempts at strict regionalism, while ensuring that certain traditional specificities remain untouched and unchanged. The scholarship on these songbooks and their content has only been done on an individual basis, focusing on philology or ethnomusicological issues regarding contrafacta. This ground-breaking proposed study will analyze the individual songbooks as parts of a larger pan-Mediterranean corpus of Judeo-Spanish songbooks which negotiate identity transmission in an inclusive manner absorbing elements of the surrounding cultures while protecting the boundaries of the group. Through this study, I propose to elucidate transnational patterns of repertoire encoding, absorption and abandonment which can serve as a seminal theory for other mobile minority communities.

Keywords: music and society,intellectual history,judeo spanish,written orality
A neurally-informed behavioural modeling framework for examining individual and group difference in perceptual decision making (IndDecision)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1996310.0
EU funding (EUR): 1996310.0
Participants: 1
Project status: SIGNED

Pinpointing the mechanistic origins of inter-individual differences in decision making is a central goal of modern psychology and a considerable challenge because even elementary perceptual choices rely on a multitude of sensory, cognitive, motivational and motoric processes. For this reason, researchers have relied heavily on a set of mathematical ‘sequential sampling’ models that are designed to parse the latent psychological processes driving variations in choice behaviour. Although these models have been fruitfully employed in thousands of theoretical and neurophysiological investigations, they suffer from several limitations that particularly undermine their utility in inter-individual or -group comparisons including: A) parameter values are estimated on a relative, within-subject scale; B) the models come in many forms that can make identical behavioural predictions despite invoking fundamentally different mechanisms (‘model mimicry’); and C) they deal in abstract psychological constructs that are themselves dependent on multiple neural processes. The objective of this proposal is to address each of these issues by pioneering a ground-breaking decision modelling framework in which models are constructed and evaluated based on their ability to explain key observable aspects of the neural implementation of the human decision process in addition to its behavioural output. This ambitious goal is made possible by recent advances in non-invasive electrophysiology which enable direct observation, measurement and manipulation of the decision process as it unfolds in the human brain. Across a series of empirical investigations that will use adult aging as a test-bed for studying inter-individual and -group differences, this research will yield new methods for directly comparing model parameter values across subjects, resolve prominent theoretical debates regarding decision making algorithms and gain important new insights into their susceptibility to cognitive aging.

Keywords: perceptual decision making,sequential sampling models,electroencephalogram eeg
NEXT GENERATION OF ADVANCED COMPOSITE MATERIALS FOR SUSTAINABLE RETROFITTING OF STRUCTURES (THORAX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-08
End date: 2023-09-07
Duration (months): 24.0
Total project cost (EUR): 153085.44
EU funding (EUR): 153085.44
Participants: 1
Project status: SIGNED

Owing to the poor seismic design and the absence of strict energy performance regulations, the vast majority of the existing old building stock in seismic-prone areas is not only highly vulnerable to earthquakes, but also energy demanding. Currently, structural and energy retrofitting of buildings is treated separately with no established holistic approach. An integrated retrofitting system using advanced composite materials combined with thermal insulation can improve the seismic and energy performance of buildings and offer savings in application costs (>25%). During the last two decades, the use of fibre-reinforced composite materials for structural retrofitting applications has gained popularity. The recent generations of advanced composites for construction have proven to be very effective in seismic retrofitting of structures. However, they are often expensive, lead to incompatibility issues, and promote the use of cement-based binders, of which the production largely contributes to the global CO2 emissions (5% of global man-made CO2 emissions). The main objective of THORAX is to develop the next generation of sustainable fibre-reinforced composite materials to be used for the combined structural and energy retrofitting of buildings, protecting the residents during earthquakes, whilst increasing their energy performance. The efficiency of this novel retrofitting system will be investigated through a multi-scale experimental campaign accompanied with a detailed numerical investigation. The host organisation has a leading expertise in the fields of fibre-reinforced composites and seismic retrofitting techniques. This project, along with training schemes available at the host university and secondment at a word-class research centre, will create great opportunities for the Fellow to develop his career as an independent researcher.

Keywords: strengthening,rehabilitation,geopolymers,masonry infills,composite materials,energy retrofitting
Molecular evidence for lifestyle habits (Lifestyle Analytics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

The World Health Organisation (WHO) is spearheading the promotion of healthy diets and increased physical activity as it claims that these are the leading factors affecting health and well-being in Western countries. This claim rests on numerous clinical studies which linked lifestyle-related factors (e.g. nutrition, physical activity, smoking) to good or bad health outcomes. Corresponding data are generally based on questionnaires, and the usefulness of these data strongly relies on the honesty of participants and how well they remember past exposures. However, it is known that when it comes to lifestyle, participants tend to overestimate habits that are generally considered as ‘good’ and, in turn, underestimate those that are considered as ‘bad’. There is thus a need for more objective research methods to measure these habits in order to gain better and more reliable insights in how they affect our health. Such methods can furthermore become valuable tools in clinical practice by contributing to the prevention or even treatment of diseases through lifestyle changes. In this project, I aim to identify low-molecular-weight compounds, including metabolites, nutrients, and toxicants, that associate with lifestyle-related parameters using state-of-the-art ‘metabolomics’ techniques. For promising compounds or compound combinations, I will then develop high-throughput, targeted methods and validate them according to regulatory standards. These methods can subsequently mature to clinical-grade laboratory tests which would help in cutting health care costs and improving health and well-being. At last, for the proposed work I will be carrying out an innovative project at a top-level European university. I will accordingly be granted the opportunity to gain new experiences, learn new techniques, expand my network, and mature as scientific researcher which will support me in my ambition to become an independent research group leader in the near future.

Keywords: lifestyle,preventive medicine
Nanoporous and Nanostructured Materials for Medical Applications (NanoMed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ukraine,Spain,Greece,Hungary,Moldova, Republic of,Slovakia,France,Kazakhstan,Portugal,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-10-31
Duration (months): 70.0
Total project cost (EUR): 972000.0
EU funding (EUR): 972000.0
Participants: 13
Project status: CLOSED

This project aims to stimulate intersectoral and international collaboration within Europe and with an ICPC country, Kazakhstan, in the area of novel nanoporous and nanostructured adsorbents for the treatment of very serious health conditions associated with acute and chronic exposure to external radiation and uptake of heavy metals and radiation as a consequence of accidental, occupational or deliberate activities and events. This can dramatically lower the quality of life of the people affected and at present the treatment available is costly and inefficient. Radioactive contamination is a particularly serious problem in two of the countries participating in this project, namely, Ukraine and Kazakhstan, on large territories of the Chernobyl zone and around Semipalatinsk nuclear test site, respectively. A large number of people are affected by living in the areas with elevated level of radioactivity with uncertain long-term consequences to their health and the health of future generations. The expected impact of the project results is development of efficient and cost-effective methods of protection of first responders, population and cancer patients treated with radiotherapy from elevated doses of external and incorporated radiation and for occupational health protection of personnel working and the population living in areas contaminated with heavy metals.

Keywords: nanoporous materials,heavy metals uptake,radioactive contamination,haemoperfusion,oral,sorbents