Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Crossing Borders: The Agency of Nineteenth-Century European Theatre Migrants (T-MIGRANTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-09-01
End date: 2026-08-31
Duration (months): 72.0
Total project cost (EUR): 1499813.0
EU funding (EUR): 1499813.0
Participants: 1
Project status: SIGNED

How do migrants influence culture, its institutions and the production of the art? How does the migration process feed back into the migrants’ mind-sets, activities and social relations? These are pivotal questions today as in the past. The nineteenth century was a period of significant mass migration, and theatre – one of the mass media of the day – was profoundly affected by it. T-MIGRANTS will carry out the first systematic and in-depth analysis of nineteenth-century European theatre migrants. By reclaiming and positioning this group of agents, which has largely been ignored by national theatre historiographies, and by stressing their crucial but hitherto neglected influence on processes of modernity and global entanglement within theatre in and beyond Europe, the project will open up new ways of evaluating the influence of migration on culture and its institutions. Focusing on three geographic areas (Europe, the USA and South America), the project has three main objectives: 1. To systematically collect, analyse and make digitally accessible a new stock of data on nineteenth-century migrants, their theatrical work and their international networks. 2. To contextualise European theatre migrants within the migration processes of the nineteenth century. 3. To investigate the pivotal consequences of theatre migrants on institutional and aesthetical level, including significant impulses towards cross-cultural flows and tensions within the theatre business. Utilising a combination of previously unexamined archival material, comparative approaches and cutting-edge methods of digital humanities, T-MIGRANTS will revise established national narratives in theatre historiography, providing the crucial momentum towards a transnational history of theatre. It will make a substantial contribution to our understanding of historical and contemporary discourses on migration processes, integration and cultural identity and to the question of the cultural self-conception of Europe.

Keywords: theatre,migration,transnational history,nineteenth century
Novel nanometrically structured therapeutic hydrogel as injectable for fascial tissues surrounding the nerves intended for preventive treatment of chronic pain (TherGelFas)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The key goals of the “TherGeLFas” project are: (a) the training of a talented experienced researcher in the fast growing field of innovative biomaterials for medical applications where the host and partner institutions have a critical knowledge and expertise; and, (b) the design and development of cost- efficient polymer materials in order to develop a new medicinal product for post-operative acute pain treatment and prevention of chronification. The aim of the research project and the main scientific challenge is thereby to develop a ‘therapeutically effective’ hydrogel based injectable product to be applied during and post-surgery in the fascial tissue that protects the nerves where the pain originates and chronifies. TherGelFas expects to create the proof of concept of a new medicinal product by combining advanced materials (a biodegradable, antiseptic and biocompatible carrier, made of porous nanostructured hydrogel based on hyaluronic acid) with the ability to load and release non-steroidal antiinflamatory drugs in a controlled manner. It is aimed for the improvement of the current multimodal strategies of peripheral nerve blockade injections used during and post-surgery in acute pain treatment to prevent it from becoming chronic and that unfortunately are unsuccessful many times. The first achievement will be that of the training of the experienced researcher in new areas of knowledge such as business development from original concept stages to production scale-up, manufacturing and marketing stages. The second achievement will be to scientifically assess whether these hydrogels can improve and replace currently used therapies, to develop a proof-of-concept scalable product. The third achievement will be to learn how to perform correctly the necessary steps needed to launch a product of this kind, such as record and prepare all the documentation needed to present the product to the corresponding regulatory agencies.

Keywords: hydrogel,nanostructures,controlled drug release,pain management
The International Rebel Integration Toolkit Revisited: What Approaches Work for the Successful and Sustainable Incorporation of Former Rebel Groups after Civil War? (KW Rebel Integration)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-12-29
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

My post-doctoral research proposal, entitled The International Rebel Integration Toolkit Revisited: What Approaches Work for the Successful and Sustainable Incorporation of Former Rebel Groups after Civil War?, aims to compare the contents and combinations of three different – though not mutually exclusive – approaches to the integration of rebel groups in societies emerging from conflict: civilian (through Disarmament, Demobilization and Reintegration), military (as reflected in the incorporation of former combatants into the national army through the broader objective of Security Sector Reform) as well as political integration (as illustrated in the inclusion of rebel groups in interim governments, political power-sharing agreements or rebel-to-party transformations). Civilian, military and political integration provisions have become an integral part of what has commonly become referred to as the liberal peacebuilding paradigm, an approach rooted in the conviction that the promotion of specific peace accord measures coupled with democratization provides the most effective way to pacify conflict-torn societies. And while many UN peacekeeping missions are mandated to assist countries emerging from conflict in the implementation of these provisions, which provide strategic incentives to former armed groups against returning to armed struggle, the overall evidence is mixed when it comes to evaluating their success. What shapes the content and combination of civilian, military and political integration provisions in peace accords? What combinations have resulted in lasting peace and why? How do local and international actors view these various measures? How do they attempt to strategically use them to seek leverage? What are the consequences of these strategies for sustainable peace? The project will adopt a mixed-method approach combining quantitative and qualitative research methods to address these questions.

Keywords: civil wars,political violence,rebel groups,political parties,peacebuilding,political transitions,democracy
Advancing Innovative Stem Cell-based Therapy for Diabetes in Europe (ISLET)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Belgium,France,Netherlands,Denmark
Call: Regenerative medicine: from new insights to new applications (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 7999998.75
EU funding (EUR): 7999998.75
Participants: 9
Project status: SIGNED

Type 1 diabetes (T1D) is one of the main health challenges, with 6 million European citizens affected. Today, T1D accounts for a severe economic burden on healthcare and labour force. To bring advanced therapy in type T1D to patients, a scalable source of pancreatic islets for transplantation is needed. The objective of the ISLET project is to build and implement a new and innovative program for the production and marketing of human pluripotent stem cell (hPSC)-derived advanced therapy medicinal products (ATMPs) for treatment of EU citizens with T1D. To achieve this, ISLET gathers a constellation of experts to establish a transferable GMP-compliant manufacturing program based on improved and standardised protocols for generation and characterisation of future ATMPs. Furthermore, to make a product closer to the “golden standard” human pancreatic islet, ISLET will develop islet-like clusters composed of isolated hPSC-derived alpha and beta-like cells, and advance strategies for safe, up-scaled production and a quantitative go/no-go assessment of therapeutic quality. Specifically, to overcome the lack of robust qualitative and quantitative assays to assess islet function, ISLET will introduce a novel quality control concept for predicting the therapeutic efficacy by quantitative proteomics and lipidomics as part of the ATMP development chain - a concept that will be widely applicable. A commercial route for exploitation of hESC-derived ATMPs for T1D treatment with EU will be developed. Finally, a professionally supported dual plan for public engagement in the fields of stem cell therapy and diabetes is rounding up the project.

Keywords: type 1 diabetes,human pluripotent stem cells,atmp,gmp manufacturing program,insulin,beta cells,islets,atmp quality control,omics,exploitation
Innovative and affordable service for the Preventive Conservation monitoring of individual Cultural Artefacts during display, storage, handling and transport (CollectionCare)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Italy,Spain,Spain,Spain,Greece,Poland,Poland,Belgium,Latvia,France,Netherlands,Netherlands,Denmark
Call: Innovative and affordable solutions for the preventive conservation of cultural heritage (IA) (H2020-NMBP-ST-IND-2018, 2018)
Start date: 2019-03-01
End date: 2022-06-30
Duration (months): 40.0
Total project cost (EUR): 6239690.01
EU funding (EUR): 5759193.13
Participants: 19
Project status: SIGNED

Degradation of a cultural artefact depends on the environmental stress over time, especially during fluctuating environmental conditions, and the reactive behaviours of the materials of its composition. For an effective preventive conservation (PC) it is key to consider the historic environmental stress and degradation kinetics of the different materials (and their synergies) and monitor the artefact at all times. However, due to the heterogeneity of the material nature of the artefacts, this requires expensive monitoring as well as specialized personnel, out of reach for most, small to medium sized museums. CollectionCare will develop an innovative PC decision support system targeting the needs of small-medium sized museums. It will integrate IoT monitoring of the microclimatology of each artefact at any place, either at display, storage, handling or transport, integrated with multi-scale modelling for the different artefact materials while complying with current PC norms and recommendations. We will integrate latest advances in sensoring electronics, LPWAN wireless communication, multi-scale and multi-material degradation knowledge, big data and cloud computing into a single affordable system, adapted to the specific needs and resources of small museums and collections. The solution will built on the knowledge of different renown research groups and companies in the fields of PC (KADK, TU/e, LSIWC, UW, URO1, JHI and UPV), cloud computing and big data (ATOS), IoT connectivity (SGF), wireless sensoring (UPV, URO1), artefact transport (CBC, HvK), collection management (PS) as well as a large number of museums to guarantee future market acceptance (DFA-Spain, KMKG-Belgium, IVC-Spain, OAML-Latvia, IEEE-Greece, RDC-Denmark). The project will also count on a strong International Cooperation by an external Advisory Board of experts with prominent professional background from prestigious institutions and enterprises like: GCI, CCI, ICCROM, ICOMOS, Hispania Nostra and AXA ART.

Keywords: affordable pc,artefacts degradation,individual artefact monitoring,multi scale modelling,multi material analysis,sensoring electronics,decision support systems,cloud computing
Transnational Corporations and the Shifting Boundaries of Justice (TRANSCORP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

TRANSCORP aims to advance our understanding of the changing interface between business and society by analyzing the judicialisation of corporate social responsibility (CSR) – a phenomenon that is increasingly observed in the European Union, and notably in France, where the recent adoption of the ‘duty of vigilance’ law has opened the prospect that transnational corporations could be sued by third-parties for not taking sufficiently into account the risks generated by industrial activities across their production chains. While CSR had long been considered a matter of voluntary issue for private businesses, the on-going hardening of soft law remains an under-researched topic. This project aims to address this gap, by exploring how the agencies of a variety of state and non-state actors – such as transnational corporations (TNCs), non-governmental organizations (NGOs), supranational institutions (EU, OECD) – intersect at different levels in the production of transnational legal cases that encapsulate competing claims for justice. The main contribution of TRANSCORP will be to investigate this ‘judicialisation turn’ as mirroring the overarching institutional significance that TNCs have acquired in a world power system that has become increasingly fragmented. This will help us to develop a fine-grained description of how the ‘hybrid sovereignty’ that these private entities had consolidated for themselves in a few decades of globalization has become more and more contested as human societies are faced with both an explosion of social inequality and a worrying disruption of planetary equilibriums.

Keywords: transnational corporations,corporate social responsibility,global governance,social and environmental movements
Ocean-Bottom Distributed Acoustic Sensors: new tools for Underwater Seismology (Ocean-DAS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

One of the greatest outstanding challenges in seismology is the sparsity of instrumentation across Earth’s oceans. Poor spatial coverage results in biases and low-resolution regions in global tomography models as well as significant location uncertainty for offshore seismicity. Also, the lack of significant seismic instrumentation offshore makes it more complicated to have reliable early warning systems capable of mitigating some of the disastrous consequences of tsunamis. Ocean-bottom seismometers (OBS) are indeed available, but they are generally very expensive and limited by rapid data telemetry and battery life except in near-shore environments. The aim of this proposal is to provide a low-cost deployable solution (basically inexistent so far) for monitoring seismicity in remote areas of the ocean. The idea would be to retrofit existing telecommunication optical fiber cables lying in the ocean and transform them (with no basic change in the cable itself) into powerful seismic sensing arrays. With a single optoelectronic unit in the end of the cable (onshore), a full span of 50 km or more could be monitored, with thousands of measuring points interrogated. The proposed solution would be much cheaper than current alternatives and could easily allow deploying a large number of these sensor arrays, particularly in currently unmonitored areas. Moreover, all the fibre-optic cables used worldwide for communications are suitable for our proposed sensor, hence the same installation methodology could be exported to a large number of scenarios. The proposed solution has been pinpointed by prestigious seismology laboratories worldwide (Caltech Seismology Lab, GFZ Postdam, GeoAzur Nice) as a system with a great potential for adoption in the seismological field. A suitable demonstrator will be developed along the project and will be field tested in collaboration with GeoAzur Nice, in an underwater cable in the coast of Greece.

Keywords: ocean bottom seismometry,distributed optical fibre sensors,early warning of tsunamis
Colon Cancer Breath Screening using Nanowire-SERS (CanSENS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-06
End date: 2024-09-15
Duration (months): 24.0
Total project cost (EUR): 145941.12
EU funding (EUR): 145941.12
Participants: 1
Project status: SIGNED

Conventional techniques for detecting colon cancer (CoC), such as colonoscopy, are invasive, costly, and time-consuming. Volatile Organic Compound (VOC) detection in patients’ breath, has emerged as a new non-invasive method to diagnose and assess cancer at early stages. The CanSENS project aims at the development of a non-invasive and cost-effective breath analysis sensor platform for early-stage CoC screening, based on Surface-Enhanced Raman Spectroscopy (SERS). The proposed objectives include the fabrication of a prototype SERS sensor with high sensitivity, selectivity, and specificity; the development of a numerical chemometric model to identify the target VOCs of CoC; and clinical validation via breath samples of cancer patients versus healthy individuals, allowing multivariate analysis. These objectives will be achieved by incorporating novel single-dimensional nanomaterials for strong and quantitative SERS signal, which will further enhance the Raman sensing capabilities. In order to increase the overall sensing surface area of the device (i.e. the SERS ‘hot spots’) and enable the detection of VOCs at low concentrations, the nanostructures will be self-assembled into networks using state-of-the-art printed electronic techniques, including dielectrophoresis. SERS-based chemometric analysis will be performed on patients’ breath samples, providing an understanding of the complex relationship between the VOC profile and CoC occurrence. This project is multidisciplinary and includes aspects of engineering, chemistry, and clinical diagnostics. The fellow will work closely with experts in both academic and clinical sectors, for the development of a universal breath analysis platform that can potentially be expanded to detect other cancers.

Keywords: sers,spectroscopy,vocs,colon cancer,cancer screening,nanotechnology
Synaptic input mapping during cortical map plasticity (iMAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-15
End date: 2023-04-14
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

The rodent primary somatosensory cortex (S1) contains a malleable topographic map, in which cortical columns functionally represent individual facial whiskers. When all whiskers but two are trimmed, the cortical representations of the two spared whiskers partially fuse. This fusion is associated and possibly facilitated by an increase in NMDAR-mediated dendritic nonlinearities (plateau potentials) in L2/3 neurons, which are dependent on inputs from the higher-order posteromedial thalamic complex (POm). It has been shown that plateau potentials generated by these inputs can promote plasticity of sensory-related synaptic inputs. However, the spatiotemporal relationships between the plateau potential-generating POm and the sensory-related synaptic inputs on L2/3 neurons, and possible rearrangements therein during plasticity, are not understood. Recently developed genetically encoded glutamate indicators (GEGIs), which the fellow was involved in, have enabled the visualization of active excitatory inputs. Here, the fellow proposes a novel methodology (iMAC, Input Mapping of Active Connections), where she combines two state-of-the-art optogenetics and optophysiology tools. A presynaptic light-sensitive opsin will allow optical activation of ascending POm inputs, while a postsynaptic GEGI will allow the visualization, i.e. mapping of the activated synapses on L2/3 pyramidal neurons. First, the fellow will establish a proto-map of these higher-order thalamocortical excitatory inputs in an ex vivo preparation, followed by a proof of principle in vivo in the awake mouse. Second, the fellow will compare the POm-driven synaptic maps with those recruited by whisker sensory stimulation in vivo. Third, she will determine how these rearrange upon sensory deprivation. Altogether, this work will investigate the spatiotemporal relationships between POm and sensory-driven inputs onto L2/3 neurons and reveal possible rearrangements therein related to cortical map plasticity.

Keywords: mouse somatosensory cortex,cortical synaptic plasticity,synaptic input mapping,glutamate sensors,higher order thalamus