Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Restoring organ microphysiology via intravital ultracompact biopriniting endoscope (CORE-3D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Minimally invasive diagnostic and surgical tools have become a staple in modern medical routines worldwide. Endoscopes, a few millimeters in size, are inserted directly into the organ or cavities inside the body, allowing for high precision and fewer trauma-containing procedures. So far, these minimally invasive procedures have been limited to conventional micro-optical imaging and micro-mechanical surgical routines, such as cutting and making small incisions. Ideally, any medical intervention should be capable of re-creating intact biological ultra-structure and function directly at the target site following the most relevant cytocompatible approaches. This proposal seeks to implement noninvasive methods yield to obtain safeguarded, integrated, and improved cutting-edge additive and subtractive 3D manufacturing technologies for developing a miniaturized endoscopic device for organ structure and function intravital regeneration.

Keywords: ultracompact 3d optofluidic,intravital bioprinting,femtosecond laser ablation,nanothermometry,reactive oxygen species,
Water Data Management Ecosystem for Water Data Spaces (Waterverse)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Greece,Spain,Netherlands,Finland,Germany,United Kingdom,Italy,Cyprus,France,Belgium
Call: Technologies for data management (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2021-DATA-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 5253964.65
EU funding (EUR): 4510509.9
Participants: 19
Project status: SIGNED

The WATERVERSE mission is to develop a Water Data Management Ecosystem (WDME) for making data management practices and resources in the water sector accessible, affordable, secure, fair, and easy to use, improving usability of data and the interoperability of data-intensive processes, thus lowering the entry barrier to data spaces, enhancing the resilience of water utilities and boosting the perceived value of data and therefore the market opportunities behind it. WATERVERSE takes a holistic, interdisciplinary approach in the water domain, blending together complementary competencies of 17 partners located in 10 EU countries, representing the water domain with Research organisations (including social sciences experts), water utilities, water domain technology providers and innovation companies, as well as the technical community that is driving the development of data spaces, thus increasing the resilience of the water sector and water utilities, as a whole. The project will: (a) Actively engage end-users and stakeholders to assess the main gaps and challenges the water sector must overcome to effectively be part of and contribute to quality European data spaces; (b) Identify, extend, and integrate a wide set of data management tools to implement the WDME, based on FIWARE (www.fiware.org) Building Blocks and comprising tools and methods to ensure security and energy efficiency of the whole WDME; (c) Setup and demonstrate the WATERVERSE WDME in real environment with relevant and diverse case studies involving water sector stakeholders from 6 countries (Cyprus, Spain, Germany, the Netherlands, Finland, United Kingdom); (d) Set clear and measurable indicators for assessing FAIRness of data in water-related data spaces; (e) Ensure the viability and sustainability of the WATERVERSE WDME, as well as its replicability, scalability and business applicability.

Keywords: data spaces,fiware,water sector
METAMORPHOSIS (METAMORPHOSIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Czechia
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 299375.0
EU funding (EUR): 299375.0
Participants: 18
Project status: SIGNED

The Researchers´ Night is one of the favorite science popularization events in the Czech Republic. Since its introduction in 2005, it has steadily grown in terms of scope, geographical coverage, professionalization, and attendance by the public. The consortium of 18 participating universities, research institutes, and other non-academic organizations will prepare two editions of nation-wide ERN in collaboration with numerous stakeholders spread across the country. As in previous years the program is built around a shared topic: „Franz Kafka“ in 2024 and „Golden Coins” in 2025. For maximum reach to the relevant target groups, a coordinated awareness campaign including a common website, emblem, and graphic design will be carried out as well as impact evaluation. The key novelty will be introduced via the Researchers at Schools Activity (RaSA), reaching out to schools in remote areas. In 2024, researchers will visit schools with interactive sessions and school groups will be brought to experience ERN at one of the METAMORPHOSIS partners, while in 2025 the schools will be supported in organizing their own “mini Researchers´ Nights”. Based on the long-term experience of some of the project partners with bringing researchers to primary and secondary schools, an open-source handbook will be created. The conference for science popularizers will provide enthusiastic researchers with the necessary skills and a platform for sharing ideas. Researchers involved in EU-funded projects, including MSCA fellows and ERC grantees, and Erasmus students will help present the benefits of the EU support to science and innovation. Outreach activities will be also focused on raising awareness about EU missions. In addition, two gender-imbalanced STEM fields will be flagged, promoting “Girls in IT” and “Boys in primary school teaching”. Thanks to the inclusion of the Czech Centers in several European cities, the METAMORPHOSIS network will foster cooperation and promote Czech science abroad.

Keywords: science popularization,metamorphosis,kafka,researchers to schools,researchers night
Reinforcing the Scientific Excellence of the Institute for Ethnopharmacological Studies and Phytotherapy (IESP) through Twinning with Computer Science (CS) (ETHCSTWIN)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Greece,Germany,Italy,Kosovo
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1576035.71
EU funding (EUR): 1496750.0
Participants: 5
Project status: SIGNED

The main goal of the “ETHCSTWIN'' initiative is to establish a collaborative network between the Institute for Ethnopharmacological Studies and Phytotherapy (IESP / NKUA University) with two highly renowned academic research teams from Italy (Research team of Prof. A. Pieroni) and Germany (Research team of Prof. M. Hofmann-Apitius), as well as Biotech SME PangeaAI and Uni. of Prishtina (Faculty of Mathematics and Natural Sciences) in order to incorporate ETH insights into novel computational and digital frameworks by focusing on developing a rich portfolio of complex methodologies and tools, encompassing the analysis of extensive big data sets and the restoration of both tangible and intangible heritage. Following thorough research and assessment of data derived from several ethnopharmacological sources (e.g. manuscripts, folklore texts, ethnobotanical studies, ETHCSTWIN's subsequent phase will involve knowledge transfer and capacity building in AI, Machine Learning, and Data Mining methodologies, as well as advancing ethnopharmacological studies among the project's partners. This newly acquired knowledge and capabilities will contribute to developing of the ETHCSTWIN platform, which will serve as a resource for data collection, processing, and creating an extensive relational database comprising a vast dataset repository. The project will establish an Ecosystem Excellence Aggregator, presented as an open science community, that will host the ETHCSTWIN database and toolkit and will offer support for stakeholder training. ETHCSTWIN will provide a unique opportunity for IESP and its partners to develop the first European Ecosystem with IESP as the Regional Research Centre on Ethnopharmacology and Phytotherapy, connecting the Balkans, Mediterranean, and Central Europe. The successful implementation of this project will facilitate future collaborations with experts in the fields of Ethnopharmacology and Computer Science & will increase IESP’s research capabilities.

Keywords: ethnopharmacology,digital transformation of heis,transfer knowledge,innovation ecosystem,exchange of staff,capacity excellence
ENGRAMS IN TRAUMATIC MEMORY: FINDING NOVEL THERAPEUTIC AVENUES IN DEPRESSION AND PTSD. (PoMAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Despite 70% of people are going to experience a traumatic event throughout life, only 3.9% are going to develop post-traumatic stress disorder (PTSD). Curiously, people who develop PTSD also present a higher risk of developing Major Depressive Disorder (MDD). Thus, 50-70% of PTSD patients will live with a diagnostic of MDD, which in terms of prognosis means poor response to treatment and worse symptomatology. Despite the clinical relevance of this comorbidity, it remains unknown if there are shared molecular mechanisms. Impairments in fear memory and learning were related to PTSD and MDD, in association with atrophy and synaptic loss in the hippocampus (HPC). In turn, the HPC plays a crucial role in fear memory, encoding the contextual information related to the fearful stimulus. Thus, we propose that maladaptive fear memory due to hippocampal dysfunction can also contribute to MDD, explaining the high co-morbidity between PTSD and MDD. Importantly, preclinical research focus on fear memory have provided us with promising knowledge for potential PTSD therapeutics. For instance, the regulation of glucocorticoids in the “golden hours” after trauma to prevent memory consolidation, the use of beta-adrenergic blockers to disrupt consolidated memories, or different psychotherapeutic approaches to enhanced memory extinction. Recently, the advances with chemo- and optogenetic technics have allowed the identification and functional modulation of neurons involved in encoding a specific memory (engrams), thereby allowing a highly refined study of memory substrates. Despite these advances, the use of such approaches in genetic animal models for the study of psychiatric comorbidities is still poorly explored. We believe that this combination can bring new insights and methodological possibilities for the field. In parallel, increase our understanding about the basis of PTSD and MDD can provide new therapeutical targets with direct implications for human health.

Keywords: maladaptive memory,hippocampus
Oceanic hitchhikers: epizoic diatoms as health indicators of sea turtles (OCEANHITCH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway,Belgium,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-01
End date: 2027-01-31
Duration (months): 30.0
Total project cost (EUR): 283438.8
EU funding (EUR): 283438.8
Participants: 3
Project status: SIGNED

Diatoms, unicellular algae, grow on a wide range of submerged surfaces. However, some diatom species and even entire genera (Chelonicola, Poulinea, Tursiocola) are highly specialised and thrive exclusively on the surface of glabrous aquatic animals (sea turtles, sea snakes, cetaceans, manatees). These taxa tolerate frequent environmental changes related to the biology and lifestyle of their hosts but, in nature, cannot survive without them. We will use sea turtle biofilm samples to investigate whether this unique association makes epizoic diatoms suitable indicators of their host’s health. This proposition is based on our preliminary observations that in sea turtles, the relative abundance of epizoic diatoms is high (>35 %) on generally healthy individuals, but rarely exceeds 10 % in visibly debilitated animals. First, skin and carapace biofilm samples will be collected from 350 presumably healthy and 175 visibly debilitated sea turtles from three distant geographic regions (WP1). Second, the collected material will be used to determine diatom species composition based on molecular (metabarcoding) and morphological approaches (WP2). We will develop an automated diatom identification and counting method using deep learning technology to further simplify the morphology-based assessment of diatom community composition. Third, the relative abundance of specialist sea turtle diatoms will be assessed and tested for correlation with standard sea turtle health indices collected for every sampled animal (WP3). Diatom indices of sea turtle health will be designed should such correlation be found. Finally, we will test the newly developed tools in a zoo setting, where they will be used to gain insights into the overall health and wellbeing of captive sea turtles and other aquatic vertebrates (WP4). The proposed studies will develop novel, non-invasive, cost-efficient and straightforward diatom-based tools for sea turtle monitoring and the assessment of marine ecosystem health.

Keywords: automated taxonomic identification,bioindicator,diatom indices,epizoic diatoms,metabarcoding,nature conservation,sea turtles
Port solutions for efficient, effective and sustainable multimodality (MultiRELOAD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Germany,Austria,Switzerland,Hungary,Spain,Belgium,France,Netherlands
Call: More efficient and effective multimodal freight transport nodes to increase flexibility, service visibility and reduce the average cost of freight transport (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 8846055.14
EU funding (EUR): 7417813.13
Participants: 25
Project status: SIGNED

MultiRELOAD focusses on the specific role and challenges of inland ports as multimodal freight nodes in reaching Europe’s greenhouse gas (GHG) reduction target of at least 55 % by 2030, thereby shifting a substantial part of the 75% of inland freight carried today by road in the EU to inland waterways and rail, and by increasing operational efficiency, safety and reliability of existing infrastructures through digitalization. Inland Ports are key for multimodal transport chains, both continental and maritime transport. Without efficient nodes in the hinterland multimodal transport is not possible. However, the constraints and barriers are much higher in inland ports (space, urbanisation, demand, investments) than in seaports. MultiRELOAD enhances the collaboration between different freight nodes in Europe to jointly test innovations and create favorable market conditions for multimodal freight transport solutions. MultiRELOAD will demonstrate solutions in three Innovation Areas with specific aims by 2025 – mirroring measures of the EU’s Smart Mobility Strategy: A) Smart multimodal logistics: facilitate a shift from road to rail & IWT of 5%; B) Digital & Automated Multimodal Nodes and Corridors: increase operational efficiency by 20 % raise of handling capacity; C) Innovative business models: leading to an average cost reduction of freight transport by 10%. MultiRELOAD involves highly ambitious logistics hubs, including the multimodal node duisport (DE), Duisburg's highly ambitious port and the world’s largest and most advanced trimodal inland hub terminal, and the trimodal nodes Ports of Vienna (AT) and Basel (CH). The project is backed up by additional funding & financing for better integration of the freight transport nodes into overall logistic chains of about 450 Mio. EUR. MultiRELOAD involves a total of 22 partners comprising of highly innovative technology, logistics and service providers, leading European research institutions and well-connected networks.

Keywords: freight,multimodality,inland waterway transport,rail transport,inland ports
Rolling fund of pre-financed social energy shares makes local renewable energy accessible for all (Power Up Eeklo)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: European Social Innovation Competition
Action type: Recognition Prize
Countries involved: Belgium
Call: The European Social Innovation Competition 2023 (HORIZON-EIC-2023-EUSIC-PRIZES-04, 2023)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 2
Project status: SIGNED

The city of Eeklo in Belgium works closely with local citizen-energy cooperatives to ensure access to affordable, local, renewable energy for its citizens. Since 2000 several wind turbines were developed on public grounds of the city by the citizen-energy cooperatives Ecopower and Volterra. This way over 500 households (5% of total households) in Eeklo became member of the cooperatives in the last 20 years. The average profile of these households are highly educated middle class families. As a city we want that our local energy is available for every citizen, especially households in energy poverty as they could benefit even more of lower energy prices from the cooperative Ecopower (that has a suppliers permit in Flanders). But becoming member of the cooperative means becoming shareholder by investing €250 euro in the cooperative, a financial barrier which makes membership out of reach for a lot of families in energy poverty. The city of Eeklo and Ecopower are setting up social energy shares to overcome this financial barrier. The social shares are shares of the cooperative that are pre-financed by the city and that can by used by lower income households. The households pay the value of the share (€250) spread over 6 years via their monthly advance invoice (€3.5 montly). They are full members of the cooperative from the start. We work closely with social services to identify households with difficulties to pay their energy bill and help them transfer to the cooperative supplier if they are interested. This way we try to make affordable, local, renewable energy accessible for every inhabitant of the city, regardless of their household budget.

Keywords: cooperative citizen energy renewable rolling fund
Selection efficacy at intraspecific and interspecific scales: insights from haplo-diplontic plants (BryoFit)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1498110.0
EU funding (EUR): 1498110.0
Participants: 1
Project status: SIGNED

Natural selection is a pillar of evssNatural selection is a pillar of evolutionary biology: it tends to fix beneficial mutations and remove deleterious ones. But the factors that determine selection efficacy are yet poorly understood. A proposed factor is the interaction between mutations? dominance and ploidy level: recessivity should reduce selection efficacy in diploids but not in haploids. Methodological limits make this challenging to test in species with a diploid-dominant life cycle. Yet, a whole phylogenetic clade under-explored in genomics gathers all the attributes to tackle this question: Bryophytes. Their life cycle is characterized by alternating a long haploid phase (gametophyte) with a short diploid phase (sporophyte), both phases being macroscopic. It is ideal for shedding light on what drives selection efficacy within and between species; thus, improving our understanding of adaptation and speciation. 1 How ploidy affects the efficacy of adaptive and purifying selections within species? Using comparative genomics, I will empirically test i) if selection is more efficient for haploid-biased genes (i.e., expressed primarily in the gametophyte) than diploid-biased genes, and ii) if that difference is reinforced in species with a more complex sporophyte. 2 How ploidy affects the efficacy of selection against hybridization between species? With theoretical developments, I will quantify the extent to which the length of gametophytic and sporophytic phases influences the rate of accumulation of reproductive barriers against interspecies introgression. These predictions will be confronted with genomic estimates by developing a statistical inference method. 3 How efficient is selection in non-recombining genomes? I will take advantage of the Bryophytes? U/V sexual system to assess the extent to which selection efficacy is reduced on their sex chromosomes. I will also tackle an overlooked issue: are U/V sex chromosomes efficient barriers to introgression?