Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Young researcher network for security and resilience of critical cyber-physical systems (SecReSy4You)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus,Germany,Netherlands,Sweden,Spain,Italy,Austria,Estonia
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-02-01
End date: 2030-01-31
Duration (months): 48.0
Total project cost (EUR): 2929141.08
EU funding (EUR): 2929141.08
Participants: 18
Project status: SIGNED

Control systems are not only at the core of most engineering systems but also form the backbone of critical infrastructures, such as distribution systems for electricity and water, transportation networks, and mobile communications. The increasing network connectivity of control systems has highlighted the necessity for ensuring resilient and secure operation against cyber attacks, which have become increasingly sophisticated over the years and have often had severe repercussions. At the same time, by nature, control systems combine characteristics that render the provision of cybersecurity challenging. Existing security mechanisms typically ignore the cyber-physical nature of networked control systems and either focus on the cyber or physical domain exclusively. Such narrow viewpoints not only impair any proposed security mechanisms but also result in limited models for underlying systems and attacks. Academic contributions are typically distant from practical industry challenges, simply resulting in an isolated view on the IT security properties of confidentiality, integrity, or availability (CIA), without providing comprehensive security solutions. Adding insult to injury, proposed security mechanisms are rarely validated via suitable testbeds or experiments in the field. This DN intends to bridge the gap between theory and practice for secure and resilient cyber-physical systems by tackling the problem at its root. It brings together domain experts from control theory, computer science, and major industrial stakeholders to boost the security and resilience of control systems by outlining a sustainable program for training the next generation of innovators in this critical domain. It pursues a holistic approach that combines specialized training (in both academia and industry), while identifying challenging characteristics and security flaws in existing legacy systems, and pinpointing design requirements and solutions in future (networked) control systems.

Keywords: ot and it security,resilience,cyber physical systems,anomaly detection,coding,authentication,physical modeling
SECURITY HARMONIZED INNOVATION FOR ENHANCED LAW ENFORCEMENT CAPABILITIES IN DYNAMIC CROWD PROTECTION THROUGH PRE-COMMERCIAL PROCUREMENT (SHIELD PCP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Strengthened Security Research and Innovation
Action type: Pre-Commercial Procurement
Countries involved: France,Greece,Netherlands,Poland,Spain,Slovakia,Italy
Call: Demand-led innovation through public procurement (HORIZON-CL3-2024-SSRI-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 5249811.26
EU funding (EUR): 5249811.25
Participants: 14
Project status: SIGNED

The SHIELD PCP initiative aims to drive innovation by empowering buyers to actively influence the development of cost-effective solutions tailored to their unique requirements. The overarching aim is to equip security stakeholders with cutting-edge technology procured through innovative processes, offering solutions that enable seamless coordination and cooperation among all stakeholders, especially law enforcement agencies (LEAs). Building on the achievements of its predecessor, SHIEL4CROWD, the SHIELD PCP project adopts a top-down approach. This method consolidates widely agreed-upon scenarios to address critical security challenges, providing a detailed identification of innovation needs at both the process and technology levels. This top-down approach enabled the alignment of stakeholders, from security forces to public authorities, ensuring innovative solutions meet shared needs for public space protection. SHIELD4CROWD also developed a roadmap of innovations addressing operational and technical challenges while considering regulatory and economic factors. SHIELD PCP continues this work to enhance collaboration and improve public space security. The project follows a phased Pre-Commercial Procurement (PCP) process, which includes: Preparatory Phase: Finalizing the tendering documentation developed during SHIEL4CROWD; Phase 1: Solution Design ;Phase 2: Prototype Development; and Phase 3: Operational Validation, conducted across three pilot sites in France, Spain, and Slovakia. A consortium of 10 partners from 6 EU countries, including 3 Ministries of Interior and 1 public transport operators as Public Buyers and 1 end-user, is collaborating on this project. Many other end-users will also be involved through the User Observatory Group (UOG).

Keywords: coordination and cooperation between security stakeholders
Field operational handheld Raman spectrometer and confocal Raman microscope duo for trace detection of illegal substances (FORSTrace)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

In 2021, the EU’s illegal drug market was estimated to have a minimum retail value of at least €31 billion representing a major income source for organised crime groups. A key feature of the illegal drug market is its intersection with (and significant impact on) other crime areas, such as trafficking of firearms and money laundering. This illegal, parallel economy is not only impacting the legal economic sectors; it is also taking a grim toll on society, as it directly contributes to increased corruption, as well as wider criminal activity and terrorism. Police and customs officers, airport border controls and law enforcement agencies in general are major checkpoints in the global fight against illegal drug trade and, as such, they are in urgent need of more effective, reliable, and affordable solutions to this grave problem. Raman spectroscopy is a gold standard when it comes to detection and tracking of illicit substances/trace elements. However, today’s Raman devices are still too expensive and bulky, which limits technology development in a broader range of applications including consumer cases. It is our ambition to overcome this threshold and democratise the power of high-end Raman spectroscopy for the benefit of mankind. Our response to this growing need is the development of a unique miniRaman (mR) system, combining the power of our mR spectrometer, integrated in a mR microscope, and with a fully automated, artificial intelligence (AI)-enabled motorised 3D stage. The purpose of this automated 3D stage is to autonomously scan the sample for potential areas of interest, which are then analysed and cross-compared with the several thousand Raman spectra held in the proprietary software library. Furthermore, our mR system uses patented technology that incorporates a reference channel within the instrument, allowing for the use of less expensive lasers, unprecedented miniaturization and other unfair advantages compared to existing handheld Raman devices.

Keywords: raman spectroscopy microscopy,spectra,reference channel,illegal substances,trace elements,customs,border control,forensics
Development of a universally applicable, commercially-ready NGPod system (NGPod)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2299000.0
EU funding (EUR): 2299000.0
Participants: 1
Project status: SIGNED

NGPod Global is a UK based med-tech company dedicated to improving the safety and effectiveness of nasogastric (NG) feeding. The company has invented and developed a unique fibre-optic based solution to the problem of confirming the position of NG feeding tubes. A misplaced tube can result in serious injury or death, so position confirmation is essential. Existing practice is unreliable, time-consuming and inaccurate, resulting in delayed delivery of vital nutrition and medication, slower recovery, anxiety for patients and practitioners and unacceptable risks of injury or death. The company has developed an initial system that has been fully adopted by several hospitals. The response has been extremely positive. Early adopters have demonstrated 77% reduction in the use of X-rays for tube confirmation and a net cost saving of over £40 per patient per day. Hence, a very real and urgent need for the NGPod concept has been demonstrated. NGPod must now use the window of opportunity presented by this positive response, along with the UK Government’s drive to apply innovations across the NHS that both improve patient outcomes and deliver added value, and a growing international awareness of dangers associated with NG feeding. It needs to act urgently to develop the system for scale-up and to optimise product-market-fit, by developing technical features which have been identified through working with early adopters as essential for accessing the wider market and placing NGPod as the international “go-to” system for NG safety. The technical developments will deliver applicability of the NGPod solution to all age-groups and conditions, improved usability and sensitivity, verifiable digital records and connectivity to healthcare data systems. Hence EIC assistance and funding is an essential bridge to rapidly growing a business that provides many benefits to society, creates high-value employment and delivers a life-saving solution to an international market.

Keywords: nasogastic feeding,fibre optic based solution to the problem of confirming position of feeding tubes
Contested Knowledges in and through Asylum Litigation (ASYKNOW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Migration, and particularly the question of asylum, has become one of the most pressing and polarizing issues of our time. Scholars have highlighted how the high level of contestation and politicization in this area has increased the demand for a wide range of expert knowledge. At the same time, this situation has thrown expert knowledge into a terrain of conflict. Consequently, the notion that expert knowledge provides a proper foundation for legal decision-making regarding asylum is under pressure. ASYKNOW will develop new conceptual tools for understanding the role of expert knowledge in asylum governance by investigating the ways in which knowledge about asylum seekers and migration is constituted and contested through asylum litigation. The project moves beyond traditional approaches to expert knowledge in migration scholarship, which has largely examined the content of decisions and adopted a one-directional approach to expert knowledge as an instrumental and/or symbolic tool of states’ domination. Instead, a focus on asylum litigation allows us to examine 1) how knowledge claims attain meaning and authority through the relational dynamics between differently situated actors, 2) how legal thresholds and tactics evolve as they pertain to the use of expert knowledge, and 3) how types of knowledges and knowledge claims facilitate or challenge states’ ability to exercise power over bodies and spaces. ASYKNOW brings together theoretical concepts, methodological approaches, and findings from geography, anthropology, law, and Science and Technology Studies (STS) – that have hitherto remained fairly separate with regard to the study of migration – into a novel and productive dialogue. Methodologically, the project adopts an ambitious in-depth comparative research design that innovatively combines an ethnography of legal processes with legal archaeology. Empirically, the research will focus on litigation of asylum-related cases in Norway, Sweden, Denmark, and Germany.

Keywords: expert knowledge,asylum litigation,law,ethnography,legal archeology,geography,anthropology,science and technology studies
Deciphering the COMPASS that guides cancer (COMPASS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Epigenetic features are commonly dysregulated in cancer and one of the surprising findings from the sequencing of cancer genomes is the high rate of alterations in many epigenetic regulators. KMT2D/MLL4, KMT2C/MLL3 and KDM6A/UTX are among the most frequently mutated genes in a wide range of cancers and in normal aged epithelial cells. Interestingly, these three genes are components of the same complex, COMPASS-like complex that regulate enhancer activity and regulate gene expression in a lineage specific manner. The deletion of members of the COMPASS-like complex has been associated with altered differentiation, aging and tumorigenesis. However, the precise mechanisms by which mutations in these genes impact cell states during tissue homeostasis, tumour initiation, tumour heterogeneity and metastasis, remain poorly understood. To address these important questions, we will use multidisciplinary approaches that will combine in vivo single cell lineage tracing, single-cell genomics, epigenomics and transcriptomics, in vivo CRISPR-based gene editing, together with genetic and pharmacologic perturbations, to define in a comprehensive and integrated manner the impact of Kmt2d, Kmt2c and Kdm6a deletion on cell state dynamics during homeostasis, regeneration, early steps of tumour initiation, tumour heterogeneity and metastasis in skin squamous cell carcinoma and bladder cancer. Moreover, we will perform genome wide CRISPR-Cas9 screen to identify the synthetically lethal genes in KMT2D, KMT2C and KDM6A mutated cancer cells to uncover new tumour vulnerabilities that can be pharmacologically targeted.

Keywords: stem cell dynamics,epigenetic regulation,histone methyl transferases,compass like complex,clonal evolution,tissue regeneration,tumour initiation,tumour heterogeneity,metastasis,synthetic lethality,crispr screen,
Dealing with Change: Women's Politics and Postwar Reconstruction in Romania Placed in Transnational Perspective, 1944–1948 (RECKON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

RECKON will analyze how women politicians and grassroots activists shaped the postwar remaking of the key political fields of public health, labor, foreign affairs and culture in post-World War II Central and Eastern Europe, with a focus on Romania between 1944 and 1948. In Romania and across Central and Eastern Europe, the period between the end of World War II and the start of the Cold War was one of extraordinary experimentation in women’s politics, with significant effects on postwar reconstruction. The four years between Romania’s 1944 armistice with the Allies and the 1948 establishment of the Popular Republic of Romania saw a first cohort of communist and left-leaning women politicians in office in the country (including, in 1946–1947, 17 MPs and two ministers). It saw tens of thousands of women mobilized for social work and political agitation. Most research on reconstruction stresses postwar state expansion in Western Europe and emphasizes postwar disarray in Eastern Europe. Women’s historians have focused on women in Eastern European politics in the less ideologically eclectic post-1948 period. RECKON aims to show that the postwar process of state reinvention in Eastern Europe resembled developments in Western Europe yet was region-specific through the importance women had as reconstruction planners and envisioned reconstruction beneficiaries, in a context marked by upheaval and flare-ups of violence. Merging approaches from gender history and transnational history, RECKON will advance understanding of the role of women and gender in the forging of new social contracts in Europe. It will enable the recruited researcher to enhance her expertise and professional capacities through career development and mentorship programs accessible through her host institution. RECKON’s deliverables are two articles, one edited volume proposal, two open access syllabi, one podcast script and regular blogposts.

Keywords: central and eastern europe,postwar reconstruction,women s organizations,grassroots activism,left wing women s politics
Study on the Biomechanical Mechanism of Patient-Orthosis Interaction Based on Subject-Specific Patient-Orthosis Coupling Musculoskeletal Model (KOA-Orthosis)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: CLOSED

Knee osteoarthritis (KOA) is a prevalent, chronic, degenerative, and multifactorial disease associated with pain, stiffness, and physical disability, and it is a significant public health problem in the world. Abnormal load distribution between knee medial and lateral compartments has been designated as the main biomechanical factor for the initiation and progression of KOA. Accurate quantification of internal knee contact force during daily living activities is significant for understanding the biomechanical mechanism of patient-orthosis interaction and improving the treatment with knee orthotics. During the passing years, some subject-specific musculoskeletal models have been proposed to improve the prediction accuracy of internal knee contact force. However, approximations such as linear scaling, point contact assumptions, absence of ligaments, inaccurate muscle models, and absence of proper knee models are present in most models. Additionally, new human-orthosis coupling models have been proposed during the past years. However, disadvantages such as a relatively simple human model, non-patient model, and rigid contact between human and orthosis, remain. Therefore, the current musculoskeletal models and human-orthosis coupling models are not suitable for deeply studying the biomechanical mechanism of patient-orthosis interaction. The goal of the research will focus on (1) developing a subject-specific patient-orthosis coupling musculoskeletal model considering subject-specific geometric models of bones, cartilages and meniscus, knee ligaments, muscle modelling, natural contact, and patient’s disease progression; (2) analyzing the biomechanical relationship between the applied orthopedic moment and internal contact forces of knee medial and lateral compartments, and understanding the interaction between the knee orthosis and KOA patients; (3) simulation-based design and evaluation of a prototype knee orthosis based on the developed interaction models.

Keywords: musculoskeletal model,biomechanics,knee osteoarthritis,knee orthotics,patient orthosis interaction
Innovative Photoactivated Ruthenium Chemotherapy to treat eye cancer (PACT4EYE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,France,Italy
Call: EIC Transition Open 2023 (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 2499998.75
EU funding (EUR): 2499998.75
Participants: 4
Project status: SIGNED

Uveal melanoma (UM) is a rare tumor of the eye; its current treatment leads to lower quality-of-life for the patients (sight loss), 50% of whom eventually die from metastases to the liver. The PACT4EYE project aims at the first clinical development of a new technique called photoactivated chemotherapy (PACT) for the treatment of UM. It makes use of a new, patented ruthenium-containing prodrug (Ru-MTI) that must be activated by green or red light to become toxic. PACT uses laser light irradiation at the tumor site to activate the prodrug locally and destroy the tumor with low side effects for the patient. Its innovative mode of activation, based on a dioxygen-independent bond cleavage photoreaction, makes PACT treatment with Ru-MTI fundamentally different from state-of-the-art UM treatment that rely on O2 activation. Unlike them, Ru-MTI can still be activated in hypoxic tumor tissues, which are usually more resistant to existing treatment and more threatening for the patients. The consortium will screen and optimize the tumor response and systemic toxicity of PACT treatment with Ru-MTI in primary UM eye tumors and their liver metastases, using patient-derived tumor models engrafted in zebrafish embryos (ZF) and mice. Once the most responsive tumors are identified in ZF, the treatment will be optimised in sub-cutaneous mice models and further validated in an "orthotopic" mouse PDX model (for example, a liver metastasis in the liver), which represents one of the most predictive pre-clinical tumor models available to date. These results will allow our commercial partner to define a "minimum viable product" for PACT treatment of UM tumors with Ru- MTI, and to develop a business plan and a communication plan towards the first clinical application of ruthenium-based PACT. The project will gather all pre-clinical data necessary to convince venture capital and/or funding agencies to fund clinical phase I studies and further product development after the project.

Keywords: cancer,microtubule,inhibitor,photopharmacology,hypoxic tumour,metastases