Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Single-Molecule Technology for Resolving Chaperone Action in Neurodegenerative Diseases (MicroSPARK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

A range of debilitating neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, arise from the formation of amyloidogenic protein aggregates. Molecular chaperones can counteract aggregate formation, but their molecular action mechanisms remain poorly understood. This is chiefly due to the fundamental challenge of resolving heterogeneous and dynamic aggregating protein species in the presence of chaperones. In order to address this challenge and to advance our knowledge of chaperone action, I propose establishing µSPARK, a novel technology that will allow, for the first time, the unravelling of the detailed microscopic mechanisms by which chaperones target and disassemble amyloidogenic protein species in heterogeneous mixtures at the single-molecule level. These new insights will become possible through the first-time combination and seamless integration of two advanced technologies: (i) Miniaturized fluidic sorting devices and (ii) single-molecule fluorescence spectroscopy combined with three-colour coincidence detection. This will enable high-throughput single-particle interrogation of individual chaperone–aggregate complexes providing fundamentally new means for understanding key aspects of chaperone function. To demonstrate the new possibilities, µSPARK will be exploited to unravel the action mechanisms of heat-shock proteins in curtailing amyloid-β peptide and α-synuclein aggregation. This will provide new insights into proteostatic regulatory mechanisms in Alzheimer’s and Parkinson’s disease. The µSPARK technology will then be exploited to dissect—with high throughput and single-particle resolution—the molecular action mechanisms of small-molecule modulators that promote the inhibitory function of chaperones on protein aggregation. This will allow identifying new strategies to ameliorate aggregate toxicity and will pave the way for µSPARK to become a novel screening tool for drug development.

Keywords: single molecule fluorescence,microfluidics,molecular chaperones,protein aggregation,drug discovery
New solution for fully automated analysis and reporting of routine musculoskeletal X-rays (AutoRay)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-05-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Routine radiology services are facing a huge problem delivering analysis of the very large number of X-ray images shortly after acquisition – leading to patients sometimes waiting for weeks for the results. The current number of radiologists is insufficient to efficiently analyse and deliver the medical report shortly, causing unnecessary stress for patients and potential delay in diagnosis and treatment. Radiobotics is developing a machine learning-based software that automatically analyses routine X-rays of the musculoskeletal system and generates the respective medical report. Although the recent advances in machine learning have accelerated the development of tools for medical imaging analysis, the solutions available are only semi-automatic and focused on other more acute and specific diagnoses. Radiobotics automatic software will decrease time use and improve diagnostic quality, greatly benefiting: 1) radiologists/physicians by lowering the amount of images queued up for analysis and increase the diagnostic volume that radiologists can deliver, while providing a more objective analysis; 2) hospitals/clinics/radiology centres by optimizing their workflow, saving costs and offering higher quality services to patients; and 3) patients by having access to a faster and accurate diagnosis and consequently early treatments. AutoRay project will enable maturing our technology to a market-ready software and also to implement an effective business and communication strategy to build market awareness, and customer trust. We are supported by clinical development partners in Denmark and UK, and our team has the right combination of expertise in biomedical engineering, machine learning, business development and commercialization to perform this project and fulfil all the needs and requests of end-users and customers, eventually benefiting the society as whole.

Keywords: deep learning,automating radiology,data driven health technology
Novel electric turbines to power the VTOL drone & aircraft revolution (Apollo)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For decades, vertical take-off and landing aircrafts (VTOL) have seen their use limited to special-purpose & military applications. By 2017, companies like Lilium Aviation and others started showcasing prototypes of electric “flying cars”. The key problem with these prototypes is that they require an efficient & reliable electric propulsion technology to be able to lift off their payload of 1-2 people. This propulsion technology must also support transition from VTOL to linear flight, otherwise its energy consumption will not allow any useful applications. European Sustainable Propulsion brings to the market the first solution able to support the industrialization of VTOL development—an electric turbine technology with both static thrust for VTOL & dynamic thrust for linear flight. Apollo electric turbines are 2-4x more efficient than other electric ducted fans, support tilt-free transition from VTOL to linear flight, are compact and are designed to enable scalable distributed electric propulsion. Our unique innovation enables design of novel, much safer VTOL drones for operation in congested urban areas & on dangerous industrial sites, allowing us to commercialize it to both to the current nascent market of passenger VTOL manufacturers, as well as to the upcoming heavy-duty VTOL market. Our analysis shows the target markets for commercialization of Apollo of €13.75bn+ for passenger VTOLs and €690bn+ for heavy-duty drones in verticals such as oil & gas, construction, security & others. In 2017 we were featured in Wired as a refreshingly realistic technology among other VTOL & drone-enabling technologies. Athena, the 1st generation of Apollo family turbines, are now under testing in FR, US & CA. Japanese Fire & Disaster Management Agency has just signed the purchase order for it. By selling Apollo electric turbines to other VTOL drone manufacturers (short-term) & by building or own heavy-duty drones (long-term) we aim at €30m by 2022.

Keywords: vtol,drone,turbine,electric
Advanced composites for lightweighting land transport structures using pultrusion process (MOTIONPult)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Automotive and rail industry aim at decreasing the weight of their vehicles to comply with new legislation and/or to reduce their operational energy costs. The best alternative due to their features and price is to implement carbon composites materials. Yet they are expensive (20-30 €/kg) and their manufacturing does not meet automotive production rate. Hence, we have developed MOTIONPult which is a combined system of Hybrid Composite of glass and carbon fibres & Continuous Pultrusion process that will offer a material with a carbon fibre volume of 15-25%, at a price of 5-10 €/kg and a 70-75% lighter than steel. MOTIONPult will be the first fully continuous Pultrusion process to supply materials to automotive manufacturers. Fiber Profil S.L. is a successful pultrusion company founded in 1994, with a staff of more than 100 years of accumulated experience and with more than 220 clients in 8 countries within 5 continents, such as France, U.S.A, Mexico or Saudi Arabia. With MOTIONPult project we aim to disrupt into the lightweight market by covering end users` needs (cost, production rates and aesthetics) not satisfied by current alternatives which will allow us to reach a turnover of € 12.1 Mill and increase our staff by 12 people by 2024. Yet, to achieve the commercialisation stage we still need to widen our product portfolio and have our profiles tested by end user´s such as Irizar and Talgo that have supported this proposal with attached letters, and we must plan the dissemination and exploitation activities. Thus, we have decided to continue with MOTIONPult for what we need an additional investment of € 1.6 Mill, that will give us a ROI of 4.6 by 2024. Therefore, we consider essential to perform a detailed feasibility study to continue with our project and decided to ask for funding through this SME instrument.

Keywords: composites,pultrusion,automobile,rail
Combustion for Low Emission Applications of Natural Gas (CLEAN-Gas)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Italy,Italy,Belgium,Belgium,France,France
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EJD) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3832293.6
EU funding (EUR): 3832293.6
Participants: 8
Project status: CLOSED

Natural Gas (NG) will be one of the key parameters of the EU energy policy for the next decades. EU gas imports are expected to reach over 80% of total consumption by 2030. Thus, the EU is investing heavily in natural gas equipment. Natural gas combustion has two side effects: the production of greenhouse gases and the emission of pollutants. Conventional techniques used to reduce these emissions are post-combustion treatments. Another solution is to act directly on the combustion process, limiting the pollutant formation, while maximizing the efficiency. New processes are using this strategy: regenerative burners, flameless combustion, combustion of highly diluted mixtures or oxy-combustion. These technologies are still poorly understood. It is therefore important to develop studies on these new combustion processes, whose development needs real technological breakthroughs. Reaching these goals requires to investigate the involved phenomena and detailed experiments and modelling of the kinetics and fluidynamics of the combustion processes are of paramount importance. The CLEAN-Gas EJD Programme proposes high-level training for doctoral candidates with the following main objectives: – developing and sharing innovative experimental diagnostic techniques; – creating and validating detailed chemistry mechanisms of the combustion process; – proposing new turbulent combustion models; – enhancing high performance computing; – encouraging team work and project oriented approach; – proposing innovative applications, processes and technologies for NG combustion; – participating in the European energy policy. All students will receive a high-level training in the aforementioned domains through their PhD work with a multi-disciplinary vision and a key training for developing professional skills. The PhD candidates will be able to understand and respond to most of the key issues of the natural gas use in the European context.

Keywords: natural gas,combustion,chemical kinetics,emissions
Confronting Obesity: Co-creating policy with youth (CO-CREATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Research and Innovation actions
Countries involved: Australia,South Africa,Norway,Belgium,Norway,Poland,Netherlands,United States,Portugal,United Kingdom
Call: How to tackle the childhood obesity epidemic? (H2020-SFS-2017-2, 2017)
Start date: 2018-05-01
End date: 2023-10-31
Duration (months): 66.0
Total project cost (EUR): 9757943.75
EU funding (EUR): 9678653.75
Participants: 14
Project status: SIGNED

CO-CREATE aims to reduce childhood obesity and its co-morbidities by working with adolescents, to create, inform and disseminate obesity-preventive evidence-based policies. The project applies a systems approach to provide a better understanding of how factors associated with obesity interact at various levels. The project focus on adolescence as the specific target group, a crucial age with increasing autonomy and the next generation of adults, parents and policymakers, and thus important agents for change. CO-CREATE involve and empower adolescents and youth organizations to foster a participatory process of identifying and formulating relevant policies, deliberating such options with other private and public actors, promoting relevant policy agenda and tools and strategies for implementation. CO-CREATE strengthen interdisciplinary research and have an inclusive multi-actor approach with involvement of academics, policy makers, civil society, relevant industry and market actors to ensure long-lasting implementation of the results. The project reflects and builds on a number of existing initiatives and platforms, including the extensive research activity from consortium members. The project has a strong gender profile and consider the relevance of geographic, socio-economic, behaviour and cultural factors. CO-CREATE engages international partners from different policy-contexts in Europe, Australia, South Africa and the US. Applying large-scale datasets, policy monitoring tools, novel analytical approaches and youth involvement will provide new efficient strategies, tools and programmes for promoting sustainable and healthy dietary behaviours and lifestyles. The generated knowledge and innovative tools for assessing actual policy implementation, strategies for empowering adolescents; and strategies for identifying, implementing and monitoring relevant policy programmes are applicable to stakeholders involved in the European efforts to tackle childhood obesity.
TWO-Dimensional nanomaterial-based metasurfaces for enhanced Plasmonic Sensing (TWODPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-15
End date: 2020-06-14
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

In the past decade, biosensors have provided an effective way for the physical and chemical science to improve the quality of the life in the modern society. The biosensors are usually based on systems that can detect electronic or optical signals in terms of the concentrations of biological molecules. Thus, it allows the monitoring of molecular interactions from the signal change. Useful applications so far include DNA analysis, glucose concentration test in human blood, sensing of toxins in the water, food and atmosphere. Current challenges for the biosensors are to improve their detection sensitivity and efficiency while with reduced size and operation cost. My research aims to achieve simple, fast and sensitive detection through label-free biosensing technology. For this aim, I will develop a novel plasmonic sensor based on optimized 2D nanostructures with magneto-optic materials for achieving ultra-high sensitivity for the hard-to-identify small biomolecules and explore new physics on the magneto-plasmonic effects generated by the coupling between the 2D nanomaterials and gold/magnetic materials metasurfaces. Miniaturization for commercially portable products embedding those highly sensitive nanostructures will be studied. The proposed research will significantly improve my knowledge in exploiting the optical/magnetic properties of novel plasmonic nanomaterials for enhanced light matter interactions. This project will play a pivotal role for my personal development as an independent researcher and provide me with the unique opportunity to work with experts in the field of materials, electromagnetics and sensing. I will benefit from ideas and inputs from renowned researchers from various scientific disciplines to compliment my background. Moreover, I aim to deliver the related research works though a series of seminars and lectures to present the importance and relevance of utilizing novel nanostructures for sensor development.

Keywords: plasmonics,nanophotonics,magneto plasmonics,optical sensors,2d materials,metasurfaces
Nonequilibrium Quantum Transport, Probes and Simulations (NQTPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Nonequilibrium Quantum Transport, Probes and Simulations is an ambitious research proposal aimed at designing both theoretical methods and practical schemes to describe and control nonequilibrium many-body quantum systems. With a combination open-quantum-systems, tensor networks and non-equilibrium Green’s functions NQTPS will develop methods to model nonequilibrium quantum systems with applications to quantum transport, weakly disturbing probes and Simulations. Specifically we aim to (1) Control transport between many-body systems designing small quantum rectifiers that operate at their interface. The rectifier is an asymmetrical and non-linear structure that breaks reciprocity. This novel development will be done beyond the main-stream phenomenological approach to dissipative systems which fails to give correct results specially in the presence of structured baths. (2) Extend scalable Matrix-Product-State techniques to model 1-D many-body open systems beyond the local Lindblad approach. Once a method capable of describing open-many-body-systems is stablished we will use it to characterize emergent transport (ballistic, diffusive, anomalous, insulating). (3) Design weak-coupling schemes to small probes for measuring fine features of complex quantum systems. We will propose probing of spacial and time correlations while leaving the many-body system almost unperturbed. (4) Model the dynamics of two-dimensional driven dissipative systems, focussing on adiabatic evolution subject to external noise. These models describe the fundamental structure on which companies are investing on for prototype quantum simulators and computers. We aim to address driven dissipative phase transitions and analyze their impact for adiabatic quantum simulation and quantum annealers. We will develop a tensor-network-oriented method for addressing the many-body case merging Tree-tensor-networks with the time dependent-variational-principle.

Keywords: open quantum systems,nonequilibrium many body physics,tensor networks
HIGee to Furanic-based jet Fuel technologY (HIGFLY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Germany,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Developing the next generation of renewable energy technologies (H2020-LC-SC3-2020-RES-RIA, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3994322.5
EU funding (EUR): 3994322.5
Participants: 9
Project status: SIGNED

HIGFLY will develop the next generation of technologies for the production of advanced bio jet fuels from abundant and sustainable biomass feedstocks. In a nutshell, HIGFLY: 1. Utilises abundant and sustainable feedstocks (e.g. second-generation biomass and macroalgae), focusing on feedstock flexibility and synergies across the bioenergy sector. 2. Develops innovative, highly-efficient and scalable reactor and separation technologies to produce advanced bio jet fuels in a resource, energy and cost-effective manner. 3. Develops new and robust catalytic materials and sustainable solvents for the renewable energy sector. 4. Advances the knowledge of its innovative technologies by evaluation of the entire value chain (from feedstock(s) to bio jet fuel) to demonstrate the environmental, social and techno-economic performance of HIGFLY technologies and the prospect of regulatory compliance of HIGFLY’s bio jet fuel. HIGFLY will develop and demonstrate in a step-wise approach and under industrially relevant conditions (at TRL3-4) innovative and highly efficient conversion technologies and integrative approaches to valorise abundant and sustainable feedstocks in a resource-, energy- and cost-effective manner. This has the unique potential to increase the total share of advanced biofuels in the EU jet fuel market. In this way, HIGFLY addresses EU priorities for decarbonizing the transport sector through the key actions of the EU SET Plan, specifically: i) by sustaining technological leadership through development of highly performant renewable technologies and their integration in the EU energy system; ii) by reducing the cost of key technologies through maximizing resource and energy efficiency; and iii) by strengthening market uptake through intensive early-stage cooperation between key end-users, policy advisors and technology developers. The HIGFLY consortium combines experts along the entire value chain, from research to end users, to accelerate market uptake.

Keywords: novel reactors,solvents,membrane separation,highgee reactors,oxygenates