Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engine Mount System for Ultra High Pass Engine (EMS UHPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,Germany,Italy,Switzerland,France,United States
Call: Engine Mounting System (EMS) for Ground Test Demo (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-03-15
End date: 2022-12-14
Duration (months): 81.0
Total project cost (EUR): 3767511.13
EU funding (EUR): 1449144.5
Participants: 8
Project status: SIGNED

Our consortium is applying for the Engine Mounts System (EMS) of the Ultra High Propulsive Efficiency. Our 3 objectives are: 1. Assist the Engine Manufacturer & the Airframer in the evaluation & selection of the most promising & suitable Engine Mounts System (EMS) configuration. Criteria for evaluation: weight, cost, dynamic performance, certification, impact on engine & aircraft assembly. 2. Design, build, & test the selected concept for the Ground Test (GT) that is planned to validate study predictions & performances. Our intent is to develop solutions & technologies to minimize weight, reduce manufacturing process complexity, improve system dynamic performance, increase reliability, & provide continuous monitoring of system health & usage & measure in-flight EMS conditions & loads. The plan includes new solutions & technologies with a min. TRL 4 at CDR in order to advance to TRL 5, 6 at GT incl. EMS overall configuration validation & component optimization. 3. To develop & insert new solutions for ground test with lower TRL’s than 4 at CDR as parallel activities. These lower TRL solutions selected on their potential to provide a significant leap in the performance, manufacturing, & assembly. Our consortium consists of 1. international company with global reach & renown experience in the EMS industry, LORD Corp 2. a German SME, excelling in manufacturing of aerospace structures, HEGGEMANN 3. an Italian consulting SME in the field of structural mechanics, Vicoter 4. an Italian University, one of the leading science & technology universities in Europe, Politecnico di Milano This consortium set up a Work Plan starting in 3Q 2015 for a duration of 72 months, which is divided into 7 Work Packages, : • WP1: Management & reporting • WP2: Concept Studies & EMS Specification definition • WP3: GT Design & Development • WP4: GT Manufacturing & Delivery • WP5: GT Qualification & Testing • WP6: Support for Engine GT • WP7: Innovation & new Technologies development

Keywords: engine mounts,engine
Uncovering the role of cis genetic elements in antigenic variation of Plasmodium falciparum using the CRISPR-Cas9 genome editing technology (REACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2020-02-28
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Malaria is an infectious human disease caused by parasitic protozoans of the Plasmodium type. P. falciparum causes the most lethal form with about 400.000 deaths annually. Pathogenesis involves expression of clonally variant molecules encoded by multi gene families at the surface of the infected host cells (erythrocyte). The most important virulence factor is called PfEMP1, which undergoes antigenic variation and is encoded by 60 var gene members. Despite the major scientific efforts, the molecular mechanisms orchestrating antigenic variation are still elusive. The reason is the lack of tools to perform genome editing in the natural epigenetic context, which is crucial in this important immune escape process. We aim to investigate antigenic variation of P. falciparum, by means of the recently developed CRISPR-Cas9 tool. This genome editing technology allows the in situ genetic manipulation of var gene regulatory elements in a native chromatin context. Virtually, any locus can be targeted by a RNA guide to insert, exchange or delete specific DNA regions including generation of point mutations without introducing a selective marker. Alternatively, we will use a dead Cas9 version (dCas9), which consist on the targeting of the desired locus by an inactive Cas9. This dCas9 can be fused to protein tags or effectors. We will use these techniques to i) delete cis-regulatory elements of var genes, ii) to identify factors associated to cis-regulatory elements by Cas9 targeted immunoprecipitations and iii) to engineer a tool to perform activation/silencing of specific var genes by fusing the dCas9 with epigenetic effector molecules (silencing and activators). This project will combine state-of-the-art techniques in genome editing to study malaria parasite virulence and provide reliable, accurate and focused data about the implication of epigenetics in the process of antigenic variation. The new tools developed in this project will be highly relevant for other human pathogens.

Keywords: crispr cas9,epigenetics,plasmodium falciparum,malaria,antigenic variation,monoallelic expression,var gene,pfemp1
An experimental and bioinformatic toolbox for functional epigenomics and its application to epigenetically making and breaking a cancer cell (EpigenomeProgramming)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Austria
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-12-01
End date: 2021-11-30
Duration (months): 60.0
Total project cost (EUR): 1281205.0
EU funding (EUR): 1281205.0
Participants: 1
Project status: CLOSED

Epigenetic alterations can be detected in all cancers and in essentially every patient. Despite their prevalence, the concrete functional roles of these alterations are not well understood, for two reasons: First, cancer samples tend to carry many correlated epigenetic alterations, making it difficult to statistically distinguish relevant driver events from those that co-occur for other reasons. Second, we lack tools for targeted epigenome editing that could be used to validate biological function in perturbation and rescue experiments. The proposed project strives to overcome these limitations through experimental and bioinformatic methods development, with the ambition of making and breaking cancer cells in vitro by introducing defined sets of epigenetic alterations. We will focus on leukemia as our “model cancer” (given its low mutation rate, frequent defects in epigenetic regulators, and availability of excellent functional assays), but the concepts and methods are general. In Aim 1, we will generate epigenome profiles for a human knockout cell collection comprising 100 epigenetic regulators and use the data to functionally annotate thousands of epigenetic alterations observed in large cancer datasets. In Aim 2, we will develop an experimental toolbox for epigenome programming using epigenetic drugs, CRISPR-assisted recruitment of epigenetic modifiers for locus-specific editing, and cell-derived guide RNA libraries for epigenome copying. Finally, in Aim 3 we will explore epigenome programming (methods from Aim 2) of candidate driver events (predictions from Aim 1) with the ultimate goal of converting cancer cells into non-cancer cells and vice versa. In summary, this project will establish a broadly applicable methodology and toolbox for dissecting the functional roles of epigenetic alterations in cancer. Moreover, successful creation of a cancer that is driven purely by epigenetic alterations could challenge our understanding of cancer as a genetic disease.

Keywords: epigenomics,dna methylation,histone modifications
The use of computational techniques to Improve compliance to reminders within smart environments (REMIND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,Ireland,Italy,Argentina,Italy,Sweden,Sweden,Colombia,Korea, Republic of,Norway,Netherlands,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-10-31
Duration (months): 70.0
Total project cost (EUR): 1084500.0
EU funding (EUR): 976500.0
Participants: 17
Project status: CLOSED

The aim of this Project is to create an International and Intersectoral network to facilitate the exchange of staff to progress developments in reminding technologies for persons with dementia which can be deployed in smart environments. The focus will be on developing staff and partner skills in the areas of user centered design and behavioral science coupled with improved computational techniques which in turn will offer more appropriate and efficacious reminding solutions. This will be further supported through research involving user centric studies into the use of reminding technologies and the theory of behaviour change to improve compliance of usage. A program of work has been established to maximise the transfer of knowledge between the different sectors offering a range of development and training opportunities for staff. Industrial staff will benefit from bi-lateral exchanges from the technical domains of context aware reminding technologies, soft computing, aware intelligent systems, pervasive computing and the psychological domain of behaviour change. The academic beneficiaries will benefit from gaining experience in the development of industrial standard software conforming to ISO and medical standards, engagement with stakeholders through a user centred design process and working with organisations delivering care to the elderly and persons with dementia. The consortium is comprised of an International network of beneficiaries and partners, all of which are committed to progressing the notion of reminding technologies within smart environments.

Keywords: reminding,cognitive prosthetics,connected health,behavioral science,user centered design
Safety tolerance zone calculation and interventions for driver-vehicle-environment interactions under challenging conditions (i-DREAMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Belgium,Greece,Slovenia,Belgium,Greece,Belgium,Netherlands,United Kingdom,Portugal,Portugal
Call: Human Factors in Transport Safety (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-05-01
End date: 2023-04-30
Duration (months): 48.0
Total project cost (EUR): 6265343.75
EU funding (EUR): 6265343.75
Participants: 13
Project status: SIGNED

The objective of this project is to setup a framework for the definition, development, testing and validation of a context-aware ‘safety tolerance zone’ for on-road driving, within a smart Driver and Road Environment Assessment and Monitoring System (i-DREAMS). Taking into account, on the one hand, driver-related background factors (age, driving experience, safety attitudes and perceptions, etc.) and real-time risk-related physiological indicators (e.g. fatigue, distraction, stress, etc.), and on the other hand, driving task-related complexity indicators (e.g. time of day, speed, traffic intensity, presence of vulnerable road users, adverse weather, etc.) a continuous real-time assessment will be made to monitor and determine if a driver is within acceptable boundaries of safe operation (i.e. safety tolerance zone). Moreover, safety-oriented interventions will be developed to prevent drivers from getting too close to the boundaries of unsafe operation and to bring back the driver into the safety tolerance zone. These interventions will be composed of both real-time interventions, i.e. in-vehicle while travelling, and other interventions aimed at enhancing the knowledge, attitudes, perceptions and behavioural reaction of drivers with respect to safety-related technologies, situations and behaviours. Application areas will include: new road safety interventions, improved driver well-being and transfer of control between human and vehicle. Initial testing will take place in a driving simulator environment after which promising interventions will be tested and validated under real-world conditions in a testbed consisting of 600 drivers in total across 5 EU countries. Market roadmaps will be developed to support smooth transition of the investigated technologies to the market and experience from use cases in different European countries will be used to disseminate best practices.

Keywords: subtopic a,driver behaviour,road safety,vehicle automation
The radius of Generalized Trust among different educational groups: Are those 'most people' out-groups? (Trust Radius)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-04-01
End date: 2020-12-18
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

European countries experience an increasing policy concern about migration’s impacts on social cohesion. Social cohesion is understood as ‘solidarity’ and ‘togetherness’, often measured by generalized trust. However, studies using think aloud data demonstrate that many respondents high in generalized trust think ‘most people’ refers to people they know, whereas a high proportion of those low in trust think about strangers. Thus this project starts by recognizing that generalized trust is not necessarily the same as lack of prejudiced feelings about out-groups and aims to return to the overlooked basics: the operationalization of generalized trust, which is allegedly in decline by ethnic diversity. Furthermore, this project aims to relate attitudes to implicit measures and behavior in a controlled setting, which is ignored in previous research. Failure to accurately map the relation between generalized and out-group trust may not only lead us to possibly overestimate or underestimate their incidence in different settings, but it also conceals clear public policy directions. The first two objective of this research are: to examine the measurement similarity between generalized and out-group trust among educational groups with the aid of think aloud data and invariance testing. The third objective is to experimentally assess how well these attitudes relate to less socially desirable measures, namely reaction time in associating out-groups and in-groups with (un)pleasant words and how far research participants choose to sit away from in-groups and out-groups as social distance. Results from this project will benefit governmental agencies and academics seeking to map social cohesion by providing better quality indicators. Furthermore, the EF will enable the candidate to further develop her position as a leading academic in political psychology. This project, finally, contributes to an overarching policy area of the EU in enhancing social inclusion and inclusive growth.

Keywords: generalized trust,out group trust,implicit association,out group bias,prejudice,social distance,cognitive interviews,measurement invariance,experiments
Innovation associate for future automatic mobile machining (FAMM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2020-02, 2020)
Start date: 2020-10-01
End date: 2021-09-30
Duration (months): 12.0
Total project cost (EUR): 148535.73
EU funding (EUR): 103975.01
Participants: 1
Project status: CLOSED

Picum offers a highly accurate mobile machining platform. Picum reverses the principle “the workpiece comes to the machine”. Our system comes to the workpiece. This is especially beneficial for large components, which are difficult to transport and don’t fit into most machining centres. Our customer requests are often repair and modification tasks. These tasks occur when the components are already at the usage site and not at the production site. In this case, a mobile system is highly beneficial, because transportation of the heavy work piece can be avoided. The platform can perform additive manufacturing with a welding process and metal cutting with a milling process. The system can operate automatically in its working space. However, an operator is currently needed for positioning the machine correctly in respect to the workpiece. The usability of our system would be highly increased if it can move automatically to the workpiece and if it can position itself correctly. This way set up times would be reduced. Furthermore, the operation of our system would be simplified. A technician with one week of training could operate the machine instead of a specialised expert. The positioning of the system follows always the same steps. An autonomous positioning system is therefore a great step forward. However, every repair or modification job is different in its details. For this reason, we need a highly sophisticated automation concept which goes beyond the state of the art. Picum is currently missing the capacities in human resources to develop and implement such an automation concept. As a young start-up and a small SME, Picum is currently not competitive on the German labour marked for specialists who are able to develop such an automatization. The “INNOSUP-02-2019-2020: European SME innovation Associate – pilot” programme is a great opportunity to resolve this problem.

Keywords: autonomous systems,control engineering,automation,image processing for automation,path planning for automation,milling,welding,tooling,repairs,avoiding transports,heavy components
Quantum Thermodynamics in the Solid-state (QuThenS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1990397.0
EU funding (EUR): 1990397.0
Participants: 1
Project status: SIGNED

I propose to realize an electromechanical engine in the solid state, opening a new era of experimental exploration of thermodynamics in open quantum systems. This project leverages recent breakthroughs in the nanoscale, my own advances in quantum devices and the extraordinary control and measurement of the vibrations and displacement which I have established in carbon nanotubes. The theory of thermodynamics, commonly associated with the steam engines of the 19th century, is a universal set of laws that governs everything from black holes to the evolution of life. With modern technologies miniaturising devices to the atomic scale, thermodynamics has to be put to the test in a completely new realm. Quantum thermodynamics is a rapidly advancing field of physics, but its theoretical development is presently far ahead of experimental tests. However, rapid breakthroughs in nanoscale fabrication and measurement are now presenting us with the opportunity to develop concrete experimental foundations for exploring quantum-thermodynamic processes. Understanding the peculiarities of thermodynamics in the quantum arena will be key for the construction of nanomachines, for energy harvesting, and to master the dissipation and thermalisation of quantum systems. It will also improve the engineering basis of quantum technologies by allowing fully informed choices on device design and optimisation and it may reveal possibilities for entirely novel technologies. Realising these experiments, while now within reach, remains challenging due to the sophistication of the devices and the high-level control and measurement sensitivity that are required. My vision is to combine semiconductor qubit technology with my recent advances in nanoelectromechanical devices, to build an on-chip electromechanical engine that can access the quantum regime. My aim is to achieve unprecedented access to the particularities of thermodynamics at the nanoscale and pave the way for quantum nanomachines.

Keywords: quantum dots,carbon nanotubes,electron transport,radio frequency reflectometry,thermodynamics
Development of a low cost, high resolution 270° 3D solution for full face capture to provide low cost customised eyewear (FITSYOU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2015, 2015)
Start date: 2016-03-01
End date: 2019-06-30
Duration (months): 40.0
Total project cost (EUR): 2694930.0
EU funding (EUR): 1706187.0
Participants: 1
Project status: CLOSED

The general rise of eyewear prescriptions and the subsequent need for perfect fitting eyeglasses is partly driven by the growing ageing population, increasing effect of conditions such as myopia and hyperopia, extensive use of computers and need for protection against the sun’s ultra-violet radiation. Current eyewear prescription methods are unable to accurately account for variations in facial features e.g. size of nose, distance between eyes. Present procedures require a consumer to try out several frames before finally choosing a close fitting frame that is not necessarily a perfect fit. Poor fitting glasses can cause discomfort and misalignment of the lenses with the eyes, a problem which has resulted in dissatisfied customers returning glasses, costing an estimated €500 million/year in losses in Europe. Our solution will use 3D scanning technologies to scan a consumers’s face, identify key facial landmarks and provide accurate measurements. This will then be used to determine either the best fitting glasses or a specification for custom fit glasses that can be manufactured using 3D printing technologies. The solution will be targeted at large eyewear retailers and manufacturers where there is an opportunity to implement the solution across a large network of stores.

Keywords: scanner,3d printing,additive manufacturing,eyewear,feature characterisation,software