Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
HEPARIN AND HEPARAN SULPHATE: FROM SEQUENCE DETERMINATION TO THERAPEUTIC STRATEGIES FOR PARKINSON’S DISEASE (HS-SEQ)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Sweden,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 3998385.0
EU funding (EUR): 3848385.0
Participants: 9
Project status: SIGNED

Heparin and heparan sulphate (HS) are highly sulfated polysaccharides that reside on the cell surface and extracellular matrix of all mammalian cell types. Understanding their functions has tremendous potential to unlock the next generation of heparin-based diagnostics and therapeutics for multiple diseases including inflammatory and neurological diseases, cancer, and wound healing. Despite this promise, it is very difficult to harness this biomedical potential due to a fundamental technology bottleneck - lack of methods for the sequencing of HS structures to define the natural “HS codes” that underpin many biological functions. HS-SEQ will address this hurdle and will place Europe in the leading position in the emerging field of glycomics of heparin and HS. It is our vision that robust sequencing methods for heparin and HS will only be possible when new instrumentation will be developed that can simultaneously record multiple molecular properties such as molecular weight by mass spectrometry (MS), collisional cross sections (CCS) by ion mobility spectroscopy (IMS) and vibrational properties by gas-phase infra-red (IR) ion spectroscopy. To implement such a platform, large collections of well-defined HS saccharide standards are needed to generate reference databases that can match molecular properties to structural features. To obtain the required collection of HS saccharides, HS-SEQ will develop and implement an automated platform for chemoenzymatic synthesis of such compounds. The synthetic HS saccharides will also provide unique opportunities to develop an antibody toolkit to identify epitopes expressed by cells/tissues. Specific transformational applications of the new technology will be pursued: (i) identify HS codes that promote the generation of dopaminergic neurons from human pluripotent stem cells (hPSCs) for cell replacement therapy in Parkinson’s disease; and (ii) achieve unprecedented in-depth analysis of pharmaceutical and next-generation heparins.

Keywords: heparin,sequencing,parkinson s disease,chemoenzymatic synthesis,ion mobility mass spectrometry,infra red ion spectroscopy,phage display antibodies,cell replacement therapy
Organic Mesocrystals: Formation and controlling of oriented nanoparticles of molecular solids for drug development (OMECRY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-11-30
Duration (months): 24.0
Total project cost (EUR): 202680.96
EU funding (EUR): 202680.96
Participants: 1
Project status: CLOSED

The OMECRY research action aims to enhance the dissolution of pharmaceutical solids in the form of mesocrystals, i.e. to promote the drug development. I will also investigate the formation mechanisms of the organic mesocrystals, and influence of the different additives on these processes. The low dissolution rate and poor aqueous solubility of emerging new drug candidates limit the formulation approaches, clinical application, and marketability in pharmaceutical industry. The preparation of active pharmaceutical ingredients (APIs) in the form of mesocrystals can enhance the dissolution rate suitable for drug delivery. The voids between highly oriented nanocrystals and high surface area of hierarchical structure in the non-classical pathway of mesocrystals formation play a role in the process. Different additives can be used to control the self-assembly of particles so that avoiding mesocrystals fusion into single crystals. A suitable additive can be screened through density functional theory calculations. The microstructure of mesocrystals and its transformation and particle growth can be investigated through time-dependent experiments using SEM, TEM and laser diffraction particle size analyser. Computed Tomography will be used for the first time to obtain the density mapping of mesocrystals surface in phase contrast mode. The dissolution rates and solubility of the mesocrystals are characterized and compared to its single crystals. The feasibility of drug dissolution will be investigated through in vitro studies. Although many inorganic mesocrystals has prepared for photocatalysis, energy storage applications, formation APIs in mesocrystals is a new strategy which provides insights that are needed for further understanding of mesocrystals formations thereby improve its applications especially for drug development.

Keywords: mesocrystals,supramolecular chemistry materials chemistry aspects,dissolution,solubility,superstructure,computed tomography
Reduction of the Environmental Impact of aviation via Optimisation of aircraft size/range and flight Network (REIVON)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,France,Netherlands,United Kingdom
Call: Reduction of the environmental impact of aviation via optimisation of aircraft size/range and flight network (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-01-01
End date: 2023-10-31
Duration (months): 34.0
Total project cost (EUR): 499762.5
EU funding (EUR): 499762.5
Participants: 4
Project status: SIGNED

The main objective of REIVON is to investigate to what extent the CO2 emissions of global aviation can be reduced via an optimisation of aircraft size/range and flight network. The project will first identify the theoretical potentials for reducing CO2 emissions via optimised aircraft, network and frequency reductions. Hereby, three alternatives for an optimised global air transport system will be considered: 1) splitting long-haul flights into shorter legs; 2) reducing frequencies to the necessary minimum; and 3) a combination of 1 and 2. Moreover, REIVON will assess the impacts on stakeholders of an optimised global air transport system (ATS) and will analyse potential measures to establish such a system with optimised aircraft, network and frequency reductions. REIVON will make use of an integrated approach involving experts from multiple disciplines, including aircraft design and performance, airline fleet and network optimisation, aircraft emissions modelling, air traffic demand modelling as well as impact assessment on local and global level. The analytical steps are carried out in four technical work packages, and a fifth work package is involved with management. REIVON will use various databases and a range of state-of-the-art models and tools to support the analysis. The findings of REIVON will be documented in a number of scientific reports.

Keywords: optimisation of aircraft size,range and flight network,global air transport system,environmental impact,co2 emissions
the European Community IN PERSON: connecting people and cultures through home dining (ECINPERSON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME business model innovation (H2020-SMEINST-2-2015, 2015)
Start date: 2015-06-01
End date: 2017-09-30
Duration (months): 28.0
Total project cost (EUR): 10828345.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

The ECINPERSON project intends to bring the Withlocals home dining social marketplace model to the European Community. By introducing Withlocals in the European Community, Withlocals intends to bring a new sense of understanding and belonging among not only the people in the different countries but, as important, also among people of different cultural origins in the same country, same city or same city block. Withlocals’ home dining is easily adopted by most as cooking is a daily activity. As important, food is a key aspect of (getting to know a different) culture. The authentic, personal and memorable experience of home dining is best illustrated through the quote from Cesar Chavez, a well-known and well-respected labor union activist from the United States: “If you really want to make a friend, go to someone’s house and eat with him…. The people who give you their food, give you their heart”. The ECINPERSON roll-out strategy is based on defining two regions for Europe: the Nordic and Mediterranean regions. The Withlocals presence will be rolled out in 4-6 countries per quarter, evenly distributed over both regions and driven by the (inter-European) traveler statistics. Withlocals uses a peer-to-peer market place to connect the home dining guest(s) (be it a traveler or a local) directly with a local host that offers a home dining experience, effectively making the local host into a micro-entrepreneur. Withlocals market place will use a transactional business model where the host determines the price. Withlocals adds a 20% markup to the price. Withlocals will limit the number of bookings per host to 40-45 per year to maintain authenticity of the experience. Our planning for 2015, 2016 and 2017 will establish our presence in all EC countries. Through the funding of ECINPERSON project by the EC to the amount of € 2.5M, our target for June 2017 is 481K bookings and a EURO 1.3M revenue, supported by 28,000 hosts, 1,200 ambassadors and a team headcount of 46.

Keywords: social platform,home dining,peer to peer network
Zeros of random polynomials (RandPol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

The aim of this project is to study the zeros of random polynomials. Random polynomials appeared in the 1930's with the pioneering works of Bloch, Polya and Kac. The study of random polynomials gained a strong interest of the physicists since the 1990's due to their connexion with interaction particle systems such as electron gases (also called Coulomb gases). Random polynomials were first considered as a toy model for more complicated systems, but in the 2000's they appeared to exactly describe the behavior of certain Bose Gases. We want to understand the behavior of random polynomials at the macroscopic and microscopic scale. At the macroscopic scale, several questions naturally arise: Where can we locate the zeros? Are there isolated zeros far away from the rest of them? Can we describe the behavior of those isolated zeros? Very recent breakthrough (2019) were made in both localisation and isolated zeros for specific models of random pomynomials with some symmetry constraints. Our goal is to obtain general results on these questions. We plan to develop new ideas to tackle these questions, without relying on the symmetry structure. At the microscopic scale, we want to understand the local repartition of the zeros and the interaction between neighboors. This question lead to adapt concepts from mathematical physics such as the microscopic renormalized energy to the study of zeros of random polynomials. Recent studies also linked the local behavior of zeros of random polynomials to the zeros of Random Analytic Functions, which have a lot of connexions to several domains in mathematics (Analysis, Image processing, random matrix theory, mathematical physiqucs). The concept of renormaliazed energy is very recent (2017), and was introduced by Leblé and Serfaty to understand the local behavior of particles from a Coulomb gas. We think that this approach can lead to a new understanding of the behavior of zeros of random polynomials.

Keywords: random polynomials,coulomb gases,interacting particle systems
Gestures in nonhuman and human primates, a landmark of language in the brain? Searching for the origins of brain specialization for language (GESTIMAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-09-01
End date: 2024-02-29
Duration (months): 78.0
Total project cost (EUR): 1499192.0
EU funding (EUR): 1499192.0
Participants: 1
Project status: SIGNED

Most of language functions are under the left brain control in both left- and right-handers and involve structural asymmetries between the two hemispheres. While this asymmetry was considered as associated with handedness, such a relation has been recently questioned. Considering the strong language/gesture links in humans and the continuities between the gestural system in apes and monkeys and some language properties, we recently suggested the hypothesis of a continuity between language lateralization and asymmetry of communicative gestures in both human and nonhuman primates. Given the phylogenetical proximity between those species, comparative research on brain specialization between a non-linguistic gestural system (i.e., in monkeys) versus a linguistic gestural systems in humans (i.e., sign language in deaf) might help evaluating the gestural continuities with language lateralization in term of manual asymmetries, structural and functional lateralization of the brain. To this purpose, a first objective is to evaluate the continuities of manual and brain asymmetries between (1) a linguistic gestural system in humans using MRI in 100 adult native deaf French signers, and (2) a non-linguistic gestural system of adult baboons Papio anubis using 106 MRI brain images. A second objective is to explore the functional brain lateralization of gestures production in baboons (versus manipulation) using non-invasive wireless Infrared Spectroscopy in 8 trained subjects within interactions with humans. A last innovative objective is to investigate, through the first non-invasive longitudinal MRI study conducted from birth to sexual maturity in primates, the development and heritability of brain structural asymmetries and their correlates with gesture asymmetries in 30 baboons. At both evolutionary and developmental levels, the project will thus ultimately contribute to enhance our understanding on the role of gestures in the origins of brain specialization for language.

Keywords: brain hemispheric specialization,gestures,handedness,language evolution,nonhuman primates
Global searches for dark matter and new physics with GAMBIT using effective field theory (DarkGAMBIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The nature of dark matter (DM) is arguably the biggest mystery in fundamental physics. Many experimental efforts are underway which aim to detect this elusive matter and measure its properties, using a wide variety of techniques, however to make full use of this data a combined statistical analysis must be performed which makes use of the data from all these experiments simultaneously, and compares this data to the predictions of many different theories while including all uncertainties, correlations and theoretical nuances self-consistently. Analyses of this kind are known as "global fits". I propose to use a newly developed, open-source global-fitting tool called GAMBIT to perform the largest and most robust combined statistical analysis of DM data to date. To do this I will extend the capabilities of GAMBIT to allow it to work with a class of models known as "effective theories" which efficiently parameterise the degrees of freedom relevant to experiments at a particular energy scale, so that a global fit can be performed in a fully model-independent way. This will require several connected layers of effective theory to be utilised, to account for the different energy scales involved in the diverse set of DM experiments currently underway. The project is highly interdisciplinary and makes use of recent theoretical developments and experimental results in high energy physics, particle astrophysics, astronomy, nuclear physics, and computational statistics. The proposal will generate a transfer of knowledge to the host institution while developing the candidate's theoretical expertise in new directions, particularly particle astrophysics. The results of the project will be of wide use to the dark matter community, both in terms of direct analysis results and via the development of open-source computational tools for use in future analyses, and will provide robust guidance to experimentalists as to which dark matter candidates are the most promising.

Keywords: dark matter direct detection,effective field theories,statistical analysis,global fits
Smart modular panels for hotel and retail shop construction and refurbishment which reduces embodied energy by 30% respect to state of the art systems (WHEKEE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

European Hospitality and retail shop sectors are two of most active ones investing in the construction and the refurbishment of buildings. Foreseen global investment for them is about 27.000M€ by 2016, out from which 2.700M€ will be specifically dedicated to construction. Reasons for these high figures are the increasing of demand (+3% visitors), a relevant rate of site obsolescence (79% of sites require modernisation) and incentives to improve building energy efficiency. For the administration of these investments in new built and refurbishing, owners need smart and efficient solutions combining project costs optimisation, works unproductive time reduction and the improvement of overall building energy efficiency. In Archigroup, an experienced Italian SME so far focused in offering services of interior design to retail shops and trade fair exhibitors, they have the ambition of extending current activity to hospitality and retail shops sectors by offering a totally new product, Whekee, able to satisfy customer demands for construction better than competitors. Whekee design is extremely customizable from the combination of several elements: A wall panel system in a four layer structure, with optimal insulation properties, pre allocating electrical installations and a wide offer of customizable furniture. The result of applying Whekee is a significant reduction in construction and maintenance cost (-25%), in works duration (-20%) together with a notable increasing on overall energy efficiency for the building (5 to 10% energy savings). With Whekee project, after the boost provided by the SME instrument, Archigroup foresees growing by the creation of a new company, according to a business model specially defined for this product and through most adequate distribution channels. The foreseen financial result (in 5-year period) will be an accumulated additional turnover of 38M€, an accumulated gross profit of 6,7M€ and a ROI of 230% (2,3 times the money invested).

Keywords: interior construction,design,energy efficiency,automation
Biosolids treatment system for transformation of industrial organic wastes into sustainable and efficient fertilizer with zero emissions (BTSys)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Global annual organic waste generation is set to reach 3.4 billion tonnes over the next 30 years. Although organic waste management continues to improve in the EU, the European economy currently still loses a significant amount of potential organic matter and nutrients. Organic waste generated from agribusinesses, livestock farms, forestry businesses and even urban settlements have the potential to be recycled to obtain organomineral fertilizers. However, current strategies to treat organic waste like inertization (treating sludge with lime, water and cement to form a stable mixture) and composting (using microorganisms to transform organic wastes into fertilizer) are neither sustainable nor environmental-friendly. In addition, the fertilizer industry often uses chemical additives and the process is energy intensive. To solve these problems, Agristarbio has developed BTSys an emission-free, environmental-friendly system to treat industrial organic waste, recycle them and produce highly efficient organomineral fertilizer, reducing drastically environmental impact. Agristarbio’s solution produces an efficient fertilizer from organic waste with zero carbon emissions and no contamination of soil and water. The solution is economically viable since it effectively integrates waste management services with the added value of fertilizer production at no extra cost. The waste management services and premium grade fertilizer are offered at market price, facilitating businesses to implement circular economies. During the Phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. During the innovation project, Agristarbio intends to establish in-house laboratory for testing and optimizing nutrient content in the fertilizer, in addition to commercial activities including implementation of IP strategy, communication strategy and scouting potential customers.

Keywords: zero emissions,organomineral fertilizer,cost saving,circular economy