Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Support to the implementation of the Strategic Research Agenda (SRA) of the Joint Programming Initiative on Cultural Heritage and Global Change (JPI CH) (JHEP2)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Coordination and support actions
Countries involved: Spain,Italy,Cyprus,Norway,Belgium,Lithuania,Poland,Romania,Sweden,France,France,Netherlands,Portugal,United Kingdom
Call: H2020-Adhoc-2014-20 (H2020-Adhoc-2014-20, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 999983.15
EU funding (EUR): 999983.15
Participants: 20
Project status: CLOSED

Joint Programming is a process combining a strategic framework, a bottom-up approach and high-level commitment from the Member States (MS). It builds on the experience gained from existing schemes, coordinating national programmes by contributing to the reduction in fragmentation of research efforts of MS, stepping up the mobilisation of skills, knowledge and resources, advancing research and innovation in the specific field. The JPI in "Cultural Heritage and Global Change: a new Challenge for Europe" - JPICH - was approved by the Council was launched in January 2010. The JPICH has defined the Vision Document, the Terms of Reference, the Strategic Research Agenda (SRA), an Action Programme and a monitoring and evaluation procedure. The experience gained over the past 4 years in JPICH development and implementation has been achieved through the active participation of 17 EU MS and AC and 8 Countries participating with the role of Observers. The present CSA JHEP2 Proposal intends to support the implementation of the Strategic Research Agenda following the recommendations emerging from the High level Group for joint programming (GPC) in the Biennial Report 2014 and in the Report on "Alignment in the context of Joint Programming", which specifically address the recommendation to develop alignment of national research and innovation programmes and activities and application of qualitative and quantitative Key Performance Indicators (KPIs).The main objectives addressed within the present proposal are: - Develop effective and efficient governance of the alignment of the national research and innovation programmes. - Reinforce common activities on cultural heritage. - Apply quantitative and qualitative KPIs for monitoring an assessing the JPICH alignment process. The support to the JPICH with the present JHEP2 Proposal will be essential for achieving the above-mentioned objectives and proceed with the integration of the research area on Cultural Heritage.

Keywords: cultural heritage,alignment,action programme,national programme,key performance indicators,strategic research agenda,monitoring
Understanding Halophytes for an Agriculture Worth its Salt (HALO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Australia
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 268518.6
EU funding (EUR): 268518.6
Participants: 2
Project status: CLOSED

One of the greatest challenges of the 21st century is to meet the world’s future food security and sustainability needs despite the rapid and large declines in suitable resources needed for the agricultural expansion required in the foreseeable future. As a result, interest in saline resources has escalated over the years but, notwithstanding great efforts from the scientific and breeding community, success in the development of salt tolerant crops remains elusive. For major breakthrough in crop breeding for salt tolerance, there is an urgent need to look at new options to find previously unexplored traits and mechanisms. With a multi-disciplinary approach and state-of-the-art biophysical and molecular techniques used in plant molecular biology, ion transport biology, halophyte ecophysiology and electrophysiology, the project will reveal the fine print of one of the most interesting mechanisms evolved by plants to deal with excess salts and thrive in these otherwise hostile environments. Given that dicotyledonous halophytes use sodium as a cheap osmoticum, the main objective of the project is to unravel the complementary morphological, physiological and anatomical characteristics that enable them to deal with cytotoxic sodium. The project will focus on four distinct halophytic species (facultative vs. obligate and with vs. without salt bladders): Atriplex nummularia, Chenopodium quinoa, Salicornia dolichostachya and Beta vulgaris ssp. marittima. By understanding how these different halophytes orchestrate efficient vacuolar Na sequestration with greater cytosolic K retention and bladder cell-based desalination, this project is expected to led the way to uncharted pathways to pinpoint key biological mechanisms that could improve tolerance in traditional salt sensitive crops. Public engagement activities and contact with the scientific and agricultural community will ensure a rapid transfer of knowledge and improve the likelihood of developing new salt tolerant crops.

Keywords: salinity,halophytes
Integrated Intelligent Bearing Systems for UHPE Ground Test Demo (I²BS) (UHPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,United Kingdom
Call: Conventional and Smart Bearings for Ground Test Demo (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 1846060.0
EU funding (EUR): 1490891.88
Participants: 2
Project status: CLOSED

Smart Bearings for Ground Test Demo The overall objective of the I²BS project is to develop innovative smart bearings for an Ultra High Propulsion Efficiency (UHPE) Ground Test Demonstrator that not only meet the demo specification but also provide significant safety improvement compared to existing standards. I²BS pursues an integrated approach comprising the development of sensor technologies, energy harvesting, wireless communication, data management and algorithms to monitor bearing behaviour in challenging operating conditions (e.g. high temperature, high speed and high thrust). As part of the UHPE Demonstration Project, I²BS will design, develop, evaluate and test interchangeable smart bearings for the UHPE demonstrator. The bearing design will fulfil all requirements and safety standards for aerospace applications. The ‘smart’ bearings will be able to deliver, in real time, information on the bearing’s main functional characteristics and health including temperature, axial & radial load, ball or roller or cage speed, lubrication quality, radial clearance and premise of failure on each part of the bearing.

Keywords: smart bearing,sensing system,intelligent detection
Deep Learning for Automated Quantification of Radiographic Tumor Phenotypes (CANCER-RADIOMICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-08-01
End date: 2025-07-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Artificial Intelligence (AI), deep-learning in particular, is propelling the field of radiology forward at a rapid pace. In oncology, AI can characterize the radiomic phenotype of the entire tumor and provide a non-invasive window into the internal growth patterns of a cancer lesion. This is especially important for patients treated with immunotherapy as, despite the remarkable success of these novel therapies, the clinical benefit remains limited to a subset. As immunotherapy is expensive and could bring unnecessary toxicity there is a direct need to identify beneficial patients, but this remains difficult in clinical practice today. Radiomic biomarkers could address this, as, unlike biopsies that only represent a sample within the tumor, radiomics can depict a full picture of each cancer lesion with a single non-invasive examination. Previous work found significant connections between radiomic data, molecular pathways, and clinical outcomes. However, a direct link between radiomics and immunotherapy response has not yet been established. This project will address this problem by analyzing unique multicentre clinical data, including non-invasive imaging, clinical outcomes, and extensive biologic characterization of patients with lung or melanoma cancer. Specifically, I will develop deep-learning radiomic biomarkers to predict immunotherapy response using baseline (WP1) and follow-up imaging (WP2). I will also investigate if radiomics can characterize underlying biological factors, and, in turn, can be used to improve response predictions (WP3). Successful completion of this proposal will demonstrate the potential of radiomics to help physicians in selecting patients who will likely benefit from immunotherapy, while sparing this expensive and potentially toxic treatment for patients who don't. This work has implications for the use of imaging-based biomarkers in the clinic, as they can be applied noninvasively, repeatedly, and at low additional cost.
Thinking Deep-Novel Creative Approaches to the Underground (THINK DEEP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1940685.0
EU funding (EUR): 1940685.0
Participants: 1
Project status: SIGNED

THINK DEEP pioneers a creative practice driven interdisciplinary approach to the underground. It begins from the dual premise that, firstly the underground (or subterranean) is both the site of current environmental concerns (e.g. extraction), and the setting for developing solutions to these concerns. But that secondly, currently we lack approaches that adequately understand the underground, its current use and conservation, and its future possibilities. Underground scholars have long argued that what is needed is an interdisciplinary approach, as yet, however, where interdisciplinarity has been achieved, it has largely brought together science and social science. Unconventionally, THINK DEEP situates creative practices (such as visual art or participatory theatre) together with arts and humanities theories as the cornerstone of an interdisciplinary response to three pressing underground research problems: 1. How to sense the underground, an often inaccessible environment? 2. How to contend with varied underground imaginations, which shape underground understanding, use and conservation? 3. How to understand the speculative nature of ‘knowing’ the underground? It will address these problems through global case studies from three fields of underground research: geoscience, underground urban studies, and geoconservation. Its unconventional ambition enables THINK DEEP to deliver a timely and distinctive new contribution to underground scholarship that will transform the field’s future research directions. Furthermore, the project’s pioneering approach will bring about a step-change in relations between creative practices and research more generally. In understanding and evaluating the creative practice and research relations that sit at its heart, THINK DEEP enables ground-breaking understandings of these relations, and of their profound possibilities with respect to a range of research fields, including those which engage pressing environmental issues.

Keywords: cultural geography,underground,arts practice based research,geohumanities
Characterization, documentation and virtualization of the cultural masonry heritage using wave propagation Non-Destructive Techniques (DocumeNDT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: TERMINATED

DocumeNDT aims at developing improved characterization, documentation and dissemination strategies for the architectural and archaeological masonry heritage, by offering a new approach to evaluate, record and present buildings and archaeological ruins. The project proposes to develop an improved methodology for the in situ non-destructive evaluation of the masonry built heritage, based on wave propagation Non-Destructive Techniques (NDT), namely sonic, ultrasonic and Ground Penetrating Radar (GPR) tomography. Tomographic techniques allow visualizing and documenting the interior of masonry construction elements, typically hidden to our naked eye. In combination with existing state-of-the-art technologies developed for the accurate visual 3D reconstruction of our monuments, such as photogrammetry and 3D laser scanning, this information can provide a precise characterization of the exterior and interior morphology of the masonry element. The project ultimately aims to offer a complete 3D reconstruction of monuments. The complete 3D reconstruction of both the exterior surfaces and interior of masonry heritage and archaeological ruins has three fundamental purposes: (i) material mechanical characterization of historical masonry by obtaining specific correlations among elastic properties, geometry (internal and external), and wave propagation attributes, acknowledging that the velocity of waves propagating through a material is related to its physical and mechanical properties; (ii) documentation of the cultural heritage with full 3D digital models with unique information on the construction know-how of ancient builders, reconstructing the monuments on an almost stone-by-stone basis; and (iii) virtualization of the cultural heritage by implementing the digital models into a web open access virtual repository freely available to enhance accessibility to cultural heritage for all, both the general and specialized public.

Keywords: architectural heritage,archaeological heritage,historical masonry,conservation,non destructive testing,material properties,documentation,virtualization,tomography,3d digital modelling
Understanding the Role of Motors in Subcellular Mechanics of Organelles by Controlling Myo6-Cargo Interactions in situ (MELANCHOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Mechanical forces play crucial roles in the formation and maturation of many organelles and membrane vesicles. Many of these forces originate in the action of cytoskeletal motors, but how these motors are activated and how their mechanical functions are regulated in the cell are poorly understood. Rather than being “always on” machines, motors must often be specifically activated for distinct mechanical roles by partners. The MELANCHOR project seeks to uncover how Myosin VI (Myo6) promotes two cell processes through specific interaction with partners that promote different Myo6 dimerisation modes with unique mechanical properties. Myo6:GIPC1 complexes aid in endosomal trafficking through the actin cortex while Myo6:Optineurin complexes promote melanosome biogenesis through a membrane recycling pathway. Two complementary approaches will uncover the functions of Myo6. (1) Optogenetic tools will control Myo6 targeting to endosomes or melanosomes in live cells, with simultaneous functional imaging, to precisely localize the effect of Myo6 in space and time. (2) Novel in vitro motility methods will determine the effect of different Myo6 partners on Myo6 activation and mechanics under tension. Finally, a combined approach will address the mechanical role of Myo6 in these organelles– whether it is a tension-bearing anchor, transporter or weak tether. The MELANCHOR project raises the exciting prospect of using optogenetic tools to provide real-time information on subcellular mechanics. By integrating cellular and in vitro approaches to measure the tension in individual Myo6 motors, an unprecedented level of detail on the cellular function of motors will be made possible. These novel techniques will help shed light on motor function in processes such as intracellular trafficking, cell migration, and cancer cell proliferation, invasion and metastasis.

Keywords: myosins,actin cytoskeleton,intracellular trafficking,endocytosis,melanosome biogenesis,optogenetics,live cell imaging,cell motility,mechanobiology
Epigenetic regulation of cardiac regeneration after injury. (HeartATAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Cardiovascular disease is a leading cause of morbidity and mortality worldwide, and there is a constant and urgent need for novel, more effective therapies to treat it. Chronic tissue hypoxia, nutrient deprivation and myocardial cell death are some of the factors contributing to ischemic heart disease (IHD), the most common cause of death from all cardiovascular diseases. Current therapeutic approaches are limited in their capacity to enhance cardiac regeneration after injury. Toward novel selective therapies, it is important to gain a detailed understanding of pathways orchestrating cardiomyocyte proliferation during development and after injury. This proposal aims to map the epigenetic landscape of cardiomyocytes at key stages of postnatal cardiomyocyte maturation, using the assay for transposase accessible chromatin with high-throughput sequencing (ATAC-Seq). The application of this novel technique to cardiomyocyte biology will allow for the identification of epigenetic mechanisms that drive cell cycle withdrawal during cardiomyocyte maturation. My pilot experiments indicate that the SWI/SNF chromatin remodeling factor Arid1a may prevent efficient cardiac regeneration after injury. The role of Arid1a during cardiomyocyte maturation will be characterized. Furthermore, I will examine if suppression of Arid1a in adult mouse heart can improve cardiac function and enhance regeneration after injury. Mapping the epigenetic landscape of developing and mature cardiomyocytes represents an important step toward understanding the obstacles to efficient myocardial regeneration. Manipulation of Arid1a in diseased hearts may provide novel therapeutic approaches to enhance cardiac regeneration post ischemic injury.

Keywords: cardiac regeneration,ischemic injury,chromatin remodeling
HiLASE Centre of Excellence (HiLASE CoE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Czechia,United Kingdom
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 494831.0
EU funding (EUR): 494831.0
Participants: 3
Project status: CLOSED

Czech Republic has invested €32M in the construction of an advanced, "next generation" laser, HiLASE, at Dolní Břežany in Central Bohemia Region. HiLASE will be commissioned in 2015 as a major laser facility of the Czech Institute of Physics (IoP) with the potential to be an outstanding science and technology asset for the region and for Europe. This Teaming Action will transform HiLASE from a state-of-the-art laser into a Centre of Excellence, serving a broadly based scientific and industrial user community, stimulating innovation and developing the technology itself to ensure that the Centre is sustainable and competitive in the long term. This will enable the Centre to fulfil its role as a driver of scientific excellence and a generator of economic impact, thus raising the region's innovation performance. The IoP will team with the Central Laser Facility (CLF) at STFC's Rutherford Appleton Laboratory in Oxfordshire, UK. CLF is widely regarded as a world leader in both the delivery of advanced laser facilities to a large and diverse international user community, and in the development of the "next generation" laser technology which is at the heart of this proposal. CLF staff will be assisted by STFC’s Business and Innovations Directorate who will identify innovation opportunities and drive the transition from academic experiments to industrial applications. Partnership with STFC will ensure that the Centre is "up and running" as a new user facility as quickly as possible, that opportunities for innovation and exploitation are identified and developed, and that a cutting edge facility enhancement programme is delivered efficiently, on time and with the best value for money. This will ensure the success of the Centre for the duration of the Teaming Action, the competitive edge of its facilities and its sustainability into the future.

Keywords: centre of excellence,laser technology,czech republic,central bohemia region,diode pumped solid state laser architecture