Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of minimally invasive neuromodulatory electroconductive hydrogel in combination with physical stimuli for spinal cord regeneration (MINECHPS-SCI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: CLOSED

Spinal cord injury (SCI) is a debilitating health conditions affecting circa 27.04 million people globally including 6.4 million Europeans with serious impact on the quality of life and socio-economic status of the patients. Existing regenerative and rehabilitation approaches are largely palliative and neuroprotective, targeting the spared neural tissue after injury with limited efficacy in regeneration. While the spinal cord has poor regenerative ability, the degenerative processes further complicate the SCI pathophysiology. Hence, no regenerative and rehabilitation approaches, individually, have resulted in complete and near complete functional recovery to date. To fully restore the injured spinal cord's functionality, a coordinated combinational approach addressing particular degenerative processes is necessary. Herein, the fellow proposes to develop a regenerative-rehabilitation combinational approach to maximize the functional regenerative outcome after SCI using minimally invasive injectable electroconductive hydrogels (ECHs) functionalized with neurotrophins (NTs) and anti-inflammatory cytokines in combination with electrical stimulation (ES) and near infrared (NIR) laser stimulation. ES and NIR laser through the ECH will be used to stimulate the neurons and glial cells to enhance regeneration and neuroplasticity as well as for on demand delivery of biologics to target the inhibitory processes. This proposal describes the project's multidisciplinary nature, execution and management of the project by the fellow and the multiple collaborators who will each provide the fellow with cutting-edge research skills. The goals of the fellow’s project place specific focus to ensure that the training of the fellow brings him to a level of competitive scientific excellence at international level.

Keywords: electroconductive biomaterial,electrical stimulation,light stimulation,immunomodulation,spinal cord injury
Biotechnological tools for assisting seagrass natural recovery in the Mediterranean Sea (SEACOVERY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2028-06-30
Duration (months): 30.0
Total project cost (EUR): 242054.1
EU funding (EUR): 242054.1
Participants: 3
Project status: SIGNED

Current degradation of marine ecosystems, worsen by global change processes, have triggered scientific and public awareness for environmental conservation. That is the case of seagrass meadows, unique coastal habitats which provide a variety of ecosystem services, play essential roles in coastal ecology and biogeochemistry and are endangered by human development. Even though seagrass restoration might be locally helpful with some species, in the case of the iconic Mediterranean species Posidonia oceanica, conservation and recovery of the existing meadows is the most urgent topic to be addressed. However, there is a lack of knowledge regarding the active strategies which could be applied to enhance present meadow's tolerance and future resilience to environmental stressors. Through an interdisciplinary approach based on assisted genetic migration, active priming strategies, assisted ecological succession and science communication, SEACOVERY project will explore new insights into assisted recovery techniques and increase awareness in local communities. My experience in seagrass ecotoxicology and population dynamics will be complemented with the recognised expertise on assisted evolution and transcriptomic responses of Dr. Gabriele Procaccini (SZN, Italy), combined with the essential knowledge on seagrass physiological and ecological responses to environmental stressors of Dr. Lázaro Marín-Guirao (IEO-CSIC, Spain). The outreach of this research will be augmented thanks to the placement with the CSI Gaiola onlus, which will support science communication and education events. SEACOVERY will provide an urgently needed knowledge on assisted natural recovery of P. oceanica meadows, with the potential of being a cost-effective climate change mitigation strategy.

Keywords: posidonia oceanica restoration assisted recovery priming transcriptomics
Striking Stroke- enhancing and expanding StrokeAlert’s business skills (StrokeAlert- WomenEU)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Israel
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-07-01
End date: 2023-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Our vision is to preserve Improve the quality of life by reducing silent stroke impact. We will develop, manufacture, and introduce the first easy-to-use device for alerting stroke for high-risk populations. The first market is hospital use during sedation, with the end-stage market being home telemonitoring. The company has a clear patentable product, a large growing market, and an expert and experienced team. StrokeAlert's intellectual property is an alerting system via continuous monitoring of hemodynamic parameters (patent submitted). StrokeAlert's impact will be reducing morbidity and mortality from stroke. We shall compare patients' neurological outcomes with and without StrokeAlert.

Keywords: bio convergence,medical device,stroke prevention,wellness,telemedicine
NGI0 Commons Hop On (NGI0 Commons Hop On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Netherlands,Czechia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 499375.0
EU funding (EUR): 499375.0
Participants: 2
Project status: CLOSED

This proposal aims at increasing the visibility of the NGI Zero Commons granting programme, to promote its output and its grant mechanisms. We will increase the interaction with scientific and technical output throughout the region of Central and East Europe and beyond - which due to the nature of the funding scheme (small, early stage grants for deep tech) requires continuous attention to reach the right talent. The value of the addition of BUT as widening partner lies in two partially overlapping aspects which are currently not present within the programme: a significant investment in promoting and growing mindshare for the individual technological building blocks produced by NGI Zero, and through that also much more active and directly targeted engagement with the talent pool present in the geography covered by HopOn/WIDERA. This means we communicate on two layers: direct outreach to target audiences promoting ethical open technologies as well as evangelising the recursive opportunity to researchers and developers to contribute to the underlying portfolio of technology commons. We put reusable technological building blocks on display, but in a co-creation way: anyone can jump in and improve and add more functionality or tweak to new use cases. Outreach activity was limited by design so far (due to priorities set early within the project on technical excellence and long term societal impact. The new effort will build a network of technical universities and other interested parties across Europe interested in contributing to the open internet and the technology commons. This part will seek to engage educational and research institutions with cutting edge work on open standards and open source from developers and researchers executed within NGI Zero Commons, and empower them to join this effort and benefit from the results.

Keywords: user centric privacy preservation,digital identity,internet services and applications,trustworthy ict,data portability,trustworthiness,oshw,open source,free software,foss
6G Terahertz Communications for Future Heterogeneous Wireless Network (6G-TERAFIT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal,United Kingdom,Spain,Greece
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 659114.29
EU funding (EUR): 611800.0
Participants: 8
Project status: SIGNED

With the fast development of electronic devices and computing technologies, various emerging applications (e.g., big data analysis, artificial intelligence and 3-dimensional (3D) media, Internet of things, etc.) have been entering our society with significant amounts of data traffic. While mobile networks are already indispensable to our society for “anywhere anytime connection,” one main characteristic of future mobile networks (i.e., B5G: Beyond 5G) is the very huge amount of data, which requires very high throughput per devices (multiple Gbps, up to Tera bps: Tbps) and multiple Tbps per area efficiency (Tbps/km2). Though some disrupting 5G technologies may provide a few Gbps service, it is still not able to achieve hundreds of Gbps or Tbps rates. In the near future, the peak rate of mobile communication networks is expected to reach hundreds of Gbps or even Tbps rates, which requires either very high spectrum efficiency (e.g., much higher than 10 bits/s/Hz) in millimetre wave bands or very large bandwidth (e.g., more than 20GHz) . While the former is very challenging, the latter can be achieved in THz bands (roughly, 100GHz to 10THz). The design of ubiquitous access with very high rates in mobile and heterogeneous network (HetNet) environments is the key to the development of future mobile networks, and so the objective of this collaborative 6G-TERAFIT is to create a knowledge transfer between the researchers and the engineers who will contribute to the design and implementation of future B5G ultra-fast networks and create the pedestal for them to become potential leaders in the resulting scientific, technological, and industrial fields. This project is committed to creating an “excellent” educational training platform that is multi-disciplinary and inter-sectoral in nature.
High entropy alloy catalysts for hydrogenation of biomass derived oxygenates (HEABC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-15
End date: 2027-07-14
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 2
Project status: SIGNED

In the proposed project, we will study high entropy alloy (HEA) materials as an alternative to noble metals for liquid phase biomass processing. Non noble metal catalysts suffer from stability issues during liquid phase biomass transformation, owing to sintering, oxidation induced leaching, poisoning. Noble metal catalysts are often used in hydrogenation, hydrodeoxygenation reactions of biomass derived oxygenates, making the process expensive, which is one of the reasons why biomass derived products are not widely adopted in industry yet. We believe HEAs of non-noble metals can solve this problem. This project combines the researcher's expertise in material science and advanced characterization methods with the host's knowledge of biomass conversion and is further enriched by the co-supervisor's background in theoretical chemistry. Together, these strengths will drive the development of new sustainable catalytic materials for biomass conversion.

Keywords: high entropy alloy,heterogeneous catalysis,biomass conversion,non noble metal,spectroscopic characterizations
Exploring the landscape of biomolecular condensates in enterovirus infection (BARONET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

The genus Enterovirus comprises many important human pathogens (e.g. polio-, coxsackie-, and rhinovirus) that cause a wide array of diseases ranging from mild to life-threatening. As there are hundreds of enteroviruses and vaccination to all of these is not feasible, there is an unmet need for pan-enterovirus antiviral drugs. Hence, we need to deepen our knowledge on the enterovirus life cycle and virus-host interactions. Mammalian cells express an arsenal of sensors that function to restrict virus replication and spreading. These include RIG-I and MDA5, which recognize viral RNA and trigger expression of type I interferon (IFN), and PKR, a kinase that upon recognition of viral RNA blocks translation and triggers the formation of membrane-less condensates, so-called stress granules (SGs), that serve as platform for RIG-I and MDA5 signaling. On the other hand, viruses have developed sophisticated mechanisms to suppress antiviral responses. The enterovirus 2A protease (2Apro) has been recognized by the host lab to antagonize SG formation and IFN-gene transcription. Emerging evidence points towards the existence of many more types of condensates with a role in antiviral signaling, such as PKR clusters, RNase L bodies, and cGAS foci. Unfortunately, comprehensive insight into the composition, formation, and dynamics of these condensates in infected cells are missing. In this project, I aim to comprehensively characterize antiviral condensates in cells infected with wild-type enterovirus or a 2Apro inactive mutant. I will use state-of-the-art microscopy approaches, including an assay that was recently developed by the host lab and that allows real-time visualization of the viral life cycle. Besides, I will assess the role of condensates as signaling platforms that connect stress sensors with effectors of the innate immune response in infected cells. This project will provide insights into enterovirus-host interactions and may uncover new targets for antiviral therapy.

Keywords: human pathogen,enterovirus,viral replication cycle,biomolecular condensates,liquid liquid phase separation,antiviral response
Deconstructing Intestinal Immune Tolerance (DeconstrucTolerance)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The intestinal tract is the main site of nutrient absorption and faces constant exposure to complex environmental stimuli. Intestinal barrier integrity and functionality are safeguarded by the intestinal immune system, which must balance its pro- and anti-inflammatory activities to provide protection from pathogenic microorganisms while preventing unwanted reactivity to self-antigens, commensal microbes, and dietary components. The intestinal immune environment can be viewed as a multicellular network in which the identity and function of individual cells is intrinsically programmed by transcription factors (TFs) that regulate their gene expression. These cells in turn can respond to signals in their environment and impact the behavior of their neighbors, which over time drives changes in tissue physiology. Conventional genetic knockout approaches offer insufficient temporal resolution to dissect these regulatory layers. In this proposal, we will employ chemical genetic protein degradation using the auxin-inducible degron 2 (AID2) system to “deconstruct” the intestinal immune regulatory network. These studies will focus on the role of Foxp3+ regulatory T (Treg) cells, whose continuous immunosuppressive activity is required to prevent the onset of intestinal inflammation. In Aim 1, we will use newly generated mouse models to probe the direct gene regulatory functions of key TFs that define intestinal Treg cell subsets. In Aim 2, we will fluorescently label intestinal Treg cells and rapidly degrade the TFs that confer their suppressive activity to study their functionality in situ. Finally, in Aim 3, we will use a reversible mosaic protein degradation strategy to study how the signals that precede and promote intestinal Treg cell differentiation shape the developing intestinal immune system. Together, these studies will provide fundamentally new insights into the regulatory network underlying intestinal immune tolerance.
Towards Primate-like Artificial Neural Networks for Visual Object Tracking (PRINNEVOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Canada
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 256442.88
EU funding (EUR): 256442.88
Participants: 2
Project status: SIGNED

The PRINNEVOT project embarks on a mission to bridge the gap between computer vision and the primate visual system in the context of Visual Object Tracking (VOT). VOT is the task of maintaining focus The PRINNEVOT project embarks on a mission to bridge the gap between computer vision and the primate visual system in the context of Visual Object Tracking (VOT). VOT is the task of maintaining focus on a specific object amidst a dynamic visual environment. Our brains excel at it but replicating this ability in artificial vision systems remains a challenge. This project seeks to develop a novel class of VOT algorithms inspired by the primate visual system's prowess. Despite notable advancements in deep learning-based VOT over the past decade, these algorithms still fall short in emulating the robustness exhibited by primate vision. PRINNEVOT will address this gap through a multi-faceted approach. Firstly, PRINNEVOT will construct a comprehensive reference dataset, investigating both primate behavior and neural recordings. Secondly, among the existing artificial neural network (ANN)-based VOT methodologies, the project aims to identify those that align most closely with the primate brain's mechanisms. Lastly, PRINNEVOT will leverage the discovered inductive biases to develop a new ANN architecture for VOT that closely mirrors the primate's way of continuous object recognition and localization. By merging computer vision and computational neuroscience research, PRINNEVOT aspires to contribute to the development of more accurate and robust VOT algorithms. These algorithms, in alignment with the European Union's pursuit of safer and ethically grounded Artificial Intelligence, promise to enhance human-centric and trustworthy technologies. Furthermore, the project's outcomes will not only benefit AI and computer vision but also advance our understanding of the primate visual system, offering new empirical models of how the brain tracks objects in dynamic visual environments.

Keywords: computer vision,visual neuroscience,visual object tracking,deep learning
Bulk rare earth free permanent magnets (REFMAG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-04-01
End date: 2023-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Permanent magnets are essential components of an enormous amount of consumer and industrial products. Their production rises annually, especially due to their use in fast growing green technologies such as electric mobility. High performance magnets with a large energy product are usually based on the NdFeB material system. The major components are rare-earth elements, which are listed as critical materials. Novel permanent magnets use the concept of magnetic coupling effects. In course of the ERC Starting Grant SPDTuM we have developed a new processing route to synthesize permanent magnets based on this concept. The objective of this ERC PoC Grant is to use this processing route and apply it to the MnBi system, which represent a rare-earth free alternative to the currently used NdFeB magnets. As additional benefit, the magnetic α-MnBi phase exhibits an increasing coercivity with rising temperature. Thus, magnets based on MnBi will be especially well-suited for high temperature applications. We use high-pressure torsion, a severe plastic deformation method, for processing, which has the advantage that the key α-MnBi phase can be directly formed during processing. Coupled to a soft magnetic phase, a high performance permanent magnet with an excellent energy product will be obtained. So far, this type of magnet has only been successfully obtained in limited volumes (thin films, powders). With our processing route it is possible to synthesize magnets in dimensions with about 100000 times larger volume. The novel MnBi permanent magnets will be characterized with state-of-the-art methods in terms of their microstructure and magnetic properties. The up-scaling potential of the developed processes from laboratory to industrial conditions will be further critically evaluated. These activities will be complemented by patent protection to facilitate commercialization and outreach to potential industry partners for the introduction of our novel method and new collaborations.