Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Signal Integration by Gene Regulatory Landscapes (INTEGRAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-08-01
End date: 2022-01-31
Duration (months): 66.0
Total project cost (EUR): 2499500.0
EU funding (EUR): 2499500.0
Participants: 1
Project status: CLOSED

Identification of the molecular mechanisms by which gene regulatory landscapes integrate diverse signaling inputs into a robust and dynamic transcriptional output is key to a comprehensive mechanistic understanding of the systems that govern vertebrate organogenesis. We will tackle this by taking advantage of our in-depth knowledge of the self-regulatory signaling systems controlling vertebrate limb development. To capture the dynamics by which the major signaling pathways (BMP, SHH, WNT, FGF) interact to control gene expression, we will profile chromatin architecture, epigenetic marks and the interaction kinetics of transcriptional effectors with cis-regulatory modules (CRMs) during mouse limb bud development. First, we will focus on the Grem1 gene regulatory landscape, as this BMP antagonist is a key node in the system and its spatio-temporal expression is regulated by all four pathways. This analysis will capture the temporal activity of all CRMs in the Grem1 landscape and reveal the ones that are targets of one or several signaling pathways. The functional requirements of single and multiple CRMs with redundant functions will be assessed by gain- and loss-of-function genetics in mice. This analysis together with in silico simulations of the relevant interactions aims to reveal the underlying regulatory logic. Second, the genome-wide datasets will be used to analyse the gene regulatory landscapes of signals involved in epithelial-mesenchymal and auto-regulatory feedbacks. Third, the trans-cis regulatory alterations underlying the evolutionary diversifications that resulted in digit loss and reductions will be functionally studied by comparative analysis of mouse, bovine, pig and chicken limb buds. Finally, as aberrant Grem1 expression predisposes to various diseases and cancers, we will study the trans-cis regulatory alterations that affect the Grem1 landscape in a mouse model of SHH-induced cerebellar medulloblastomas, which depends on aberrant Grem1 expression.

Keywords: limb development,gene regulatory networks,signaling systems,evolutionary diversification,disease
Improving the services of the NMP NCP Network through Transnational Activities 4 (NMP TeAm 4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Coordination and support actions
Countries involved: Israel,Germany,Italy,Cyprus,Poland,Greece,France,Portugal,Portugal,United Kingdom
Call: Support for National Contact Points (H2020-NMBP-CSA-2016, 2016)
Start date: 2017-01-01
End date: 2020-03-31
Duration (months): 39.0
Total project cost (EUR): 599992.5
EU funding (EUR): 599992.5
Participants: 12
Project status: CLOSED

NMP TeAm 4 is a proposal for a 27 months continuation of the successful EU projects NMP TeAm 1,2&3. It aims to facilitate transnational cooperation between NCPs within the Industrial leadership Part with a view to identifying and sharing good practices and raising the general standard of support by the NMP NCPs to programme applicants as described in the work programme. NMP TeAm 4 will achieve a consistent, improved and more professional NCP service across Europe, thereby helping simplify access to H2020 calls, lowering the entry barriers for newcomers and raising the average quality of proposals. NNP TeAm 4: - Will create the mechanisms and tools for capacity building of NCPs' skills that will ensure the NCP Network's high and consistent level of services to clients. These will include 4 training events, 4 virtual trainings for less experienced NCPs, 4 twinning schemes and self -assessment through benchmarking. - Will provide the necessary tools to all NMP NCPs so that they can assist their clients to increase their success rate in H2020 and lower the barriers for participation for new applicants. These will include the improvement of the Partner Search Facility of NMP TeAm 1,2&3, organisation of 4 brokerage events at large EU presidency conferences and 8 virtual training seminars for NCPs, stakeholders and clients on H2020. - Will improve the outreach of the NMP NCP Network and maximise the impact of its activities, services and results to a wide audience of clients and stakeholders. This will be achieved through the continuation of the NMP TeAm website, continuous dissemination of information through social media and participation of NCPs at large NMP related events to provides assistance and services on the spot. NMP TeAm 4 will also maintain and create new links with stakeholders at European and regional level like the Enterprise Europe Network, European Technology Platforms, other NCP Networks and key regional stakeholders to reach as many clients as possible. Project website : http://www.nmpteam.com/

Keywords: national contact points,support to horizon 2020,benchmarking for ncps,capacity building for ncps and h2020 applicants,brokerage events,partner search for h2020 applicants
Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair (Tendon Therapy Train)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,Germany,Ireland,Greece,Greece,France,France,France,Netherlands,United Kingdom,Portugal,United Kingdom,Canada,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 3876965.65
EU funding (EUR): 3876965.6399999997
Participants: 17
Project status: CLOSED

Tendon Therapy Train is a research, training and innovation programme for human and equine tendon repair and regeneration that will exploit recent advancements in tissue engineering by self-assembly (TESA) technologies which have led to the clinical translation and commercialisation of advanced therapy medicinal products (ATMPs). Although TESA therapies have the potential to revolutionise healthcare for numerous clinical targets, a lack of researchers with the necessary interdisciplinary skillset to advance the field is limiting clinical translation. Tendon therapy train, a network of 8 beneficiaries and 8 partners (7 universities, 7 companies and 2 hospitals) from six countries across Europe, will train a cohort of 15 researchers to doctoral level in the interdisciplinary area of ATMPs. The innovative credentials of the research and training programme involve engineering suitable ex vivo culture environments that, by mimicking the native tendon tissue milieu (human and equine), will maintain the tenogenic phenotype of tendon derived cells and differentiate non-tendon derived cells (stem cells and dermal fibroblasts) towards the tenogenic lineage, subsequently enabling development of three-dimensional cell-assembled tissue equivalents, the clinical potential of which will be assessed in suitable preclinical models. The comprehensive Tendon Therapy Train programme will equip researchers with transferable inter- and multidisciplinary skills that will further European-based knowledge, innovation, competitiveness and leadership in the field of TESA / ATMP and ultimately enable clinical translation and commercialisation of the developed technologies.

Keywords: tissue engineering by self assembly,in vitro microenvironments,tendon repair and regeneration,advanced therapy medicinal products
Improve SMEs experience from Innovation Support Programmes (DestinationUX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Poland,Greece,United Kingdom
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2018)
Start date: 2019-09-01
End date: 2021-02-28
Duration (months): 18.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

DestinationUX aims to use the experience, the tools, the capacity and the partners’ knowledge in order to address a common innovation support challenge namely to increase the satisfaction and the participation of SMEs to existing and future innovation programmes through the creation of tailor-made toolbox regarding SMEs Experiences from Innovation Support Programmes. The toolbox/guide, entitled “Design Option Paper”, willhelp innovation agencies to : - map SMEs journey when participating in an innovation programme - identify the level of satisfaction per stage - find the gaps/ issues and improve the process Intermediary organizations offering support services on Innovation to SMEs are relevant actors in this process from two main points of view: 1) they can help policy makers in the development and application of programmes, 2) they can support SMEs to become more innovative. The Peer learning activity will serve to learn from the best and to share good and bad practices in increasing the satisfaction of innovation programmes to SMEs that will lead to better results and greater impact of the innovation programmes. In a few words the DOP will help innovation agencies to create better programmes for SMEs, with more impact, using less money and resources.

Keywords: innovation support schemes,smes,innovation agencies
Mechanisms of epigenetic gene regulation by R-loops (HybReader)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The last decade has revolutionized our thinking about regulatory RNAs and yet we are still at the beginning of understanding their biology. One such challenge is presented by R-loops, prevalent DNA:RNA hybrids, which lie at the interface of different nuclear processes, including transcription, RNA processing, lncRNAs, DNA damage, chromatin, and neurodegenerative disease. Long-time considered a threat to genomic integrity, recent evidence indicates that certain R-loops can act as epigenetic gene regulators. The hypothesis is that nascent RNAs retained at their site of transcription may function as sequence-specific component of mammalian chromatin to shape gene expression. Notably, R-loops found at GC-enriched promoters are implicated in preventing DNA methylation and promote transcription, but how this might occur has remained obscure. In a breakthrough discovery, we identified the first epigenetic R-loop reader. This protein binds directly and specifically to DNA:RNA hybrids in vitro and in vivo, and mediates local DNA hydroxymethylation and demethylation via TET (Ten-Eleven Translocation) cytosine oxidases. Using the R-loop reader as a tool provides a unique entry point to address fundamental questions regarding mechanisms and regulation of the epigenetic function and biological role of these DNA:RNA hybrids. Applying genome-wide approaches and studying the biology of embryonic stem cells (ESCs), we will 1) systematically identify regulatory R-loops, 2) characterize their common features, 3) address how R-loops are decoded in ESC pluripotency and differentiation, 4) investigate how regulatory R-loops are erased, and (5) screen for additional R-loop binders/readers and characterize their epigenetic role. The HybReader project will allow for ground-breaking discoveries regarding the emerging epigenetic function and regulation of these poorly understood regulatory hybrids in the control of gene expression.
Solution Processed Next Generation Photovoltaics (Sol-Pro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Cyprus
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-06-30
Duration (months): 60.0
Total project cost (EUR): 1840940.0
EU funding (EUR): 1840940.0
Participants: 1
Project status: CLOSED

The profound advantages of printed photovoltaics (PVs), such as their light weight, mechanical flexibility in addition to the small energy demand, and low cost equipment requirements for roll-to-roll mass production, characterise them as a dominant candidate source for future electrical power. Over the last few years, the discovery of novel solution processed electronic materials and device structures boosted PV power conversion efficiency values. Despite that, power conversion efficiency is not a 'stand-alone' product development target for next generation PVs. Lifetime, cost, flexibility and non-toxicity have to be equally considered, regarding the technological progress of solution processed PVs. The ambit of the Sol-Pro research programme is to re-design solution processed PV components relevant to the above product development targets. Based on this, processing specifications as a function of the electronic material properties will be established and provide valuable input for flexible PV applications. Adjusting the material characteristics and device design is crucial to achieve the proposed high performance PV targets. As a consequence, a number of high-level objectives concerning processing/materials/electrodes/interfaces, relevant to product development targets of next generation solution processed PVs, are aimed for within the proposed ERC programme.

Keywords: printed electronics,flexible photovoltaics,solution processed opto electronic materials,research and product development,organic solar cells,electrodes,processing,devices
LV DC microgrids for evolved energy communities (DCNextEve)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Romania
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-10-15
Duration (months): 24.0
Total project cost (EUR): 137422.8
EU funding (EUR): 137422.8
Participants: 1
Project status: CLOSED

Microgrids are an important concept in the emerging power industry field. They are widely recognized as an innovative eco-system when it comes to a flexible and reliable option for the integration of distributed energy renewable resources (DER). The research on direct current (DC) power distribution systems is taking ground especially for applications where the end-use loads are natively DC (e.g. data centers, offices, residential). Efficiency, reliability, lower capital cost, simpler control strategies, higher power quality are the most cited advantages compared with AC microgrids. The primary technical research objective of this project is the design and analysis of novel methods for management and control of multiple building scale DC microgrids operating on a defined territory. Specifically the major technical objectives are: (a)To enhance the state of the art in the DC microgrid field with a holistic design, modelling, control framework for clusters of LV building level DC microgrids (the emerging community prosumers of tomorrow;) (b) To develop and validate models for typical elements of DC microgrids. The models will follow an innovative and yet unexplored approach based on hybrid dynamic system analysis; (c) To develop and test models for optimal operation of clusters of DC microgrids under uncertainty. The optimization models will look for different objectives to be optimized while taking into account the technical and economic constraints of the systems operating in either stand-alone or interconnected mode; (d) To develop and validate distributed control schemes for ad-hoc clusters of DC microgrids. Career development objectives are: (a) To enhance the research skills of the Fellow with complementary knowledge in power quality, modeling and control specific for DC grids, (b) To facilitate the transfer of knowledge to the society, scientific community and industry and to explore the commercial potential of the research outcomes.

Keywords: microgrids,dc power quality,sustainability,efficiency,optimization
SensUS: A non-invasive and quantitative ultrasound (QUS) device for an objective monitoring of the childbirth labour process. (SensUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Italy
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today the obstetrics sector is registering an increase in the C-Sections (CS) performed worldwide. Over 50% of CS are unnecessary, placing mother & baby under unnecessary risk. Unnecessary CS cause an extra cost of €750 million per year to the healthcare system in Europe. Although the WHO recommends not to exceed a rate of 15% of CS, Europe alone shows a rate of 29%. Most of the extra CS performed are due to errors during the monitoring of labour events. The few ultrasound devices available to monitor the labour timeline provide qualitative subjective information, depend on the operator skills, and some involve invasive procedures. Thus, new solutions are needed to help doctors take better informed decisions. In response to this need, we at AMOLAB have developed, patented and validated SensUS, a unique ultrasound device for quantitative & objective monitoring of childbirth events. This device contains our proprietary software, which measures selected validated parameters of the labour process. SensUS offers doctors objective details to support and guide their decisions during childbirth monitoring. In turn, it will allow to assign CS only to those cases that need it, reducing risks, costs and enhancing healthcare quality. After validating the reliability of SensUS on over 400 labours, we now want to take SensUS to market maturity. This project aims to finalise its technological development and secure its commercial aspects. To accomplish these goals, in Phase 1 we aim to evaluate the main milestones of the project from a technical, commercial and financial point of view, and prepare the most suitable strategy to achieve them. Once the project is completed and SensUS reaches the market, our technology will bring significant benefits to the obstetrics sector, as well as for the wellbeing of mothers and babies. In turn, AMOLAB will see its growth secured as a company, expecting to hire new 17 people and gain a Return of Investment of €4.69 from this project in 5 years.

Keywords: childbirth,labour,pregnacy,obstretrics,gynaecology,newborn,cesarean sections
A new hyperspectral radiometer integrated in automated networks of water and land bidirectional reflectance measurements for satellite validation (HYPERNETS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Research and Innovation actions
Countries involved: Estonia,Germany,Italy,Argentina,Belgium,France,United Kingdom
Call: Novel in-situ observation systems (H2020-SC5-2017-OneStageB, 2017)
Start date: 2018-02-01
End date: 2023-04-30
Duration (months): 63.0
Total project cost (EUR): 4999233.75
EU funding (EUR): 4999233.75
Participants: 10
Project status: SIGNED

Networking of automated instruments on unmanned platforms, e.g. AERONET-OC and RADCALNET, has proved to be the most effective way to provide validation data for Copernicus optical missions. The re-use of data from each site for many optical missions (S2, S3, PROBA-V,MODIS,VIIRS,L8,Pléiades,ENMAP,PRISMA,SABIAMAR,etc.) gives a huge economy of scale. The existing AERONET-OC and RADCALNET networks are based on multispectral instruments, which are expensive to acquire and require modelling associated uncertainties to cover all spectral bands of all sensors. Recent advances in opto-electronics facilitate the use of miniaturized hyperspectral spectrometers, with reduced price. Industrial production of video surveillance cameras greatly reduces the price of pointing systems for scientific instruments. Improved LEDs can provide a stable light source for relative calibration and continuous autonomous monitoring of radiometers. Webcams (for remote inspection of instruments and maintenance support) and data transmission have become cheaper allowing reducing the running costs and improving the reliability of autonomous instrument systems. The objective of the HYPERNETS project is to develop a new lower cost hyperspectral radiometer and associated pointing system and embedded calibration device for automated measurement of water and land bidirectional reflectance. The instrument will be tested in a prototype network covering a wide range of water and land types and operating conditions. Quality controlled data with associated uncertainty estimates will be provided automatically for the validation of all optical satellite missions. Preparations will be made a) for the new instrument design (and associated calibration service) to be commercialized with an expected lifetime of at least 10 years and b) for the networks to be further expanded to become the main source of surface reflectance validation data for all spectral bands of all optical missions for at least the next 10 years.

Keywords: copernicus validation,networks,optical remote sensing,hyperspectral,land and water,surface reflectance