Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation (TwinnToInfect)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: France,United Kingdom,Portugal
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 3
Project status: CLOSED

TwinnToInfect will provide IMM with the opportunity to integrate the European circle of research excellence institutions by cementing a sustainable science, technology and innovation network with two internationally-leading organisations in the immunity and infection area of research, the Institut Pasteur and the Francis Crick Institute. The strategy of TwinnToInfect, based on science- and innovation-driven clustering, is focused on this societal challenge that lies at the centre of many age-related disorders. TwinnToInfect will allow: i. strengthening the science and technology capacity of IMM in immunity and infection research field; ii. and leverage its research excellence and value creation through innovation with a beneficial and quantifiable impact for the entire research and development community at IMM, the Lisbon region and Portugal. The successful implementation of this strategy will rely on specific actions, including: 1) cementing of existing and the creation of new scientific, innovative and technical collaborations through short-term staff exchanges and short-term on-site training activities; 2) training, mentoring and international exposure of IMM’s young researchers and students; 3) building an innovation ecosystem centred at IMM; 4) igniting the entrepreneurial spirit among IMM’s research community; 5) increasing science awareness among the general public through targeted dissemination and communication activities; and 6) developing a sustainability strategy to sustain the cemented network beyond project terminus. Through the completion of these activities, IMM, supported by Pasteur and Crick, is in the best temporal and spatial position to achieve an improved capability to compete for internationally competitive research funding and to access business stakeholders. By claiming its position in research and innovation networks IMM will effectively contribute to research excellence and value creation in health at European level.

Keywords: immunity and infection,cementing european collaborations,research excellence,innovation potential,value creation,training and mentoring,smart specialisation strategy
Prioritisation and Risk Evaluation of Medicines in the EnviRonment (PREMIER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Germany,Italy,Germany,Spain,Germany,Finland,Sweden,Switzerland,Belgium,Sweden,Switzerland,France,France,United States,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Intelligent prediction and identification of environmental risks posed by human medicinal products (H2020-JTI-IMI2-2019-17-two-stage, 2019)
Start date: 2020-09-01
End date: 2026-08-31
Duration (months): 72.0
Total project cost (EUR): 10162029.65
EU funding (EUR): 4549999.65
Participants: 26
Project status: SIGNED

There are around 1900 active pharmaceutical ingredients (APIs) in use, yet the environmental risks of only a small proportion of these has been assessed. This calls for pragmatic science-based approaches for prioritising existing APIs in terms of their environmental risk. Such approaches could also be used pro-actively, i.e. to identify environmental concerns earlier in the drug development process, thereby contributing to a more sustainable future. The overall aim of PREMIER is to deliver an API information and assessment system for characterising the potential environmental risks of APIs, including relevant human metabolites and environmental transformation products, based on minimal testing. This system will be designed to screen and prioritise legacy APIs for tailored environmental assessment; identify potential environmental hazards associated with APIs in development; and to make the available environmental data more accessible for all stakeholders. The system will be optimized and validated using case studies on approximately 25 APIs. PREMIER will realize its aim by combining world-leading research on the environmental risks of APIs with the principles of co-design and smart knowledge-based IT. Through this combination, we want to be more than a conventional research project. We want to ensure that the results of our ground-breaking research “work” address all the societal concerns about the potential risks posed by the presence of pharmaceuticals in the environment.

Keywords: ecotoxicology,prioritisation,greener drug design,environmental risk assessment,degradation,sorption,target conservation,effects prediction,fish plasma model
Assessing cardiac Contractility and Quantification of Underlying mechanisms In vitro via Response in Excitation-contraction coupling (ACQUIRE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Academia and industry urgently needs reliable models to study heart failure and toxic effects of drugs on the heart. While new models based on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are now emerging, accurate readouts of cardiomyocyte function fall short of needs. Apart from improving the models biologically, more sensitive, informative and accurate readouts are needed to detect abnormal cardiomyocyte behaviour. Several tools have proven their ability to assess electrical changes or calcium handling in hiPSC-CMs, but they are typically incompatible with 3D tissue models and moreover, there is paucity of appropriate tools to quantify the most important function of myocardium: contraction. Our ERC Advanced Grant STEMCARDIOVASC entailed the development of improved tools for cardiac functionality. One of the most important bioassays developed as an outcome of STEMCARDIOVASC was the Triple Transient Measurement (TTM) System. The TTM System quantifies electrical activity, intracellular calcium flux and contractility simultaneously and is our answer to the challenge of pharma in understanding when and how drugs or diseases affect cardiac contractility using hiPSC-CM models. In this ERC Proof of Concept project “ACQUIRE”, we strive to bring the TTM to a commercial applicable service, and later product. To reach this goal we have set out four aims to come to a Minimum Viable Product: i) increase the flexibility of the system to accommodate a larger variety of optical probes, ii) increase the throughput of the system to compete with current measurement systems, iii) increase user friendliness by integrating software modules for running and analysing measurements and iv) define a route for commercialisation. Resulting from "ACQUIRE" the TTM System can be commercialized as a human cardiac based 3-in-1 assay for cardiotoxicity testing and a novel tool for providing mechanistic insight in the EC coupling for disease modelling and drug discovery.

Keywords: excitation contraction coupling,cardiac contractility,fluorescent imaging,drug testing,human induced pluripotent stem cells
European Training network Of PhD researchers on Innovative EMI analysis and power Applications: ETOPIA (ETOPIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Italy,Poland,Romania,Poland,Poland,Poland,Poland,United States,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-04-01
End date: 2023-09-30
Duration (months): 54.0
Total project cost (EUR): 3060300.96
EU funding (EUR): 3060300.96
Participants: 24
Project status: SIGNED

Our modern society becomes highly interconnected where power supply is not only providing energy between many distributed sources and loads but are also a main path of interference, especially in large complex systems, platforms and facilities, where interoperability of the electronic systems has to be achieved. There is an urgent need to train new researchers with a closer interaction of electrical power and power electronics with information technology and communications equipment. The ETOPIA consortium of key academic partners, supported by industry, has been brought together not only to train a sufficient number of qualified researchers but also to provide the fundamental research that underpins future technological developments. The detailed coordinated multidisciplinary multinational doctoral training program will provide the trainee researchers with a complete broad experience and at the same time allow them to develop and eventually lead their focused area of research. The program will focus on the development of novel methods to model, simulate, design, evaluate, measure and monitor. ETOPIA will also develop corrective economical measures for a safe, reliable, efficient and greener electrical power distribution system in and between buildings and vehicles. Specific innovations expected to be achieved through ETOPIA are methodologies to optimize the design of complex electrical/electronic installations with respect to compatibility and efficiency. Dissemination methods to realize optimal impact will include scientific publications, presentations and workshops, summer schools, training of engineers in industry and dissemination through newsletters, interviews, school visits, websites and social media.

Keywords: interference
Plants in search of water: physiological and molecular interplay between root hydraulics and architecture during drought stress (DROUGHTROOT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-15
End date: 2018-03-14
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Plants have to constantly adjust their water status during development and in response to very changing environmental conditions, recently increased by climate change. By exploring the soil and taking up water, plant roots play a crucial role in these processes. Drought exerts deep effects on root functions by altering root cell water permeability (hydraulics) and modulating the growth and architecture of the root system. Water channel proteins named aquaporins adjust root hydraulics in response to many stimuli, including drought stress. Auxin plays, together with abscisic acid (ABA), a pivotal role in root growth and development and regulates aquaporins during lateral root formation (LRF). The present project proposes a frame for integrating these effects by exploring functional links between root architecture, aquaporins and hydraulics, phytohormones, and modelling. Responses to water stress will be studied from the elementary level of LRF up to the whole root level to identify complex interactions and signalling pathways. The Arabidopsis root was chosen as a model for accelerated discovery, as it allows a unique combination of developmental biology, genomics, biophysics and mathematical modelling, with the purpose to transfer this knowledge to crops. This novel and multidisciplinary project will be carried out by a researcher with a strong scientific expertise on agriculture and plant molecular physiology which perfectly matches the proposed project. The latter will be implemented within a consolidated group and an internationally recognized institution (Aquaporin team, BPMP, CNRS/INRA/SupAgro/UM2 Montpellier, France). This combination provides a unique scientific platform for the research training of the applicant and the development of frontline research in plant science. The overall project will be strongly beneficial for the development of the applicant’s independent research career and will definitely strengthen his scientific profile.

Keywords: drought tolerance,hormonal interactions,root growth development,root hydraulics,aquaporins,plant water relations,mathematical modelling,plant molecular physiology
Animals and Plants in Cultural Productions about the Amazon River Basin (ECO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1999291.0
EU funding (EUR): 1999291.0
Participants: 1
Project status: SIGNED

Animals and plants feature prominently in cultural productions about the Amazon, testifying to the centrality of the region’s natural environment both for local populations and for the earth’s biosphere. The key hypothesis of ECO is that texts (broadly understood to include mythology, folk tales, the lyrics of songs, essays, literature, travel writings, etc.), cinema and art about this area highlight the ways in which non-human beings dynamically shape human cultural life. The project’s main challenge is to resort both to Amazonian thought and to the academic field of ecocriticism to assess how human cultural productions about Amazonia lend a voice to animals and plants. ECO develops the concept of zoophytography to describe the inscription of non-humans in texts, films and artworks, thus decentering humanity as the sole source of meaning-making. Research stream I. “Amazonian Zoophytography” formulates a definition of this notion and traces its roots to Indigenous and riverine epistemologies and to Western philosophy. Through archival research, ECO will then gather and analyze sources that portray Amazonian animals and plants from the beginning of the twentieth century onwards in two other research streams: II. “Animal Talk: Zoography Spelled Out” focuses on the articulation of animals in cultural productions about the Amazon; III. “Flora’s Voice: Phytographic Conversations” analyzes plant inscription in texts, cinema and artworks that question the role of vegetal life as a passive form of existence. ECO will make a significant contribution to the environmental humanities, offering an Amazonian perspective on ecocriticism, environmental philosophy and post-colonial studies. By creating a deeper understanding of conceptions of Amazonian fauna and flora, the project will reveal the interdependence of humans and non-humans, draw attention to environmental degradation in Amazonia and uncover more equitable views on animals and plants from the region.

Keywords: ecocriticism,environmental humanities,latin american studies,amazonian writings,cinema and art
KIOS Research Center of Excellence for Intelligent Systems and Networks (KIOS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Cyprus,United Kingdom
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 417000.0
EU funding (EUR): 417000.0
Participants: 2
Project status: CLOSED

The aim of the proposed TEAMING project is to develop the KIOS Research Center of Excellence for Intelligent Systems and Networks, an inspiring environment for conducting basic and applied research and innovation in the area of intelligent monitoring, management and security of critical infrastructure systems. The proposal is a team effort between the University of Cyprus and Imperial College London. The technical focus of the proposed Center of Excellence is a key technological area of significant growth potential. The strong background and individual experience of the University of Cyprus and Imperial College London in the area of intelligent monitoring, management and security, combined with the synergy created by the TEAMING proposal, provides a great opportunity for establishing a sustainable Center of Excellence, which will address crucial research and innovation problems of great societal benefit. The application of information and communication technologies (ICT) to critical infrastructure systems is completely aligned with the Cyprus Smart Specialization Strategy. The proposed Center of Excellence will create new job opportunities in the high-tech arena and will attract new researchers to Cyprus, thereby creating a sustainable critical mass of researchers that can address challenging scientific and technological problems. The TEAMING project will provide a significant boost towards the long-term sustainability of the Center through establishing long-term framework agreements with top academic institutions worldwide, via the generation of intellectual property rights and through the exploitation of the research results. Moreover, the proposed Center of Excellence will promote opportunities for collaboration between industry, academia and research organizations in technology areas of importance to Europe.

Keywords: intelligent control,computational intelligence,fault diagnosis,control engineering,smart infrastructure
Let's give the world appetite for health (ProteinPlus)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: France
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-09-01
End date: 2020-08-31
Duration (months): 48.0
Total project cost (EUR): 2449800.0
EU funding (EUR): 1714860.0
Participants: 1
Project status: TERMINATED

Disease-related malnutrition affects 33 million Europeans, a burden of 170bn€ for the EU. Oral Nutritional Supplements (ONS) are specially formulated foods designed to meet patients’ nutritional deficiencies during illness. This $10Bn ONS market is dominated by Nutricia, Nestlé, Fresenius & Abbott. However, large portion sizes and bad taste in ONS induce very low levels of treatment compliance (50%), dramatically limiting effectiveness. Manufacturers face a technological barrier that prevents them from increasing protein density and thus reducing volume. The aim of the project is to bring to the market a disruptive hyperproteinic ingredient – Protein Plus© - for ONS manufacturers, that overcomes this technology gap. Founded in 2004, EMULSAR invented and patented its Smart Emulsion Nanotechnology© (SENT©), used to manufacture disruptive ingredients for health and nutrition. Since 2012, SENT© has produced hundreds of tons of food ingredients (used by Casino, Unilever…to create healthier & tastier products), proving its industrial sustainability and compatibility with commercial food standards. In Phase 1, we proved (at lab-scale) that by applying SENT© to proteins, we can produce a protein-dense ingredient that makes it possible to reduce current ONS volumes by half. Our Phase 2 objectives are to optimize our Protein Plus© ingredient, validate the industrial process, establish clinical proof of improved ONS compliance & prepare our market launch. Our project will improve the competitiveness of ONS products, create public healthcare savings and enhance Europe’s health capital. For EMULSAR, the ONS market is the best path for becoming a European technology leader in health food, allowing EMULSAR to transition from nice-to-have applications (mass-market food) to must-have applications (medical nutrition). The current project is the key to reaching the full commercial potential of our nanotechnology, generating 75M€ in revenues & managing 120 employees by 2020.

Keywords: medical food,emulsion,industry,nutrition