Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Aneuploidy and Its Impact on Blood Development: Context Matters (CONTEXT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1999995.0
EU funding (EUR): 1999995.0
Participants: 1
Project status: SIGNED

Many childhood leukaemias start to develop before birth due to accumulation of mutations during foetal development. Children with trisomy of chromosome 21 (Ts21), also known as Down's Syndrome (DS), have a 500-fold increased chance of developing acute megakaryoblastic leukaemia. It is well known that aneuploidy (an abnormal number of chromosomes) is often associated with leukaemia and is likely to be driving this increased incidence of blood malignancies in children with DS. However, the mechanisms that control differentiation of haematopoietic stem and progenitor cells (HSPCs) and patterns of mutation acquisition in these cells during early human development are not well understood. This study will provide novel insights into two important questions: i) what is the impact of aneuploidy on blood formation in the context of specific tissue and ii) how it affects mutation accumulation and clonal selection in HSPCs. Here I aim to reveal cellular and mutational processes active during human Ts21 foetal blood development by: 1) performing comprehensive single-cell transcriptomics and spatial transcriptomics analysis of human Ts21 and healthy foetal liver and bone marrow combined with single-cell in vitro differentiation assays and 2) generating a catalogue of all somatically-acquired mutations in hundreds of Ts21 foetal haematopoietic progenitors using whole genome sequencing. The approach I propose derives its power from the close integration of state-of-the-art experimental data generation and computational analysis using novel methods. By examining cell intrinsic vs extrinsic processes in Ts21 haematopoiesis as well as mutation accumulation in individual stem cells this study will provide unprecedented insight into the mechanisms by which cellular changes induced by aneuploidy affect and possibly drive leukaemia. A better understanding of early events in human development, in health and disease, will open new routes for diagnosing, monitoring and treating disease.

Keywords: human foetal haematopoiesis,blood stem cells,single cell transcriptomics,spatial transciptomics,aneuploidy
RETROFIT SOLUTIONS TO ACHIEVE 55% GHG REDUCTION BY 2030 (RETROFIT55)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Italy,Spain,United Kingdom,Finland,Germany,Greece,Liberia,Ireland
Call: Transformation of the existing fleet towards greener operations through retrofitting (ZEWT Partnership) (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 5650300.0
EU funding (EUR): 4109030.0
Participants: 16
Project status: SIGNED

The proposal develops a combination of energy-saving solutions that can be adopted in retrofitting aimed at achieving the 35% of GHG emissions. Two new technologies, i.e. wind assisted ship propulsion and an innovative air lubrication system, will be developed together with other solutions that, although based on already mature technologies, such as operational and hydrodynamic design optimization and ship electrification, have to be expanded to be integrated with the new solutions as well as to cope with the constraints posed by the original ship design. The final objective of RETROFIT55 is to create an advanced web-based Decision Support System (DSS), that fuses together digital twins of the different systems into an integrated digital ship model. The DSS will feature a catalogue of retrofitting solutions that are up-to-date and ready to be deployed at the end of the project and easily extendable afterward while developed and demonstrated at TRL 7-8, suitable for different ship types and operational contexts. The DSS will enable the user to configure the retrofitting by combining different options which are suitable for the specific ship type and comparing them in terms of life-cycle cost, return-of-investment and several KPIs, such as EEXI, CII. Referring to the ZEWT strategy, while primarily contributing to the Design and Retrofit, the implementation of the project will also intersect other topics, such as Use of Sustainable Alternative fuels, Energy Efficiency, Electrification and Digital Green. The consortium brings together universities and research institutions, three developers of the new technologies, a ship design office, software developers, ICT experts, a classification society, a ship-repair company, and two large ship operators.

Keywords: emission reduction decision support system operational optimization ship electrification,retrofitting,energy efficiency,friction reduction,air lubrication,wind assisted propulsion
MountBuzz: relating context-dependent bee-flower interactions to macroevolution (MountBuzz)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1498634.0
EU funding (EUR): 1498634.0
Participants: 1
Project status: SIGNED

Adaptive evolution of flowers to optimize pollen transfer by animal pollinators is considered a key driver of plant speciation and the success of flowering plants. Plant-pollinator interactions are embedded in complex abiotic (climatic) and biotic (other plants/pollinators) contexts, and the structure and function of interaction networks changes across such contexts. To date, however, we lack a broad-scale perspective on how these contexts affect which flower phenotypes are ‘fit’, and how flowers evolve to adapt to these contexts. This knowledge gap limits our understanding of the processes that generate and maintain biodiversity, critically important in light of current global change. In MountBuzz, I aim at developing a novel context-dependent ecological perspective on the processes structuring the evolution of flower diversity by linking the commonly separated fields of community ecology and macroevolutionary modelling. First, to determine which flower phenotypes are ‘fit’ (high reproductive success) in different a-/biotic environmental contexts, my team and I will analyze plant-pollinator interactions and flower and pollinator trait data along four elevational gradients across the tropics. We will combine empirical field observations with pollination experiments to pinpoint context-dependent changes in phenotype-fitness relationships. Second, synthesizing across these results, we will test whether patterns of flower macroevolution follow predictable, context-dependent trajectories by employing machine-learning based predictive modelling and phylogenetic comparative methods. The results of MountBuzz will deliver a new perspective on the relative importance of pollinator-mediated selection and environment-dependent processes in driving flower evolution and plant diversification. My study set-up (cross-continental, cross-environmental, cross-lineages) further allows for identifying generalities in patterns, thereby delivering novel hypotheses for future research.

Keywords: plant pollinator interactions elevational gradients tropics melastomataceae trait matching competition reproductive strategies fitness bipartite networks buzz pollination flower morphology community phylogenetics phylogenetic comparative methods
PAncreatic Cancer therapeutic discovery using Monoclonal ANtibodies (PACMAN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The PACMAN project aims to develop a novel therapeutic approach for treating pancreatic ductal adenocarcinomas (PDAC), one of the deadliest cancers with limited therapeutic options. The project focuses on targeting an overexpressed cell surface protein in PDAC implicated in tumor proliferation, invasion and migration by driving carcinogenic signaling. This study aims to investigate the ability of a highly specific monoclonal antibody targeting this protein to treat PDAC. By studying the therapeutic efficacy and unravelling associated biomarkers of treatment response in patient-derived PDAC models, the PACMAN program will provide preclinical proof of concept to treat PDAC with a novel class of monoclonal antibodies. Based on a robust patient-derived data package, this innovative approach provides the perspective for a first-in-class therapy for PDAC, addressing a critical unmet medical need and offering new hope for patients with this aggressive cancer.
Who Has Eaten the Planet? The paths of food systems beyond the safe and just operating space (1850-2020) (WHEP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Spain,Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1494166.0
EU funding (EUR): 1494166.0
Participants: 3
Project status: SIGNED

Food production covers the most basic human need, and simultaneously is the main driver of anthropogenic environmental impacts. These impacts have resulted in the transgression, during the brief period since the industrial revolution, of the planetary boundaries defining the safe operating space of humanity. A rich research literature quantifies the last 60 years’ fast, heterogeneous, and often unfair development in food supply and related environmental impacts, and how these depend on agro-climatic factors, technology, and trade flows, all of which have greatly changed but with different trajectories around the world. However, these developments lack an integrated approach, and are very poorly quantified before 1961. WHEP will bridge these knowledge gaps, assessing “who has eaten the planet” by answering the questions: “What are the environmental impacts of food production since 1850?”, “What is the role of trade in food supply and in displacing the responsibilities for these impacts?” “How are impacts related to planetary boundaries, food supply and inequality?” These highly ambitious goals are addressed by four objectives: 1) Constructing a consolidated global country-level annual database on agricultural production and management, using massive data collation in combination with modelling; 2) Estimating the environmental impacts: greenhouse gas emissions and carbon, land, water, nitrogen, and phosphorus through spatially explicit, integrated, dynamic modelling; 3) Calculating product footprints and tracing them along international trade chains; and 4) Analyzing the observed trajectories in the safe and just operating space, by assessing the drivers, and how impacts at the production and consumption levels are related to fair and healthy supply. This ground-breaking research will shed new light on the environmental history of food, opening up many new research frontiers, and providing necessary information to design fair and sustainable policies.

Keywords: planetary boundaries,diets,agro food system,land use change,greenhouse gas emissions,soil organic carbon,nitrogen,phosphorus,water,long term,life cycle assessment,environmental footprints,integrated modelling
Renewable Energy Site Selection using Artificial Intelligence and Geographic Information System (RESSAIG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 1
Project status: SIGNED

The RESSAIG project (Renewable Energy Site Selection using Artificial Intelligence and Geographic Information System) aims to enhance the identification and development of sites for clean renewable energy sources, such as photovoltaic (PV) arrays and both onshore and offshore wind farms. Utilizing a blend of Artificial Intelligence (AI), deep learning, remote sensing data, Geographic Information Systems (GIS), and government datasets, the project seeks to optimize site selection for renewable energy and water desalination necessary for hydrogen production. Amidst the global shift towards sustainable energy solutions to combat climate change, there is an urgent need for more efficient and precise methods for identifying optimal sites for renewable energy installations. Traditional methods often overlook critical environmental, economic, and social factors that RESSAIG's integrative approach will consider, thus ensuring more sustainable and economically viable energy production. The urgency for sustainable and low-carbon energy solutions is accentuated by increasing environmental concerns and international commitments to reduce carbon footprints. RESSAIG's advanced mapping technologies come at a crucial time to meet the growing demand for renewable energy infrastructure and support the transition towards green hydrogen as a key energy carrier for the future. Our team brings together leading experts in AI, GIS, remote sensing, and renewable energy, uniquely positioning us to tackle this complex challenge. Our interdisciplinary approach combines cutting-edge technology with extensive field knowledge, enabling us to provide innovative solutions that are both scientifically rigorous and practically applicable. RESSAIG enhances renewable energy site selection, reducing costs and driving investment through detailed cartographies and economic analyses, fostering informed decisions and promoting sustainability, economic growth, and job creation.

Keywords: renewable energy,site selection,geographic information system,remote sensing,multicriteria decision analysis,
QED factorization for eXclusive semi-leptonic B-meson decays (QED4X)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 226629.12
EU funding (EUR): 226629.12
Participants: 1
Project status: SIGNED

Exclusive semi-leptonic B decays provide an important laboratory for measuring fundamental parameters of the Standard Model (SM), or to search for yet unknown particles and interactions. Various tensions between experimental measurements and SM predictions have been guiding the theoretical efforts over the past years. To draw reliable conclusions from the anticipated experimental high-precision data for such decays in the coming years, requires a rigorous study of sub-leading corrections that have been neglected so far. With the proposed action, the researcher aims to investigate the impact of so-called structure-dependent electromagnetic corrections to kinematic distributions in semi-leptonic B decays, using modern Effective Field Theory and factorization methods. A systematic study of QED corrections along these lines is a relatively new field of research, and in certain cases revealed surprising enhancement mechanisms not captured in a pointlike-meson description. An analysis of these effects in semi-leptonic transitions at the differential level is ambitious, and phenomenologically interesting. Photon couplings between the charged leptons and the meson constituents might lead to enhanced effects in rates or angular distributions. Uncertainties from novel hadronic parameters must be added to ‘clean’ ratios with reduced hadronic uncertainties. Conceptually, factorization is achieved using of Soft-Collinear Effective Theory and Heavy-Quark Effective Theory. The analysis of these decay amplitudes require modern sub-leading power techniques to deal with technical difficulties such as endpoint singularities. The action is subdivided into four work-packages (WP): Factorization theorems for charged and neutral-current semi-leptonic transitions are derived in WP1 and WP2, respectively. Novel concepts regarding the treatment of endpoint-singularities are developed in WP3, and WP4 aims at a collinear-photon inclusive 'jet-like' treatment of electronic channels.

Keywords: effective field theories,factorization,flavour physics,qed corrections,precision predictions,phenomenology of b decays
YOUth Debunking the gendered Arguments of far-Right Extremism (YOU-DARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: France,Denmark,Italy,United Kingdom,Sweden,Spain,Hungary,Romania,Switzerland
Call: Gender-roles in extremist movements and their impact on democracy (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 2999642.5
EU funding (EUR): 2999642.5
Participants: 11
Project status: SIGNED

YOU-DARE advances an interdisciplinary programme to study and intervene on the gender constructions of far-right youth groups and leaders, and their normalisation in the mainstream, across 8 countries (DK, ES, UK, FR, HU, IT, RO, SE). The project innovates on the current state of the art in four ways. First, we challenge existing oversimplifications of far-right ideas on gender, and adopt an intersectional lens exposing their contradictions and complexities where anti-gender hyper-masculine/feminine tropes go alongside pro-gender equality endorsements within anti-immigration campaigns. Second, we concentrate on the youth which is an under-studied group within research on the far-right, and explore the importance of gender for this demographic as a key avenue of identity formation and politicisation. Third, we focus on far-right youth formal leaders at local levels, and new types of leadership such as online influencers. Four, we offer a thorough understanding of how far-right youth ideas on gender impact on democracy by charting how they inform policy debates and become normalised. YOU-DARE will also produce methodological and policy innovation (a) by using qualitative methods to investigate far-right youth leadership; (b) mapping online ‘gender controversies’ engaging far-right youth; (d) overcoming methodological nationalism through a focus on local levels and the creation of a transnational network of researchers, activists and stakeholders and (c) conducting crosscutting comparative analyses across the 8 countries and selected localities. Finally, to maximise impact, YOU-DARE establishes a Policy Lab as a collaborative platform for policy design, recommendation and implementation. Implementation of policy recommendations generated by the project will be sought through the funding of local level pilot-tested solutions seeking to minimise the appeal of far-right ideas on gender among the youth, and thus reduce their impact on democratic values and practices.

Keywords: far right youth masculinity leadership influencers gender controversies normalisation of far right ideas policies,countering extremisms
Development and evaluation of nutritional strategies to reduce and prevent obesity in shift workers (SHIFT2HEALTH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Austria,Netherlands,Germany,Italy,Poland,Denmark,Belgium
Call: Prevention of obesity throughout the life course (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 9962573.75
EU funding (EUR): 9962573.75
Participants: 15
Project status: SIGNED

Shift work is an independent risk factor for the development of overweight and obesity. As shift workers represent a huge target group throughout many sectors in Europe obesity and associated diseases stress national health systems. Unhealthy food choices (snacking, high sugar intake, preferences for spicy and sweet-fatty foods) were reported for this group, which are likely the main causes for becoming obese. The underlying mechanisms for these changed eating patterns remain to be resolved. Potential explanations are alterations in metabolic health conditions (e.g. microbiome and inflammation), taste perception and circadian misalignment. Empirically proven solutions are urgently needed to benefit national health systems and reduce the development of obesity and increase the wellbeing of shift workers in the EU. This project aims to identify mechanisms and environmental and lifestyle factors leading to obesity in shift workers and to develop and evaluate products and strategies with consideration of the behavioural and relational level to support healthy eating patterns. The project will focus on both healthcare (female dominated) and industrial workers (male dominated), two major sectors where working in shifts is common. We will combine existing and new knowledge on nutritional, behavioural, perceptual and physiological determinants of (un)healthy food choices in a cross-section trial and consider personal needs and wishes. Based on the latter results, promising strategies, technical solutions and products will be developed and tested within the target group in specific interventions. During all steps, stakeholders (health work organisations, shift workers` representatives, companies, policy makers and scientists) will be involved. With the results, new insights in the nutrition-related mechanisms involved in the development of obesity among shift workers will be identified and tailored strategies benefitting shift workers and employers will be developed.

Keywords: obesity prevention,shift work,nutrition,behavior,food choice and preferences,sensory perception,microbiome,biomarker,circadian misalignment,strategy development,personal needs,digital tool