Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evaluation of a production ready portable, Point-of-Need Platform (instrument and reagents), direct from nasal swab test for the molecular diagnostic detection of COVID-19 infection. (KRONO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Italy,France,France,United Kingdom
Call: Development of therapeutics and diagnostics combatting coronavirus infections (H2020-JTI-IMI2-2020-21-single-stage, 2020)
Start date: 2020-09-01
End date: 2022-06-30
Duration (months): 22.0
Total project cost (EUR): 1819963.75
EU funding (EUR): 784470.0
Participants: 5
Project status: SIGNED

This project focuses on rapid (40min), simple, Point-of-Need COVID-19 testing, e.g. surgery/home (via first responders)/transit points of entry. BG Research (BGR) has developed direct from crude sample detection of viral pathogens – the QuRapID-XF technology, removing requirement for nucleic acid extraction, expert users or a laboratory; results delivered while you wait. Tests utilise the Gold Standard polymerase chain technology as current clinical reference tests, but using our novel reagent, directly breaking open the virus and a single enzyme system that is resistant to the inhibitory compounds found in crude biological samples. Objectives: 1. Develop a lyophilised assay for direct detection of SARS-CoV-2 from nasal swab samples. 1. Production scaling of a portable instrument for performing the test at Point-of-Need. 2. Demonstration of a pipeline for rapidly deploying new assays in response to future outbreaks and detection from a wider range of sample types. 3. Validation of the assay at 3 independent sites using clinical samples, generating data sets for regulatory approval. Achieving the objectives: BGR has pre-production portable systems in testing for the in-field detection of veterinary diseases from animal nasal swabs. This project will bring scaled production of the product forward by minimally 3 months together with a validated lyophilised SARS-CoV-2 assay. The team has proven experience in diagnostics design and development and will have access to clinical patient samples from Italy and France, generating quantified standards and performance evaluation data that BG Research will document under its ISO13485 quality standard and generate data for EUA regulatory approval. Relevance to Work P: The IMI2 call is seeking innovative diagnostics to have impact in combating the current Coronavirus outbreak and this proposal to provide rapid and simplified differential diagnostics at the point of need, is directly aligned with the scope.

Keywords: point of need,molecular diagnostics,rt qpcr,sars cov 2,portable,covid 19,rapid diagnostics,simple diagnostics,multiplex diagnostics,pan flu,sars,mers,virus x
PROMOTioN - Progress on Meshed HVDC Offshore Transmission Networks (PROMOTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Germany,Germany,Germany,Spain,Ireland,Italy,Germany,Belgium,Belgium,Sweden,Switzerland,Norway,Norway,Norway,Sweden,France,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,Denmark,United Kingdom,United Kingdom,Denmark,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Innovation and technologies for the deployment of meshed off-shore grids (H2020-LCE-2015-3, 2015)
Start date: 2016-01-01
End date: 2020-09-30
Duration (months): 57.0
Total project cost (EUR): 42691662.81
EU funding (EUR): 34480931.6
Participants: 52
Project status: CLOSED

In order to unlock the full potential of Europe’s offshore resources, network infrastructure is urgently required, linking off-shore wind parks and on-shore grids in different countries. HVDC technology is envisaged but the deployment of meshed HVDC offshore grids is currently hindered by the high cost of converter technology, lack of experience with protection systems and fault clearance components and immature international regulations and financial instruments. PROMOTioN will overcome these barriers by development and demonstration of three key technologies, a regulatory and financial framework and an offshore grid deployment plan for 2020 and beyond. A first key technology is presented by Diode Rectifier offshore converter. This concept is ground breaking as it challenges the need for complex, bulky and expensive converters, reducing significantly investment and maintenance cost and increasing availability. A fully rated compact diode rectifier converter will be connected to an existing wind farm. The second key technology is an HVDC grid protection system which will be developed and demonstrated utilising multi-vendor methods within the full scale Multi-Terminal Test Environment. The multi-vendor approach will allow DC grid protection to become a “plug-and-play” solution. The third technology pathway will first time demonstrate performance of existing HVDC circuit breaker prototypes to provide confidence and demonstrate technology readiness of this crucial network component. The additional pathway will develop the international regulatory and financial framework, essential for funding, deployment and operation of meshed offshore HVDC grids. With 35 partners PROMOTioN is ambitious in its scope and advances crucial HVDC grid technologies from medium to high TRL. Consortium includes all major HVDC and wind turbine manufacturers, TSO’s linked to the North Sea, offshore wind developers, leading academia and consulting companies.

Keywords: hvdc,offshore,wind power,north sea,transmission systems,circuit breakers,protection systems,diode rectifier converter,meshed hvdc grid,grid regulation,financing of infrastructure
Public Space Navigation for All (PAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Germany,United Kingdom
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

PAL aims to perform a feasibility study and elaborate a business plan testing out the innovative idea of making public spaces accessible for All. The PAL idea is simple: provide an indoor navigation service similar to what we are used to when driving. The project focuses on users with specific needs especially elderly and visually impaired persons who need to find their way through complex travel hubs and train stations. Although the idea is simple, its implementation is quite challenging. There are numerous technologies involved (indoor localisation, mapping, routing, information presentation) which have to be mastered. Fortunately, in PAL we base on technology the partners have developed in previous projects, notably MOBILITY funded by the German Ministry for Education and Research, and successfully tested at the Frankfurt airport. PAL will assess the technological viability, the application boundaries, the value added, the business model, and the economic viability of this MOBILITY solution with a single focused aim to work out a credible, realistic and achievable business plan. IN2 and SPRING, the partners in this endeavor, have successfully collaborated in the past in MOBILITY, own its project results and are fully committed to bring them to the market.

Keywords: accessibility,persons with special needs,navigation in travel hubs
How does the Earth stop global warming? Using metal isotopes to understand climate recovery processes (EnvironMetal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-05-17
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Earth’s history is punctuated by climate disturbances, often marked by abrupt changes in the carbon cycle, and by mass-extinctions. Episodes of rapid, large-scale carbon release are linked to global warming events that last for 100,000s years. Warming is accompanied by ocean acidification and widespread oceanic anoxia representing a combination of environmental threats that we increasingly face today. It is less well appreciated that these processes form a continuum of feedback mechanisms that eventually remove carbon from the atmosphere and re-stabilise the climate. However, the precise operation of this complex climate recovery process is poorly understood and the role of each feedback mechanism is hotly debated. An accurate understanding of these feedbacks in the past is crucial to defining scenarios of anthropogenic climate change and understanding the boundary conditions for a habitable planet. To fully understand this complexity, a detailed description of each individual carbon removal process is required. This project will provide the first systematic separation of parallel feedback mechanisms using a suite of metal isotope proxies in marine sediments, combined with a quantiative biogeochemical modeling approach. These tools will be applied to a number of past warming events to characterize the climate recovery process

Keywords: climate recovery,carbon sequestration,anoxia,weathering,acidification
Early conditions, delayed adult effects and morbidity, disability and mortality in modern human populations (ECHO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 2852655.0
EU funding (EUR): 2852655.0
Participants: 1
Project status: SIGNED

This project aims to reformulate and generalize standard theories of human health and mortality. It proposes new formal models and a systematic agenda to empirically test hypotheses that link developmental biology, epigenetics and adult human illness, disability and mortality. We seek to break new ground developing innovative formal models for illnesses and mortality, testing new hypotheses about the evolution of human health and, to the extent permitted by findings, reformulating standard theories to make them applicable to a less restrictive segment of populations than they are now. Over the past two decades there has been massive growth of research on the nature of delayed adult effects of conditions experienced in early life. This field of research is known as the Developmental Origins of Adult Health and Disease (DOHaD). Increasing evidence suggests that the mechanisms that are implicated are epigenetic and constitute an evolved adaptation selected over thousands of years to improve fitness in changing landscapes. The emergence of DOHaD is as close as we will ever come to a paradigmatic shift in the study of human health, disability and mortality. The most tantalizing possibility is that advances in our understanding of epigenetic mechanisms will shed light on pathways linking early exposures and delayed adult health thus fundamentally transforming our understanding of human illnesses and, in one fell swoop, bridge population health, epigenetics, and developmental and evolutionary biology. The overarching goal of this project is to contribute to this nascent area of study by (a) proposing new formal demographic models of health, disability and mortality; (b) empirically testing DOHaD predictions with population data; (c) testing a microsimulation model to verify DOHaD predictions about two conditions, obesity and Type 2 Diabetes, and (d) assessing the adult health, disability and mortality toll implicated by relations between early conditions, obesity and T2D.

Keywords: dohad,epigenetics,obesity,mortality,multistate models,formal demographic models,microsimulation models
Controlling mIcRobiomes CircuLations for bEtter food Systems (CIRCLES)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Italy,Italy,Italy,Italy,Italy,Italy,Spain,Ireland,Italy,Italy,Italy,Belgium,Greece,Switzerland,Norway,Norway,Finland,Finland,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,Luxembourg,Portugal
Call: Microbiome applications for sustainable food systems (H2020-SFS-2018-1, 2018)
Start date: 2018-11-01
End date: 2024-10-31
Duration (months): 72.0
Total project cost (EUR): 11096080.18
EU funding (EUR): 9999964.879999999
Participants: 34
Project status: SIGNED

CIRCLES aims to discover and translate innovative microbiomes-tailored circular actions into concrete applications that will ultimately enhance EU food system performances and their overall sustainability. The setup of real-world labs in the field of 6 food systems relevant to the EU market – tomatoes, spinach, poultry, pigs, Atlantic salmon and seabream aquacultures – will, first, enable CIRCLES to increase knowledge on the importance of food system microbiomes as determinants of productivity, quality, safety and sustainability. This discovery phase will nurture the design and implementation of food system-specific microbiomes-tailored circular actions. Relying on an integrative usage of different Smart Microbiome (SM)-modulators, circular actions aim to optimize the microbiomes of food systems, from farm to fork, for an overall improvement of food system performances. The effectiveness of actions will then be tested in the labs in the field. This real-world validation phase will allow CIRCLES to translate the project results into concrete products, applications, procedures and tools, ready to be exploited and communicated to penetrate the EU market. In particular, CIRCLES will conceptualize and create SM-food systems for the 6 CIRCLES food chains, defined as food systems with optimized microbiome configurations. CIRCLES will also provide innovative, newly defined SM-food products, as foods derived from the SM-food systems and certified by Microbiome Transparent (MT)-labels. Finally, a vast panel of food system-specific SM-modulators will be provided as new agro-biotech applications to be integrated into circular actions to reach the status of SM-food system. In conclusion, the conceptualization, creation, and dissemination of SM-food systems, as well as all connected procedures, products, and tools, will allow CIRCLES to endow the EU food systems with new, cost-effective commercial applications for improved productivity, quality, safety and sustainability.

Keywords: microbiomes,knowledge,food systems,foods,productivity,quality,safety,sustainability,market,awareness
Turning oil into stone: Oil legacies in the narratives of urban continuity and change in Baku, Azerbaijan (BAKOIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-14
End date: 2023-08-27
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

This research project will explore the construction of ‘oil city’ narratives in Baku, Azerbaijan. Baku is one of the earliest and historically most significant oil cities in the world. Despite this important legacy, there has been little scholarly attention to the ideological and cultural meanings of oil in different urban milieus. Addressing this gap in scholarship, this study aims to deepen scholarly understanding of the constitution of oil urbanism and its implications for post-oil future. The development of many cities that are linked to oil production is dependent upon the economic cycles of boom and busts of the industry. Typically, oil cities rapidly grow during a boom, and decline during a bust. Few cities are able to reinvent themselves after a bust, either by diversifying their economies or assuming the role of a technological hub for the industry. Baku is unusual among the world's oil cities, as it neither declined nor reinvented itself, but has perpetuated its dependence on oil for the last 150 years and continued to strengthen its identity as ‘the oil city’. Using a combination of ethnography and textual analysis, this study aims to provide a detailed ethnographic analysis of how Baku’s oil city identity has been constructed and reproduced in official and unofficial discourses by variously positioned professionals involved in memory-making, either directly (museum workers and urban heritage activists) or indirectly (oil industry professionals; city planners; tour guides). The main research objectives are: 1) to examine the official and unofficial narratives of urban continuity based on oil production in their socio-cultural context 2) to explore the practices of collective remembering and forgetting in constructing the narratives of Baku as a historical center of oil production and 3) to explore how an urban identity based on oil affects the imagination of a post-oil future among these groups.

Keywords: oil urbanism,boom and bust,urban memory,tourism
Mass cytometry nanotools for intracellular target engagement. Towards precision medicine. (TARGETOF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Cancer is the second highest cause of death in Europe and one of the biggest challenges facing humanity. The discovery of multi-kinase inhibitors has emerged as a strong alternative treatment for many cancers. However, the appearance of severe side effects due to their intrinsic target promiscuity limits the dosage and efficiency of these treatments. Therefore the characterisation of this promiscuity is crucial to develop selective and safe treatments. We propose a versatile and efficient approach to detect the binding of a given drug to target proteins. Combining intracellular target engagement devices based on nanotechnology with the state-of-the-art mass cytometry techniques, this approach will allow one-step target engagement profiling, and thus will streamline the discovery of the mode-of-action of a given drug. Furthermore, the development of an intracellular barcoding system in combination with the multiplexing capacities of mass cytometry will allow for the combination of multiple cell types in one single experiment, further accelerating the target deconvolution process. This research will greatly contribute to the development of a straightforward method to detect the most expressed targets in patient biopsies, and to select the best therapy for a given patient. This fellowship will consolidate me as an independent researcher, providing me with the opportunity for many cross-disciplinary collaborations, and to establish myself as an expert in the field of precision medicine.

Keywords: mass cytometry
The Ethics of Oil: Finance Moralities and Environmental Politics in the Global Oil Economy (ENERGY ETHICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 1498052.0
EU funding (EUR): 1498052.0
Participants: 1
Project status: SIGNED

In October 2014, the Chairman of the Bank of England Mark Carney warned that many oil reserves cannot be developed. If so, they would contribute so significantly to increased greenhouse gas emissions that international targets to avoid dangerous levels of global warming would be exceeded. However, stock valuations of oil companies assume that all proven and probable reserves can indeed be produced. Amounting to a potentially enormous debt overhang, the Bank of England has launched an enquiry into the threat of a crisis similar to the subprime mortgage crash, known as the ‘carbon bubble’. This looming crisis with its ‘stranded assets’ raises urgent questions about the conflicting dynamics between finance moralities and environmental politics at a time of oil dependency and an uncertain climate future. Grounded in ethnographic fieldwork with oil companies in the US and Norway, energy analysts in the UK and the US, and fossil fuel divestment movements in Germany and the UK, ENERGY ETHICS will develop a new framework for understanding the relationship between oil, money and climate change that counters the prevalent tendency to interpret these issues through aggregated normative systemic analysis only. Taking its starting point in people’s own perceptions of and direct involvement in the oil economy, it will offer a major step forward in understanding how people in positions of influence within the oil economy make financial and ethical valuations of oil. This will contribute to public stakeholder dialogue and wider transdisciplinary engagements. Focusing on oil and its financialization, ENERGY ETHICS has three main research objectives: 1) to examine how people positioned strategically in relation to the global production of oil conceptualise and influence the oil market; 2) to understand the linkages and frictions between these different valuations of oil; and 3) to investigate how oil valuations relate to political reforms and new climate economic initiatives.