Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
3D image-based search engine and triaging software for lung CTs to improve radiology workflows (Contextflow)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 1722675.0
EU funding (EUR): 1205872.5
Participants: 1
Project status: CLOSED

Radiology is struggling. Exponentially increasing quantities of data make it difficult to index and search for relevant information when it's needed most. Radiologists' workload is also rapidly increasing, exacerbated by the global radiologist shortage. What's more, new treatments require more complex diagnoses. When faced with a difficult case, radiologists must currently wait to discuss with colleagues, consult reference books or guess search terms in text-based resources. This frustrating, time-consuming process leads to delays, missed findings and high overtime expense. contextflow develops deep learning-based tools to improve radiology workflows, saving time while increasing reporting quality. SEARCH is a 3D image-based search engine designed to help reduce search time for difficult cases. Lung diseases are particularly hard to diagnose; they are characterised by the combination and distribution of 40 anomalous patterns observed in lung CTs. SEARCH can already detect 19 disease patterns (competitors only 1-3), instantly linking a 3D image to reference cases with similar findings, case statistics and reference information necessary for differential diagnosis. TRIAGE is a separate tool that automatically detects disease patterns in scans so that doctors quickly identify time-critical patients. contextflow aims to reduce the time radiologists spend searching for information, allowing for both faster and higher-quality diagnostics. The EIC project will complete the remaining technical and business development activities before product launch: developing methods to detect lung diseases based on the anomalous lung disease patterns already detected by the software; and identifying signatures indicative of diseases in medical data to support personalised treatment decisions. As the coronavirus (COVID-19) is characterised by distributions of anomalous patterns that contextflow already detects, developing disease detection for COVID-19 infections is a high priority.
Identifying and deciphering the mechanism of the cellular machinery responsible for disaggregation of intracellular prion-like Tau aggregates (REVERSING TAUOPATHY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Tauopathies are a group of neurodegenerative diseases, the most common of them being Alzheimer’s disease, which are associated with the aggregation of protein Tau in the brain. Despite major research efforts world-wide, the mechanism of Tau aggregation and its pathogenesis giving rise to such neurodegenerative diseases is not yet understood. Therapeutics to cure these tauopathies, including Alzheimer’s disease, are urgently needed. We aim to identify the conditions, the cellular machinery responsible and the mechanism of disaggregation of intracellular prion-like Tau aggregates in HEK293 cell lines, with one condition already been identified (starvation). For identifying the conditions of disaggregation, high resolution confocal microscopy will be used for visualizing intracellular Tau aggregates tagged with yellow fluorescence protein (YFP). For deciphering the cellular components responsible for disaggregation, the proteins associated with the aggregates will be identified using quantitative mass spectrometry from SILAC (stable isotope labeling with amino acids in cell culture) labeled cells. Moreover, candidate factors will be downregulated by siRNA to establish their involvement in aggregate disassembly. Such components individually and in combination will then be analyzed for their disaggregation activity in vitro using filter trap assay for the quantification of disaggregation. Cryo-electron tomography of Tau aggregates under various conditions (e.g. during disaggregation) will be carried out in collaboration with Prof. Wolfgang Baumeister (MPIB). Besides contributing to the benefit of humankind, the proposed research work on neurodegenerative diseases will allow me to grow as a researcher and will help me in realizing my true potential as a scientist. The MPIB and the Hartl lab in particular will play an important role in this regard due the availability of state-of-the-art research facilities and an intellectually stimulating environment.

Keywords: alzheimer s disease,tauopathies,dementia,prion,protein aggregation,disaggregation,proteostasis,cellular stress,heat shock,chaperones
Mechanisms of electroreception in bees and other terrestrial animals (ElectroBee)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2024-02-29
Duration (months): 78.0
Total project cost (EUR): 2294320.0
EU funding (EUR): 2294320.0
Participants: 1
Project status: SIGNED

Many animal species can detect the electric fields in their environment. Electroreception has mainly been studied in aquatic vertebrates; fish like sharks and rays, gymnotid and mormirid electric fish, the lamprey, the platypus, the coelacanth, and one mammalian species, a dolphin. We have discovered that bumblebees can detect and learn about the weak electric fields that arise when they approach a flower. This is the first example of electroreception in a non-conductive medium, aerial electroreception (AE). Recently, we showed that AE can be achieved through the electro-mechanical coupling of mechanosensory hairs to the weak electric field surrounding the animal. This is much like the hair-raising sensation humans used to experience by browsing an arm near to a cathodic television set. Yet, humans cannot sense the weak electric fields surrounding a flower, so this potentially informative physical quantity had escaped scientific attention. To date, little is known about AE, its sensory ecology and evolution. I propose to study the biophysical basis of AE, addressing how and why it works, establishing its adaptive value and exploring its diversity. To achieve this, I will lead research to further understand AE in honeybees and bumblebees, our existing model systems, but also extend research to other arthropods bearing putative electrosensory structures. I will do so using state-of-the-art vibration measurement technology, biologically-relevant electric field generation, sensitive Ampere-meters and electrometers, and behavioural methods. The proposed research will transform our knowledge of electroreception. It will characterize novel detection mechanisms, reveal their adaptive diversity and establish their sensory ecological functions in terrestrial animals. The planned work is poised to be foundational, opening up an entire field of research into this novel, but potentially widespread, sensory modality.

Keywords: biophysics
Dissecting the molecular building principles of locally formed transcriptional hubs (DisMoBoH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Numerous DNA variants have already been identified that modulate inter-individual molecular traits – most prominently gene expression. However, since finding mechanistic interpretations relating genotype to phenotype has proven challenging, the focus has shifted to higher-order regulatory features, i.e. chromatin accessibility, transcription factor (TF) binding and 3D chromatin interactions. This revealed at least two enhancer types: “lead” enhancers in which the presence of genetic variants modulates the activity of entire chromatin domains, and “dependent” ones in which variants induce subtle changes, affecting DNA accessibility, but not transcription. Although cell type-specific TFs are likely important, it remains unclear which sequence features are required to establish such enhancer hierarchies, and under which circumstances genetic variation results in altered enhancer-promoter contacts and differential gene expression. Here, we propose to investigate the molecular mechanisms that link DNA variation to TF binding, chromatin topology, and gene expression response. We will leverage data on enhancer hierarchy and sequence-specific TF binding to identify the sequence signatures that define “lead” enhancers. The results will guide the design of a synthetic locus that serves as an in vivo platform to systematically vary the building blocks of local transcriptional units: i) DNA sequence – including variations in TF binding site affinity and syntax, ii) molecular interactions between TFs, and iii) chromatin conformation. To validate our findings, we will perform optical reconstruction of chromatin architecture for a select number of DNA variants. By simultaneously perturbing co-dependent features, this proposal will provide novel mechanistic insights into the formation of local transcriptional hubs.

Keywords: genetic variation,combinatorial tf binding,transcriptional hub assembly,enhancer hierarchy,single molecule tracking
Solution to authenticate and read ID documents using mobile devices at point of origin in real-time, eliminating manual handling and providing better, more secure services. (ID_MOBILE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-04-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of ID_MOBILE is the development of a market-ready multiplatform system to verify the authenticity of identity documents by means of smartphones and tablets, based on a patent of our property and long commercial experience in the sector. This innovation will drive the change of our company’s current license-based model to a Cloud-based service model as part of our plan for growth into new markets worth €300 million over a 4-year period. At ICAR Vision Systems we have spent the last ten years providing our clients –banks, hotels, casinos, telecoms and IKEA, among others– with the technological edge in the automated detection of document fraud. ID_MOBILE is part of our ID Cloud platform designed to enable smartphones and tablets to reliably perform the same ID reading and verification tasks as our desktop-based systems. This will help solve client support and capture bottlenecks in sectors like Financial Services and Consumer Credit, Hotels and Resorts, Insurance, Telecom, Utilities and others that use validation to avoid identity fraud, a problem that causes losses of up to €500 billion to European companies and €20 billion to EU individuals, according to Commission estimates. The feasibility assessment intended to be undertaken in Phase 1 covers a series of technical issues regarding the capture and processing of identity documents with mobile devices, including the choice of image capture improvement tools for development, the feasibility of facial recognition features, of manual verification modules for detected fraud and of data acquisition by streaming video. Also studied are issues related to the business plan, such as an in-depth market study of new sectors and services, IPR protection and a partner search for technology integrators.

Keywords: mobile devices,security,visual computing,algorithms,advanced cloud infrastructures,identity fraud
Science & Innovation policy in DEbate: COnditions for MaxiMised socIetal ouTputs through mulTi lEvEl analysis (SIDE-COMMITTEE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Duration (months): 36.0
Total project cost (EUR): 295061.76
EU funding (EUR): 295061.76
Participants: 1
Project status: CLOSED

The EU-28’s yearly public Research and Development (R&D) expenditure amounts to more than EUR 100 billion, which must be used in an efficient, impact-driven yet fair way. Funding mechanisms and policies have thus considerably evolved in the last few decades, sometimes with adverse effects. The resulting intense budget scrutiny puts pressure on all categories of actors: at policy (decision makers); implementation (researchers); and receiver (general public) levels, generating category-specific issues and biases that hinder creating optimal funding mechanisms and policies. To provide a solution, this project develops an innovative public engagement approach inspired by participative democracy theory and practices. It will produce for the first time an unbiased mapping of the agendas and needs of all three actor categories and use it to delineate relevant policy recommendations. This ambitious objective will be achieved by focusing on the French system, taking advantage of the research-intensive area of Grenoble where the beneficiary is located. In practice, the Experienced Researcher (ER) will produce a review of the state of the art of public R&D funding mechanisms and policies in France, define the public engagement and debate technique to be used, before implementing it upon 3 separate groups --one for each actor category-- over a period of 1.5 years. This innovative, multi-disciplinary research process and its outcome will be valorised through academic and outreach communications as well as dialogue with relevant national and European stakeholders. This project, marking the return of the ER to a research career in Europe after years working abroad as a practitioner in international relations and research management, features a comprehensive suite of scientific and transversal skills training and knowledge transfer activities that will place the ER as an ideal catalyst for the creation of a local expertise cluster in science policy and the science of science.

Keywords: science policy,research and innovation funding,direct democracy,public engagement
Pilot scale hybrid Photocatalytic Processes for the simultaneous removal of Pathogens and Pharmaceuticals from wastewaters (PreSTO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

In recent years the presence of pharamceuticals (PhAcs) in wastewater treatment plant effluents, drinking water and groundwater has become an issue of emerging concern.The global concentration of these compounds constitutes an effluent organic matter which often serves as precursor for the formation of hazardous disinfection by-products during conventional water disinfection processes. The potential effects of pharmaceutically active compounds on humans and aquatic ecosystems are not completely understood, especially if it is considered that PhACs co-exist in mixtures with other compounds (chemical “cocktails”).The uncontrolled release of antibiotics to the environment promotes the selection of antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB), which shade further long-term health risks to humans and animals To address this challenge, the application of advanced oxidation processes (AOPs) for the removal of residual organic matter and microorganisms has become an emerging area of research. In order to overcome the limitation of individuals AOPs the simultaneous application of light based AOPs looks quite interesting. However, in spite of the progress made in fundamental research at bench scale, the practical achievements in the field of environmental photocatalysis have been modest. The PreSTO project deals with the development and demonstration of pilot plants hybrid photocatalytic processes for the simultaneous removal of pathogens & pharmaceuticals from real wastewater effluents. This will be achieved with a step by step investigation of all relevant aspects, including: (a)development of efficient hybrid advanced oxidation processes (i) Cavitation/Solar photo-Fenton and (ii) Solar photo-ElectroFenton at the unique facilities of CIEMAT SPA (b)development & optimization of state of the art analytical methods and biological assays;(c) photocatalytic evaluation for the elimination of antibiotics and pathogens at hybrid pilot scale reactor.

Keywords: advanced oxidation processes cavitation solar reactor pharmaceuticals hydroxyl radicals solar photocatalysis disinfection micropollutants fenton sonochemistry
E-RESCUE - Changing forever the way we rescue crash victims - Saving time and lives during the Golden Hour (E-RESCUE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2022-02-28
Duration (months): 34.0
Total project cost (EUR): 3231478.75
EU funding (EUR): 2262035.13
Participants: 1
Project status: CLOSED

Buses are regarded as the safest vehicles in the road. However, each year terrible bus crashes are reported in the media. According to the World Health Organization, about 84,500 people were killed on roads in Europe in 2015. Of this figure, about 20,000 European buses and coaches were involved in crashes, with 30,000 bus occupants severely injured, and 150 occupants killed. A critical issue after a bus accident is the efficient rescue of victims. Bus collisions are considered mass casualty incidents, with many victims involved (up to 80 passengers can travel in a bus). This implies that emergency medical services resources, such as personnel and equipment, are overwhelmed by the number and severity of casualties. As a result, the intervention times of emergency services can take too long (more than 2 h) and because the rescue time is critical for survival, bus accidents typically end up with too many fatal victims or severely injured people. The E-RESCUE project aims at introducing into the market the first post-accident safety system to facilitate the rescue of victims after a bus accident and to reduce the emergency services' intervention time, thus increasing the victims’ chances of survival and minimising injuries. This will be enabled thanks to our patented technology, which is the first in-vehicle system for the immobilization and extrication of victims. E-RESCUE is the first system to be installed in all seat buses, so with ERESCUE each passenger would have their own extrication system built into their seat. Thanks to E-RESCUE the rescue time can be reduced up to 70% (30 min Vs 2 h) compared to conventional techniques used by emergency response teams. Hence, E-RESCUE has the potential to reduce the fatal victims and severe injuries in bus occupants by more than 50% in bus accidents. The E-RESCUE changes for ever the way we rescue crash victims. It starts now in the bus industry and it will move forward to the car industry too.

Keywords: post accident safety,road safety,rescue of crash victims
Music Exports and Foreign Cultural Policy in France and Spain (MEFCPFS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2025-09-03
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Digital platforms have dramatically accelerated the global circulation of popular music, creating a new geography of production and consumption in which the so-called ‘language barrier’ between ‘national’ cultures is constantly repositioned. Whilst English has been the dominant language of the global popular music industry since the 1960s, nowadays any artist can speak to a global audience in their own idiom through the use of streaming services and social media. However, despite the apparent immediate and transnational circulation of music, frontiers still exist between countries, and so export remains a crucial category of action for music professionals. Moreover, states’ foreign cultural policies increasingly play a crucial role in music export as part of soft power strategies, thus adapting and contributing to new definitions of national identities. Indeed, whether such policies are related to safeguarding supposedly ‘authentic’ or ‘indigenous’ musics or strengthening the infrastructures of a domestic musical industry, they are confronted with one crucial problem: the meanings and roles ascribed to ‘local’, ‘domestic’, ‘national’, ‘indigenous’ and ‘minorities’ in music. This environment necessitates thorough review of export models applicable to a variety of localised music industries, with a critical approach to contemporary relations between arts and politics. This project aims to examine the nature and characteristics of French and Spanish music export activity within contexts of digitalisation and globalisation, with a specific focus on cultural diversity and a critical stance on the market-driven vision of music export. A comparative study across two non-anglophone nations with official languages of international significance but substantially different attitudes to public spending and linguistic protectionism will serve as a pilot for greater awareness of the social impact of European and global music export.

Keywords: music exports,cultural policy,france,spain