Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Promoting Innovation Excellence in Transformation of Coal Regions to Climate-Neutral, Thriving Economies (COALition)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Romania,Bulgaria,Germany
Call: Excellence Hubs (HORIZON-WIDERA-2022-ACCESS-04, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4489753.75
EU funding (EUR): 4489753.75
Participants: 16
Project status: SIGNED

Energy efficiency, Renewable Energy Sources, Energy Storage/Batteries, Hydrogen, Efficient Buildings, climate neutrality, reduction of greenhouse gas emissions and decarbonization of industries & coal regions are in the heart of European Policies for the new programming period (ie. Green Deal, EU Strategic Energy Technology Plan, Twin Industrial Transition etc.). Many financial instruments have been setup to support these objectives that have a common denominator in sustainable energy. EU alliances across the value chains (ie. EBA), IPCEIs (ie. Descarbonization & Hydrogen, Batteries) and Research & Policy Platforms (ie. Coal Regions in Transition), are dedicated to facilitate the advancement of R&I in the field through the collective effort of EU members, and enable the transformation of EU regions to climate neutral, thriving economies. This context finds a lot of countries striving to comply, especially challenging those that traditionally have economies heavily dependent on fossil fuel mining and exploitation; a major shift has to be done in a short amount of time, putting at risk the balances in the local economies and making years-long expertise and well-established skills become obsolete. COALition intends to strengthen the regional innovation ecosystems in coal-depended areas through the creation of regional excellence hubs and the definition of a joint strategic agenda for sustainable energy so as to facilitate their transition in a just and inclusive way. The regions have been carefully selected (Western Macedonia - GR, Centru - RO, Southeastern - BG) among the under transition EU states that are also characterized as widening, in an attempt to maximize the long-term impact of the joint R&I strategy that will be developed within the project, as those territories are about to amass large amounts of funding and COALition aims to create multiplier effects in the given investments by attracting and mobilizing external investments.

Keywords: sustainable energy,randi strategy,coal regions,just transition,regional innovation ecosystems,excellence hubs,joint action and investment plan,capacity building,sustainability,systemic solutions
Real-time Fine-grained Air Quality Monitoring with Intelligent and Robust Multi-UAV Networks (REFINE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Netherlands,Bulgaria,United Kingdom,Portugal
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 734028.57
EU funding (EUR): 584200.0
Participants: 9
Project status: SIGNED

Air pollution is a significant global concern causing an estimated 4.2 million deaths annually due to diseases related to poor air quality. Climate change is exacerbating air quality issues and posing unprecedented challenges to the existing air quality monitoring systems, which mainly utilize sparse and expensive terrestrial stations and satellites, leading to limited accuracy and flexibility. To address these challenges, REFINE aims to form an international, multidisciplinary, and cross-sectoral consortium with world-leading researchers to create a novel real-time fine-grained air quality monitoring system empowered by advanced technologies in Unmanned Aerial Vehicles (UAVs), Artificial Intelligence (AI), and Wireless Networking. Specifically, REFINE will pioneer research and innovations (R&I) on ground-breaking technologies including: 1) a robust and scalable system architecture for aerial-terrestrial air quality monitoring; 2) intelligent and efficient multi-UAV cooperation strategies for dynamic and flexible area coverage; 3) ultra-resilient and secure aerial-terrestrial networking schemes for reliable and efficient data transmission; 4) lightweight and robust AI methods for accurate and real-time air quality analysis. REFINE will establish a long-term cross-disciplinary and cross-sectoral knowledge-sharing platform with competent and complementary expertise in Computer Science, Environmental Science, and Communication Engineering. The researchers involved will be trained through substantial R&I actions and well-planned networking activities at both European and global levels to enrich their skills and enhance their career perspectives. REFINE will significantly contribute to achieving the EU’s zero-pollution ambition and enhancing European competitiveness, through transforming the current air quality monitoring systems into a new generation, which is able to provide real-time intelligent monitoring of vast rural areas with higher precision and efficiency.

Keywords: unmanned aerial vehicles,machine learning,wireless networks,air quality monitoring
Fundamentals of Combustion Safety Scenarios for Hydrogen (SAFE-H2)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2498191.25
EU funding (EUR): 2498191.0
Participants: 2
Project status: SIGNED

Hydrogen is a powerful energy vector but its deployment at the scale considered today by governments and companies cannot be achieved if safety associated to combustion hazards is not mastered and regulated. Hydrogen leaks occur and lead to fires and explosions which must be prevented. To do this, regulations are needed but these regulations are based today on an incomplete understanding of the fundamental mechanisms controlling the combustion of hydrogen in air or have to consider new usages of hydrogen such as transportation (aircraft, trains, cars…). SAFE-H2 combines theory, high-precision experiments and simulations to provide reliable knowledge on the ignition, propagation, acceleration, mitigation of hydrogen-air flames in three canonical cases: flames stabilized on a hole, flames interacting with a wall, explosions in closed vessels. The proposal gathers (1) IMFT where two experimental sites, dedicated to hydrogen, will be used for low (<40 kW) and high power (300 kW) experiments and (2) CERFACS which provides the High-Performance 3D simulation tools used to compute all IMFT experiments. Experimental diagnostics coming from the aerospace field will be applied to safety scenarios at IMFT to validate simulation tools. SAFE-H2 will focus on generic, simple cases to tackle the fundamentals of hydrogen-air flames so that simulation tools incorporate correct, validated physical models and can replace costly and dangerous experimental tests. All SAFE-H2 experiments will be designed to be used for simulation validations. These detailed comparisons between simulation - experiment will be used to test models for 1) hydrogen-air chemistry in the gas phase and near walls, 2) autoignition and plate ignition, 3) flame-turbulence and flame-wall interaction, and 4) transition to detonation. SAFE-H2 will deliver fundamental science but also models for all simulation codes used in industry and regulation agencies to understand and regulate combustion safety for hydrogen.

Keywords: hydrogen safety high fidelity experiments simulation
More than green - Lighthouses of transformative nature-based solutions for inclusive communities (TRANS-lighthouses)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Portugal,Denmark,Germany,Cyprus,France,Greece,Spain,Belgium,Sweden,Chile,Argentina,Brazil,India,United States,Tanzania, United Republic of,Italy,Kenya
Call: Assessing the socio-politics of nature-based solutions for more inclusive and resilient communities (HORIZON-CL6-2022-COMMUNITIES-01, 2022)
Start date: 2023-05-01
End date: 2026-10-31
Duration (months): 42.0
Total project cost (EUR): 5991692.0
EU funding (EUR): 5991692.0
Participants: 28
Project status: SIGNED

TRANS-lighthouses aims to gather evidence on material and immaterial results of NBS in order to rethink and reframe the main elements that compose the complexity of creating social and ecologically just NBS. More than a driving process, the collaborative work on planning and making NBS functional might stimulate a more concerted response towards environmental and climate crises, increasing the commitment of different stakeholders and upscaling their own spheres of action. TRANS-lighthouses adopts a non-linear perspective and opens up space for the adoption of a fluid and organic position that is able to integrate the diversity of subjects, institutions, knowledge(s), practices and values. TRANS-lighthouses’ ambition is to become a European reference on socio-political challenges for supporting NBS projects and solutions. The socio-politics dimension will be part of the public agenda for NBS towards SYSTEMIC CHANGE. This ambition will be achieved by assessing the benefits and limitations of NBS co-creation that have already been implemented and designed, tested and disseminated economically and socially fairer guidelines for NBS implementation. For this purpose, the project will conduct a thorough assessment, grounded on a transdisciplinary approach and critical analysis. Constituting a well-oiled network of citizens, local governments, scientific institutions and civil society-based partners which acts across borders, disciplines and sectors, TRANS-lighthouses will lead research on activities aiming to implement socioeconomic and political changes capable of enabling pathways for a socially and ecologically just implementation of NBS. TRANS-lighthouses integrates a network of NBS lighthouses for urban, rural, coastal and forested areas in 10 EU countries and 6 non-EU.

Keywords: north south community of practices,co production and governance of nbs,multi scale governance
OPTISYN THERMAL CHEMICAL RECUPERATOR (TCR) (OptiSyn TCR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Slovenia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 8900000.0
EU funding (EUR): 8900000.0
Participants: 1
Project status: SIGNED

The OptiSyn TCR project addresses the problems of instability and uncertainty in the EU natural gas market. Stricter EU regulations on energy consumption and GHG emissions exert increasing pressure on energy-intensive industries. Substantial energy cost further exacerbate these challenges, necessitating innovative, energy-efficient solutions. Procesni Inženiring's OptiSyn Thermal Chemical Recuperator (OptiSyn TCR) is a patent-pending solution designed to address these pressing needs. By leveraging a chemical reaction novelly, it achieves higher energy recovery to help produce a hydrogen-rich synthetic fuel for direct consumption. This multi-level energy recuperation is a pioneering solution to achieve higher energy efficienc. Tested at TRL 6, it can reduce annual gas consumption and CO2 emissions by up to 40%, leading to a potential cost savings of €4,8 billion annually and help industries meet EU regulations. This easily to install and operate solution is compatible with biomethane and benefits many energy-intensive systems. With AI to assist design and operation, it is optimised to be technologically sustainable. OptiSyn TCR not only drives environmental sustainability, but also fosters economic growth and job creation, and resilience of EU industries. With 2 years ROI average, OptiSyn TCR proves being environmentally and socially responsible does not come at a cost. Our clear go-to-market strategy ensures we have a robust plan to capture a significant market share and generate revenue. To realise the full potential, we are looking for funding of €1.9 million in grants and €7 million in investment. This financial support will accelerate OptiSyn TCR's development, enabling its widespread implementation. Led by Ms. Špela Jernejc, whose 30 years of expertise in high-temperature applications have earned her a national nomination, along with a team of competent individuals, are well-positioned to bring a breakthrough innovation that can make meaningful impacts.

Keywords: energy intensive industries,energy efficient solutions,energy independence,ghg reduction,
Revolutionary solution to unlock concrete-to-concrete circularity (C2CA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

C2CA, a spin-out of TU Delft, is transforming the construction industry by upcycling waste concrete into a low-carbon cement substitute, addressing the urgent challenge of reducing CO2 emissions from cement production. Cement accounts for 8% of global emissions, yet its low-cost, availability, performance and versatility make it essential and much desired. Reducing these emissions has been challenging—until now. C2CA’s breakthrough process converts low-value waste concrete into high-quality, low-carbon materials, particularly a highly reactive cementitious binder. Unlike competitors who downcycle concrete into low-grade aggregates, C2CA produces premium materials to replace cement, delivering both environmental benefits and commercial viability. Our low-carbon cement competes on cost and quality with traditional alternatives like fly ash and slag, which are being phased out. While new options like calcined clay and mine tailings are costly or energy-intensive to produce and transport. By 2024, C2CA has developed its core machines on an industrial scale, processing over 1,000 tons of waste concrete. Our materials have been validated in multiple pilot projects, proving technical and commercial viability. The next milestone is building our full-scale upcycling plant. EIC funding is essential for advancing our project, which requires significant capital and has long lead times. Proving our plant’s reliability is crucial for commercial rollout, but we encounter technical, regulatory, and market risks that complicate investment, including energy price volatility and a preference for traditional materials. With the EIC support we can overcome the barriers, complete our flagship plant, demonstrate our technologies at an industrial scale, and build a comprehensive testing facility. This facility will streamline the process at a smaller scale to accelerate innovation and include a material testing lab to ensure the successful market introduction of recycled concrete.

Keywords: circular concrete,waste concrete upcycling,co2 emission reduction,green cement,low carbon cement,decarbonization
Revolutionising the administration of monoclonal antibody therapeutics: from injectables to pills (Intract)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2450000.0
EU funding (EUR): 2450000.0
Participants: 1
Project status: SIGNED

Monoclonal antibody medicines have transformed treatment paradigms in chronic diseases such as cancer, immune disorders and infectious diseases, showing remarkable efficacy. However, thus far these therapeutics are only available as injectables for self-administration or infusion. This can lead to safety issues due to high systemic exposure, suboptimal efficacy due to low drug levels reaching the diseased site, loss of response due to anti-drug antibody development, poor patient adherence to injections/needle phobia, and burden on healthcare systems. We are a spinout company from University College London and have developed a novel platform of drug delivery technologies that enable oral administration of antibodies, unlike the existing injectable therapies. The antibody pill can be taken at home, is efficacious, safer and more convenient for patients, and reduces the burden on healthcare costs and resources. Our platform works by the pill precisely delivering the antibody therapeutic to the colon, which has ten-fold lower digestive enzymes compared to the small intestine, and actively protecting it from enzymatic digestion, thereby increasing residence time and promoting absorption into both gut tissue and bloodstream. We have validated our technologies both in-vitro and in-vivo in preclinical animal models, showing comparable pharmacokinetics and efficacy to injectable antibodies. The goal of this project is to transfer the technologies from lab scale to a GMP manufacturing facility and to test the resulting oral antibody product in a first-in-human placebo-controlled clinical trial, aimed at evaluating the antibody pharmacokinetics in both healthy volunteers and patients affected by inflammatory bowel disease or psoriasis. If proven to work, the platform can have broad-ranging applications, including infectious diseases by offering antiviral antibodies (e.g. Covid-19) orally, which would allow patients an effective and safe prophylactic and treatment option.

Keywords: monoclonal antibodies,mab based therapeutics,oral delivery,capsule,tablet,inflammation,infectious diseases,gastrointestinal tract,targeted delivery,protein stabilisation
WOMED: an innovative intrauterine biodegradable polymer-based drug-delivery platform (WOMED)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 3562697.0
EU funding (EUR): 2493809.5
Participants: 1
Project status: SIGNED

Every woman experiences some form of uterine disorder during her lifetime, including excessive bleeding, pelvic pain, and fertility issues, posing an enormous burden for women worldwide. Current treatments have limitations & painful side effects. Fibroids and endometriosis are two of the most relevant unmet needs in women health. For fibroids, an extremely common condition affecting 51% of women between 35-49, the withdrawal of Esmya, a highly appreciated treatment, has left a gap in effective options. Meanwhile, women with endometriosis (10% women in reproductive years) suffer incapacitating pain that is poorly managed with systemic analgesics. There is an urgent need for better treatments. Womed was founded in Montpellier by Gonzague Issenmann, a serial MedTech entrepreneur, to revolutionize the women health industry by changing the paradigm of uterine disorders treatment. Womed develops safe and effective local intrauterine therapies. Our unique and patented copolymer structure allows for easy insertion, biodegradability and sustained and controlled local drug delivery. Our first product, Womed Leaf, is a drug-free intrauterine device that prevents adhesions and restores fertility. Based on Leaf’s design, we are developing a uterine drug delivery platform with Fibroid, a preoperative treatment for fibroids, and ReLeaf, a nonhormonal treatment to alleviate endometriosis-related pain.

Keywords: biodegradable polymer,intrauterine device,active ingredient,long term treatment,drug delivery platform,fibroids,endometriosis,targeted and controlled release
Arctic sea-ice reconstructions using ancient-DNA. (ARCTISTIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: CLOSED

The Arctic sea-ice is an important ecosystem that guarantees food security and plays a key role in the regulation of the global climate, affecting the livelihoods of people beyond the Arctic region. The Arctic sea-ice is shrinking, and studies predict an Arctic sea-ice free summer by 2050. The impacts of a sea-ice free Arctic on the climate system and human activities are little understood, mainly due to the limited availability of tools to reconstruct and understand the Arctic sea-ice history. State-of-the-art sedimentary ancient DNA (sedaDNA) analyses offer novel solutions to better understand sea-ice ecosystems. ARCTISTIC proposes to i) design and test novel molecular tools (ddPCR assays) to trace sea-ice associated taxa in marine sediments, ii) validate the new ddPCR proxies against established tools for sea-ice reconstruction (lipid biomarkers) and iii) assess the impact of sea-ice changes on biodiversity using metabarcoding analysis on the same sediment samples, and bioinformatics. ARCTISTIC research activities will deliver a novel and innovative toolbox for sea-ice reconstructions. Tools and data will be made available in open access publications, with the aim to accelerate Arctic sea-ice reconstructions beyond ARCTISTIC. ARCTISTIC presents an excellent opportunity for the exchange of the latest skills and approaches for sea-ice reconstruction between myself and NORCE (Norway), with a secondment at AWI (Germany). ARCTISTIC will allow me to develop new skills in sedaDNA methods, palaeoceanographic proxy development and bioinformatics, expand my research network and gain a stronger understanding of Arctic ecosystems and sea-ice history. I will also develop transferrable skills in science communication and project management to ensure a future career path as an independent researcher.

Keywords: sea ice,sedadna,palaeoceanographic proxies,microbial ecology,biodiversity,arctic