Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
First industrial use of bio and ecocompatible geopolymers produced from metakaolin to manufacture tanks for wine, beer, vinegar and olive oil production and storage via 3D printing technology (GeoFood)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The aim of GEOFOOD project is to develop an innovative eco-friendly industrial process to enable the use of geopolymers (produced from metakaolin) and 3D printing technology in the production of food preparation/storage ceramic objects (e.g.vessels for wine, beer, etc. production/storage). Geopolymers have the advantages of delivering food safety to consumers (no use of toxic pigments) and reducing energy consumption. 3D printing brings the additional values of faster manufacturing, full individualization and waste reduction. The business opportunity is tangible: Cibas has already been receiving requests from at least 10 companies from EU and USA, specifically wine and beer producers. These sectors are the initial most relevant market segments, because of their needs for innovative vessels with advantages in terms of biocompatibility, food safety, recyclability. Additional market segments include vinegar and extra-virgin olive oil production.The market potential is significant considering: the growth (+15% in 2009-2016) in tableware, cookingware and items for industrial use. Food/drink industry is the largest manufacturing industry in the EU (turnover of € 956 billion in 2010). This project wants to verify: the technological feasibility (use of industrial grade of food safe metakaolin; validation of geopolymer best formulae for 3D printing); the economic viability (market penetration rate assessment, end users involvement, IP management, innovation strategy). Coherently, in Phase 2, Cibas will carry on activities such as: deployment and validation of an industrial plant; production and testing of scaled-up prototypes; validation of prototypes via panels/focus groups; market exploitation. The project contributes to face some of the main European challenges: a) expected CO2 reduction per year in Europe of 170.625 Tons/CO2; b) reduction of toxic waste (-25.000 Tons) thanks to 3D printing manufacturing; c) more competitive and faster industry (-25%time/piece).

Keywords: food safety,sustainable food production
Generating yeast biodiversity by mitochondrial introgression for wine innovation (Mitogression)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Wine global demand is decreasing due to a shift in consumer preferences and cultural changes. The EU is a GLOBAL LEADER in WINE production, whose wine companies wants to decrease ethanol content, while improving organoleptic properties to deal with these new demands. YEASTS, mainly Saccharomyces cerevisiae, play a KEY ROLE during wine fermentation, when alcohol and the main flavors are produced. Application of new yeasts, produced by genetic engineering, is limited due to the non-acceptance of Genetically Modified Organisms (GMOs). We PROPOSE to apply non-GMO methodologies, to obtain IMPROVED YEASTS by the generation of yeast strains (cybrids), with mitochondrial genomes (mitogression) from non-cerevisiae species, or hybrids, increasing yeast DIVERSITY, to select strains whose fermentation products match wine company expectations. We will ANSWER some BASIC research QUESTIONS: how is genotype molded by the presence of a foreign mitochondrial genome? Are these changes common between independent experiments and wild isolates? And, are evolved strains starting to show evidence of speciation from their ancestors? The results of this project will IMPACT the WINE INDUSTRY by generating new potential commercial strains, and future collaborations. The knowledge gained through this proposal will demonstrate to the scientific community the use of novel methodologies as well as expose the general public to the importance of biodiversity for industrial processes and how the transfer of genetic material and experimental evolution can produce beneficial traits for our societies. The researcher (evolutionary biology and bioinformatics background), supervisor (microbiology, systems biology, and synthetic biology background), and host institution (facilities, knowledge, experience, and supporting elements) will form a perfect entity for the development of MITOGRESSION proposal, and to CONSOLIDATE the scientific career of the researcher for his future INDEPENDENT position.

Keywords: yeast,wine,fermentation,introgression,speciation
Data-driven decision-support to increase energy efficiency through renovation in European building stock. (EERAdata)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Ireland,Germany,Slovenia,Poland,Denmark,Denmark,United Kingdom
Call: Socio-economic research conceptualising and modelling energy efficiency and energy demand (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-07-01
End date: 2022-02-28
Duration (months): 32.0
Total project cost (EUR): 1489033.13
EU funding (EUR): 1489031.63
Participants: 10
Project status: CLOSED

While EU policy assigns a primary role to Energy Efficiency (EE), the lack of a holistic understanding of the impact of EE investments has hindered its integration in the policy-making process. Coordination between demand and supply side of energy policy is not targeted, and there is need to gather the evidence on the benefits of EE in ecological and socio-economic terms as well as on its interactions with the broader policy context and energy market. The EERAdata project aims to address this challenge by supporting policy decisions and related stakeholders with an organic set of instruments to prioritise investments in energy efficiency in the context of the European building stock and its potential for renovation. The EERAdata project will develop and test a decision-support tool to help local administrations in the collection and processing of their building and demographic data towards an assessment and prioritization of EE measures in planning, renovating and constructing buildings. The tool will be operationalized through a software application capable of merging data from various sources, formats and fields, which will then model and assess the impact of energy efficiency investment in buildings across several categories of impact, and against a range of supply-side measures. Partner municipalities will participate to the design of the tool and test its application in regional pilots. The pilots will be part of a wider process of stakeholder engagement aimed at ensuring the usefulness of the different instruments, their applicability across different geographical and economic contexts, and its adoption beyond the life-span of the project. To this end, the project team will establish regional networks of stakeholders centred around the partner municipalities. These networks will be engaged throughout the project to bridge the gap between demand- and supply-side of energy policy.

Keywords: data mining,building stock analysis,cost,benefit assessment,socio economic,environment,life cycle assessment,software tool,municipal renovation strategies,municipalities,policy,supply side
NGS diagnostics in 21st century oncology: the best, for all, at all times (oncNGS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Pre-Commercial Procurement
Countries involved: Italy,Germany,Germany,Italy,Spain,Spain,Belgium,Belgium,France,France,France
Call: Innovation Procurement: Next generation sequencing (NGS) for routine diagnosis (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2026-04-30
Duration (months): 76.0
Total project cost (EUR): 12221843.75
EU funding (EUR): 10999659.379999999
Participants: 18
Project status: SIGNED

oncNGS consortium challenges the market to research and develop novel affordable solutions to provide the best NGS tests, for all solid tumours / lymphomas patients. The challenge will consist in providing: (1) efficient molecular DNA/RNA profiling of tumour-derived material in liquid biopsies by means of (2) pan-cancer tumour marker analysis kit including NGS analysis integrated with (3) an ICT decision support system including analytical test interpretation and reporting. Thanks to the provided solutions, oncNGS consortium will be able to address their common identified unmet medical needs: (1) Establishment of valuable common tumour profiling strategy allowing to provide equal access to innovative medicines to all; (2) Outcome research analysis after treatments with targeted therapies as diverse testing leads to lowering the pooling capacity of obtained results, needed to obtain large enough sample numbers to perform statistics analyses; (3) Application of such essential testing to all patients, breaking down current unacceptable inequities due to the high costs of current diagnostics tests. oncNGS is a strong consortium composed by eight buyers from five member states (SC and IJB from Belgium, IC and HCL from France, HC and LMU from Germany, ACC from Italy and ICO from Spain) supported by six entities with wide experience in their fields (AQuAS from Spain is expert in precommercial procurement, BCR from Belgium and INCa from France are experts in cancer control, IBSAL and VHIO are experienced in biomedical research in the field of haematologic malignancies and DCP is experts in intellectual property rights and freedom to operate analysis) oncNGS consortium will challenge the market launching a pre-commercial procurement procedure, a competitive process enabling the buyers to compare the developments carried out by the contracted suppliers through three phases: solution design, prototyping and clinical validation of a limited set of R&D supplies.

Keywords: next generation sequencing,genomics,liquid biopsies,clinical validity,ec ivd
Next Generation of Micro Gas Turbines for High Efficiency, Low Emissions and Fuel Flexibility (NextMGT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,Norway,Belgium,Belgium,Greece,Switzerland,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 4080240.0
EU funding (EUR): 4080240.0
Participants: 8
Project status: SIGNED

Gas turbines are prime movers based on the Brayton thermodynamic cycle where the working fluid is compressed, thermal energy is then added, before expansion in a turbine to produce power to drive the compressor and produce useful shaft power. The term micro gas turbine (MGT) refers to units producing shaft power below about 500 kW. MGTs can achieve high power density and efficiency, and have the advantage of better fuel and operational flexibility compared to other prime movers of similar power rating. They require less maintenance and the noise level brought about by combustion is lower and easier to attenuate than in competing technologies. Despite previous research and development, MGTs still have a much low market share. Full technical potential has not been achieved due to insufficient investment in research and development and the absence of suitable coordination and innovation sharing mechanisms among stakeholders. The proposed multidisciplinary training and research programme aims at the development of the technical expertise and scientific knowledge that will enable a significantly improved understanding of the fundamental design and operational aspects of MGT technology which involves the development of analytical and numerical multi-physics models that will be validated using experimental data to enable a significantly improved understanding of the fundamental design and operational aspects. Component level technology and their integration in an optimal manner will be addressed. An insight into the main features of the incipient MGT community and the existing structures for collaborative research and technology transfer between research institutions and industry will provide valuable information to pave the way to establishing an important European industry. This would lead the way in distributed power generation and link to renewables utilisation. The outcome is significant contributions to researchers with up-to-date knowledge and skills in this field.

Keywords: energy storage,micro gas turbines,combined heat and power,brayton cycle,cycle optimisation,turbomachinery,intellectual property management,commercialisation,energy policy
Deformations of fundamental Groups of REpresentATions (GREAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2016-12-31
Duration (months): 12.0
Total project cost (EUR): 91727.4
EU funding (EUR): 91727.4
Participants: 1
Project status: CLOSED

The aim of this project is to consider X a smooth projective algebraic curve and a representation ρ of π1(X) into a semisimple Lie group G, and study deformations of ρ when X deforms into a singular curve. This question will open a brand new direction in the theory of representations of fundamental groups and G-Higgs bundles. The main tool to approach the problem will be non- abelian Hodge theory to transform this topological question into the geometric one. Then we use recent new developments in the classification of representations together with new algebraic objects which recently appear in non-abelian Hodge theory to study this question. It will take us to the study the deformations of G-Higgs bundles together with deformations of harmonic bundles over X when X is a curve and varies. This project will allow the researcher to broaden her area of expertise as well as to develop new directions in her research lines. She will complement her knowledge in differential geometry in one of the most prestigious Universities and under the guidance of one of the worldwide leaders in this field.

Keywords: representations of the fundamental group,parabolic higgs bundles,non abelian hodge theory
A Minimal-Tag Bioorthogonal Labelling Approach to Protein Uptake, Traffic and Delivery (TagIt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-10-01
End date: 2023-03-31
Duration (months): 78.0
Total project cost (EUR): 1499106.0
EU funding (EUR): 1499106.0
Participants: 1
Project status: SIGNED

The ability to probe dynamic cellular events that involve disease-associated proteins is limited, to a large extent, by the lack of development of a strategy that can use small coupling partners to react in chemoselective fashion with rapid kinetics that does not interfere with biological function(s) and localisation. In this application, I describe a conceptually new bioorthogonal-labelling approach that combines the introduction of a minimal non-canonical amino acid with chemoselective reactions, which display rapid kinetics, to label proteins in live cells. The small size of the new alkene-tagged amino acids, which will be genetically encoded, should not interfere with the protein’s innate structure, function(s) or localisation. Site-selective bioorthogonal labelling will be achieved through the use of a new photo-triggered [2+2] cycloaddition reaction with an alkene-bearing fluorophore and the known inverse-electron-demand Diels-Alder reaction with a fluorogenic tetrazine. Although the former offers potentially improved spatial and temporal resolution, the latter allows for turn-on fluorescence. The proposed new methodology will be applied in the context of a key cytokine involved in cancer progression. The ability to label this cytokine with minimal perturbation of its structure, function(s) and localisation will enable monitoring of its internalisation and intracellular trafficking pathways in cells that overexpress its receptor. In doing so, new insight into cancer biology will be generated that will inform the construction of safer, selective and more efficient protein-drug conjugates for targeted cancer treatment. The concept proposed here is designed to be generally applicable to label and study disease-associated proteins that are difficult to access by means of conventional protein-labelling methods and constitute the first integrated, interdisciplinary approach for the development of protein drug-conjugates.

Keywords: bioorthogonal chemistry,ligand drug conjugates,photocycloadditions,inverse electron demand diels alder,cysteine,genetic encoding,protein labelling,cancer therapy
Point of care test for non invasive differential diagnosis of obstrutive and non-obstructive azoospermia in male fertility (ANDROTEST)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-10-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project ANDROTEST aims at the development of a non-invasive point-of-care device for the differential diagnosis of obstructive and non-obstructive azoospermia (medical condition of a man not having any measurable level of sperm in his semen) in male infertility cases. Human infertility affects about 25% of couples. For many years, it was thought that infertility was a “woman thing”. Nowadays it is well known that infertility is not such a woman thing, being estimated that in 40-50% of infertility cases, the issue is on the man’s side. One of the most severe forms of male infertility is azoospermia, which is characterized by an absence of sperm in the semen. Azoospermia is diagnosed in 20% of subfertile men and has two forms: obstructive azoospermia (OA) and non-obstructive azoospermia (NOA). OA is caused by a physical obstruction in the male reproductive tract. NOA is a more complicated infertility syndrome with the azoospermia being secondary to a failure to produce sperm. For most men with azoospermia, testicular biopsy is currently the only method to definitively distinguish between OA and NOA. Testicular biopsy is a surgical intervention procedure to remove a small sample of tissue from one or both testicles for further examination under a microscope. The procedure has to be performed by a surgeon or an urologist in an operating room and under local anaesthesia. It is therefore, an invasive procedure that implies significant costs for the healthcare systems and that needs more than 2 weeks to deliver the results, because of the need for expert evaluation of the sampled tissue. The invasiveness of the procedure, the elevated costs and the long times needed to deliver the results, sustain the urgent need for an alternative non-invasive and faster approach with better diagnostic potential at lower costs. This need is the one we have identified as a huge business opportunity we seek embracing.

Keywords: male infertility,point of care,protein biomarkers
When solids become liquids: natural deep eutectic solvents for chemical process engineering (Des.solve)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Portugal,Portugal
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-03-01
End date: 2022-10-31
Duration (months): 68.0
Total project cost (EUR): 1877006.0
EU funding (EUR): 1869129.94
Participants: 2
Project status: CLOSED

Sugars, aminoacids or organic acids are typically solid at room temperature. Nonetheless when combined at a particular molar fraction they present a high melting point depression, becoming liquids at room temperature. These are called Natural Deep Eutectic Solvents – NADES. NADES are envisaged to play a major role on different chemical engineering processes in the future. Nonetheless, there is a significant lack of knowledge on fundamental and basic research on NADES, which is hindering their industrial applications. For this reason it is important to extend the knowledge on these systems, boosting their application development. NADES applications go beyond chemical or materials engineering and cover a wide range of fields from biocatalysis, extraction, electrochemistry, carbon dioxide capture or biomedical applications. Des.solve encompasses four major themes of research: 1 – Development of NADES and therapeutic deep eutectic solvents – THEDES; 2 – Characterization of the obtained mixtures and computer simulation of NADES/THEDES properties; 3 – Phase behaviour of binary/ternary systems NADES/THEDES + carbon dioxide and thermodynamic modelling 4 – Application development. Starting from the development of novel NADES/THEDES which, by different characterization techniques, will be deeply studied and characterized, the essential raw-materials will be produced for the subsequent research activities. The envisaged research involves modelling and molecular simulations. Des.solve will be deeply engaged in application development, particularly in extraction, biocatalysis and pharmaceutical/biomedical applications. The knowledge that will be created in this proposal is expected not only to have a major impact in the scientific community, but also in society, economy and industry.

Keywords: green chemistry,deep eutectic solvents,supercritical fluids,extraction,biocatalysis,pharmaceutics,biomaterials