Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Parallel Water Entry of Hydrophilic/Hydrophobic Projectiles: Experimental and Theoretical Aspects (WE-EXPERTH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

The WE-EXPERTH project aims to study the parallel and simultaneous water entry (WE) of two spheres impacting on a water surface. The physics of WE and of parallel WE is important for a variety of engineering and natural science applications, such as underwater or navy vehicles, coating and spraying processes, marine platforms such as floating offshore wind turbine platforms, invasive free-surface flow measurement devices used in the steel industry, synchronized-diving athletes or plunge-diving birds. Scientific research in this area may lead to measures to reduce slamming loads on marine vessels and platforms, improve the accuracy of free-surface instrumentation, or even explain, why a diving bird does not get injured when it collides with water at high speed. Parallel WE is a highly nonlinear and unsteady process and has thus far not been addressed by research. Interactions are expected to influence air entrainment cavities and pinch-off (which can strongly affect the impact forces and the objects' kinetics) as well as splash curtains and jets (often undesired in engineering applications). During WE-EXPERTH we aim to analyze experimentally (by High-Speed-Camera/PIV/IMU) and theoretically the parallel WE of hydrophilic/hydrophobic spheres and significantly extend current knowledge by investigating the interaction of the involved physical phenomena, analyzing spheres' critical distance and spheres' kinetics for numerous scenarios. WE-EXPERTH brings together an experienced researcher with knowledge in WE, a supervisor with a background in theoretical fluid mechanics, and a host research group with experience in experimental research and image processing. This fellowship will be major step for the fellow towards full-professorship and will enable both fellow and host to continue WE-research beyond the scope of this project. Dissemination efforts will not only focus on scientific communities but also on broader audiences by producing explanatory slow-motion videos.

Keywords: parallel water entry,free surface flow,air cavity,hydrophilic surfaces,hydrophobic surfaces,high speed camera,particle image velocimetry,inertial measurement units
SYnergy of integrated Sensors and Technologies for urban sEcured environMent (SYSTEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Innovation actions
Countries involved: Italy,Germany,Germany,Italy,Germany,Germany,Belgium,Poland,Slovakia,Slovakia,Greece,Sweden,United Kingdom
Call: Integration of detection capabilities and data fusion with utility providers’ networks (H2020-SEC-2016-2017-2, 2017)
Start date: 2018-09-01
End date: 2022-02-28
Duration (months): 42.0
Total project cost (EUR): 9087796.6
EU funding (EUR): 7926171.45
Participants: 25
Project status: CLOSED

The SYSTEM project will design and demonstrate a data fusion system for the continuous monitoring of threats associated to the manufacturing of explosives and to the production and handling of synthetic drugs. Data fused from different mature sensor networks will provide Law Enforcement Agencies with enriched information to assess the potential occurrence of a criminal activity (e.g. to localize the production of improvised explosive devices and/or clandestine synthetic drugs laboratories) in an identified area. Forerunners and basis of SYSTEM are two H2020 IA projects, NOSY and microMole, funded under the call FCT-05-2014. SYSTEM devices will support the detection of home-made explosives and synthetic drugs manufacturing by detecting intermediates and impurities of the production process and precursors used for their synthesis, identifying abnormal use of chemicals transported/provided within the covered urban areas. Additionally, the prevalence of new psychoactive substances including metabolites in the sewage system will be assessed. Deploying a network of sensing systems, working in different and complementary utilities and environments, SYSTEM will acquire and process data from the sewage wastewater and solid waste networks as well as air emissions from target areas in real-time. Such network will consist of different sensing systems, working in different and complementary utilities and environments, Metal-Oxides (MOXs) sensors, Molecular Imprinted Polymers (MIPs), Liquid Chromatography with Mass Spectrometry and autonomous sampling (online LC/MS), fast Gas-Chromatography with Photoionization Detection (GC-PID) and commercial pH and conductivity sensors combined with passive sampling devices and integrated into SYSTEM through a centralised monitoring centre. The consortium will test and demonstrate functionality of SYSTEM in seven different European cities during three years of activities

Keywords: data fusion
Tackling the Electronic Waste Challenge in Emerging Economies (E-Waste Challenge)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Electronic waste (E-waste) or waste electrical and electronic equipment (WEEE) is one of the fastest growing waste streams in the world today. It is a complex stream of waste as it contains both hazardous chemicals and valuable/precious metal components. A major challenge for the research community, therefore, is to find effective (policy) solutions for addressing the environmental and health problems caused by E-waste management in low and mid-income countries while, at the same time, enhancing the recovery of precious metals to reuse these resources. During my Marie Skłodowska-Curie fellowship, I will analyse why emerging economies adopt E-waste policies that seem inadequate and ineffective in their local contexts and identify alternative approaches. In a first step, I will develop a novel analytical framework to analyse the effectiveness of E-waste policies in emerging economies and, as a second step, I will seek to explain the degree of effectiveness of E-waste policies in India and South Africa. The research aims to make conceptual, empirical and policy-relevant contributions: I strive to contribute to the academic literature by developing a novel analytical framework that helps evaluate E-waste policies in non-Western countries. Current literature on E-waste is largely based on assumptions derived from Western policies, polities and societies. By analysing the cases of India and South Africa, my research will focus on two countries whose E-waste policy has hardly been analysed. The findings of the project will provide insights that both the EU and non-European policymakers can use in their decision- making. The EU has a keen interest in supporting non-EU countries tackle their E-waste challenges through effective policies, especially since parts of the E-waste that causes problems in those countries originates from the EU and is a direct result of European consumption. I will contribute to the understanding of how such EU support could be designed.

Keywords: electronic waste,e waste,india,south africa,policy,emerging economy,circular economy,policy effectiveness,policy change,policy transfer,legal transplants,conspicuous consumption
Chemical Engineering of Fused MetalloPorphyrins Thin Films for the Clean Production of Hydrogen (CLEANH2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Luxembourg
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 1900711.0
EU funding (EUR): 1900711.0
Participants: 1
Project status: SIGNED

This project stands in the general context of the current worldwide energy and environmental crisis. It aims to engineer a new generation of conjugated microporous polymers based on fused metalloporphyrins for the low-cost, clean and efficient production of hydrogen from solar water splitting. The CLEANH2 concept relies on the gas phase reaction of metalloporphyrins to engineer new heterogeneous catalysts with remarkable hydrogen production yields. Metalloporphyrins, selected by Nature to fulfil the main catalytic phenomena allowing life, are attractive molecules for water splitting owing to their highly conjugated structure and central metal ion, which can readily interconvert between different oxidation states to accomplish oxidation and reduction reactions. For efficiency and sustainability considerations, it is highly desirable to employ metalloporphyrins in conductive assemblies for heterogeneous catalysis. Nevertheless, due to the lack of synthetic approach, the design and application of conjugated porphyrin assemblies is a largely unexplored topic in view of the plethora of available porphyrin patterns. The central idea of CLEANH2 builds upon our recent advance in the gas phase synthesis and deposition of directly fused metalloporphyrins coatings. Progress in our approach is expected to open the way for the construction of powerful catalytic and photocatalytic materials. To achieve this, the key challenging goals of this project are: 1) the engineering of the microstructure and electronic structure of directly fused metalloporphyrins thin films; 2) the use of the full potential of directly fused metalloporphyrins thin films for the unmet, clean and high quantum yield overall water splitting for hydrogen production. The outcomes of CLEANH2 will be foundational for the engineering of directly fused metalloporphyrins systems and their implementation in advanced technological applications related to catalysis and solar energy.

Keywords: metalloporphyrins,conjugated microporous polymers,chemical vapour deposition,thin films,water splitting,photocatalysis
Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks (evolSingleCellGRN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 1499900.0
EU funding (EUR): 1499900.0
Participants: 1
Project status: CLOSED

Cell types in development arise from precise patterns of gene expression driven by differential usage of DNA regulatory elements. Mutations affecting these elements, or proteins binding them, are major contributors to disease and underlie the evolution of new morphologies. To better understand these elements and how they evolve, I introduce a set of single-cell RNA and ATAC-Seq sequencing technologies that: A) Identify tissue-specific regulatory elements and expression profiles by interrogating individual cells, B) Allow for a precise read-out of developmental responses to mutation and perturbation, including cell-fate re-specification, C) Lead to the development of a regulatory-information based concept of homology that will be used to understand developmental evolution. The research makes use of sea urchins. The well-annotated sea urchin regulatory network, a detailed understanding of inductive interactions in early development, and an active body of evolutionary research justify this choice. Using single-cell ATAC-Seq and a new method for resolving single-cell, nascent transcripts, I will build a detailed atlas of sea urchin development and use this atlas to understand how regulatory landscapes change during specification and how they evolve between closely related species. I will also investigate, at single-cell resolution, how larval skeletal cells are regenerated following the loss of a cell lineage that mirrors euechinoid evolution. To better understand the origins of cell types in sea urchins, I will characterize embryos of the cnidarian Nematostella, using shared regulatory sites to define cell types which I will compare to urchins and my previous work in Drosophila. The work will generate single-cell methods for non-traditional model systems and help to resolve the processes by which, and the paths along which, development evolves.

Keywords: single cell
Antibody-Mediated Therapy of HIV-1 Infection (HIV1ABTHERAPY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Antibodies are destined to neutralize pathogens and can prevent and fight infectious diseases. Over the last years, advances in single B cell cloning resulted in the isolation of highly potent and broad HIV-1 neutralizing antibodies (bNAbs) that have been shown to prevent SHIV infection in non-human primates (NHPs). Recently, we have demonstrated that a combination of bNAbs can suppress HIV-1 replication in humanized mice, reducing viremia to undetectable levels. Moreover, bNAb therapy of SHIV-infected NHPs induced a rapid decline in viremia, followed by a prolonged control due to the long half-life of the antibodies. While these results strongly encourage the clinical evaluation of bNAbs in HIV-1 therapy, it is of critical importance to understand how the therapeutic potential of antibodies can be harnessed in the most effective way. Therefore, we aim to: I.) Identify exceptionally potent HIV-1 neutralizing antibodies that will be a crucial component of immunotherapy. By establishing novel methods for single-cell sorting and high-throughput sequencing we want to identify bNAbs targeting novel epitopes. II.) Prevent HIV-1 escape applying rationally designed treatment strategies targeting conserved functional sites for HIV-1 entry. III.) Evaluate immune markers and function in relation to bNAb administration in humans. Being at the forefront of one of the first clinical trials studying an HIV-1-directed bNAb, we will have the unique opportunity to investigate the interplay of antibody therapy and the host immune system. This proposal aims to strongly advance the field of HIV-1 antibody therapy and therefore enable the introduction of a new therapeutic modality for HIV-1, and will gain insights for antibody-mediated therapy in other infectious diseases.

Keywords: antibodies,hiv 1
Theoretical description of the multifaceted aromaticity and resonance effects in the ground- and excited-state molecular systems (MulArEffect)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Aromaticity and bond resonance are the key concepts in chemistry that rationalize the structure and reactivity of countless number of chemical species. Qualitative assessment of aromaticity and the resonance stabilization effects is crucial for understanding different phenomena in photochemistry, catalysis, organic electronics, supramolecular chemistry, molecular biology etc. However, the real predictive power of these concepts is still dramatically understated, since many of the currently used methods of aromaticity quantification suffer from serious methodological flaws, interpretative mistiness, and computational complexity, which cuts back their applicability to relatively simple molecules. Assessment of aromatic stabilization within the large-scale perspective regarding macrocycles, (bio)catalysts, functional materials, etc., is still a challenge for both experimental and computational chemists. The long-term goal of this project is to understand how aromaticity and different resonance effects determine the physicochemical properties in such systems. In the first goal of this proposal, we aim to develop a novel computational method called EDDB that provides both a detailed description of local aromaticity of selected molecular fragments as well as the bird's-eye view on the global aromaticity of nanoscopic-size molecules and assemblies at a reasonable computational cost. The second research goal of the proposal is to use the EDDB method to gain insights into the mechanisms of the resonance-driven phenomena in the multifaceted aromatics that are instrumental in the design of new catalysts, spin-bearing materials, organic field-effect transistors, etc. Applications in the field of enzyme design and drug discovery are also expected in the long-term. After the execution of this project, the applicant will acquire a wider perspective on the field, strongly enhance his collaborative network agility, and reach a position of full independence and professional maturity.

Keywords: chemical resonance,aromaticity,electron delocalization,excited state,spin density partitioning,energy decomposition,metallacycles,porphyrins,m bius topology,resonance assisted hydrogen bonds
Hydrogen Supply and Transportation using liquid Organic Hydrogen Carriers (HySTOC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Finland,Finland,Netherlands
Call: Liquid organic hydrogen carrier (H2020-JTI-FCH-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-03-31
Duration (months): 51.0
Total project cost (EUR): 2499921.25
EU funding (EUR): 2499921.25
Participants: 8
Project status: CLOSED

Hydrogen is a versatile energy carrier that will allow the EU to accomplish its strategic targets of zero-emission mobility, integration of renewables and the decarbonisation of industry. However, its low density and explosive nature make hydrogen storage and transport technically challenging, inefficient and very expensive. The Liquid Organic Hydrogen Carrier (LOHC) technology enables safe and efficient high-density hydrogen storage in an easy-to-handle oil, thus eliminating the need for pressurized tanks for storage and transport. The HySTOC project will demonstrate LOHC-based distribution of high purity hydrogen (ISO 14687:2-2012) to a commercially operated hydrogen refueling station (HRS) in Voikoski, Finland, in an unprecedented field test. Dibenzyltoluene, the LOHC material used within HySTOC is not classified as a dangerous good, is hardly flammable and offers a five-fold increase in storage capacity compared with standard high pressure technology, leading to a transport cost reduction of up to 80%. HySTOC comprises 5 partners (including 2 SMEs, 1 industrial and 2 scientific partners) from 3 European countries (Finland, Germany, The Netherlands). The partners cover the whole value chain from basic research and testing (FAU & VTT) through core technology development (Hydrogenious Technologies and HyGear) to the end-user that will operate the LOHC-based hydrogen infrastructure (Woikoski). The comprehensive and complementary mixture of expertise and know-how provided by the consortium ensures not only an efficient realization of the technical and (pre )commercial objectives of the project, but also the subsequent dissemination and exploitation of the achieved results to maximize its impact within the consortium and the hydrogen market as a whole. In the long term, the LOHC technology developed within HySTOC will allow integration of renewable energy by making it available to hydrogen mobility in an easy-to-handle form and will thus help decarbonize the world.

Keywords: liquid organic hydrogen carrier lohc,safe and efficient hydrogen storage and transport,hydrogen refueling station supply,pilot field demonstration,economic and life cycle assessment