Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transforming organisational culture for gender equality in research and innovation (GENOVATE)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: Strengthening potential, broadening horizons
Action type: Coordination and support actions
Countries involved: United Kingdom,Ireland,Sweden,Türkiye,Italy,Slovakia,Spain
Call:  (FP7-SCIENCE-IN-SOCIETY-2012-1, 2012)
Start date: 2013-01-01
End date: 2017-06-30
Duration (months): 54.0
Total project cost (EUR): 3185139.6
EU funding (EUR): 2200332.0
Participants: 7
Project status: CLOSED

GENOVATE is an action-research project based on the implementation of Gender Equality Action Plans (GEAPs) in six European universities. It brings together a consortium with diverse experience with gender equality mainstreaming approaches, with varying institutional and disciplinary backgrounds and located in different national contexts. All, however, share common challenges for women engaged in research and all have identified three common areas for intervention: (i) recruitment, progression and research support; (ii) working environment, work-life balance and institutional culture, and finally, (iii) the increasingly important domain of standards and diversity in research excellence and innovation. Each partner university will address these areas through their individually tailored GEAPs that will build on existing structures and policies where relevant, or develop new systems and practices where appropriate. This contextualised approach will be supported by an ongoing knowledge-exchange system within the consortium and by ongoing participatory evaluation, both of which will maximise the shared learning of all partners at every step of the process. An ePortfolio system will allow individual experiences, challenges and thoughts to be documented and collated throughout the implementation process and this will inform the main deliverables of the projects: a social model of gender equality implementation and guidelines tailored to different actors and different contexts highlighting the issues, the challenges and the approaches that work. Dissemination of the outcomes will be shaped by a communications strategy for learning within the institutions, within national learning circles with key stakeholders and, internationally, through networking, media and publication activities. The long-term impact of the project will also be felt within the partner universities: the implementation of the GEAPs involves sustainability strategies for each institution to ensure that ther

Keywords: organisational culture,gender equality change academy,cultural understanding,social model of gender equality implementation,gender equality delivery guides,gender competent research organisations
ProNet - Prosthetic Transgene Networks for the Treatment of Metabolic Disorders (PRONET)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Switzerland
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-05-01
End date: 2018-04-30
Duration (months): 60.0
Total project cost (EUR): 2498800.0
EU funding (EUR): 2498800.0
Participants: 1
Project status: CLOSED

Since living memory, the basic treatment strategies for the therapy of human diseases has not much changed conceptually. Although the molecular understanding of metabolic disorders continues to progress significantly the therapeutic strategy is still based on specific, often heterologous compounds which interfere with critical disease targets, trigger a metabolic bypass reaction or complement a molecular deficiency. As systems biology is revealing gene-function correlations and metabolic network dynamics at great pace and synthetic biology enables bottom-up de-novo design of genetic devices with predictable behaviour, time has now come to develop novel treatment strategies. Prosthetic genetic networks are expected to play a central part of such future treatment strategies. Prosthetic networks are synthetic sensor/effector devices or molecular prostheses which, upon integration into cells and functional connection to their metabolism, monitor disease-relevant metabolites, process off-level concentrations and coordinate adjusted diagnostic, preventive or therapeutic responses in a seamless, automatic and self-sufficient manner. Using a synthetic biology approach and capitalizing on our pioneering prosthetic network designed to control urate homeostasis and treat the tumour lysis syndrome as well as gouty arthritis, ProNet is a highly integrated, multiparallel and interdisciplinary effort to provide a series of prosthetic sensor/effector circuits for precise trigger-control of therapeutic transgenes. ProNet will focus on providing novel treatment opportunities for diabetes and obesity, two core pathologies of the metabolic syndrome, which is on its way to become the top epidemic of the 21st century. ProNet may provide new opportunities for the treatment strategies of the future thereby making the classic therapy of taking pills and getting injections in specified amounts and at particular times likely to become a thing of the past.

Keywords: synthetic biology,biotechnology,synthetic gene networks,gene- and cell-based therapies
Social Innovation on active and healthy ageing for sustainable economic growth (SIFORAGE)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: A more dynamic governance of the science and society relationship
Action type: Coordination and support actions
Countries involved: Spain,Spain,United Kingdom,Germany,Latvia,Spain,Denmark,France,Portugal,Brazil,Italy,Türkiye,Poland,France,Lithuania,Italy,Luxembourg
Call:  (FP7-SCIENCE-IN-SOCIETY-2012-1, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 4078743.63
EU funding (EUR): 3484788.0
Participants: 20
Project status: CLOSED

The general aim of SIforAGE project will be to strengthen the cooperation mechanisms and tools among the stakeholders working along the value chain of active and healthy ageing, with the aim of improving the performance of the European Union competitiveness and growth, through research and innovative products for more and better lives. The objective is change minds and attitudes for a new vision of ageing. This new way of understanding ageing has been embraced under the concept of “active and healthy ageing” (AHA), as an inclusive term to framework the transformation of ageing vision. The specific objectives addressed in the project will be: 1. To develop the supporting tools and mechanisms for the Social Innovation Incubator on AHA 2. To engage and empower society and civil society organisations in research on AHA. 3. To introduce evidence-based policymaking, through training activities with policymakers, to address future shaping of ageing research programmes and funding schemes 4. To raise awareness among the scientific community on the importance of social responsibility and ethics in ageing research, and offer practical guidance on how to address them. 5. To analyse and improve the existing mechanisms for accessing the market of innovative products and solutions for older people 6. To actively involve the wide range of stakeholders of the value chain and spread knowledge generated along the project duration The consortium involved in the project is compounded of 20 different partners at EU and International level, representing a remarkable well-balanced consortium with complementary backgrounds and expertise and representing different stakeholders along the value chain of ageing research, from universities, civil society organisations, final users groups, think tanks, public administrations, technology research centers and companies.

Keywords: active and healthy ageing,longevity,ageing research,social innovation,responsible research and innovation,ageing stakeholders coordination
CholinomiRs: MicroRNA Regulators of Cholinergic Signalling in the Neuro-Immune Interface (CHOLINOMIRS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Israel
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-03-01
End date: 2018-02-28
Duration (months): 60.0
Total project cost (EUR): 2375600.0
EU funding (EUR): 2375600.0
Participants: 1
Project status: CLOSED

Communication between the nervous and the immune system is pivotal for maintaining homeostasis and ensuring rapid and efficient reaction to stress and infection insults. The emergence of microRNAs (miRs) as regulators of gene expression and of acetylcholine (ACh) signalling as regulator of anxiety and inflammation provides a model for studying this interaction. My hypothesis is that 1) a specific sub-group of miRs, designated "CholinomiRs", may silence multiple target genes in the neuro-immune interface; 2) these miRs compete with each other on the interaction with their targets, and 3) mutations interfering with miR binding lead to inherited susceptibility to anxiety and inflammation disorders by modifying these interactions. Our preliminary findings have shown that by targeting acetylcholinesterase (AChE), CholinomiR-132 can intensify acute stress, resolve intestinal inflammation and change post-ischemic stroke responses. Further, we have identified clustered single nucleotide polymorphisms (SNPs) interfering with AChE silencing by several miRs which associate with elevated trait anxiety, blood pressure and inflammation. To further study miR regulators of ACh signalling, I plan to: (1) Identify anxiety and inflammation-induced changes in CholinomiRs and their targets in challenged brain and immune cells. (2) Establish the roles of these targets for one selected CholinomiR by tissue-specific manipulations. (3) Study primate-specific CholinomiRs by continued human DNA screens to identify SNPs and in "humanized" mice with knocked-in human AChE and transgenic CholinomiR-608. (4) Test if therapeutic modulation of aberrant CholinomiR expression can restore homeostasis. This research will clarify how miRs interact with each other in health and disease, introduce the dimension of complexity of multi-target competition and miR interactions and make a conceptual change in miRs research while enhancing the ability to intervene with diseases involving impaired ACh signalling.

Keywords: microrna cholinergic acetylcholinesterase stress gene expression inflammation transgenic mice
Studying at high energies the dynamical and non-thermal processes in astrophysical outflows (ASTFLOW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Powerful relativistic outflows are associated to the brightest sources in the sky. These sources reach their large luminosities at very high energies through non-thermal emission. The relativistic particles responsible of this non-thermal emission are the result of different acceleration mechanisms, which can take place in different regions linked to these outflows. The production of relativistic particles is very sensitive to the local conditions, and therefore their radiation probes the physical properties of the plasmas in which they are generated. Several objects are perfect places to study the physics of relativistic outflows: pulsars, microquasars, and active galactic nuclei (AGN). Depending on the source, these outflows can be either collimated (jets) or wide (winds). Nowadays, the main unknowns of jets and winds concern their formation mechanism, the way how they propagate and dissipate energy, the role of the environment to trigger emission and mass-loading, and the way how they terminate and the global impact on the medium. We aim at answering, studying the high energy emission from relativistic outflows, the following questions: the content and structure of jets in microquasars and AGN at their formation region; the propagation of these jets; the impact of pulsars on their environment in binary systems at all scales; the radiative and dynamical consequences of these outflows when terminating. Different techniques will be used to achieve our goals: semi-analytical modeling; numerical (magneto)hydrodynamical simulations; numerical calculations of radiation transfer; and multiwavelength observations.

Keywords: p301 astronomy - astrophysics and cosmology,radiation processes (radio,x-rays and gamma rays),astrophysical outflows,magnetohydrodynamics,particle acceleration
Randomized Rounding Algorithms in Discrete Optimization and Mathematical Programming (RRADOMP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposal falls into the general area of design and analysis of algorithms for discrete optimization problems. Such problems arise in Business Analytics, Management and Computer Sciences and in all Engineering subfields. The variety of models and problems arising in this area is astonishing. Nevertheless the method of choice to solve such problems in practice is some combination of mathematical programming solver (CPLEX, Gurobi, IPOPT) of a relaxed problem where some of the problem constraints (like integrality of decision variables) are relaxed or dropped and some rounding algorithm that converts a relaxed solution into a solution of the original problem. In many cases such practical algorithms work in multiple stages by slowly transforming the relaxed solution into an unrelaxed one while constantly monitoring the quality of the current solution. On the other hand it was long recognized in the Theoretical Computer Science, Mathematical Programming and Operations Research communities that understanding the performance of various methods to transform an optimal or near-optimal solution of an "easy" optimization problem into a high quality solution of a "hard" optimization problem is the key to understanding the performance of practical heuristics and design of new algorithms to solve hard optimization problems. Such methods are usually called rounding algorithms since they usually transform a fractional solution into an integral one. By designing new randomized rounding methods overcoming the drawbacks of existing methods our capability to solve and analyze optimization problems would increase dramatically both from the viewpoint of understanding the underlying mathematical structure of the problems and practical solving of real-life optimization problems, especially problems that require complicated linear programming relaxations, e.g. transportation, routing, bin packing problems.

Keywords: approximation algorithms,integer and linear programming,combinatorial optimization,randomized algorithms.
Reference Dependence and Labor-Market Fluctuations (RDLMF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-01-01
End date: 2016-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed project is concerned with Reference Dependence and Labor-Market Fluctuations (RDLMF). It aims to incorporate a fairness-based account of the labor relation into a search-and-matching (S&M) model of the labor market in which workers' "productivity" fluctuates across time periods. Our analysis will explore the theoretical implications for equilibrium wage and unemployment fluctuations. We propose a framework, which as in Akerlof (1982), workers' morale (and therefore their willingness to exert discretionary, unobserved effort) is damaged when their wage falls below a reference point. Following the recent literature on reference-dependent preferences that originated with Kőszegi and Rabin (2006), we assume that the workers' reference point is a function of their lagged expectations of their labor-market outcome (specifically, their lagged-expected wage earnings). We hypothesize that the equilibrium predictions of the model are that existing workers' wages display downward rigidity with respect to macroeconomic shocks, while entry-level wages are lower and more flexible. Our model does not introduce new behavioral parameters; We hypothesize that for any given specification of the market primitives, it gives rise to higher volatility of market tightness than in the absence of reference dependence. We believe that the model is capable of producing additional insights into the way the labor market responds to macroeconomic fluctuations, insights which are difficult to address with existing models.

Keywords: e108 behavioural economics,e102 microeconomics
Transforming European Transport through an Active Actors Forum (TRANSFORUM)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: HORIZONTAL ACTIVITIES for implementation of the TRANSPORT PROGRAMME
Action type: Coordination and support actions
Countries involved: Germany,Sweden,Poland,France,Austria,Denmark,United Kingdom,Czechia,Sweden,Germany,Norway,France
Call:  (FP7-TRANSPORT-2012-MOVE-1, 2012)
Start date: 2013-02-01
End date: 2015-01-31
Duration (months): 24.0
Total project cost (EUR): 1906271.1
EU funding (EUR): 1499386.97
Participants: 12
Project status: CLOSED

The TRANSFORuM project is proposed by a consortium of twelve well connected, but independent and experienced policy advisers and researchers from across nine European countries who offer a “fresh ap-proach” to helping to implement four key goals of the European Transport White Paper. The project will initiate a discussion forum of relevant actors by organising meetings and thematic groups on the four selected White Paper goals. The forum will form the environment for a balanced and open discussion process with special attention to research and innovation. It will be linked with all relevant related activities and networks. TRANSFORuM will produce concrete implementation-oriented outputs, including recommendations and roadmaps of joint actions as required by the actors and stakeholders. The TRANSFORuM concept is based on a proven process including wide consultation especially of actors who are directly connected to implementation of innovative policies and measures. The project partners will work along seven work packages and four Thematic Groups - each of which led by a partner with comprehensive experience. Over a lifetime of 24 months TRANSFORUM will deliver 11 stakeholder meetings directly involving 260 stakeholders and actors. Furthermore a quality stakeholder database will be set up. The project cost is 1.499.387€ and includes efforts of 148.5 person months, i.e. over 6 full-time experts over the project lifetime. The project activities are carefully targeted to fully reach the desired content and communication impacts. A permanent internal and external quality control will be applied, and a risk management process is in place. The project will apply targeted dissemination and communication activities to stimulate implementation of the White Paper goals.

Keywords: white paper on transport clean urban transport road freight to rail & waterborne transport complete & maintain the european hsr network european multimodal information,management & payment system
FREVUE VALIDATING FREIGHT ELECTRIC VEHICLES IN URBAN EUROPE (FREVUE)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: United Kingdom,Netherlands,Netherlands,Sweden,Norway,Spain,United Kingdom,Switzerland,Spain,Netherlands,Belgium,Sweden,Portugal,Italy,Netherlands,Spain,United Kingdom
Call:  (FP7-TRANSPORT-2012-MOVE-1, 2012)
Start date: 2013-03-15
End date: 2017-09-14
Duration (months): 54.0
Total project cost (EUR): 13187380.91
EU funding (EUR): 7648806.03
Participants: 33
Project status: CLOSED

Eight of Europe’s largest cities, demonstrate that electric vehicles operating “last mile” freight movements in urban centres can offer significant and achievable decarbonisation of the European transport system. Demonstrators are deployed in Amsterdam, Lisbon, London, Madrid, Milan, Oslo, Rotterdam and Stockholm. The demonstrators have been designed to ensure FREVUE covers the breadth of urban freight applications which occur across Europe. By exposing over 80 electric vehicles to the day to day rigours of the urban logistics environment, the project will prove that the current generation of large electric vans and trucks can offer a viable alternative to diesel vehicles - particularly when combined with state of the art urban logistics applications, innovative logistics management software, and with well designed local policy. The project will demonstrate solutions to the barriers currently inhibiting uptake of EVs in the sector and includes leading European researchers who design and implement a common pan-European assessment framework to understand the impacts of these solutions. This will ensure that the project creates a valuable European evidence base on the role of EVs in urban logistics. The final overarching objective is to encourage the exploitation of the results through a targeted dissemination campaign. To complement this, FREVUE will also create a network of “Phase 2” cities to directly share the lessons learned from the demonstrators. These cities are expected to be the first cities to expand the successful concepts developed by FREVUE.

Keywords: freight,electric vehicles,logistics,urban transport,urban consolidation centre,last mile delivery,vehicle charging,grid stabilisation,policy impact,european best practice