Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of a novel FGL therapy and translational tests for regenerative treatment of neurological disorders (NEUROFGL)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Denmark,France,France,Germany,Czechia
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 7807909.57
EU funding (EUR): 5978735.0
Participants: 7
Project status: CLOSED

Neurodegenerative disorders such as, Alzheimer’s disease (AD), Mild Cognitive Impairment (MCI), stroke, Traumatic Brain Injury (TBI) and chronic stress create a major economic burden to society and a substantial reduction in quality of life for patients and families. The development of neuroregenerative therapies is notoriously difficult and requires significant investment. NeuroFGL will contribute to decrease these barriers through: (1) the clinical advancement of a promising novel regenerative therapy (FGLs) for neurological disorders, (2) hedging the clinical development by developing tests that enable early clinical assessments to be made, thereby maximising the chance that FGL and other neurogenerative therapies actually become developed to the benefit of patients and society; and (3) Selecting a target patient population with less variability and thereby easier to study – reducing and time resources needed, and increase predictability . FGLs is a promising and novel regenerative therapy being the clinical lead development candidate selected from a group of allosteric FGF-receptor modulators (referred to as FGL) mimicking NCAM. FGL has demonstrated positive effects in a number of in vivo models of neurodegeneration, e.g. beta-amyloid induced toxicity, global ischemia and chronic stress. The in vivo effects of FGL suggest a disease-modifying activity in several neurodegenerative disorders, such as neurogenesis. A phase I clinical study has demonstrated a FGL peptide to be well tolerated and safe. NeuroFGL will refine existing and develop new tests and techniques, that will at an early stage of the clinical development: (1) provide better information on the mechanisms of action (NCAM mimicking allosteric FGF recoter modulation) in man, (2) deliver translational effects seen between animal and man, (3) provide results earlier and cheaper, increasing the iteratiation and (4) select patients with conditions associated with less variability, e.g. patients with AD with a specific EEG or patients progressing to AD identified in patients with MCI. These developments will together provide a more robust basis for the development of FGLs, other drugs with a similar mechanism of action and other therapies for neurodegenerative disorders.

Keywords: alzheimer,stroke fgf2,fgfr,ncam,stress,neuroregeration,degeneration,clinical development,brdu,fgl
Quantum field theory, the variational principle, and continuous matrix product states (QFTCMPS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-08-01
End date: 2016-07-31
Duration (months): 60.0
Total project cost (EUR): 1343219.1
EU funding (EUR): 1343219.1
Participants: 1
Project status: CLOSED

Quantum field theories, quantum systems with an infinite number of degrees of freedom, present the most subtle and complex systems in physics. At the same time, the study of quantum field theory has provided us with some of the most powerful theoretical tools to study many particle quantum systems. Many of the major insights in this theory have been obtained using the powerful technology of perturbation theory, whereas a main source of nonperturbative results has been lattice gauge theory. The variational principle has not met with as much systematic success in explaining these systems due to the dearth of good variational wavefunctions. In condensed matter physics we have recently witnessed tremendous progress, spurred by developments in quantum information theory, in understanding the properties of physical states of strongly interacting many particle quantum systems. This has culminated in the realisation that the physics of low-dimensional systems is well captured by variational classes known as matrix product states, projected entangled-pair states, and the multiscale entanglement renormalisation ansatz. Very recently a continuum generalisation of the matrix product state variational class has been developed which promises to afford, via the variational principle, new insights into the behaviour of strongly interacting quantum field theory. The purpose of this proposal is to: (a) understand how to use the variational principle to simulate the dynamics, both imaginary and real-time, of (1+1)- and higher-dimensional quantum field theories within the continuum matrix product state variational class; (b) extend the recent theoretical advances in the field of locally interacting quantum spin systems to study the correlation structure of equilibrium and non-equilibrium quantum fields; and (c) relate the developed formalism to cavity QED and hence develop experimental proposals to simulate strongly interacting quantum field theories with cavity QED systems.

Keywords: quantum field theory,the time-dependent variational principle,continuous matrix product states,entanglement,area laws,simulation,locality
Single-Photon Microwave Devices: era of quantum optics outside cavities (SINGLEOUT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: Finland
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1499445.0
EU funding (EUR): 1499445.0
Participants: 1
Project status: CLOSED

The past couple of years have witnessed the rise of on-chip quantum optics. This has been enabled by the fabrication of high-finesse superconducting resonators made out of coplanar waveguides, and by the coupling of these resonators to superconducting quantum bits, qubits. This so-called circuit quantum electrodynamics (cQED) has proven superior compared with the standard cavity QED with photons coupled to atoms in three-dimensional space. Namely, the coupling of the cavity photons with the qubit has reached strengths completely out of reach with traditional techniques. The energy levels and their populations in the qubits can be controlled in-situ, which has also offered the possibility prepare the quantum mechanical state of the photons in the cavity to arbitrary superpositions of the low-lying photon number states. Although great focus is put worldwide into cQED in superconducting cavities, the field of manipulation and measurement of single microwave photons outside cavities is essentially missing. This ERC starting grant project, aims to expand the power of microwave photons witnessed in cavities to free photons in waveguides. The cornerstone is the design and implementation of a single-photon click detector for microwaves. The detector will allow for the single-shot measurement of the photon state in the waveguide in a similar fashion as the photon detectors are routinely used in optical quantum computing (OQC). Thus together with the already demonstrated single-photon source, the detector will be a critical step towards quantum information processing with microwave photons. In addition to opening this novel field in physics, the detector can be utilized in the characterization of microwave components and devices at ulra-high sensitivities. In this project, we will implement a platform for such characterization and build several circuit elements to manipulate single microwave photons in the same way as beam splitters are used in OQC.

Keywords: microwave photonics
Governance and ethics of nanosciences and nanotechnologies (NANOETHICS 2011)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: Science in Society
Action type: Coordination and support actions
Countries involved: Poland
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2011-01-01
End date: 2012-02-29
Duration (months): 14.0
Total project cost (EUR): 154900.0
EU funding (EUR): 107814.0
Participants: 1
Project status: CLOSED

The main objective of the project is to raise awareness of policy makers, experts, scientists, representatives of industry, third sector and general public in regard to the Commission’s Code of Conduct for responsible nanosciences and nanotechnologies research as well as other developments in governance and ethics of such research. It should also inspire further discussion on these subjects on national and European level, and encourage actions of the EU Member States concerning development of national regulations in the area of responsible nanosciences and nanotechnologies research. The above mentioned objectives will be achieved through organization of the Polish Presidency conference “Governance and ethics of nanosciences and nanotechnologies” (Nanoethics 2011), follow-up activities and the overall promotion of the project. The conference will be organized in Warsaw on 20-21 October 2011. It will have a particular focus on the EC Code of Conduct for responsible nanosciences and nanotechnologies research, and activities of Member States concerning implementation of the Code will be presented and discussed. Stakeholders opinions will be heard as well. The conference will also be an occasion to present other initiatives in the field of governance and ethics of N&N research, and will contibute to dissemination of the results of the EU funded projects in this area. The event is planned for 200 participants. Among them there will be: the EC representatives, policy makers from the EU Member States, scientists, experts, representatives of industry and CSOs, delegates of national academies of sciences, and representatives of media and general public. The event will result in elaboration of the conference proceedings and the post-conference report that will contain summary of the event and recommendations concerning the EC Code of Conduct. Both publications will be broadly disseminated. The conference discussion will be continued on an on-line forum.

Keywords: nanotechnology,nanosciences,governance,ethics,stakeholder,code,conduct,research,commission,conference
Neural network computation for fast trajectory prediction (NEURAL)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-04-01
End date: 2012-05-31
Duration (months): 14.0
Total project cost (EUR): 149755.0
EU funding (EUR): 112316.0
Participants: 2
Project status: CLOSED

The Neural project proposes to take advantage of the neural networks capabilities to approximate the aircraft performance models in order to achieve the High Speed Numerical Integrator pursued by the MTM. The Neural development would allow SGO ITD to evaluate the potential benefit of the Neural Network for improving the access to the performance data. The Neural consortium was created to join the aeronautics and embedded experience of gtd and all the expertise in optimal control and high speed numerical integration with neural networks of the International Center for Numerical Methods in Engineering (CIMNE), a world-wide reference center in its area.

Keywords: neural network,high speed numerical integration toolbox for precise prediction,clean sky
Sustainable prevention of obesity through integrated strategies (SPOTLIGHT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Netherlands,United Kingdom,Norway,United Kingdom,Belgium,Netherlands,Denmark,France,Hungary,Portugal
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-03-01
End date: 2016-02-29
Duration (months): 48.0
Total project cost (EUR): 3797394.15
EU funding (EUR): 2997658.0
Participants: 15
Project status: CLOSED

BACKGROUND The prevalence of overweight and obesity in Europe is high and contribute to mortality and the burden of many chronic diseases, especially within groups of lower social-economic status. Obesity is largely determined by modifiable lifestyle dependent risk factors such as reduced physical activity, sedentary behaviour and an unhealthy diet. There is growing evidence that influences on individuals and their lifestyle should not only be addressed in single-level interventions that focus on a distinct individual, social or environmental aspect, but rather in community based multi-level intervention approaches (MIAs) that integrate individual, community, organisational, and societal systems. OBJECTIVES SPOTLIGHT aims to increase and combine knowledge on the wide range of determinants of obesity in a systematic way, and to identify MIAs that are strong in terms of Reach, Efficacy, Adoption, Implementation and Maintenance (RE-AIM). A further aim is to identify factors for successful implementation of MIAs into health promotion practice. APPROACH By combining published research and collected cross-European data with expert and target-group perspectives, effective, sustainable and implementable MIAs that counteract obesogenic behaviours in adults will be defined. ACHIEVEMENTS We will provide an evidence-based model for effective MIAs in health promotion practice applicable across Europe, and disseminate our findings by policy makers and the scientific community. We will develop a handbook with evidence- and practice-based instructions as well as practical recommendations for policies and interventions, suggestions and reference to best practice that serve as a major dissemination tool. IMPACT Through systematic dissemination of SPOTLIGHT outcomes, the project supports the development and implementation of effective MIAs by local authorities and public health practitioners in order to prevent obesity, reduce the social gradient, and so prevent the related chronic diseases.

Keywords: behavioural change,integrated strategies,multi-level intervention approaches,obesity,prevention,health determinants,health inequalities
The first Galaxies (EGGS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Universe sciences
Countries involved: Denmark
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1002000.0
EU funding (EUR): 1002000.0
Participants: 1
Project status: CLOSED

The goal of this project is to discover the first galaxies that formed after the Big Bang. The astrophysics of galaxy formation is deeply fascinating. From tiny density fluctuations of quantum mechanical nature believed to have formed during an inflationary period a tiny fraction of a second after the Big Bang during structure slowly formed through gravitational collapse. This process is strongly dependent on the nature of the dominant, but unknown form of matter - the dark matter. In the project proposed here I will study the epoch of first galaxy formation and the subsequent few billion years of cosmic evolution using gamma-ray bursts and Lyman-α (Lyα) emitting galaxies as probes. I am the principal investigator on two observational projects utilizing these probes. In the first project, I will over three years starting October 2009 be using the new X-shooter spectrograph on the European Southern Observatory Very Large Telescope to build a sample of ~100 gamma-ray bursts with UV/optical/near-IR spectroscopic follow-up. The objective of this project is to measure primarily metallicities, molecular content, and dust content of the gamma-ray burst host galaxies. I am primarily interested in the redshift range from 9 to 2 corresponding to about 500 million years to 3 billions years after the Big Bang. In the 2nd project we will use the new European Southern Observatory survey telescope VISTA. I am co-PI of the Ultra-VISTA project that over the next 5 years starting December 2009 will create an ultradeep image (about 2000 hr of total integration time) of a piece of sky known as the COSMOS field. I am responsible for the part of the project that will use a narrow-band filter to search for Lyα emitting galaxies at a redshift of 8.8 (corresponding to about 500 million years after the Big Bang) - believed to correspond to the epoch of formation of some of the very first galaxies.

Keywords: emission line galaxies,gamma-ray bursts,near-ir surveys
Network Topology Complements Genome as a Source of Biological Information (BIONET)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: ERC Starting Grant Interdisciplinary Panel
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2017-12-31
Duration (months): 72.0
Total project cost (EUR): 1638175.0
EU funding (EUR): 1638175.0
Participants: 2
Project status: CLOSED

Genetic sequences have had an enormous impact on our understanding of biology. The expectation is that biological network data will have a similar impact. However, progress is hindered by a lack of sophisticated graph theoretic tools that will mine these large networked datasets. In recent breakthrough work at the boundary of computer science and biology supported by my USA NSF CAREER award, I developed sensitive network analysis, comparison and embedding tools which demonstrated that protein-protein interaction networks of eukaryotes are best modeled by geometric graphs. Also, they established phenotypically validated, unprecedented link between network topology and biological function and disease. Now I propose to substantially extend these preliminary results and design sensitive and robust network alignment methods that will lead to uncovering unknown biology and evolutionary relationships. The potential ground-breaking impact of such network alignment tools could be parallel to the impact the BLAST family of sequence alignment tools that have revolutionized our understanding of biological systems and therapeutics. Furthermore, I propose to develop additional sophisticated graph theoretic techniques to mine network data and hence complement biological information that can be extracted from sequence. I propose to exploit these new techniques for biological applications in collaboration with experimentalists at Imperial College London: 1. aligning biological networks of species whose genomes are closely related, but that have very different phenotypes, in order to uncover systems-level factors that contribute to pronounced differences; 2. compare and contrast stress response pathways and metabolic pathways in bacteria in a unified systems-level framework and exploit the findings for: (a) bioengineering of micro-organisms for industrial applications (production of bio-fuels, bioremediation, production of biopolymers); (b) biomedical applications.

Keywords: biological networks
Extended fluorescence resonance energy transfer with plasmonic nanocircuits (EXTENDFRET)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1477942.4
EU funding (EUR): 1477942.4
Participants: 1
Project status: CLOSED

Förster fluorescence resonance energy transfer (FRET) is one of the most popular methods to measure distance, structure, association, and dynamics at the single molecule level. However, major challenges are limiting FRET in several fields of physical and analytical sciences: (i) a short distance range below 8 nm, (ii) a concentration range in the nanomolar regime, and (iii) generally weak detected signals. At the interface between physical chemistry and nano-optics, the proposal objective is to extend the effectiveness of single molecule FRET using plasmonic nanocircuits to: (i) perform FRET on a range up to 20 nm, (ii) detect a single FRET pair in a solution of micromolar concentration, and (iii) improve the statistical distribution in FRET measurements. To meet its ambitious goals, the proposal introduces plasmonic nanocircuits to tailor the light-molecule interaction at the nanoscale. Energy transfer between donor and acceptor fluorophores is efficiently mediated through intense surface plasmon modes to extend the FRET distance range and improve the fluorescence signal. Moreover, the nanocircuits will be combined with recent innovations in biophotonics: stimulated emission of acceptor fluorescence, full dynamic analysis, and fluidic nanochannels. The scientific breakthroughs and project impacts will open new horizons for proteomics, enzymology, genomics and photonics. For elucidating molecular structure, the long range FRET will enable understanding the folding structure of large DNA or protein molecules. For assessing chemical reactions, achieving single molecule analysis at micromolar concentration is essential to monitor relevant kinetics, reveal sample heterogeneity, and detect rare and/or transient species. For analytical chemistry, nanocircuits are ideal for sensitive biosensing on a chip. For photonics, nanocircuits can realize key components for optical information processing at the nanoscale.

Keywords: single molecule,fret,nanophotonics,plasmonics,molecular sensing
Geometry and dynamics via contact topology (GEODYCON)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 887600.0
EU funding (EUR): 887600.0
Participants: 1
Project status: CLOSED

I intend to cross ressources of holomorphic curves techniques and traditional topological methods to study some fundamental questions in symplectic and contact geometry such as: - The Weinstein conjecture in dimension greater than 3. - The construction of new invariants for both smooth manifolds and Legendrian/contact manifolds, in particular, try to define an analogue of Heegaard Floer homology in dimension larger than 3. - The link, in dimension 3, between the geometry of the ambient manifold (especially hyperbolicity) and the dynamical/topological properties of its Reeb vector fields and contact structures. - The topological characterization of odd-dimensional manifolds admitting a contact structure. A crucial ingredient of my program is to understand the key role played by open book decompositions in dimensions larger than three. This program requires a huge amount of mathematical knowledges. My idea is to organize a team around Ghiggini, Laudenbach, Rollin, Sandon and myself, augmented by two post-docs and one PhD student funded by the project. This will give us the critical size to organize a very active working seminar and to have a worldwide attractivity and recognition. I also plan to invite one confirmed researcher every year (for 1-2 months), to organize one conference and one summer school, as well as several focused weeks.

Keywords: contact topology and dynamics