Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PErPetuating Stemness: From single-cell analysis to mechanistic spatio-temporal models of neural stem cell dynamics (PEPS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,France
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-06-01
End date: 2029-05-31
Duration (months): 72.0
Total project cost (EUR): 10858174.0
EU funding (EUR): 10858174.0
Participants: 3
Project status: SIGNED

Neural stem cell (NSC) populations in the vertebrate brain generate adult-born neurons for plasticity, growth, and repair. Neurogenic and gliogenic capacity, based on long-term NSC maintenance, functionally define “stemness”. Stemness embodies massive NSC heterogeneity at the single cell level and requires control of maintenance or differentiation decisions at the population level. These features remain mechanistically unreconciled. We hypothesise that spatiotemporal interactions among heterogeneous NSCs are coordinated to control the population behaviour. Thus, we propose a multi-dimensional project exploring these features in time and space, to decode the mechanistic principles of stemness. To this end, we bring together experimental and theoretical groups with complementary expertise in NSC biology, biostatistics and mathematical modelling. In an iterative experimental-mathematical approach, we will (1) solve the topology of individual NSC trajectories in transcriptomic space, (2) identify local cell-cell coordination mechanisms that impact these trajectories in situ, and (3) decode the resulting systemic properties and outputs of NSC ensembles at long-term and large spatial scales. This programme will result in original methods, including retrospective transcriptomics in single cells, innovative barcode transfers, and a novel mathematical framework to describe structured spatio-temporal population dynamics. We will focus on two biological model systems, the adult mouse ventricular sub-ventricular zone and zebrafish pallium, where NSC ensembles display comparable heterogeneity but differ in spatial organisation and fate dynamics. Together, PEPS will uncover the general principles and regulatory mechanisms of perpetuating stemness in time and space. It will lay the conceptual and methodological foundation to manipulate stem cell systems to improve their stability or output, and also produce new methods of universal value for studying cellular systems.

Keywords: adult neural stem cells,zebrafish pallium,ventricular subventricular zone,spatio temporal population dynamics,single cell multi omics,barcoded transfer connectome,brain injury,single cell perturbations,mathematical modelling,structured population models,partial differential equation,high dimensional statistics,dimension reduction
Revolutionizing Credit Management: Vesta Insights' Explainable AI Solution for Equitable Financial Access (RISE-FAIR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

In today's financial landscape, credit access inequity and arrears management crises pose significant challenges. With one in four individuals denied credit in the US and Europe grappling with arrears due to inflation and interest rate hikes, the need for innovation is critical. Vesta Insights addresses these pressing issues head-on with our groundbreaking explainable AI solution for credit management. Our proprietary AI algorithms revolutionize outdated, bias-prone credit processes by offering transparent, data-driven insights. We uniquely combine bias mitigation, predictive analytics for arrears management, and accurate risk assessments to increase credit access. By providing clear, actionable recommendations and easy-to-understand explanations for all decisions, we ensure both efficiency and fairness. This innovative approach not only enhances credit management but also promotes a more equitable financial system globally. Vesta Insights is poised to transform the industry, adapting to diverse regulatory environments while setting new standards for ethical and efficient credit management. Our solution doesn't just solve problems; it redefines the future of lending, making us a pivotal player in creating a more inclusive financial world.
The Culture of Gender-Based Violence in Early Modern Urban Society: Male-to-Female Spousal Abuse in Eighteenth-Century Madrid in a Global Context (GENVIOMADRID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 397206.72
EU funding (EUR): 397206.72
Participants: 2
Project status: SIGNED

Gender-based violence is now recognized as a global social problem. Worldwide figures on the number of women killed by male spouses reflect the magnitude of the phenomenon. However, its impact was greater in the past, as academic research in early modern Europe and America shows. Such was the case in Madrid. GENVIOMADRID examines the prevalence and evolution of gender-based violence in eighteenth-century Madrid to assess its impact, noting shifts and continuities in the way it was viewed and condemned by the courts and society. Violence against women in eighteenth-century Madrid remains an under-researched topic that requires further analysis. Based on extensive archival research and an interdisciplinary and comparative approach, GENVIOMADRID aims to fill this gap focusing on the study of marital violence against women and examining the case of Madrid in a wider European and global context. It favours a comparison between Madrid and major colonial cities in Spanish America to identify the social and cultural factors that influence changes in the incidence of, and responses to, gender-based violence in societies that, while very different, shared certain legal frameworks, judicial institutions and penal practices. By addressing key contemporary issues and placing gender-based violence in a historical context, it offers an empirical and theoretical background for tackling this social problem today. The action will be carried out at Harvard University in the outgoing phase, supervised by Prof. Tamar Herzog, and at the University of Cantabria during the return phase, under the supervision of Prof. Tomás A. Mantecón Movellán. It will provide interdisciplinary research training in early modern gendered legal and judicial history, colonial Latin American history, and global and transnational history, under the expert guidance of the supervisors, as well as transferable skills. Project results will be made available through a strong dissemination and communication program.

Keywords: early modern history gender based violence crime and justice women s studies social history urban history transatlantic history comparative studies
Democratizing quantum computing with 3D scalable and customizable quantum processors: (DEMOQC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2025-04-30
Duration (months): 28.0
Total project cost (EUR): 3796125.0
EU funding (EUR): 2499700.0
Participants: 1
Project status: CLOSED

Quantum computing is moving from a research field to an emerging industry. But quantum computer integrators face a critical bottleneck: quantum processing units (QPUs) are exceedingly scarce. If a team of innovators envisions a new type of quantum computer, they have two main options. They can either raise enormous capital and build their own QPUs or rely on a university lab for support. This situation reinforces the dominance of incumbent tech giants and stifles innovation when the field needs it the most. We reduce the capital intensity of the field by bringing customizable, scalable, and affordable QPUs to the market. We achieve this by combining three proprietary technologies: parameterized designs, high-yield fabrication, and scalable 3D architecture. We have demonstrated our ability to deliver fully packaged QPUs in less than 30 days to our customers. This project will advance our 3D architecture from prototype to product and offer our customers modular 1000+ qubit QPUs.

Keywords: quantum computing,quantum hardware,superconducting qubits
A platform for Assessing and Bridging Generative AI and Human Skills in Secondary Education (GenAI4ED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Greece,Belgium,Spain,Italy,Cyprus,Ireland
Call: Assessing and strengthening the complementarity between new technologies and human skills (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 3330000.0
EU funding (EUR): 3330000.0
Participants: 11
Project status: SIGNED

Despite the recent emergence of GenAI and large language models (LLMs), numerous educational tools utilizing these technologies have already been developed, with their numbers expected to increase rapidly. Users of such tools are also growing exponentially. AI-based educational tools, leveraging the capabilities of large language models, usher in a new era of education with personalized tutoring, easy content creation, and automatic grading. As the array of available tools expands, educators must acquire digital competencies to select and evaluate the most suitable options. However, the swift growth in GenAI capabilities raises concerns about their impact on students (e.g., misinformation, increased cheating, ethical and privacy issues) and teachers (reduced social interaction, job displacement, and loss). The GenAI4ED project aims to address these challenges by developing a digital platform to consider popular AI-based educational software, evaluate various aspects of each tool, and offer the most suitable option for individual teachers and/or students. Notably, the platform will be employed in pilot experiments in selected schools, whereby students and educators will be asked to evaluate the available tools. Assessment will be based on a predefined set of carefully designed criteria, exploring how such tools affect the student’s experience and how they complement the teachers’ skills and improve their working conditions. Importantly, through an interdisciplinary approach involving experts in AI, psychology, and ethical concerns as well as teachers and parents, GenAI4ED will utilize the results of the pilot experiments to develop policy recommendations on how to harness the benefits of GenAI tools best to enhance the teaching experience for both students and educators, while protecting the teachers’ jobs, improving their working conditions and creating opportunities for new teaching roles.

Keywords: generative ai,secondary education,ethics by design
Glass circulation in the Lower Dniester region in classical antiquity: compositional identification and social network analysis (SocGlas)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus,Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 2
Project status: SIGNED

The project SocGlass aims to model intersocietal interactions in the Lower Dniester region in the Classical period (broadly, 6th c. BCE to 5th c. CE) through the archaeometric compositional study of glass supply patterns, and an investigation of spatio-temporal distribution of glass artefacts modelled by social network analysis (SNA). The vast lowlands north of the Danube delta (Ukraine and Moldova) formed a natural contact zone between the Greco-Roman world and the indigenous peoples of the Pontic region. Glass and glass items were often traded across ethnic and societal boundaries. The diversity of origins of imported glass in the region will be clarified by compositional analysis of glass finds, primarily from the ancient city of Tyras, testing a model of long-term, stable, meaningful patterns of glass supply. The fellow will trace changes in glass composition over a millennium and match them to possible changes in trade patterns, compiling a new model of glass circulation at the LD frontier. The spatial patterns of glass distribution in Greco-Roman cities and sites of the indigenous groups will be quantified and modelled through directed weighted social networks. The latter will be interpreted from a historical perspective looking for evidence of meaningful patterns of intersocietal interactions. Thus, SocGlas will address the issue of social relationships between the Greco-Roman world and indigenous groups, combining archaeometry and SNA to gain unparalleled insight into intersocietal networks in the region of the study. This approach provides a meaningful framework for combining typo-chronological, historic and archaeometric lines of enquiry, but has only rarely been applied to Classical studies and never to an archaeological record of such notable temporal length.

Keywords: glass supply,pontic region,greek colonisation,roman limes,intercultural relations,directed social networks
Title: From Pond to Plate: Evaluating techno-functionality, structural properties, and bioavailability of Wolffia and Lemna-based green egg analogue as emerging protein sources (GreenEgg)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 217076.16
EU funding (EUR): 217076.16
Participants: 1
Project status: SIGNED

This project addresses the urgent need for sustainable and nutritious food sources to meet the demands of a rapidly growing population by harnessing the potential of duckweed species, aquatic plants known for their high-quality protein content. While traditional plant proteins have made progress, emerging sources like duckweed offer the potential to revolutionize food systems. Despite its nutritional benefits, duckweed remains underutilized in food product development. This research aims to close this gap by employing novel protein extraction techniques, specifically pulsed electric field (PEF) and ultrasound technology, both recognized for enhancing protein yield. Through a comprehensive analysis of the techno-functional and structural properties of duckweed proteins, the study seeks to fully unlock its potential. By developing green egg analogues from duckweed protein as a value-added ingredient, this project contributes toward sustainable, high-quality food systems, addressing future food security and improving nutrition for generations to come. Furthermore, the successful development of these egg analogues has the potential to influence future food product innovation, providing healthier and environmentally conscious alternatives that align with global sustainability efforts.

Keywords: rubisco protein,emulsion gel technology,plant based egg analogue alternative,sustainable protein sources
STARs as GRAvitational wave Source Progenitors (Star-Grasp)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1583000.0
EU funding (EUR): 1583000.0
Participants: 1
Project status: SIGNED

Massive stars are fundamental engines in cosmic evolution, providing strong radiative and kinetic feedback to their environment through their copious ionizing radiation and energetic explosions. They also drive the chemical evolution of their hosts. Despite their importance, large uncertainties remain in our understanding of massive stars, including processes such as mass loss, interactions with close companions, and the formation of compact objects at the end of their evolution. The detection of gravitational waves from merging compact objects introduces an important new avenue to study these processes, with an associated large effort from the astrophysical community to understand both how these sources are formed, and how the observed sample can be used to constrain the existing uncertainties. Key questions that are critical to resolve these problems are: - Which intermediate phases in the formation of gravitational wave sources can anchor their evolution? - Can we identify individual progenitors of gravitational wave sources in the nearby universe? - How do the final properties of a massive star relate to the resulting compact objects they form? To address these, the STAR-GRASP project aims to produce a novel theoretical framework to connect constraints from electromagnetic observations to the observed sample of gravitational wave sources. To achieve this we will perform extensive simulations of single and binary star evolution, covering their whole life from birth to their final death-throes as merging compact objects. This will provide multiple predictions on the properties of binary systems with at least one compact object, as well as on the electromagnetic transients associated to their formation. Our new theoretical predictions will be testable in the coming decade, with the advent of large-scale multi-epoch surveys of stellar systems and transient electromagnetic events, as well as the rapidly growing sample of observed compact object coalescences.
Reviving, Boosting, Optimising and Transforming European Film Competitiveness - REBOOT (REBOOT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Austria,Belgium,Greece,Spain,Türkiye,Netherlands,Italy,France,Finland,Poland
Call: Increase the potential of the international competitiveness of the European filmmaking industry (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 3881691.25
EU funding (EUR): 3823688.0
Participants: 12
Project status: SIGNED

This project aims to connect the existing strengths, identify and overcome weaknesses and plan for future competitiveness in the fields of policy, practice and experience. More concretely, the project’s objectives are, on the one hand, to explore the long-standing strengths and pervasive gaps in European competitiveness and policies for competitiveness This includes ways of ‘measuring’ ‘analysing’ and ‘evaluating’ the impact of policies and strategic pathways. On the other hand, the project aspires to place attention to the active preparation for the future in the area of audiences by exploring audience preferences and their generation, as well as modes of film content production. The latter are elements which today’s youth will carry and engage with in the coming decades as makers and consumers, as well as industry and policy leaders. Therefore, the consortium interrogates not only the ‘what is’ but also the ‘what has been’ and ‘what will be’ with fresh lenses. REBOOT’s ambition is to provide a full set of knowledge of the European film industry, which maximises its existing strengths, combined with strategic and tactical dimensions of action for the optimisation of the potential held in European youth publics, understood both as emerging audiences and as citizens Specifically, the ambition of the project combines several dimensions, which reinforce each other but are listed separately for analytical purposes (and in no particular order): a) increasing support for young people’s engagement with European film; b) strengthening the place of the EU in the global audiovisual economy, particularly in light of the rise of video on demand (VOD); c) supporting cultural diversity in the EU film industry; d) addressing the need for a different understanding of competitiveness and relevant indicators in this context; and e) recognising and supporting the importance for the EU of film and, more broadly, of the cultural and creative sector as a geopolitical asset.

Keywords: film industry,global competitiveness,av policy,innovation policy,optimisation,diversity