Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optical properties of hybrid organic/inorganic nano-particles for photovoltaic applications: toward a predictive computational approach (HY-SUNLIGHT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-09-13
End date: 2012-09-12
Duration (months): 24.0
Total project cost (EUR): 222272.4
EU funding (EUR): 222272.4
Participants: 1
Project status: CLOSED

Hopes for a new generation of photovoltaic technology (PV) which may overcome the limitations of the present semiconductor-based technology are based on organic materials, due to their light weight and broad absorption spectrum. In this respect, a special role is played by hybrid organic/inorganic nano-particles. Typical hybrid PV (HPVs) are composite films of semiconductor nano-particles (quantum dots) coupled to organic cromophores active in the visible range. Despite the strong efforts to improve efficiency and stability of HPVs to outperform standard inorganic cells, at present no theoretical/computational approach, going beyond heuristic models, is available to reliably describe the optical excitation of HPVs. These complex systems are untractable by present computational tools due to the very different nature of light-matter interactions in the different segments, leading the respective optical excitations to cover very different length scales. This situation is particularly unsatisfactory as the optical properties of hybrid organic/inorganic nano-particles may find ground-breaking applications in other applied field, notably nano-medicine and biology. The goal of the present proposal is to build the theoretical/computational background for a quantitative modeling of the light response of HPV. The specific objectives are i) a methodological advancement in HPV description, namely, the development of a genuine multi-scale computational method, based on a &apos;hybrid&apos; Configuration Interaction approach, suited to deal with nano-hybrid systems; the new method should be able to describe excitations unique to, and delocalized over, the hybrid system in a nearly parameter-free approach, comparable to standard quantum-chemistry approaches which would not be applicable in this case; ii) the application of the new scheme to selected proto-typical systems of interest for HPV, and the conceptualization of the microscopic mechanisms of their optical properties.

Keywords: computational physics,chemical physics,optical and dielectric properties,physics of semiconductors,molecular physics,applied optics
Cooperative Spectrum Sensing Algorithms for Cognitive Radio Networks (COSSAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-08-01
End date: 2012-07-31
Duration (months): 24.0
Total project cost (EUR): 125733.6
EU funding (EUR): 125733.6
Participants: 1
Project status: CLOSED

Cooperative Spectrum Sensing Algorithms for Cognitive Radio Networks, i.e., COSSAR proposal addresses the major drawbacks of the current cooperative spectrum sensing (CSS) models and techniques. COSSAR, incorporating concerns of practical applications, such as detection algorithms that are able to operate in various environments and a comprehensive communication model that will represent the reality, will produce a comprehensive view of the mechanics and capabilities of CSS and cognitive radio networks (CRNs). COSSAR will open new possibilities and directions for applications and implementations of CRNs by addressing the cognitive base station (CBS) bottleneck. In turn, new research fields will emerge thanks to the results and the outlook of the research outlined in this proposal. Specifically, the drawbacks of the current CSS methods will be addressed by accomplishing the following tasks: 1. Robust Spectrum Detection Algorithms 2. Comprehensive and Realistic Spectrum Sensing Models 3. In-Network Cooperative Spectrum Sensing 4. Implementation and Practical Verification The focus of COSSAR is on the development and rigorous analysis of robust spectrum detectors, the generalization of the CSS communication model, integration of the robust local spectrum detectors and development of robust and optimal CBS fusion functions, design of optimal scarce resource distribution, and finally development of fully distributed in-network CSS algorithms for future applications envisioned for CRNs. The developed computationally efficient cooperative spectrum sensing algorithms will be implemented on flexible hardware platform and experimentally tested under realistic application scenarios.

Keywords: cognitive radio and networks,spectrum sensing,cooperative communications
Histone arginine methylation and citrullination in stem cell maintenance and specification (HISTONESTEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 240289.6
EU funding (EUR): 240289.6
Participants: 1
Project status: CLOSED

Transcription in any given cell type is regulated at the level of chromatin, the complex where all nuclear DNA is packaged together with histones. Post-translational modifications at arginine and lysine residues of histones are key regulators of transcription. Furthermore, histone arginine methylation and citrullination appear to be important in the transcriptional control of several developmental processes. In this project, I intend to investigate the role of histone arginine methylation and citrullination in: (1) the maintenance of the pluri/multipotency status of mouse embryonic stem cells and neural stem cells; (2) the specification of neural stem cells, namely into the oligodendrocyte lineage. Increased understanding of the epigenetic regulation of stem cell fate and oligodendrocyte development is of uttermost importance for the development of cell therapies, in particular for demyelinating diseases. This interdisciplinary project will take advantage of my previously acquired expertise in stem cell biology and neural development, and of the host laboratory’s expertise in epigenetics, chromatin and transcription. I will be using leading-edge techniques such as chromatin immunoprecipitation (ChIP) – sequencing and Stable Isotope Labelling by Aminoacids in Cell culture (SILAC) technology, among others. Thus, this project will allow me to get research training in state-of-the-art techniques in the epigenetics field, which will be essential for my plans to become a principal investigator in the area of epigenetic regulation of neural development, with a focus on oligodendrogenesis.

Keywords: health sciences,developmental biology,neurobiology,brain research,molecular biology,cell biology,natural sciences,biochemical technology
Alchemical Manuscripts in Medical Vienna, 14th-17th century (ALCHEMVIENNA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2011-07-01
End date: 2013-06-30
Duration (months): 24.0
Total project cost (EUR): 156422.8
EU funding (EUR): 156422.8
Participants: 1
Project status: CLOSED

In the late medieval and early modern period, most learned men were fascinated with natural philosophy, the inquiry into the workings of nature. Vienna was among the key places in Central Europe where inquisitive minds met to practice a nature- or medicine-related profession. With its central position in continental Europe, its natural resources (including a long-standing mining tradition) and university, Vienna was also a prime location for alchemical and medical discovery, and many Austrian noblemen investigated the possibility of reviving a faltering economy with the help of alchemists. Medical doctors in and beyond the University of Vienna showed an interest in the use of alchemically produced remedies at various points in history, which eventually resulted in the development of pharmacy as we know it today. Alchemy was a craft and theoretical system that was as ubiquitous as it was debated. However, the history of medico-alchemical Vienna (and hence, Central Europe) written to date is far from complete, and shows one crucial oversight: the Viennese collections of alchemical manuscripts dating from the 14th to the 17th century have not been studied in detail by historians of science at all. This project is going to amend this situation by writing the history of alchemical inquiry and its intersections with medicine in Austria on the basis of Viennese manuscript materials. The project will be undertaken by Anke Timmermann, a young alchemical historian currently active in Philadelphia, USA. She will be working in the environment of the Medical University of Vienna, within the program section entitled “The collections of the Medical University of Vienna”, and utilize its collections of early printed books as reference points for the investigation of the alchemical manuscripts. Altogether, this project will inform our understanding of the relevance of Vienna and Austria to the natural philosophical world of the late medieval and early modern period.

Keywords: humanities,history of science,history of alchemy,history of medicine,manuscript studies,history of the book,medieval history,early modern history
The Molecular Maturation Mechanism of HIV-1 Protease (HIVPROTMOLMECH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 146717.0
EU funding (EUR): 146717.0
Participants: 1
Project status: CLOSED

Over the last decade of AIDS therapy, the HIV-1 protease has emerged as one of the key targets of anti-retroviral inhibitors, owing to its key role in the life-cycle of the virus. The protease cleaves viral polyprotein chains resulting in virion maturation and infectivity. The first stage of this process is the association of such chains containing embedded pseudo-folded protease monomers, followed by the intramolecular autocatalytic cleavage of the protease out of the polyprotein chains. Whilst, the structure, dynamics and function of mature/free HIV-1 protease have been extensively studied at the atomistic level, the molecular structure and binding mechanism of the embedded autocatalytic protease are unknown. Using large scale fully atomistic molecular dynamics simulations on the microsecond timescale, afforded by the computational infrastructure of GPUGrid, the transient structure, dynamics and auto-binding mechanism of embedded HIV-1 protease will be investigated. The aim of these investigations is to distinguish at a molecular level (a) the gating mechanism of mature HIV-1 protease in response to ligands (b) the gating mechanism of intramolecular N-terminal association of the embedded HIV-1 protease and (c) the feasibility of intramolecular C-terminal cleavage by the protease. The release of mature HIV-1 protease is a critical rate-limiting step in the maturation of the virus. Successful inhibition of this stage of the viral life-cycle may lead to a potent increase in the efficacy of AIDS therapy. Unfortunately, structure-based inhibitors designed for the mature/free protease are ineffective against the embedded-protease. A final aim of this investigation will thus be to identify an ensemble of macromolecular structures that could be used as pharmacophores in the development of inhibitors that target the embedded protease.

Keywords: molecular biophysics,computational biophysics/biochemistry,macromolecular chemistry,hiv,drug design,molecular dynamics,supercomputing
Self-assembly of magnetic core-shell nanoparticles at liquid-liquid interfaces for the fabrication of ultra-thin responsive membranes (SALINAME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 173065.2
EU funding (EUR): 173065.2
Participants: 1
Project status: CLOSED

The goal of this project is to study and control the self-assembly of superparamagnetic iron oxide nanoparticles (NPs) stabilized by a shell of responsive polymers at liquid-liquid interfaces in order to crosslink them into ultra-thin, mechanically stable, responsive membranes. This novel “smart” material will have unique properties suitable for applications in miniaturized lab-on-chip and other microfluidics devices. The interdisciplinary nature of the project contributes to its scientific novelty and impact, and constitutes an extraordinary training experience for the applicant. In the first part of the project, the applicant will develop a novel combination of experimental techniques to characterize the fundamental aspects of core-shell NP adsorption at liquid-liquid interfaces. By means of advanced confocal microscopy and particle tracking, complemented by pendant-drop tensiometry, this project will yield an exhaustive characterization, both from a microscopic and macroscopic point of view, of such system, so far practically unexplored. The obtained understanding - of high scientific relevance in its own right - will be used to optimize the design and fabrication of crosslinked responsive NP monolayer membranes. Using superparamagnetic NPs stabilized by a shell of crosslinkable thermoresponsive polymers, the applicant will produce ultra-thin robust assemblies which can respond reversibly to external stimuli. Temperature changes and consequent responses can be imparted to the system locally by exploiting the magnetic functionality of the NP constituents (heat transfer in an AC magnetic field). Moreover the crosslinked membranes can be actuated in DC magnetic fields as envisaged for applications. The responsive properties of the resulting materials, which have no current equivalent, will be investigated by means of optical and atomic force microscopy (structural properties) and microrheology and colloid-AFM force spectroscopy (mechanical properties).

Keywords: physical sciences,surface physics,materials engineering,materials technology
Architectures, morphologies and applications of organic/inorganic nanomaterials containing polyhedral oligomeric silsesquioxane (AMAAOOINCPOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2011-01-03
End date: 2013-01-02
Duration (months): 24.0
Total project cost (EUR): 240289.6
EU funding (EUR): 240289.6
Participants: 1
Project status: CLOSED

Recently, novel nanomaterials with unprecedented properties have attracted great attention, due to the rapid requirement of the emerging technologies in the fields such as biology and microelectronics. In this project, we proposed a novel kind of nanomaterials, organic/inorganic hybirds containing polyhedral oligomeric silsesquioxane (POSS). POSS-containing hybrid polymers with unique architectures will be prepared using advanced polymer synthesis protocols. These hybrid polymers could self-assemble into a rich variety of morphologies in domains with periodicities such as lamellae in bulk or micelle in solution. We will carry out primary test of the resulting POSS-containing nanomaterials for drug delivery applications and explore many other applications such as catalysis and nanoreactors, microelectronics, molecular template, etc.

Keywords: polymer,nanomaterial,silsesquioxane,inorganic,application,technological sciences
Coordinating European Strategies on Sustainable Materials, Processes and Emerging Technologies Development in Chemical Process and Water Industry across Technology Platforms (CHEMWATER)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Coordination and support actions
Countries involved: Germany,Belgium,Netherlands,France,Belgium,Spain,United Kingdom,France
Call:  (FP7-NMP-2010-CSA-4, 2010)
Start date: 2011-05-01
End date: 2013-10-31
Duration (months): 30.0
Total project cost (EUR): 1269718.8
EU funding (EUR): 949296.0
Participants: 11
Project status: CLOSED

Europe must use water more efficiently to avoid the anticipated impacts of water shortage driven by a range of dynamics incl. climate change. Nanotechnologies, materials and process innovations (NMP) are key enabling technologies for efficient industrial water management. The chemical industry has a unique role as major water user AND a key solution provider for the development of future water technologies. ChemWater will coordinate EU strategies across and beyond ETPs on sustainable materials, technologies and process development in the chemical and water industries, with the final objective to integrating and exploiting NMP knowledge and technologies addressing the emerging global challenge of sustainable industrial water management. The ChemWater workplan will deliver: Cross-sectoral synergies between key stakeholders (i.e. ETPs, NoEs, ERA-NETs) drawing on knowledge from chemical processes and water technologies. A long term 2050 vision and strategy on technologies and process developments enabling efficient industrial water management that integrates across sectors disciplines and engages the necessary resources and relevant stakeholders. A Joint implementation Action Plan addressing NMP research needs, skills needs, business development opportunities. Specification of those elements and mechanisms required to ensure the rapid uptake and commercialization of enhanced materials, and processes contributing to optimized industrial water management. Establishment and implementation of an effective dissemination strategy to ensure the communication not only of the project objectives and action plans but also best practices, methodologies and common long term strategies. ChemWater provides an opportunity, to promote progressive science-based industry, foster a sustainable European supply industry, contributing to meet the water needs of society and having the potential to provide Europe with a leading position in the growing global NMP-Water market.

Keywords: process integrated water technologies,materials,chemical industry,implementation action plan
Coordinating for Cohesion in the Public Sector of the Future (COCOPS)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Growth, employment and competitiveness in a knowledge society
Action type: Collaborative project
Countries involved: Netherlands,Germany,Norway,Italy,Spain,United Kingdom,Hungary,United Kingdom,Belgium,Estonia,France
Call:  (FP7-SSH-2010-2, 2010)
Start date: 2011-01-01
End date: 2014-06-30
Duration (months): 42.0
Total project cost (EUR): 3394527.77
EU funding (EUR): 2698927.0
Participants: 11
Project status: CLOSED

The COCOPS project (Coordinating for Cohesion in the Public Sector of the Future) seeks to comparatively and quantitatively assess the impact of New Public Management-style (NPM) reforms in European countries, drawing on a team of leading European public administration scholars. This evidence-based project focuses on the national level and the important policy domains of health and employment services, and the utilities of water, energy and transport. It will analyse the impact of reforms in public management and public services that address citizens’ service needs and social cohesion in Europe. Evaluating the extent and consequences of NPM’s alleged fragmenting tendencies and the resulting need for coordination is a key part of assessing these impacts. Subsequently, COCOPS will map and analyse innovative mechanisms in the public sector to improve policy coordination and its associated effects on economic competition, public sector performance, social cohesion and societal outcomes. The proposed research will contribute to our understanding of the impact of NPM by integrating sectoral and national analyses and to the development of future public sector reform strategies by drawing lessons from past experience, exploring trends and studying emerging public sector coordination practices. Drawing on existing large-scale datasets and innovative data collection in ten countries, the project intends to provide a comprehensive picture of the challenges facing the European public sector of the future. The empirical investigation will result in a transfer of innovative best practices across European member states and a futures study outlining key scenarios for the public sector of the future. It will contribute to maximal policy learning through the involvement of expert practitioner groups and other key stakeholders.

Keywords: new public management,social cohesion,coordination,fragmentation,whole-of-government,integrated governance,outcome steering,public administration,policy cohesion,public sector reform