Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Epidermal growth factor receptor (EGFR) activation by cytohesins - Structural Insights (EGFR-Activ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-04
End date: 2017-05-03
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The epidermal growth factor receptor (EGFR) is a key player in many biological responses and its aberrant function is associated with numerous diseases, including a number of cancers. Despite the significant benefits of anti-EGFR agents in some tumours, many challenges remain in the improvement of EGFR-targeted therapies. This proposal targets cofactors in the EGFR signalling that, so far, were not exploited therapeutically and hence may not only contribute to the global effort in the understanding of this system but may also open new doors to the development of new therapeutic agents. The aim is to use Nuclear Magnetic Resonance (NMR) to obtain structural insights into EGFR activation covering three main aspects: i) modulation of activity by the transmembrane and juxtamembrane domains, ii) the role of the cell membrane and iii) the role of cytohesins in EGFR activation. For this, selected protein constructs will be prepared and their structure and interactions will be characterized. In parallel, new NMR methodology to improve the study of challenging biological samples, specifically EGFR, will be developed. The work plan will provide an innovative and multidisciplinary training covering different areas in Life Sciences and allow the researcher to experience work in an industrial environment through a secondment. We anticipate to obtain structural information that contributes to the global knowledge on these systems and to the discovery novel therapeutic agents. Moreover, the innovative methodologies that will be used in terms of the acquisition of multidimensional NMR experiments have the potential to change the way current investigation of challenging biological samples is done by NMR spectroscopy.

Keywords: nanodiscs,membrane proteins,nuclear magnetic resonance
Integrated SOlution to enhance COLD chain and logistic tracking (ISO-COLD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Scenario Transport & Logistic (T&L) sector has experienced a fast expansion in the last decade; the temperature controlled supply chain represents a high value added segment that is experiencing a continuous push for service quality. Regulators, all over the world, are constantly introducing more demanding recommendations (e.g.: the recent Good Distribution Practise - EU C343/01 2013 - for the pharmaceutical products). On the other hand, the high cost of monitoring tracking information and temperature data during transports, and the absence of structured ICT solutions to aggregate operative information efficiently, risk frustrating regulators effort. Innovation ERPlan developed a comprehensive ICT solution able to collect and aggregate information from T&L operations, including track & trace and temperature data that allow the users to have a complete and updated status of deliveries, an historical records depot for regulation compliance, and a platform to distribute data to its stakeholders. Moreover, the solution provide logistic floor and mobile systems equipped with state of art RFID technology to minimize impact of data acquisition procedures on workforce efficiency. Target Market Transport and logistic companies working with temperature controlled shipments (mainly Pharma & Food sectors) are all potential users of the solution as well as their stakeholders (Pharma / food producers, retailers, etc.) with a focus companies operating in last mile delivery scenario (mostly SMEs) Phase I Objectives - To define the investment and the effort that the company should undertake to penetrate efficiently the European market - To validate the ability of the solution to bring economical return to the company into a defined period in order to evaluate sustainability of the business plan - To quantify the impact of the solution on standard transport / logistic scenarios to create appropriate selling tools - Produce a sustainable marketing strategy to enter the European market

Keywords: temperature controlled logistics,cold chain,rfid,data logger,integrated track and trace system,supply chain management,good distribution practise,mobile computing,proof of delivery
Hardware Implementation of Pilot-Non-intrusive cOgnitive States Identification System (HIPNOSIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Switzerland,France,France
Call: Design and development of smart sensors for detection of human cognitive states implementable in cockpit environment (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2021-10-31
Duration (months): 36.0
Total project cost (EUR): 968166.25
EU funding (EUR): 848963.13
Participants: 3
Project status: CLOSED

With ever increasing air traffic and the fierce competition between airlines, cost reduction is exerting more and more pressure on airlines, inevitably transferred to pilots whose profession becomes increasingly demanding. The adoption of new ground technologies has the potential to increase safety while decreasing operating costs. Platform 3 of LPA IADP aims to develop disruptive flight-qualified cockpit operations concepts by a major design re-thinking towards a “human-centric” approach to operate aircrafts. The ultimate goal is to reduce crew workload, improve fatigue-related safety, situational awareness and support disruptive cockpit operations. HIPNOSIS will contribute to develop the next generation cockpit by providing a hardware and software implementation of smart sensors to monitor cognitive states such as drowsiness and fatigue, which will allow a great leap in flight safety. HIPNOSIS approach is to implement two sensing systems: (1) a vision-based system integrated in the cockpit dashboard to continuously monitor the pilots in the cockpit and detect suspicious behavior linked to drowsiness and (2) a smart wristband which will sense several bio signals through advanced optical sensing technologies, before, during and after the flight. The system will be interfaced to a “pilot state monitoring system” resulting from a previous development in Platform 3 of the IADP. The system design shall be compliant with aircraft cockpit installation, the operational environment and pre-certification requirements to reach TRL6, which will be verified after successful deployment in a Falcon 7X cockpit. The HIPNOSIS consortium brings together partners able to cover the whole value chain of innovative product development: SERMA Engineering (F), an OEM for aeronautical equipment, CSEM (CH), an RTO experienced in innovative technologies and INNOV+ (F) a startup company developing and selling standalone systems for cognitive states monitoring for the automotive industry.

Keywords: avionics drowsiness fatigue perclos sensors cameras wristband vital signs
NGOs, Transnational Networks and the Transformation of Muslim Communities in Cambodia (TRANSCAMUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-03
End date: 2022-02-02
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

Since the 1993 reinstallment of the monarchy after the devastating rule of the Khmer Rouge and the subsequent Vietnamese occupation, foreign NGOs have been mushrooming in Cambodia. Several among these are charities that are based in Malaysia and the Arabian Gulf, and which have become the core of Muslim transnational networks that intersect in the country. These charities invested vast resources in order to reconstruct the Cambodian Muslim religious infrastructure and leadership, that had been almost completely wiped out during the Khmer Rouge. At the same time, they spread their own religious ideas and discourses among the country’s Muslim minorities. This research will inquire into how transnational Muslim networks and charities based in the Middle East and Malaysia have transformed the religious identity, leadership and infrastructure of Cambodia’s Muslim minorities. I will look into the evolution of the Gulf and Malaysian charities in the country, the patterns of the existing competition between them, and how the transnational flows and the transformation of the Islamic field altered the structure of gender relations among Cambodian Muslims. The chief method of data collection will be ethnographic fieldwork conducted in Cambodia, Malaysia and Kuwait.

Keywords: cambodia,kuwait,muslim ngos,muslim minorities,malaysia
Microwave Diagnosis of Breast Cancer with Open Ended Contact Probes (MIDxPRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-08
End date: 2019-07-14
Duration (months): 24.0
Total project cost (EUR): 157845.6
EU funding (EUR): 157845.6
Participants: 1
Project status: CLOSED

This action proposes to carry out research in open ended contact probe (OECP) technique to lay out foundation work for development of two new applications: an automated surgical margin detection device for breast cancer treatment and an automated microwave biopsy probe for breast cancer diagnosis. While the envisioned applications require a single and highly accurate measurement, OECP technique suffers from high error and low repeatability dielectric property measurements. The error mostly stems from the current mathematical approach utilized for the dielectric property retrieval which may converge to local minimum and can magnify the measurement set-up based errors. This research will first target the existing error by proposing robust mathematical retrieval approaches. Next, application based modifications will be investigated with new probe structures. Finally, further error minimization will be achieved by introducing classification algorithms. Developed techniques will be validated with animal experiments. The outcomes of this research will greatly contribute to the innovation of new medical devices that can be utilized for breast cancer, representing one of the most commonly diagnosed cancer type among women. The researcher is well-equipped and has the required capabilities to execute the objectives of this research. The host organization and supervisors have an extensive track record in medical device development, necessary infrastructure, network, and expertise. This research will allow the researcher to become independent by extending her network, publication/grant track record, skill sets, and more importantly, through joining an innovation oriented host organization, the researcher will gain expertise in phases that enables the research to be transformed into innovation. Finally, the goal of the proposed research, building the foundation for innovation, is also in line with ‘Future and Emerging Technologies’ call of the H2020 work program.

Keywords: dielectric properties of biological tissues,open ended coaxial probe technique,breast cancer diagnosis,machine learning,inverse problems,dielectric spectroscopy,rat experiments
Role of the cardiac neural crest cells in heart development and regeneration (Heart2019)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 255756.24
EU funding (EUR): 255756.24
Participants: 2
Project status: SIGNED

In all vertebrates, heart development is dependent on the interplay of several cell populations of distinct embryonic origin. One of these cell populations is the cardiac neural crest (CNC) which contributes to the outflow tract and spiral septum in amniotes. However, CNC cells also migrate to the ventricles and differentiate into cardiomyocytes both in zebrafish and in amniotes. Interestingly, recent results from one of the host lab have shown that CNC-derived cardiomyocytes in zebrafish have an extraordinary capacity for regeneration and that ablation of these cells blocks heart regeneration. Here, I will explore whether this regenerative capacity of cardiomyocytes is unique to zebrafish or represents an ancestral state of characters for vertebrates in general. The goal of the proposed research is to use phylogenetically important vertebrates (lamprey, sturgeon, and axolotl) to answer fundamental questions about the development of the CNC and its role in heart regeneration across vertebrates. Thus, we aim to i) examine the fate of CNC in three species; ii) determine the potential of CNC to differentiate into cardiomyocytes; iii) examine the gene expression profile of CNC cells and neural crest-derived cardiomyocytes; iv) ablate neural crest-derived cells and examine their function in heart regeneration.

Keywords: heart,development,cardiac neural crest cells,stem cells
The History of New Media in Turkey: Radio, Television, and Mobile Devices (HNMT)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Türkiye
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 157355.52
EU funding (EUR): 157355.52
Participants: 1
Project status: CLOSED

When radio was first introduced in Turkey in the 1920s, people considered this new medium an alien technology that promoted Western imperialism. In the 2000s, however, the Western origins of digital technologies—as the new media of the present—went unnoticed and they were mostly welcomed as new venues for expressing upward mobility, class distinction, and alternative political opinions. These shifting public responses to new media forms in countries such as Turkey—that are never fully “Western”—have received little attention from media scholars, who mostly trace similar histories in Western contexts. Filling this lacuna in interdisciplinary media studies, this project examines the changing relationship of technology to global, class, and gender inequalities since Turkey’s foundation as a nation-state in the 1920s to the current era. By specifically analyzing the country’s course from a nationalist and developmentalist economy to neoliberalization, the project addresses two particular questions: 1) As new political economic conditions transform gender, class based, and global inequalities, how do these newly reframed hierarchies make visible a medium’s novelty? 2) How does this perceived novelty inform the ways that lower and middle classes, different gender groups, and state officials use new technologies to challenge or reproduce inequalities? The study combines participant observation with archival research and comparatively examines the citizens’ and the state officials’ reactions to new media forms in three periods: radio in the 1920s, television in the 1950s, and mobile devices in the 2000s. As the first comprehensive study on the history of new media forms in a nation-state such as Turkey—that is at the intersection of Europe and the Middle East—my work highlights how technological novelty is constructed in relation to global and national hierarchies. It also shows that not only inventors but also users play a key role in creating technological newness.

Keywords: new media,digital media,political economy,radio,television
PlusMe: Transitional Wearable Companions for the therapy with children with Autism Spectrum Disorders (PlusMe)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2019)
Start date: 2020-09-01
End date: 2022-05-31
Duration (months): 21.0
Total project cost (EUR): 99375.0
EU funding (EUR): 99375.0
Participants: 1
Project status: CLOSED

+me is an experimental soft interactive toy with a panda form designed in collaboration with developmental therapists. Thanks to embedded electronics, +me can emit attractive responses as colored lights and amusing sounds when touched on paws. The device is connected to a control tablet to allow an adult caregiver to modify the input-output contingencies, so as to produce several rewarding response patterns according to child’s reaction. These features make +me a potential support tool for therapy of children with Autism Spectrum Disorders (ASD): the attractiveness and the functional versatility of the device could be exploited during play activities with a therapist to capture the interest of children, to encourage their social interactions, then reinforcing pivotal social skills as imitation, eye-contact, turn-taking. +me is currently in experimental phase, in pilot tests on children (24-48 months) with ASD and Typical Development (TD). The experiments are conducted in collaboration with the Sec. of Child and Adolescent Neuropsychiatry -Univ. of Rome “Sapienza”- whose researchers showed great interest to technological aid for therapy. +me is an indirect -yet really promising- outcome of the ongoing FET project “Goal-based Open-ended Autonomous Learning Robots, GOAL-Robots” (Grant Agreement No. 713010). The main goal of the proposal is to develop the +me from the current experimental prototype towards a “ready-for-market” product, certified for safe use in EU. The proposal aims to 1) engineer the prototype, through a third party company expert in electronic manufacturing, in order to realise a small-scale production of 10/20 working +me samples; 2) at the same time, continue the experimentation on TD and ASD children, to strengthen the scientific aspects of the device; 3) disclose the obtained results through scientific publications and participation to promotional events market-oriented, in forecast of a next possible commercialisation.

Keywords: behavioural therapy,soft robotics,interactive devices,internet of things
An inquiry into the foundations of PERCeived INEQuality (PERCINEQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-14
End date: 2022-10-13
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Rising levels of inequality has become a key political, economic and social issue in recent years. Nevertheless, many studies show that individuals are much more likely to be influenced by subjective rather than objective inequality. For such reason, perceived inequality is becoming an increasingly popular topic among scholars and non-academic experts. Despite the growing number of studies, little is still known about what perceived inequality is exactly and how it can properly measured given that it is a contested, multidimensional and unobservable concept (1 research objective). Moreover, it is still not clear why people wrongly assess it and which are the consequences of such misperception (2 research objective). The first research objective aims at contributing to a general theory of perceived inequality defining perceptions within models of human behaviors through an interdisciplinary review of the literature. Moreover, improved measures of perceived inequality will be elaborated applying cluster analysis to multiple indicators. The second objective of the research focuses on the identification of the main causal mechanisms driving inequality misperceptions (limited rationality or emotional innumeracy) and its consequences in our society. Such objective is pursed through the creation of an original questionnaire and the implementation of a survey experiment for the collection of new data. Doing so, the simultaneous test of the two causal mechanisms can be implemented for the first time in the literature of perceptions of inequality. The survey will also allow to explore the political and economic consequences of misperceiving inequality. When considering political consequences, the research focuses on political unrest and populist voting (e.g., Brexit, Trump, Lega Nord in Italy); while for economic consequences, it focuses on preferences for redistribution. Important policy implications for our knowledge-based society are expected from PERCINEQ.

Keywords: inequality,perceptions,preference for redistribution,political behavoiurs