Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Self-replicating Colloidal Assemblies (REPLICOLL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-08-31
Duration (months): 74.0
Total project cost (EUR): 1907325.0
EU funding (EUR): 1907325.0
Participants: 1
Project status: CLOSED

Self-replication is the preeminent property of living systems and natural materials. Nature builds and repairs by self-replication. Purely synthetic materials so far lack this important ability. An indispensable prerequisite is the multi-directional control of interactions between the building blocks of materials. In order to generate colloidal building blocks, which are able to self-replicate in a non-biological two-step process, i.e. without the use of DNA, we propose to create a new class of patchy colloidal particles bearing three patches of two different chemical functionalities. The new production process will yield precise control over the patch location and chemistry and thus also gives particles that go well beyond known ABA- or ABC-type Janus particles. For synthesis and replication of colloidal superstructures (e.g. particle strands), the colloids will carry two patches that allow irreversible crosslinking of the self-assembled master-strand and one patch that serves for the recognition and reversible attachment of the single particles along the colloidal chain for the replication process. Thus, in analogy to the polymerase chain reaction (PCR) for DNA replication, single tri-valent colloids will reversibly attach to the colloidal master strand, followed by inter-particle crosslinking of the newly formed strand, which then is detached form the master by opening the bonds between the strands. The released chain copy will then serve as template for further replication processes in which the number of copies will double after each cycle. With this approach we aim to establish a technology platform for the production of sufficient quantities of simple and complex colloidal assemblies, where a well-defined or complex master-structure can only be produced and isolated in small amounts due to a difficult and tedious synthetic procedure.

Keywords: patchy particles,colloidal self assembly,particle functionalisation,directed self assembly
Will this fire burn out? The topos of lovers' separation in the Italian Renaissance (FUDOGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The project aims to achieve the first in-depth study on the lyrical topos of lovers’ separation (i.e. when a lover has to go away and therefore leaves her/his beloved for some time) in the Italian Renaissance. The study is meant to improve our knowledge about: 1) the different ways to read and re-use the tradition in the Renaissance; 2) the role of Petrarch as an authority in Renaissance love literature, also in comparison to other models; 3) the interaction between lyrics and love treatises, as well as between literature and philosophy in the conception and representation of love in the Renaissance. For such a goal, Dr. Favaro will analyze the topos of lovers’ separation in Renaissance lyrics and love treatises, paying attention to their mutual interaction, as well as to the relationship with the previous literary tradition and with philosophical sources (especially Neoplatonism). He will also achieve the commented editions of two little-known Renaissance dialogues entirely devoted to the subject of lovers’ separation.

Keywords: italian literature,renaissance,petrarchism,lyrics,love treatises,love philosophy
Targeting of host proteins by unrelated pathogen effectors and their surveillance by allelic immune receptors (TOPPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Pathogens secrete effectors into host cells to promote virulence and often establish disease by interception of basal defence components. One widespread mechanism of disease resistance in plants requires nucleotide-binding oligomerization (NOD)-like receptor (NLR) genes. Recognition of an effector by a cognate NLR prevents pathogen proliferation. A co-evolutionary arms race between the host barley and the pathogenic powdery mildew fungus Blumeria graminis forma specialis hordei (Bgh) has driven the functional diversification of allelic NLR variants encoded at the MLA disease resistance locus (for Mildew locus A). Recent work revealed that Bgh effectors detected by allelic MLA receptor variants are unexpectedly sequence-unrelated and evolved independently from different ancestors. Additionally, the MLA orthologs in wheat and rye, Sr33 and Sr50, confer isolate-specific resistance to the stem rust pathogen Puccinia graminis forma specialis tritici (Pgt). This is remarkable because rust and mildew fungi belong to different phyla and cannot encode sequence-related effectors. MLA variants can therefore not have diversified to directly bind sequence-related effectors and thus monitor effector-mediated modifications of host targets conserved between different cereals. To reintegrate into the European scientific community, I wish to perform the “TOPPER” project at the Max-Planck Institute for Plant Breeding Research, Cologne, Germany. The “TOPPER” project will clarify whether the sequence-unrelated Bgh effectors target the same host protein or converge on a common signalling pathway/complex consisting of related or unrelated host proteins. I hypothesize that the host protein(s), manipulated by Bgh effectors, is/are also targeted by effectors of other plant-associated microorganisms, which will be tested here. The collaboration with the partner ‘2Blades’ will ensure direct deployment of results in agriculture to battle plant disease, where appropriate.

Keywords: host,pathogen co evolution,effectors,powdery mildew,community profiling
SoCial Finance for SOcial EnterPrisEs: TheoRy aNd PractICe to bUild a more incluSive society (COPERNICUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2024-11-01
Duration (months): 36.0
Total project cost (EUR): 237768.0
EU funding (EUR): 237768.0
Participants: 2
Project status: SIGNED

The purpose of this project is to analyze approaches, methods and instruments of Social Finance (SF) helpful to support Social Enterprises (SEs) localized in some marginal territory of the EU (and especially in Sardinia). The project aims: 1) to contribute to the international academic debate on SF, with a focus on the role of SF for SEs through the analysis of the best practices useful for the improvement of the economic wellbeing; 2) to provide better theoretical and practical solutions, by designing tailored financial instruments for the SEs located in Sardinia with the aim to develop and to test efficient ways to reduce social exclusion and to promote social innovation; 3) to promote a permanent network between the involved parties with the aim to encourage new financial approaches for a more inclusive society. The relevance of this research project is confirmed by: i) the role of SF and SEs in the European agenda, in the academic debate, and in the challenges for financial systems; ii) the need to overcome the limits of the mainstream finance and to conceptualize a new finance approach able to be a good finance for a more inclusive society, iii) the multidisciplinary approach to the field of SF that involves both social innovation and social entrepreneurship. The innovativeness of the project is related to: i) the combined research approach (deductive/inductive) useful for exploratory studies; ii) the international approach to the topic of SF, that will be explored in collaboration with one of the leading international researcher in the field of SF and one of the most prominent researchers in the field of impact finance. The research activities will be developed through: i) the outgoing phase at Waterloo University; ii) the return phase at UNICA (Sardinia/South Italy). The project will allow the construction of a permanent Excellency Laboratory in Sardinia and will promote the development of SF and SEs in such marginal territory.

Keywords: social finance,social entrepreneurship,social innovation,social enterprises,alternative finance
Advanced policies and market support measures for mobilizing solar district heating investments in European target regions and countries (SDHp2m)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Austria,Germany,Austria,Germany,Italy,Germany,Germany,Bulgaria,Belgium,Poland,Sweden,France,France,Denmark
Call: Market uptake of existing and emerging renewable electricity, heating and cooling technologies (H2020-LCE-2015-3, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 2087297.25
EU funding (EUR): 1919297.75
Participants: 16
Project status: CLOSED

SDHp2m stands for ‘Solar District Heating (SDH)’ and actions from ‘Policy to Market’. The project addresses market uptake challenges for a wider use of district heating and cooling systems (DHC) with high shares of RES, specifically the action focuses on the use of large-scale solar thermal plants combined with other RES in DHC systems. The key approach of the project is to develop, improve and implement in 9 participating EU regions advanced policies and support measures for SDH. In 3 focus regions Thuringia (DE), Styria (AT) and Rhone-Alpes (FR) the regulating regional authorities are participating as project partners to ensure a strong implementation capacity within the project. In 6 follower regions from BG, DE, IT, PL, SE the regulating authorities are engaged through letters of commitment. The project activities aim at a direct mobilization of investments in SDH and hence a significant market rollout. The project work program in the participating regions follows a process including 1) strategy and action planning based on a survey, best practices and stakeholder consultation 2) an implementation phase starting at an early project stage and 3) efficient dissemination of the project results at national and international level. Adressed market uptake challenges are: Improved RES DHC policy, better access to plant financing and business models, sustained public acceptance and bridging the gap between policy and market through market support and capacity building. Denmark and Sweden reached already today a high share of RES in DHC and shall be used as a role model for this project. The direct expected outcome and impact of SDHp2m is estimated to an installed or planned new RES DHC capacity and new SDH capacity directly triggered by the project until project end corresponding to a total investment of 350 Mio. € and leading to 1 420 GWh RES heat and cold production per year. A multiple effect is expected in the period after the project and in further EU regions.

Keywords: solar thermal,district heating,solar district heating,policy,financing,support measures
Immune Mechanisms of Necrotic DNA Phagocytosis by Neutrophils: A Role for Integrins (IMPACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2024-01-01
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: SIGNED

Cell death is inherently connected to the existence of multicellular organisms. Our body loses billions of cells a day due to thermal, mechanical or chemical damage in a cell death process with loss of plasma membrane integrity and pro-inflammatory properties known as necrosis. Organisms face necrosis frequently, thus, there must be specific pathways to remove the large amount of cellular debris left behind. In this way, it is no surprise that improper removal of cellular debris, such as DNA, is associated to inflammatory diseases as lupus erythematosus, acute liver injury, atherosclerosis and severe trauma. Removal of necrotic debris is thought to be mediated by phagocytes, although reports showing it are scarce. Neutrophils, a subset of phagocytes, are good candidates for debris removal since they are abundant and quickly recruited to necrotic sites. The means used by neutrophils to identify, internalize and degrade necrotic DNA are currently unknown, thus, the main objective of my project is to understand how neutrophils phagocytose and eliminate necrotic DNA debris. Neutrophils express the DNA-sensing receptor TLR9, which is not a phagocytic receptor. However, they also express very high levels of beta2 integrins such as CD11b/CD18, which act as adhesion molecule and as complement receptor (CR3). The release of necrotic DNA promotes complement activation in vivo through several pathways, therefore, my hypothesis is that neutrophils use beta2 integrins to bind and phagocytose complement-coated necrotic DNA. To assess the role of beta2 integrins, TLR9 and complement in phagocytosis of necrotic DNA by neutrophils, I will combine a novel in vitro method (DNA deposit in coverslip) with an in vivo approach (confocal intravital microscopy). I will also develop novel peptides for DNA labelling and modulation of phagocytosis, which I will use in both models. The findings of this project will directly favor the development of novel therapies for inflammatory diseases.

Keywords: neutrophil,phagocytosis,necrotic debris,integrins,complement receptor,liver,necrosis,inflammation,intravital microscopy
From symptom relief to disease modifying allergy treatment with Glycan-Allergen Immunotherapy (GAIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Netherlands
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The annual increase in prevalence of allergy related diseases develops at an alarming pace worldwide. Responsible disease mechanisms are characterised by unwanted immune responses to substances which do not harm healthy individuals. The allergy therapeutics market is now dominated by symptom alleviating antihistamines, decongestants and corticosteroids. The main patient need is to get cured with a disease modifying medicine instead of the chronic use of symptom relieving products. Allergen-specific Immunotherapy (AIT) attempts to treat the underlying cause by inducing allergen-specific immune tolerance. However, currently used AIT with high doses of extract is not effective enough (only 20% better than placebo), risks severe side effects and requires 5 years of treatment. DC4U is developing a new generation of disease modifying allergy treatment with the potential to replace symptom relieving products and current AIT. We apply a new and unique technology to present allergens to the immune system as being SELF and SAFE, using glycans as endogenous human protein recognition elements. Our lead product, “sia-GP”, is a grass pollen allergy treatment for life long protection, achieved in a short treatment course. DC4U has shown highly promising in-vivo dose-response efficacy results and will further develop this proprietary product up to and including Phase IIa clinical trials. This will be followed by out-licensing to a pharmaceutical company. Effective curative tolerance inducing therapy will contribute to global medical needs and reduction of healthcare costs. In this SME-1 we will elaborate and refine our clinical plans, IPR strategy, market analysis and profitability analysis. Furthermore, we will initialize discussions and negotiations with several possible investors and licensing partners. All will be incorporated in an elaborated European business plan with best suited to out-license sia-GP after Phase IIa clinical trials.

Keywords: allergen specific immunotherapy,grass pollen allergy
Next generation X-ray imaging system (NEXIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Belgium,Sweden,France,France,Netherlands,Netherlands
Call: Photonics KET 2017 (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 9456082.5
EU funding (EUR): 7712152.88
Participants: 10
Project status: CLOSED

A photonics driven breakthrough in image quality and functionality of an interventional X-ray system will allow to perform stroke diagnosis directly in the treatment suite and have a huge impact: enhanced work flow, reduced diagnosis & treatment time (up to 50% time reduction) which will save people’s life and reduce healthcare costs. NEXIS will establish enhanced contrast Cone Beam CT imaging while keeping high spatial resolution for 2D image guidance by an innovative spectral X-ray detector and related image processing (including deep learning). Two new key photonic components will be developed: 1) A thin foil based image sensor which has a (semi-) transparent TFT backplane, so that the photodiode array can receive light from both the top and the bottom side. This (semi-) transparency will be optimised, so that the image sensor can collect light effectively from top and bottom scintillator layers at the same time. 2) A 3D printed pixelated CT-like scintillator with high spatial and temporal resolution to enable fast Cone Beam CT imaging without image artefacts. The usability and applicability of the new spectral NEXIS X-ray system for stroke imaging will be clinically validated in a European top hospital. The project brings together a multidisciplinary consortium, involving the full value chain (photonics R&D, medical system integrator, application owner, supply chain and equipment manufacturing). It will allow key players in the European medical photonics industry to generate sales and stay competitive by providing new X-ray imaging modalities and EU based manufacturing. NEXIS will strengthen European competitiveness by developing a spectral Detector-on-Foil technology that meets the needs of the European and global X-ray image detectors market. NEXIS initiate the transition of standard (black&white) to spectral (colour) X-ray detectors, which will improve performance and functionality of X-ray imaging systems.

Keywords: x ray detector,scintillator,foil based image sensor,spectral analysis,3d image interpretation,clinical validation,thin film
Exploiting the hypoxia response in T cells for Next-Generation Immuno-Oncology (NextGen IO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 1993575.0
EU funding (EUR): 1993575.0
Participants: 1
Project status: SIGNED

NextGen_IO has a core focus on immuno-oncology, specifically on target discovery and drug development, to exploit several opportunities that the hypoxia pathway in T cells offers for the treatment of cancer. It is well recognised that the clinical response of immunotherapies depends on the ability of T-cells to mount an effective effector response, persist in treated patients and avoid exhaustion and toxicities. Several approaches to immunotherapy have shown promise in clinical trials, especially the use of immune checkpoint inhibitors and, more recently, autologous adoptive T-cell therapies. However, current state-of-the-art immunotherapies are only effective in a small fraction of patients, offering a medical need to be addressed in several cancer types. Importantly, the tumor microenvironment has specific features that impact the immune response, including decreased oxygenation, aberrant vascularization and altered nutrient availability; all these influence the success of immunotherapies. During the last 10 years, my research has been focused on elucidating the role of the oxygen sensing machinery in T cell function, and the link of hypoxia-driven metabolism and epigenetic modifications with T cell differentiation into effector and memory T cells within the context of cancer immunotherapy. The current proposal aims to exploit these previous findings with a multi-disciplinary strategy, to deliver several early-stage drug discovery outputs. The main objectives are: 1. Development of a novel small molecule inhibitor to modulate the hypoxic response in T cells. 2. Therapeutic target discovery in T cells, focused on hypoxia-driven epigenetic modifications. 3. Development of hypoxia-inducible molecular switches for adoptive T cell therapy. Successful completion of the project will allow me to further innovate and consolidate my position as a leader in this field, harness this pathway for therapeutic potential and explore potential combinatorial approaches.

Keywords: immunology,oncology,drug discovery,phage display,hypoxia,cell therapy,tumor microenvironment,small molecules,screening,t cells