Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Substitution of fossil Combustion in Industrial high-Temperature processes by ADvanced ELectrical heating technologies (CITADEL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Germany,Slovenia,Spain,Netherlands,Austria,Sweden,Italy
Call: Electrification of high temperature heating systems (Processes4Planet Partnership) (IA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 18256225.5
EU funding (EUR): 13289768.5
Participants: 16
Project status: SIGNED

Effectively combating global warming requires a significant reduction in CO2 emissions. This poses enormous challenges, especially for the energy-intensive process and production industry, as this industry accounts for one third of total energy consumption. What is needed is intelligent electrification across all operational processes. Electrification has such a large potential impact on decarbonisation because it allows clean, renewable electricity to power processes that previously used emissions-intensive technologies (such as gas burners). This means that a process that previously produced high emissions can become absolutely emission-free when powered by renewable energy. The aim of the CITADEL project is to substitute fossil combustion processes with innovative electric technologies, such as electric resistance heating, microwave heating and plasma heating. Five use cases are considered, targeting the production of refractory bricks, glass and copper wires, preheating processes in steel production and the recycling of concrete. For these specific applications, appropriate demonstration plants have to be designed, built, tested close to the process and validated. This is supported by corresponding activities to provide suitable high-temperature materials and tools for instrumentation and effective process control. Challenges regarding a stable energy supply, electrical and thermal load management or intelligent energy management are simulated by means of numerical models. This includes corresponding risk assessments, e.g. with regard to possible time constraints in terms of a continuous power supply and the consequences of supply fluctuations for process safety. All demonstration cases will be evaluated by a life cycle analysis and with regard to the effectiveness in the reduction of greenhouse gases. The impact of the technical solutions developed here for the process industry will be assessed and strategies for scale-up and deployment will be elaborated.

Keywords: electrical resistive heating,microwave heating,plasma heating,refractory firebricks,glass production,steelcasting,copper wire production,concrete recycling
Twinning for excellence in non-invasive brain stimulation in Western Balkans (TWINNIBS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,Germany,Denmark,Italy,Austria
Call: Twinning Western Balkans Special (HORIZON-WIDERA-2021-ACCESS-02, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 1498675.0
EU funding (EUR): 1498674.0
Participants: 6
Project status: SIGNED

TWINNIBS aims to strengthen the Institute for Medical Research - IMR’s research and innovation (R&I) as well as research management and administration capacities and to develop it into a prospective leading partner in international consortia that can attract strategic investments and R&I funding. TWINNIBS will promote interest in neuroscience research in Serbia and the region, and help to advance it, focusing on the multidisciplinary field of non-invasive brain stimulation (NIBS). NIBS is a set of techniques for transcranial (non-invasive) modulation of the activity in the specific brain areas and the large-scale brain networks to which they contribute. This is an innovative approach to neuroscience research and, ultimately, clinical treatment of a wide spectrum of neuropsychiatric conditions. TWNINIBS will be a coordination and support tool for IMR to bring NIBS research in Serbia to a new level by partnering with leading European R&I institutions from Denmark, Italy, Germany, and Austria. TWNNIBS will include a comprehensive set of cooperation and coordination activities to strengthen the scientific and technological capacities of IMR, including short term mobility, virtual and in-person short term expert visits, workshops, and boot-camps. A series of collaborative small-scale projects will be conducted with the personalisation of NIBS as an overarching theme. TWINNIBS will strengthen the IMR research management and administration capacities and foster organizational changes. The Centre for NIBS as well as R&I Project Management Unit will be established within the IMR. TWINNIBS will have a substantial scientific, economic/technological, and societal impact towards outcomes specified in this topic as well as a long-term impact on the R&I in the European space, with a special focus on the Western Balkans region. To realise the full potential of the TWINNIBS project a comprehensive set of communication, dissemination, and exploitation measures will be implemented.

Keywords: non invasive brain stimulation,functional neuroimaging,eeg,neuromodulation,memory,cognitive neuroscience,motor neuroscience,parkinson s disease,dementia,post stroke rehabilitation
Global Migration Justice: Beyond conflicting approaches to migration in international human rights law (MIGJUST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2499812.5
EU funding (EUR): 2499812.5
Participants: 1
Project status: SIGNED

MIGJUST addresses the unacknowledged, fundamental conflict between the European Court of Human Rights, which in its migration case law adopts a sovereignty approach normalising sedentarism, and the Inter-American and African human rights Commission and Court which adopt a human rights approach normalising mobility. This fragmentation of international law also plays out in UN human rights Committees. This fragmentation is not acknowledged in academic work, in which the European approach is assumed to represent the most advanced version of international law. This fragmentation is problematic because it undermines the international character of international law. Legal doctrine overlaps with political theory on migration justice, which focuses on Europe and North America, and does not acknowledge distinct positions developed in Latin American, African and Islamic political theory. MIGJUST ends the hypothesised bias not merely by including Inter-American, African and UN case law and acknowledging their distinct positions; but by in addition linking European, Inter-American, African and UN case law to political theory. MIGJUST will thus produce - a restatement of international human rights law doctrine in the field of migration which includes Inter-American, African and UN case law as well as European case law; - an analysis of the conflicting fundamental positions; - an analysis of how the conflict relates to divergent ideas on migration justice in European, North American, Latino, African and Islamic political theory; - legal doctrinal alternatives, inspired by non-ideal political and legal theory. In doing so, MIGJUST makes - a fundamental academic contribution by ending the assumed European bias; - a fundamental contribution to legal practice by unlocking Inter-American, African and UN case law; - a fundamental contribution to international cooperation between states, IOs and INGOs by making their varying normative positions understandable to each other.

Keywords: migration law
Immune signatures in sentinel lymph nodes to predict distant metastases in malignant melanoma (MelanomaLNs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Malignant melanoma is a deadly disease with a 3% lifetime incidence. Currently, no clinically approved companion diagnostics exist for immunotherapy in melanoma, and sentinel lymph node (sLN) evaluation remains the cornerstone of clinical decision-making. A sensitive, robust, and clinically applicable method for identifying patients at risk of developing metastatic disease is urgently needed. Studies in murine models have shown that lymph nodes (LNs) play a dual role in tumor immunity, both supporting immune activation essential for immunotherapy and paradoxically promoting metastatic spread by inducing systemic tolerance. We hypothesized that sLNs exhibit both pro- and anti-tumorigenic roles, varying across patients and disease stages. In a study of 69 melanoma patients, we applied spatial transcriptomics and proteomics to analyze sLNs, revealing immunological organization patterns associated with these opposing roles. A machine learning model trained on this data predicted distant metastases with 93% and 79% accuracy in involved and uninvolved LNs, respectively, demonstrating strong potential to improve clinical diagnostics. Building on these findings, we propose developing a multiplexed imaging panel to profile immune organization in both primary tumors and lymph nodes to guide patient diagnosis and stratification. This panel will be designed for compatibility with clinical workflows and tested on an independent validation cohort of 500 melanoma patients. To pave the way for commercialization, we will explore the market and value chain, identify and engage with relevant industry players and set up a commercialization plan with the aim of positioning our innovation as the new standard for diagnosing and managing melanoma patients. Our diagnostic assay will enhance treatment decisions by identifying high-risk patients at diagnosis, ensuring they receive timely intervention while sparing low-risk patients from unnecessary, potentially harmful and costly treatments.
Multiparametric Evaluation of osteosarcopeniA diSease Using magnetic Resonance ImagiNG (MEASURING)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 3
Project status: TERMINATED

Osteosarcopenia (OSP) is a recently recognized pathology of aging defined as the co-occurrence of osteopenia/osteoporosis (OP) and sarcopenia (SP) leading to high morbidity, disability, and mortality with an associated tremendous economic burden. There are no approved therapies specifically targeting OSP. It is critical to monitor OSP pathophysiology, progression, and response to therapy holistically by simultaneously measuring effective quantitative biomarkers sensitive to early changes in tissues to provide meaningful information on various mechanisms involved in OSP. As an MSCA fellow, Dr. Barbieri will exploit crucial training at i) the University of Bologna (Host Institution), ii) Rizzoli Orthopedic Institute (Associated Partment linked to the beneficiary), and Stanford University (Associated Partner) during a secondment of 8 months. The excellent network of mentors and participant organizations will ensure the success of the overarching overall objective of the project: to propose technical advancements in Magnetic Resonance Imaging (MRI) sequences, protocols, and processing to overcome the current limitations of MRI-based assessment of cortical and trabecular porosities and to use a multi-parametric approach to study association of bone and muscle quality biomarkers in postmenopausal osteoporotic and osteosarcopenic women. The specifics objectives are (1) to develop a rapid MRI sequence to measure cortical and trabecular porosities, which is not currently feasible, (2) to develop a clinically feasible MRI protocol to map muscle and bone quality, and (3) to assess the association between bone biomarkers and muscle quality biomarkers in OP and OSP women. The excellent technical expertise, paired with training in clinical imaging, will allow Dr. Barbieri to produce: a new MRI sequence to be deployed open access; a new multi-parametric approach to study OSP; information on bone and muscle biomarkers association; and dissemination to crucial target audiences.

Keywords: quantitative mri osteosarcopenia bone imaging muscle imaging bone quality muscle quality magnetic resonance fingerprinting cortical porosity bone marrow adipose tissue myosteatosis
Spin-momentum locking and correlated phenomena in chiral topological materials (ChiralTopMat)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2442508.0
EU funding (EUR): 2442508.0
Participants: 1
Project status: SIGNED

Chiral topological semimetals are a new class of quantum materials at the intersection of structural and electronic chirality. We discovered the first example of this material class three years ago and have since demonstrated that they host new fermionic quasiparticles without analogue in high-energy physics, which carry large and controllable topological charges. ChiralTopMat will go beyond these initial works and aims to discover new extraordinary properties that have only been predicted for these materials but for which experimental evidence remains elusive: 1) A new form of isotropic parallel spin-momentum locking that can be considered the natural counterpart of Rashba spin-orbit coupling, 2) new electronic phases that are both correlated and topological, and 3) interface effects with magnetic materials that could be exploited for new energy-efficient information technology applications. We will achieve these research goals by employing spin- and angle-resolved photoelectron spectroscopy on various energy scales, probing these materials' surface, bulk, and interface electronic structures. Whilst the proposed experiments are challenging, our prior work and recent preliminary results have demonstrated their feasibility. If successful, ChiralTopMat will build on these discoveries to search for structure-property relationships that can be used to control these new phenomena by chemical and structural modification. We envision that this new understanding will be the basis for future devices that exploit chiral topological semimetals for energy-efficient magnetic memory devices, which use multifold fermions for field-free switching of magnets with perpendicular magnetic anisotropy.
PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES (PROTO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Finland,Israel,Romania,Denmark,Italy,Netherlands,Australia
Call: Personalised blueprint of chronic inflammation in health-to-disease transition (HORIZON-HLTH-2022-STAYHLTH-02, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 7447875.25
EU funding (EUR): 7447875.0
Participants: 10
Project status: SIGNED

Osteoarthritis (OA) is the most common form of arthritis worldwide. Chronic low-grade inflammation in the articular environment causes cartilage degeneration at an early disease stage, resulting in chronic pain, disability and loss of independence due to progressive joint destruction. To date, no treatment is available to sustainably combat low-grade inflammation in early-stage OA patients. Biomechanical causes for intra-articular inflammation and OA development have been detected in specific patient groups. The PROTO consortium strives to implement new evidence- and patient-centred treatment strategies for early- and pre-disease stages. For the first time, early-stage knee OA patients will be treated with local PLX-PAD injections, a novel allogeneic cell therapy product with distinct anti-inflammatory capacities that may halt or revert disease progression. Secondly, patients recovering from anterior cruciate ligament reconstructions with pathological gait patterns leading to knee OA, will be treated with a personalized sensor-based digital training intervention. We intend to prevent health to disease transition by restoring physiological movement and reducing joint inflammation. To assess treatment success in early- and pre-stage OA, PROTO gathers scientific and clinical specialists who have genuinely shaped clinical, radiological and biomarker outcome parameters for OA in recent years. This will be the first time that these renowned experts join forces to analyze, stratify and compare fundamentally novel disease modifying treatment strategies for OA in one consortium. PROTO was developed with the help of patient organizations, industry partners and research societies. Restoring physiological joint homeostasis at an early disease stage may be the key to understanding health to disease progression in OA. Targeting this ‘window of opportunity’ will fundamentally change the way OA is treated today and in the future.

Keywords: osteoarthritis,inflammation,joint,atmp,allogeneic,cell therapy,training intervention,sensor based,digital movement training,biomarkers,metabolomics,mechanism of action,prevention
High-Resolution vapour Screener for AUtomatic and faST belongings scanning (SAUST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Strengthened Security Research and Innovation
Action type: Innovation actions
Countries involved: Spain,Italy,France,Greece
Call: Accelerating uptake through open proposals for advanced SME innovation (HORIZON-CL3-2023-SSRI-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 1929276.65
EU funding (EUR): 1426993.65
Participants: 6
Project status: SIGNED

The SAUST project aims to revolutionize aviation security and customs inspections by providing a rapid, non-intrusive and efficient alternative for vapor baggage screening at airports, being the first attempt before the Explosive Vapour Detection (EVD) European Civil Aviation Conference (ECAC) Standard 2 and 3 (hold baggage and cabin baggage) implementation, but with a high focus on drug detection at airport arrivals where the 85% of the drugs are seized in Europe providing new technology to police and customs authorities to increase both the inspection rate, efficiency and drug database including NPS (New Psychoactive Substances). SAUST’s primary objective is to adapt an existing EVD methodology, previously tested under different conditions, mainly explosive screening of air cargo, to create a smaller, more affordable, and faster solution for luggage inspection since the requirements are totally different. The consortium is determined to address this issue through collaboration with industry, mainly SMEs, and police agents as experts who possess an in-depth understanding of the genuine requirements and constraints in customs and airport security. SAUST will develop a versatile, cost-effective, and expeditious screening technology, adapted to luggage screening, that enhances detection capabilities for a wide range of substances, including drugs and explosives, and other illicit substances like tobacco and drug precursors among many others. The ultimate goal is to develop a Technological Readiness Level (TRL) 7 operational prototype, which will bridge critical security and operational gaps in the current screening processes. In addition, the project will provide an analysis of the different scanning options for luggage in order to ensure the airport logistics without disrupting the flow. SAUST border impact has the potential to revolutionize customs inspections, providing technology to activities that currently are mainly done using traditional or manual techniques.

Keywords: customs,nps new psycoactive substances,drugs,aviation security