Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DNA-binding domain Conditioned Precision Genome Editing (DC-PGE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2386205.0
EU funding (EUR): 2386205.0
Participants: 1
Project status: SIGNED

Genome editing in human therapies has the potential to revolutionize modern medicine. With numerous clinical trials underway and the recent approval of the first genome editing therapy, the field is rapidly advancing. However, there is a consensus that clinical genome editing tools must be efficient, precise and safe. Current tools predominantly rely on host cell DNA repair pathways to complete the editing process, which poses a risk for unintended editing events. Host cell DNA repair independent, fully programmable editing tools represent a new class of genome editing technologies, significantly expanding the potential for delivering life-saving therapies to patients. Genome editing tools that fulfil these characteristics are enzymes that recombine DNA. While there has been some success in engineering these enzymes to recognize and act on therapeutically relevant targets, their time-consuming and labour-intensive generation has hindered widespread implementation. DC-PGE aims to address this shortcoming. We have recently demonstrated that recombinase activity can be conditioned by internally fusing a zinc-finger DNA-binding domain into the enzyme's coding sequence, thereby making the enzyme activity contingent on zinc finger DNA binding. This pioneering discovery presents a genuine opportunity to develop next generation and best-in-class genome editing enzymes. DC-PGE aims to i) build a platform to apply DNA-binding conditioned precision genome editing to DNA-recombining enzymes, ii) develop a pan-recombinase system for immediate targeting of virtually any genomic sequence and iii) apply the technology to correct the genetic cause of MECP2 duplication syndrome at nucleotide precision. DC-PGE will serve as a foundation for advancing innovative treatments and improving patient outcomes. Our unique approach lies in combining different disciplines and cutting-edge technologies with the potential to transform the field of genome editing and elevate it to the next level.

Keywords: personalized medicine,directed molecular evolution,bioengineering
A unique valve repair technology to treat Aortic Regurgitation (Cusper)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Heart valve insufficiency, characterized by blood leakage due to a malfunctioning valve, significantly impacts cardiac function. Aortic Regurgitation (AR) occurs when the aortic valve fails to close properly, causing blood to flow back into the left ventricle during diastole, the heart's relaxation phase. This backflow results from structural changes that prevent proper leaflet closure, creating a central jet of regurgitated blood. AR is the third most common valvular pathology, affecting approximately 3.7 million people in the EU and about 2.7 million in the US. This severe and life-threatening condition is considered irreversible without invasive surgical intervention. Unfortunately, 75% of patients with moderate to severe AR are unsuitable for surgery, leading to frequent hospitalizations and progressive worsening of their condition. The absence of a percutaneous, or minimally invasive, solution for AR means patients must endure the substantial risks of traditional open-heart surgeries and valve replacements, which have high morbidity and mortality rates, especially for patients with comorbidities or advanced age. In response to this need, the Cusper device has been developed as the first minimally invasive repair solution for valve insufficiency that does not involve valve replacement. This innovative device functions as an artificial cusp attached to the native aortic valve. Preclinical studies have shown that the Cusper device can potentially reduce regurgitation by 80% and alleviate associated symptoms, offering significant clinical benefits. The clinical validation phase is the next step, with a comprehensive plan developed in collaboration with key opinion leaders in the field. This phase is crucial for confirming the efficacy and safety of the Cusper device in a clinical setting, bringing us closer to offering this groundbreaking solution to patients suffering from AR.

Keywords: aortic regurgitation cardiovascular aortic insufficiency valvular diseases surgery surgical aortic valve repair valve repair transcatheter
Finance and Innovation to couple Negative emissions and sustainable Development (FIND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499825.0
EU funding (EUR): 1499825.0
Participants: 2
Project status: SIGNED

The FIND project will develop an innovative framework to assess the feasibility and social desirability of limiting global warming through the diffusion of negative emission technologies. Current global climate action is deeply insufficient to deliver the objectives of the Paris Agreement and containing global warming to 1.5 °C will likely require the deployment of carbon dioxide removals. However, the technologies to sequestrate and store carbon from the atmosphere are currently immature, risky, and highly questioned. Understanding the effective diffusion potential of carbon removal methods and their socioeconomic and environmental impacts is pivotal to design future climate action. The FIND project aims to ensure that negative emission technologies act as an enabler, not a barrier, of long-run sustainable development. It brings together different disciplines – namely, climate science, economics, innovation studies, climate finance, integrated assessment, and agent-based modelling - in a coherent and synergic whole. FIND is designed to provide breakthrough evidence about two crucial and under-investigated aspects of carbon removal solutions: (i) how their techno-economic paradigms evolve and relate to the broader technological landscape, and (ii) how immature and uncertain technologies can be financed to provide social value rather than speculative interest. By combing innovation, finance, and political economy into a quantitative theory of carbon removal operationalization unfolding at global scale, FIND will expand the state-of-the-art in climate-energy-economy modelling and reassess decarbonization pathways. The project will evaluate climate and non-climate policies to create robust, no-regret policy portfolios supporting a rapid and sustainable path to a net-zero society. FIND will be of high relevance for public policy and civil society, especially considering Europe’s commitment to reach carbon neutrality by 2050 while spurring green and inclusive growth.

Keywords: negative emission technologies sustainable development innovation technological diffusion climate finance integrated assessment modelling
Role and modulation of Zinc-finger antiviral protein and antiviral Regnase-1-like endonucleases (EXPL ANTIVIR ENDONUC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

The human zinc finger antiviral protein (ZAP) is capable of inhibiting several major human pathogens, including Influenza A virus and SARS-CoV-2. ZAP specifically targets CpG dinucleotides in RNAs and might be one of the reasons why CpGs are strongly suppressed in the human genome. Successful viruses, such as HIV-1 and SARS-CoV-2, mimic human CpG suppression to partially evade the inhibitory effects of ZAP. However, especially under conditions of infection or inflammation when ZAP is expressed at high levels, it inhibits both CpG containing viral as well as cellular RNAs. Importantly, ZAP itself does not possess RNAse activity and is dependent on cofactors, such as KHNYN, to destroy viral RNAs. KHNYN is tightly regulated and inactivated by MALT-1, a cellular protease representing an important target in cancer immunotherapies. Although some progress has been made, the identity of ZAP cofactors as well as their mechanism(s) of action and therapeutic potential are poorly understood. This proposal aims to combine the expertise of the applicant (mechanistic studies of ZAP and RNA-targeting factors) and the host (respiratory viruses and antiviral drug development) to define how ZAP-dependent and independent antiviral endonucleases restrict major respiratory viral pathogens. In addition, it will be examined whether MALT-1 inhibitors that are currently in clinical trials against cancers allow to enhance and maintain the antiviral activity of ZAP and its cofactors thus offering prospects for the treatment of respiratory infections. Finally, potential side-effects on cellular RNAs and their impact on immune signalling, cell activation and infection outcome will be determined. The project will combine innovative CRISPR/Cas9 genome editing, in vitro virus infection platforms, novel functional assays and state-of-the-art deep sequencing technologies to significantly advance the knowledge on antiviral RNAses and to clarify whether they can be strengthened for antiviral therapy.

Keywords: intrinsic immunity antiviral restriction factors zap endonucleases respiratory viruses
Multilingual perspective in Gender and Language. Realization and processing of gender in different Romance languages: an interdisciplinary approach for the field of education and public communication (MultiLingualGender)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Spain,Argentina,Brazil
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 253000.0
EU funding (EUR): 253000.0
Participants: 5
Project status: SIGNED

There are various lines of study on gender in natural languages, which have been approached from varied perspectives; not only grammatical but also lexicographic, pragmatic, discursive, sociolinguistic and psycholinguistic. Spanish, Portuguese and Italian are all considered as languages with grammatical gender, and binary gender paradigms. One of the studied phenomena is whether for speakers of languages ​​with obligatory gender markings and binary gender paradigms, the generic interpretation bias is no longer as arbitrary as some traditional grammatical studies assume. Another key problem ​​is the interpretation of the generic masculine. In Romance languages such as Spanish, Italian, Portuguese, the masculine gender can also function as a generic, that is, to refer to entities with different genders, but the univocal reference as a generic has been questioned from sociolinguistic and pragmatic approaches.Within this framework of gender binarism and masculinizing bias, some linguistic communities have begun to use and disseminate various gender-inclusive forms as [-x], [-e], [-ə], [-u], [*]. Currently, the discussion focuses on the notions of gender (rather than sex) and binarism, in line with current advances and discussions on sex-gender diversities and dissidences. In grammatical gender languages, the most recent proposal is focused on the morphological gender markings that nouns carry and are projected to other words due to agreement requirements. In this Project we proposed to develop a line of interdisciplinary and multilingual studies that allows us to reflect and deepen our knowledge about the complex relationships between morphosyntactic aspects of the grammatical gender category in Romance languages, associated sex-gender representations, psycholinguistic processing of gender, construction and circulation of meanings linked to gender identities and the phenomenon of variation in the uses of each language in different communities of speakers.

Keywords: gender morphology,multilingualism,romance languages,gender stereotypes
Exact Results from Broken Symmetries (BrokenSymmetries)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Symmetries serve as our main guide in studying physical phenomena. The more symmetric a system is, the more constrained are its degrees of freedom and the better prospects we have to understand and solve it. Significant progress has been achieved in the study of theories with high amounts of symmetry in the last decades. Supersymmetry and conformal invariance are the main reasons why the beautiful idea of holography materialised into the AdS/CFT correspondence and the discovery of hidden symmetries (integrability) in gauge theories was possible. Thanks to supersymmetry, modern mathematical techniques allowed the evaluation of the otherwise unfathomable path integral and the comprehensive study of a long list of physical observables. Finally, the successful revival of the conformal Bootstrap program is based on conformal invariance. These breakthroughs are, unfortunately, applicable only to theories with unrealistic amounts of symmetry. BrokenSymmetries will break this impasse by applying the aforementioned ideas to more realistic theories, where some of the supersymmetry and/or conformal invariance are broken. The key innovation of BrokenSymmetries is to still make use of a broken symmetry. Symmetries are captured by Ward identities which we can still derive in various cases of symmetry breaking. Broken symmetries also imply powerful non-perturbative relations that observables obey. We will combine these with the developments mentioned above, producing novel exact results. Our approach will give a handle on otherwise insoluble problems. The objectives of BrokenSymmetries are to obtain exact results while breaking: 1) conformal invariance spontaneously, keeping supersymmetry intact; 2) supersymmetry explicitly, keeping conformal invariance intact; 3) both supersymmetry and conformal invariance turning on the temperature; 4) (super)symmetry generators in the context of integrability, which get upgraded to quantum groups' generators.

Keywords: exact results,ads cft,cft,integrability,localization,agt,bootstrap,conformal manifold
At the Crossroads of History, Industry, and Technology: Olive Oil Production in the Eastern Mediterranean in the Late Nineteenth Century (1839-1914) (OliMed)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 169326.72
EU funding (EUR): 169326.72
Participants: 1
Project status: CLOSED

The last twenty years have witnessed an increase in the production of olive oil The last twenty years have witnessed an increase in the production of olive oil in the Mediterranean as a consequence of the campaigns of the International Olive Oil Council. The proposed research aims at bringing forth an original contribution to this dynamic field by adopting a comparative perspective that concentrates on the history of olive oil production in several most important olive and olive oil producing regions of the Eastern Mediterranean. The analysis will focus on the factories and mills built in the late nineteenth century in the islands of Crete and Mytilini (in Greece) and the areas of Ayvalık, Edremit, and Izmir, in Turkey. The historical examination of these “factories” aims to go beyond the World-Systems theory that focuses on the industrial decline in this region with the advent of European industrial products. Instead, this research proposes to evaluate the modalities and limits of incorporation into the world economy by concentrating on the production of olive oil in terms of adaptability, complementarity, and rivalry within the economic structure of the period. The interdisciplinary approach at the crossroads of history, economy, and technology will open the way for a more accurate evaluation of the role of industrial and technological developments in the economic life of these regions and their influence on the social life. The comparative dimension integrating different olive oil producing regions of the Eastern Mediterranean will make possible an evaluation of the positions of these regions within the world economic system and the Ottoman central government’s policies to control the economy of these regions. Thus, by focusing on the olive oil production in Eastern Mediterranean, the proposed study aims to bring an original contribution by highlighting the growing role of the inner dynamics of the Eastern Mediterranean in economic transformation.

Keywords: eastern mediterranean,olive oil,industry,technology
EcoXtract® project aims to free the human food chain from hexane (ECOXTRACT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

EcoXtract® is the company that will free the human food chain from hexane. Our ambition is to bring a safe and sustainable by design extraction solution to replace petroleum-based neurotoxic hexane for the production of nature-based ingredients, edible oils and plant-based proteins for food and feed, and personal care markets.

Keywords: food,feed,hexane,extraction,public health
Lifecycle extension of salvaged wooden materials through reuse in dowel-laminated timber (EcoDLT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Slovenia
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 155559.36
EU funding (EUR): 155559.36
Participants: 2
Project status: SIGNED

Reusing salvaged timber in new applications can make an important contribution to circular economy. However, currently the reuse of such materials is limited, especially in structural applications. One reason is the lack of demands from the wood sector due to the absence of standard grading procedures and other issues related to e.g., shape irregularities, service damages, dimensions limitation, and degraded properties, which will require costly, significant processing that makes salvaged timber less profitable. This project will demonstrate how a fit-for-purpose approach can be implemented in a practical manner to reuse salvaged timber in structural applications. The target application is in dowel-laminated timber (here: EcoDLT) floor panels. In EcoDLT, salvaged timber will be reused in combination with new (raw) timber using a new fabrication method that will not require significant processing or gluing. This can reduce the processing costs, which can make salvaged timber more profitable and more attractive for the wood sector. The project will first evaluate the current state of salvaged timber resources in Slovenia using resource inventory. A resource classification method will be then established using which the reusability and profitability of reusing each resource can be determined (objective 1). In the next stage, the concept and fabrication method of EcoDLT will be developed experimentally and its structural properties will be examined (objective 2). Analytical models will then be developed for predicting the structural properties of EcoDLT using a new ‘well-known weak points’ concept, which will consider certain strength-reducing features of salvaged timber that are not represented in the existing models (objective 3). The project will contribute substantially to the EU’s circular economy goals and will lead to breakthrough innovation in wood cascading and analytical analysis of mass laminated timber elements with complex configurations.

Keywords: salvaged timber,reuse,dowel laminated timber,low cost manufacturing,pre stressing,wooden connectors,circular economy,mechanical testing,analytical analysis