Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
“Quantitative analysis of the molecular and cellular behaviors associated with cardiac valve morphogenesis in pathological and regenerative contexts” (ZEBRA-VALVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Cardiovascular diseases (CVDs) take a huge toll on the world population. An estimated 19 million people died from CVDs in 2010, representing 30% of all global deaths. Abnormal blood circulation is widely recognized as a cardiovascular risk factor and mechanotransduction has been shown to trigger pathologies such as atherosclerosis1, cardiomyopathies2 and valvulopathies3. Mechanotransduction is the conversion of a mechanical stimulus into a biological response. It is central to the coordination between mechanical forces generated by flowing blood and heart valve morphogenesis. In the developing heart, the heartbeat and the blood flow signal to endocardial cell (EdC) progenitors through mechanosensitive proteins which in turn modulate the genetic program controlling cardiogenesis4. It is essential to determine how mechanical forces control pathway activation and morphogenesis in vivo because the mechanical stimuli experienced by EdCs are too complex to be faithfully reproduced in vitro. This timely proposal aims to uncover the cellular molecular programs activated in EdCs in response to mechanical forces during normal heart valve development and address their potential function in valve regeneration. My hypothesis is that endocardial mechanotransduction and mechanical forces are not only key for the morphogenesis of the valve, but also for their maintenance and repair. Specifically I aim to investigate the spatial and temporal nature of endocardial cellular behaviors necessary for cardiac valve morphogenesis in normal, pathological and regenerative contexts.

Keywords: cardiac valves,valvulogenesis,mechanotransduction
Republics on the Stage of Kings. Representing Republican State Power in the Europe of Absolute Monarchies (late 16th - early 18th century) (RISK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1452210.0
EU funding (EUR): 1452210.0
Participants: 1
Project status: SIGNED

RISK investigates Republican pageantry and encomiastic production from late 16th- to early 18th-century Europe, with regard to the Italian city-states that maintained their independence throughout this timeframe (Venice, Genoa, Lucca), the Republic of Ragusa (today in southernmost Croatia) and the Dutch Republic. A multidisciplinary corpus of sources is taken into account, including: praising texts celebrating Republican values; paintings and engravings displaying civic rituals, or portraying mythological prosopopoeias of the Republic; and written accounts of public ceremonies, such as the election of the Doge or the triumph performed after a victorious campaign. RISK provides the first comprehensive overview of these Republican displays of state power in an era - the so-called Ancien Régime - that is generally perceived to have been marked by the rise of a unique political model, i.e. the absolute monarchy. By comparing the representation of kingship and the staging of the Republican state, RISK analyses to what extent the absolutist framework influences the display of ideals such as freedom, equality, and the common good. The goal is to comprehend how the rhetorical devices of Baroque culture extoll a power that does not apply to someone (the King), but rather to something (the Republic and Republican virtues). RISK is expected to lead to a paradigm shift in our understanding of early modern cultural policy and propaganda. Indeed, Ancien Régime republicanism offers a repertoire of images and concepts that embodies an alternative mode of thinking about the state. This legacy allows us to challenge the perceived idea of a Janus-faced early modern Europe, where a series of binary oppositions would supposedly herald the transition towards modern democracy (monarchy versus republic, absolutism versus Enlightenment, court versus public sphere). RISK undermines these juxtapositions, as it highlights the richness and the plurality of our cultural heritage.

Keywords: iconology,representation of power,cultural history,early modern republicanism,baroque propaganda,court poetry,encomiastic literature,commissioned cycles of paintings,festival books
Prosumer Flexibility Services for Smart Grid Management (Flex4Grid)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Slovenia,Slovenia,Slovakia,Finland
Call: Distribution grid and retail market (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2018-03-31
Duration (months): 39.0
Total project cost (EUR): 3120203.09
EU funding (EUR): 2680253.0
Participants: 9
Project status: CLOSED

The advent of distributed power sources, such as photovoltaics and windmill plants, gave rise to energy prosumers (producers-consumers), which generate and consume electrical energy. Energy demand and energy generation by prosumers are volatile and can impact the grid infrastructure and stakeholders, but they can be flexibly adapted to thwart those impacts. Flex4Grid aims at creating an open data and service framework that enables a novel concept of managing flexibility of prosumer demand and generation, utilising cloud computing for power grid management and, opening DSO infrastructure for aggregator services. The system will be built up from existing ICT components developed by the consortium partners over many years in research projects on IoT and Cloud computing. This high maturity allows Flex4Grid to aim for a system prototype of TRL 7 which guarantees a maximum impact and competitiveness in the area of the smart grid challenge. The Flex4Grid system will include a) a data cloud service with anonymised interface and advanced security and privacy mechanisms for data exchange and service management, b) prosumer generation and demand flexibility, and c) a more viable business model to accelerate the deployment. The major innovations are a) opening the market for new entrants by secure and privacy enabling third party cloud data and energy management services, b) actionable common and multilevel data management and analytics services for Smart Grids, and c) the use of co-creation to bring end users into the value creation process. System validation will be carried out in real-world pilots in three live electricity networks with different scenarios ranging from deployment during smart meter rollout and retrofitting to large scale operation and federated demonstration of multi-site pilots.

Keywords: prosumer flexibility management,demand response,smart grid management
His-Li mouse, the unique humanized mouse model resembling human liver and immune systems (His-Li mouse)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Preclinical toxicology evaluation is the most critical step in pharmaceutical drug development, representing about 21.2% of the total drug development costs. About 70% of drug development programs fail due to toxicity or unexpected issues in Absorption, Distribution, Metabolism, and Excretion (ADME) at Phase 1 validation on humans. The main problem lies on the lack of accurate and reliable pre-clinical mouse models: in fact, current models fail to reflect human liver physiology, and often lead to the development of drugs that are safe in mice, and reveal unpredictably toxic or even deadly in humans. Strikingly, only 13.8% of drugs development programs are finally approved. The development of a single drug requires at least 1,000 iterations, accounting for about €10 M in total, and procedures that can take up to 10 years. TransCure bioServices offers the His-Li-mouse, a humanized mouse model for pre-clinical drug testing, based on the unique combination of the humanized liver and immune systems. His-Li-mouse is the first pre-clinical model that perfectly reflects the human liver physiology and immune response, thus representing a unique tool to perform reliable pre-clinical safety and efficacy tests of drugs. His-Li-mouse enables to reduce the failure rate observed when reaching the clinical trials and to subsequently eliminate unnecessary and costly experimental iterations. This will benefit to the global population, as a more efficient drug development process will potentially save millions of lives or improve its quality by enabling the faster discovery of breakthrough pharmaceuticals. During the phase 1 feasibility study, TransCure will establish a sound go-to-market strategy and supply chain, and will draft further development plans. During the innovation project, TransCure will optimise the humanization protocol, scale-up mice generation and validate the His-Li-mouse pre-clinical service with prospect customers.

Keywords: humanized mouse model,drug development,pre clinical,liver disease,toxicology
Oncometabolitic control of tumor growth and epileptogenesis in IDH mutated gliomas: D2HG signaling mechanism. (GliomaSignals)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2026-05-31
Duration (months): 72.0
Total project cost (EUR): 1875135.0
EU funding (EUR): 1875135.0
Participants: 1
Project status: SIGNED

Dysregulated growth processes of gliomas interact with pro-epileptic plasticity of brain circuits in such a way that the excitatory transmitter glutamate promotes autocrine tumor invasion as well as epileptic synchrony in surrounding cortical regions. Most low-grade gliomas are associated with mutations of Isocitrate DesHydrogenase (IDH) genes which lead to an excess of the oncometabolite D-2-Hydroxyglutarate (D2HG). With a structure mimicking glutamate, D2HG is thought to participate in both epileptogenic and oncologic processes. Importantly, while epileptic activity is accentuated, tumor prognosis is improved in affected people. My preliminary data now suggest a dual function for D2HG, acting as a glutamatergic agonist at high levels, but as an antagonist in the presence of glutamate. Solving this paradox will be a step forward in glioma science. The GliomasSignals project will examine the role of D2HG in the neurobiology of gliomas bringing electrophysiology concepts and tools to neuro-oncology, seeking to transform our understanding. It seeks to better understand how D2HG modulates glutamatergic signaling, affects neuronal excitability and tumor growth, and to detect the extent to which tumor infiltration colocalizes with epileptic remodeling. In vivo and in vitro work mostly on human tissue will aim at: 1- Map biomarkers of epileptic activity / tumor infiltration by cortical recordings during surgery using unique next generation Neurogrid electrodes. 2- Correlate D2HG levels, glutamate concentrations and tumor infiltration with recordings in peritumoral cortex at an unprecedented resolution. 3- Identify D2HG effects on glutamate signaling in human tissue slices producing epileptic activities and in a rodent model. 4- Explore D2HG long-term effects on epileptic activity and tumor growth / infiltration in co-cultures of tumors with surrounding peritumoral cortex by exploiting our unique capabilities for long-term human cortex organotypic cultures.

Keywords: glioma,epilepsy,electrophysiology,human tissue,glutamate
Mass Casualty Ventilation Monitoring (AIRMED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 1657575.25
EU funding (EUR): 1000000.0
Participants: 1
Project status: SIGNED

The viral pandemic we are facing (COVID-19) has pointed out that in the wake of a virulent flu strain, patients with survivable illness will die from lack of resources unless more ventilators are made available. Hospitals have almost no reserve ventilators to respond to disaster or pandemic. Critical-care ventilators are complex and their high cost makes it impossible to stockpile them, so simple, low-cost, ventilators are the only suitable solution at the moment. Because of their technical simplicity, the performance of such ventilator is highly impacted by patient’s pulmonary characteristics which could cause either hypoventilation or hyperventilation resulting in severe lung injuries and death. The important difference between these disaster ventilators and advanced emergency ventilators is the absence of alarms for undesirable events (disconnection, ventilation failure, O2 consumption…), which is, of course, a major patient-safety issue. The use of such ventilators would therefore be strongly conditioned by the possibility to monitor ventilation parameters. Archeon has recently developed a medical device that provides caregivers with ventilation monitoring and real-time feedback on the quality of ventilation given to cardiac arrest patients. The system has been tested successfully in different mass casualty incident simulation scenario and has proven a drastic improvement of ventilation quality (75%). The aim is now to develop and implement the first independent monitoring system dedicated to mechanical ventilation at a very low-cost so that it could massively equip every hospital and care centre in the event of mass casualty incident or viral pandemic. This technology could save a very large number of lives as was demonstrated that avoiding hyperventilation decreases mortality from 34.1% to 19.6% in the intensive care unit. With the necessary resources, the project can be completed very quickly as Archeon already has all the know-how and technology available.

Keywords: covid 19,mechanical ventilation,public health,artificial intelligence
Converged Heterogeneous Advanced 5G Cloud-RAN Architecture for Intelligent and Secure Media Access (CHARISMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Israel,Greece,Greece,Slovenia,France,United Kingdom,Portugal,Luxembourg
Call: Advanced 5G Network Infrastructure for the Future Internet (H2020-ICT-2014-2, 2014)
Start date: 2015-07-01
End date: 2017-12-31
Duration (months): 30.0
Total project cost (EUR): 5892245.0
EU funding (EUR): 5892245.0
Participants: 14
Project status: CLOSED

CHARISMA proposes an intelligent hierarchical routing and paravirtualised architecture that unites two important concepts: devolved offload with shortest path nearest to end-users and an end-to-end security service chain via virtualized open access physical layer security (PLS). The CHARISMA architecture meets the goals of low-latency (<1ms) and security required for future converged wireless/wireline advanced 5G networking. This provides a cloud infrastructure platform with increased spectral and energy efficiency and enhanced performance targeting the identified needs for 1000-fold increased mobile data volume, 10-100 times higher data rates, 10-100 times more connected devices and 5x reduced latency. Fully aligned and committed to the 5G-PPP principles and KPIs, the CHARISMA proposal brings together 10G-wireless (via mm-wave/60-GHz & free-space optics, FSO) access and 100G fixed optical (OFDM-PON) solutions through an intelligent cloud radio-access-network (C-RAN) and intelligent radio remote head (RRH) platform with IPv6 Trust Node routing featuring very low-latency for the traffic management. Low-cost Ethernet is used across front- and backhaul, and end-user equipment (vCPE), and intelligence distributed across the back-, front-hauls, and perimetric data transports. Ad-hoc mobile device interconnectivities (D2D, D2I, C2C etc.), content delivery network (CDN) and mobile distributed caching (MDC) offer an energy-efficient (better than x20 improvement possible) information-centric networking (ICN) architecture. Furthermore, caching will provide efficient utilization of scarce resources by early aggregating data or/and by executing communication locally. The CHARISMA approach will benefit user experiences with ground-breaking low-latency services, high-bandwidth, and mobile cloud resilient network security.

Keywords: low latency,v security,converges open access
Investigating the structural role of the Hepatitis B virus core protein C-terminal domain in assembly and maturation using solid-state NMR (HBVssNMR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 143603.35
Participants: 1
Project status: CLOSED

We will seek in this project to reveal structural and dynamic features of the C-terminal domain (CTD) of the Hepatitis B virus (HBV) core protein which encapsidates the viral genome. Each year, over 750,000 deaths are due to serious liver diseases caused by chronic HBV infection. Hepatitis B is, despite the availability of a vaccine, still a major health problem. The HBV virus particle is composed of an outer lipid-protein envelope and a core protein of 20 kDa that self-assembles into icosahedral nucleocapsids. The nucleocapsid encloses the pregenomic RNA (pgRNA) that is then reverse-transcribed into DNA by the viral polymerase (Pol). During pgRNA encapsidation, the CTD is thought to interact with the RNA. Despite the essential role played by the CTD in the regulation of the viral life cycle through various conformational states and phosphorylation patterns, it escapes today to classical structural biology approaches due to its dynamic nature. We will use solid-state NMR to bring new insights into the precise conformation and localization of the CTD along various steps of the viral life cycle. Sample preparation protocols of the core protein have recently been established by the applicant in the host laboratory using bacterial expression systems. The first NMR spectra of the nucleocapsid look highly promising. Further experiments will be recorded to assign the resonances and identify the CTD signals. Different phosphorylation states and binding partners, as the pgRNA, will be explored. Finally, paramagnetic tags will be used to obtain information about the positioning of the CTD. Our work shall contribute to expand the present molecular description of the HBV life cycle to include the role of the CTD. Our results will help to understand, and ultimately to target, its central role in HBV infection.

Keywords: solid state nmr,structure,nucleocapsid,hepatitis b virus
Sustainability Assessment based on Decision Aiding (SAbDA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Poland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-26
End date: 2021-09-25
Duration (months): 36.0
Total project cost (EUR): 227361.6
EU funding (EUR): 227361.6
Participants: 2
Project status: CLOSED

There is a pressing need for clear and understandable information regarding the sustainability of products, companies and policies. To achieve this, one of the main priorities for the European Commission is strengthening the integration of Sustainable Development (SD) principles into the policy-making processes. For this to occur there is an impelling need for: (i) enhancing the economic profitability of businesses employing the principles of a circular economy; (ii) providing consumers with a comprehensive understanding of the impacts of products from a sustainability perspective, including environmental (e.g. energy consumption), economic (e.g. raw materials costs) and social considerations (e.g. workers’ safety); and (iii) accounting for limited availability of primary resources. These objectives can be achieved if robust evaluations for the sustainability of products, companies and policies are conducted and communicated. The premier tool to support the achievement of these objectives is Sustainability Assessment (SA). Due to the importance of such societal challenges, an increasing number of criteria have been proposed to conduct a SA. A main challenge is the ability to communicate effectively the sustainability of the target alternatives in an easily understandable format, being as a score of performance, a preference class, or a ranking. Multiple Criteria Decision Aiding (MCDA) is an excellent approach to achieving these goals. Frameworks applying MCDA to SA have been proposed, but they are tailored to a set of MCDA methods and only support a limited typology of data and preference elicitation techniques. This SAbDA project will tackle these shortcomings by introducing a step-wise framework to support the development of SAs and selection of the most relevant MCDA method(s). This will include assessing the MCDA methods currently available and developing new ones, including those for evaluations at the micro (product) and meso (organization, region) levels.

Keywords: sustainability assessment,decision support,decision analysis,stakeholders involvement,sustainable development,knowledge engineering,policy,decision making,european commission,european union