Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting kidney fibrosis by a novel myofibroblast specific small molecule inhibitor (FibroTarg)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Chronic kidney disease (CKD) is a progressive disease that is prevalent in 10% of the developed world and develops as a result of diabetes mellitus, hypertension, glomerulonephritis or acute kidney injury. Over time, CKD can progress to end-stage renal disease (ESRD); a condition that can only be treated through hemodialysis or kidney transplantation, posing a severe medical, societal and economic challenge. Fibrosis is recognized as a key pathological mechanism in CKD, responsible for slowly destroying the tissue architecture of the kidney. Current therapies for CKD alleviate symptoms of the disease by controlling hypertension and hyperglycemia, but, while fibrosis is as a promising therapeutic target, no antifibrotic therapy for the kidney have reached the clinic. Hence, there is an urgent need for disease-modifying and curative treatments that can halt fibrosis. In FibroTarg we will assess the technical and commercial feasibility of Fibrolisine, a first-of-its-kind anti-fibrotic drug candidate, for the treatment of CKD. Our preliminary data has confirmed a unique expression profile of our therapeutic target and reduced fibrosis onset in in vivo knockout models without side-effects after kidney injury. Hence, Fibrolisine is expected to target the process of fibrogenesis and halt the progression to ESRD in early-stage CKD patients. Through the activities in FibroTarg project, we aim to demonstrate the antifibrotic potential of Fibrolisine in advanced human kidney fibrosis organoid models and in vivo models of kidney injury. Concurrently, we will investigate the commercial potential of Fibrolisine by analyzing the commercial landscape and develop an initial commercialization strategy.
Design of Catalytic Processes with Deep Eutectic Solvents (DECADES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Austria,Spain,Netherlands,United Kingdom,Italy
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2856181.37
EU funding (EUR): 2626934.4
Participants: 17
Project status: SIGNED

The DECADES doctoral network will conduct innovative research while training 10 PhD candidates with the interdisciplinary skills, intersectoral experience and entrepreneurial mindset to implement sustainability concepts in the European Biotech Sector, making a significant contribution to achieve the GREEN DEAL objectives of European Union. DECADES will focus on solvents as central part of the sustainability of biotechnological processes. Deep Eutectic Solvents (DESs) are biobased and biodegradable solvents that hold potential to revolutionize the chemistry of the 21st century. Aim is to apply these 'Safe and Sustainable-by-Design' solvents to increase efficiency and sustainability of industrial biocatalysis. DECADES will bring to fruition the benefits of DESs by bridging current proof-of-concept knowledge from academia to industrial applications, and by a holistic exploitation considering solvent design and application through multiple aspects (catalyst, substrate, environmental impact) and along the whole pipeline (upstream/downstream). DECADES will greatly contribute to the transition to synthetic processes based on circular economy, by establishing biocatalytic synthesis of several value-added (bio-based) chemicals. DECADES emphasizes particularly the engineering of multi-step catalytic reactions in DESs. The scientific approach of DECADES is highly interdisciplinary and brings together biology, chemistry and process engineering to achieve significantly increased productivities and diminished waste. Commercial relevant processes will be up-scaled together with industry; for which continuous processing will be of main focus. 10 Non-academic partners ranging from high-tech SMEs to large producing companies and 6 academic institutions offer an intersectoral and interdisciplinary environment to provide 10 PhD candidates with outstanding employability profiles for the European Biotech Sector, both in academia and in industry.

Keywords: sustainable solvents for catalysis protein engineering biocatalytic cascades process engineering downstream processing
'New Images of Man'? Remaking Art in Postwar France, 1944–1968 (REMAKING)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

This project is designed to address the longstanding masculinist interpretation of visual art in the decades immediately following the WWII in Europe. Since the 1950s, the aesthetics of art in this period – of rough surfaces, violence, and gestural grandeur – has been interpreted in essentially masculine terms as interrogating ‘man’. Yet women sculptors and painters were among the most important artistic innovators shaping new directions for European modern art. This project examines how women artists in this period shaped new artistic practices and artistic identities in a transformed postwar environment. By developing new multidisciplinary historical and theoretical frameworks that combine feminist, queer, and ecological approaches, it seeks to forge a new interpretation of postwar art-making that no longer perpetuates the myth of the lone male hero. The project will be undertaken under under the supervision of Elissa Mailänder, at the Sciences Po Centre for History (CHSP), whose connections, experience, and research expertise on gender, violence, and WWII, are acutely relevant. The CHSP will also offer expert interlocutors for the project including world-leading art historian on post-WWII France, Laurence Bertrand Dorléac. Since my aim is to help change widespread cultural perceptions, a key project objective is to communicate results widely. I will produce open-access research articles, an online essay, an exhibition, a major conference open to the public, and an eventual monograph. Building on current public interest in modern women artists, and my proven communication skills, most outputs will be relevant to both public and scientific audiences. The action is also designed to strengthen a range of research and transferable skills, and to reinforce the interdisciplinarity of my research. It will establish me as an international researcher and communicator of important themes in modern art and culture, enabling ongoing knowledge-exchange across the ERA.

Keywords: modern art,postwar europe,french occupation,women artists,twentieth century france
RM Framework: Creating a European Framework for Research Management Training and Networking (RM Framework)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Belgium,Germany,Hungary,Portugal,Spain,Romania,Czechia,Italy
Call: Support for the professionalisation of research management (HORIZON-WIDERA-2024-ERA-01, 2024)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 1009956.25
EU funding (EUR): 1000000.0
Participants: 17
Project status: SIGNED

RM Framework endeavors to strongly enhance research management within the ERA and beyond by fostering clarity, interoperability, and sustainability in the diverse RM landscape. This ambitious initiative aims to engage diverse stakeholders by establishing a common frame of reference for RM by involving national clusters, training providers, funding agencies, ministries and other RM actors and networks. The project looks to tailor training approaches to meet the varied needs of research managers across Europe by utilising extensive networks to gather diverse perspectives and insights to tailor training approaches to offer comprehensive training, from general European-level programs to specialised initiatives. The project will explore various training methods, including community-based, informal, and formal university alliances. This will all be achieved whilst also acknowledging national and local differences by bringing together pilot testers from 9 countries (ensuring inclusivity and relevance), incorporating leadership perspectives to align RM practices with organisational goals & policy frameworks, and the policymakers to ensure policy synergies and effective implementation. By learning from past challenges and leveraging the expertise of diverse stakeholders, the RM Framework project aims to avoid previous pitfalls and achieve sustainable impact. With a strong consortium and a 24-month timeline, the project is poised to deliver tangible results in the rapidly evolving landscape of research assessment, open science, and AI integration. Moreover, by developing a quality label and fostering collaboration with existing networks, the project seeks to ensure long-term relevance and sustainability beyond its duration. Ultimately, the RM Framework project represents a critical step towards enhancing the effectiveness, efficiency, and impact of research management practices across Europe and beyond.

Keywords: era action 17,research management,policy alignment,interoperability,european research area,professionalization,professional recognition,pilot testing,system approach
Fostering Opportunities Towards Slovak Excellence in Advanced Control for Smart Industries (FrontSeat)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Slovakia,Germany,Italy
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1356937.5
EU funding (EUR): 1356937.5
Participants: 3
Project status: SIGNED

The project aims at increasing the research and academic prospects of Slovak University of Technology in Bratislava, Slovakia (STUBA) and at initiating the evolution of STUBA into a modern, reputed excellent institution that performs high-quality research in advanced automatic control, educates top-quality scholars and industrial practitioners, and is successful in active dissemination and exploitation of its research and innovation efforts. For this purpose, STUBA teams up with two renowned research groups in automatic control from RU Bochum, Germany (RUB) and Pisa University, Italy (UNIPI). The specific goals of the action are to reinforce the collaboration with the two research groups from Western Europe, to intensify research in advanced automatic control, to open up new collaboration channels through academic and industrial networking, to train excellent young/senior researchers and project managers, and to effectively disseminate and exploit the research results of STUBA. The unique features of the project are: - Adoption/amendment of internal research project-related rules and procedures and develop project management toolbox, - Research efforts aiming at the continued creation of high-quality research results and software tools, - Establishment of a series of guest scientific and academic lectures, - Exchanges and training of project managers and research (junior and senior) personnel, - Organisation of conferences and invited sessions, seminars with industry, and annual summer schools, - Preparation and implementation of a new PhD curriculum at STUBA, - Establishment of an academic-industrial research and innovation cluster.

Keywords: automatic control advanced control and estimation process industries
Biological production of novel organofluorines via terpene biosynthesis and S.cerevisiae engineering (Bio-fluorine)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Fluorine offers unique properties that are invaluable in molecular design and discovery. Its importance is evidenced by the overrepresentation of fluorine among synthetic small molecule therapeutics. However, unlike synthetic chemists, nature rarely uses fluorine as part of its design tools to construct bioactive molecules. To introduce fluorine into complex scaffolds such as natural products would offer enormous potential for accessing new structural space that combine beneficial features of biological and synthetic molecules for the discovery of novel functions. This proposal, Bio-fluorine, aims to explore the incorporation of fluorine into terpenoids, which constitute the largest and most diverse class of natural products, using biosynthetic enzymes. The proposed research seeks to develop an entirely enzymatic pathway to incorporate fluorine from a simple precursor into diverse carbon skeletons. The proposed work also aims to develop a Saccharomyces cerevisiae chassis for scalable biological fluorine incorporation and novel organofluorine production.

Keywords: biosynthesis,fluorine chemistry,synthetic biology,metabolic engineering
Serving the revolution: educational networks in communist Albania (Expertise)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

My research explores the educational networks of Albania during the Cold War. Using several archives from Albania, China, Italy, and East Germany, as well as conducting interviews, the research investigates in what ways educational exchanges impacted Albania’s economic policies and the formation of an adequate specialised workforce from 1955 to 1978 when hundreds of students were sent abroad to pursue university studies. Albania’s communist past has been little studied. This project proposal contends that studying educational networks and expertise circulation would provide a complete understanding of the communist regime of Albania during the 1960The overall research objective of this proposal is to understand the impact of the educational networks and expertise circulation in Albania’s economic policies from 1955 to 1978. The project is expected to have a major impact in the field of East European transnational networks during the Cold War, and Albania’s communist history as it will explore for the first time the importance of access to foreign expertise and technology, as well as the education of specialized workforce in the building of economic and social institutions in Albania. Historical studies may contribute to the European Union’s adopting adequate policies towards the Balkans – an important task in light of recent events in Eastern Europe with the war in Ukraine. In the meanwhile, the new scientific skills in reading and processing political documents as well as learning didactics in the European Union, together with research methodologies acquired through the two-years’ training at the Department of East and Southeast European History (GOSE), Ludwig Maximilien University (LMU), under the supervision of Prof. Mari-Janine Calic, will allow me to foster my academic profile as a regional expert in East and Southeast European studies, thus increasing my chances to continue my career in academia by becoming a research leader in the field of Cold War in Europe.

Keywords: communist albania,cold war,transnational networks
COMpetition between ion insertion and hydrogen evolution reactions in aqueous BATTery systems (COMBATT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

Aqueous batteries (ABs) hold great potential for large-scale energy storage due to their safety and environmental compatibility. However, they face a fundamental challenge as the redox potential for ion insertion overlaps with the limit of the electrochemical stability window of water. This overlap leads to severe H2 evolution reactions (HER) in ABs, reducing cell efficiency and causing side reactions. Despite its importance, the underlying mechanisms of the competition between ion insertion and HER remain poorly understood. This project aims to address this challenge by combining the experienced researcher's expertise in batteries and X-ray techniques with the host institute's expertise in interfacial electrochemistry and electrocatalysis. We will develop a novel analytical platform, named X-Mass, designed to ensure compatibility between operando X-ray absorption spectroscopy and differential electrochemical mass spectrometry. Through the X-Mass, we will track the chemical composition of the active material and H2 gas production under consistent electrochemical conditions, allowing precise quantification of ion insertion (j-inst) and HER (j-HER) current densities. This will enable us to assess how both reactions vary and compete during battery operation. To further understand the factors governing their rates and limiting steps, we will explore the effects of electrolyte and electrode modifications on j-inst and j-HER. Electrolyte properties will be controlled by additional cations (Cs+, Mg2+, Al3+, etc.), insertion ion species (Li+, H+), and salt concentrations. Electrode properties will be modified using different polymorphs of the model materials, TiO2 and WO3. This approach will deepen our understanding of their reactions particularly in relation to the double layer and electrode electronic structures. Our project will provide new insights into the critical but fundamentally unexplored competition between ion insertion and electrocatalytic surface reactions.

Keywords: aqueous battery,ion insertion,hydrogen evolution,competing electrochemical reactions,x ray absorption spectroscopy,electrochemical mass spectrometry
Synaptic dendritic architecture as a determinant for processing emotional information of opposite value in amygdalar-hippocampal subnetworks (SynEMO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

The ability to form emotional memories of aversive or rewarding stimuli is a crucial ability to determine avoidance or approaching behavior. Recent reports identify specific populations of nThe ability to form emotional memories of aversive or rewarding stimuli is a crucial ability to determine avoidance or approaching behavior. Recent reports identify specific populations of neurons within the basal and lateral nucleus of the amygdala (BLA) and their corresponding projections that are selectively activated during the retrieval of memories of positive or negative valence. Interestingly, BLA neurons projecting to the CA1 area of ventral hippocampus (vCA1) are tuned for either positive or negative predicting cues, suggesting the existence of two distinct pathways routing opposite information to vCA1. How emotional values originating from the BLA are differentially processed by downstream vCA1 neurons remains unclear. An appealing possibility is that vCA1 encodes different valence-related information through distinct spiking patterns and temporal structures. Distinct signal processing in the two BLA-vCA1 pathways might be supported by specific non-linear dendritic input integration, a mechanism that can be promoted by input clustering induced by heterosynaptic plasticity. We hypothesized that an organized synaptic distribution within BLA-vCA1 subnetworks exists, and that local heterosynaptic plasticity determines different temporal structures of neuronal output vCA1 in the processing of negative or positive information. We will use a novel viral-based tracing approach combined with an established assembly-labeling strategy to understand the anatomical input-specific structural organization synapses of different valence-related information along vCA1 dendritic arbour. Then, to dissect the functional implication of such synaptic organization, we will employ a combination of single-spine calcium imaging, electrophysiology, behaviour and in vivo endoscopic calcium imaging.

Keywords: dendritic input clustering,heterosynaptic plasticity,inhibitory plasticity,associative learning,ventral hippocampus,amygdala