Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced 4D Printing Technologies in Corneal Regeneration: A Pathway to Restored Vision (KeratOPrinter)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Finland,Netherlands,Germany,Spain,Ireland
Call: Bio-printing of living cells for regenerative medicine (HORIZON-HLTH-2024-TOOL-11, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7999581.25
EU funding (EUR): 7999581.25
Participants: 9
Project status: SIGNED

Corneal blindness is the 3rd leading cause of blindness globally, affecting >11.7mi people. Although the cornea is the most transplanted tissue, only 1-in-70 patients in need receive a cornea due to a severe shortage of donor tissue. 3D bioprinting offers an attractive solution. However, existing technology cannot mimic the complexity of cornea tissue, which is necessary to reproduce its optomechanical & biological functionality. The KeratOPrinter project thus, proposes a highly ambitious approach to develop a 4D bioprinting suite that can deliver a fully functional, biocompatible, full-thickness native-like human cornea. The consortium combines world-class partners to provide: a) An innovative & scalable cell source with high cell viability & native-like functionality in vivo for the different cell types in the cornea; b) Several multi-material bioink formulations which can reproduce the native-environment heterogeneity & extracellular matrix to deliver the optical, mechanical & biological functionality; c) Single-cell bioprinting resolution with µm accuracy & in-process monitoring for clinical-level quality control at viable printing speeds; d) Clinical handling technology for transportation, logistics & surgical implementation, supported by complementary implementation of multiple bioprinting technologies; e) GMP-compliant cell manufacturing and bioprinting technologies supported by in vivo & GLP studies for fast translation to the clinical environment; f) Early regulatory engagement augmented by a thorough regulatory and ethical analysis culminating in a comprehensive regulatory pathway to support future commercialisation and g) A dedicated community of researchers, clinicians, healthcare providers, regulatory and standardisation bodies, patient groups, technology developers, & industry to translate project results into targeted outcomes & long-term impacts. Ultimately, KeratOPrinter aims to enable millions of people to receive vision-saving therapy by 2035.

Keywords: bioprinting,biofabrication,ophthalmology,cornea,induced pluripotent stem cells,bioink,atmp,melt electrowriting
Regaining the liveability of place: emancipatory futures under climate risk (REVIVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: United Kingdom,South Africa,Australia
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1997558.0
EU funding (EUR): 1997558.0
Participants: 3
Project status: SIGNED

This research investigates how individual transformations in response to a changing climate alter perceptions of habitability in at risk places. By evaluating how individuals react to and understand these changes, this work provides concrete entry points for engaging climate-affected and low-income populations in climate change action. Further, by engaging with the idea of transformation, the project rejects narratives that accept the current socio-economic conditions as necessarily extending into the future. Rather, it focuses on the emotional labour and psychological burden of living with climate risk and interrogates how non-material losses (particularly fear, grief and disempowerment) can be leveraged to reduce current and future vulnerability. The project engages Campbell et al’s (2018) concept of bleak optimism – the agency we acquire when we start learning to accept and live with climate change - to advance understanding of individual transformation in the context of climate change and to identify ways to address emotional and psychological barriers to habitability. Drawing on Freirean praxis to understand how people can shift their perspectives, and drawing on Massey’s theories of a progressive sense of place to find entry points for engagement, the project advances a framework to enact bleak optimism. Employing qualitative methodologies, including arts-based practices, community mapping and ethnography, the project takes an international comparative approach, working with low-income and politically marginalised groups in three locations. Cases are identified where government actors are undertaking transformational adaptation in response to floods (Durban, South Africa and Lismore, Australia), and costal erosion (Happisburgh, UK). The project advances adaptation theory by developing the role of place in individual transformation; and shifting narratives around climate-induced place change to present emancipatory, rather than foreclosed, futures.

Keywords: transformational adaptation,praxis,non material loss and damage
Strategic Energy Technology for Industry in Europe (SET-IndEU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Coordination and support actions
Countries involved: Belgium
Call: Support to the activities of technology areas of the SET Plan: Action dedicated to energy efficiency in industry (HORIZON-CL5-2022-D4-02, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 3
Project status: SIGNED

The CSA Strategic Energy Technology for Industry in Europe (SET-IndEU) is responding to the call HORIZON-CL5-2022-D4-02-06, to propose a structured Secretariat for supporting and strengthening the activities and outcomes of the IWG6 on Energy Efficiency in Industry. The consortium will support the IWG6 to advance the monitoring and revision of the Action 6 Implementation Plan (IP) with the aim of reaching technology targets collectively across SET Plan countries making EU industry less energy, resource and emissions intensive and more competitive. For that purpose, the future needs of the process industry, the R&I targets, and the emerging policy priorities will all be taken into consideration by engaging the IWG6 stakeholders in key activities with industrial and research associations and fora, specifically strengthening the relations, dialogue and exchange with the other SET Plan IWGs and the ETIPs.

Keywords: set plan,process industry,energy efficiency,energy intensive,iwg6,secretariat,electrification,
The Long Arms of Authoritarian States (ARM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Norway,Finland,Netherlands,Greece,Estonia,Latvia,Germany,Sweden
Call: Developing a better understanding of information suppression by state authorities as an example of foreign information manipulation and interference (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-01-01
End date: 2027-02-28
Duration (months): 38.0
Total project cost (EUR): 2999613.75
EU funding (EUR): 2999613.25
Participants: 11
Project status: SIGNED

What strategies do authoritarian states deploy to control information beyond their borders? While disinformation efforts as foreign influence has received extensive attention, little has been done to systematically dissect information suppression strategies. By analysing the ways in which Russia, China, Ethiopia and Rwanda suppress information, the ARM project will conceptualise, identify and help address information suppression as foreign information manipulation and intervention (FIMI) by authoritarian states domestically, within Europe, and among diaspora communities residing in Europe. China and Russia are selected as two major powers highly active in managing information as a part of their foreign policy. Ethiopia and Rwanda, though less influential on the global stage, are some of the most engaged African states in transnational repression. Having substantial diaspora populations in Europe, their reach should be analysed and the implications of their information suppression should be understood. By conceptualising information suppression as part of FIMI, the ARM project will broaden the established approach to FIMI, which has traditionally only been focused on disinformation. By delineating the concept of information suppression within the strategic toolbox of authoritarian regimes, we will contribute to the scholarly discussions how autocracies manoeuvre to strengthen their power base. With the identification of the tactics, techniques, and procedures of information suppression, we will make a toolkit, including recommendations on how to combat information suppression operations, taking the risks and vulnerabilities of target groups into consideration. Through the lifespan of the project, we will involve the defender community: key actors within policy and civil society who try to detect, understand, and respond to threats stemming from authoritarian regimes’ suppression of information.

Keywords: information suppression authoritarianism diaspora china russia rwanda ethiopia
Molecular Polaritonics: Controlling photochemistry with quantum optics (SYZEFXIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Cyprus,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 2
Project status: CLOSED

Photobleaching is one of the most fundamental and important photochemical reactions, especially in organic optoelectronic devices. This effect can cause permanent damage on the device and limit its performance. It has been recently shown that strongly coupled organic microcavities can be used to alter the excited-state reactivity of molecular materials, and more specifically suppress the photobleaching process. In this research project we aim to investigate the suppression of photobleaching in organic strongly coupled microcavities. We will fabricate and characterize a series of different microcavity structures and benchmark the photobleaching process. Strongly coupled dielectric slab microcavities, containing a number of organic fluorescent materials will be fabricated on top of an inorganic blue light-emitting diode (LED). When the LED is electrically driven, blue electroluminescence will optically excite the strongly coupled organic materials in the slab creating white light emission. Such heterostructures will demonstrate enhanced operational stability due to a change in excited-state reactivity by strong coupling.

Keywords: molecular polaritonics,organic semiconductors,microcavities,polariton chemistry,polariton devices
Geomagnetic Excursions and Reversals: Establishing their Atmospheric and Climatic Effects (GERACLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Finland,Austria
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-09-01
End date: 2031-08-31
Duration (months): 72.0
Total project cost (EUR): 9997634.0
EU funding (EUR): 9997634.0
Participants: 4
Project status: SIGNED

The intensity of Earth’s magnetic field, which forms an important shield for our habitat, drops dramatically during geomagnetic excursions and reversals (termed GERs). The Laschamps excursion (~41 000 years ago) occurred during profound climatic changes, possibly leading to drastic effects on the biosphere. While impacts of GERs on the atmosphere can be expected, the magnitude, time scales, and even the direction/sign of effects on our habitat are unknown. The significantly weakened magnetic field shrinks the magnetosphere, enhancing energetic particle fluxes from outer space to the middle and lower atmosphere and even ground. The impact of GERs on the energetic particle precipitation from the magnetosphere is also unknown. The dynamics of near-Earth space and the atmosphere during GERs and their potential impacts have not yet been addressed in full complexity, due to a lack of reliable data, precise models and interdisciplinary approaches. We will unravel key dynamics and connect physical processes during GERs and establish their environmental consequences by synergistically bringing together expertise from palaeomagnetism, magnetospheric, solar, heliospheric, atmospheric physics and climate. We will combine new data-based geomagnetic field models with state-of-the-art magnetospheric, atmospheric, and global Earth-system models for a complete process view. Expected breakthroughs will include new knowledge on the very existence and structure of the magnetosphere and radiation belts, radiation fields and ionization patterns in the atmosphere, and induced physical, chemical and dynamical effects and climate responses during GERs. Further emphasis will be put on potential hazards for our technological society during a potential future GER. GERACLE will go far beyond the current state–of–the–art, provide ground-breaking advances, and form a new paradigm of the consequences of past and yet unexplored GER events for our habitat and the impacts of possible future GERs.

Keywords: solar terrestrial relations magnetospheric physics
Implementing TUSGEAP (TUSGEAP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: EU prize
Destination: EU Award for Gender Equality Champions
Action type: Recognition Prize
Countries involved: Ireland
Call: Newcomer Gender Equality Champions (HORIZON-WIDERA-2023-GENDER-Prize, 2023)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: SIGNED

Technological University of the Shannon: Midlands Midwest (TUS) is one of eleven state universities in Ireland, designated a Technological University on October 1st, 2021. Developing a TUS Gender Equality Action plan (TUS GEAP) was a key priority for TUS upon formation, and we achieved an Athena Swan Legacy Bronze Award in May 2022. This submission provides detail and evidence of progress on this action plan, within the 5 core recommended themes. Our action plan includes 7 goals and 104 actions, with a focus on gender balance in leadership and decision making (TUS GEAP Goal 1, 2 and 3 ), gender equality in recruitment and career progression (TUS GEAP Goal 2 and 3), integration of an intersectional gender dimension into research and teaching content (TUS GEAP Goal 5 and 6) , and measures to address gender based violence including sexual harassment (TUS GEAP Goal 1, 2 and 7). As a newcomer, we have built a strong foundation to further progress our work on gender equality.

Keywords: newcomer foundational geap
Interpretable Artificial Intelligence across Scales for Next-Generation Cancer Prognostics (AIS-CaP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 1494810.0
EU funding (EUR): 1494810.0
Participants: 1
Project status: SIGNED

Computation pathology has the potential to revolutionize cancer care and research, specifically through improving assessment of patient prognosis and treatment selection by applying advanced machine learning methods to digitized tissue sections, i.e. whole-slide images (WSIs). This will allow us to replace the current state-of-the-art of human-developed cancer grading systems. However, the field is currently hindered by significant knowledge gaps: we do not know how to effectively leverage both global and local information in WSIs, how to identify pan-cancer prognostic features, and how to make machine learning models explainable and interpretable. In this project, I will address these key knowledge gaps by building on the novel stochastic streaming gradient descent developed in my group. Specifically, I will integrate innovative multi-task and cross-task learning algorithms with SSGD. Furthermore, I will leverage the latest advances in self-supervision, self-attention and natural language processing to endow deep neural networks with unprecedented transparency and explainability. Last, the project will validate our developed methodology in the largest dataset of oncological WSIs in the world, and, for the first time, identify links between morphological prognostic features and genetic features. By publicly releasing all developed tools and data, the proposed project will have a scientific multiplier effect for the fields of oncology, computational pathology and machine learning. Specifically, the derived cancer-specific and pan-cancer biomarkers can be leveraged in clinical care and cancer research, the enhanced SSGD method for other tasks in computational pathology and our novel multi-task and explainability algorithms can impact other research areas in machine learning, such as remote sensing and self-driving cars.

Keywords: computation pathology,digital pathology,machine learning
Novel antibiotics from Antarctic microbes (NAfrAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Microbial resistance to antimicrobial compounds has become one of the biggest threats to global health. The inability to treat infectious diseases poses a severe threat to human health, and the costs associated with antimicrobial resistance (AMR) are immense. The severity of AMR is emphasized by implementing the fight against AMR into major goals of the United Nations, European Union, or World Health Organization. One of the major issues with AMR is the long-term decline in the development of novel antibiotics; thus, new antibiotics are urgently needed. Microbes living in the harsh condition of Antarctica represent a promising new source that is worth exploring for new antibiotics. Recent studies showed a significant genetic divergence of Antarctic microbes from other microbes worldwide and suggested the enormous potential of these microbes to produce novel bioactive metabolites. Therefore, the main goals of this project are devoted to the characterization of the overall biosynthetic potential hidden within different Antarctic microbial communities through identification of a broad spectrum of the biosynthetic gene cluster (BGC), determination of their diversity, phylogeny, and environmental distribution, followed by target genome mining for the discovery of BGC producing new antibiotics. The acquired knowledge will then be used for the heterologous expression of antibiotic BGC in a suitable host, followed by compounds isolation, bioactivity verification, and the elucidation of the structure. To pursue the raised objectives, interdisciplinary methods will be integrated, such as bioinformatics, molecular/synthetic biology, and analytical chemistry. Such an interdisciplinary project will provide the applicant with excellent training in both scientific and transferable skills. Together with the applicants' participation in the excellent national and international network of the supervisor, Prof. Ziemert, will significantly enhance the applicant's career perspectives.

Keywords: meta genome mining,antarctica,microbes,specialized metabolites,antibiotics
Supporting the smes sUstainaibility and REsilience transition towards industry 5.0 in the mobility, transport & automotive, aerospace and electronics European ecosystems (SURE 5.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Coordination and support actions
Countries involved: France,Spain,Austria,Germany,Ireland,Italy,Estonia,Greece
Call: 'Innovate to transform' support for SME's sustainability transition (CSA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2025-06-30
Duration (months): 37.0
Total project cost (EUR): 4988125.0
EU funding (EUR): 4988125.0
Participants: 11
Project status: SIGNED

The economic crisis caused by the COVID-19 pandemic and several successive periods of lockdown demonstrated the fragility of traditional economic sectors, particularly in manufacturing. At the same time, the crisis provided a springboard for the most advanced technology companies, mostly based in the US and China, to open up new markets. The objective of the SURE 5.0 project is to support European SMEs seeking to take advantage of the opportunities brought by the 4th industrial revolution, namely: the digitalisation of production processes and the use of advanced technologies, while fostering the key principles of Industry 5.0: human centricity, sustainability and resilience. SURE 5.0 covers three strategic ecosystems for the European Union: (i) Mobility, Transport & Automation (ii) Aerospace & Defence, and (iii) Electronics. The project will enable SMEs in these three ecosystems to receive assessments, recommendations, training, tailored services and financial support to implement Industry 5.0 principles that will ultimately provide them a competitive edge. Selected SMEs will be invited to join the SURE 5.0 Community of Practice Alliance. Led by the members of the consortium, this Community will promote peer-learning exchanges between members and with external organisations leaders. The consortium is composed of 5 clusters (AV, CEAGA, SAC, ANFIA, CORALLIA) representing more than 1000 SMEs, 3 RTOs (FhG, AIMEN, TALTECH) with an outstanding expertise in supporting companies on technological issues, INIZIATIVA a consulting company specialised in the elaboration of innovative and sustainable business models, F6S a company expert in EU cascade funding projects, and EITM (West) the European Innovation Community in the field of manufacturing. In terms of expected project results and his impact, 1,000 SMEs will be involved in the project activities, 700 will be assessed, 90 will be supported with services from the partners and 53 will receive financial support.

Keywords: aerospace,automotive,electronics,industry 4 0,industry 5 0,sme,sustainability,resilience