Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of Epithelium Apical Polarity: Does the mechanical cell-cell adhesions play a role? (DEAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

One fundamental question in biology is how are epithelial tubes polarised from initially unpolarised cells to establish coherent tissues. In this project, I will determine the role of cell-cell adhesion mediated force during de novo polarisation of epithelial tubes. I will use two models for the studies of this project. First, I will use a mouse embryo stem cell (mESC) culture model that phenocopies the morphogenesis of the very early mammalian embryo during implantation, when the epiblast forms a centrally located, polarised lumen. This minimal model will allow me to control cell number and cell-cell interaction so that I can analyse the initiation of absolutely naïve junctional adhesions in relation to polarisation. Second, I will use the zebrafish neural tube as an in vivo model of epithelial tube formation. I will use a cutting-edge optogenetic approach to both image and manipulate the process of apicobasal polarisation and junctional formation at the single cell level within a whole vertebrate organ. This will also allow me to compare whether the principles driving polarisation are conserved across different systems. I will carry out this research project under the supervision of Clare Buckley at University of Cambridge. During this project, I will have a perfect chance to apply my knowledge in epithelium cell biology into the studies of vertebrate development, and benefit from expertise across disciplines to establish my network and research filed for my future career. The studies of this project will extend our understanding of the biological importance of cell adhesions and advance our knowledge of the fundamental principles of tissue patterning during development. A better understanding of polarisation during development may help us to understand dysregulation of cell polarity in diseases.

Keywords: epithelium,cell polarity,lumenogenesis,e cadherin,mechanobiology,optogenetics,mouse embryo stem cell,zebrafish embryos,neuroepithelium,cell cell contacts,cytoskeleton
Cri/oFlex: The missing link towards large scale quantum computing (CrioFlex)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-03-01
End date: 2022-10-31
Duration (months): 32.0
Total project cost (EUR): 2804016.25
EU funding (EUR): 1957036.0
Participants: 1
Project status: CLOSED

Today, an emergent quantum industry is eager to implement quantum computers that are significantly larger in size then current prototypes. The bleeding edge are now quantum processors having about 50 quantum bits, and the challenge is to pass the 1,000 quantum bit milestone. But this also means a huge amount of communication-channels between those quantum processors in a cryogenic fridge with external control electronics outside these fridges. At present, existing (coax) cabling technologies are inadequate for connecting quantum processors of that size with the outside world. This poses a critical bottleneck for developing large scale quantum computers, and without solving that problem, the quantum revolution will come to a halt. Delft Circuits is the first company that has developed ultra-thin cabling solutions for the emergent quantum industry. These are high-tech, flexible cables, fully dedicated to microwave frequencies in cryogenic environments. We are selling pre-cursor cabling products to various organisations worldwide since Q1 2019. Our Cri/oFlex® technology allows our customers to build quantum computers requiring many communication channels, since our present technology is already capable of shrinking the footprint significantly. Such reduction in footprint is an essential requirement for paving the way to large scale quantum computing. We will develop in this project a solution for integrating microwave and thermal components in a monolithic cabling solution. This is an essential step to further increase the scale of quantum computers towards 1,000 or more quantum bits. We have setup a network of validation and qualification partners, which collaborate in the project. Thereby, this project enables us to accelerate our product development to TRL8 significantly, to strengthen the European eco-system of SMEs in quantum industry, and to become an important player in the emergent value chain.

Keywords: quantum computing,cryogenic interconnection,microwaves,thermodynamics,quantum industry
Graphene-based revolutions in ICT and beyond (GRAPHENE FPA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Tackling grand interdisciplinary science and technology challenges
Action type: Framework Partnership Agreement
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Spain,Estonia,Ireland,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Israel,Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Ireland,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Germany,Spain,Spain,Spain,Italy,Austria,Germany,Spain,Italy,Italy,Italy,Switzerland,Switzerland,Switzerland,Switzerland,Switzerland,Türkiye,Belgium,Belgium,Belgium,Finland,Finland,Greece,Greece,Greece,Poland,Sweden,Sweden,Sweden,Belarus,Switzerland,Switzerland,Belgium,Sweden,Sweden,Belgium,Bulgaria,Hungary,Norway,Sweden,France,France,France,France,France,France,France,France,France,France,France,France,France,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: 2014: Framework Partnership Agreement (H2020-FETFLAG-2014, 2014)
Start date: 2015-03-30
End date: 2020-12-29
Duration (months): 69.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 267
Project status: SIGNED

The proposed Framework Partnership Agreement aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries – from flexible, wearable and transparent electronics, to high performance computing and spintronics. A large European consortium of world-leading academics and key industries, is cooperating closely to create a new disruptive technology. The scope and level of ambition of this endeavor is such that it can only be realized through a large scale coordinated effort that integrates the entire value chain from materials to components and systems. The rewards of the Graphene Flagship will impact the lives of Europeans with increased standard of living through new products, job opportunities, and economic growth. In the ten-year time frame, disruptive technologies based on graphene and other two-dimensional materials extend to new areas such as biomedical applications, with the aim of becoming new platform materials, as ubiquitous as steel or plastics. This progression from scientific excellence to industrial exploitation and societal impacts is the guiding principle of the Graphene Flagship.

Keywords: graphene
How did our ancestors use their feet? Evidence of bipedalism and climbing from internal bone structure. (FOOTSTEP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-10
End date: 2024-01-09
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

During the course of human evolution, we have transitioned from the arboreal environment of our ancestors to become committed, terrestrial bipeds. These changes are reflected in many aspects of our postcranial skeleton, including our highly specialised foot. Due to the mosaic morphology of fossil hominins, it is remains unknown in what ways their locomotion differed from our own, both in a continued dependence on arboreal environments and in the way they walked bipedally. As internal bone structure, both cortical and trabecular bone, remodel during an individual’s lifetime in response to their behaviour it has the potential to reveal how they actually behaved. FOOTSTEP will answer these questions by using state-of-the-art, whole-bone methods to analyse the internal bone structure of the foot (all tarsals and metatarsals) of extant non-human great apes and humans from a range of populations. These methods will include a cutting-edge geometric morphometric approach. FOOTSTEP will analyse internal bone structure of all tarsals and metatarsals of Australopithecus africanus, Paranthropus robustus, Australopithecus sediba, Homo naledi, Homo floresiensis and the OH8 foot (Homo habilis/Paranthropus). The project will change our understanding of locomotor evolution in the human lineage, and through including a range of taxa, will resolve questions about locomotor variability among hominins. Results of the project will be disseminated to a broad range of target audiences, via high-impact, open access journal publications, at scientific conferences across three continents and to non-specialists through public outreach activities. The training that I will receive during the fellowship, along with the opportunities available at the University of Kent to further develop my transferable skills, will provide me with the knowledge and experience required to enhance my future career prospects.

Keywords: trabecular,cortical,cancellous,functional morphology,locomotion
Phononic Quantum Sensors (PHOQS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1976164.0
EU funding (EUR): 1976164.0
Participants: 1
Project status: SIGNED

In this project, we will develop mechanical systems of unprecedented coherence under full optomechanical quantum control. At the same time, these systems provide a versatile and practical platform for force measurements and sensing. This novel and unique combination generates a host of opportunities in science and technology, ranging from fundamental tests of quantum decoherence and highly non-classical mechanical sensor states, to new kinds of mechanical quantum transducers. These advances will be enabled by recent pioneering work of my group in the area of phononic engineering, that is, tailoring the phononic density of states in periodic geometries. In combination with state-of-the-art cryogenic refrigeration, we will achieve coherence times of mechanical quantum states at the level of one second, challenging existing models for mechanical state collapse. We will implement cavity-optomechanical interfaces to these systems which operate deeply in the quantum regime, and by themselves find applications as narrow, noiseless filters sought-after for gravity wave detectors. Furthermore, we will harness purely mechanical parametric interactions as a new resource. This allows noiseless gain immediately in the sensing device, and the preparation of highly nonclassical sensor states, such as strongly squeezed and entangled states. To demonstrate the sensing capabilities of this platform, we will functionalize it magnetically, and perform real-time measurements of single electron spins. We will resolve the split of the mechanical wavefunction as it interacts with a spin in a superposition state, and eventually prepare mechanical Schrödinger cat states, never generated before with a massive, millimetre-sized object visible to the naked eye. At a practical level, this project catalyses the experimental convergence of spin sensing and quantum optomechanics, with synergistic effects both for magnetic resonance imaging at the molecular scale and spin-based quantum networks.

Keywords: quantum optomechanics,phononic engineering,force sensing
REciprocal LOcal ADapatation: the genetic, behavioural and chemical study of the evolutionary maintenance of a mutualism (RELOAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-06-30
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: CLOSED

The goal of this research is to identify and characterize genetic, behavioural and biochemical mechanisms underlying reciprocal local adaptation between partners in a complex mutualism. It will focus on a unique and outstanding model system found in the New World tropics: the “devil’s gardens” created by the ant, Myrmelachista schumanni, whose workers systematically attack and kill seedlings of foreign plants that germinate too close to their host plants. This cultivation behaviour results in low diversity, orchard-like stands of their host plants in the middle of some of the most diverse rainforests on earth. This project will bring together researchers from Harvard University and the Max Planck Institute to address three main questions through a combination of newly developed genome sequencing techniques, large-scale field-ecology behavioural experiments and state-of-the-art chemical analyses: (1) Do Myrmelachista schumanni and its host plants reciprocally influence each other’s population sizes, level of gene flow and genetic structure? (2) How specialized are interactions between Myrmelachista schumanni and the several species of plants that it cultivates? (3) What are some of the proximate mechanisms underlying host specificity, and in particular, can ants recognize different plant species and if so, how? In carrying out this research, postdoctoral fellow Pierre-Jean Malé will expand his expertise by gaining training in phylogenomics and chemical ecology. The project, referred to here as "RELOAD" (forREciprocal LOcal ADaptations), will also enable him to broaden the ecological and evolutionary scale of his research, and enhance his long-term goal of obtaining a faculty position at a European university and/or research institution.

Keywords: mutualism,biological adaptation,chemical ecology,biological chemistry
SME-led Space Portal for Europe (HATCH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Coordination and support actions
Countries involved: Spain,Poland,Latvia,United Kingdom,Portugal
Call: Space portal (H2020-COMPET-2017, 2017)
Start date: 2017-11-01
End date: 2019-06-30
Duration (months): 20.0
Total project cost (EUR): 512891.25
EU funding (EUR): 512891.25
Participants: 5
Project status: CLOSED

The project consortium for HATCH comprises 4 SMEs and 1 high-profile technology centre. The aim of HATCH is to develop a scalable, contemporary, interactive and user-driven platform for promoting European space projects and related activities to professionals and citizens. It aims to overcome obstacles enabling researchers, innovators and other stakeholders to focus on achieving their objectives. This proposal answers the call requirements through 6 objectives, split into 8 Work Packages. HATCH will use modern solutions: comprehensive data analysis, proven methods and high standards for development and validation. The HATCH consortium has completed a preparatory study to identify groups of "User Persona" through sample surveys, interviews and secondary data analysis. As a result, the consortium has gained insight into stakeholders’ goals, needs and behaviour patterns to underpin the user-driven solution. The Portal’s visual layout will appeal to a wide range of users to showcase European research, encourage collaboration, form partnerships, analyse funding, commercialise results and generate interest in space exploration and science for all. Elastic search and bundle retrieval are some of the techniques to be used by an experienced team to deliver the best search functionality. Individuals will be able to create their own filters and save results to create research networks. Search engine optimisation tactics and an extensive communication/dissemination strategy will give visibility and awareness to all stakeholders making a strong base for the future. Consortium members are focused on maximising the impact of the project. 2 partners manage space-related online resources (on a smaller, regional/national scale). Another partner understands user requirements and the translation into solid activities within a webpage. 1 partner provides expertise on features such as user experience or data mining. 2 partners have experience in conducting projects in the space sector.

Keywords: portal,europe,project results,h2020,awareness,citizens,professionals,scientists,space sector,space industry,gnss,copernicus,galileo,research,technology,impact,communications
SMART MONITORING SYSTEM BASED ON A REAL-TIME TRACKING OF OVERHEAD TRANSMISSION LINE STATE (SMS-OHTL)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2016-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objective of this Phase I is to perform a thorough feasibility study to verify the practical and economic viability of an innovative and inexpensive system for reliable real time monitorisation of the ampacity (the instantaneous current carrying capacity of an overhead power transmission line) in the high-voltage European Transmission System Operators market. Based on the propagation time of ultrasonic frequency acoustic waves, the system determines the length of the cable, which consequently provides the average temperature of the conductor and permits the dynamic calculation of the average transmission capacity of overhead lines in real-time, thus allowing a potential increase of 20-25% of the load capacity (in average) with respect to static seasonal ratings and an overall improvement of the management of the transmission and distribution network. RELOGABLE will define in this Phase I its marketing and communication strategies. The actual market chances will be analysed and a more detailed business plan will be developed in order to have the technology ready for commercialisation with appropriate licensing and other business arrangements concluded. The work carried out in Phase I will allow RELOGABLE to objectively and rationally uncover the strengths and weaknesses of the SMS-OHTL project, including potential design modifications to adapt the system to an industrial environment and the study of scalability and implementation of the industrial production process, identifying the existing opportunities present in the environment and establishing the proper measures to mitigate the effect of potential threats and barriers. These studies will allow RELOGABLE to diversify its business and access a new market with high innovation potential reaching a turnover of €10 million by 2021 and create at least 70 direct jobs in that period.

Keywords: overhead transmission line,monitoring system,energy efficiency,power transmission line,transport,capacity,loadibility,length of spans,ampacity,european transmission system operators market
Nuclear Theory from First Principles (NuclearTheory)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 2499206.0
EU funding (EUR): 2499206.0
Participants: 1
Project status: SIGNED

Nuclear physics aims at understanding the emergence and properties of complex structures like atomic nuclei from QCD, the underlying theory of the strong interaction, and addresses some of the Big Science Questions including the origin of the elements, the limits of nuclear stability, searches for physics beyond the Standard Model and physics of neutron stars. Answering these questions requires a reliable theoretical approach to nuclear structure and reactions. Chiral effective field theory (EFT) combined with ab initio many-body methods provides an efficient and well-founded framework, and a major effort is needed to push the precision of nuclear forces and develop an efficient matching with the emerging lattice QCD results. Recently, the PI and his group made significant breakthroughs in the two-nucleon (2N) sector by developing chiral EFT interactions which are more precise than any other potentials and, for the first time, qualify to be regarded as partial wave analysis (PWA). This shows that chiral EFT can, without any compromises on rigor and consistency, be advanced to a precision tool. While the 2N sector can be considered as solved, three-nucleon (3N) scattering data could so far not be described showing that the simplest nuclear system beyond the 2N one is not understood. Given this success in the 2N sector, I propose to perform for the first time a PWA of 3N scattering and to determine the Hamiltonian complete up through fifth order. The project aims at solving the long-standing 3N force challenge and development of accurate, state-of-the-art nuclear forces determined solely by the chiral symmetry of QCD and few-nucleon data. The resulting Hamiltonian will be used in large-scale ab initio calculations of nuclear structure and reactions. We will also develop an efficient interface between lattice QCD and chiral EFT. If successful, these studies will establish a rigorous, fully microscopic approach to nuclear physics firmly rooted in QCD.

Keywords: chiral perturbation theory,nuclear forces,three body force,few body physics,effective field theory