Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Low-energy leak-proof double seat control valve based on a water hydraulic actuator system (HYDRACTVAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Denmark
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 1063750.0
EU funding (EUR): 744625.0
Participants: 1
Project status: CLOSED

The HYDRACTVAL project aims to design, test and demonstrate a leak-proof double seat control valve for the brewery and dairy industries. It will be based on and fully exploits the benefits of its core technology – a patented water-based hydraulic actuator with regulation functionality. The novel technology holds a range of clear advantages over compressed air:  Energy efficiency and reduced CO2 emission: Reducing electricity consumption and carbon emissions by more than 65%;  Precision: Accurate positioning of valve position allowing any valve to be used for regulation besides fully open/close position.  Hygiene: Leak free and sterile hydraulic system prevents spread of air borne bacteria, oil, etc., reducing the risks of food and beverage contamination.  Reliability: Reducing waste by avoiding unintended opening of valves and leaks. Avoids cavitation.  Cost: Reduces the number of valves needed for a given process, reduces the cost of production and installation of valves, and allows smaller and more flexible plants. The water-based hydraulic actuator system promises to offer a new level of control over valves. To exploit this control to its maximum potential – and thus pave the way for broad market impact - a new process valve would have to be designed, adapted and demonstrated. The technology will have the potential to be adapted for other markets currently using pneumatic valves. It will significantly increase KM’s competitiveness through launching a game changing product in a conservative industry, and opening vast and global market opportunities. HYDRACTVAL will drastically decrease the energy consumption in food and beverage industries, with consequent decrease in greenhouse gas emissions and carbon footprint. It will also have a positive impact on the food security by reducing the risks of contamination. This is coherent with the challenge under the work programme topic Resource-efficient eco-innovative food production and processing (SFS-08-2014).

Keywords: actuators,breweries,dairies,food safety,hydraulics,regulation,valves
The unknown force: How gossip shapes the functioning and performance of organizational groups. (FORCE-OF-GOSSIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 1999693.0
EU funding (EUR): 1999693.0
Participants: 1
Project status: SIGNED

Aim: To radically change the field of gossip research, this project builds theory that connects divergent perspectives on the effects of gossip on work group outcomes. Background: Gossip, informal evaluative talk about absent third parties, is omnipresent in organizational groups. However, for scientists and practitioners alike, it is still an "unknown force" in organizations, because research findings about its effects on group functioning and performance are inconsistent. Whereas some studies point to the disruptive aspects of gossip, others claim it enhances group cooperation. Innovation: I present the Gossip Origins, Subsequent Social Information Processing, and Performance (GOSSIPP)-framework, a new paradigm that views gossip in groups as a multi-level phenomenon: It, for the first time, systematically connects individual gossipers' intentions to group-level outcomes via social information processing by gossip recipients. Propositions: Group members may gossip to benefit themselves or their group (proself vs. prosocial intentions, or motives). Receivers' reactions to gossip are affected by how they perceive senders' motives. These reactions in turn affect group-level processes. How these processes affect group performance depends on the type of group task. Methodology: Four subprojects test the framework, applying a cross-disciplinary multi-method approach. Subprojects 1 and 2 employ laboratory experiments to assess causal effects of gossipers' motives and recipients' reactions on group processes and performance. Subproject 3 examines effects of different group compositions and feedback loops between performance and gossip, employing self-organizing computer modelling. Finally, to assess external validity, Subproject 4 examines work teams. Results will lead to long-sought understanding of when and why gossip is a functional or dysfunctional force and will enable evidence-based advice to organizations about the meaning and functionality of gossip for groups.

Keywords: informal information exchange in organizations,gossip,prosocial motivation,proself motivation,attributions,group performance,cooperation,divergent and convergent group processes
COMPACT: FROM RESEARCH TO POLICY THROUGH RAISING AWARENESS OF THE STATE OF THE ART ON SOCIAL MEDIA AND CONVERGENCE (COMPACT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Ukraine,Ireland,Belgium,Bulgaria,Greece,Croatia,Slovakia,Slovenia,Latvia,Portugal,Denmark,United Kingdom
Call: Media and content convergence (H2020-ICT-2016-2, 2016)
Start date: 2017-10-01
End date: 2020-12-31
Duration (months): 39.0
Total project cost (EUR): 999562.5
EU funding (EUR): 999562.5
Participants: 16
Project status: CLOSED

The objective of the project is to increase awareness of the latest technological discoveries among key stakeholders in the context of social media and convergence. The dissemination will be based on key areas that impact the convergence of social media. This includes scientific, political, cultural, legal, economic and technical areas, to name but a few. This is particularly essential to provide knowledge support, but also stimulate an appropriate debate among the various stakeholders (the public, the researchers, scientific and other policy makers and regulators) on the desirable future policies and frameworks that are required and lacking in the state of the art concerning media and content convergence. Additionally, the project seeks to provide research on and experience-exchange of policy and regulation strategies. The aim is to support the R&D digital programs by spreading the innovative ideas and also the innovated outcomes in convergence. To achieve this, the project will offer analyses and road maps of related initiatives. In addition, extensive research on policies and regulatory frameworks in media and content will be developed, integrating crucial topics such as: the types of regulation that are possible, sensible, and currently implemented, joined with contextual analysis of the corresponding issues; court case study on the types of cases that are brought before domestic courts and their implications on fundamental rights, the ways in which domestic courts review interference with fundamental rights in the pursuit of public interests, and the impact of court decisions on national laws and policies concerning social media and convergence; and future trends and recommendations in the policies and regulatory frameworks in media and content convergence. All of the EU countries will be included, although the involvement of additional countries is not excluded.

Keywords: social media,convergence,policy,legal framework
Personalized And/Or Generalized Integrated Biomaterial Risk Assessment (PANBioRA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Ireland,Albania,Spain,Germany,Germany,Estonia,Finland,Belgium,Serbia,Belgium,France,France,Czechia,United Kingdom
Call: Development of a reliable methodology for better risk management of engineered biomaterials in Advanced Therapy Medicinal Products and/or Medical Devices (H2020-NMBP-2017-two-stage, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 7992471.0
EU funding (EUR): 7992471.0
Participants: 20
Project status: CLOSED

PANBioRA aims at providing a comprehensive solution for the time- and cost-effective risk assessment of i) new biomaterials under health or disease states or ii) a given biomaterial for each patient in a personalized manner. It will standardize the evaluation of biomaterials and open the venue for pre-implantation, personalized diagnostics for biomaterial based applications. PANBioRA will provide a modular platform to assess risks at different aspects and length scales. This comprises antibody response, cytotoxicity/genotoxicity at cell level, systemic and local effects at tissue and connected tissues (organ-on-a-chip) level. Moreover, physicochemical and biomechanical characterisation as well as predictive modelling at systems level will complement the system. This will be achieved by connecting testing modules in a structure supported by web-based modelling and risk radar tools together with a biomechanical testing system. The platform will incorporate standardized protocols yielding significantly more information than the current methods for biomaterial risk assessment. Its accuracy will be demonstrated using known reference materials and validated in a pre-clinical setting. PANBioRA will for the first time, predict the patient specific response to a given biomaterial before its implantation. This measure will allow for the selection of the best suitable material, minimizing side effects and improving health outcomes. It will also accelerate the process of validation of the biocompatibility of new devices by providing an automated, comprehensive process for the parallel assessment of risks at different scales aiding new biomaterial discovery and commercialisation. Altogether, PANBioRA will lead to a substantial economic impact due to a reduction of the amount of tests, decrease in healthcare costs due to complications. It will provide the necessary tools proper risk management related to biomaterials.

Keywords: personalised risk assessment,immune response,microfluidics,real time monitoring,standardization,cytotoxicity,genotoxicity,microbiota,biomaterial tissue interactions,modeling
Ocean deoxygenation effects on threatened top predators: New understanding and predictions from novel bio-logging instruments and data (OCEAN DEOXYFISH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-10-01
End date: 2026-09-30
Duration (months): 72.0
Total project cost (EUR): 3110111.0
EU funding (EUR): 3110111.0
Participants: 1
Project status: SIGNED

Climate-driven reductions in dissolved oxygen (DO) of the global ocean interior (ocean deoxygenation) is leading to expansion of permanent oxygen minimum zones (OMZ) that comprise about 7% of ocean volume. Impacts on marine animal distributions and abundance may be particularly significant for high-oxygen-demand top predators, such as warm-bodied tunas and sharks, by reducing habitat volumes as OMZs expand (habitat compression) and concentrating fish further in surface waters where they become more vulnerable to fisheries. But predictions of how exploited oceanic fish actually respond to OMZ expansions are not based on mechanistic understandings, principally because direct measurements of oxygen tolerances and associated metabolic costs have not been determined. OCEAN DEOXYFISH will bring about a step change in understanding of OMZ impacts on oceanic ecology by applying our existing expertise in animal movement studies and by developing new biologging technologies and in situ physiology for measuring oxygen tolerances and metabolism directly in free-living fish. This will enable major unknowns to be addressed concerning how oceanic fish respond physiologically and behaviourally to hypoxia, the role of OMZs in upper-trophic-level ecology, how oceanic fish habitats change with predicted OMZ expansion, and whether this will increase fish vulnerability to fishing gear. We will achieve objectives through linked field, experimental and modelling studies. By focusing on key processes underlying fish responses to DO in situ, new modelling approaches will establish effects of future warming and OMZ shoaling on fish niches and determine how these shift distributions and alter capture risk by fisheries. The project represents a discipline-spanning approach linking physiology to ecology and oceanography, with wide-ranging outcomes for understanding global biotic responses to warming and ocean deoxygenation with direct relevance to sustainable fisheries and species conservation.

Keywords: marine fish ecology,movement ecology,fish physiology,shark,tuna,satellite and archival tracking,respirometry,climate change,oxygen minimum zones,hypoxia,oceanography,conservation,fisheries
Investigation of a novel immune cell type in Tuberculosis: characterization of the specificity, function and pathogen killing ability of T cells restricted by non-classical HLA-E molecules (MTBHLAE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Based on recent work from the Tuberculosis Research group in the Department of Infectious Diseases at LUMC on the discovery of highly in vivo expressed Mycobacterium tuberculosis (Mtb) antigens, using genome wide bioinformatics and immunomics approaches, I here propose to identify Mtb derived epitopes presented by HLA-E from the most immunogenic and protective antigens identified thus far during Mtb infection. HLA-E restricted Mtb specific CD8+ T-cells represent a novel human T-cell subset, which has only very recently been identified, and which could be highly relevant during the immune response to Mtb infection. HLA-E expression is enriched in Mtb phagosomes compared to classical HLA class Ia family members, thus facilitating HLA-E loading by Mtb peptides in infected cells (Grotzke et al. 2009). In contrast to most other HLA class I molecules, HLA-E is relatively resistant to down-regulation by HIV, a co-infection that is responsible for most of the TB related mortality [2]. Identification of novel epitopes will be performed in close collaboration with Dr. Thomas Abeel at TU Delft during a 3-month secondment where I will implement an improved prediction algorithm for the selection of the best candidate epitopes. I will subsequently determine the ability of the identified epitopes to induce superior CD8 T cell activation, including their ability to induce Mtb killing in infected human macrophages. I will further dissect the molecular determinants that control Mtb peptide binding to and presentation by the two HLA-E alleles in relation to T cell activation. Furthermore, I will look at specific molecular elements of the T cell receptor (TCR) associated with efficient T cell responses by TCR sequencing. Taken together, I will identify new Mtb HLA-E presented epitopes, dissect their binding to both alleles, determine their superior ability to induce T cells that are capable of Mtb killing and the resulting knowledge will be harnessed for TB vaccine development.

Keywords: hla e,mycobacterium tuberculosis,t cells,vaccine,epitopes
Co-designed Innovation and System for Resilient Exascale Computing in Europe: From Applications to Silicon (EuroEXA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: High Performance Computing
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Belgium,Greece,Greece,Greece,Sweden,Greece,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Co-design of HPC systems and applications (H2020-FETHPC-2016, 2016)
Start date: 2017-09-01
End date: 2021-12-31
Duration (months): 52.0
Total project cost (EUR): 19949022.5
EU funding (EUR): 19949022.5
Participants: 18
Project status: CLOSED

To achieve the demands of extreme scale and the delivery of exascale, we embrace the computing platform as a whole, not just component optimization or fault resilience. EuroEXA brings a holistic foundation from multiple European HPC projects and partners together with the industrial SME focus of MAX for FPGA data-flow; ICE for infrastructure; ALLIN for HPC tooling and ZPT to collapse the memory bottleneck; to co-design a ground-breaking platform capable of scaling peak performance to 400 PFLOP in a peak system power envelope of 30MW; over four times the performance at four times the energy efficiency of today’s HPC platforms. Further, we target a PUE parity rating of 1.0 through use of renewables and immersion-based cooling. We co-design a balanced architecture for both compute- and data-intensive applications using a cost-efficient, modular-integration approach enabled by novel inter-die links and the investigation of a custom EuroEXA processing unit with integration of FPGA for data-flow acceleration. We provide a homogenised software platform offering heterogeneous acceleration with scalable shared memory access and create a unique hybrid geographically-addressed, switching and topology interconnect within the rack while enabling the adoption of low-cost Ethernet switches offering low-Latency and high-switching bandwidth. Working together with a rich mix of key HPC applications from across climate/weather, physics/energy and life-science/bioinformatics domains we will demonstrate the results of the project through the deployment of an integrated and operational peta-flop level prototype hosted at STFC. Supported by run-to-completion platform-wide resilience mechanisms, components will manage local failures, while communicating with higher levels of the stack. Monitored and controlled by advanced runtime capabilities, EuroEXA will demonstrate its co-design solution supporting both existing pre-exascale and project-developed exascale applications.

Keywords: co design,scalability,energy efficiency,performance
Dynamic responsive porous crystals (DYNAPORE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 2493425.0
EU funding (EUR): 2493425.0
Participants: 1
Project status: CLOSED

The project addresses the long-term vision of man-made materials with chemical selectivity and functional efficiency produced by dynamic structural flexibility. These materials are not intended as protein mimics; they are however inspired by nature’s use of flexible rather than rigid systems, with their ability to dynamically restructure around guests and thus perform highly specific chemistry. Such materials would transform chemical processes through their precision, for example by reorganising to accelerate each step of a cascade reaction without reagent or product inhibition. The road to this vision is blocked as we do not have the methodology and understanding to control such materials. The aim is to develop synergic, multidisciplinary experimental and computational capability to harness the dynamics of flexible crystalline porous solids for function, demonstrated in separation and catalysis. This will enable design and synthesis of materials that controllably adopt distinct structures according to their chemical environment to optimise performance. We will create a new workflow that integrates understanding of the structure-composition-dynamics-property relationship into the materials design and discovery process. This workflow builds on proof-of-concept in (i) chemical control of dynamical restructuring in flexible crystalline porous materials and in the use of dynamics to (ii) enhance function and (iii) guide synthesis. Crystalline flexible porous materials are selected because crystallinity maximises the atomic-scale understanding generated, which is transferable to other materials classes, whilst porosity permits sorption and organisation of guests that controls function. This inorganic materials chemistry project develops integrated capability in chemical synthesis (new metal-organic frameworks and linkers), computation (prediction and evaluation of structure and dynamical guest response), characterisation (e.g. by diffraction) and measurement of function.