Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A novel medical device for the treatment of Endometriosis (EndoSolve)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Ireland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2021-01-01
End date: 2021-12-31
Duration (months): 12.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Endometriosis is one of the most prevalent, impactful and undertreated disorders to affect European women. The condition is defined as an estrogen-dependent disorder, where endometrial tissue forms lesions outside the uterus resulting in chronic pain and infertility. Endometriosis affects an estimated 10% of European women in the reproductive-age group (176 million women worldwide and 10.7 million in the EU) with significant impact on their physical, mental, and social well-being (This impact is exacerbated by the fact that the correct diagnosis is made as late as 8–11 years after symptom presentation. Treatment delays are due to a lack of a reliable non-invasive diagnostic test, and the fact that the reference diagnostic standard is laparoscopy (invasive, expensive and not without risks). As there is no permanent cure for endometriosis, current therapies have three main goals: (i) to reduce pain; (ii) to increase the pregnancy rate for women who desire to have children and (iii) to delay recurrence for as long as possible. The EndoSolve project will develop the first medical device to treat the underlying mechanism of endometriosis, providing a long-term non-pharma treatment for the chronic disease.

Keywords: medical devices,endometriosis
Next Generation Power Sources for Self-sustainable Devices – Integrated Multi-source Energy Harvesters (NextGEnergy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 191325.6
EU funding (EUR): 191325.6
Participants: 1
Project status: CLOSED

In recent years, various energy harvesting techniques have been realised to overcome shortcoming of batteries in terms of lifespan, overall cost-effectiveness and chemically safe electronics. Energy harvesters convert different forms of environmental energies into electricity thus making devices self-powered. However, with over a decade’s development, energy harvesters have not been able to overtake batteries yet, although academia and industry are keen to apply it in electronics. One of the reasons is that the power level provided by a single-source energy harvester, which most research has been focused on, is not high or stable enough. Therefore, a crucial and urgent question has been raised – how to release the huge potential of energy harvesting technology? This proposed action is addressing the above scientific/engineering question by exploring multi-source energy harvesting on a single piece of material. Perovskite structured materials are able to exhibit piezoelectric, pyroelectric or photovoltaic effect which has been utilised to harvest kinetic, thermal or solar energy separately. This action will combine these three effects on the same perovskite for the first time ever. Solid-state reaction will be used to synthesise the materials; thick- and thin-films will be deposited through physical methods; the materials and films will be structurally analysed, multi-functionally evaluated and compositionally optimised, to establish new inter principles of kinetic-thermal-solar multi-harvesting. Such a research topic of multi-functional materials and devices is also a ‘‘roadmap’’ of the European Science Foundation. It will conduct an interdisciplinary research across piezoelectricity, pyroelectricity and photovoltaics, and will require contributions from materials science, electronics and chemistry. Positive outcome of this action will lead to a breakthrough in the development of self-sustainable devices, and thus leading to a revolution in smart human societies.

Keywords: micro power energy harvesting,multi source harvesting,piezoelectric,pyroelectric,photovoltaic,perovskite,multi functional,ferroelectric,piezoelectric ceramics,thick film,thin film
Development and testing of the European Innovation Audit tool for Social Innovation (DepoSIt)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Italy,Germany,Romania,Croatia,Netherlands
Call: Supporting experimentation in innovation agencies (H2020-INNOSUP-2018-06-two-stage, 2018)
Start date: 2019-09-01
End date: 2022-02-28
Duration (months): 30.0
Total project cost (EUR): 499611.25
EU funding (EUR): 499611.25
Participants: 6
Project status: CLOSED

In order to help SMEs to fully realise their potentials and overcome market failures specific to them, public support to innovation in SMEs is available with a wide range of instruments and support services. At this point, innovation support agencies play a substantial role as intermediates for SME innovation by designing and delivering the innovation support programmes. However, despite the recent strong engagements and delivery of diverse innovation support schemes, addressing different innovation challenges, innovation support agencies still lack in a provision of evidence-based results which will demonstrate effectives of these newly developed schemes. Strengthening innovation management capacities in SMEs is defined as one of priorities of the future agenda for creating market-oriented innovation, but on the other hand, market potential of Social Innovation seems to become in the focus in the past year. Yet this kind of innovation is not well known and acceptance seems to be still low. With an aim of addressing these key challenges - creating an evidence-based innovation support scheme and comprising two central aspects (economic and social), DepoSIt Project objectives to develop a significantly improved innovation support scheme - Innovation Audit tool for Social Innovation and test it in a real environment conditions. By the application of Randomised Control Trial (RCT) method, six DepoSIt Project partners from six EU countries, active and experienced in design and delivery of innovation support programmes, will test the scheme by engaging min. 60 SMEs and in this way examine its effectives. Successful experimentation results will lead to the scheme validation and its upscaling. Furthermore, the Project aims to serve as a best practice example in this way to stimulate and deploy additional innovation agencies (min. 18) to become more effective and efficient in design, delivery and especially in experimentation of designed innovation support schemes.

Keywords: innovation support for smes,innovation audit,social innovation,randomised control trials
Genetic landscape of the homology search (RecPAIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-08
End date: 2021-06-07
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

The integrity of genetic information is central to life, yet the DNA is vulnerable to damage from internal and external sources. Incorrect repair of DNA damage drives mutagenesis, loss of genetic information, ageing, and cancer. Double strand DNA breaks (DSBs) are perhaps the most threatening DNA lesions, where the integrity of both strands of the DNA duplex is interrupted at the same position. In E. coli, faithful repair of DSBs is possible only through the homologous recombination (HR) pathway which uses replicated chromosome as a template to recover the information. At the center of HR lies an elusive search process, during which broken strand localises and pairs with the repair template. I will use a combination of CRISPR/dCas9 screening and in-situ genotyping of pooled library of strains to characterise the genetic landscape controlling the homology search. First, I will develop a low probability DSB induction method, to limit the DSB-formation to only a single chromosome per cell. Next, I will design and implement a whole-genome CRISPRi screen coupled to high-throughput sequencing and map the genes involved specifically in the homology directed repair of DSBs. The knowledge of the recombination-specific genes will allow to create a refined, high-quality phenotypic screen. In this screen the whole chromosome dynamics will be monitored and defects in the DNA movements will be characterised for each tested target with a microfluidic-based fluorescent microscopy. Each phenotype will be linked to a specific gene using the state-of-the-art in-situ phenotyping approach called DuMPLING. The functional characterisation of recombination genes will allow to conclude a molecular model of the search process in vivo.

Keywords: homologous recombination,whole genome screen,crispri,in situ genotyping
CoFutures: Pathways to Possible Presents (COFUTURES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Norway
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1319219.0
EU funding (EUR): 1319219.0
Participants: 1
Project status: SIGNED

This project investigates future fictions from five distinct traditions: Afrofuturism, Sinofuturism, Arab/Gulf-futurism, Latin@futurism, and Indofuturism. All these fictions respond to the burning issues of the present, the transnational discourses of demographic change, climate change, and technological change, but they imagine different, localized ways of engaging with these transnational discourses. Research Questions What contributions can contemporary future fictions make to our understanding of global issues? The project is split into three sub-questions to structure the enquiry: 1. What are the cultural and scientific bases for the development of different geography based future fictions? 2. What are the future changes – societal and technological – imagined in these future fictions? 3. How can we understand the response to global challenges – demographic change, climate change and technological change – in the local changes imagined in these futures? Based on this, the project will develop a theory of “COFUTURES” (Co: Complex –Coexisting –Comparative). Context The project studies the recent proliferation of fiction based on ethnic, cultural, or national identity as take-off points for imagining possible futures even if their locations of production are globally spread. While many of these have older histories, these fictions have come together in this decade as alternative visions of the future that are resistant to perceived colonial or neo-colonial hegemony and are read as new forms of self-assertion. No methodologies have been developed to study all these together as shared phenomena, and no theories exist that can even make sense of them as similar yet distinct phenomena. There have also been no attempts to understand the specific sources for these futures in terms of the kinds of scientific and technological developments they project and the societal developments they imagine as localized responses to global challenges. This is the COFUTURES aim.

Keywords: science fiction,afrofuturism,global science fiction,future fictions
Interactions between Groups, Orbits, and Cartans (IGOC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 1296966.0
EU funding (EUR): 1246761.98
Participants: 2
Project status: SIGNED

Recently, we discovered that the notion of Cartan subalgebras builds bridges between C*-algebras, topological dynamics, and geometric group theory. The goal of this research project is to develop our understanding of this concept in order to attack the following major open questions: I. The UCT question II. The Baum-Connes conjecture III. The conjugacy problem for topological shifts IV. Quasi-isometry rigidity for polycyclic groups UCT stands for Universal Coefficient Theorem and is a crucial ingredient in classification. I want to make progress on the open question whether sufficiently regular C*-algebras satisfy the UCT, taking my joint work with Barlak as a starting point. The Baum-Connes conjecture predicts a K-theory formula for group C*-algebras which has far-reaching applications in geometry and algebra as it implies open conjectures of Novikov and Kaplansky. My new approach to II will be based on Cartan subalgebras and the notion of independent resolutions due to Norling and myself. Problem III asks for algorithms deciding which shifts are topologically conjugate. It has driven a lot of research in symbolic dynamics. Conjecture IV asserts that every group quasi-isometric to a polycyclic group must already be virtually polycyclic. A solution would be a milestone in our understanding of solvable Lie groups. To attack III and IV, I want to develop the new notion of continuous orbit equivalence which (as I recently showed) is closely related to Cartan subalgebras. Problems I to IV address important challenges, so that any progress will result in a major breakthrough. On top of that, my project will initiate new interactions between several mathematical areas. It is exactly the right time to develop the proposed research programme as it takes up recent breakthroughs in classification of C*-algebras, orbit equivalence for Cantor minimal systems, and measured group theory, where measure-theoretic analogues of our key concepts have been highly successful.

Keywords: c algebras,cartan subalgebras,groupoids,k theory,topological dynamics,orbit equivalence,geometric group theory
Big Data for 4D Global Urban Mapping – 10^16 Bytes from Social Media to EO Satellites (So2Sat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-05-01
End date: 2023-01-31
Duration (months): 69.0
Total project cost (EUR): 1496500.0
EU funding (EUR): 1440250.0
Participants: 2
Project status: SIGNED

By 2050, around three quarters of the world’s population will live in cities. The new dimension of ongoing global migration into the cities poses fundamental challenges to our societies across the globe. Despite of increasing efforts, global urban mapping still drags behind the geometric, thematic and temporal resolutions of geo-information needed to address these challenges. Nowadays diverse sets of incomplete data exist. For example, Earth observation (EO) satellites reliably provide geodetically accurate large scale geo-information of the cities on a routine basis from space. But the data availability is limited by resolutions and acquisition geometries of the sensors. Complementarily, massive imagery, text messages and GIS data from open sources and social media are temporally quasi-seamless, spatially multi-perspective, but with diversely unknown qualities. With So2Sat I will jointly exploit big data from social media and satellite observations for global urban mapping, and aim at breakthroughs in 3D/4D urban modelling, infrastructure occupancy classification, and very high resolution population density mapping on a global scale for revolutionizing urban geographic research. The following methodological and application objectives will be addressed: improving urban-related information retrieval from EO satellite data (MO1), mining urban imagery and text messages from social media data (MO2), information fusion from heterogeneous data sources (MO3), big data processing (MO4), as well as pilot applications in informal settlements classification (AO1) and global population density estimation (AO2). The outcome of So2Sat will be the first and unique global and consistent spatial data set on urban morphology (3D/4D) of settlements, and a multidisciplinary application derivate assessing population density. This is seen as a giant leap for urban geography research as well as for formation of opinions for stakeholders based on resilient data.

Keywords: remote sensing,earth observation,urban geographic research,global urban mapping,signal processing,big data fusion,social media data
Coupling strategies for scavenging reactive C1 intermediates in hydrogen generation (COUPC1)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-11-30
Duration (months): 30.0
Total project cost (EUR): 204415.68
EU funding (EUR): 204415.68
Participants: 2
Project status: CLOSED

Recent findings have suggested the plausible involvement of formic acid (HCOOH) as a gaseous molecular shuttle in WGS reaction , which is specifically promoted by oxides (ZnO, CeO2, TiO2) that are known to selectively dehydrate HCOOH (microreverse of HCOOH formation from CO and H2O) and metals (Cu, Pt, Pd, Au) that do dehydrogenation (to CO2 and H2 in WGS) and hydrogenation (to methanol). The intermediate of interest (HCOOH) is formed in situ from CO/H2O mixtures on metals and oxides that catalyze selective HCOOH dehydration, and thus its microscopic reverse. Subsequent HCOOH dehydrogenation would lead to the formation of H2 and CO2, completing a water-gas shift (WGS ) turnover without requiring interfacial contact among functions. A notable promotional effect has been recently detected in catalyst without requiring atomic contact, meaning that the two functions need to be “close” but not in atomic contact but involving a molecular carrier. The mechanistic details of such diffusion-mediated routes would unveil new opportunities for the specific channelling of such intermediates towards H2 and CO2, through precise positioning of a function that forms HCOOH from CO/H2O reactants and another function, present beyond atomic contact but within diffusion distances, that dehydrogenates gaseous HCOOH to H2 and CO2. Summarizing, this research would permit controlling the WGS process in order to increase H2 production worldwide. The proposed research will address the formation and scavenging of reactive and thermodynamically unstable intermediates without a C-C bond, which can be formed from C1 molecules (specifically natural gas or biogenic feedstocks), through the precise positioning for their formation and scavenging functions. The researcher U. De La Torre will be seconded to the LSAC group at UC Berkeley (USA) under the supervision of Prof. Enrique Iglesia, and will return to the University of the Basque Country (Spain) under the supervision of Prof. González-Velasco.

Keywords: water gas shift,h2 generation,catalysis,c1 intermediates,hcooh
evolutionary platform to predict breast cancer (BC) patients outcome and response to therapy (BARRICADE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

“BARRICADE” is about an evolutionary platform to predict breast cancer (BC) patients outcome and response to therapy in a faster and specific manner. Breast cancer is one of the leading causes of cancer mortality among women and is characterized by a high interindividual variability in response to cancer treatment, and often resistance to therapy arise over the time or after first line of treatment. For this reason, the therapeutic approach of each patient has to be set up during its management causing some gaps, useless toxicities and a losing of time useful for patient’s cure. In cancer research, cells are usually grown in a monolayer on dishes of polystyrene plastic to perform experiment or toxicity studies. Alternatively, researchers use animal models that are able to mimic a more physiological growth of tumor cells and they take in account also the microenvironmental influences. Unfortunately, animal models do not recapitulate the human complexity, and sometimes they do not predict tumor behaviour and clinical response. For this reason, organoids are emerging as new more complex system that may overcome the limitations of traditional cancer model. “BARRICADE” will contribute to taking BC cancer therapy to beyond state-of-art, developing personalized anticancer therapies and giving useful information for cure setting up. Indeed, progress in developing in vitro 3D organoid culture system using primary human breast cancer tissues have attracted great interest as an emerging tools for precision medicine. BARRICADE will help to overcome some of those barriers by giving preclinical information for future therapy settings.

Keywords: breast cancer,personalized anticancer therapies