Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Remote Controllable Devices (RemoteControl Device)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Iceland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project is to commercialize Remote Controllable Trawl doors that will support Europe’s environmental and economic competitiveness by: 1. Improved catch performance resulting in higher efficiency in food production. 2. Lesser discards. 3. Reduced fuel consumption of vessels. 4. Less environmental side-damage and impact to the seabed. 5. Improved accuracy in seismic survey operations. With remote controlled spreading devices the crew doesn’t need to pull trawl doors and vanes on board to change their position underwater. They will improve the performance of the fishing gear and seismic survey with a remote controllable system on the spreading device for the benefit of improved operation, greater catching ability for fishing, more economical for both operations in terms of reduced fuel consumption, less time consuming, and less environmental side damage and impact to the seabed. The convenient remote control is what we envisage as a key market application. The identified business opportunities are based on the revolutionary solution for the benefit of improved operation performance and reduced cost. Owners of fishing vessels of 30 meters and longer are the potential customers. The worldwide market for traditional trawl doors is estimated close to € 100 million yearly. The potential “reachable” market for our solution is estimated close to € 70 million. The market for pelagic doors is approximately half of the total market, or € 35 million. The market for vanes on a yearly base is evaluated close to € 40 million. The solution will address both European and global markets. The specific objective for the feasibility study is to obtain a solid analysis of the potential market for the ‘Remote Controllable Spreading Devices’, in order to design an adequate market penetration strategy and ultimately to direct new investments. Phase 2 will include a 0,3 sqm model for Flume Tank tests and 5,0 to 6,0 sqm scaled prototype of ‘Remote Controllable Seismic Vanes’.

Keywords: catch performance,efficient food production,lesser discards,reduced fuel consumption,lesser environment damage,improved accuracy
Dissecting hippocampal circuits for the encoding of early-life memories (INFANT MEMORIES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1499055.0
EU funding (EUR): 1499055.0
Participants: 1
Project status: SIGNED

The infant brain is a formidable learning machine. But is it able to encode memories of early-life experiences? Since most of us don’t remember what happened during the first years of our lives, for a long time this question has been open to debate. Recent evidence suggests that, even if we cannot recall them, early-life memories are encoded in the developing hippocampus, persist in a silent state into adulthood, and can affect the acquisition of new information later in life. We know very little about how the infant brain encodes early-life memories, despite the fact that our earliest experiences can stick with us and influence our behaviour as adults. How can the infant hippocampus produce long-lasting memory traces when its circuits are not yet mature? Why can’t we remember early-life memories? And how can infant memories have long-lasting effects if we can’t recall them? To answer these questions, in the following project I propose to study memory processes in the developing brain using the mouse as a model organism. I will implement a combination of genetics, viral tagging, calcium imaging, and opto- and chemogenetic methodologies, in association with behavioural paradigms, to track in vivo the activity of a large number of neurons as the brain matures, and to gain fundamental insights into the early functions of the mammalian memory system. The aims of my proposal are: 1. to understand how the infant hippocampus produces neuronal ensembles to represent early-life experiences; 2. to identify and dissect the neural circuits encoding infant memories; and 3. to unravel how neurons supporting silent memories created during infancy influence learning processes in adults. By bridging developmental, systems, and behavioural neuroscience, my ambition is to understand how the developing brain encodes memories of early-life experiences, and how infant memories influence the operations of higher-order cognitive functions later in life.
A novel class of antibiotics to combat Antimicrobial Resistance (OMN6)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-07-01
End date: 2023-10-31
Duration (months): 28.0
Total project cost (EUR): 3413821.0
EU funding (EUR): 2389674.7
Participants: 1
Project status: SIGNED

We are in living in times where the efficacy of antibiotics is no longer guaranteed. Despite the urgent need to mitigate the spread of antimicrobial resistance (AMR), very few antibiotics are being developed. AMR management costs €1.5 B and causes 33,000 deaths each year in the EU. We at Omnix are determined to change lives and repopulate drug development pipelines by demonstrating clinical efficacy of a novel class of antibiotics. We have made potent antimicrobial peptides found in nature druggable, by hampering their biodegradability using our proprietary platform technology. The results are highly selective, life-saving therapies which are safe to humans. These bioengineered peptides constitute a new class of antibiotics due to their unique mechanism of action, which remains effective regardless of underlying resistance patterns. We intend to solve the most urgent clinical need in infectious disease management by targeting drug resistant pathogens topping the WHO’s priority list. The project will demonstrate clinical safety and efficacy in treating A. baunmannii infections. This top-most critical pathogen exerts a mortality rate of ~40%. We have already successfully established a preclinical proof of concept for our lead candidate. Commercialisation is planned to take place with a partner from the pharma sector. The deal size is predicted to be €150-250 and conservative estimates on sales forecast revenues around €50 M five years after launch. Revenues will be reinvested into developing antibiotics for other critical pathogens and into scaling Omnix to over 150 employees. Our approach has the potential to make a significant impact on the global AMR challenge, as we base our drug design on peptides that have remained effective for millions of years, demonstrating a low risk of trigger emergence of new resistance. Treating infections with such potent natural defenses will constitute a true paradigm shift in infections disease management.

Keywords: antimicrobial resistance,a baumannii,multi drug resistance,novel class of antibiotics,antimicrobial peptides,biomimetics
Built Environment Knowledge for Resilient, Sustainable Communities: Understanding Everyday Modern Architecture and Urban Design in the Iberian Peninsula (1939-1985) (ReARQ.IB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Portugal,Portugal
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1499613.0
EU funding (EUR): 1499613.0
Participants: 2
Project status: SIGNED

How can we manage, improve and develop resilient, sustainable communities, without a solid scientific knowledge of our built environment? Our everyday life is framed by a cohort of buildings about which we know very little, or nothing: they are outside of our cultural concerns, even though we reside, work, learn or convalesce in them. Understanding the architecture that shapes our everyday empowers our communities – it enables them to take informed decisions about what to preserve, reuse and replace; how to update and improve their buildings. At a time when resources are dwindling and must be used rationally, repurposing and retrofitting existing buildings is a priority over new construction, everywhere. European societies have a vast building stock at their disposal, erected in the second half of the past century, to be used and transformed: sturdy, pragmatic objects whose features are seldom discussed. ReARQ.IB bridges the gap between local communities in Spain and Portugal and their ‘architecture of proximity’: structures, ensembles and neighbourhoods generally left out of canonical historiography, close to our lives but far from our minds. Making the genetic fabric of this built environment clear, intelligible and operative is an essential first step for responsible management and decision-making by stakeholders. Contemporary architecture in both countries may be celebrated in professional circles, and even enjoy public visibility – but communities across the Iberian Peninsula, including many designers, know precious little about their modern built environment, which grew exponentially in the 20th century. Focusing on public-use and residential buildings – prevalent generic typologies that concern most communities – ReARQ.IB will integrate information and critical enquiry to support management and action while advancing architectural and urban history. This is applied science for community participation enabling a more sustainable and resilient built environment

Keywords: architectural culture,spain,portugal
Quantification of information flow in a cell signaling pathway (Cellinfo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Signaling pathways are cascades of biochemical reactions that transduce environmental signals to the cell interior. The cells rely on the information transduced through signalling pathways to govern biological functions and maximise the fitness of the organism. Conversely, defects in the signalling pathways are implicated in various diseases, e.g. carcinogenesis. The intricate network of signalling pathways indicates the existence of sophisticated information processing mechanisms, motivating the key questions of this project: How much information is transmitted from the environment through the signalling pathway? How many features of the signals are conveyed? Are signals integrated over time? To answer these questions, the project combines state of the art quantitative optogenetic experiments and theoretical modelling using information theory to quantify the information flow in the canonical MAPK signaling pathway. Experimentally, a well-defined stimulus will be applied at the beginning of the pathway while measuring the response at the end of the signaling cascade. The results will be integrated into a theoretical framework based on statistical physics and information theory to quantify how much static and dynamic information is being transmitted, offering key insights into cell function — the building blocks of living organisms — with potential application in drug design. The strong interdisciplinary nature of this project and the detailed dissemination strategy promotes collaboration between research communities of physicists and biologists, as well as reinforces information as a key concept in life sciences. The included training plan ensures the candidate will acquire skills in advanced experimental and theoretical techniques, and the two-way transfer of knowledge provides mutual benefit between the candidate and the host institution.

Keywords: erk signaling,mdck cells,optogenetics,information theory,modelling of cellular processes
Defining novel mechanisms critical for colorectal tumourigenesis (COLGENES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-08-01
End date: 2023-01-31
Duration (months): 66.0
Total project cost (EUR): 1498618.0
EU funding (EUR): 1498618.0
Participants: 1
Project status: SIGNED

Cancer genome sequencing has led to a paradigm shift in our understanding of oncogenesis. It has identified thousands of genetic alterations that segregate into two groups, a small number of frequently mutated genes and a much larger number of infrequently mutated genes. The causative role of frequently mutated genes is often clear and are the focus of concerted therapeutic development efforts. The role of those infrequently mutated is often unclear and can be difficult to separate from ‘mutational noise’. Determining the relevance of low frequency mutations is important for providing a full understanding of processes driving tumourigenesis and if functionally relevant may have broader implications on the applicability of targeted therapies. This project aims to begin addressing this by defining the function of all genes mutated in colorectal cancer (CRC) in the earliest stages of tumour formation. I have performed a whole genome screen in a 3D organoid CRC initiation model identifying several potentially important mediators of this process. Crucially, some of these genes are mutated in CRC at low frequency but not described as cancer driver genes. Thus, I hypothesize that rather than ‘mutational noise’ infrequently mutated genes contribute to CRC initiation. I will test this by addressing two aims: 1) Determine the role of genes mutated in CRC during tumour initiation 2) Validate and determine the function of a subset of identified genes potentially defining novel cancer mechanisms I will use a combination of CRISPR genetic disruption in state-of-the-art 3D mouse and human organoid cultures and advanced mouse models to address these aims. This comprehensive approach will provide a foundation for understanding the importance of the entire spectrum of mutations in CRC and open new avenues of research into the function of these genes. More broadly, it has the potential to make a profound impact on how we think about tumourigenic mechanisms and cancer therapeutics.

Keywords: colorectal cancer,cancer gene identification
Widening Research on Pervasive and eHealth - WideHealth (WideHealth)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Italy,Slovenia,North Macedonia,Portugal
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 899707.5
EU funding (EUR): 899707.5
Participants: 6
Project status: SIGNED

The WideHealth Project (Widening Research on Pervasive eHealth) will enable research exchanges and training activities on the topic of Pervasive and eHealth. The overarching goal of the project is to enable a new generation of researchers in the Widening Countries to develop and adapt novel eHealth technologies exploitable in the longer run in their different healthcare contexts. Also, the project will establish a sustainable network of knowledge research and dissemination across Europe in the Pervasive Health topic. The knowledge of requirements and available technologies for eHealth will be shared and become complementary between early-stage researchers and researchers in the target institutions involved in the twinning. This will allow researchers in Widening Countries to get trained and put this knowledge to use in their own context, improving potential of digitally enabled healthcare provisioning and impacting on both preventative medicine and alternative means of treatment. In particular, the project will address the following three research aspects: (i) data driven healthcare, (ii) human factors in pervasive health, (iii) federated machine learning. Additionally, WideHealth will include training of administrative staff to improve their skills on project management and administration of research funding. This way, the project will improve management and administration skills mainly for the coordinator UKIM, which is an important barrier to participating and obtaining European funding. The consortium includes partners from three Widening countries: UKIM - the coordinator - from North Macedonia, JSI from Slovenia, and FC.ID from Portugal. FC.ID - despite being from a Widening country - is a highly ranked university, so it will have a hybrid role, both receiving and providing expertise. The leading Institutions in this project are FBK in Italy and HPI in Germany, both of them recognized with high visibility in the Pervasive Health international research community.

Keywords: pervasive health,ehealth
New materials enabled by programmable two-dimensional chemical reactions across van der Waals gap (Programmable Matter)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 2748476.0
EU funding (EUR): 2748476.0
Participants: 1
Project status: SIGNED

Chemical reactions between solids are fundamental in areas as diverse as catalysis, information storage, pharmaceuticals, electronics manufacturing, advanced ceramics, and solar energy, to name just a few. Controlling the spatial extent of solid-state reactions at the nanoscale will enable development of materials, programmed on an atomic level, which will facilitate many emerging applications like bioinspired smart batteries and artificial synapses for future neuromorphic electronics. However, currently, there are no chemistry methods which allow precise spatial control at the nanoscale, limiting progress towards the programmable matter. Here I propose a completely new way to create novel materials using two-dimensional (2D) chemical reactions at the atomically-defined interfaces between crystalline solids. Usually, reactions between macroscopic solids are hindered as their large dimensions prevent placing them close enough to each other to support chemical transformations. Thus, just a few years ago, the task of placing two atomically flat crystals within angstrom proximity of each other, to initiate chemical interactions between them, was impossible to realise. This situation has changed dramatically with the advent of van der Waals technology - disassembly of various layered crystals into individual atom- or molecule-thick layers followed by a highly-controlled reassembly of these layers into artificial heterostructures. Building on our recent progress in van der Waals technology, I aim to realise interplanar chemical reactions between highly-crystalline solids in precisely controllable conditions using temperature, electric and magnetic fields, light, sound, pressure, and mechanical forces as means of control. Using digital control of 2D chemistry, mechanics, and electronics at the nanoscale, I and my team will develop programmable matter that actively responds to external and internal stimuli by adjusting their properties on an atomic level.
Molecular Machines Functioning in Cells (BIOMOLMACS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Spain,Switzerland,Belgium,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 4107786.48
EU funding (EUR): 4107786.48
Participants: 12
Project status: SIGNED

The main motivation of BIOMOLMACS training network is to establish a multidisciplinary training network on the emerging topic of molecular machines and to train the next generation of highly-skilled researchers in this exciting field. In the last decade, great efforts have been spent on the development of synthetic strategies for the creation of molecular machines, and these efforts have been acknowledged by the Nobel committee in 2016. In parallel, synthetic and polymer chemistry fields have made significant advances in the last decade, to the point that we are able to design and control the sequence of individual repeat units along synthetic macromolecules. Sequence controlled polymers open up greater possibilities in the precise formation of nanoparticles such as polymersomes, and even support the new generation of artificial cells. The synthetic combination of molecular machines and precisely designed synthetic macromolecules will open new avenues for innovative nanobiomedical applications. Early Stage Researchers of BIOMOLMACS will be trained on the design, chemical synthesis, and biophysical characterization of such complex macromolecular architectures as well as their incorporation in artificial and living cells. Finally, biophysical understanding of the molecular interactions in living/synthetic systems will be able to bridge the gap between fundamental and applied research in this exciting field.

Keywords: glycopolymers,biomaterials,polymersomes