Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tracing Ancient Grinding Technologies in the Neolithic - Bronze Age Transition (GrindTrace)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

Grinding technology (i.e. querns and handstones) is an integral part of the material culture of prehistoric societies, involved in numerous human productive activities, incorporating socioeconomic and cultural significance. For decades the study of grinding systems in the context of Greek prehistory remained limited with only a few exceptions. The GrindTrace project aspires to change the research landscape and enhance our knowledge regarding this understudied field, at the same time shedding light on the yet-little-known transitional period from the Neolithic to the Bronze Age. What first appeared to be a gap of about 500-700 years in the evolution of prehistoric societies in Greece, from the end of the 5th to the late 4th millennium BC, is now seen as the result of a combination of low visibility and insufficient research. The assemblage to be analyzed includes over 500 specimens originating from six sites in northern and central Greece. The following lines of investigation will be pursued: a) technological and functional study of the selected artifacts; b) experimental investigation of parameters influencing the grinding systems; c) petrographic characterization of the tools' raw materials; and d) combined analysis of contextual, spatial and temporal information. The proposed multidisciplinary approach integrates elements of archaeology, geology, GIS and tribology, and aspires to use the micro-scale to talk about the macro-scale (human behavior patterns, settlement organization, temporality of habitation). In this framework, I will have the chance to explore various analytical techniques, some of which are particularly underdeveloped. This will help me establish a novel methodological approach, which, besides boosting my potential to lead cutting-edge interdisciplinary research in the future, will contribute to the internationally growing functional studies, enhancing at the same time similar research prospects in the field of Greek prehistory.

Keywords: material culture,functional analysis,anthropology of technology,social relations and meanings
Translate and Adapt an Erotic Story in the Age of Printing - The Vernacular Tradition of Piccolomini’s Historia de Duobus Amantibus. Study and Critical Editions of the French and Italian Prosimetra (TrAdE-Pic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

The project aims at examining the vernacular tradition of the Historia de Duobus Amantibus, first written in Latin in 1444 by Enea Silvio Piccolomini. This novella is an example of literary and commercial success in the 15th-16th centuries: it was translated into many languages and circulated widely across Europe, both in its Latin and vernacular versions. The research will focus primarily on the French and Italian prosimetra, and study them within a comparative approach which will consider the cultural and book history, the impact of new readership on literature, the translation and rewriting processes, the changes in the depiction of characters (especially women). It will provide the first critical editions of these translations, the first complete analysis and the first comparative study of all the prosimetra. The research will embrace and develop actual disciplinary trends, which transcend the literary framework and consider the many historical, cultural, commercial and gender-related aspects. It will deliver an analysis resolutely anchored in the study, the understanding and the valorisation of the European heritage. Therefore, the work undertaken will expand our understanding of the literary, linguistic, historical-cultural aspects of the 15th-16th centuries, of the humanist construction, the book market, the exchanges between different areas and between society and cultural production. The project also intends to reach a public interested in cultural history and humanities studies. The tradition of the Historia de Duobus Amantibus is particularly able to attract a wide audience, as it is an erotic novella whose mechanisms of distribution and adaptation resonate with several current issues. It is therefore an ideal medium for communicating about literary and cultural history. It will also serve as a communication tool to explain the methodology used to edit old texts and provide information about philology and about what is read when reading an ancient text.

Keywords: rewritings vernacularisations cultural transfers book history book market depiction of women prosimetra enea silvio piccolomini historia de duobus amantibus antitus faure alessandro braccesi
Alcohol-induced arrhythmias studied by computational models of the human heart (ALCOHEART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 191918.16
EU funding (EUR): 191918.16
Participants: 2
Project status: SIGNED

Alcohol consumption is associated with an increased occurrence of arrhythmia and sudden cardiac death. Supraventricular arrhythmias, particularly atrial fibrillation (AF), are the most common arrhythmias associated with excessive alcohol intake, but ventricular arrhythmias have also been reported after alcohol intoxication. Alcohol-induced arrhythmias represent an increased healthcare risk for the patients, and if they do not self-terminate, hospital admission and subsequent cardioversion is necessary to restore the natural heart rhythm. Unfortunately, despite the known detrimental effects of alcohol consumption on human health and decades of extensive research in cardiac electrophysiology, the mechanism(s) by which ethanol promotes arrhythmias remain(s) poorly understood. This lack of knowledge considerably limits the ability to accurately identify individuals susceptible to alcohol-induced arrhythmias, and cardiac conditions that increase vulnerability to develop such arrhythmias. To unravel these mechanisms, the ALCOHEART project proposes a unique methodology that combines simulations in anatomically-accurate computational models of human atria and ventricles with the use of pharmacokinetic models that allow to simulate different alcohol drinking behaviours. The state-of-the-art computational models of atria and ventricles will allow to assess cardiac excitation and repolarization in 3 dimensions, and to characterize the contribution of ethanol to arrhythmia vulnerability in healthy and diseased hearts. Moreover, the simulations will allow to evaluate the role of different alcohol drinking behaviours between males and females, and of sex-specific differences in cardiac electrophysiology. Putting together leading experts in the field, the ALCOHEART project will offer new insights into arrhythmogenic mechanisms of ethanol, and will provide the researcher with excellent training for his future career.

Keywords: arrhythmia,cardiac electrophysiology,computer simulations,alcohol consumption
Fundamentals and Applications of Doped Organic Semiconductors (FADOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Sweden,Spain,Italy,United Kingdom,France,Switzerland,United States,Saudi Arabia
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 5094337.68
EU funding (EUR): 4666624.2
Participants: 27
Project status: SIGNED

The possibility to control electronic properties through doping is a defining property of semiconductors. As the surge in interest in doped organic semiconductors over the last decade was mainly driven by an interest in thermoelectric applications, focus lay largely on optimizing steady-state electronic properties of bulk materials. Here, we target spatio-temporal control over doping and combine this with a holistic view of doping, exploring the relation between doping and ‘all’ material properties, including thermal, mechanical and biological aspects. Not only allows this to solve urgent problems (contact resistance), it also enables completely new (switchable, reconfigurable) devices. The topic is inspired by a combination of scientific curiosity and a strong feeling of practical urgency, as reflected by the consortium composition of 8 universities, 4 research institutes and 4 companies. The latter jointly cover all major application areas of organic electronics, including light emission, photovoltaics, logic circuitry as well as instrumentation/modeling – each a multi-billion-euro market. The strong company involvement allows us to expose all doctoral candidates to academic and commercial working environments through a balanced secondment plan. Likewise, the training program complements the transfer of scientific skills (much beyond the specific topic, incl. open science) with personal and entrepreneurial skills, including communication to various audiences, career development, intellectual property and startup-founding, etc. On short to intermediate time scales, the impact of FADOS will be to enhance European competitiveness in major, growing markets–and beautiful science. On longer time scales, we expect that FADOS will open new fields in which the unique possibilities of soft semiconductors in terms of solution-based local and dynamic tuning of (opto)electronic, thermal, mechanical and biological properties are explored for truly new and green functionalities.

Keywords: machine learning
Advanced imaging techniques for assessing the potential of a cell therapy to improve the health of ex vivo perfused marginal kidneys (PerfusedKidneys)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

Kidney transplantation is the gold-standard for end-stage kidney disease (ESKD) but there is a shortage of organs. To increase organ numbers, kidneys from deceased donors aged over 60 are now often used. These so-called “marginal” kidneys are susceptible to the ischemic tissue damage that occurs during transplantation, and tend not to function as well, nor last as long, as kidneys from younger donors. Cell therapies administered into the renal artery prior to transplantation have potential to repair marginal kidneys. Adipose derived regenerative cells (ADRCs) are an attractive cell therapy because they can be isolated from the perinephric fat surrounding the donor kidneys, and can improve kidney health in rodent models. However, difficulties in evaluating ADRCs in human donor kidneys is a barrier to clinical translation. We need to monitor the biodistribution of the cells within the kidneys to ensure they do not form emboli, as well as measure the therapeutic effects of the cells on kidney function and tissue health. Recent technological advances in machine perfusion and imaging makes it possible to overcome these barriers. With machine perfusion, kidneys can be perfused outside the body (ex vivo) prior to transplantation, allowing their function to be assessed. Furthermore, a highly sensitive novel imaging technique called “magnetic particle imaging” (MPI), will enable the biodistribution of labelled cells to be determined with great accuracy. In this project, I aim to address these questions using marginal human kidneys that are not deemed suitable for transplantation. The University of Liverpool is uniquely positioned to host my project, being the only centre in Europe with expertise in both ex vivo perfusion as well as having an MPI scanner. If successful, my project could expedite the clinical translation of ADRCs and improve the performance of marginal kidneys. This would improve the lives of ESKD patients by keeping them off dialysis for longer.

Keywords: ex vivo kidney perfusion magnetic particle imaging stem cells
Networking food plant imports in Roman Italy (NetFoodIt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

The emergence of the Roman Empire marked a series of significant political and socio-economic changes across modern-day Italy as well as across a very large part of modern-day Europe. Among these, the establishment of a new transport network and the development of trade and commerce that this facilitated, was one of the most important and lasting changes. NetFoodIt aims at using imported food plants, for the study of Roman transport and movement and the socioeconomic dynamics that this established within the core of the Roman Empire and its broader surroundings, that is, across modern-day Italy. In doing so NetFoodIt will shed new light into the relation between mobility, commerce and the introduction of new tastes in Roman Italy. NetFoodIt will develop a geodatabase of Roman food imports assemblages and study their social access and rarity/regularity. In combination with the Roman transport network the project will next investigate the centrality of the sites with these imports, their character as consumption or redistribution centres and will reconstruct the routes for the distribution of these food plants. This will provide important insights into Roman commerce, economy and the extension and acquisition of new tastes as Rome expanded and developed contacts with other ancient cultures. In order to do so, a combination of novel techniques, which include Social Network Analysis, Site Rarity Index calculations, Spatial Network Analysis and spatial statistics will be employed in conjunction for the first time for Roman Italy. These methods and the training provided during their implementation by a team of leading international researchers will enhance the candidate's profile with cutting-edge techniques that will situate her at the forefront of research and boost her career.

Keywords: archaeobotany,roman archaeology,spatial analysis,network analysis
Unravelling nucleolar dysfunction in lymphocytes: from novel mechanism to diagnosis of (severe) combined immune deficiency (LYNCID)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 1499412.0
EU funding (EUR): 1499412.0
Participants: 1
Project status: SIGNED

LYNCID addresses critical gaps in our understanding of (severe) combined immune deficiencies ((S)CIDs), a group of debilitating inborn errors of immunity caused by T-cell dysfunction. Although over 100 (S)CID-causing genes are known, 30-40% of (S)CID patients remain molecularly undiagnosed, resulting in high mortality. Better knowledge and timely diagnosis of (S)CID represent critical unmet medical needs. Recently, my team has identified biallelic mutations in GTF3A, encoding transcription factor IIIA (TFIIIA), in (S)CID patients with early T-cell differentiation block. TFIIIA plays a critical housekeeping role by transcribing 5S ribosomal RNA, essential for ribosome assembly and nucleolar stress regulation. Intriguingly, patient-derived cells experience increased G2/M cell cycle arrest during chemically induced nucleolar stress, evidencing an impaired stress response. Based on this finding, I hypothesize that TFIIIA deficiency triggers (S)CID by impairing the nucleolar stress response, thus unveiling a completely novel disease mechanism still to be explored. Using TFIIIA-deficient patients as a model, alongside cellular and zebrafish models, LYNCID seeks to uncover the hidden interplay between nucleolar stress and (S)CID. We aim to 1) elucidate the role of TFIIIA in T-cell development and nucleolar stress response, 2) unravel nucleolar stress response in T-cell biology, and 3) develop the ‘Nucleolar Stress Index’, a diagnostic tool to detect altered nucleolar stress in molecularly undefined (S)CID patients. LYNCID spearheads (S)CID research by uncovering new (S)CID pathways and providing unprecedented insights into T-cell biology and nucleolar stress. We will develop cutting-edge diagnostics to improve patient care. Overall, by revealing the role of nucleolar stress, LYNCID will substantially advance our understanding of immune disorders and can open new therapeutic avenues in other nucleolar stress-related diseases including cancer and neurodegeneration.

Keywords: primary immune deficiencies,inborn errors of immunity,t cell lymphopenia,severe combined immune deficiency,nucleolar stress response
BUSINESS CASE ASSESSMENT FOR BIOCOAL MARKET UPTAKE (BCA-BIOCOAL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: other EIC
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Italy
Call: EIC Booster grant for EIC Pathfinder and EIC Transition grants (HORIZON-EIC-2024-BOOSTER-IBA-01, 2024)
Start date: 2024-12-01
End date: 2025-11-30
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: SIGNED

The proposed Booster Grant aims to expand the application of biocoal produced in the H2STEEL project beyond steelmaking to include cement manufacturing, potentially offering higher added value and significant carbon footprint savings. A comprehensive market analysis, technical and economic feasibility studies, and the development of a business case for biocoal in various industrial sectors are essential components of the proposal. Key activities include assessing the technical viability and market demand for biocoal, identifying strategic industrial contacts, and analyzing the impact of the European Trading Scheme on target industries. RE-CORD, leveraging its expertise and established infrastructure, will lead the assessment and experimental tasks, ensuring the project's alignment with EU sustainability mandates. The work package structure covers market assessment, strategy definition, and business case development. These will involve evaluating market dynamics, competitive landscape, financial viability, and operational strategies for biocoal introduction. The ultimate goal is to convince funding evaluators of the necessity to support the project for achieving a sustainable, profitable market rollout of biocoal, thereby extending the environmental and economic impacts of the H2STEEL innovations.

Keywords: business case assessment,market assessment,techno economic analysis
Metamaterial Interfaces for Quantum Electronics (METRIQS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Denmark,Spain
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-09-01
End date: 2031-08-31
Duration (months): 72.0
Total project cost (EUR): 13296910.0
EU funding (EUR): 13296909.0
Participants: 3
Project status: SIGNED

The quest to design materials with tailored properties is a driving force for new scientific and technological horizons and is critical for addressing the grand challenges of humanity. Our proposal introduces an innovative concept in condensed matter and materials science: heterostructures built upon the fusion of 2D van der Waals materials and freestanding transition metal oxides (TMOs), forming a new compound metamaterial where the interface itself plays a crucial and active role in the properties and functionality. Our strategy is threefold. First, by incorporating a 2D layer between two TMO crystals to prevent ionic-covalent bonding and disorder, we can stack the TMOs with a continuous, free choice of twist angle. This will dial in interfacial superstructures called moiré lattices, which impose profound changes in their physical properties. Second, the moiré lattices will ‘imprint’ ferroic orders in the interfacial 2DL, which then act as a spacer, lubricating layer, and sensing layer in one. Moiré engineering has so far been reserved for van der Waals materials, and with METRIQS, we seamlessly merge TMOs with van der Waals materials, creating a highly versatile hybrid platform, where the interaction strength, strain, and dislocation networks can be controlled. Moiré metamaterials are used to study valleytronics and correlated states, control skyrmions, realise spin-charge conversion devices, and control the nucleation of chiral molecules. Our most ambitious endeavour unfolds in the third phase, where we are committed to revolutionising material synthesis by design. This will be achieved through interface manipulation, employing a combination of static and dynamic techniques, including strain, light, and electric/magnetic fields, in conjunction with the precise control of the bilayer twisted oxide as a tuning knob. This project unites two separate scientific communities and material families, in a team with highly complementary skills, knowledge, and resources.

Keywords: metal oxides,perovskites,graphene,transition metal dichalcogenides,van der waals heterostructures,two dimensional materials,spintronics,valleytronics,correlated states,chiral molecules