Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Range of Electric SOlutions for L-category VEhicles (RESOLVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Italy,Italy,Austria,Austria,Germany,Germany,Spain,Italy,Austria,Italy,Poland,Czechia,United Kingdom
Call: Electric two-wheelers and new ultra-light vehicle concepts (H2020-GV-2014, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 6920277.0
EU funding (EUR): 6844027.0
Participants: 18
Project status: CLOSED

RESOLVE proposal aims at enabling the development of a range of cost-effective, energy efficient and comfortable ELVs (Electric L-category Vehicles) that will primarily attract ICE car drivers to switch to ELVs for daily urban commutes. EU cities are increasingly congested due to the demand and usage of motor vehicles that results in emissions and noise levels increase and scarcer parking, affecting the quality of life and health of city-dwellers. To tackle such issue, European-wide emission targets are becoming stricter and urban mobility plans are being drawn. Future scenarios for EU urban centres see a modal shift in personal mobility from cars to lighter, smaller, more specialised and environmentally friendly alternatives. ELVs are such alternatives that can cater to the average commuter’s needs because of their smaller size, lighter weight, lower on board energy requirement and thus smaller batteries, which supports lower costs and faster recharge. However this modal shift has not been without challenges: many car drivers do not consider LVs as a viable and comfortable option. To achieve that, the project will develop components and systems that meet the very low cost requirements for the segment, particularly modular and scalable LV-specific electric powertrains and battery architectures. At the same time the project will deliver an exciting and attractive ELV driving experience by proposing new concepts (tilting & narrow track), while keeping the vehicle energy consumption at very low level. All the advances will be demonstrated in two tilting four wheelers demonstrator ELVs (L2e and L6e category), though a large number of such advances will also be applicable to the complete range of ELVs (including powered-two wheelers). The RESOLVE consortium is optimally positioned to drive such innovations: PIAGGIO and KTM are the 2 largest LV manufacturers in the EU and the whole ELV value chain is represented, complemented by top component suppliers and universities.
Post-translational modifications during floral initiation: molecular dissection of the UFO-dependent LFY activation (PFIMDULA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-08
End date: 2019-06-07
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Flowering plants are the most successful plant group on Earth and provide the basis for most human and animal food. The development of flowers is dependent on a gene regulatory network orchestrated by LEAFY (LFY), the master transcription factor. In Arabidopsis as in other flowering plants, LFY activity is dependent upon its interaction with UFO, a member of the Skp1–Cullin–F-box E3 ubiquitin ligase complex. The goal of this project is to understand why LFY requires interacting with UFO to build flowers. For this, we will apply state-of-the-art technologies including mass-spectrometry, crystallography, biochemistry and plant developmental genetics to identify and characterize the function of Post-Translational Modifications (PTM) on LFY or LFY interacting proteins, with special emphasis on ubiquitination. After identifying key residues involved in the LFY-UFO interaction or targeted by PTM, their functional importance will be assayed in planta. This project should facilitate better understanding of the mechanism of LFY activation. LEAFY and the development of flower will be used here as a model to understand the “activation by degradation” mechanism, still elusive in most organisms and poorly studied in plants. Moreover, understanding the principles governing LFY activation should provide means to modify at will the architecture of plant inflorescences. This project builds on the current background of the applicant in the field of Mass-Spectrometry combined with the outstanding expertise at Grenoble and high-throughput facilities in Structural biology and plant developmental genetics. Notably, the applicant will work within one of the top French Research Centers and in a multidisciplinary environment that will allow the fellow to acquire complementary ‘new knowledge and skills’ in structural biology and developmental genetics. This will re-enforce the fellow’s background and professional maturity for employment opportunities in both academia and industry sectors.

Keywords: floral development,transcriptional factor,leaf,unusual floral organ,ubiquitination,post translational modifications,protein protein interaction,mass spectrometry,crystallization
Problems in Extremal and Probabilistic Combinatorics (PEPCo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 1800000.0
EU funding (EUR): 1800000.0
Participants: 1
Project status: CLOSED

Extremal and probabilistic combinatorics is a central and currently maybe the most active and fastest growing area in discrete mathematics. The field can be traced back to the work of Turán and it was established by Erdős through his fundamental contributions and his uncounted guiding questions. Since then it has grown into an important discipline with strong ties to other mathematical areas such as theoretical computer science, number theory, and ergodic theory. The PI proposes a variety of extremal problems for hypergraphs and for sparse random and pseudorandom graphs. The work for hypergraphs is motivated by Turán’s problem, maybe the most prominent open problem in the area. After solving an analogous question for graphs, Turán asked to determine the maximum cardinality of a set E of three-element subsets of a given n-element set V such that for any 4 elements of V at least one triple is missing in E. This innocent looking problem seems to be out of reach by our current methods and despite a great deal of effort over the last 70 years, our knowledge is still very limited. We suggest a variant of the problem by imposing additional restrictions on the distribution of the three-element subsets in E. These additional assumptions yield a finer control over the corresponding extremal problem. In fact, this leads to many interesting and hopefully more manageable subproblems, some of which were already considered by Erdős and Sós. We suggest a unifying framework for these problems and one of the main goals would be the development of new techniques for this type of problems. These additional assumptions on the hyperedge distribution are closely related to the theory of quasirandom discrete structures, which was pioneered by Szemerédi and became a central theme in the field. In fact, the hypergraph extension by Gowers and by Rödl et al. of the regularity lemma provide essential tools for this line of research.

Keywords: msc2010 05c65 hypergraphs,msc2010 05c80 random graphs,msc2010 05dxx extremal combinatorics
ASsembly and phase Transitions of Ribonucleoprotein Aggregates in neurons: from physiology to pathology. (ASTRA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Italy,Italy
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-03-01
End date: 2026-08-31
Duration (months): 78.0
Total project cost (EUR): 7741799.0
EU funding (EUR): 7741799.0
Participants: 2
Project status: SIGNED

Recent works indicate the pathogenic relevance of altered RNA metabolism and aberrant ribonucleoprotein (RNP) assembly in several neurodegenerative diseases, such as Amyotrophic lateral sclerosis. How defective RNPs form, what are their integral components and which events trigger their appearance late in life are still unsolved issues. While emerging evidence indicates that mutations and post-translational modifications of specific RNA-binding proteins (RBPs) induce liquid-solid phase transition in vitro, much less is known about the in vivo properties of RNP assemblies and which role RNA plays in their formation. ASTRA will combine sophisticated imaging-derived RNP complex purification with innovative computational approaches and powerful genetic tools to unravel the biophysical properties and composition of RBP complexes and how they are modified in disease conditions. Through the development of new imaging and optical methods we plan to study how RNPs separate in liquid and solid phases in cells, in tissues (retina) and animal models and to characterize their RNA and protein components in physiological and pathological states. Exploiting the novel finding that non-coding RNAs act as scaffolding molecules for RNP assembly, we will investigate how such RNAs control the dynamic link between RNP formation, intracellular sorting and function. In a genuine interdisciplinary team effort, we will reveal how the architecture and localization of cytoplasmic RNP complexes are controlled in motor neurons and affected in neurodegeneration. We plan to develop novel advanced microscopy methods to monitor formation of aberrant RNPs in vivo and we will explore new molecules to impede pathological cascades driven by RNP assemblies. In conclusion, ASTRA will allow us to gain a comprehensive understanding of RNP function and dysfunction; we will use this knowledge to develop new therapeutic strategies that will impact on several protein-misfolding neurodegenerative diseases.

Keywords: long non coding rnas and circular rnas
Development of energy management integrated circuits for any-many-multi micro energy harvesting (HarvestAll)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2022-07-31
Duration (months): 33.0
Total project cost (EUR): 3120556.25
EU funding (EUR): 2184389.38
Participants: 1
Project status: CLOSED

Creating battery-free “self-sustaining” sensor systems is a key requirement to realising the forecasted billions of interconnected sensors within the Internet of Things. Micro energy harvesting, scavenging energy from the ambient environment, through the use of autonomous micro energy sources (AMES), is an ideal solution; avoiding the need for regular battery replacement. Along with energy harvesters and energy storage, the major component in an AMES solution is an Energy Management Integrated Circuit (EMIC). The key technical challenges are that each type of energy-harvester has very different electrical characteristics and that the ambient energy is not available all of the time. A single EMIC is required that can effectively harvest from any energy harvester type. No such EMIC exists today. At Trameto, we are developing a patent protected portfolio of EMICs named ‘HarvestAll’. These devices will deliver any-many-multi energy harvesting functionality to permit applications to harvest all types of ambient energy now, enable the design and development of next generation AMES, and allow the creation of novel AMES applications that were not previously possible. HarvestAll products will be exported to global customers with whom we have built strong relationships through strategic and aggressive business development activities with the support of H2020, Innovate UK, and private seed-funded projects. Through our customer interactions, we have developed a number of fully qualified, early revenue case study opportunities which will allow us to showcase the functionality of our HarvestAll portfolio.

Keywords: internet of things,autonomous micro energy harvesting systems,ames,energy management ic,photovoltaic,electrodynamic,piezoelectric,thermoelectric,fabless,effective operating area
SCALABLE TECHNOLOGIES FOR BIO-URBAN WASTE RECOVERY (SCALIBUR)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Innovation actions
Countries involved: Italy,Spain,Spain,Italy,Italy,Germany,Spain,Germany,Italy,Spain,Belgium,Greece,Belgium,Sweden,Hungary,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Integrated system innovation in valorising urban biowaste (H2020-SFS-2018-1, 2018)
Start date: 2018-11-01
End date: 2022-10-31
Duration (months): 48.0
Total project cost (EUR): 11728483.61
EU funding (EUR): 9999391.39
Participants: 27
Project status: CLOSED

SCALIBUR creates a holistic consortium to cut urban biowaste and replace it with a new production chain of biomaterials, forming a partnership of end users to recover and transform biowaste from three municipalities, namely Madrid (ES), Albano (IT) and Kozani (EL), into value added products. During SCALIBUR a complete study of the quality, logistics and management schemes for municipal solid waste (MSW) and urban sewage sludge (USS) will be performed, to integrate innovative systems and technologies and obtain high-value biobased products. In SCALIBUR, HORECA waste will be transformed to proteins, lipids and chitin from insect rearing, while the organic fraction of MSW will generate biopesticides and bioplastics by high-solid enzymatic hydrolysis followed by fermentation. The resulting biogas from MSW and USS will be upgraded by bioelectrochemical treatment to produce commodity chemicals and bioplastics, such as PHBV. By cutting traditional linear waste management, new business models are created for the resulting circular value chains, applying a sustainable approach to generate new activities and benefits. These new profit sources will be created from a baseline analysis of existing waste management data and business models for each municipality, generating social innovation and favouring the adaptation and uptake of new opportunities along the entire urban value cycle. Continuous tests and development along SCALIBUR will create and fine tune new business models based on innovative processes, and feedback will be obtained from all stakeholders, in order to improve the definition, performance and integration of value, to minimize waste and maximize its benefit. With social engagement strategies, key communities will participate in all aspects of the new value creation, calibrating the returns of the project both for the generation of jobs and improved urban welfare, such as reducing the dependence from outside materials and the environmental impacts.

Keywords: waste collection,organic fraction,bioplastics,proteins,energy,business models,circle economy
Financing scheme for Energy Efficiency and Renewable energy Guaranteed in Deep renovations of building stock (FinEERGo-Dom)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Bulgaria,Poland,Romania,Slovakia,Latvia,Netherlands
Call: Innovative financing for energy efficiency investments (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-06-01
End date: 2023-11-30
Duration (months): 54.0
Total project cost (EUR): 1654338.75
EU funding (EUR): 1654338.75
Participants: 9
Project status: SIGNED

The National Fund “NFOSiGW” supported by KAPE and partners seek to replicate the financing scheme, systems and procedures developed for private and public sectors under the Latvian Baltic Energy Efficiency Facility’ “LABEEF”. The Fund will structure demand and execute the financing scheme of a pilot project through the existing online platform SHAREX. Partner organizations in Austria, Slovakia, Romania and Bulgaria will be replicating in their countries. The public funding will work as a leverage for ESCO to take on new projects without the need to wait for the repayment of already implemented projects. Therefore, their funds could be reinvested faster. The standardisation of procedures, expert verification of archived savings and increased amount of investments will motivate the financial sector to support energy efficiency and environmental protection projects. The standardisation and scaling up the number of investments in energy efficiency and environment protection will increase the trust of banks, increasing their involvement on the market. The support from public funds will aim at already implemented, successful projects assuring the repayment of invested public money in a long-term, providing the leverage effect in increasing the number of projects carried out by ESCOs and making the public funds available in the future for reinvesting. The stimulation of the ESCO market will help to utilise the potential for energy efficiency in the SME sector. The solution will work as a guarantee for energy savings and environmental effect which will be furtherly verified with the unified procedures implemented in the mechanism. Types of buildings and infrastructure included in the project (might be different in different countries): - multifamily private and municipal buildings, - public buildings, - individual residential buildings, housing communities, cooperatives.

Keywords: buildings,deep renovation,thermomodernisation,financial scheme,de risking
All-optical framework for the correlative imaging of cardiac meso-scale cytoarchitecture and multi-scale electrical conduction (Optoheart)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Myocardial infarction (MI) is a key risk factor for sudden cardiac death, a leading global cause of mortality. Understanding how altered tissue architecture in MI influences cardiac electrical conduction is crucial to develop therapies which treat abnormal heart rhythms (arrhythmias) clinically. Optical measurement of transmembrane voltage in cardiac muscle is a versatile, non-invasive tool to investigate myocardial conduction. However, the current techniques of wide-field and multiphoton imaging have individual limitations restricting their ability to study key features of conduction in a 3D framework. Furthermore, optogenetics cannot be easily implemented in imaging platforms due to spectral overlap with the activation of light-gated ion channels such as channelrhodopsin. Combining all 3 techniques will provide a platform to study electrical conduction within mammalian myocardium in a 3D context and will be capable of quantifying effects introduced by tissue heterogeneity such as vasculature and scar tissue. The proposed project combines development of novel imaging technology with applied cardio-(patho)-physiology to study cardiac conduction at tissue interfaces in intact hearts with an innovative correlative approach. A new all-optical platform will be developed to simultaneously measure and stimulate cardiac activity, with the capability for real-time stimulation using custom optical patterns. Conduction will be mapped experimentally across structurally distinct regions and depths in healthy and MI hearts. This data will be correlated with underlying cytoarchitecture in the same hearts by employing tissue clearing in combination with novel light-sheet microscopy for imaging of structurally intact whole organs. This work will realise a new platform to study conduction in 3D microstructural context and deliver proof-of-concept data to address key questions concerning electrical behaviour in healthy and diseased hearts.

Keywords: microscopy,correlative imaging,optogenetics,cardiac electrophysiology,fluorescence,light sheet microscopy,tissue clearing,arrhythmia,cytoarchitecture,wide field,multiphoton microscopy
Advance atomic-scale simulation solutions (SIESTA-PRO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-10-01
End date: 2019-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The business opportunity detected is that currently no company offers professional support for an "open source" code nor a code capable of covering all the needs of the industrial field, with support, guarantee and usability comparable or even better than existing commercial alternative software. SIMUNE takes as a starting point a code developed by the founders of SIMUNE and popular in the scientific community (SIESTA), with the aim of adding improvements and functionalities and as consequence make it competitive versus any existing code right now in the market. The advantages that the solution brings to the customers are: • Save costs thanks to the efficiency of the code (3/4 times faster than existing solutions) • Capable of analysing large systems (up to thousands of atoms), which is innovative in the market • Reduce the time to market of new materials, accelerating their development stage; • Understanding of the “why” of the results of the measurements (testing) and gives prediction of (next steps) • To analyze, explore and characterize properties of materials that by other means would not be possible • To study complex physical and chemical phenomena simplifying them in fundamental parts, treatable by computer simulations SIMUNE proposes SIESTA-PRO in order to take the use of specialised expertise, highly recognised SIESTA code and all the powerful computational tools a step closer to the market. SIMUNE will start with three niches: Chemicals (e.g. BASF), Electronics (e.g. INFINEON) and Bioscience (e.g. MERCK) market niches. This will have a direct impact in how advanced material industry perform new material developments, which impacts the global economy, and at the same time will lead SIMUNE to become the worldwide reference During the Phase 1, a feasibility assessment will be conducted by having three independent channels of information gathering and analysis. With the results and data gathered in this study a Business Innovation Plan will be ellaborated.

Keywords: atomic scale simulation,new materials,material development