Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Harnessing the power of bioinformatic analysis to improve genetic selection for fertility in dairy cows (Bioinformatics4Breeding)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Genetic selection for high yielding dairy cows has been associated with reduced fertility. Infertility remains the major reason for culling, decreasing longevity and reducing production efficiency. We propose that this trend could be reversed by identifying key genes involving reproductive function and selective breeding of more longlasting cows. The specific research objectives are: 1) to train the incoming researcher in bioinformatics methodologies related to analysis of large genomic datasets including SNP detection, genotyping, and evolutionary conserved DNA elements detection; 2) to use the methodologies to analyse dairy phenotypic and genomic data to highlight potential genic and regulatory regions of the cattle genome containing polymorphisms which are beneficial, with a particular focus on fertility; 3) to use appropriate tools to investigate the likely effects of both coding and regulatory variants on the expression of the candidate genes found in these regions; 4) to use pathway analysis to understand how the candidate genes may influence key molecular events and larger gene networks involved in reproductive phenotypes; 5) to recommend appropriate selection procedures to the EU dairy breeding industry to supplement current genomic methods. The project combines the expertise of Consiglio per la Ricerca in Agricoltura e l’analisi dell’Economia agraria, Italy (CREA) and the Royal Veterinary College, UK (RVC) in farm animal genetics and genomics and dairy cow production. The objectives will be met by the mobility of Dr L Buggiotti to the UK, where she will work closely alongside two senior RVC scientists, Dr DM Larkin and Professor DC Wathes. She will transfer this expertise back to CREA on her return. Both groups are experienced in knowledge transfer to the dairy industry and are committed to use the information generated to breed more fertile cows, so improving longevity and promoting sustainability of the EU dairy industry.

Keywords: breeding,fertility,dairy cows
Algebraic Covering Codes Enabling Network Transmissions (ACCENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Applications of rank-metric codes arise ever more frequently in network communications problems, and yet their mathematical theory is still in its infancy. To date attention has almost exclusively focussed on very special classes of codes and their generalizations. The covering problem for rank-metric codes is largely unsolved, and is an important combinatorial research topic. For error-free paradigms, codes with low covering radius provide efficient solutions for broadcast problems, and specifically to optimizing content delivery networks for large files distribution. Current approaches to such applications are suboptimal, while known methods to obtaining best possible performance are computationally infeasible. For error-correcting schemes, the covering radius is an important indicator of code performance, as it measures the number of errors that can be corrected in network transmissions. We propose to develop a mathematical theory of covering codes for the rank metric. We will obtain bounds on the covering radius of an arbitrary rank-metric code, as well as special classes of codes. We will develop the fundamental tools required to pioneer this theory, offering scope for researchers of Algebraic Coding Theory, as well as combinatorial objects useful for Engineering applications. We will also investigate symmetric rank-metric codes, focussing on their distance distributions. These codes have a very rich combinatorial structure. The combined expertise of the Applied Algebra group at UCD, along with the methods developed by the applicant in his PhD, will propel the project to achieve its objectives. The potential scientific impact is high, given the newness and combinatorial hardness of the topic, its importance for network communications, and exponentially increasing data traffic. The impact for the applicant will be the opportunity to establish this fundamental topic, magnify his scientific profile, and consolidate/expand his professional network.

Keywords: coding theory,network coding,finite fields,rank metric code,covering radius,newton radius,rank distribution,codes performance,symmetric code,symmetric bilinear form
Local training network: Netherlands Earth System Science Centre: “NESSC” (NESSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 2820480.0
EU funding (EUR): 1410240.0
Participants: 1
Project status: SIGNED

Forecasting the magnitude of future global warming is among the great scientific challenges. Model estimates of long-term warming resulting from a doubling of the CO2 concentration relative to the pre-industrial era range between 1.5 and 4.5 °C. This large uncertainty may represent the difference between the melting or conservation of large continental ice sheets, and between habitable and inhabitable regions. NESSC, the Netherlands Earth System Science Center, addresses climate-related research questions, dealing with past, present and future interactions between the geosphere, biosphere, hydrosphere, cryosphere and atmosphere. Specifically, NESSC studies the response of the Earth System to perturbations and will merge information obtained from past climate, using climate proxies, with data and models for the modern climate. NESSC brings together renowned experts in the fields of palaeoclimate proxies, climate reconstructions, biogeochemistry, microbiology, and theory and modelling of climate. These experts join forces to obtain novel insights in climate research. All scientists involved have ample experience with supervising PhD students and leading successful research groups. Through COFUND NESSC will expand its research and training programme internationally, with an additional 13 Early Stage Researchers. NESSC will significantly advance our understanding of the Earth System functioning in the future. The COFUND programme is tightly connected with multiple national and international partner organisations, each providing complementary research and/or training. Through COFUND NESSC will maintain and further expand its excellent worldwide position.

Keywords: climate research,tipping points,doctoral training,multidisciplinary programme
Triplet Energy Transfer at Hybrid Organic-Lanthanide Nanoparticle Interfaces (TET-Lanthanide)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The generation, control and transfer of triplet excitons in molecular and hybrid systems is of great interest for optoelectronic applications such as light emission, singlet fission and upconversion, as well as for sensitization and triggering photochemical reactions. Recently, the host group has discovered that it is possible to couple molecular triplet excitons to the f→f transitions of lanthanide nanocrystals, efficiently transferring energy between them. This allows for the direct generation of triplet excitons with near-IR excitation and luminescent harvesting of the dark triplet excitons via transfer to lanthanide nanocrystals. This discovery also opens up a promising new avenue for photochemistry/photocatalysis applications, as LnNPs are both non-toxic and highly photostable even within aqueous environments. The project will build on this discovery to develop the fundamental science of this new platform for optoelectronics and photochemistry. Specifically, we will develop a series of highly controlled solution phase systems, where organic molecules will be directly covalently attached to the lanthanide nanocrystals. The lanthanide doping concentration of the nanoparticles, as well as the distance between organic and lanthanide will be carefully controlled to produce model systems. These systems will then be studied with steady state and time resolved spectroscopy with the aim of elucidating the underlying mechanism controlling the triplet exciton transfer and coupling between triplets and lanthanide ions. We will also perform a proof of concept experiment to demonstrate the use of these systems for photo-catalysis. These fundamental investigations will open up new possibilities for optoelectronics, molecular sensing, upconversion, photocatalysis and bio-imaging.

Keywords: triplet,energy transfer,lanthanide,organic semiconductor,nanoparticles
A portable instrument (PINE) for the autonomous detection of atmospheric ice nucleating particles aimed at the research, global monitoring and cloud seeding markets (CountIce)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-02-01
End date: 2022-04-30
Duration (months): 27.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

It is becoming increasingly clear that a class of atmospheric aerosol particles which catalyse ice formation have a profound impact on clouds, precipitation and climate. For example, recent research demonstrates that massive cloud systems the size of Western Europe are almost completely removed by sufficient ice nucleating particles. However, the global distribution of ice nucleating particles is extremely poorly characterised, in part due to the lack of instrumentation which can be used for the autonomous quantification of these important particles. In my ERC Consolidator grant (MarineIce) we have developed the first instrument to automatically measure atmospheric ice nucleating particles: the Portable expansion chamber for Ice Nucleating particle mEasurements (PINE). PINE allows the repeated formation of an artificial cloud and counting of resulting ice crystals which allows us to derive the ice nucleating particle concentration. The overarching goal of CountIce is to demonstrate that the PINE chamber can indeed be used to quantify the ice nucleating particle concentration in the atmosphere while being autonomous, easy to use, have high sensitivity and low background counts, have a high time resolution, and work over a wide range of temperatures (relevant to the full spectrum of clouds that form in the Earth’s atmosphere). CountIce will therefore create value in PINE, allowing us to take the necessary steps towards commercial products which will be aimed at i) the atmospheric research community; ii) the cloud seeding community and the iii) the global atmospheric monitoring networks. CountIce will give my team the time and resources needed to adapt and develop PINE into an instrument which meets the needs of paying customers, provide the demonstration of its use in an atmospheric observatory, produce technical marketing materials, assess significant markets and develop an evidence based business plan.

Keywords: ice nucleating particles,cloud,cloud glaciation
International Randomized Study Comparing personalized, Risk-Stratified to Standard Breast Cancer Screening In Women Aged 40-70 (MyPeBS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Israel,Italy,Italy,Italy,Italy,Italy,Belgium,Belgium,France,France,France,France,France,France,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Comparing the effectiveness of existing healthcare interventions in the adult population (H2020-SC1-2017-Two-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2026-06-30
Duration (months): 102.0
Total project cost (EUR): 12498983.75
EU funding (EUR): 12436858.75
Participants: 32
Project status: SIGNED

MyPeBS addresses the crucial and timely question of the future of breast cancer screening in Europe. Indeed current standard mammographic screening, with entry stratified by age alone, has recently been largely questioned. Despite a demonstrated mean 20% reduction in breast cancer-specific mortality, together with reduction of late-stage disease in women older than 50, it is associated with potential harms including false positive recalls and over-diagnosis. Individual breast cancer risk estimation, through models including clinical variables, mammographic breast density and more than 100 genetic polymorphisms, now has substantial clinical and scientific bases. Personalized screening strategies, based on individual risk levels, could potentially improve the individual benefit/harms ratio of screening (earlier cancer detection and less intensive treatments in high risk women, less false positives and over-diagnoses in low risk ones), and increase the cost-efficacy for health insurances. MyPEBS will conduct an international randomized phase III trial to validate this hypothesis. It will primarily assess the ability of an individual risk-based screening strategy to be non-inferior, and possibly superior, to the standard of care screening, in reducing the cumulative incidence of stage II+ breast cancers. The trial, conducted in 5 countries (France, Italy, UK, Belgium and Israel) will include 85000 European women aged 40-70, all followed for 4 years. MyPEBS will also evaluate if an individual risk-based screening strategy, compared with the standard, reduces screening-related harms (unnecessary biopsies, overdiagnoses) in low-risk women, is overall at least as cost-effective as well as more accepted by women resulting in a larger screening coverage. After analyses of all components, the final objective of MyPEBS is to deliver recommendations for the best future breast cancer screening strategy in Europe.

Keywords: breast cancer,screening,personalised,risk based,risk score,polymorphisms,genetics,mammography
RESILENS: Realising European ReSiliencE for CritIcaL INfraStructure (RESILENS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Research and Innovation actions
Countries involved: Ireland,Ireland,Germany,Germany,Israel,United Kingdom,United Kingdom,Portugal
Call: Crisis management topic 7: Crises and disaster resilience – operationalizing resilience concepts (H2020-DRS-2014, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 4091842.5
EU funding (EUR): 4091842.5
Participants: 12
Project status: CLOSED

Critical infrastructure (CI) provides the essential functions and services that support European societal, economic and environmental systems. As both natural and man-made disaster and crises situations become more common place, the need to ensure the resilience of CI so that it is capable of withstanding, adapting and recovering from adverse events is paramount. Moving resilience from a conceptual understanding to applied, operational measures that integrate best practice from the related realm of risk management and vulnerability assessment is the focus of the RESILENS project. RESILENS (Realising European ReSILiencE for CritIcaL INfraStructure) will develop a European Resilience Management Guideline (ERMG) to support the practical application of resilience to all CI sectors. Accompanying the ERMG will be a Resilience Management Matrix and Audit Toolkit which will enable a resilience score to be attached to an individual CI, organisation (e.g. CI provider) and at different spatial scales (urban, regional, national and transboundary) which can then be iteratively used to direct users to resilience measures that will increase their benchmarked future score. Other resilience methods including substitution processes and measures to tackle cascading effects will also be developed. The ERMG and resilience management methods will be tested and validated through stakeholder engagement, table-top exercises and three large-scale pilots (transport CI, electricity CI and water CI). The ERMG and accompanying resilience methods will be hosted on an interactive web based platform, the RESILENS Decision Support Platform (RES-DSP). The RES-DSP will also host an e-learning hub that will provide further guidance and training on CI resilience. Overall, RESILENS aims to increase and optimise the uptake of resilience measures by CI providers and guardians, first responders, civil protection personnel and wider societal stakeholders of Member States and Associated Countries.

Keywords: resilience,critical infrastructure,ermg,resilience management matrix and audit tools,resilens e learning hub,substitution processes,cascading effects
A new tool for creating real-time music within computer games (CALMUSgaming)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Iceland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Computer games are experiencing an incredible fast evolution. With around 2.2 billion gamers across the globe (25% of the European on-line population plays video games) the industry has a constant demand for new technology, essential to maintain players’ interest in a very demanding market. Music, as a crucial part in the computer games creation process, also requires the new videogame era: whereas old computer games were, in general, simple (often just requiring a single melody), current ones are deeply complex, with several plots and levels, and almost infinite potential scenarios. However, current approaches for music composition do not adapt to this non-lineal essence of games but are just based on looping static musical pieces for each game level. This results in repetitive soundtracks, uninteresting for players, and a time-consuming activity for composers, unable to create a soundtrack for every single potential scenario. Based on the previous success of our CALMUS technology (that facilitates real-time adaptation of music composition to diverse external stimuli), we now present CALMUSgaming. CALMUSgaming is an innovative tool for automatically creating and adapting music within computer games. Instead of the soundscape being perpetually repeated, it enables a constant and real-time adaptation of the background music, according to how game progresses and to the player's performance and actions. On the one hand, CALMUSgaming facilitates music composition for computer games: it automatically generates complex and dynamic themes saving up to 90% of composition time. On the other hand, it enriches players’ experience, as it changes constantly as the game progresses. ErkiTónlist is an Icelandic SME focused on promoting creative endeavours in music. Grown over the achievements of our CALMUS technology, and out of our collaboration with CCP Games (one of the on-line games leaders worldwide) we have now found a great opportunity to enter the computer games industry.

Keywords: computer game,real time music,video game,soundscape
The Power of Silence: A Medical Anthropological Approach to AIDS Care Narratives (AIDSsilences)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 174864.6
EU funding (EUR): 174864.6
Participants: 2
Project status: CLOSED

Despite the widespread availability of antiretroviral medication, the global AIDS epidemic has not been halted yet and stigmatization of people living with HIV and AIDS continues in most parts of the world. While the social scientific analysis of narratives of people living with HIV/AIDS (PLWHA) has proven crucial in understanding challenges in AIDS care worldwide, the silences that structure such narratives remain under-theorized. Current studies signal that silences may be defenses and active strategies rather than passive responses to stigma, but critical questions remain on how to study, conceptualize and interpret what is unspeakable and unspoken, and sometimes even unthinkable. This project develops novel analytical tools to understand silences in illness narratives. It is based on empirical data gathered in Indonesia and New York. Its objectives are threefold: 1) To conceptualize how silences shape AIDS care, by analyzing narratives of PLWHA and caregiving institutions (conceptual/empirical goal) 2) To theorize the relation between silence and narrative (theoretical goal) 3) To develop a qualitative methodology for recognizing, inquiring into, and understanding respondents’ silences (epistemological/methodological goal) In order to reach these objectives, the researcher will receive advanced training at Harvard University, which is on the forefront of developing multidisciplinary scientific research on HIV/AIDS and narrative theory. The expertise developed at Harvard University will strengthen the medical anthropology program of the University of Amsterdam, which houses the return phase of the project. The project will enhance the career opportunities of the researcher and promises to make significant contributions to the understanding of narratives and silences in AIDS care. These insights are highly relevant for policymakers in the global fight against AIDS and for social scientists who work in the field of global medicine.

Keywords: medical anthropology,aids,care,narrative,silence,indonesia