Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Global Response Against Child Exploitation (GRACE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Ireland,Germany,Germany,Spain,Cyprus,Lithuania,Belgium,Poland,Romania,Greece,Greece,France,Netherlands,Netherlands,United Kingdom,Portugal
Call: Technologies to enhance the fight against crime and terrorism (H2020-SU-SEC-2019, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 6824012.5
EU funding (EUR): 6823512.5
Participants: 23
Project status: SIGNED

The use of the Internet to distribute CSEM is an abhorrent crime. Referrals from Online Service Providers are key to fighting CSE. OSPs, detection technologies and users reporting suspicious material are improving. However, this leads to an increase in the sheer volume of referrals coupled with the increase in the distribution of CSEM online that is pushing MS LEAs to their limits and affecting their their capacity to prevent harm to infants and children, rescue those in immediate danger, and investigate and prosecute perpetrators. The NCMEC process has improved LEA capability. But, a typical CSE case contains 1-3 TBs of video, 1–10 million images. Limited human resources, manual analysis and the 4,000% increase in referrals since 2014 obligates a new approach. GRACE will apply proven techniques in ML to the referral and analysis process while embracing the very technical, ethical and legal challenges unique to fighting CSE. GRACE will leverage resources already in place at EUROPOL and its 9 MS LEAs and attempt to provide results early, frequently and flexibly, prioritising easy wins in the research plan (e.g. deduplication). By applying Federated Learning approach to the challenge of optimising analysis and information flow, GRACE will enable cooperation between LEAs in improving their own capabilities and harness experiential knowledge. The results of GRACE will be handed back to EUROPOL and MS LEAs for unrestricted use in their missions, helping to ensure their future technological autonomy.

Keywords: csem,nmec,computer vision,federated learning,data analytics
Cultural Codes in Crisis: Unsettled Civil Spheres in Brexit, the 2016 US Presidential Election, and the 2017 German Federal Election (CODE_FLUX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2024-03-31
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

Populism, ethno-nationalism, and isolationism have rippled through recent elections in Western democracies, unsettling the multicultural, globalist, and neoliberal trajectories many had assumed were durable and determined. Brexit in the UK, Donald Trump’s victory in the USA, and the strong showing of the Alternative for Deutschland (AfD) in Germany’s 2017 federal election upended the conventional wisdom and drew deep cultural and social cleavages to the fore. This study approaches these developments as manifestations of severe challenges to foundational cultural elements that control, anchor, and organize liberal, Western democratic social orders. By investigating these dueling political campaigns and press coverage that narrated these three democratic votes, this project examines the scope and intensity of these challenges. The study focuses on meaning structures, or cultural codes and justification narratives, that these events’ principal actors performed in effort to move citizens to vote, and specifies the interpretive resources citizens drew upon to justify their voting actions. In effort to innovate methodologically, the study uses two frameworks to investigate each of these sites, one qualitative, called structural hermeneutics, and one a quantitative, digital technique called computational hermeneutics. Through its investigation of Brexit, the rise of Trumpism and the 2016 US presidential election, and the rise and institutionalization of the AfD in Germany, this study addresses issue of the foundational elements of culture, and explains how these structures came to be agitated into a state of flux.

Keywords: civil society,populism,cultural sociology,political communication,elections,democracy,mixed methods
Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies (OUTstandINg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The MSC OUTstandINg project will use bioorthogonal click chemistry as tool to covalently attach magnetic nanoparticles (MNPs) to living cell surfaces with the aim to address two fundamental questions in the field of magnetic hyperthermia therapy using MNPs: 1) how the subcellular localization (on the plasma membrane or inside the cells) of MNPs affects their heating behaviour when compared to MNPs in solution 2) how MNPs immobilization and sub-lethal magnetic hyperthermia impact different subcellular signalling pathways and the biophysics of cell membranes. OUTstandINg is a multidisciplinary two-years research project built upon the expertise of the Fellow (Dr. Raluca M. Fratila) in bioorganic chemistry (including click chemistry, bioconjugates and functionalization of surfaces and (nano)materials) and the experience of the supervisor (Dr. Jesús Martínez de la Fuente) and of the host group (GN2 - Nanotherapy and Nanobiosensors, University of Zaragoza, Spain) in nanotechnology and nanomedicine. This MSC action will offer the Fellow the possibility to work in one of the top European institutions in nanoscience, where she will further develop her skills and will acquire new skills and knowledge necessary for the progress of her scientific career towards an independent position. The secondment period at University College London Institute for Biomedical Engineering (supervisor Prof. Quentin Pankhurst) will reinforce and complete the multidisciplinary training-through-research. The project will generate important knowledge and collaborations in the European Research Area (ERA) and will contribute to enhance the excellence of ERA through cutting-edge research at the frontier of chemistry, physics, materials science, cell biology and nanotechnology.

Keywords: bioorthogonal click chemistry,magnetic nanoparticles,magnetic hyperthermia,nanomaterials cells interactions
Value added materials from organic waste sugars (VAMOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Austria,Ireland,Italy,Germany,United Kingdom,United Kingdom,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Valorise sugars from the cellulosic and/or hemicellulosic fractions of lignocellulosic biomass (H2020-BBI-JTI-2018, 2018)
Start date: 2019-09-01
End date: 2023-08-31
Duration (months): 48.0
Total project cost (EUR): 12860745.5
EU funding (EUR): 6984812.88
Participants: 13
Project status: SIGNED

This project aims to showcase, at demonstration scale, the feasibility of producing and valorising second generation sugars derived from municipal solid waste (MSW). This MSW is composed of either mixed domestic residual waste or waste rejected from sorting and recycling processes (MRF rejects) and contains significant quantities of paper/card (lignocellulosic) based materials. The sugar will be utilised in the production of three bio-based products; 1) a thermoset bioresin used in the binding of mineral-wool insulation; 2) purified lactic acid (LA) for the commodities market; and 3) poly-lactic acid (PLA) and PLA/Fibre composite materials to be used in non-food contact applications within the fast moving consumer goods (FMCG), packaging, furnishings and construction sectors. The vision is to create a paradigm shift in industrial biotechnology products by establishing a novel approach based on the efficient use of low value mixed waste and the conversion of this material into value-added products. This project, titled ‘Value Added Materials from Organic waste Sugars’ (VAMOS) aims to produce competitive, sustainable, affordable and high-performance bio-based materials from low-value residual waste sugars.

Keywords: lignocellulose,cellulosic sugars,bio products,biomass
Collaboration for innovation: Establishment of a pan-nematode drug development platform (HELP)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Switzerland,Switzerland,Tanzania, United Republic of,Switzerland,France,Cameroon
Call: New anti-infective agents for prevention and/or treatment of neglected infectious diseases (NID) (H2020-SC1-2018-Two-Stage-RTD, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 8713395.42
EU funding (EUR): 8713395.42
Participants: 8
Project status: SIGNED

To target helminth elimination, a drug research and development (R&D) pipeline is needed to provide new chemotherapeutics that effectively eliminate or sterilize adult worms, thus bringing about the paradigm shift necessary to reach the 2030 SDG goals on health. Our consortium proposes to establish a R&D pipeline for anthelminthics targeting nematodes. The focus will be on soil-transmitted helminthiasis and onchocerciasis, since these infections are among the leading neglected tropical diseases. Ground breaking characteristics of the drugs developed within our project are that they will have a unique mechanism of action that, at best, will target multiple nematodes (pan-nematode) with an excellent safety profile, including no efficacy against non-targeted co-endemic species. We will benefit from collaborations with our industrial partners Bayer and Celgene providing preselected compounds to populate the early preclinical stages of the R&D pipeline. Compounds with the best profile will be progressed through preclinical studies. Corallopyronin A, a compound with proven efficacy against essential Wolbachia endosymbionts in filariae that has superiority to the gold standard doxycycline, excellent bioavailability and promising exploratory safety data will undergo state-of-the-art toxicity profiling to advance towards phase 1 trials. We will also evaluate oxfendazol and oxantel pamoate in clinical trials. They have already proven efficacious in animals or humans and will only require clinical trials according to current regulatory guidelines to be implemented. With this strategy, the consortium will ensure that a pipeline of drug candidates is available for treating onchocerciasis, especially should current candidates fail in upcoming clinical trials. Moreover, we will establish a much-needed drug R&D pipeline to treat soil-transmitted helminth infections for which there is currently neither a drug with good efficacy against all species nor any prospects on the horizon.

Keywords: soil transmitted helminthiasis,filariasis,onchocerciasis,nematode,corallopyronin a,oxantel pamoate,oxfendazol,drug development,phase 1 trial,preclinical
Beyond the Bamboo Hypothesis. A microscopic exploration of plant processing practices in prehistoric Palawan, Philippines, and their relationship to lithic technology. (BeBamb)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-12-01
End date: 2022-02-01
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The prehistory of SE Asia is very different from the rest of the Old World. The stone tool kit is rudimentary and production techniques lasted unchanged for millennia. Currently, the dominant hypothesis to explain it is the “Bamboo Hypothesis”: prehistoric hunter-gatherers would have adapted to their environment, the tropical forest and manufactured more complex implements in bamboo. The objective of this project is to explore the potential adaptation of Late Pleistocene hunter gatherers to the forest in Palawan, Philippines and its modalities: have stone tools really been used mostly to make bamboo tools? We know, thanks to plant remains discovered in the archaeological record, that several species were known and used. Therefore, we can hypothesise that the simplification of lithic technology could be due to a technological investment focusing on a large spectrum of plants and not only on bamboo. As objects made of plants do not preserve well, I will gather data by an indirect mean: studying use-wear and micro plant residues on stone tools. To increase the possibilities of diagnosis, I will move from classic qualitative use-wear analyses to a quantitative methodology using confocal microscopy. This method proved efficient to distinguish use-wear resulting from processing different plants in the Levant. This research will be conducted at the Institut Mila y Fontanals (CSCI), in Barcelona, where I will receive high level training in quantitative use-wear and at the Max Planck Institute for the Science of Human History (Jena, Germany) (secondment) where I will be trained in micro plant residue analyses. This project will contribute to our understanding of environmental influence on human development and the adaptability of our species to the rainforest. It will also question the assumption that simple technology is the reflection of simple society as lithic functional analyses may reveal a hidden complexity in plant related practices that may be unique to SE Asia.

Keywords: prehistory,rainforest,se asia,use wear,residues,stone tools,plants,bamboo
Collaboration of Humanities And Social Sciences in Europe (CHANSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: ERA-NET Cofund
Partnership: CHANSE (ERA-NET)
Countries involved: Estonia,Iceland,Austria,Spain,Germany,Norway,Bulgaria,Finland,Croatia,Hungary,Lithuania,Slovenia,Switzerland,Belgium,Romania,Slovakia,Sweden,Poland,Latvia,Czechia,Netherlands,Denmark,Luxembourg,United Kingdom
Call: Society and innovations: understanding the contexts, processes and consequences (H2020-SC6-TRANSFORMATIONS-2020, 2020)
Start date: 2021-01-01
End date: 2026-06-30
Duration (months): 66.0
Total project cost (EUR): 30303042.0
EU funding (EUR): 10000000.0
Participants: 30
Project status: SIGNED

CHANSE, Collaboration of Humanities and Social Sciences in Europe, is a joint initiative of 27 research funding organisations from 24 countries. The CHANSE Programme builds on the experience of two existing networks: HERA (Humanities in the European Research Area) and NORFACE (New Opportunities for Research Funding Agency Cooperation in Europe) supporting research in humanities and social sciences respectively. The main goal of the CHANSE inititive is to launch a transnational call for collaborative projects focused on the topic of Transformations: Social and cultural dynamics in the digital age. The objective of this call will be to help understand how digital innovations give rise to social and cultural changes, and are also influenced by society and culture. The joint research call combines the analytic and transformative powers of the humanities and social sciences in understanding processes of change and considering solutions when societies face the introduction of innovations. With a budget of over EUR 36 million, including expected EC co-funding, CHANSE consortium plans to fund excellent research projects conducted by research teams from at least three countries involved in the Programme. CHANSE will strive to produce a lasting effect on the research landscape by cultivating durable research collaboration across multiple national and regional borders, disciplinary boundaries, and stakeholders, thus supporting the sharing of excellence and promoting widening participation in the European Research Area. CHANSE will also strongly support knowledge exchange activities and foster relationships between academia and relevant stakeholders, as well as explore and develop new joint actions. By offering new opportunities for international research cooperation in a critical area of enquiry, the CHANSE Programme will deliver a broad range of academic, societal and economic impacts within, across and beyond the partner countries.

Keywords: digital transformations,digital innovations,social and cultural dynamics,digital age,co funded call,era net cofund
The Evolution and Function of Ancestral Brain States (reptiCode)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499563.0
EU funding (EUR): 1499563.0
Participants: 1
Project status: SIGNED

One of the oldest enigmas in neuroscience is the function of brain states. During these states, dramatic transitions occur in the firing patterns of neurons in the cerebral cortex. These transitions are correlated with behaviour during wakefulness but, strikingly, are even more prominent during sleep, when interaction with the environment is limited. The similarities between sleep and awake patterns remains unexplained, thus complicating our understanding of the global function of brain states. Additionally, state transitions are prominent in both the cortex and hippocampus, but the interplay between these areas during different states remains ambiguous. Why is the function of brain states so elusive? A likely explanation is that state transitions are inextricably intertwined with many other processes, rendering their dissection difficult. This project is motivated by the notion that to understand brain states we need to: a) examine them in a simpler model system, b) understand how they evolved, c) identify which state properties are fundamental and which are species specific. I suggest that studying brain states in the cerebral cortex of reptiles offers a unique opportunity for achieving all three goals. We will utilize the simpler and highly structured state organization in Pogona Vitticeps, to expose the full repertoire of brain states in a naturally behaving animal. We will take advantage of the limited diversity of motor movements in Pogona, to expose the link between population patterns and defined behaviors. We will furthermore exploit the unique evolutionary positions of reptiles as closest to stem amniotes, in which the layered cortex and hippocampus first emerged, to reveal the forces that pushed the emergence of brain states in evolution. Finally, through a comparative analysis of brain state properties between different lizards and mammals we will extract the fundamental properties and functions of brain states and the network that supports them.

Keywords: brain states,evolution,reptiles,pallium,sleep,sharp waves,reptile behavior,evolution of neural computation
Efficacy and safety of thrombectomy in stroke with extended lesion and extended time window: a randomized, controlled trial (TENSION)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Ireland,Germany,Germany,Switzerland,Belgium,Norway,Slovakia,Sweden,France,France,France,Czechia,Czechia,United States,Denmark
Call: Comparing the effectiveness of existing healthcare interventions in the adult population (H2020-SC1-2017-Two-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 5990684.5
EU funding (EUR): 5990684.5
Participants: 18
Project status: SIGNED

TENSION (efficacy and safety of ThrombEctomy iN Stroke with extended leSION and extended time window: a randomized, controlled trial) strives at providing innovative treatment to patients with severe stroke to reduce the individual and societal burden of death and dependency from stroke. To this end, TENSION is a randomized, controlled, prospective, open label, blinded endpoint (PROBE) trial of thrombectomy in stroke patients with extended ischemic stroke lesions and patients presenting in a late time window, who are currently excluded from available effective treatment approaches. The trial will enroll up to 665 subjects in eight European countries. The primary endpoint is functional outcome at 90 days post-stroke measured by the Modified Rankin Scale. The primary effectiveness endpoint analysis is a chi-square test of the difference in linear trends in ordinal mRS outcomes between treatment groups (“mRS shift analysis”). Outcome evaluation will involve a comprehensive array of clinical and safety parameters, health and socio-economic outcomes including patient reported outcome measures (PROM) for evaluation according to the principles of value-based healthcare. Health economic evaluation with cost-effectiveness analysis will be performed and gender-effects on treatment and outcome will be studied. Trial organization will rely on a network of experienced partners with successful cooperation in previous EU-funded stroke trials. An image core lab will provide central judgement of all images acquired within the trial. Standards of image judgement and intervention will be defined and trial specific training will be provided to all investigators. TENSION addresses a major health problem and will provide evidence for more effective and safer therapeutic intervention for patients with severe stroke resulting in improved guideline development, better individual patient outcomes and beneficial effects for the society at large by reduction of stroke-related costs.

Keywords: stroke,thrombectomy,endovascular treatment,extended lesion,time window,functional outcome,patient reported outcome measurement,value based healthcare