Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deep-Learning for Multimodal Sensor Fusion (DeeperSense)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Israel,Germany,Germany,Spain,Germany
Call: Research and Innovation boosting promising robotics applications (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2989238.75
EU funding (EUR): 2989238.75
Participants: 7
Project status: SIGNED

The main objective of DeeperSense is to significantly improve the capabilities for environment perception of service robots to improve their performance and reliability, achieve new functionality, and open up new applications for robotics. DeeperSense adopts a novel approach of using Artificial Intelligence and data-driven Machine Learning / DeepLearning to combine the capabilities of non-visual and visual sensors with the objective to improve their joint capability of environment perception beyond the capabilities of the individual sensors. As one of the most challenging application areas for robot operation and environment perception, DeeperSense chooses underwater robotics as a domain to demonstrate and verify this approach. The project implements DeepLearning solutions for three use cases that were selected for their societal relevance and are driven by concrete end-user and market needs. During the project, comprehensive training data are generated. The algorithms are trained on these data and verified both in the lab and in extensive field trials. The trained algorithms are optimized to run on the on-board hardware of underwater vehicles, thus enabling real-time execution in support of the autonomous robot behaviour. Both the algorithms and the data will be made publicly available through online repositories embedded in European research infrastructures. The DeeperSense consortium consists of renowned experts in robotics and marine robotics, artificial

Keywords: marine robotics,deep learning
Procedural Tools for Effective Governance (PROTEGO) Patterns, Outcomes and Policy Design Procedural Tools for Effective Growth: Patterns, Outcomes and policy Design (PROTEGO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy,Italy,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1792778.0
EU funding (EUR): 165030.99
Participants: 4
Project status: CLOSED

PROTEGO arises out of a fundamental claim: procedural regulatory instruments have causal effects on the performance of political systems because they trigger accountability towards different stakeholders. The mix of policy instruments may be functional or dysfunctional, depending on how accountability mechanisms are combined. This project provides a theoretical rationale to capture the accountability effects by adopting an extension of delegation theory that considers multiple stakeholders. The theoretical framework will allow us to identify the key social mechanisms that make bureaucracies internalize the preferences of accountees. We will test the observable implications of the framework on outcomes that are crucial to the performance of political systems, such as trust in government, ease of business, control of corruption, sustainability. Empirically, we will collect, validate and analyze original data across the EU and its 28 Member States for the period 2000-2015, distinguishing between instruments that cover central departmental activity and independent regulatory agencies. The new dataset will cover administrative procedure acts, freedom of information, notice and comment, judicial review, impact assessment, environmental appraisal, and non-financial instruments for public spending accountability. These are the procedural instruments that enfranchise accountees. The bivariate relationship between a single instrument and outcomes explains little – because it’s the overall ecology or mix of instruments that produces causal effects. These ecologies combine in different sequences and paths associated with the outcome. Hence we will draw on a suitable methodological approach - Qualitative Comparative Analysis (QCA). Causality and diffusion across time will be also explored via event-history analysis and principal component analysis. PROTEGO will contribute to theories of regulation and accountability, and provide a robust operational model of data and analysis.

Keywords: policy instruments,public administration,regulation
CompLex thErmoAcoustic iNteraction mEchanisms in spRay Flames in Low-nox Annular coMbustion chambErS (CLEANERFLAMES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-16
End date: 2021-09-15
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

This project is focused on the fundamental problem of combustion dynamics that has many practical implications. It specifically considers annular systems like those used in land based gas turbines and aeroengines. The corresponding combustors feature new architectures that reduce pollutant NOx emissions to comply with increasingly stringent regulations. However, these new designs and the essentially lean premixed mode they employ also promote a resonant coupling between combustion and acoustic modes. These combustion instabilities have many detrimental effects leading in extreme cases to mechanical failure. Despite the large number of investigations concerning instabilities arising with premixed flames yet few are the studies dealing with cases where the fuel is injected as a spray. Furthermore, the limited availability of engine data is a further obstacle for these studies in a real combustor. The present project aims to fill this gap of knowledge by proposing combined numerical and experimental investigations on spray flame dynamics and spray flame coupling with azimuthal modes in annular systems. The project first focuses on the analysis of the nonlinear response of a single spray flame to incoming acoustic perturbations via Large Eddy Simulations. The study is then extended to a multiple swirl spray injector injector system to investigate the impact on the flame response of the interaction between multiple adjacent flames. Numerical results are compared with experiments carried out in unique facilities available at EM2C Laboratory including the annular MICCA-Spray combustor. Theoretical and numerical procedures involving advanced coupling of the combustor acoustics with the obtained flame responses are developed to predict the limit cycles observed during experiments. Finally, the combustion dynamics observed experimentally in a Safran Aircraft Engine combustor will be investigated to verify the transferability of the developed techniques to a full-scale system.

Keywords: thermoacoustic instabilities,spray flame,flame describing function,flame to flame interactions,annular combustor,large eddy simulations
How does climate warming duration affect above- and belowground plant traits and overall tundra ecosystem functionality? (WarmTraits)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-05-01
End date: 2023-09-03
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

Climate warming is changing vegetation across the Arctic tundra region. Warmer temperatures enhance plant photosynthetic uptake of atmospheric CO2 but warming also promotes microbial decomposition of the vast permafrost carbon pool, releasing greenhouse gases to the atmosphere in a positive feedback-loop. In addition to temperature, changes in plant composition also strongly affect carbon and nutrient cycling rates through species-specific differences in leaf and root characteristics. These so-called plant functional traits provide an essential link between vegetation change and ecosystem functionality, and understanding how climate warming affects tundra plant traits is therefore vital for accurately forecasting ecosystem impacts over the coming century. Climate-change manipulation experiments allow for process-based investigations into how ecosystems respond mechanistically to warming. However, lack of long-term experimental warming studies in the Arctic currently impedes our ability to predict future climate responses accurately over decadal time-scales because extrapolation of short-term data consistently leads to faulty long-term predictions. In WarmTraits, I will utilize a unique opportunity to destructively sample in a long-term experiment where greenhouses have warmed tundra plots for one, 11, and 21 years, respectively. Thereby, I will quantify the mechanistic effects of increasing climate-warming duration on a very comprehensive suite of above- and belowground plant functional traits. In addition, I will directly link functional trait changes to ecosystem functionality by measuring important ecosystem carbon and nitrogen cycling processes using stable isotope labelling. I have the required expertise in ecosystem ecology and biogeochemistry to implement the project objectives successfully, and my host’s expert knowledge ensures that I will receive top-tier research training in plant physiology and stable isotope techniques.

Keywords: functional traits,stable isotopes,ecosystem function,carbon cycling,experimental manipulation,warming,above and belowground interactions
Translation of adaptive optical microscopy expertise to the commercial domain (AdOptEx)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Adaptive optics (AO) is an important technology for high-resolution microscopy that overcomes imaging problems when focusing inside biological specimens. Through the ERC Advanced Grant AdOMiS we have developed and experimentally validated new, broadly applicable AO tools that make integration of this technology more practical for a range of different microscopy techniques. We have also accumulated significant know-how about effective implementation of this technology. The challenge now is to translate these laboratory-based methods and know-how outside the academic research environment. This project will facilitate access to the products of our research to potential research and commercial adopters so that they can successfully deploy our AO methods in their systems.

Keywords: optical microscopes,adaptive optics
How does the ubiquitin-like protein NEDD8 activate ubiquitin ligase machineries? (Nedd8Activate)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 2193871.0
EU funding (EUR): 2193871.0
Participants: 1
Project status: SIGNED

Post-translational modification by ubiquitin and ubiquitin-like proteins (UBLs) is a major eukaryotic regulatory mechanism. Nonetheless, we have little understanding of the detailed mechanisms by which most E3 ligases mark specific targets with monoubiquitin, multiple ubiquitins or specific polyubiquitin chains, or of how UBL modifications transform the functions of their targets. This proposal addresses both problems. First, we will discover the structural mechanisms by which the UBL NEDD8 (58% identical to ubiquitin) activates numerous distinct functions of its targets, which are cullin subunits of cullin-RING E3 ubiquitin ligases (CRLs). Second, we will take a tour-de-force structural, biochemical, and molecular cell biological approach to determine how NEDD8-activated E3 ligases regulate their substrates. Because CRLs form nearly half of all E3 ligases, and as we recently discovered, neddylated CRLs act in part by activating monoubiquitylation by another family of E3 ligases (Ariadne-family RBR E3s), the proposed studies will establish paradigms for a major fraction of ubiquitylating enzymes. To achieve these goals, we will devise novel chemical biology tools to capture fleeting assemblies that typically only occur during chemical reactions, and visualize structures of neddylated CRLs “in action” by cryo EM. We will generate a resource of novel reagents that detect, label, and affinity purify activated forms of E3 ligases to temporally track their interactions during pathways they regulate in cells. And we will define the mechanisms and structures of a class of atypical, disease-associated giant E3 ligases whose domains and interacting partners are so peculiar that their activities remain elusive. Overall, we will comprehensively define how a UBL directly regulates its targets, and how two major E3 ligase families mediate regulation.

Keywords: ubiquitin,nedd8,e3 ligase,cullin ring
Uncharted Anti-Radicalism Strategies: Challenging the Interpretative and Hermeneutical Methodologies of the Salafi-Jihadi Theology (SJMethod)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

Killing of civilians, death penalty, enslavement, or gender discrimination are common Salafi-Jihadi practices. The emergence of the Salafi-Jihadi theology embodied by groups such as affiliates Al Qaeda, Boko Haram, IS, is the result not only of a complex socio-political context, but also of a recent epistemological crisis that affected Muslim countries. Existing research focusing on explaining and preventing the phenomenon of Islamic radicalization has paid scant attention on the hermeneutical methodologies and epistemological paradigms that make possible the Salafi-Jihadi vision. The proposed research addresses this gap. The overarching novel research aim is to demonstrate the impact of the S-J interpretative and hermeneutical methodology on the construction of the violent S-J theology. Three main research objectives are proposed: 1) to make a critical comparative analysis between the premodern, modern, and contemporary hermeneutical methodologies applied to the Qur’an; 2) to construct the interpretative and hermeneutical methodological profile of the S-J theology; 3) to assess the socio-cultural impact of the premodern, progressive, and especially S-J hermeneutical methodologies, with a focus on gender egalitarianism, religious pluralism, and Muslims integration in Western societies. This innovative, interdisciplinary project will operate with Qur'anic exegetical, hermeneutical, and epistemological studies, gender and masculinities studies, sociotheology, feminist theology, social sciences empirical studies, and Jihadist studies. The research will give more visibility to progressive Islamic interpretations that challenge the dichotomies between Islam-Western culture, tradition-modernity, promoting a common, human-rights based axiological language, goals, and practices. Project findings will be disseminated to crucial target audiences through peer-reviewed journal articles, conference presentations, workshops and an educator’s handbook.

Keywords: salafi jihadi theology,salafism,jihadism,qur anic exegesis,qur anic hermeneutics,qur anic epistemology,gender,prevention of radicalization,islamic extremism,progressive muslim thought
COsts and Mechanisms of Personalised Exercise and Education for chronic Low back pain (COMPEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-08
End date: 2021-01-07
Duration (months): 36.0
Total project cost (EUR): 254313.0
EU funding (EUR): 254313.0
Participants: 2
Project status: CLOSED

Back pain is the leading cause of disability in Europe. Chronic low back pain (CLBP) is the most costly and burdensome form. As the EU population ages, there is an urgent need for more clinically and cost-effective therapies to ensure sustainable healthcare. Dr O’Keeffe will explore a personalised medicine approach to exercise and education for CLBP. This is cutting edge, and has shown promising results beyond other therapies. Dr O’Keeffe is the perfect match for this project, as she has led a trial on this novel therapy for her PhD. This will be the first project to examine the mechanisms, response, and the cost-effectiveness of personalised exercise and education for CLBP. This will build on Dr O’Keeffe’s experience to expand and develop her skills in this area. Dr O’Keeffe will be trained in mediation, moderation and economic evaluation. She will gain additional research skills in new study designs, research software, physical activity measurement, gender analysis and public patient involvement. She will gain transferable skills in communication and public engagement, interdisciplinary networking, grantsmanship, project management, leadership and supervision. She will gain exposure to the non-academic sector through a secondment to a non-governmental organisation. Dr O’Keeffe will disseminate her results through open-access journals and conferences. She will communicate her results and Marie Sklodowska-Curie experience through social media, TV, radio and European Research events. If awarded this fellowship, Dr O’Keeffe will be equipped with the right skillset to improve her employability and reach a position of professional maturity. She will expand the European Research Area by strengthening networks. She will put Europe at the forefront of excellence and innovation for CLBP by promoting a safe exercise and education therapy for EU citizens. This will allow billions of euro that the EU currently spends on CLBP to be redirected to other health care services.

Keywords: chronic low back pain,exercise,clinical trial,education,treatment mechanisms,costs
Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia (TREATMENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Israel,Spain,Ireland,Slovenia,Sweden,Portugal,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 3750898.68
EU funding (EUR): 3750898.6799999997
Participants: 12
Project status: CLOSED

TREATMENT is a Marie Sklodowska Curie Innovative Training Network proposal directly addressing the need for high-level training and career paths in risk evaluation of drug induced metabolic dysfunctions, a relevant aspect, so far unexplored by traditional toxicology studies, but urgently needed to challenge current severe limitations of health care interventions in mental disorders. These patients require life-long medications that subsequently trigger metabolic diseases with a strong negative impact on their health and well-being. To achieve this, and improve adherence to treatments, we will evaluate how short-term antipsychotic drug responses impact long-term metabolic control to identify and validate biomarkers with clinically predictive value for targeting drug induced metabolic dysfunctions. This effort will have added commercial value by enabling the design of predictive marker kits for testing adverse secondary metabolic effects of drugs to be used in pharmacological and medical practice. TREATMENT will provide multidisciplinary knowledge, capabilities and tools to implement this ambitious strategy by the training of young scientists in a program that combines pharmacology, metabolism and mental health research with strategies for product and tool design and validation. Our ultimate goal is to empower the intersectorial and trans-national employability of young scientists across academic, public and private sectors to foster the development and implementation of personalized medicine tools that will provide effective treatment regimens for life long health-care interventions and decrease the risk for development of chronic metabolic diseases.

Keywords: metabolism,adverse side effects,schizophrenia,life long treatment,personalized medicine,healthy aging,training,network,open science,horizon 2020