Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Objectively Measuring MS Fatigue (MS Fatigue_Therapy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-15
End date: 2018-05-14
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Multiple Sclerosis (MS) is the most common debilitating disease in young adults worldwide. Diagnosed in over 2.3 million people, this neuro-immunological disease is most prevalent in Europe and North America, with over 120,000 diagnosed cases in Germany alone. Great strides have been made in developing medications that slow disease progression, however, the daily symptomatology of MS remains largely untreated. This research proposes investigations of (1) an instrument for objectively measuring MS fatigue and (2) a therapeutic methodology for MS fatigue and disability. Despite great individual variation in MS symptomatology, “MS fatigue” verges on characteristic, reported by 80% of patients. However, there is currently no standardized means of evaluating or treating MS fatigue. Movement Behavior Analysis and Scales Test (i.e., BAST) tests and pre- and post-test vital signs of 40 persons with MS will be compared to that of 40 neurotypical matched controls. If the BAST is shown to reliably measure MS fatigue, then a testing and rating system for large-scale clinical use will be developed. To test the ability of the BAST to measure changes in MS fatigue and categorize physical disability, a long-term controlled study of the impact of hippotherapy (i.e., therapeutic horseback riding) will be undertaken in 24 individuals with MS. The standardized BAST will afford a robust analysis of movement ability and disability, enabling measurement of symptoms including gait, balance, spasticity, and fatigue. To achieve project objectives while facilitating ample mentorship, this project brings together the movement research facilities and faculty of the German Sport University Cologne (including mentor Dr. Hedda Lausberg, creator of the BAST), researchers and hippotherapists at the Gold-Kraemer Foundation Center for Physical Activity and Sport, and an internship at the University of Cologne Department of Neurology and Center for Palliative Medicine.
Synthetic Lives: The Futures of Mining (SYNTHLIVES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The global extractive industry is undergoing three critical transformations: first, the advent of synthetic or lab-grown minerals, impacting the mining industry and the extraction of resources from nature; second, the creation of fully automated mining operations, seeking to render human work redundant or accessory to that of bots, drones, and other autonomous machines; third, the introduction of digital data and disintermediation technologies for mining management and traceability. Taken together, these innovations anticipate a future of mining that replaces nature with synthetic substances, human labor with intelligent machines, and intermediaries with unmediated accountability. This project responds to these changing conditions with a novel conceptualization of the emergent relationship entangling synthetic and natural objects, humans and machines, material and digital spaces: Synthetic Lives. It asks: What is the role of humans and non-human nature in increasingly synthetic, automated, and digital mining economies? This research innovates by bringing together three related areas of scholarly enquiry: i) resource materialities, to destabilize the divide between nature and culture; ii) mediation and technology, to problematize the separation between humans and machines; iii) algorithmic governance and digital transparency in mining sites, to untangle how material and digital properties are co-produced. Through a multi-sited and multi-methods study, it contributes to these fields of research in three case studies: synthetic laboratories, automated mines, and digital and data-driven mining processes. Interlacing these three foci, Synthetic Lives assists policy-making on environmental, employment, and social-digital issues, and inaugurates a debate of anthropological import: What are the political, epistemological, ecological, and economic consequences of a future that promises to be entangled in synthetic properties, autonomous machines, and digital technologies?

Keywords: mining,automation,synthetic,extraction,digital,futures,nature
Tobacco cessation within TB programmes: A ‘real world’ solution for countries with dual burden of disease (TB and Tobacco)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Czechia,Bangladesh,United Kingdom,United Kingdom,Nepal,Pakistan,United Kingdom
Call: Global Alliance for Chronic Diseases. Prevention and treatment of lung diseases (H2020-HCO-2015, 2015)
Start date: 2015-11-01
End date: 2019-10-31
Duration (months): 48.0
Total project cost (EUR): 2999828.75
EU funding (EUR): 2999828.75
Participants: 10
Project status: CLOSED

We aim to reduce the burden of tobacco-related lung diseases. Our approach is to integrate inexpensive tobacco cessation strategies of proven efficacy into TB control programmes. This has three advantages: a) Preventing non-communicable diseases as well as reducing TB-related deaths; b) TB patients are more likely to quit tobacco than healthy smokers – ‘teachable moments’; and c) in the absence of specialist infrastructure, an approach to ‘piggyback’ cessation on existing programmes is a desirable policy imperative. We will first assess the effectiveness and cost-effectiveness of tobacco cessation strategies in helping TB patients to quit and improving their TB outcomes - the effectiveness goal; and then explore how best these strategies can be delivered, sustained and scaled-up – the implementation goal. We propose six work packages for Bangladesh, Nepal and Pakistan - high TB and tobacco burden countries. WP1 Development & Feasibility: To optimise the delivery of tobacco cessation strategies within TB programmes (focus group discussions [FGD], interviews, surveys, expert panel workshops) WP2 & 3 Effect and economic evaluation: To assess the effectiveness and cost effectiveness of cytisine with behavioural support vs. behavioural support alone on tobacco cessation and TB outcomes (randomised controlled trial [RCT]) WP4 Process evaluation: To study the design and delivery of the tobacco cessation strategies (FGD, observations, exit interviews) WP5 Context evaluation: To study the influence of contextual factors on the RCT outcomes (lit. review, interviews, surveys, analysis) WP6 Scale up & Sustainability: To assess sustainability of the cessation strategies and identify the likely costs, obstacles and opportunities for scaling these up (FGD, interviews, cost and outcomes analysis) Our ambition is that by studying the ‘real world’ influences on the implementation and success of tobacco cessation we will be able to translate our findings into benefits for patients

Keywords: tobacco,smoking,cigarettes,tuberculosis,cessation,behavioural support,cytisine,randomised controlled trial,integration,low and middle income countries
Fuel INjector Coking and Autoxidation Prediction (FINCAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom
Call: Fuel injector coking (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-05-01
End date: 2021-08-31
Duration (months): 52.0
Total project cost (EUR): 999981.25
EU funding (EUR): 999981.25
Participants: 1
Project status: CLOSED

The aim of this project is to develop a robust theoretical framework to allow the modelling of the build-up of surface carbonaceous deposits in jet fuel injection systems so that fuel injectors for advanced engines such as the VHBR may be designed with an acceptable maintenance frequency and their life span predicted. Given the high heat sink requirement on aviation fuel in geared turbofan architecture, the prediction capability developed within this proposal is essential to a rapid and low cost development of VHBR, lean burn fuel injector systems. The project team consisting of the Low Carbon Combustion Centre, the Department of Chemistry and the Centre for Advanced Manufacturing in the University of Sheffield will conduct a three-year programme to develop the understanding of fuel injector coking through a combination of experimentation and simulations of various scales and complexities. The proposed programme builds on the significant expertise within the core team. The objectives of the Proposal are: 1. Construction of an updated and robust autoxidation kinetic mechanism for surrogate hydrocarbons representative of an approved aviation fuel. 2. Validation of the detailed mechanism with autoxidation results for real fuel and surrogate hydrocarbon obtained in a near isothermal plug flow reactor over a range of temperatures. Followed by the automated mechanism reduction through species lumping and reaction grouping. 3. Validation of mathematical model with respect to the experimental results obtained from low TRL level experiments and parameter optimisation 4. Experimental investigation of surface deposition in a simulated burner feed arm using “Aviation Fuel Thermal Stability Test Unit” and assess impact of surface roughness in a representative fuel injector at TRL 5 conditions to validate coking model. 5. Incorporate this understanding into a number of modelling tools to permit incorporation of coking calculations within CFD packages.

Keywords: aviation fuel,aerospace,coking,modelling,simulation,efficiency,cost effectiveness
Precision Gravity: From the LHC to LISA (LHCtoLISA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2024-11-30
Duration (months): 66.0
Total project cost (EUR): 1975000.0
EU funding (EUR): 1975000.0
Participants: 1
Project status: SIGNED

The nascent field of gravitational wave (GW) science will be an interdisciplinary subject, enriching different branches of physics, yet the associated computational challenges are enormous. Faithful theoretical templates are a compulsory ingredient for successful data analysis and reliable physical interpretation of the signals. This is critical, for instance, to study the equation of state of neutron stars, the nature of black holes, and binary formation channels. However, while current templates for compact binary sources may be sufficient for detection and crude parameter estimation, they are too coarse for precision physics with GW data. We then find ourselves in a situation in which, for key processes within empirical reach, theoretical uncertainties may dominate. To move forward, profiting the most from GW observations, more accurate waveforms will be needed. I have played a pioneering role in the development and implementation of a new formalism, known as the ‘effective field theory approach’, which has been instrumental for the construction of the state-of-the-art GW template bank. The goal of my proposal is thus to redefine the frontiers of analytic understanding in gravity through the effective field theory framework. Even more ambitiously, to go beyond the current computational paradigm with powerful tools which have been crucial for `new-physics' searches at the Large Hadron Collider. The impact of the high-accuracy calculations I propose to undertake will be immense: from probes of dynamical spacetime and strongly interacting matter, to the potential to discover exotic compact objects and ultra-light particles in nature. Furthermore, GW observations scan gravity in a regime which is otherwise unexplored. Consequently, the coming decade will tell whether Einstein's theory withstands precision scrutiny. In summary, my program will provide novel techniques and key results that will enable foundational investigations in physics through GW precision data.

Keywords: post newtonian theory,effective field theory,gravitational waves
Degradable commodity plastics from metallosupramolecular polymers (DECOMPOSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-15
End date: 2022-06-14
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

The need for more sustainable and environmentally-friendly products and materials is driven by an increasing environmental and health awareness, opening new markets with significant economic potential. Specifically, plastic and microplastic pollution are parts of an environmental hazard which have received significant media attention over the last few years. The difficulty in recycling commodity plastics means that incineration and landfills are the predominant ways of dealing with this waste. Novel materials are necessary to tackle these issues and facilitate the recycling and degradation of (commodity) polymers. Building on the expertise of the host supervisor (Prof. Christoph Weder) and his group at the Adolphe Merkle Institute, University of Fribourg, in the field of supramolecular polymers and material science, novel materials based on metallosupramolecular polymers will be developed which are envisaged to provide a solution to the above issues. Moreover, a novel platform for metallosupramolecular polymers based on renewable building blocks will be developed which allow to prepare bio-based, benign, and (bio)degradable metallosupramolecular polymer precursors. This MSCA will provide the applicant with the unique opportunity to improve his scientific skill set and network in the scientific community and allow the applicant to apply for independent academic positions in the polymer and material science field by the end of this fellowship.
Precision Docking of Very Large DNA Cargos in Mammalian Genomes (DNA-DOCK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-08-31
Duration (months): 72.0
Total project cost (EUR): 2498578.0
EU funding (EUR): 2498578.0
Participants: 1
Project status: SIGNED

Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions. To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date. We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accelerate T cell engineering, resolving unmet needs. Once we accomplish our tasks, our technology has the potential to be exceptionally rewarding to the scientific, industrial and medical communities.

Keywords: genome engineering,gene editing,dna delivery,minimal genome,synthetic dna circuits,transduction,epitoping,dsdna break repair,nhej,t cell engineering,nanobody,ribosome display
Towards Industrial LES/DNS in Aeronautics – Paving the Way for Future Accurate CFD (TILDA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Belgium,Russian Federation,Belgium,Belgium,France,France,France,United Kingdom
Call: Competitiveness of European Aviation through cost efficiency and innovation (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-12-31
Duration (months): 44.0
Total project cost (EUR): 3048742.5
EU funding (EUR): 2706241.75
Participants: 11
Project status: CLOSED

The ability to simulate aerodynamic flows using CFD methods has progressed rapidly over the last decades and has given rise to a change in design processes in aeronautics already. But more improvement is necessary to overcome the (still) existing lack in confidence in CFD usage, based on turbulence modelling. The TILDA project will offer methods and approaches combining advanced and efficient high-order numerical schemes (HOMs) with innovative approaches for LES and DNS in order to resolve all relevant flow features on tens of thousands of processors in order to get close to a full LES/DNS solution for 1billion degrees-of-freedom (DOF) not exceeding turn-around times of a few days. The TILDA project will provide both an improved physical knowledge and more accurate predictions of non-linear, unsteady flows – near borders of the flight envelope - which will directly contribute to an enhanced reliability. The main highly innovative objectives, targeting at industrial needs read: • Advance methods to accelerate HOM for unsteady turbulence simulations on unstructured grids. • Advance methods to accelerate LES and future DNS methodology by multilevel, adaptive, fractal and similar approaches on unstructured grids. • Use existent large scale HPC networks to enable industrial applications of LES/DNS close(r) to daily practice. Compact high-order methods offer a very high ratio between computational work per DOF combined to a low data dependency stencil, making these methods extremely well adapted for shared-memory parallel processors, and allow for efficient redistribution over an increased number of processors. • Provide grid generation methods for HOM on unstructured grids with emphasis on valid curvilinear meshes for complex geometries, and accounting for mesh and solution quality. • Provide suitable I/O and interactive co- and post-processing tools for large datasets. • Demonstration of multi-disciplinary capabilities of HOM for LES in the area of aero-acoustics.

Keywords: large eddy simulations,direct numerical simulations,high order methods,high performance computing
Programmable ARTificial immune systems to fight cancer (ARTimmune)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

Immunotherapy has entered centre stage as a novel treatment modality for cancer. Notwithstanding this major step forward, toxicity and immunosuppression remain major obstacles, and illustrate the pressing need for more powerful and specific immunotherapies against cancer. To overcome these roadblocks, in ARTimmune, I propose to follow a radically different approach by developing local rather than systemic immunotherapies. Taking advantage of the architecture of a lymph node (LN), I aim to design fully synthetic immune niches to locally instruct immune cell function. I hypothesize that programmable synthetic immune niches, when injected next to a tumour, will act as local powerhouses to generate bursts of cytotoxic T cells for tumour destruction, without toxic side effects. Single cell transcriptomics on LN, obtained from patients that are vaccinated against cancer, will provide unique insight in communication within immune cell clusters and provide a blueprint for the intelligent design of synthetic immune niches. Chemical tools will be used to build branched polymeric structures decorated with immunomodulating molecules to mimic LN architecture. These will be injected, mixed with sponge-like scaffolds to provide porosity needed for immune cell infiltration. Programming of immune cell function will be accomplished by in vivo targeting- and proteolytic activation- of immunomodulators for fine-tuning, and to extend the life span of these local powerhouses. The innovative character of ARTimmune comes from: 1) novel fundamental immunological insight in complex communication within LN cell clusters, 2) a revolutionary new approach in immunotherapy, by the development of 3) injectable- and 4) programmable- synthetic immune niches by state-of-the-art chemical technology. When successful, it will revolutionize cancer immunotherapy, moving from maximal tolerable dose systemic treatment with significant toxicity to local low dose treatment in the direct vicinity of a tumour

Keywords: cancer immunotherapy,chemical engineering,artificial immune sytem,single cell,transcriptomics,3d polymer scaffolds