Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovation in personalised Nutrition through Cluster cooperation in the Silver economy (INCluSilver)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Innovation actions
Countries involved: Spain,Ireland,Italy,Greece,Hungary,Sweden,France,United Kingdom,Denmark
Call: Cluster facilitated projects for new industrial value chains (H2020-INNOSUP-01-2016-twoStage, 2016)
Start date: 2017-03-01
End date: 2020-02-29
Duration (months): 36.0
Total project cost (EUR): 4115114.4
EU funding (EUR): 4115114.3
Participants: 10
Project status: CLOSED

On one hand, personalised nutrition - PN offers a new approach for helping citizens to adjust their dietary behaviour by advising food choices and eating patterns that fit their individual needs and are in line with personal preferences. On the other hand, the Silver Economy is driven both by the emergence of new consumer markets and by the need to improve the sustainability of public expenditure linked to ageing. Thus, stimulating the market of PN products and services addressing the needs of the silver society can create a massive pull-effect on existing or emerging markets, as well as a huge impact on Health Care systems. INCluSilver project aims at supporting the collaboration between actors belonging to different sectors in order to create the right conditions for generating and validating innovative ideas in the field of PN for the silver population that have a great potential to reach the market. The collaboration will favour the leveraging of the Personalised Nutrition Value Chain which have healthy nutrition of the European silver society as common ground in the framework of this project. Furthermore, a Personalised Nutrition for the Silver Economy - PNSE Strategy will be pursued within this project and aligned with the smart specialisation strategies. To achieve this, the INCluSilver consortium has assembled 7 clusters and 2 universities from 9 countries and 4 different sectors: agro-food, ICT, health and creative industries . The project thus has direct access to a network of more than 900 SMEs related to PN topics and challenges, identified in this proposal. INCluSilver workplan is organised in six interrelated workpackages that will assure the active participation of all partners. All outcomes will be disseminated broadly by direct engagement with a wide audience(end-users, healthcare professionals, researchers, food producers, technology providers, policy makers) via different networks, events, web, newsletters, social media and newspapers.

Keywords: personalised nutrition,silver economy,smart specalization strategies,innovation voucher scheme,open innovation platform
Imaging Perfusion Restrictions from Extracellular Solid Stress (ImPRESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Norway
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-03-31
Duration (months): 63.0
Total project cost (EUR): 1499638.0
EU funding (EUR): 1499638.0
Participants: 1
Project status: CLOSED

Even the perfect cancer drug must reach its target to have an effect. The ImPRESS project main objective is to develop a novel imaging paradigm coined Restricted Perfusion Imaging (RPI) to reveal - for the first time in humans - vascular restrictions in solid cancers caused by mechanical solid stress, and use RPI to demonstrate that alleviating this force will repair the cancerous microenvironment and improve therapeutic response. Delivery of anti-cancer drugs to the tumor is critically dependent on a functional vascular bed. Developing biomarkers that can measure how mechanical forces in a solid tumor impair perfusion and promotes therapy resistance is essential for treatment of disease. The ImPRESS project is based on the following observations; (I) pre-clinical work suggests that therapies targeting the tumor microenvironment and extracellular matrix may enhance drug delivery by decompressing tumor vessels; (II) results from animal models may not be transferable because compressive forces in human tumors in vivo can be many times higher; and (III) there are no available imaging technologies for medical diagnostics of solid stress in human cancers. Using RPI, ImPRESS will conduct a comprehensive series of innovative studies in brain cancer patients to answer three key questions: (Q1) Can we image vascular restrictions in human cancers and map how the vasculature changes with tumor growth or treatment? (Q2) Can we use medical engineering to image solid stress in vivo? (Q3) Can RPI show that matrix-depleting drugs improve patient response to conventional chemo- and radiation therapy as well as new targeted therapies? The ImPRESS project holds a unique position to answer these questions by our unrivaled experience with advanced imaging of cancer patients. With successful delivery, ImPRESS will have a direct impact on patient treatment and establish an imaging paradigm that will pave the way for new scientific knowledge on how to revitalize cancer therapies.

Keywords: magnetic resonance imaging,longitudinal radiographic monitoring,treatment resistance,human brain cancers,clinical diagnostics of physical forces and impaired vasculature,image guided surgery
Effects of Structural Change on Income Inequality (STRCHANGEINEQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Türkiye,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 157734.0
EU funding (EUR): 157734.0
Participants: 2
Project status: CLOSED

This project aims to identify the distributional effects of the structural change phenomenon. It develops a dynamic macroeconomic model that introduces heterogeneities across workers and asset owners into the structural change models. For this purpose, it will focus on growth models with heterogeneous agents and complete asset markets. With this methodology, we will be able to characterize not only the aggregate patterns of structural change, but also its distributional consequences. By uncovering the long term factors behind the evolution of income distribution during structural change, the proposed model will be highly relevant to the most recent debates of rising income inequality in developed countries. The theoretical model will be calibrated to assess and quantify the historical roots of the current distributional picture in U.S. and Europe. In doing so, it will determine the “structural” level of inequality; a level that is due to the intrinsic forces of structural change. Then any deviations -positive or negative- from this level can be identified as “political”, which would provide a clearer picture of the effects of governmental policies on inequality. This model will be the first in the literature to integrate structural models with distributional issues and will open up a new research area. Finally, the model will be enriched with fiscal policies such as income taxes and productive government spending in order to draw policy conclusions regarding the growth-income inequality relationship in Europe, where boosting economic growth while holding the income inequality at a socially acceptable level has been a major concern in recent years. Therefore, the proposed project will both contribute to advancement of European research and address one of the Societal Challenges targeted by H2020 programs, which is working towards “Inclusive, innovative and reflective societies”.

Keywords: structural change,economic growth,income distribution,heterogeneous agent models
Expressivism and Normative Realism (ENR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Normative realism is the view that there are objective normative facts, i.e. facts about what is good, right, or rational, and many of our beliefs about these facts are true. Expressivism about normative discourse is the view that normative claims express desire-like mental states, such as attitudes of approval and disapproval, rather than ordinary beliefs. These two perspectives on normativity are in tension, yet each seems to capture something essential about normative thought: realism makes good on intuitions about truth and objectivity that seem non-negotiable from the engaged perspective of a deliberating agent, while expressivism accounts for the motivational force of normative thought and for the possibility of radical disagreement on normative matters. This project aims to reconcile normative realism and expressivism about normative discourse via three research objectives: (1) arguing that all forms of expressivism (i.e., semantic, pragmatic, meta-semantic) can be made compatible with realism; (2) defending a meta-semantic version of expressivism by isolating its philosophical benefits; (3) showing that not only is expressivism compatible with a commitment to objective normative truths, but it needs to be combined with such a commitment in order to fully account for normative disagreement. Each research objective will yield one stand-alone paper, and together they will result in a book proposal. These deliverables will help re-integrate the ER into the European philosophical community and establish him as one of the leading European experts in metaethics.

Keywords: expressivism,normative realism,minimalism,objectivity,disagreement
Transforming Growth Factor – Bench To Bedside. Towards a better understanding of TGF-β isoform specific signalling in health and disease (TGF-BTB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2023-07-31
Duration (months): 36.0
Total project cost (EUR): 271732.8
EU funding (EUR): 271732.8
Participants: 2
Project status: SIGNED

TGF-BTB (Transforming Growth Factor – Bench To Bedside) is an ambitious and innovative project, the goal of which is to not only to understand the different roles of the TGF-β isoforms as well as in cell signalling at a molecular level, but also to explore their critical roles implicated in pathogenesis of fibrotic disorders and cancer. The dysregulation or complete shutdown of TGF-β pathway is responsible for many human diseases including connective tissue disorders, fibrotic disorders and the initiation and progression of soft tissue cancers. Most recent data show the importance of TGF-β in controlling the tumor microenvironment and its significance in the course of anticancer immunotherapies. The project will employ methods of structural and cell biology, together with in silico simulations, and will include the development of new tools, such as isoform-specific peptide-based inhibitors, engineered cytokines to study and manipulate the TGF-β canonical and non-canonical pathways. TGF-BTB is not only of great importance for increasing basic mechanistic understanding of TGF-β signalling, but also in terms of discovering potential new therapeutic avenues for treating diseases driven by excessive TGF-b signaling. During the outgoing phase, The Fellow, Dr Łukasz Wieteska, will join Prof Andrew Hinck’s research group at the University of Pittsburgh, which is a world class research laboratory at the forefront of TGF-β family structural studies. the Fellow will return to the University of Leeds to continue his work with Prof John Ladbury, whose research has a strong focus on exploring the structural, biophysical, and cellular outcomes of the interplay of protein receptors in cell signalling pathways. Upon return, the Fellow will also benefit from a secondment at The Francis Crick Institute in the laboratory of Dr Caroline Hill, a leading researcher in the field of developmental biology with a special focus on TGF-β signaling.

Keywords: tgf,betaglycan,signaling,peptide based inhibitors
Colorimetric Precision Nanodiagnostics made Fast and Affordable (Nano4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-07-01
End date: 2021-12-31
Duration (months): 42.0
Total project cost (EUR): 2028900.0
EU funding (EUR): 1420230.0
Participants: 1
Project status: CLOSED

There is a need for cost-effective molecular point of care diagnostic tools to provide better healthcare to patients and better agility to our healthcare system. And what about going one step further by extending the limits of molecular diagnostics to the nano-scale? The market needs a rapid and definitive answer at entry level. Needs a diagnostic that is capable of screen directly and simply hundreds of samples with low infrastructure and low-grade people, that can rely on existing peripheral infrastructure like peripheral hospital and microscopy centres. We have developed the nano-technology-based solution NANO4. NANO4 is a fast and user-friendly nano-based diagnostic technology suitable for use at the Point of Need. NANO4 represents a highly specific and sensitive nanotechnology for in vitro molecular diagnostics. It uses gold nano-probes to recognize the complementary DNA/RNA strand and yield a colour output that allows for quick decision making. Molecular diagnosis is a multi-million Euro market and making use of our SME Instrument Phase 1 Feasibility Study, we defined our go-to-market roadmap for our first disruptive products: NANO4 TB for Tuberculosis, and NANO4 CML for Chronic Myeloid Leukaemia, including industrial scale-up and CE mark. We have already established partnerships with distributors in Europe and Brazil, and our technology has been referenced by FIND as a promising new solution for TB diagnosis. We have also established a connection with the World Health Organization, in order to obtain an endorsement as soon as we receive the CE mark. NANO4 was founded in end 2015, and we have raised €200.000 from Business Angels and have already begun our operations to take our products to the market, expecting a Series A at the end of 2018. With the successful conclusion of this project, NANO4 will become one of the few companies in Europe to possess nanotechnology capacities at industrial scale, focused on the life sciences sector.

Keywords: nanotechnology,nano materials,nano engineering,nano processes nano materials production and properties,pon diagnostics,molecular diagnostics,nano based diagnostics,cancer
Fundamental Building Blocks – Understanding plasticity in complex crystals based on their simplest, intergrown units (FunBlocks)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-06-01
End date: 2025-11-30
Duration (months): 66.0
Total project cost (EUR): 1499719.0
EU funding (EUR): 1499719.0
Participants: 1
Project status: SIGNED

New structural materials with higher strength and temperature capabilities are the key enablers of sustain-able energy conversion and transport technology of the future. The question is: How do we find those central high-performers combining high strength and the essential deformability giving safety in application? It is the aim of FUNBLOCKS to provide the first systematic studies of plasticity mechanisms in the most fundamental building blocks of complex crystals. These will allow us to deduce the missing basic mechanisms and signatures of plasticity. FUNBLOCKS will take a new approach by studying the much simpler sub-units that form the multitude of more complex crystals with large unit cells amongst the intermetallics. This has three major implications: i) the reduction to fundamental units allows suffi-cient time to unravel the major deformation mechanisms to the atomic level, ii) the recurrent nature of the few fundamental building blocks will allow a transfer of this knowledge to a large number of complex phases and iii) together, this will enable data mining from the vast and largely unexplored phase space of intermetallics. The key aspect of FUNBLOCKS is therefore to close the existing gap in knowledge and allow us to find promising new phases by elucidating the fundamental relationships between crystal structure and plasticity beyond what we know in simple metals. To identify and quantify the intrinsic mechanical properties of each sub-unit, state-of-the-art micromechanical testing techniques will be used. Transfer of data and verification of the central hypothesis, that fundamental units govern plasticity in complex crystals, will be achieved via additional alloyed crystals forming ternary variants of the binary structures. Ultimately, FUNBLOCKS will answer fundamental questions in plasticity, most prominently the interplay of deformation and structure in complex crystals, and thereby support the development of new high performance materials.

Keywords: plastic deformation of materials,electron microscopy,mechanical properties
Nature Based Solutions for re-naturing cities: knowledge diffusion and decision support platform through new collaborative models (Nature4Cities)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Spain,Spain,Spain,Austria,Italy,Türkiye,Hungary,Hungary,France,France,France,France,France,France,France,Netherlands,United Kingdom,Luxembourg
Call: New governance, business, financing models and economic impact assessment tools for sustainable cities with nature-based solutions (urban re-naturing) (H2020-SCC-NBS-1stage-2016, 2016)
Start date: 2016-11-01
End date: 2021-04-30
Duration (months): 54.0
Total project cost (EUR): 7499981.25
EU funding (EUR): 7499981.25
Participants: 31
Project status: CLOSED

Based on a detailed mapping of urban challenges and relevant nature-based solutions (NBS), Nature4Cities aims at developing complementary and interactive modules to engage urban stakeholders in a collective-learning process about re-naturing cities, develop and circulate new business, financial and governance models for NBS projects, as well as provide tools for the impacts assessment, valorisation and follow-up of NBS projects. The different modules are: • a database of generic NBS and associated environmental, economic and social performances • an observatory of NBS projects best practices / case studies • a set of innovative business, financial and governance models for the deployment of NBS in a range of different contexts, together with a tool to help urban stakeholders identify eligible models regarding their NBS project contexts • a NBS project impact assessment toolbox providing capabilities for environmental, economic and social impacts evaluation at different stages in the project development cycle from opportunity/feasibility studies to design steps and project follow-up). This toolbox will built on a range of tools, from generic indicator-based assessment for early project stages, down to detailed modelisations of NBS behaviors. These modules that already have a proper purpose on their own, will furthermore be integrated in a NBS dissemination and assessment self-learning platform [N4C Platform] to assist NBS project developers along the entire life cycle of their projects from opportunity studies and project definition down to performance monitoring. Nature4Cities indicators, methodologies, tools and platform will be field tested in real working environments and on real nature-based solution projects and developments in selected cities in Europe, which will be partners of the project and engage their technical urban and environmental planning teams.

Keywords: nature based solutions,re naturing cities,urban metabolism,participatory engagement,holistic assessment tools,extensive knowledge base
Ice Chilling System for Enhanced Food Cooling (ICECHILLING)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Iceland
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The IceChilling project will demonstrate an enhanced cooling system as an add-on solution for the air chilling and spray chilling methods current used by most poultry meat processors. Food safety and quality are the main concerns of consumers who demand more fresh foods, longer shelf-life and safer foods. Western consumers eat 30-50 kg of chicken meat per person/year and they prefer fresh meat over frozen. As up to 75% of chickens are contaminated with Camphylobacter, this is a major concern and challenge for the meat industry and health authorities. Increased size of chickens, along with high speed slaughterhouse output requires more efficient cooling than is possible with the currently used technology alone. The ThorIce add-on solution provides increased chilling efficiency that is applicable in most current facilities, without the need to build larger chilling chambers or installing of longer conveyer belts. Therefore, offering great savings for the meat processor, as well as improved food quality and safety. The ThorIce group is a specialized manufacturer of high-quality ice-slurry generators with >300 units sold worldwide since 2006. ThorIce has now developed the new IceGun system (patent pending) composed of ice-slurry generator, circulation system and the IceGun unit that delivers dewatered soft ice onto a target, such as a chicken carcass on a conveyer belt. The primary customers are poultry slaughterhouses but also other meat and fish processing industries. The first ThorIce system has already been developed and demonstrated effectively at Matfugl chicken meat processor in Iceland and the next one is being developed for a Hungarian customer. The 1st phase feasibility assessment is intended to result in a comprehensive business plan for demonstration and marketing of the IceChilling solution on a European/Global scale as a fully integrated, multi-component technology, remotely monitored and controlled via the internet.

Keywords: food processing,robotics and automatic control,energy efficiency,food waste,slurry ice,chilling,cooling,poultry,meat processing,shelf life,poultry slaughterhouses,food quality and safety