Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
6thSense Asset Valorisation Action (6SAVA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Serbia,Spain,Bosnia and Herzegovina,Croatia
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-02-01
End date: 2026-07-31
Duration (months): 30.0
Total project cost (EUR): 1198040.0
EU funding (EUR): 1198040.0
Participants: 5
Project status: SIGNED

6SAVA, or "6thSense Asset Valorisation Action", is a strategic coordination support action aimed at propelling the mature outcomes of the H2020 project SIXTHSENSE to a wider market. SIXTHSENSE developed an innovative system for monitoring vital parameters of first responders in extreme environments, reaching TRL5. 6SAVA focuses on a streamlined version of SIXTHSENSE to drive the commercialization of mature assets in Republic of Serbia (RS), Croatia (HR), and Bosnia and Herzegovi, leveraging national and regional funding. This initiative empowers core SIXTHSENSE partners to capitalize on their results in the regional context. The project harnesses two distinct assets: 1) An Industry 4.0 Health Monitoring Device ensures employee safety in physically demanding manufacturing jobs, starting from cement, petrochemical, and paper industries. 2) Comprehensive IT Solution for Firefighter Operational Management, with potential for generalisation and application across the civil protection sector. The primary objective of 6SAVA is to align technology specifications with the national smart specialization strategies (S3) and needs of local industrial actors. It will result in crafting high-quality applications for national/regional funding to support advancing these technologies toward market readiness, and enhancing technology uptake within the targeted regions. This will be achieved through workshops to engage stakeholders from the industry, national institutions responsible for cohesion policy and funding, and technology innovation drivers (universities and RTO). Additionally 6SAVA will drive knowledge transfer and technological adoption in HR, RS and BA through targeted activities developed by TECNALIA, a leading European innovation center. 6SAVA's ultimate goal is to amplify the impact of SIXTHSENSE innovations, creating a positive ripple effect throughout the region's technological landscape.
Atypical Liquid Crystal Elastomers: from Materials Innovation to Scalable processing and Transformative applications (ALCEMIST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Luxembourg,United Kingdom,Portugal
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-03-01
End date: 2031-02-28
Duration (months): 72.0
Total project cost (EUR): 8477534.0
EU funding (EUR): 8477534.0
Participants: 3
Project status: SIGNED

ALCEMIST challenges the conventional engineering mindset where passive static components (beams, wires, joints) are driven by active dynamic ones (motors, dampers, sensors); our innovative materials enable the combined functionality in a single component. This bold ambition is feasible because our research will unlock the full potential of liquid crystal elastomers (LCEs), unique responsive materials that reversibly change shape, colour, adhesive or damping properties, triggered by stimuli like heat, light, humidity or strain. We propose a radically new sustainable materials platform based on polysaccharides, functionalising precursors such that anyone-using click chemistry-can make LCEs that are powerful yet biocompatible and biodegradable, at one tenth of the cost of state-of-the-art LCEs. Further, using bond-exchange chemistry, ALCEMIST LCEs will be re-processable and re-usable. We also present a ground-breaking processing approach based on flow patterning to make large-scale LCEs of complex shapes and actuation modes. The synergy of three perfectly complementary and highly productive scientists, each a recognised leader in their field, enables this transformative approach to making atypical LCEs. As all our methods are ideal for industrial upscaling, we will also demonstrate the yet untapped potential of LCEs when they are applied in atypical contexts, totally different from the current mainstream academic focus. These range from adhesives that can be reversibly debonded on demand or sun-powered adaptive building elements which save energy and improve indoor atmosphere, to microhearts and peristaltic vasculature that can remove the growth limits of lab-grown organs, or smart threads that give doctors critical feedback on suture tension when conducting robotic surgery. By overthrowing multiple conventions in the ways LCEs are synthesised, studied and engineered, ALCEMIST will enable and stimulate new lines of research, basic and applied, across large communities.

Keywords: liquid crystals,liquid crystal elastomers,cellulose chemistry and physics
Targeted Protein Degradation as a New Experimental and Therapeutic Approach for Pancreatic Ductal Adenocarcinoma (PROTAC-PDAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1999401.0
EU funding (EUR): 1999401.0
Participants: 2
Project status: SIGNED

Pancreatic ductal adenocarcinoma (PDAC) is a life-threatening disease with few treatment options. Recently, the chemical space for targeted therapeutics was significantly increased by the development of compounds that induce protein degradation (PROTACs), but so far, they are unavailable for PDAC. The main motivation of PROTAC-PDAC is to develop novel targeted therapies for PDAC. The project is based on our accomplishments in three crucial areas. First, my group identified – as target candidates – a series of transcription factors that are absolutely required for PDAC growth in vivo. Second, we developed dozens of potent, specific PROTACs, thereby gaining deep insight into the underlying design principles and synthesis procedures. Third, we established genetic models in mice for simulating PROTAC function and discovering ideal target–E3 ligase pairs. In PROTAC-PDAC, we will develop compounds that degrade key oncogenic transcription factors and inhibit pancreatic tumor growth with minimal toxicity in healthy tissues. We will start by implementing the Auxin degron system in a murine PDAC model, to induce degradation of the target candidates and select four priority targets with the highest therapeutic index (Aim I). Then, we will assess their oncogenic functions by analyzing molecular, cellular and organismic consequences of acute depletion in mice (Aim II). In parallel, we will develop pharmaceutical PROTACs to induce target degradation and analyze their efficacy in PDAC models (Aim III). Finally, with the aim of developing less toxic PDAC therapy, we will identify pancreatic E3 ligases for the design of the first tissue-specific PROTACs that induce target degradation primarily in pancreatic tumor cells (Aim IV). While the main goal of PROTAC-PDAC is to develop new PROTAC-based therapeutic strategies, we will also establish groundbreaking methods and models leading to fundamental discoveries in PDAC biology.

Keywords: pancreatic ductal adenocarcinoma pdac,protacs,targeted protein degradation,non conventional cancer targets,auxin degron system aid,targeted therapy,pdac mouse models,tissue specific e3 ubiquitin ligases
Robotic bioreactors for the longitudinal control of restorative remodelling in the human skeletal muscle (ROBOREACTOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Muscle damage impairs vital functions e.g., movement, respiration. Recovery depends on the long-term interaction between neuromuscular and immune systems. If exposed to regimens of electro-mechanical stimuli, damaged muscles can remodel new structural properties over days. Inflammation at the damage site is initially needed to clear debris but if prolonged, as in many neuromuscular disorders, it may hamper structural remodeling. Rehabilitation robots such as exoskeletons and neurostimulators can deliver tunable stimuli to muscles. However, although they can compensate for lack of e.g., muscle strength (within seconds), they cannot control for how muscles remodel across days. ROBOREACTOR shifts the paradigm, to control muscle key inflammation and remodeling factors over large time scales, where the knowledge gap is. 1) I will develop robots that deliver electro-mechanical stimuli to fibres and innervating spinal neurons in humans across weeks. By combining biosignal processing and modeling, I will predict how robot-stimuli influence key inflammation and remodeling processes in vivo, with cell-scale resolution. 2) I will engineer human tissues in vitro and develop robots that can expose tissues to the same stimuli experienced by muscles during robotic training in vivo. This will enable modeling subcellular inflammation and remodeling factors, with detail not attained in humans. 3) I will fit subcellular models in vitro and embed them in multi-scale models built in vivo. This will create new model-based controllers to demonstrate how robots optimize for inflammation to enhance, otherwise hampered remodeling. With a focus on neural and muscular dependences in post-stroke subjects, I propose muscle remodeling as a proxy for neuromuscular repair, a new concept in neurorobotics. This opens to chronic robotic bioreactors, for maintenance of skeletal, cardiac, tubular organs; revisiting fundamental principles of human-robot interaction with broad impact on health.

Keywords: biorobotics emg driven musculoskeletal modelling exoskeletons movement neuromechanics muscle actuated simulation neurorehabilitation technologies rehabilitation robotics tissue engineering
Multidimensional generAtion of bulk Photovoltaic currents by vectorial Light Engineering (MAPLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Replacement of fossil fuels with renewable energy sources is one of the main challenges of our time. Harvesting solar radiation is a possible solution, as the sunlight power reaching Earth is orders of magnitude larger than human consumption. However, the efficiency of photovoltaic solar cells is limited by dissipation of all the photons energy exceeding the semiconductor bandgap according to the Shockley-Queisser (SQ) limit. The bulk photovoltaic (BPV) effect arising in non-centrosymmetric crystals has attracted considerable attention as above-bandgap electrons are predicted to contribute to the photocurrent, thus breaking the SQ limit. To enhance BPV-device efficiencies the underlying tensorial light-matter interaction needs further attention. Until now, the contribution from the three-dimensional shape of the electromagnetic field has been neglected, while a greater emphasis has been placed on the effect of the in-plane field gradient. A comprehensive theoretical and experimental understanding of the vectorial coupling between the conductivity tensor and the three-dimensional field structure is thus far lacking. The goal of this proposal is to identify the mechanism governing this coupling through carefully engineered light beams and by nanoscale mapping of the photocurrent with a novel scanning probe technique. This knowledge will be used to develop an optimization algorithm to improve BPV-devices efficiency: given a target material it will return the light structuring which maximizes the photocurrent generation. During the project I will complement my skills in scanning probe techniques, optics and solid-state physics with methods in structured light and materials science/engineering. This unique set of skills will enable the progress of my career in the emerging field of structured light-matter interactions. At the same time, I will acquire the necessary transferrable skills (leadership, communication and grant writing) to become an independent group leader.

Keywords: scanning probe techniques,structured light,numerical optimization
Development of hybrid tip-enhanced IR-Raman microscopy for the study of molecular optomechanical upconversion (TERRaMoOn)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-01-31
Duration (months): 29.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Optical control of mechanical oscillators of widely different dimensions are all described by the same cavity optomechanics interaction between phonons and photons inside a cavity. In the previous decades, various research groups leveraged on this interaction to cool the mechanical oscillators to its ground-state and to produce and detect quantum states of light.The applicant wants to take advantage of mechanical modes that are deeply in their ground state at room temperature, namely vibrational modes of molecules with resonance frequencies in the IR to THz frequency range (between 1-100 THz) to explore the novel molecular optomechanical frequency conversion process (m-OMC). The key idea of the process consists in upconverting a weak IR signal into the visible domain via molecules (with modes both Raman and IR active) placed onto metallic nanoantennas, opening the whole toolbox of visible field manipulation and detection to electromagnetic fields in the IR range. The goal of TERRaMoOn is to study the m-OMC process with a hybrid near-field microscope, where the near-field probe (metallic atomic force microscopy (AFM) tip) takes over the role of one of the antennas. In the near-field microscopy approach, the tip-antenna configuration can be tuned in-situ offering unprecedented versatility to the m-OMC process and enabling to access fundamental insights that would be inaccessible to typically studied on-chip devices. m-OMC could also lead to a new modality of near-field microscopy, where IR modes could be imaged with nanoscale spatial resolution and with exceptional sensitivity by making use of the frequency conversion process. The molecular layers studied during the project will finally enable the first unambiguous measurements of vibrational strong coupling via a Raman experiment. As such, TERRaMoOn promises to open novel enticing fundamental and technological research directions and to have a long-standing impact in the field.

Keywords: near field optical microscopy molecular optomechanics frequency upconversion
Systolic and diastolic estimates in geometry (Systoles-diastoles)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Luxembourg,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

The project is devoted to two classes of metric invariants of Riemannian and contact manifolds: systoles and diastoles. Riemannian systoles are shortest non-contractible curves (and higher-dimensional cycles) on manifolds and other spaces. Diastoles measure longest curves in an optimal slicing of a manifold into a family of curves (or cycles). Symplectic/contact systoles measure the least action on closed characteristics (integral curves of the Reeb flow). The goals of the project are to extend and complement the results of M. Gromov, M. Freedman, C. Viterbo, and others, by relating all these invariants to the volumes of the corresponding spaces and other metric quantities. A key tool for investigating the systolic freedom (measured as the behavior of several systoles compared to the volume) is its connections with quantum error correction codes, which are a promising rich source of spaces of great systolic freedom. The diastolic geometry, which is the study of waists of slicings/foliations/sweepouts via the methods of geometric analysis, has applications to the open Buser pants decomposition problem, as well as connections with persistence and dimensionality reduction in manifold learning. The symplectic isosystolic/isodiastolic conjecture of Viterbo, which will be studied via extensions of billiard approach, has exciting implications in convexity, namely the longstanding Mahler conjecture on the volume product. My experience in waist and width estimates, combined with the expertise of Prof. Hugo Parlier in systolic geometry and Buser's problem, will help me to carry out this project at the University of Luxembourg. The secondment at Freie Universität Berlin in the quantum group of Prof. Jens Eisert will help me to bring closer the systolic and quantum topics of research as well as the communities of researchers.

Keywords: systole,systolic freedom,diastole,waist,urysohn width,sweepout,metric geometry,isoperimetry,action of closed characteristics,systolic ratio,zoll manifold,billiards,quantum error correction
SERVICES FOR HYDROGEN INNOVATION FACILITATION AND TESTING (H2SHIFT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Innovation actions
Countries involved: Italy,Denmark,Spain,Iceland,Germany,France,United Kingdom
Call: Open Pilot Line/Test Bed for hydrogen (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 9102035.83
EU funding (EUR): 7211180.45
Participants: 16
Project status: SIGNED

H2SHIFT – Services for Hydrogen Innovation Facilitation and Testing aims to create the first Open Innovation Test Bed for innovative hydrogen production technologies open to startups and SMEs from Europe and globally. H2SHIFT will be a Single Entry Point offering open access to unrivalled resources, innovative infrastructures, unique expertise and capabilities, arranged in a challenging Acceleration Programme. The proposed innovation model combines: • Hydrogen production testing services, including 7 test lines grouped in 4 clusters (Advanced water electrolysis, Bio-hydrogen, Direct-solar Hydrogen production, Hydrogen production in offshore environment); • Technology upscaling services, such as Prototyping for industrial scalability, and Computational modelling; • Non-technical services, among Techno-economic and environmental assessment, Legal and regulation compliance, and Business development. The initiative boosts the Clean H2 JU SRIA on the path towards the upscaling of unmatched and competitive hydrogen production technologies distinctively trailblazing innovation in high-temperature and AEM electrolysis, bio-hydrogen, direct-solar and offshore H2 production, to build a complete portfolio with existing OITB projects dedicated to AEL and PEM technologies. H2SHIFT kickstarts a collaborative ecosystem throughout Europe that links research, academia, and industry, along with final investors, working closely with startups and SMEs to advance groundbreaking solutions that will be demonstrated in industrial environment to advance their technology readiness and market uptake. Remarkably, H2SHIIFT scales up an open pay-per-use hub intended to circumvent expensive costs for early-stage innovators, lowering investment risks for potential investors and contributing to attract private capital for innovation. It contributes to make hydrogen a key part of a cleaner and more secure energy future, and a catalyst for EU leadership in innovative hydrogen technologies.

Keywords: high temperature aem electrolysis bio h2,direct solar and offshore h2 production prototyping for industrial scalability computational modelling regulatory compliance,circularity by design